Accession_ID	Pathway_Count	Pathway_IDs	Pathway_Names
Medex_00069750-RA	3	Reactome: R-HSA-422085;Reactome: R-HSA-1483191;Reactome: R-HSA-112311	"Synthesis, secretion, and deacylation of Ghrelin";"Synthesis of PC";"Neurotransmitter clearance"
Medex_00027696-RA	2	Reactome: R-HSA-8876198;Reactome: R-HSA-5357905	"RAB GEFs exchange GTP for GDP on RABs";"Regulation of TNFR1 signaling"
Medex_00004910-RA	2	Reactome: R-HSA-1660662;Reactome: R-HSA-390471	"Glycosphingolipid metabolism";"Association of TriC/CCT with target proteins during biosynthesis"
Medex_00059954-RA	2	Reactome: R-HSA-6782315;MetaCyc: PWY-6829	"tRNA modification in the nucleus and cytosol";"Trna methylation (yeast)"
Medex_00030170-RA	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00029164-RA	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
Medex_00004638-RA	1	Reactome: R-HSA-2024096	"HS-GAG degradation"
Medex_00033157-RA	2	Reactome: R-HSA-72163;Reactome: R-HSA-72165	"mRNA Splicing - Major Pathway";"mRNA Splicing - Minor Pathway"
Medex_00050989-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Medex_00042806-RA	7	MetaCyc: PWY-7818;MetaCyc: PWY-3385;KEGG: 00564+2.7.1.32+2.7.1.82;Reactome: R-HSA-1483191;MetaCyc: PWY-7886;Reactome: R-HSA-1483213;MetaCyc: PWY-7782	"Type IV lipoteichoic acid biosynthesis (S. pneumoniae)";"Choline biosynthesis I";"Glycerophospholipid metabolism";"Synthesis of PC";"Cell-surface glycoconjugate-linked phosphocholine biosynthesis";"Synthesis of PE";"Plasmalogen biosynthesis"
Medex_00008252-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Medex_00023733-RA	1	Reactome: R-HSA-2022377	"Metabolism of Angiotensinogen to Angiotensins"
Medex_00093610-RA	16	Reactome: R-HSA-975956;Reactome: R-HSA-72706;Reactome: R-HSA-72764;Reactome: R-HSA-72702;Reactome: R-HSA-6791226;Reactome: R-HSA-975957;Reactome: R-HSA-1799339;Reactome: R-HSA-9633012;Reactome: R-HSA-72689;Reactome: R-HSA-2408557;Reactome: R-HSA-192823;Reactome: R-HSA-72649;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-156902;Reactome: R-HSA-72695	"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Eukaryotic Translation Termination";"Ribosomal scanning and start codon recognition";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Formation of a pool of free 40S subunits";"Selenocysteine synthesis";"Viral mRNA Translation";"Translation initiation complex formation";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Peptide chain elongation";"Formation of the ternary complex, and subsequently, the 43S complex"
Medex_00003991-RA	15	Reactome: R-HSA-4641262;Reactome: R-HSA-5358747;Reactome: R-HSA-5339716;Reactome: R-HSA-196299;Reactome: R-HSA-5689896;Reactome: R-HSA-5358752;Reactome: R-HSA-195253;Reactome: R-HSA-3769402;Reactome: R-HSA-111465;Reactome: R-HSA-5467337;Reactome: R-HSA-5467348;Reactome: R-HSA-5358751;Reactome: R-HSA-5358749;Reactome: R-HSA-5467333;Reactome: R-HSA-5467340	"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"S33 mutants of beta-catenin aren't phosphorylated";"Misspliced GSK3beta mutants stabilize beta-catenin";"Beta-catenin phosphorylation cascade";"Ovarian tumor domain proteases";"T41 mutants of beta-catenin aren't phosphorylated";"Degradation of beta-catenin by the destruction complex";"Deactivation of the beta-catenin transactivating complex";"Apoptotic cleavage of cellular proteins";"APC truncation mutants have impaired AXIN binding";"Truncations of AMER1 destabilize the destruction complex";"S45 mutants of beta-catenin aren't phosphorylated";"S37 mutants of beta-catenin aren't phosphorylated";"APC truncation mutants are not K63 polyubiquitinated";"AXIN missense mutants destabilize the destruction complex"
Medex_00053756-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00042230-RA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00028585-RA	11	KEGG: 00230+4.6.1.1;Reactome: R-HSA-170660;Reactome: R-HSA-5610787;Reactome: R-HSA-418597;Reactome: R-HSA-432040;Reactome: R-HSA-418594;Reactome: R-HSA-163615;Reactome: R-HSA-418555;Reactome: R-HSA-164378;Reactome: R-HSA-163359;Reactome: R-HSA-170670	"Purine metabolism";"Adenylate cyclase activating pathway";"Hedgehog 'off' state";"G alpha (z) signalling events";"Vasopressin regulates renal water homeostasis via Aquaporins";"G alpha (i) signalling events";"PKA activation";"G alpha (s) signalling events";"PKA activation in glucagon signalling";"Glucagon signaling in metabolic regulation";"Adenylate cyclase inhibitory pathway"
Medex_00068272-RA	1	Reactome: R-HSA-428890	"Role of ABL in ROBO-SLIT signaling"
Medex_00074398-RA	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
Medex_00031594-RA	2	Reactome: R-HSA-6782315;Reactome: R-HSA-6787450	"tRNA modification in the nucleus and cytosol";"tRNA modification in the mitochondrion"
Medex_00047034-RA	1	Reactome: R-HSA-5620922	"BBSome-mediated cargo-targeting to cilium"
Medex_00064318-RA	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
Medex_00050855-RA	8	KEGG: 00270+1.1.1.27;KEGG: 00620+1.1.1.27;KEGG: 00640+1.1.1.27;KEGG: 00010+1.1.1.27;MetaCyc: PWY-5481;Reactome: R-HSA-70268;MetaCyc: PWY-8086;MetaCyc: PWY-6901	"Cysteine and methionine metabolism";"Pyruvate metabolism";"Propanoate metabolism";"Glycolysis / Gluconeogenesis";"Pyruvate fermentation to (S)-lactate";"Pyruvate metabolism";"(S)-lactate fermentation to propanoate, acetate and hydrogen";"Superpathway of glucose and xylose degradation"
Medex_00016156-RA	2	Reactome: R-HSA-383280;Reactome: R-HSA-4090294	"Nuclear Receptor transcription pathway";"SUMOylation of intracellular receptors"
Medex_00089210-RA	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
Medex_00002748-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Medex_00073164-RA	1	Reactome: R-HSA-196783	"Coenzyme A biosynthesis"
Medex_00015486-RA	14	Reactome: R-HSA-380284;Reactome: R-HSA-2467813;Reactome: R-HSA-68877;Reactome: R-HSA-8852276;Reactome: R-HSA-380270;Reactome: R-HSA-9648025;Reactome: R-HSA-380259;Reactome: R-HSA-5663220;Reactome: R-HSA-5620912;Reactome: R-HSA-2500257;Reactome: R-HSA-8854518;Reactome: R-HSA-141444;Reactome: R-HSA-380320;Reactome: R-HSA-2565942	"Loss of proteins required for interphase microtubule organization from the centrosome";"Separation of Sister Chromatids";"Mitotic Prometaphase";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Recruitment of mitotic centrosome proteins and complexes";"EML4 and NUDC in mitotic spindle formation";"Loss of Nlp from mitotic centrosomes";"RHO GTPases Activate Formins";"Anchoring of the basal body to the plasma membrane";"Resolution of Sister Chromatid Cohesion";"AURKA Activation by TPX2";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Recruitment of NuMA to mitotic centrosomes";"Regulation of PLK1 Activity at G2/M Transition"
Medex_00034983-RA	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
Medex_00033854-RA	3	Reactome: R-HSA-379726;Reactome: R-HSA-379716;KEGG: 00970+6.1.1.14	"Mitochondrial tRNA aminoacylation";"Cytosolic tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis"
Medex_00048979-RA	1	Reactome: R-HSA-2559584	"Formation of Senescence-Associated Heterochromatin Foci (SAHF)"
Medex_00022994-RA	2	Reactome: R-HSA-400253;Reactome: R-HSA-2151201	"Circadian Clock";"Transcriptional activation of mitochondrial biogenesis"
Medex_00034647-RA	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00051414-RA	1	Reactome: R-HSA-211981	"Xenobiotics"
Medex_00031398-RA	1	KEGG: 00760+2.3.1.286	"Nicotinate and nicotinamide metabolism"
Medex_00071580-RA	3	Reactome: R-HSA-6798695;MetaCyc: PWY-6807;KEGG: 00511+3.2.1.51	"Neutrophil degranulation";"Xyloglucan degradation II (exoglucanase)";"Other glycan degradation"
Medex_00037772-RA	24	Reactome: R-HSA-3371497;Reactome: R-HSA-2500257;Reactome: R-HSA-380320;Reactome: R-HSA-1445148;Reactome: R-HSA-5663220;Reactome: R-HSA-68877;Reactome: R-HSA-9648025;Reactome: R-HSA-6811434;Reactome: R-HSA-5617833;Reactome: R-HSA-9646399;Reactome: R-HSA-2467813;Reactome: R-HSA-2132295;Reactome: R-HSA-5626467;Reactome: R-HSA-6811436;Reactome: R-HSA-9609690;Reactome: R-HSA-8955332;Reactome: R-HSA-437239;Reactome: R-HSA-6807878;Reactome: R-HSA-9619483;Reactome: R-HSA-190861;Reactome: R-HSA-190840;Reactome: R-HSA-8852276;Reactome: R-HSA-9609736;Reactome: R-HSA-983189	"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Resolution of Sister Chromatid Cohesion";"Recruitment of NuMA to mitotic centrosomes";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"RHO GTPases Activate Formins";"Mitotic Prometaphase";"EML4 and NUDC in mitotic spindle formation";"COPI-dependent Golgi-to-ER retrograde traffic";"Cilium Assembly";"Aggrephagy";"Separation of Sister Chromatids";"MHC class II antigen presentation";"RHO GTPases activate IQGAPs";"COPI-independent Golgi-to-ER retrograde traffic";"HCMV Early Events";"Carboxyterminal post-translational modifications of tubulin";"Recycling pathway of L1";"COPI-mediated anterograde transport";"Activation of AMPK downstream of NMDARs";"Gap junction assembly";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Assembly and cell surface presentation of NMDA receptors";"Kinesins"
Medex_00072272-RA	1	Reactome: R-HSA-6794361	"Neurexins and neuroligins"
Medex_00061658-RA	8	KEGG: 00500+2.7.1.1;KEGG: 00052+2.7.1.1;KEGG: 00521+2.7.1.1;Reactome: R-HSA-70171;KEGG: 00520+2.7.1.1;KEGG: 00051+2.7.1.1;KEGG: 00010+2.7.1.1;KEGG: 00524+2.7.1.1	"Starch and sucrose metabolism";"Galactose metabolism";"Streptomycin biosynthesis";"Glycolysis";"Amino sugar and nucleotide sugar metabolism";"Fructose and mannose metabolism";"Glycolysis / Gluconeogenesis";"Neomycin, kanamycin and gentamicin biosynthesis"
Medex_00016151-RA	1	Reactome: R-HSA-8951664	"Neddylation"
Medex_00037868-RA	4	KEGG: 00520+3.2.1.14;MetaCyc: PWY-6855;MetaCyc: PWY-7822;MetaCyc: PWY-6902	"Amino sugar and nucleotide sugar metabolism";"Chitin degradation I (archaea)";"Chitin degradation III (Serratia)";"Chitin degradation II (Vibrio)"
Medex_00091843-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Medex_00091631-RA	3	Reactome: R-HSA-8963684;KEGG: 00350+3.7.1.2;KEGG: 00643+3.7.1.2	"Tyrosine catabolism";"Tyrosine metabolism";"Styrene degradation"
Medex_00015391-RA	9	Reactome: R-HSA-114608;Reactome: R-HSA-6802946;Reactome: R-HSA-9649948;Reactome: R-HSA-5674135;Reactome: R-HSA-6802948;Reactome: R-HSA-6798695;Reactome: R-HSA-445355;Reactome: R-HSA-6802955;Reactome: R-HSA-6802952	"Platelet degranulation";"Signaling by moderate kinase activity BRAF mutants";"Signaling downstream of RAS mutants";"MAP2K and MAPK activation";"Signaling by high-kinase activity BRAF mutants";"Neutrophil degranulation";"Smooth Muscle Contraction";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"Signaling by BRAF and RAF fusions"
Medex_00022044-RA	1	Reactome: R-HSA-73621	"Pyrimidine catabolism"
Medex_00024704-RA	13	Reactome: R-HSA-1799339;Reactome: R-HSA-9633012;Reactome: R-HSA-156902;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-975957;Reactome: R-HSA-192823;Reactome: R-HSA-2408557;Reactome: R-HSA-6791226;Reactome: R-HSA-72706;Reactome: R-HSA-975956;Reactome: R-HSA-72764;Reactome: R-HSA-72689	"SRP-dependent cotranslational protein targeting to membrane";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Viral mRNA Translation";"Selenocysteine synthesis";"Major pathway of rRNA processing in the nucleolus and cytosol";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Formation of a pool of free 40S subunits"
Medex_00093626-RA	4	KEGG: 00310+1.2.4.2;MetaCyc: PWY-5084;KEGG: 00380+1.2.4.2;KEGG: 00020+1.2.4.2	"Lysine degradation";"2-oxoglutarate decarboxylation to succinyl-CoA";"Tryptophan metabolism";"Citrate cycle (TCA cycle)"
Medex_00013189-RA	2	Reactome: R-HSA-196783;KEGG: 00770+6.3.2.5	"Coenzyme A biosynthesis";"Pantothenate and CoA biosynthesis"
Medex_00075363-RA	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
Medex_00014171-RA	13	KEGG: 00640+6.2.1.5;MetaCyc: PWY-5392;KEGG: 00720+6.2.1.5;KEGG: 00020+6.2.1.5;MetaCyc: PWY-5538;Reactome: R-HSA-71403;MetaCyc: PWY-6969;MetaCyc: PWY-5913;MetaCyc: PWY-5537;MetaCyc: PWY-6728;MetaCyc: PWY-7384;MetaCyc: PWY-5690;KEGG: 00660+6.2.1.5	"Propanoate metabolism";"Reductive TCA cycle II";"Carbon fixation pathways in prokaryotes";"Citrate cycle (TCA cycle)";"Pyruvate fermentation to acetate VI";"Citric acid cycle (TCA cycle)";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Partial TCA cycle (obligate autotrophs)";"Pyruvate fermentation to acetate V";"Methylaspartate cycle";"Anaerobic energy metabolism (invertebrates, mitochondrial)";"TCA cycle II (plants and fungi)";"C5-Branched dibasic acid metabolism"
Medex_00025496-RA	1	Reactome: R-HSA-500753	"Pyrimidine biosynthesis"
Medex_00081307-RA	6	MetaCyc: PWY-6527;Reactome: R-HSA-5609978;MetaCyc: PWY-6317;KEGG: 00052+2.7.7.12;Reactome: R-HSA-70370;KEGG: 00520+2.7.7.12	"Stachyose degradation";"Defective GALT can cause Galactosemia";"D-galactose degradation I (Leloir pathway)";"Galactose metabolism";"Galactose catabolism";"Amino sugar and nucleotide sugar metabolism"
Medex_00102896-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00067886-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Medex_00022408-RA	4	Reactome: R-HSA-5205685;Reactome: R-HSA-1632852;Reactome: R-HSA-8934903;Reactome: R-HSA-936440	"Pink/Parkin Mediated Mitophagy";"Macroautophagy";"Receptor Mediated Mitophagy";"Negative regulators of DDX58/IFIH1 signaling"
Medex_00019489-RA	3	KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16	"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway"
Medex_00055441-RA	5	Reactome: R-HSA-70171;MetaCyc: PWY-5514;MetaCyc: PWY-6855;KEGG: 00520+3.5.99.6;MetaCyc: PWY-6906	"Glycolysis";"UDP-N-acetyl-D-galactosamine biosynthesis II";"Chitin degradation I (archaea)";"Amino sugar and nucleotide sugar metabolism";"Chitin derivatives degradation"
Medex_00069940-RA	6	MetaCyc: PWY-6118;Reactome: R-HSA-1483166;Reactome: R-HSA-163560;MetaCyc: PWY-6952;KEGG: 00564+1.1.5.3;MetaCyc: PWY-4261	"Glycerol-3-phosphate shuttle";"Synthesis of PA";"Triglyceride catabolism";"Glycerophosphodiester degradation";"Glycerophospholipid metabolism";"Glycerol degradation I"
Medex_00077242-RA	7	Reactome: R-HSA-445095;Reactome: R-HSA-6798695;Reactome: R-HSA-6807878;Reactome: R-HSA-373753;Reactome: R-HSA-375165;Reactome: R-HSA-5673001;Reactome: R-HSA-264870	"Interaction between L1 and Ankyrins";"Neutrophil degranulation";"COPI-mediated anterograde transport";"Nephrin family interactions";"NCAM signaling for neurite out-growth";"RAF/MAP kinase cascade";"Caspase-mediated cleavage of cytoskeletal proteins"
Medex_00073389-RA	2	Reactome: R-HSA-70263;Reactome: R-HSA-70171	"Gluconeogenesis";"Glycolysis"
Medex_00049324-RA	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
Medex_00035396-RA	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
Medex_00036324-RA	7	KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1	"Human cytomegalovirus infection";"Thermogenesis";"Relaxin signaling pathway";"Human papillomavirus infection";"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection"
Medex_00090385-RA	9	Reactome: R-HSA-110314;Reactome: R-HSA-6782135;Reactome: R-HSA-5696400;Reactome: R-HSA-8951664;Reactome: R-HSA-6781827;Reactome: R-HSA-5696395;Reactome: R-HSA-6781823;Reactome: R-HSA-6782210;Reactome: R-HSA-5696394	"Recognition of DNA damage by PCNA-containing replication complex";"Dual incision in TC-NER";"Dual Incision in GG-NER";"Neddylation";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Formation of Incision Complex in GG-NER";"Formation of TC-NER Pre-Incision Complex";"Gap-filling DNA repair synthesis and ligation in TC-NER";"DNA Damage Recognition in GG-NER"
Medex_00014176-RA	13	MetaCyc: PWY-6728;MetaCyc: PWY-5537;MetaCyc: PWY-5913;MetaCyc: PWY-6969;MetaCyc: PWY-7384;KEGG: 00660+6.2.1.5;MetaCyc: PWY-5690;MetaCyc: PWY-5392;KEGG: 00640+6.2.1.5;KEGG: 00720+6.2.1.5;KEGG: 00020+6.2.1.5;MetaCyc: PWY-5538;Reactome: R-HSA-71403	"Methylaspartate cycle";"Pyruvate fermentation to acetate V";"Partial TCA cycle (obligate autotrophs)";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Anaerobic energy metabolism (invertebrates, mitochondrial)";"C5-Branched dibasic acid metabolism";"TCA cycle II (plants and fungi)";"Reductive TCA cycle II";"Propanoate metabolism";"Carbon fixation pathways in prokaryotes";"Citrate cycle (TCA cycle)";"Pyruvate fermentation to acetate VI";"Citric acid cycle (TCA cycle)"
Medex_00049525-RA	10	MetaCyc: PWY-6842;MetaCyc: PWY-7112;MetaCyc: PWY-7559;MetaCyc: PWY-8001;MetaCyc: PWY-4061;MetaCyc: PWY-5826;KEGG: 00460+2.3.2.2;MetaCyc: PWY-4041;KEGG: 00430+2.3.2.2;KEGG: 00480+2.3.2.2+3.4.19.13	"Glutathione-mediated detoxification II";"4-hydroxy-2-nonenal detoxification";"Glutathione degradation (DUG pathway";"Felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis";"Glutathione-mediated detoxification I";"Hypoglycin biosynthesis";"Cyanoamino acid metabolism";"Gamma-glutamyl cycle";"Taurine and hypotaurine metabolism";"Glutathione metabolism"
Medex_00071510-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Medex_00045818-RA	3	Reactome: R-HSA-201722;Reactome: R-HSA-3214847;Reactome: R-HSA-5689880	"Formation of the beta-catenin:TCF transactivating complex";"HATs acetylate histones";"Ub-specific processing proteases"
Medex_00052449-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Medex_00073289-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00022641-RA	8	Reactome: R-HSA-68827;Reactome: R-HSA-176187;Reactome: R-HSA-68689;Reactome: R-HSA-68962;Reactome: R-HSA-113507;Reactome: R-HSA-68867;Reactome: R-HSA-68949;Reactome: R-HSA-68616	"CDT1 association with the CDC6:ORC:origin complex";"Activation of ATR in response to replication stress";"CDC6 association with the ORC:origin complex";"Activation of the pre-replicative complex";"E2F-enabled inhibition of pre-replication complex formation";"Assembly of the pre-replicative complex";"Orc1 removal from chromatin";"Assembly of the ORC complex at the origin of replication"
Medex_00091289-RA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00096605-RA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
Medex_00011745-RA	2	Reactome: R-HSA-6804115;Reactome: R-HSA-429947	"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Deadenylation of mRNA"
Medex_00080116-RA	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
Medex_00053679-RA	1	Reactome: R-HSA-6798163	"Choline catabolism"
Medex_00080058-RA	5	Reactome: R-HSA-3769402;Reactome: R-HSA-201722;Reactome: R-HSA-3214841;Reactome: R-HSA-8936459;Reactome: R-HSA-5617472	"Deactivation of the beta-catenin transactivating complex";"Formation of the beta-catenin:TCF transactivating complex";"PKMTs methylate histone lysines";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Activation of anterior HOX genes in hindbrain development during early embryogenesis"
Medex_00090530-RA	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
Medex_00090563-RA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
Medex_00021307-RA	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00103438-RA	1	Reactome: R-HSA-8949613	"Cristae formation"
Medex_00019818-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Medex_00093869-RA	5	Reactome: R-HSA-416482;Reactome: R-HSA-442982;Reactome: R-HSA-5673001;Reactome: R-HSA-194840;Reactome: R-HSA-193648	"G alpha (12/13) signalling events";"Ras activation upon Ca2+ influx through NMDA receptor";"RAF/MAP kinase cascade";"Rho GTPase cycle";"NRAGE signals death through JNK"
Medex_00050870-RA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
Medex_00019195-RA	3	Reactome: R-HSA-2408508;Reactome: R-HSA-1614603;Reactome: R-HSA-1614558	"Metabolism of ingested SeMet, Sec, MeSec into H2Se";"Cysteine formation from homocysteine";"Degradation of cysteine and homocysteine"
Medex_00016294-RA	6	Reactome: R-HSA-201722;Reactome: R-HSA-674695;Reactome: R-HSA-112382;Reactome: R-HSA-75955;Reactome: R-HSA-8866654;Reactome: R-HSA-5632684	"Formation of the beta-catenin:TCF transactivating complex";"RNA Polymerase II Pre-transcription Events";"Formation of RNA Pol II elongation complex";"RNA Polymerase II Transcription Elongation";"E3 ubiquitin ligases ubiquitinate target proteins";"Hedgehog 'on' state"
Medex_00076481-RA	2	Reactome: R-HSA-171319;Reactome: R-HSA-3214847	"Telomere Extension By Telomerase";"HATs acetylate histones"
Medex_00026907-RA	9	Reactome: R-HSA-5693568;Reactome: R-HSA-69473;Reactome: R-HSA-5693579;Reactome: R-HSA-6804756;Reactome: R-HSA-5693616;Reactome: R-HSA-5693554;Reactome: R-HSA-5685942;Reactome: R-HSA-5693607;Reactome: R-HSA-5685938	"Resolution of D-loop Structures through Holliday Junction Intermediates";"G2/M DNA damage checkpoint";"Homologous DNA Pairing and Strand Exchange";"Regulation of TP53 Activity through Phosphorylation";"Presynaptic phase of homologous DNA pairing and strand exchange";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"HDR through Homologous Recombination (HRR)";"Processing of DNA double-strand break ends";"HDR through Single Strand Annealing (SSA)"
Medex_00001762-RA	1	Reactome: R-HSA-69273	"Cyclin A/B1/B2 associated events during G2/M transition"
Medex_00062994-RA	5	Reactome: R-HSA-5693607;Reactome: R-HSA-69473;Reactome: R-HSA-5693565;Reactome: R-HSA-5693571;Reactome: R-HSA-5689901	"Processing of DNA double-strand break ends";"G2/M DNA damage checkpoint";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Nonhomologous End-Joining (NHEJ)";"Metalloprotease DUBs"
Medex_00100781-RA	2	KEGG: 04660+2.7.10.2;Reactome: R-HSA-428890	"T cell receptor signaling pathway";"Role of ABL in ROBO-SLIT signaling"
Medex_00014233-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00030305-RA	19	Reactome: R-HSA-8866423;Reactome: R-HSA-8856825;Reactome: R-HSA-8964026;Reactome: R-HSA-3000484;Reactome: R-HSA-5686938;Reactome: R-HSA-8964046;Reactome: R-HSA-8964038;Reactome: R-HSA-432142;Reactome: R-HSA-975634;Reactome: R-HSA-8957275;Reactome: R-HSA-202733;Reactome: R-HSA-3000497;Reactome: R-HSA-381426;Reactome: R-HSA-3000471;Reactome: R-HSA-8856828;Reactome: R-HSA-3000480;Reactome: R-HSA-8963901;Reactome: R-HSA-8963888;Reactome: R-HSA-8964041	"VLDL assembly";"Cargo recognition for clathrin-mediated endocytosis";"Chylomicron clearance";"Scavenging by Class F Receptors";"Regulation of TLR by endogenous ligand";"VLDL clearance";"LDL clearance";"Platelet sensitization by LDL";"Retinoid metabolism and transport";"Post-translational protein phosphorylation";"Cell surface interactions at the vascular wall";"Scavenging by Class H Receptors";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"Scavenging by Class B Receptors";"Clathrin-mediated endocytosis";"Scavenging by Class A Receptors";"Chylomicron remodeling";"Chylomicron assembly";"LDL remodeling"
Medex_00023121-RA	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
Medex_00027047-RA	2	Reactome: R-HSA-1660662;Reactome: R-HSA-390471	"Glycosphingolipid metabolism";"Association of TriC/CCT with target proteins during biosynthesis"
Medex_00079579-RA	1	Reactome: R-HSA-427359	"SIRT1 negatively regulates rRNA expression"
Medex_00005255-RA	1	Reactome: R-HSA-6811440	"Retrograde transport at the Trans-Golgi-Network"
Medex_00018790-RA	52	Reactome: R-HSA-69481;Reactome: R-HSA-5678895;Reactome: R-HSA-350562;Reactome: R-HSA-174113;Reactome: R-HSA-4641257;Reactome: R-HSA-1234176;Reactome: R-HSA-69017;Reactome: R-HSA-69601;Reactome: R-HSA-5362768;Reactome: R-HSA-5676590;Reactome: R-HSA-68827;Reactome: R-HSA-8948751;Reactome: R-HSA-1169091;Reactome: R-HSA-174154;Reactome: R-HSA-5607764;Reactome: R-HSA-174184;Reactome: R-HSA-8951664;Reactome: R-HSA-2871837;Reactome: R-HSA-5610783;Reactome: R-HSA-1236974;Reactome: R-HSA-8854050;Reactome: R-HSA-8939902;Reactome: R-HSA-75815;Reactome: R-HSA-195253;Reactome: R-HSA-5689880;Reactome: R-HSA-5610785;Reactome: R-HSA-5687128;Reactome: R-HSA-5668541;Reactome: R-HSA-5689603;Reactome: R-HSA-4608870;Reactome: R-HSA-5632684;Reactome: R-HSA-1236978;Reactome: R-HSA-349425;Reactome: R-HSA-180534;Reactome: R-HSA-5607761;Reactome: R-HSA-5610780;Reactome: R-HSA-8852276;Reactome: R-HSA-174178;Reactome: R-HSA-5658442;Reactome: R-HSA-5358346;Reactome: R-HSA-983168;Reactome: R-HSA-202424;Reactome: R-HSA-9020702;Reactome: R-HSA-4641258;Reactome: R-HSA-2467813;Reactome: R-HSA-180585;Reactome: R-HSA-450408;Reactome: R-HSA-9010553;Reactome: R-HSA-382556;Reactome: R-HSA-8939236;Reactome: R-HSA-68949;Reactome: R-HSA-211733	"G2/M Checkpoints";"Defective CFTR causes cystic fibrosis";"Regulation of ornithine decarboxylase (ODC)";"SCF-beta-TrCP mediated degradation of Emi1";"Degradation of AXIN";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"CDK-mediated phosphorylation and removal of Cdc6";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"NIK-->noncanonical NF-kB signaling";"CDT1 association with the CDC6:ORC:origin complex";"Regulation of PTEN stability and activity";"Activation of NF-kappaB in B cells";"APC/C:Cdc20 mediated degradation of Securin";"CLEC7A (Dectin-1) signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Neddylation";"FCERI mediated NF-kB activation";"Degradation of GLI2 by the proteasome";"ER-Phagosome pathway";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Regulation of RUNX2 expression and activity";"Ubiquitin-dependent degradation of Cyclin D";"Degradation of beta-catenin by the destruction complex";"Ub-specific processing proteases";"GLI3 is processed to GLI3R by the proteasome";"MAPK6/MAPK4 signaling";"TNFR2 non-canonical NF-kB pathway";"UCH proteinases";"Asymmetric localization of PCP proteins";"Hedgehog 'on' state";"Cross-presentation of soluble exogenous antigens (endosomes)";"Autodegradation of the E3 ubiquitin ligase COP1";"Vpu mediated degradation of CD4";"Dectin-1 mediated noncanonical NF-kB signaling";"Degradation of GLI1 by the proteasome";"The role of GTSE1 in G2/M progression after G2 checkpoint";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Regulation of RAS by GAPs";"Hedgehog ligand biogenesis";"Antigen processing: Ubiquitination & Proteasome degradation";"Downstream TCR signaling";"Interleukin-1 signaling";"Degradation of DVL";"Separation of Sister Chromatids";"Vif-mediated degradation of APOBEC3G";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Regulation of expression of SLITs and ROBOs";"ABC-family proteins mediated transport";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Orc1 removal from chromatin";"Regulation of activated PAK-2p34 by proteasome mediated degradation"
Medex_00032209-RA	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
Medex_00029207-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Medex_00065643-RA	26	Reactome: R-HSA-2500257;Reactome: R-HSA-380320;Reactome: R-HSA-3371497;Reactome: R-HSA-5663220;Reactome: R-HSA-1445148;Reactome: R-HSA-389960;Reactome: R-HSA-68877;Reactome: R-HSA-9648025;Reactome: R-HSA-6811434;Reactome: R-HSA-389977;Reactome: R-HSA-2467813;Reactome: R-HSA-5617833;Reactome: R-HSA-9646399;Reactome: R-HSA-5626467;Reactome: R-HSA-2132295;Reactome: R-HSA-190861;Reactome: R-HSA-190840;Reactome: R-HSA-6807878;Reactome: R-HSA-9619483;Reactome: R-HSA-437239;Reactome: R-HSA-9609690;Reactome: R-HSA-6811436;Reactome: R-HSA-8955332;Reactome: R-HSA-8852276;Reactome: R-HSA-983189;Reactome: R-HSA-9609736	"Resolution of Sister Chromatid Cohesion";"Recruitment of NuMA to mitotic centrosomes";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"RHO GTPases Activate Formins";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Formation of tubulin folding intermediates by CCT/TriC";"Mitotic Prometaphase";"EML4 and NUDC in mitotic spindle formation";"COPI-dependent Golgi-to-ER retrograde traffic";"Post-chaperonin tubulin folding pathway";"Separation of Sister Chromatids";"Cilium Assembly";"Aggrephagy";"RHO GTPases activate IQGAPs";"MHC class II antigen presentation";"Gap junction assembly";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"COPI-mediated anterograde transport";"Activation of AMPK downstream of NMDARs";"Recycling pathway of L1";"HCMV Early Events";"COPI-independent Golgi-to-ER retrograde traffic";"Carboxyterminal post-translational modifications of tubulin";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Kinesins";"Assembly and cell surface presentation of NMDA receptors"
Medex_00032535-RA	7	KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1	"Thermogenesis";"Relaxin signaling pathway";"Human cytomegalovirus infection";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"mTOR signaling pathway";"PI3K-Akt signaling pathway"
Medex_00047031-RA	1	Reactome: R-HSA-8949664	"Processing of SMDT1"
Medex_00031561-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Medex_00072729-RA	1	Reactome: R-HSA-8963889	"Assembly of active LPL and LIPC lipase complexes"
Medex_00028097-RA	1	Reactome: R-HSA-2132295	"MHC class II antigen presentation"
Medex_00053783-RA	4	MetaCyc: PWY-7805;Reactome: R-HSA-71737;MetaCyc: PWY-7807;KEGG: 00190+3.6.1.1	"(aminomethyl)phosphonate degradation";"Pyrophosphate hydrolysis";"Glyphosate degradation III";"Oxidative phosphorylation"
Medex_00019537-RA	10	MetaCyc: PWY-7411;MetaCyc: PWY-7587;MetaCyc: PWY-5667;MetaCyc: PWY-8055;KEGG: 00561+2.3.1.15;KEGG: 00564+2.3.1.15;MetaCyc: PWY-8051;MetaCyc: PWY-6453;MetaCyc: PWY-8053;Reactome: R-HSA-1483166	"Phosphatidate biosynthesis (yeast)";"Oleate biosynthesis III (cyanobacteria)";"CDP-diacylglycerol biosynthesis I";"Palmitoyl ethanolamide biosynthesis";"Glycerolipid metabolism";"Glycerophospholipid metabolism";"Anandamide biosynthesis I";"Stigma estolide biosynthesis";"Anandamide biosynthesis II";"Synthesis of PA"
Medex_00003501-RA	1	Reactome: R-HSA-3238698	"WNT ligand biogenesis and trafficking"
Medex_00010995-RA	1	Reactome: R-HSA-5620912	"Anchoring of the basal body to the plasma membrane"
Medex_00045519-RA	3	KEGG: 00790+4.1.99.22;MetaCyc: PWY-6823;Reactome: R-HSA-947581	"Folate biosynthesis";"Molybdenum cofactor biosynthesis";"Molybdenum cofactor biosynthesis"
Medex_00084679-RA	1	Reactome: R-HSA-2428928	"IRS-related events triggered by IGF1R"
Medex_00064281-RA	4	Reactome: R-HSA-189483;MetaCyc: PWY-6972;Reactome: R-HSA-5679001;Reactome: R-HSA-382556	"Heme degradation";"Oleandomycin activation/inactivation";"Defective ABCC2 causes Dubin-Johnson syndrome";"ABC-family proteins mediated transport"
Medex_00051159-RA	6	MetaCyc: PWY-5884;Reactome: R-HSA-9640463;KEGG: 00073+1.2.1.84;MetaCyc: PWY-7782;MetaCyc: PWY-7656;MetaCyc: PWY-6733	"Wax esters biosynthesis I";"Wax biosynthesis";"Cutin, suberine and wax biosynthesis";"Plasmalogen biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Sporopollenin precursors biosynthesis"
Medex_00039781-RA	27	Reactome: R-HSA-9610379;Reactome: R-HSA-5619107;Reactome: R-HSA-9609690;Reactome: R-HSA-4551638;Reactome: R-HSA-6784531;Reactome: R-HSA-3108214;Reactome: R-HSA-159236;Reactome: R-HSA-191859;Reactome: R-HSA-168325;Reactome: R-HSA-180910;Reactome: R-HSA-168271;Reactome: R-HSA-3301854;Reactome: R-HSA-3232142;Reactome: R-HSA-4085377;Reactome: R-HSA-4570464;Reactome: R-HSA-170822;Reactome: R-HSA-159230;Reactome: R-HSA-4615885;Reactome: R-HSA-3371453;Reactome: R-HSA-168276;Reactome: R-HSA-5578749;Reactome: R-HSA-168333;Reactome: R-HSA-1169408;Reactome: R-HSA-165054;Reactome: R-HSA-159231;Reactome: R-HSA-159227;Reactome: R-HSA-180746	"HCMV Late Events";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"HCMV Early Events";"SUMOylation of chromatin organization proteins";"tRNA processing in the nucleus";"SUMOylation of DNA damage response and repair proteins";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"snRNP Assembly";"Viral Messenger RNA Synthesis";"Vpr-mediated nuclear import of PICs";"Transport of Ribonucleoproteins into the Host Nucleus";"Nuclear Pore Complex (NPC) Disassembly";"SUMOylation of ubiquitinylation proteins";"SUMOylation of SUMOylation proteins";"SUMOylation of RNA binding proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Transport of the SLBP Dependant Mature mRNA";"SUMOylation of DNA replication proteins";"Regulation of HSF1-mediated heat shock response";"NS1 Mediated Effects on Host Pathways";"Transcriptional regulation by small RNAs";"NEP/NS2 Interacts with the Cellular Export Machinery";"ISG15 antiviral mechanism";"Rev-mediated nuclear export of HIV RNA";"Transport of Mature mRNA Derived from an Intronless Transcript";"Transport of the SLBP independent Mature mRNA";"Nuclear import of Rev protein"
Medex_00072455-RA	1	Reactome: R-HSA-611105	"Respiratory electron transport"
Medex_00006284-RA	6	Reactome: R-HSA-72689;Reactome: R-HSA-72706;Reactome: R-HSA-156827;Reactome: R-HSA-72695;Reactome: R-HSA-72702;Reactome: R-HSA-72649	"Formation of a pool of free 40S subunits";"GTP hydrolysis and joining of the 60S ribosomal subunit";"L13a-mediated translational silencing of Ceruloplasmin expression";"Formation of the ternary complex, and subsequently, the 43S complex";"Ribosomal scanning and start codon recognition";"Translation initiation complex formation"
Medex_00029446-RA	1	Reactome: R-HSA-373080	"Class B/2 (Secretin family receptors)"
Medex_00060333-RA	8	MetaCyc: PWY-6664;MetaCyc: PWY-4661;Reactome: R-HSA-1855183;MetaCyc: PWY-2301;KEGG: 00562+5.5.1.4;MetaCyc: PWY-6580;KEGG: 00521+5.5.1.4;MetaCyc: PWY-6372	"Di-myo-inositol phosphate biosynthesis";"1D-myo-inositol hexakisphosphate biosynthesis III (Spirodela polyrrhiza)";"Synthesis of IP2, IP, and Ins in the cytosol";"Myo-inositol biosynthesis";"Inositol phosphate metabolism";"Phosphatidylinositol biosynthesis I (bacteria)";"Streptomycin biosynthesis";"1D-myo-inositol hexakisphosphate biosynthesis IV (Dictyostelium)"
Medex_00079709-RA	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
Medex_00016621-RA	6	Reactome: R-HSA-5696400;Reactome: R-HSA-5696395;Reactome: R-HSA-6782135;Reactome: R-HSA-6783310;Reactome: R-HSA-6798695;Reactome: R-HSA-5685938	"Dual Incision in GG-NER";"Formation of Incision Complex in GG-NER";"Dual incision in TC-NER";"Fanconi Anemia Pathway";"Neutrophil degranulation";"HDR through Single Strand Annealing (SSA)"
Medex_00065850-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Medex_00000565-RA	1	KEGG: 00480+3.4.11.2	"Glutathione metabolism"
Medex_00039986-RA	2	Reactome: R-HSA-163282;Reactome: R-HSA-2151201	"Mitochondrial transcription initiation";"Transcriptional activation of mitochondrial biogenesis"
Medex_00014618-RA	2	Reactome: R-HSA-8949215;Reactome: R-HSA-8949664	"Mitochondrial calcium ion transport";"Processing of SMDT1"
Medex_00023358-RA	1	Reactome: R-HSA-5689877	"Josephin domain DUBs"
Medex_00028713-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Medex_00032464-RA	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840	"Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation"
Medex_00015569-RA	3	Reactome: R-HSA-1362409;Reactome: R-HSA-1268020;KEGG: 00860+1.16.3.1	"Mitochondrial iron-sulfur cluster biogenesis";"Mitochondrial protein import";"Porphyrin and chlorophyll metabolism"
Medex_00045379-RA	1	MetaCyc: PWY-6829	"Trna methylation (yeast)"
Medex_00015719-RA	2	Reactome: R-HSA-380270;Reactome: R-HSA-380320	"Recruitment of mitotic centrosome proteins and complexes";"Recruitment of NuMA to mitotic centrosomes"
Medex_00082675-RA	2	KEGG: 00561+2.3.1.20;KEGG: 00073+2.3.1.20	"Glycerolipid metabolism";"Cutin, suberine and wax biosynthesis"
Medex_00021691-RA	1	Reactome: R-HSA-211981	"Xenobiotics"
Medex_00012394-RA	2	Reactome: R-HSA-6811438;Reactome: R-HSA-6807878	"Intra-Golgi traffic";"COPI-mediated anterograde transport"
Medex_00017815-RA	1	Reactome: R-HSA-8856828	"Clathrin-mediated endocytosis"
Medex_00020197-RA	1	Reactome: R-HSA-8849932	"Synaptic adhesion-like molecules"
Medex_00042568-RA	1	Reactome: R-HSA-211945	"Phase I - Functionalization of compounds"
Medex_00077795-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00047828-RA	3	KEGG: 00330+1.14.11.2;Reactome: R-HSA-1650814;MetaCyc: PWY-7894	"Arginine and proline metabolism";"Collagen biosynthesis and modifying enzymes";"Procollagen hydroxylation and glycosylation"
Medex_00061340-RA	1	Reactome: R-HSA-9609523	"Insertion of tail-anchored proteins into the endoplasmic reticulum membrane"
Medex_00090106-RA	40	KEGG: 00310+4.2.1.17+1.1.1.35;MetaCyc: PWY-7726;MetaCyc: PWY-7094;MetaCyc: PWY-6863;MetaCyc: PWY-5136;MetaCyc: PWY-7654;MetaCyc: PWY-7778;KEGG: 00062+4.2.1.17+1.1.1.35;KEGG: 00360+4.2.1.17;KEGG: 00903+4.2.1.17;KEGG: 00380+4.2.1.17+1.1.1.35;MetaCyc: PWY-6945;MetaCyc: PWY-6883;MetaCyc: PWY-7606;KEGG: 00627+4.2.1.17;KEGG: 00280+4.2.1.17+1.1.1.35;KEGG: 00623+1.1.1.35;KEGG: 00071+4.2.1.17+1.1.1.35;MetaCyc: PWY-6946;MetaCyc: PWY-5177;MetaCyc: PWY-7779;KEGG: 00650+4.2.1.17+1.1.1.35;KEGG: 00640+4.2.1.17;MetaCyc: PWY-7656;MetaCyc: PWY-7007;MetaCyc: PWY-7216;KEGG: 00930+4.2.1.17+1.1.1.35;MetaCyc: PWY-6435;MetaCyc: PWY-5789;KEGG: 00720+4.2.1.17+1.1.1.35;MetaCyc: PWY-6583;MetaCyc: PWY-5109;KEGG: 00281+4.2.1.17+1.1.1.35;KEGG: 00362+4.2.1.17+1.1.1.35;MetaCyc: PWY-7401;MetaCyc: PWY-6944;MetaCyc: PWY-5138;KEGG: 00592+4.2.1.17;KEGG: 00410+4.2.1.17;MetaCyc: PWY-1361	"Lysine degradation";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"Fatty acid salvage";"Pyruvate fermentation to hexanol (engineered)";"Fatty acid beta-oxidation II (plant peroxisome)";"(8E,10E)-dodeca-8,10-dienol biosynthesis";"2-methylpropene degradation";"Fatty acid elongation";"Phenylalanine metabolism";"Limonene and pinene degradation";"Tryptophan metabolism";"Cholesterol degradation to androstenedione I (cholesterol oxidase)";"Pyruvate fermentation to butanol II (engineered)";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Aminobenzoate degradation";"Valine, leucine and isoleucine degradation";"Toluene degradation";"Fatty acid degradation";"Cholesterol degradation to androstenedione II (cholesterol dehydrogenase)";"Glutaryl-coa degradation";"Methyl tert-butyl ether degradation";"Butanoate metabolism";"Propanoate metabolism";"Spodoptera littoralis pheromone biosynthesis";"Methyl ketone biosynthesis (engineered)";"(R)- and (S)-3-hydroxybutanoate biosynthesis (engineered)";"Caprolactam degradation";"4-hydroxybenzoate biosynthesis III (plants)";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Carbon fixation pathways in prokaryotes";"Pyruvate fermentation to butanol I";"Fermentation to 2-methylbutanoate";"Geraniol degradation";"Benzoate degradation";"Crotonate fermentation (to acetate and cyclohexane carboxylate)";"Androstenedione degradation";"Fatty acid beta-oxidation IV (unsaturated, even number)";"alpha-Linolenic acid metabolism";"beta-Alanine metabolism";"Benzoyl-coa degradation I (aerobic)"
Medex_00050044-RA	6	KEGG: 00040+1.1.1.22;KEGG: 00520+1.1.1.22;KEGG: 00053+1.1.1.22;MetaCyc: PWY-7346;MetaCyc: PWY-7820;Reactome: R-HSA-173599	"Pentose and glucuronate interconversions";"Amino sugar and nucleotide sugar metabolism";"Ascorbate and aldarate metabolism";"UDP-alpha-D-glucuronate biosynthesis (from UDP-glucose)";"Teichuronic acid biosynthesis (B. subtilis 168)";"Formation of the active cofactor, UDP-glucuronate"
Medex_00026560-RA	2	Reactome: R-HSA-390522;Reactome: R-HSA-445355	"Striated Muscle Contraction";"Smooth Muscle Contraction"
Medex_00089105-RA	2	KEGG: 00500+3.2.1.28;Reactome: R-HSA-189085	"Starch and sucrose metabolism";"Digestion of dietary carbohydrate"
Medex_00008300-RA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Medex_00023038-RA	2	KEGG: 00970+6.1.1.20;Reactome: R-HSA-379726	"Aminoacyl-tRNA biosynthesis";"Mitochondrial tRNA aminoacylation"
Medex_00076847-RA	3	MetaCyc: PWY-4361;Reactome: R-HSA-1237112;KEGG: 00270+1.13.11.54	"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I";"Methionine salvage pathway";"Cysteine and methionine metabolism"
Medex_00062961-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00043025-RA	11	KEGG: 00480+1.1.1.42;MetaCyc: PWY-6549;KEGG: 00720+1.1.1.42;MetaCyc: PWY-7124;KEGG: 00020+1.1.1.42;MetaCyc: PWY-7268;Reactome: R-HSA-71403;MetaCyc: PWY-6728;MetaCyc: PWY-6969;MetaCyc: PWY-5913;MetaCyc: PWY-7254	"Glutathione metabolism";"L-glutamine biosynthesis III";"Carbon fixation pathways in prokaryotes";"Ethylene biosynthesis V (engineered)";"Citrate cycle (TCA cycle)";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"Citric acid cycle (TCA cycle)";"Methylaspartate cycle";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Partial TCA cycle (obligate autotrophs)";"TCA cycle VII (acetate-producers)"
Medex_00087051-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00093431-RA	42	Reactome: R-HSA-69473;Reactome: R-HSA-8936459;Reactome: R-HSA-5625886;Reactome: R-HSA-3214842;Reactome: R-HSA-110330;Reactome: R-HSA-5693565;Reactome: R-HSA-3214815;Reactome: R-HSA-8939236;Reactome: R-HSA-5693607;Reactome: R-HSA-73772;Reactome: R-HSA-73728;Reactome: R-HSA-3214847;Reactome: R-HSA-427413;Reactome: R-HSA-201722;Reactome: R-HSA-4551638;Reactome: R-HSA-9616222;Reactome: R-HSA-912446;Reactome: R-HSA-2559582;Reactome: R-HSA-5578749;Reactome: R-HSA-3214841;Reactome: R-HSA-3214858;Reactome: R-HSA-427389;Reactome: R-HSA-9018519;Reactome: R-HSA-5617472;Reactome: R-HSA-2559586;Reactome: R-HSA-1221632;Reactome: R-HSA-5250924;Reactome: R-HSA-110331;Reactome: R-HSA-212300;Reactome: R-HSA-606279;Reactome: R-HSA-171306;Reactome: R-HSA-110329;Reactome: R-HSA-2559580;Reactome: R-HSA-427359;Reactome: R-HSA-5334118;Reactome: R-HSA-9610379;Reactome: R-HSA-1912408;Reactome: R-HSA-5693571;Reactome: R-HSA-977225;Reactome: R-HSA-9609690;Reactome: R-HSA-2299718;Reactome: R-HSA-110328	"G2/M DNA damage checkpoint";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3";"HDMs demethylate histones";"Recognition and association of DNA glycosylase with site containing an affected purine";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"HDACs deacetylate histones";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Processing of DNA double-strand break ends";"RNA Polymerase I Promoter Escape";"RNA Polymerase I Promoter Opening";"HATs acetylate histones";"NoRC negatively regulates rRNA expression";"Formation of the beta-catenin:TCF transactivating complex";"SUMOylation of chromatin organization proteins";"Transcriptional regulation of granulopoiesis";"Meiotic recombination";"Senescence-Associated Secretory Phenotype (SASP)";"Transcriptional regulation by small RNAs";"PKMTs methylate histone lysines";"RMTs methylate histone arginines";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"Estrogen-dependent gene expression";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"DNA Damage/Telomere Stress Induced Senescence";"Meiotic synapsis";"B-WICH complex positively regulates rRNA expression";"Cleavage of the damaged purine";"PRC2 methylates histones and DNA";"Deposition of new CENPA-containing nucleosomes at the centromere";"Packaging Of Telomere Ends";"Cleavage of the damaged pyrimidine";"Oxidative Stress Induced Senescence";"SIRT1 negatively regulates rRNA expression";"DNA methylation";"HCMV Late Events";"Pre-NOTCH Transcription and Translation";"Nonhomologous End-Joining (NHEJ)";"Amyloid fiber formation";"HCMV Early Events";"Condensation of Prophase Chromosomes";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine"
Medex_00028176-RA	2	Reactome: R-HSA-8936459;Reactome: R-HSA-3214841	"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"PKMTs methylate histone lysines"
Medex_00078341-RA	12	MetaCyc: PWY-1042;KEGG: 00680+4.1.2.13;MetaCyc: PWY-6142;KEGG: 00030+4.1.2.13;Reactome: R-HSA-70263;Reactome: R-HSA-70171;MetaCyc: PWY-5484;MetaCyc: PWY-1861;KEGG: 00710+4.1.2.13;MetaCyc: PWY-7385;KEGG: 00051+4.1.2.13;KEGG: 00010+4.1.2.13	"Glycolysis IV (plant cytosol)";"Methane metabolism";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Pentose phosphate pathway";"Gluconeogenesis";"Glycolysis";"Glycolysis II (from fructose 6-phosphate)";"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"Carbon fixation in photosynthetic organisms";"1,3-propanediol biosynthesis (engineered)";"Fructose and mannose metabolism";"Glycolysis / Gluconeogenesis"
Medex_00005994-RA	1	Reactome: R-HSA-8949664	"Processing of SMDT1"
Medex_00047221-RA	3	Reactome: R-HSA-76061;Reactome: R-HSA-749476;Reactome: R-HSA-76066	"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 2 Promoter"
Medex_00019536-RA	10	MetaCyc: PWY-5667;KEGG: 00561+2.3.1.15;MetaCyc: PWY-8055;MetaCyc: PWY-7411;MetaCyc: PWY-7587;MetaCyc: PWY-8053;Reactome: R-HSA-1483166;MetaCyc: PWY-6453;KEGG: 00564+2.3.1.15;MetaCyc: PWY-8051	"CDP-diacylglycerol biosynthesis I";"Glycerolipid metabolism";"Palmitoyl ethanolamide biosynthesis";"Phosphatidate biosynthesis (yeast)";"Oleate biosynthesis III (cyanobacteria)";"Anandamide biosynthesis II";"Synthesis of PA";"Stigma estolide biosynthesis";"Glycerophospholipid metabolism";"Anandamide biosynthesis I"
Medex_00054948-RA	3	KEGG: 00270+5.3.1.23;MetaCyc: PWY-4361;MetaCyc: PWY-7174	"Cysteine and methionine metabolism";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation II"
Medex_00035954-RA	15	Reactome: R-HSA-912631;Reactome: R-HSA-2219530;Reactome: R-HSA-389357;Reactome: R-HSA-1433557;Reactome: R-HSA-8853659;Reactome: R-HSA-416476;Reactome: R-HSA-388841;Reactome: R-HSA-6811558;Reactome: R-HSA-912526;Reactome: R-HSA-114604;Reactome: R-HSA-1266695;Reactome: R-HSA-1257604;Reactome: R-HSA-1660499;Reactome: R-HSA-9009391;Reactome: R-HSA-512988	"Regulation of signaling by CBL";"Constitutive Signaling by Aberrant PI3K in Cancer";"CD28 dependent PI3K/Akt signaling";"Signaling by SCF-KIT";"RET signaling";"G alpha (q) signalling events";"Costimulation by the CD28 family";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"Interleukin receptor SHC signaling";"GPVI-mediated activation cascade";"Interleukin-7 signaling";"PIP3 activates AKT signaling";"Synthesis of PIPs at the plasma membrane";"Extra-nuclear estrogen signaling";"Interleukin-3, Interleukin-5 and GM-CSF signaling"
Medex_00012352-RA	1	Reactome: R-HSA-110362	"POLB-Dependent Long Patch Base Excision Repair"
Medex_00073954-RA	13	Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-9633012;Reactome: R-HSA-156902;Reactome: R-HSA-1799339;Reactome: R-HSA-192823;Reactome: R-HSA-975957;Reactome: R-HSA-6791226;Reactome: R-HSA-2408557;Reactome: R-HSA-72764;Reactome: R-HSA-72689;Reactome: R-HSA-975956;Reactome: R-HSA-72706	"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Peptide chain elongation";"SRP-dependent cotranslational protein targeting to membrane";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"Selenocysteine synthesis";"Eukaryotic Translation Termination";"Formation of a pool of free 40S subunits";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit"
Medex_00071066-RA	4	Reactome: R-HSA-5576892;Reactome: R-HSA-112308;Reactome: R-HSA-419037;Reactome: R-HSA-5576893	"Phase 0 - rapid depolarisation";"Presynaptic depolarization and calcium channel opening";"NCAM1 interactions";"Phase 2 - plateau phase"
Medex_00026838-RA	1	Reactome: R-HSA-6790901	"rRNA modification in the nucleus and cytosol"
Medex_00077657-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Medex_00065562-RA	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
Medex_00019088-RA	16	Reactome: R-HSA-1799339;Reactome: R-HSA-9633012;Reactome: R-HSA-975957;Reactome: R-HSA-72702;Reactome: R-HSA-6791226;Reactome: R-HSA-975956;Reactome: R-HSA-72706;Reactome: R-HSA-72764;Reactome: R-HSA-72649;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-72695;Reactome: R-HSA-156902;Reactome: R-HSA-192823;Reactome: R-HSA-2408557;Reactome: R-HSA-72689	"SRP-dependent cotranslational protein targeting to membrane";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Ribosomal scanning and start codon recognition";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Eukaryotic Translation Termination";"Translation initiation complex formation";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Formation of the ternary complex, and subsequently, the 43S complex";"Peptide chain elongation";"Viral mRNA Translation";"Selenocysteine synthesis";"Formation of a pool of free 40S subunits"
Medex_00036306-RA	5	KEGG: 00310+1.2.4.2;MetaCyc: PWY-5084;KEGG: 00020+1.2.4.2;Reactome: R-HSA-389661;KEGG: 00380+1.2.4.2	"Lysine degradation";"2-oxoglutarate decarboxylation to succinyl-CoA";"Citrate cycle (TCA cycle)";"Glyoxylate metabolism and glycine degradation";"Tryptophan metabolism"
Medex_00007541-RA	4	KEGG: 00513+2.4.1.257+2.4.1.132;Reactome: R-HSA-446193;KEGG: 00510+2.4.1.257+2.4.1.132;Reactome: R-HSA-4549349	"Various types of N-glycan biosynthesis";"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"N-Glycan biosynthesis";"Defective ALG2 causes ALG2-CDG (CDG-1i)"
Medex_00014463-RA	2	Reactome: R-HSA-3299685;MetaCyc: PWY-6854	"Detoxification of Reactive Oxygen Species";"Ethylene biosynthesis III (microbes)"
Medex_00037145-RA	1	Reactome: R-HSA-6798163	"Choline catabolism"
Medex_00048039-RA	1	KEGG: 00760+2.3.1.286	"Nicotinate and nicotinamide metabolism"
Medex_00082367-RA	5	KEGG: 00513+2.4.1.68;KEGG: 00533+2.4.1.68;KEGG: 00510+2.4.1.68;Reactome: R-HSA-975578;MetaCyc: PWY-7426	"Various types of N-glycan biosynthesis";"Glycosaminoglycan biosynthesis - keratan sulfate";"N-Glycan biosynthesis";"Reactions specific to the complex N-glycan synthesis pathway";"Complex N-linked glycan biosynthesis (vertebrates)"
Medex_00092231-RA	2	Reactome: R-HSA-456926;Reactome: R-HSA-416482	"Thrombin signalling through proteinase activated receptors (PARs)";"G alpha (12/13) signalling events"
Medex_00013772-RA	1	Reactome: R-HSA-425561	"Sodium/Calcium exchangers"
Medex_00048049-RA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00063020-RA	3	Reactome: R-HSA-70350;Reactome: R-HSA-5657562;KEGG: 00051+2.7.1.3	"Fructose catabolism";"Essential fructosuria";"Fructose and mannose metabolism"
Medex_00041063-RA	1	MetaCyc: PWY-7437	"Protein O-[N-acetyl]-glucosylation"
Medex_00017166-RA	57	Reactome: R-HSA-187577;Reactome: R-HSA-174084;Reactome: R-HSA-1236974;Reactome: R-HSA-8854050;Reactome: R-HSA-5610783;Reactome: R-HSA-174113;Reactome: R-HSA-4641257;Reactome: R-HSA-69481;Reactome: R-HSA-5678895;Reactome: R-HSA-350562;Reactome: R-HSA-68827;Reactome: R-HSA-8948751;Reactome: R-HSA-9604323;Reactome: R-HSA-69017;Reactome: R-HSA-1234176;Reactome: R-HSA-532668;Reactome: R-HSA-5362768;Reactome: R-HSA-69601;Reactome: R-HSA-5676590;Reactome: R-HSA-174184;Reactome: R-HSA-5607764;Reactome: R-HSA-1169091;Reactome: R-HSA-174154;Reactome: R-HSA-8951664;Reactome: R-HSA-2871837;Reactome: R-HSA-983168;Reactome: R-HSA-202424;Reactome: R-HSA-5658442;Reactome: R-HSA-5358346;Reactome: R-HSA-8941858;Reactome: R-HSA-9020702;Reactome: R-HSA-180585;Reactome: R-HSA-450408;Reactome: R-HSA-4641258;Reactome: R-HSA-2467813;Reactome: R-HSA-9010553;Reactome: R-HSA-68949;Reactome: R-HSA-211733;Reactome: R-HSA-382556;Reactome: R-HSA-8939236;Reactome: R-HSA-195253;Reactome: R-HSA-8939902;Reactome: R-HSA-75815;Reactome: R-HSA-5687128;Reactome: R-HSA-5668541;Reactome: R-HSA-5689603;Reactome: R-HSA-4608870;Reactome: R-HSA-5610785;Reactome: R-HSA-5689880;Reactome: R-HSA-1236978;Reactome: R-HSA-349425;Reactome: R-HSA-180534;Reactome: R-HSA-5632684;Reactome: R-HSA-174178;Reactome: R-HSA-5607761;Reactome: R-HSA-5610780;Reactome: R-HSA-8852276	"SCF(Skp2)-mediated degradation of p27/p21";"Autodegradation of Cdh1 by Cdh1:APC/C";"ER-Phagosome pathway";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Degradation of GLI2 by the proteasome";"SCF-beta-TrCP mediated degradation of Emi1";"Degradation of AXIN";"G2/M Checkpoints";"Defective CFTR causes cystic fibrosis";"Regulation of ornithine decarboxylase (ODC)";"CDT1 association with the CDC6:ORC:origin complex";"Regulation of PTEN stability and activity";"Negative regulation of NOTCH4 signaling";"CDK-mediated phosphorylation and removal of Cdc6";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"N-glycan trimming in the ER and Calnexin/Calreticulin cycle";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"NIK-->noncanonical NF-kB signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"CLEC7A (Dectin-1) signaling";"Activation of NF-kappaB in B cells";"APC/C:Cdc20 mediated degradation of Securin";"Neddylation";"FCERI mediated NF-kB activation";"Antigen processing: Ubiquitination & Proteasome degradation";"Downstream TCR signaling";"Regulation of RAS by GAPs";"Hedgehog ligand biogenesis";"Regulation of RUNX3 expression and activity";"Interleukin-1 signaling";"Vif-mediated degradation of APOBEC3G";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Degradation of DVL";"Separation of Sister Chromatids";"Regulation of expression of SLITs and ROBOs";"Orc1 removal from chromatin";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"ABC-family proteins mediated transport";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Degradation of beta-catenin by the destruction complex";"Regulation of RUNX2 expression and activity";"Ubiquitin-dependent degradation of Cyclin D";"MAPK6/MAPK4 signaling";"TNFR2 non-canonical NF-kB pathway";"UCH proteinases";"Asymmetric localization of PCP proteins";"GLI3 is processed to GLI3R by the proteasome";"Ub-specific processing proteases";"Cross-presentation of soluble exogenous antigens (endosomes)";"Autodegradation of the E3 ubiquitin ligase COP1";"Vpu mediated degradation of CD4";"Hedgehog 'on' state";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Dectin-1 mediated noncanonical NF-kB signaling";"Degradation of GLI1 by the proteasome";"The role of GTSE1 in G2/M progression after G2 checkpoint"
Medex_00012854-RA	4	Reactome: R-HSA-73817;KEGG: 00230+6.3.4.4;KEGG: 00250+6.3.4.4;MetaCyc: PWY-7219	"Purine ribonucleoside monophosphate biosynthesis";"Purine metabolism";"Alanine, aspartate and glutamate metabolism";"Adenosine ribonucleotides de novo biosynthesis"
Medex_00051385-RA	5	Reactome: R-HSA-72187;Reactome: R-HSA-73856;Reactome: R-HSA-77595;Reactome: R-HSA-72163;Reactome: R-HSA-6784531	"mRNA 3'-end processing";"RNA Polymerase II Transcription Termination";"Processing of Intronless Pre-mRNAs";"mRNA Splicing - Major Pathway";"tRNA processing in the nucleus"
Medex_00009605-RA	1	Reactome: R-HSA-6811440	"Retrograde transport at the Trans-Golgi-Network"
Medex_00033851-RA	1	Reactome: R-HSA-379716	"Cytosolic tRNA aminoacylation"
Medex_00076963-RA	2	Reactome: R-HSA-5362517;Reactome: R-HSA-204174	"Signaling by Retinoic Acid";"Regulation of pyruvate dehydrogenase (PDH) complex"
Medex_00055564-RA	4	Reactome: R-HSA-5688399;Reactome: R-HSA-5683826;Reactome: R-HSA-5683678;Reactome: R-HSA-1369062	"Defective ABCA3 causes pulmonary surfactant metabolism dysfunction 3 (SMDP3)";"Surfactant metabolism";"Defective ABCA3 causes pulmonary surfactant metabolism dysfunction type 3 (SMDP3)";"ABC transporters in lipid homeostasis"
Medex_00029428-RA	2	Reactome: R-HSA-5689880;Reactome: R-HSA-5689603	"Ub-specific processing proteases";"UCH proteinases"
Medex_00084023-RA	2	MetaCyc: PWY-7379;MetaCyc: PWY-7375	"Mrna capping II";"Mrna capping I"
Medex_00046349-RA	3	Reactome: R-HSA-983168;Reactome: R-HSA-390471;Reactome: R-HSA-8951664	"Antigen processing: Ubiquitination & Proteasome degradation";"Association of TriC/CCT with target proteins during biosynthesis";"Neddylation"
Medex_00012476-RA	2	Reactome: R-HSA-8866423;Reactome: R-HSA-8963888	"VLDL assembly";"Chylomicron assembly"
Medex_00048486-RA	3	Reactome: R-HSA-159236;Reactome: R-HSA-73856;Reactome: R-HSA-72187	"Transport of Mature mRNA derived from an Intron-Containing Transcript";"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing"
Medex_00041908-RA	2	Reactome: R-HSA-6798695;Reactome: R-HSA-8951664	"Neutrophil degranulation";"Neddylation"
Medex_00093695-RA	3	KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway"
Medex_00072485-RA	1	Reactome: R-HSA-3108214	"SUMOylation of DNA damage response and repair proteins"
Medex_00069821-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Medex_00038513-RA	1	Reactome: R-HSA-5693607	"Processing of DNA double-strand break ends"
Medex_00060155-RA	1	Reactome: R-HSA-380320	"Recruitment of NuMA to mitotic centrosomes"
Medex_00018269-RA	1	Reactome: R-HSA-947581	"Molybdenum cofactor biosynthesis"
Medex_00069328-RA	2	Reactome: R-HSA-1482798;Reactome: R-HSA-1268020	"Acyl chain remodeling of CL";"Mitochondrial protein import"
Medex_00081820-RA	14	MetaCyc: PWY-5080;MetaCyc: PWY-8041;MetaCyc: PWY-7725;MetaCyc: PWY-6598;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7601;MetaCyc: PWY-7724;MetaCyc: PWY-7035;Reactome: R-HSA-75876;MetaCyc: PWY-5972;MetaCyc: PWY-7602;MetaCyc: PWY-7619;MetaCyc: PWY-7036;MetaCyc: PWY-6433	"Very long chain fatty acid biosynthesis I";"Ultra-long-chain fatty acid biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Sciadonate biosynthesis";"Fatty acid elongation";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"(9Z)-tricosene biosynthesis";"Synthesis of very long-chain fatty acyl-CoAs";"Stearate biosynthesis I (animals)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Juniperonate biosynthesis";"Very long chain fatty acid biosynthesis II";"Hydroxylated fatty acid biosynthesis (plants)"
Medex_00020334-RA	7	MetaCyc: PWY-1722;MetaCyc: PWY-3841;KEGG: 00670+6.3.4.3;MetaCyc: PWY-2161;Reactome: R-HSA-196757;MetaCyc: PWY-2201;KEGG: 00720+6.3.4.3	"Formate assimilation into 5,10-methylenetetrahydrofolate";"Folate transformations II (plants)";"One carbon pool by folate";"Folate polyglutamylation";"Metabolism of folate and pterines";"Folate transformations I";"Carbon fixation pathways in prokaryotes"
Medex_00000169-RA	16	Reactome: R-HSA-176407;Reactome: R-HSA-69017;Reactome: R-HSA-174154;Reactome: R-HSA-8853884;Reactome: R-HSA-174184;Reactome: R-HSA-176412;Reactome: R-HSA-174178;Reactome: R-HSA-141430;Reactome: R-HSA-176408;Reactome: R-HSA-174048;Reactome: R-HSA-983168;Reactome: R-HSA-2559582;Reactome: R-HSA-174084;Reactome: R-HSA-2467813;Reactome: R-HSA-176409;Reactome: R-HSA-179409	"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"CDK-mediated phosphorylation and removal of Cdc6";"APC/C:Cdc20 mediated degradation of Securin";"Transcriptional Regulation by VENTX";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Phosphorylation of the APC/C";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Inactivation of APC/C via direct inhibition of the APC/C complex";"Regulation of APC/C activators between G1/S and early anaphase";"APC/C:Cdc20 mediated degradation of Cyclin B";"Antigen processing: Ubiquitination & Proteasome degradation";"Senescence-Associated Secretory Phenotype (SASP)";"Autodegradation of Cdh1 by Cdh1:APC/C";"Separation of Sister Chromatids";"APC/C:Cdc20 mediated degradation of mitotic proteins";"APC-Cdc20 mediated degradation of Nek2A"
Medex_00096780-RA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
Medex_00044466-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00022683-RA	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
Medex_00037400-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00046619-RA	1	Reactome: R-HSA-203927	"MicroRNA (miRNA) biogenesis"
Medex_00031869-RA	3	MetaCyc: PWY-6348;KEGG: 00740+3.1.3.2;KEGG: 00730+3.1.3.2	"Phosphate acquisition";"Riboflavin metabolism";"Thiamine metabolism"
Medex_00018561-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00078719-RA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00047490-RA	1	Reactome: R-HSA-5419276	"Mitochondrial translation termination"
Medex_00099370-RA	4	Reactome: R-HSA-1632852;Reactome: R-HSA-6798695;Reactome: R-HSA-6802952;Reactome: R-HSA-983168	"Macroautophagy";"Neutrophil degranulation";"Signaling by BRAF and RAF fusions";"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00016708-RA	6	Reactome: R-HSA-73772;Reactome: R-HSA-73863;Reactome: R-HSA-5250924;Reactome: R-HSA-427413;Reactome: R-HSA-427359;Reactome: R-HSA-73762	"RNA Polymerase I Promoter Escape";"RNA Polymerase I Transcription Termination";"B-WICH complex positively regulates rRNA expression";"NoRC negatively regulates rRNA expression";"SIRT1 negatively regulates rRNA expression";"RNA Polymerase I Transcription Initiation"
Medex_00066216-RA	1	Reactome: R-HSA-6809371	"Formation of the cornified envelope"
Medex_00039378-RA	9	Reactome: R-HSA-5696400;Reactome: R-HSA-6782135;Reactome: R-HSA-110314;Reactome: R-HSA-5696394;Reactome: R-HSA-6782210;Reactome: R-HSA-5696395;Reactome: R-HSA-6781823;Reactome: R-HSA-6781827;Reactome: R-HSA-8951664	"Dual Incision in GG-NER";"Dual incision in TC-NER";"Recognition of DNA damage by PCNA-containing replication complex";"DNA Damage Recognition in GG-NER";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Formation of Incision Complex in GG-NER";"Formation of TC-NER Pre-Incision Complex";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Neddylation"
Medex_00011884-RA	6	Reactome: R-HSA-912446;Reactome: R-HSA-5358606;Reactome: R-HSA-6796648;Reactome: R-HSA-5632987;Reactome: R-HSA-5545483;Reactome: R-HSA-5358565	"Meiotic recombination";"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"TP53 Regulates Transcription of DNA Repair Genes";"Defective Mismatch Repair Associated With PMS2";"Defective Mismatch Repair Associated With MLH1";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)"
Medex_00016544-RA	1	Reactome: R-HSA-9609523	"Insertion of tail-anchored proteins into the endoplasmic reticulum membrane"
Medex_00040126-RA	1	Reactome: R-HSA-6798163	"Choline catabolism"
Medex_00039376-RA	1	Reactome: R-HSA-8951664	"Neddylation"
Medex_00088808-RA	1	Reactome: R-HSA-71403	"Citric acid cycle (TCA cycle)"
Medex_00083796-RA	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
Medex_00019651-RA	4	Reactome: R-HSA-674695;Reactome: R-HSA-112382;Reactome: R-HSA-8866654;Reactome: R-HSA-75955	"RNA Polymerase II Pre-transcription Events";"Formation of RNA Pol II elongation complex";"E3 ubiquitin ligases ubiquitinate target proteins";"RNA Polymerase II Transcription Elongation"
Medex_00029836-RA	3	Reactome: R-HSA-5689603;Reactome: R-HSA-3214847;Reactome: R-HSA-2151201	"UCH proteinases";"HATs acetylate histones";"Transcriptional activation of mitochondrial biogenesis"
Medex_00066926-RA	1	Reactome: R-HSA-204005	"COPII-mediated vesicle transport"
Medex_00031154-RA	6	Reactome: R-HSA-428930;Reactome: R-HSA-418592;Reactome: R-HSA-399997;Reactome: R-HSA-434316;Reactome: R-HSA-416476;Reactome: R-HSA-456926	"Thromboxane signalling through TP receptor";"ADP signalling through P2Y purinoceptor 1";"Acetylcholine regulates insulin secretion";"Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion";"G alpha (q) signalling events";"Thrombin signalling through proteinase activated receptors (PARs)"
Medex_00044365-RA	6	KEGG: 00260+5.4.2.11;MetaCyc: PWY-8004;MetaCyc: PWY-5484;KEGG: 00010+5.4.2.11;KEGG: 00680+5.4.2.11;MetaCyc: PWY-1622	"Glycine, serine and threonine metabolism";"Entner-Doudoroff pathway I";"Glycolysis II (from fructose 6-phosphate)";"Glycolysis / Gluconeogenesis";"Methane metabolism";"Formaldehyde assimilation I (serine pathway)"
Medex_00045009-RA	2	Reactome: R-HSA-2408522;Reactome: R-HSA-379716	"Selenoamino acid metabolism";"Cytosolic tRNA aminoacylation"
Medex_00057557-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Medex_00037439-RA	6	KEGG: 00330+2.7.2.11+1.2.1.41;MetaCyc: PWY-6922;Reactome: R-HSA-8964539;KEGG: 00332+2.7.2.11+1.2.1.41;KEGG: 00330+2.7.2.11;KEGG: 00332+2.7.2.11	"Arginine and proline metabolism";"L-Ndelta-acetylornithine biosynthesis";"Glutamate and glutamine metabolism";"Carbapenem biosynthesis";"Arginine and proline metabolism";"Carbapenem biosynthesis"
Medex_00003012-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Medex_00011286-RA	1	Reactome: R-HSA-5625900	"RHO GTPases activate CIT"
Medex_00034952-RA	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276	"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination"
Medex_00025931-RA	2	Reactome: R-HSA-6814122;Reactome: R-HSA-418594	"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"G alpha (i) signalling events"
Medex_00049561-RA	1	Reactome: R-HSA-163765	"ChREBP activates metabolic gene expression"
Medex_00023719-RA	3	Reactome: R-HSA-4724325;Reactome: R-HSA-446193;KEGG: 00510+2.4.1.265	"Defective ALG8 causes ALG8-CDG (CDG-1h)";"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"N-Glycan biosynthesis"
Medex_00091723-RA	4	Reactome: R-HSA-167160;Reactome: R-HSA-77075;MetaCyc: PWY-7375;Reactome: R-HSA-72086	"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"RNA Pol II CTD phosphorylation and interaction with CE";"Mrna capping I";"mRNA Capping"
Medex_00017829-RA	1	KEGG: 04660+2.7.10.2	"T cell receptor signaling pathway"
Medex_00093142-RA	2	Reactome: R-HSA-72702;Reactome: R-HSA-72706	"Ribosomal scanning and start codon recognition";"GTP hydrolysis and joining of the 60S ribosomal subunit"
Medex_00021397-RA	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
Medex_00064067-RA	6	Reactome: R-HSA-3299685;Reactome: R-HSA-9615017;KEGG: 00380+1.11.1.6;Reactome: R-HSA-9033241;KEGG: 00630+1.11.1.6;Reactome: R-HSA-6798695	"Detoxification of Reactive Oxygen Species";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"Tryptophan metabolism";"Peroxisomal protein import";"Glyoxylate and dicarboxylate metabolism";"Neutrophil degranulation"
Medex_00045152-RA	29	Reactome: R-HSA-3371453;Reactome: R-HSA-2559586;Reactome: R-HSA-5693568;Reactome: R-HSA-5693565;Reactome: R-HSA-6803204;KEGG: 05163+2.7.11.1;Reactome: R-HSA-69541;Reactome: R-HSA-69473;KEGG: 04151+2.7.11.1;Reactome: R-HSA-6804756;Reactome: R-HSA-5693579;KEGG: 04714+2.7.11.1;Reactome: R-HSA-6803207;Reactome: R-HSA-6804760;Reactome: R-HSA-5693607;Reactome: R-HSA-5685938;KEGG: 04150+2.7.11.1;KEGG: 04926+2.7.11.1;Reactome: R-HSA-6796648;Reactome: R-HSA-6804757;Reactome: R-HSA-5693571;Reactome: R-HSA-5693548;Reactome: R-HSA-349425;Reactome: R-HSA-5693616;Reactome: R-HSA-912446;Reactome: R-HSA-5693554;KEGG: 05170+2.7.11.1;Reactome: R-HSA-5685942;KEGG: 05165+2.7.11.1	"Regulation of HSF1-mediated heat shock response";"DNA Damage/Telomere Stress Induced Senescence";"Resolution of D-loop Structures through Holliday Junction Intermediates";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"TP53 Regulates Transcription of Genes Involved in Cytochrome C Release";"Human cytomegalovirus infection";"Stabilization of p53";"G2/M DNA damage checkpoint";"PI3K-Akt signaling pathway";"Regulation of TP53 Activity through Phosphorylation";"Homologous DNA Pairing and Strand Exchange";"Thermogenesis";"TP53 Regulates Transcription of Caspase Activators and Caspases";"Regulation of TP53 Activity through Methylation";"Processing of DNA double-strand break ends";"HDR through Single Strand Annealing (SSA)";"mTOR signaling pathway";"Relaxin signaling pathway";"TP53 Regulates Transcription of DNA Repair Genes";"Regulation of TP53 Degradation";"Nonhomologous End-Joining (NHEJ)";"Sensing of DNA Double Strand Breaks";"Autodegradation of the E3 ubiquitin ligase COP1";"Presynaptic phase of homologous DNA pairing and strand exchange";"Meiotic recombination";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Human immunodeficiency virus 1 infection";"HDR through Homologous Recombination (HRR)";"Human papillomavirus infection"
Medex_00038363-RA	1	Reactome: R-HSA-418594	"G alpha (i) signalling events"
Medex_00047408-RA	2	Reactome: R-HSA-1660662;Reactome: R-HSA-390471	"Glycosphingolipid metabolism";"Association of TriC/CCT with target proteins during biosynthesis"
Medex_00004923-RA	18	Reactome: R-HSA-167246;Reactome: R-HSA-167160;Reactome: R-HSA-167200;Reactome: R-HSA-75955;Reactome: R-HSA-167152;Reactome: R-HSA-674695;Reactome: R-HSA-167243;Reactome: R-HSA-167287;Reactome: R-HSA-167290;Reactome: R-HSA-167242;Reactome: R-HSA-77075;Reactome: R-HSA-6796648;Reactome: R-HSA-167238;Reactome: R-HSA-72086;Reactome: R-HSA-112382;Reactome: R-HSA-6807505;Reactome: R-HSA-113418;Reactome: R-HSA-167158	"Tat-mediated elongation of the HIV-1 transcript";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Polymerase II Transcription Elongation";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Polymerase II Pre-transcription Events";"Tat-mediated HIV elongation arrest and recovery";"HIV elongation arrest and recovery";"Pausing and recovery of HIV elongation";"Abortive elongation of HIV-1 transcript in the absence of Tat";"RNA Pol II CTD phosphorylation and interaction with CE";"TP53 Regulates Transcription of DNA Repair Genes";"Pausing and recovery of Tat-mediated HIV elongation";"mRNA Capping";"Formation of RNA Pol II elongation complex";"RNA polymerase II transcribes snRNA genes";"Formation of the Early Elongation Complex";"Formation of the HIV-1 Early Elongation Complex"
Medex_00009083-RA	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840	"Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation"
Medex_00053987-RA	1	Reactome: R-HSA-9633012	"Response of EIF2AK4 (GCN2) to amino acid deficiency"
Medex_00007627-RA	11	Reactome: R-HSA-9013508;Reactome: R-HSA-2173796;Reactome: R-HSA-2894862;Reactome: R-HSA-1912408;Reactome: R-HSA-210744;Reactome: R-HSA-350054;Reactome: R-HSA-8941856;Reactome: R-HSA-72163;Reactome: R-HSA-2644606;Reactome: R-HSA-2122947;Reactome: R-HSA-9013695	"NOTCH3 Intracellular Domain Regulates Transcription";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Pre-NOTCH Transcription and Translation";"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"Notch-HLH transcription pathway";"RUNX3 regulates NOTCH signaling";"mRNA Splicing - Major Pathway";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH1 Intracellular Domain Regulates Transcription";"NOTCH4 Intracellular Domain Regulates Transcription"
Medex_00082338-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Medex_00067843-RA	10	Reactome: R-HSA-1989781;Reactome: R-HSA-400253;Reactome: R-HSA-400206;Reactome: R-HSA-1368082;Reactome: R-HSA-3214858;Reactome: R-HSA-1368108;Reactome: R-HSA-381340;Reactome: R-HSA-2426168;Reactome: R-HSA-2151201;Reactome: R-HSA-8939243	"PPARA activates gene expression";"Circadian Clock";"Regulation of lipid metabolism by PPARalpha";"RORA activates gene expression";"RMTs methylate histone arginines";"BMAL1:CLOCK,NPAS2 activates circadian gene expression";"Transcriptional regulation of white adipocyte differentiation";"Activation of gene expression by SREBF (SREBP)";"Transcriptional activation of mitochondrial biogenesis";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"
Medex_00044171-RA	1	Reactome: R-HSA-6804760	"Regulation of TP53 Activity through Methylation"
Medex_00091969-RA	9	Reactome: R-HSA-1474151;MetaCyc: PWY-6983;MetaCyc: PWY-7852;MetaCyc: PWY-6703;KEGG: 00790+3.5.4.16;MetaCyc: PWY-5664;MetaCyc: PWY-7442;MetaCyc: PWY-6147;MetaCyc: PWY-5663	"Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation";"Threo-tetrahydrobiopterin biosynthesis";"6-hydroxymethyl-dihydropterin diphosphate biosynthesis IV (Plasmodium)";"Preq0 biosynthesis";"Folate biosynthesis";"Erythro-tetrahydrobiopterin biosynthesis II";"Drosopterin and aurodrosopterin biosynthesis";"6-hydroxymethyl-dihydropterin diphosphate biosynthesis I";"Erythro-tetrahydrobiopterin biosynthesis I"
Medex_00000488-RA	2	Reactome: R-HSA-390471;Reactome: R-HSA-1660662	"Association of TriC/CCT with target proteins during biosynthesis";"Glycosphingolipid metabolism"
Medex_00030240-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Medex_00012871-RA	1	Reactome: R-HSA-5635838	"Activation of SMO"
Medex_00092550-RA	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
Medex_00059312-RA	7	Reactome: R-HSA-3000178;Reactome: R-HSA-3000171;Reactome: R-HSA-5173105;Reactome: R-HSA-9010553;Reactome: R-HSA-5083629;Reactome: R-HSA-5083633;Reactome: R-HSA-5083628	"ECM proteoglycans";"Non-integrin membrane-ECM interactions";"O-linked glycosylation";"Regulation of expression of SLITs and ROBOs";"Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2";"Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1";"Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3"
Medex_00042709-RA	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
Medex_00027428-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Medex_00006301-RA	1	Reactome: R-HSA-8951664	"Neddylation"
Medex_00052798-RA	1	Reactome: R-HSA-3214815	"HDACs deacetylate histones"
Medex_00042058-RA	1	Reactome: R-HSA-5676934	"Protein repair"
Medex_00015205-RA	6	Reactome: R-HSA-6791226;Reactome: R-HSA-450513;Reactome: R-HSA-450385;Reactome: R-HSA-450604;Reactome: R-HSA-380994;Reactome: R-HSA-429958	"Major pathway of rRNA processing in the nucleolus and cytosol";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"KSRP (KHSRP) binds and destabilizes mRNA";"ATF4 activates genes in response to endoplasmic reticulum stress";"mRNA decay by 3' to 5' exoribonuclease"
Medex_00050013-RA	11	MetaCyc: PWY-6963;KEGG: 00220+6.3.1.2;Reactome: R-HSA-210455;KEGG: 00250+6.3.1.2;MetaCyc: PWY-5675;Reactome: R-HSA-8964539;MetaCyc: PWY-381;KEGG: 00630+6.3.1.2;KEGG: 00910+6.3.1.2;MetaCyc: PWY-6549;MetaCyc: PWY-6964	"Ammonia assimilation cycle I";"Arginine biosynthesis";"Astrocytic Glutamate-Glutamine Uptake And Metabolism";"Alanine, aspartate and glutamate metabolism";"Nitrate reduction V (assimilatory)";"Glutamate and glutamine metabolism";"Nitrate reduction II (assimilatory)";"Glyoxylate and dicarboxylate metabolism";"Nitrogen metabolism";"L-glutamine biosynthesis III";"Ammonia assimilation cycle II"
Medex_00063510-RA	1	Reactome: R-HSA-5658442	"Regulation of RAS by GAPs"
Medex_00062995-RA	5	Reactome: R-HSA-5693571;Reactome: R-HSA-5693565;Reactome: R-HSA-5689901;Reactome: R-HSA-5693607;Reactome: R-HSA-69473	"Nonhomologous End-Joining (NHEJ)";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Metalloprotease DUBs";"Processing of DNA double-strand break ends";"G2/M DNA damage checkpoint"
Medex_00012803-RA	2	Reactome: R-HSA-382556;Reactome: R-HSA-5690338	"ABC-family proteins mediated transport";"Defective ABCC6 causes pseudoxanthoma elasticum (PXE)"
Medex_00065011-RA	1	Reactome: R-HSA-6794361	"Neurexins and neuroligins"
Medex_00006525-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Medex_00045266-RA	1	Reactome: R-HSA-400253	"Circadian Clock"
Medex_00049042-RA	9	Reactome: R-HSA-73776;Reactome: R-HSA-674695;Reactome: R-HSA-167172;Reactome: R-HSA-75953;Reactome: R-HSA-167161;Reactome: R-HSA-6804756;Reactome: R-HSA-73779;Reactome: R-HSA-76042;Reactome: R-HSA-167162	"RNA Polymerase II Promoter Escape";"RNA Polymerase II Pre-transcription Events";"Transcription of the HIV genome";"RNA Polymerase II Transcription Initiation";"HIV Transcription Initiation";"Regulation of TP53 Activity through Phosphorylation";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II HIV Promoter Escape"
Medex_00042109-RA	1	Reactome: R-HSA-2132295	"MHC class II antigen presentation"
Medex_00079205-RA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
Medex_00001660-RA	1	Reactome: R-HSA-162791	"Attachment of GPI anchor to uPAR"
Medex_00003600-RA	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00065879-RA	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
Medex_00027032-RA	56	Reactome: R-HSA-202424;Reactome: R-HSA-983168;Reactome: R-HSA-8941858;Reactome: R-HSA-5358346;Reactome: R-HSA-5658442;Reactome: R-HSA-9020702;Reactome: R-HSA-450408;Reactome: R-HSA-180585;Reactome: R-HSA-2467813;Reactome: R-HSA-4641258;Reactome: R-HSA-8939236;Reactome: R-HSA-68949;Reactome: R-HSA-382556;Reactome: R-HSA-211733;Reactome: R-HSA-9010553;Reactome: R-HSA-195253;Reactome: R-HSA-75815;Reactome: R-HSA-8939902;Reactome: R-HSA-4608870;Reactome: R-HSA-5689603;Reactome: R-HSA-5687128;Reactome: R-HSA-5668541;Reactome: R-HSA-5610785;Reactome: R-HSA-5689880;Reactome: R-HSA-180534;Reactome: R-HSA-1236978;Reactome: R-HSA-349425;Reactome: R-HSA-5632684;Reactome: R-HSA-174178;Reactome: R-HSA-8852276;Reactome: R-HSA-5610780;Reactome: R-HSA-5607761;Reactome: R-HSA-174084;Reactome: R-HSA-187577;Reactome: R-HSA-8854050;Reactome: R-HSA-1236974;Reactome: R-HSA-5610783;Reactome: R-HSA-4641257;Reactome: R-HSA-174113;Reactome: R-HSA-5678895;Reactome: R-HSA-69481;Reactome: R-HSA-350562;Reactome: R-HSA-8948751;Reactome: R-HSA-68827;Reactome: R-HSA-9604323;Reactome: R-HSA-5676590;Reactome: R-HSA-69017;Reactome: R-HSA-5362768;Reactome: R-HSA-1234176;Reactome: R-HSA-69601;Reactome: R-HSA-5607764;Reactome: R-HSA-174184;Reactome: R-HSA-174154;Reactome: R-HSA-1169091;Reactome: R-HSA-2871837;Reactome: R-HSA-8951664	"Downstream TCR signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Regulation of RUNX3 expression and activity";"Hedgehog ligand biogenesis";"Regulation of RAS by GAPs";"Interleukin-1 signaling";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Vif-mediated degradation of APOBEC3G";"Separation of Sister Chromatids";"Degradation of DVL";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Orc1 removal from chromatin";"ABC-family proteins mediated transport";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Regulation of expression of SLITs and ROBOs";"Degradation of beta-catenin by the destruction complex";"Ubiquitin-dependent degradation of Cyclin D";"Regulation of RUNX2 expression and activity";"Asymmetric localization of PCP proteins";"UCH proteinases";"MAPK6/MAPK4 signaling";"TNFR2 non-canonical NF-kB pathway";"GLI3 is processed to GLI3R by the proteasome";"Ub-specific processing proteases";"Vpu mediated degradation of CD4";"Cross-presentation of soluble exogenous antigens (endosomes)";"Autodegradation of the E3 ubiquitin ligase COP1";"Hedgehog 'on' state";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Degradation of GLI1 by the proteasome";"Dectin-1 mediated noncanonical NF-kB signaling";"Autodegradation of Cdh1 by Cdh1:APC/C";"SCF(Skp2)-mediated degradation of p27/p21";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"ER-Phagosome pathway";"Degradation of GLI2 by the proteasome";"Degradation of AXIN";"SCF-beta-TrCP mediated degradation of Emi1";"Defective CFTR causes cystic fibrosis";"G2/M Checkpoints";"Regulation of ornithine decarboxylase (ODC)";"Regulation of PTEN stability and activity";"CDT1 association with the CDC6:ORC:origin complex";"Negative regulation of NOTCH4 signaling";"NIK-->noncanonical NF-kB signaling";"CDK-mediated phosphorylation and removal of Cdc6";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"CLEC7A (Dectin-1) signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"APC/C:Cdc20 mediated degradation of Securin";"Activation of NF-kappaB in B cells";"FCERI mediated NF-kB activation";"Neddylation"
Medex_00073260-RA	1	Reactome: R-HSA-6799198	"Complex I biogenesis"
Medex_00043171-RA	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00043256-RA	26	Reactome: R-HSA-1912408;Reactome: R-HSA-1989781;Reactome: R-HSA-400253;Reactome: R-HSA-9013508;Reactome: R-HSA-3214847;Reactome: R-HSA-201722;Reactome: R-HSA-2644606;Reactome: R-HSA-9617629;Reactome: R-HSA-3134973;Reactome: R-HSA-8941856;Reactome: R-HSA-1368082;Reactome: R-HSA-9018519;Reactome: R-HSA-918233;Reactome: R-HSA-3371568;Reactome: R-HSA-5617472;Reactome: R-HSA-5621575;Reactome: R-HSA-933541;Reactome: R-HSA-2894862;Reactome: R-HSA-3899300;Reactome: R-HSA-2122947;Reactome: R-HSA-9013695;Reactome: R-HSA-381340;Reactome: R-HSA-9614657;Reactome: R-HSA-1234158;Reactome: R-HSA-8866907;Reactome: R-HSA-210744	"Pre-NOTCH Transcription and Translation";"PPARA activates gene expression";"Circadian Clock";"NOTCH3 Intracellular Domain Regulates Transcription";"HATs acetylate histones";"Formation of the beta-catenin:TCF transactivating complex";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Regulation of FOXO transcriptional activity by acetylation";"LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production";"RUNX3 regulates NOTCH signaling";"RORA activates gene expression";"Estrogen-dependent gene expression";"TRAF3-dependent IRF activation pathway";"Attenuation phase";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"CD209 (DC-SIGN) signaling";"TRAF6 mediated IRF7 activation";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"SUMOylation of transcription cofactors";"NOTCH1 Intracellular Domain Regulates Transcription";"NOTCH4 Intracellular Domain Regulates Transcription";"Transcriptional regulation of white adipocyte differentiation";"FOXO-mediated transcription of cell death genes";"Regulation of gene expression by Hypoxia-inducible Factor";"Activation of the TFAP2 (AP-2) family of transcription factors";"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells"
Medex_00028250-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00007828-RA	2	Reactome: R-HSA-3299685;KEGG: 00480+1.11.1.15	"Detoxification of Reactive Oxygen Species";"Glutathione metabolism"
Medex_00086921-RA	1	Reactome: R-HSA-70221	"Glycogen breakdown (glycogenolysis)"
Medex_00005924-RA	7	Reactome: R-HSA-380972;Reactome: R-HSA-5628897;Reactome: R-HSA-5674400;Reactome: R-HSA-8854214;Reactome: R-HSA-165181;Reactome: R-HSA-198323;Reactome: R-HSA-1632852	"Energy dependent regulation of mTOR by LKB1-AMPK";"TP53 Regulates Metabolic Genes";"Constitutive Signaling by AKT1 E17K in Cancer";"TBC/RABGAPs";"Inhibition of TSC complex formation by PKB";"AKT phosphorylates targets in the cytosol";"Macroautophagy"
Medex_00023812-RA	1	Reactome: R-HSA-1362409	"Mitochondrial iron-sulfur cluster biogenesis"
Medex_00059015-RA	5	Reactome: R-HSA-199220;Reactome: R-HSA-9029558;Reactome: R-HSA-75105;Reactome: R-HSA-2426168;Reactome: R-HSA-163765	"Vitamin B5 (pantothenate) metabolism";"NR1H2 & NR1H3 regulate gene expression linked to lipogenesis";"Fatty acyl-CoA biosynthesis";"Activation of gene expression by SREBF (SREBP)";"ChREBP activates metabolic gene expression"
Medex_00089545-RA	6	KEGG: 00195+7.1.2.2;KEGG: 00190+7.1.2.2;Reactome: R-HSA-1268020;Reactome: R-HSA-8949613;MetaCyc: PWY-7980;Reactome: R-HSA-163210	"Photosynthesis";"Oxidative phosphorylation";"Mitochondrial protein import";"Cristae formation";"ATP biosynthesis";"Formation of ATP by chemiosmotic coupling"
Medex_00025493-RA	1	Reactome: R-HSA-6804754	"Regulation of TP53 Expression"
Medex_00016772-RA	4	Reactome: R-HSA-5693579;Reactome: R-HSA-5685942;Reactome: R-HSA-5693554;Reactome: R-HSA-5693568	"Homologous DNA Pairing and Strand Exchange";"HDR through Homologous Recombination (HRR)";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Resolution of D-loop Structures through Holliday Junction Intermediates"
Medex_00015577-RA	2	Reactome: R-HSA-909733;Reactome: R-HSA-8983711	"Interferon alpha/beta signaling";"OAS antiviral response"
Medex_00099653-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Medex_00091834-RA	2	Reactome: R-HSA-1268020;Reactome: R-HSA-8949664	"Mitochondrial protein import";"Processing of SMDT1"
Medex_00054578-RA	1	Reactome: R-HSA-71384	"Ethanol oxidation"
Medex_00038541-RA	1	KEGG: 04660+2.7.10.2	"T cell receptor signaling pathway"
Medex_00030542-RA	7	MetaCyc: PWY-6123;KEGG: 00250+4.3.2.2;MetaCyc: PWY-6124;MetaCyc: PWY-7219;KEGG: 00230+4.3.2.2;MetaCyc: PWY-7234;Reactome: R-HSA-73817	"Inosine-5'-phosphate biosynthesis I";"Alanine, aspartate and glutamate metabolism";"Inosine-5'-phosphate biosynthesis II";"Adenosine ribonucleotides de novo biosynthesis";"Purine metabolism";"Inosine-5'-phosphate biosynthesis III";"Purine ribonucleoside monophosphate biosynthesis"
Medex_00057672-RA	52	Reactome: R-HSA-73762;Reactome: R-HSA-6803529;Reactome: R-HSA-6781827;Reactome: R-HSA-167158;Reactome: R-HSA-427413;Reactome: R-HSA-72203;Reactome: R-HSA-168325;Reactome: R-HSA-77075;Reactome: R-HSA-167238;Reactome: R-HSA-6796648;Reactome: R-HSA-72086;Reactome: R-HSA-674695;Reactome: R-HSA-167152;Reactome: R-HSA-73776;Reactome: R-HSA-73863;Reactome: R-HSA-167287;Reactome: R-HSA-167243;Reactome: R-HSA-73772;Reactome: R-HSA-6782210;Reactome: R-HSA-76061;Reactome: R-HSA-72165;Reactome: R-HSA-73780;Reactome: R-HSA-167162;Reactome: R-HSA-76042;Reactome: R-HSA-6807505;Reactome: R-HSA-1834949;Reactome: R-HSA-113418;Reactome: R-HSA-75953;Reactome: R-HSA-167161;Reactome: R-HSA-8851708;Reactome: R-HSA-73980;Reactome: R-HSA-76071;Reactome: R-HSA-112382;Reactome: R-HSA-73779;Reactome: R-HSA-749476;Reactome: R-HSA-76066;Reactome: R-HSA-5250924;Reactome: R-HSA-72163;Reactome: R-HSA-6781823;Reactome: R-HSA-167172;Reactome: R-HSA-167290;Reactome: R-HSA-167242;Reactome: R-HSA-167160;Reactome: R-HSA-167246;Reactome: R-HSA-5578749;Reactome: R-HSA-167200;Reactome: R-HSA-9018519;Reactome: R-HSA-75955;Reactome: R-HSA-6782135;Reactome: R-HSA-203927;Reactome: R-HSA-5617472;Reactome: R-HSA-5601884	"RNA Polymerase I Transcription Initiation";"FGFR2 alternative splicing";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Formation of the HIV-1 Early Elongation Complex";"NoRC negatively regulates rRNA expression";"Processing of Capped Intron-Containing Pre-mRNA";"Viral Messenger RNA Synthesis";"RNA Pol II CTD phosphorylation and interaction with CE";"Pausing and recovery of Tat-mediated HIV elongation";"TP53 Regulates Transcription of DNA Repair Genes";"mRNA Capping";"RNA Polymerase II Pre-transcription Events";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Polymerase II Promoter Escape";"RNA Polymerase I Transcription Termination";"HIV elongation arrest and recovery";"Tat-mediated HIV elongation arrest and recovery";"RNA Polymerase I Promoter Escape";"Gap-filling DNA repair synthesis and ligation in TC-NER";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"mRNA Splicing - Minor Pathway";"RNA Polymerase III Chain Elongation";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA polymerase II transcribes snRNA genes";"Cytosolic sensors of pathogen-associated DNA";"Formation of the Early Elongation Complex";"RNA Polymerase II Transcription Initiation";"HIV Transcription Initiation";"Signaling by FGFR2 IIIa TM";"RNA Polymerase III Transcription Termination";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"Formation of RNA Pol II elongation complex";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"B-WICH complex positively regulates rRNA expression";"mRNA Splicing - Major Pathway";"Formation of TC-NER Pre-Incision Complex";"Transcription of the HIV genome";"Pausing and recovery of HIV elongation";"Abortive elongation of HIV-1 transcript in the absence of Tat";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Tat-mediated elongation of the HIV-1 transcript";"Transcriptional regulation by small RNAs";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Estrogen-dependent gene expression";"RNA Polymerase II Transcription Elongation";"Dual incision in TC-NER";"MicroRNA (miRNA) biogenesis";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"PIWI-interacting RNA (piRNA) biogenesis"
Medex_00083150-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Medex_00071797-RA	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
Medex_00044572-RA	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5419276;Reactome: R-HSA-5368286	"Mitochondrial translation elongation";"Mitochondrial translation termination";"Mitochondrial translation initiation"
Medex_00044655-RA	2	Reactome: R-HSA-379716;Reactome: R-HSA-2408522	"Cytosolic tRNA aminoacylation";"Selenoamino acid metabolism"
Medex_00071584-RA	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
Medex_00051357-RA	1	Reactome: R-HSA-211981	"Xenobiotics"
Medex_00056762-RA	8	Reactome: R-HSA-166208;Reactome: R-HSA-9639288;Reactome: R-HSA-1632852;Reactome: R-HSA-165159;Reactome: R-HSA-380972;Reactome: R-HSA-3371571;Reactome: R-HSA-8943724;Reactome: R-HSA-5628897	"mTORC1-mediated signalling";"Amino acids regulate mTORC1";"Macroautophagy";"mTOR signalling";"Energy dependent regulation of mTOR by LKB1-AMPK";"HSF1-dependent transactivation";"Regulation of PTEN gene transcription";"TP53 Regulates Metabolic Genes"
Medex_00044533-RA	1	Reactome: R-HSA-8849175	"Threonine catabolism"
Medex_00015641-RA	6	Reactome: R-HSA-5673001;Reactome: R-HSA-5654706;Reactome: R-HSA-5654700;Reactome: R-HSA-5654712;Reactome: R-HSA-9028731;Reactome: R-HSA-5654693	"RAF/MAP kinase cascade";"FRS-mediated FGFR3 signaling";"FRS-mediated FGFR2 signaling";"FRS-mediated FGFR4 signaling";"Activated NTRK2 signals through FRS2 and FRS3";"FRS-mediated FGFR1 signaling"
Medex_00013564-RA	2	Reactome: R-HSA-6811434;Reactome: R-HSA-6807878	"COPI-dependent Golgi-to-ER retrograde traffic";"COPI-mediated anterograde transport"
Medex_00041917-RA	4	KEGG: 00100+1.3.1.72;MetaCyc: PWY-8026;Reactome: R-HSA-6807047;Reactome: R-HSA-6807062	"Steroid biosynthesis";"Sterol biosynthesis (methylotrophs)";"Cholesterol biosynthesis via desmosterol";"Cholesterol biosynthesis via lathosterol"
Medex_00002382-RA	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
Medex_00095247-RA	1	Reactome: R-HSA-2173788	"Downregulation of TGF-beta receptor signaling"
Medex_00058204-RA	3	KEGG: 00790+3.1.3.1;MetaCyc: PWY-5491;KEGG: 00730+3.1.3.1	"Folate biosynthesis";"Diethylphosphate degradation";"Thiamine metabolism"
Medex_00055029-RA	1	Reactome: R-HSA-388844	"Receptor-type tyrosine-protein phosphatases"
Medex_00045427-RA	1	Reactome: R-HSA-420499	"Class C/3 (Metabotropic glutamate/pheromone receptors)"
Medex_00043827-RA	5	Reactome: R-HSA-4641257;MetaCyc: PWY-7511;Reactome: R-HSA-8948751;Reactome: R-HSA-201681;Reactome: R-HSA-5689880	"Degradation of AXIN";"Protein ubiquitination";"Regulation of PTEN stability and activity";"TCF dependent signaling in response to WNT";"Ub-specific processing proteases"
Medex_00014142-RA	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
MedexCellulase03-PA	2	KEGG: 00500+3.2.1.4;MetaCyc: PWY-6788	"Starch and sucrose metabolism";"Cellulose degradation II (fungi)"
Medex_00030252-RA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Medex_00057011-RA	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00048402-RA	2	KEGG: 00340+2.1.1.22;Reactome: R-HSA-70921	"Histidine metabolism";"Histidine catabolism"
Medex_00042600-RA	3	Reactome: R-HSA-5620916;Reactome: R-HSA-264876;Reactome: R-HSA-1445148	"VxPx cargo-targeting to cilium";"Insulin processing";"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
Medex_00050739-RA	14	Reactome: R-HSA-2467813;Reactome: R-HSA-380284;Reactome: R-HSA-380270;Reactome: R-HSA-9648025;Reactome: R-HSA-68877;Reactome: R-HSA-380259;Reactome: R-HSA-5663220;Reactome: R-HSA-5620912;Reactome: R-HSA-6811436;Reactome: R-HSA-380320;Reactome: R-HSA-2500257;Reactome: R-HSA-8854518;Reactome: R-HSA-141444;Reactome: R-HSA-2565942	"Separation of Sister Chromatids";"Loss of proteins required for interphase microtubule organization from the centrosome";"Recruitment of mitotic centrosome proteins and complexes";"EML4 and NUDC in mitotic spindle formation";"Mitotic Prometaphase";"Loss of Nlp from mitotic centrosomes";"RHO GTPases Activate Formins";"Anchoring of the basal body to the plasma membrane";"COPI-independent Golgi-to-ER retrograde traffic";"Recruitment of NuMA to mitotic centrosomes";"Resolution of Sister Chromatid Cohesion";"AURKA Activation by TPX2";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Regulation of PLK1 Activity at G2/M Transition"
Medex_00088433-RA	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5419276;Reactome: R-HSA-5389840	"Mitochondrial translation initiation";"Mitochondrial translation termination";"Mitochondrial translation elongation"
Medex_00014641-RA	3	MetaCyc: PWY-6348;KEGG: 00740+3.1.3.2;KEGG: 00730+3.1.3.2	"Phosphate acquisition";"Riboflavin metabolism";"Thiamine metabolism"
Medex_00071926-RA	1	Reactome: R-HSA-381753	"Olfactory Signaling Pathway"
Medex_00086118-RA	2	Reactome: R-HSA-8939243;Reactome: R-HSA-3214858	"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RMTs methylate histone arginines"
Medex_00089903-RA	7	KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1	"Human papillomavirus infection";"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Human cytomegalovirus infection";"Thermogenesis";"Relaxin signaling pathway"
Medex_00014415-RA	1	Reactome: R-HSA-388844	"Receptor-type tyrosine-protein phosphatases"
Medex_00025827-RA	1	Reactome: R-HSA-3295583	"TRP channels"
Medex_00042259-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00029705-RA	2	Reactome: R-HSA-6811436;Reactome: R-HSA-8876198	"COPI-independent Golgi-to-ER retrograde traffic";"RAB GEFs exchange GTP for GDP on RABs"
Medex_00030746-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Medex_00060276-RA	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00067616-RA	1	Reactome: R-HSA-975957	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
Medex_00078984-RA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00006592-RA	27	Reactome: R-HSA-4085377;Reactome: R-HSA-170822;Reactome: R-HSA-4570464;Reactome: R-HSA-168271;Reactome: R-HSA-180910;Reactome: R-HSA-3232142;Reactome: R-HSA-3301854;Reactome: R-HSA-3108214;Reactome: R-HSA-6784531;Reactome: R-HSA-168325;Reactome: R-HSA-159236;Reactome: R-HSA-191859;Reactome: R-HSA-9610379;Reactome: R-HSA-5619107;Reactome: R-HSA-4551638;Reactome: R-HSA-9609690;Reactome: R-HSA-159231;Reactome: R-HSA-180746;Reactome: R-HSA-159227;Reactome: R-HSA-1169408;Reactome: R-HSA-168333;Reactome: R-HSA-165054;Reactome: R-HSA-5578749;Reactome: R-HSA-168276;Reactome: R-HSA-4615885;Reactome: R-HSA-159230;Reactome: R-HSA-3371453	"SUMOylation of SUMOylation proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"SUMOylation of RNA binding proteins";"Transport of Ribonucleoproteins into the Host Nucleus";"Vpr-mediated nuclear import of PICs";"SUMOylation of ubiquitinylation proteins";"Nuclear Pore Complex (NPC) Disassembly";"SUMOylation of DNA damage response and repair proteins";"tRNA processing in the nucleus";"Viral Messenger RNA Synthesis";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"snRNP Assembly";"HCMV Late Events";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"SUMOylation of chromatin organization proteins";"HCMV Early Events";"Transport of Mature mRNA Derived from an Intronless Transcript";"Nuclear import of Rev protein";"Transport of the SLBP independent Mature mRNA";"ISG15 antiviral mechanism";"NEP/NS2 Interacts with the Cellular Export Machinery";"Rev-mediated nuclear export of HIV RNA";"Transcriptional regulation by small RNAs";"NS1 Mediated Effects on Host Pathways";"SUMOylation of DNA replication proteins";"Transport of the SLBP Dependant Mature mRNA";"Regulation of HSF1-mediated heat shock response"
Medex_00069245-RA	10	KEGG: 00670+1.5.1.5+3.5.4.9;MetaCyc: PWY-5497;MetaCyc: PWY-2201;MetaCyc: PWY-7909;Reactome: R-HSA-196757;MetaCyc: PWY-5030;MetaCyc: PWY-3841;MetaCyc: PWY-1722;MetaCyc: PWY-6613;KEGG: 00720+1.5.1.5+3.5.4.9	"One carbon pool by folate";"Purine nucleobases degradation II (anaerobic)";"Folate transformations I";"Formaldehyde oxidation VII (THF pathway)";"Metabolism of folate and pterines";"L-histidine degradation III";"Folate transformations II (plants)";"Formate assimilation into 5,10-methylenetetrahydrofolate";"Tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate";"Carbon fixation pathways in prokaryotes"
Medex_00039883-RA	1	Reactome: R-HSA-389957	"Prefoldin mediated transfer of substrate to CCT/TriC"
Medex_00074785-RA	2	KEGG: 00563+2.4.1.198;Reactome: R-HSA-162710	"Glycosylphosphatidylinositol (GPI)-anchor biosynthesis";"Synthesis of glycosylphosphatidylinositol (GPI)"
Medex_00017707-RA	3	Reactome: R-HSA-3000171;Reactome: R-HSA-8874081;Reactome: R-HSA-3000157	"Non-integrin membrane-ECM interactions";"MET activates PTK2 signaling";"Laminin interactions"
Medex_00000721-RA	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
MedexCellulase05-PA	2	KEGG: 00500+3.2.1.4;MetaCyc: PWY-6788	"Starch and sucrose metabolism";"Cellulose degradation II (fungi)"
Medex_00075687-RA	1	Reactome: R-HSA-71384	"Ethanol oxidation"
Medex_00093227-RA	1	Reactome: R-HSA-1655829	"Regulation of cholesterol biosynthesis by SREBP (SREBF)"
Medex_00007662-RA	1	Reactome: R-HSA-8949613	"Cristae formation"
Medex_00097160-RA	3	MetaCyc: PWY-6807;KEGG: 00511+3.2.1.51;Reactome: R-HSA-6798695	"Xyloglucan degradation II (exoglucanase)";"Other glycan degradation";"Neutrophil degranulation"
Medex_00006972-RA	2	Reactome: R-HSA-8949215;Reactome: R-HSA-8949664	"Mitochondrial calcium ion transport";"Processing of SMDT1"
Medex_00095763-RA	1	Reactome: R-HSA-389977	"Post-chaperonin tubulin folding pathway"
Medex_00004854-RA	2	Reactome: R-HSA-425366;Reactome: R-HSA-1483191	"Transport of bile salts and organic acids, metal ions and amine compounds";"Synthesis of PC"
Medex_00009570-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Medex_00094070-RA	18	MetaCyc: PWY-6638;MetaCyc: PWY-7115;MetaCyc: PWY-7383;MetaCyc: PWY-6642;KEGG: 00270+2.6.1.1;KEGG: 00350+2.6.1.1;KEGG: 00360+2.6.1.1;KEGG: 00220+2.6.1.1;MetaCyc: PWY-5913;MetaCyc: PWY-6643;KEGG: 00710+2.6.1.1;MetaCyc: PWY-7117;KEGG: 00250+2.6.1.1;KEGG: 00950+2.6.1.1;KEGG: 00401+2.6.1.1;KEGG: 00400+2.6.1.1;KEGG: 00330+2.6.1.1;KEGG: 00960+2.6.1.1	"Sulfolactate degradation III";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"Anaerobic energy metabolism (invertebrates, cytosol)";"(R)-cysteate degradation";"Cysteine and methionine metabolism";"Tyrosine metabolism";"Phenylalanine metabolism";"Arginine biosynthesis";"Partial TCA cycle (obligate autotrophs)";"Coenzyme M biosynthesis II";"Carbon fixation in photosynthetic organisms";"C4 photosynthetic carbon assimilation cycle, PEPCK type";"Alanine, aspartate and glutamate metabolism";"Isoquinoline alkaloid biosynthesis";"Novobiocin biosynthesis";"Phenylalanine, tyrosine and tryptophan biosynthesis";"Arginine and proline metabolism";"Tropane, piperidine and pyridine alkaloid biosynthesis"
Medex_00035402-RA	2	Reactome: R-HSA-390471;Reactome: R-HSA-1660662	"Association of TriC/CCT with target proteins during biosynthesis";"Glycosphingolipid metabolism"
Medex_00097298-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00016770-RA	4	Reactome: R-HSA-5693568;Reactome: R-HSA-5693554;Reactome: R-HSA-5685942;Reactome: R-HSA-5693579	"Resolution of D-loop Structures through Holliday Junction Intermediates";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"HDR through Homologous Recombination (HRR)";"Homologous DNA Pairing and Strand Exchange"
Medex_00068719-RA	3	KEGG: 00790+3.1.3.1;MetaCyc: PWY-5491;KEGG: 00730+3.1.3.1	"Folate biosynthesis";"Diethylphosphate degradation";"Thiamine metabolism"
Medex_00014255-RA	1	Reactome: R-HSA-2129379	"Molecules associated with elastic fibres"
Medex_00062715-RA	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00021203-RA	5	MetaCyc: PWY-6012-1;Reactome: R-HSA-199220;MetaCyc: PWY-6012;KEGG: 00770+2.7.8.7;MetaCyc: PWY-6289	"Acyl carrier protein activation";"Vitamin B5 (pantothenate) metabolism";"Acyl carrier protein metabolism";"Pantothenate and CoA biosynthesis";"Petrobactin biosynthesis"
Medex_00031932-RA	2	Reactome: R-HSA-3214858;Reactome: R-HSA-8939243	"RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"
Medex_00096370-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Medex_00063757-RA	26	Reactome: R-HSA-9013508;Reactome: R-HSA-3214847;Reactome: R-HSA-201722;Reactome: R-HSA-1912408;Reactome: R-HSA-1989781;Reactome: R-HSA-400253;Reactome: R-HSA-3134973;Reactome: R-HSA-8941856;Reactome: R-HSA-2644606;Reactome: R-HSA-9617629;Reactome: R-HSA-5621575;Reactome: R-HSA-933541;Reactome: R-HSA-2894862;Reactome: R-HSA-3899300;Reactome: R-HSA-1368082;Reactome: R-HSA-9018519;Reactome: R-HSA-3371568;Reactome: R-HSA-918233;Reactome: R-HSA-5617472;Reactome: R-HSA-210744;Reactome: R-HSA-9013695;Reactome: R-HSA-381340;Reactome: R-HSA-2122947;Reactome: R-HSA-8866907;Reactome: R-HSA-9614657;Reactome: R-HSA-1234158	"NOTCH3 Intracellular Domain Regulates Transcription";"HATs acetylate histones";"Formation of the beta-catenin:TCF transactivating complex";"Pre-NOTCH Transcription and Translation";"PPARA activates gene expression";"Circadian Clock";"LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production";"RUNX3 regulates NOTCH signaling";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Regulation of FOXO transcriptional activity by acetylation";"CD209 (DC-SIGN) signaling";"TRAF6 mediated IRF7 activation";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"SUMOylation of transcription cofactors";"RORA activates gene expression";"Estrogen-dependent gene expression";"Attenuation phase";"TRAF3-dependent IRF activation pathway";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"NOTCH4 Intracellular Domain Regulates Transcription";"Transcriptional regulation of white adipocyte differentiation";"NOTCH1 Intracellular Domain Regulates Transcription";"Activation of the TFAP2 (AP-2) family of transcription factors";"FOXO-mediated transcription of cell death genes";"Regulation of gene expression by Hypoxia-inducible Factor"
Medex_00039213-RA	8	KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;Reactome: R-HSA-2028269	"Relaxin signaling pathway";"Human cytomegalovirus infection";"PI3K-Akt signaling pathway";"Thermogenesis";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"Human papillomavirus infection";"Signaling by Hippo"
Medex_00009001-RA	1	KEGG: 00270+2.1.1.37	"Cysteine and methionine metabolism"
Medex_00074615-RA	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
Medex_00083872-RA	1	Reactome: R-HSA-5620922	"BBSome-mediated cargo-targeting to cilium"
Medex_00025389-RA	40	Reactome: R-HSA-72163;Reactome: R-HSA-167172;Reactome: R-HSA-167290;Reactome: R-HSA-6781823;Reactome: R-HSA-167242;Reactome: R-HSA-167246;Reactome: R-HSA-5578749;Reactome: R-HSA-167160;Reactome: R-HSA-167200;Reactome: R-HSA-75955;Reactome: R-HSA-9018519;Reactome: R-HSA-6782135;Reactome: R-HSA-203927;Reactome: R-HSA-5617472;Reactome: R-HSA-5601884;Reactome: R-HSA-6807505;Reactome: R-HSA-113418;Reactome: R-HSA-75953;Reactome: R-HSA-167161;Reactome: R-HSA-8851708;Reactome: R-HSA-112382;Reactome: R-HSA-73779;Reactome: R-HSA-674695;Reactome: R-HSA-167152;Reactome: R-HSA-73776;Reactome: R-HSA-167287;Reactome: R-HSA-167243;Reactome: R-HSA-6782210;Reactome: R-HSA-72165;Reactome: R-HSA-167162;Reactome: R-HSA-76042;Reactome: R-HSA-6803529;Reactome: R-HSA-6781827;Reactome: R-HSA-167158;Reactome: R-HSA-72203;Reactome: R-HSA-77075;Reactome: R-HSA-168325;Reactome: R-HSA-167238;Reactome: R-HSA-6796648;Reactome: R-HSA-72086	"mRNA Splicing - Major Pathway";"Transcription of the HIV genome";"Pausing and recovery of HIV elongation";"Formation of TC-NER Pre-Incision Complex";"Abortive elongation of HIV-1 transcript in the absence of Tat";"Tat-mediated elongation of the HIV-1 transcript";"Transcriptional regulation by small RNAs";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Polymerase II Transcription Elongation";"Estrogen-dependent gene expression";"Dual incision in TC-NER";"MicroRNA (miRNA) biogenesis";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"PIWI-interacting RNA (piRNA) biogenesis";"RNA polymerase II transcribes snRNA genes";"Formation of the Early Elongation Complex";"RNA Polymerase II Transcription Initiation";"HIV Transcription Initiation";"Signaling by FGFR2 IIIa TM";"Formation of RNA Pol II elongation complex";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase II Pre-transcription Events";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Polymerase II Promoter Escape";"HIV elongation arrest and recovery";"Tat-mediated HIV elongation arrest and recovery";"Gap-filling DNA repair synthesis and ligation in TC-NER";"mRNA Splicing - Minor Pathway";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"FGFR2 alternative splicing";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Formation of the HIV-1 Early Elongation Complex";"Processing of Capped Intron-Containing Pre-mRNA";"RNA Pol II CTD phosphorylation and interaction with CE";"Viral Messenger RNA Synthesis";"Pausing and recovery of Tat-mediated HIV elongation";"TP53 Regulates Transcription of DNA Repair Genes";"mRNA Capping"
Medex_00056705-RA	3	Reactome: R-HSA-5663213;Reactome: R-HSA-4420097;Reactome: R-HSA-2029482	"RHO GTPases Activate WASPs and WAVEs";"VEGFA-VEGFR2 Pathway";"Regulation of actin dynamics for phagocytic cup formation"
Medex_00054645-RA	7	MetaCyc: PWY-5469;MetaCyc: PWY-6824;MetaCyc: PWY-5461;KEGG: 00940+1.11.1.7;MetaCyc: PWY-7445;MetaCyc: PWY-7214;MetaCyc: PWY-5466	"Sesamin biosynthesis";"Justicidin B biosynthesis";"Betanidin degradation";"Phenylpropanoid biosynthesis";"Luteolin triglucuronide degradation";"Baicalein degradation (hydrogen peroxide detoxification)";"Matairesinol biosynthesis"
Medex_00012184-RA	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
Medex_00068502-RA	8	Reactome: R-HSA-68952;Reactome: R-HSA-69091;Reactome: R-HSA-174411;Reactome: R-HSA-69183;Reactome: R-HSA-68962;Reactome: R-HSA-113501;Reactome: R-HSA-69166;Reactome: R-HSA-174430	"DNA replication initiation";"Polymerase switching";"Polymerase switching on the C-strand of the telomere";"Processive synthesis on the lagging strand";"Activation of the pre-replicative complex";"Inhibition of replication initiation of damaged DNA by RB1/E2F1";"Removal of the Flap Intermediate";"Telomere C-strand synthesis initiation"
Medex_00083831-RA	7	Reactome: R-HSA-9018519;Reactome: R-HSA-3214815;Reactome: R-HSA-983231;Reactome: R-HSA-9029569;Reactome: R-HSA-5625886;Reactome: R-HSA-8943724;Reactome: R-HSA-3214842	"Estrogen-dependent gene expression";"HDACs deacetylate histones";"Factors involved in megakaryocyte development and platelet production";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3";"Regulation of PTEN gene transcription";"HDMs demethylate histones"
Medex_00043702-RA	1	Reactome: R-HSA-5658442	"Regulation of RAS by GAPs"
Medex_00060209-RA	2	MetaCyc: PWY-6502;Reactome: R-HSA-2393930	"8-oxo-(d)GTP detoxification I";"Phosphate bond hydrolysis by NUDT proteins"
Medex_00060703-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00078429-RA	3	Reactome: R-HSA-5689880;Reactome: R-HSA-201722;Reactome: R-HSA-3214847	"Ub-specific processing proteases";"Formation of the beta-catenin:TCF transactivating complex";"HATs acetylate histones"
Medex_00055644-RA	16	Reactome: R-HSA-72689;Reactome: R-HSA-2408557;Reactome: R-HSA-192823;Reactome: R-HSA-72649;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-72695;Reactome: R-HSA-156902;Reactome: R-HSA-975956;Reactome: R-HSA-72706;Reactome: R-HSA-72764;Reactome: R-HSA-72702;Reactome: R-HSA-6791226;Reactome: R-HSA-975957;Reactome: R-HSA-1799339;Reactome: R-HSA-9633012	"Formation of a pool of free 40S subunits";"Selenocysteine synthesis";"Viral mRNA Translation";"Translation initiation complex formation";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Formation of the ternary complex, and subsequently, the 43S complex";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Eukaryotic Translation Termination";"Ribosomal scanning and start codon recognition";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"Response of EIF2AK4 (GCN2) to amino acid deficiency"
Medex_00005793-RA	1	Reactome: R-HSA-6798163	"Choline catabolism"
Medex_00050903-RA	6	MetaCyc: PWY-5884;Reactome: R-HSA-9640463;MetaCyc: PWY-7782;MetaCyc: PWY-6733;MetaCyc: PWY-7656;KEGG: 00073+1.2.1.84	"Wax esters biosynthesis I";"Wax biosynthesis";"Plasmalogen biosynthesis";"Sporopollenin precursors biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Cutin, suberine and wax biosynthesis"
Medex_00007524-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Medex_00082195-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00022862-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Medex_00025771-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00045041-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Medex_00079189-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Medex_00040973-RA	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
Medex_00015862-RA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
Medex_00062852-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Medex_00034115-RA	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
Medex_00089814-RA	3	KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway"
Medex_00024907-RA	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
Medex_00014079-RA	2	Reactome: R-HSA-379716;Reactome: R-HSA-2408522	"Cytosolic tRNA aminoacylation";"Selenoamino acid metabolism"
Medex_00069332-RA	2	Reactome: R-HSA-383280;Reactome: R-HSA-983231	"Nuclear Receptor transcription pathway";"Factors involved in megakaryocyte development and platelet production"
Medex_00033076-RA	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
MedexCellulase02-PA	2	MetaCyc: PWY-6788;KEGG: 00500+3.2.1.4	"Cellulose degradation II (fungi)";"Starch and sucrose metabolism"
Medex_00060338-RA	7	KEGG: 00250+6.3.5.5;KEGG: 00240+6.3.5.5;MetaCyc: PWY-5154;MetaCyc: PWY-5686;MetaCyc: PWY-7790;MetaCyc: PWY-7791;MetaCyc: PWY-7400	"Alanine, aspartate and glutamate metabolism";"Pyrimidine metabolism";"L-arginine biosynthesis III (via N-acetyl-L-citrulline)";"UMP biosynthesis I";"UMP biosynthesis II";"UMP biosynthesis III";"L-arginine biosynthesis IV (archaebacteria)"
Medex_00012721-RA	3	KEGG: 00740+3.1.3.2;KEGG: 00730+3.1.3.2;MetaCyc: PWY-6348	"Riboflavin metabolism";"Thiamine metabolism";"Phosphate acquisition"
Medex_00022715-RA	1	Reactome: R-HSA-3299685	"Detoxification of Reactive Oxygen Species"
Medex_00030535-RA	2	Reactome: R-HSA-5357905;Reactome: R-HSA-5357956	"Regulation of TNFR1 signaling";"TNFR1-induced NFkappaB signaling pathway"
Medex_00059180-RA	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
Medex_00044465-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Medex_00024915-RA	30	Reactome: R-HSA-73772;Reactome: R-HSA-6781823;Reactome: R-HSA-167172;Reactome: R-HSA-6782210;Reactome: R-HSA-674695;Reactome: R-HSA-167152;Reactome: R-HSA-73776;Reactome: R-HSA-73863;Reactome: R-HSA-75955;Reactome: R-HSA-167162;Reactome: R-HSA-6782135;Reactome: R-HSA-76042;Reactome: R-HSA-167160;Reactome: R-HSA-167246;Reactome: R-HSA-2564830;Reactome: R-HSA-167200;Reactome: R-HSA-167161;Reactome: R-HSA-6781827;Reactome: R-HSA-75953;Reactome: R-HSA-167158;Reactome: R-HSA-5696395;Reactome: R-HSA-73762;Reactome: R-HSA-113418;Reactome: R-HSA-6796648;Reactome: R-HSA-112382;Reactome: R-HSA-73779;Reactome: R-HSA-72086;Reactome: R-HSA-5696400;Reactome: R-HSA-427413;Reactome: R-HSA-77075	"RNA Polymerase I Promoter Escape";"Formation of TC-NER Pre-Incision Complex";"Transcription of the HIV genome";"Gap-filling DNA repair synthesis and ligation in TC-NER";"RNA Polymerase II Pre-transcription Events";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Polymerase II Promoter Escape";"RNA Polymerase I Transcription Termination";"RNA Polymerase II Transcription Elongation";"RNA Polymerase II HIV Promoter Escape";"Dual incision in TC-NER";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Tat-mediated elongation of the HIV-1 transcript";"Cytosolic iron-sulfur cluster assembly";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"HIV Transcription Initiation";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"RNA Polymerase II Transcription Initiation";"Formation of the HIV-1 Early Elongation Complex";"Formation of Incision Complex in GG-NER";"RNA Polymerase I Transcription Initiation";"Formation of the Early Elongation Complex";"TP53 Regulates Transcription of DNA Repair Genes";"Formation of RNA Pol II elongation complex";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"mRNA Capping";"Dual Incision in GG-NER";"NoRC negatively regulates rRNA expression";"RNA Pol II CTD phosphorylation and interaction with CE"
Medex_00093838-RA	2	Reactome: R-HSA-9033241;Reactome: R-HSA-8866654	"Peroxisomal protein import";"E3 ubiquitin ligases ubiquitinate target proteins"
Medex_00048131-RA	1	Reactome: R-HSA-1799339	"SRP-dependent cotranslational protein targeting to membrane"
Medex_00080781-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Medex_00006911-RA	1	Reactome: R-HSA-5250924	"B-WICH complex positively regulates rRNA expression"
Medex_00035279-RA	42	Reactome: R-HSA-427359;Reactome: R-HSA-5334118;Reactome: R-HSA-9609690;Reactome: R-HSA-9610379;Reactome: R-HSA-1912408;Reactome: R-HSA-5693571;Reactome: R-HSA-977225;Reactome: R-HSA-110328;Reactome: R-HSA-2299718;Reactome: R-HSA-3214858;Reactome: R-HSA-3214841;Reactome: R-HSA-427389;Reactome: R-HSA-5578749;Reactome: R-HSA-2559582;Reactome: R-HSA-5617472;Reactome: R-HSA-2559586;Reactome: R-HSA-9018519;Reactome: R-HSA-212300;Reactome: R-HSA-5250924;Reactome: R-HSA-606279;Reactome: R-HSA-110331;Reactome: R-HSA-1221632;Reactome: R-HSA-2559580;Reactome: R-HSA-110329;Reactome: R-HSA-171306;Reactome: R-HSA-427413;Reactome: R-HSA-3214847;Reactome: R-HSA-201722;Reactome: R-HSA-4551638;Reactome: R-HSA-9616222;Reactome: R-HSA-912446;Reactome: R-HSA-8936459;Reactome: R-HSA-5625886;Reactome: R-HSA-3214842;Reactome: R-HSA-69473;Reactome: R-HSA-3214815;Reactome: R-HSA-110330;Reactome: R-HSA-5693565;Reactome: R-HSA-8939236;Reactome: R-HSA-5693607;Reactome: R-HSA-73728;Reactome: R-HSA-73772	"SIRT1 negatively regulates rRNA expression";"DNA methylation";"HCMV Early Events";"HCMV Late Events";"Pre-NOTCH Transcription and Translation";"Nonhomologous End-Joining (NHEJ)";"Amyloid fiber formation";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"Condensation of Prophase Chromosomes";"RMTs methylate histone arginines";"PKMTs methylate histone lysines";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"Transcriptional regulation by small RNAs";"Senescence-Associated Secretory Phenotype (SASP)";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"DNA Damage/Telomere Stress Induced Senescence";"Estrogen-dependent gene expression";"PRC2 methylates histones and DNA";"B-WICH complex positively regulates rRNA expression";"Deposition of new CENPA-containing nucleosomes at the centromere";"Cleavage of the damaged purine";"Meiotic synapsis";"Oxidative Stress Induced Senescence";"Cleavage of the damaged pyrimidine";"Packaging Of Telomere Ends";"NoRC negatively regulates rRNA expression";"HATs acetylate histones";"Formation of the beta-catenin:TCF transactivating complex";"SUMOylation of chromatin organization proteins";"Transcriptional regulation of granulopoiesis";"Meiotic recombination";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3";"HDMs demethylate histones";"G2/M DNA damage checkpoint";"HDACs deacetylate histones";"Recognition and association of DNA glycosylase with site containing an affected purine";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Processing of DNA double-strand break ends";"RNA Polymerase I Promoter Opening";"RNA Polymerase I Promoter Escape"
Medex_00061812-RA	1	KEGG: 00970+6.1.1.19	"Aminoacyl-tRNA biosynthesis"
Medex_00063092-RA	1	Reactome: R-HSA-1614635	"Sulfur amino acid metabolism"
Medex_00021030-RA	1	Reactome: R-HSA-611105	"Respiratory electron transport"
Medex_00014239-RA	14	Reactome: R-HSA-5696397;Reactome: R-HSA-110312;Reactome: R-HSA-5685942;Reactome: R-HSA-5656121;Reactome: R-HSA-6782210;Reactome: R-HSA-5656169;Reactome: R-HSA-69091;Reactome: R-HSA-110320;Reactome: R-HSA-5651801;Reactome: R-HSA-6782135;Reactome: R-HSA-110314;Reactome: R-HSA-5655862;Reactome: R-HSA-174411;Reactome: R-HSA-5696400	"Gap-filling DNA repair synthesis and ligation in GG-NER";"Translesion synthesis by REV1";"HDR through Homologous Recombination (HRR)";"Translesion synthesis by POLI";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Termination of translesion DNA synthesis";"Polymerase switching";"Translesion Synthesis by POLH";"PCNA-Dependent Long Patch Base Excision Repair";"Dual incision in TC-NER";"Recognition of DNA damage by PCNA-containing replication complex";"Translesion synthesis by POLK";"Polymerase switching on the C-strand of the telomere";"Dual Incision in GG-NER"
Medex_00033043-RA	6	MetaCyc: PWY-7782;MetaCyc: PWY-6733;MetaCyc: PWY-7656;KEGG: 00073+1.2.1.84;MetaCyc: PWY-5884;Reactome: R-HSA-9640463	"Plasmalogen biosynthesis";"Sporopollenin precursors biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax esters biosynthesis I";"Wax biosynthesis"
Medex_00037544-RA	22	Reactome: R-HSA-5358752;Reactome: R-HSA-196299;Reactome: R-HSA-5663220;Reactome: R-HSA-5358747;Reactome: R-HSA-5675221;Reactome: R-HSA-5339716;Reactome: R-HSA-2500257;Reactome: R-HSA-5467340;Reactome: R-HSA-5467337;Reactome: R-HSA-2467813;Reactome: R-HSA-68877;Reactome: R-HSA-9648025;Reactome: R-HSA-432142;Reactome: R-HSA-195253;Reactome: R-HSA-389513;Reactome: R-HSA-141444;Reactome: R-HSA-4641262;Reactome: R-HSA-5673000;Reactome: R-HSA-6811558;Reactome: R-HSA-5467348;Reactome: R-HSA-5358751;Reactome: R-HSA-5358749	"T41 mutants of beta-catenin aren't phosphorylated";"Beta-catenin phosphorylation cascade";"RHO GTPases Activate Formins";"S33 mutants of beta-catenin aren't phosphorylated";"Negative regulation of MAPK pathway";"Misspliced GSK3beta mutants stabilize beta-catenin";"Resolution of Sister Chromatid Cohesion";"AXIN missense mutants destabilize the destruction complex";"APC truncation mutants have impaired AXIN binding";"Separation of Sister Chromatids";"Mitotic Prometaphase";"EML4 and NUDC in mitotic spindle formation";"Platelet sensitization by LDL";"Degradation of beta-catenin by the destruction complex";"CTLA4 inhibitory signaling";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"RAF activation";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"Truncations of AMER1 destabilize the destruction complex";"S45 mutants of beta-catenin aren't phosphorylated";"S37 mutants of beta-catenin aren't phosphorylated"
Medex_00098033-RA	3	Reactome: R-HSA-1474151;KEGG: 00790+1.1.1.153;Reactome: R-HSA-203615	"Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation";"Folate biosynthesis";"eNOS activation"
Medex_00078651-RA	1	Reactome: R-HSA-432047	"Passive transport by Aquaporins"
Medex_00084231-RA	6	KEGG: 00511+3.2.1.23;KEGG: 00600+3.2.1.23;MetaCyc: PWY-6807;KEGG: 00604+3.2.1.23;KEGG: 00052+3.2.1.23;KEGG: 00531+3.2.1.23	"Other glycan degradation";"Sphingolipid metabolism";"Xyloglucan degradation II (exoglucanase)";"Glycosphingolipid biosynthesis - ganglio series";"Galactose metabolism";"Glycosaminoglycan degradation"
Medex_00053839-RA	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
Medex_00075183-RA	2	Reactome: R-HSA-6804115;Reactome: R-HSA-429947	"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Deadenylation of mRNA"
Medex_00092802-RA	18	KEGG: 00401+2.6.1.1;KEGG: 00400+2.6.1.1;KEGG: 00330+2.6.1.1;KEGG: 00960+2.6.1.1;KEGG: 00950+2.6.1.1;KEGG: 00250+2.6.1.1;KEGG: 00710+2.6.1.1;MetaCyc: PWY-7117;MetaCyc: PWY-6642;MetaCyc: PWY-6638;MetaCyc: PWY-7383;MetaCyc: PWY-7115;MetaCyc: PWY-5913;MetaCyc: PWY-6643;KEGG: 00350+2.6.1.1;KEGG: 00360+2.6.1.1;KEGG: 00220+2.6.1.1;KEGG: 00270+2.6.1.1	"Novobiocin biosynthesis";"Phenylalanine, tyrosine and tryptophan biosynthesis";"Arginine and proline metabolism";"Tropane, piperidine and pyridine alkaloid biosynthesis";"Isoquinoline alkaloid biosynthesis";"Alanine, aspartate and glutamate metabolism";"Carbon fixation in photosynthetic organisms";"C4 photosynthetic carbon assimilation cycle, PEPCK type";"(R)-cysteate degradation";"Sulfolactate degradation III";"Anaerobic energy metabolism (invertebrates, cytosol)";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"Partial TCA cycle (obligate autotrophs)";"Coenzyme M biosynthesis II";"Tyrosine metabolism";"Phenylalanine metabolism";"Arginine biosynthesis";"Cysteine and methionine metabolism"
Medex_00082599-RA	1	MetaCyc: PWY-6308	"L-cysteine biosynthesis II (tRNA-dependent)"
Medex_00054072-RA	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840	"Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation"
Medex_00074075-RA	3	MetaCyc: PWY-6100;KEGG: 00310+1.14.11.8;Reactome: R-HSA-71262	"L-carnitine biosynthesis";"Lysine degradation";"Carnitine synthesis"
Medex_00068489-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Medex_00068615-RA	1	Reactome: R-HSA-198933	"Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"
Medex_00016330-RA	6	Reactome: R-HSA-114508;MetaCyc: PWY-7039;KEGG: 00564+2.7.1.107;KEGG: 00561+2.7.1.107;KEGG: 04070+2.7.1.107;MetaCyc: PWY-7817	"Effects of PIP2 hydrolysis";"Phosphatidate metabolism, as a signaling molecule";"Glycerophospholipid metabolism";"Glycerolipid metabolism";"Phosphatidylinositol signaling system";"Type I lipoteichoic acid biosynthesis (S. aureus)"
Medex_00058737-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Medex_00009070-RA	7	KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1	"Human papillomavirus infection";"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Human cytomegalovirus infection";"Thermogenesis";"Relaxin signaling pathway"
Medex_00005658-RA	1	Reactome: R-HSA-216083	"Integrin cell surface interactions"
Medex_00005993-RA	1	Reactome: R-HSA-8949664	"Processing of SMDT1"
Medex_00050904-RA	6	KEGG: 00073+1.2.1.84;MetaCyc: PWY-6733;MetaCyc: PWY-7782;MetaCyc: PWY-7656;MetaCyc: PWY-5884;Reactome: R-HSA-9640463	"Cutin, suberine and wax biosynthesis";"Sporopollenin precursors biosynthesis";"Plasmalogen biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Wax esters biosynthesis I";"Wax biosynthesis"
Medex_00005933-RA	1	Reactome: R-HSA-9609523	"Insertion of tail-anchored proteins into the endoplasmic reticulum membrane"
Medex_00062819-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00021185-RA	20	Reactome: R-HSA-380972;Reactome: R-HSA-1632852;Reactome: R-HSA-165159;KEGG: 05170+2.7.11.1;Reactome: R-HSA-166208;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;Reactome: R-HSA-6804757;Reactome: R-HSA-8943724;KEGG: 04714+2.7.11.1;Reactome: R-HSA-3371571;Reactome: R-HSA-9639288;KEGG: 04150+2.7.11.1;Reactome: R-HSA-1257604;Reactome: R-HSA-5218920;Reactome: R-HSA-5628897;Reactome: R-HSA-389357;Reactome: R-HSA-5674400;KEGG: 05163+2.7.11.1;KEGG: 04151+2.7.11.1	"Energy dependent regulation of mTOR by LKB1-AMPK";"Macroautophagy";"mTOR signalling";"Human immunodeficiency virus 1 infection";"mTORC1-mediated signalling";"Human papillomavirus infection";"Relaxin signaling pathway";"Regulation of TP53 Degradation";"Regulation of PTEN gene transcription";"Thermogenesis";"HSF1-dependent transactivation";"Amino acids regulate mTORC1";"mTOR signaling pathway";"PIP3 activates AKT signaling";"VEGFR2 mediated vascular permeability";"TP53 Regulates Metabolic Genes";"CD28 dependent PI3K/Akt signaling";"Constitutive Signaling by AKT1 E17K in Cancer";"Human cytomegalovirus infection";"PI3K-Akt signaling pathway"
Medex_00046701-RA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
Medex_00022563-RA	2	Reactome: R-HSA-189451;KEGG: 00860+4.99.1.1	"Heme biosynthesis";"Porphyrin and chlorophyll metabolism"
Medex_00025598-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Medex_00070412-RA	12	Reactome: R-HSA-167290;Reactome: R-HSA-167152;Reactome: R-HSA-674695;Reactome: R-HSA-167287;Reactome: R-HSA-167243;Reactome: R-HSA-6796648;Reactome: R-HSA-167238;Reactome: R-HSA-75955;Reactome: R-HSA-112382;Reactome: R-HSA-167246;Reactome: R-HSA-6804756;Reactome: R-HSA-167200	"Pausing and recovery of HIV elongation";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Polymerase II Pre-transcription Events";"HIV elongation arrest and recovery";"Tat-mediated HIV elongation arrest and recovery";"TP53 Regulates Transcription of DNA Repair Genes";"Pausing and recovery of Tat-mediated HIV elongation";"RNA Polymerase II Transcription Elongation";"Formation of RNA Pol II elongation complex";"Tat-mediated elongation of the HIV-1 transcript";"Regulation of TP53 Activity through Phosphorylation";"Formation of HIV-1 elongation complex containing HIV-1 Tat"
Medex_00099732-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Medex_00042249-RA	1	Reactome: R-HSA-203754	"NOSIP mediated eNOS trafficking"
Medex_00021327-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00049356-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00013941-RA	8	Reactome: R-HSA-2559580;Reactome: R-HSA-212300;Reactome: R-HSA-5617472;Reactome: R-HSA-9609690;Reactome: R-HSA-4551638;Reactome: R-HSA-8953750;Reactome: R-HSA-3214841;Reactome: R-HSA-8943724	"Oxidative Stress Induced Senescence";"PRC2 methylates histones and DNA";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"HCMV Early Events";"SUMOylation of chromatin organization proteins";"Transcriptional Regulation by E2F6";"PKMTs methylate histone lysines";"Regulation of PTEN gene transcription"
Medex_00033727-RA	1	Reactome: R-HSA-4615885	"SUMOylation of DNA replication proteins"
Medex_00068578-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00080490-RA	2	Reactome: R-HSA-204005;Reactome: R-HSA-8876198	"COPII-mediated vesicle transport";"RAB GEFs exchange GTP for GDP on RABs"
Medex_00059009-RA	1	Reactome: R-HSA-5576886	"Phase 4 - resting membrane potential"
Medex_00070195-RA	6	Reactome: R-HSA-4086398;Reactome: R-HSA-4641265;Reactome: R-HSA-3769402;Reactome: R-HSA-201722;Reactome: R-HSA-4411364;Reactome: R-HSA-8951430	"Ca2+ pathway";"Repression of WNT target genes";"Deactivation of the beta-catenin transactivating complex";"Formation of the beta-catenin:TCF transactivating complex";"Binding of TCF/LEF:CTNNB1 to target gene promoters";"RUNX3 regulates WNT signaling"
Medex_00015863-RA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
Medex_00054992-RA	3	Reactome: R-HSA-193648;Reactome: R-HSA-416482;Reactome: R-HSA-194840	"NRAGE signals death through JNK";"G alpha (12/13) signalling events";"Rho GTPase cycle"
Medex_00059139-RA	5	Reactome: R-HSA-2395516;Reactome: R-HSA-1362409;Reactome: R-HSA-5579026;Reactome: R-HSA-196108;Reactome: R-HSA-211976	"Electron transport from NADPH to Ferredoxin";"Mitochondrial iron-sulfur cluster biogenesis";"Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)";"Pregnenolone biosynthesis";"Endogenous sterols"
Medex_00078091-RA	6	KEGG: 00073+1.2.1.84;MetaCyc: PWY-7656;MetaCyc: PWY-7782;MetaCyc: PWY-6733;MetaCyc: PWY-5884;Reactome: R-HSA-9640463	"Cutin, suberine and wax biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Plasmalogen biosynthesis";"Sporopollenin precursors biosynthesis";"Wax esters biosynthesis I";"Wax biosynthesis"
Medex_00022887-RA	1	Reactome: R-HSA-1632852	"Macroautophagy"
Medex_00045429-RA	6	MetaCyc: PWY-7782;MetaCyc: PWY-6733;MetaCyc: PWY-7656;KEGG: 00073+1.2.1.84;MetaCyc: PWY-5884;Reactome: R-HSA-9640463	"Plasmalogen biosynthesis";"Sporopollenin precursors biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax esters biosynthesis I";"Wax biosynthesis"
Medex_00093578-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Medex_00052455-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Medex_00081704-RA	1	Reactome: R-HSA-5632928	"Defective Mismatch Repair Associated With MSH2"
Medex_00008748-RA	6	Reactome: R-HSA-429958;Reactome: R-HSA-380994;Reactome: R-HSA-450604;Reactome: R-HSA-450513;Reactome: R-HSA-450385;Reactome: R-HSA-6791226	"mRNA decay by 3' to 5' exoribonuclease";"ATF4 activates genes in response to endoplasmic reticulum stress";"KSRP (KHSRP) binds and destabilizes mRNA";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"Major pathway of rRNA processing in the nucleolus and cytosol"
Medex_00067914-RA	3	MetaCyc: PWY-6807;KEGG: 00511+3.2.1.51;Reactome: R-HSA-6798695	"Xyloglucan degradation II (exoglucanase)";"Other glycan degradation";"Neutrophil degranulation"
Medex_00078736-RA	16	Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-72695;Reactome: R-HSA-156902;Reactome: R-HSA-72649;Reactome: R-HSA-192823;Reactome: R-HSA-2408557;Reactome: R-HSA-72689;Reactome: R-HSA-9633012;Reactome: R-HSA-1799339;Reactome: R-HSA-975957;Reactome: R-HSA-6791226;Reactome: R-HSA-72702;Reactome: R-HSA-72764;Reactome: R-HSA-975956;Reactome: R-HSA-72706	"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Formation of the ternary complex, and subsequently, the 43S complex";"Peptide chain elongation";"Translation initiation complex formation";"Viral mRNA Translation";"Selenocysteine synthesis";"Formation of a pool of free 40S subunits";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"Ribosomal scanning and start codon recognition";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit"
Medex_00072328-RA	2	Reactome: R-HSA-181429;Reactome: R-HSA-212676	"Serotonin Neurotransmitter Release Cycle";"Dopamine Neurotransmitter Release Cycle"
Medex_00084628-RA	1	MetaCyc: PWY-6829	"Trna methylation (yeast)"
Medex_00011494-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00012339-RA	3	Reactome: R-HSA-936837;Reactome: R-HSA-5578775;Reactome: R-HSA-418359	"Ion transport by P-type ATPases";"Ion homeostasis";"Reduction of cytosolic Ca++ levels"
Medex_00096819-RA	1	Reactome: R-HSA-69231	"Cyclin D associated events in G1"
Medex_00082444-RA	13	Reactome: R-HSA-72689;Reactome: R-HSA-72764;Reactome: R-HSA-975956;Reactome: R-HSA-72706;Reactome: R-HSA-6791226;Reactome: R-HSA-2408557;Reactome: R-HSA-192823;Reactome: R-HSA-975957;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-9633012;Reactome: R-HSA-156902;Reactome: R-HSA-1799339	"Formation of a pool of free 40S subunits";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Major pathway of rRNA processing in the nucleolus and cytosol";"Selenocysteine synthesis";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Peptide chain elongation";"SRP-dependent cotranslational protein targeting to membrane"
Medex_00045038-RA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
Medex_00027801-RA	10	Reactome: R-HSA-445144;Reactome: R-HSA-6804756;Reactome: R-HSA-6798695;Reactome: R-HSA-8948751;Reactome: R-HSA-2514853;Reactome: R-HSA-201688;Reactome: R-HSA-8939243;Reactome: R-HSA-6814122;Reactome: R-HSA-1483191;Reactome: R-HSA-8934903	"Signal transduction by L1";"Regulation of TP53 Activity through Phosphorylation";"Neutrophil degranulation";"Regulation of PTEN stability and activity";"Condensation of Prometaphase Chromosomes";"WNT mediated activation of DVL";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"Synthesis of PC";"Receptor Mediated Mitophagy"
Medex_00065320-RA	1	Reactome: R-HSA-110320	"Translesion Synthesis by POLH"
Medex_00067861-RA	1	Reactome: R-HSA-5223345	"Miscellaneous transport and binding events"
Medex_00034149-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Medex_00014145-RA	5	Reactome: R-HSA-389661;KEGG: 00640+1.2.4.4;KEGG: 00280+1.2.4.4;MetaCyc: PWY-5046;Reactome: R-HSA-70895	"Glyoxylate metabolism and glycine degradation";"Propanoate metabolism";"Valine, leucine and isoleucine degradation";"2-oxoisovalerate decarboxylation to isobutanoyl-CoA";"Branched-chain amino acid catabolism"
Medex_00038170-RA	15	KEGG: 00230+2.7.1.40;MetaCyc: PWY-2221;MetaCyc: PWY-6886;Reactome: R-HSA-70171;MetaCyc: PWY-1042;MetaCyc: PWY-5723;MetaCyc: PWY-6142;MetaCyc: PWY-6901;KEGG: 00620+2.7.1.40;MetaCyc: PWY-7003;MetaCyc: PWY-8004;MetaCyc: PWY-7218;MetaCyc: PWY-5484;KEGG: 00010+2.7.1.40;MetaCyc: PWY-7383	"Purine metabolism";"Entner-Doudoroff pathway III (semi-phosphorylative)";"1-butanol autotrophic biosynthesis (engineered)";"Glycolysis";"Glycolysis IV (plant cytosol)";"Rubisco shunt";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Superpathway of glucose and xylose degradation";"Pyruvate metabolism";"Glycerol degradation to butanol";"Entner-Doudoroff pathway I";"Photosynthetic 3-hydroxybutanoate biosynthesis (engineered)";"Glycolysis II (from fructose 6-phosphate)";"Glycolysis / Gluconeogenesis";"Anaerobic energy metabolism (invertebrates, cytosol)"
Medex_00012349-RA	1	Reactome: R-HSA-110362	"POLB-Dependent Long Patch Base Excision Repair"
Medex_00090350-RA	3	MetaCyc: PWY-7420;KEGG: 00561+3.1.1.23;Reactome: R-HSA-426048	"Monoacylglycerol metabolism (yeast)";"Glycerolipid metabolism";"Arachidonate production from DAG"
Medex_00077517-RA	3	MetaCyc: PWY-6348;KEGG: 00730+3.1.3.2;KEGG: 00740+3.1.3.2	"Phosphate acquisition";"Thiamine metabolism";"Riboflavin metabolism"
Medex_00000377-RA	4	Reactome: R-HSA-8951664;Reactome: R-HSA-5696394;Reactome: R-HSA-8856825;Reactome: R-HSA-6781823	"Neddylation";"DNA Damage Recognition in GG-NER";"Cargo recognition for clathrin-mediated endocytosis";"Formation of TC-NER Pre-Incision Complex"
Medex_00016719-RA	2	Reactome: R-HSA-5628897;Reactome: R-HSA-611105	"TP53 Regulates Metabolic Genes";"Respiratory electron transport"
Medex_00009598-RA	5	Reactome: R-HSA-111447;Reactome: R-HSA-5625740;Reactome: R-HSA-1445148;Reactome: R-HSA-5628897;Reactome: R-HSA-75035	"Activation of BAD and translocation to mitochondria";"RHO GTPases activate PKNs";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"TP53 Regulates Metabolic Genes";"Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex"
Medex_00055442-RA	5	MetaCyc: PWY-6855;MetaCyc: PWY-6906;KEGG: 00520+3.5.99.6;Reactome: R-HSA-70171;MetaCyc: PWY-5514	"Chitin degradation I (archaea)";"Chitin derivatives degradation";"Amino sugar and nucleotide sugar metabolism";"Glycolysis";"UDP-N-acetyl-D-galactosamine biosynthesis II"
Medex_00012424-RA	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
Medex_00057055-RA	6	MetaCyc: PWY-7511;Reactome: R-HSA-6782210;Reactome: R-HSA-6782135;Reactome: R-HSA-6781823;Reactome: R-HSA-6781827;Reactome: R-HSA-72163	"Protein ubiquitination";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Dual incision in TC-NER";"Formation of TC-NER Pre-Incision Complex";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"mRNA Splicing - Major Pathway"
Medex_00029427-RA	2	Reactome: R-HSA-5689603;Reactome: R-HSA-5689880	"UCH proteinases";"Ub-specific processing proteases"
Medex_00017776-RA	9	Reactome: R-HSA-167162;Reactome: R-HSA-76042;Reactome: R-HSA-73779;Reactome: R-HSA-6804756;Reactome: R-HSA-75953;Reactome: R-HSA-167161;Reactome: R-HSA-167172;Reactome: R-HSA-674695;Reactome: R-HSA-73776	"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Regulation of TP53 Activity through Phosphorylation";"RNA Polymerase II Transcription Initiation";"HIV Transcription Initiation";"Transcription of the HIV genome";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Promoter Escape"
Medex_00014149-RA	4	Reactome: R-HSA-936837;Reactome: R-HSA-5578775;Reactome: R-HSA-418359;Reactome: R-HSA-1912420	"Ion transport by P-type ATPases";"Ion homeostasis";"Reduction of cytosolic Ca++ levels";"Pre-NOTCH Processing in Golgi"
Medex_00009670-RA	3	KEGG: 00511+3.2.1.51;MetaCyc: PWY-6807;Reactome: R-HSA-6798695	"Other glycan degradation";"Xyloglucan degradation II (exoglucanase)";"Neutrophil degranulation"
Medex_00048638-RA	3	KEGG: 00230+4.6.1.2;Reactome: R-HSA-392154;Reactome: R-HSA-445355	"Purine metabolism";"Nitric oxide stimulates guanylate cyclase";"Smooth Muscle Contraction"
Medex_00087692-RA	3	Reactome: R-HSA-194840;Reactome: R-HSA-416482;Reactome: R-HSA-193648	"Rho GTPase cycle";"G alpha (12/13) signalling events";"NRAGE signals death through JNK"
Medex_00080725-RA	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5419276;Reactome: R-HSA-5389840	"Mitochondrial translation initiation";"Mitochondrial translation termination";"Mitochondrial translation elongation"
Medex_00055213-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Medex_00020193-RA	1	Reactome: R-HSA-8849932	"Synaptic adhesion-like molecules"
Medex_00022504-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00001742-RA	6	MetaCyc: PWY-7782;MetaCyc: PWY-6733;MetaCyc: PWY-7656;KEGG: 00073+1.2.1.84;MetaCyc: PWY-5884;Reactome: R-HSA-9640463	"Plasmalogen biosynthesis";"Sporopollenin precursors biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax esters biosynthesis I";"Wax biosynthesis"
Medex_00014683-RA	1	Reactome: R-HSA-5601884	"PIWI-interacting RNA (piRNA) biogenesis"
Medex_00027691-RA	1	Reactome: R-HSA-211981	"Xenobiotics"
Medex_00057484-RA	2	KEGG: 00627+3.6.1.7;KEGG: 00620+3.6.1.7	"Aminobenzoate degradation";"Pyruvate metabolism"
Medex_00005140-RA	6	Reactome: R-HSA-6804759;Reactome: R-HSA-6803211;Reactome: R-HSA-6803205;Reactome: R-HSA-6803207;Reactome: R-HSA-139915;Reactome: R-HSA-6803204	"Regulation of TP53 Activity through Association with Co-factors";"TP53 Regulates Transcription of Death Receptors and Ligands";"TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain";"TP53 Regulates Transcription of Caspase Activators and Caspases";"Activation of PUMA and translocation to mitochondria";"TP53 Regulates Transcription of Genes Involved in Cytochrome C Release"
Medex_00004062-RA	2	MetaCyc: PWY-6788;KEGG: 00500+3.2.1.4	"Cellulose degradation II (fungi)";"Starch and sucrose metabolism"
Medex_00021908-RA	1	Reactome: R-HSA-72203	"Processing of Capped Intron-Containing Pre-mRNA"
Medex_00015581-RA	6	Reactome: R-HSA-68962;Reactome: R-HSA-176974;Reactome: R-HSA-176187;Reactome: R-HSA-69052;Reactome: R-HSA-68949;Reactome: R-HSA-68867	"Activation of the pre-replicative complex";"Unwinding of DNA";"Activation of ATR in response to replication stress";"Switching of origins to a post-replicative state";"Orc1 removal from chromatin";"Assembly of the pre-replicative complex"
Medex_00074179-RA	12	Reactome: R-HSA-210744;Reactome: R-HSA-350054;Reactome: R-HSA-5250924;Reactome: R-HSA-8941856;Reactome: R-HSA-73762;Reactome: R-HSA-2644606;Reactome: R-HSA-2122947;Reactome: R-HSA-9013695;Reactome: R-HSA-3214847;Reactome: R-HSA-9013508;Reactome: R-HSA-2894862;Reactome: R-HSA-1912408	"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"Notch-HLH transcription pathway";"B-WICH complex positively regulates rRNA expression";"RUNX3 regulates NOTCH signaling";"RNA Polymerase I Transcription Initiation";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH1 Intracellular Domain Regulates Transcription";"NOTCH4 Intracellular Domain Regulates Transcription";"HATs acetylate histones";"NOTCH3 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Pre-NOTCH Transcription and Translation"
Medex_00071818-RA	1	KEGG: 00760+2.3.1.286	"Nicotinate and nicotinamide metabolism"
Medex_00062881-RA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
Medex_00050791-RA	5	Reactome: R-HSA-917977;Reactome: R-HSA-983712;Reactome: R-HSA-77387;Reactome: R-HSA-9639288;Reactome: R-HSA-1222556	"Transferrin endocytosis and recycling";"Ion channel transport";"Insulin receptor recycling";"Amino acids regulate mTORC1";"ROS and RNS production in phagocytes"
Medex_00030057-RA	5	MetaCyc: PWY-7176;MetaCyc: PWY-7185;KEGG: 00240+6.3.4.2;MetaCyc: PWY-7177;Reactome: R-HSA-499943	"UTP and CTP de novo biosynthesis";"UTP and CTP dephosphorylation I";"Pyrimidine metabolism";"UTP and CTP dephosphorylation II";"Interconversion of nucleotide di- and triphosphates"
Medex_00047350-RA	1	Reactome: R-HSA-74217	"Purine salvage"
Medex_00068580-RA	11	Reactome: R-HSA-2029482;Reactome: R-HSA-525793;Reactome: R-HSA-8940973;Reactome: R-HSA-5693565;KEGG: 04660+2.7.10.2;Reactome: R-HSA-5685938;Reactome: R-HSA-428890;Reactome: R-HSA-8939236;Reactome: R-HSA-983231;Reactome: R-HSA-5663213;Reactome: R-HSA-69231	"Regulation of actin dynamics for phagocytic cup formation";"Myogenesis";"RUNX2 regulates osteoblast differentiation";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"T cell receptor signaling pathway";"HDR through Single Strand Annealing (SSA)";"Role of ABL in ROBO-SLIT signaling";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Factors involved in megakaryocyte development and platelet production";"RHO GTPases Activate WASPs and WAVEs";"Cyclin D associated events in G1"
Medex_00053304-RA	4	Reactome: R-HSA-917977;Reactome: R-HSA-77387;Reactome: R-HSA-983712;Reactome: R-HSA-1222556	"Transferrin endocytosis and recycling";"Insulin receptor recycling";"Ion channel transport";"ROS and RNS production in phagocytes"
Medex_00009730-RA	1	Reactome: R-HSA-8856825	"Cargo recognition for clathrin-mediated endocytosis"
Medex_00017878-RA	1	Reactome: R-HSA-8951664	"Neddylation"
Medex_00054536-RA	1	Reactome: R-HSA-6798163	"Choline catabolism"
Medex_00009817-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00028186-RA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Medex_00010622-RA	1	Reactome: R-HSA-5223345	"Miscellaneous transport and binding events"
Medex_00024650-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Medex_00057699-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Medex_00015908-RA	1	Reactome: R-HSA-6811434	"COPI-dependent Golgi-to-ER retrograde traffic"
Medex_00047424-RA	2	Reactome: R-HSA-383280;Reactome: R-HSA-983231	"Nuclear Receptor transcription pathway";"Factors involved in megakaryocyte development and platelet production"
Medex_00014264-RA	2	KEGG: 04070+2.7.11.13;Reactome: R-HSA-1660661	"Phosphatidylinositol signaling system";"Sphingolipid de novo biosynthesis"
Medex_00052781-RA	5	Reactome: R-HSA-73856;Reactome: R-HSA-72187;Reactome: R-HSA-72163;Reactome: R-HSA-77595;Reactome: R-HSA-159231	"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing";"mRNA Splicing - Major Pathway";"Processing of Intronless Pre-mRNAs";"Transport of Mature mRNA Derived from an Intronless Transcript"
Medex_00089097-RA	2	Reactome: R-HSA-8866423;Reactome: R-HSA-8963888	"VLDL assembly";"Chylomicron assembly"
Medex_00091965-RA	3	Reactome: R-HSA-2022854;Reactome: R-HSA-5173105;Reactome: R-HSA-5083627	"Keratan sulfate biosynthesis";"O-linked glycosylation";"Defective LARGE causes MDDGA6 and MDDGB6"
Medex_00078062-RA	13	Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-9633012;Reactome: R-HSA-156902;Reactome: R-HSA-1799339;Reactome: R-HSA-192823;Reactome: R-HSA-975957;Reactome: R-HSA-6791226;Reactome: R-HSA-2408557;Reactome: R-HSA-72689;Reactome: R-HSA-72764;Reactome: R-HSA-975956;Reactome: R-HSA-72706	"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Peptide chain elongation";"SRP-dependent cotranslational protein targeting to membrane";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"Selenocysteine synthesis";"Formation of a pool of free 40S subunits";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit"
Medex_00073419-RA	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
Medex_00068180-RA	7	KEGG: 00500+2.4.1.25;MetaCyc: PWY-5941;MetaCyc: PWY-6737;Reactome: R-HSA-70221;MetaCyc: PWY-7238;Reactome: R-HSA-6798695;MetaCyc: PWY-6724	"Starch and sucrose metabolism";"Glycogen degradation II";"Starch degradation V";"Glycogen breakdown (glycogenolysis)";"Sucrose biosynthesis II";"Neutrophil degranulation";"Starch degradation II"
Medex_00082493-RA	3	MetaCyc: PWY-7999;Reactome: R-HSA-159740;KEGG: 00130+4.1.1.90	"Vitamin K-epoxide cycle";"Gamma-carboxylation of protein precursors";"Ubiquinone and other terpenoid-quinone biosynthesis"
Medex_00016433-RA	5	Reactome: R-HSA-532668;Reactome: R-HSA-4793954;KEGG: 00510+3.2.1.106;MetaCyc: PWY-7919;MetaCyc: PWY-7918	"N-glycan trimming in the ER and Calnexin/Calreticulin cycle";"Defective MOGS causes MOGS-CDG (CDG-2b)";"N-Glycan biosynthesis";"Protein N-glycosylation processing phase (plants and animals)";"Protein N-glycosylation processing phase (yeast)"
Medex_00033957-RA	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
Medex_00022120-RA	8	KEGG: 00030+2.2.1.2;Reactome: R-HSA-163754;MetaCyc: PWY-1861;Reactome: R-HSA-71336;Reactome: R-HSA-6791462;Reactome: R-HSA-8950505;MetaCyc: PWY-5723;Reactome: R-HSA-6791055	"Pentose phosphate pathway";"Insulin effects increased synthesis of Xylulose-5-Phosphate";"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"Pentose phosphate pathway";"TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P";"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation";"Rubisco shunt";"TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P"
Medex_00078926-RA	1	KEGG: 00480+3.4.11.2	"Glutathione metabolism"
Medex_00035348-RA	2	Reactome: R-HSA-975577;Reactome: R-HSA-2022854	"N-Glycan antennae elongation";"Keratan sulfate biosynthesis"
Medex_00100307-RA	4	Reactome: R-HSA-112311;Reactome: R-HSA-1483191;Reactome: R-HSA-422085;KEGG: 00564+3.1.1.7	"Neurotransmitter clearance";"Synthesis of PC";"Synthesis, secretion, and deacylation of Ghrelin";"Glycerophospholipid metabolism"
Medex_00002442-RA	4	Reactome: R-HSA-936440;Reactome: R-HSA-8934903;Reactome: R-HSA-1632852;Reactome: R-HSA-5205685	"Negative regulators of DDX58/IFIH1 signaling";"Receptor Mediated Mitophagy";"Macroautophagy";"Pink/Parkin Mediated Mitophagy"
Medex_00033004-RA	16	Reactome: R-HSA-8951664;Reactome: R-HSA-1234176;Reactome: R-HSA-6796648;Reactome: R-HSA-167238;Reactome: R-HSA-112382;Reactome: R-HSA-9010553;Reactome: R-HSA-167152;Reactome: R-HSA-674695;Reactome: R-HSA-167243;Reactome: R-HSA-167287;Reactome: R-HSA-167290;Reactome: R-HSA-180585;Reactome: R-HSA-167246;Reactome: R-HSA-167200;Reactome: R-HSA-75955;Reactome: R-HSA-983168	"Neddylation";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"TP53 Regulates Transcription of DNA Repair Genes";"Pausing and recovery of Tat-mediated HIV elongation";"Formation of RNA Pol II elongation complex";"Regulation of expression of SLITs and ROBOs";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Polymerase II Pre-transcription Events";"Tat-mediated HIV elongation arrest and recovery";"HIV elongation arrest and recovery";"Pausing and recovery of HIV elongation";"Vif-mediated degradation of APOBEC3G";"Tat-mediated elongation of the HIV-1 transcript";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Polymerase II Transcription Elongation";"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00053572-RA	2	Reactome: R-HSA-400253;Reactome: R-HSA-2151201	"Circadian Clock";"Transcriptional activation of mitochondrial biogenesis"
Medex_00094000-RA	6	Reactome: R-HSA-1650814;Reactome: R-HSA-1442490;Reactome: R-HSA-8874081;Reactome: R-HSA-8948216;Reactome: R-HSA-3000171;Reactome: R-HSA-2022090	"Collagen biosynthesis and modifying enzymes";"Collagen degradation";"MET activates PTK2 signaling";"Collagen chain trimerization";"Non-integrin membrane-ECM interactions";"Assembly of collagen fibrils and other multimeric structures"
Medex_00068673-RA	4	Reactome: R-HSA-446388;Reactome: R-HSA-3000170;Reactome: R-HSA-114608;Reactome: R-HSA-373753	"Regulation of cytoskeletal remodeling and cell spreading by IPP complex components";"Syndecan interactions";"Platelet degranulation";"Nephrin family interactions"
Medex_00088928-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Medex_00011414-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Medex_00001761-RA	1	Reactome: R-HSA-69273	"Cyclin A/B1/B2 associated events during G2/M transition"
Medex_00004113-RA	3	Reactome: R-HSA-2029482;Reactome: R-HSA-4420097;Reactome: R-HSA-5663213	"Regulation of actin dynamics for phagocytic cup formation";"VEGFA-VEGFR2 Pathway";"RHO GTPases Activate WASPs and WAVEs"
Medex_00030899-RA	6	Reactome: R-HSA-6798695;KEGG: 00630+1.11.1.6;Reactome: R-HSA-9033241;KEGG: 00380+1.11.1.6;Reactome: R-HSA-9615017;Reactome: R-HSA-3299685	"Neutrophil degranulation";"Glyoxylate and dicarboxylate metabolism";"Peroxisomal protein import";"Tryptophan metabolism";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"Detoxification of Reactive Oxygen Species"
Medex_00044025-RA	3	MetaCyc: PWY-6348;KEGG: 00740+3.1.3.2;KEGG: 00730+3.1.3.2	"Phosphate acquisition";"Riboflavin metabolism";"Thiamine metabolism"
Medex_00074750-RA	12	Reactome: R-HSA-1912408;Reactome: R-HSA-3214847;Reactome: R-HSA-2894862;Reactome: R-HSA-9013508;Reactome: R-HSA-2644606;Reactome: R-HSA-2122947;Reactome: R-HSA-9013695;Reactome: R-HSA-210744;Reactome: R-HSA-350054;Reactome: R-HSA-5250924;Reactome: R-HSA-8941856;Reactome: R-HSA-73762	"Pre-NOTCH Transcription and Translation";"HATs acetylate histones";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"NOTCH3 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH1 Intracellular Domain Regulates Transcription";"NOTCH4 Intracellular Domain Regulates Transcription";"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"Notch-HLH transcription pathway";"B-WICH complex positively regulates rRNA expression";"RUNX3 regulates NOTCH signaling";"RNA Polymerase I Transcription Initiation"
Medex_00080293-RA	4	KEGG: 00230+6.3.5.2;KEGG: 00983+6.3.5.2;MetaCyc: PWY-7221;Reactome: R-HSA-73817	"Purine metabolism";"Drug metabolism - other enzymes";"Guanosine ribonucleotides de novo biosynthesis";"Purine ribonucleoside monophosphate biosynthesis"
Medex_00021925-RA	3	Reactome: R-HSA-6787450;Reactome: R-HSA-6785470;Reactome: R-HSA-8868766	"tRNA modification in the mitochondrion";"tRNA processing in the mitochondrion";"rRNA processing in the mitochondrion"
Medex_00050849-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00023219-RA	3	Reactome: R-HSA-1989781;Reactome: R-HSA-381340;Reactome: R-HSA-212436	"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation";"Generic Transcription Pathway"
Medex_00021049-RA	10	KEGG: 04151+2.7.11.1;Reactome: R-HSA-5689880;Reactome: R-HSA-3214847;Reactome: R-HSA-201722;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1	"PI3K-Akt signaling pathway";"Ub-specific processing proteases";"HATs acetylate histones";"Formation of the beta-catenin:TCF transactivating complex";"Human cytomegalovirus infection";"Relaxin signaling pathway";"mTOR signaling pathway";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Thermogenesis"
Medex_00012255-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Medex_00008559-RA	2	Reactome: R-HSA-3295583;Reactome: R-HSA-418890	"TRP channels";"Role of second messengers in netrin-1 signaling"
Medex_00075116-RA	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
Medex_00052444-RA	1	Reactome: R-HSA-216083	"Integrin cell surface interactions"
Medex_00051839-RA	4	Reactome: R-HSA-983712;Reactome: R-HSA-77387;Reactome: R-HSA-1222556;Reactome: R-HSA-917977	"Ion channel transport";"Insulin receptor recycling";"ROS and RNS production in phagocytes";"Transferrin endocytosis and recycling"
Medex_00004057-RA	2	Reactome: R-HSA-1483152;Reactome: R-HSA-1483115	"Hydrolysis of LPE";"Hydrolysis of LPC"
Medex_00073569-RA	4	Reactome: R-HSA-186763;Reactome: R-HSA-8875555;Reactome: R-HSA-8875656;Reactome: R-HSA-912631	"Downstream signal transduction";"MET activates RAP1 and RAC1";"MET receptor recycling";"Regulation of signaling by CBL"
Medex_00052041-RA	13	Reactome: R-HSA-192823;Reactome: R-HSA-975957;Reactome: R-HSA-156902;Reactome: R-HSA-9633012;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-1799339;Reactome: R-HSA-72689;Reactome: R-HSA-72764;Reactome: R-HSA-72706;Reactome: R-HSA-975956;Reactome: R-HSA-6791226;Reactome: R-HSA-2408557	"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Peptide chain elongation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"SRP-dependent cotranslational protein targeting to membrane";"Formation of a pool of free 40S subunits";"Eukaryotic Translation Termination";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"Selenocysteine synthesis"
Medex_00058264-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Medex_00091385-RA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
Medex_00035545-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00021991-RA	1	MetaCyc: PWY-7799	"Arg/N-end rule pathway (eukaryotic)"
Medex_00049087-RA	3	Reactome: R-HSA-674695;Reactome: R-HSA-75955;Reactome: R-HSA-112382	"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Elongation";"Formation of RNA Pol II elongation complex"
Medex_00044583-RA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Medex_00042784-RA	10	Reactome: R-HSA-8856828;Reactome: R-HSA-190873;Reactome: R-HSA-203641;Reactome: R-HSA-2132295;Reactome: R-HSA-432720;Reactome: R-HSA-437239;Reactome: R-HSA-196025;Reactome: R-HSA-177504;Reactome: R-HSA-432722;Reactome: R-HSA-166016	"Clathrin-mediated endocytosis";"Gap junction degradation";"NOSTRIN mediated eNOS trafficking";"MHC class II antigen presentation";"Lysosome Vesicle Biogenesis";"Recycling pathway of L1";"Formation of annular gap junctions";"Retrograde neurotrophin signalling";"Golgi Associated Vesicle Biogenesis";"Toll Like Receptor 4 (TLR4) Cascade"
Medex_00055933-RA	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
Medex_00073604-RA	1	KEGG: 00010+5.1.3.15	"Glycolysis / Gluconeogenesis"
Medex_00003634-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00009820-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00008995-RA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
Medex_00022896-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Medex_00026503-RA	1	Reactome: R-HSA-6811438	"Intra-Golgi traffic"
Medex_00090355-RA	4	MetaCyc: PWY-6855;MetaCyc: PWY-7822;MetaCyc: PWY-6902;KEGG: 00520+3.2.1.14	"Chitin degradation I (archaea)";"Chitin degradation III (Serratia)";"Chitin degradation II (Vibrio)";"Amino sugar and nucleotide sugar metabolism"
Medex_00012262-RA	2	Reactome: R-HSA-380320;Reactome: R-HSA-380270	"Recruitment of NuMA to mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes"
Medex_00005371-RA	5	Reactome: R-HSA-75105;Reactome: R-HSA-9029558;Reactome: R-HSA-199220;Reactome: R-HSA-163765;Reactome: R-HSA-2426168	"Fatty acyl-CoA biosynthesis";"NR1H2 & NR1H3 regulate gene expression linked to lipogenesis";"Vitamin B5 (pantothenate) metabolism";"ChREBP activates metabolic gene expression";"Activation of gene expression by SREBF (SREBP)"
Medex_00015345-RA	4	Reactome: R-HSA-499943;MetaCyc: PWY-7219;KEGG: 00230+2.7.4.3;KEGG: 00730+2.7.4.3	"Interconversion of nucleotide di- and triphosphates";"Adenosine ribonucleotides de novo biosynthesis";"Purine metabolism";"Thiamine metabolism"
Medex_00061982-RA	2	MetaCyc: PWY-6281;KEGG: 00450+2.7.9.3	"L-selenocysteine biosynthesis II (archaea and eukaryotes)";"Selenocompound metabolism"
Medex_00093234-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00006299-RA	29	Reactome: R-HSA-77075;Reactome: R-HSA-427413;Reactome: R-HSA-6796648;Reactome: R-HSA-73779;Reactome: R-HSA-5696400;Reactome: R-HSA-72086;Reactome: R-HSA-112382;Reactome: R-HSA-73762;Reactome: R-HSA-113418;Reactome: R-HSA-167158;Reactome: R-HSA-5696395;Reactome: R-HSA-75953;Reactome: R-HSA-6781827;Reactome: R-HSA-167161;Reactome: R-HSA-167246;Reactome: R-HSA-167160;Reactome: R-HSA-167200;Reactome: R-HSA-6782135;Reactome: R-HSA-76042;Reactome: R-HSA-167162;Reactome: R-HSA-75955;Reactome: R-HSA-73776;Reactome: R-HSA-167152;Reactome: R-HSA-674695;Reactome: R-HSA-73863;Reactome: R-HSA-167172;Reactome: R-HSA-73772;Reactome: R-HSA-6781823;Reactome: R-HSA-6782210	"RNA Pol II CTD phosphorylation and interaction with CE";"NoRC negatively regulates rRNA expression";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Dual Incision in GG-NER";"mRNA Capping";"Formation of RNA Pol II elongation complex";"RNA Polymerase I Transcription Initiation";"Formation of the Early Elongation Complex";"Formation of the HIV-1 Early Elongation Complex";"Formation of Incision Complex in GG-NER";"RNA Polymerase II Transcription Initiation";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"HIV Transcription Initiation";"Tat-mediated elongation of the HIV-1 transcript";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Dual incision in TC-NER";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Elongation";"RNA Polymerase II Promoter Escape";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase I Transcription Termination";"Transcription of the HIV genome";"RNA Polymerase I Promoter Escape";"Formation of TC-NER Pre-Incision Complex";"Gap-filling DNA repair synthesis and ligation in TC-NER"
Medex_00073921-RA	1	Reactome: R-HSA-1614517	"Sulfide oxidation to sulfate"
Medex_00006503-RA	13	Reactome: R-HSA-975957;Reactome: R-HSA-192823;Reactome: R-HSA-1799339;Reactome: R-HSA-9633012;Reactome: R-HSA-156902;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-72706;Reactome: R-HSA-975956;Reactome: R-HSA-72764;Reactome: R-HSA-72689;Reactome: R-HSA-2408557;Reactome: R-HSA-6791226	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Viral mRNA Translation";"SRP-dependent cotranslational protein targeting to membrane";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Peptide chain elongation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Formation of a pool of free 40S subunits";"Selenocysteine synthesis";"Major pathway of rRNA processing in the nucleolus and cytosol"
Medex_00025878-RA	6	Reactome: R-HSA-204005;Reactome: R-HSA-6811434;Reactome: R-HSA-6811438;Reactome: R-HSA-416993;Reactome: R-HSA-6807878;Reactome: R-HSA-6811440	"COPII-mediated vesicle transport";"COPI-dependent Golgi-to-ER retrograde traffic";"Intra-Golgi traffic";"Trafficking of GluR2-containing AMPA receptors";"COPI-mediated anterograde transport";"Retrograde transport at the Trans-Golgi-Network"
Medex_00068818-RA	7	MetaCyc: PWY-6614;Reactome: R-HSA-196757;Reactome: R-HSA-69205;MetaCyc: PWY-3841;KEGG: 00790+1.5.1.3;KEGG: 00670+1.5.1.3;Reactome: R-HSA-1474151	"Tetrahydrofolate biosynthesis";"Metabolism of folate and pterines";"G1/S-Specific Transcription";"Folate transformations II (plants)";"Folate biosynthesis";"One carbon pool by folate";"Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation"
Medex_00024725-RA	1	Reactome: R-HSA-975957	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
Medex_00036727-RA	14	MetaCyc: PWY-7601;MetaCyc: PWY-7724;MetaCyc: PWY-5080;MetaCyc: PWY-8041;MetaCyc: PWY-6598;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7725;MetaCyc: PWY-7036;MetaCyc: PWY-7602;MetaCyc: PWY-7619;MetaCyc: PWY-6433;MetaCyc: PWY-7035;Reactome: R-HSA-75876;MetaCyc: PWY-5972	"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Very long chain fatty acid biosynthesis I";"Ultra-long-chain fatty acid biosynthesis";"Sciadonate biosynthesis";"Fatty acid elongation";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Very long chain fatty acid biosynthesis II";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Juniperonate biosynthesis";"Hydroxylated fatty acid biosynthesis (plants)";"(9Z)-tricosene biosynthesis";"Synthesis of very long-chain fatty acyl-CoAs";"Stearate biosynthesis I (animals)"
Medex_00025150-RA	7	Reactome: R-HSA-8854518;Reactome: R-HSA-380320;Reactome: R-HSA-380270;Reactome: R-HSA-2565942;Reactome: R-HSA-380259;Reactome: R-HSA-380284;Reactome: R-HSA-5620912	"AURKA Activation by TPX2";"Recruitment of NuMA to mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes";"Regulation of PLK1 Activity at G2/M Transition";"Loss of Nlp from mitotic centrosomes";"Loss of proteins required for interphase microtubule organization from the centrosome";"Anchoring of the basal body to the plasma membrane"
Medex_00089531-RA	8	MetaCyc: PWY-7199;KEGG: 00240+3.5.4.5;MetaCyc: PWY-7193;MetaCyc: PWY-6556;Reactome: R-HSA-6798695;MetaCyc: PWY-7181;Reactome: R-HSA-73614;KEGG: 00983+3.5.4.5	"Pyrimidine deoxyribonucleosides salvage";"Pyrimidine metabolism";"Pyrimidine ribonucleosides salvage I";"Pyrimidine ribonucleosides salvage II";"Neutrophil degranulation";"Pyrimidine deoxyribonucleosides degradation";"Pyrimidine salvage";"Drug metabolism - other enzymes"
Medex_00001486-RA	10	MetaCyc: PWY-7921;Reactome: R-HSA-162699;KEGG: 00510+2.4.1.83;MetaCyc: PWY-7922;Reactome: R-HSA-4719377;Reactome: R-HSA-4719360;Reactome: R-HSA-913709;MetaCyc: PWY-7979;Reactome: R-HSA-4717374;MetaCyc: PWY-7661	"Protein O-mannosylation I (yeast)";"Synthesis of dolichyl-phosphate mannose";"N-Glycan biosynthesis";"Protein O-mannosylation II (mammals, core M1 and core M2)";"Defective DPM2 causes DPM2-CDG (CDG-1u)";"Defective DPM3 causes DPM3-CDG (CDG-1o)";"O-linked glycosylation of mucins";"Protein O-mannosylation III (mammals, core M3)";"Defective DPM1 causes DPM1-CDG (CDG-1e)";"Protein N-glycosylation (Haloferax volcanii)"
Medex_00011549-RA	4	MetaCyc: PWY-6129;Reactome: R-HSA-446199;Reactome: R-HSA-4755609;KEGG: 00900+2.5.1.87	"Dolichol and dolichyl phosphate biosynthesis";"Synthesis of Dolichyl-phosphate";"Defective DHDDS causes retinitis pigmentosa 59";"Terpenoid backbone biosynthesis"
Medex_00033729-RA	1	Reactome: R-HSA-4615885	"SUMOylation of DNA replication proteins"
Medex_00097015-RA	1	Reactome: R-HSA-212300	"PRC2 methylates histones and DNA"
Medex_00091824-RA	5	Reactome: R-HSA-8856825;Reactome: R-HSA-182971;Reactome: R-HSA-8875360;Reactome: R-HSA-6807004;Reactome: R-HSA-8856828	"Cargo recognition for clathrin-mediated endocytosis";"EGFR downregulation";"InlB-mediated entry of Listeria monocytogenes into host cell";"Negative regulation of MET activity";"Clathrin-mediated endocytosis"
Medex_00008118-RA	12	MetaCyc: PWY-7384;MetaCyc: PWY-5690;KEGG: 00660+6.2.1.5;MetaCyc: PWY-5913;MetaCyc: PWY-6969;MetaCyc: PWY-6728;MetaCyc: PWY-5537;MetaCyc: PWY-5538;KEGG: 00020+6.2.1.5;KEGG: 00640+6.2.1.5;MetaCyc: PWY-5392;KEGG: 00720+6.2.1.5	"Anaerobic energy metabolism (invertebrates, mitochondrial)";"TCA cycle II (plants and fungi)";"C5-Branched dibasic acid metabolism";"Partial TCA cycle (obligate autotrophs)";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Methylaspartate cycle";"Pyruvate fermentation to acetate V";"Pyruvate fermentation to acetate VI";"Citrate cycle (TCA cycle)";"Propanoate metabolism";"Reductive TCA cycle II";"Carbon fixation pathways in prokaryotes"
Medex_00050840-RA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
Medex_00082297-RA	2	Reactome: R-HSA-390471;Reactome: R-HSA-1660662	"Association of TriC/CCT with target proteins during biosynthesis";"Glycosphingolipid metabolism"
Medex_00077886-RA	16	Reactome: R-HSA-167290;Reactome: R-HSA-180585;Reactome: R-HSA-674695;Reactome: R-HSA-167152;Reactome: R-HSA-9010553;Reactome: R-HSA-167243;Reactome: R-HSA-167287;Reactome: R-HSA-75955;Reactome: R-HSA-983168;Reactome: R-HSA-167246;Reactome: R-HSA-167200;Reactome: R-HSA-8951664;Reactome: R-HSA-167238;Reactome: R-HSA-6796648;Reactome: R-HSA-112382;Reactome: R-HSA-1234176	"Pausing and recovery of HIV elongation";"Vif-mediated degradation of APOBEC3G";"RNA Polymerase II Pre-transcription Events";"Formation of HIV elongation complex in the absence of HIV Tat";"Regulation of expression of SLITs and ROBOs";"Tat-mediated HIV elongation arrest and recovery";"HIV elongation arrest and recovery";"RNA Polymerase II Transcription Elongation";"Antigen processing: Ubiquitination & Proteasome degradation";"Tat-mediated elongation of the HIV-1 transcript";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Neddylation";"Pausing and recovery of Tat-mediated HIV elongation";"TP53 Regulates Transcription of DNA Repair Genes";"Formation of RNA Pol II elongation complex";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha"
Medex_00071296-RA	2	Reactome: R-HSA-2682334;Reactome: R-HSA-3928665	"EPH-Ephrin signaling";"EPH-ephrin mediated repulsion of cells"
Medex_00017031-RA	33	Reactome: R-HSA-4570464;Reactome: R-HSA-4085377;Reactome: R-HSA-3301854;Reactome: R-HSA-180910;Reactome: R-HSA-159236;Reactome: R-HSA-3108214;Reactome: R-HSA-6784531;Reactome: R-HSA-9609690;Reactome: R-HSA-9610379;Reactome: R-HSA-5619107;Reactome: R-HSA-180746;Reactome: R-HSA-165054;Reactome: R-HSA-2500257;Reactome: R-HSA-5578749;Reactome: R-HSA-168276;Reactome: R-HSA-3371453;Reactome: R-HSA-4615885;Reactome: R-HSA-170822;Reactome: R-HSA-3232142;Reactome: R-HSA-168271;Reactome: R-HSA-168325;Reactome: R-HSA-191859;Reactome: R-HSA-141444;Reactome: R-HSA-4551638;Reactome: R-HSA-159227;Reactome: R-HSA-9648025;Reactome: R-HSA-159231;Reactome: R-HSA-68877;Reactome: R-HSA-1169408;Reactome: R-HSA-2467813;Reactome: R-HSA-168333;Reactome: R-HSA-159230;Reactome: R-HSA-5663220	"SUMOylation of RNA binding proteins";"SUMOylation of SUMOylation proteins";"Nuclear Pore Complex (NPC) Disassembly";"Vpr-mediated nuclear import of PICs";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"SUMOylation of DNA damage response and repair proteins";"tRNA processing in the nucleus";"HCMV Early Events";"HCMV Late Events";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Nuclear import of Rev protein";"Rev-mediated nuclear export of HIV RNA";"Resolution of Sister Chromatid Cohesion";"Transcriptional regulation by small RNAs";"NS1 Mediated Effects on Host Pathways";"Regulation of HSF1-mediated heat shock response";"SUMOylation of DNA replication proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"SUMOylation of ubiquitinylation proteins";"Transport of Ribonucleoproteins into the Host Nucleus";"Viral Messenger RNA Synthesis";"snRNP Assembly";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"SUMOylation of chromatin organization proteins";"Transport of the SLBP independent Mature mRNA";"EML4 and NUDC in mitotic spindle formation";"Transport of Mature mRNA Derived from an Intronless Transcript";"Mitotic Prometaphase";"ISG15 antiviral mechanism";"Separation of Sister Chromatids";"NEP/NS2 Interacts with the Cellular Export Machinery";"Transport of the SLBP Dependant Mature mRNA";"RHO GTPases Activate Formins"
Medex_00048132-RA	1	Reactome: R-HSA-1799339	"SRP-dependent cotranslational protein targeting to membrane"
Medex_00070754-RA	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
Medex_00054569-RA	3	MetaCyc: PWY-7511;Reactome: R-HSA-8866654;Reactome: R-HSA-110314	"Protein ubiquitination";"E3 ubiquitin ligases ubiquitinate target proteins";"Recognition of DNA damage by PCNA-containing replication complex"
Medex_00082945-RA	3	Reactome: R-HSA-446193;KEGG: 00510+2.7.8.15;Reactome: R-HSA-4549356	"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"N-Glycan biosynthesis";"Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2"
Medex_00056974-RA	5	Reactome: R-HSA-6798695;Reactome: R-HSA-2132295;Reactome: R-HSA-4341670;Reactome: R-HSA-4085001;Reactome: R-HSA-1660662	"Neutrophil degranulation";"MHC class II antigen presentation";"Defective NEU1 causes sialidosis";"Sialic acid metabolism";"Glycosphingolipid metabolism"
Medex_00060419-RA	1	Reactome: R-HSA-71384	"Ethanol oxidation"
Medex_00054981-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Medex_00050686-RA	2	Reactome: R-HSA-8876198;Reactome: R-HSA-6811436	"RAB GEFs exchange GTP for GDP on RABs";"COPI-independent Golgi-to-ER retrograde traffic"
Medex_00011961-RA	1	Reactome: R-HSA-5663220	"RHO GTPases Activate Formins"
Medex_00084796-RA	1	Reactome: R-HSA-8854691	"Interleukin-20 family signaling"
Medex_00062103-RA	56	Reactome: R-HSA-187577;Reactome: R-HSA-174084;Reactome: R-HSA-1236974;Reactome: R-HSA-8854050;Reactome: R-HSA-5610783;Reactome: R-HSA-8948751;Reactome: R-HSA-68827;Reactome: R-HSA-9604323;Reactome: R-HSA-1234176;Reactome: R-HSA-69601;Reactome: R-HSA-69017;Reactome: R-HSA-5362768;Reactome: R-HSA-5676590;Reactome: R-HSA-174113;Reactome: R-HSA-4641257;Reactome: R-HSA-5678895;Reactome: R-HSA-69481;Reactome: R-HSA-350562;Reactome: R-HSA-8951664;Reactome: R-HSA-2871837;Reactome: R-HSA-5607764;Reactome: R-HSA-174184;Reactome: R-HSA-1169091;Reactome: R-HSA-174154;Reactome: R-HSA-9020702;Reactome: R-HSA-983168;Reactome: R-HSA-202424;Reactome: R-HSA-5658442;Reactome: R-HSA-8941858;Reactome: R-HSA-5358346;Reactome: R-HSA-9010553;Reactome: R-HSA-211733;Reactome: R-HSA-8939236;Reactome: R-HSA-382556;Reactome: R-HSA-68949;Reactome: R-HSA-180585;Reactome: R-HSA-450408;Reactome: R-HSA-4641258;Reactome: R-HSA-2467813;Reactome: R-HSA-5687128;Reactome: R-HSA-5689603;Reactome: R-HSA-5668541;Reactome: R-HSA-4608870;Reactome: R-HSA-5610785;Reactome: R-HSA-5689880;Reactome: R-HSA-195253;Reactome: R-HSA-8939902;Reactome: R-HSA-75815;Reactome: R-HSA-174178;Reactome: R-HSA-5607761;Reactome: R-HSA-5610780;Reactome: R-HSA-8852276;Reactome: R-HSA-1236978;Reactome: R-HSA-349425;Reactome: R-HSA-180534;Reactome: R-HSA-5632684	"SCF(Skp2)-mediated degradation of p27/p21";"Autodegradation of Cdh1 by Cdh1:APC/C";"ER-Phagosome pathway";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Degradation of GLI2 by the proteasome";"Regulation of PTEN stability and activity";"CDT1 association with the CDC6:ORC:origin complex";"Negative regulation of NOTCH4 signaling";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"CDK-mediated phosphorylation and removal of Cdc6";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"NIK-->noncanonical NF-kB signaling";"SCF-beta-TrCP mediated degradation of Emi1";"Degradation of AXIN";"Defective CFTR causes cystic fibrosis";"G2/M Checkpoints";"Regulation of ornithine decarboxylase (ODC)";"Neddylation";"FCERI mediated NF-kB activation";"CLEC7A (Dectin-1) signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Activation of NF-kappaB in B cells";"APC/C:Cdc20 mediated degradation of Securin";"Interleukin-1 signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Downstream TCR signaling";"Regulation of RAS by GAPs";"Regulation of RUNX3 expression and activity";"Hedgehog ligand biogenesis";"Regulation of expression of SLITs and ROBOs";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"ABC-family proteins mediated transport";"Orc1 removal from chromatin";"Vif-mediated degradation of APOBEC3G";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Degradation of DVL";"Separation of Sister Chromatids";"MAPK6/MAPK4 signaling";"UCH proteinases";"TNFR2 non-canonical NF-kB pathway";"Asymmetric localization of PCP proteins";"GLI3 is processed to GLI3R by the proteasome";"Ub-specific processing proteases";"Degradation of beta-catenin by the destruction complex";"Regulation of RUNX2 expression and activity";"Ubiquitin-dependent degradation of Cyclin D";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Dectin-1 mediated noncanonical NF-kB signaling";"Degradation of GLI1 by the proteasome";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Cross-presentation of soluble exogenous antigens (endosomes)";"Autodegradation of the E3 ubiquitin ligase COP1";"Vpu mediated degradation of CD4";"Hedgehog 'on' state"
Medex_00025092-RA	3	Reactome: R-HSA-74259;Reactome: R-HSA-73621;Reactome: R-HSA-196807	"Purine catabolism";"Pyrimidine catabolism";"Nicotinate metabolism"
Medex_00018233-RA	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
Medex_00031210-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Medex_00006533-RA	1	Reactome: R-HSA-400253	"Circadian Clock"
Medex_00034370-RA	1	Reactome: R-HSA-5657655	"MGMT-mediated DNA damage reversal"
Medex_00046074-RA	1	Reactome: R-HSA-6798163	"Choline catabolism"
Medex_00024782-RA	22	MetaCyc: PWY-3801;KEGG: 00010+5.3.1.9;MetaCyc: PWY-6142;MetaCyc: PWY-622;MetaCyc: PWY-6992;KEGG: 00500+5.3.1.9;MetaCyc: PWY-621;MetaCyc: PWY-8013;Reactome: R-HSA-5628897;MetaCyc: PWY-5514;Reactome: R-HSA-6798695;Reactome: R-HSA-70263;Reactome: R-HSA-70171;MetaCyc: PWY-5659;MetaCyc: PWY-5054;KEGG: 00030+5.3.1.9;MetaCyc: PWY-7385;MetaCyc: PWY-6981;KEGG: 00520+5.3.1.9;MetaCyc: PWY-7347;MetaCyc: PWY-5384;MetaCyc: PWY-7238	"Sucrose degradation II (sucrose synthase)";"Glycolysis / Gluconeogenesis";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Starch biosynthesis";"1,5-anhydrofructose degradation";"Starch and sucrose metabolism";"Sucrose degradation III (sucrose invertase)";"UDP-N-acetyl-D-galactosamine biosynthesis III";"TP53 Regulates Metabolic Genes";"UDP-N-acetyl-D-galactosamine biosynthesis II";"Neutrophil degranulation";"Gluconeogenesis";"Glycolysis";"GDP-mannose biosynthesis";"D-sorbitol biosynthesis I";"Pentose phosphate pathway";"1,3-propanediol biosynthesis (engineered)";"Chitin biosynthesis";"Amino sugar and nucleotide sugar metabolism";"Sucrose biosynthesis III";"Sucrose degradation IV (sucrose phosphorylase)";"Sucrose biosynthesis II"
Medex_00062436-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Medex_00066913-RA	2	Reactome: R-HSA-373080;Reactome: R-HSA-3238698	"Class B/2 (Secretin family receptors)";"WNT ligand biogenesis and trafficking"
Medex_00063033-RA	2	KEGG: 00500+2.4.1.15;Reactome: R-HSA-446205	"Starch and sucrose metabolism";"Synthesis of GDP-mannose"
Medex_00012702-RA	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
Medex_00095840-RA	2	Reactome: R-HSA-6783310;MetaCyc: PWY-7511	"Fanconi Anemia Pathway";"Protein ubiquitination"
Medex_00006189-RA	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
Medex_00008834-RA	1	Reactome: R-HSA-9633012	"Response of EIF2AK4 (GCN2) to amino acid deficiency"
Medex_00076694-RA	6	KEGG: 04070+2.7.1.107;KEGG: 00561+2.7.1.107;MetaCyc: PWY-7817;KEGG: 00564+2.7.1.107;MetaCyc: PWY-7039;Reactome: R-HSA-114508	"Phosphatidylinositol signaling system";"Glycerolipid metabolism";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Glycerophospholipid metabolism";"Phosphatidate metabolism, as a signaling molecule";"Effects of PIP2 hydrolysis"
Medex_00065220-RA	2	Reactome: R-HSA-877300;Reactome: R-HSA-2132295	"Interferon gamma signaling";"MHC class II antigen presentation"
Medex_00018455-RA	1	Reactome: R-HSA-5689880	"Ub-specific processing proteases"
Medex_00070449-RA	6	MetaCyc: PWY-6722;MetaCyc: PWY-4381;MetaCyc: PWY-5743;Reactome: R-HSA-196780;MetaCyc: PWY-5789;MetaCyc: PWY-5744	"Candicidin biosynthesis";"Fatty acid biosynthesis initiation (bacteria and plants)";"3-hydroxypropanoate cycle";"Biotin transport and metabolism";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Glyoxylate assimilation"
Medex_00016264-RA	5	Reactome: R-HSA-4341670;Reactome: R-HSA-1660662;Reactome: R-HSA-4085001;Reactome: R-HSA-2132295;Reactome: R-HSA-6798695	"Defective NEU1 causes sialidosis";"Glycosphingolipid metabolism";"Sialic acid metabolism";"MHC class II antigen presentation";"Neutrophil degranulation"
Medex_00024509-RA	3	MetaCyc: PWY-7803;Reactome: R-HSA-6784531;MetaCyc: PWY-6689	"Trna splicing II";"tRNA processing in the nucleus";"Trna splicing I"
Medex_00005026-RA	2	Reactome: R-HSA-446193;Reactome: R-HSA-4570571	"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"Defective RFT1 causes RFT1-CDG (CDG-1n)"
Medex_00095878-RA	6	Reactome: R-HSA-2046105;Reactome: R-HSA-1369062;Reactome: R-HSA-2046106;Reactome: R-HSA-9603798;Reactome: R-HSA-390247;Reactome: R-HSA-5684045	"Linoleic acid (LA) metabolism";"ABC transporters in lipid homeostasis";"alpha-linolenic acid (ALA) metabolism";"Class I peroxisomal membrane protein import";"Beta-oxidation of very long chain fatty acids";"Defective ABCD1 causes adrenoleukodystrophy (ALD)"
Medex_00053680-RA	1	Reactome: R-HSA-6798163	"Choline catabolism"
Medex_00082392-RA	1	Reactome: R-HSA-211981	"Xenobiotics"
Medex_00067598-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00028248-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00006437-RA	1	Reactome: R-HSA-429958	"mRNA decay by 3' to 5' exoribonuclease"
Medex_00047868-RA	1	Reactome: R-HSA-391908	"Prostanoid ligand receptors"
Medex_00028608-RA	43	Reactome: R-HSA-5663220;Reactome: R-HSA-163685;Reactome: R-HSA-5358752;Reactome: R-HSA-113501;Reactome: R-HSA-8854518;Reactome: R-HSA-69273;Reactome: R-HSA-380320;Reactome: R-HSA-180024;Reactome: R-HSA-5339716;Reactome: R-HSA-2467813;Reactome: R-HSA-9634600;Reactome: R-HSA-68877;Reactome: R-HSA-380270;Reactome: R-HSA-9648025;Reactome: R-HSA-6804757;Reactome: R-HSA-163767;Reactome: R-HSA-432142;Reactome: R-HSA-195253;Reactome: R-HSA-389513;Reactome: R-HSA-141444;Reactome: R-HSA-6811558;Reactome: R-HSA-5467348;Reactome: R-HSA-5358749;Reactome: R-HSA-198753;Reactome: R-HSA-196299;Reactome: R-HSA-2995383;Reactome: R-HSA-5620912;Reactome: R-HSA-2465910;Reactome: R-HSA-2500257;Reactome: R-HSA-5358747;Reactome: R-HSA-5675221;Reactome: R-HSA-2565942;Reactome: R-HSA-5467337;Reactome: R-HSA-380284;Reactome: R-HSA-5467340;Reactome: R-HSA-4641262;Reactome: R-HSA-1295596;Reactome: R-HSA-202670;Reactome: R-HSA-69231;Reactome: R-HSA-5358751;Reactome: R-HSA-975957;Reactome: R-HSA-5673000;Reactome: R-HSA-380259	"RHO GTPases Activate Formins";"Integration of energy metabolism";"T41 mutants of beta-catenin aren't phosphorylated";"Inhibition of replication initiation of damaged DNA by RB1/E2F1";"AURKA Activation by TPX2";"Cyclin A/B1/B2 associated events during G2/M transition";"Recruitment of NuMA to mitotic centrosomes";"DARPP-32 events";"Misspliced GSK3beta mutants stabilize beta-catenin";"Separation of Sister Chromatids";"Regulation of glycolysis by fructose 2,6-bisphosphate metabolism";"Mitotic Prometaphase";"Recruitment of mitotic centrosome proteins and complexes";"EML4 and NUDC in mitotic spindle formation";"Regulation of TP53 Degradation";"PP2A-mediated dephosphorylation of key metabolic factors";"Platelet sensitization by LDL";"Degradation of beta-catenin by the destruction complex";"CTLA4 inhibitory signaling";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"Truncations of AMER1 destabilize the destruction complex";"S37 mutants of beta-catenin aren't phosphorylated";"ERK/MAPK targets";"Beta-catenin phosphorylation cascade";"Initiation of Nuclear Envelope Reformation";"Anchoring of the basal body to the plasma membrane";"MASTL Facilitates Mitotic Progression";"Resolution of Sister Chromatid Cohesion";"S33 mutants of beta-catenin aren't phosphorylated";"Negative regulation of MAPK pathway";"Regulation of PLK1 Activity at G2/M Transition";"APC truncation mutants have impaired AXIN binding";"Loss of proteins required for interphase microtubule organization from the centrosome";"AXIN missense mutants destabilize the destruction complex";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"Spry regulation of FGF signaling";"ERKs are inactivated";"Cyclin D associated events in G1";"S45 mutants of beta-catenin aren't phosphorylated";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"RAF activation";"Loss of Nlp from mitotic centrosomes"
Medex_00010125-RA	1	Reactome: R-HSA-191859	"snRNP Assembly"
Medex_00031433-RA	42	Reactome: R-HSA-5617472;Reactome: R-HSA-2559586;Reactome: R-HSA-9018519;Reactome: R-HSA-3214858;Reactome: R-HSA-3214841;Reactome: R-HSA-427389;Reactome: R-HSA-5578749;Reactome: R-HSA-2559582;Reactome: R-HSA-2559580;Reactome: R-HSA-110329;Reactome: R-HSA-171306;Reactome: R-HSA-5250924;Reactome: R-HSA-110331;Reactome: R-HSA-606279;Reactome: R-HSA-212300;Reactome: R-HSA-1221632;Reactome: R-HSA-9609690;Reactome: R-HSA-9610379;Reactome: R-HSA-1912408;Reactome: R-HSA-5693571;Reactome: R-HSA-977225;Reactome: R-HSA-427359;Reactome: R-HSA-5334118;Reactome: R-HSA-110328;Reactome: R-HSA-2299718;Reactome: R-HSA-3214815;Reactome: R-HSA-110330;Reactome: R-HSA-5693565;Reactome: R-HSA-8936459;Reactome: R-HSA-5625886;Reactome: R-HSA-3214842;Reactome: R-HSA-69473;Reactome: R-HSA-73728;Reactome: R-HSA-73772;Reactome: R-HSA-5693607;Reactome: R-HSA-8939236;Reactome: R-HSA-4551638;Reactome: R-HSA-9616222;Reactome: R-HSA-3214847;Reactome: R-HSA-427413;Reactome: R-HSA-201722;Reactome: R-HSA-912446	"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"DNA Damage/Telomere Stress Induced Senescence";"Estrogen-dependent gene expression";"RMTs methylate histone arginines";"PKMTs methylate histone lysines";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"Transcriptional regulation by small RNAs";"Senescence-Associated Secretory Phenotype (SASP)";"Oxidative Stress Induced Senescence";"Cleavage of the damaged pyrimidine";"Packaging Of Telomere Ends";"B-WICH complex positively regulates rRNA expression";"Cleavage of the damaged purine";"Deposition of new CENPA-containing nucleosomes at the centromere";"PRC2 methylates histones and DNA";"Meiotic synapsis";"HCMV Early Events";"HCMV Late Events";"Pre-NOTCH Transcription and Translation";"Nonhomologous End-Joining (NHEJ)";"Amyloid fiber formation";"SIRT1 negatively regulates rRNA expression";"DNA methylation";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"Condensation of Prophase Chromosomes";"HDACs deacetylate histones";"Recognition and association of DNA glycosylase with site containing an affected purine";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3";"HDMs demethylate histones";"G2/M DNA damage checkpoint";"RNA Polymerase I Promoter Opening";"RNA Polymerase I Promoter Escape";"Processing of DNA double-strand break ends";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"SUMOylation of chromatin organization proteins";"Transcriptional regulation of granulopoiesis";"HATs acetylate histones";"NoRC negatively regulates rRNA expression";"Formation of the beta-catenin:TCF transactivating complex";"Meiotic recombination"
Medex_00024205-RA	2	KEGG: 00480+1.11.1.15;Reactome: R-HSA-3299685	"Glutathione metabolism";"Detoxification of Reactive Oxygen Species"
Medex_00023802-RA	10	MetaCyc: PWY-7587;MetaCyc: PWY-7411;KEGG: 00561+2.3.1.15;MetaCyc: PWY-8055;MetaCyc: PWY-5667;MetaCyc: PWY-6453;MetaCyc: PWY-8051;KEGG: 00564+2.3.1.15;Reactome: R-HSA-1483166;MetaCyc: PWY-8053	"Oleate biosynthesis III (cyanobacteria)";"Phosphatidate biosynthesis (yeast)";"Glycerolipid metabolism";"Palmitoyl ethanolamide biosynthesis";"CDP-diacylglycerol biosynthesis I";"Stigma estolide biosynthesis";"Anandamide biosynthesis I";"Glycerophospholipid metabolism";"Synthesis of PA";"Anandamide biosynthesis II"
Medex_00033867-RA	3	Reactome: R-HSA-5173105;KEGG: 00515+2.7.1.183;MetaCyc: PWY-7979	"O-linked glycosylation";"Mannose type O-glycan biosynthesis";"Protein O-mannosylation III (mammals, core M3)"
Medex_00043043-RA	13	MetaCyc: PWY-5537;MetaCyc: PWY-6728;MetaCyc: PWY-5913;MetaCyc: PWY-6969;MetaCyc: PWY-7384;KEGG: 00660+6.2.1.5;MetaCyc: PWY-5690;MetaCyc: PWY-5392;KEGG: 00640+6.2.1.5;KEGG: 00720+6.2.1.5;KEGG: 00020+6.2.1.5;MetaCyc: PWY-5538;Reactome: R-HSA-71403	"Pyruvate fermentation to acetate V";"Methylaspartate cycle";"Partial TCA cycle (obligate autotrophs)";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Anaerobic energy metabolism (invertebrates, mitochondrial)";"C5-Branched dibasic acid metabolism";"TCA cycle II (plants and fungi)";"Reductive TCA cycle II";"Propanoate metabolism";"Carbon fixation pathways in prokaryotes";"Citrate cycle (TCA cycle)";"Pyruvate fermentation to acetate VI";"Citric acid cycle (TCA cycle)"
Medex_00035109-RA	2	Reactome: R-HSA-1169408;Reactome: R-HSA-168276	"ISG15 antiviral mechanism";"NS1 Mediated Effects on Host Pathways"
Medex_00006638-RA	1	KEGG: 00480+3.4.11.2	"Glutathione metabolism"
Medex_00044250-RA	13	Reactome: R-HSA-3000157;Reactome: R-HSA-419037;Reactome: R-HSA-1474244;Reactome: R-HSA-2214320;Reactome: R-HSA-3000171;Reactome: R-HSA-186797;Reactome: R-HSA-3000178;Reactome: R-HSA-1442490;Reactome: R-HSA-2243919;Reactome: R-HSA-216083;Reactome: R-HSA-1650814;Reactome: R-HSA-2022090;Reactome: R-HSA-8948216	"Laminin interactions";"NCAM1 interactions";"Extracellular matrix organization";"Anchoring fibril formation";"Non-integrin membrane-ECM interactions";"Signaling by PDGF";"ECM proteoglycans";"Collagen degradation";"Crosslinking of collagen fibrils";"Integrin cell surface interactions";"Collagen biosynthesis and modifying enzymes";"Assembly of collagen fibrils and other multimeric structures";"Collagen chain trimerization"
Medex_00085565-RA	1	Reactome: R-HSA-1632852	"Macroautophagy"
Medex_00064490-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00041369-RA	24	Reactome: R-HSA-8852276;Reactome: R-HSA-9609736;Reactome: R-HSA-983189;Reactome: R-HSA-2132295;Reactome: R-HSA-5626467;Reactome: R-HSA-8955332;Reactome: R-HSA-6811436;Reactome: R-HSA-9609690;Reactome: R-HSA-6807878;Reactome: R-HSA-437239;Reactome: R-HSA-190840;Reactome: R-HSA-190861;Reactome: R-HSA-9619483;Reactome: R-HSA-6811434;Reactome: R-HSA-9648025;Reactome: R-HSA-68877;Reactome: R-HSA-9646399;Reactome: R-HSA-5617833;Reactome: R-HSA-2467813;Reactome: R-HSA-3371497;Reactome: R-HSA-380320;Reactome: R-HSA-2500257;Reactome: R-HSA-1445148;Reactome: R-HSA-5663220	"The role of GTSE1 in G2/M progression after G2 checkpoint";"Assembly and cell surface presentation of NMDA receptors";"Kinesins";"MHC class II antigen presentation";"RHO GTPases activate IQGAPs";"Carboxyterminal post-translational modifications of tubulin";"COPI-independent Golgi-to-ER retrograde traffic";"HCMV Early Events";"COPI-mediated anterograde transport";"Recycling pathway of L1";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Gap junction assembly";"Activation of AMPK downstream of NMDARs";"COPI-dependent Golgi-to-ER retrograde traffic";"EML4 and NUDC in mitotic spindle formation";"Mitotic Prometaphase";"Aggrephagy";"Cilium Assembly";"Separation of Sister Chromatids";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Recruitment of NuMA to mitotic centrosomes";"Resolution of Sister Chromatid Cohesion";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"RHO GTPases Activate Formins"
Medex_00045252-RA	1	Reactome: R-HSA-9037629	"Lewis blood group biosynthesis"
Medex_00029294-RA	6	Reactome: R-HSA-72706;Reactome: R-HSA-72689;Reactome: R-HSA-72649;Reactome: R-HSA-72702;Reactome: R-HSA-72695;Reactome: R-HSA-156827	"GTP hydrolysis and joining of the 60S ribosomal subunit";"Formation of a pool of free 40S subunits";"Translation initiation complex formation";"Ribosomal scanning and start codon recognition";"Formation of the ternary complex, and subsequently, the 43S complex";"L13a-mediated translational silencing of Ceruloplasmin expression"
Medex_00023686-RA	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
Medex_00010894-RA	5	Reactome: R-HSA-163765;Reactome: R-HSA-2426168;Reactome: R-HSA-75105;Reactome: R-HSA-9029558;Reactome: R-HSA-199220	"ChREBP activates metabolic gene expression";"Activation of gene expression by SREBF (SREBP)";"Fatty acyl-CoA biosynthesis";"NR1H2 & NR1H3 regulate gene expression linked to lipogenesis";"Vitamin B5 (pantothenate) metabolism"
Medex_00004401-RA	1	Reactome: R-HSA-2024096	"HS-GAG degradation"
Medex_00014189-RA	1	KEGG: 00970+6.1.1.19	"Aminoacyl-tRNA biosynthesis"
Medex_00055014-RA	13	MetaCyc: PWY-5122;MetaCyc: PWY-7709;MetaCyc: PWY-5123;MetaCyc: PWY-7736;MetaCyc: PWY-7102;MetaCyc: PWY-7410;KEGG: 00900+2.5.1.10+2.5.1.1;MetaCyc: PWY-6383;MetaCyc: PWY-7659;MetaCyc: PWY-7141;MetaCyc: PWY-6859;MetaCyc: PWY-7182;MetaCyc: PWY-7721	"Geranyl diphosphate biosynthesis";"(3R)-linalool biosynthesis";"Trans, trans-farnesyl diphosphate biosynthesis";"Stellatic acid biosynthesis";"Bisabolene biosynthesis (engineered)";"Ipsdienol biosynthesis";"Terpenoid backbone biosynthesis";"Mono-trans, poly-cis decaprenyl phosphate biosynthesis";"Viridicatumtoxin biosynthesis";"(3S)-linalool biosynthesis";"All-trans-farnesol biosynthesis";"Linalool biosynthesis I";"Methyl phomopsenoate biosynthesis"
Medex_00045354-RA	6	MetaCyc: PWY-5884;Reactome: R-HSA-9640463;KEGG: 00073+1.2.1.84;MetaCyc: PWY-7656;MetaCyc: PWY-7782;MetaCyc: PWY-6733	"Wax esters biosynthesis I";"Wax biosynthesis";"Cutin, suberine and wax biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Plasmalogen biosynthesis";"Sporopollenin precursors biosynthesis"
Medex_00009572-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Medex_00048139-RA	3	KEGG: 00230+2.7.6.1;Reactome: R-HSA-73843;KEGG: 00030+2.7.6.1	"Purine metabolism";"5-Phosphoribose 1-diphosphate biosynthesis";"Pentose phosphate pathway"
Medex_00018616-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Medex_00047434-RA	6	Reactome: R-HSA-72706;Reactome: R-HSA-72689;Reactome: R-HSA-72702;Reactome: R-HSA-72649;Reactome: R-HSA-156827;Reactome: R-HSA-72695	"GTP hydrolysis and joining of the 60S ribosomal subunit";"Formation of a pool of free 40S subunits";"Ribosomal scanning and start codon recognition";"Translation initiation complex formation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Formation of the ternary complex, and subsequently, the 43S complex"
Medex_00043367-RA	3	KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway"
Medex_00045863-RA	2	Reactome: R-HSA-1660662;Reactome: R-HSA-390471	"Glycosphingolipid metabolism";"Association of TriC/CCT with target proteins during biosynthesis"
Medex_00044112-RA	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
Medex_00018236-RA	1	KEGG: 00970+6.1.1.2	"Aminoacyl-tRNA biosynthesis"
Medex_00052050-RA	1	Reactome: R-HSA-8951664	"Neddylation"
Medex_00031615-RA	3	Reactome: R-HSA-5696394;Reactome: R-HSA-5689603;Reactome: R-HSA-3214847	"DNA Damage Recognition in GG-NER";"UCH proteinases";"HATs acetylate histones"
Medex_00006861-RA	31	Reactome: R-HSA-75105;MetaCyc: PWY-5971;Reactome: R-HSA-9029558;MetaCyc: PWY-6113;MetaCyc: PWY-7388;Reactome: R-HSA-2426168;MetaCyc: PWY-4381;KEGG: 00061+1.1.1.100+2.3.1.85+4.2.1.59+2.3.1.39+2.3.1.41+3.1.2.14;MetaCyc: PWY-6519;MetaCyc: PWY-5989;Reactome: R-HSA-199220;MetaCyc: PWY-8047;MetaCyc: PWY-6799;MetaCyc: PWY-7746;MetaCyc: PWY-8049;MetaCyc: PWY-5367;MetaCyc: PWY-5147;KEGG: 00780+1.1.1.100+4.2.1.59+2.3.1.41;MetaCyc: PWYG-321;MetaCyc: PWY-5966-1;MetaCyc: PWY-6282;MetaCyc: PWY-7663;MetaCyc: PWY-7723;MetaCyc: PWY-8012;MetaCyc: PWY-5994;Reactome: R-HSA-163765;MetaCyc: PWY-5973;MetaCyc: PWY-7858;MetaCyc: PWY-7664;MetaCyc: PWY-5366;MetaCyc: PWY-5142	"Fatty acyl-CoA biosynthesis";"Palmitate biosynthesis II (bacteria and plant cytoplasm)";"NR1H2 & NR1H3 regulate gene expression linked to lipogenesis";"Superpathway of mycolate biosynthesis";"Octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast)";"Activation of gene expression by SREBF (SREBP)";"Fatty acid biosynthesis initiation (bacteria and plants)";"Fatty acid biosynthesis";"8-amino-7-oxononanoate biosynthesis I";"Stearate biosynthesis II (bacteria and plants)";"Vitamin B5 (pantothenate) metabolism";"Bryostatin biosynthesis";"Fatty acid biosynthesis initiation (plant mitochondria)";"Mycobacterial sulfolipid biosynthesis";"Pederin biosynthesis";"Petroselinate biosynthesis";"Oleate biosynthesis I (plants)";"Biotin metabolism";"";"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)";"Palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate)";"Gondoate biosynthesis (anaerobic)";"Bacterial bioluminescence";"Mupirocin biosynthesis";"Palmitate biosynthesis (animals and fungi, cytoplasm)";"ChREBP activates metabolic gene expression";"Cis-vaccenate biosynthesis";"(5Z)-dodecenoate biosynthesis II";"Oleate biosynthesis IV (anaerobic)";"Palmitoleate biosynthesis II (plants and bacteria)";"Acyl-[acyl-carrier protein] thioesterase pathway"
Medex_00084749-RA	1	Reactome: R-HSA-77108	"Utilization of Ketone Bodies"
Medex_00039998-RA	1	Reactome: R-HSA-6783984	"Glycine degradation"
Medex_00047870-RA	1	Reactome: R-HSA-3299685	"Detoxification of Reactive Oxygen Species"
Medex_00081292-RA	52	Reactome: R-HSA-167243;Reactome: R-HSA-73863;Reactome: R-HSA-167287;Reactome: R-HSA-674695;Reactome: R-HSA-167152;Reactome: R-HSA-73776;Reactome: R-HSA-6782210;Reactome: R-HSA-73772;Reactome: R-HSA-72165;Reactome: R-HSA-73780;Reactome: R-HSA-76061;Reactome: R-HSA-167162;Reactome: R-HSA-76042;Reactome: R-HSA-6803529;Reactome: R-HSA-73762;Reactome: R-HSA-6781827;Reactome: R-HSA-167158;Reactome: R-HSA-72203;Reactome: R-HSA-427413;Reactome: R-HSA-168325;Reactome: R-HSA-77075;Reactome: R-HSA-72086;Reactome: R-HSA-6796648;Reactome: R-HSA-167238;Reactome: R-HSA-749476;Reactome: R-HSA-5250924;Reactome: R-HSA-76066;Reactome: R-HSA-167242;Reactome: R-HSA-72163;Reactome: R-HSA-167172;Reactome: R-HSA-167290;Reactome: R-HSA-6781823;Reactome: R-HSA-167200;Reactome: R-HSA-5578749;Reactome: R-HSA-167246;Reactome: R-HSA-167160;Reactome: R-HSA-5617472;Reactome: R-HSA-203927;Reactome: R-HSA-5601884;Reactome: R-HSA-9018519;Reactome: R-HSA-75955;Reactome: R-HSA-6782135;Reactome: R-HSA-113418;Reactome: R-HSA-1834949;Reactome: R-HSA-6807505;Reactome: R-HSA-167161;Reactome: R-HSA-75953;Reactome: R-HSA-8851708;Reactome: R-HSA-112382;Reactome: R-HSA-73779;Reactome: R-HSA-73980;Reactome: R-HSA-76071	"Tat-mediated HIV elongation arrest and recovery";"RNA Polymerase I Transcription Termination";"HIV elongation arrest and recovery";"RNA Polymerase II Pre-transcription Events";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Polymerase II Promoter Escape";"Gap-filling DNA repair synthesis and ligation in TC-NER";"RNA Polymerase I Promoter Escape";"mRNA Splicing - Minor Pathway";"RNA Polymerase III Chain Elongation";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"FGFR2 alternative splicing";"RNA Polymerase I Transcription Initiation";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Formation of the HIV-1 Early Elongation Complex";"Processing of Capped Intron-Containing Pre-mRNA";"NoRC negatively regulates rRNA expression";"Viral Messenger RNA Synthesis";"RNA Pol II CTD phosphorylation and interaction with CE";"mRNA Capping";"TP53 Regulates Transcription of DNA Repair Genes";"Pausing and recovery of Tat-mediated HIV elongation";"RNA Polymerase III Abortive And Retractive Initiation";"B-WICH complex positively regulates rRNA expression";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"Abortive elongation of HIV-1 transcript in the absence of Tat";"mRNA Splicing - Major Pathway";"Transcription of the HIV genome";"Pausing and recovery of HIV elongation";"Formation of TC-NER Pre-Incision Complex";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Transcriptional regulation by small RNAs";"Tat-mediated elongation of the HIV-1 transcript";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"MicroRNA (miRNA) biogenesis";"PIWI-interacting RNA (piRNA) biogenesis";"Estrogen-dependent gene expression";"RNA Polymerase II Transcription Elongation";"Dual incision in TC-NER";"Formation of the Early Elongation Complex";"Cytosolic sensors of pathogen-associated DNA";"RNA polymerase II transcribes snRNA genes";"HIV Transcription Initiation";"RNA Polymerase II Transcription Initiation";"Signaling by FGFR2 IIIa TM";"Formation of RNA Pol II elongation complex";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase III Transcription Termination";"RNA Polymerase III Transcription Initiation From Type 3 Promoter"
Medex_00028187-RA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Medex_00049516-RA	5	Reactome: R-HSA-1655829;Reactome: R-HSA-5694530;Reactome: R-HSA-2132295;Reactome: R-HSA-204005;Reactome: R-HSA-983170	"Regulation of cholesterol biosynthesis by SREBP (SREBF)";"Cargo concentration in the ER";"MHC class II antigen presentation";"COPII-mediated vesicle transport";"Antigen Presentation: Folding, assembly and peptide loading of class I MHC"
Medex_00026676-RA	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
Medex_00102578-RA	1	Reactome: R-HSA-6798163	"Choline catabolism"
Medex_00008612-RA	1	Reactome: R-HSA-6804756	"Regulation of TP53 Activity through Phosphorylation"
Medex_00041032-RA	18	MetaCyc: PWY-7416;MetaCyc: PWY-7409;MetaCyc: PWY-6803;Reactome: R-HSA-1482839;MetaCyc: PWY-7417;MetaCyc: PWY-8053;Reactome: R-HSA-1482922;KEGG: 00592+3.1.1.4;Reactome: R-HSA-1482925;MetaCyc: PWY-7783;KEGG: 00565+3.1.1.4;KEGG: 00590+3.1.1.4;MetaCyc: PWY-8051;Reactome: R-HSA-1483166;KEGG: 00591+3.1.1.4;Reactome: R-HSA-1482801;KEGG: 00564+3.1.1.4;Reactome: R-HSA-1482788	"Phospholipid remodeling (phosphatidylcholine, yeast)";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Phosphatidylcholine acyl editing";"Acyl chain remodelling of PE";"Phospholipid remodeling (phosphatidate, yeast)";"Anandamide biosynthesis II";"Acyl chain remodelling of PI";"alpha-Linolenic acid metabolism";"Acyl chain remodelling of PG";"Plasmalogen degradation";"Ether lipid metabolism";"Arachidonic acid metabolism";"Anandamide biosynthesis I";"Synthesis of PA";"Linoleic acid metabolism";"Acyl chain remodelling of PS";"Glycerophospholipid metabolism";"Acyl chain remodelling of PC"
Medex_00004153-RA	2	Reactome: R-HSA-446193;Reactome: R-HSA-5633231	"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)"
Medex_00009522-RA	2	KEGG: 00240+3.6.1.23;KEGG: 00983+3.6.1.23	"Pyrimidine metabolism";"Drug metabolism - other enzymes"
Medex_00013690-RA	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
Medex_00030761-RA	3	Reactome: R-HSA-6784531;MetaCyc: PWY-6689;MetaCyc: PWY-7803	"tRNA processing in the nucleus";"Trna splicing I";"Trna splicing II"
Medex_00091000-RA	6	KEGG: 00073+1.2.1.84;MetaCyc: PWY-7782;MetaCyc: PWY-6733;MetaCyc: PWY-7656;Reactome: R-HSA-9640463;MetaCyc: PWY-5884	"Cutin, suberine and wax biosynthesis";"Plasmalogen biosynthesis";"Sporopollenin precursors biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Wax biosynthesis";"Wax esters biosynthesis I"
Medex_00072708-RA	1	Reactome: R-HSA-379716	"Cytosolic tRNA aminoacylation"
Medex_00064876-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Medex_00075669-RA	6	KEGG: 00604+3.2.1.23;KEGG: 00600+3.2.1.23;KEGG: 00511+3.2.1.23;MetaCyc: PWY-6807;KEGG: 00531+3.2.1.23;KEGG: 00052+3.2.1.23	"Glycosphingolipid biosynthesis - ganglio series";"Sphingolipid metabolism";"Other glycan degradation";"Xyloglucan degradation II (exoglucanase)";"Glycosaminoglycan degradation";"Galactose metabolism"
Medex_00060250-RA	2	KEGG: 00561+2.3.1.20;KEGG: 00073+2.3.1.20	"Glycerolipid metabolism";"Cutin, suberine and wax biosynthesis"
Medex_00017135-RA	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
Medex_00005127-RA	2	Reactome: R-HSA-9010553;Reactome: R-HSA-975957	"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
Medex_00027425-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00079462-RA	13	Reactome: R-HSA-1799339;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-156902;Reactome: R-HSA-9633012;Reactome: R-HSA-975957;Reactome: R-HSA-192823;Reactome: R-HSA-2408557;Reactome: R-HSA-6791226;Reactome: R-HSA-975956;Reactome: R-HSA-72706;Reactome: R-HSA-72689;Reactome: R-HSA-72764	"SRP-dependent cotranslational protein targeting to membrane";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Peptide chain elongation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Viral mRNA Translation";"Selenocysteine synthesis";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Formation of a pool of free 40S subunits";"Eukaryotic Translation Termination"
Medex_00050417-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00049876-RA	4	MetaCyc: PWY-5188;Reactome: R-HSA-189451;MetaCyc: PWY-5189;KEGG: 00860+2.5.1.61	"Tetrapyrrole biosynthesis I (from glutamate)";"Heme biosynthesis";"Tetrapyrrole biosynthesis II (from glycine)";"Porphyrin and chlorophyll metabolism"
Medex_00066328-RA	2	Reactome: R-HSA-8963888;Reactome: R-HSA-8866423	"Chylomicron assembly";"VLDL assembly"
Medex_00069432-RA	4	Reactome: R-HSA-350054;Reactome: R-HSA-2894862;Reactome: R-HSA-2122947;Reactome: R-HSA-2644606	"Notch-HLH transcription pathway";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"NOTCH1 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 PEST Domain Mutants"
Medex_00029851-RA	14	MetaCyc: PWY-7619;MetaCyc: PWY-7602;MetaCyc: PWY-7036;MetaCyc: PWY-6433;MetaCyc: PWY-7035;Reactome: R-HSA-75876;MetaCyc: PWY-5972;MetaCyc: PWY-7724;MetaCyc: PWY-7601;MetaCyc: PWY-5080;MetaCyc: PWY-8041;MetaCyc: PWY-7725;KEGG: 00062+2.3.1.199;MetaCyc: PWY-6598	"Juniperonate biosynthesis";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis II";"Hydroxylated fatty acid biosynthesis (plants)";"(9Z)-tricosene biosynthesis";"Synthesis of very long-chain fatty acyl-CoAs";"Stearate biosynthesis I (animals)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis I";"Ultra-long-chain fatty acid biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Fatty acid elongation";"Sciadonate biosynthesis"
Medex_00049556-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Medex_00037882-RA	5	Reactome: R-HSA-4655427;Reactome: R-HSA-427413;Reactome: R-HSA-212300;KEGG: 00270+2.1.1.37;Reactome: R-HSA-5334118	"SUMOylation of DNA methylation proteins";"NoRC negatively regulates rRNA expression";"PRC2 methylates histones and DNA";"Cysteine and methionine metabolism";"DNA methylation"
Medex_00045346-RA	3	Reactome: R-HSA-1236974;Reactome: R-HSA-983170;Reactome: R-HSA-901042	"ER-Phagosome pathway";"Antigen Presentation: Folding, assembly and peptide loading of class I MHC";"Calnexin/calreticulin cycle"
Medex_00019389-RA	1	Reactome: R-HSA-9022692	"Regulation of MECP2 expression and activity"
Medex_00045520-RA	3	Reactome: R-HSA-947581;KEGG: 00790+4.6.1.17;MetaCyc: PWY-6823	"Molybdenum cofactor biosynthesis";"Folate biosynthesis";"Molybdenum cofactor biosynthesis"
Medex_00081291-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Medex_00063816-RA	5	Reactome: R-HSA-174490;Reactome: R-HSA-9615710;Reactome: R-HSA-917729;Reactome: R-HSA-162588;Reactome: R-HSA-9610379	"Membrane binding and targetting of GAG proteins";"Late endosomal microautophagy";"Endosomal Sorting Complex Required For Transport (ESCRT)";"Budding and maturation of HIV virion";"HCMV Late Events"
Medex_00070896-RA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Medex_00070185-RA	1	Reactome: R-HSA-2470946	"Cohesin Loading onto Chromatin"
Medex_00064369-RA	6	Reactome: R-HSA-9640463;MetaCyc: PWY-5884;KEGG: 00073+1.2.1.84;MetaCyc: PWY-7782;MetaCyc: PWY-7656;MetaCyc: PWY-6733	"Wax biosynthesis";"Wax esters biosynthesis I";"Cutin, suberine and wax biosynthesis";"Plasmalogen biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Sporopollenin precursors biosynthesis"
Medex_00069321-RA	3	Reactome: R-HSA-749476;Reactome: R-HSA-76066;Reactome: R-HSA-76061	"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Transcription Initiation From Type 1 Promoter"
Medex_00078295-RA	1	Reactome: R-HSA-216083	"Integrin cell surface interactions"
Medex_00059037-RA	1	Reactome: R-HSA-5620922	"BBSome-mediated cargo-targeting to cilium"
Medex_00012498-RA	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
Medex_00091181-RA	4	MetaCyc: PWY-7790;MetaCyc: PWY-7791;MetaCyc: PWY-5686;KEGG: 00240+3.5.2.3	"UMP biosynthesis II";"UMP biosynthesis III";"UMP biosynthesis I";"Pyrimidine metabolism"
Medex_00048730-RA	29	Reactome: R-HSA-69473;Reactome: R-HSA-5358565;Reactome: R-HSA-6804756;Reactome: R-HSA-5656169;Reactome: R-HSA-110320;Reactome: R-HSA-6783310;Reactome: R-HSA-176187;Reactome: R-HSA-6782135;Reactome: R-HSA-5358606;Reactome: R-HSA-110314;Reactome: R-HSA-3371453;Reactome: R-HSA-68962;Reactome: R-HSA-5693607;Reactome: R-HSA-5685938;Reactome: R-HSA-69166;Reactome: R-HSA-3371511;Reactome: R-HSA-6782210;Reactome: R-HSA-3108214;Reactome: R-HSA-5651801;Reactome: R-HSA-5655862;Reactome: R-HSA-5696400;Reactome: R-HSA-5696397;Reactome: R-HSA-110312;Reactome: R-HSA-5685942;Reactome: R-HSA-174437;Reactome: R-HSA-5696395;Reactome: R-HSA-912446;Reactome: R-HSA-5656121;Reactome: R-HSA-5693616	"G2/M DNA damage checkpoint";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"Regulation of TP53 Activity through Phosphorylation";"Termination of translesion DNA synthesis";"Translesion Synthesis by POLH";"Fanconi Anemia Pathway";"Activation of ATR in response to replication stress";"Dual incision in TC-NER";"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"Recognition of DNA damage by PCNA-containing replication complex";"Regulation of HSF1-mediated heat shock response";"Activation of the pre-replicative complex";"Processing of DNA double-strand break ends";"HDR through Single Strand Annealing (SSA)";"Removal of the Flap Intermediate";"HSF1 activation";"Gap-filling DNA repair synthesis and ligation in TC-NER";"SUMOylation of DNA damage response and repair proteins";"PCNA-Dependent Long Patch Base Excision Repair";"Translesion synthesis by POLK";"Dual Incision in GG-NER";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Translesion synthesis by REV1";"HDR through Homologous Recombination (HRR)";"Removal of the Flap Intermediate from the C-strand";"Formation of Incision Complex in GG-NER";"Meiotic recombination";"Translesion synthesis by POLI";"Presynaptic phase of homologous DNA pairing and strand exchange"
Medex_00072505-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00019415-RA	6	KEGG: 00052+3.2.1.23;KEGG: 00531+3.2.1.23;KEGG: 00511+3.2.1.23;KEGG: 00600+3.2.1.23;MetaCyc: PWY-6807;KEGG: 00604+3.2.1.23	"Galactose metabolism";"Glycosaminoglycan degradation";"Other glycan degradation";"Sphingolipid metabolism";"Xyloglucan degradation II (exoglucanase)";"Glycosphingolipid biosynthesis - ganglio series"
Medex_00030202-RA	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
Medex_00006221-RA	1	Reactome: R-HSA-169911	"Regulation of Apoptosis"
Medex_00053151-RA	5	Reactome: R-HSA-163765;Reactome: R-HSA-2426168;Reactome: R-HSA-199220;Reactome: R-HSA-75105;Reactome: R-HSA-9029558	"ChREBP activates metabolic gene expression";"Activation of gene expression by SREBF (SREBP)";"Vitamin B5 (pantothenate) metabolism";"Fatty acyl-CoA biosynthesis";"NR1H2 & NR1H3 regulate gene expression linked to lipogenesis"
Medex_00030505-RA	3	Reactome: R-HSA-73856;Reactome: R-HSA-72187;Reactome: R-HSA-159236	"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing";"Transport of Mature mRNA derived from an Intron-Containing Transcript"
Medex_00073497-RA	2	Reactome: R-HSA-3238698;Reactome: R-HSA-373080	"WNT ligand biogenesis and trafficking";"Class B/2 (Secretin family receptors)"
Medex_00005901-RA	17	MetaCyc: PWY-6627;MetaCyc: PWY-5695;MetaCyc: PWY-6609;MetaCyc: PWY-6608;Reactome: R-HSA-74217;MetaCyc: PWY-5532;KEGG: 00240+2.4.2.1;MetaCyc: PWY-7179-1;KEGG: 00760+2.4.2.1;MetaCyc: PWY-6611;MetaCyc: PWY-6620;KEGG: 00230+2.4.2.1;MetaCyc: PWY-7179;Reactome: R-HSA-6798695;MetaCyc: PWY-6644;Reactome: R-HSA-74259;MetaCyc: PWY-4202	"Salinosporamide A biosynthesis";"Inosine 5'-phosphate degradation";"Adenine and adenosine salvage III";"Guanosine nucleotides degradation III";"Purine salvage";"Nucleoside and nucleotide degradation (archaea)";"Pyrimidine metabolism";"Purine deoxyribonucleosides degradation II";"Nicotinate and nicotinamide metabolism";"Adenine and adenosine salvage V";"Guanine and guanosine salvage";"Purine metabolism";"Purine deoxyribonucleosides degradation I";"Neutrophil degranulation";"Fluoroacetate and fluorothreonine biosynthesis";"Purine catabolism";"Arsenate detoxification I (mammalian)"
Medex_00045473-RA	3	Reactome: R-HSA-212436;Reactome: R-HSA-381340;Reactome: R-HSA-1989781	"Generic Transcription Pathway";"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression"
Medex_00090744-RA	1	Reactome: R-HSA-6798163	"Choline catabolism"
Medex_00005829-RA	19	Reactome: R-HSA-936837;Reactome: R-HSA-9620244;Reactome: R-HSA-9649948;Reactome: R-HSA-9022692;Reactome: R-HSA-6802946;Reactome: R-HSA-111932;Reactome: R-HSA-3371571;Reactome: R-HSA-5673001;Reactome: R-HSA-6802952;Reactome: R-HSA-877300;Reactome: R-HSA-6802955;Reactome: R-HSA-5576892;Reactome: R-HSA-399719;Reactome: R-HSA-9617324;Reactome: R-HSA-438066;Reactome: R-HSA-5578775;Reactome: R-HSA-5673000;Reactome: R-HSA-442982;Reactome: R-HSA-9609736	"Ion transport by P-type ATPases";"Long-term potentiation";"Signaling downstream of RAS mutants";"Regulation of MECP2 expression and activity";"Signaling by moderate kinase activity BRAF mutants";"CaMK IV-mediated phosphorylation of CREB";"HSF1-dependent transactivation";"RAF/MAP kinase cascade";"Signaling by BRAF and RAF fusions";"Interferon gamma signaling";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"Phase 0 - rapid depolarisation";"Trafficking of AMPA receptors";"Negative regulation of NMDA receptor-mediated neuronal transmission";"Unblocking of NMDA receptors, glutamate binding and activation";"Ion homeostasis";"RAF activation";"Ras activation upon Ca2+ influx through NMDA receptor";"Assembly and cell surface presentation of NMDA receptors"
Medex_00041980-RA	1	Reactome: R-HSA-110357	"Displacement of DNA glycosylase by APEX1"
Medex_00071910-RA	16	Reactome: R-HSA-5685938;Reactome: R-HSA-5693607;Reactome: R-HSA-2559586;Reactome: R-HSA-9018519;Reactome: R-HSA-5693568;Reactome: R-HSA-5693565;Reactome: R-HSA-5693579;Reactome: R-HSA-6804756;Reactome: R-HSA-69473;Reactome: R-HSA-5693616;Reactome: R-HSA-5693554;Reactome: R-HSA-5685942;Reactome: R-HSA-5693571;Reactome: R-HSA-3214847;Reactome: R-HSA-201722;Reactome: R-HSA-5693548	"HDR through Single Strand Annealing (SSA)";"Processing of DNA double-strand break ends";"DNA Damage/Telomere Stress Induced Senescence";"Estrogen-dependent gene expression";"Resolution of D-loop Structures through Holliday Junction Intermediates";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Homologous DNA Pairing and Strand Exchange";"Regulation of TP53 Activity through Phosphorylation";"G2/M DNA damage checkpoint";"Presynaptic phase of homologous DNA pairing and strand exchange";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"HDR through Homologous Recombination (HRR)";"Nonhomologous End-Joining (NHEJ)";"HATs acetylate histones";"Formation of the beta-catenin:TCF transactivating complex";"Sensing of DNA Double Strand Breaks"
Medex_00003370-RA	6	KEGG: 00930+3.1.1.17;MetaCyc: PWY-7165;KEGG: 00053+3.1.1.17;KEGG: 00030+3.1.1.17;MetaCyc: PWY-5530;MetaCyc: PWY-2221	"Caprolactam degradation";"L-ascorbate biosynthesis VI (engineered pathway)";"Ascorbate and aldarate metabolism";"Pentose phosphate pathway";"Sorbitol biosynthesis II";"Entner-Doudoroff pathway III (semi-phosphorylative)"
Medex_00042168-RA	10	Reactome: R-HSA-5628897;Reactome: R-HSA-1445148;Reactome: R-HSA-9619483;Reactome: R-HSA-2151209;Reactome: R-HSA-9613354;Reactome: R-HSA-6804756;Reactome: R-HSA-380972;Reactome: R-HSA-200425;Reactome: R-HSA-163680;Reactome: R-HSA-1632852	"TP53 Regulates Metabolic Genes";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Activation of AMPK downstream of NMDARs";"Activation of PPARGC1A (PGC-1alpha) by phosphorylation";"Lipophagy";"Regulation of TP53 Activity through Phosphorylation";"Energy dependent regulation of mTOR by LKB1-AMPK";"Carnitine metabolism";"AMPK inhibits chREBP transcriptional activation activity";"Macroautophagy"
Medex_00002446-RA	4	Reactome: R-HSA-936440;Reactome: R-HSA-8934903;Reactome: R-HSA-1632852;Reactome: R-HSA-5205685	"Negative regulators of DDX58/IFIH1 signaling";"Receptor Mediated Mitophagy";"Macroautophagy";"Pink/Parkin Mediated Mitophagy"
Medex_00059901-RA	2	Reactome: R-HSA-5654726;Reactome: R-HSA-190373	"Negative regulation of FGFR1 signaling";"FGFR1c ligand binding and activation"
Medex_00077209-RA	7	Reactome: R-HSA-1483148;MetaCyc: PWY-3561;Reactome: R-HSA-1483166;Reactome: R-HSA-2029485;KEGG: 00564+3.1.4.4;KEGG: 00565+3.1.4.4;MetaCyc: PWY-7039	"Synthesis of PG";"Choline biosynthesis III";"Synthesis of PA";"Role of phospholipids in phagocytosis";"Glycerophospholipid metabolism";"Ether lipid metabolism";"Phosphatidate metabolism, as a signaling molecule"
Medex_00062817-RA	3	Reactome: R-HSA-2408508;Reactome: R-HSA-1614603;Reactome: R-HSA-1614558	"Metabolism of ingested SeMet, Sec, MeSec into H2Se";"Cysteine formation from homocysteine";"Degradation of cysteine and homocysteine"
Medex_00051431-RA	26	Reactome: R-HSA-3371497;Reactome: R-HSA-2500257;Reactome: R-HSA-380320;Reactome: R-HSA-1445148;Reactome: R-HSA-389960;Reactome: R-HSA-5663220;Reactome: R-HSA-389977;Reactome: R-HSA-68877;Reactome: R-HSA-9648025;Reactome: R-HSA-6811434;Reactome: R-HSA-9646399;Reactome: R-HSA-5617833;Reactome: R-HSA-2467813;Reactome: R-HSA-2132295;Reactome: R-HSA-5626467;Reactome: R-HSA-9609690;Reactome: R-HSA-6811436;Reactome: R-HSA-8955332;Reactome: R-HSA-6807878;Reactome: R-HSA-190840;Reactome: R-HSA-190861;Reactome: R-HSA-437239;Reactome: R-HSA-9619483;Reactome: R-HSA-8852276;Reactome: R-HSA-9609736;Reactome: R-HSA-983189	"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Resolution of Sister Chromatid Cohesion";"Recruitment of NuMA to mitotic centrosomes";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Formation of tubulin folding intermediates by CCT/TriC";"RHO GTPases Activate Formins";"Post-chaperonin tubulin folding pathway";"Mitotic Prometaphase";"EML4 and NUDC in mitotic spindle formation";"COPI-dependent Golgi-to-ER retrograde traffic";"Aggrephagy";"Cilium Assembly";"Separation of Sister Chromatids";"MHC class II antigen presentation";"RHO GTPases activate IQGAPs";"HCMV Early Events";"COPI-independent Golgi-to-ER retrograde traffic";"Carboxyterminal post-translational modifications of tubulin";"COPI-mediated anterograde transport";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Gap junction assembly";"Recycling pathway of L1";"Activation of AMPK downstream of NMDARs";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Assembly and cell surface presentation of NMDA receptors";"Kinesins"
Medex_00057660-RA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
Medex_00083066-RA	6	Reactome: R-HSA-9639288;Reactome: R-HSA-6798695;Reactome: R-HSA-1222556;Reactome: R-HSA-983712;Reactome: R-HSA-77387;Reactome: R-HSA-917977	"Amino acids regulate mTORC1";"Neutrophil degranulation";"ROS and RNS production in phagocytes";"Ion channel transport";"Insulin receptor recycling";"Transferrin endocytosis and recycling"
Medex_00079895-RA	6	KEGG: 00052+3.2.1.23;KEGG: 00531+3.2.1.23;KEGG: 00604+3.2.1.23;KEGG: 00600+3.2.1.23;KEGG: 00511+3.2.1.23;MetaCyc: PWY-6807	"Galactose metabolism";"Glycosaminoglycan degradation";"Glycosphingolipid biosynthesis - ganglio series";"Sphingolipid metabolism";"Other glycan degradation";"Xyloglucan degradation II (exoglucanase)"
Medex_00040292-RA	1	Reactome: R-HSA-9633012	"Response of EIF2AK4 (GCN2) to amino acid deficiency"
Medex_00012628-RA	6	KEGG: 00531+3.2.1.23;KEGG: 00052+3.2.1.23;MetaCyc: PWY-6807;KEGG: 00511+3.2.1.23;KEGG: 00600+3.2.1.23;KEGG: 00604+3.2.1.23	"Glycosaminoglycan degradation";"Galactose metabolism";"Xyloglucan degradation II (exoglucanase)";"Other glycan degradation";"Sphingolipid metabolism";"Glycosphingolipid biosynthesis - ganglio series"
Medex_00019768-RA	1	Reactome: R-HSA-389661	"Glyoxylate metabolism and glycine degradation"
Medex_00092030-RA	6	Reactome: R-HSA-69052;Reactome: R-HSA-68867;Reactome: R-HSA-68949;Reactome: R-HSA-68962;Reactome: R-HSA-176974;Reactome: R-HSA-176187	"Switching of origins to a post-replicative state";"Assembly of the pre-replicative complex";"Orc1 removal from chromatin";"Activation of the pre-replicative complex";"Unwinding of DNA";"Activation of ATR in response to replication stress"
Medex_00071486-RA	2	Reactome: R-HSA-6798695;Reactome: R-HSA-6811434	"Neutrophil degranulation";"COPI-dependent Golgi-to-ER retrograde traffic"
Medex_00025017-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00033105-RA	3	MetaCyc: PWY-6348;KEGG: 00740+3.1.3.2;KEGG: 00730+3.1.3.2	"Phosphate acquisition";"Riboflavin metabolism";"Thiamine metabolism"
Medex_00020905-RA	7	MetaCyc: PWY-5469;MetaCyc: PWY-6824;MetaCyc: PWY-5461;KEGG: 00940+1.11.1.7;MetaCyc: PWY-7445;MetaCyc: PWY-5466;MetaCyc: PWY-7214	"Sesamin biosynthesis";"Justicidin B biosynthesis";"Betanidin degradation";"Phenylpropanoid biosynthesis";"Luteolin triglucuronide degradation";"Matairesinol biosynthesis";"Baicalein degradation (hydrogen peroxide detoxification)"
Medex_00030519-RA	6	Reactome: R-HSA-6798695;KEGG: 00630+1.11.1.6;Reactome: R-HSA-9033241;KEGG: 00380+1.11.1.6;Reactome: R-HSA-9615017;Reactome: R-HSA-3299685	"Neutrophil degranulation";"Glyoxylate and dicarboxylate metabolism";"Peroxisomal protein import";"Tryptophan metabolism";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"Detoxification of Reactive Oxygen Species"
Medex_00059196-RA	1	Reactome: R-HSA-69273	"Cyclin A/B1/B2 associated events during G2/M transition"
Medex_00081151-RA	5	KEGG: 00515+2.4.1.109;MetaCyc: PWY-7979;KEGG: 00514+2.4.1.109;MetaCyc: PWY-7921;MetaCyc: PWY-7922	"Mannose type O-glycan biosynthesis";"Protein O-mannosylation III (mammals, core M3)";"Other types of O-glycan biosynthesis";"Protein O-mannosylation I (yeast)";"Protein O-mannosylation II (mammals, core M1 and core M2)"
Medex_00005719-RA	7	Reactome: R-HSA-1474151;KEGG: 00670+1.5.1.3;MetaCyc: PWY-3841;KEGG: 00790+1.5.1.3;Reactome: R-HSA-69205;Reactome: R-HSA-196757;MetaCyc: PWY-6614	"Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation";"One carbon pool by folate";"Folate transformations II (plants)";"Folate biosynthesis";"G1/S-Specific Transcription";"Metabolism of folate and pterines";"Tetrahydrofolate biosynthesis"
Medex_00028700-RA	3	Reactome: R-HSA-6787450;MetaCyc: PWY-7887;MetaCyc: PWY-7892	"tRNA modification in the mitochondrion";"Protein SAMPylation and SAMP-mediated thiolation";"Trna-uridine 2-thiolation and selenation (bacteria)"
Medex_00057121-RA	8	KEGG: 00514+2.4.1.109;MetaCyc: PWY-7979;MetaCyc: PWY-7922;Reactome: R-HSA-5083629;Reactome: R-HSA-5173105;Reactome: R-HSA-5083633;KEGG: 00515+2.4.1.109;MetaCyc: PWY-7921	"Other types of O-glycan biosynthesis";"Protein O-mannosylation III (mammals, core M3)";"Protein O-mannosylation II (mammals, core M1 and core M2)";"Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2";"O-linked glycosylation";"Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1";"Mannose type O-glycan biosynthesis";"Protein O-mannosylation I (yeast)"
Medex_00056680-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Medex_00102013-RA	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
Medex_00046113-RA	1	KEGG: 00970+6.1.1.21	"Aminoacyl-tRNA biosynthesis"
Medex_00060470-RA	4	Reactome: R-HSA-1362409;MetaCyc: PWY-7250;KEGG: 00730+2.8.1.7;Reactome: R-HSA-947581	"Mitochondrial iron-sulfur cluster biogenesis";"[2Fe-2S] iron-sulfur cluster biosynthesis";"Thiamine metabolism";"Molybdenum cofactor biosynthesis"
Medex_00085625-RA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
Medex_00075654-RA	29	Reactome: R-HSA-73863;Reactome: R-HSA-73776;Reactome: R-HSA-674695;Reactome: R-HSA-167152;Reactome: R-HSA-6782210;Reactome: R-HSA-73772;Reactome: R-HSA-167172;Reactome: R-HSA-6781823;Reactome: R-HSA-167200;Reactome: R-HSA-167246;Reactome: R-HSA-167160;Reactome: R-HSA-76042;Reactome: R-HSA-6782135;Reactome: R-HSA-167162;Reactome: R-HSA-75955;Reactome: R-HSA-113418;Reactome: R-HSA-73762;Reactome: R-HSA-5696395;Reactome: R-HSA-167158;Reactome: R-HSA-167161;Reactome: R-HSA-75953;Reactome: R-HSA-6781827;Reactome: R-HSA-77075;Reactome: R-HSA-427413;Reactome: R-HSA-73779;Reactome: R-HSA-5696400;Reactome: R-HSA-72086;Reactome: R-HSA-112382;Reactome: R-HSA-6796648	"RNA Polymerase I Transcription Termination";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Pre-transcription Events";"Formation of HIV elongation complex in the absence of HIV Tat";"Gap-filling DNA repair synthesis and ligation in TC-NER";"RNA Polymerase I Promoter Escape";"Transcription of the HIV genome";"Formation of TC-NER Pre-Incision Complex";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Tat-mediated elongation of the HIV-1 transcript";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Dual incision in TC-NER";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Elongation";"Formation of the Early Elongation Complex";"RNA Polymerase I Transcription Initiation";"Formation of Incision Complex in GG-NER";"Formation of the HIV-1 Early Elongation Complex";"HIV Transcription Initiation";"RNA Polymerase II Transcription Initiation";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"RNA Pol II CTD phosphorylation and interaction with CE";"NoRC negatively regulates rRNA expression";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Dual Incision in GG-NER";"mRNA Capping";"Formation of RNA Pol II elongation complex";"TP53 Regulates Transcription of DNA Repair Genes"
Medex_00103275-RA	3	Reactome: R-HSA-212436;Reactome: R-HSA-381340;Reactome: R-HSA-1989781	"Generic Transcription Pathway";"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression"
Medex_00031056-RA	12	Reactome: R-HSA-167290;Reactome: R-HSA-167152;Reactome: R-HSA-674695;Reactome: R-HSA-167287;Reactome: R-HSA-167243;Reactome: R-HSA-6796648;Reactome: R-HSA-167238;Reactome: R-HSA-75955;Reactome: R-HSA-112382;Reactome: R-HSA-6804756;Reactome: R-HSA-167246;Reactome: R-HSA-167200	"Pausing and recovery of HIV elongation";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Polymerase II Pre-transcription Events";"HIV elongation arrest and recovery";"Tat-mediated HIV elongation arrest and recovery";"TP53 Regulates Transcription of DNA Repair Genes";"Pausing and recovery of Tat-mediated HIV elongation";"RNA Polymerase II Transcription Elongation";"Formation of RNA Pol II elongation complex";"Regulation of TP53 Activity through Phosphorylation";"Tat-mediated elongation of the HIV-1 transcript";"Formation of HIV-1 elongation complex containing HIV-1 Tat"
Medex_00019370-RA	3	Reactome: R-HSA-674695;Reactome: R-HSA-75955;Reactome: R-HSA-112382	"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Elongation";"Formation of RNA Pol II elongation complex"
Medex_00022244-RA	2	KEGG: 00520+5.4.2.10;MetaCyc: PWY-6749	"Amino sugar and nucleotide sugar metabolism";"CMP-legionaminate biosynthesis I"
Medex_00051283-RA	4	Reactome: R-HSA-3928662;Reactome: R-HSA-5663213;Reactome: R-HSA-8856828;Reactome: R-HSA-2029482	"EPHB-mediated forward signaling";"RHO GTPases Activate WASPs and WAVEs";"Clathrin-mediated endocytosis";"Regulation of actin dynamics for phagocytic cup formation"
Medex_00009169-RA	22	MetaCyc: PWY-5659;MetaCyc: PWY-5054;Reactome: R-HSA-70171;Reactome: R-HSA-70263;MetaCyc: PWY-7238;MetaCyc: PWY-5384;KEGG: 00030+5.3.1.9;MetaCyc: PWY-7347;MetaCyc: PWY-7385;KEGG: 00520+5.3.1.9;MetaCyc: PWY-6981;MetaCyc: PWY-6992;MetaCyc: PWY-622;KEGG: 00500+5.3.1.9;MetaCyc: PWY-6142;MetaCyc: PWY-621;MetaCyc: PWY-3801;KEGG: 00010+5.3.1.9;Reactome: R-HSA-6798695;Reactome: R-HSA-5628897;MetaCyc: PWY-5514;MetaCyc: PWY-8013	"GDP-mannose biosynthesis";"D-sorbitol biosynthesis I";"Glycolysis";"Gluconeogenesis";"Sucrose biosynthesis II";"Sucrose degradation IV (sucrose phosphorylase)";"Pentose phosphate pathway";"Sucrose biosynthesis III";"1,3-propanediol biosynthesis (engineered)";"Amino sugar and nucleotide sugar metabolism";"Chitin biosynthesis";"1,5-anhydrofructose degradation";"Starch biosynthesis";"Starch and sucrose metabolism";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Sucrose degradation III (sucrose invertase)";"Sucrose degradation II (sucrose synthase)";"Glycolysis / Gluconeogenesis";"Neutrophil degranulation";"TP53 Regulates Metabolic Genes";"UDP-N-acetyl-D-galactosamine biosynthesis II";"UDP-N-acetyl-D-galactosamine biosynthesis III"
Medex_00082085-RA	11	Reactome: R-HSA-380320;Reactome: R-HSA-8854518;Reactome: R-HSA-2565942;Reactome: R-HSA-2132295;Reactome: R-HSA-3371497;Reactome: R-HSA-6807878;Reactome: R-HSA-6811436;Reactome: R-HSA-5620912;Reactome: R-HSA-380270;Reactome: R-HSA-380259;Reactome: R-HSA-380284	"Recruitment of NuMA to mitotic centrosomes";"AURKA Activation by TPX2";"Regulation of PLK1 Activity at G2/M Transition";"MHC class II antigen presentation";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-mediated anterograde transport";"COPI-independent Golgi-to-ER retrograde traffic";"Anchoring of the basal body to the plasma membrane";"Recruitment of mitotic centrosome proteins and complexes";"Loss of Nlp from mitotic centrosomes";"Loss of proteins required for interphase microtubule organization from the centrosome"
Medex_00065093-RA	3	Reactome: R-HSA-5358493;MetaCyc: PWY-6482;MetaCyc: PWY-7546	"Synthesis of diphthamide-EEF2";"Diphthamide biosynthesis I (archaea)";"Diphthamide biosynthesis II (eukaryotes)"
Medex_00003008-RA	10	Reactome: R-HSA-6807505;Reactome: R-HSA-674695;Reactome: R-HSA-73776;Reactome: R-HSA-167161;Reactome: R-HSA-75953;Reactome: R-HSA-167172;Reactome: R-HSA-9018519;Reactome: R-HSA-167162;Reactome: R-HSA-76042;Reactome: R-HSA-73779	"RNA polymerase II transcribes snRNA genes";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Promoter Escape";"HIV Transcription Initiation";"RNA Polymerase II Transcription Initiation";"Transcription of the HIV genome";"Estrogen-dependent gene expression";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"
Medex_00084695-RA	12	Reactome: R-HSA-2644606;Reactome: R-HSA-3928665;Reactome: R-HSA-2979096;Reactome: R-HSA-9013700;Reactome: R-HSA-193692;Reactome: R-HSA-205043;Reactome: R-HSA-977225;Reactome: R-HSA-9013507;Reactome: R-HSA-2122948;Reactome: R-HSA-9017802;Reactome: R-HSA-2894862;Reactome: R-HSA-1251985	"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"EPH-ephrin mediated repulsion of cells";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"NOTCH4 Activation and Transmission of Signal to the Nucleus";"Regulated proteolysis of p75NTR";"NRIF signals cell death from the nucleus";"Amyloid fiber formation";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Activated NOTCH1 Transmits Signal to the Nucleus";"Noncanonical activation of NOTCH3";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Nuclear signaling by ERBB4"
Medex_00003152-RA	2	KEGG: 00970+2.1.2.9;KEGG: 00670+2.1.2.9	"Aminoacyl-tRNA biosynthesis";"One carbon pool by folate"
Medex_00032534-RA	7	KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1	"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Human cytomegalovirus infection";"Relaxin signaling pathway";"Thermogenesis"
Medex_00094912-RA	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
Medex_00078356-RA	14	MetaCyc: PWY-7587;MetaCyc: PWY-5981;MetaCyc: PWY-7782;KEGG: 00561+2.3.1.51;KEGG: 00564+2.3.1.51;MetaCyc: PWY-7411;MetaCyc: PWY-8055;MetaCyc: PWY-5667;MetaCyc: PWY-8051;MetaCyc: PWY-6453;Reactome: R-HSA-1483166;MetaCyc: PWY-7417;MetaCyc: PWY-8053;MetaCyc: PWY-7589	"Oleate biosynthesis III (cyanobacteria)";"CDP-diacylglycerol biosynthesis III";"Plasmalogen biosynthesis";"Glycerolipid metabolism";"Glycerophospholipid metabolism";"Phosphatidate biosynthesis (yeast)";"Palmitoyl ethanolamide biosynthesis";"CDP-diacylglycerol biosynthesis I";"Anandamide biosynthesis I";"Stigma estolide biosynthesis";"Synthesis of PA";"Phospholipid remodeling (phosphatidate, yeast)";"Anandamide biosynthesis II";"Palmitoleate biosynthesis III (cyanobacteria)"
Medex_00075556-RA	2	KEGG: 00670+2.1.2.9;KEGG: 00970+2.1.2.9	"One carbon pool by folate";"Aminoacyl-tRNA biosynthesis"
Medex_00028872-RA	1	Reactome: R-HSA-429947	"Deadenylation of mRNA"
Medex_00012535-RA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
Medex_00035488-RA	1	Reactome: R-HSA-6784531	"tRNA processing in the nucleus"
Medex_00070096-RA	2	KEGG: 00270+3.3.1.1;MetaCyc: PWY-5041	"Cysteine and methionine metabolism";"S-adenosyl-L-methionine cycle II"
Medex_00049204-RA	13	Reactome: R-HSA-6791226;Reactome: R-HSA-2408557;Reactome: R-HSA-72764;Reactome: R-HSA-72689;Reactome: R-HSA-975956;Reactome: R-HSA-72706;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-156902;Reactome: R-HSA-9633012;Reactome: R-HSA-1799339;Reactome: R-HSA-192823;Reactome: R-HSA-975957	"Major pathway of rRNA processing in the nucleolus and cytosol";"Selenocysteine synthesis";"Eukaryotic Translation Termination";"Formation of a pool of free 40S subunits";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Peptide chain elongation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"SRP-dependent cotranslational protein targeting to membrane";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
Medex_00073338-RA	1	Reactome: R-HSA-6802952	"Signaling by BRAF and RAF fusions"
Medex_00014138-RA	3	Reactome: R-HSA-3214847;Reactome: R-HSA-201722;Reactome: R-HSA-5689880	"HATs acetylate histones";"Formation of the beta-catenin:TCF transactivating complex";"Ub-specific processing proteases"
Medex_00052899-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00008789-RA	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
Medex_00023689-RA	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
Medex_00055212-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Medex_00028138-RA	10	MetaCyc: PWY-1042;Reactome: R-HSA-70171;KEGG: 00052+2.7.1.11;KEGG: 00680+2.7.1.11;MetaCyc: PWY-1861;MetaCyc: PWY-5484;KEGG: 00030+2.7.1.11;KEGG: 00051+2.7.1.11;KEGG: 00010+2.7.1.11;MetaCyc: PWY-7385	"Glycolysis IV (plant cytosol)";"Glycolysis";"Galactose metabolism";"Methane metabolism";"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"Glycolysis II (from fructose 6-phosphate)";"Pentose phosphate pathway";"Fructose and mannose metabolism";"Glycolysis / Gluconeogenesis";"1,3-propanediol biosynthesis (engineered)"
Medex_00009519-RA	4	Reactome: R-HSA-400511;Reactome: R-HSA-381771;Reactome: R-HSA-422085;Reactome: R-HSA-1799339	"Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)";"Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)";"Synthesis, secretion, and deacylation of Ghrelin";"SRP-dependent cotranslational protein targeting to membrane"
Medex_00019197-RA	3	Reactome: R-HSA-1614603;Reactome: R-HSA-2408508;Reactome: R-HSA-1614558	"Cysteine formation from homocysteine";"Metabolism of ingested SeMet, Sec, MeSec into H2Se";"Degradation of cysteine and homocysteine"
Medex_00050027-RA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00081230-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Medex_00072847-RA	2	Reactome: R-HSA-390471;Reactome: R-HSA-1660662	"Association of TriC/CCT with target proteins during biosynthesis";"Glycosphingolipid metabolism"
Medex_00068625-RA	1	Reactome: R-HSA-3238698	"WNT ligand biogenesis and trafficking"
Medex_00000066-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Medex_00085234-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00064723-RA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
Medex_00040972-RA	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
Medex_00051730-RA	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
Medex_00000059-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Medex_00065239-RA	3	Reactome: R-HSA-156590;KEGG: 00680+3.1.2.12;MetaCyc: PWY-1801	"Glutathione conjugation";"Methane metabolism";"Formaldehyde oxidation II (glutathione-dependent)"
Medex_00003732-RA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
Medex_00046817-RA	2	Reactome: R-HSA-390471;Reactome: R-HSA-1660662	"Association of TriC/CCT with target proteins during biosynthesis";"Glycosphingolipid metabolism"
Medex_00066569-RA	1	Reactome: R-HSA-5620922	"BBSome-mediated cargo-targeting to cilium"
Medex_00000070-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Medex_00082506-RA	2	KEGG: 00480+1.11.1.15;Reactome: R-HSA-3299685	"Glutathione metabolism";"Detoxification of Reactive Oxygen Species"
Medex_00065347-RA	1	Reactome: R-HSA-6811434	"COPI-dependent Golgi-to-ER retrograde traffic"
Medex_00031456-RA	1	Reactome: R-HSA-162791	"Attachment of GPI anchor to uPAR"
Medex_00023527-RA	4	KEGG: 00514+2.4.1.255;MetaCyc: PWY-7437;Reactome: R-HSA-5689603;Reactome: R-HSA-3214847	"Other types of O-glycan biosynthesis";"Protein O-[N-acetyl]-glucosylation";"UCH proteinases";"HATs acetylate histones"
Medex_00062104-RA	56	Reactome: R-HSA-2467813;Reactome: R-HSA-4641258;Reactome: R-HSA-450408;Reactome: R-HSA-180585;Reactome: R-HSA-68949;Reactome: R-HSA-8939236;Reactome: R-HSA-382556;Reactome: R-HSA-211733;Reactome: R-HSA-9010553;Reactome: R-HSA-8941858;Reactome: R-HSA-5358346;Reactome: R-HSA-5658442;Reactome: R-HSA-202424;Reactome: R-HSA-983168;Reactome: R-HSA-9020702;Reactome: R-HSA-5632684;Reactome: R-HSA-180534;Reactome: R-HSA-349425;Reactome: R-HSA-1236978;Reactome: R-HSA-8852276;Reactome: R-HSA-5610780;Reactome: R-HSA-5607761;Reactome: R-HSA-174178;Reactome: R-HSA-75815;Reactome: R-HSA-8939902;Reactome: R-HSA-195253;Reactome: R-HSA-5610785;Reactome: R-HSA-5689880;Reactome: R-HSA-4608870;Reactome: R-HSA-5687128;Reactome: R-HSA-5689603;Reactome: R-HSA-5668541;Reactome: R-HSA-5610783;Reactome: R-HSA-8854050;Reactome: R-HSA-1236974;Reactome: R-HSA-174084;Reactome: R-HSA-187577;Reactome: R-HSA-174154;Reactome: R-HSA-1169091;Reactome: R-HSA-174184;Reactome: R-HSA-5607764;Reactome: R-HSA-2871837;Reactome: R-HSA-8951664;Reactome: R-HSA-69481;Reactome: R-HSA-5678895;Reactome: R-HSA-350562;Reactome: R-HSA-4641257;Reactome: R-HSA-174113;Reactome: R-HSA-5676590;Reactome: R-HSA-5362768;Reactome: R-HSA-69601;Reactome: R-HSA-1234176;Reactome: R-HSA-69017;Reactome: R-HSA-8948751;Reactome: R-HSA-9604323;Reactome: R-HSA-68827	"Separation of Sister Chromatids";"Degradation of DVL";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Vif-mediated degradation of APOBEC3G";"Orc1 removal from chromatin";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"ABC-family proteins mediated transport";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Regulation of expression of SLITs and ROBOs";"Regulation of RUNX3 expression and activity";"Hedgehog ligand biogenesis";"Regulation of RAS by GAPs";"Downstream TCR signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Interleukin-1 signaling";"Hedgehog 'on' state";"Vpu mediated degradation of CD4";"Autodegradation of the E3 ubiquitin ligase COP1";"Cross-presentation of soluble exogenous antigens (endosomes)";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Degradation of GLI1 by the proteasome";"Dectin-1 mediated noncanonical NF-kB signaling";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Ubiquitin-dependent degradation of Cyclin D";"Regulation of RUNX2 expression and activity";"Degradation of beta-catenin by the destruction complex";"GLI3 is processed to GLI3R by the proteasome";"Ub-specific processing proteases";"Asymmetric localization of PCP proteins";"MAPK6/MAPK4 signaling";"UCH proteinases";"TNFR2 non-canonical NF-kB pathway";"Degradation of GLI2 by the proteasome";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"ER-Phagosome pathway";"Autodegradation of Cdh1 by Cdh1:APC/C";"SCF(Skp2)-mediated degradation of p27/p21";"APC/C:Cdc20 mediated degradation of Securin";"Activation of NF-kappaB in B cells";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"CLEC7A (Dectin-1) signaling";"FCERI mediated NF-kB activation";"Neddylation";"G2/M Checkpoints";"Defective CFTR causes cystic fibrosis";"Regulation of ornithine decarboxylase (ODC)";"Degradation of AXIN";"SCF-beta-TrCP mediated degradation of Emi1";"NIK-->noncanonical NF-kB signaling";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"CDK-mediated phosphorylation and removal of Cdc6";"Regulation of PTEN stability and activity";"Negative regulation of NOTCH4 signaling";"CDT1 association with the CDC6:ORC:origin complex"
Medex_00028435-RA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00086896-RA	1	Reactome: R-HSA-6803157	"Antimicrobial peptides"
Medex_00099743-RA	2	Reactome: R-HSA-72163;Reactome: R-HSA-430039	"mRNA Splicing - Major Pathway";"mRNA decay by 5' to 3' exoribonuclease"
Medex_00021568-RA	5	Reactome: R-HSA-204005;Reactome: R-HSA-2132295;Reactome: R-HSA-5694530;Reactome: R-HSA-1655829;Reactome: R-HSA-983170	"COPII-mediated vesicle transport";"MHC class II antigen presentation";"Cargo concentration in the ER";"Regulation of cholesterol biosynthesis by SREBP (SREBF)";"Antigen Presentation: Folding, assembly and peptide loading of class I MHC"
Medex_00067989-RA	3	Reactome: R-HSA-8876198;Reactome: R-HSA-6811440;Reactome: R-HSA-6811438	"RAB GEFs exchange GTP for GDP on RABs";"Retrograde transport at the Trans-Golgi-Network";"Intra-Golgi traffic"
Medex_00050836-RA	6	Reactome: R-HSA-9640463;MetaCyc: PWY-5884;KEGG: 00073+1.2.1.84;MetaCyc: PWY-7782;MetaCyc: PWY-7656;MetaCyc: PWY-6733	"Wax biosynthesis";"Wax esters biosynthesis I";"Cutin, suberine and wax biosynthesis";"Plasmalogen biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Sporopollenin precursors biosynthesis"
Medex_00055551-RA	3	KEGG: 00970+6.1.1.4;Reactome: R-HSA-379716;Reactome: R-HSA-2408522	"Aminoacyl-tRNA biosynthesis";"Cytosolic tRNA aminoacylation";"Selenoamino acid metabolism"
Medex_00033788-RA	3	Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-212436	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"Generic Transcription Pathway"
Medex_00001728-RA	2	Reactome: R-HSA-3299685;MetaCyc: PWY-6854	"Detoxification of Reactive Oxygen Species";"Ethylene biosynthesis III (microbes)"
Medex_00061799-RA	1	Reactome: R-HSA-8951664	"Neddylation"
Medex_00023000-RA	2	Reactome: R-HSA-6807878;Reactome: R-HSA-445095	"COPI-mediated anterograde transport";"Interaction between L1 and Ankyrins"
Medex_00052274-RA	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
Medex_00010877-RA	7	Reactome: R-HSA-69205;Reactome: R-HSA-69656;Reactome: R-HSA-1362300;Reactome: R-HSA-1362277;Reactome: R-HSA-69202;Reactome: R-HSA-1538133;Reactome: R-HSA-156711	"G1/S-Specific Transcription";"Cyclin A:Cdk2-associated events at S phase entry";"Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1";"Transcription of E2F targets under negative control by DREAM complex";"Cyclin E associated events during G1/S transition";"G0 and Early G1";"Polo-like kinase mediated events"
Medex_00019627-RA	4	Reactome: R-HSA-499943;MetaCyc: PWY-7219;KEGG: 00230+2.7.4.3;KEGG: 00730+2.7.4.3	"Interconversion of nucleotide di- and triphosphates";"Adenosine ribonucleotides de novo biosynthesis";"Purine metabolism";"Thiamine metabolism"
Medex_00034910-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Medex_00007114-RA	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
Medex_00012903-RA	1	Reactome: R-HSA-389661	"Glyoxylate metabolism and glycine degradation"
Medex_00009881-RA	7	MetaCyc: PWY-6545;KEGG: 00230+3.6.1.15;MetaCyc: PWY-7210;MetaCyc: PWY-7198;KEGG: 00730+3.6.1.15;MetaCyc: PWY-7184;MetaCyc: PWY-7185	"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Purine metabolism";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Thiamine metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"UTP and CTP dephosphorylation I"
Medex_00034114-RA	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
Medex_00082539-RA	13	Reactome: R-HSA-975957;Reactome: R-HSA-192823;Reactome: R-HSA-1799339;Reactome: R-HSA-156902;Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-72706;Reactome: R-HSA-975956;Reactome: R-HSA-72764;Reactome: R-HSA-72689;Reactome: R-HSA-2408557;Reactome: R-HSA-6791226	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Viral mRNA Translation";"SRP-dependent cotranslational protein targeting to membrane";"Peptide chain elongation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Formation of a pool of free 40S subunits";"Selenocysteine synthesis";"Major pathway of rRNA processing in the nucleolus and cytosol"
Medex_00041231-RA	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
Medex_00068658-RA	1	Reactome: R-HSA-6794361	"Neurexins and neuroligins"
Medex_00047474-RA	1	Reactome: R-HSA-426486	"Small interfering RNA (siRNA) biogenesis"
Medex_00036715-RA	1	Reactome: R-HSA-2132295	"MHC class II antigen presentation"
Medex_00011335-RA	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
Medex_00033031-RA	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
Medex_00046770-RA	1	Reactome: R-HSA-400253	"Circadian Clock"
Medex_00025394-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00087066-RA	6	KEGG: 00531+3.2.1.23;KEGG: 00052+3.2.1.23;KEGG: 00604+3.2.1.23;KEGG: 00600+3.2.1.23;KEGG: 00511+3.2.1.23;MetaCyc: PWY-6807	"Glycosaminoglycan degradation";"Galactose metabolism";"Glycosphingolipid biosynthesis - ganglio series";"Sphingolipid metabolism";"Other glycan degradation";"Xyloglucan degradation II (exoglucanase)"
Medex_00091093-RA	3	KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16	"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
Medex_00035550-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00020376-RA	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
Medex_00015895-RA	1	Reactome: R-HSA-2132295	"MHC class II antigen presentation"
Medex_00028989-RA	9	Reactome: R-HSA-5696400;Reactome: R-HSA-6782135;Reactome: R-HSA-110314;Reactome: R-HSA-5696394;Reactome: R-HSA-6782210;Reactome: R-HSA-6781823;Reactome: R-HSA-5696395;Reactome: R-HSA-6781827;Reactome: R-HSA-8951664	"Dual Incision in GG-NER";"Dual incision in TC-NER";"Recognition of DNA damage by PCNA-containing replication complex";"DNA Damage Recognition in GG-NER";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Formation of TC-NER Pre-Incision Complex";"Formation of Incision Complex in GG-NER";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Neddylation"
Medex_00058384-RA	1	Reactome: R-HSA-5689880	"Ub-specific processing proteases"
Medex_00087994-RA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
Medex_00016427-RA	5	MetaCyc: PWY-7919;KEGG: 00510+3.2.1.106;Reactome: R-HSA-4793954;Reactome: R-HSA-532668;MetaCyc: PWY-7918	"Protein N-glycosylation processing phase (plants and animals)";"N-Glycan biosynthesis";"Defective MOGS causes MOGS-CDG (CDG-2b)";"N-glycan trimming in the ER and Calnexin/Calreticulin cycle";"Protein N-glycosylation processing phase (yeast)"
Medex_00021552-RA	4	KEGG: 00480+2.5.1.22;Reactome: R-HSA-351202;KEGG: 00330+2.5.1.22;KEGG: 00270+2.5.1.22	"Glutathione metabolism";"Metabolism of polyamines";"Arginine and proline metabolism";"Cysteine and methionine metabolism"
Medex_00015505-RA	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840	"Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation"
Medex_00043115-RA	1	KEGG: 00760+2.3.1.286	"Nicotinate and nicotinamide metabolism"
Medex_00043818-RA	3	Reactome: R-HSA-1483213;MetaCyc: PWY-5669;KEGG: 00564+4.1.1.65	"Synthesis of PE";"Phosphatidylserine and phosphatidylethanolamine biosynthesis I";"Glycerophospholipid metabolism"
Medex_00082219-RA	1	Reactome: R-HSA-1614558	"Degradation of cysteine and homocysteine"
Medex_00039185-RA	7	MetaCyc: PWY-5514;KEGG: 00030+3.1.1.31;Reactome: R-HSA-71336;MetaCyc: PWY-8004;KEGG: 00520+3.5.99.6;MetaCyc: PWY-6906;MetaCyc: PWY-6855	"UDP-N-acetyl-D-galactosamine biosynthesis II";"Pentose phosphate pathway";"Pentose phosphate pathway";"Entner-Doudoroff pathway I";"Amino sugar and nucleotide sugar metabolism";"Chitin derivatives degradation";"Chitin degradation I (archaea)"
Medex_00064016-RA	2	MetaCyc: PWY-6854;Reactome: R-HSA-3299685	"Ethylene biosynthesis III (microbes)";"Detoxification of Reactive Oxygen Species"
Medex_00038398-RA	3	KEGG: 00540+2.7.7.38;MetaCyc: PWY-1269;Reactome: R-HSA-4085001	"Lipopolysaccharide biosynthesis";"CMP-3-deoxy-D-manno-octulosonate biosynthesis";"Sialic acid metabolism"
Medex_00088947-RA	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
Medex_00015796-RA	1	Reactome: R-HSA-70895	"Branched-chain amino acid catabolism"
Medex_00017383-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Medex_00023042-RA	2	KEGG: 00970+6.1.1.20;Reactome: R-HSA-379726	"Aminoacyl-tRNA biosynthesis";"Mitochondrial tRNA aminoacylation"
Medex_00053179-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00087917-RA	58	Reactome: R-HSA-2467813;Reactome: R-HSA-4641258;Reactome: R-HSA-450408;Reactome: R-HSA-5689901;Reactome: R-HSA-180585;Reactome: R-HSA-68949;Reactome: R-HSA-382556;Reactome: R-HSA-8939236;Reactome: R-HSA-211733;Reactome: R-HSA-9010553;Reactome: R-HSA-5358346;Reactome: R-HSA-8941858;Reactome: R-HSA-5658442;Reactome: R-HSA-202424;Reactome: R-HSA-983168;Reactome: R-HSA-9020702;Reactome: R-HSA-6798695;Reactome: R-HSA-5632684;Reactome: R-HSA-180534;Reactome: R-HSA-349425;Reactome: R-HSA-1236978;Reactome: R-HSA-5610780;Reactome: R-HSA-8852276;Reactome: R-HSA-5607761;Reactome: R-HSA-174178;Reactome: R-HSA-75815;Reactome: R-HSA-8939902;Reactome: R-HSA-195253;Reactome: R-HSA-5610785;Reactome: R-HSA-5689880;Reactome: R-HSA-4608870;Reactome: R-HSA-5668541;Reactome: R-HSA-5687128;Reactome: R-HSA-5689603;Reactome: R-HSA-5610783;Reactome: R-HSA-8854050;Reactome: R-HSA-1236974;Reactome: R-HSA-174084;Reactome: R-HSA-187577;Reactome: R-HSA-174154;Reactome: R-HSA-1169091;Reactome: R-HSA-174184;Reactome: R-HSA-5607764;Reactome: R-HSA-2871837;Reactome: R-HSA-8951664;Reactome: R-HSA-350562;Reactome: R-HSA-5678895;Reactome: R-HSA-69481;Reactome: R-HSA-4641257;Reactome: R-HSA-174113;Reactome: R-HSA-5676590;Reactome: R-HSA-69601;Reactome: R-HSA-1234176;Reactome: R-HSA-69017;Reactome: R-HSA-5362768;Reactome: R-HSA-9604323;Reactome: R-HSA-8948751;Reactome: R-HSA-68827	"Separation of Sister Chromatids";"Degradation of DVL";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Metalloprotease DUBs";"Vif-mediated degradation of APOBEC3G";"Orc1 removal from chromatin";"ABC-family proteins mediated transport";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Regulation of expression of SLITs and ROBOs";"Hedgehog ligand biogenesis";"Regulation of RUNX3 expression and activity";"Regulation of RAS by GAPs";"Downstream TCR signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Interleukin-1 signaling";"Neutrophil degranulation";"Hedgehog 'on' state";"Vpu mediated degradation of CD4";"Autodegradation of the E3 ubiquitin ligase COP1";"Cross-presentation of soluble exogenous antigens (endosomes)";"Degradation of GLI1 by the proteasome";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Dectin-1 mediated noncanonical NF-kB signaling";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Ubiquitin-dependent degradation of Cyclin D";"Regulation of RUNX2 expression and activity";"Degradation of beta-catenin by the destruction complex";"GLI3 is processed to GLI3R by the proteasome";"Ub-specific processing proteases";"Asymmetric localization of PCP proteins";"TNFR2 non-canonical NF-kB pathway";"MAPK6/MAPK4 signaling";"UCH proteinases";"Degradation of GLI2 by the proteasome";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"ER-Phagosome pathway";"Autodegradation of Cdh1 by Cdh1:APC/C";"SCF(Skp2)-mediated degradation of p27/p21";"APC/C:Cdc20 mediated degradation of Securin";"Activation of NF-kappaB in B cells";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"CLEC7A (Dectin-1) signaling";"FCERI mediated NF-kB activation";"Neddylation";"Regulation of ornithine decarboxylase (ODC)";"Defective CFTR causes cystic fibrosis";"G2/M Checkpoints";"Degradation of AXIN";"SCF-beta-TrCP mediated degradation of Emi1";"NIK-->noncanonical NF-kB signaling";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"CDK-mediated phosphorylation and removal of Cdc6";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Negative regulation of NOTCH4 signaling";"Regulation of PTEN stability and activity";"CDT1 association with the CDC6:ORC:origin complex"
Medex_00022489-RA	2	Reactome: R-HSA-611105;Reactome: R-HSA-5628897	"Respiratory electron transport";"TP53 Regulates Metabolic Genes"
Medex_00065112-RA	1	Reactome: R-HSA-8949664	"Processing of SMDT1"
Medex_00015576-RA	2	Reactome: R-HSA-8983711;Reactome: R-HSA-909733	"OAS antiviral response";"Interferon alpha/beta signaling"
Medex_00064025-RA	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
Medex_00031665-RA	1	Reactome: R-HSA-2022377	"Metabolism of Angiotensinogen to Angiotensins"
Medex_00072710-RA	2	Reactome: R-HSA-189085;Reactome: R-HSA-390522	"Digestion of dietary carbohydrate";"Striated Muscle Contraction"
Medex_00101292-RA	42	Reactome: R-HSA-2559580;Reactome: R-HSA-110329;Reactome: R-HSA-171306;Reactome: R-HSA-212300;Reactome: R-HSA-5250924;Reactome: R-HSA-606279;Reactome: R-HSA-110331;Reactome: R-HSA-1221632;Reactome: R-HSA-5617472;Reactome: R-HSA-2559586;Reactome: R-HSA-9018519;Reactome: R-HSA-3214841;Reactome: R-HSA-3214858;Reactome: R-HSA-427389;Reactome: R-HSA-5578749;Reactome: R-HSA-2559582;Reactome: R-HSA-110328;Reactome: R-HSA-2299718;Reactome: R-HSA-9609690;Reactome: R-HSA-1912408;Reactome: R-HSA-5693571;Reactome: R-HSA-9610379;Reactome: R-HSA-977225;Reactome: R-HSA-427359;Reactome: R-HSA-5334118;Reactome: R-HSA-73728;Reactome: R-HSA-73772;Reactome: R-HSA-5693607;Reactome: R-HSA-8939236;Reactome: R-HSA-3214815;Reactome: R-HSA-110330;Reactome: R-HSA-5693565;Reactome: R-HSA-8936459;Reactome: R-HSA-5625886;Reactome: R-HSA-3214842;Reactome: R-HSA-69473;Reactome: R-HSA-912446;Reactome: R-HSA-4551638;Reactome: R-HSA-9616222;Reactome: R-HSA-201722;Reactome: R-HSA-427413;Reactome: R-HSA-3214847	"Oxidative Stress Induced Senescence";"Cleavage of the damaged pyrimidine";"Packaging Of Telomere Ends";"PRC2 methylates histones and DNA";"B-WICH complex positively regulates rRNA expression";"Deposition of new CENPA-containing nucleosomes at the centromere";"Cleavage of the damaged purine";"Meiotic synapsis";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"DNA Damage/Telomere Stress Induced Senescence";"Estrogen-dependent gene expression";"PKMTs methylate histone lysines";"RMTs methylate histone arginines";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"Transcriptional regulation by small RNAs";"Senescence-Associated Secretory Phenotype (SASP)";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"Condensation of Prophase Chromosomes";"HCMV Early Events";"Pre-NOTCH Transcription and Translation";"Nonhomologous End-Joining (NHEJ)";"HCMV Late Events";"Amyloid fiber formation";"SIRT1 negatively regulates rRNA expression";"DNA methylation";"RNA Polymerase I Promoter Opening";"RNA Polymerase I Promoter Escape";"Processing of DNA double-strand break ends";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"HDACs deacetylate histones";"Recognition and association of DNA glycosylase with site containing an affected purine";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3";"HDMs demethylate histones";"G2/M DNA damage checkpoint";"Meiotic recombination";"SUMOylation of chromatin organization proteins";"Transcriptional regulation of granulopoiesis";"Formation of the beta-catenin:TCF transactivating complex";"NoRC negatively regulates rRNA expression";"HATs acetylate histones"
Medex_00025108-RA	29	KEGG: 04714+2.7.11.1;Reactome: R-HSA-6803207;KEGG: 04150+2.7.11.1;Reactome: R-HSA-5685938;Reactome: R-HSA-5693607;Reactome: R-HSA-6804760;Reactome: R-HSA-2559586;Reactome: R-HSA-3371453;Reactome: R-HSA-5693565;Reactome: R-HSA-6803204;KEGG: 05163+2.7.11.1;Reactome: R-HSA-5693568;Reactome: R-HSA-69541;KEGG: 04151+2.7.11.1;Reactome: R-HSA-5693579;Reactome: R-HSA-6804756;Reactome: R-HSA-69473;Reactome: R-HSA-5693616;Reactome: R-HSA-349425;Reactome: R-HSA-5693554;Reactome: R-HSA-912446;Reactome: R-HSA-5685942;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;Reactome: R-HSA-5693571;Reactome: R-HSA-6804757;Reactome: R-HSA-6796648;Reactome: R-HSA-5693548	"Thermogenesis";"TP53 Regulates Transcription of Caspase Activators and Caspases";"mTOR signaling pathway";"HDR through Single Strand Annealing (SSA)";"Processing of DNA double-strand break ends";"Regulation of TP53 Activity through Methylation";"DNA Damage/Telomere Stress Induced Senescence";"Regulation of HSF1-mediated heat shock response";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"TP53 Regulates Transcription of Genes Involved in Cytochrome C Release";"Human cytomegalovirus infection";"Resolution of D-loop Structures through Holliday Junction Intermediates";"Stabilization of p53";"PI3K-Akt signaling pathway";"Homologous DNA Pairing and Strand Exchange";"Regulation of TP53 Activity through Phosphorylation";"G2/M DNA damage checkpoint";"Presynaptic phase of homologous DNA pairing and strand exchange";"Autodegradation of the E3 ubiquitin ligase COP1";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Meiotic recombination";"HDR through Homologous Recombination (HRR)";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Relaxin signaling pathway";"Nonhomologous End-Joining (NHEJ)";"Regulation of TP53 Degradation";"TP53 Regulates Transcription of DNA Repair Genes";"Sensing of DNA Double Strand Breaks"
Medex_00053754-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00000007-RA	5	Reactome: R-HSA-4085001;Reactome: R-HSA-1660662;Reactome: R-HSA-4341670;Reactome: R-HSA-6798695;Reactome: R-HSA-2132295	"Sialic acid metabolism";"Glycosphingolipid metabolism";"Defective NEU1 causes sialidosis";"Neutrophil degranulation";"MHC class II antigen presentation"
Medex_00073201-RA	1	Reactome: R-HSA-70221	"Glycogen breakdown (glycogenolysis)"
Medex_00078599-RA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Medex_00035152-RA	7	Reactome: R-HSA-76066;Reactome: R-HSA-73780;Reactome: R-HSA-749476;Reactome: R-HSA-76061;Reactome: R-HSA-1834949;Reactome: R-HSA-76071;Reactome: R-HSA-73980	"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Chain Elongation";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Transcription Termination"
Medex_00008497-RA	6	MetaCyc: PWY-7782;MetaCyc: PWY-6733;MetaCyc: PWY-7656;KEGG: 00073+1.2.1.84;MetaCyc: PWY-5884;Reactome: R-HSA-9640463	"Plasmalogen biosynthesis";"Sporopollenin precursors biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax esters biosynthesis I";"Wax biosynthesis"
Medex_00022465-RA	4	Reactome: R-HSA-6782210;Reactome: R-HSA-6782135;Reactome: R-HSA-6781823;Reactome: R-HSA-6781827	"Gap-filling DNA repair synthesis and ligation in TC-NER";"Dual incision in TC-NER";"Formation of TC-NER Pre-Incision Complex";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)"
Medex_00040940-RA	1	Reactome: R-HSA-425986	"Sodium/Proton exchangers"
Medex_00069180-RA	1	KEGG: 00480+3.4.11.2	"Glutathione metabolism"
Medex_00088039-RA	6	Reactome: R-HSA-5358565;Reactome: R-HSA-5632928;Reactome: R-HSA-5358606;Reactome: R-HSA-6796648;Reactome: R-HSA-5632927;Reactome: R-HSA-5632968	"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"Defective Mismatch Repair Associated With MSH2";"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"TP53 Regulates Transcription of DNA Repair Genes";"Defective Mismatch Repair Associated With MSH3";"Defective Mismatch Repair Associated With MSH6"
Medex_00063063-RA	2	Reactome: R-HSA-9029569;Reactome: R-HSA-804914	"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Transport of fatty acids"
Medex_00000891-RA	3	Reactome: R-HSA-6782315;MetaCyc: PWY-6700;MetaCyc: PWY-8106	"tRNA modification in the nucleus and cytosol";"Queuosine biosynthesis I (de novo)";"Queuosine biosynthesis III (queuosine salvage)"
Medex_00002896-RA	3	KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway"
Medex_00014642-RA	3	MetaCyc: PWY-6348;KEGG: 00740+3.1.3.2;KEGG: 00730+3.1.3.2	"Phosphate acquisition";"Riboflavin metabolism";"Thiamine metabolism"
Medex_00013942-RA	8	Reactome: R-HSA-2559580;Reactome: R-HSA-212300;Reactome: R-HSA-5617472;Reactome: R-HSA-4551638;Reactome: R-HSA-9609690;Reactome: R-HSA-8953750;Reactome: R-HSA-3214841;Reactome: R-HSA-8943724	"Oxidative Stress Induced Senescence";"PRC2 methylates histones and DNA";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"SUMOylation of chromatin organization proteins";"HCMV Early Events";"Transcriptional Regulation by E2F6";"PKMTs methylate histone lysines";"Regulation of PTEN gene transcription"
Medex_00020308-RA	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
Medex_00014464-RA	2	MetaCyc: PWY-6854;Reactome: R-HSA-3299685	"Ethylene biosynthesis III (microbes)";"Detoxification of Reactive Oxygen Species"
Medex_00014183-RA	1	KEGG: 00970+6.1.1.19	"Aminoacyl-tRNA biosynthesis"
Medex_00027030-RA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
Medex_00059677-RA	1	Reactome: R-HSA-2132295	"MHC class II antigen presentation"
Medex_00074136-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Medex_00066471-RA	1	Reactome: R-HSA-420499	"Class C/3 (Metabotropic glutamate/pheromone receptors)"
Medex_00058786-RA	3	KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16	"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
Medex_00069380-RA	13	MetaCyc: PWY-6842;KEGG: 00053+1.8.5.1;KEGG: 00982+2.5.1.18;MetaCyc: PWY-7533;KEGG: 00983+2.5.1.18;MetaCyc: PWY-2261;KEGG: 00480+2.5.1.18+1.8.5.1;KEGG: 00980+2.5.1.18;Reactome: R-HSA-196836;MetaCyc: PWY-7112;MetaCyc: PWY-6370;MetaCyc: PWY-4061;Reactome: R-HSA-156590	"Glutathione-mediated detoxification II";"Ascorbate and aldarate metabolism";"Drug metabolism - cytochrome P450";"Gliotoxin biosynthesis";"Drug metabolism - other enzymes";"Ascorbate glutathione cycle";"Glutathione metabolism";"Metabolism of xenobiotics by cytochrome P450";"Vitamin C (ascorbate) metabolism";"4-hydroxy-2-nonenal detoxification";"Ascorbate recycling (cytosolic)";"Glutathione-mediated detoxification I";"Glutathione conjugation"
Medex_00050337-RA	4	Reactome: R-HSA-159236;Reactome: R-HSA-72163;Reactome: R-HSA-73856;Reactome: R-HSA-72187	"Transport of Mature mRNA derived from an Intron-Containing Transcript";"mRNA Splicing - Major Pathway";"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing"
Medex_00083475-RA	13	Reactome: R-HSA-192823;Reactome: R-HSA-975957;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-9633012;Reactome: R-HSA-156902;Reactome: R-HSA-1799339;Reactome: R-HSA-72764;Reactome: R-HSA-72689;Reactome: R-HSA-975956;Reactome: R-HSA-72706;Reactome: R-HSA-6791226;Reactome: R-HSA-2408557	"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Peptide chain elongation";"SRP-dependent cotranslational protein targeting to membrane";"Eukaryotic Translation Termination";"Formation of a pool of free 40S subunits";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Major pathway of rRNA processing in the nucleolus and cytosol";"Selenocysteine synthesis"
Medex_00091988-RA	26	Reactome: R-HSA-3371568;Reactome: R-HSA-918233;Reactome: R-HSA-5617472;Reactome: R-HSA-1368082;Reactome: R-HSA-9018519;Reactome: R-HSA-2894862;Reactome: R-HSA-3899300;Reactome: R-HSA-5621575;Reactome: R-HSA-933541;Reactome: R-HSA-9614657;Reactome: R-HSA-1234158;Reactome: R-HSA-8866907;Reactome: R-HSA-9013695;Reactome: R-HSA-2122947;Reactome: R-HSA-381340;Reactome: R-HSA-210744;Reactome: R-HSA-400253;Reactome: R-HSA-1989781;Reactome: R-HSA-1912408;Reactome: R-HSA-9013508;Reactome: R-HSA-3214847;Reactome: R-HSA-201722;Reactome: R-HSA-9617629;Reactome: R-HSA-2644606;Reactome: R-HSA-8941856;Reactome: R-HSA-3134973	"Attenuation phase";"TRAF3-dependent IRF activation pathway";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"RORA activates gene expression";"Estrogen-dependent gene expression";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"SUMOylation of transcription cofactors";"CD209 (DC-SIGN) signaling";"TRAF6 mediated IRF7 activation";"FOXO-mediated transcription of cell death genes";"Regulation of gene expression by Hypoxia-inducible Factor";"Activation of the TFAP2 (AP-2) family of transcription factors";"NOTCH4 Intracellular Domain Regulates Transcription";"NOTCH1 Intracellular Domain Regulates Transcription";"Transcriptional regulation of white adipocyte differentiation";"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"Circadian Clock";"PPARA activates gene expression";"Pre-NOTCH Transcription and Translation";"NOTCH3 Intracellular Domain Regulates Transcription";"HATs acetylate histones";"Formation of the beta-catenin:TCF transactivating complex";"Regulation of FOXO transcriptional activity by acetylation";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"RUNX3 regulates NOTCH signaling";"LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production"
Medex_00046536-RA	1	Reactome: R-HSA-379726	"Mitochondrial tRNA aminoacylation"
Medex_00041300-RA	6	KEGG: 00604+3.2.1.23;MetaCyc: PWY-6807;KEGG: 00511+3.2.1.23;KEGG: 00600+3.2.1.23;KEGG: 00531+3.2.1.23;KEGG: 00052+3.2.1.23	"Glycosphingolipid biosynthesis - ganglio series";"Xyloglucan degradation II (exoglucanase)";"Other glycan degradation";"Sphingolipid metabolism";"Glycosaminoglycan degradation";"Galactose metabolism"
Medex_00006289-RA	15	Reactome: R-HSA-9022692;Reactome: R-HSA-4086398;Reactome: R-HSA-8948700;Reactome: R-HSA-9029569;Reactome: R-HSA-2559580;Reactome: R-HSA-8943723;Reactome: R-HSA-8853884;Reactome: R-HSA-8934593;Reactome: R-HSA-5687128;Reactome: R-HSA-8936459;Reactome: R-HSA-8986944;Reactome: R-HSA-2559585;Reactome: R-HSA-5628897;Reactome: R-HSA-9018519;Reactome: R-HSA-1912408	"Regulation of MECP2 expression and activity";"Ca2+ pathway";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Oxidative Stress Induced Senescence";"Regulation of PTEN mRNA translation";"Transcriptional Regulation by VENTX";"Regulation of RUNX1 Expression and Activity";"MAPK6/MAPK4 signaling";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Transcriptional Regulation by MECP2";"Oncogene Induced Senescence";"TP53 Regulates Metabolic Genes";"Estrogen-dependent gene expression";"Pre-NOTCH Transcription and Translation"
Medex_00024706-RA	13	Reactome: R-HSA-1799339;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-156902;Reactome: R-HSA-9633012;Reactome: R-HSA-975957;Reactome: R-HSA-192823;Reactome: R-HSA-2408557;Reactome: R-HSA-6791226;Reactome: R-HSA-975956;Reactome: R-HSA-72706;Reactome: R-HSA-72689;Reactome: R-HSA-72764	"SRP-dependent cotranslational protein targeting to membrane";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Peptide chain elongation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Viral mRNA Translation";"Selenocysteine synthesis";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Formation of a pool of free 40S subunits";"Eukaryotic Translation Termination"
Medex_00082818-RA	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
Medex_00074738-RA	3	Reactome: R-HSA-2142691;Reactome: R-HSA-5423646;MetaCyc: PWY-7533	"Synthesis of Leukotrienes (LT) and Eoxins (EX)";"Aflatoxin activation and detoxification";"Gliotoxin biosynthesis"
Medex_00084570-RA	7	Reactome: R-HSA-5658034;Reactome: R-HSA-373080;Reactome: R-HSA-5362798;Reactome: R-HSA-5635838;Reactome: R-HSA-5632681;Reactome: R-HSA-5358346;Reactome: R-HSA-5632684	"HHAT G278V abrogates palmitoylation of Hh-Np";"Class B/2 (Secretin family receptors)";"Release of Hh-Np from the secreting cell";"Activation of SMO";"Ligand-receptor interactions";"Hedgehog ligand biogenesis";"Hedgehog 'on' state"
Medex_00017070-RA	9	KEGG: 00531+3.2.1.52;KEGG: 00520+3.2.1.52;KEGG: 00603+3.2.1.52;MetaCyc: PWY-6902;MetaCyc: PWY-7883;KEGG: 00604+3.2.1.52;MetaCyc: PWY-7822;KEGG: 00513+3.2.1.52;KEGG: 00511+3.2.1.52	"Glycosaminoglycan degradation";"Amino sugar and nucleotide sugar metabolism";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Chitin degradation II (Vibrio)";"Anhydromuropeptides recycling II";"Glycosphingolipid biosynthesis - ganglio series";"Chitin degradation III (Serratia)";"Various types of N-glycan biosynthesis";"Other glycan degradation"
Medex_00062809-RA	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840	"Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation"
Medex_00061377-RA	7	KEGG: 00230+2.4.2.14;MetaCyc: PWY-6122;MetaCyc: PWY-7282;MetaCyc: PWY-6277;MetaCyc: PWY-6121;KEGG: 00250+2.4.2.14;Reactome: R-HSA-73817	"Purine metabolism";"5-aminoimidazole ribonucleotide biosynthesis II";"4-amino-2-methyl-5-phosphomethylpyrimidine biosynthesis";"Superpathway of 5-aminoimidazole ribonucleotide biosynthesis";"5-aminoimidazole ribonucleotide biosynthesis I";"Alanine, aspartate and glutamate metabolism";"Purine ribonucleoside monophosphate biosynthesis"
Medex_00053807-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Medex_00067030-RA	9	Reactome: R-HSA-5696400;Reactome: R-HSA-110314;Reactome: R-HSA-6782135;Reactome: R-HSA-6782210;Reactome: R-HSA-5696394;Reactome: R-HSA-6781827;Reactome: R-HSA-5696395;Reactome: R-HSA-6781823;Reactome: R-HSA-8951664	"Dual Incision in GG-NER";"Recognition of DNA damage by PCNA-containing replication complex";"Dual incision in TC-NER";"Gap-filling DNA repair synthesis and ligation in TC-NER";"DNA Damage Recognition in GG-NER";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Formation of Incision Complex in GG-NER";"Formation of TC-NER Pre-Incision Complex";"Neddylation"
Medex_00029559-RA	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
Medex_00022060-RA	3	Reactome: R-HSA-73856;Reactome: R-HSA-111367;Reactome: R-HSA-77588	"RNA Polymerase II Transcription Termination";"SLBP independent Processing of Histone Pre-mRNAs";"SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs"
Medex_00030534-RA	2	Reactome: R-HSA-5357905;Reactome: R-HSA-5357956	"Regulation of TNFR1 signaling";"TNFR1-induced NFkappaB signaling pathway"
Medex_00066255-RA	13	Reactome: R-HSA-8943724;Reactome: R-HSA-6804757;Reactome: R-HSA-5218920;Reactome: R-HSA-389357;Reactome: R-HSA-5628897;Reactome: R-HSA-5674400;Reactome: R-HSA-1257604;Reactome: R-HSA-9639288;Reactome: R-HSA-165159;Reactome: R-HSA-1632852;Reactome: R-HSA-166208;Reactome: R-HSA-380972;Reactome: R-HSA-3371571	"Regulation of PTEN gene transcription";"Regulation of TP53 Degradation";"VEGFR2 mediated vascular permeability";"CD28 dependent PI3K/Akt signaling";"TP53 Regulates Metabolic Genes";"Constitutive Signaling by AKT1 E17K in Cancer";"PIP3 activates AKT signaling";"Amino acids regulate mTORC1";"mTOR signalling";"Macroautophagy";"mTORC1-mediated signalling";"Energy dependent regulation of mTOR by LKB1-AMPK";"HSF1-dependent transactivation"
Medex_00051566-RA	1	Reactome: R-HSA-6811440	"Retrograde transport at the Trans-Golgi-Network"
Medex_00082290-RA	4	Reactome: R-HSA-8856825;Reactome: R-HSA-6781823;Reactome: R-HSA-5696394;Reactome: R-HSA-8951664	"Cargo recognition for clathrin-mediated endocytosis";"Formation of TC-NER Pre-Incision Complex";"DNA Damage Recognition in GG-NER";"Neddylation"
Medex_00021582-RA	5	MetaCyc: PWY-6277;MetaCyc: PWY-6122;Reactome: R-HSA-73817;MetaCyc: PWY-6121;KEGG: 00230+6.3.4.13	"Superpathway of 5-aminoimidazole ribonucleotide biosynthesis";"5-aminoimidazole ribonucleotide biosynthesis II";"Purine ribonucleoside monophosphate biosynthesis";"5-aminoimidazole ribonucleotide biosynthesis I";"Purine metabolism"
Medex_00025204-RA	1	Reactome: R-HSA-1474228	"Degradation of the extracellular matrix"
Medex_00018080-RA	1	Reactome: R-HSA-5693571	"Nonhomologous End-Joining (NHEJ)"
Medex_00090128-RA	2	Reactome: R-HSA-8876725;Reactome: R-HSA-611105	"Protein methylation";"Respiratory electron transport"
Medex_00021952-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00050270-RA	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
Medex_00021584-RA	5	MetaCyc: PWY-6277;MetaCyc: PWY-6122;Reactome: R-HSA-73817;KEGG: 00230+6.3.4.13;MetaCyc: PWY-6121	"Superpathway of 5-aminoimidazole ribonucleotide biosynthesis";"5-aminoimidazole ribonucleotide biosynthesis II";"Purine ribonucleoside monophosphate biosynthesis";"Purine metabolism";"5-aminoimidazole ribonucleotide biosynthesis I"
Medex_00026902-RA	2	Reactome: R-HSA-381038;Reactome: R-HSA-1799339	"XBP1(S) activates chaperone genes";"SRP-dependent cotranslational protein targeting to membrane"
Medex_00058085-RA	33	Reactome: R-HSA-167200;Reactome: R-HSA-167246;Reactome: R-HSA-167160;Reactome: R-HSA-75955;Reactome: R-HSA-6782135;Reactome: R-HSA-69202;Reactome: R-HSA-167172;Reactome: R-HSA-6781823;Reactome: R-HSA-112382;Reactome: R-HSA-73779;Reactome: R-HSA-113418;Reactome: R-HSA-167161;Reactome: R-HSA-69231;Reactome: R-HSA-75953;Reactome: R-HSA-69273;Reactome: R-HSA-69656;Reactome: R-HSA-167162;Reactome: R-HSA-76042;Reactome: R-HSA-73863;Reactome: R-HSA-167152;Reactome: R-HSA-674695;Reactome: R-HSA-8939236;Reactome: R-HSA-73776;Reactome: R-HSA-6782210;Reactome: R-HSA-73772;Reactome: R-HSA-427413;Reactome: R-HSA-77075;Reactome: R-HSA-72086;Reactome: R-HSA-6796648;Reactome: R-HSA-73762;Reactome: R-HSA-6781827;Reactome: R-HSA-167158;Reactome: R-HSA-5696395	"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Tat-mediated elongation of the HIV-1 transcript";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"RNA Polymerase II Transcription Elongation";"Dual incision in TC-NER";"Cyclin E associated events during G1/S transition";"Transcription of the HIV genome";"Formation of TC-NER Pre-Incision Complex";"Formation of RNA Pol II elongation complex";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Formation of the Early Elongation Complex";"HIV Transcription Initiation";"Cyclin D associated events in G1";"RNA Polymerase II Transcription Initiation";"Cyclin A/B1/B2 associated events during G2/M transition";"Cyclin A:Cdk2-associated events at S phase entry";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase I Transcription Termination";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Polymerase II Pre-transcription Events";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"RNA Polymerase II Promoter Escape";"Gap-filling DNA repair synthesis and ligation in TC-NER";"RNA Polymerase I Promoter Escape";"NoRC negatively regulates rRNA expression";"RNA Pol II CTD phosphorylation and interaction with CE";"mRNA Capping";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase I Transcription Initiation";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Formation of the HIV-1 Early Elongation Complex";"Formation of Incision Complex in GG-NER"
Medex_00004112-RA	3	Reactome: R-HSA-4420097;Reactome: R-HSA-2029482;Reactome: R-HSA-5663213	"VEGFA-VEGFR2 Pathway";"Regulation of actin dynamics for phagocytic cup formation";"RHO GTPases Activate WASPs and WAVEs"
Medex_00041023-RA	2	Reactome: R-HSA-2672351;Reactome: R-HSA-5578775	"Stimuli-sensing channels";"Ion homeostasis"
Medex_00034151-RA	1	Reactome: R-HSA-1971475	"A tetrasaccharide linker sequence is required for GAG synthesis"
Medex_00064425-RA	6	Reactome: R-HSA-114508;MetaCyc: PWY-7039;KEGG: 00564+2.7.1.107;KEGG: 04070+2.7.1.107;MetaCyc: PWY-7817;KEGG: 00561+2.7.1.107	"Effects of PIP2 hydrolysis";"Phosphatidate metabolism, as a signaling molecule";"Glycerophospholipid metabolism";"Phosphatidylinositol signaling system";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Glycerolipid metabolism"
Medex_00044630-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Medex_00031080-RA	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
Medex_00082551-RA	2	Reactome: R-HSA-390918;Reactome: R-HSA-9033241	"Peroxisomal lipid metabolism";"Peroxisomal protein import"
Medex_00013450-RA	2	Reactome: R-HSA-72163;Reactome: R-HSA-6807505	"mRNA Splicing - Major Pathway";"RNA polymerase II transcribes snRNA genes"
Medex_00038525-RA	4	MetaCyc: PWY-7375;Reactome: R-HSA-72086;Reactome: R-HSA-167160;Reactome: R-HSA-77075	"Mrna capping I";"mRNA Capping";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"RNA Pol II CTD phosphorylation and interaction with CE"
Medex_00026308-RA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
Medex_00003588-RA	3	Reactome: R-HSA-430039;Reactome: R-HSA-450385;Reactome: R-HSA-450513	"mRNA decay by 5' to 3' exoribonuclease";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA"
Medex_00056845-RA	3	Reactome: R-HSA-6811438;Reactome: R-HSA-6811440;Reactome: R-HSA-6807878	"Intra-Golgi traffic";"Retrograde transport at the Trans-Golgi-Network";"COPI-mediated anterograde transport"
Medex_00093560-RA	16	Reactome: R-HSA-975957;Reactome: R-HSA-9633012;Reactome: R-HSA-1799339;Reactome: R-HSA-72764;Reactome: R-HSA-72706;Reactome: R-HSA-975956;Reactome: R-HSA-6791226;Reactome: R-HSA-72702;Reactome: R-HSA-192823;Reactome: R-HSA-72695;Reactome: R-HSA-156902;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-72649;Reactome: R-HSA-72689;Reactome: R-HSA-2408557	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"SRP-dependent cotranslational protein targeting to membrane";"Eukaryotic Translation Termination";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"Ribosomal scanning and start codon recognition";"Viral mRNA Translation";"Formation of the ternary complex, and subsequently, the 43S complex";"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Translation initiation complex formation";"Formation of a pool of free 40S subunits";"Selenocysteine synthesis"
Medex_00003842-RA	2	Reactome: R-HSA-3299685;KEGG: 00480+1.11.1.15	"Detoxification of Reactive Oxygen Species";"Glutathione metabolism"
Medex_00004861-RA	5	Reactome: R-HSA-159231;Reactome: R-HSA-77595;Reactome: R-HSA-72163;Reactome: R-HSA-72187;Reactome: R-HSA-73856	"Transport of Mature mRNA Derived from an Intronless Transcript";"Processing of Intronless Pre-mRNAs";"mRNA Splicing - Major Pathway";"mRNA 3'-end processing";"RNA Polymerase II Transcription Termination"
Medex_00060399-RA	13	Reactome: R-HSA-156902;Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-1799339;Reactome: R-HSA-192823;Reactome: R-HSA-975957;Reactome: R-HSA-6791226;Reactome: R-HSA-2408557;Reactome: R-HSA-72689;Reactome: R-HSA-72764;Reactome: R-HSA-72706;Reactome: R-HSA-975956	"Peptide chain elongation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"SRP-dependent cotranslational protein targeting to membrane";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"Selenocysteine synthesis";"Formation of a pool of free 40S subunits";"Eukaryotic Translation Termination";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"
Medex_00019625-RA	4	KEGG: 00230+2.7.4.3;KEGG: 00730+2.7.4.3;Reactome: R-HSA-499943;MetaCyc: PWY-7219	"Purine metabolism";"Thiamine metabolism";"Interconversion of nucleotide di- and triphosphates";"Adenosine ribonucleotides de novo biosynthesis"
Medex_00049328-RA	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
Medex_00007914-RA	1	Reactome: R-HSA-9022692	"Regulation of MECP2 expression and activity"
Medex_00056196-RA	2	Reactome: R-HSA-5218920;Reactome: R-HSA-418990	"VEGFR2 mediated vascular permeability";"Adherens junctions interactions"
Medex_00027191-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Medex_00041299-RA	6	KEGG: 00531+3.2.1.23;KEGG: 00052+3.2.1.23;KEGG: 00604+3.2.1.23;MetaCyc: PWY-6807;KEGG: 00511+3.2.1.23;KEGG: 00600+3.2.1.23	"Glycosaminoglycan degradation";"Galactose metabolism";"Glycosphingolipid biosynthesis - ganglio series";"Xyloglucan degradation II (exoglucanase)";"Other glycan degradation";"Sphingolipid metabolism"
Medex_00068363-RA	4	MetaCyc: PWY-7511;Reactome: R-HSA-975144;Reactome: R-HSA-937039;Reactome: R-HSA-9020702	"Protein ubiquitination";"IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation";"IRAK1 recruits IKK complex";"Interleukin-1 signaling"
Medex_00004864-RA	5	Reactome: R-HSA-72163;Reactome: R-HSA-77595;Reactome: R-HSA-73856;Reactome: R-HSA-72187;Reactome: R-HSA-159231	"mRNA Splicing - Major Pathway";"Processing of Intronless Pre-mRNAs";"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing";"Transport of Mature mRNA Derived from an Intronless Transcript"
Medex_00026841-RA	1	Reactome: R-HSA-6790901	"rRNA modification in the nucleus and cytosol"
Medex_00052653-RA	32	Reactome: R-HSA-75953;Reactome: R-HSA-167161;Reactome: R-HSA-6807505;Reactome: R-HSA-113418;Reactome: R-HSA-73779;Reactome: R-HSA-112382;Reactome: R-HSA-8851708;Reactome: R-HSA-167290;Reactome: R-HSA-167172;Reactome: R-HSA-72163;Reactome: R-HSA-167242;Reactome: R-HSA-75955;Reactome: R-HSA-9018519;Reactome: R-HSA-167246;Reactome: R-HSA-167160;Reactome: R-HSA-167200;Reactome: R-HSA-167158;Reactome: R-HSA-6803529;Reactome: R-HSA-167238;Reactome: R-HSA-6796648;Reactome: R-HSA-72086;Reactome: R-HSA-168325;Reactome: R-HSA-77075;Reactome: R-HSA-72203;Reactome: R-HSA-73776;Reactome: R-HSA-674695;Reactome: R-HSA-167152;Reactome: R-HSA-167243;Reactome: R-HSA-167287;Reactome: R-HSA-76042;Reactome: R-HSA-167162;Reactome: R-HSA-72165	"RNA Polymerase II Transcription Initiation";"HIV Transcription Initiation";"RNA polymerase II transcribes snRNA genes";"Formation of the Early Elongation Complex";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Formation of RNA Pol II elongation complex";"Signaling by FGFR2 IIIa TM";"Pausing and recovery of HIV elongation";"Transcription of the HIV genome";"mRNA Splicing - Major Pathway";"Abortive elongation of HIV-1 transcript in the absence of Tat";"RNA Polymerase II Transcription Elongation";"Estrogen-dependent gene expression";"Tat-mediated elongation of the HIV-1 transcript";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Formation of the HIV-1 Early Elongation Complex";"FGFR2 alternative splicing";"Pausing and recovery of Tat-mediated HIV elongation";"TP53 Regulates Transcription of DNA Repair Genes";"mRNA Capping";"Viral Messenger RNA Synthesis";"RNA Pol II CTD phosphorylation and interaction with CE";"Processing of Capped Intron-Containing Pre-mRNA";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Pre-transcription Events";"Formation of HIV elongation complex in the absence of HIV Tat";"Tat-mediated HIV elongation arrest and recovery";"HIV elongation arrest and recovery";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II HIV Promoter Escape";"mRNA Splicing - Minor Pathway"
Medex_00022373-RA	7	MetaCyc: PWY-7841;Reactome: R-HSA-1660662;KEGG: 00600+2.4.1.80;MetaCyc: PWY-7836;MetaCyc: PWY-7838;MetaCyc: PWY-7839;MetaCyc: PWY-5129	"Neolacto-series glycosphingolipids biosynthesis";"Glycosphingolipid metabolism";"Sphingolipid metabolism";"Ganglio-series glycosphingolipids biosynthesis";"Globo-series glycosphingolipids biosynthesis";"Lacto-series glycosphingolipids biosynthesis";"Sphingolipid biosynthesis (plants)"
Medex_00034107-RA	2	Reactome: R-HSA-6798695;Reactome: R-HSA-1799339	"Neutrophil degranulation";"SRP-dependent cotranslational protein targeting to membrane"
Medex_00023217-RA	3	Reactome: R-HSA-1989781;Reactome: R-HSA-381340;Reactome: R-HSA-212436	"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation";"Generic Transcription Pathway"
Medex_00054080-RA	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
Medex_00016734-RA	2	Reactome: R-HSA-6803205;Reactome: R-HSA-8873719	"TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain";"RAB geranylgeranylation"
Medex_00048587-RA	1	Reactome: R-HSA-202733	"Cell surface interactions at the vascular wall"
Medex_00010672-RA	4	Reactome: R-HSA-6782315;Reactome: R-HSA-72764;Reactome: R-HSA-156581;Reactome: R-HSA-6790901	"tRNA modification in the nucleus and cytosol";"Eukaryotic Translation Termination";"Methylation";"rRNA modification in the nucleus and cytosol"
Medex_00076479-RA	3	Reactome: R-HSA-6798695;MetaCyc: PWY-6807;KEGG: 00511+3.2.1.51	"Neutrophil degranulation";"Xyloglucan degradation II (exoglucanase)";"Other glycan degradation"
Medex_00056785-RA	1	KEGG: 00970+6.3.5.7	"Aminoacyl-tRNA biosynthesis"
Medex_00011275-RA	2	Reactome: R-HSA-6784531;Reactome: R-HSA-6791226	"tRNA processing in the nucleus";"Major pathway of rRNA processing in the nucleolus and cytosol"
Medex_00077462-RA	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
Medex_00035607-RA	2	Reactome: R-HSA-379726;KEGG: 00970+6.1.1.1	"Mitochondrial tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis"
Medex_00012263-RA	2	Reactome: R-HSA-380320;Reactome: R-HSA-380270	"Recruitment of NuMA to mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes"
Medex_00011931-RA	1	Reactome: R-HSA-5250924	"B-WICH complex positively regulates rRNA expression"
Medex_00034237-RA	1	Reactome: R-HSA-5578775	"Ion homeostasis"
Medex_00075581-RA	29	Reactome: R-HSA-6782210;Reactome: R-HSA-6781823;Reactome: R-HSA-167172;Reactome: R-HSA-73772;Reactome: R-HSA-73863;Reactome: R-HSA-674695;Reactome: R-HSA-167152;Reactome: R-HSA-73776;Reactome: R-HSA-75955;Reactome: R-HSA-167162;Reactome: R-HSA-6782135;Reactome: R-HSA-76042;Reactome: R-HSA-167200;Reactome: R-HSA-167160;Reactome: R-HSA-167246;Reactome: R-HSA-75953;Reactome: R-HSA-6781827;Reactome: R-HSA-167161;Reactome: R-HSA-5696395;Reactome: R-HSA-167158;Reactome: R-HSA-113418;Reactome: R-HSA-73762;Reactome: R-HSA-112382;Reactome: R-HSA-5696400;Reactome: R-HSA-72086;Reactome: R-HSA-73779;Reactome: R-HSA-6796648;Reactome: R-HSA-427413;Reactome: R-HSA-77075	"Gap-filling DNA repair synthesis and ligation in TC-NER";"Formation of TC-NER Pre-Incision Complex";"Transcription of the HIV genome";"RNA Polymerase I Promoter Escape";"RNA Polymerase I Transcription Termination";"RNA Polymerase II Pre-transcription Events";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Transcription Elongation";"RNA Polymerase II HIV Promoter Escape";"Dual incision in TC-NER";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Tat-mediated elongation of the HIV-1 transcript";"RNA Polymerase II Transcription Initiation";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"HIV Transcription Initiation";"Formation of Incision Complex in GG-NER";"Formation of the HIV-1 Early Elongation Complex";"Formation of the Early Elongation Complex";"RNA Polymerase I Transcription Initiation";"Formation of RNA Pol II elongation complex";"Dual Incision in GG-NER";"mRNA Capping";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"TP53 Regulates Transcription of DNA Repair Genes";"NoRC negatively regulates rRNA expression";"RNA Pol II CTD phosphorylation and interaction with CE"
Medex_00024489-RA	2	Reactome: R-HSA-1660662;Reactome: R-HSA-390471	"Glycosphingolipid metabolism";"Association of TriC/CCT with target proteins during biosynthesis"
Medex_00029103-RA	5	Reactome: R-HSA-2214320;Reactome: R-HSA-1650814;Reactome: R-HSA-1474228;Reactome: R-HSA-2243919;Reactome: R-HSA-8963896	"Anchoring fibril formation";"Collagen biosynthesis and modifying enzymes";"Degradation of the extracellular matrix";"Crosslinking of collagen fibrils";"HDL assembly"
Medex_00067242-RA	11	Reactome: R-HSA-5656169;Reactome: R-HSA-5651801;Reactome: R-HSA-68952;Reactome: R-HSA-5696400;Reactome: R-HSA-68962;Reactome: R-HSA-6782135;Reactome: R-HSA-110314;Reactome: R-HSA-5685942;Reactome: R-HSA-5696397;Reactome: R-HSA-174430;Reactome: R-HSA-6782210	"Termination of translesion DNA synthesis";"PCNA-Dependent Long Patch Base Excision Repair";"DNA replication initiation";"Dual Incision in GG-NER";"Activation of the pre-replicative complex";"Dual incision in TC-NER";"Recognition of DNA damage by PCNA-containing replication complex";"HDR through Homologous Recombination (HRR)";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Telomere C-strand synthesis initiation";"Gap-filling DNA repair synthesis and ligation in TC-NER"
Medex_00001776-RA	2	Reactome: R-HSA-9033241;Reactome: R-HSA-389661	"Peroxisomal protein import";"Glyoxylate metabolism and glycine degradation"
Medex_00051319-RA	3	Reactome: R-HSA-212436;Reactome: R-HSA-1989781;Reactome: R-HSA-381340	"Generic Transcription Pathway";"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation"
Medex_00083536-RA	2	Reactome: R-HSA-611105;Reactome: R-HSA-71403	"Respiratory electron transport";"Citric acid cycle (TCA cycle)"
Medex_00034428-RA	5	Reactome: R-HSA-9639288;Reactome: R-HSA-1222556;Reactome: R-HSA-983712;Reactome: R-HSA-77387;Reactome: R-HSA-917977	"Amino acids regulate mTORC1";"ROS and RNS production in phagocytes";"Ion channel transport";"Insulin receptor recycling";"Transferrin endocytosis and recycling"
Medex_00001746-RA	1	Reactome: R-HSA-6803157	"Antimicrobial peptides"
Medex_00063438-RA	6	Reactome: R-HSA-72689;Reactome: R-HSA-72706;Reactome: R-HSA-156827;Reactome: R-HSA-72695;Reactome: R-HSA-72702;Reactome: R-HSA-72649	"Formation of a pool of free 40S subunits";"GTP hydrolysis and joining of the 60S ribosomal subunit";"L13a-mediated translational silencing of Ceruloplasmin expression";"Formation of the ternary complex, and subsequently, the 43S complex";"Ribosomal scanning and start codon recognition";"Translation initiation complex formation"
Medex_00087005-RA	4	Reactome: R-HSA-2408557;MetaCyc: PWY-6281;KEGG: 00970+2.9.1.2;KEGG: 00450+2.9.1.2	"Selenocysteine synthesis";"L-selenocysteine biosynthesis II (archaea and eukaryotes)";"Aminoacyl-tRNA biosynthesis";"Selenocompound metabolism"
Medex_00011910-RA	1	Reactome: R-HSA-5620922	"BBSome-mediated cargo-targeting to cilium"
Medex_00052534-RA	1	Reactome: R-HSA-5620912	"Anchoring of the basal body to the plasma membrane"
Medex_00065179-RA	1	Reactome: R-HSA-6787450	"tRNA modification in the mitochondrion"
Medex_00069642-RA	1	KEGG: 00480+3.4.11.2	"Glutathione metabolism"
Medex_00025916-RA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
Medex_00081022-RA	6	Reactome: R-HSA-6791226;Reactome: R-HSA-429958;Reactome: R-HSA-380994;Reactome: R-HSA-450513;Reactome: R-HSA-450604;Reactome: R-HSA-450385	"Major pathway of rRNA processing in the nucleolus and cytosol";"mRNA decay by 3' to 5' exoribonuclease";"ATF4 activates genes in response to endoplasmic reticulum stress";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"KSRP (KHSRP) binds and destabilizes mRNA";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA"
Medex_00067620-RA	5	Reactome: R-HSA-204005;Reactome: R-HSA-6811438;Reactome: R-HSA-5694530;Reactome: R-HSA-9609523;Reactome: R-HSA-6807878	"COPII-mediated vesicle transport";"Intra-Golgi traffic";"Cargo concentration in the ER";"Insertion of tail-anchored proteins into the endoplasmic reticulum membrane";"COPI-mediated anterograde transport"
Medex_00054755-RA	1	Reactome: R-HSA-70221	"Glycogen breakdown (glycogenolysis)"
Medex_00006218-RA	1	Reactome: R-HSA-169911	"Regulation of Apoptosis"
Medex_00002494-RA	6	Reactome: R-HSA-446210;MetaCyc: PWY-6906;KEGG: 00520+5.4.2.10;KEGG: 00520+5.4.2.3;MetaCyc: PWY-6749;MetaCyc: PWY-5514	"Synthesis of UDP-N-acetyl-glucosamine";"Chitin derivatives degradation";"Amino sugar and nucleotide sugar metabolism";"Amino sugar and nucleotide sugar metabolism";"CMP-legionaminate biosynthesis I";"UDP-N-acetyl-D-galactosamine biosynthesis II"
Medex_00045008-RA	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
Medex_00072218-RA	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
Medex_00091069-RA	16	Reactome: R-HSA-2408557;Reactome: R-HSA-72689;Reactome: R-HSA-72695;Reactome: R-HSA-156902;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-72649;Reactome: R-HSA-192823;Reactome: R-HSA-6791226;Reactome: R-HSA-72702;Reactome: R-HSA-72764;Reactome: R-HSA-72706;Reactome: R-HSA-975956;Reactome: R-HSA-9633012;Reactome: R-HSA-1799339;Reactome: R-HSA-975957	"Selenocysteine synthesis";"Formation of a pool of free 40S subunits";"Formation of the ternary complex, and subsequently, the 43S complex";"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Translation initiation complex formation";"Viral mRNA Translation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Ribosomal scanning and start codon recognition";"Eukaryotic Translation Termination";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
Medex_00060263-RA	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
Medex_00009500-RA	5	Reactome: R-HSA-204005;Reactome: R-HSA-2132295;Reactome: R-HSA-5694530;Reactome: R-HSA-1655829;Reactome: R-HSA-983170	"COPII-mediated vesicle transport";"MHC class II antigen presentation";"Cargo concentration in the ER";"Regulation of cholesterol biosynthesis by SREBP (SREBF)";"Antigen Presentation: Folding, assembly and peptide loading of class I MHC"
Medex_00008044-RA	2	Reactome: R-HSA-3214858;Reactome: R-HSA-8939243	"RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"
Medex_00075834-RA	7	Reactome: R-HSA-168333;Reactome: R-HSA-203927;Reactome: R-HSA-165054;Reactome: R-HSA-6784531;Reactome: R-HSA-5578749;Reactome: R-HSA-1655829;Reactome: R-HSA-180746	"NEP/NS2 Interacts with the Cellular Export Machinery";"MicroRNA (miRNA) biogenesis";"Rev-mediated nuclear export of HIV RNA";"tRNA processing in the nucleus";"Transcriptional regulation by small RNAs";"Regulation of cholesterol biosynthesis by SREBP (SREBF)";"Nuclear import of Rev protein"
Medex_00081069-RA	3	Reactome: R-HSA-2408508;Reactome: R-HSA-1614603;Reactome: R-HSA-1614558	"Metabolism of ingested SeMet, Sec, MeSec into H2Se";"Cysteine formation from homocysteine";"Degradation of cysteine and homocysteine"
Medex_00015439-RA	3	KEGG: 04070+2.7.4.24+2.7.4.21;Reactome: R-HSA-1855167;MetaCyc: PWY-6369	"Phosphatidylinositol signaling system";"Synthesis of pyrophosphates in the cytosol";"Inositol diphosphates biosynthesis"
Medex_00004645-RA	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
Medex_00047531-RA	3	Reactome: R-HSA-1660516;Reactome: R-HSA-1660517;Reactome: R-HSA-1660514	"Synthesis of PIPs at the early endosome membrane";"Synthesis of PIPs at the late endosome membrane";"Synthesis of PIPs at the Golgi membrane"
Medex_00036861-RA	33	Reactome: R-HSA-5578749;Reactome: R-HSA-168276;Reactome: R-HSA-2500257;Reactome: R-HSA-4615885;Reactome: R-HSA-3371453;Reactome: R-HSA-180746;Reactome: R-HSA-165054;Reactome: R-HSA-3108214;Reactome: R-HSA-6784531;Reactome: R-HSA-159236;Reactome: R-HSA-9610379;Reactome: R-HSA-5619107;Reactome: R-HSA-9609690;Reactome: R-HSA-4085377;Reactome: R-HSA-4570464;Reactome: R-HSA-180910;Reactome: R-HSA-3301854;Reactome: R-HSA-159230;Reactome: R-HSA-5663220;Reactome: R-HSA-9648025;Reactome: R-HSA-159231;Reactome: R-HSA-68877;Reactome: R-HSA-159227;Reactome: R-HSA-1169408;Reactome: R-HSA-2467813;Reactome: R-HSA-168333;Reactome: R-HSA-141444;Reactome: R-HSA-168325;Reactome: R-HSA-191859;Reactome: R-HSA-4551638;Reactome: R-HSA-170822;Reactome: R-HSA-168271;Reactome: R-HSA-3232142	"Transcriptional regulation by small RNAs";"NS1 Mediated Effects on Host Pathways";"Resolution of Sister Chromatid Cohesion";"SUMOylation of DNA replication proteins";"Regulation of HSF1-mediated heat shock response";"Nuclear import of Rev protein";"Rev-mediated nuclear export of HIV RNA";"SUMOylation of DNA damage response and repair proteins";"tRNA processing in the nucleus";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"HCMV Late Events";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"HCMV Early Events";"SUMOylation of SUMOylation proteins";"SUMOylation of RNA binding proteins";"Vpr-mediated nuclear import of PICs";"Nuclear Pore Complex (NPC) Disassembly";"Transport of the SLBP Dependant Mature mRNA";"RHO GTPases Activate Formins";"EML4 and NUDC in mitotic spindle formation";"Transport of Mature mRNA Derived from an Intronless Transcript";"Mitotic Prometaphase";"Transport of the SLBP independent Mature mRNA";"ISG15 antiviral mechanism";"Separation of Sister Chromatids";"NEP/NS2 Interacts with the Cellular Export Machinery";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Viral Messenger RNA Synthesis";"snRNP Assembly";"SUMOylation of chromatin organization proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Transport of Ribonucleoproteins into the Host Nucleus";"SUMOylation of ubiquitinylation proteins"
Medex_00067997-RA	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276	"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination"
Medex_00063093-RA	1	Reactome: R-HSA-1614635	"Sulfur amino acid metabolism"
Medex_00004651-RA	5	Reactome: R-HSA-1222556;Reactome: R-HSA-9639288;Reactome: R-HSA-77387;Reactome: R-HSA-983712;Reactome: R-HSA-917977	"ROS and RNS production in phagocytes";"Amino acids regulate mTORC1";"Insulin receptor recycling";"Ion channel transport";"Transferrin endocytosis and recycling"
Medex_00014620-RA	2	Reactome: R-HSA-8949664;Reactome: R-HSA-8949215	"Processing of SMDT1";"Mitochondrial calcium ion transport"
Medex_00068446-RA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
Medex_00031892-RA	56	Reactome: R-HSA-174178;Reactome: R-HSA-5607761;Reactome: R-HSA-8852276;Reactome: R-HSA-5610780;Reactome: R-HSA-1236978;Reactome: R-HSA-349425;Reactome: R-HSA-180534;Reactome: R-HSA-5632684;Reactome: R-HSA-5668541;Reactome: R-HSA-5689603;Reactome: R-HSA-5687128;Reactome: R-HSA-4608870;Reactome: R-HSA-5610785;Reactome: R-HSA-5689880;Reactome: R-HSA-195253;Reactome: R-HSA-8939902;Reactome: R-HSA-75815;Reactome: R-HSA-9010553;Reactome: R-HSA-68949;Reactome: R-HSA-8939236;Reactome: R-HSA-382556;Reactome: R-HSA-211733;Reactome: R-HSA-180585;Reactome: R-HSA-450408;Reactome: R-HSA-4641258;Reactome: R-HSA-2467813;Reactome: R-HSA-9020702;Reactome: R-HSA-983168;Reactome: R-HSA-202424;Reactome: R-HSA-5658442;Reactome: R-HSA-5358346;Reactome: R-HSA-8941858;Reactome: R-HSA-8951664;Reactome: R-HSA-2871837;Reactome: R-HSA-5607764;Reactome: R-HSA-174184;Reactome: R-HSA-1169091;Reactome: R-HSA-174154;Reactome: R-HSA-8948751;Reactome: R-HSA-9604323;Reactome: R-HSA-68827;Reactome: R-HSA-69601;Reactome: R-HSA-69017;Reactome: R-HSA-1234176;Reactome: R-HSA-5362768;Reactome: R-HSA-5676590;Reactome: R-HSA-174113;Reactome: R-HSA-4641257;Reactome: R-HSA-69481;Reactome: R-HSA-5678895;Reactome: R-HSA-350562;Reactome: R-HSA-1236974;Reactome: R-HSA-8854050;Reactome: R-HSA-5610783;Reactome: R-HSA-187577;Reactome: R-HSA-174084	"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Dectin-1 mediated noncanonical NF-kB signaling";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Degradation of GLI1 by the proteasome";"Cross-presentation of soluble exogenous antigens (endosomes)";"Autodegradation of the E3 ubiquitin ligase COP1";"Vpu mediated degradation of CD4";"Hedgehog 'on' state";"TNFR2 non-canonical NF-kB pathway";"UCH proteinases";"MAPK6/MAPK4 signaling";"Asymmetric localization of PCP proteins";"GLI3 is processed to GLI3R by the proteasome";"Ub-specific processing proteases";"Degradation of beta-catenin by the destruction complex";"Regulation of RUNX2 expression and activity";"Ubiquitin-dependent degradation of Cyclin D";"Regulation of expression of SLITs and ROBOs";"Orc1 removal from chromatin";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"ABC-family proteins mediated transport";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Vif-mediated degradation of APOBEC3G";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Degradation of DVL";"Separation of Sister Chromatids";"Interleukin-1 signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Downstream TCR signaling";"Regulation of RAS by GAPs";"Hedgehog ligand biogenesis";"Regulation of RUNX3 expression and activity";"Neddylation";"FCERI mediated NF-kB activation";"CLEC7A (Dectin-1) signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Activation of NF-kappaB in B cells";"APC/C:Cdc20 mediated degradation of Securin";"Regulation of PTEN stability and activity";"Negative regulation of NOTCH4 signaling";"CDT1 association with the CDC6:ORC:origin complex";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"CDK-mediated phosphorylation and removal of Cdc6";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"NIK-->noncanonical NF-kB signaling";"SCF-beta-TrCP mediated degradation of Emi1";"Degradation of AXIN";"G2/M Checkpoints";"Defective CFTR causes cystic fibrosis";"Regulation of ornithine decarboxylase (ODC)";"ER-Phagosome pathway";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Degradation of GLI2 by the proteasome";"SCF(Skp2)-mediated degradation of p27/p21";"Autodegradation of Cdh1 by Cdh1:APC/C"
Medex_00020415-RA	1	Reactome: R-HSA-429958	"mRNA decay by 3' to 5' exoribonuclease"
Medex_00054296-RA	2	Reactome: R-HSA-1660662;Reactome: R-HSA-390471	"Glycosphingolipid metabolism";"Association of TriC/CCT with target proteins during biosynthesis"
Medex_00011742-RA	2	Reactome: R-HSA-6804115;Reactome: R-HSA-429947	"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Deadenylation of mRNA"
Medex_00087444-RA	5	KEGG: 00760+6.3.4.21;Reactome: R-HSA-1368108;MetaCyc: PWY-5381;Reactome: R-HSA-6798695;Reactome: R-HSA-197264	"Nicotinate and nicotinamide metabolism";"BMAL1:CLOCK,NPAS2 activates circadian gene expression";"Pyridine nucleotide cycling (plants)";"Neutrophil degranulation";"Nicotinamide salvaging"
Medex_00058310-RA	1	Reactome: R-HSA-264876	"Insulin processing"
Medex_00060469-RA	4	KEGG: 00730+2.8.1.7;Reactome: R-HSA-947581;MetaCyc: PWY-7250;Reactome: R-HSA-1362409	"Thiamine metabolism";"Molybdenum cofactor biosynthesis";"[2Fe-2S] iron-sulfur cluster biosynthesis";"Mitochondrial iron-sulfur cluster biogenesis"
Medex_00038171-RA	5	MetaCyc: PWY-4981;Reactome: R-HSA-8964539;KEGG: 00330+1.5.1.2;MetaCyc: PWY-6344;MetaCyc: PWY-3341	"L-proline biosynthesis II (from arginine)";"Glutamate and glutamine metabolism";"Arginine and proline metabolism";"L-ornithine degradation II (Stickland reaction)";"L-proline biosynthesis III (from L-ornithine)"
Medex_00017425-RA	2	Reactome: R-HSA-8856825;Reactome: R-HSA-8856828	"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis"
Medex_00053810-RA	4	Reactome: R-HSA-5689603;Reactome: R-HSA-3214847;KEGG: 00514+2.4.1.255;MetaCyc: PWY-7437	"UCH proteinases";"HATs acetylate histones";"Other types of O-glycan biosynthesis";"Protein O-[N-acetyl]-glucosylation"
Medex_00022602-RA	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
Medex_00004328-RA	19	Reactome: R-HSA-8963901;Reactome: R-HSA-3000480;Reactome: R-HSA-8856828;Reactome: R-HSA-8964041;Reactome: R-HSA-8963888;Reactome: R-HSA-975634;Reactome: R-HSA-3000471;Reactome: R-HSA-381426;Reactome: R-HSA-202733;Reactome: R-HSA-3000497;Reactome: R-HSA-8957275;Reactome: R-HSA-8964038;Reactome: R-HSA-8964046;Reactome: R-HSA-432142;Reactome: R-HSA-8866423;Reactome: R-HSA-3000484;Reactome: R-HSA-5686938;Reactome: R-HSA-8964026;Reactome: R-HSA-8856825	"Chylomicron remodeling";"Scavenging by Class A Receptors";"Clathrin-mediated endocytosis";"LDL remodeling";"Chylomicron assembly";"Retinoid metabolism and transport";"Scavenging by Class B Receptors";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"Cell surface interactions at the vascular wall";"Scavenging by Class H Receptors";"Post-translational protein phosphorylation";"LDL clearance";"VLDL clearance";"Platelet sensitization by LDL";"VLDL assembly";"Scavenging by Class F Receptors";"Regulation of TLR by endogenous ligand";"Chylomicron clearance";"Cargo recognition for clathrin-mediated endocytosis"
Medex_00073115-RA	3	KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16	"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway"
Medex_00067996-RA	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
Medex_00007758-RA	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
Medex_00021285-RA	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
Medex_00011452-RA	2	Reactome: R-HSA-6783984;Reactome: R-HSA-389661	"Glycine degradation";"Glyoxylate metabolism and glycine degradation"
Medex_00045719-RA	3	MetaCyc: PWY-6348;KEGG: 00730+3.1.3.2;KEGG: 00740+3.1.3.2	"Phosphate acquisition";"Thiamine metabolism";"Riboflavin metabolism"
Medex_00095090-RA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
Medex_00020106-RA	1	Reactome: R-HSA-6784531	"tRNA processing in the nucleus"
Medex_00006507-RA	3	MetaCyc: PWY-4041;Reactome: R-HSA-174403;KEGG: 00480+4.3.2.9	"Gamma-glutamyl cycle";"Glutathione synthesis and recycling";"Glutathione metabolism"
Medex_00027984-RA	2	Reactome: R-HSA-203927;Reactome: R-HSA-8986944	"MicroRNA (miRNA) biogenesis";"Transcriptional Regulation by MECP2"
Medex_00084934-RA	10	Reactome: R-HSA-2644606;Reactome: R-HSA-2122947;Reactome: R-HSA-9013695;Reactome: R-HSA-2197563;Reactome: R-HSA-210744;Reactome: R-HSA-8941856;Reactome: R-HSA-350054;Reactome: R-HSA-1912408;Reactome: R-HSA-2894862;Reactome: R-HSA-9013508	"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH1 Intracellular Domain Regulates Transcription";"NOTCH4 Intracellular Domain Regulates Transcription";"NOTCH2 intracellular domain regulates transcription";"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"RUNX3 regulates NOTCH signaling";"Notch-HLH transcription pathway";"Pre-NOTCH Transcription and Translation";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"NOTCH3 Intracellular Domain Regulates Transcription"
Medex_00000001-RA	5	Reactome: R-HSA-6798695;Reactome: R-HSA-2132295;Reactome: R-HSA-4085001;Reactome: R-HSA-1660662;Reactome: R-HSA-4341670	"Neutrophil degranulation";"MHC class II antigen presentation";"Sialic acid metabolism";"Glycosphingolipid metabolism";"Defective NEU1 causes sialidosis"
Medex_00046353-RA	1	Reactome: R-HSA-6799198	"Complex I biogenesis"
Medex_00058948-RA	14	MetaCyc: PWY-6433;MetaCyc: PWY-7036;MetaCyc: PWY-7619;MetaCyc: PWY-7602;MetaCyc: PWY-7035;Reactome: R-HSA-75876;MetaCyc: PWY-5972;MetaCyc: PWY-7724;MetaCyc: PWY-7601;MetaCyc: PWY-6598;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7725;MetaCyc: PWY-5080;MetaCyc: PWY-8041	"Hydroxylated fatty acid biosynthesis (plants)";"Very long chain fatty acid biosynthesis II";"Juniperonate biosynthesis";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"(9Z)-tricosene biosynthesis";"Synthesis of very long-chain fatty acyl-CoAs";"Stearate biosynthesis I (animals)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Sciadonate biosynthesis";"Fatty acid elongation";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Very long chain fatty acid biosynthesis I";"Ultra-long-chain fatty acid biosynthesis"
Medex_00040261-RA	1	Reactome: R-HSA-211945	"Phase I - Functionalization of compounds"
Medex_00050324-RA	2	Reactome: R-HSA-429947;Reactome: R-HSA-6804115	"Deadenylation of mRNA";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"
Medex_00051515-RA	13	KEGG: 00603+3.2.1.52;MetaCyc: PWY-6902;MetaCyc: PWY-7883;Reactome: R-HSA-2160916;KEGG: 00531+3.2.1.52;KEGG: 00520+3.2.1.52;MetaCyc: PWY-7822;KEGG: 00513+3.2.1.52;KEGG: 00511+3.2.1.52;Reactome: R-HSA-2022857;KEGG: 00604+3.2.1.52;Reactome: R-HSA-1660662;Reactome: R-HSA-2024101	"Glycosphingolipid biosynthesis - globo and isoglobo series";"Chitin degradation II (Vibrio)";"Anhydromuropeptides recycling II";"Hyaluronan uptake and degradation";"Glycosaminoglycan degradation";"Amino sugar and nucleotide sugar metabolism";"Chitin degradation III (Serratia)";"Various types of N-glycan biosynthesis";"Other glycan degradation";"Keratan sulfate degradation";"Glycosphingolipid biosynthesis - ganglio series";"Glycosphingolipid metabolism";"CS/DS degradation"
Medex_00018666-RA	1	Reactome: R-HSA-6811440	"Retrograde transport at the Trans-Golgi-Network"
Medex_00093503-RA	2	Reactome: R-HSA-381038;Reactome: R-HSA-1632852	"XBP1(S) activates chaperone genes";"Macroautophagy"
Medex_00065178-RA	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
Medex_00048160-RA	3	Reactome: R-HSA-2142691;Reactome: R-HSA-5423646;MetaCyc: PWY-7533	"Synthesis of Leukotrienes (LT) and Eoxins (EX)";"Aflatoxin activation and detoxification";"Gliotoxin biosynthesis"
Medex_00045571-RA	1	Reactome: R-HSA-8849932	"Synaptic adhesion-like molecules"
Medex_00095058-RA	2	Reactome: R-HSA-194840;Reactome: R-HSA-8876198	"Rho GTPase cycle";"RAB GEFs exchange GTP for GDP on RABs"
Medex_00053157-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00088233-RA	2	Reactome: R-HSA-72165;Reactome: R-HSA-72163	"mRNA Splicing - Minor Pathway";"mRNA Splicing - Major Pathway"
Medex_00014560-RA	3	Reactome: R-HSA-212436;Reactome: R-HSA-381340;Reactome: R-HSA-1989781	"Generic Transcription Pathway";"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression"
Medex_00023109-RA	11	Reactome: R-HSA-2151201;Reactome: R-HSA-383280;Reactome: R-HSA-212436;Reactome: R-HSA-1368108;Reactome: R-HSA-2426168;Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-400253;Reactome: R-HSA-1368082;Reactome: R-HSA-400206;Reactome: R-HSA-9018519	"Transcriptional activation of mitochondrial biogenesis";"Nuclear Receptor transcription pathway";"Generic Transcription Pathway";"BMAL1:CLOCK,NPAS2 activates circadian gene expression";"Activation of gene expression by SREBF (SREBP)";"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"Circadian Clock";"RORA activates gene expression";"Regulation of lipid metabolism by PPARalpha";"Estrogen-dependent gene expression"
Medex_00077642-RA	4	MetaCyc: PWY-7219;Reactome: R-HSA-499943;KEGG: 00730+2.7.4.3;KEGG: 00230+2.7.4.3	"Adenosine ribonucleotides de novo biosynthesis";"Interconversion of nucleotide di- and triphosphates";"Thiamine metabolism";"Purine metabolism"
Medex_00054859-RA	2	Reactome: R-HSA-8856828;Reactome: R-HSA-8856825	"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis"
Medex_00083261-RA	2	Reactome: R-HSA-1660662;Reactome: R-HSA-390471	"Glycosphingolipid metabolism";"Association of TriC/CCT with target proteins during biosynthesis"
Medex_00020201-RA	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
Medex_00031951-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Medex_00052355-RA	27	Reactome: R-HSA-165054;Reactome: R-HSA-1169408;Reactome: R-HSA-168333;Reactome: R-HSA-180746;Reactome: R-HSA-159227;Reactome: R-HSA-159231;Reactome: R-HSA-3371453;Reactome: R-HSA-4615885;Reactome: R-HSA-159230;Reactome: R-HSA-5578749;Reactome: R-HSA-168276;Reactome: R-HSA-3232142;Reactome: R-HSA-3301854;Reactome: R-HSA-180910;Reactome: R-HSA-168271;Reactome: R-HSA-170822;Reactome: R-HSA-4570464;Reactome: R-HSA-4085377;Reactome: R-HSA-4551638;Reactome: R-HSA-9609690;Reactome: R-HSA-5619107;Reactome: R-HSA-9610379;Reactome: R-HSA-168325;Reactome: R-HSA-191859;Reactome: R-HSA-159236;Reactome: R-HSA-3108214;Reactome: R-HSA-6784531	"Rev-mediated nuclear export of HIV RNA";"ISG15 antiviral mechanism";"NEP/NS2 Interacts with the Cellular Export Machinery";"Nuclear import of Rev protein";"Transport of the SLBP independent Mature mRNA";"Transport of Mature mRNA Derived from an Intronless Transcript";"Regulation of HSF1-mediated heat shock response";"SUMOylation of DNA replication proteins";"Transport of the SLBP Dependant Mature mRNA";"Transcriptional regulation by small RNAs";"NS1 Mediated Effects on Host Pathways";"SUMOylation of ubiquitinylation proteins";"Nuclear Pore Complex (NPC) Disassembly";"Vpr-mediated nuclear import of PICs";"Transport of Ribonucleoproteins into the Host Nucleus";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"SUMOylation of RNA binding proteins";"SUMOylation of SUMOylation proteins";"SUMOylation of chromatin organization proteins";"HCMV Early Events";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"HCMV Late Events";"Viral Messenger RNA Synthesis";"snRNP Assembly";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"SUMOylation of DNA damage response and repair proteins";"tRNA processing in the nucleus"
Medex_00018878-RA	5	MetaCyc: PWY-5653;MetaCyc: PWY-5381;MetaCyc: PWY-7761;KEGG: 00760+2.7.7.18;Reactome: R-HSA-196807	"NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde";"Pyridine nucleotide cycling (plants)";"NAD salvage pathway II (PNC IV cycle)";"Nicotinate and nicotinamide metabolism";"Nicotinate metabolism"
Medex_00091674-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Medex_00021086-RA	3	Reactome: R-HSA-1799339;Reactome: R-HSA-1236974;Reactome: R-HSA-9609523	"SRP-dependent cotranslational protein targeting to membrane";"ER-Phagosome pathway";"Insertion of tail-anchored proteins into the endoplasmic reticulum membrane"
Medex_00085216-RA	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
Medex_00006505-RA	2	KEGG: 00970+6.1.1.4;Reactome: R-HSA-379726	"Aminoacyl-tRNA biosynthesis";"Mitochondrial tRNA aminoacylation"
Medex_00051408-RA	1	Reactome: R-HSA-420029	"Tight junction interactions"
Medex_00064289-RA	1	Reactome: R-HSA-3299685	"Detoxification of Reactive Oxygen Species"
Medex_00022945-RA	2	Reactome: R-HSA-429947;Reactome: R-HSA-6804115	"Deadenylation of mRNA";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"
Medex_00086535-RA	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
Medex_00005264-RA	1	Reactome: R-HSA-9033241	"Peroxisomal protein import"
Medex_00032263-RA	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
Medex_00062630-RA	2	Reactome: R-HSA-2022854;Reactome: R-HSA-975577	"Keratan sulfate biosynthesis";"N-Glycan antennae elongation"
Medex_00056673-RA	5	Reactome: R-HSA-3928662;Reactome: R-HSA-8849471;Reactome: R-HSA-5218921;Reactome: R-HSA-5658442;Reactome: R-HSA-186763	"EPHB-mediated forward signaling";"PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases";"VEGFR2 mediated cell proliferation";"Regulation of RAS by GAPs";"Downstream signal transduction"
Medex_00103697-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Medex_00035940-RA	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
Medex_00007220-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Medex_00042952-RA	1	Reactome: R-HSA-8949664	"Processing of SMDT1"
Medex_00067161-RA	3	Reactome: R-HSA-2142691;Reactome: R-HSA-5423646;MetaCyc: PWY-7533	"Synthesis of Leukotrienes (LT) and Eoxins (EX)";"Aflatoxin activation and detoxification";"Gliotoxin biosynthesis"
Medex_00076314-RA	6	Reactome: R-HSA-2426168;MetaCyc: PWY-922;KEGG: 00900+4.1.1.33;MetaCyc: PWY-7391;Reactome: R-HSA-191273;Reactome: R-HSA-446199	"Activation of gene expression by SREBF (SREBP)";"Mevalonate pathway I";"Terpenoid backbone biosynthesis";"Isoprene biosynthesis II (engineered)";"Cholesterol biosynthesis";"Synthesis of Dolichyl-phosphate"
Medex_00012717-RA	3	MetaCyc: PWY-6348;KEGG: 00740+3.1.3.2;KEGG: 00730+3.1.3.2	"Phosphate acquisition";"Riboflavin metabolism";"Thiamine metabolism"
Medex_00029265-RA	1	Reactome: R-HSA-5358493	"Synthesis of diphthamide-EEF2"
Medex_00066283-RA	6	Reactome: R-HSA-400253;Reactome: R-HSA-163560;KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16;Reactome: R-HSA-2173788;KEGG: 04660+3.1.3.16	"Circadian Clock";"Triglyceride catabolism";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation";"Downregulation of TGF-beta receptor signaling";"T cell receptor signaling pathway"
Medex_00019349-RA	27	Reactome: R-HSA-1169408;Reactome: R-HSA-168333;Reactome: R-HSA-165054;Reactome: R-HSA-159231;Reactome: R-HSA-180746;Reactome: R-HSA-159227;Reactome: R-HSA-4615885;Reactome: R-HSA-159230;Reactome: R-HSA-3371453;Reactome: R-HSA-168276;Reactome: R-HSA-5578749;Reactome: R-HSA-168271;Reactome: R-HSA-180910;Reactome: R-HSA-3232142;Reactome: R-HSA-3301854;Reactome: R-HSA-4085377;Reactome: R-HSA-170822;Reactome: R-HSA-4570464;Reactome: R-HSA-5619107;Reactome: R-HSA-9610379;Reactome: R-HSA-9609690;Reactome: R-HSA-4551638;Reactome: R-HSA-3108214;Reactome: R-HSA-6784531;Reactome: R-HSA-168325;Reactome: R-HSA-159236;Reactome: R-HSA-191859	"ISG15 antiviral mechanism";"NEP/NS2 Interacts with the Cellular Export Machinery";"Rev-mediated nuclear export of HIV RNA";"Transport of Mature mRNA Derived from an Intronless Transcript";"Nuclear import of Rev protein";"Transport of the SLBP independent Mature mRNA";"SUMOylation of DNA replication proteins";"Transport of the SLBP Dependant Mature mRNA";"Regulation of HSF1-mediated heat shock response";"NS1 Mediated Effects on Host Pathways";"Transcriptional regulation by small RNAs";"Transport of Ribonucleoproteins into the Host Nucleus";"Vpr-mediated nuclear import of PICs";"SUMOylation of ubiquitinylation proteins";"Nuclear Pore Complex (NPC) Disassembly";"SUMOylation of SUMOylation proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"SUMOylation of RNA binding proteins";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"HCMV Late Events";"HCMV Early Events";"SUMOylation of chromatin organization proteins";"SUMOylation of DNA damage response and repair proteins";"tRNA processing in the nucleus";"Viral Messenger RNA Synthesis";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"snRNP Assembly"
Medex_00007585-RA	2	Reactome: R-HSA-2514859;KEGG: 00900+2.5.1.58	"Inactivation, recovery and regulation of the phototransduction cascade";"Terpenoid backbone biosynthesis"
Medex_00045816-RA	3	Reactome: R-HSA-5689880;Reactome: R-HSA-201722;Reactome: R-HSA-3214847	"Ub-specific processing proteases";"Formation of the beta-catenin:TCF transactivating complex";"HATs acetylate histones"
Medex_00076950-RA	2	Reactome: R-HSA-5576892;Reactome: R-HSA-5576893	"Phase 0 - rapid depolarisation";"Phase 2 - plateau phase"
Medex_00058261-RA	5	Reactome: R-HSA-189451;MetaCyc: PWY-5188;MetaCyc: PWY-5189;Reactome: R-HSA-6798695;KEGG: 00860+4.2.1.24	"Heme biosynthesis";"Tetrapyrrole biosynthesis I (from glutamate)";"Tetrapyrrole biosynthesis II (from glycine)";"Neutrophil degranulation";"Porphyrin and chlorophyll metabolism"
Medex_00060793-RA	3	Reactome: R-HSA-6798695;Reactome: R-HSA-983231;Reactome: R-HSA-164944	"Neutrophil degranulation";"Factors involved in megakaryocyte development and platelet production";"Nef and signal transduction"
Medex_00048932-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Medex_00022241-RA	2	KEGG: 00520+5.4.2.10;MetaCyc: PWY-6749	"Amino sugar and nucleotide sugar metabolism";"CMP-legionaminate biosynthesis I"
Medex_00009122-RA	1	Reactome: R-HSA-6784531	"tRNA processing in the nucleus"
Medex_00036980-RA	1	Reactome: R-HSA-1474228	"Degradation of the extracellular matrix"
Medex_00046664-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Medex_00091242-RA	7	MetaCyc: PWY-7039;MetaCyc: PWY-6351;Reactome: R-HSA-1855204;KEGG: 00562+3.1.4.11;MetaCyc: PWY-6367;KEGG: 04070+3.1.4.11;MetaCyc: PWY-8052	"Phosphatidate metabolism, as a signaling molecule";"D-myo-inositol (1,4,5)-trisphosphate biosynthesis";"Synthesis of IP3 and IP4 in the cytosol";"Inositol phosphate metabolism";"D-myo-inositol-5-phosphate metabolism";"Phosphatidylinositol signaling system";"2-arachidonoylglycerol biosynthesis"
Medex_00027265-RA	7	MetaCyc: PWY-4702;KEGG: 00521+3.1.3.25;MetaCyc: PWY-6363;Reactome: R-HSA-1855183;MetaCyc: PWY-2301;KEGG: 00562+3.1.3.25;KEGG: 04070+3.1.3.25	"Phytate degradation I";"Streptomycin biosynthesis";"D-myo-inositol (1,4,5)-trisphosphate degradation";"Synthesis of IP2, IP, and Ins in the cytosol";"Myo-inositol biosynthesis";"Inositol phosphate metabolism";"Phosphatidylinositol signaling system"
Medex_00009874-RA	6	Reactome: R-HSA-5693565;Reactome: R-HSA-8939211;KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;Reactome: R-HSA-5675221	"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"ESR-mediated signaling";"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"Negative regulation of MAPK pathway"
Medex_00009474-RA	11	MetaCyc: PWY-6453;KEGG: 00561+3.1.3.4;MetaCyc: PWY-8051;MetaCyc: PWY-8052;MetaCyc: PWY-8053;KEGG: 00564+3.1.3.4;MetaCyc: PWY-7782;KEGG: 00600+3.1.3.4;KEGG: 00565+3.1.3.4;MetaCyc: PWY-8055;Reactome: R-HSA-2029485	"Stigma estolide biosynthesis";"Glycerolipid metabolism";"Anandamide biosynthesis I";"2-arachidonoylglycerol biosynthesis";"Anandamide biosynthesis II";"Glycerophospholipid metabolism";"Plasmalogen biosynthesis";"Sphingolipid metabolism";"Ether lipid metabolism";"Palmitoyl ethanolamide biosynthesis";"Role of phospholipids in phagocytosis"
Medex_00033268-RA	1	KEGG: 00970+6.1.1.7	"Aminoacyl-tRNA biosynthesis"
Medex_00073147-RA	9	Reactome: R-HSA-674695;Reactome: R-HSA-6807505;Reactome: R-HSA-73776;Reactome: R-HSA-75953;Reactome: R-HSA-167161;Reactome: R-HSA-167172;Reactome: R-HSA-73779;Reactome: R-HSA-167162;Reactome: R-HSA-76042	"RNA Polymerase II Pre-transcription Events";"RNA polymerase II transcribes snRNA genes";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Transcription Initiation";"HIV Transcription Initiation";"Transcription of the HIV genome";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Initiation And Promoter Clearance"
Medex_00067690-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00020245-RA	1	Reactome: R-HSA-204005	"COPII-mediated vesicle transport"
Medex_00013969-RA	4	Reactome: R-HSA-4655427;Reactome: R-HSA-212300;Reactome: R-HSA-5334118;KEGG: 00270+2.1.1.37	"SUMOylation of DNA methylation proteins";"PRC2 methylates histones and DNA";"DNA methylation";"Cysteine and methionine metabolism"
Medex_00041373-RA	5	Reactome: R-HSA-9610379;Reactome: R-HSA-174490;Reactome: R-HSA-9615710;Reactome: R-HSA-917729;Reactome: R-HSA-162588	"HCMV Late Events";"Membrane binding and targetting of GAG proteins";"Late endosomal microautophagy";"Endosomal Sorting Complex Required For Transport (ESCRT)";"Budding and maturation of HIV virion"
Medex_00091152-RA	3	KEGG: 00511+3.2.1.51;MetaCyc: PWY-6807;Reactome: R-HSA-6798695	"Other glycan degradation";"Xyloglucan degradation II (exoglucanase)";"Neutrophil degranulation"
Medex_00030946-RA	1	Reactome: R-HSA-390522	"Striated Muscle Contraction"
Medex_00062939-RA	3	MetaCyc: PWY-6348;KEGG: 00740+3.1.3.2;KEGG: 00730+3.1.3.2	"Phosphate acquisition";"Riboflavin metabolism";"Thiamine metabolism"
Medex_00099099-RA	6	Reactome: R-HSA-9640463;MetaCyc: PWY-5884;KEGG: 00073+1.2.1.84;MetaCyc: PWY-7782;MetaCyc: PWY-7656;MetaCyc: PWY-6733	"Wax biosynthesis";"Wax esters biosynthesis I";"Cutin, suberine and wax biosynthesis";"Plasmalogen biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Sporopollenin precursors biosynthesis"
Medex_00028387-RA	7	KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1	"Thermogenesis";"Relaxin signaling pathway";"Human cytomegalovirus infection";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"PI3K-Akt signaling pathway";"mTOR signaling pathway"
Medex_00005437-RA	6	Reactome: R-HSA-6791226;Reactome: R-HSA-429958;Reactome: R-HSA-380994;Reactome: R-HSA-450604;Reactome: R-HSA-450385;Reactome: R-HSA-450513	"Major pathway of rRNA processing in the nucleolus and cytosol";"mRNA decay by 3' to 5' exoribonuclease";"ATF4 activates genes in response to endoplasmic reticulum stress";"KSRP (KHSRP) binds and destabilizes mRNA";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA"
Medex_00048927-RA	3	Reactome: R-HSA-3232118;Reactome: R-HSA-4090294;Reactome: R-HSA-3899300	"SUMOylation of transcription factors";"SUMOylation of intracellular receptors";"SUMOylation of transcription cofactors"
Medex_00025163-RA	4	Reactome: R-HSA-379726;Reactome: R-HSA-379716;Reactome: R-HSA-2408522;KEGG: 00970+6.1.1.6	"Mitochondrial tRNA aminoacylation";"Cytosolic tRNA aminoacylation";"Selenoamino acid metabolism";"Aminoacyl-tRNA biosynthesis"
Medex_00004109-RA	3	Reactome: R-HSA-5663213;Reactome: R-HSA-4420097;Reactome: R-HSA-2029482	"RHO GTPases Activate WASPs and WAVEs";"VEGFA-VEGFR2 Pathway";"Regulation of actin dynamics for phagocytic cup formation"
Medex_00095378-RA	5	KEGG: 00564+2.7.7.41;MetaCyc: PWY-5981;MetaCyc: PWY-5667;KEGG: 04070+2.7.7.41;MetaCyc: PWY-7817	"Glycerophospholipid metabolism";"CDP-diacylglycerol biosynthesis III";"CDP-diacylglycerol biosynthesis I";"Phosphatidylinositol signaling system";"Type I lipoteichoic acid biosynthesis (S. aureus)"
Medex_00048951-RA	7	KEGG: 00220+3.5.1.2;Reactome: R-HSA-210500;MetaCyc: PWY-5921;KEGG: 00471+3.5.1.2;KEGG: 00250+3.5.1.2;Reactome: R-HSA-8964539;Reactome: R-HSA-5628897	"Arginine biosynthesis";"Glutamate Neurotransmitter Release Cycle";"Glutaminyl-trnagln biosynthesis via transamidation";"D-Glutamine and D-glutamate metabolism";"Alanine, aspartate and glutamate metabolism";"Glutamate and glutamine metabolism";"TP53 Regulates Metabolic Genes"
Medex_00023742-RA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
Medex_00055784-RA	2	Reactome: R-HSA-168276;Reactome: R-HSA-1169408	"NS1 Mediated Effects on Host Pathways";"ISG15 antiviral mechanism"
Medex_00005860-RA	2	MetaCyc: PWY-6788;KEGG: 00500+3.2.1.4	"Cellulose degradation II (fungi)";"Starch and sucrose metabolism"
Medex_00035757-RA	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
Medex_00035018-RA	1	KEGG: 00760+2.3.1.286	"Nicotinate and nicotinamide metabolism"
Medex_00002495-RA	1	Reactome: R-HSA-6809371	"Formation of the cornified envelope"
Medex_00037543-RA	22	Reactome: R-HSA-5467340;Reactome: R-HSA-2467813;Reactome: R-HSA-5467337;Reactome: R-HSA-9648025;Reactome: R-HSA-68877;Reactome: R-HSA-5358752;Reactome: R-HSA-196299;Reactome: R-HSA-5663220;Reactome: R-HSA-5339716;Reactome: R-HSA-5675221;Reactome: R-HSA-5358747;Reactome: R-HSA-2500257;Reactome: R-HSA-5673000;Reactome: R-HSA-5467348;Reactome: R-HSA-5358749;Reactome: R-HSA-5358751;Reactome: R-HSA-6811558;Reactome: R-HSA-389513;Reactome: R-HSA-195253;Reactome: R-HSA-432142;Reactome: R-HSA-4641262;Reactome: R-HSA-141444	"AXIN missense mutants destabilize the destruction complex";"Separation of Sister Chromatids";"APC truncation mutants have impaired AXIN binding";"EML4 and NUDC in mitotic spindle formation";"Mitotic Prometaphase";"T41 mutants of beta-catenin aren't phosphorylated";"Beta-catenin phosphorylation cascade";"RHO GTPases Activate Formins";"Misspliced GSK3beta mutants stabilize beta-catenin";"Negative regulation of MAPK pathway";"S33 mutants of beta-catenin aren't phosphorylated";"Resolution of Sister Chromatid Cohesion";"RAF activation";"Truncations of AMER1 destabilize the destruction complex";"S37 mutants of beta-catenin aren't phosphorylated";"S45 mutants of beta-catenin aren't phosphorylated";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"CTLA4 inhibitory signaling";"Degradation of beta-catenin by the destruction complex";"Platelet sensitization by LDL";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"
Medex_00008560-RA	2	Reactome: R-HSA-3295583;Reactome: R-HSA-418890	"TRP channels";"Role of second messengers in netrin-1 signaling"
Medex_00045718-RA	1	Reactome: R-HSA-499943	"Interconversion of nucleotide di- and triphosphates"
Medex_00046262-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00033115-RA	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
Medex_00005297-RA	1	Reactome: R-HSA-376172	"DSCAM interactions"
Medex_00045355-RA	6	KEGG: 00073+1.2.1.84;MetaCyc: PWY-7656;MetaCyc: PWY-7782;MetaCyc: PWY-6733;MetaCyc: PWY-5884;Reactome: R-HSA-9640463	"Cutin, suberine and wax biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Plasmalogen biosynthesis";"Sporopollenin precursors biosynthesis";"Wax esters biosynthesis I";"Wax biosynthesis"
Medex_00033056-RA	3	Reactome: R-HSA-674695;Reactome: R-HSA-75955;Reactome: R-HSA-112382	"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Elongation";"Formation of RNA Pol II elongation complex"
Medex_00028876-RA	5	Reactome: R-HSA-2122947;Reactome: R-HSA-2644606;Reactome: R-HSA-3214815;Reactome: R-HSA-2894862;Reactome: R-HSA-350054	"NOTCH1 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"HDACs deacetylate histones";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Notch-HLH transcription pathway"
Medex_00007475-RA	7	MetaCyc: PWY-5466;MetaCyc: PWY-7214;MetaCyc: PWY-7445;KEGG: 00940+1.11.1.7;MetaCyc: PWY-5461;MetaCyc: PWY-6824;MetaCyc: PWY-5469	"Matairesinol biosynthesis";"Baicalein degradation (hydrogen peroxide detoxification)";"Luteolin triglucuronide degradation";"Phenylpropanoid biosynthesis";"Betanidin degradation";"Justicidin B biosynthesis";"Sesamin biosynthesis"
Medex_00034888-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Medex_00043611-RA	9	Reactome: R-HSA-73776;Reactome: R-HSA-674695;Reactome: R-HSA-167172;Reactome: R-HSA-75953;Reactome: R-HSA-167161;Reactome: R-HSA-6804756;Reactome: R-HSA-73779;Reactome: R-HSA-76042;Reactome: R-HSA-167162	"RNA Polymerase II Promoter Escape";"RNA Polymerase II Pre-transcription Events";"Transcription of the HIV genome";"RNA Polymerase II Transcription Initiation";"HIV Transcription Initiation";"Regulation of TP53 Activity through Phosphorylation";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II HIV Promoter Escape"
Medex_00022078-RA	15	Reactome: R-HSA-1266695;Reactome: R-HSA-114604;Reactome: R-HSA-912526;Reactome: R-HSA-6811558;Reactome: R-HSA-1660499;Reactome: R-HSA-9009391;Reactome: R-HSA-512988;Reactome: R-HSA-1257604;Reactome: R-HSA-8853659;Reactome: R-HSA-1433557;Reactome: R-HSA-2219530;Reactome: R-HSA-389357;Reactome: R-HSA-912631;Reactome: R-HSA-388841;Reactome: R-HSA-416476	"Interleukin-7 signaling";"GPVI-mediated activation cascade";"Interleukin receptor SHC signaling";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"Synthesis of PIPs at the plasma membrane";"Extra-nuclear estrogen signaling";"Interleukin-3, Interleukin-5 and GM-CSF signaling";"PIP3 activates AKT signaling";"RET signaling";"Signaling by SCF-KIT";"Constitutive Signaling by Aberrant PI3K in Cancer";"CD28 dependent PI3K/Akt signaling";"Regulation of signaling by CBL";"Costimulation by the CD28 family";"G alpha (q) signalling events"
Medex_00046212-RA	3	KEGG: 00643+3.7.1.2;Reactome: R-HSA-8963684;KEGG: 00350+3.7.1.2	"Styrene degradation";"Tyrosine catabolism";"Tyrosine metabolism"
Medex_00026625-RA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
Medex_00025730-RA	3	MetaCyc: PWY-6369;KEGG: 04070+2.7.4.24+2.7.4.21;Reactome: R-HSA-1855167	"Inositol diphosphates biosynthesis";"Phosphatidylinositol signaling system";"Synthesis of pyrophosphates in the cytosol"
Medex_00068838-RA	3	KEGG: 00970+6.1.1.4;Reactome: R-HSA-2408522;Reactome: R-HSA-379716	"Aminoacyl-tRNA biosynthesis";"Selenoamino acid metabolism";"Cytosolic tRNA aminoacylation"
Medex_00065228-RA	1	Reactome: R-HSA-83936	"Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"
Medex_00008479-RA	1	Reactome: R-HSA-1296052	"Ca2+ activated K+ channels"
Medex_00101630-RA	3	MetaCyc: PWY-7426;KEGG: 00510+2.4.1.144;Reactome: R-HSA-975574	"Complex N-linked glycan biosynthesis (vertebrates)";"N-Glycan biosynthesis";"Reactions specific to the hybrid N-glycan synthesis pathway"
Medex_00010984-RA	5	Reactome: R-HSA-5689901;Reactome: R-HSA-5693571;Reactome: R-HSA-5693565;Reactome: R-HSA-69473;Reactome: R-HSA-5693607	"Metalloprotease DUBs";"Nonhomologous End-Joining (NHEJ)";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"G2/M DNA damage checkpoint";"Processing of DNA double-strand break ends"
Medex_00038039-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Medex_00057947-RA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Medex_00012209-RA	57	Reactome: R-HSA-5676590;Reactome: R-HSA-1234176;Reactome: R-HSA-5362768;Reactome: R-HSA-69017;Reactome: R-HSA-69601;Reactome: R-HSA-8948751;Reactome: R-HSA-68827;Reactome: R-HSA-9604323;Reactome: R-HSA-69481;Reactome: R-HSA-5678895;Reactome: R-HSA-350562;Reactome: R-HSA-4641257;Reactome: R-HSA-174113;Reactome: R-HSA-2871837;Reactome: R-HSA-8951664;Reactome: R-HSA-174154;Reactome: R-HSA-1169091;Reactome: R-HSA-5607764;Reactome: R-HSA-174184;Reactome: R-HSA-174084;Reactome: R-HSA-187577;Reactome: R-HSA-5610783;Reactome: R-HSA-8854050;Reactome: R-HSA-1236974;Reactome: R-HSA-5689880;Reactome: R-HSA-5610785;Reactome: R-HSA-4608870;Reactome: R-HSA-5668541;Reactome: R-HSA-5689603;Reactome: R-HSA-5687128;Reactome: R-HSA-75815;Reactome: R-HSA-8939902;Reactome: R-HSA-195253;Reactome: R-HSA-8852276;Reactome: R-HSA-5610780;Reactome: R-HSA-5607761;Reactome: R-HSA-174178;Reactome: R-HSA-5632684;Reactome: R-HSA-180534;Reactome: R-HSA-349425;Reactome: R-HSA-1236978;Reactome: R-HSA-9020702;Reactome: R-HSA-6798695;Reactome: R-HSA-8941858;Reactome: R-HSA-5358346;Reactome: R-HSA-5658442;Reactome: R-HSA-202424;Reactome: R-HSA-983168;Reactome: R-HSA-211733;Reactome: R-HSA-382556;Reactome: R-HSA-8939236;Reactome: R-HSA-68949;Reactome: R-HSA-9010553;Reactome: R-HSA-2467813;Reactome: R-HSA-4641258;Reactome: R-HSA-450408;Reactome: R-HSA-180585	"NIK-->noncanonical NF-kB signaling";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"CDK-mediated phosphorylation and removal of Cdc6";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Regulation of PTEN stability and activity";"CDT1 association with the CDC6:ORC:origin complex";"Negative regulation of NOTCH4 signaling";"G2/M Checkpoints";"Defective CFTR causes cystic fibrosis";"Regulation of ornithine decarboxylase (ODC)";"Degradation of AXIN";"SCF-beta-TrCP mediated degradation of Emi1";"FCERI mediated NF-kB activation";"Neddylation";"APC/C:Cdc20 mediated degradation of Securin";"Activation of NF-kappaB in B cells";"CLEC7A (Dectin-1) signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Autodegradation of Cdh1 by Cdh1:APC/C";"SCF(Skp2)-mediated degradation of p27/p21";"Degradation of GLI2 by the proteasome";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"ER-Phagosome pathway";"Ub-specific processing proteases";"GLI3 is processed to GLI3R by the proteasome";"Asymmetric localization of PCP proteins";"TNFR2 non-canonical NF-kB pathway";"UCH proteinases";"MAPK6/MAPK4 signaling";"Ubiquitin-dependent degradation of Cyclin D";"Regulation of RUNX2 expression and activity";"Degradation of beta-catenin by the destruction complex";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Degradation of GLI1 by the proteasome";"Dectin-1 mediated noncanonical NF-kB signaling";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Hedgehog 'on' state";"Vpu mediated degradation of CD4";"Autodegradation of the E3 ubiquitin ligase COP1";"Cross-presentation of soluble exogenous antigens (endosomes)";"Interleukin-1 signaling";"Neutrophil degranulation";"Regulation of RUNX3 expression and activity";"Hedgehog ligand biogenesis";"Regulation of RAS by GAPs";"Downstream TCR signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"ABC-family proteins mediated transport";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Orc1 removal from chromatin";"Regulation of expression of SLITs and ROBOs";"Separation of Sister Chromatids";"Degradation of DVL";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Vif-mediated degradation of APOBEC3G"
Medex_00077813-RA	6	Reactome: R-HSA-400253;Reactome: R-HSA-163560;Reactome: R-HSA-2173788;KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16	"Circadian Clock";"Triglyceride catabolism";"Downregulation of TGF-beta receptor signaling";"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation"
Medex_00093251-RA	6	KEGG: 00260+5.4.2.11;MetaCyc: PWY-8004;KEGG: 00010+5.4.2.11;MetaCyc: PWY-5484;KEGG: 00680+5.4.2.11;MetaCyc: PWY-1622	"Glycine, serine and threonine metabolism";"Entner-Doudoroff pathway I";"Glycolysis / Gluconeogenesis";"Glycolysis II (from fructose 6-phosphate)";"Methane metabolism";"Formaldehyde assimilation I (serine pathway)"
Medex_00047436-RA	14	MetaCyc: PWY-8053;MetaCyc: PWY-7417;KEGG: 00591+3.1.1.4;MetaCyc: PWY-7409;MetaCyc: PWY-8051;MetaCyc: PWY-6803;KEGG: 00565+3.1.1.4;Reactome: R-HSA-975634;KEGG: 00590+3.1.1.4;MetaCyc: PWY-7416;Reactome: R-HSA-1482788;MetaCyc: PWY-7783;KEGG: 00592+3.1.1.4;KEGG: 00564+3.1.1.4+3.1.1.5	"Anandamide biosynthesis II";"Phospholipid remodeling (phosphatidate, yeast)";"Linoleic acid metabolism";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Anandamide biosynthesis I";"Phosphatidylcholine acyl editing";"Ether lipid metabolism";"Retinoid metabolism and transport";"Arachidonic acid metabolism";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Acyl chain remodelling of PC";"Plasmalogen degradation";"alpha-Linolenic acid metabolism";"Glycerophospholipid metabolism"
Medex_00090525-RA	7	Reactome: R-HSA-2644606;Reactome: R-HSA-9013507;Reactome: R-HSA-2660826;Reactome: R-HSA-2979096;Reactome: R-HSA-2122948;Reactome: R-HSA-2691232;Reactome: R-HSA-2894862	"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Activated NOTCH1 Transmits Signal to the Nucleus";"Constitutive Signaling by NOTCH1 HD Domain Mutants";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants"
Medex_00033158-RA	2	Reactome: R-HSA-72165;Reactome: R-HSA-72163	"mRNA Splicing - Minor Pathway";"mRNA Splicing - Major Pathway"
Medex_00062547-RA	3	MetaCyc: PWY-7546;MetaCyc: PWY-6482;Reactome: R-HSA-5358493	"Diphthamide biosynthesis II (eukaryotes)";"Diphthamide biosynthesis I (archaea)";"Synthesis of diphthamide-EEF2"
Medex_00036888-RA	10	MetaCyc: PWY-4041;KEGG: 00460+2.3.2.2;MetaCyc: PWY-5826;KEGG: 00480+2.3.2.2+3.4.19.13;KEGG: 00430+2.3.2.2;MetaCyc: PWY-7559;MetaCyc: PWY-7112;MetaCyc: PWY-4061;MetaCyc: PWY-8001;MetaCyc: PWY-6842	"Gamma-glutamyl cycle";"Cyanoamino acid metabolism";"Hypoglycin biosynthesis";"Glutathione metabolism";"Taurine and hypotaurine metabolism";"Glutathione degradation (DUG pathway";"4-hydroxy-2-nonenal detoxification";"Glutathione-mediated detoxification I";"Felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis";"Glutathione-mediated detoxification II"
Medex_00006165-RA	17	Reactome: R-HSA-192823;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-156902;Reactome: R-HSA-72695;Reactome: R-HSA-72649;Reactome: R-HSA-72689;Reactome: R-HSA-6790901;Reactome: R-HSA-2408557;Reactome: R-HSA-975957;Reactome: R-HSA-9633012;Reactome: R-HSA-1799339;Reactome: R-HSA-72764;Reactome: R-HSA-975956;Reactome: R-HSA-72706;Reactome: R-HSA-6791226;Reactome: R-HSA-72702	"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Peptide chain elongation";"Formation of the ternary complex, and subsequently, the 43S complex";"Translation initiation complex formation";"Formation of a pool of free 40S subunits";"rRNA modification in the nucleus and cytosol";"Selenocysteine synthesis";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"SRP-dependent cotranslational protein targeting to membrane";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Major pathway of rRNA processing in the nucleolus and cytosol";"Ribosomal scanning and start codon recognition"
Medex_00076630-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00077905-RA	56	Reactome: R-HSA-5687128;Reactome: R-HSA-5689603;Reactome: R-HSA-5668541;Reactome: R-HSA-4608870;Reactome: R-HSA-5689880;Reactome: R-HSA-5610785;Reactome: R-HSA-195253;Reactome: R-HSA-8939902;Reactome: R-HSA-75815;Reactome: R-HSA-174178;Reactome: R-HSA-5607761;Reactome: R-HSA-8852276;Reactome: R-HSA-5610780;Reactome: R-HSA-1236978;Reactome: R-HSA-349425;Reactome: R-HSA-180534;Reactome: R-HSA-5632684;Reactome: R-HSA-9020702;Reactome: R-HSA-983168;Reactome: R-HSA-202424;Reactome: R-HSA-5658442;Reactome: R-HSA-5358346;Reactome: R-HSA-8941858;Reactome: R-HSA-9010553;Reactome: R-HSA-8939236;Reactome: R-HSA-211733;Reactome: R-HSA-382556;Reactome: R-HSA-68949;Reactome: R-HSA-180585;Reactome: R-HSA-450408;Reactome: R-HSA-4641258;Reactome: R-HSA-2467813;Reactome: R-HSA-9604323;Reactome: R-HSA-8948751;Reactome: R-HSA-68827;Reactome: R-HSA-5362768;Reactome: R-HSA-69601;Reactome: R-HSA-69017;Reactome: R-HSA-1234176;Reactome: R-HSA-5676590;Reactome: R-HSA-174113;Reactome: R-HSA-4641257;Reactome: R-HSA-350562;Reactome: R-HSA-5678895;Reactome: R-HSA-69481;Reactome: R-HSA-8951664;Reactome: R-HSA-2871837;Reactome: R-HSA-174184;Reactome: R-HSA-5607764;Reactome: R-HSA-1169091;Reactome: R-HSA-174154;Reactome: R-HSA-187577;Reactome: R-HSA-174084;Reactome: R-HSA-1236974;Reactome: R-HSA-8854050;Reactome: R-HSA-5610783	"MAPK6/MAPK4 signaling";"UCH proteinases";"TNFR2 non-canonical NF-kB pathway";"Asymmetric localization of PCP proteins";"Ub-specific processing proteases";"GLI3 is processed to GLI3R by the proteasome";"Degradation of beta-catenin by the destruction complex";"Regulation of RUNX2 expression and activity";"Ubiquitin-dependent degradation of Cyclin D";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Dectin-1 mediated noncanonical NF-kB signaling";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Degradation of GLI1 by the proteasome";"Cross-presentation of soluble exogenous antigens (endosomes)";"Autodegradation of the E3 ubiquitin ligase COP1";"Vpu mediated degradation of CD4";"Hedgehog 'on' state";"Interleukin-1 signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Downstream TCR signaling";"Regulation of RAS by GAPs";"Hedgehog ligand biogenesis";"Regulation of RUNX3 expression and activity";"Regulation of expression of SLITs and ROBOs";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"ABC-family proteins mediated transport";"Orc1 removal from chromatin";"Vif-mediated degradation of APOBEC3G";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Degradation of DVL";"Separation of Sister Chromatids";"Negative regulation of NOTCH4 signaling";"Regulation of PTEN stability and activity";"CDT1 association with the CDC6:ORC:origin complex";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"CDK-mediated phosphorylation and removal of Cdc6";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"NIK-->noncanonical NF-kB signaling";"SCF-beta-TrCP mediated degradation of Emi1";"Degradation of AXIN";"Regulation of ornithine decarboxylase (ODC)";"Defective CFTR causes cystic fibrosis";"G2/M Checkpoints";"Neddylation";"FCERI mediated NF-kB activation";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"CLEC7A (Dectin-1) signaling";"Activation of NF-kappaB in B cells";"APC/C:Cdc20 mediated degradation of Securin";"SCF(Skp2)-mediated degradation of p27/p21";"Autodegradation of Cdh1 by Cdh1:APC/C";"ER-Phagosome pathway";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Degradation of GLI2 by the proteasome"
Medex_00054994-RA	2	Reactome: R-HSA-1660662;Reactome: R-HSA-390471	"Glycosphingolipid metabolism";"Association of TriC/CCT with target proteins during biosynthesis"
Medex_00092786-RA	2	Reactome: R-HSA-5576892;Reactome: R-HSA-445095	"Phase 0 - rapid depolarisation";"Interaction between L1 and Ankyrins"
Medex_00071159-RA	1	Reactome: R-HSA-216083	"Integrin cell surface interactions"
Medex_00078026-RA	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
Medex_00083427-RA	2	Reactome: R-HSA-1660662;Reactome: R-HSA-390471	"Glycosphingolipid metabolism";"Association of TriC/CCT with target proteins during biosynthesis"
Medex_00022969-RA	4	Reactome: R-HSA-3000178;Reactome: R-HSA-2129379;Reactome: R-HSA-3000170;Reactome: R-HSA-216083	"ECM proteoglycans";"Molecules associated with elastic fibres";"Syndecan interactions";"Integrin cell surface interactions"
Medex_00093049-RA	6	KEGG: 00604+3.2.1.23;KEGG: 00600+3.2.1.23;KEGG: 00511+3.2.1.23;MetaCyc: PWY-6807;KEGG: 00052+3.2.1.23;KEGG: 00531+3.2.1.23	"Glycosphingolipid biosynthesis - ganglio series";"Sphingolipid metabolism";"Other glycan degradation";"Xyloglucan degradation II (exoglucanase)";"Galactose metabolism";"Glycosaminoglycan degradation"
Medex_00054932-RA	1	Reactome: R-HSA-211945	"Phase I - Functionalization of compounds"
Medex_00087649-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00046264-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00051354-RA	3	MetaCyc: PWY-6348;KEGG: 00740+3.1.3.2;KEGG: 00730+3.1.3.2	"Phosphate acquisition";"Riboflavin metabolism";"Thiamine metabolism"
Medex_00047512-RA	1	Reactome: R-HSA-1855231	"Synthesis of IPs in the ER lumen"
Medex_00038808-RA	3	Reactome: R-HSA-8951664;Reactome: R-HSA-381038;Reactome: R-HSA-983168	"Neddylation";"XBP1(S) activates chaperone genes";"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00058673-RA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
Medex_00078962-RA	2	Reactome: R-HSA-8869496;Reactome: R-HSA-1268020	"TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation";"Mitochondrial protein import"
Medex_00006328-RA	2	KEGG: 00510+2.4.1.142;KEGG: 00513+2.4.1.142	"N-Glycan biosynthesis";"Various types of N-glycan biosynthesis"
Medex_00024703-RA	13	Reactome: R-HSA-156902;Reactome: R-HSA-9633012;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-1799339;Reactome: R-HSA-192823;Reactome: R-HSA-975957;Reactome: R-HSA-6791226;Reactome: R-HSA-2408557;Reactome: R-HSA-72764;Reactome: R-HSA-72689;Reactome: R-HSA-72706;Reactome: R-HSA-975956	"Peptide chain elongation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"SRP-dependent cotranslational protein targeting to membrane";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"Selenocysteine synthesis";"Eukaryotic Translation Termination";"Formation of a pool of free 40S subunits";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"
Medex_00055573-RA	4	Reactome: R-HSA-532668;Reactome: R-HSA-3108214;Reactome: R-HSA-5696395;Reactome: R-HSA-5696394	"N-glycan trimming in the ER and Calnexin/Calreticulin cycle";"SUMOylation of DNA damage response and repair proteins";"Formation of Incision Complex in GG-NER";"DNA Damage Recognition in GG-NER"
Medex_00063333-RA	4	KEGG: 00330+1.2.1.41;MetaCyc: PWY-6922;Reactome: R-HSA-8964539;KEGG: 00332+1.2.1.41	"Arginine and proline metabolism";"L-Ndelta-acetylornithine biosynthesis";"Glutamate and glutamine metabolism";"Carbapenem biosynthesis"
Medex_00017052-RA	6	KEGG: 00073+1.2.1.84;MetaCyc: PWY-7782;MetaCyc: PWY-7656;MetaCyc: PWY-6733;Reactome: R-HSA-9640463;MetaCyc: PWY-5884	"Cutin, suberine and wax biosynthesis";"Plasmalogen biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Sporopollenin precursors biosynthesis";"Wax biosynthesis";"Wax esters biosynthesis I"
Medex_00041037-RA	1	Reactome: R-HSA-432047	"Passive transport by Aquaporins"
Medex_00059094-RA	9	Reactome: R-HSA-1855204;Reactome: R-HSA-416476;MetaCyc: PWY-6367;Reactome: R-HSA-112043;KEGG: 04070+3.1.4.11;KEGG: 00562+3.1.4.11;MetaCyc: PWY-7039;MetaCyc: PWY-6351;MetaCyc: PWY-8052	"Synthesis of IP3 and IP4 in the cytosol";"G alpha (q) signalling events";"D-myo-inositol-5-phosphate metabolism";"PLC beta mediated events";"Phosphatidylinositol signaling system";"Inositol phosphate metabolism";"Phosphatidate metabolism, as a signaling molecule";"D-myo-inositol (1,4,5)-trisphosphate biosynthesis";"2-arachidonoylglycerol biosynthesis"
Medex_00002828-RA	1	Reactome: R-HSA-71403	"Citric acid cycle (TCA cycle)"
Medex_00052654-RA	32	Reactome: R-HSA-72165;Reactome: R-HSA-76042;Reactome: R-HSA-167162;Reactome: R-HSA-167243;Reactome: R-HSA-167287;Reactome: R-HSA-73776;Reactome: R-HSA-167152;Reactome: R-HSA-674695;Reactome: R-HSA-168325;Reactome: R-HSA-77075;Reactome: R-HSA-72203;Reactome: R-HSA-72086;Reactome: R-HSA-167238;Reactome: R-HSA-6796648;Reactome: R-HSA-6803529;Reactome: R-HSA-167158;Reactome: R-HSA-167200;Reactome: R-HSA-167160;Reactome: R-HSA-167246;Reactome: R-HSA-75955;Reactome: R-HSA-9018519;Reactome: R-HSA-167242;Reactome: R-HSA-167172;Reactome: R-HSA-167290;Reactome: R-HSA-72163;Reactome: R-HSA-8851708;Reactome: R-HSA-73779;Reactome: R-HSA-112382;Reactome: R-HSA-113418;Reactome: R-HSA-6807505;Reactome: R-HSA-167161;Reactome: R-HSA-75953	"mRNA Splicing - Minor Pathway";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II HIV Promoter Escape";"Tat-mediated HIV elongation arrest and recovery";"HIV elongation arrest and recovery";"RNA Polymerase II Promoter Escape";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Polymerase II Pre-transcription Events";"Viral Messenger RNA Synthesis";"RNA Pol II CTD phosphorylation and interaction with CE";"Processing of Capped Intron-Containing Pre-mRNA";"mRNA Capping";"Pausing and recovery of Tat-mediated HIV elongation";"TP53 Regulates Transcription of DNA Repair Genes";"FGFR2 alternative splicing";"Formation of the HIV-1 Early Elongation Complex";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Tat-mediated elongation of the HIV-1 transcript";"RNA Polymerase II Transcription Elongation";"Estrogen-dependent gene expression";"Abortive elongation of HIV-1 transcript in the absence of Tat";"Transcription of the HIV genome";"Pausing and recovery of HIV elongation";"mRNA Splicing - Major Pathway";"Signaling by FGFR2 IIIa TM";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Formation of RNA Pol II elongation complex";"Formation of the Early Elongation Complex";"RNA polymerase II transcribes snRNA genes";"HIV Transcription Initiation";"RNA Polymerase II Transcription Initiation"
Medex_00046900-RA	1	Reactome: R-HSA-156584	"Cytosolic sulfonation of small molecules"
Medex_00099171-RA	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
Medex_00032274-RA	5	MetaCyc: PWY-5269;KEGG: 00564+2.7.8.5;Reactome: R-HSA-1483148;MetaCyc: PWY-5668;MetaCyc: PWY-7817	"Cardiolipin biosynthesis II";"Glycerophospholipid metabolism";"Synthesis of PG";"Cardiolipin biosynthesis I";"Type I lipoteichoic acid biosynthesis (S. aureus)"
Medex_00003369-RA	6	KEGG: 00930+3.1.1.17;MetaCyc: PWY-7165;KEGG: 00053+3.1.1.17;KEGG: 00030+3.1.1.17;MetaCyc: PWY-5530;MetaCyc: PWY-2221	"Caprolactam degradation";"L-ascorbate biosynthesis VI (engineered pathway)";"Ascorbate and aldarate metabolism";"Pentose phosphate pathway";"Sorbitol biosynthesis II";"Entner-Doudoroff pathway III (semi-phosphorylative)"
Medex_00093412-RA	2	Reactome: R-HSA-1369062;Reactome: R-HSA-9603798	"ABC transporters in lipid homeostasis";"Class I peroxisomal membrane protein import"
Medex_00032103-RA	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5419276;Reactome: R-HSA-5389840	"Mitochondrial translation initiation";"Mitochondrial translation termination";"Mitochondrial translation elongation"
Medex_00028644-RA	1	Reactome: R-HSA-975578	"Reactions specific to the complex N-glycan synthesis pathway"
Medex_00038267-RA	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
Medex_00013126-RA	2	KEGG: 00520+2.4.1.16;MetaCyc: PWY-6981	"Amino sugar and nucleotide sugar metabolism";"Chitin biosynthesis"
Medex_00034851-RA	2	Reactome: R-HSA-111457;Reactome: R-HSA-111469	"Release of apoptotic factors from the mitochondria";"SMAC, XIAP-regulated apoptotic response"
Medex_00037715-RA	2	Reactome: R-HSA-416482;Reactome: R-HSA-456926	"G alpha (12/13) signalling events";"Thrombin signalling through proteinase activated receptors (PARs)"
Medex_00046652-RA	1	Reactome: R-HSA-162791	"Attachment of GPI anchor to uPAR"
Medex_00031213-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Medex_00018698-RA	57	Reactome: R-HSA-2871837;Reactome: R-HSA-8951664;Reactome: R-HSA-174154;Reactome: R-HSA-1169091;Reactome: R-HSA-5607764;Reactome: R-HSA-174184;Reactome: R-HSA-5676590;Reactome: R-HSA-1234176;Reactome: R-HSA-69601;Reactome: R-HSA-69017;Reactome: R-HSA-5362768;Reactome: R-HSA-8948751;Reactome: R-HSA-9604323;Reactome: R-HSA-68827;Reactome: R-HSA-5678895;Reactome: R-HSA-350562;Reactome: R-HSA-69481;Reactome: R-HSA-4641257;Reactome: R-HSA-174113;Reactome: R-HSA-5610783;Reactome: R-HSA-8854050;Reactome: R-HSA-1236974;Reactome: R-HSA-174084;Reactome: R-HSA-187577;Reactome: R-HSA-5610780;Reactome: R-HSA-8852276;Reactome: R-HSA-5607761;Reactome: R-HSA-174178;Reactome: R-HSA-5632684;Reactome: R-HSA-180534;Reactome: R-HSA-349425;Reactome: R-HSA-1236978;Reactome: R-HSA-5689880;Reactome: R-HSA-5610785;Reactome: R-HSA-4608870;Reactome: R-HSA-5689603;Reactome: R-HSA-5687128;Reactome: R-HSA-5668541;Reactome: R-HSA-75815;Reactome: R-HSA-8939902;Reactome: R-HSA-195253;Reactome: R-HSA-8939236;Reactome: R-HSA-211733;Reactome: R-HSA-382556;Reactome: R-HSA-68949;Reactome: R-HSA-9010553;Reactome: R-HSA-2467813;Reactome: R-HSA-4641258;Reactome: R-HSA-450408;Reactome: R-HSA-180585;Reactome: R-HSA-9020702;Reactome: R-HSA-6798695;Reactome: R-HSA-5358346;Reactome: R-HSA-8941858;Reactome: R-HSA-5658442;Reactome: R-HSA-202424;Reactome: R-HSA-983168	"FCERI mediated NF-kB activation";"Neddylation";"APC/C:Cdc20 mediated degradation of Securin";"Activation of NF-kappaB in B cells";"CLEC7A (Dectin-1) signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"NIK-->noncanonical NF-kB signaling";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"CDK-mediated phosphorylation and removal of Cdc6";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Regulation of PTEN stability and activity";"Negative regulation of NOTCH4 signaling";"CDT1 association with the CDC6:ORC:origin complex";"Defective CFTR causes cystic fibrosis";"Regulation of ornithine decarboxylase (ODC)";"G2/M Checkpoints";"Degradation of AXIN";"SCF-beta-TrCP mediated degradation of Emi1";"Degradation of GLI2 by the proteasome";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"ER-Phagosome pathway";"Autodegradation of Cdh1 by Cdh1:APC/C";"SCF(Skp2)-mediated degradation of p27/p21";"Degradation of GLI1 by the proteasome";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Dectin-1 mediated noncanonical NF-kB signaling";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Hedgehog 'on' state";"Vpu mediated degradation of CD4";"Autodegradation of the E3 ubiquitin ligase COP1";"Cross-presentation of soluble exogenous antigens (endosomes)";"Ub-specific processing proteases";"GLI3 is processed to GLI3R by the proteasome";"Asymmetric localization of PCP proteins";"UCH proteinases";"MAPK6/MAPK4 signaling";"TNFR2 non-canonical NF-kB pathway";"Ubiquitin-dependent degradation of Cyclin D";"Regulation of RUNX2 expression and activity";"Degradation of beta-catenin by the destruction complex";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"ABC-family proteins mediated transport";"Orc1 removal from chromatin";"Regulation of expression of SLITs and ROBOs";"Separation of Sister Chromatids";"Degradation of DVL";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Vif-mediated degradation of APOBEC3G";"Interleukin-1 signaling";"Neutrophil degranulation";"Hedgehog ligand biogenesis";"Regulation of RUNX3 expression and activity";"Regulation of RAS by GAPs";"Downstream TCR signaling";"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00022347-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00056770-RA	1	Reactome: R-HSA-5662702	"Melanin biosynthesis"
Medex_00039782-RA	27	Reactome: R-HSA-159231;Reactome: R-HSA-159227;Reactome: R-HSA-180746;Reactome: R-HSA-168333;Reactome: R-HSA-1169408;Reactome: R-HSA-165054;Reactome: R-HSA-168276;Reactome: R-HSA-5578749;Reactome: R-HSA-159230;Reactome: R-HSA-4615885;Reactome: R-HSA-3371453;Reactome: R-HSA-4085377;Reactome: R-HSA-4570464;Reactome: R-HSA-170822;Reactome: R-HSA-180910;Reactome: R-HSA-168271;Reactome: R-HSA-3301854;Reactome: R-HSA-3232142;Reactome: R-HSA-6784531;Reactome: R-HSA-3108214;Reactome: R-HSA-191859;Reactome: R-HSA-159236;Reactome: R-HSA-168325;Reactome: R-HSA-9610379;Reactome: R-HSA-5619107;Reactome: R-HSA-4551638;Reactome: R-HSA-9609690	"Transport of Mature mRNA Derived from an Intronless Transcript";"Transport of the SLBP independent Mature mRNA";"Nuclear import of Rev protein";"NEP/NS2 Interacts with the Cellular Export Machinery";"ISG15 antiviral mechanism";"Rev-mediated nuclear export of HIV RNA";"NS1 Mediated Effects on Host Pathways";"Transcriptional regulation by small RNAs";"Transport of the SLBP Dependant Mature mRNA";"SUMOylation of DNA replication proteins";"Regulation of HSF1-mediated heat shock response";"SUMOylation of SUMOylation proteins";"SUMOylation of RNA binding proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Vpr-mediated nuclear import of PICs";"Transport of Ribonucleoproteins into the Host Nucleus";"Nuclear Pore Complex (NPC) Disassembly";"SUMOylation of ubiquitinylation proteins";"tRNA processing in the nucleus";"SUMOylation of DNA damage response and repair proteins";"snRNP Assembly";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Viral Messenger RNA Synthesis";"HCMV Late Events";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"SUMOylation of chromatin organization proteins";"HCMV Early Events"
Medex_00032335-RA	1	KEGG: 00270+2.1.1.37	"Cysteine and methionine metabolism"
Medex_00047899-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00001473-RA	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5419276;Reactome: R-HSA-5389840	"Mitochondrial translation initiation";"Mitochondrial translation termination";"Mitochondrial translation elongation"
Medex_00029447-RA	1	Reactome: R-HSA-373080	"Class B/2 (Secretin family receptors)"
Medex_00034155-RA	44	Reactome: R-HSA-450341;Reactome: R-HSA-2559585;KEGG: 04150+2.7.11.24;Reactome: R-HSA-6802955;Reactome: R-HSA-879415;Reactome: R-HSA-74749;Reactome: R-HSA-982772;Reactome: R-HSA-444257;Reactome: R-HSA-162658;Reactome: R-HSA-6811558;Reactome: R-HSA-2871796;Reactome: R-HSA-198753;Reactome: R-HSA-9634638;Reactome: R-HSA-881907;Reactome: R-HSA-6802948;Reactome: R-HSA-8940973;Reactome: R-HSA-112409;Reactome: R-HSA-5674499;Reactome: R-HSA-5673001;Reactome: R-HSA-375165;Reactome: R-HSA-5654727;Reactome: R-HSA-6802946;Reactome: R-HSA-9649948;Reactome: R-HSA-9635465;Reactome: R-HSA-8939211;Reactome: R-HSA-5654733;Reactome: R-HSA-456926;Reactome: R-HSA-6802952;Reactome: R-HSA-5668599;Reactome: R-HSA-1295596;Reactome: R-HSA-5654732;Reactome: R-HSA-8943724;Reactome: R-HSA-202670;Reactome: R-HSA-5663213;Reactome: R-HSA-5654726;Reactome: R-HSA-9627069;Reactome: R-HSA-5674135;Reactome: R-HSA-3371453;Reactome: R-HSA-445144;Reactome: R-HSA-2559582;Reactome: R-HSA-2029482;Reactome: R-HSA-5675221;Reactome: R-HSA-2559580;Reactome: R-HSA-170968	"Activation of the AP-1 family of transcription factors";"Oncogene Induced Senescence";"mTOR signaling pathway";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"Advanced glycosylation endproduct receptor signaling";"Signal attenuation";"Growth hormone receptor signaling";"RSK activation";"Golgi Cisternae Pericentriolar Stack Reorganization";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"FCERI mediated MAPK activation";"ERK/MAPK targets";"Estrogen-dependent nuclear events downstream of ESR-membrane signaling";"Gastrin-CREB signalling pathway via PKC and MAPK";"Signaling by high-kinase activity BRAF mutants";"RUNX2 regulates osteoblast differentiation";"RAF-independent MAPK1/3 activation";"Negative feedback regulation of MAPK pathway";"RAF/MAP kinase cascade";"NCAM signaling for neurite out-growth";"Negative regulation of FGFR2 signaling";"Signaling by moderate kinase activity BRAF mutants";"Signaling downstream of RAS mutants";"Suppression of apoptosis";"ESR-mediated signaling";"Negative regulation of FGFR4 signaling";"Thrombin signalling through proteinase activated receptors (PARs)";"Signaling by BRAF and RAF fusions";"RHO GTPases Activate NADPH Oxidases";"Spry regulation of FGF signaling";"Negative regulation of FGFR3 signaling";"Regulation of PTEN gene transcription";"ERKs are inactivated";"RHO GTPases Activate WASPs and WAVEs";"Negative regulation of FGFR1 signaling";"Regulation of the apoptosome activity";"MAP2K and MAPK activation";"Regulation of HSF1-mediated heat shock response";"Signal transduction by L1";"Senescence-Associated Secretory Phenotype (SASP)";"Regulation of actin dynamics for phagocytic cup formation";"Negative regulation of MAPK pathway";"Oxidative Stress Induced Senescence";"Frs2-mediated activation"
Medex_00011244-RA	5	KEGG: 00730+2.2.1.7;KEGG: 00900+2.2.1.7;MetaCyc: PWY-7560;MetaCyc: PWY-6891;MetaCyc: PWY-6892	"Thiamine metabolism";"Terpenoid backbone biosynthesis";"Methylerythritol phosphate pathway II";"Thiazole biosynthesis II (aerobic bacteria)";"Thiazole biosynthesis I (facultative anaerobic bacteria)"
Medex_00088669-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Medex_00003505-RA	11	Reactome: R-HSA-446205;KEGG: 00051+5.3.1.8;MetaCyc: PWY-6992;MetaCyc: PWY-5659;KEGG: 00520+5.3.1.8;Reactome: R-HSA-4043916;MetaCyc: PWY-882;MetaCyc: PWY-7586;MetaCyc: PWY-7456;MetaCyc: PWY-3881;MetaCyc: PWY-3861	"Synthesis of GDP-mannose";"Fructose and mannose metabolism";"1,5-anhydrofructose degradation";"GDP-mannose biosynthesis";"Amino sugar and nucleotide sugar metabolism";"Defective MPI causes MPI-CDG (CDG-1b)";"L-ascorbate biosynthesis I (L-galactose pathway)";"Beta-1,4-d-mannosyl-n-acetyl-d-glucosamine degradation";"Beta-(1,4)-mannan degradation";"Mannitol biosynthesis";"Mannitol degradation II"
Medex_00003188-RA	2	KEGG: 00511+3.2.1.24;Reactome: R-HSA-8853383	"Other glycan degradation";"Lysosomal oligosaccharide catabolism"
Medex_00009404-RA	3	Reactome: R-HSA-1660662;MetaCyc: PWY-7277;KEGG: 00600+3.1.4.12	"Glycosphingolipid metabolism";"Sphingolipid biosynthesis (mammals)";"Sphingolipid metabolism"
Medex_00012351-RA	1	Reactome: R-HSA-110362	"POLB-Dependent Long Patch Base Excision Repair"
Medex_00041916-RA	4	Reactome: R-HSA-6807047;MetaCyc: PWY-8026;KEGG: 00100+1.3.1.72;Reactome: R-HSA-6807062	"Cholesterol biosynthesis via desmosterol";"Sterol biosynthesis (methylotrophs)";"Steroid biosynthesis";"Cholesterol biosynthesis via lathosterol"
Medex_00002585-RA	1	Reactome: R-HSA-5662702	"Melanin biosynthesis"
Medex_00065059-RA	5	Reactome: R-HSA-2132295;Reactome: R-HSA-5620924;Reactome: R-HSA-6811434;Reactome: R-HSA-1445148;Reactome: R-HSA-983189	"MHC class II antigen presentation";"Intraflagellar transport";"COPI-dependent Golgi-to-ER retrograde traffic";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Kinesins"
Medex_00101826-RA	2	Reactome: R-HSA-5689880;Reactome: R-HSA-110320	"Ub-specific processing proteases";"Translesion Synthesis by POLH"
Medex_00044661-RA	1	Reactome: R-HSA-163841	"Gamma carboxylation, hypusine formation and arylsulfatase activation"
Medex_00051343-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Medex_00087398-RA	1	Reactome: R-HSA-5689603	"UCH proteinases"
Medex_00053482-RA	1	Reactome: R-HSA-6798163	"Choline catabolism"
Medex_00060704-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Medex_00000071-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Medex_00009886-RA	19	Reactome: R-HSA-8964038;Reactome: R-HSA-8964046;Reactome: R-HSA-432142;Reactome: R-HSA-8866423;Reactome: R-HSA-3000484;Reactome: R-HSA-5686938;Reactome: R-HSA-8964026;Reactome: R-HSA-8856825;Reactome: R-HSA-3000480;Reactome: R-HSA-8963901;Reactome: R-HSA-8856828;Reactome: R-HSA-8964041;Reactome: R-HSA-8963888;Reactome: R-HSA-975634;Reactome: R-HSA-3000471;Reactome: R-HSA-381426;Reactome: R-HSA-8957275;Reactome: R-HSA-3000497;Reactome: R-HSA-202733	"LDL clearance";"VLDL clearance";"Platelet sensitization by LDL";"VLDL assembly";"Scavenging by Class F Receptors";"Regulation of TLR by endogenous ligand";"Chylomicron clearance";"Cargo recognition for clathrin-mediated endocytosis";"Scavenging by Class A Receptors";"Chylomicron remodeling";"Clathrin-mediated endocytosis";"LDL remodeling";"Chylomicron assembly";"Retinoid metabolism and transport";"Scavenging by Class B Receptors";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"Post-translational protein phosphorylation";"Scavenging by Class H Receptors";"Cell surface interactions at the vascular wall"
Medex_00044142-RA	6	Reactome: R-HSA-1660499;KEGG: 00562+3.1.3.66;MetaCyc: PWY-6368;Reactome: R-HSA-1660516;KEGG: 04070+3.1.3.66;Reactome: R-HSA-1855183	"Synthesis of PIPs at the plasma membrane";"Inositol phosphate metabolism";"3-phosphoinositide degradation";"Synthesis of PIPs at the early endosome membrane";"Phosphatidylinositol signaling system";"Synthesis of IP2, IP, and Ins in the cytosol"
Medex_00102471-RA	1	Reactome: R-HSA-5658442	"Regulation of RAS by GAPs"
Medex_00048164-RA	4	Reactome: R-HSA-72086;MetaCyc: PWY-7375;Reactome: R-HSA-77075;Reactome: R-HSA-167160	"mRNA Capping";"Mrna capping I";"RNA Pol II CTD phosphorylation and interaction with CE";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection"
Medex_00023347-RA	8	Reactome: R-HSA-380284;Reactome: R-HSA-380259;Reactome: R-HSA-380270;Reactome: R-HSA-5620912;Reactome: R-HSA-2565942;Reactome: R-HSA-6798695;Reactome: R-HSA-380320;Reactome: R-HSA-8854518	"Loss of proteins required for interphase microtubule organization from the centrosome";"Loss of Nlp from mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes";"Anchoring of the basal body to the plasma membrane";"Regulation of PLK1 Activity at G2/M Transition";"Neutrophil degranulation";"Recruitment of NuMA to mitotic centrosomes";"AURKA Activation by TPX2"
Medex_00073424-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Medex_00051146-RA	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
Medex_00011600-RA	4	KEGG: 00510+2.4.1.259+2.4.1.261;Reactome: R-HSA-446193;KEGG: 00513+2.4.1.261;Reactome: R-HSA-4720454	"N-Glycan biosynthesis";"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"Various types of N-glycan biosynthesis";"Defective ALG9 causes ALG9-CDG (CDG-1l)"
Medex_00060418-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00059007-RA	1	Reactome: R-HSA-3214842	"HDMs demethylate histones"
Medex_00036538-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Medex_00023714-RA	3	Reactome: R-HSA-4724325;Reactome: R-HSA-446193;KEGG: 00510+2.4.1.265	"Defective ALG8 causes ALG8-CDG (CDG-1h)";"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"N-Glycan biosynthesis"
Medex_00035829-RA	5	Reactome: R-HSA-983712;Reactome: R-HSA-77387;Reactome: R-HSA-9639288;Reactome: R-HSA-1222556;Reactome: R-HSA-917977	"Ion channel transport";"Insulin receptor recycling";"Amino acids regulate mTORC1";"ROS and RNS production in phagocytes";"Transferrin endocytosis and recycling"
Medex_00051262-RA	1	Reactome: R-HSA-912446	"Meiotic recombination"
Medex_00079995-RA	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840	"Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation"
Medex_00064871-RA	17	Reactome: R-HSA-192823;Reactome: R-HSA-72649;Reactome: R-HSA-156902;Reactome: R-HSA-72695;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-72689;Reactome: R-HSA-6790901;Reactome: R-HSA-2408557;Reactome: R-HSA-975957;Reactome: R-HSA-1799339;Reactome: R-HSA-9633012;Reactome: R-HSA-72706;Reactome: R-HSA-975956;Reactome: R-HSA-72764;Reactome: R-HSA-72702;Reactome: R-HSA-6791226	"Viral mRNA Translation";"Translation initiation complex formation";"Peptide chain elongation";"Formation of the ternary complex, and subsequently, the 43S complex";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Formation of a pool of free 40S subunits";"rRNA modification in the nucleus and cytosol";"Selenocysteine synthesis";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Ribosomal scanning and start codon recognition";"Major pathway of rRNA processing in the nucleolus and cytosol"
Medex_00048071-RA	1	MetaCyc: PWY-7942	"5-oxo-L-proline metabolism"
Medex_00073100-RA	1	Reactome: R-HSA-6798163	"Choline catabolism"
Medex_00028500-RA	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
Medex_00079050-RA	2	Reactome: R-HSA-1660662;Reactome: R-HSA-1663150	"Glycosphingolipid metabolism";"The activation of arylsulfatases"
Medex_00062239-RA	1	Reactome: R-HSA-1971475	"A tetrasaccharide linker sequence is required for GAG synthesis"
Medex_00021189-RA	2	Reactome: R-HSA-1989781;Reactome: R-HSA-381340	"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation"
Medex_00056312-RA	1	Reactome: R-HSA-211981	"Xenobiotics"
Medex_00034852-RA	2	Reactome: R-HSA-111457;Reactome: R-HSA-111469	"Release of apoptotic factors from the mitochondria";"SMAC, XIAP-regulated apoptotic response"
Medex_00100166-RA	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
Medex_00022901-RA	1	KEGG: 00480+3.4.11.1	"Glutathione metabolism"
Medex_00084493-RA	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
Medex_00064764-RA	1	Reactome: R-HSA-176974	"Unwinding of DNA"
Medex_00046217-RA	1	Reactome: R-HSA-70221	"Glycogen breakdown (glycogenolysis)"
Medex_00099345-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Medex_00031212-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Medex_00076480-RA	6	Reactome: R-HSA-9640463;MetaCyc: PWY-5884;MetaCyc: PWY-7782;MetaCyc: PWY-7656;MetaCyc: PWY-6733;KEGG: 00073+1.2.1.84	"Wax biosynthesis";"Wax esters biosynthesis I";"Plasmalogen biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Sporopollenin precursors biosynthesis";"Cutin, suberine and wax biosynthesis"
Medex_00063248-RA	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
Medex_00050955-RA	5	Reactome: R-HSA-5696400;Reactome: R-HSA-6782135;Reactome: R-HSA-5696395;Reactome: R-HSA-6783310;Reactome: R-HSA-5685938	"Dual Incision in GG-NER";"Dual incision in TC-NER";"Formation of Incision Complex in GG-NER";"Fanconi Anemia Pathway";"HDR through Single Strand Annealing (SSA)"
Medex_00077273-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Medex_00038631-RA	3	Reactome: R-HSA-196757;KEGG: 00790+6.3.2.17;MetaCyc: PWY-2161	"Metabolism of folate and pterines";"Folate biosynthesis";"Folate polyglutamylation"
Medex_00023031-RA	3	Reactome: R-HSA-3000157;Reactome: R-HSA-8874081;Reactome: R-HSA-3000171	"Laminin interactions";"MET activates PTK2 signaling";"Non-integrin membrane-ECM interactions"
Medex_00013540-RA	8	MetaCyc: PWY-5154;MetaCyc: PWY-5;KEGG: 00250+4.3.2.1;KEGG: 00220+4.3.2.1;MetaCyc: PWY-4983;MetaCyc: PWY-7400;Reactome: R-HSA-70635;MetaCyc: PWY-4984	"L-arginine biosynthesis III (via N-acetyl-L-citrulline)";"Canavanine biosynthesis";"Alanine, aspartate and glutamate metabolism";"Arginine biosynthesis";"Nitric oxide biosynthesis II (mammals)";"L-arginine biosynthesis IV (archaebacteria)";"Urea cycle";"Urea cycle"
Medex_00047293-RA	3	Reactome: R-HSA-6798695;KEGG: 00511+3.2.1.51;MetaCyc: PWY-6807	"Neutrophil degranulation";"Other glycan degradation";"Xyloglucan degradation II (exoglucanase)"
Medex_00011835-RA	4	Reactome: R-HSA-72163;Reactome: R-HSA-73856;Reactome: R-HSA-72187;Reactome: R-HSA-159236	"mRNA Splicing - Major Pathway";"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing";"Transport of Mature mRNA derived from an Intron-Containing Transcript"
Medex_00006974-RA	2	Reactome: R-HSA-8949215;Reactome: R-HSA-8949664	"Mitochondrial calcium ion transport";"Processing of SMDT1"
Medex_00005645-RA	1	Reactome: R-HSA-176974	"Unwinding of DNA"
Medex_00023805-RA	8	KEGG: 00564+3.1.3.27;MetaCyc: PWY-5269;KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16;Reactome: R-HSA-1483148;MetaCyc: PWY-5668;MetaCyc: PWY-7817;KEGG: 04660+3.1.3.16	"Glycerophospholipid metabolism";"Cardiolipin biosynthesis II";"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Synthesis of PG";"Cardiolipin biosynthesis I";"Type I lipoteichoic acid biosynthesis (S. aureus)";"T cell receptor signaling pathway"
Medex_00059392-RA	27	Reactome: R-HSA-168325;Reactome: R-HSA-191859;Reactome: R-HSA-159236;Reactome: R-HSA-3108214;Reactome: R-HSA-6784531;Reactome: R-HSA-9609690;Reactome: R-HSA-4551638;Reactome: R-HSA-9610379;Reactome: R-HSA-5619107;Reactome: R-HSA-170822;Reactome: R-HSA-4570464;Reactome: R-HSA-4085377;Reactome: R-HSA-3232142;Reactome: R-HSA-3301854;Reactome: R-HSA-180910;Reactome: R-HSA-168271;Reactome: R-HSA-168276;Reactome: R-HSA-5578749;Reactome: R-HSA-3371453;Reactome: R-HSA-4615885;Reactome: R-HSA-159230;Reactome: R-HSA-180746;Reactome: R-HSA-159227;Reactome: R-HSA-159231;Reactome: R-HSA-165054;Reactome: R-HSA-1169408;Reactome: R-HSA-168333	"Viral Messenger RNA Synthesis";"snRNP Assembly";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"SUMOylation of DNA damage response and repair proteins";"tRNA processing in the nucleus";"HCMV Early Events";"SUMOylation of chromatin organization proteins";"HCMV Late Events";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"SUMOylation of RNA binding proteins";"SUMOylation of SUMOylation proteins";"SUMOylation of ubiquitinylation proteins";"Nuclear Pore Complex (NPC) Disassembly";"Vpr-mediated nuclear import of PICs";"Transport of Ribonucleoproteins into the Host Nucleus";"NS1 Mediated Effects on Host Pathways";"Transcriptional regulation by small RNAs";"Regulation of HSF1-mediated heat shock response";"SUMOylation of DNA replication proteins";"Transport of the SLBP Dependant Mature mRNA";"Nuclear import of Rev protein";"Transport of the SLBP independent Mature mRNA";"Transport of Mature mRNA Derived from an Intronless Transcript";"Rev-mediated nuclear export of HIV RNA";"ISG15 antiviral mechanism";"NEP/NS2 Interacts with the Cellular Export Machinery"
Medex_00012286-RA	1	Reactome: R-HSA-435368	"Zinc efflux and compartmentalization by the SLC30 family"
Medex_00000376-RA	2	Reactome: R-HSA-5689603;Reactome: R-HSA-5696394	"UCH proteinases";"DNA Damage Recognition in GG-NER"
Medex_00026230-RA	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
Medex_00003638-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00006714-RA	8	Reactome: R-HSA-6791226;KEGG: 04151+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1	"Major pathway of rRNA processing in the nucleolus and cytosol";"PI3K-Akt signaling pathway";"Human cytomegalovirus infection";"Relaxin signaling pathway";"Human papillomavirus infection";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"Thermogenesis"
Medex_00049393-RA	2	Reactome: R-HSA-1989781;Reactome: R-HSA-381340	"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation"
Medex_00035185-RA	13	Reactome: R-HSA-1474244;Reactome: R-HSA-419037;Reactome: R-HSA-3000157;Reactome: R-HSA-2214320;Reactome: R-HSA-186797;Reactome: R-HSA-3000171;Reactome: R-HSA-3000178;Reactome: R-HSA-216083;Reactome: R-HSA-2243919;Reactome: R-HSA-1442490;Reactome: R-HSA-1650814;Reactome: R-HSA-2022090;Reactome: R-HSA-8948216	"Extracellular matrix organization";"NCAM1 interactions";"Laminin interactions";"Anchoring fibril formation";"Signaling by PDGF";"Non-integrin membrane-ECM interactions";"ECM proteoglycans";"Integrin cell surface interactions";"Crosslinking of collagen fibrils";"Collagen degradation";"Collagen biosynthesis and modifying enzymes";"Assembly of collagen fibrils and other multimeric structures";"Collagen chain trimerization"
Medex_00053156-RA	4	Reactome: R-HSA-6807047;MetaCyc: PWY-8026;KEGG: 00100+1.3.1.72;Reactome: R-HSA-6807062	"Cholesterol biosynthesis via desmosterol";"Sterol biosynthesis (methylotrophs)";"Steroid biosynthesis";"Cholesterol biosynthesis via lathosterol"
Medex_00103231-RA	1	KEGG: 04660+2.7.10.2	"T cell receptor signaling pathway"
Medex_00014164-RA	3	KEGG: 00790+3.1.3.1;MetaCyc: PWY-5491;KEGG: 00730+3.1.3.1	"Folate biosynthesis";"Diethylphosphate degradation";"Thiamine metabolism"
Medex_00098884-RA	1	Reactome: R-HSA-6798163	"Choline catabolism"
Medex_00050271-RA	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
Medex_00000392-RA	3	Reactome: R-HSA-983189;Reactome: R-HSA-6811434;Reactome: R-HSA-390471	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic";"Association of TriC/CCT with target proteins during biosynthesis"
Medex_00088497-RA	1	KEGG: 00230+4.6.1.2	"Purine metabolism"
Medex_00004078-RA	1	KEGG: 00970+6.1.1.3	"Aminoacyl-tRNA biosynthesis"
Medex_00086293-RA	16	Reactome: R-HSA-192823;Reactome: R-HSA-72649;Reactome: R-HSA-156902;Reactome: R-HSA-72695;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-72689;Reactome: R-HSA-2408557;Reactome: R-HSA-975957;Reactome: R-HSA-1799339;Reactome: R-HSA-9633012;Reactome: R-HSA-72706;Reactome: R-HSA-975956;Reactome: R-HSA-72764;Reactome: R-HSA-72702;Reactome: R-HSA-6791226	"Viral mRNA Translation";"Translation initiation complex formation";"Peptide chain elongation";"Formation of the ternary complex, and subsequently, the 43S complex";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Formation of a pool of free 40S subunits";"Selenocysteine synthesis";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Ribosomal scanning and start codon recognition";"Major pathway of rRNA processing in the nucleolus and cytosol"
Medex_00031082-RA	19	MetaCyc: PWY-735;MetaCyc: PWY-7606;MetaCyc: PWY-6837;MetaCyc: PWY-7858;KEGG: 00640+1.3.3.6;MetaCyc: PWY-7340;MetaCyc: PWY-7337;MetaCyc: PWY-7574;KEGG: 00071+1.3.3.6;MetaCyc: PWY-7338;MetaCyc: PWY-7007;MetaCyc: PWY-5136;MetaCyc: PWY-7291;MetaCyc: PWY-6920;MetaCyc: PWY-7288;KEGG: 00410+1.3.3.6;MetaCyc: PWY-7854;MetaCyc: PWY-7726;KEGG: 00592+1.3.3.6	"Jasmonic acid biosynthesis";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Fatty acid beta-oxidation V (unsaturated, odd number, di-isomerase-dependent)";"(5Z)-dodecenoate biosynthesis II";"Propanoate metabolism";"9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast)";"10-cis-heptadecenoyl-CoA degradation (yeast)";"Propanoyl-coa degradation II";"Fatty acid degradation";"10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast)";"Methyl ketone biosynthesis (engineered)";"Fatty acid beta-oxidation II (plant peroxisome)";"Oleate beta-oxidation (isomerase-dependent, yeast)";"6-gingerol analog biosynthesis (engineered)";"Fatty acid beta-oxidation VII (yeast peroxisome)";"beta-Alanine metabolism";"Crotonyl-coa/ethylmalonyl-coa/hydroxybutyryl-coa cycle (engineered)";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"alpha-Linolenic acid metabolism"
Medex_00059049-RA	15	Reactome: R-HSA-70171;MetaCyc: PWY-6886;MetaCyc: PWY-2221;KEGG: 00230+2.7.1.40;MetaCyc: PWY-7003;KEGG: 00620+2.7.1.40;MetaCyc: PWY-6901;MetaCyc: PWY-6142;MetaCyc: PWY-1042;MetaCyc: PWY-5723;MetaCyc: PWY-8004;MetaCyc: PWY-7383;KEGG: 00010+2.7.1.40;MetaCyc: PWY-7218;MetaCyc: PWY-5484	"Glycolysis";"1-butanol autotrophic biosynthesis (engineered)";"Entner-Doudoroff pathway III (semi-phosphorylative)";"Purine metabolism";"Glycerol degradation to butanol";"Pyruvate metabolism";"Superpathway of glucose and xylose degradation";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Glycolysis IV (plant cytosol)";"Rubisco shunt";"Entner-Doudoroff pathway I";"Anaerobic energy metabolism (invertebrates, cytosol)";"Glycolysis / Gluconeogenesis";"Photosynthetic 3-hydroxybutanoate biosynthesis (engineered)";"Glycolysis II (from fructose 6-phosphate)"
Medex_00012945-RA	1	Reactome: R-HSA-2132295	"MHC class II antigen presentation"
Medex_00032326-RA	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
Medex_00084788-RA	1	Reactome: R-HSA-442660	"Na+/Cl- dependent neurotransmitter transporters"
Medex_00036357-RA	1	Reactome: R-HSA-428359	"Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA"
Medex_00098053-RA	2	Reactome: R-HSA-975957;Reactome: R-HSA-9010553	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs"
Medex_00033884-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Medex_00038327-RA	3	Reactome: R-HSA-416482;Reactome: R-HSA-194840;Reactome: R-HSA-193648	"G alpha (12/13) signalling events";"Rho GTPase cycle";"NRAGE signals death through JNK"
Medex_00059078-RA	4	KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16;Reactome: R-HSA-180024;KEGG: 04660+3.1.3.16	"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"DARPP-32 events";"T cell receptor signaling pathway"
Medex_00059863-RA	3	Reactome: R-HSA-5423646;MetaCyc: PWY-7533;Reactome: R-HSA-2142691	"Aflatoxin activation and detoxification";"Gliotoxin biosynthesis";"Synthesis of Leukotrienes (LT) and Eoxins (EX)"
Medex_00047862-RA	16	Reactome: R-HSA-72702;Reactome: R-HSA-6791226;Reactome: R-HSA-72706;Reactome: R-HSA-975956;Reactome: R-HSA-72764;Reactome: R-HSA-1799339;Reactome: R-HSA-9633012;Reactome: R-HSA-975957;Reactome: R-HSA-2408557;Reactome: R-HSA-72689;Reactome: R-HSA-72649;Reactome: R-HSA-156902;Reactome: R-HSA-72695;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-192823	"Ribosomal scanning and start codon recognition";"Major pathway of rRNA processing in the nucleolus and cytosol";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"SRP-dependent cotranslational protein targeting to membrane";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Selenocysteine synthesis";"Formation of a pool of free 40S subunits";"Translation initiation complex formation";"Peptide chain elongation";"Formation of the ternary complex, and subsequently, the 43S complex";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Viral mRNA Translation"
Medex_00078220-RA	4	KEGG: 00480+1.1.1.49;MetaCyc: PWY-8004;MetaCyc: PWY-7268;KEGG: 00030+1.1.1.49	"Glutathione metabolism";"Entner-Doudoroff pathway I";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"Pentose phosphate pathway"
Medex_00006835-RA	2	Reactome: R-HSA-68962;Reactome: R-HSA-176187	"Activation of the pre-replicative complex";"Activation of ATR in response to replication stress"
Medex_00078516-RA	3	Reactome: R-HSA-5620916;Reactome: R-HSA-264876;Reactome: R-HSA-1445148	"VxPx cargo-targeting to cilium";"Insulin processing";"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
Medex_00064260-RA	1	Reactome: R-HSA-191859	"snRNP Assembly"
Medex_00067763-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00088809-RA	2	Reactome: R-HSA-171319;Reactome: R-HSA-6790901	"Telomere Extension By Telomerase";"rRNA modification in the nucleus and cytosol"
Medex_00059034-RA	2	Reactome: R-HSA-2408522;Reactome: R-HSA-379716	"Selenoamino acid metabolism";"Cytosolic tRNA aminoacylation"
Medex_00008405-RA	3	Reactome: R-HSA-193648;Reactome: R-HSA-416482;Reactome: R-HSA-194840	"NRAGE signals death through JNK";"G alpha (12/13) signalling events";"Rho GTPase cycle"
Medex_00038848-RA	2	Reactome: R-HSA-1660662;Reactome: R-HSA-390471	"Glycosphingolipid metabolism";"Association of TriC/CCT with target proteins during biosynthesis"
Medex_00024257-RA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
Medex_00087757-RA	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
Medex_00029030-RA	5	Reactome: R-HSA-75105;Reactome: R-HSA-9029558;Reactome: R-HSA-199220;Reactome: R-HSA-163765;Reactome: R-HSA-2426168	"Fatty acyl-CoA biosynthesis";"NR1H2 & NR1H3 regulate gene expression linked to lipogenesis";"Vitamin B5 (pantothenate) metabolism";"ChREBP activates metabolic gene expression";"Activation of gene expression by SREBF (SREBP)"
Medex_00086388-RA	1	Reactome: R-HSA-6787450	"tRNA modification in the mitochondrion"
Medex_00100674-RA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
Medex_00010340-RA	1	Reactome: R-HSA-202733	"Cell surface interactions at the vascular wall"
Medex_00044135-RA	56	Reactome: R-HSA-5678895;Reactome: R-HSA-69481;Reactome: R-HSA-350562;Reactome: R-HSA-4641257;Reactome: R-HSA-174113;Reactome: R-HSA-5676590;Reactome: R-HSA-1234176;Reactome: R-HSA-5362768;Reactome: R-HSA-69017;Reactome: R-HSA-69601;Reactome: R-HSA-9604323;Reactome: R-HSA-8948751;Reactome: R-HSA-68827;Reactome: R-HSA-174154;Reactome: R-HSA-1169091;Reactome: R-HSA-5607764;Reactome: R-HSA-174184;Reactome: R-HSA-2871837;Reactome: R-HSA-8951664;Reactome: R-HSA-174084;Reactome: R-HSA-187577;Reactome: R-HSA-5610783;Reactome: R-HSA-8854050;Reactome: R-HSA-1236974;Reactome: R-HSA-75815;Reactome: R-HSA-8939902;Reactome: R-HSA-195253;Reactome: R-HSA-5610785;Reactome: R-HSA-5689880;Reactome: R-HSA-4608870;Reactome: R-HSA-5689603;Reactome: R-HSA-5668541;Reactome: R-HSA-5687128;Reactome: R-HSA-5632684;Reactome: R-HSA-180534;Reactome: R-HSA-349425;Reactome: R-HSA-1236978;Reactome: R-HSA-5610780;Reactome: R-HSA-8852276;Reactome: R-HSA-5607761;Reactome: R-HSA-174178;Reactome: R-HSA-5358346;Reactome: R-HSA-8941858;Reactome: R-HSA-5658442;Reactome: R-HSA-202424;Reactome: R-HSA-983168;Reactome: R-HSA-9020702;Reactome: R-HSA-2467813;Reactome: R-HSA-4641258;Reactome: R-HSA-450408;Reactome: R-HSA-180585;Reactome: R-HSA-211733;Reactome: R-HSA-68949;Reactome: R-HSA-382556;Reactome: R-HSA-8939236;Reactome: R-HSA-9010553	"Defective CFTR causes cystic fibrosis";"G2/M Checkpoints";"Regulation of ornithine decarboxylase (ODC)";"Degradation of AXIN";"SCF-beta-TrCP mediated degradation of Emi1";"NIK-->noncanonical NF-kB signaling";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"CDK-mediated phosphorylation and removal of Cdc6";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Negative regulation of NOTCH4 signaling";"Regulation of PTEN stability and activity";"CDT1 association with the CDC6:ORC:origin complex";"APC/C:Cdc20 mediated degradation of Securin";"Activation of NF-kappaB in B cells";"CLEC7A (Dectin-1) signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"FCERI mediated NF-kB activation";"Neddylation";"Autodegradation of Cdh1 by Cdh1:APC/C";"SCF(Skp2)-mediated degradation of p27/p21";"Degradation of GLI2 by the proteasome";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"ER-Phagosome pathway";"Ubiquitin-dependent degradation of Cyclin D";"Regulation of RUNX2 expression and activity";"Degradation of beta-catenin by the destruction complex";"GLI3 is processed to GLI3R by the proteasome";"Ub-specific processing proteases";"Asymmetric localization of PCP proteins";"UCH proteinases";"TNFR2 non-canonical NF-kB pathway";"MAPK6/MAPK4 signaling";"Hedgehog 'on' state";"Vpu mediated degradation of CD4";"Autodegradation of the E3 ubiquitin ligase COP1";"Cross-presentation of soluble exogenous antigens (endosomes)";"Degradation of GLI1 by the proteasome";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Dectin-1 mediated noncanonical NF-kB signaling";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Hedgehog ligand biogenesis";"Regulation of RUNX3 expression and activity";"Regulation of RAS by GAPs";"Downstream TCR signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Interleukin-1 signaling";"Separation of Sister Chromatids";"Degradation of DVL";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Vif-mediated degradation of APOBEC3G";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Orc1 removal from chromatin";"ABC-family proteins mediated transport";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Regulation of expression of SLITs and ROBOs"
Medex_00075722-RA	3	MetaCyc: PWY-8099;KEGG: 00790+4.2.1.96;MetaCyc: PWY-7158	"Tetrahydropteridine recycling";"Folate biosynthesis";"L-phenylalanine degradation V"
Medex_00083456-RA	3	Reactome: R-HSA-156590;Reactome: R-HSA-204174;Reactome: R-HSA-8963684	"Glutathione conjugation";"Regulation of pyruvate dehydrogenase (PDH) complex";"Tyrosine catabolism"
Medex_00039489-RA	9	Reactome: R-HSA-167172;Reactome: R-HSA-167161;Reactome: R-HSA-75953;Reactome: R-HSA-73776;Reactome: R-HSA-674695;Reactome: R-HSA-76042;Reactome: R-HSA-167162;Reactome: R-HSA-73779;Reactome: R-HSA-6804756	"Transcription of the HIV genome";"HIV Transcription Initiation";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Regulation of TP53 Activity through Phosphorylation"
Medex_00079761-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Medex_00002821-RA	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
Medex_00026040-RA	4	Reactome: R-HSA-1660662;MetaCyc: PWY-7119;KEGG: 00600+3.5.1.23;MetaCyc: PWY-6483	"Glycosphingolipid metabolism";"Ceramide and sphingolipid recycling and degradation (yeast)";"Sphingolipid metabolism";"Ceramide degradation (generic)"
Medex_00029732-RA	1	Reactome: R-HSA-3108214	"SUMOylation of DNA damage response and repair proteins"
Medex_00026186-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Medex_00003519-RA	2	Reactome: R-HSA-9634600;KEGG: 00051+2.7.1.105+3.1.3.46	"Regulation of glycolysis by fructose 2,6-bisphosphate metabolism";"Fructose and mannose metabolism"
Medex_00090792-RA	5	KEGG: 00760+2.7.1.23;MetaCyc: PWY-7269;Reactome: R-HSA-196807;MetaCyc: PWY-5083;MetaCyc: PWY-7268	"Nicotinate and nicotinamide metabolism";"NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)";"Nicotinate metabolism";"NAD/NADH phosphorylation and dephosphorylation";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)"
Medex_00019347-RA	27	Reactome: R-HSA-3371453;Reactome: R-HSA-159230;Reactome: R-HSA-4615885;Reactome: R-HSA-5578749;Reactome: R-HSA-168276;Reactome: R-HSA-165054;Reactome: R-HSA-168333;Reactome: R-HSA-1169408;Reactome: R-HSA-159227;Reactome: R-HSA-180746;Reactome: R-HSA-159231;Reactome: R-HSA-4551638;Reactome: R-HSA-9609690;Reactome: R-HSA-9610379;Reactome: R-HSA-5619107;Reactome: R-HSA-191859;Reactome: R-HSA-159236;Reactome: R-HSA-168325;Reactome: R-HSA-6784531;Reactome: R-HSA-3108214;Reactome: R-HSA-3301854;Reactome: R-HSA-3232142;Reactome: R-HSA-168271;Reactome: R-HSA-180910;Reactome: R-HSA-4570464;Reactome: R-HSA-170822;Reactome: R-HSA-4085377	"Regulation of HSF1-mediated heat shock response";"Transport of the SLBP Dependant Mature mRNA";"SUMOylation of DNA replication proteins";"Transcriptional regulation by small RNAs";"NS1 Mediated Effects on Host Pathways";"Rev-mediated nuclear export of HIV RNA";"NEP/NS2 Interacts with the Cellular Export Machinery";"ISG15 antiviral mechanism";"Transport of the SLBP independent Mature mRNA";"Nuclear import of Rev protein";"Transport of Mature mRNA Derived from an Intronless Transcript";"SUMOylation of chromatin organization proteins";"HCMV Early Events";"HCMV Late Events";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"snRNP Assembly";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Viral Messenger RNA Synthesis";"tRNA processing in the nucleus";"SUMOylation of DNA damage response and repair proteins";"Nuclear Pore Complex (NPC) Disassembly";"SUMOylation of ubiquitinylation proteins";"Transport of Ribonucleoproteins into the Host Nucleus";"Vpr-mediated nuclear import of PICs";"SUMOylation of RNA binding proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"SUMOylation of SUMOylation proteins"
Medex_00020202-RA	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
Medex_00070468-RA	7	MetaCyc: PWY-8052;KEGG: 04070+3.1.4.11;MetaCyc: PWY-6367;MetaCyc: PWY-6351;MetaCyc: PWY-7039;KEGG: 00562+3.1.4.11;Reactome: R-HSA-1855204	"2-arachidonoylglycerol biosynthesis";"Phosphatidylinositol signaling system";"D-myo-inositol-5-phosphate metabolism";"D-myo-inositol (1,4,5)-trisphosphate biosynthesis";"Phosphatidate metabolism, as a signaling molecule";"Inositol phosphate metabolism";"Synthesis of IP3 and IP4 in the cytosol"
Medex_00077210-RA	1	Reactome: R-HSA-5628897	"TP53 Regulates Metabolic Genes"
Medex_00098273-RA	1	Reactome: R-HSA-156842	"Eukaryotic Translation Elongation"
Medex_00054782-RA	1	Reactome: R-HSA-162658	"Golgi Cisternae Pericentriolar Stack Reorganization"
Medex_00012693-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Medex_00059403-RA	3	Reactome: R-HSA-72203;Reactome: R-HSA-6803529;Reactome: R-HSA-72163	"Processing of Capped Intron-Containing Pre-mRNA";"FGFR2 alternative splicing";"mRNA Splicing - Major Pathway"
Medex_00025545-RA	2	KEGG: 00270+3.3.1.1;MetaCyc: PWY-5041	"Cysteine and methionine metabolism";"S-adenosyl-L-methionine cycle II"
Medex_00031300-RA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Medex_00010731-RA	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
Medex_00031474-RA	1	Reactome: R-HSA-203927	"MicroRNA (miRNA) biogenesis"
Medex_00021408-RA	5	Reactome: R-HSA-4641257;Reactome: R-HSA-5545619;Reactome: R-HSA-8948751;Reactome: R-HSA-201681;Reactome: R-HSA-5689880	"Degradation of AXIN";"XAV939 inhibits tankyrase, stabilizing AXIN";"Regulation of PTEN stability and activity";"TCF dependent signaling in response to WNT";"Ub-specific processing proteases"
Medex_00090363-RA	8	Reactome: R-HSA-68827;Reactome: R-HSA-176187;Reactome: R-HSA-68689;Reactome: R-HSA-113507;Reactome: R-HSA-68962;Reactome: R-HSA-68949;Reactome: R-HSA-68867;Reactome: R-HSA-68616	"CDT1 association with the CDC6:ORC:origin complex";"Activation of ATR in response to replication stress";"CDC6 association with the ORC:origin complex";"E2F-enabled inhibition of pre-replication complex formation";"Activation of the pre-replicative complex";"Orc1 removal from chromatin";"Assembly of the pre-replicative complex";"Assembly of the ORC complex at the origin of replication"
Medex_00036936-RA	5	Reactome: R-HSA-73762;Reactome: R-HSA-427413;Reactome: R-HSA-5250924;Reactome: R-HSA-73863;Reactome: R-HSA-73772	"RNA Polymerase I Transcription Initiation";"NoRC negatively regulates rRNA expression";"B-WICH complex positively regulates rRNA expression";"RNA Polymerase I Transcription Termination";"RNA Polymerase I Promoter Escape"
Medex_00035680-RA	1	Reactome: R-HSA-6809371	"Formation of the cornified envelope"
Medex_00054230-RA	3	Reactome: R-HSA-1474228;Reactome: R-HSA-1592389;Reactome: R-HSA-1442490	"Degradation of the extracellular matrix";"Activation of Matrix Metalloproteinases";"Collagen degradation"
Medex_00014167-RA	3	KEGG: 00730+3.1.3.1;KEGG: 00790+3.1.3.1;MetaCyc: PWY-5491	"Thiamine metabolism";"Folate biosynthesis";"Diethylphosphate degradation"
Medex_00082089-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00025912-RA	2	Reactome: R-HSA-418457;Reactome: R-HSA-4086398	"cGMP effects";"Ca2+ pathway"
Medex_00020315-RA	6	KEGG: 00073+1.2.1.84;MetaCyc: PWY-7782;MetaCyc: PWY-6733;MetaCyc: PWY-7656;MetaCyc: PWY-5884;Reactome: R-HSA-9640463	"Cutin, suberine and wax biosynthesis";"Plasmalogen biosynthesis";"Sporopollenin precursors biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Wax esters biosynthesis I";"Wax biosynthesis"
Medex_00009968-RA	3	Reactome: R-HSA-2142691;Reactome: R-HSA-5423646;MetaCyc: PWY-7533	"Synthesis of Leukotrienes (LT) and Eoxins (EX)";"Aflatoxin activation and detoxification";"Gliotoxin biosynthesis"
Medex_00033171-RA	1	Reactome: R-HSA-162658	"Golgi Cisternae Pericentriolar Stack Reorganization"
Medex_00000268-RA	40	Reactome: R-HSA-72165;Reactome: R-HSA-167162;Reactome: R-HSA-76042;Reactome: R-HSA-167287;Reactome: R-HSA-167243;Reactome: R-HSA-674695;Reactome: R-HSA-167152;Reactome: R-HSA-73776;Reactome: R-HSA-6782210;Reactome: R-HSA-72203;Reactome: R-HSA-168325;Reactome: R-HSA-77075;Reactome: R-HSA-72086;Reactome: R-HSA-6796648;Reactome: R-HSA-167238;Reactome: R-HSA-6803529;Reactome: R-HSA-6781827;Reactome: R-HSA-167158;Reactome: R-HSA-167200;Reactome: R-HSA-167246;Reactome: R-HSA-167160;Reactome: R-HSA-5578749;Reactome: R-HSA-5617472;Reactome: R-HSA-203927;Reactome: R-HSA-5601884;Reactome: R-HSA-75955;Reactome: R-HSA-9018519;Reactome: R-HSA-6782135;Reactome: R-HSA-167242;Reactome: R-HSA-72163;Reactome: R-HSA-6781823;Reactome: R-HSA-167290;Reactome: R-HSA-167172;Reactome: R-HSA-8851708;Reactome: R-HSA-112382;Reactome: R-HSA-73779;Reactome: R-HSA-113418;Reactome: R-HSA-6807505;Reactome: R-HSA-75953;Reactome: R-HSA-167161	"mRNA Splicing - Minor Pathway";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"HIV elongation arrest and recovery";"Tat-mediated HIV elongation arrest and recovery";"RNA Polymerase II Pre-transcription Events";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Polymerase II Promoter Escape";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Processing of Capped Intron-Containing Pre-mRNA";"Viral Messenger RNA Synthesis";"RNA Pol II CTD phosphorylation and interaction with CE";"mRNA Capping";"TP53 Regulates Transcription of DNA Repair Genes";"Pausing and recovery of Tat-mediated HIV elongation";"FGFR2 alternative splicing";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Formation of the HIV-1 Early Elongation Complex";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Tat-mediated elongation of the HIV-1 transcript";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Transcriptional regulation by small RNAs";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"MicroRNA (miRNA) biogenesis";"PIWI-interacting RNA (piRNA) biogenesis";"RNA Polymerase II Transcription Elongation";"Estrogen-dependent gene expression";"Dual incision in TC-NER";"Abortive elongation of HIV-1 transcript in the absence of Tat";"mRNA Splicing - Major Pathway";"Formation of TC-NER Pre-Incision Complex";"Pausing and recovery of HIV elongation";"Transcription of the HIV genome";"Signaling by FGFR2 IIIa TM";"Formation of RNA Pol II elongation complex";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Formation of the Early Elongation Complex";"RNA polymerase II transcribes snRNA genes";"RNA Polymerase II Transcription Initiation";"HIV Transcription Initiation"
Medex_00070925-RA	1	KEGG: 00900+3.4.24.84	"Terpenoid backbone biosynthesis"
Medex_00009808-RA	2	Reactome: R-HSA-429947;Reactome: R-HSA-6804115	"Deadenylation of mRNA";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"
Medex_00030055-RA	5	MetaCyc: PWY-7177;KEGG: 00240+6.3.4.2;Reactome: R-HSA-499943;MetaCyc: PWY-7176;MetaCyc: PWY-7185	"UTP and CTP dephosphorylation II";"Pyrimidine metabolism";"Interconversion of nucleotide di- and triphosphates";"UTP and CTP de novo biosynthesis";"UTP and CTP dephosphorylation I"
Medex_00068844-RA	6	KEGG: 00052+3.2.1.23;KEGG: 00531+3.2.1.23;KEGG: 00604+3.2.1.23;KEGG: 00600+3.2.1.23;KEGG: 00511+3.2.1.23;MetaCyc: PWY-6807	"Galactose metabolism";"Glycosaminoglycan degradation";"Glycosphingolipid biosynthesis - ganglio series";"Sphingolipid metabolism";"Other glycan degradation";"Xyloglucan degradation II (exoglucanase)"
Medex_00000005-RA	1	Reactome: R-HSA-380320	"Recruitment of NuMA to mitotic centrosomes"
Medex_00078482-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Medex_00025669-RA	4	Reactome: R-HSA-382556;MetaCyc: PWY-6972;Reactome: R-HSA-5679001;Reactome: R-HSA-189483	"ABC-family proteins mediated transport";"Oleandomycin activation/inactivation";"Defective ABCC2 causes Dubin-Johnson syndrome";"Heme degradation"
Medex_00006072-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Medex_00001126-RA	2	KEGG: 00380+1.13.11.11;Reactome: R-HSA-71240	"Tryptophan metabolism";"Tryptophan catabolism"
Medex_00040570-RA	12	KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;Reactome: R-HSA-416482;Reactome: R-HSA-418885;Reactome: R-HSA-416476;Reactome: R-HSA-193648;KEGG: 04151+2.7.11.1;Reactome: R-HSA-194840;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1	"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"mTOR signaling pathway";"Thermogenesis";"G alpha (12/13) signalling events";"DCC mediated attractive signaling";"G alpha (q) signalling events";"NRAGE signals death through JNK";"PI3K-Akt signaling pathway";"Rho GTPase cycle";"Relaxin signaling pathway";"Human cytomegalovirus infection"
Medex_00078608-RA	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
Medex_00046266-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00055039-RA	3	Reactome: R-HSA-381426;Reactome: R-HSA-8957275;Reactome: R-HSA-381038	"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"Post-translational protein phosphorylation";"XBP1(S) activates chaperone genes"
Medex_00011394-RA	7	MetaCyc: PWY-7854;MetaCyc: PWY-7295;MetaCyc: PWY-7294;KEGG: 00620+2.3.3.9;MetaCyc: PWY-7118;MetaCyc: PWY-6969;KEGG: 00630+2.3.3.9	"Crotonyl-coa/ethylmalonyl-coa/hydroxybutyryl-coa cycle (engineered)";"L-arabinose degradation IV";"D-xylose degradation IV";"Pyruvate metabolism";"Chitin degradation to ethanol";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Glyoxylate and dicarboxylate metabolism"
Medex_00011529-RA	5	Reactome: R-HSA-9033500;MetaCyc: PWY-7782;KEGG: 00565+2.5.1.26;Reactome: R-HSA-9033241;Reactome: R-HSA-75896	"TYSND1 cleaves peroxisomal proteins";"Plasmalogen biosynthesis";"Ether lipid metabolism";"Peroxisomal protein import";"Plasmalogen biosynthesis"
Medex_00060210-RA	2	MetaCyc: PWY-6502;Reactome: R-HSA-2393930	"8-oxo-(d)GTP detoxification I";"Phosphate bond hydrolysis by NUDT proteins"
Medex_00062020-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Medex_00045720-RA	3	KEGG: 00740+3.1.3.2;KEGG: 00730+3.1.3.2;MetaCyc: PWY-6348	"Riboflavin metabolism";"Thiamine metabolism";"Phosphate acquisition"
Medex_00061955-RA	1	Reactome: R-HSA-163560	"Triglyceride catabolism"
Medex_00042956-RA	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
Medex_00031083-RA	20	MetaCyc: PWY-735;MetaCyc: PWY-7606;MetaCyc: PWY-6837;MetaCyc: PWY-7858;KEGG: 00640+1.3.3.6;MetaCyc: PWY-7340;Reactome: R-HSA-9033241;MetaCyc: PWY-7574;MetaCyc: PWY-7337;KEGG: 00071+1.3.3.6;MetaCyc: PWY-5136;MetaCyc: PWY-7291;MetaCyc: PWY-7338;MetaCyc: PWY-7007;MetaCyc: PWY-7854;MetaCyc: PWY-7726;KEGG: 00592+1.3.3.6;MetaCyc: PWY-6920;KEGG: 00410+1.3.3.6;MetaCyc: PWY-7288	"Jasmonic acid biosynthesis";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Fatty acid beta-oxidation V (unsaturated, odd number, di-isomerase-dependent)";"(5Z)-dodecenoate biosynthesis II";"Propanoate metabolism";"9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast)";"Peroxisomal protein import";"Propanoyl-coa degradation II";"10-cis-heptadecenoyl-CoA degradation (yeast)";"Fatty acid degradation";"Fatty acid beta-oxidation II (plant peroxisome)";"Oleate beta-oxidation (isomerase-dependent, yeast)";"10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast)";"Methyl ketone biosynthesis (engineered)";"Crotonyl-coa/ethylmalonyl-coa/hydroxybutyryl-coa cycle (engineered)";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"alpha-Linolenic acid metabolism";"6-gingerol analog biosynthesis (engineered)";"beta-Alanine metabolism";"Fatty acid beta-oxidation VII (yeast peroxisome)"
Medex_00056317-RA	1	Reactome: R-HSA-1474228	"Degradation of the extracellular matrix"
Medex_00042706-RA	13	MetaCyc: PWY-7210;KEGG: 00240+1.17.4.1;KEGG: 00983+1.17.4.1;KEGG: 00230+1.17.4.1;MetaCyc: PWY-6545;MetaCyc: PWY-7222;Reactome: R-HSA-499943;MetaCyc: PWY-7198;MetaCyc: PWY-7226;MetaCyc: PWY-7227;MetaCyc: PWY-7184;KEGG: 00480+1.17.4.1;MetaCyc: PWY-7220	"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Pyrimidine metabolism";"Drug metabolism - other enzymes";"Purine metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Guanosine deoxyribonucleotides de novo biosynthesis II";"Interconversion of nucleotide di- and triphosphates";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Guanosine deoxyribonucleotides de novo biosynthesis I";"Adenosine deoxyribonucleotides de novo biosynthesis";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Glutathione metabolism";"Adenosine deoxyribonucleotides de novo biosynthesis II"
Medex_00010147-RA	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
Medex_00048173-RA	1	Reactome: R-HSA-2470946	"Cohesin Loading onto Chromatin"
Medex_00020097-RA	2	MetaCyc: PWY-6749;KEGG: 00520+5.4.2.10	"CMP-legionaminate biosynthesis I";"Amino sugar and nucleotide sugar metabolism"
Medex_00057195-RA	3	KEGG: 00270+5.3.1.23;MetaCyc: PWY-7174;MetaCyc: PWY-4361	"Cysteine and methionine metabolism";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation II";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I"
Medex_00027922-RA	8	Reactome: R-HSA-917977;Reactome: R-HSA-9639288;Reactome: R-HSA-1222556;Reactome: R-HSA-983712;Reactome: R-HSA-77387;MetaCyc: PWY-7980;KEGG: 00190+7.1.2.2;KEGG: 00195+7.1.2.2	"Transferrin endocytosis and recycling";"Amino acids regulate mTORC1";"ROS and RNS production in phagocytes";"Ion channel transport";"Insulin receptor recycling";"ATP biosynthesis";"Oxidative phosphorylation";"Photosynthesis"
Medex_00034621-RA	4	Reactome: R-HSA-351202;KEGG: 00330+2.5.1.16;KEGG: 00480+2.5.1.16;KEGG: 00270+2.5.1.16	"Metabolism of polyamines";"Arginine and proline metabolism";"Glutathione metabolism";"Cysteine and methionine metabolism"
Medex_00006790-RA	1	Reactome: R-HSA-3214858	"RMTs methylate histone arginines"
Medex_00043538-RA	1	Reactome: R-HSA-427413	"NoRC negatively regulates rRNA expression"
Medex_00099365-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Medex_00060337-RA	7	KEGG: 00250+6.3.5.5;KEGG: 00240+6.3.5.5;MetaCyc: PWY-5154;MetaCyc: PWY-7791;MetaCyc: PWY-5686;MetaCyc: PWY-7790;MetaCyc: PWY-7400	"Alanine, aspartate and glutamate metabolism";"Pyrimidine metabolism";"L-arginine biosynthesis III (via N-acetyl-L-citrulline)";"UMP biosynthesis III";"UMP biosynthesis I";"UMP biosynthesis II";"L-arginine biosynthesis IV (archaebacteria)"
Medex_00087193-RA	2	Reactome: R-HSA-1268020;Reactome: R-HSA-1362409	"Mitochondrial protein import";"Mitochondrial iron-sulfur cluster biogenesis"
Medex_00072191-RA	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276	"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination"
Medex_00012423-RA	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
Medex_00037707-RA	1	Reactome: R-HSA-8951664	"Neddylation"
Medex_00064843-RA	1	KEGG: 00970+6.3.5.7	"Aminoacyl-tRNA biosynthesis"
Medex_00066316-RA	8	MetaCyc: PWY-2301;Reactome: R-HSA-1855183;MetaCyc: PWY-4661;MetaCyc: PWY-6664;MetaCyc: PWY-6372;KEGG: 00521+5.5.1.4;MetaCyc: PWY-6580;KEGG: 00562+5.5.1.4	"Myo-inositol biosynthesis";"Synthesis of IP2, IP, and Ins in the cytosol";"1D-myo-inositol hexakisphosphate biosynthesis III (Spirodela polyrrhiza)";"Di-myo-inositol phosphate biosynthesis";"1D-myo-inositol hexakisphosphate biosynthesis IV (Dictyostelium)";"Streptomycin biosynthesis";"Phosphatidylinositol biosynthesis I (bacteria)";"Inositol phosphate metabolism"
Medex_00016272-RA	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
Medex_00020306-RA	3	MetaCyc: PWY-6348;KEGG: 00740+3.1.3.2;KEGG: 00730+3.1.3.2	"Phosphate acquisition";"Riboflavin metabolism";"Thiamine metabolism"
Medex_00053255-RA	3	Reactome: R-HSA-6811438;Reactome: R-HSA-6811440;Reactome: R-HSA-6807878	"Intra-Golgi traffic";"Retrograde transport at the Trans-Golgi-Network";"COPI-mediated anterograde transport"
Medex_00074873-RA	10	Reactome: R-HSA-6804756;Reactome: R-HSA-73779;Reactome: R-HSA-167162;Reactome: R-HSA-76042;Reactome: R-HSA-6807505;Reactome: R-HSA-674695;Reactome: R-HSA-73776;Reactome: R-HSA-75953;Reactome: R-HSA-167161;Reactome: R-HSA-167172	"Regulation of TP53 Activity through Phosphorylation";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA polymerase II transcribes snRNA genes";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Transcription Initiation";"HIV Transcription Initiation";"Transcription of the HIV genome"
Medex_00056279-RA	26	Reactome: R-HSA-5663220;Reactome: R-HSA-389960;Reactome: R-HSA-1445148;Reactome: R-HSA-380320;Reactome: R-HSA-2500257;Reactome: R-HSA-3371497;Reactome: R-HSA-2467813;Reactome: R-HSA-9646399;Reactome: R-HSA-5617833;Reactome: R-HSA-6811434;Reactome: R-HSA-9648025;Reactome: R-HSA-68877;Reactome: R-HSA-389977;Reactome: R-HSA-6807878;Reactome: R-HSA-190840;Reactome: R-HSA-190861;Reactome: R-HSA-9619483;Reactome: R-HSA-437239;Reactome: R-HSA-8955332;Reactome: R-HSA-9609690;Reactome: R-HSA-6811436;Reactome: R-HSA-5626467;Reactome: R-HSA-2132295;Reactome: R-HSA-983189;Reactome: R-HSA-9609736;Reactome: R-HSA-8852276	"RHO GTPases Activate Formins";"Formation of tubulin folding intermediates by CCT/TriC";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Recruitment of NuMA to mitotic centrosomes";"Resolution of Sister Chromatid Cohesion";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Separation of Sister Chromatids";"Aggrephagy";"Cilium Assembly";"COPI-dependent Golgi-to-ER retrograde traffic";"EML4 and NUDC in mitotic spindle formation";"Mitotic Prometaphase";"Post-chaperonin tubulin folding pathway";"COPI-mediated anterograde transport";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Gap junction assembly";"Activation of AMPK downstream of NMDARs";"Recycling pathway of L1";"Carboxyterminal post-translational modifications of tubulin";"HCMV Early Events";"COPI-independent Golgi-to-ER retrograde traffic";"RHO GTPases activate IQGAPs";"MHC class II antigen presentation";"Kinesins";"Assembly and cell surface presentation of NMDA receptors";"The role of GTSE1 in G2/M progression after G2 checkpoint"
Medex_00060752-RA	1	KEGG: 00760+2.3.1.286	"Nicotinate and nicotinamide metabolism"
Medex_00038404-RA	1	Reactome: R-HSA-6787450	"tRNA modification in the mitochondrion"
Medex_00009571-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Medex_00070355-RA	2	Reactome: R-HSA-3238698;Reactome: R-HSA-373080	"WNT ligand biogenesis and trafficking";"Class B/2 (Secretin family receptors)"
Medex_00081789-RA	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
Medex_00014029-RA	33	Reactome: R-HSA-168271;Reactome: R-HSA-3232142;Reactome: R-HSA-170822;Reactome: R-HSA-4551638;Reactome: R-HSA-141444;Reactome: R-HSA-191859;Reactome: R-HSA-168325;Reactome: R-HSA-168333;Reactome: R-HSA-2467813;Reactome: R-HSA-1169408;Reactome: R-HSA-68877;Reactome: R-HSA-159231;Reactome: R-HSA-9648025;Reactome: R-HSA-159227;Reactome: R-HSA-5663220;Reactome: R-HSA-159230;Reactome: R-HSA-180910;Reactome: R-HSA-3301854;Reactome: R-HSA-4085377;Reactome: R-HSA-4570464;Reactome: R-HSA-5619107;Reactome: R-HSA-9610379;Reactome: R-HSA-9609690;Reactome: R-HSA-6784531;Reactome: R-HSA-3108214;Reactome: R-HSA-159236;Reactome: R-HSA-165054;Reactome: R-HSA-180746;Reactome: R-HSA-4615885;Reactome: R-HSA-3371453;Reactome: R-HSA-5578749;Reactome: R-HSA-168276;Reactome: R-HSA-2500257	"Transport of Ribonucleoproteins into the Host Nucleus";"SUMOylation of ubiquitinylation proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"SUMOylation of chromatin organization proteins";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"snRNP Assembly";"Viral Messenger RNA Synthesis";"NEP/NS2 Interacts with the Cellular Export Machinery";"Separation of Sister Chromatids";"ISG15 antiviral mechanism";"Mitotic Prometaphase";"Transport of Mature mRNA Derived from an Intronless Transcript";"EML4 and NUDC in mitotic spindle formation";"Transport of the SLBP independent Mature mRNA";"RHO GTPases Activate Formins";"Transport of the SLBP Dependant Mature mRNA";"Vpr-mediated nuclear import of PICs";"Nuclear Pore Complex (NPC) Disassembly";"SUMOylation of SUMOylation proteins";"SUMOylation of RNA binding proteins";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"HCMV Late Events";"HCMV Early Events";"tRNA processing in the nucleus";"SUMOylation of DNA damage response and repair proteins";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Rev-mediated nuclear export of HIV RNA";"Nuclear import of Rev protein";"SUMOylation of DNA replication proteins";"Regulation of HSF1-mediated heat shock response";"Transcriptional regulation by small RNAs";"NS1 Mediated Effects on Host Pathways";"Resolution of Sister Chromatid Cohesion"
Medex_00077446-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Medex_00007283-RA	3	MetaCyc: PWY-3961;Reactome: R-HSA-196783;KEGG: 00770+2.7.1.33	"Phosphopantothenate biosynthesis II";"Coenzyme A biosynthesis";"Pantothenate and CoA biosynthesis"
Medex_00017072-RA	9	KEGG: 00603+3.2.1.52;MetaCyc: PWY-7883;MetaCyc: PWY-6902;KEGG: 00531+3.2.1.52;KEGG: 00520+3.2.1.52;KEGG: 00513+3.2.1.52;MetaCyc: PWY-7822;KEGG: 00511+3.2.1.52;KEGG: 00604+3.2.1.52	"Glycosphingolipid biosynthesis - globo and isoglobo series";"Anhydromuropeptides recycling II";"Chitin degradation II (Vibrio)";"Glycosaminoglycan degradation";"Amino sugar and nucleotide sugar metabolism";"Various types of N-glycan biosynthesis";"Chitin degradation III (Serratia)";"Other glycan degradation";"Glycosphingolipid biosynthesis - ganglio series"
Medex_00022564-RA	2	KEGG: 00860+4.99.1.1;Reactome: R-HSA-189451	"Porphyrin and chlorophyll metabolism";"Heme biosynthesis"
Medex_00028898-RA	2	Reactome: R-HSA-5689603;Reactome: R-HSA-5696394	"UCH proteinases";"DNA Damage Recognition in GG-NER"
Medex_00000127-RA	13	Reactome: R-HSA-381676;Reactome: R-HSA-5218921;Reactome: R-HSA-5607763;Reactome: R-HSA-5578775;Reactome: R-HSA-114508;Reactome: R-HSA-2871809;Reactome: R-HSA-4086398;Reactome: R-HSA-422356;Reactome: R-HSA-112043;Reactome: R-HSA-2029485;Reactome: R-HSA-139853;Reactome: R-HSA-983695;Reactome: R-HSA-1489509	"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"VEGFR2 mediated cell proliferation";"CLEC7A (Dectin-1) induces NFAT activation";"Ion homeostasis";"Effects of PIP2 hydrolysis";"FCERI mediated Ca+2 mobilization";"Ca2+ pathway";"Regulation of insulin secretion";"PLC beta mediated events";"Role of phospholipids in phagocytosis";"Elevation of cytosolic Ca2+ levels";"Antigen activates B Cell Receptor (BCR) leading to generation of second messengers";"DAG and IP3 signaling"
Medex_00015766-RA	3	Reactome: R-HSA-391160;Reactome: R-HSA-4420097;KEGG: 04660+2.7.10.2	"Signal regulatory protein family interactions";"VEGFA-VEGFR2 Pathway";"T cell receptor signaling pathway"
Medex_00067951-RA	2	Reactome: R-HSA-6811436;Reactome: R-HSA-8876198	"COPI-independent Golgi-to-ER retrograde traffic";"RAB GEFs exchange GTP for GDP on RABs"
Medex_00010833-RA	1	Reactome: R-HSA-8949664	"Processing of SMDT1"
Medex_00092310-RA	4	Reactome: R-HSA-72163;Reactome: R-HSA-77595;Reactome: R-HSA-73856;Reactome: R-HSA-72187	"mRNA Splicing - Major Pathway";"Processing of Intronless Pre-mRNAs";"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing"
Medex_00030320-RA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
Medex_00015081-RA	13	Reactome: R-HSA-71403;MetaCyc: PWY-5538;KEGG: 00020+6.2.1.5;KEGG: 00720+6.2.1.5;MetaCyc: PWY-5392;KEGG: 00640+6.2.1.5;KEGG: 00660+6.2.1.5;MetaCyc: PWY-5690;MetaCyc: PWY-7384;MetaCyc: PWY-5537;MetaCyc: PWY-6728;MetaCyc: PWY-6969;MetaCyc: PWY-5913	"Citric acid cycle (TCA cycle)";"Pyruvate fermentation to acetate VI";"Citrate cycle (TCA cycle)";"Carbon fixation pathways in prokaryotes";"Reductive TCA cycle II";"Propanoate metabolism";"C5-Branched dibasic acid metabolism";"TCA cycle II (plants and fungi)";"Anaerobic energy metabolism (invertebrates, mitochondrial)";"Pyruvate fermentation to acetate V";"Methylaspartate cycle";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Partial TCA cycle (obligate autotrophs)"
Medex_00066851-RA	1	Reactome: R-HSA-3299685	"Detoxification of Reactive Oxygen Species"
Medex_00044111-RA	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
Medex_00014018-RA	2	KEGG: 00450+6.1.1.10;KEGG: 00970+6.1.1.10	"Selenocompound metabolism";"Aminoacyl-tRNA biosynthesis"
Medex_00013646-RA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00046665-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Medex_00005365-RA	6	KEGG: 00511+3.2.1.23;KEGG: 00600+3.2.1.23;MetaCyc: PWY-6807;KEGG: 00604+3.2.1.23;KEGG: 00531+3.2.1.23;KEGG: 00052+3.2.1.23	"Other glycan degradation";"Sphingolipid metabolism";"Xyloglucan degradation II (exoglucanase)";"Glycosphingolipid biosynthesis - ganglio series";"Glycosaminoglycan degradation";"Galactose metabolism"
Medex_00068337-RA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
Medex_00046911-RA	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5419276;Reactome: R-HSA-5368286	"Mitochondrial translation elongation";"Mitochondrial translation termination";"Mitochondrial translation initiation"
Medex_00015632-RA	1	Reactome: R-HSA-9033241	"Peroxisomal protein import"
Medex_00033855-RA	1	KEGG: 00970+6.1.1.14	"Aminoacyl-tRNA biosynthesis"
Medex_00034935-RA	7	KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1	"Human papillomavirus infection";"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Human cytomegalovirus infection";"Thermogenesis";"Relaxin signaling pathway"
Medex_00035037-RA	2	Reactome: R-HSA-8949664;Reactome: R-HSA-8949215	"Processing of SMDT1";"Mitochondrial calcium ion transport"
Medex_00009669-RA	3	Reactome: R-HSA-6798695;MetaCyc: PWY-6807;KEGG: 00511+3.2.1.51	"Neutrophil degranulation";"Xyloglucan degradation II (exoglucanase)";"Other glycan degradation"
Medex_00052575-RA	2	Reactome: R-HSA-877300;Reactome: R-HSA-2132295	"Interferon gamma signaling";"MHC class II antigen presentation"
Medex_00020566-RA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
Medex_00048374-RA	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
Medex_00030823-RA	11	KEGG: 00740+3.6.1.9;KEGG: 00240+3.6.1.9;MetaCyc: PWY-7821;KEGG: 00230+3.6.1.9;MetaCyc: PWY-6545;MetaCyc: PWY-7187;MetaCyc: PWY-7184;KEGG: 00760+3.6.1.9;KEGG: 00770+3.6.1.9;KEGG: 00500+3.6.1.9;MetaCyc: PWY-7206	"Riboflavin metabolism";"Pyrimidine metabolism";"Tunicamycin biosynthesis";"Purine metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Pyrimidine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Nicotinate and nicotinamide metabolism";"Pantothenate and CoA biosynthesis";"Starch and sucrose metabolism";"Pyrimidine deoxyribonucleotides dephosphorylation"
Medex_00005653-RA	1	Reactome: R-HSA-216083	"Integrin cell surface interactions"
MedexCellulase01-PA	2	MetaCyc: PWY-6788;KEGG: 00500+3.2.1.4	"Cellulose degradation II (fungi)";"Starch and sucrose metabolism"
Medex_00016118-RA	1	Reactome: R-HSA-5620922	"BBSome-mediated cargo-targeting to cilium"
Medex_00078417-RA	1	Reactome: R-HSA-1799339	"SRP-dependent cotranslational protein targeting to membrane"
Medex_00053484-RA	1	Reactome: R-HSA-6811434	"COPI-dependent Golgi-to-ER retrograde traffic"
Medex_00049167-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Medex_00070321-RA	5	Reactome: R-HSA-4641257;Reactome: R-HSA-5545619;Reactome: R-HSA-201681;Reactome: R-HSA-8948751;Reactome: R-HSA-5689880	"Degradation of AXIN";"XAV939 inhibits tankyrase, stabilizing AXIN";"TCF dependent signaling in response to WNT";"Regulation of PTEN stability and activity";"Ub-specific processing proteases"
Medex_00086885-RA	5	MetaCyc: PWY-3821;KEGG: 00052+2.7.1.6;MetaCyc: PWY-6527;KEGG: 00520+2.7.1.6;MetaCyc: PWY-6317	"D-galactose detoxification";"Galactose metabolism";"Stachyose degradation";"Amino sugar and nucleotide sugar metabolism";"D-galactose degradation I (Leloir pathway)"
Medex_00042494-RA	2	Reactome: R-HSA-8876198;Reactome: R-HSA-204005	"RAB GEFs exchange GTP for GDP on RABs";"COPII-mediated vesicle transport"
Medex_00047948-RA	26	Reactome: R-HSA-3371497;Reactome: R-HSA-2500257;Reactome: R-HSA-380320;Reactome: R-HSA-1445148;Reactome: R-HSA-389960;Reactome: R-HSA-5663220;Reactome: R-HSA-389977;Reactome: R-HSA-68877;Reactome: R-HSA-9648025;Reactome: R-HSA-6811434;Reactome: R-HSA-5617833;Reactome: R-HSA-9646399;Reactome: R-HSA-2467813;Reactome: R-HSA-2132295;Reactome: R-HSA-5626467;Reactome: R-HSA-6811436;Reactome: R-HSA-9609690;Reactome: R-HSA-8955332;Reactome: R-HSA-190840;Reactome: R-HSA-6807878;Reactome: R-HSA-437239;Reactome: R-HSA-190861;Reactome: R-HSA-9619483;Reactome: R-HSA-8852276;Reactome: R-HSA-9609736;Reactome: R-HSA-983189	"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Resolution of Sister Chromatid Cohesion";"Recruitment of NuMA to mitotic centrosomes";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Formation of tubulin folding intermediates by CCT/TriC";"RHO GTPases Activate Formins";"Post-chaperonin tubulin folding pathway";"Mitotic Prometaphase";"EML4 and NUDC in mitotic spindle formation";"COPI-dependent Golgi-to-ER retrograde traffic";"Cilium Assembly";"Aggrephagy";"Separation of Sister Chromatids";"MHC class II antigen presentation";"RHO GTPases activate IQGAPs";"COPI-independent Golgi-to-ER retrograde traffic";"HCMV Early Events";"Carboxyterminal post-translational modifications of tubulin";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"COPI-mediated anterograde transport";"Recycling pathway of L1";"Gap junction assembly";"Activation of AMPK downstream of NMDARs";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Assembly and cell surface presentation of NMDA receptors";"Kinesins"
Medex_00008358-RA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Medex_00045042-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Medex_00005469-RA	2	Reactome: R-HSA-8853383;KEGG: 00511+3.2.1.24	"Lysosomal oligosaccharide catabolism";"Other glycan degradation"
Medex_00084260-RA	1	Reactome: R-HSA-499943	"Interconversion of nucleotide di- and triphosphates"
Medex_00007586-RA	2	Reactome: R-HSA-2514859;KEGG: 00900+2.5.1.58	"Inactivation, recovery and regulation of the phototransduction cascade";"Terpenoid backbone biosynthesis"
Medex_00064638-RA	1	Reactome: R-HSA-202733	"Cell surface interactions at the vascular wall"
Medex_00055657-RA	32	Reactome: R-HSA-75955;Reactome: R-HSA-9018519;Reactome: R-HSA-167200;Reactome: R-HSA-167160;Reactome: R-HSA-167246;Reactome: R-HSA-167242;Reactome: R-HSA-72163;Reactome: R-HSA-167172;Reactome: R-HSA-167290;Reactome: R-HSA-112382;Reactome: R-HSA-73779;Reactome: R-HSA-8851708;Reactome: R-HSA-75953;Reactome: R-HSA-167161;Reactome: R-HSA-113418;Reactome: R-HSA-6807505;Reactome: R-HSA-167162;Reactome: R-HSA-76042;Reactome: R-HSA-72165;Reactome: R-HSA-167243;Reactome: R-HSA-167287;Reactome: R-HSA-674695;Reactome: R-HSA-167152;Reactome: R-HSA-73776;Reactome: R-HSA-72086;Reactome: R-HSA-167238;Reactome: R-HSA-6796648;Reactome: R-HSA-72203;Reactome: R-HSA-168325;Reactome: R-HSA-77075;Reactome: R-HSA-167158;Reactome: R-HSA-6803529	"RNA Polymerase II Transcription Elongation";"Estrogen-dependent gene expression";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Tat-mediated elongation of the HIV-1 transcript";"Abortive elongation of HIV-1 transcript in the absence of Tat";"mRNA Splicing - Major Pathway";"Transcription of the HIV genome";"Pausing and recovery of HIV elongation";"Formation of RNA Pol II elongation complex";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Signaling by FGFR2 IIIa TM";"RNA Polymerase II Transcription Initiation";"HIV Transcription Initiation";"Formation of the Early Elongation Complex";"RNA polymerase II transcribes snRNA genes";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"mRNA Splicing - Minor Pathway";"Tat-mediated HIV elongation arrest and recovery";"HIV elongation arrest and recovery";"RNA Polymerase II Pre-transcription Events";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Polymerase II Promoter Escape";"mRNA Capping";"Pausing and recovery of Tat-mediated HIV elongation";"TP53 Regulates Transcription of DNA Repair Genes";"Processing of Capped Intron-Containing Pre-mRNA";"Viral Messenger RNA Synthesis";"RNA Pol II CTD phosphorylation and interaction with CE";"Formation of the HIV-1 Early Elongation Complex";"FGFR2 alternative splicing"
Medex_00055245-RA	1	Reactome: R-HSA-9633012	"Response of EIF2AK4 (GCN2) to amino acid deficiency"
Medex_00037520-RA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
Medex_00000888-RA	3	MetaCyc: PWY-8106;MetaCyc: PWY-6700;Reactome: R-HSA-6782315	"Queuosine biosynthesis III (queuosine salvage)";"Queuosine biosynthesis I (de novo)";"tRNA modification in the nucleus and cytosol"
Medex_00008251-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Medex_00029764-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Medex_00005233-RA	1	Reactome: R-HSA-1660662	"Glycosphingolipid metabolism"
Medex_00080123-RA	7	MetaCyc: PWY-6367;MetaCyc: PWY-8052;KEGG: 04070+3.1.4.11;Reactome: R-HSA-1855204;KEGG: 00562+3.1.4.11;MetaCyc: PWY-7039;MetaCyc: PWY-6351	"D-myo-inositol-5-phosphate metabolism";"2-arachidonoylglycerol biosynthesis";"Phosphatidylinositol signaling system";"Synthesis of IP3 and IP4 in the cytosol";"Inositol phosphate metabolism";"Phosphatidate metabolism, as a signaling molecule";"D-myo-inositol (1,4,5)-trisphosphate biosynthesis"
Medex_00006288-RA	15	Reactome: R-HSA-8986944;Reactome: R-HSA-8936459;Reactome: R-HSA-8934593;Reactome: R-HSA-5687128;Reactome: R-HSA-9018519;Reactome: R-HSA-1912408;Reactome: R-HSA-5628897;Reactome: R-HSA-2559585;Reactome: R-HSA-8948700;Reactome: R-HSA-4086398;Reactome: R-HSA-9029569;Reactome: R-HSA-9022692;Reactome: R-HSA-8943723;Reactome: R-HSA-8853884;Reactome: R-HSA-2559580	"Transcriptional Regulation by MECP2";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Regulation of RUNX1 Expression and Activity";"MAPK6/MAPK4 signaling";"Estrogen-dependent gene expression";"Pre-NOTCH Transcription and Translation";"TP53 Regulates Metabolic Genes";"Oncogene Induced Senescence";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"Ca2+ pathway";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Regulation of MECP2 expression and activity";"Regulation of PTEN mRNA translation";"Transcriptional Regulation by VENTX";"Oxidative Stress Induced Senescence"
Medex_00004768-RA	3	Reactome: R-HSA-5694530;Reactome: R-HSA-204005;Reactome: R-HSA-948021	"Cargo concentration in the ER";"COPII-mediated vesicle transport";"Transport to the Golgi and subsequent modification"
Medex_00055693-RA	12	Reactome: R-HSA-167246;Reactome: R-HSA-6804756;Reactome: R-HSA-167200;Reactome: R-HSA-167238;Reactome: R-HSA-6796648;Reactome: R-HSA-75955;Reactome: R-HSA-112382;Reactome: R-HSA-167152;Reactome: R-HSA-674695;Reactome: R-HSA-167243;Reactome: R-HSA-167287;Reactome: R-HSA-167290	"Tat-mediated elongation of the HIV-1 transcript";"Regulation of TP53 Activity through Phosphorylation";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Pausing and recovery of Tat-mediated HIV elongation";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Transcription Elongation";"Formation of RNA Pol II elongation complex";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Polymerase II Pre-transcription Events";"Tat-mediated HIV elongation arrest and recovery";"HIV elongation arrest and recovery";"Pausing and recovery of HIV elongation"
Medex_00027949-RA	12	MetaCyc: PWY-6969;MetaCyc: PWY-5913;MetaCyc: PWY-6728;MetaCyc: PWY-5537;MetaCyc: PWY-5690;KEGG: 00660+6.2.1.5;MetaCyc: PWY-7384;KEGG: 00720+6.2.1.5;KEGG: 00640+6.2.1.5;MetaCyc: PWY-5392;MetaCyc: PWY-5538;KEGG: 00020+6.2.1.5	"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Partial TCA cycle (obligate autotrophs)";"Methylaspartate cycle";"Pyruvate fermentation to acetate V";"TCA cycle II (plants and fungi)";"C5-Branched dibasic acid metabolism";"Anaerobic energy metabolism (invertebrates, mitochondrial)";"Carbon fixation pathways in prokaryotes";"Propanoate metabolism";"Reductive TCA cycle II";"Pyruvate fermentation to acetate VI";"Citrate cycle (TCA cycle)"
Medex_00018397-RA	4	Reactome: R-HSA-6798695;Reactome: R-HSA-2024096;Reactome: R-HSA-2206292;Reactome: R-HSA-2160916	"Neutrophil degranulation";"HS-GAG degradation";"MPS VII - Sly syndrome";"Hyaluronan uptake and degradation"
Medex_00092082-RA	1	Reactome: R-HSA-611105	"Respiratory electron transport"
Medex_00015082-RA	13	MetaCyc: PWY-5690;KEGG: 00660+6.2.1.5;MetaCyc: PWY-7384;MetaCyc: PWY-6969;MetaCyc: PWY-5913;MetaCyc: PWY-6728;MetaCyc: PWY-5537;Reactome: R-HSA-71403;KEGG: 00020+6.2.1.5;MetaCyc: PWY-5538;KEGG: 00720+6.2.1.5;KEGG: 00640+6.2.1.5;MetaCyc: PWY-5392	"TCA cycle II (plants and fungi)";"C5-Branched dibasic acid metabolism";"Anaerobic energy metabolism (invertebrates, mitochondrial)";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Partial TCA cycle (obligate autotrophs)";"Methylaspartate cycle";"Pyruvate fermentation to acetate V";"Citric acid cycle (TCA cycle)";"Citrate cycle (TCA cycle)";"Pyruvate fermentation to acetate VI";"Carbon fixation pathways in prokaryotes";"Propanoate metabolism";"Reductive TCA cycle II"
Medex_00036626-RA	5	Reactome: R-HSA-73772;Reactome: R-HSA-73863;Reactome: R-HSA-5250924;Reactome: R-HSA-427413;Reactome: R-HSA-73762	"RNA Polymerase I Promoter Escape";"RNA Polymerase I Transcription Termination";"B-WICH complex positively regulates rRNA expression";"NoRC negatively regulates rRNA expression";"RNA Polymerase I Transcription Initiation"
Medex_00035811-RA	1	Reactome: R-HSA-8951664	"Neddylation"
Medex_00072030-RA	3	Reactome: R-HSA-6798695;MetaCyc: PWY-6807;KEGG: 00511+3.2.1.51	"Neutrophil degranulation";"Xyloglucan degradation II (exoglucanase)";"Other glycan degradation"
Medex_00073043-RA	15	Reactome: R-HSA-674695;Reactome: R-HSA-167152;Reactome: R-HSA-9603505;Reactome: R-HSA-167243;Reactome: R-HSA-113418;Reactome: R-HSA-167287;Reactome: R-HSA-167158;Reactome: R-HSA-167290;Reactome: R-HSA-167242;Reactome: R-HSA-167246;Reactome: R-HSA-167200;Reactome: R-HSA-75955;Reactome: R-HSA-6796648;Reactome: R-HSA-167238;Reactome: R-HSA-112382	"RNA Polymerase II Pre-transcription Events";"Formation of HIV elongation complex in the absence of HIV Tat";"NTRK3 as a dependence receptor";"Tat-mediated HIV elongation arrest and recovery";"Formation of the Early Elongation Complex";"HIV elongation arrest and recovery";"Formation of the HIV-1 Early Elongation Complex";"Pausing and recovery of HIV elongation";"Abortive elongation of HIV-1 transcript in the absence of Tat";"Tat-mediated elongation of the HIV-1 transcript";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Polymerase II Transcription Elongation";"TP53 Regulates Transcription of DNA Repair Genes";"Pausing and recovery of Tat-mediated HIV elongation";"Formation of RNA Pol II elongation complex"
Medex_00054568-RA	3	MetaCyc: PWY-7511;Reactome: R-HSA-8866654;Reactome: R-HSA-110314	"Protein ubiquitination";"E3 ubiquitin ligases ubiquitinate target proteins";"Recognition of DNA damage by PCNA-containing replication complex"
Medex_00003951-RA	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
Medex_00031770-RA	4	Reactome: R-HSA-8951664;Reactome: R-HSA-5696394;Reactome: R-HSA-6781823;Reactome: R-HSA-8856825	"Neddylation";"DNA Damage Recognition in GG-NER";"Formation of TC-NER Pre-Incision Complex";"Cargo recognition for clathrin-mediated endocytosis"
Medex_00038166-RA	15	MetaCyc: PWY-6886;Reactome: R-HSA-70171;KEGG: 00230+2.7.1.40;MetaCyc: PWY-2221;MetaCyc: PWY-6901;KEGG: 00620+2.7.1.40;MetaCyc: PWY-6142;MetaCyc: PWY-7003;MetaCyc: PWY-5723;MetaCyc: PWY-1042;MetaCyc: PWY-8004;MetaCyc: PWY-7383;MetaCyc: PWY-7218;KEGG: 00010+2.7.1.40;MetaCyc: PWY-5484	"1-butanol autotrophic biosynthesis (engineered)";"Glycolysis";"Purine metabolism";"Entner-Doudoroff pathway III (semi-phosphorylative)";"Superpathway of glucose and xylose degradation";"Pyruvate metabolism";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Glycerol degradation to butanol";"Rubisco shunt";"Glycolysis IV (plant cytosol)";"Entner-Doudoroff pathway I";"Anaerobic energy metabolism (invertebrates, cytosol)";"Photosynthetic 3-hydroxybutanoate biosynthesis (engineered)";"Glycolysis / Gluconeogenesis";"Glycolysis II (from fructose 6-phosphate)"
Medex_00099318-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Medex_00025990-RA	2	Reactome: R-HSA-381340;Reactome: R-HSA-1989781	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression"
Medex_00017180-RA	3	Reactome: R-HSA-71336;KEGG: 00030+1.1.1.44;KEGG: 00480+1.1.1.44	"Pentose phosphate pathway";"Pentose phosphate pathway";"Glutathione metabolism"
Medex_00084539-RA	1	Reactome: R-HSA-9617828	"FOXO-mediated transcription of cell cycle genes"
Medex_00056925-RA	27	Reactome: R-HSA-6784531;Reactome: R-HSA-3108214;Reactome: R-HSA-159236;Reactome: R-HSA-191859;Reactome: R-HSA-168325;Reactome: R-HSA-9610379;Reactome: R-HSA-5619107;Reactome: R-HSA-4551638;Reactome: R-HSA-9609690;Reactome: R-HSA-4085377;Reactome: R-HSA-4570464;Reactome: R-HSA-170822;Reactome: R-HSA-180910;Reactome: R-HSA-168271;Reactome: R-HSA-3301854;Reactome: R-HSA-3232142;Reactome: R-HSA-168276;Reactome: R-HSA-5578749;Reactome: R-HSA-159230;Reactome: R-HSA-4615885;Reactome: R-HSA-3371453;Reactome: R-HSA-159231;Reactome: R-HSA-159227;Reactome: R-HSA-180746;Reactome: R-HSA-168333;Reactome: R-HSA-1169408;Reactome: R-HSA-165054	"tRNA processing in the nucleus";"SUMOylation of DNA damage response and repair proteins";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"snRNP Assembly";"Viral Messenger RNA Synthesis";"HCMV Late Events";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"SUMOylation of chromatin organization proteins";"HCMV Early Events";"SUMOylation of SUMOylation proteins";"SUMOylation of RNA binding proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Vpr-mediated nuclear import of PICs";"Transport of Ribonucleoproteins into the Host Nucleus";"Nuclear Pore Complex (NPC) Disassembly";"SUMOylation of ubiquitinylation proteins";"NS1 Mediated Effects on Host Pathways";"Transcriptional regulation by small RNAs";"Transport of the SLBP Dependant Mature mRNA";"SUMOylation of DNA replication proteins";"Regulation of HSF1-mediated heat shock response";"Transport of Mature mRNA Derived from an Intronless Transcript";"Transport of the SLBP independent Mature mRNA";"Nuclear import of Rev protein";"NEP/NS2 Interacts with the Cellular Export Machinery";"ISG15 antiviral mechanism";"Rev-mediated nuclear export of HIV RNA"
Medex_00058704-RA	12	MetaCyc: PWY-5873;MetaCyc: PWY-5871;MetaCyc: PWY-5857;MetaCyc: PWY-6708;MetaCyc: PWY-7230;MetaCyc: PWY-5855;MetaCyc: PWY-7233;MetaCyc: PWY-5856;MetaCyc: PWY-5870;MetaCyc: PWY-5872;Reactome: R-HSA-2142789;KEGG: 00130+2.1.1.222+2.1.1.64	"Ubiquinol-7 biosynthesis (eukaryotic)";"Ubiquinol-9 biosynthesis (eukaryotic)";"Ubiquinol-10 biosynthesis (prokaryotic)";"Ubiquinol-8 biosynthesis (prokaryotic)";"Ubiquinol-6 biosynthesis from 4-aminobenzoate (yeast)";"Ubiquinol-7 biosynthesis (prokaryotic)";"Ubiquinol-6 bypass biosynthesis (eukaryotic)";"Ubiquinol-9 biosynthesis (prokaryotic)";"Ubiquinol-8 biosynthesis (eukaryotic)";"Ubiquinol-10 biosynthesis (eukaryotic)";"Ubiquinol biosynthesis";"Ubiquinone and other terpenoid-quinone biosynthesis"
Medex_00011885-RA	6	Reactome: R-HSA-5358606;Reactome: R-HSA-912446;Reactome: R-HSA-6796648;Reactome: R-HSA-5632987;Reactome: R-HSA-5545483;Reactome: R-HSA-5358565	"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"Meiotic recombination";"TP53 Regulates Transcription of DNA Repair Genes";"Defective Mismatch Repair Associated With PMS2";"Defective Mismatch Repair Associated With MLH1";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)"
Medex_00032327-RA	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
Medex_00073290-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00004388-RA	6	MetaCyc: PWY-6807;KEGG: 00600+3.2.1.23;KEGG: 00511+3.2.1.23;KEGG: 00604+3.2.1.23;KEGG: 00052+3.2.1.23;KEGG: 00531+3.2.1.23	"Xyloglucan degradation II (exoglucanase)";"Sphingolipid metabolism";"Other glycan degradation";"Glycosphingolipid biosynthesis - ganglio series";"Galactose metabolism";"Glycosaminoglycan degradation"
Medex_00044423-RA	4	MetaCyc: PWY-6829;MetaCyc: PWY-7285;Reactome: R-HSA-6782315;MetaCyc: PWY-7286	"Trna methylation (yeast)";"Methylwyosine biosynthesis";"tRNA modification in the nucleus and cytosol";"7-(3-amino-3-carboxypropyl)-wyosine biosynthesis"
Medex_00021549-RA	7	KEGG: 00480+2.5.1.22;KEGG: 00270+2.5.1.16;KEGG: 00330+2.5.1.16;KEGG: 00480+2.5.1.16;Reactome: R-HSA-351202;KEGG: 00330+2.5.1.22;KEGG: 00270+2.5.1.22	"Glutathione metabolism";"Cysteine and methionine metabolism";"Arginine and proline metabolism";"Glutathione metabolism";"Metabolism of polyamines";"Arginine and proline metabolism";"Cysteine and methionine metabolism"
Medex_00054596-RA	1	Reactome: R-HSA-1971475	"A tetrasaccharide linker sequence is required for GAG synthesis"
Medex_00070060-RA	3	Reactome: R-HSA-5083627;Reactome: R-HSA-5173105;Reactome: R-HSA-2022854	"Defective LARGE causes MDDGA6 and MDDGB6";"O-linked glycosylation";"Keratan sulfate biosynthesis"
Medex_00008932-RA	1	Reactome: R-HSA-6798163	"Choline catabolism"
Medex_00095488-RA	10	MetaCyc: PWY-7003;MetaCyc: PWY-6901;KEGG: 00010+2.7.2.3;MetaCyc: PWY-1042;Reactome: R-HSA-70171;MetaCyc: PWY-6886;Reactome: R-HSA-70263;MetaCyc: PWY-5484;KEGG: 00710+2.7.2.3;MetaCyc: PWY-8004	"Glycerol degradation to butanol";"Superpathway of glucose and xylose degradation";"Glycolysis / Gluconeogenesis";"Glycolysis IV (plant cytosol)";"Glycolysis";"1-butanol autotrophic biosynthesis (engineered)";"Gluconeogenesis";"Glycolysis II (from fructose 6-phosphate)";"Carbon fixation in photosynthetic organisms";"Entner-Doudoroff pathway I"
Medex_00080030-RA	4	Reactome: R-HSA-3371497;Reactome: R-HSA-3371568;Reactome: R-HSA-8939211;Reactome: R-HSA-9018519	"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Attenuation phase";"ESR-mediated signaling";"Estrogen-dependent gene expression"
Medex_00037994-RA	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
Medex_00076374-RA	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
Medex_00023489-RA	5	Reactome: R-HSA-6782210;Reactome: R-HSA-6781827;Reactome: R-HSA-72163;Reactome: R-HSA-6782135;Reactome: R-HSA-6781823	"Gap-filling DNA repair synthesis and ligation in TC-NER";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"mRNA Splicing - Major Pathway";"Dual incision in TC-NER";"Formation of TC-NER Pre-Incision Complex"
Medex_00044566-RA	6	KEGG: 00604+3.2.1.23;KEGG: 00511+3.2.1.23;KEGG: 00600+3.2.1.23;MetaCyc: PWY-6807;KEGG: 00531+3.2.1.23;KEGG: 00052+3.2.1.23	"Glycosphingolipid biosynthesis - ganglio series";"Other glycan degradation";"Sphingolipid metabolism";"Xyloglucan degradation II (exoglucanase)";"Glycosaminoglycan degradation";"Galactose metabolism"
Medex_00046872-RA	1	Reactome: R-HSA-912446	"Meiotic recombination"
Medex_00091975-RA	1	Reactome: R-HSA-1445148	"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
Medex_00000486-RA	2	Reactome: R-HSA-1660662;Reactome: R-HSA-390471	"Glycosphingolipid metabolism";"Association of TriC/CCT with target proteins during biosynthesis"
Medex_00026585-RA	1	Reactome: R-HSA-432722	"Golgi Associated Vesicle Biogenesis"
Medex_00005633-RA	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
Medex_00019757-RA	1	Reactome: R-HSA-5663220	"RHO GTPases Activate Formins"
Medex_00037395-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Medex_00064820-RA	8	Reactome: R-HSA-1222556;Reactome: R-HSA-9639288;Reactome: R-HSA-77387;Reactome: R-HSA-983712;Reactome: R-HSA-917977;KEGG: 00190+7.1.2.2;KEGG: 00195+7.1.2.2;MetaCyc: PWY-7980	"ROS and RNS production in phagocytes";"Amino acids regulate mTORC1";"Insulin receptor recycling";"Ion channel transport";"Transferrin endocytosis and recycling";"Oxidative phosphorylation";"Photosynthesis";"ATP biosynthesis"
Medex_00002003-RA	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
Medex_00011044-RA	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
Medex_00055834-RA	5	Reactome: R-HSA-204005;Reactome: R-HSA-2132295;Reactome: R-HSA-5694530;Reactome: R-HSA-1655829;Reactome: R-HSA-983170	"COPII-mediated vesicle transport";"MHC class II antigen presentation";"Cargo concentration in the ER";"Regulation of cholesterol biosynthesis by SREBP (SREBF)";"Antigen Presentation: Folding, assembly and peptide loading of class I MHC"
Medex_00095773-RA	1	Reactome: R-HSA-2022928	"HS-GAG biosynthesis"
Medex_00021785-RA	1	Reactome: R-HSA-3299685	"Detoxification of Reactive Oxygen Species"
Medex_00009784-RA	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
Medex_00080947-RA	11	Reactome: R-HSA-5685938;Reactome: R-HSA-5693607;Reactome: R-HSA-5685942;Reactome: R-HSA-174437;Reactome: R-HSA-69166;Reactome: R-HSA-5693554;Reactome: R-HSA-5693616;Reactome: R-HSA-6804756;Reactome: R-HSA-5693579;Reactome: R-HSA-69473;Reactome: R-HSA-5693568	"HDR through Single Strand Annealing (SSA)";"Processing of DNA double-strand break ends";"HDR through Homologous Recombination (HRR)";"Removal of the Flap Intermediate from the C-strand";"Removal of the Flap Intermediate";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Presynaptic phase of homologous DNA pairing and strand exchange";"Regulation of TP53 Activity through Phosphorylation";"Homologous DNA Pairing and Strand Exchange";"G2/M DNA damage checkpoint";"Resolution of D-loop Structures through Holliday Junction Intermediates"
Medex_00065992-RA	2	MetaCyc: PWY-6281;KEGG: 00970+6.1.1.11	"L-selenocysteine biosynthesis II (archaea and eukaryotes)";"Aminoacyl-tRNA biosynthesis"
Medex_00070134-RA	1	Reactome: R-HSA-211981	"Xenobiotics"
Medex_00024254-RA	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
Medex_00010136-RA	6	Reactome: R-HSA-3000171;Reactome: R-HSA-2022090;Reactome: R-HSA-8948216;Reactome: R-HSA-1442490;Reactome: R-HSA-8874081;Reactome: R-HSA-1650814	"Non-integrin membrane-ECM interactions";"Assembly of collagen fibrils and other multimeric structures";"Collagen chain trimerization";"Collagen degradation";"MET activates PTK2 signaling";"Collagen biosynthesis and modifying enzymes"
Medex_00012615-RA	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
Medex_00048041-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00053249-RA	42	Reactome: R-HSA-8936459;Reactome: R-HSA-5625886;Reactome: R-HSA-3214842;Reactome: R-HSA-69473;Reactome: R-HSA-3214815;Reactome: R-HSA-110330;Reactome: R-HSA-5693565;Reactome: R-HSA-5693607;Reactome: R-HSA-8939236;Reactome: R-HSA-73728;Reactome: R-HSA-73772;Reactome: R-HSA-427413;Reactome: R-HSA-3214847;Reactome: R-HSA-201722;Reactome: R-HSA-4551638;Reactome: R-HSA-9616222;Reactome: R-HSA-912446;Reactome: R-HSA-3214858;Reactome: R-HSA-3214841;Reactome: R-HSA-427389;Reactome: R-HSA-5578749;Reactome: R-HSA-2559582;Reactome: R-HSA-5617472;Reactome: R-HSA-2559586;Reactome: R-HSA-9018519;Reactome: R-HSA-5250924;Reactome: R-HSA-212300;Reactome: R-HSA-110331;Reactome: R-HSA-606279;Reactome: R-HSA-1221632;Reactome: R-HSA-2559580;Reactome: R-HSA-110329;Reactome: R-HSA-171306;Reactome: R-HSA-427359;Reactome: R-HSA-5334118;Reactome: R-HSA-9609690;Reactome: R-HSA-9610379;Reactome: R-HSA-1912408;Reactome: R-HSA-5693571;Reactome: R-HSA-977225;Reactome: R-HSA-110328;Reactome: R-HSA-2299718	"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3";"HDMs demethylate histones";"G2/M DNA damage checkpoint";"HDACs deacetylate histones";"Recognition and association of DNA glycosylase with site containing an affected purine";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Processing of DNA double-strand break ends";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"RNA Polymerase I Promoter Opening";"RNA Polymerase I Promoter Escape";"NoRC negatively regulates rRNA expression";"HATs acetylate histones";"Formation of the beta-catenin:TCF transactivating complex";"SUMOylation of chromatin organization proteins";"Transcriptional regulation of granulopoiesis";"Meiotic recombination";"RMTs methylate histone arginines";"PKMTs methylate histone lysines";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"Transcriptional regulation by small RNAs";"Senescence-Associated Secretory Phenotype (SASP)";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"DNA Damage/Telomere Stress Induced Senescence";"Estrogen-dependent gene expression";"B-WICH complex positively regulates rRNA expression";"PRC2 methylates histones and DNA";"Cleavage of the damaged purine";"Deposition of new CENPA-containing nucleosomes at the centromere";"Meiotic synapsis";"Oxidative Stress Induced Senescence";"Cleavage of the damaged pyrimidine";"Packaging Of Telomere Ends";"SIRT1 negatively regulates rRNA expression";"DNA methylation";"HCMV Early Events";"HCMV Late Events";"Pre-NOTCH Transcription and Translation";"Nonhomologous End-Joining (NHEJ)";"Amyloid fiber formation";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"Condensation of Prophase Chromosomes"
Medex_00020565-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Medex_00060577-RA	8	MetaCyc: PWY-4983;MetaCyc: PWY-7400;Reactome: R-HSA-70635;MetaCyc: PWY-4984;MetaCyc: PWY-5;MetaCyc: PWY-5154;KEGG: 00250+4.3.2.1;KEGG: 00220+4.3.2.1	"Nitric oxide biosynthesis II (mammals)";"L-arginine biosynthesis IV (archaebacteria)";"Urea cycle";"Urea cycle";"Canavanine biosynthesis";"L-arginine biosynthesis III (via N-acetyl-L-citrulline)";"Alanine, aspartate and glutamate metabolism";"Arginine biosynthesis"
Medex_00071100-RA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
Medex_00046119-RA	1	KEGG: 00900+3.4.24.84	"Terpenoid backbone biosynthesis"
Medex_00022436-RA	5	Reactome: R-HSA-75955;Reactome: R-HSA-8866654;Reactome: R-HSA-112382;Reactome: R-HSA-674695;Reactome: R-HSA-201722	"RNA Polymerase II Transcription Elongation";"E3 ubiquitin ligases ubiquitinate target proteins";"Formation of RNA Pol II elongation complex";"RNA Polymerase II Pre-transcription Events";"Formation of the beta-catenin:TCF transactivating complex"
Medex_00015627-RA	2	Reactome: R-HSA-8853659;Reactome: R-HSA-5673001	"RET signaling";"RAF/MAP kinase cascade"
Medex_00003729-RA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
Medex_00061181-RA	2	Reactome: R-HSA-1660662;Reactome: R-HSA-390471	"Glycosphingolipid metabolism";"Association of TriC/CCT with target proteins during biosynthesis"
Medex_00044276-RA	2	Reactome: R-HSA-383280;Reactome: R-HSA-983231	"Nuclear Receptor transcription pathway";"Factors involved in megakaryocyte development and platelet production"
Medex_00051996-RA	5	Reactome: R-HSA-5617472;Reactome: R-HSA-3214841;Reactome: R-HSA-201722;Reactome: R-HSA-8936459;Reactome: R-HSA-3769402	"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"PKMTs methylate histone lysines";"Formation of the beta-catenin:TCF transactivating complex";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Deactivation of the beta-catenin transactivating complex"
Medex_00010306-RA	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00075390-RA	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
Medex_00060377-RA	5	Reactome: R-HSA-73772;Reactome: R-HSA-427413;Reactome: R-HSA-5250924;Reactome: R-HSA-73863;Reactome: R-HSA-73762	"RNA Polymerase I Promoter Escape";"NoRC negatively regulates rRNA expression";"B-WICH complex positively regulates rRNA expression";"RNA Polymerase I Transcription Termination";"RNA Polymerase I Transcription Initiation"
Medex_00100138-RA	4	Reactome: R-HSA-68962;Reactome: R-HSA-176974;Reactome: R-HSA-69205;Reactome: R-HSA-176187	"Activation of the pre-replicative complex";"Unwinding of DNA";"G1/S-Specific Transcription";"Activation of ATR in response to replication stress"
Medex_00060400-RA	13	Reactome: R-HSA-72764;Reactome: R-HSA-72689;Reactome: R-HSA-975956;Reactome: R-HSA-72706;Reactome: R-HSA-6791226;Reactome: R-HSA-2408557;Reactome: R-HSA-192823;Reactome: R-HSA-975957;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-156902;Reactome: R-HSA-1799339	"Eukaryotic Translation Termination";"Formation of a pool of free 40S subunits";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Major pathway of rRNA processing in the nucleolus and cytosol";"Selenocysteine synthesis";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Peptide chain elongation";"SRP-dependent cotranslational protein targeting to membrane"
Medex_00061782-RA	6	MetaCyc: PWY-7039;Reactome: R-HSA-114508;KEGG: 00561+2.7.1.107;KEGG: 04070+2.7.1.107;MetaCyc: PWY-7817;KEGG: 00564+2.7.1.107	"Phosphatidate metabolism, as a signaling molecule";"Effects of PIP2 hydrolysis";"Glycerolipid metabolism";"Phosphatidylinositol signaling system";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Glycerophospholipid metabolism"
Medex_00057247-RA	13	Reactome: R-HSA-2022857;KEGG: 00511+3.2.1.52;KEGG: 00513+3.2.1.52;MetaCyc: PWY-7822;Reactome: R-HSA-2024101;KEGG: 00604+3.2.1.52;Reactome: R-HSA-1660662;MetaCyc: PWY-7883;MetaCyc: PWY-6902;KEGG: 00603+3.2.1.52;KEGG: 00531+3.2.1.52;KEGG: 00520+3.2.1.52;Reactome: R-HSA-2160916	"Keratan sulfate degradation";"Other glycan degradation";"Various types of N-glycan biosynthesis";"Chitin degradation III (Serratia)";"CS/DS degradation";"Glycosphingolipid biosynthesis - ganglio series";"Glycosphingolipid metabolism";"Anhydromuropeptides recycling II";"Chitin degradation II (Vibrio)";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Glycosaminoglycan degradation";"Amino sugar and nucleotide sugar metabolism";"Hyaluronan uptake and degradation"
Medex_00015579-RA	2	Reactome: R-HSA-909733;Reactome: R-HSA-8983711	"Interferon alpha/beta signaling";"OAS antiviral response"
Medex_00055773-RA	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
Medex_00092148-RA	2	Reactome: R-HSA-3371599;Reactome: R-HSA-196780	"Defective HLCS causes multiple carboxylase deficiency";"Biotin transport and metabolism"
Medex_00098886-RA	1	Reactome: R-HSA-390648	"Muscarinic acetylcholine receptors"
Medex_00070186-RA	1	Reactome: R-HSA-2470946	"Cohesin Loading onto Chromatin"
Medex_00077097-RA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
Medex_00069322-RA	3	Reactome: R-HSA-76061;Reactome: R-HSA-76066;Reactome: R-HSA-749476	"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Abortive And Retractive Initiation"
Medex_00083514-RA	7	Reactome: R-HSA-8854518;Reactome: R-HSA-380320;Reactome: R-HSA-380270;Reactome: R-HSA-380259;Reactome: R-HSA-2565942;Reactome: R-HSA-380284;Reactome: R-HSA-5620912	"AURKA Activation by TPX2";"Recruitment of NuMA to mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes";"Loss of Nlp from mitotic centrosomes";"Regulation of PLK1 Activity at G2/M Transition";"Loss of proteins required for interphase microtubule organization from the centrosome";"Anchoring of the basal body to the plasma membrane"
Medex_00050717-RA	4	KEGG: 00520+3.2.1.14;MetaCyc: PWY-7822;MetaCyc: PWY-6855;MetaCyc: PWY-6902	"Amino sugar and nucleotide sugar metabolism";"Chitin degradation III (Serratia)";"Chitin degradation I (archaea)";"Chitin degradation II (Vibrio)"
Medex_00054986-RA	1	Reactome: R-HSA-1237044	"Erythrocytes take up carbon dioxide and release oxygen"
Medex_00012210-RA	57	Reactome: R-HSA-174113;Reactome: R-HSA-4641257;Reactome: R-HSA-350562;Reactome: R-HSA-69481;Reactome: R-HSA-5678895;Reactome: R-HSA-8948751;Reactome: R-HSA-9604323;Reactome: R-HSA-68827;Reactome: R-HSA-69017;Reactome: R-HSA-5362768;Reactome: R-HSA-69601;Reactome: R-HSA-1234176;Reactome: R-HSA-5676590;Reactome: R-HSA-5607764;Reactome: R-HSA-174184;Reactome: R-HSA-1169091;Reactome: R-HSA-174154;Reactome: R-HSA-8951664;Reactome: R-HSA-2871837;Reactome: R-HSA-187577;Reactome: R-HSA-174084;Reactome: R-HSA-1236974;Reactome: R-HSA-8854050;Reactome: R-HSA-5610783;Reactome: R-HSA-195253;Reactome: R-HSA-8939902;Reactome: R-HSA-75815;Reactome: R-HSA-5689603;Reactome: R-HSA-5668541;Reactome: R-HSA-5687128;Reactome: R-HSA-4608870;Reactome: R-HSA-5610785;Reactome: R-HSA-5689880;Reactome: R-HSA-1236978;Reactome: R-HSA-349425;Reactome: R-HSA-180534;Reactome: R-HSA-5632684;Reactome: R-HSA-174178;Reactome: R-HSA-5607761;Reactome: R-HSA-8852276;Reactome: R-HSA-5610780;Reactome: R-HSA-983168;Reactome: R-HSA-202424;Reactome: R-HSA-5658442;Reactome: R-HSA-8941858;Reactome: R-HSA-5358346;Reactome: R-HSA-6798695;Reactome: R-HSA-9020702;Reactome: R-HSA-180585;Reactome: R-HSA-450408;Reactome: R-HSA-4641258;Reactome: R-HSA-2467813;Reactome: R-HSA-9010553;Reactome: R-HSA-382556;Reactome: R-HSA-68949;Reactome: R-HSA-211733;Reactome: R-HSA-8939236	"SCF-beta-TrCP mediated degradation of Emi1";"Degradation of AXIN";"Regulation of ornithine decarboxylase (ODC)";"G2/M Checkpoints";"Defective CFTR causes cystic fibrosis";"Regulation of PTEN stability and activity";"Negative regulation of NOTCH4 signaling";"CDT1 association with the CDC6:ORC:origin complex";"CDK-mediated phosphorylation and removal of Cdc6";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"NIK-->noncanonical NF-kB signaling";"CLEC7A (Dectin-1) signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Activation of NF-kappaB in B cells";"APC/C:Cdc20 mediated degradation of Securin";"Neddylation";"FCERI mediated NF-kB activation";"SCF(Skp2)-mediated degradation of p27/p21";"Autodegradation of Cdh1 by Cdh1:APC/C";"ER-Phagosome pathway";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Degradation of GLI2 by the proteasome";"Degradation of beta-catenin by the destruction complex";"Regulation of RUNX2 expression and activity";"Ubiquitin-dependent degradation of Cyclin D";"UCH proteinases";"TNFR2 non-canonical NF-kB pathway";"MAPK6/MAPK4 signaling";"Asymmetric localization of PCP proteins";"GLI3 is processed to GLI3R by the proteasome";"Ub-specific processing proteases";"Cross-presentation of soluble exogenous antigens (endosomes)";"Autodegradation of the E3 ubiquitin ligase COP1";"Vpu mediated degradation of CD4";"Hedgehog 'on' state";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Dectin-1 mediated noncanonical NF-kB signaling";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Degradation of GLI1 by the proteasome";"Antigen processing: Ubiquitination & Proteasome degradation";"Downstream TCR signaling";"Regulation of RAS by GAPs";"Regulation of RUNX3 expression and activity";"Hedgehog ligand biogenesis";"Neutrophil degranulation";"Interleukin-1 signaling";"Vif-mediated degradation of APOBEC3G";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Degradation of DVL";"Separation of Sister Chromatids";"Regulation of expression of SLITs and ROBOs";"ABC-family proteins mediated transport";"Orc1 removal from chromatin";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"RUNX1 regulates transcription of genes involved in differentiation of HSCs"
Medex_00008250-RA	2	Reactome: R-HSA-381340;Reactome: R-HSA-1989781	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression"
Medex_00057938-RA	3	Reactome: R-HSA-1660514;Reactome: R-HSA-1660517;Reactome: R-HSA-1660516	"Synthesis of PIPs at the Golgi membrane";"Synthesis of PIPs at the late endosome membrane";"Synthesis of PIPs at the early endosome membrane"
Medex_00097078-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Medex_00047478-RA	5	MetaCyc: PWY-6902;Reactome: R-HSA-189085;MetaCyc: PWY-6855;MetaCyc: PWY-7822;KEGG: 00520+3.2.1.14	"Chitin degradation II (Vibrio)";"Digestion of dietary carbohydrate";"Chitin degradation I (archaea)";"Chitin degradation III (Serratia)";"Amino sugar and nucleotide sugar metabolism"
Medex_00039591-RA	12	KEGG: 00720+4.1.3.25;KEGG: 00660+4.1.3.25;KEGG: 00620+2.3.3.9;MetaCyc: PWY-6969;KEGG: 00630+3.1.2.30+2.3.3.9;MetaCyc: PWY-6728;MetaCyc: PWY-7854;MetaCyc: PWY-5744;MetaCyc: PWY-7295;MetaCyc: PWY-7294;MetaCyc: PWY-5749;MetaCyc: PWY-7118	"Carbon fixation pathways in prokaryotes";"C5-Branched dibasic acid metabolism";"Pyruvate metabolism";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Glyoxylate and dicarboxylate metabolism";"Methylaspartate cycle";"Crotonyl-coa/ethylmalonyl-coa/hydroxybutyryl-coa cycle (engineered)";"Glyoxylate assimilation";"L-arabinose degradation IV";"D-xylose degradation IV";"Itaconate degradation";"Chitin degradation to ethanol"
Medex_00005129-RA	2	Reactome: R-HSA-9010553;Reactome: R-HSA-975957	"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
Medex_00006064-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Medex_00070558-RA	5	Reactome: R-HSA-1660662;Reactome: R-HSA-4085001;Reactome: R-HSA-4341670;Reactome: R-HSA-2132295;Reactome: R-HSA-6798695	"Glycosphingolipid metabolism";"Sialic acid metabolism";"Defective NEU1 causes sialidosis";"MHC class II antigen presentation";"Neutrophil degranulation"
Medex_00046449-RA	3	Reactome: R-HSA-6811438;Reactome: R-HSA-6811440;Reactome: R-HSA-6807878	"Intra-Golgi traffic";"Retrograde transport at the Trans-Golgi-Network";"COPI-mediated anterograde transport"
Medex_00071005-RA	7	Reactome: R-HSA-3108214;Reactome: R-HSA-1221632;Reactome: R-HSA-2468052;Reactome: R-HSA-2500257;Reactome: R-HSA-2467813;Reactome: R-HSA-2470946;Reactome: R-HSA-9018519	"SUMOylation of DNA damage response and repair proteins";"Meiotic synapsis";"Establishment of Sister Chromatid Cohesion";"Resolution of Sister Chromatid Cohesion";"Separation of Sister Chromatids";"Cohesin Loading onto Chromatin";"Estrogen-dependent gene expression"
Medex_00024522-RA	57	Reactome: R-HSA-195253;Reactome: R-HSA-75815;Reactome: R-HSA-8939902;Reactome: R-HSA-4608870;Reactome: R-HSA-5668541;Reactome: R-HSA-5689603;Reactome: R-HSA-5687128;Reactome: R-HSA-5610785;Reactome: R-HSA-5689880;Reactome: R-HSA-180534;Reactome: R-HSA-349425;Reactome: R-HSA-1236978;Reactome: R-HSA-5632684;Reactome: R-HSA-174178;Reactome: R-HSA-8852276;Reactome: R-HSA-5610780;Reactome: R-HSA-5607761;Reactome: R-HSA-202424;Reactome: R-HSA-983168;Reactome: R-HSA-5358346;Reactome: R-HSA-8941858;Reactome: R-HSA-5658442;Reactome: R-HSA-6798695;Reactome: R-HSA-9020702;Reactome: R-HSA-450408;Reactome: R-HSA-180585;Reactome: R-HSA-2467813;Reactome: R-HSA-4641258;Reactome: R-HSA-68949;Reactome: R-HSA-8939236;Reactome: R-HSA-382556;Reactome: R-HSA-211733;Reactome: R-HSA-9010553;Reactome: R-HSA-4641257;Reactome: R-HSA-174113;Reactome: R-HSA-69481;Reactome: R-HSA-5678895;Reactome: R-HSA-350562;Reactome: R-HSA-8948751;Reactome: R-HSA-9604323;Reactome: R-HSA-68827;Reactome: R-HSA-5676590;Reactome: R-HSA-5362768;Reactome: R-HSA-69017;Reactome: R-HSA-69601;Reactome: R-HSA-1234176;Reactome: R-HSA-5607764;Reactome: R-HSA-174184;Reactome: R-HSA-174154;Reactome: R-HSA-1169091;Reactome: R-HSA-2871837;Reactome: R-HSA-8951664;Reactome: R-HSA-174084;Reactome: R-HSA-187577;Reactome: R-HSA-8854050;Reactome: R-HSA-1236974;Reactome: R-HSA-5610783	"Degradation of beta-catenin by the destruction complex";"Ubiquitin-dependent degradation of Cyclin D";"Regulation of RUNX2 expression and activity";"Asymmetric localization of PCP proteins";"TNFR2 non-canonical NF-kB pathway";"UCH proteinases";"MAPK6/MAPK4 signaling";"GLI3 is processed to GLI3R by the proteasome";"Ub-specific processing proteases";"Vpu mediated degradation of CD4";"Autodegradation of the E3 ubiquitin ligase COP1";"Cross-presentation of soluble exogenous antigens (endosomes)";"Hedgehog 'on' state";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Degradation of GLI1 by the proteasome";"Dectin-1 mediated noncanonical NF-kB signaling";"Downstream TCR signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Hedgehog ligand biogenesis";"Regulation of RUNX3 expression and activity";"Regulation of RAS by GAPs";"Neutrophil degranulation";"Interleukin-1 signaling";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Vif-mediated degradation of APOBEC3G";"Separation of Sister Chromatids";"Degradation of DVL";"Orc1 removal from chromatin";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"ABC-family proteins mediated transport";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Regulation of expression of SLITs and ROBOs";"Degradation of AXIN";"SCF-beta-TrCP mediated degradation of Emi1";"G2/M Checkpoints";"Defective CFTR causes cystic fibrosis";"Regulation of ornithine decarboxylase (ODC)";"Regulation of PTEN stability and activity";"Negative regulation of NOTCH4 signaling";"CDT1 association with the CDC6:ORC:origin complex";"NIK-->noncanonical NF-kB signaling";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"CDK-mediated phosphorylation and removal of Cdc6";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"CLEC7A (Dectin-1) signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"APC/C:Cdc20 mediated degradation of Securin";"Activation of NF-kappaB in B cells";"FCERI mediated NF-kB activation";"Neddylation";"Autodegradation of Cdh1 by Cdh1:APC/C";"SCF(Skp2)-mediated degradation of p27/p21";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"ER-Phagosome pathway";"Degradation of GLI2 by the proteasome"
Medex_00036579-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Medex_00035465-RA	7	MetaCyc: PWY-6824;MetaCyc: PWY-5461;MetaCyc: PWY-5469;MetaCyc: PWY-7445;MetaCyc: PWY-7214;MetaCyc: PWY-5466;KEGG: 00940+1.11.1.7	"Justicidin B biosynthesis";"Betanidin degradation";"Sesamin biosynthesis";"Luteolin triglucuronide degradation";"Baicalein degradation (hydrogen peroxide detoxification)";"Matairesinol biosynthesis";"Phenylpropanoid biosynthesis"
Medex_00058416-RA	2	Reactome: R-HSA-5678895;Reactome: R-HSA-382556	"Defective CFTR causes cystic fibrosis";"ABC-family proteins mediated transport"
Medex_00103731-RA	2	Reactome: R-HSA-383280;Reactome: R-HSA-4090294	"Nuclear Receptor transcription pathway";"SUMOylation of intracellular receptors"
Medex_00092486-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00064424-RA	6	MetaCyc: PWY-7039;Reactome: R-HSA-114508;KEGG: 00561+2.7.1.107;KEGG: 04070+2.7.1.107;MetaCyc: PWY-7817;KEGG: 00564+2.7.1.107	"Phosphatidate metabolism, as a signaling molecule";"Effects of PIP2 hydrolysis";"Glycerolipid metabolism";"Phosphatidylinositol signaling system";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Glycerophospholipid metabolism"
Medex_00015973-RA	20	KEGG: 04151+2.7.11.1;Reactome: R-HSA-5218920;Reactome: R-HSA-5674400;Reactome: R-HSA-5628897;Reactome: R-HSA-389357;KEGG: 05163+2.7.11.1;Reactome: R-HSA-9639288;KEGG: 04150+2.7.11.1;Reactome: R-HSA-1257604;KEGG: 04714+2.7.11.1;Reactome: R-HSA-3371571;Reactome: R-HSA-8943724;KEGG: 04926+2.7.11.1;Reactome: R-HSA-6804757;Reactome: R-HSA-1632852;Reactome: R-HSA-165159;KEGG: 05170+2.7.11.1;Reactome: R-HSA-166208;KEGG: 05165+2.7.11.1;Reactome: R-HSA-380972	"PI3K-Akt signaling pathway";"VEGFR2 mediated vascular permeability";"Constitutive Signaling by AKT1 E17K in Cancer";"TP53 Regulates Metabolic Genes";"CD28 dependent PI3K/Akt signaling";"Human cytomegalovirus infection";"Amino acids regulate mTORC1";"mTOR signaling pathway";"PIP3 activates AKT signaling";"Thermogenesis";"HSF1-dependent transactivation";"Regulation of PTEN gene transcription";"Relaxin signaling pathway";"Regulation of TP53 Degradation";"Macroautophagy";"mTOR signalling";"Human immunodeficiency virus 1 infection";"mTORC1-mediated signalling";"Human papillomavirus infection";"Energy dependent regulation of mTOR by LKB1-AMPK"
Medex_00047411-RA	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
Medex_00083717-RA	2	KEGG: 00062+3.1.2.22;Reactome: R-HSA-75105	"Fatty acid elongation";"Fatty acyl-CoA biosynthesis"
Medex_00072808-RA	6	Reactome: R-HSA-6782135;Reactome: R-HSA-6781823;Reactome: R-HSA-6781827;Reactome: R-HSA-72163;MetaCyc: PWY-7511;Reactome: R-HSA-6782210	"Dual incision in TC-NER";"Formation of TC-NER Pre-Incision Complex";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"mRNA Splicing - Major Pathway";"Protein ubiquitination";"Gap-filling DNA repair synthesis and ligation in TC-NER"
Medex_00000361-RA	1	Reactome: R-HSA-3000178	"ECM proteoglycans"
Medex_00010538-RA	2	Reactome: R-HSA-8853383;KEGG: 00511+3.2.1.24	"Lysosomal oligosaccharide catabolism";"Other glycan degradation"
Medex_00008343-RA	2	Reactome: R-HSA-204005;Reactome: R-HSA-5694530	"COPII-mediated vesicle transport";"Cargo concentration in the ER"
Medex_00046218-RA	1	Reactome: R-HSA-70221	"Glycogen breakdown (glycogenolysis)"
Medex_00078784-RA	2	Reactome: R-HSA-5620924;Reactome: R-HSA-5610787	"Intraflagellar transport";"Hedgehog 'off' state"
Medex_00103531-RA	2	Reactome: R-HSA-5690338;Reactome: R-HSA-382556	"Defective ABCC6 causes pseudoxanthoma elasticum (PXE)";"ABC-family proteins mediated transport"
Medex_00013196-RA	6	Reactome: R-HSA-9640463;MetaCyc: PWY-5884;MetaCyc: PWY-7782;MetaCyc: PWY-6733;MetaCyc: PWY-7656;KEGG: 00073+1.2.1.84	"Wax biosynthesis";"Wax esters biosynthesis I";"Plasmalogen biosynthesis";"Sporopollenin precursors biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Cutin, suberine and wax biosynthesis"
Medex_00081995-RA	1	Reactome: R-HSA-2470946	"Cohesin Loading onto Chromatin"
Medex_00068709-RA	12	Reactome: R-HSA-6811436;Reactome: R-HSA-5620912;Reactome: R-HSA-6807878;Reactome: R-HSA-2132295;Reactome: R-HSA-2565942;Reactome: R-HSA-3371497;Reactome: R-HSA-380320;Reactome: R-HSA-8854518;Reactome: R-HSA-381038;Reactome: R-HSA-380284;Reactome: R-HSA-380259;Reactome: R-HSA-380270	"COPI-independent Golgi-to-ER retrograde traffic";"Anchoring of the basal body to the plasma membrane";"COPI-mediated anterograde transport";"MHC class II antigen presentation";"Regulation of PLK1 Activity at G2/M Transition";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Recruitment of NuMA to mitotic centrosomes";"AURKA Activation by TPX2";"XBP1(S) activates chaperone genes";"Loss of proteins required for interphase microtubule organization from the centrosome";"Loss of Nlp from mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes"
Medex_00019086-RA	16	Reactome: R-HSA-975957;Reactome: R-HSA-1799339;Reactome: R-HSA-9633012;Reactome: R-HSA-975956;Reactome: R-HSA-72706;Reactome: R-HSA-72764;Reactome: R-HSA-72702;Reactome: R-HSA-6791226;Reactome: R-HSA-192823;Reactome: R-HSA-72649;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-72695;Reactome: R-HSA-156902;Reactome: R-HSA-72689;Reactome: R-HSA-2408557	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Eukaryotic Translation Termination";"Ribosomal scanning and start codon recognition";"Major pathway of rRNA processing in the nucleolus and cytosol";"Viral mRNA Translation";"Translation initiation complex formation";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Formation of the ternary complex, and subsequently, the 43S complex";"Peptide chain elongation";"Formation of a pool of free 40S subunits";"Selenocysteine synthesis"
Medex_00060542-RA	1	KEGG: 00230+4.6.1.2	"Purine metabolism"
Medex_00002984-RA	3	Reactome: R-HSA-5678520;Reactome: R-HSA-159418;Reactome: R-HSA-193368	"Defective ABCB11 causes progressive familial intrahepatic cholestasis 2 and benign recurrent intrahepatic cholestasis 2";"Recycling of bile acids and salts";"Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol"
Medex_00091601-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00072230-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00052648-RA	1	Reactome: R-HSA-3108214	"SUMOylation of DNA damage response and repair proteins"
Medex_00095583-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Medex_00012569-RA	3	MetaCyc: PWY-6348;KEGG: 00730+3.1.3.2;KEGG: 00740+3.1.3.2	"Phosphate acquisition";"Thiamine metabolism";"Riboflavin metabolism"
Medex_00006485-RA	1	KEGG: 00480+3.4.11.2	"Glutathione metabolism"
Medex_00022999-RA	2	Reactome: R-HSA-445095;Reactome: R-HSA-6807878	"Interaction between L1 and Ankyrins";"COPI-mediated anterograde transport"
Medex_00008471-RA	5	Reactome: R-HSA-209560;Reactome: R-HSA-5205685;Reactome: R-HSA-205043;Reactome: R-HSA-9020702;Reactome: R-HSA-209543	"NF-kB is activated and signals survival";"Pink/Parkin Mediated Mitophagy";"NRIF signals cell death from the nucleus";"Interleukin-1 signaling";"p75NTR recruits signalling complexes"
Medex_00084670-RA	1	Reactome: R-HSA-163560	"Triglyceride catabolism"
Medex_00003313-RA	14	MetaCyc: PWY-5972;MetaCyc: PWY-7035;Reactome: R-HSA-75876;MetaCyc: PWY-6433;MetaCyc: PWY-7619;MetaCyc: PWY-7602;MetaCyc: PWY-7036;MetaCyc: PWY-7725;MetaCyc: PWY-6598;KEGG: 00062+2.3.1.199;MetaCyc: PWY-8041;MetaCyc: PWY-5080;MetaCyc: PWY-7724;MetaCyc: PWY-7601	"Stearate biosynthesis I (animals)";"(9Z)-tricosene biosynthesis";"Synthesis of very long-chain fatty acyl-CoAs";"Hydroxylated fatty acid biosynthesis (plants)";"Juniperonate biosynthesis";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis II";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Sciadonate biosynthesis";"Fatty acid elongation";"Ultra-long-chain fatty acid biosynthesis";"Very long chain fatty acid biosynthesis I";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)"
Medex_00095753-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Medex_00015630-RA	2	Reactome: R-HSA-3299685;KEGG: 00480+1.11.1.15	"Detoxification of Reactive Oxygen Species";"Glutathione metabolism"
Medex_00061017-RA	2	Reactome: R-HSA-381038;Reactome: R-HSA-1799339	"XBP1(S) activates chaperone genes";"SRP-dependent cotranslational protein targeting to membrane"
Medex_00084235-RA	1	Reactome: R-HSA-6782861	"Synthesis of wybutosine at G37 of tRNA(Phe)"
Medex_00004392-RA	3	Reactome: R-HSA-418359;Reactome: R-HSA-5578775;Reactome: R-HSA-936837	"Reduction of cytosolic Ca++ levels";"Ion homeostasis";"Ion transport by P-type ATPases"
Medex_00071932-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00030481-RA	1	Reactome: R-HSA-400253	"Circadian Clock"
Medex_00018419-RA	1	Reactome: R-HSA-110320	"Translesion Synthesis by POLH"
Medex_00093732-RA	2	KEGG: 00760+6.3.1.5;Reactome: R-HSA-196807	"Nicotinate and nicotinamide metabolism";"Nicotinate metabolism"
Medex_00085905-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00062624-RA	1	KEGG: 00480+3.4.11.1	"Glutathione metabolism"
Medex_00008562-RA	2	Reactome: R-HSA-418890;Reactome: R-HSA-3295583	"Role of second messengers in netrin-1 signaling";"TRP channels"
Medex_00016262-RA	2	Reactome: R-HSA-6803205;Reactome: R-HSA-8873719	"TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain";"RAB geranylgeranylation"
Medex_00047656-RA	40	KEGG: 00627+4.2.1.17;KEGG: 00280+4.2.1.17+1.1.1.35;MetaCyc: PWY-7606;MetaCyc: PWY-7779;KEGG: 00623+1.1.1.35;MetaCyc: PWY-6946;KEGG: 00071+4.2.1.17+1.1.1.35;MetaCyc: PWY-5177;KEGG: 00380+4.2.1.17+1.1.1.35;KEGG: 00903+4.2.1.17;MetaCyc: PWY-6945;MetaCyc: PWY-6883;KEGG: 00062+4.2.1.17+1.1.1.35;KEGG: 00360+4.2.1.17;MetaCyc: PWY-7726;KEGG: 00310+4.2.1.17+1.1.1.35;MetaCyc: PWY-5136;MetaCyc: PWY-7778;MetaCyc: PWY-7654;MetaCyc: PWY-7094;MetaCyc: PWY-6863;KEGG: 00362+4.2.1.17+1.1.1.35;MetaCyc: PWY-5138;KEGG: 00410+4.2.1.17;KEGG: 00592+4.2.1.17;MetaCyc: PWY-1361;MetaCyc: PWY-7401;MetaCyc: PWY-6944;MetaCyc: PWY-5789;KEGG: 00281+4.2.1.17+1.1.1.35;MetaCyc: PWY-5109;KEGG: 00720+4.2.1.17+1.1.1.35;MetaCyc: PWY-6583;MetaCyc: PWY-7656;KEGG: 00640+4.2.1.17;KEGG: 00650+4.2.1.17+1.1.1.35;MetaCyc: PWY-7216;KEGG: 00930+4.2.1.17+1.1.1.35;MetaCyc: PWY-6435;MetaCyc: PWY-7007	"Aminobenzoate degradation";"Valine, leucine and isoleucine degradation";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Methyl tert-butyl ether degradation";"Toluene degradation";"Cholesterol degradation to androstenedione II (cholesterol dehydrogenase)";"Fatty acid degradation";"Glutaryl-coa degradation";"Tryptophan metabolism";"Limonene and pinene degradation";"Cholesterol degradation to androstenedione I (cholesterol oxidase)";"Pyruvate fermentation to butanol II (engineered)";"Fatty acid elongation";"Phenylalanine metabolism";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"Lysine degradation";"Fatty acid beta-oxidation II (plant peroxisome)";"2-methylpropene degradation";"(8E,10E)-dodeca-8,10-dienol biosynthesis";"Fatty acid salvage";"Pyruvate fermentation to hexanol (engineered)";"Benzoate degradation";"Fatty acid beta-oxidation IV (unsaturated, even number)";"beta-Alanine metabolism";"alpha-Linolenic acid metabolism";"Benzoyl-coa degradation I (aerobic)";"Crotonate fermentation (to acetate and cyclohexane carboxylate)";"Androstenedione degradation";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Geraniol degradation";"Fermentation to 2-methylbutanoate";"Carbon fixation pathways in prokaryotes";"Pyruvate fermentation to butanol I";"Spodoptera littoralis pheromone biosynthesis";"Propanoate metabolism";"Butanoate metabolism";"(R)- and (S)-3-hydroxybutanoate biosynthesis (engineered)";"Caprolactam degradation";"4-hydroxybenzoate biosynthesis III (plants)";"Methyl ketone biosynthesis (engineered)"
Medex_00089853-RA	1	KEGG: 00240+3.1.3.89	"Pyrimidine metabolism"
Medex_00078940-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Medex_00000426-RA	3	Reactome: R-HSA-5362798;Reactome: R-HSA-381426;Reactome: R-HSA-8957275	"Release of Hh-Np from the secreting cell";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"Post-translational protein phosphorylation"
Medex_00030661-RA	13	Reactome: R-HSA-1799339;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-156902;Reactome: R-HSA-975957;Reactome: R-HSA-192823;Reactome: R-HSA-2408557;Reactome: R-HSA-6791226;Reactome: R-HSA-975956;Reactome: R-HSA-72706;Reactome: R-HSA-72689;Reactome: R-HSA-72764	"SRP-dependent cotranslational protein targeting to membrane";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Viral mRNA Translation";"Selenocysteine synthesis";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Formation of a pool of free 40S subunits";"Eukaryotic Translation Termination"
Medex_00075721-RA	3	MetaCyc: PWY-7158;MetaCyc: PWY-8099;KEGG: 00790+4.2.1.96	"L-phenylalanine degradation V";"Tetrahydropteridine recycling";"Folate biosynthesis"
Medex_00022228-RA	1	Reactome: R-HSA-1660661	"Sphingolipid de novo biosynthesis"
Medex_00053753-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00049568-RA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00056318-RA	1	Reactome: R-HSA-1474228	"Degradation of the extracellular matrix"
Medex_00062908-RA	3	KEGG: 00730+3.1.3.2;KEGG: 00740+3.1.3.2;MetaCyc: PWY-6348	"Thiamine metabolism";"Riboflavin metabolism";"Phosphate acquisition"
Medex_00067533-RA	3	MetaCyc: PWY-7999;KEGG: 00130+1.17.4.4;Reactome: R-HSA-6806664	"Vitamin K-epoxide cycle";"Ubiquinone and other terpenoid-quinone biosynthesis";"Metabolism of vitamin K"
Medex_00054635-RA	12	Reactome: R-HSA-1251985;Reactome: R-HSA-1442490;Reactome: R-HSA-982772;Reactome: R-HSA-2894862;Reactome: R-HSA-2122948;Reactome: R-HSA-75893;Reactome: R-HSA-5362798;Reactome: R-HSA-2691232;Reactome: R-HSA-177929;Reactome: R-HSA-193692;Reactome: R-HSA-2644606;Reactome: R-HSA-2660826	"Nuclear signaling by ERBB4";"Collagen degradation";"Growth hormone receptor signaling";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Activated NOTCH1 Transmits Signal to the Nucleus";"TNF signaling";"Release of Hh-Np from the secreting cell";"Constitutive Signaling by NOTCH1 HD Domain Mutants";"Signaling by EGFR";"Regulated proteolysis of p75NTR";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant"
Medex_00068344-RA	1	KEGG: 00970+6.1.1.16	"Aminoacyl-tRNA biosynthesis"
Medex_00074290-RA	7	KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1	"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Human cytomegalovirus infection";"Relaxin signaling pathway";"Thermogenesis"
Medex_00031296-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Medex_00075883-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Medex_00086260-RA	3	MetaCyc: PWY-4361;Reactome: R-HSA-1237112;KEGG: 00270+1.13.11.54	"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I";"Methionine salvage pathway";"Cysteine and methionine metabolism"
Medex_00047336-RA	2	Reactome: R-HSA-5682910;Reactome: R-HSA-5250971	"LGI-ADAM interactions";"Toxicity of botulinum toxin type C (BoNT/C)"
Medex_00056804-RA	11	Reactome: R-HSA-167287;Reactome: R-HSA-167243;Reactome: R-HSA-674695;Reactome: R-HSA-167152;Reactome: R-HSA-167290;Reactome: R-HSA-167200;Reactome: R-HSA-167246;Reactome: R-HSA-112382;Reactome: R-HSA-75955;Reactome: R-HSA-6796648;Reactome: R-HSA-167238	"HIV elongation arrest and recovery";"Tat-mediated HIV elongation arrest and recovery";"RNA Polymerase II Pre-transcription Events";"Formation of HIV elongation complex in the absence of HIV Tat";"Pausing and recovery of HIV elongation";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Tat-mediated elongation of the HIV-1 transcript";"Formation of RNA Pol II elongation complex";"RNA Polymerase II Transcription Elongation";"TP53 Regulates Transcription of DNA Repair Genes";"Pausing and recovery of Tat-mediated HIV elongation"
Medex_00006052-RA	2	Reactome: R-HSA-8939243;Reactome: R-HSA-8953750	"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"Transcriptional Regulation by E2F6"
Medex_00074880-RA	1	Reactome: R-HSA-429947	"Deadenylation of mRNA"
Medex_00080992-RA	2	MetaCyc: PWY-5386;KEGG: 00620+3.1.2.6	"Methylglyoxal degradation I";"Pyruvate metabolism"
Medex_00064015-RA	2	MetaCyc: PWY-6854;Reactome: R-HSA-3299685	"Ethylene biosynthesis III (microbes)";"Detoxification of Reactive Oxygen Species"
Medex_00102034-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Medex_00012798-RA	4	MetaCyc: PWY-6972;Reactome: R-HSA-5679001;Reactome: R-HSA-382556;Reactome: R-HSA-189483	"Oleandomycin activation/inactivation";"Defective ABCC2 causes Dubin-Johnson syndrome";"ABC-family proteins mediated transport";"Heme degradation"
Medex_00061481-RA	6	MetaCyc: PWY-7656;MetaCyc: PWY-7782;MetaCyc: PWY-6733;KEGG: 00073+1.2.1.84;Reactome: R-HSA-9640463;MetaCyc: PWY-5884	"Spodoptera littoralis pheromone biosynthesis";"Plasmalogen biosynthesis";"Sporopollenin precursors biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax biosynthesis";"Wax esters biosynthesis I"
Medex_00101638-RA	1	Reactome: R-HSA-6798163	"Choline catabolism"
Medex_00030352-RA	2	KEGG: 00670+2.1.2.9;KEGG: 00970+2.1.2.9	"One carbon pool by folate";"Aminoacyl-tRNA biosynthesis"
Medex_00050850-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00040038-RA	1	Reactome: R-HSA-8950505	"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"
Medex_00046372-RA	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
Medex_00078972-RA	6	Reactome: R-HSA-9010553;Reactome: R-HSA-159236;Reactome: R-HSA-72163;Reactome: R-HSA-72187;Reactome: R-HSA-975957;Reactome: R-HSA-73856	"Regulation of expression of SLITs and ROBOs";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"mRNA Splicing - Major Pathway";"mRNA 3'-end processing";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"RNA Polymerase II Transcription Termination"
Medex_00039503-RA	3	Reactome: R-HSA-5689880;Reactome: R-HSA-201722;Reactome: R-HSA-3214847	"Ub-specific processing proteases";"Formation of the beta-catenin:TCF transactivating complex";"HATs acetylate histones"
Medex_00088151-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Medex_00050072-RA	10	Reactome: R-HSA-5685942;Reactome: R-HSA-5685938;Reactome: R-HSA-5693607;Reactome: R-HSA-5693616;Reactome: R-HSA-5693554;Reactome: R-HSA-912446;Reactome: R-HSA-6804756;Reactome: R-HSA-5693579;Reactome: R-HSA-69473;Reactome: R-HSA-5693568	"HDR through Homologous Recombination (HRR)";"HDR through Single Strand Annealing (SSA)";"Processing of DNA double-strand break ends";"Presynaptic phase of homologous DNA pairing and strand exchange";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Meiotic recombination";"Regulation of TP53 Activity through Phosphorylation";"Homologous DNA Pairing and Strand Exchange";"G2/M DNA damage checkpoint";"Resolution of D-loop Structures through Holliday Junction Intermediates"
Medex_00061899-RA	6	KEGG: 00073+1.2.1.84;MetaCyc: PWY-6733;MetaCyc: PWY-7782;MetaCyc: PWY-7656;Reactome: R-HSA-9640463;MetaCyc: PWY-5884	"Cutin, suberine and wax biosynthesis";"Sporopollenin precursors biosynthesis";"Plasmalogen biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Wax biosynthesis";"Wax esters biosynthesis I"
Medex_00000073-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Medex_00103681-RA	3	KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16	"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation"
Medex_00071801-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Medex_00001764-RA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Medex_00064595-RA	4	MetaCyc: PWY-7193;KEGG: 00983+2.7.1.48;Reactome: R-HSA-73614;KEGG: 00240+2.7.1.48	"Pyrimidine ribonucleosides salvage I";"Drug metabolism - other enzymes";"Pyrimidine salvage";"Pyrimidine metabolism"
Medex_00001807-RA	2	Reactome: R-HSA-6785470;Reactome: R-HSA-6784531	"tRNA processing in the mitochondrion";"tRNA processing in the nucleus"
Medex_00075827-RA	7	Reactome: R-HSA-2500257;Reactome: R-HSA-1221632;Reactome: R-HSA-2468052;Reactome: R-HSA-3108214;Reactome: R-HSA-9018519;Reactome: R-HSA-2470946;Reactome: R-HSA-2467813	"Resolution of Sister Chromatid Cohesion";"Meiotic synapsis";"Establishment of Sister Chromatid Cohesion";"SUMOylation of DNA damage response and repair proteins";"Estrogen-dependent gene expression";"Cohesin Loading onto Chromatin";"Separation of Sister Chromatids"
Medex_00045930-RA	6	MetaCyc: PWY-6731;MetaCyc: PWY-7238;Reactome: R-HSA-70221;MetaCyc: PWY-6737;MetaCyc: PWY-5941;KEGG: 00500+2.4.1.1	"Starch degradation III";"Sucrose biosynthesis II";"Glycogen breakdown (glycogenolysis)";"Starch degradation V";"Glycogen degradation II";"Starch and sucrose metabolism"
Medex_00001167-RA	2	Reactome: R-HSA-6783310;Reactome: R-HSA-983168	"Fanconi Anemia Pathway";"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00042640-RA	2	Reactome: R-HSA-2022854;Reactome: R-HSA-975577	"Keratan sulfate biosynthesis";"N-Glycan antennae elongation"
Medex_00101028-RA	1	Reactome: R-HSA-6811434	"COPI-dependent Golgi-to-ER retrograde traffic"
Medex_00086532-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00036109-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Medex_00079861-RA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
Medex_00033470-RA	2	Reactome: R-HSA-5663213;Reactome: R-HSA-2029482	"RHO GTPases Activate WASPs and WAVEs";"Regulation of actin dynamics for phagocytic cup formation"
Medex_00024091-RA	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
Medex_00021128-RA	1	Reactome: R-HSA-159236	"Transport of Mature mRNA derived from an Intron-Containing Transcript"
Medex_00007340-RA	1	Reactome: R-HSA-6794361	"Neurexins and neuroligins"
Medex_00040278-RA	6	MetaCyc: PWY-7817;KEGG: 04070+2.7.1.107;KEGG: 00561+2.7.1.107;KEGG: 00564+2.7.1.107;MetaCyc: PWY-7039;Reactome: R-HSA-114508	"Type I lipoteichoic acid biosynthesis (S. aureus)";"Phosphatidylinositol signaling system";"Glycerolipid metabolism";"Glycerophospholipid metabolism";"Phosphatidate metabolism, as a signaling molecule";"Effects of PIP2 hydrolysis"
Medex_00005601-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00072398-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00010933-RA	10	KEGG: 04151+2.7.11.1;Reactome: R-HSA-5655302;Reactome: R-HSA-194840;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04714+2.7.11.1;Reactome: R-HSA-1839117	"PI3K-Akt signaling pathway";"Signaling by FGFR1 in disease";"Rho GTPase cycle";"Relaxin signaling pathway";"Human cytomegalovirus infection";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"Human papillomavirus infection";"Thermogenesis";"Signaling by cytosolic FGFR1 fusion mutants"
Medex_00004137-RA	2	Reactome: R-HSA-446199;Reactome: R-HSA-4755609	"Synthesis of Dolichyl-phosphate";"Defective DHDDS causes retinitis pigmentosa 59"
Medex_00054993-RA	2	Reactome: R-HSA-390471;Reactome: R-HSA-1660662	"Association of TriC/CCT with target proteins during biosynthesis";"Glycosphingolipid metabolism"
Medex_00062623-RA	1	KEGG: 00970+6.1.1.16	"Aminoacyl-tRNA biosynthesis"
Medex_00087639-RA	3	Reactome: R-HSA-6807878;Reactome: R-HSA-6811440;Reactome: R-HSA-6811438	"COPI-mediated anterograde transport";"Retrograde transport at the Trans-Golgi-Network";"Intra-Golgi traffic"
Medex_00035934-RA	3	Reactome: R-HSA-76071;Reactome: R-HSA-749476;Reactome: R-HSA-6807505	"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Abortive And Retractive Initiation";"RNA polymerase II transcribes snRNA genes"
Medex_00024526-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Medex_00080328-RA	1	Reactome: R-HSA-6784531	"tRNA processing in the nucleus"
Medex_00031687-RA	6	Reactome: R-HSA-176187;Reactome: R-HSA-176974;Reactome: R-HSA-68962;Reactome: R-HSA-68867;Reactome: R-HSA-68949;Reactome: R-HSA-69052	"Activation of ATR in response to replication stress";"Unwinding of DNA";"Activation of the pre-replicative complex";"Assembly of the pre-replicative complex";"Orc1 removal from chromatin";"Switching of origins to a post-replicative state"
Medex_00058707-RA	6	MetaCyc: PWY-5884;Reactome: R-HSA-9640463;MetaCyc: PWY-7782;MetaCyc: PWY-6733;MetaCyc: PWY-7656;KEGG: 00073+1.2.1.84	"Wax esters biosynthesis I";"Wax biosynthesis";"Plasmalogen biosynthesis";"Sporopollenin precursors biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Cutin, suberine and wax biosynthesis"
Medex_00023221-RA	4	Reactome: R-HSA-446193;KEGG: 00513+2.4.1.131;KEGG: 00510+2.4.1.131;Reactome: R-HSA-4551295	"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"Various types of N-glycan biosynthesis";"N-Glycan biosynthesis";"Defective ALG11 causes ALG11-CDG (CDG-1p)"
Medex_00006912-RA	2	Reactome: R-HSA-6811434;Reactome: R-HSA-6807878	"COPI-dependent Golgi-to-ER retrograde traffic";"COPI-mediated anterograde transport"
Medex_00035711-RA	40	KEGG: 00062+4.2.1.17+1.1.1.35;KEGG: 00360+4.2.1.17;KEGG: 00310+4.2.1.17+1.1.1.35;MetaCyc: PWY-7726;MetaCyc: PWY-6863;MetaCyc: PWY-7094;MetaCyc: PWY-7654;MetaCyc: PWY-7778;MetaCyc: PWY-5136;MetaCyc: PWY-7606;KEGG: 00280+4.2.1.17+1.1.1.35;KEGG: 00627+4.2.1.17;MetaCyc: PWY-5177;MetaCyc: PWY-6946;KEGG: 00623+1.1.1.35;KEGG: 00071+4.2.1.17+1.1.1.35;MetaCyc: PWY-7779;KEGG: 00903+4.2.1.17;KEGG: 00380+4.2.1.17+1.1.1.35;MetaCyc: PWY-6945;MetaCyc: PWY-6883;KEGG: 00650+4.2.1.17+1.1.1.35;KEGG: 00640+4.2.1.17;MetaCyc: PWY-7656;MetaCyc: PWY-7007;MetaCyc: PWY-6435;KEGG: 00930+4.2.1.17+1.1.1.35;MetaCyc: PWY-7216;KEGG: 00362+4.2.1.17+1.1.1.35;MetaCyc: PWY-6944;MetaCyc: PWY-7401;KEGG: 00592+4.2.1.17;MetaCyc: PWY-1361;KEGG: 00410+4.2.1.17;MetaCyc: PWY-5138;MetaCyc: PWY-5789;MetaCyc: PWY-6583;KEGG: 00720+4.2.1.17+1.1.1.35;MetaCyc: PWY-5109;KEGG: 00281+4.2.1.17+1.1.1.35	"Fatty acid elongation";"Phenylalanine metabolism";"Lysine degradation";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"Pyruvate fermentation to hexanol (engineered)";"Fatty acid salvage";"(8E,10E)-dodeca-8,10-dienol biosynthesis";"2-methylpropene degradation";"Fatty acid beta-oxidation II (plant peroxisome)";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Valine, leucine and isoleucine degradation";"Aminobenzoate degradation";"Glutaryl-coa degradation";"Cholesterol degradation to androstenedione II (cholesterol dehydrogenase)";"Toluene degradation";"Fatty acid degradation";"Methyl tert-butyl ether degradation";"Limonene and pinene degradation";"Tryptophan metabolism";"Cholesterol degradation to androstenedione I (cholesterol oxidase)";"Pyruvate fermentation to butanol II (engineered)";"Butanoate metabolism";"Propanoate metabolism";"Spodoptera littoralis pheromone biosynthesis";"Methyl ketone biosynthesis (engineered)";"4-hydroxybenzoate biosynthesis III (plants)";"Caprolactam degradation";"(R)- and (S)-3-hydroxybutanoate biosynthesis (engineered)";"Benzoate degradation";"Androstenedione degradation";"Crotonate fermentation (to acetate and cyclohexane carboxylate)";"alpha-Linolenic acid metabolism";"Benzoyl-coa degradation I (aerobic)";"beta-Alanine metabolism";"Fatty acid beta-oxidation IV (unsaturated, even number)";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Pyruvate fermentation to butanol I";"Carbon fixation pathways in prokaryotes";"Fermentation to 2-methylbutanoate";"Geraniol degradation"
Medex_00064875-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Medex_00023790-RA	1	Reactome: R-HSA-9633012	"Response of EIF2AK4 (GCN2) to amino acid deficiency"
Medex_00008934-RA	4	Reactome: R-HSA-1655829;Reactome: R-HSA-8874211;Reactome: R-HSA-381033;Reactome: R-HSA-8963889	"Regulation of cholesterol biosynthesis by SREBP (SREBF)";"CREB3 factors activate genes";"ATF6 (ATF6-alpha) activates chaperones";"Assembly of active LPL and LIPC lipase complexes"
Medex_00068960-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00056476-RA	3	Reactome: R-HSA-70350;KEGG: 00051+2.7.1.3;Reactome: R-HSA-5657562	"Fructose catabolism";"Fructose and mannose metabolism";"Essential fructosuria"
Medex_00035925-RA	1	Reactome: R-HSA-6798163	"Choline catabolism"
Medex_00042194-RA	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
Medex_00042641-RA	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
Medex_00035782-RA	9	Reactome: R-HSA-9639288;Reactome: R-HSA-165159;Reactome: R-HSA-1632852;Reactome: R-HSA-166208;Reactome: R-HSA-380972;Reactome: R-HSA-6798695;Reactome: R-HSA-8943724;Reactome: R-HSA-5674135;Reactome: R-HSA-5628897	"Amino acids regulate mTORC1";"mTOR signalling";"Macroautophagy";"mTORC1-mediated signalling";"Energy dependent regulation of mTOR by LKB1-AMPK";"Neutrophil degranulation";"Regulation of PTEN gene transcription";"MAP2K and MAPK activation";"TP53 Regulates Metabolic Genes"
Medex_00022670-RA	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276	"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination"
Medex_00020476-RA	8	KEGG: 00515+2.4.1.109;MetaCyc: PWY-7921;MetaCyc: PWY-7979;KEGG: 00514+2.4.1.109;Reactome: R-HSA-5173105;Reactome: R-HSA-5083629;MetaCyc: PWY-7922;Reactome: R-HSA-5083633	"Mannose type O-glycan biosynthesis";"Protein O-mannosylation I (yeast)";"Protein O-mannosylation III (mammals, core M3)";"Other types of O-glycan biosynthesis";"O-linked glycosylation";"Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2";"Protein O-mannosylation II (mammals, core M1 and core M2)";"Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1"
Medex_00035720-RA	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
Medex_00043902-RA	5	MetaCyc: PWY-3341;MetaCyc: PWY-6344;KEGG: 00330+1.5.1.2;Reactome: R-HSA-8964539;MetaCyc: PWY-4981	"L-proline biosynthesis III (from L-ornithine)";"L-ornithine degradation II (Stickland reaction)";"Arginine and proline metabolism";"Glutamate and glutamine metabolism";"L-proline biosynthesis II (from arginine)"
Medex_00086039-RA	24	Reactome: R-HSA-983189;Reactome: R-HSA-9609736;Reactome: R-HSA-8852276;Reactome: R-HSA-6807878;Reactome: R-HSA-190840;Reactome: R-HSA-437239;Reactome: R-HSA-190861;Reactome: R-HSA-9619483;Reactome: R-HSA-9609690;Reactome: R-HSA-6811436;Reactome: R-HSA-8955332;Reactome: R-HSA-5626467;Reactome: R-HSA-2132295;Reactome: R-HSA-2467813;Reactome: R-HSA-5617833;Reactome: R-HSA-9646399;Reactome: R-HSA-68877;Reactome: R-HSA-9648025;Reactome: R-HSA-6811434;Reactome: R-HSA-5663220;Reactome: R-HSA-1445148;Reactome: R-HSA-2500257;Reactome: R-HSA-380320;Reactome: R-HSA-3371497	"Kinesins";"Assembly and cell surface presentation of NMDA receptors";"The role of GTSE1 in G2/M progression after G2 checkpoint";"COPI-mediated anterograde transport";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Recycling pathway of L1";"Gap junction assembly";"Activation of AMPK downstream of NMDARs";"HCMV Early Events";"COPI-independent Golgi-to-ER retrograde traffic";"Carboxyterminal post-translational modifications of tubulin";"RHO GTPases activate IQGAPs";"MHC class II antigen presentation";"Separation of Sister Chromatids";"Cilium Assembly";"Aggrephagy";"Mitotic Prometaphase";"EML4 and NUDC in mitotic spindle formation";"COPI-dependent Golgi-to-ER retrograde traffic";"RHO GTPases Activate Formins";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Resolution of Sister Chromatid Cohesion";"Recruitment of NuMA to mitotic centrosomes";"HSP90 chaperone cycle for steroid hormone receptors (SHR)"
Medex_00037412-RA	1	Reactome: R-HSA-1474151	"Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation"
Medex_00011313-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Medex_00081308-RA	6	KEGG: 00052+2.7.7.12;Reactome: R-HSA-5609978;MetaCyc: PWY-6527;MetaCyc: PWY-6317;KEGG: 00520+2.7.7.12;Reactome: R-HSA-70370	"Galactose metabolism";"Defective GALT can cause Galactosemia";"Stachyose degradation";"D-galactose degradation I (Leloir pathway)";"Amino sugar and nucleotide sugar metabolism";"Galactose catabolism"
Medex_00045482-RA	1	Reactome: R-HSA-8866654	"E3 ubiquitin ligases ubiquitinate target proteins"
Medex_00094219-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Medex_00018015-RA	2	Reactome: R-HSA-164843;Reactome: R-HSA-5693571	"2-LTR circle formation";"Nonhomologous End-Joining (NHEJ)"
Medex_00003514-RA	2	KEGG: 00051+2.7.1.105+3.1.3.46;Reactome: R-HSA-9634600	"Fructose and mannose metabolism";"Regulation of glycolysis by fructose 2,6-bisphosphate metabolism"
Medex_00037724-RA	3	MetaCyc: PWY-6348;KEGG: 00730+3.1.3.2;KEGG: 00740+3.1.3.2	"Phosphate acquisition";"Thiamine metabolism";"Riboflavin metabolism"
Medex_00028793-RA	5	Reactome: R-HSA-933541;Reactome: R-HSA-936964;Reactome: R-HSA-9013973;Reactome: R-HSA-936440;Reactome: R-HSA-918233	"TRAF6 mediated IRF7 activation";"Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon";"TICAM1-dependent activation of IRF3/IRF7";"Negative regulators of DDX58/IFIH1 signaling";"TRAF3-dependent IRF activation pathway"
Medex_00020188-RA	2	Reactome: R-HSA-3214858;Reactome: R-HSA-8939243	"RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"
Medex_00004125-RA	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
Medex_00088279-RA	2	Reactome: R-HSA-1660662;Reactome: R-HSA-390471	"Glycosphingolipid metabolism";"Association of TriC/CCT with target proteins during biosynthesis"
Medex_00015610-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Medex_00089706-RA	2	Reactome: R-HSA-1660662;Reactome: R-HSA-390471	"Glycosphingolipid metabolism";"Association of TriC/CCT with target proteins during biosynthesis"
Medex_00064872-RA	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
Medex_00057442-RA	1	Reactome: R-HSA-1660661	"Sphingolipid de novo biosynthesis"
Medex_00027036-RA	56	Reactome: R-HSA-202424;Reactome: R-HSA-983168;Reactome: R-HSA-5358346;Reactome: R-HSA-8941858;Reactome: R-HSA-5658442;Reactome: R-HSA-9020702;Reactome: R-HSA-450408;Reactome: R-HSA-180585;Reactome: R-HSA-2467813;Reactome: R-HSA-4641258;Reactome: R-HSA-382556;Reactome: R-HSA-68949;Reactome: R-HSA-8939236;Reactome: R-HSA-211733;Reactome: R-HSA-9010553;Reactome: R-HSA-195253;Reactome: R-HSA-75815;Reactome: R-HSA-8939902;Reactome: R-HSA-4608870;Reactome: R-HSA-5689603;Reactome: R-HSA-5668541;Reactome: R-HSA-5687128;Reactome: R-HSA-5689880;Reactome: R-HSA-5610785;Reactome: R-HSA-180534;Reactome: R-HSA-1236978;Reactome: R-HSA-349425;Reactome: R-HSA-5632684;Reactome: R-HSA-174178;Reactome: R-HSA-8852276;Reactome: R-HSA-5610780;Reactome: R-HSA-5607761;Reactome: R-HSA-174084;Reactome: R-HSA-187577;Reactome: R-HSA-8854050;Reactome: R-HSA-1236974;Reactome: R-HSA-5610783;Reactome: R-HSA-4641257;Reactome: R-HSA-174113;Reactome: R-HSA-350562;Reactome: R-HSA-5678895;Reactome: R-HSA-69481;Reactome: R-HSA-9604323;Reactome: R-HSA-8948751;Reactome: R-HSA-68827;Reactome: R-HSA-5676590;Reactome: R-HSA-69601;Reactome: R-HSA-5362768;Reactome: R-HSA-69017;Reactome: R-HSA-1234176;Reactome: R-HSA-174184;Reactome: R-HSA-5607764;Reactome: R-HSA-174154;Reactome: R-HSA-1169091;Reactome: R-HSA-2871837;Reactome: R-HSA-8951664	"Downstream TCR signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Hedgehog ligand biogenesis";"Regulation of RUNX3 expression and activity";"Regulation of RAS by GAPs";"Interleukin-1 signaling";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Vif-mediated degradation of APOBEC3G";"Separation of Sister Chromatids";"Degradation of DVL";"ABC-family proteins mediated transport";"Orc1 removal from chromatin";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Regulation of expression of SLITs and ROBOs";"Degradation of beta-catenin by the destruction complex";"Ubiquitin-dependent degradation of Cyclin D";"Regulation of RUNX2 expression and activity";"Asymmetric localization of PCP proteins";"UCH proteinases";"TNFR2 non-canonical NF-kB pathway";"MAPK6/MAPK4 signaling";"Ub-specific processing proteases";"GLI3 is processed to GLI3R by the proteasome";"Vpu mediated degradation of CD4";"Cross-presentation of soluble exogenous antigens (endosomes)";"Autodegradation of the E3 ubiquitin ligase COP1";"Hedgehog 'on' state";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Degradation of GLI1 by the proteasome";"Dectin-1 mediated noncanonical NF-kB signaling";"Autodegradation of Cdh1 by Cdh1:APC/C";"SCF(Skp2)-mediated degradation of p27/p21";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"ER-Phagosome pathway";"Degradation of GLI2 by the proteasome";"Degradation of AXIN";"SCF-beta-TrCP mediated degradation of Emi1";"Regulation of ornithine decarboxylase (ODC)";"Defective CFTR causes cystic fibrosis";"G2/M Checkpoints";"Negative regulation of NOTCH4 signaling";"Regulation of PTEN stability and activity";"CDT1 association with the CDC6:ORC:origin complex";"NIK-->noncanonical NF-kB signaling";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"CDK-mediated phosphorylation and removal of Cdc6";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"CLEC7A (Dectin-1) signaling";"APC/C:Cdc20 mediated degradation of Securin";"Activation of NF-kappaB in B cells";"FCERI mediated NF-kB activation";"Neddylation"
Medex_00047095-RA	4	Reactome: R-HSA-8856828;Reactome: R-HSA-2029482;Reactome: R-HSA-3928662;Reactome: R-HSA-5663213	"Clathrin-mediated endocytosis";"Regulation of actin dynamics for phagocytic cup formation";"EPHB-mediated forward signaling";"RHO GTPases Activate WASPs and WAVEs"
Medex_00082719-RA	1	Reactome: R-HSA-2132295	"MHC class II antigen presentation"
Medex_00002302-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Medex_00069244-RA	10	Reactome: R-HSA-196757;MetaCyc: PWY-2201;MetaCyc: PWY-5497;KEGG: 00670+1.5.1.5+3.5.4.9;MetaCyc: PWY-7909;MetaCyc: PWY-6613;MetaCyc: PWY-3841;MetaCyc: PWY-1722;KEGG: 00720+1.5.1.5+3.5.4.9;MetaCyc: PWY-5030	"Metabolism of folate and pterines";"Folate transformations I";"Purine nucleobases degradation II (anaerobic)";"One carbon pool by folate";"Formaldehyde oxidation VII (THF pathway)";"Tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate";"Folate transformations II (plants)";"Formate assimilation into 5,10-methylenetetrahydrofolate";"Carbon fixation pathways in prokaryotes";"L-histidine degradation III"
Medex_00091220-RA	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
Medex_00049617-RA	5	Reactome: R-HSA-6798695;Reactome: R-HSA-8856828;Reactome: R-HSA-8856825;Reactome: R-HSA-6811440;Reactome: R-HSA-432722	"Neutrophil degranulation";"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis";"Retrograde transport at the Trans-Golgi-Network";"Golgi Associated Vesicle Biogenesis"
Medex_00069974-RA	2	Reactome: R-HSA-1369062;Reactome: R-HSA-9603798	"ABC transporters in lipid homeostasis";"Class I peroxisomal membrane protein import"
Medex_00038346-RA	1	Reactome: R-HSA-163560	"Triglyceride catabolism"
Medex_00072596-RA	2	Reactome: R-HSA-2151201;Reactome: R-HSA-1989781	"Transcriptional activation of mitochondrial biogenesis";"PPARA activates gene expression"
Medex_00011413-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Medex_00041297-RA	3	Reactome: R-HSA-6811440;Reactome: R-HSA-6807878;Reactome: R-HSA-6811438	"Retrograde transport at the Trans-Golgi-Network";"COPI-mediated anterograde transport";"Intra-Golgi traffic"
Medex_00065245-RA	5	Reactome: R-HSA-6782210;Reactome: R-HSA-6781827;Reactome: R-HSA-72163;Reactome: R-HSA-6782135;Reactome: R-HSA-6781823	"Gap-filling DNA repair synthesis and ligation in TC-NER";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"mRNA Splicing - Major Pathway";"Dual incision in TC-NER";"Formation of TC-NER Pre-Incision Complex"
Medex_00044727-RA	3	Reactome: R-HSA-4420097;Reactome: R-HSA-2029482;Reactome: R-HSA-5663213	"VEGFA-VEGFR2 Pathway";"Regulation of actin dynamics for phagocytic cup formation";"RHO GTPases Activate WASPs and WAVEs"
Medex_00083274-RA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
Medex_00006349-RA	1	Reactome: R-HSA-6784531	"tRNA processing in the nucleus"
Medex_00003317-RA	14	MetaCyc: PWY-8041;MetaCyc: PWY-5080;KEGG: 00062+2.3.1.199;MetaCyc: PWY-6598;MetaCyc: PWY-7725;MetaCyc: PWY-7724;MetaCyc: PWY-7601;MetaCyc: PWY-7035;MetaCyc: PWY-5972;Reactome: R-HSA-75876;MetaCyc: PWY-7036;MetaCyc: PWY-7619;MetaCyc: PWY-7602;MetaCyc: PWY-6433	"Ultra-long-chain fatty acid biosynthesis";"Very long chain fatty acid biosynthesis I";"Fatty acid elongation";"Sciadonate biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"(9Z)-tricosene biosynthesis";"Stearate biosynthesis I (animals)";"Synthesis of very long-chain fatty acyl-CoAs";"Very long chain fatty acid biosynthesis II";"Juniperonate biosynthesis";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Hydroxylated fatty acid biosynthesis (plants)"
Medex_00004794-RA	5	KEGG: 00730+2.7.4.3;KEGG: 00230+2.7.4.3;MetaCyc: PWY-7219;Reactome: R-HSA-499943;KEGG: 00230+2.7.4.10	"Thiamine metabolism";"Purine metabolism";"Adenosine ribonucleotides de novo biosynthesis";"Interconversion of nucleotide di- and triphosphates";"Purine metabolism"
Medex_00034984-RA	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
Medex_00031123-RA	6	Reactome: R-HSA-917977;Reactome: R-HSA-77387;Reactome: R-HSA-983712;Reactome: R-HSA-1222556;Reactome: R-HSA-9639288;Reactome: R-HSA-6798695	"Transferrin endocytosis and recycling";"Insulin receptor recycling";"Ion channel transport";"ROS and RNS production in phagocytes";"Amino acids regulate mTORC1";"Neutrophil degranulation"
Medex_00041061-RA	1	MetaCyc: PWY-7437	"Protein O-[N-acetyl]-glucosylation"
Medex_00088992-RA	1	Reactome: R-HSA-2393930	"Phosphate bond hydrolysis by NUDT proteins"
Medex_00023293-RA	11	Reactome: R-HSA-5358565;Reactome: R-HSA-69473;Reactome: R-HSA-5693579;Reactome: R-HSA-6804756;Reactome: R-HSA-5693568;Reactome: R-HSA-5358606;Reactome: R-HSA-5693607;Reactome: R-HSA-5685938;Reactome: R-HSA-5685942;Reactome: R-HSA-5693554;Reactome: R-HSA-5693616	"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"G2/M DNA damage checkpoint";"Homologous DNA Pairing and Strand Exchange";"Regulation of TP53 Activity through Phosphorylation";"Resolution of D-loop Structures through Holliday Junction Intermediates";"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"Processing of DNA double-strand break ends";"HDR through Single Strand Annealing (SSA)";"HDR through Homologous Recombination (HRR)";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Presynaptic phase of homologous DNA pairing and strand exchange"
Medex_00053135-RA	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
Medex_00080283-RA	7	KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1	"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Human papillomavirus infection";"Relaxin signaling pathway";"Thermogenesis";"Human cytomegalovirus infection"
Medex_00066694-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Medex_00048403-RA	2	Reactome: R-HSA-70921;KEGG: 00340+2.1.1.22	"Histidine catabolism";"Histidine metabolism"
Medex_00000494-RA	2	Reactome: R-HSA-1660662;Reactome: R-HSA-390471	"Glycosphingolipid metabolism";"Association of TriC/CCT with target proteins during biosynthesis"
Medex_00021788-RA	1	Reactome: R-HSA-3299685	"Detoxification of Reactive Oxygen Species"
Medex_00026680-RA	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
Medex_00001872-RA	2	Reactome: R-HSA-5620924;Reactome: R-HSA-5610787	"Intraflagellar transport";"Hedgehog 'off' state"
Medex_00072873-RA	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
Medex_00025998-RA	3	Reactome: R-HSA-110357;Reactome: R-HSA-110329;Reactome: R-HSA-110328	"Displacement of DNA glycosylase by APEX1";"Cleavage of the damaged pyrimidine";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine"
Medex_00073190-RA	8	Reactome: R-HSA-182218;Reactome: R-HSA-167590;Reactome: R-HSA-917977;Reactome: R-HSA-1222556;Reactome: R-HSA-9636467;Reactome: R-HSA-9639288;Reactome: R-HSA-77387;Reactome: R-HSA-983712	"Nef Mediated CD8 Down-regulation";"Nef Mediated CD4 Down-regulation";"Transferrin endocytosis and recycling";"ROS and RNS production in phagocytes";"Blockage of phagosome acidification";"Amino acids regulate mTORC1";"Insulin receptor recycling";"Ion channel transport"
Medex_00091854-RA	1	Reactome: R-HSA-2142789	"Ubiquinol biosynthesis"
Medex_00004395-RA	3	Reactome: R-HSA-418359;Reactome: R-HSA-936837;Reactome: R-HSA-5578775	"Reduction of cytosolic Ca++ levels";"Ion transport by P-type ATPases";"Ion homeostasis"
Medex_00030716-RA	6	Reactome: R-HSA-5693607;Reactome: R-HSA-69473;Reactome: R-HSA-6804756;Reactome: R-HSA-5685938;Reactome: R-HSA-5693616;Reactome: R-HSA-176187	"Processing of DNA double-strand break ends";"G2/M DNA damage checkpoint";"Regulation of TP53 Activity through Phosphorylation";"HDR through Single Strand Annealing (SSA)";"Presynaptic phase of homologous DNA pairing and strand exchange";"Activation of ATR in response to replication stress"
Medex_00006323-RA	1	Reactome: R-HSA-6790901	"rRNA modification in the nucleus and cytosol"
Medex_00058599-RA	6	Reactome: R-HSA-429958;Reactome: R-HSA-380994;Reactome: R-HSA-450604;Reactome: R-HSA-450385;Reactome: R-HSA-450513;Reactome: R-HSA-6791226	"mRNA decay by 3' to 5' exoribonuclease";"ATF4 activates genes in response to endoplasmic reticulum stress";"KSRP (KHSRP) binds and destabilizes mRNA";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"Major pathway of rRNA processing in the nucleolus and cytosol"
Medex_00015553-RA	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
Medex_00019029-RA	3	Reactome: R-HSA-2162123;KEGG: 00590+5.3.99.3;Reactome: R-HSA-6798695	"Synthesis of Prostaglandins (PG) and Thromboxanes (TX)";"Arachidonic acid metabolism";"Neutrophil degranulation"
Medex_00047132-RA	16	Reactome: R-HSA-5693571;Reactome: R-HSA-3214847;Reactome: R-HSA-201722;Reactome: R-HSA-5693548;Reactome: R-HSA-5693616;Reactome: R-HSA-5693554;Reactome: R-HSA-5685942;Reactome: R-HSA-2559586;Reactome: R-HSA-5693568;Reactome: R-HSA-5693565;Reactome: R-HSA-9018519;Reactome: R-HSA-69473;Reactome: R-HSA-6804756;Reactome: R-HSA-5693579;Reactome: R-HSA-5693607;Reactome: R-HSA-5685938	"Nonhomologous End-Joining (NHEJ)";"HATs acetylate histones";"Formation of the beta-catenin:TCF transactivating complex";"Sensing of DNA Double Strand Breaks";"Presynaptic phase of homologous DNA pairing and strand exchange";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"HDR through Homologous Recombination (HRR)";"DNA Damage/Telomere Stress Induced Senescence";"Resolution of D-loop Structures through Holliday Junction Intermediates";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Estrogen-dependent gene expression";"G2/M DNA damage checkpoint";"Regulation of TP53 Activity through Phosphorylation";"Homologous DNA Pairing and Strand Exchange";"Processing of DNA double-strand break ends";"HDR through Single Strand Annealing (SSA)"
Medex_00009278-RA	3	Reactome: R-HSA-446107;Reactome: R-HSA-264870;Reactome: R-HSA-2022090	"Type I hemidesmosome assembly";"Caspase-mediated cleavage of cytoskeletal proteins";"Assembly of collagen fibrils and other multimeric structures"
Medex_00005853-RA	4	MetaCyc: PWY-6902;MetaCyc: PWY-7822;MetaCyc: PWY-6855;KEGG: 00520+3.2.1.14	"Chitin degradation II (Vibrio)";"Chitin degradation III (Serratia)";"Chitin degradation I (archaea)";"Amino sugar and nucleotide sugar metabolism"
Medex_00062494-RA	2	Reactome: R-HSA-8983711;Reactome: R-HSA-909733	"OAS antiviral response";"Interferon alpha/beta signaling"
Medex_00046286-RA	6	KEGG: 00052+3.2.1.23;KEGG: 00531+3.2.1.23;KEGG: 00604+3.2.1.23;KEGG: 00600+3.2.1.23;KEGG: 00511+3.2.1.23;MetaCyc: PWY-6807	"Galactose metabolism";"Glycosaminoglycan degradation";"Glycosphingolipid biosynthesis - ganglio series";"Sphingolipid metabolism";"Other glycan degradation";"Xyloglucan degradation II (exoglucanase)"
Medex_00009813-RA	2	Reactome: R-HSA-429947;Reactome: R-HSA-6804115	"Deadenylation of mRNA";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"
Medex_00060991-RA	7	Reactome: R-HSA-9639288;Reactome: R-HSA-165159;Reactome: R-HSA-1632852;Reactome: R-HSA-166208;Reactome: R-HSA-8943724;Reactome: R-HSA-5628897;Reactome: R-HSA-380972	"Amino acids regulate mTORC1";"mTOR signalling";"Macroautophagy";"mTORC1-mediated signalling";"Regulation of PTEN gene transcription";"TP53 Regulates Metabolic Genes";"Energy dependent regulation of mTOR by LKB1-AMPK"
Medex_00098365-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00050711-RA	16	Reactome: R-HSA-72706;Reactome: R-HSA-975956;Reactome: R-HSA-72764;Reactome: R-HSA-72702;Reactome: R-HSA-6791226;Reactome: R-HSA-975957;Reactome: R-HSA-1799339;Reactome: R-HSA-9633012;Reactome: R-HSA-72689;Reactome: R-HSA-2408557;Reactome: R-HSA-192823;Reactome: R-HSA-72649;Reactome: R-HSA-72695;Reactome: R-HSA-156902;Reactome: R-HSA-9010553;Reactome: R-HSA-156827	"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Ribosomal scanning and start codon recognition";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Formation of a pool of free 40S subunits";"Selenocysteine synthesis";"Viral mRNA Translation";"Translation initiation complex formation";"Formation of the ternary complex, and subsequently, the 43S complex";"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression"
Medex_00059476-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Medex_00052068-RA	1	Reactome: R-HSA-975957	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
Medex_00008926-RA	29	Reactome: R-HSA-73776;Reactome: R-HSA-167152;Reactome: R-HSA-674695;Reactome: R-HSA-73863;Reactome: R-HSA-6781823;Reactome: R-HSA-73772;Reactome: R-HSA-167172;Reactome: R-HSA-6782210;Reactome: R-HSA-167246;Reactome: R-HSA-167160;Reactome: R-HSA-167200;Reactome: R-HSA-6782135;Reactome: R-HSA-76042;Reactome: R-HSA-75955;Reactome: R-HSA-167162;Reactome: R-HSA-73762;Reactome: R-HSA-113418;Reactome: R-HSA-5696395;Reactome: R-HSA-167158;Reactome: R-HSA-6781827;Reactome: R-HSA-75953;Reactome: R-HSA-167161;Reactome: R-HSA-77075;Reactome: R-HSA-427413;Reactome: R-HSA-6796648;Reactome: R-HSA-5696400;Reactome: R-HSA-73779;Reactome: R-HSA-72086;Reactome: R-HSA-112382	"RNA Polymerase II Promoter Escape";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase I Transcription Termination";"Formation of TC-NER Pre-Incision Complex";"RNA Polymerase I Promoter Escape";"Transcription of the HIV genome";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Tat-mediated elongation of the HIV-1 transcript";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Dual incision in TC-NER";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II Transcription Elongation";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase I Transcription Initiation";"Formation of the Early Elongation Complex";"Formation of Incision Complex in GG-NER";"Formation of the HIV-1 Early Elongation Complex";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"RNA Polymerase II Transcription Initiation";"HIV Transcription Initiation";"RNA Pol II CTD phosphorylation and interaction with CE";"NoRC negatively regulates rRNA expression";"TP53 Regulates Transcription of DNA Repair Genes";"Dual Incision in GG-NER";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"mRNA Capping";"Formation of RNA Pol II elongation complex"
Medex_00003243-RA	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
Medex_00030480-RA	1	Reactome: R-HSA-400253	"Circadian Clock"
Medex_00060120-RA	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
Medex_00035670-RA	7	KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1	"Human cytomegalovirus infection";"Thermogenesis";"Relaxin signaling pathway";"Human papillomavirus infection";"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection"
Medex_00041363-RA	1	Reactome: R-HSA-70171	"Glycolysis"
Medex_00028548-RA	3	Reactome: R-HSA-6798695;KEGG: 00511+3.2.1.51;MetaCyc: PWY-6807	"Neutrophil degranulation";"Other glycan degradation";"Xyloglucan degradation II (exoglucanase)"
Medex_00003798-RA	1	Reactome: R-HSA-1445148	"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
Medex_00070040-RA	2	Reactome: R-HSA-1268020;Reactome: R-HSA-71403	"Mitochondrial protein import";"Citric acid cycle (TCA cycle)"
Medex_00076868-RA	6	Reactome: R-HSA-429958;Reactome: R-HSA-380994;Reactome: R-HSA-450513;Reactome: R-HSA-450604;Reactome: R-HSA-450385;Reactome: R-HSA-6791226	"mRNA decay by 3' to 5' exoribonuclease";"ATF4 activates genes in response to endoplasmic reticulum stress";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"KSRP (KHSRP) binds and destabilizes mRNA";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"Major pathway of rRNA processing in the nucleolus and cytosol"
Medex_00019341-RA	2	KEGG: 00970+6.1.1.9;Reactome: R-HSA-379716	"Aminoacyl-tRNA biosynthesis";"Cytosolic tRNA aminoacylation"
Medex_00075486-RA	7	KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1	"Human cytomegalovirus infection";"Thermogenesis";"Relaxin signaling pathway";"Human papillomavirus infection";"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection"
Medex_00034056-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00062049-RA	2	Reactome: R-HSA-1296052;Reactome: R-HSA-418457	"Ca2+ activated K+ channels";"cGMP effects"
Medex_00066463-RA	3	Reactome: R-HSA-76061;Reactome: R-HSA-76066;Reactome: R-HSA-749476	"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Abortive And Retractive Initiation"
Medex_00077933-RA	1	Reactome: R-HSA-112308	"Presynaptic depolarization and calcium channel opening"
Medex_00033012-RA	8	KEGG: 04151+2.7.11.1;Reactome: R-HSA-6791226;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1	"PI3K-Akt signaling pathway";"Major pathway of rRNA processing in the nucleolus and cytosol";"Human cytomegalovirus infection";"Relaxin signaling pathway";"Human papillomavirus infection";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"Thermogenesis"
Medex_00069458-RA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00086534-RA	2	Reactome: R-HSA-8949613;Reactome: R-HSA-163210	"Cristae formation";"Formation of ATP by chemiosmotic coupling"
Medex_00102053-RA	16	Reactome: R-HSA-72702;Reactome: R-HSA-6791226;Reactome: R-HSA-72706;Reactome: R-HSA-975956;Reactome: R-HSA-72764;Reactome: R-HSA-1799339;Reactome: R-HSA-9633012;Reactome: R-HSA-975957;Reactome: R-HSA-2408557;Reactome: R-HSA-72689;Reactome: R-HSA-72649;Reactome: R-HSA-156902;Reactome: R-HSA-72695;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-192823	"Ribosomal scanning and start codon recognition";"Major pathway of rRNA processing in the nucleolus and cytosol";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"SRP-dependent cotranslational protein targeting to membrane";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Selenocysteine synthesis";"Formation of a pool of free 40S subunits";"Translation initiation complex formation";"Peptide chain elongation";"Formation of the ternary complex, and subsequently, the 43S complex";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Viral mRNA Translation"
Medex_00018146-RA	13	Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-9633012;Reactome: R-HSA-156902;Reactome: R-HSA-1799339;Reactome: R-HSA-192823;Reactome: R-HSA-975957;Reactome: R-HSA-6791226;Reactome: R-HSA-2408557;Reactome: R-HSA-72689;Reactome: R-HSA-72764;Reactome: R-HSA-975956;Reactome: R-HSA-72706	"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Peptide chain elongation";"SRP-dependent cotranslational protein targeting to membrane";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"Selenocysteine synthesis";"Formation of a pool of free 40S subunits";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit"
Medex_00025864-RA	1	Reactome: R-HSA-201681	"TCF dependent signaling in response to WNT"
Medex_00047625-RA	33	Reactome: R-HSA-2467813;Reactome: R-HSA-1169408;Reactome: R-HSA-168333;Reactome: R-HSA-159227;Reactome: R-HSA-159231;Reactome: R-HSA-9648025;Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-159230;Reactome: R-HSA-3232142;Reactome: R-HSA-168271;Reactome: R-HSA-170822;Reactome: R-HSA-4551638;Reactome: R-HSA-168325;Reactome: R-HSA-191859;Reactome: R-HSA-141444;Reactome: R-HSA-165054;Reactome: R-HSA-180746;Reactome: R-HSA-3371453;Reactome: R-HSA-4615885;Reactome: R-HSA-2500257;Reactome: R-HSA-168276;Reactome: R-HSA-5578749;Reactome: R-HSA-3301854;Reactome: R-HSA-180910;Reactome: R-HSA-4570464;Reactome: R-HSA-4085377;Reactome: R-HSA-9609690;Reactome: R-HSA-5619107;Reactome: R-HSA-9610379;Reactome: R-HSA-159236;Reactome: R-HSA-3108214;Reactome: R-HSA-6784531	"Separation of Sister Chromatids";"ISG15 antiviral mechanism";"NEP/NS2 Interacts with the Cellular Export Machinery";"Transport of the SLBP independent Mature mRNA";"Transport of Mature mRNA Derived from an Intronless Transcript";"EML4 and NUDC in mitotic spindle formation";"Mitotic Prometaphase";"RHO GTPases Activate Formins";"Transport of the SLBP Dependant Mature mRNA";"SUMOylation of ubiquitinylation proteins";"Transport of Ribonucleoproteins into the Host Nucleus";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"SUMOylation of chromatin organization proteins";"Viral Messenger RNA Synthesis";"snRNP Assembly";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Rev-mediated nuclear export of HIV RNA";"Nuclear import of Rev protein";"Regulation of HSF1-mediated heat shock response";"SUMOylation of DNA replication proteins";"Resolution of Sister Chromatid Cohesion";"NS1 Mediated Effects on Host Pathways";"Transcriptional regulation by small RNAs";"Nuclear Pore Complex (NPC) Disassembly";"Vpr-mediated nuclear import of PICs";"SUMOylation of RNA binding proteins";"SUMOylation of SUMOylation proteins";"HCMV Early Events";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"HCMV Late Events";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"SUMOylation of DNA damage response and repair proteins";"tRNA processing in the nucleus"
Medex_00071423-RA	6	Reactome: R-HSA-6791226;Reactome: R-HSA-429958;Reactome: R-HSA-380994;Reactome: R-HSA-450604;Reactome: R-HSA-450513;Reactome: R-HSA-450385	"Major pathway of rRNA processing in the nucleolus and cytosol";"mRNA decay by 3' to 5' exoribonuclease";"ATF4 activates genes in response to endoplasmic reticulum stress";"KSRP (KHSRP) binds and destabilizes mRNA";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA"
Medex_00083231-RA	2	Reactome: R-HSA-381038;Reactome: R-HSA-1799339	"XBP1(S) activates chaperone genes";"SRP-dependent cotranslational protein targeting to membrane"
Medex_00042675-RA	18	Reactome: R-HSA-3108214;Reactome: R-HSA-5693571;Reactome: R-HSA-6796648;Reactome: R-HSA-8953750;Reactome: R-HSA-5685942;Reactome: R-HSA-912446;Reactome: R-HSA-5693554;Reactome: R-HSA-5693616;Reactome: R-HSA-5693579;Reactome: R-HSA-6804756;Reactome: R-HSA-69473;Reactome: R-HSA-5693565;Reactome: R-HSA-5693568;Reactome: R-HSA-1221632;Reactome: R-HSA-5685938;Reactome: R-HSA-5693607;MetaCyc: PWY-7511;Reactome: R-HSA-5689901	"SUMOylation of DNA damage response and repair proteins";"Nonhomologous End-Joining (NHEJ)";"TP53 Regulates Transcription of DNA Repair Genes";"Transcriptional Regulation by E2F6";"HDR through Homologous Recombination (HRR)";"Meiotic recombination";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Presynaptic phase of homologous DNA pairing and strand exchange";"Homologous DNA Pairing and Strand Exchange";"Regulation of TP53 Activity through Phosphorylation";"G2/M DNA damage checkpoint";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Resolution of D-loop Structures through Holliday Junction Intermediates";"Meiotic synapsis";"HDR through Single Strand Annealing (SSA)";"Processing of DNA double-strand break ends";"Protein ubiquitination";"Metalloprotease DUBs"
Medex_00046044-RA	1	Reactome: R-HSA-425561	"Sodium/Calcium exchangers"
Medex_00008430-RA	1	Reactome: R-HSA-380320	"Recruitment of NuMA to mitotic centrosomes"
Medex_00083998-RA	3	Reactome: R-HSA-110328;Reactome: R-HSA-110329;Reactome: R-HSA-110357	"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"Cleavage of the damaged pyrimidine";"Displacement of DNA glycosylase by APEX1"
Medex_00000003-RA	24	Reactome: R-HSA-983189;Reactome: R-HSA-9609736;Reactome: R-HSA-8852276;Reactome: R-HSA-6807878;Reactome: R-HSA-437239;Reactome: R-HSA-190861;Reactome: R-HSA-9619483;Reactome: R-HSA-190840;Reactome: R-HSA-8955332;Reactome: R-HSA-6811436;Reactome: R-HSA-9609690;Reactome: R-HSA-5626467;Reactome: R-HSA-2132295;Reactome: R-HSA-2467813;Reactome: R-HSA-5617833;Reactome: R-HSA-9646399;Reactome: R-HSA-6811434;Reactome: R-HSA-9648025;Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-1445148;Reactome: R-HSA-380320;Reactome: R-HSA-2500257;Reactome: R-HSA-3371497	"Kinesins";"Assembly and cell surface presentation of NMDA receptors";"The role of GTSE1 in G2/M progression after G2 checkpoint";"COPI-mediated anterograde transport";"Recycling pathway of L1";"Gap junction assembly";"Activation of AMPK downstream of NMDARs";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Carboxyterminal post-translational modifications of tubulin";"COPI-independent Golgi-to-ER retrograde traffic";"HCMV Early Events";"RHO GTPases activate IQGAPs";"MHC class II antigen presentation";"Separation of Sister Chromatids";"Cilium Assembly";"Aggrephagy";"COPI-dependent Golgi-to-ER retrograde traffic";"EML4 and NUDC in mitotic spindle formation";"Mitotic Prometaphase";"RHO GTPases Activate Formins";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Recruitment of NuMA to mitotic centrosomes";"Resolution of Sister Chromatid Cohesion";"HSP90 chaperone cycle for steroid hormone receptors (SHR)"
Medex_00017424-RA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
Medex_00054515-RA	2	Reactome: R-HSA-6811434;Reactome: R-HSA-6807878	"COPI-dependent Golgi-to-ER retrograde traffic";"COPI-mediated anterograde transport"
Medex_00008249-RA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
Medex_00096029-RA	2	Reactome: R-HSA-8951664;Reactome: R-HSA-983168	"Neddylation";"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00103759-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00057144-RA	1	Reactome: R-HSA-425410	"Metal ion SLC transporters"
Medex_00011391-RA	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5419276;Reactome: R-HSA-5389840	"Mitochondrial translation initiation";"Mitochondrial translation termination";"Mitochondrial translation elongation"
Medex_00073717-RA	1	Reactome: R-HSA-8951664	"Neddylation"
Medex_00040977-RA	1	Reactome: R-HSA-6809371	"Formation of the cornified envelope"
Medex_00021158-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Medex_00075347-RA	1	Reactome: R-HSA-202733	"Cell surface interactions at the vascular wall"
Medex_00023948-RA	18	MetaCyc: PWY-6638;MetaCyc: PWY-7383;MetaCyc: PWY-7115;MetaCyc: PWY-6642;KEGG: 00270+2.6.1.1;KEGG: 00350+2.6.1.1;KEGG: 00360+2.6.1.1;KEGG: 00220+2.6.1.1;MetaCyc: PWY-5913;MetaCyc: PWY-6643;KEGG: 00710+2.6.1.1;MetaCyc: PWY-7117;KEGG: 00250+2.6.1.1;KEGG: 00950+2.6.1.1;KEGG: 00400+2.6.1.1;KEGG: 00401+2.6.1.1;KEGG: 00960+2.6.1.1;KEGG: 00330+2.6.1.1	"Sulfolactate degradation III";"Anaerobic energy metabolism (invertebrates, cytosol)";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"(R)-cysteate degradation";"Cysteine and methionine metabolism";"Tyrosine metabolism";"Phenylalanine metabolism";"Arginine biosynthesis";"Partial TCA cycle (obligate autotrophs)";"Coenzyme M biosynthesis II";"Carbon fixation in photosynthetic organisms";"C4 photosynthetic carbon assimilation cycle, PEPCK type";"Alanine, aspartate and glutamate metabolism";"Isoquinoline alkaloid biosynthesis";"Phenylalanine, tyrosine and tryptophan biosynthesis";"Novobiocin biosynthesis";"Tropane, piperidine and pyridine alkaloid biosynthesis";"Arginine and proline metabolism"
Medex_00000017-RA	5	Reactome: R-HSA-2132295;Reactome: R-HSA-6798695;Reactome: R-HSA-4341670;Reactome: R-HSA-1660662;Reactome: R-HSA-4085001	"MHC class II antigen presentation";"Neutrophil degranulation";"Defective NEU1 causes sialidosis";"Glycosphingolipid metabolism";"Sialic acid metabolism"
Medex_00017294-RA	6	KEGG: 00531+3.2.1.23;KEGG: 00052+3.2.1.23;MetaCyc: PWY-6807;KEGG: 00511+3.2.1.23;KEGG: 00600+3.2.1.23;KEGG: 00604+3.2.1.23	"Glycosaminoglycan degradation";"Galactose metabolism";"Xyloglucan degradation II (exoglucanase)";"Other glycan degradation";"Sphingolipid metabolism";"Glycosphingolipid biosynthesis - ganglio series"
Medex_00044620-RA	1	KEGG: 00290+4.2.1.33	"Valine, leucine and isoleucine biosynthesis"
Medex_00029628-RA	13	MetaCyc: PWY-7112;MetaCyc: PWY-6370;MetaCyc: PWY-4061;Reactome: R-HSA-156590;KEGG: 00053+1.8.5.1;MetaCyc: PWY-6842;KEGG: 00982+2.5.1.18;MetaCyc: PWY-7533;KEGG: 00983+2.5.1.18;MetaCyc: PWY-2261;KEGG: 00480+2.5.1.18+1.8.5.1;Reactome: R-HSA-196836;KEGG: 00980+2.5.1.18	"4-hydroxy-2-nonenal detoxification";"Ascorbate recycling (cytosolic)";"Glutathione-mediated detoxification I";"Glutathione conjugation";"Ascorbate and aldarate metabolism";"Glutathione-mediated detoxification II";"Drug metabolism - cytochrome P450";"Gliotoxin biosynthesis";"Drug metabolism - other enzymes";"Ascorbate glutathione cycle";"Glutathione metabolism";"Vitamin C (ascorbate) metabolism";"Metabolism of xenobiotics by cytochrome P450"
Medex_00080902-RA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Medex_00059024-RA	1	Reactome: R-HSA-389957	"Prefoldin mediated transfer of substrate to CCT/TriC"
Medex_00078503-RA	3	Reactome: R-HSA-76071;Reactome: R-HSA-749476;Reactome: R-HSA-6807505	"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Abortive And Retractive Initiation";"RNA polymerase II transcribes snRNA genes"
Medex_00016731-RA	14	MetaCyc: PWY-181;MetaCyc: PWY-5497;KEGG: 00260+2.1.2.1;MetaCyc: PWY-2201;MetaCyc: PWY-3661;KEGG: 00460+2.1.2.1;KEGG: 00630+2.1.2.1;MetaCyc: PWY-3661-1;Reactome: R-HSA-196757;MetaCyc: PWY-1622;KEGG: 00680+2.1.2.1;KEGG: 00670+2.1.2.1;MetaCyc: PWY-2161;MetaCyc: PWY-3841	"Photorespiration ";"Purine nucleobases degradation II (anaerobic)";"Glycine, serine and threonine metabolism";"Folate transformations I";"Glycine betaine degradation I";"Cyanoamino acid metabolism";"Glyoxylate and dicarboxylate metabolism";"Glycine betaine degradation II (mammalian)";"Metabolism of folate and pterines";"Formaldehyde assimilation I (serine pathway)";"Methane metabolism";"One carbon pool by folate";"Folate polyglutamylation";"Folate transformations II (plants)"
Medex_00087243-RA	7	KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1	"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Human papillomavirus infection";"Relaxin signaling pathway";"Thermogenesis";"Human cytomegalovirus infection"
Medex_00098186-RA	3	KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway"
Medex_00038180-RA	1	Reactome: R-HSA-400253	"Circadian Clock"
Medex_00064617-RA	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
Medex_00023356-RA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Medex_00021809-RA	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
Medex_00016723-RA	2	Reactome: R-HSA-5628897;Reactome: R-HSA-611105	"TP53 Regulates Metabolic Genes";"Respiratory electron transport"
Medex_00019764-RA	2	Reactome: R-HSA-8949613;Reactome: R-HSA-163210	"Cristae formation";"Formation of ATP by chemiosmotic coupling"
Medex_00008745-RA	2	Reactome: R-HSA-174403;Reactome: R-HSA-5578998	"Glutathione synthesis and recycling";"Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD)"
Medex_00050058-RA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00030489-RA	2	Reactome: R-HSA-3299685;KEGG: 00480+1.11.1.15	"Detoxification of Reactive Oxygen Species";"Glutathione metabolism"
Medex_00096705-RA	57	Reactome: R-HSA-2467813;Reactome: R-HSA-4641258;Reactome: R-HSA-450408;Reactome: R-HSA-180585;Reactome: R-HSA-382556;Reactome: R-HSA-68949;Reactome: R-HSA-8939236;Reactome: R-HSA-211733;Reactome: R-HSA-9010553;Reactome: R-HSA-5358346;Reactome: R-HSA-8941858;Reactome: R-HSA-5658442;Reactome: R-HSA-202424;Reactome: R-HSA-983168;Reactome: R-HSA-9020702;Reactome: R-HSA-6798695;Reactome: R-HSA-5632684;Reactome: R-HSA-180534;Reactome: R-HSA-349425;Reactome: R-HSA-1236978;Reactome: R-HSA-8852276;Reactome: R-HSA-5610780;Reactome: R-HSA-5607761;Reactome: R-HSA-174178;Reactome: R-HSA-75815;Reactome: R-HSA-8939902;Reactome: R-HSA-195253;Reactome: R-HSA-5689880;Reactome: R-HSA-5610785;Reactome: R-HSA-4608870;Reactome: R-HSA-5668541;Reactome: R-HSA-5687128;Reactome: R-HSA-5689603;Reactome: R-HSA-5610783;Reactome: R-HSA-8854050;Reactome: R-HSA-1236974;Reactome: R-HSA-174084;Reactome: R-HSA-187577;Reactome: R-HSA-174154;Reactome: R-HSA-1169091;Reactome: R-HSA-174184;Reactome: R-HSA-5607764;Reactome: R-HSA-2871837;Reactome: R-HSA-8951664;Reactome: R-HSA-69481;Reactome: R-HSA-5678895;Reactome: R-HSA-350562;Reactome: R-HSA-4641257;Reactome: R-HSA-174113;Reactome: R-HSA-5676590;Reactome: R-HSA-69601;Reactome: R-HSA-5362768;Reactome: R-HSA-1234176;Reactome: R-HSA-69017;Reactome: R-HSA-8948751;Reactome: R-HSA-68827;Reactome: R-HSA-9604323	"Separation of Sister Chromatids";"Degradation of DVL";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Vif-mediated degradation of APOBEC3G";"ABC-family proteins mediated transport";"Orc1 removal from chromatin";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Regulation of expression of SLITs and ROBOs";"Hedgehog ligand biogenesis";"Regulation of RUNX3 expression and activity";"Regulation of RAS by GAPs";"Downstream TCR signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Interleukin-1 signaling";"Neutrophil degranulation";"Hedgehog 'on' state";"Vpu mediated degradation of CD4";"Autodegradation of the E3 ubiquitin ligase COP1";"Cross-presentation of soluble exogenous antigens (endosomes)";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Degradation of GLI1 by the proteasome";"Dectin-1 mediated noncanonical NF-kB signaling";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Ubiquitin-dependent degradation of Cyclin D";"Regulation of RUNX2 expression and activity";"Degradation of beta-catenin by the destruction complex";"Ub-specific processing proteases";"GLI3 is processed to GLI3R by the proteasome";"Asymmetric localization of PCP proteins";"TNFR2 non-canonical NF-kB pathway";"MAPK6/MAPK4 signaling";"UCH proteinases";"Degradation of GLI2 by the proteasome";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"ER-Phagosome pathway";"Autodegradation of Cdh1 by Cdh1:APC/C";"SCF(Skp2)-mediated degradation of p27/p21";"APC/C:Cdc20 mediated degradation of Securin";"Activation of NF-kappaB in B cells";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"CLEC7A (Dectin-1) signaling";"FCERI mediated NF-kB activation";"Neddylation";"G2/M Checkpoints";"Defective CFTR causes cystic fibrosis";"Regulation of ornithine decarboxylase (ODC)";"Degradation of AXIN";"SCF-beta-TrCP mediated degradation of Emi1";"NIK-->noncanonical NF-kB signaling";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"CDK-mediated phosphorylation and removal of Cdc6";"Regulation of PTEN stability and activity";"CDT1 association with the CDC6:ORC:origin complex";"Negative regulation of NOTCH4 signaling"
Medex_00060554-RA	1	Reactome: R-HSA-193648	"NRAGE signals death through JNK"
Medex_00023876-RA	17	Reactome: R-HSA-5358565;Reactome: R-HSA-5656169;Reactome: R-HSA-69091;Reactome: R-HSA-110314;Reactome: R-HSA-5358606;Reactome: R-HSA-6782135;Reactome: R-HSA-69166;Reactome: R-HSA-6782210;Reactome: R-HSA-174417;Reactome: R-HSA-5651801;Reactome: R-HSA-174411;Reactome: R-HSA-69183;Reactome: R-HSA-174414;Reactome: R-HSA-5696400;Reactome: R-HSA-5696397;Reactome: R-HSA-5685942;Reactome: R-HSA-174437	"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"Termination of translesion DNA synthesis";"Polymerase switching";"Recognition of DNA damage by PCNA-containing replication complex";"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"Dual incision in TC-NER";"Removal of the Flap Intermediate";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Telomere C-strand (Lagging Strand) Synthesis";"PCNA-Dependent Long Patch Base Excision Repair";"Polymerase switching on the C-strand of the telomere";"Processive synthesis on the lagging strand";"Processive synthesis on the C-strand of the telomere";"Dual Incision in GG-NER";"Gap-filling DNA repair synthesis and ligation in GG-NER";"HDR through Homologous Recombination (HRR)";"Removal of the Flap Intermediate from the C-strand"
Medex_00005995-RA	13	Reactome: R-HSA-192823;Reactome: R-HSA-975957;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-156902;Reactome: R-HSA-9633012;Reactome: R-HSA-1799339;Reactome: R-HSA-72764;Reactome: R-HSA-72689;Reactome: R-HSA-975956;Reactome: R-HSA-72706;Reactome: R-HSA-6791226;Reactome: R-HSA-2408557	"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Peptide chain elongation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"SRP-dependent cotranslational protein targeting to membrane";"Eukaryotic Translation Termination";"Formation of a pool of free 40S subunits";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Major pathway of rRNA processing in the nucleolus and cytosol";"Selenocysteine synthesis"
Medex_00031760-RA	5	KEGG: 00760+2.7.1.23;MetaCyc: PWY-7269;Reactome: R-HSA-196807;MetaCyc: PWY-7268;MetaCyc: PWY-5083	"Nicotinate and nicotinamide metabolism";"NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)";"Nicotinate metabolism";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"NAD/NADH phosphorylation and dephosphorylation"
Medex_00054496-RA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
Medex_00000464-RA	2	Reactome: R-HSA-9033241;Reactome: R-HSA-389661	"Peroxisomal protein import";"Glyoxylate metabolism and glycine degradation"
Medex_00037708-RA	1	Reactome: R-HSA-8951664	"Neddylation"
Medex_00004640-RA	1	Reactome: R-HSA-2024096	"HS-GAG degradation"
Medex_00059350-RA	12	KEGG: 00130+2.5.1.39;MetaCyc: PWY-5873;MetaCyc: PWY-6708;MetaCyc: PWY-5857;MetaCyc: PWY-5871;MetaCyc: PWY-6978;Reactome: R-HSA-1268020;Reactome: R-HSA-2142789;MetaCyc: PWY-5856;MetaCyc: PWY-5855;MetaCyc: PWY-5870;MetaCyc: PWY-5872	"Ubiquinone and other terpenoid-quinone biosynthesis";"Ubiquinol-7 biosynthesis (eukaryotic)";"Ubiquinol-8 biosynthesis (prokaryotic)";"Ubiquinol-10 biosynthesis (prokaryotic)";"Ubiquinol-9 biosynthesis (eukaryotic)";"Plastoquinol-9 biosynthesis II";"Mitochondrial protein import";"Ubiquinol biosynthesis";"Ubiquinol-9 biosynthesis (prokaryotic)";"Ubiquinol-7 biosynthesis (prokaryotic)";"Ubiquinol-8 biosynthesis (eukaryotic)";"Ubiquinol-10 biosynthesis (eukaryotic)"
Medex_00072045-RA	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
Medex_00007893-RA	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
Medex_00070469-RA	9	Reactome: R-HSA-1855204;Reactome: R-HSA-416476;MetaCyc: PWY-6367;Reactome: R-HSA-112043;KEGG: 04070+3.1.4.11;KEGG: 00562+3.1.4.11;MetaCyc: PWY-7039;MetaCyc: PWY-6351;MetaCyc: PWY-8052	"Synthesis of IP3 and IP4 in the cytosol";"G alpha (q) signalling events";"D-myo-inositol-5-phosphate metabolism";"PLC beta mediated events";"Phosphatidylinositol signaling system";"Inositol phosphate metabolism";"Phosphatidate metabolism, as a signaling molecule";"D-myo-inositol (1,4,5)-trisphosphate biosynthesis";"2-arachidonoylglycerol biosynthesis"
Medex_00088991-RA	1	Reactome: R-HSA-6790901	"rRNA modification in the nucleus and cytosol"
Medex_00001748-RA	1	Reactome: R-HSA-6803157	"Antimicrobial peptides"
Medex_00022647-RA	14	KEGG: 00590+3.1.1.4;KEGG: 00565+3.1.1.4;Reactome: R-HSA-975634;MetaCyc: PWY-7416;MetaCyc: PWY-7409;MetaCyc: PWY-8051;MetaCyc: PWY-6803;KEGG: 00591+3.1.1.4;MetaCyc: PWY-7417;MetaCyc: PWY-8053;KEGG: 00592+3.1.1.4;KEGG: 00564+3.1.1.4+3.1.1.5;MetaCyc: PWY-7783;Reactome: R-HSA-1482788	"Arachidonic acid metabolism";"Ether lipid metabolism";"Retinoid metabolism and transport";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Anandamide biosynthesis I";"Phosphatidylcholine acyl editing";"Linoleic acid metabolism";"Phospholipid remodeling (phosphatidate, yeast)";"Anandamide biosynthesis II";"alpha-Linolenic acid metabolism";"Glycerophospholipid metabolism";"Plasmalogen degradation";"Acyl chain remodelling of PC"
Medex_00023590-RA	31	MetaCyc: PWY-5994;MetaCyc: PWY-8012;MetaCyc: PWY-5973;Reactome: R-HSA-163765;MetaCyc: PWY-7664;MetaCyc: PWY-7858;MetaCyc: PWY-5142;MetaCyc: PWY-5366;MetaCyc: PWYG-321;MetaCyc: PWY-5966-1;MetaCyc: PWY-6282;MetaCyc: PWY-7663;MetaCyc: PWY-7723;MetaCyc: PWY-5989;MetaCyc: PWY-8047;Reactome: R-HSA-199220;MetaCyc: PWY-7746;MetaCyc: PWY-6799;MetaCyc: PWY-8049;MetaCyc: PWY-5367;MetaCyc: PWY-5147;KEGG: 00780+1.1.1.100+4.2.1.59+2.3.1.41;Reactome: R-HSA-75105;MetaCyc: PWY-5971;Reactome: R-HSA-9029558;MetaCyc: PWY-6113;MetaCyc: PWY-7388;Reactome: R-HSA-2426168;MetaCyc: PWY-4381;MetaCyc: PWY-6519;KEGG: 00061+1.1.1.100+2.3.1.85+4.2.1.59+2.3.1.39+2.3.1.41+3.1.2.14	"Palmitate biosynthesis (animals and fungi, cytoplasm)";"Mupirocin biosynthesis";"Cis-vaccenate biosynthesis";"ChREBP activates metabolic gene expression";"Oleate biosynthesis IV (anaerobic)";"(5Z)-dodecenoate biosynthesis II";"Acyl-[acyl-carrier protein] thioesterase pathway";"Palmitoleate biosynthesis II (plants and bacteria)";"";"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)";"Palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate)";"Gondoate biosynthesis (anaerobic)";"Bacterial bioluminescence";"Stearate biosynthesis II (bacteria and plants)";"Bryostatin biosynthesis";"Vitamin B5 (pantothenate) metabolism";"Mycobacterial sulfolipid biosynthesis";"Fatty acid biosynthesis initiation (plant mitochondria)";"Pederin biosynthesis";"Petroselinate biosynthesis";"Oleate biosynthesis I (plants)";"Biotin metabolism";"Fatty acyl-CoA biosynthesis";"Palmitate biosynthesis II (bacteria and plant cytoplasm)";"NR1H2 & NR1H3 regulate gene expression linked to lipogenesis";"Superpathway of mycolate biosynthesis";"Octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast)";"Activation of gene expression by SREBF (SREBP)";"Fatty acid biosynthesis initiation (bacteria and plants)";"8-amino-7-oxononanoate biosynthesis I";"Fatty acid biosynthesis"
Medex_00006259-RA	2	Reactome: R-HSA-196780;Reactome: R-HSA-3371599	"Biotin transport and metabolism";"Defective HLCS causes multiple carboxylase deficiency"
Medex_00025107-RA	29	Reactome: R-HSA-5693565;KEGG: 05163+2.7.11.1;Reactome: R-HSA-6803204;Reactome: R-HSA-5693568;Reactome: R-HSA-2559586;Reactome: R-HSA-3371453;Reactome: R-HSA-69473;Reactome: R-HSA-5693579;KEGG: 04151+2.7.11.1;Reactome: R-HSA-6804756;Reactome: R-HSA-69541;Reactome: R-HSA-6803207;KEGG: 04714+2.7.11.1;Reactome: R-HSA-5693607;Reactome: R-HSA-6804760;KEGG: 04150+2.7.11.1;Reactome: R-HSA-5685938;Reactome: R-HSA-6796648;Reactome: R-HSA-6804757;Reactome: R-HSA-5693571;KEGG: 04926+2.7.11.1;Reactome: R-HSA-5693548;Reactome: R-HSA-5693554;Reactome: R-HSA-912446;Reactome: R-HSA-349425;Reactome: R-HSA-5693616;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;Reactome: R-HSA-5685942	"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Human cytomegalovirus infection";"TP53 Regulates Transcription of Genes Involved in Cytochrome C Release";"Resolution of D-loop Structures through Holliday Junction Intermediates";"DNA Damage/Telomere Stress Induced Senescence";"Regulation of HSF1-mediated heat shock response";"G2/M DNA damage checkpoint";"Homologous DNA Pairing and Strand Exchange";"PI3K-Akt signaling pathway";"Regulation of TP53 Activity through Phosphorylation";"Stabilization of p53";"TP53 Regulates Transcription of Caspase Activators and Caspases";"Thermogenesis";"Processing of DNA double-strand break ends";"Regulation of TP53 Activity through Methylation";"mTOR signaling pathway";"HDR through Single Strand Annealing (SSA)";"TP53 Regulates Transcription of DNA Repair Genes";"Regulation of TP53 Degradation";"Nonhomologous End-Joining (NHEJ)";"Relaxin signaling pathway";"Sensing of DNA Double Strand Breaks";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Meiotic recombination";"Autodegradation of the E3 ubiquitin ligase COP1";"Presynaptic phase of homologous DNA pairing and strand exchange";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"HDR through Homologous Recombination (HRR)"
Medex_00095345-RA	1	Reactome: R-HSA-430039	"mRNA decay by 5' to 3' exoribonuclease"
Medex_00022709-RA	1	Reactome: R-HSA-5389840	"Mitochondrial translation elongation"
Medex_00047725-RA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Medex_00103441-RA	1	Reactome: R-HSA-8951664	"Neddylation"
Medex_00090783-RA	3	Reactome: R-HSA-5678520;Reactome: R-HSA-159418;Reactome: R-HSA-193368	"Defective ABCB11 causes progressive familial intrahepatic cholestasis 2 and benign recurrent intrahepatic cholestasis 2";"Recycling of bile acids and salts";"Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol"
Medex_00007746-RA	11	Reactome: R-HSA-200425;MetaCyc: PWY-5966-1;Reactome: R-HSA-2426168;KEGG: 00061+6.4.1.2;MetaCyc: PWY-6679;KEGG: 00254+6.4.1.2;KEGG: 00720+6.4.1.2;Reactome: R-HSA-196780;KEGG: 00640+6.4.1.2;KEGG: 00620+6.4.1.2;Reactome: R-HSA-163765	"Carnitine metabolism";"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)";"Activation of gene expression by SREBF (SREBP)";"Fatty acid biosynthesis";"Jadomycin biosynthesis";"Aflatoxin biosynthesis";"Carbon fixation pathways in prokaryotes";"Biotin transport and metabolism";"Propanoate metabolism";"Pyruvate metabolism";"ChREBP activates metabolic gene expression"
Medex_00058662-RA	4	MetaCyc: PWY-7394;MetaCyc: PWY-7849;KEGG: 00230+4.1.1.97;MetaCyc: PWY-5691	"Urate conversion to allantoin II";"Urate conversion to allantoin III";"Purine metabolism";"Urate conversion to allantoin I"
Medex_00012913-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00025597-RA	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840	"Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation"
Medex_00016576-RA	56	Reactome: R-HSA-450408;Reactome: R-HSA-180585;Reactome: R-HSA-2467813;Reactome: R-HSA-4641258;Reactome: R-HSA-382556;Reactome: R-HSA-68949;Reactome: R-HSA-8939236;Reactome: R-HSA-211733;Reactome: R-HSA-9010553;Reactome: R-HSA-202424;Reactome: R-HSA-983168;Reactome: R-HSA-8941858;Reactome: R-HSA-5358346;Reactome: R-HSA-5658442;Reactome: R-HSA-9020702;Reactome: R-HSA-180534;Reactome: R-HSA-349425;Reactome: R-HSA-1236978;Reactome: R-HSA-5632684;Reactome: R-HSA-174178;Reactome: R-HSA-5610780;Reactome: R-HSA-8852276;Reactome: R-HSA-5607761;Reactome: R-HSA-195253;Reactome: R-HSA-75815;Reactome: R-HSA-8939902;Reactome: R-HSA-4608870;Reactome: R-HSA-5689603;Reactome: R-HSA-5668541;Reactome: R-HSA-5687128;Reactome: R-HSA-5689880;Reactome: R-HSA-5610785;Reactome: R-HSA-8854050;Reactome: R-HSA-1236974;Reactome: R-HSA-5610783;Reactome: R-HSA-174084;Reactome: R-HSA-187577;Reactome: R-HSA-174184;Reactome: R-HSA-5607764;Reactome: R-HSA-174154;Reactome: R-HSA-1169091;Reactome: R-HSA-2871837;Reactome: R-HSA-8951664;Reactome: R-HSA-4641257;Reactome: R-HSA-174113;Reactome: R-HSA-69481;Reactome: R-HSA-5678895;Reactome: R-HSA-350562;Reactome: R-HSA-8948751;Reactome: R-HSA-68827;Reactome: R-HSA-9604323;Reactome: R-HSA-5676590;Reactome: R-HSA-69017;Reactome: R-HSA-5362768;Reactome: R-HSA-1234176;Reactome: R-HSA-69601	"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Vif-mediated degradation of APOBEC3G";"Separation of Sister Chromatids";"Degradation of DVL";"ABC-family proteins mediated transport";"Orc1 removal from chromatin";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Regulation of expression of SLITs and ROBOs";"Downstream TCR signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Regulation of RUNX3 expression and activity";"Hedgehog ligand biogenesis";"Regulation of RAS by GAPs";"Interleukin-1 signaling";"Vpu mediated degradation of CD4";"Autodegradation of the E3 ubiquitin ligase COP1";"Cross-presentation of soluble exogenous antigens (endosomes)";"Hedgehog 'on' state";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Degradation of GLI1 by the proteasome";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Dectin-1 mediated noncanonical NF-kB signaling";"Degradation of beta-catenin by the destruction complex";"Ubiquitin-dependent degradation of Cyclin D";"Regulation of RUNX2 expression and activity";"Asymmetric localization of PCP proteins";"UCH proteinases";"TNFR2 non-canonical NF-kB pathway";"MAPK6/MAPK4 signaling";"Ub-specific processing proteases";"GLI3 is processed to GLI3R by the proteasome";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"ER-Phagosome pathway";"Degradation of GLI2 by the proteasome";"Autodegradation of Cdh1 by Cdh1:APC/C";"SCF(Skp2)-mediated degradation of p27/p21";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"CLEC7A (Dectin-1) signaling";"APC/C:Cdc20 mediated degradation of Securin";"Activation of NF-kappaB in B cells";"FCERI mediated NF-kB activation";"Neddylation";"Degradation of AXIN";"SCF-beta-TrCP mediated degradation of Emi1";"G2/M Checkpoints";"Defective CFTR causes cystic fibrosis";"Regulation of ornithine decarboxylase (ODC)";"Regulation of PTEN stability and activity";"CDT1 association with the CDC6:ORC:origin complex";"Negative regulation of NOTCH4 signaling";"NIK-->noncanonical NF-kB signaling";"CDK-mediated phosphorylation and removal of Cdc6";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A"
Medex_00082595-RA	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
Medex_00050048-RA	1	Reactome: R-HSA-8873719	"RAB geranylgeranylation"
Medex_00058823-RA	1	Reactome: R-HSA-419771	"Opsins"
Medex_00071388-RA	3	MetaCyc: PWY-7980;KEGG: 00190+7.1.2.2;KEGG: 00195+7.1.2.2	"ATP biosynthesis";"Oxidative phosphorylation";"Photosynthesis"
Medex_00056846-RA	3	Reactome: R-HSA-6807878;Reactome: R-HSA-6811440;Reactome: R-HSA-6811438	"COPI-mediated anterograde transport";"Retrograde transport at the Trans-Golgi-Network";"Intra-Golgi traffic"
Medex_00019535-RA	10	KEGG: 00564+2.3.1.15;MetaCyc: PWY-8051;MetaCyc: PWY-6453;MetaCyc: PWY-8053;Reactome: R-HSA-1483166;MetaCyc: PWY-7411;MetaCyc: PWY-7587;MetaCyc: PWY-5667;MetaCyc: PWY-8055;KEGG: 00561+2.3.1.15	"Glycerophospholipid metabolism";"Anandamide biosynthesis I";"Stigma estolide biosynthesis";"Anandamide biosynthesis II";"Synthesis of PA";"Phosphatidate biosynthesis (yeast)";"Oleate biosynthesis III (cyanobacteria)";"CDP-diacylglycerol biosynthesis I";"Palmitoyl ethanolamide biosynthesis";"Glycerolipid metabolism"
Medex_00074749-RA	12	Reactome: R-HSA-210744;Reactome: R-HSA-5250924;Reactome: R-HSA-350054;Reactome: R-HSA-8941856;Reactome: R-HSA-73762;Reactome: R-HSA-2644606;Reactome: R-HSA-2122947;Reactome: R-HSA-9013695;Reactome: R-HSA-3214847;Reactome: R-HSA-9013508;Reactome: R-HSA-2894862;Reactome: R-HSA-1912408	"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"B-WICH complex positively regulates rRNA expression";"Notch-HLH transcription pathway";"RUNX3 regulates NOTCH signaling";"RNA Polymerase I Transcription Initiation";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH1 Intracellular Domain Regulates Transcription";"NOTCH4 Intracellular Domain Regulates Transcription";"HATs acetylate histones";"NOTCH3 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Pre-NOTCH Transcription and Translation"
Medex_00015792-RA	1	Reactome: R-HSA-70895	"Branched-chain amino acid catabolism"
Medex_00022135-RA	13	Reactome: R-HSA-192823;Reactome: R-HSA-975957;Reactome: R-HSA-156902;Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-1799339;Reactome: R-HSA-72764;Reactome: R-HSA-72689;Reactome: R-HSA-72706;Reactome: R-HSA-975956;Reactome: R-HSA-6791226;Reactome: R-HSA-2408557	"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Peptide chain elongation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"SRP-dependent cotranslational protein targeting to membrane";"Eukaryotic Translation Termination";"Formation of a pool of free 40S subunits";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"Selenocysteine synthesis"
Medex_00017974-RA	2	Reactome: R-HSA-390471;Reactome: R-HSA-1660662	"Association of TriC/CCT with target proteins during biosynthesis";"Glycosphingolipid metabolism"
Medex_00066381-RA	7	KEGG: 00562+3.1.3.25;KEGG: 04070+3.1.3.25;MetaCyc: PWY-4702;MetaCyc: PWY-6363;Reactome: R-HSA-1855183;MetaCyc: PWY-2301;KEGG: 00521+3.1.3.25	"Inositol phosphate metabolism";"Phosphatidylinositol signaling system";"Phytate degradation I";"D-myo-inositol (1,4,5)-trisphosphate degradation";"Synthesis of IP2, IP, and Ins in the cytosol";"Myo-inositol biosynthesis";"Streptomycin biosynthesis"
Medex_00035193-RA	4	Reactome: R-HSA-674695;Reactome: R-HSA-112382;Reactome: R-HSA-8866654;Reactome: R-HSA-75955	"RNA Polymerase II Pre-transcription Events";"Formation of RNA Pol II elongation complex";"E3 ubiquitin ligases ubiquitinate target proteins";"RNA Polymerase II Transcription Elongation"
Medex_00058911-RA	5	Reactome: R-HSA-75105;Reactome: R-HSA-9029558;Reactome: R-HSA-199220;Reactome: R-HSA-163765;Reactome: R-HSA-2426168	"Fatty acyl-CoA biosynthesis";"NR1H2 & NR1H3 regulate gene expression linked to lipogenesis";"Vitamin B5 (pantothenate) metabolism";"ChREBP activates metabolic gene expression";"Activation of gene expression by SREBF (SREBP)"
Medex_00052225-RA	7	Reactome: R-HSA-73980;Reactome: R-HSA-76071;Reactome: R-HSA-1834949;Reactome: R-HSA-76061;Reactome: R-HSA-749476;Reactome: R-HSA-73780;Reactome: R-HSA-76066	"RNA Polymerase III Transcription Termination";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Chain Elongation";"RNA Polymerase III Transcription Initiation From Type 2 Promoter"
Medex_00014752-RA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
Medex_00012420-RA	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
Medex_00024317-RA	1	Reactome: R-HSA-9037629	"Lewis blood group biosynthesis"
Medex_00012402-RA	1	Reactome: R-HSA-432722	"Golgi Associated Vesicle Biogenesis"
Medex_00001464-RA	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5419276;Reactome: R-HSA-5389840	"Mitochondrial translation initiation";"Mitochondrial translation termination";"Mitochondrial translation elongation"
Medex_00060785-RA	1	Reactome: R-HSA-8951664	"Neddylation"
Medex_00038435-RA	4	Reactome: R-HSA-2894862;Reactome: R-HSA-350054;Reactome: R-HSA-2644606;Reactome: R-HSA-2122947	"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Notch-HLH transcription pathway";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH1 Intracellular Domain Regulates Transcription"
Medex_00055298-RA	12	Reactome: R-HSA-73772;Reactome: R-HSA-73762;Reactome: R-HSA-1834949;Reactome: R-HSA-5250924;Reactome: R-HSA-76066;Reactome: R-HSA-73863;Reactome: R-HSA-749476;Reactome: R-HSA-76071;Reactome: R-HSA-73980;Reactome: R-HSA-76061;Reactome: R-HSA-427413;Reactome: R-HSA-73780	"RNA Polymerase I Promoter Escape";"RNA Polymerase I Transcription Initiation";"Cytosolic sensors of pathogen-associated DNA";"B-WICH complex positively regulates rRNA expression";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase I Transcription Termination";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Transcription Termination";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"NoRC negatively regulates rRNA expression";"RNA Polymerase III Chain Elongation"
Medex_00037706-RA	1	Reactome: R-HSA-8951664	"Neddylation"
Medex_00051811-RA	8	MetaCyc: PWY-7979;KEGG: 00514+2.4.1.109;Reactome: R-HSA-5083633;Reactome: R-HSA-5173105;Reactome: R-HSA-5083629;MetaCyc: PWY-7922;KEGG: 00515+2.4.1.109;MetaCyc: PWY-7921	"Protein O-mannosylation III (mammals, core M3)";"Other types of O-glycan biosynthesis";"Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1";"O-linked glycosylation";"Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2";"Protein O-mannosylation II (mammals, core M1 and core M2)";"Mannose type O-glycan biosynthesis";"Protein O-mannosylation I (yeast)"
Medex_00084944-RA	7	MetaCyc: PWY-5484;KEGG: 00030+3.1.3.11;KEGG: 00710+3.1.3.11;KEGG: 00680+3.1.3.11;KEGG: 00051+3.1.3.11;Reactome: R-HSA-70263;KEGG: 00010+3.1.3.11	"Glycolysis II (from fructose 6-phosphate)";"Pentose phosphate pathway";"Carbon fixation in photosynthetic organisms";"Methane metabolism";"Fructose and mannose metabolism";"Gluconeogenesis";"Glycolysis / Gluconeogenesis"
Medex_00061984-RA	2	Reactome: R-HSA-429947;Reactome: R-HSA-6804115	"Deadenylation of mRNA";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"
Medex_00048048-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Medex_00055835-RA	5	Reactome: R-HSA-983170;Reactome: R-HSA-204005;Reactome: R-HSA-2132295;Reactome: R-HSA-5694530;Reactome: R-HSA-1655829	"Antigen Presentation: Folding, assembly and peptide loading of class I MHC";"COPII-mediated vesicle transport";"MHC class II antigen presentation";"Cargo concentration in the ER";"Regulation of cholesterol biosynthesis by SREBP (SREBF)"
Medex_00054090-RA	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
Medex_00035303-RA	9	Reactome: R-HSA-1368108;Reactome: R-HSA-2426168;Reactome: R-HSA-381340;Reactome: R-HSA-2151201;Reactome: R-HSA-400253;Reactome: R-HSA-1989781;Reactome: R-HSA-1368082;Reactome: R-HSA-400206;Reactome: R-HSA-191859	"BMAL1:CLOCK,NPAS2 activates circadian gene expression";"Activation of gene expression by SREBF (SREBP)";"Transcriptional regulation of white adipocyte differentiation";"Transcriptional activation of mitochondrial biogenesis";"Circadian Clock";"PPARA activates gene expression";"RORA activates gene expression";"Regulation of lipid metabolism by PPARalpha";"snRNP Assembly"
Medex_00058991-RA	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
Medex_00082636-RA	18	KEGG: 00950+2.6.1.1;KEGG: 00401+2.6.1.1;KEGG: 00400+2.6.1.1;KEGG: 00330+2.6.1.1;KEGG: 00960+2.6.1.1;KEGG: 00710+2.6.1.1;MetaCyc: PWY-7117;KEGG: 00250+2.6.1.1;MetaCyc: PWY-5913;MetaCyc: PWY-6643;KEGG: 00270+2.6.1.1;KEGG: 00360+2.6.1.1;KEGG: 00350+2.6.1.1;KEGG: 00220+2.6.1.1;MetaCyc: PWY-6642;MetaCyc: PWY-6638;MetaCyc: PWY-7115;MetaCyc: PWY-7383	"Isoquinoline alkaloid biosynthesis";"Novobiocin biosynthesis";"Phenylalanine, tyrosine and tryptophan biosynthesis";"Arginine and proline metabolism";"Tropane, piperidine and pyridine alkaloid biosynthesis";"Carbon fixation in photosynthetic organisms";"C4 photosynthetic carbon assimilation cycle, PEPCK type";"Alanine, aspartate and glutamate metabolism";"Partial TCA cycle (obligate autotrophs)";"Coenzyme M biosynthesis II";"Cysteine and methionine metabolism";"Phenylalanine metabolism";"Tyrosine metabolism";"Arginine biosynthesis";"(R)-cysteate degradation";"Sulfolactate degradation III";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"Anaerobic energy metabolism (invertebrates, cytosol)"
Medex_00054517-RA	3	Reactome: R-HSA-5655862;Reactome: R-HSA-5656121;Reactome: R-HSA-110312	"Translesion synthesis by POLK";"Translesion synthesis by POLI";"Translesion synthesis by REV1"
Medex_00075789-RA	12	Reactome: R-HSA-416476;KEGG: 04151+2.7.11.1;Reactome: R-HSA-193648;KEGG: 04926+2.7.11.1;Reactome: R-HSA-194840;KEGG: 05163+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;Reactome: R-HSA-418885;Reactome: R-HSA-416482;KEGG: 04714+2.7.11.1	"G alpha (q) signalling events";"PI3K-Akt signaling pathway";"NRAGE signals death through JNK";"Relaxin signaling pathway";"Rho GTPase cycle";"Human cytomegalovirus infection";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"Human papillomavirus infection";"DCC mediated attractive signaling";"G alpha (12/13) signalling events";"Thermogenesis"
Medex_00025190-RA	6	MetaCyc: PWY-5884;Reactome: R-HSA-9640463;KEGG: 00073+1.2.1.84;MetaCyc: PWY-7782;MetaCyc: PWY-6733;MetaCyc: PWY-7656	"Wax esters biosynthesis I";"Wax biosynthesis";"Cutin, suberine and wax biosynthesis";"Plasmalogen biosynthesis";"Sporopollenin precursors biosynthesis";"Spodoptera littoralis pheromone biosynthesis"
Medex_00003334-RA	1	Reactome: R-HSA-203927	"MicroRNA (miRNA) biogenesis"
Medex_00040313-RA	1	Reactome: R-HSA-163560	"Triglyceride catabolism"
Medex_00048103-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Medex_00070450-RA	6	MetaCyc: PWY-4381;MetaCyc: PWY-5743;MetaCyc: PWY-6722;MetaCyc: PWY-5744;MetaCyc: PWY-5789;Reactome: R-HSA-196780	"Fatty acid biosynthesis initiation (bacteria and plants)";"3-hydroxypropanoate cycle";"Candicidin biosynthesis";"Glyoxylate assimilation";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Biotin transport and metabolism"
Medex_00049504-RA	6	Reactome: R-HSA-181429;Reactome: R-HSA-210500;Reactome: R-HSA-388844;Reactome: R-HSA-181430;Reactome: R-HSA-212676;Reactome: R-HSA-264642	"Serotonin Neurotransmitter Release Cycle";"Glutamate Neurotransmitter Release Cycle";"Receptor-type tyrosine-protein phosphatases";"Norepinephrine Neurotransmitter Release Cycle";"Dopamine Neurotransmitter Release Cycle";"Acetylcholine Neurotransmitter Release Cycle"
Medex_00055923-RA	1	Reactome: R-HSA-2995383	"Initiation of Nuclear Envelope Reformation"
Medex_00003582-RA	3	Reactome: R-HSA-430039;Reactome: R-HSA-450513;Reactome: R-HSA-450385	"mRNA decay by 5' to 3' exoribonuclease";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA"
Medex_00090964-RA	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
Medex_00100716-RA	13	Reactome: R-HSA-2408557;Reactome: R-HSA-6791226;Reactome: R-HSA-72706;Reactome: R-HSA-975956;Reactome: R-HSA-72764;Reactome: R-HSA-72689;Reactome: R-HSA-1799339;Reactome: R-HSA-9633012;Reactome: R-HSA-156902;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-975957;Reactome: R-HSA-192823	"Selenocysteine synthesis";"Major pathway of rRNA processing in the nucleolus and cytosol";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Formation of a pool of free 40S subunits";"SRP-dependent cotranslational protein targeting to membrane";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Viral mRNA Translation"
Medex_00074488-RA	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
Medex_00068868-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Medex_00080253-RA	1	Reactome: R-HSA-5685939	"HDR through MMEJ (alt-NHEJ)"
Medex_00018886-RA	1	Reactome: R-HSA-216083	"Integrin cell surface interactions"
Medex_00003387-RA	33	Reactome: R-HSA-141444;Reactome: R-HSA-191859;Reactome: R-HSA-168325;Reactome: R-HSA-4551638;Reactome: R-HSA-170822;Reactome: R-HSA-168271;Reactome: R-HSA-3232142;Reactome: R-HSA-159230;Reactome: R-HSA-5663220;Reactome: R-HSA-68877;Reactome: R-HSA-159231;Reactome: R-HSA-9648025;Reactome: R-HSA-159227;Reactome: R-HSA-168333;Reactome: R-HSA-2467813;Reactome: R-HSA-1169408;Reactome: R-HSA-6784531;Reactome: R-HSA-3108214;Reactome: R-HSA-159236;Reactome: R-HSA-9610379;Reactome: R-HSA-5619107;Reactome: R-HSA-9609690;Reactome: R-HSA-4085377;Reactome: R-HSA-4570464;Reactome: R-HSA-180910;Reactome: R-HSA-3301854;Reactome: R-HSA-2500257;Reactome: R-HSA-168276;Reactome: R-HSA-5578749;Reactome: R-HSA-4615885;Reactome: R-HSA-3371453;Reactome: R-HSA-180746;Reactome: R-HSA-165054	"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"snRNP Assembly";"Viral Messenger RNA Synthesis";"SUMOylation of chromatin organization proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Transport of Ribonucleoproteins into the Host Nucleus";"SUMOylation of ubiquitinylation proteins";"Transport of the SLBP Dependant Mature mRNA";"RHO GTPases Activate Formins";"Mitotic Prometaphase";"Transport of Mature mRNA Derived from an Intronless Transcript";"EML4 and NUDC in mitotic spindle formation";"Transport of the SLBP independent Mature mRNA";"NEP/NS2 Interacts with the Cellular Export Machinery";"Separation of Sister Chromatids";"ISG15 antiviral mechanism";"tRNA processing in the nucleus";"SUMOylation of DNA damage response and repair proteins";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"HCMV Late Events";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"HCMV Early Events";"SUMOylation of SUMOylation proteins";"SUMOylation of RNA binding proteins";"Vpr-mediated nuclear import of PICs";"Nuclear Pore Complex (NPC) Disassembly";"Resolution of Sister Chromatid Cohesion";"NS1 Mediated Effects on Host Pathways";"Transcriptional regulation by small RNAs";"SUMOylation of DNA replication proteins";"Regulation of HSF1-mediated heat shock response";"Nuclear import of Rev protein";"Rev-mediated nuclear export of HIV RNA"
Medex_00005533-RA	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
Medex_00092083-RA	3	Reactome: R-HSA-416482;Reactome: R-HSA-194840;Reactome: R-HSA-193648	"G alpha (12/13) signalling events";"Rho GTPase cycle";"NRAGE signals death through JNK"
Medex_00038059-RA	6	MetaCyc: PWY-5884;Reactome: R-HSA-9640463;KEGG: 00073+1.2.1.84;MetaCyc: PWY-7656;MetaCyc: PWY-7782;MetaCyc: PWY-6733	"Wax esters biosynthesis I";"Wax biosynthesis";"Cutin, suberine and wax biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Plasmalogen biosynthesis";"Sporopollenin precursors biosynthesis"
Medex_00026152-RA	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
Medex_00009009-RA	2	Reactome: R-HSA-5685938;Reactome: R-HSA-3108214	"HDR through Single Strand Annealing (SSA)";"SUMOylation of DNA damage response and repair proteins"
Medex_00082017-RA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
Medex_00059314-RA	5	KEGG: 00720+4.2.1.3;KEGG: 00020+4.2.1.3;KEGG: 00630+4.2.1.3;KEGG: 00290+4.2.1.33;Reactome: R-HSA-917937	"Carbon fixation pathways in prokaryotes";"Citrate cycle (TCA cycle)";"Glyoxylate and dicarboxylate metabolism";"Valine, leucine and isoleucine biosynthesis";"Iron uptake and transport"
Medex_00074964-RA	1	Reactome: R-HSA-8951664	"Neddylation"
Medex_00060546-RA	2	Reactome: R-HSA-171319;Reactome: R-HSA-6790901	"Telomere Extension By Telomerase";"rRNA modification in the nucleus and cytosol"
Medex_00015768-RA	3	Reactome: R-HSA-4420097;KEGG: 04660+2.7.10.2;Reactome: R-HSA-391160	"VEGFA-VEGFR2 Pathway";"T cell receptor signaling pathway";"Signal regulatory protein family interactions"
Medex_00054764-RA	6	KEGG: 04070+3.1.3.56;KEGG: 00562+3.1.3.56;Reactome: R-HSA-1855183;MetaCyc: PWY-6363;MetaCyc: PWY-6364;MetaCyc: PWY-6362	"Phosphatidylinositol signaling system";"Inositol phosphate metabolism";"Synthesis of IP2, IP, and Ins in the cytosol";"D-myo-inositol (1,4,5)-trisphosphate degradation";"D-myo-inositol (1,3,4)-trisphosphate biosynthesis";"1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)"
Medex_00012780-RA	2	Reactome: R-HSA-1660662;Reactome: R-HSA-390471	"Glycosphingolipid metabolism";"Association of TriC/CCT with target proteins during biosynthesis"
Medex_00017067-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Medex_00093679-RA	2	Reactome: R-HSA-1660662;Reactome: R-HSA-390471	"Glycosphingolipid metabolism";"Association of TriC/CCT with target proteins during biosynthesis"
Medex_00090899-RA	7	KEGG: 00270+6.3.2.2;KEGG: 00480+6.3.2.2;Reactome: R-HSA-5578999;MetaCyc: PWY-8043;MetaCyc: PWY-7255;Reactome: R-HSA-174403;MetaCyc: PWY-6840	"Cysteine and methionine metabolism";"Glutathione metabolism";"Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD)";"Ophthalmate biosynthesis";"Ergothioneine biosynthesis I (bacteria)";"Glutathione synthesis and recycling";"Homoglutathione biosynthesis"
Medex_00100239-RA	5	Reactome: R-HSA-72163;Reactome: R-HSA-72187;Reactome: R-HSA-73856;Reactome: R-HSA-72165;Reactome: R-HSA-159236	"mRNA Splicing - Major Pathway";"mRNA 3'-end processing";"RNA Polymerase II Transcription Termination";"mRNA Splicing - Minor Pathway";"Transport of Mature mRNA derived from an Intron-Containing Transcript"
Medex_00031404-RA	5	Reactome: R-HSA-1169408;Reactome: R-HSA-936440;Reactome: R-HSA-6804756;Reactome: R-HSA-5668599;Reactome: R-HSA-6811555	"ISG15 antiviral mechanism";"Negative regulators of DDX58/IFIH1 signaling";"Regulation of TP53 Activity through Phosphorylation";"RHO GTPases Activate NADPH Oxidases";"PI5P Regulates TP53 Acetylation"
Medex_00092693-RA	2	Reactome: R-HSA-5696394;Reactome: R-HSA-5689603	"DNA Damage Recognition in GG-NER";"UCH proteinases"
Medex_00039159-RA	1	Reactome: R-HSA-380320	"Recruitment of NuMA to mitotic centrosomes"
Medex_00092763-RA	7	Reactome: R-HSA-73980;Reactome: R-HSA-76071;Reactome: R-HSA-1834949;Reactome: R-HSA-76061;Reactome: R-HSA-73780;Reactome: R-HSA-749476;Reactome: R-HSA-76066	"RNA Polymerase III Transcription Termination";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Chain Elongation";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 2 Promoter"
Medex_00078498-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Medex_00033117-RA	3	KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16	"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation"
Medex_00046458-RA	10	MetaCyc: PWY-5895;Reactome: R-HSA-2142789;MetaCyc: PWY-5890;MetaCyc: PWY-5849;MetaCyc: PWY-5892;MetaCyc: PWY-7996;MetaCyc: PWY-5891;MetaCyc: PWY-5844;MetaCyc: PWY-5839;KEGG: 00130+2.1.1.163	"Menaquinol-13 biosynthesis";"Ubiquinol biosynthesis";"Menaquinol-10 biosynthesis";"Menaquinol-6 biosynthesis";"Menaquinol-12 biosynthesis";"Menaquinol-4 biosynthesis I";"Menaquinol-11 biosynthesis";"Menaquinol-9 biosynthesis";"Menaquinol-7 biosynthesis";"Ubiquinone and other terpenoid-quinone biosynthesis"
Medex_00009154-RA	57	Reactome: R-HSA-5607764;Reactome: R-HSA-174184;Reactome: R-HSA-1169091;Reactome: R-HSA-174154;Reactome: R-HSA-8951664;Reactome: R-HSA-2871837;Reactome: R-HSA-174113;Reactome: R-HSA-4641257;Reactome: R-HSA-69481;Reactome: R-HSA-5678895;Reactome: R-HSA-350562;Reactome: R-HSA-68827;Reactome: R-HSA-9604323;Reactome: R-HSA-8948751;Reactome: R-HSA-69017;Reactome: R-HSA-5362768;Reactome: R-HSA-69601;Reactome: R-HSA-1234176;Reactome: R-HSA-5676590;Reactome: R-HSA-1236974;Reactome: R-HSA-8854050;Reactome: R-HSA-5610783;Reactome: R-HSA-187577;Reactome: R-HSA-174084;Reactome: R-HSA-1236978;Reactome: R-HSA-349425;Reactome: R-HSA-180534;Reactome: R-HSA-5632684;Reactome: R-HSA-174178;Reactome: R-HSA-5607761;Reactome: R-HSA-8852276;Reactome: R-HSA-5610780;Reactome: R-HSA-195253;Reactome: R-HSA-8939902;Reactome: R-HSA-75815;Reactome: R-HSA-5689603;Reactome: R-HSA-5668541;Reactome: R-HSA-5687128;Reactome: R-HSA-4608870;Reactome: R-HSA-5610785;Reactome: R-HSA-5689880;Reactome: R-HSA-180585;Reactome: R-HSA-450408;Reactome: R-HSA-4641258;Reactome: R-HSA-2467813;Reactome: R-HSA-9010553;Reactome: R-HSA-211733;Reactome: R-HSA-8939236;Reactome: R-HSA-68949;Reactome: R-HSA-382556;Reactome: R-HSA-983168;Reactome: R-HSA-202424;Reactome: R-HSA-5658442;Reactome: R-HSA-5358346;Reactome: R-HSA-8941858;Reactome: R-HSA-6798695;Reactome: R-HSA-9020702	"CLEC7A (Dectin-1) signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Activation of NF-kappaB in B cells";"APC/C:Cdc20 mediated degradation of Securin";"Neddylation";"FCERI mediated NF-kB activation";"SCF-beta-TrCP mediated degradation of Emi1";"Degradation of AXIN";"G2/M Checkpoints";"Defective CFTR causes cystic fibrosis";"Regulation of ornithine decarboxylase (ODC)";"CDT1 association with the CDC6:ORC:origin complex";"Negative regulation of NOTCH4 signaling";"Regulation of PTEN stability and activity";"CDK-mediated phosphorylation and removal of Cdc6";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"NIK-->noncanonical NF-kB signaling";"ER-Phagosome pathway";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Degradation of GLI2 by the proteasome";"SCF(Skp2)-mediated degradation of p27/p21";"Autodegradation of Cdh1 by Cdh1:APC/C";"Cross-presentation of soluble exogenous antigens (endosomes)";"Autodegradation of the E3 ubiquitin ligase COP1";"Vpu mediated degradation of CD4";"Hedgehog 'on' state";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Dectin-1 mediated noncanonical NF-kB signaling";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Degradation of GLI1 by the proteasome";"Degradation of beta-catenin by the destruction complex";"Regulation of RUNX2 expression and activity";"Ubiquitin-dependent degradation of Cyclin D";"UCH proteinases";"TNFR2 non-canonical NF-kB pathway";"MAPK6/MAPK4 signaling";"Asymmetric localization of PCP proteins";"GLI3 is processed to GLI3R by the proteasome";"Ub-specific processing proteases";"Vif-mediated degradation of APOBEC3G";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Degradation of DVL";"Separation of Sister Chromatids";"Regulation of expression of SLITs and ROBOs";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Orc1 removal from chromatin";"ABC-family proteins mediated transport";"Antigen processing: Ubiquitination & Proteasome degradation";"Downstream TCR signaling";"Regulation of RAS by GAPs";"Hedgehog ligand biogenesis";"Regulation of RUNX3 expression and activity";"Neutrophil degranulation";"Interleukin-1 signaling"
Medex_00009479-RA	6	Reactome: R-HSA-176187;Reactome: R-HSA-176974;Reactome: R-HSA-68962;Reactome: R-HSA-68867;Reactome: R-HSA-68949;Reactome: R-HSA-69052	"Activation of ATR in response to replication stress";"Unwinding of DNA";"Activation of the pre-replicative complex";"Assembly of the pre-replicative complex";"Orc1 removal from chromatin";"Switching of origins to a post-replicative state"
Medex_00051716-RA	9	KEGG: 00603+3.2.1.52;MetaCyc: PWY-7883;MetaCyc: PWY-6902;KEGG: 00520+3.2.1.52;KEGG: 00531+3.2.1.52;KEGG: 00513+3.2.1.52;MetaCyc: PWY-7822;KEGG: 00511+3.2.1.52;KEGG: 00604+3.2.1.52	"Glycosphingolipid biosynthesis - globo and isoglobo series";"Anhydromuropeptides recycling II";"Chitin degradation II (Vibrio)";"Amino sugar and nucleotide sugar metabolism";"Glycosaminoglycan degradation";"Various types of N-glycan biosynthesis";"Chitin degradation III (Serratia)";"Other glycan degradation";"Glycosphingolipid biosynthesis - ganglio series"
Medex_00093310-RA	30	Reactome: R-HSA-76042;Reactome: R-HSA-6782135;Reactome: R-HSA-167162;Reactome: R-HSA-75955;Reactome: R-HSA-2564830;Reactome: R-HSA-167160;Reactome: R-HSA-167246;Reactome: R-HSA-167200;Reactome: R-HSA-167172;Reactome: R-HSA-6781823;Reactome: R-HSA-73772;Reactome: R-HSA-6782210;Reactome: R-HSA-73776;Reactome: R-HSA-167152;Reactome: R-HSA-674695;Reactome: R-HSA-73863;Reactome: R-HSA-6796648;Reactome: R-HSA-5696400;Reactome: R-HSA-73779;Reactome: R-HSA-72086;Reactome: R-HSA-112382;Reactome: R-HSA-77075;Reactome: R-HSA-427413;Reactome: R-HSA-167158;Reactome: R-HSA-5696395;Reactome: R-HSA-6781827;Reactome: R-HSA-167161;Reactome: R-HSA-75953;Reactome: R-HSA-73762;Reactome: R-HSA-113418	"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Dual incision in TC-NER";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Elongation";"Cytosolic iron-sulfur cluster assembly";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Tat-mediated elongation of the HIV-1 transcript";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Transcription of the HIV genome";"Formation of TC-NER Pre-Incision Complex";"RNA Polymerase I Promoter Escape";"Gap-filling DNA repair synthesis and ligation in TC-NER";"RNA Polymerase II Promoter Escape";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase I Transcription Termination";"TP53 Regulates Transcription of DNA Repair Genes";"Dual Incision in GG-NER";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"mRNA Capping";"Formation of RNA Pol II elongation complex";"RNA Pol II CTD phosphorylation and interaction with CE";"NoRC negatively regulates rRNA expression";"Formation of the HIV-1 Early Elongation Complex";"Formation of Incision Complex in GG-NER";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"HIV Transcription Initiation";"RNA Polymerase II Transcription Initiation";"RNA Polymerase I Transcription Initiation";"Formation of the Early Elongation Complex"
Medex_00002986-RA	3	Reactome: R-HSA-1989781;Reactome: R-HSA-5678771;Reactome: R-HSA-382556	"PPARA activates gene expression";"Defective ABCB4 causes progressive familial intrahepatic cholestasis 3, intrahepatic cholestasis of pregnancy 3 and gallbladder disease 1";"ABC-family proteins mediated transport"
Medex_00017877-RA	1	Reactome: R-HSA-8951664	"Neddylation"
Medex_00081223-RA	2	MetaCyc: PWY-7851;KEGG: 00770+2.7.1.24	"Coenzyme A biosynthesis II (eukaryotic)";"Pantothenate and CoA biosynthesis"
Medex_00005902-RA	17	MetaCyc: PWY-5695;MetaCyc: PWY-6627;MetaCyc: PWY-6609;Reactome: R-HSA-74217;MetaCyc: PWY-6608;MetaCyc: PWY-5532;KEGG: 00240+2.4.2.1;MetaCyc: PWY-6620;MetaCyc: PWY-7179-1;KEGG: 00760+2.4.2.1;MetaCyc: PWY-6611;KEGG: 00230+2.4.2.1;MetaCyc: PWY-6644;MetaCyc: PWY-7179;Reactome: R-HSA-6798695;Reactome: R-HSA-74259;MetaCyc: PWY-4202	"Inosine 5'-phosphate degradation";"Salinosporamide A biosynthesis";"Adenine and adenosine salvage III";"Purine salvage";"Guanosine nucleotides degradation III";"Nucleoside and nucleotide degradation (archaea)";"Pyrimidine metabolism";"Guanine and guanosine salvage";"Purine deoxyribonucleosides degradation II";"Nicotinate and nicotinamide metabolism";"Adenine and adenosine salvage V";"Purine metabolism";"Fluoroacetate and fluorothreonine biosynthesis";"Purine deoxyribonucleosides degradation I";"Neutrophil degranulation";"Purine catabolism";"Arsenate detoxification I (mammalian)"
Medex_00009903-RA	1	Reactome: R-HSA-400253	"Circadian Clock"
Medex_00099789-RA	3	Reactome: R-HSA-425561;Reactome: R-HSA-418359;Reactome: R-HSA-5578775	"Sodium/Calcium exchangers";"Reduction of cytosolic Ca++ levels";"Ion homeostasis"
Medex_00086821-RA	3	MetaCyc: PWY-6348;KEGG: 00730+3.1.3.2;KEGG: 00740+3.1.3.2	"Phosphate acquisition";"Thiamine metabolism";"Riboflavin metabolism"
Medex_00093199-RA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
Medex_00004916-RA	2	KEGG: 00970+6.1.1.20;Reactome: R-HSA-379716	"Aminoacyl-tRNA biosynthesis";"Cytosolic tRNA aminoacylation"
Medex_00093298-RA	11	Reactome: R-HSA-450341;Reactome: R-HSA-6796648;Reactome: R-HSA-1912408;Reactome: R-HSA-9018519;Reactome: R-HSA-5617472;Reactome: R-HSA-2559582;Reactome: R-HSA-8943724;Reactome: R-HSA-5687128;Reactome: R-HSA-8862803;Reactome: R-HSA-2559580;Reactome: R-HSA-2871796	"Activation of the AP-1 family of transcription factors";"TP53 Regulates Transcription of DNA Repair Genes";"Pre-NOTCH Transcription and Translation";"Estrogen-dependent gene expression";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Senescence-Associated Secretory Phenotype (SASP)";"Regulation of PTEN gene transcription";"MAPK6/MAPK4 signaling";"Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models";"Oxidative Stress Induced Senescence";"FCERI mediated MAPK activation"
Medex_00088874-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Medex_00068179-RA	7	MetaCyc: PWY-6724;Reactome: R-HSA-70221;MetaCyc: PWY-7238;Reactome: R-HSA-6798695;MetaCyc: PWY-6737;KEGG: 00500+2.4.1.25;MetaCyc: PWY-5941	"Starch degradation II";"Glycogen breakdown (glycogenolysis)";"Sucrose biosynthesis II";"Neutrophil degranulation";"Starch degradation V";"Starch and sucrose metabolism";"Glycogen degradation II"
Medex_00023400-RA	2	Reactome: R-HSA-425366;Reactome: R-HSA-1483191	"Transport of bile salts and organic acids, metal ions and amine compounds";"Synthesis of PC"
Medex_00024491-RA	2	Reactome: R-HSA-390471;Reactome: R-HSA-1660662	"Association of TriC/CCT with target proteins during biosynthesis";"Glycosphingolipid metabolism"
Medex_00028697-RA	6	Reactome: R-HSA-5617472;Reactome: R-HSA-3769402;Reactome: R-HSA-8936459;Reactome: R-HSA-3214841;Reactome: R-HSA-201722;Reactome: R-HSA-8951664	"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Deactivation of the beta-catenin transactivating complex";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"PKMTs methylate histone lysines";"Formation of the beta-catenin:TCF transactivating complex";"Neddylation"
Medex_00008740-RA	2	Reactome: R-HSA-382556;Reactome: R-HSA-5678895	"ABC-family proteins mediated transport";"Defective CFTR causes cystic fibrosis"
Medex_00035397-RA	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
Medex_00015253-RA	1	Reactome: R-HSA-5693607	"Processing of DNA double-strand break ends"
Medex_00043934-RA	1	Reactome: R-HSA-162791	"Attachment of GPI anchor to uPAR"
Medex_00036815-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Medex_00035253-RA	6	Reactome: R-HSA-73817;MetaCyc: PWY-7234;KEGG: 00670+2.1.2.3;MetaCyc: PWY-6123;KEGG: 00230+3.5.4.10+2.1.2.3;MetaCyc: PWY-6124	"Purine ribonucleoside monophosphate biosynthesis";"Inosine-5'-phosphate biosynthesis III";"One carbon pool by folate";"Inosine-5'-phosphate biosynthesis I";"Purine metabolism";"Inosine-5'-phosphate biosynthesis II"
Medex_00018262-RA	1	Reactome: R-HSA-6790901	"rRNA modification in the nucleus and cytosol"
Medex_00021830-RA	5	Reactome: R-HSA-189451;MetaCyc: PWY-5188;MetaCyc: PWY-5189;Reactome: R-HSA-6798695;KEGG: 00860+4.2.1.24	"Heme biosynthesis";"Tetrapyrrole biosynthesis I (from glutamate)";"Tetrapyrrole biosynthesis II (from glycine)";"Neutrophil degranulation";"Porphyrin and chlorophyll metabolism"
Medex_00012914-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00010876-RA	7	Reactome: R-HSA-69205;Reactome: R-HSA-69656;Reactome: R-HSA-1362300;Reactome: R-HSA-1362277;Reactome: R-HSA-69202;Reactome: R-HSA-1538133;Reactome: R-HSA-156711	"G1/S-Specific Transcription";"Cyclin A:Cdk2-associated events at S phase entry";"Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1";"Transcription of E2F targets under negative control by DREAM complex";"Cyclin E associated events during G1/S transition";"G0 and Early G1";"Polo-like kinase mediated events"
Medex_00026150-RA	2	Reactome: R-HSA-8964038;Reactome: R-HSA-6798695	"LDL clearance";"Neutrophil degranulation"
Medex_00079715-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Medex_00041163-RA	15	Reactome: R-HSA-6796648;Reactome: R-HSA-167238;Reactome: R-HSA-75955;Reactome: R-HSA-112382;Reactome: R-HSA-167246;Reactome: R-HSA-167200;Reactome: R-HSA-167290;Reactome: R-HSA-167158;Reactome: R-HSA-167242;Reactome: R-HSA-167152;Reactome: R-HSA-674695;Reactome: R-HSA-113418;Reactome: R-HSA-167243;Reactome: R-HSA-167287;Reactome: R-HSA-9603505	"TP53 Regulates Transcription of DNA Repair Genes";"Pausing and recovery of Tat-mediated HIV elongation";"RNA Polymerase II Transcription Elongation";"Formation of RNA Pol II elongation complex";"Tat-mediated elongation of the HIV-1 transcript";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Pausing and recovery of HIV elongation";"Formation of the HIV-1 Early Elongation Complex";"Abortive elongation of HIV-1 transcript in the absence of Tat";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Polymerase II Pre-transcription Events";"Formation of the Early Elongation Complex";"Tat-mediated HIV elongation arrest and recovery";"HIV elongation arrest and recovery";"NTRK3 as a dependence receptor"
Medex_00028394-RA	13	MetaCyc: PWY-5392;KEGG: 00720+4.2.1.2;KEGG: 00020+4.2.1.2;MetaCyc: PWY-561;Reactome: R-HSA-71403;MetaCyc: PWY-5913;MetaCyc: PWY-6969;MetaCyc: PWY-6728;MetaCyc: PWY-7254;MetaCyc: PWY-7384;MetaCyc: PWY-8086;MetaCyc: PWY-5690;KEGG: 00620+4.2.1.2	"Reductive TCA cycle II";"Carbon fixation pathways in prokaryotes";"Citrate cycle (TCA cycle)";"Superpathway of glyoxylate cycle and fatty acid degradation";"Citric acid cycle (TCA cycle)";"Partial TCA cycle (obligate autotrophs)";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Methylaspartate cycle";"TCA cycle VII (acetate-producers)";"Anaerobic energy metabolism (invertebrates, mitochondrial)";"(S)-lactate fermentation to propanoate, acetate and hydrogen";"TCA cycle II (plants and fungi)";"Pyruvate metabolism"
Medex_00033254-RA	3	Reactome: R-HSA-5358493;MetaCyc: PWY-7546;MetaCyc: PWY-6482	"Synthesis of diphthamide-EEF2";"Diphthamide biosynthesis II (eukaryotes)";"Diphthamide biosynthesis I (archaea)"
Medex_00060007-RA	7	MetaCyc: PWY-2941;MetaCyc: PWY-2942;MetaCyc: PWY-5097;MetaCyc: PWY-8088;Reactome: R-HSA-389661;KEGG: 00261+4.3.3.7;KEGG: 00300+4.3.3.7	"L-lysine biosynthesis II";"L-lysine biosynthesis III";"L-lysine biosynthesis VI";"Dipicolinate biosynthesis";"Glyoxylate metabolism and glycine degradation";"Monobactam biosynthesis";"Lysine biosynthesis"
Medex_00013026-RA	1	KEGG: 00480+3.4.11.2	"Glutathione metabolism"
Medex_00072302-RA	2	Reactome: R-HSA-6811436;Reactome: R-HSA-8876198	"COPI-independent Golgi-to-ER retrograde traffic";"RAB GEFs exchange GTP for GDP on RABs"
Medex_00074227-RA	1	Reactome: R-HSA-110362	"POLB-Dependent Long Patch Base Excision Repair"
Medex_00086637-RA	2	Reactome: R-HSA-8939243;Reactome: R-HSA-3214858	"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RMTs methylate histone arginines"
Medex_00054429-RA	15	Reactome: R-HSA-2559580;Reactome: R-HSA-8853884;Reactome: R-HSA-8943723;Reactome: R-HSA-9022692;Reactome: R-HSA-9029569;Reactome: R-HSA-8948700;Reactome: R-HSA-4086398;Reactome: R-HSA-2559585;Reactome: R-HSA-5628897;Reactome: R-HSA-9018519;Reactome: R-HSA-1912408;Reactome: R-HSA-8936459;Reactome: R-HSA-8934593;Reactome: R-HSA-5687128;Reactome: R-HSA-8986944	"Oxidative Stress Induced Senescence";"Transcriptional Regulation by VENTX";"Regulation of PTEN mRNA translation";"Regulation of MECP2 expression and activity";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"Ca2+ pathway";"Oncogene Induced Senescence";"TP53 Regulates Metabolic Genes";"Estrogen-dependent gene expression";"Pre-NOTCH Transcription and Translation";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Regulation of RUNX1 Expression and Activity";"MAPK6/MAPK4 signaling";"Transcriptional Regulation by MECP2"
Medex_00052413-RA	6	Reactome: R-HSA-114508;MetaCyc: PWY-7039;KEGG: 00564+2.7.1.107;KEGG: 04070+2.7.1.107;MetaCyc: PWY-7817;KEGG: 00561+2.7.1.107	"Effects of PIP2 hydrolysis";"Phosphatidate metabolism, as a signaling molecule";"Glycerophospholipid metabolism";"Phosphatidylinositol signaling system";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Glycerolipid metabolism"
Medex_00026307-RA	2	Reactome: R-HSA-210745;Reactome: R-HSA-383280	"Regulation of gene expression in beta cells";"Nuclear Receptor transcription pathway"
Medex_00084916-RA	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276	"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination"
Medex_00078454-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00055837-RA	2	Reactome: R-HSA-6804115;Reactome: R-HSA-429947	"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Deadenylation of mRNA"
Medex_00056082-RA	1	Reactome: R-HSA-6811440	"Retrograde transport at the Trans-Golgi-Network"
Medex_00035629-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Medex_00093519-RA	8	Reactome: R-HSA-174430;Reactome: R-HSA-69166;Reactome: R-HSA-174411;Reactome: R-HSA-69183;Reactome: R-HSA-68962;Reactome: R-HSA-113501;Reactome: R-HSA-68952;Reactome: R-HSA-69091	"Telomere C-strand synthesis initiation";"Removal of the Flap Intermediate";"Polymerase switching on the C-strand of the telomere";"Processive synthesis on the lagging strand";"Activation of the pre-replicative complex";"Inhibition of replication initiation of damaged DNA by RB1/E2F1";"DNA replication initiation";"Polymerase switching"
Medex_00047831-RA	3	MetaCyc: PWY-6348;KEGG: 00740+3.1.3.2;KEGG: 00730+3.1.3.2	"Phosphate acquisition";"Riboflavin metabolism";"Thiamine metabolism"
Medex_00038828-RA	1	KEGG: 00290+4.2.1.33	"Valine, leucine and isoleucine biosynthesis"
Medex_00057826-RA	8	Reactome: R-HSA-69166;Reactome: R-HSA-174430;Reactome: R-HSA-68952;Reactome: R-HSA-69091;Reactome: R-HSA-69183;Reactome: R-HSA-174411;Reactome: R-HSA-68962;Reactome: R-HSA-113501	"Removal of the Flap Intermediate";"Telomere C-strand synthesis initiation";"DNA replication initiation";"Polymerase switching";"Processive synthesis on the lagging strand";"Polymerase switching on the C-strand of the telomere";"Activation of the pre-replicative complex";"Inhibition of replication initiation of damaged DNA by RB1/E2F1"
Medex_00005295-RA	1	Reactome: R-HSA-376172	"DSCAM interactions"
Medex_00022406-RA	15	KEGG: 00230+2.7.1.40;MetaCyc: PWY-2221;MetaCyc: PWY-6886;Reactome: R-HSA-70171;MetaCyc: PWY-5723;MetaCyc: PWY-1042;MetaCyc: PWY-6901;MetaCyc: PWY-6142;KEGG: 00620+2.7.1.40;MetaCyc: PWY-7003;MetaCyc: PWY-8004;KEGG: 00010+2.7.1.40;MetaCyc: PWY-7218;MetaCyc: PWY-5484;MetaCyc: PWY-7383	"Purine metabolism";"Entner-Doudoroff pathway III (semi-phosphorylative)";"1-butanol autotrophic biosynthesis (engineered)";"Glycolysis";"Rubisco shunt";"Glycolysis IV (plant cytosol)";"Superpathway of glucose and xylose degradation";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Pyruvate metabolism";"Glycerol degradation to butanol";"Entner-Doudoroff pathway I";"Glycolysis / Gluconeogenesis";"Photosynthetic 3-hydroxybutanoate biosynthesis (engineered)";"Glycolysis II (from fructose 6-phosphate)";"Anaerobic energy metabolism (invertebrates, cytosol)"
Medex_00019368-RA	3	Reactome: R-HSA-674695;Reactome: R-HSA-75955;Reactome: R-HSA-112382	"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Elongation";"Formation of RNA Pol II elongation complex"
Medex_00084206-RA	1	Reactome: R-HSA-373752	"Netrin-1 signaling"
Medex_00091802-RA	2	Reactome: R-HSA-8939243;Reactome: R-HSA-3214858	"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RMTs methylate histone arginines"
Medex_00012919-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00090283-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Medex_00064861-RA	5	KEGG: 00290+4.2.1.33;Reactome: R-HSA-917937;KEGG: 00020+4.2.1.3;KEGG: 00630+4.2.1.3;KEGG: 00720+4.2.1.3	"Valine, leucine and isoleucine biosynthesis";"Iron uptake and transport";"Citrate cycle (TCA cycle)";"Glyoxylate and dicarboxylate metabolism";"Carbon fixation pathways in prokaryotes"
Medex_00056012-RA	7	Reactome: R-HSA-6798695;MetaCyc: PWY-7238;Reactome: R-HSA-70221;MetaCyc: PWY-6724;MetaCyc: PWY-5941;KEGG: 00500+2.4.1.25;MetaCyc: PWY-6737	"Neutrophil degranulation";"Sucrose biosynthesis II";"Glycogen breakdown (glycogenolysis)";"Starch degradation II";"Glycogen degradation II";"Starch and sucrose metabolism";"Starch degradation V"
Medex_00002626-RA	6	MetaCyc: PWY-2221;MetaCyc: PWY-5530;KEGG: 00030+3.1.1.17;KEGG: 00930+3.1.1.17;MetaCyc: PWY-7165;KEGG: 00053+3.1.1.17	"Entner-Doudoroff pathway III (semi-phosphorylative)";"Sorbitol biosynthesis II";"Pentose phosphate pathway";"Caprolactam degradation";"L-ascorbate biosynthesis VI (engineered pathway)";"Ascorbate and aldarate metabolism"
Medex_00029769-RA	4	Reactome: R-HSA-2122948;Reactome: R-HSA-447043;Reactome: R-HSA-2979096;Reactome: R-HSA-373760	"Activated NOTCH1 Transmits Signal to the Nucleus";"Neurofascin interactions";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"L1CAM interactions"
Medex_00059054-RA	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
Medex_00014185-RA	1	KEGG: 00970+6.1.1.19	"Aminoacyl-tRNA biosynthesis"
Medex_00008754-RA	1	Reactome: R-HSA-2132295	"MHC class II antigen presentation"
Medex_00027078-RA	11	Reactome: R-HSA-6782135;Reactome: R-HSA-110314;Reactome: R-HSA-68962;Reactome: R-HSA-5696400;Reactome: R-HSA-68952;Reactome: R-HSA-5656169;Reactome: R-HSA-5651801;Reactome: R-HSA-174430;Reactome: R-HSA-6782210;Reactome: R-HSA-5696397;Reactome: R-HSA-5685942	"Dual incision in TC-NER";"Recognition of DNA damage by PCNA-containing replication complex";"Activation of the pre-replicative complex";"Dual Incision in GG-NER";"DNA replication initiation";"Termination of translesion DNA synthesis";"PCNA-Dependent Long Patch Base Excision Repair";"Telomere C-strand synthesis initiation";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Gap-filling DNA repair synthesis and ligation in GG-NER";"HDR through Homologous Recombination (HRR)"
Medex_00004782-RA	5	Reactome: R-HSA-9610379;Reactome: R-HSA-162588;Reactome: R-HSA-174490;Reactome: R-HSA-9615710;Reactome: R-HSA-917729	"HCMV Late Events";"Budding and maturation of HIV virion";"Membrane binding and targetting of GAG proteins";"Late endosomal microautophagy";"Endosomal Sorting Complex Required For Transport (ESCRT)"
Medex_00048376-RA	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
Medex_00039757-RA	1	Reactome: R-HSA-373080	"Class B/2 (Secretin family receptors)"
Medex_00055911-RA	1	Reactome: R-HSA-71288	"Creatine metabolism"
Medex_00061093-RA	5	Reactome: R-HSA-9029558;Reactome: R-HSA-75105;Reactome: R-HSA-199220;Reactome: R-HSA-2426168;Reactome: R-HSA-163765	"NR1H2 & NR1H3 regulate gene expression linked to lipogenesis";"Fatty acyl-CoA biosynthesis";"Vitamin B5 (pantothenate) metabolism";"Activation of gene expression by SREBF (SREBP)";"ChREBP activates metabolic gene expression"
Medex_00042102-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Medex_00045664-RA	7	MetaCyc: PWY-2941;MetaCyc: PWY-8088;MetaCyc: PWY-2942;MetaCyc: PWY-5097;KEGG: 00261+4.3.3.7;KEGG: 00300+4.3.3.7;Reactome: R-HSA-389661	"L-lysine biosynthesis II";"Dipicolinate biosynthesis";"L-lysine biosynthesis III";"L-lysine biosynthesis VI";"Monobactam biosynthesis";"Lysine biosynthesis";"Glyoxylate metabolism and glycine degradation"
Medex_00030940-RA	2	Reactome: R-HSA-1660662;Reactome: R-HSA-390471	"Glycosphingolipid metabolism";"Association of TriC/CCT with target proteins during biosynthesis"
Medex_00004074-RA	8	KEGG: 00520+2.7.1.1;KEGG: 00500+2.7.1.1;KEGG: 00521+2.7.1.1;KEGG: 00052+2.7.1.1;Reactome: R-HSA-70171;KEGG: 00010+2.7.1.1;KEGG: 00524+2.7.1.1;KEGG: 00051+2.7.1.1	"Amino sugar and nucleotide sugar metabolism";"Starch and sucrose metabolism";"Streptomycin biosynthesis";"Galactose metabolism";"Glycolysis";"Glycolysis / Gluconeogenesis";"Neomycin, kanamycin and gentamicin biosynthesis";"Fructose and mannose metabolism"
Medex_00049284-RA	1	Reactome: R-HSA-9633012	"Response of EIF2AK4 (GCN2) to amino acid deficiency"
Medex_00037740-RA	3	Reactome: R-HSA-6782135;Reactome: R-HSA-5696395;Reactome: R-HSA-5696400	"Dual incision in TC-NER";"Formation of Incision Complex in GG-NER";"Dual Incision in GG-NER"
Medex_00055225-RA	1	Reactome: R-HSA-432047	"Passive transport by Aquaporins"
Medex_00084351-RA	4	MetaCyc: PWY-5084;KEGG: 00310+1.2.4.2;KEGG: 00380+1.2.4.2;KEGG: 00020+1.2.4.2	"2-oxoglutarate decarboxylation to succinyl-CoA";"Lysine degradation";"Tryptophan metabolism";"Citrate cycle (TCA cycle)"
Medex_00046350-RA	3	Reactome: R-HSA-983168;Reactome: R-HSA-8951664;Reactome: R-HSA-390471	"Antigen processing: Ubiquitination & Proteasome degradation";"Neddylation";"Association of TriC/CCT with target proteins during biosynthesis"
Medex_00020615-RA	1	Reactome: R-HSA-912446	"Meiotic recombination"
Medex_00003704-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Medex_00101947-RA	1	KEGG: 00760+2.3.1.286	"Nicotinate and nicotinamide metabolism"
Medex_00097783-RA	1	Reactome: R-HSA-5617472	"Activation of anterior HOX genes in hindbrain development during early embryogenesis"
Medex_00052439-RA	1	Reactome: R-HSA-6798163	"Choline catabolism"
Medex_00010999-RA	1	Reactome: R-HSA-5620912	"Anchoring of the basal body to the plasma membrane"
Medex_00064862-RA	5	KEGG: 00290+4.2.1.33;Reactome: R-HSA-917937;KEGG: 00020+4.2.1.3;KEGG: 00630+4.2.1.3;KEGG: 00720+4.2.1.3	"Valine, leucine and isoleucine biosynthesis";"Iron uptake and transport";"Citrate cycle (TCA cycle)";"Glyoxylate and dicarboxylate metabolism";"Carbon fixation pathways in prokaryotes"
Medex_00047608-RA	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
Medex_00040905-RA	2	Reactome: R-HSA-167826;Reactome: R-HSA-167827	"The fatty acid cycling model";"The proton buffering model"
Medex_00084834-RA	1	KEGG: 00240+3.1.3.89	"Pyrimidine metabolism"
Medex_00036314-RA	4	Reactome: R-HSA-6794361;Reactome: R-HSA-8856825;Reactome: R-HSA-5250958;Reactome: R-HSA-8856828	"Neurexins and neuroligins";"Cargo recognition for clathrin-mediated endocytosis";"Toxicity of botulinum toxin type B (BoNT/B)";"Clathrin-mediated endocytosis"
Medex_00058555-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Medex_00009927-RA	7	KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1	"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Human cytomegalovirus infection";"Relaxin signaling pathway";"Thermogenesis"
Medex_00070405-RA	6	KEGG: 00052+3.2.1.23;KEGG: 00531+3.2.1.23;MetaCyc: PWY-6807;KEGG: 00511+3.2.1.23;KEGG: 00600+3.2.1.23;KEGG: 00604+3.2.1.23	"Galactose metabolism";"Glycosaminoglycan degradation";"Xyloglucan degradation II (exoglucanase)";"Other glycan degradation";"Sphingolipid metabolism";"Glycosphingolipid biosynthesis - ganglio series"
Medex_00039387-RA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
Medex_00071877-RA	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840	"Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation"
Medex_00074171-RA	5	Reactome: R-HSA-163765;Reactome: R-HSA-2426168;Reactome: R-HSA-199220;Reactome: R-HSA-75105;Reactome: R-HSA-9029558	"ChREBP activates metabolic gene expression";"Activation of gene expression by SREBF (SREBP)";"Vitamin B5 (pantothenate) metabolism";"Fatty acyl-CoA biosynthesis";"NR1H2 & NR1H3 regulate gene expression linked to lipogenesis"
Medex_00044110-RA	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
Medex_00036559-RA	13	MetaCyc: PWY-2261;KEGG: 00980+2.5.1.18;Reactome: R-HSA-196836;KEGG: 00480+2.5.1.18+1.8.5.1;MetaCyc: PWY-6842;KEGG: 00053+1.8.5.1;KEGG: 00982+2.5.1.18;MetaCyc: PWY-7533;KEGG: 00983+2.5.1.18;Reactome: R-HSA-156590;MetaCyc: PWY-7112;MetaCyc: PWY-4061;MetaCyc: PWY-6370	"Ascorbate glutathione cycle";"Metabolism of xenobiotics by cytochrome P450";"Vitamin C (ascorbate) metabolism";"Glutathione metabolism";"Glutathione-mediated detoxification II";"Ascorbate and aldarate metabolism";"Drug metabolism - cytochrome P450";"Gliotoxin biosynthesis";"Drug metabolism - other enzymes";"Glutathione conjugation";"4-hydroxy-2-nonenal detoxification";"Glutathione-mediated detoxification I";"Ascorbate recycling (cytosolic)"
Medex_00014165-RA	3	KEGG: 00730+3.1.3.1;MetaCyc: PWY-5491;KEGG: 00790+3.1.3.1	"Thiamine metabolism";"Diethylphosphate degradation";"Folate biosynthesis"
Medex_00020792-RA	1	Reactome: R-HSA-2132295	"MHC class II antigen presentation"
Medex_00068199-RA	7	Reactome: R-HSA-2691232;Reactome: R-HSA-2894862;Reactome: R-HSA-2660826;Reactome: R-HSA-9013507;Reactome: R-HSA-2644606;Reactome: R-HSA-2122948;Reactome: R-HSA-2979096	"Constitutive Signaling by NOTCH1 HD Domain Mutants";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Activated NOTCH1 Transmits Signal to the Nucleus";"NOTCH2 Activation and Transmission of Signal to the Nucleus"
Medex_00074204-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Medex_00015397-RA	1	Reactome: R-HSA-6811440	"Retrograde transport at the Trans-Golgi-Network"
Medex_00050622-RA	2	Reactome: R-HSA-6798695;Reactome: R-HSA-9020702	"Neutrophil degranulation";"Interleukin-1 signaling"
Medex_00060701-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Medex_00005634-RA	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
Medex_00044347-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00059466-RA	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
Medex_00009022-RA	1	Reactome: R-HSA-1362409	"Mitochondrial iron-sulfur cluster biogenesis"
Medex_00049089-RA	4	Reactome: R-HSA-5694530;Reactome: R-HSA-2132295;Reactome: R-HSA-204005;Reactome: R-HSA-6798695	"Cargo concentration in the ER";"MHC class II antigen presentation";"COPII-mediated vesicle transport";"Neutrophil degranulation"
Medex_00067985-RA	2	MetaCyc: PWY-7511;Reactome: R-HSA-6798695	"Protein ubiquitination";"Neutrophil degranulation"
Medex_00003637-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00071838-RA	4	KEGG: 00380+1.2.4.2;KEGG: 00020+1.2.4.2;KEGG: 00310+1.2.4.2;MetaCyc: PWY-5084	"Tryptophan metabolism";"Citrate cycle (TCA cycle)";"Lysine degradation";"2-oxoglutarate decarboxylation to succinyl-CoA"
Medex_00036780-RA	1	Reactome: R-HSA-159236	"Transport of Mature mRNA derived from an Intron-Containing Transcript"
Medex_00002898-RA	3	KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16	"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway"
Medex_00004918-RA	2	Reactome: R-HSA-877300;Reactome: R-HSA-2132295	"Interferon gamma signaling";"MHC class II antigen presentation"
Medex_00008809-RA	1	Reactome: R-HSA-5693607	"Processing of DNA double-strand break ends"
Medex_00019772-RA	2	Reactome: R-HSA-3214841;Reactome: R-HSA-8936459	"PKMTs methylate histone lysines";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"
Medex_00008833-RA	1	Reactome: R-HSA-9633012	"Response of EIF2AK4 (GCN2) to amino acid deficiency"
Medex_00002306-RA	5	Reactome: R-HSA-3214815;Reactome: R-HSA-6804758;Reactome: R-HSA-427389;Reactome: R-HSA-8943724;Reactome: R-HSA-73762	"HDACs deacetylate histones";"Regulation of TP53 Activity through Acetylation";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"Regulation of PTEN gene transcription";"RNA Polymerase I Transcription Initiation"
Medex_00055101-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Medex_00007901-RA	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5419276;Reactome: R-HSA-5368286	"Mitochondrial translation elongation";"Mitochondrial translation termination";"Mitochondrial translation initiation"
Medex_00073607-RA	7	KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1	"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Human cytomegalovirus infection";"Relaxin signaling pathway";"Thermogenesis"
Medex_00054966-RA	3	KEGG: 00511+3.2.1.51;MetaCyc: PWY-6807;Reactome: R-HSA-6798695	"Other glycan degradation";"Xyloglucan degradation II (exoglucanase)";"Neutrophil degranulation"
Medex_00050156-RA	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
Medex_00033852-RA	1	KEGG: 00970+6.1.1.14	"Aminoacyl-tRNA biosynthesis"
Medex_00066072-RA	7	KEGG: 04070+3.1.4.11;MetaCyc: PWY-8052;MetaCyc: PWY-6367;KEGG: 00562+3.1.4.11;Reactome: R-HSA-1855204;MetaCyc: PWY-6351;MetaCyc: PWY-7039	"Phosphatidylinositol signaling system";"2-arachidonoylglycerol biosynthesis";"D-myo-inositol-5-phosphate metabolism";"Inositol phosphate metabolism";"Synthesis of IP3 and IP4 in the cytosol";"D-myo-inositol (1,4,5)-trisphosphate biosynthesis";"Phosphatidate metabolism, as a signaling molecule"
Medex_00025148-RA	6	Reactome: R-HSA-2046106;Reactome: R-HSA-9033500;Reactome: R-HSA-9033241;Reactome: R-HSA-193368;Reactome: R-HSA-389887;Reactome: R-HSA-390247	"alpha-linolenic acid (ALA) metabolism";"TYSND1 cleaves peroxisomal proteins";"Peroxisomal protein import";"Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol";"Beta-oxidation of pristanoyl-CoA";"Beta-oxidation of very long chain fatty acids"
Medex_00046339-RA	2	Reactome: R-HSA-8964539;Reactome: R-HSA-2151201	"Glutamate and glutamine metabolism";"Transcriptional activation of mitochondrial biogenesis"
Medex_00012000-RA	2	KEGG: 00520+2.4.1.16;MetaCyc: PWY-6981	"Amino sugar and nucleotide sugar metabolism";"Chitin biosynthesis"
Medex_00041162-RA	15	Reactome: R-HSA-167158;Reactome: R-HSA-167290;Reactome: R-HSA-167242;Reactome: R-HSA-674695;Reactome: R-HSA-167152;Reactome: R-HSA-167243;Reactome: R-HSA-167287;Reactome: R-HSA-113418;Reactome: R-HSA-9603505;Reactome: R-HSA-6796648;Reactome: R-HSA-167238;Reactome: R-HSA-75955;Reactome: R-HSA-112382;Reactome: R-HSA-167246;Reactome: R-HSA-167200	"Formation of the HIV-1 Early Elongation Complex";"Pausing and recovery of HIV elongation";"Abortive elongation of HIV-1 transcript in the absence of Tat";"RNA Polymerase II Pre-transcription Events";"Formation of HIV elongation complex in the absence of HIV Tat";"Tat-mediated HIV elongation arrest and recovery";"HIV elongation arrest and recovery";"Formation of the Early Elongation Complex";"NTRK3 as a dependence receptor";"TP53 Regulates Transcription of DNA Repair Genes";"Pausing and recovery of Tat-mediated HIV elongation";"RNA Polymerase II Transcription Elongation";"Formation of RNA Pol II elongation complex";"Tat-mediated elongation of the HIV-1 transcript";"Formation of HIV-1 elongation complex containing HIV-1 Tat"
Medex_00033701-RA	57	Reactome: R-HSA-2871837;Reactome: R-HSA-8951664;Reactome: R-HSA-174184;Reactome: R-HSA-5607764;Reactome: R-HSA-174154;Reactome: R-HSA-1169091;Reactome: R-HSA-8948751;Reactome: R-HSA-9604323;Reactome: R-HSA-68827;Reactome: R-HSA-5676590;Reactome: R-HSA-5362768;Reactome: R-HSA-1234176;Reactome: R-HSA-69601;Reactome: R-HSA-69017;Reactome: R-HSA-4641257;Reactome: R-HSA-174113;Reactome: R-HSA-5678895;Reactome: R-HSA-350562;Reactome: R-HSA-69481;Reactome: R-HSA-8854050;Reactome: R-HSA-1236974;Reactome: R-HSA-5610783;Reactome: R-HSA-174084;Reactome: R-HSA-187577;Reactome: R-HSA-174178;Reactome: R-HSA-5610780;Reactome: R-HSA-8852276;Reactome: R-HSA-5607761;Reactome: R-HSA-180534;Reactome: R-HSA-1236978;Reactome: R-HSA-349425;Reactome: R-HSA-5632684;Reactome: R-HSA-4608870;Reactome: R-HSA-5689603;Reactome: R-HSA-5668541;Reactome: R-HSA-5687128;Reactome: R-HSA-5610785;Reactome: R-HSA-5689880;Reactome: R-HSA-195253;Reactome: R-HSA-75815;Reactome: R-HSA-8939902;Reactome: R-HSA-68949;Reactome: R-HSA-211733;Reactome: R-HSA-382556;Reactome: R-HSA-8939236;Reactome: R-HSA-9010553;Reactome: R-HSA-450408;Reactome: R-HSA-180585;Reactome: R-HSA-2467813;Reactome: R-HSA-4641258;Reactome: R-HSA-6798695;Reactome: R-HSA-9020702;Reactome: R-HSA-202424;Reactome: R-HSA-983168;Reactome: R-HSA-5358346;Reactome: R-HSA-8941858;Reactome: R-HSA-5658442	"FCERI mediated NF-kB activation";"Neddylation";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"CLEC7A (Dectin-1) signaling";"APC/C:Cdc20 mediated degradation of Securin";"Activation of NF-kappaB in B cells";"Regulation of PTEN stability and activity";"Negative regulation of NOTCH4 signaling";"CDT1 association with the CDC6:ORC:origin complex";"NIK-->noncanonical NF-kB signaling";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"CDK-mediated phosphorylation and removal of Cdc6";"Degradation of AXIN";"SCF-beta-TrCP mediated degradation of Emi1";"Defective CFTR causes cystic fibrosis";"Regulation of ornithine decarboxylase (ODC)";"G2/M Checkpoints";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"ER-Phagosome pathway";"Degradation of GLI2 by the proteasome";"Autodegradation of Cdh1 by Cdh1:APC/C";"SCF(Skp2)-mediated degradation of p27/p21";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Degradation of GLI1 by the proteasome";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Dectin-1 mediated noncanonical NF-kB signaling";"Vpu mediated degradation of CD4";"Cross-presentation of soluble exogenous antigens (endosomes)";"Autodegradation of the E3 ubiquitin ligase COP1";"Hedgehog 'on' state";"Asymmetric localization of PCP proteins";"UCH proteinases";"TNFR2 non-canonical NF-kB pathway";"MAPK6/MAPK4 signaling";"GLI3 is processed to GLI3R by the proteasome";"Ub-specific processing proteases";"Degradation of beta-catenin by the destruction complex";"Ubiquitin-dependent degradation of Cyclin D";"Regulation of RUNX2 expression and activity";"Orc1 removal from chromatin";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"ABC-family proteins mediated transport";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Regulation of expression of SLITs and ROBOs";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Vif-mediated degradation of APOBEC3G";"Separation of Sister Chromatids";"Degradation of DVL";"Neutrophil degranulation";"Interleukin-1 signaling";"Downstream TCR signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Hedgehog ligand biogenesis";"Regulation of RUNX3 expression and activity";"Regulation of RAS by GAPs"
Medex_00090591-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Medex_00046572-RA	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
Medex_00018020-RA	1	Reactome: R-HSA-5662702	"Melanin biosynthesis"
Medex_00001714-RA	2	Reactome: R-HSA-8866423;Reactome: R-HSA-8963888	"VLDL assembly";"Chylomicron assembly"
Medex_00006487-RA	1	KEGG: 00480+3.4.11.2	"Glutathione metabolism"
Medex_00032624-RA	10	KEGG: 00900+2.3.3.10;KEGG: 00072+2.3.3.10;KEGG: 00280+2.3.3.10;MetaCyc: PWY-7524;Reactome: R-HSA-1989781;MetaCyc: PWY-7391;MetaCyc: PWY-6174;MetaCyc: PWY-7571;KEGG: 00650+2.3.3.10;MetaCyc: PWY-922	"Terpenoid backbone biosynthesis";"Synthesis and degradation of ketone bodies";"Valine, leucine and isoleucine degradation";"Mevalonate pathway III (archaea)";"PPARA activates gene expression";"Isoprene biosynthesis II (engineered)";"Mevalonate pathway II (archaea)";"Ferrichrome A biosynthesis";"Butanoate metabolism";"Mevalonate pathway I"
Medex_00083614-RA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
Medex_00047264-RA	7	KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1	"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Human cytomegalovirus infection";"Relaxin signaling pathway";"Thermogenesis"
Medex_00008109-RA	7	Reactome: R-HSA-380284;Reactome: R-HSA-5620912;Reactome: R-HSA-380320;Reactome: R-HSA-380270;Reactome: R-HSA-8854518;Reactome: R-HSA-2565942;Reactome: R-HSA-380259	"Loss of proteins required for interphase microtubule organization from the centrosome";"Anchoring of the basal body to the plasma membrane";"Recruitment of NuMA to mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes";"AURKA Activation by TPX2";"Regulation of PLK1 Activity at G2/M Transition";"Loss of Nlp from mitotic centrosomes"
Medex_00034966-RA	1	Reactome: R-HSA-1660662	"Glycosphingolipid metabolism"
Medex_00071367-RA	2	Reactome: R-HSA-6807878;Reactome: R-HSA-6811434	"COPI-mediated anterograde transport";"COPI-dependent Golgi-to-ER retrograde traffic"
Medex_00053735-RA	16	Reactome: R-HSA-192823;Reactome: R-HSA-72649;Reactome: R-HSA-72695;Reactome: R-HSA-156902;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-72689;Reactome: R-HSA-2408557;Reactome: R-HSA-975957;Reactome: R-HSA-1799339;Reactome: R-HSA-9633012;Reactome: R-HSA-72706;Reactome: R-HSA-975956;Reactome: R-HSA-72764;Reactome: R-HSA-72702;Reactome: R-HSA-6791226	"Viral mRNA Translation";"Translation initiation complex formation";"Formation of the ternary complex, and subsequently, the 43S complex";"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Formation of a pool of free 40S subunits";"Selenocysteine synthesis";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Ribosomal scanning and start codon recognition";"Major pathway of rRNA processing in the nucleolus and cytosol"
Medex_00054842-RA	1	Reactome: R-HSA-9037629	"Lewis blood group biosynthesis"
Medex_00016067-RA	3	Reactome: R-HSA-110312;Reactome: R-HSA-5656121;Reactome: R-HSA-5655862	"Translesion synthesis by REV1";"Translesion synthesis by POLI";"Translesion synthesis by POLK"
Medex_00069345-RA	7	Reactome: R-HSA-2691232;Reactome: R-HSA-2894862;Reactome: R-HSA-2644606;Reactome: R-HSA-9013507;Reactome: R-HSA-2660826;Reactome: R-HSA-2979096;Reactome: R-HSA-2122948	"Constitutive Signaling by NOTCH1 HD Domain Mutants";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Activated NOTCH1 Transmits Signal to the Nucleus"
Medex_00031930-RA	2	Reactome: R-HSA-8939243;Reactome: R-HSA-3214858	"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RMTs methylate histone arginines"
Medex_00087934-RA	4	Reactome: R-HSA-2132295;Reactome: R-HSA-3371497;Reactome: R-HSA-6811436;Reactome: R-HSA-6807878	"MHC class II antigen presentation";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-independent Golgi-to-ER retrograde traffic";"COPI-mediated anterograde transport"
Medex_00000076-RA	1	KEGG: 00480+3.4.11.2	"Glutathione metabolism"
Medex_00078056-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00089202-RA	57	Reactome: R-HSA-450408;Reactome: R-HSA-180585;Reactome: R-HSA-2467813;Reactome: R-HSA-4641258;Reactome: R-HSA-211733;Reactome: R-HSA-8939236;Reactome: R-HSA-382556;Reactome: R-HSA-68949;Reactome: R-HSA-9010553;Reactome: R-HSA-202424;Reactome: R-HSA-983168;Reactome: R-HSA-5358346;Reactome: R-HSA-8941858;Reactome: R-HSA-5658442;Reactome: R-HSA-6798695;Reactome: R-HSA-9020702;Reactome: R-HSA-180534;Reactome: R-HSA-1236978;Reactome: R-HSA-349425;Reactome: R-HSA-5632684;Reactome: R-HSA-174178;Reactome: R-HSA-5610780;Reactome: R-HSA-8852276;Reactome: R-HSA-5607761;Reactome: R-HSA-195253;Reactome: R-HSA-75815;Reactome: R-HSA-8939902;Reactome: R-HSA-4608870;Reactome: R-HSA-5689603;Reactome: R-HSA-5668541;Reactome: R-HSA-5687128;Reactome: R-HSA-5610785;Reactome: R-HSA-5689880;Reactome: R-HSA-8854050;Reactome: R-HSA-1236974;Reactome: R-HSA-5610783;Reactome: R-HSA-174084;Reactome: R-HSA-187577;Reactome: R-HSA-5607764;Reactome: R-HSA-174184;Reactome: R-HSA-174154;Reactome: R-HSA-1169091;Reactome: R-HSA-2871837;Reactome: R-HSA-8951664;Reactome: R-HSA-4641257;Reactome: R-HSA-174113;Reactome: R-HSA-350562;Reactome: R-HSA-5678895;Reactome: R-HSA-69481;Reactome: R-HSA-9604323;Reactome: R-HSA-68827;Reactome: R-HSA-8948751;Reactome: R-HSA-5676590;Reactome: R-HSA-69017;Reactome: R-HSA-5362768;Reactome: R-HSA-69601;Reactome: R-HSA-1234176	"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Vif-mediated degradation of APOBEC3G";"Separation of Sister Chromatids";"Degradation of DVL";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"ABC-family proteins mediated transport";"Orc1 removal from chromatin";"Regulation of expression of SLITs and ROBOs";"Downstream TCR signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Hedgehog ligand biogenesis";"Regulation of RUNX3 expression and activity";"Regulation of RAS by GAPs";"Neutrophil degranulation";"Interleukin-1 signaling";"Vpu mediated degradation of CD4";"Cross-presentation of soluble exogenous antigens (endosomes)";"Autodegradation of the E3 ubiquitin ligase COP1";"Hedgehog 'on' state";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Degradation of GLI1 by the proteasome";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Dectin-1 mediated noncanonical NF-kB signaling";"Degradation of beta-catenin by the destruction complex";"Ubiquitin-dependent degradation of Cyclin D";"Regulation of RUNX2 expression and activity";"Asymmetric localization of PCP proteins";"UCH proteinases";"TNFR2 non-canonical NF-kB pathway";"MAPK6/MAPK4 signaling";"GLI3 is processed to GLI3R by the proteasome";"Ub-specific processing proteases";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"ER-Phagosome pathway";"Degradation of GLI2 by the proteasome";"Autodegradation of Cdh1 by Cdh1:APC/C";"SCF(Skp2)-mediated degradation of p27/p21";"CLEC7A (Dectin-1) signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"APC/C:Cdc20 mediated degradation of Securin";"Activation of NF-kappaB in B cells";"FCERI mediated NF-kB activation";"Neddylation";"Degradation of AXIN";"SCF-beta-TrCP mediated degradation of Emi1";"Regulation of ornithine decarboxylase (ODC)";"Defective CFTR causes cystic fibrosis";"G2/M Checkpoints";"Negative regulation of NOTCH4 signaling";"CDT1 association with the CDC6:ORC:origin complex";"Regulation of PTEN stability and activity";"NIK-->noncanonical NF-kB signaling";"CDK-mediated phosphorylation and removal of Cdc6";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha"
Medex_00073672-RA	6	Reactome: R-HSA-73856;Reactome: R-HSA-72163;Reactome: R-HSA-111367;Reactome: R-HSA-72165;Reactome: R-HSA-191859;Reactome: R-HSA-77588	"RNA Polymerase II Transcription Termination";"mRNA Splicing - Major Pathway";"SLBP independent Processing of Histone Pre-mRNAs";"mRNA Splicing - Minor Pathway";"snRNP Assembly";"SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs"
Medex_00056250-RA	1	Reactome: R-HSA-3214858	"RMTs methylate histone arginines"
Medex_00101280-RA	2	Reactome: R-HSA-72163;Reactome: R-HSA-72165	"mRNA Splicing - Major Pathway";"mRNA Splicing - Minor Pathway"
Medex_00003246-RA	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
Medex_00013455-RA	12	KEGG: 00680+4.1.2.13;MetaCyc: PWY-1042;KEGG: 00030+4.1.2.13;MetaCyc: PWY-6142;Reactome: R-HSA-70171;Reactome: R-HSA-70263;KEGG: 00710+4.1.2.13;MetaCyc: PWY-1861;MetaCyc: PWY-5484;KEGG: 00010+4.1.2.13;KEGG: 00051+4.1.2.13;MetaCyc: PWY-7385	"Methane metabolism";"Glycolysis IV (plant cytosol)";"Pentose phosphate pathway";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Glycolysis";"Gluconeogenesis";"Carbon fixation in photosynthetic organisms";"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"Glycolysis II (from fructose 6-phosphate)";"Glycolysis / Gluconeogenesis";"Fructose and mannose metabolism";"1,3-propanediol biosynthesis (engineered)"
Medex_00078317-RA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00058884-RA	1	Reactome: R-HSA-380972	"Energy dependent regulation of mTOR by LKB1-AMPK"
Medex_00001785-RA	6	MetaCyc: PWY-5884;Reactome: R-HSA-9640463;MetaCyc: PWY-6733;MetaCyc: PWY-7782;MetaCyc: PWY-7656;KEGG: 00073+1.2.1.84	"Wax esters biosynthesis I";"Wax biosynthesis";"Sporopollenin precursors biosynthesis";"Plasmalogen biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Cutin, suberine and wax biosynthesis"
Medex_00071546-RA	7	Reactome: R-HSA-5628897;Reactome: R-HSA-380972;Reactome: R-HSA-166208;Reactome: R-HSA-8943724;Reactome: R-HSA-1632852;Reactome: R-HSA-9639288;Reactome: R-HSA-165159	"TP53 Regulates Metabolic Genes";"Energy dependent regulation of mTOR by LKB1-AMPK";"mTORC1-mediated signalling";"Regulation of PTEN gene transcription";"Macroautophagy";"Amino acids regulate mTORC1";"mTOR signalling"
Medex_00057230-RA	4	Reactome: R-HSA-2467813;Reactome: R-HSA-2470946;Reactome: R-HSA-2500257;Reactome: R-HSA-2468052	"Separation of Sister Chromatids";"Cohesin Loading onto Chromatin";"Resolution of Sister Chromatid Cohesion";"Establishment of Sister Chromatid Cohesion"
Medex_00085009-RA	3	Reactome: R-HSA-72163;Reactome: R-HSA-5250924;Reactome: R-HSA-72165	"mRNA Splicing - Major Pathway";"B-WICH complex positively regulates rRNA expression";"mRNA Splicing - Minor Pathway"
Medex_00026606-RA	1	Reactome: R-HSA-1474228	"Degradation of the extracellular matrix"
Medex_00081523-RA	2	Reactome: R-HSA-1296052;Reactome: R-HSA-418457	"Ca2+ activated K+ channels";"cGMP effects"
Medex_00068173-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Medex_00081790-RA	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
Medex_00041364-RA	1	Reactome: R-HSA-70171	"Glycolysis"
Medex_00010028-RA	2	MetaCyc: PWY-7221;KEGG: 00230+2.7.4.8	"Guanosine ribonucleotides de novo biosynthesis";"Purine metabolism"
Medex_00046117-RA	1	KEGG: 00900+3.4.24.84	"Terpenoid backbone biosynthesis"
Medex_00003857-RA	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
Medex_00028398-RA	13	KEGG: 00720+4.2.1.2;MetaCyc: PWY-5392;Reactome: R-HSA-71403;MetaCyc: PWY-561;KEGG: 00020+4.2.1.2;MetaCyc: PWY-6969;MetaCyc: PWY-5913;MetaCyc: PWY-6728;MetaCyc: PWY-5690;KEGG: 00620+4.2.1.2;MetaCyc: PWY-7254;MetaCyc: PWY-8086;MetaCyc: PWY-7384	"Carbon fixation pathways in prokaryotes";"Reductive TCA cycle II";"Citric acid cycle (TCA cycle)";"Superpathway of glyoxylate cycle and fatty acid degradation";"Citrate cycle (TCA cycle)";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Partial TCA cycle (obligate autotrophs)";"Methylaspartate cycle";"TCA cycle II (plants and fungi)";"Pyruvate metabolism";"TCA cycle VII (acetate-producers)";"(S)-lactate fermentation to propanoate, acetate and hydrogen";"Anaerobic energy metabolism (invertebrates, mitochondrial)"
Medex_00085742-RA	6	Reactome: R-HSA-72706;Reactome: R-HSA-72689;Reactome: R-HSA-72702;Reactome: R-HSA-72649;Reactome: R-HSA-156827;Reactome: R-HSA-72695	"GTP hydrolysis and joining of the 60S ribosomal subunit";"Formation of a pool of free 40S subunits";"Ribosomal scanning and start codon recognition";"Translation initiation complex formation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Formation of the ternary complex, and subsequently, the 43S complex"
Medex_00052668-RA	9	Reactome: R-HSA-76042;Reactome: R-HSA-167162;Reactome: R-HSA-73779;Reactome: R-HSA-6804756;Reactome: R-HSA-167172;Reactome: R-HSA-167161;Reactome: R-HSA-75953;Reactome: R-HSA-73776;Reactome: R-HSA-674695	"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Regulation of TP53 Activity through Phosphorylation";"Transcription of the HIV genome";"HIV Transcription Initiation";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Pre-transcription Events"
Medex_00012905-RA	1	Reactome: R-HSA-389661	"Glyoxylate metabolism and glycine degradation"
Medex_00014228-RA	5	MetaCyc: PWY-7536;Reactome: R-HSA-189451;KEGG: 00860+2.3.1.37;KEGG: 00260+2.3.1.37;MetaCyc: PWY-5189	"2-amino-3-hydroxycyclopent-2-enone biosynthesis";"Heme biosynthesis";"Porphyrin and chlorophyll metabolism";"Glycine, serine and threonine metabolism";"Tetrapyrrole biosynthesis II (from glycine)"
Medex_00081818-RA	13	Reactome: R-HSA-2022857;KEGG: 00511+3.2.1.52;KEGG: 00513+3.2.1.52;MetaCyc: PWY-7822;Reactome: R-HSA-2024101;Reactome: R-HSA-1660662;KEGG: 00604+3.2.1.52;MetaCyc: PWY-7883;MetaCyc: PWY-6902;KEGG: 00603+3.2.1.52;KEGG: 00520+3.2.1.52;KEGG: 00531+3.2.1.52;Reactome: R-HSA-2160916	"Keratan sulfate degradation";"Other glycan degradation";"Various types of N-glycan biosynthesis";"Chitin degradation III (Serratia)";"CS/DS degradation";"Glycosphingolipid metabolism";"Glycosphingolipid biosynthesis - ganglio series";"Anhydromuropeptides recycling II";"Chitin degradation II (Vibrio)";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Amino sugar and nucleotide sugar metabolism";"Glycosaminoglycan degradation";"Hyaluronan uptake and degradation"
Medex_00073283-RA	1	Reactome: R-HSA-901032	"ER Quality Control Compartment (ERQC)"
Medex_00009089-RA	3	Reactome: R-HSA-72165;Reactome: R-HSA-191859;Reactome: R-HSA-72163	"mRNA Splicing - Minor Pathway";"snRNP Assembly";"mRNA Splicing - Major Pathway"
Medex_00038202-RA	2	Reactome: R-HSA-71403;Reactome: R-HSA-611105	"Citric acid cycle (TCA cycle)";"Respiratory electron transport"
Medex_00083160-RA	6	Reactome: R-HSA-5632927;Reactome: R-HSA-5632968;Reactome: R-HSA-5358606;Reactome: R-HSA-6796648;Reactome: R-HSA-5632928;Reactome: R-HSA-5358565	"Defective Mismatch Repair Associated With MSH3";"Defective Mismatch Repair Associated With MSH6";"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"TP53 Regulates Transcription of DNA Repair Genes";"Defective Mismatch Repair Associated With MSH2";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)"
Medex_00079774-RA	1	Reactome: R-HSA-389977	"Post-chaperonin tubulin folding pathway"
Medex_00008563-RA	2	Reactome: R-HSA-3295583;Reactome: R-HSA-418890	"TRP channels";"Role of second messengers in netrin-1 signaling"
Medex_00011337-RA	10	KEGG: 00600+3.2.1.23;Reactome: R-HSA-2160916;Reactome: R-HSA-2206292;KEGG: 00531+3.2.1.23;KEGG: 00052+3.2.1.23;Reactome: R-HSA-6798695;KEGG: 00511+3.2.1.23;MetaCyc: PWY-6807;KEGG: 00604+3.2.1.23;Reactome: R-HSA-2024096	"Sphingolipid metabolism";"Hyaluronan uptake and degradation";"MPS VII - Sly syndrome";"Glycosaminoglycan degradation";"Galactose metabolism";"Neutrophil degranulation";"Other glycan degradation";"Xyloglucan degradation II (exoglucanase)";"Glycosphingolipid biosynthesis - ganglio series";"HS-GAG degradation"
Medex_00010585-RA	6	Reactome: R-HSA-9640463;MetaCyc: PWY-5884;MetaCyc: PWY-7782;MetaCyc: PWY-6733;MetaCyc: PWY-7656;KEGG: 00073+1.2.1.84	"Wax biosynthesis";"Wax esters biosynthesis I";"Plasmalogen biosynthesis";"Sporopollenin precursors biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Cutin, suberine and wax biosynthesis"
Medex_00006051-RA	6	MetaCyc: PWY-6368;Reactome: R-HSA-1855204;KEGG: 00562+3.1.3.36;Reactome: R-HSA-194840;KEGG: 04070+3.1.3.36;Reactome: R-HSA-1855183	"3-phosphoinositide degradation";"Synthesis of IP3 and IP4 in the cytosol";"Inositol phosphate metabolism";"Rho GTPase cycle";"Phosphatidylinositol signaling system";"Synthesis of IP2, IP, and Ins in the cytosol"
Medex_00056038-RA	1	KEGG: 00531+3.2.1.35	"Glycosaminoglycan degradation"
Medex_00031629-RA	1	Reactome: R-HSA-1445148	"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
Medex_00059985-RA	5	Reactome: R-HSA-1912420;Reactome: R-HSA-350054;Reactome: R-HSA-1912408;Reactome: R-HSA-5083630;Reactome: R-HSA-1912399	"Pre-NOTCH Processing in Golgi";"Notch-HLH transcription pathway";"Pre-NOTCH Transcription and Translation";"Defective LFNG causes SCDO3";"Pre-NOTCH Processing in the Endoplasmic Reticulum"
Medex_00004853-RA	2	Reactome: R-HSA-1483191;Reactome: R-HSA-425366	"Synthesis of PC";"Transport of bile salts and organic acids, metal ions and amine compounds"
Medex_00022674-RA	6	KEGG: 00380+1.11.1.6;Reactome: R-HSA-3299685;Reactome: R-HSA-9615017;Reactome: R-HSA-6798695;Reactome: R-HSA-9033241;KEGG: 00630+1.11.1.6	"Tryptophan metabolism";"Detoxification of Reactive Oxygen Species";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"Neutrophil degranulation";"Peroxisomal protein import";"Glyoxylate and dicarboxylate metabolism"
Medex_00019590-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Medex_00033571-RA	4	Reactome: R-HSA-2467813;Reactome: R-HSA-2470946;Reactome: R-HSA-2468052;Reactome: R-HSA-2500257	"Separation of Sister Chromatids";"Cohesin Loading onto Chromatin";"Establishment of Sister Chromatid Cohesion";"Resolution of Sister Chromatid Cohesion"
Medex_00000282-RA	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00010586-RA	6	MetaCyc: PWY-5884;Reactome: R-HSA-9640463;KEGG: 00073+1.2.1.84;MetaCyc: PWY-7782;MetaCyc: PWY-6733;MetaCyc: PWY-7656	"Wax esters biosynthesis I";"Wax biosynthesis";"Cutin, suberine and wax biosynthesis";"Plasmalogen biosynthesis";"Sporopollenin precursors biosynthesis";"Spodoptera littoralis pheromone biosynthesis"
Medex_00071058-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Medex_00093238-RA	3	Reactome: R-HSA-5250924;Reactome: R-HSA-72165;Reactome: R-HSA-72163	"B-WICH complex positively regulates rRNA expression";"mRNA Splicing - Minor Pathway";"mRNA Splicing - Major Pathway"
Medex_00020333-RA	7	MetaCyc: PWY-1722;KEGG: 00670+6.3.4.3;MetaCyc: PWY-3841;MetaCyc: PWY-2161;Reactome: R-HSA-196757;MetaCyc: PWY-2201;KEGG: 00720+6.3.4.3	"Formate assimilation into 5,10-methylenetetrahydrofolate";"One carbon pool by folate";"Folate transformations II (plants)";"Folate polyglutamylation";"Metabolism of folate and pterines";"Folate transformations I";"Carbon fixation pathways in prokaryotes"
Medex_00019656-RA	4	Reactome: R-HSA-8866654;Reactome: R-HSA-75955;Reactome: R-HSA-112382;Reactome: R-HSA-674695	"E3 ubiquitin ligases ubiquitinate target proteins";"RNA Polymerase II Transcription Elongation";"Formation of RNA Pol II elongation complex";"RNA Polymerase II Pre-transcription Events"
Medex_00056336-RA	22	Reactome: R-HSA-195253;Reactome: R-HSA-389513;Reactome: R-HSA-432142;Reactome: R-HSA-4641262;Reactome: R-HSA-141444;Reactome: R-HSA-5358749;Reactome: R-HSA-5467348;Reactome: R-HSA-5358751;Reactome: R-HSA-6811558;Reactome: R-HSA-5673000;Reactome: R-HSA-5663220;Reactome: R-HSA-196299;Reactome: R-HSA-5358752;Reactome: R-HSA-2500257;Reactome: R-HSA-5339716;Reactome: R-HSA-5675221;Reactome: R-HSA-5358747;Reactome: R-HSA-2467813;Reactome: R-HSA-5467337;Reactome: R-HSA-5467340;Reactome: R-HSA-9648025;Reactome: R-HSA-68877	"Degradation of beta-catenin by the destruction complex";"CTLA4 inhibitory signaling";"Platelet sensitization by LDL";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"S37 mutants of beta-catenin aren't phosphorylated";"Truncations of AMER1 destabilize the destruction complex";"S45 mutants of beta-catenin aren't phosphorylated";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"RAF activation";"RHO GTPases Activate Formins";"Beta-catenin phosphorylation cascade";"T41 mutants of beta-catenin aren't phosphorylated";"Resolution of Sister Chromatid Cohesion";"Misspliced GSK3beta mutants stabilize beta-catenin";"Negative regulation of MAPK pathway";"S33 mutants of beta-catenin aren't phosphorylated";"Separation of Sister Chromatids";"APC truncation mutants have impaired AXIN binding";"AXIN missense mutants destabilize the destruction complex";"EML4 and NUDC in mitotic spindle formation";"Mitotic Prometaphase"
Medex_00062107-RA	3	MetaCyc: PWY-5129;Reactome: R-HSA-1660661;KEGG: 00600+1.14.19.17	"Sphingolipid biosynthesis (plants)";"Sphingolipid de novo biosynthesis";"Sphingolipid metabolism"
Medex_00001869-RA	2	Reactome: R-HSA-5620924;Reactome: R-HSA-5610787	"Intraflagellar transport";"Hedgehog 'off' state"
Medex_00037052-RA	5	Reactome: R-HSA-8856825;Reactome: R-HSA-3928665;Reactome: R-HSA-196025;Reactome: R-HSA-190873;Reactome: R-HSA-8856828	"Cargo recognition for clathrin-mediated endocytosis";"EPH-ephrin mediated repulsion of cells";"Formation of annular gap junctions";"Gap junction degradation";"Clathrin-mediated endocytosis"
Medex_00039015-RA	1	Reactome: R-HSA-379716	"Cytosolic tRNA aminoacylation"
Medex_00022675-RA	1	Reactome: R-HSA-606279	"Deposition of new CENPA-containing nucleosomes at the centromere"
Medex_00044836-RA	1	Reactome: R-HSA-611105	"Respiratory electron transport"
Medex_00059595-RA	6	Reactome: R-HSA-6791226;Reactome: R-HSA-429958;Reactome: R-HSA-450604;Reactome: R-HSA-450385;Reactome: R-HSA-450513;Reactome: R-HSA-380994	"Major pathway of rRNA processing in the nucleolus and cytosol";"mRNA decay by 3' to 5' exoribonuclease";"KSRP (KHSRP) binds and destabilizes mRNA";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"ATF4 activates genes in response to endoplasmic reticulum stress"
Medex_00001758-RA	1	Reactome: R-HSA-69273	"Cyclin A/B1/B2 associated events during G2/M transition"
Medex_00088221-RA	3	Reactome: R-HSA-1660514;Reactome: R-HSA-1660517;Reactome: R-HSA-1660516	"Synthesis of PIPs at the Golgi membrane";"Synthesis of PIPs at the late endosome membrane";"Synthesis of PIPs at the early endosome membrane"
Medex_00017043-RA	2	Reactome: R-HSA-8951671;Reactome: R-HSA-2032785	"RUNX3 regulates YAP1-mediated transcription";"YAP1- and WWTR1 (TAZ)-stimulated gene expression"
Medex_00003377-RA	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
Medex_00061382-RA	17	MetaCyc: PWY-8086;MetaCyc: PWY-1622;KEGG: 00710+1.1.1.37;KEGG: 00270+1.1.1.37;MetaCyc: PWY-5913;MetaCyc: PWY-6969;KEGG: 00020+1.1.1.37;MetaCyc: PWY-7383;MetaCyc: PWY-7115;KEGG: 00680+1.1.1.37;MetaCyc: PWY-5690;MetaCyc: PWY-6728;KEGG: 00630+1.1.1.37;KEGG: 00720+1.1.1.37;MetaCyc: PWY-561;KEGG: 00620+1.1.1.37;MetaCyc: PWY-5392	"(S)-lactate fermentation to propanoate, acetate and hydrogen";"Formaldehyde assimilation I (serine pathway)";"Carbon fixation in photosynthetic organisms";"Cysteine and methionine metabolism";"Partial TCA cycle (obligate autotrophs)";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Citrate cycle (TCA cycle)";"Anaerobic energy metabolism (invertebrates, cytosol)";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"Methane metabolism";"TCA cycle II (plants and fungi)";"Methylaspartate cycle";"Glyoxylate and dicarboxylate metabolism";"Carbon fixation pathways in prokaryotes";"Superpathway of glyoxylate cycle and fatty acid degradation";"Pyruvate metabolism";"Reductive TCA cycle II"
Medex_00024129-RA	17	MetaCyc: PWY-7224;MetaCyc: PWY-7184;MetaCyc: PWY-7176;MetaCyc: PWY-7187;MetaCyc: PWY-6545;MetaCyc: PWY-7222;MetaCyc: PWY-7221;KEGG: 00983+2.7.4.6;MetaCyc: PWY-7205;MetaCyc: PWY-7210;KEGG: 00240+2.7.4.6;MetaCyc: PWY-7197;MetaCyc: PWY-7220;MetaCyc: PWY-7198;MetaCyc: PWY-7226;MetaCyc: PWY-7227;KEGG: 00230+2.7.4.6	"Purine deoxyribonucleosides salvage";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"UTP and CTP de novo biosynthesis";"Pyrimidine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Guanosine deoxyribonucleotides de novo biosynthesis II";"Guanosine ribonucleotides de novo biosynthesis";"Drug metabolism - other enzymes";"CMP phosphorylation";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Pyrimidine metabolism";"Pyrimidine deoxyribonucleotide phosphorylation";"Adenosine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Guanosine deoxyribonucleotides de novo biosynthesis I";"Adenosine deoxyribonucleotides de novo biosynthesis";"Purine metabolism"
Medex_00025935-RA	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
Medex_00085242-RA	2	Reactome: R-HSA-73980;Reactome: R-HSA-749476	"RNA Polymerase III Transcription Termination";"RNA Polymerase III Abortive And Retractive Initiation"
Medex_00024206-RA	2	Reactome: R-HSA-3299685;KEGG: 00480+1.11.1.15	"Detoxification of Reactive Oxygen Species";"Glutathione metabolism"
Medex_00083656-RA	6	Reactome: R-HSA-191859;Reactome: R-HSA-72165;Reactome: R-HSA-77588;Reactome: R-HSA-72163;Reactome: R-HSA-111367;Reactome: R-HSA-73856	"snRNP Assembly";"mRNA Splicing - Minor Pathway";"SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs";"mRNA Splicing - Major Pathway";"SLBP independent Processing of Histone Pre-mRNAs";"RNA Polymerase II Transcription Termination"
Medex_00039744-RA	2	Reactome: R-HSA-1237112;Reactome: R-HSA-8950505	"Methionine salvage pathway";"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"
Medex_00011415-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Medex_00033479-RA	1	Reactome: R-HSA-4085001	"Sialic acid metabolism"
Medex_00035229-RA	3	Reactome: R-HSA-162658;Reactome: R-HSA-204005;Reactome: R-HSA-6807878	"Golgi Cisternae Pericentriolar Stack Reorganization";"COPII-mediated vesicle transport";"COPI-mediated anterograde transport"
Medex_00016064-RA	3	Reactome: R-HSA-110312;Reactome: R-HSA-5655862;Reactome: R-HSA-5656121	"Translesion synthesis by REV1";"Translesion synthesis by POLK";"Translesion synthesis by POLI"
Medex_00068507-RA	1	Reactome: R-HSA-4615885	"SUMOylation of DNA replication proteins"
Medex_00074894-RA	6	Reactome: R-HSA-72695;Reactome: R-HSA-156827;Reactome: R-HSA-72649;Reactome: R-HSA-72702;Reactome: R-HSA-72689;Reactome: R-HSA-72706	"Formation of the ternary complex, and subsequently, the 43S complex";"L13a-mediated translational silencing of Ceruloplasmin expression";"Translation initiation complex formation";"Ribosomal scanning and start codon recognition";"Formation of a pool of free 40S subunits";"GTP hydrolysis and joining of the 60S ribosomal subunit"
Medex_00012917-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00015765-RA	3	KEGG: 04660+2.7.10.2;Reactome: R-HSA-4420097;Reactome: R-HSA-391160	"T cell receptor signaling pathway";"VEGFA-VEGFR2 Pathway";"Signal regulatory protein family interactions"
Medex_00079692-RA	5	Reactome: R-HSA-75105;Reactome: R-HSA-9029558;Reactome: R-HSA-199220;Reactome: R-HSA-163765;Reactome: R-HSA-2426168	"Fatty acyl-CoA biosynthesis";"NR1H2 & NR1H3 regulate gene expression linked to lipogenesis";"Vitamin B5 (pantothenate) metabolism";"ChREBP activates metabolic gene expression";"Activation of gene expression by SREBF (SREBP)"
Medex_00033160-RA	2	Reactome: R-HSA-72165;Reactome: R-HSA-72163	"mRNA Splicing - Minor Pathway";"mRNA Splicing - Major Pathway"
Medex_00081814-RA	7	Reactome: R-HSA-5362798;Reactome: R-HSA-5658034;Reactome: R-HSA-373080;Reactome: R-HSA-5632681;Reactome: R-HSA-5358346;Reactome: R-HSA-5632684;Reactome: R-HSA-5635838	"Release of Hh-Np from the secreting cell";"HHAT G278V abrogates palmitoylation of Hh-Np";"Class B/2 (Secretin family receptors)";"Ligand-receptor interactions";"Hedgehog ligand biogenesis";"Hedgehog 'on' state";"Activation of SMO"
Medex_00091660-RA	27	Reactome: R-HSA-3232142;Reactome: R-HSA-3301854;Reactome: R-HSA-168271;Reactome: R-HSA-180910;Reactome: R-HSA-170822;Reactome: R-HSA-4570464;Reactome: R-HSA-4085377;Reactome: R-HSA-9609690;Reactome: R-HSA-4551638;Reactome: R-HSA-9610379;Reactome: R-HSA-5619107;Reactome: R-HSA-168325;Reactome: R-HSA-159236;Reactome: R-HSA-191859;Reactome: R-HSA-3108214;Reactome: R-HSA-6784531;Reactome: R-HSA-165054;Reactome: R-HSA-1169408;Reactome: R-HSA-168333;Reactome: R-HSA-180746;Reactome: R-HSA-159227;Reactome: R-HSA-159231;Reactome: R-HSA-3371453;Reactome: R-HSA-4615885;Reactome: R-HSA-159230;Reactome: R-HSA-5578749;Reactome: R-HSA-168276	"SUMOylation of ubiquitinylation proteins";"Nuclear Pore Complex (NPC) Disassembly";"Transport of Ribonucleoproteins into the Host Nucleus";"Vpr-mediated nuclear import of PICs";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"SUMOylation of RNA binding proteins";"SUMOylation of SUMOylation proteins";"HCMV Early Events";"SUMOylation of chromatin organization proteins";"HCMV Late Events";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Viral Messenger RNA Synthesis";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"snRNP Assembly";"SUMOylation of DNA damage response and repair proteins";"tRNA processing in the nucleus";"Rev-mediated nuclear export of HIV RNA";"ISG15 antiviral mechanism";"NEP/NS2 Interacts with the Cellular Export Machinery";"Nuclear import of Rev protein";"Transport of the SLBP independent Mature mRNA";"Transport of Mature mRNA Derived from an Intronless Transcript";"Regulation of HSF1-mediated heat shock response";"SUMOylation of DNA replication proteins";"Transport of the SLBP Dependant Mature mRNA";"Transcriptional regulation by small RNAs";"NS1 Mediated Effects on Host Pathways"
Medex_00043446-RA	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
Medex_00025412-RA	3	Reactome: R-HSA-74217;MetaCyc: PWY-6596;KEGG: 00230+3.5.4.6	"Purine salvage";"Adenosine nucleotides degradation I";"Purine metabolism"
Medex_00076729-RA	2	Reactome: R-HSA-6793080;Reactome: R-HSA-2151201	"rRNA modification in the mitochondrion";"Transcriptional activation of mitochondrial biogenesis"
Medex_00100586-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Medex_00043855-RA	5	Reactome: R-HSA-77595;Reactome: R-HSA-72163;Reactome: R-HSA-72187;Reactome: R-HSA-73856;Reactome: R-HSA-159231	"Processing of Intronless Pre-mRNAs";"mRNA Splicing - Major Pathway";"mRNA 3'-end processing";"RNA Polymerase II Transcription Termination";"Transport of Mature mRNA Derived from an Intronless Transcript"
Medex_00089134-RA	1	Reactome: R-HSA-2470946	"Cohesin Loading onto Chromatin"
Medex_00058619-RA	2	Reactome: R-HSA-1566948;Reactome: R-HSA-2243919	"Elastic fibre formation";"Crosslinking of collagen fibrils"
Medex_00011979-RA	5	KEGG: 00561+3.2.1.22;MetaCyc: PWY-6527;KEGG: 00052+3.2.1.22;KEGG: 00603+3.2.1.22;KEGG: 00600+3.2.1.22	"Glycerolipid metabolism";"Stachyose degradation";"Galactose metabolism";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Sphingolipid metabolism"
Medex_00042258-RA	7	MetaCyc: PWY-7511;Reactome: R-HSA-2979096;Reactome: R-HSA-2122948;Reactome: R-HSA-9013507;Reactome: R-HSA-2644606;Reactome: R-HSA-2894862;Reactome: R-HSA-2691232	"Protein ubiquitination";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Activated NOTCH1 Transmits Signal to the Nucleus";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Constitutive Signaling by NOTCH1 HD Domain Mutants"
Medex_00079215-RA	8	Reactome: R-HSA-6791461;MetaCyc: PWY-1861;KEGG: 00030+5.3.1.6;KEGG: 00051+5.3.1.6;Reactome: R-HSA-5659996;MetaCyc: PWY-5723;KEGG: 00710+5.3.1.6;Reactome: R-HSA-71336	"RPIA deficiency: failed conversion of RU5P to R5P";"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"Pentose phosphate pathway";"Fructose and mannose metabolism";"RPIA deficiency: failed conversion of R5P to RU5P";"Rubisco shunt";"Carbon fixation in photosynthetic organisms";"Pentose phosphate pathway"
Medex_00079782-RA	13	MetaCyc: PWY-7210;KEGG: 00240+1.17.4.1;KEGG: 00983+1.17.4.1;MetaCyc: PWY-7227;MetaCyc: PWY-7226;Reactome: R-HSA-499943;MetaCyc: PWY-7198;MetaCyc: PWY-6545;MetaCyc: PWY-7222;KEGG: 00230+1.17.4.1;MetaCyc: PWY-7220;KEGG: 00480+1.17.4.1;MetaCyc: PWY-7184	"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Pyrimidine metabolism";"Drug metabolism - other enzymes";"Adenosine deoxyribonucleotides de novo biosynthesis";"Guanosine deoxyribonucleotides de novo biosynthesis I";"Interconversion of nucleotide di- and triphosphates";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Guanosine deoxyribonucleotides de novo biosynthesis II";"Purine metabolism";"Adenosine deoxyribonucleotides de novo biosynthesis II";"Glutathione metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis I"
Medex_00066892-RA	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
Medex_00078358-RA	3	Reactome: R-HSA-445355;KEGG: 00230+4.6.1.2;Reactome: R-HSA-392154	"Smooth Muscle Contraction";"Purine metabolism";"Nitric oxide stimulates guanylate cyclase"
Medex_00079377-RA	4	Reactome: R-HSA-6781823;Reactome: R-HSA-8856825;Reactome: R-HSA-5696394;Reactome: R-HSA-8951664	"Formation of TC-NER Pre-Incision Complex";"Cargo recognition for clathrin-mediated endocytosis";"DNA Damage Recognition in GG-NER";"Neddylation"
Medex_00089032-RA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Medex_00093658-RA	13	MetaCyc: PWY-561;Reactome: R-HSA-71403;KEGG: 00020+4.2.1.2;KEGG: 00720+4.2.1.2;MetaCyc: PWY-5392;MetaCyc: PWY-5690;KEGG: 00620+4.2.1.2;MetaCyc: PWY-7254;MetaCyc: PWY-8086;MetaCyc: PWY-7384;MetaCyc: PWY-5913;MetaCyc: PWY-6969;MetaCyc: PWY-6728	"Superpathway of glyoxylate cycle and fatty acid degradation";"Citric acid cycle (TCA cycle)";"Citrate cycle (TCA cycle)";"Carbon fixation pathways in prokaryotes";"Reductive TCA cycle II";"TCA cycle II (plants and fungi)";"Pyruvate metabolism";"TCA cycle VII (acetate-producers)";"(S)-lactate fermentation to propanoate, acetate and hydrogen";"Anaerobic energy metabolism (invertebrates, mitochondrial)";"Partial TCA cycle (obligate autotrophs)";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Methylaspartate cycle"
Medex_00022304-RA	6	MetaCyc: PWY-622;Reactome: R-HSA-3878781;MetaCyc: PWY-7900;Reactome: R-HSA-3322077;KEGG: 00500+2.4.1.18;MetaCyc: PWY-5067	"Starch biosynthesis";"Glycogen storage disease type IV (GBE1)";"Glycogen biosynthesis III (from alpha-maltose 1-phosphate)";"Glycogen synthesis";"Starch and sucrose metabolism";"Glycogen biosynthesis II (from UDP-D-Glucose)"
Medex_00003274-RA	1	Reactome: R-HSA-426117	"Cation-coupled Chloride cotransporters"
Medex_00067764-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00025112-RA	1	Reactome: R-HSA-6809371	"Formation of the cornified envelope"
Medex_00092757-RA	15	MetaCyc: PWY-5723;MetaCyc: PWY-1042;MetaCyc: PWY-7003;MetaCyc: PWY-6142;KEGG: 00620+2.7.1.40;MetaCyc: PWY-6901;MetaCyc: PWY-2221;KEGG: 00230+2.7.1.40;Reactome: R-HSA-70171;MetaCyc: PWY-6886;KEGG: 00010+2.7.1.40;MetaCyc: PWY-5484;MetaCyc: PWY-7218;MetaCyc: PWY-7383;MetaCyc: PWY-8004	"Rubisco shunt";"Glycolysis IV (plant cytosol)";"Glycerol degradation to butanol";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Pyruvate metabolism";"Superpathway of glucose and xylose degradation";"Entner-Doudoroff pathway III (semi-phosphorylative)";"Purine metabolism";"Glycolysis";"1-butanol autotrophic biosynthesis (engineered)";"Glycolysis / Gluconeogenesis";"Glycolysis II (from fructose 6-phosphate)";"Photosynthetic 3-hydroxybutanoate biosynthesis (engineered)";"Anaerobic energy metabolism (invertebrates, cytosol)";"Entner-Doudoroff pathway I"
Medex_00074644-RA	1	Reactome: R-HSA-6802952	"Signaling by BRAF and RAF fusions"
Medex_00018830-RA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
Medex_00030640-RA	2	Reactome: R-HSA-416993;Reactome: R-HSA-202733	"Trafficking of GluR2-containing AMPA receptors";"Cell surface interactions at the vascular wall"
Medex_00081410-RA	1	KEGG: 00480+3.4.11.2	"Glutathione metabolism"
Medex_00017029-RA	6	Reactome: R-HSA-176974;Reactome: R-HSA-68962;Reactome: R-HSA-176187;Reactome: R-HSA-69052;Reactome: R-HSA-68867;Reactome: R-HSA-68949	"Unwinding of DNA";"Activation of the pre-replicative complex";"Activation of ATR in response to replication stress";"Switching of origins to a post-replicative state";"Assembly of the pre-replicative complex";"Orc1 removal from chromatin"
Medex_00045861-RA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Medex_00095796-RA	1	Reactome: R-HSA-446205	"Synthesis of GDP-mannose"
Medex_00052387-RA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
Medex_00032583-RA	2	Reactome: R-HSA-111469;Reactome: R-HSA-111457	"SMAC, XIAP-regulated apoptotic response";"Release of apoptotic factors from the mitochondria"
Medex_00006622-RA	7	KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1	"Thermogenesis";"Relaxin signaling pathway";"Human cytomegalovirus infection";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"mTOR signaling pathway";"PI3K-Akt signaling pathway"
Medex_00099992-RA	3	MetaCyc: PWY-6807;KEGG: 00511+3.2.1.51;Reactome: R-HSA-6798695	"Xyloglucan degradation II (exoglucanase)";"Other glycan degradation";"Neutrophil degranulation"
Medex_00045232-RA	3	KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16	"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
Medex_00064917-RA	58	Reactome: R-HSA-350562;Reactome: R-HSA-5678895;Reactome: R-HSA-69481;Reactome: R-HSA-174113;Reactome: R-HSA-4641257;Reactome: R-HSA-69601;Reactome: R-HSA-5362768;Reactome: R-HSA-1234176;Reactome: R-HSA-69017;Reactome: R-HSA-5676590;Reactome: R-HSA-9604323;Reactome: R-HSA-8948751;Reactome: R-HSA-68827;Reactome: R-HSA-1169091;Reactome: R-HSA-174154;Reactome: R-HSA-174184;Reactome: R-HSA-5607764;Reactome: R-HSA-8951664;Reactome: R-HSA-2871837;Reactome: R-HSA-187577;Reactome: R-HSA-174084;Reactome: R-HSA-5610783;Reactome: R-HSA-1236974;Reactome: R-HSA-8854050;Reactome: R-HSA-8939902;Reactome: R-HSA-75815;Reactome: R-HSA-195253;Reactome: R-HSA-5610785;Reactome: R-HSA-5689880;Reactome: R-HSA-5687128;Reactome: R-HSA-5668541;Reactome: R-HSA-5689603;Reactome: R-HSA-4608870;Reactome: R-HSA-5632684;Reactome: R-HSA-349425;Reactome: R-HSA-1236978;Reactome: R-HSA-180534;Reactome: R-HSA-5607761;Reactome: R-HSA-5610780;Reactome: R-HSA-8852276;Reactome: R-HSA-174178;Reactome: R-HSA-5658442;Reactome: R-HSA-8941858;Reactome: R-HSA-5358346;Reactome: R-HSA-983168;Reactome: R-HSA-202424;Reactome: R-HSA-9020702;Reactome: R-HSA-6798695;Reactome: R-HSA-4641258;Reactome: R-HSA-2467813;Reactome: R-HSA-180585;Reactome: R-HSA-5689901;Reactome: R-HSA-450408;Reactome: R-HSA-9010553;Reactome: R-HSA-68949;Reactome: R-HSA-382556;Reactome: R-HSA-211733;Reactome: R-HSA-8939236	"Regulation of ornithine decarboxylase (ODC)";"Defective CFTR causes cystic fibrosis";"G2/M Checkpoints";"SCF-beta-TrCP mediated degradation of Emi1";"Degradation of AXIN";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"CDK-mediated phosphorylation and removal of Cdc6";"NIK-->noncanonical NF-kB signaling";"Negative regulation of NOTCH4 signaling";"Regulation of PTEN stability and activity";"CDT1 association with the CDC6:ORC:origin complex";"Activation of NF-kappaB in B cells";"APC/C:Cdc20 mediated degradation of Securin";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"CLEC7A (Dectin-1) signaling";"Neddylation";"FCERI mediated NF-kB activation";"SCF(Skp2)-mediated degradation of p27/p21";"Autodegradation of Cdh1 by Cdh1:APC/C";"Degradation of GLI2 by the proteasome";"ER-Phagosome pathway";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Regulation of RUNX2 expression and activity";"Ubiquitin-dependent degradation of Cyclin D";"Degradation of beta-catenin by the destruction complex";"GLI3 is processed to GLI3R by the proteasome";"Ub-specific processing proteases";"MAPK6/MAPK4 signaling";"TNFR2 non-canonical NF-kB pathway";"UCH proteinases";"Asymmetric localization of PCP proteins";"Hedgehog 'on' state";"Autodegradation of the E3 ubiquitin ligase COP1";"Cross-presentation of soluble exogenous antigens (endosomes)";"Vpu mediated degradation of CD4";"Dectin-1 mediated noncanonical NF-kB signaling";"Degradation of GLI1 by the proteasome";"The role of GTSE1 in G2/M progression after G2 checkpoint";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Regulation of RAS by GAPs";"Regulation of RUNX3 expression and activity";"Hedgehog ligand biogenesis";"Antigen processing: Ubiquitination & Proteasome degradation";"Downstream TCR signaling";"Interleukin-1 signaling";"Neutrophil degranulation";"Degradation of DVL";"Separation of Sister Chromatids";"Vif-mediated degradation of APOBEC3G";"Metalloprotease DUBs";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Regulation of expression of SLITs and ROBOs";"Orc1 removal from chromatin";"ABC-family proteins mediated transport";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"RUNX1 regulates transcription of genes involved in differentiation of HSCs"
Medex_00000493-RA	2	Reactome: R-HSA-390471;Reactome: R-HSA-1660662	"Association of TriC/CCT with target proteins during biosynthesis";"Glycosphingolipid metabolism"
Medex_00000270-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00046047-RA	8	Reactome: R-HSA-68962;Reactome: R-HSA-113507;Reactome: R-HSA-176187;Reactome: R-HSA-68689;Reactome: R-HSA-68827;Reactome: R-HSA-68616;Reactome: R-HSA-68949;Reactome: R-HSA-68867	"Activation of the pre-replicative complex";"E2F-enabled inhibition of pre-replication complex formation";"Activation of ATR in response to replication stress";"CDC6 association with the ORC:origin complex";"CDT1 association with the CDC6:ORC:origin complex";"Assembly of the ORC complex at the origin of replication";"Orc1 removal from chromatin";"Assembly of the pre-replicative complex"
Medex_00008203-RA	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
Medex_00026505-RA	1	Reactome: R-HSA-6811438	"Intra-Golgi traffic"
Medex_00006589-RA	27	Reactome: R-HSA-5578749;Reactome: R-HSA-168276;Reactome: R-HSA-4615885;Reactome: R-HSA-159230;Reactome: R-HSA-3371453;Reactome: R-HSA-159231;Reactome: R-HSA-180746;Reactome: R-HSA-159227;Reactome: R-HSA-1169408;Reactome: R-HSA-168333;Reactome: R-HSA-165054;Reactome: R-HSA-3108214;Reactome: R-HSA-6784531;Reactome: R-HSA-168325;Reactome: R-HSA-191859;Reactome: R-HSA-159236;Reactome: R-HSA-5619107;Reactome: R-HSA-9610379;Reactome: R-HSA-4551638;Reactome: R-HSA-9609690;Reactome: R-HSA-4085377;Reactome: R-HSA-170822;Reactome: R-HSA-4570464;Reactome: R-HSA-180910;Reactome: R-HSA-168271;Reactome: R-HSA-3232142;Reactome: R-HSA-3301854	"Transcriptional regulation by small RNAs";"NS1 Mediated Effects on Host Pathways";"SUMOylation of DNA replication proteins";"Transport of the SLBP Dependant Mature mRNA";"Regulation of HSF1-mediated heat shock response";"Transport of Mature mRNA Derived from an Intronless Transcript";"Nuclear import of Rev protein";"Transport of the SLBP independent Mature mRNA";"ISG15 antiviral mechanism";"NEP/NS2 Interacts with the Cellular Export Machinery";"Rev-mediated nuclear export of HIV RNA";"SUMOylation of DNA damage response and repair proteins";"tRNA processing in the nucleus";"Viral Messenger RNA Synthesis";"snRNP Assembly";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"HCMV Late Events";"SUMOylation of chromatin organization proteins";"HCMV Early Events";"SUMOylation of SUMOylation proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"SUMOylation of RNA binding proteins";"Vpr-mediated nuclear import of PICs";"Transport of Ribonucleoproteins into the Host Nucleus";"SUMOylation of ubiquitinylation proteins";"Nuclear Pore Complex (NPC) Disassembly"
Medex_00083037-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00055289-RA	1	Reactome: R-HSA-211981	"Xenobiotics"
Medex_00009397-RA	17	MetaCyc: PWY-7224;MetaCyc: PWY-7187;MetaCyc: PWY-7176;MetaCyc: PWY-7184;MetaCyc: PWY-6545;MetaCyc: PWY-7222;MetaCyc: PWY-7205;KEGG: 00983+2.7.4.6;MetaCyc: PWY-7221;KEGG: 00240+2.7.4.6;MetaCyc: PWY-7210;MetaCyc: PWY-7220;MetaCyc: PWY-7197;KEGG: 00230+2.7.4.6;MetaCyc: PWY-7226;MetaCyc: PWY-7227;MetaCyc: PWY-7198	"Purine deoxyribonucleosides salvage";"Pyrimidine deoxyribonucleotides de novo biosynthesis II";"UTP and CTP de novo biosynthesis";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Guanosine deoxyribonucleotides de novo biosynthesis II";"CMP phosphorylation";"Drug metabolism - other enzymes";"Guanosine ribonucleotides de novo biosynthesis";"Pyrimidine metabolism";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Adenosine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotide phosphorylation";"Purine metabolism";"Guanosine deoxyribonucleotides de novo biosynthesis I";"Adenosine deoxyribonucleotides de novo biosynthesis";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV"
Medex_00020562-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Medex_00074963-RA	1	Reactome: R-HSA-8951664	"Neddylation"
Medex_00019817-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Medex_00051083-RA	2	Reactome: R-HSA-196780;Reactome: R-HSA-3371599	"Biotin transport and metabolism";"Defective HLCS causes multiple carboxylase deficiency"
Medex_00075215-RA	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
Medex_00041318-RA	6	Reactome: R-HSA-69052;Reactome: R-HSA-68867;Reactome: R-HSA-68949;Reactome: R-HSA-68962;Reactome: R-HSA-176974;Reactome: R-HSA-176187	"Switching of origins to a post-replicative state";"Assembly of the pre-replicative complex";"Orc1 removal from chromatin";"Activation of the pre-replicative complex";"Unwinding of DNA";"Activation of ATR in response to replication stress"
Medex_00077162-RA	3	MetaCyc: PWY-8106;MetaCyc: PWY-6700;Reactome: R-HSA-6782315	"Queuosine biosynthesis III (queuosine salvage)";"Queuosine biosynthesis I (de novo)";"tRNA modification in the nucleus and cytosol"
Medex_00014037-RA	2	KEGG: 00511+3.2.1.24;Reactome: R-HSA-8853383	"Other glycan degradation";"Lysosomal oligosaccharide catabolism"
Medex_00080032-RA	2	Reactome: R-HSA-1989781;Reactome: R-HSA-381340	"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation"
Medex_00010416-RA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
Medex_00057621-RA	1	Reactome: R-HSA-5578775	"Ion homeostasis"
Medex_00034599-RA	1	Reactome: R-HSA-1445148	"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
Medex_00019253-RA	1	Reactome: R-HSA-8951664	"Neddylation"
Medex_00076962-RA	2	Reactome: R-HSA-204174;Reactome: R-HSA-5362517	"Regulation of pyruvate dehydrogenase (PDH) complex";"Signaling by Retinoic Acid"
Medex_00097781-RA	2	Reactome: R-HSA-5628897;Reactome: R-HSA-611105	"TP53 Regulates Metabolic Genes";"Respiratory electron transport"
Medex_00059854-RA	1	Reactome: R-HSA-6811440	"Retrograde transport at the Trans-Golgi-Network"
Medex_00051433-RA	3	Reactome: R-HSA-2029482;Reactome: R-HSA-202433;Reactome: R-HSA-5663213	"Regulation of actin dynamics for phagocytic cup formation";"Generation of second messenger molecules";"RHO GTPases Activate WASPs and WAVEs"
Medex_00055695-RA	12	Reactome: R-HSA-75955;Reactome: R-HSA-167238;Reactome: R-HSA-6796648;Reactome: R-HSA-112382;Reactome: R-HSA-167246;Reactome: R-HSA-6804756;Reactome: R-HSA-167200;Reactome: R-HSA-167290;Reactome: R-HSA-674695;Reactome: R-HSA-167152;Reactome: R-HSA-167287;Reactome: R-HSA-167243	"RNA Polymerase II Transcription Elongation";"Pausing and recovery of Tat-mediated HIV elongation";"TP53 Regulates Transcription of DNA Repair Genes";"Formation of RNA Pol II elongation complex";"Tat-mediated elongation of the HIV-1 transcript";"Regulation of TP53 Activity through Phosphorylation";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Pausing and recovery of HIV elongation";"RNA Polymerase II Pre-transcription Events";"Formation of HIV elongation complex in the absence of HIV Tat";"HIV elongation arrest and recovery";"Tat-mediated HIV elongation arrest and recovery"
Medex_00072539-RA	4	Reactome: R-HSA-5696394;Reactome: R-HSA-6781823;Reactome: R-HSA-8856825;Reactome: R-HSA-8951664	"DNA Damage Recognition in GG-NER";"Formation of TC-NER Pre-Incision Complex";"Cargo recognition for clathrin-mediated endocytosis";"Neddylation"
Medex_00017872-RA	1	Reactome: R-HSA-8951664	"Neddylation"
Medex_00009499-RA	5	Reactome: R-HSA-983170;Reactome: R-HSA-5694530;Reactome: R-HSA-1655829;Reactome: R-HSA-204005;Reactome: R-HSA-2132295	"Antigen Presentation: Folding, assembly and peptide loading of class I MHC";"Cargo concentration in the ER";"Regulation of cholesterol biosynthesis by SREBP (SREBF)";"COPII-mediated vesicle transport";"MHC class II antigen presentation"
Medex_00038753-RA	1	KEGG: 00480+3.4.11.1	"Glutathione metabolism"
Medex_00038158-RA	4	Reactome: R-HSA-964975;KEGG: 00750+1.4.3.5;MetaCyc: PWY-7282;MetaCyc: PWY-7204	"Vitamins B6 activation to pyridoxal phosphate";"Vitamin B6 metabolism";"4-amino-2-methyl-5-phosphomethylpyrimidine biosynthesis";"Pyridoxal 5'-phosphate salvage II (plants)"
Medex_00025042-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00079102-RA	2	Reactome: R-HSA-6798695;Reactome: R-HSA-2022377	"Neutrophil degranulation";"Metabolism of Angiotensinogen to Angiotensins"
Medex_00028734-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00026029-RA	1	KEGG: 00860+4.4.1.17	"Porphyrin and chlorophyll metabolism"
Medex_00051685-RA	13	Reactome: R-HSA-72706;Reactome: R-HSA-975956;Reactome: R-HSA-72689;Reactome: R-HSA-72764;Reactome: R-HSA-2408557;Reactome: R-HSA-6791226;Reactome: R-HSA-975957;Reactome: R-HSA-192823;Reactome: R-HSA-1799339;Reactome: R-HSA-156902;Reactome: R-HSA-9633012;Reactome: R-HSA-9010553;Reactome: R-HSA-156827	"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Formation of a pool of free 40S subunits";"Eukaryotic Translation Termination";"Selenocysteine synthesis";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Viral mRNA Translation";"SRP-dependent cotranslational protein targeting to membrane";"Peptide chain elongation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression"
Medex_00022978-RA	1	Reactome: R-HSA-209968	"Thyroxine biosynthesis"
Medex_00025043-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00046338-RA	2	Reactome: R-HSA-3065678;Reactome: R-HSA-3065676	"SUMO is transferred from E1 to E2 (UBE2I, UBC9)";"SUMO is conjugated to E1 (UBA2:SAE1)"
Medex_00094214-RA	2	Reactome: R-HSA-390471;Reactome: R-HSA-1660662	"Association of TriC/CCT with target proteins during biosynthesis";"Glycosphingolipid metabolism"
Medex_00054537-RA	1	Reactome: R-HSA-6798163	"Choline catabolism"
Medex_00081477-RA	2	Reactome: R-HSA-3214858;Reactome: R-HSA-8939243	"RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"
Medex_00023123-RA	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
Medex_00026041-RA	3	MetaCyc: PWY-6483;MetaCyc: PWY-7119;KEGG: 00600+3.5.1.23	"Ceramide degradation (generic)";"Ceramide and sphingolipid recycling and degradation (yeast)";"Sphingolipid metabolism"
Medex_00056036-RA	1	KEGG: 00531+3.2.1.35	"Glycosaminoglycan degradation"
Medex_00071281-RA	4	Reactome: R-HSA-9010553;Reactome: R-HSA-72764;Reactome: R-HSA-975957;Reactome: R-HSA-975956	"Regulation of expression of SLITs and ROBOs";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"
Medex_00088267-RA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
Medex_00072682-RA	1	Reactome: R-HSA-8963693	"Aspartate and asparagine metabolism"
Medex_00042493-RA	2	Reactome: R-HSA-8876198;Reactome: R-HSA-204005	"RAB GEFs exchange GTP for GDP on RABs";"COPII-mediated vesicle transport"
Medex_00031399-RA	1	KEGG: 00760+2.3.1.286	"Nicotinate and nicotinamide metabolism"
Medex_00047649-RA	3	Reactome: R-HSA-72187;Reactome: R-HSA-73856;Reactome: R-HSA-159236	"mRNA 3'-end processing";"RNA Polymerase II Transcription Termination";"Transport of Mature mRNA derived from an Intron-Containing Transcript"
Medex_00044337-RA	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
Medex_00048316-RA	1	Reactome: R-HSA-912446	"Meiotic recombination"
Medex_00086335-RA	1	Reactome: R-HSA-4615885	"SUMOylation of DNA replication proteins"
Medex_00065138-RA	3	KEGG: 00970+6.1.1.4;Reactome: R-HSA-379716;Reactome: R-HSA-2408522	"Aminoacyl-tRNA biosynthesis";"Cytosolic tRNA aminoacylation";"Selenoamino acid metabolism"
Medex_00033880-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Medex_00090038-RA	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
Medex_00037094-RA	4	Reactome: R-HSA-73856;Reactome: R-HSA-72187;Reactome: R-HSA-72163;Reactome: R-HSA-159236	"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing";"mRNA Splicing - Major Pathway";"Transport of Mature mRNA derived from an Intron-Containing Transcript"
Medex_00036732-RA	6	Reactome: R-HSA-6804759;Reactome: R-HSA-6803211;Reactome: R-HSA-6803204;Reactome: R-HSA-139915;Reactome: R-HSA-6803205;Reactome: R-HSA-6803207	"Regulation of TP53 Activity through Association with Co-factors";"TP53 Regulates Transcription of Death Receptors and Ligands";"TP53 Regulates Transcription of Genes Involved in Cytochrome C Release";"Activation of PUMA and translocation to mitochondria";"TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain";"TP53 Regulates Transcription of Caspase Activators and Caspases"
Medex_00015909-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Medex_00081178-RA	13	Reactome: R-HSA-380972;Reactome: R-HSA-3371571;Reactome: R-HSA-166208;Reactome: R-HSA-165159;Reactome: R-HSA-9639288;Reactome: R-HSA-1632852;Reactome: R-HSA-1257604;Reactome: R-HSA-389357;Reactome: R-HSA-5628897;Reactome: R-HSA-5674400;Reactome: R-HSA-5218920;Reactome: R-HSA-6804757;Reactome: R-HSA-8943724	"Energy dependent regulation of mTOR by LKB1-AMPK";"HSF1-dependent transactivation";"mTORC1-mediated signalling";"mTOR signalling";"Amino acids regulate mTORC1";"Macroautophagy";"PIP3 activates AKT signaling";"CD28 dependent PI3K/Akt signaling";"TP53 Regulates Metabolic Genes";"Constitutive Signaling by AKT1 E17K in Cancer";"VEGFR2 mediated vascular permeability";"Regulation of TP53 Degradation";"Regulation of PTEN gene transcription"
Medex_00080790-RA	1	Reactome: R-HSA-5658442	"Regulation of RAS by GAPs"
Medex_00002712-RA	9	Reactome: R-HSA-6782135;Reactome: R-HSA-110314;Reactome: R-HSA-5696400;Reactome: R-HSA-8951664;Reactome: R-HSA-6781823;Reactome: R-HSA-5696395;Reactome: R-HSA-6781827;Reactome: R-HSA-5696394;Reactome: R-HSA-6782210	"Dual incision in TC-NER";"Recognition of DNA damage by PCNA-containing replication complex";"Dual Incision in GG-NER";"Neddylation";"Formation of TC-NER Pre-Incision Complex";"Formation of Incision Complex in GG-NER";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"DNA Damage Recognition in GG-NER";"Gap-filling DNA repair synthesis and ligation in TC-NER"
Medex_00039220-RA	1	Reactome: R-HSA-1474228	"Degradation of the extracellular matrix"
Medex_00005312-RA	3	Reactome: R-HSA-9018519;Reactome: R-HSA-381340;Reactome: R-HSA-1989781	"Estrogen-dependent gene expression";"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression"
Medex_00070705-RA	3	Reactome: R-HSA-264876;Reactome: R-HSA-5620916;Reactome: R-HSA-1445148	"Insulin processing";"VxPx cargo-targeting to cilium";"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
Medex_00020377-RA	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
Medex_00072331-RA	2	Reactome: R-HSA-6798695;Reactome: R-HSA-1660662	"Neutrophil degranulation";"Glycosphingolipid metabolism"
Medex_00053662-RA	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
Medex_00069658-RA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
Medex_00030164-RA	7	KEGG: 00020+1.2.4.1;Reactome: R-HSA-389661;Reactome: R-HSA-5362517;KEGG: 00010+1.2.4.1;KEGG: 00620+1.2.4.1;Reactome: R-HSA-204174;Reactome: R-HSA-70268	"Citrate cycle (TCA cycle)";"Glyoxylate metabolism and glycine degradation";"Signaling by Retinoic Acid";"Glycolysis / Gluconeogenesis";"Pyruvate metabolism";"Regulation of pyruvate dehydrogenase (PDH) complex";"Pyruvate metabolism"
Medex_00048051-RA	2	KEGG: 00030+2.7.6.1;KEGG: 00230+2.7.6.1	"Pentose phosphate pathway";"Purine metabolism"
Medex_00101098-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00033077-RA	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
Medex_00049357-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Medex_00036679-RA	1	Reactome: R-HSA-6790901	"rRNA modification in the nucleus and cytosol"
Medex_00036839-RA	4	Reactome: R-HSA-156581;MetaCyc: PWY-5041;MetaCyc: PWY-5912;KEGG: 00270+2.5.1.6	"Methylation";"S-adenosyl-L-methionine cycle II";"2'-deoxymugineic acid phytosiderophore biosynthesis";"Cysteine and methionine metabolism"
Medex_00024574-RA	7	MetaCyc: PWY-7445;MetaCyc: PWY-7214;MetaCyc: PWY-5466;KEGG: 00940+1.11.1.7;MetaCyc: PWY-6824;MetaCyc: PWY-5461;MetaCyc: PWY-5469	"Luteolin triglucuronide degradation";"Baicalein degradation (hydrogen peroxide detoxification)";"Matairesinol biosynthesis";"Phenylpropanoid biosynthesis";"Justicidin B biosynthesis";"Betanidin degradation";"Sesamin biosynthesis"
Medex_00099011-RA	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276	"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination"
Medex_00020705-RA	2	KEGG: 00561+2.7.1.30;MetaCyc: PWY-4261	"Glycerolipid metabolism";"Glycerol degradation I"
Medex_00020613-RA	1	Reactome: R-HSA-1221632	"Meiotic synapsis"
Medex_00047064-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Medex_00013313-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Medex_00004076-RA	1	KEGG: 00970+6.1.1.3	"Aminoacyl-tRNA biosynthesis"
Medex_00093880-RA	2	Reactome: R-HSA-5601884;Reactome: R-HSA-1221632	"PIWI-interacting RNA (piRNA) biogenesis";"Meiotic synapsis"
Medex_00084699-RA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Medex_00060309-RA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
Medex_00029264-RA	1	Reactome: R-HSA-5358493	"Synthesis of diphthamide-EEF2"
Medex_00040987-RA	1	Reactome: R-HSA-373753	"Nephrin family interactions"
Medex_00064442-RA	3	Reactome: R-HSA-196807;Reactome: R-HSA-74259;Reactome: R-HSA-73621	"Nicotinate metabolism";"Purine catabolism";"Pyrimidine catabolism"
Medex_00008903-RA	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5419276;Reactome: R-HSA-5389840	"Mitochondrial translation initiation";"Mitochondrial translation termination";"Mitochondrial translation elongation"
Medex_00089780-RA	3	Reactome: R-HSA-196807;Reactome: R-HSA-73621;Reactome: R-HSA-74259	"Nicotinate metabolism";"Pyrimidine catabolism";"Purine catabolism"
Medex_00042297-RA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
Medex_00089310-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Medex_00002633-RA	6	KEGG: 00930+3.1.1.17;KEGG: 00053+3.1.1.17;MetaCyc: PWY-7165;MetaCyc: PWY-5530;KEGG: 00030+3.1.1.17;MetaCyc: PWY-2221	"Caprolactam degradation";"Ascorbate and aldarate metabolism";"L-ascorbate biosynthesis VI (engineered pathway)";"Sorbitol biosynthesis II";"Pentose phosphate pathway";"Entner-Doudoroff pathway III (semi-phosphorylative)"
Medex_00009819-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00010712-RA	9	Reactome: R-HSA-3656253;Reactome: R-HSA-4420332;Reactome: R-HSA-3656237;Reactome: R-HSA-1971475;Reactome: R-HSA-2022928;Reactome: R-HSA-2024096;Reactome: R-HSA-3560783;Reactome: R-HSA-3560801;Reactome: R-HSA-975634	"Defective EXT1 causes exostoses 1, TRPS2 and CHDS";"Defective B3GALT6 causes EDSP2 and SEMDJL1";"Defective EXT2 causes exostoses 2";"A tetrasaccharide linker sequence is required for GAG synthesis";"HS-GAG biosynthesis";"HS-GAG degradation";"Defective B4GALT7 causes EDS, progeroid type";"Defective B3GAT3 causes JDSSDHD";"Retinoid metabolism and transport"
Medex_00064721-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Medex_00044176-RA	2	Reactome: R-HSA-611105;Reactome: R-HSA-5628897	"Respiratory electron transport";"TP53 Regulates Metabolic Genes"
Medex_00013323-RA	56	Reactome: R-HSA-5610785;Reactome: R-HSA-5689880;Reactome: R-HSA-4608870;Reactome: R-HSA-5689603;Reactome: R-HSA-5668541;Reactome: R-HSA-5687128;Reactome: R-HSA-75815;Reactome: R-HSA-8939902;Reactome: R-HSA-195253;Reactome: R-HSA-5610780;Reactome: R-HSA-8852276;Reactome: R-HSA-5607761;Reactome: R-HSA-174178;Reactome: R-HSA-5632684;Reactome: R-HSA-180534;Reactome: R-HSA-349425;Reactome: R-HSA-1236978;Reactome: R-HSA-9020702;Reactome: R-HSA-8941858;Reactome: R-HSA-5358346;Reactome: R-HSA-5658442;Reactome: R-HSA-202424;Reactome: R-HSA-983168;Reactome: R-HSA-382556;Reactome: R-HSA-68949;Reactome: R-HSA-8939236;Reactome: R-HSA-211733;Reactome: R-HSA-9010553;Reactome: R-HSA-2467813;Reactome: R-HSA-4641258;Reactome: R-HSA-450408;Reactome: R-HSA-180585;Reactome: R-HSA-5676590;Reactome: R-HSA-5362768;Reactome: R-HSA-69017;Reactome: R-HSA-1234176;Reactome: R-HSA-69601;Reactome: R-HSA-68827;Reactome: R-HSA-8948751;Reactome: R-HSA-9604323;Reactome: R-HSA-350562;Reactome: R-HSA-5678895;Reactome: R-HSA-69481;Reactome: R-HSA-4641257;Reactome: R-HSA-174113;Reactome: R-HSA-2871837;Reactome: R-HSA-8951664;Reactome: R-HSA-174154;Reactome: R-HSA-1169091;Reactome: R-HSA-174184;Reactome: R-HSA-5607764;Reactome: R-HSA-174084;Reactome: R-HSA-187577;Reactome: R-HSA-5610783;Reactome: R-HSA-8854050;Reactome: R-HSA-1236974	"GLI3 is processed to GLI3R by the proteasome";"Ub-specific processing proteases";"Asymmetric localization of PCP proteins";"UCH proteinases";"TNFR2 non-canonical NF-kB pathway";"MAPK6/MAPK4 signaling";"Ubiquitin-dependent degradation of Cyclin D";"Regulation of RUNX2 expression and activity";"Degradation of beta-catenin by the destruction complex";"Degradation of GLI1 by the proteasome";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Dectin-1 mediated noncanonical NF-kB signaling";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Hedgehog 'on' state";"Vpu mediated degradation of CD4";"Autodegradation of the E3 ubiquitin ligase COP1";"Cross-presentation of soluble exogenous antigens (endosomes)";"Interleukin-1 signaling";"Regulation of RUNX3 expression and activity";"Hedgehog ligand biogenesis";"Regulation of RAS by GAPs";"Downstream TCR signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"ABC-family proteins mediated transport";"Orc1 removal from chromatin";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Regulation of expression of SLITs and ROBOs";"Separation of Sister Chromatids";"Degradation of DVL";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Vif-mediated degradation of APOBEC3G";"NIK-->noncanonical NF-kB signaling";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"CDK-mediated phosphorylation and removal of Cdc6";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"CDT1 association with the CDC6:ORC:origin complex";"Regulation of PTEN stability and activity";"Negative regulation of NOTCH4 signaling";"Regulation of ornithine decarboxylase (ODC)";"Defective CFTR causes cystic fibrosis";"G2/M Checkpoints";"Degradation of AXIN";"SCF-beta-TrCP mediated degradation of Emi1";"FCERI mediated NF-kB activation";"Neddylation";"APC/C:Cdc20 mediated degradation of Securin";"Activation of NF-kappaB in B cells";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"CLEC7A (Dectin-1) signaling";"Autodegradation of Cdh1 by Cdh1:APC/C";"SCF(Skp2)-mediated degradation of p27/p21";"Degradation of GLI2 by the proteasome";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"ER-Phagosome pathway"
Medex_00036027-RA	57	Reactome: R-HSA-195253;Reactome: R-HSA-75815;Reactome: R-HSA-8939902;Reactome: R-HSA-4608870;Reactome: R-HSA-5687128;Reactome: R-HSA-5668541;Reactome: R-HSA-5689603;Reactome: R-HSA-5610785;Reactome: R-HSA-5689880;Reactome: R-HSA-180534;Reactome: R-HSA-1236978;Reactome: R-HSA-349425;Reactome: R-HSA-5632684;Reactome: R-HSA-174178;Reactome: R-HSA-5610780;Reactome: R-HSA-8852276;Reactome: R-HSA-5607761;Reactome: R-HSA-202424;Reactome: R-HSA-983168;Reactome: R-HSA-5358346;Reactome: R-HSA-8941858;Reactome: R-HSA-5658442;Reactome: R-HSA-6798695;Reactome: R-HSA-9020702;Reactome: R-HSA-450408;Reactome: R-HSA-180585;Reactome: R-HSA-2467813;Reactome: R-HSA-4641258;Reactome: R-HSA-8939236;Reactome: R-HSA-211733;Reactome: R-HSA-382556;Reactome: R-HSA-68949;Reactome: R-HSA-9010553;Reactome: R-HSA-4641257;Reactome: R-HSA-174113;Reactome: R-HSA-5678895;Reactome: R-HSA-69481;Reactome: R-HSA-350562;Reactome: R-HSA-8948751;Reactome: R-HSA-9604323;Reactome: R-HSA-68827;Reactome: R-HSA-5676590;Reactome: R-HSA-69601;Reactome: R-HSA-1234176;Reactome: R-HSA-5362768;Reactome: R-HSA-69017;Reactome: R-HSA-5607764;Reactome: R-HSA-174184;Reactome: R-HSA-174154;Reactome: R-HSA-1169091;Reactome: R-HSA-2871837;Reactome: R-HSA-8951664;Reactome: R-HSA-174084;Reactome: R-HSA-187577;Reactome: R-HSA-8854050;Reactome: R-HSA-1236974;Reactome: R-HSA-5610783	"Degradation of beta-catenin by the destruction complex";"Ubiquitin-dependent degradation of Cyclin D";"Regulation of RUNX2 expression and activity";"Asymmetric localization of PCP proteins";"MAPK6/MAPK4 signaling";"TNFR2 non-canonical NF-kB pathway";"UCH proteinases";"GLI3 is processed to GLI3R by the proteasome";"Ub-specific processing proteases";"Vpu mediated degradation of CD4";"Cross-presentation of soluble exogenous antigens (endosomes)";"Autodegradation of the E3 ubiquitin ligase COP1";"Hedgehog 'on' state";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Degradation of GLI1 by the proteasome";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Dectin-1 mediated noncanonical NF-kB signaling";"Downstream TCR signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Hedgehog ligand biogenesis";"Regulation of RUNX3 expression and activity";"Regulation of RAS by GAPs";"Neutrophil degranulation";"Interleukin-1 signaling";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Vif-mediated degradation of APOBEC3G";"Separation of Sister Chromatids";"Degradation of DVL";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"ABC-family proteins mediated transport";"Orc1 removal from chromatin";"Regulation of expression of SLITs and ROBOs";"Degradation of AXIN";"SCF-beta-TrCP mediated degradation of Emi1";"Defective CFTR causes cystic fibrosis";"G2/M Checkpoints";"Regulation of ornithine decarboxylase (ODC)";"Regulation of PTEN stability and activity";"Negative regulation of NOTCH4 signaling";"CDT1 association with the CDC6:ORC:origin complex";"NIK-->noncanonical NF-kB signaling";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"CDK-mediated phosphorylation and removal of Cdc6";"CLEC7A (Dectin-1) signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"APC/C:Cdc20 mediated degradation of Securin";"Activation of NF-kappaB in B cells";"FCERI mediated NF-kB activation";"Neddylation";"Autodegradation of Cdh1 by Cdh1:APC/C";"SCF(Skp2)-mediated degradation of p27/p21";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"ER-Phagosome pathway";"Degradation of GLI2 by the proteasome"
Medex_00062861-RA	18	MetaCyc: PWY-7383;MetaCyc: PWY-7115;MetaCyc: PWY-6638;MetaCyc: PWY-6642;KEGG: 00270+2.6.1.1;KEGG: 00220+2.6.1.1;KEGG: 00350+2.6.1.1;KEGG: 00360+2.6.1.1;MetaCyc: PWY-6643;MetaCyc: PWY-5913;MetaCyc: PWY-7117;KEGG: 00710+2.6.1.1;KEGG: 00250+2.6.1.1;KEGG: 00950+2.6.1.1;KEGG: 00330+2.6.1.1;KEGG: 00960+2.6.1.1;KEGG: 00400+2.6.1.1;KEGG: 00401+2.6.1.1	"Anaerobic energy metabolism (invertebrates, cytosol)";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"Sulfolactate degradation III";"(R)-cysteate degradation";"Cysteine and methionine metabolism";"Arginine biosynthesis";"Tyrosine metabolism";"Phenylalanine metabolism";"Coenzyme M biosynthesis II";"Partial TCA cycle (obligate autotrophs)";"C4 photosynthetic carbon assimilation cycle, PEPCK type";"Carbon fixation in photosynthetic organisms";"Alanine, aspartate and glutamate metabolism";"Isoquinoline alkaloid biosynthesis";"Arginine and proline metabolism";"Tropane, piperidine and pyridine alkaloid biosynthesis";"Phenylalanine, tyrosine and tryptophan biosynthesis";"Novobiocin biosynthesis"
Medex_00022372-RA	2	Reactome: R-HSA-5610787;Reactome: R-HSA-5620924	"Hedgehog 'off' state";"Intraflagellar transport"
Medex_00001445-RA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
Medex_00073817-RA	2	Reactome: R-HSA-5578775;Reactome: R-HSA-2672351	"Ion homeostasis";"Stimuli-sensing channels"
Medex_00047630-RA	1	Reactome: R-HSA-176974	"Unwinding of DNA"
Medex_00002833-RA	1	Reactome: R-HSA-71403	"Citric acid cycle (TCA cycle)"
Medex_00081398-RA	1	Reactome: R-HSA-2564830	"Cytosolic iron-sulfur cluster assembly"
Medex_00079857-RA	1	Reactome: R-HSA-3214858	"RMTs methylate histone arginines"
Medex_00066733-RA	6	MetaCyc: PWY-6733;MetaCyc: PWY-7782;MetaCyc: PWY-7656;KEGG: 00073+1.2.1.84;Reactome: R-HSA-9640463;MetaCyc: PWY-5884	"Sporopollenin precursors biosynthesis";"Plasmalogen biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax biosynthesis";"Wax esters biosynthesis I"
Medex_00071595-RA	7	Reactome: R-HSA-9010553;Reactome: R-HSA-5083629;Reactome: R-HSA-5173105;Reactome: R-HSA-5083633;Reactome: R-HSA-5083628;Reactome: R-HSA-3000178;Reactome: R-HSA-3000171	"Regulation of expression of SLITs and ROBOs";"Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2";"O-linked glycosylation";"Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1";"Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3";"ECM proteoglycans";"Non-integrin membrane-ECM interactions"
Medex_00047900-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00018882-RA	1	Reactome: R-HSA-216083	"Integrin cell surface interactions"
Medex_00066834-RA	18	KEGG: 00020+6.2.1.5;MetaCyc: PWY-5172;Reactome: R-HSA-6798695;KEGG: 00640+6.2.1.5;Reactome: R-HSA-163765;KEGG: 00720+6.2.1.5;MetaCyc: PWY-7384;KEGG: 00020+2.3.3.8;KEGG: 00720+2.3.3.8;MetaCyc: PWY-5913;MetaCyc: PWY-6969;MetaCyc: PWY-5537;MetaCyc: PWY-5538;MetaCyc: PWY-5392;Reactome: R-HSA-75105;MetaCyc: PWY-5690;KEGG: 00660+6.2.1.5;MetaCyc: PWY-6728	"Citrate cycle (TCA cycle)";"Acetyl-coa biosynthesis III (from citrate)";"Neutrophil degranulation";"Propanoate metabolism";"ChREBP activates metabolic gene expression";"Carbon fixation pathways in prokaryotes";"Anaerobic energy metabolism (invertebrates, mitochondrial)";"Citrate cycle (TCA cycle)";"Carbon fixation pathways in prokaryotes";"Partial TCA cycle (obligate autotrophs)";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Pyruvate fermentation to acetate V";"Pyruvate fermentation to acetate VI";"Reductive TCA cycle II";"Fatty acyl-CoA biosynthesis";"TCA cycle II (plants and fungi)";"C5-Branched dibasic acid metabolism";"Methylaspartate cycle"
Medex_00044897-RA	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
Medex_00050106-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Medex_00054898-RA	1	KEGG: 00230+3.6.1.29	"Purine metabolism"
Medex_00067990-RA	3	Reactome: R-HSA-6811438;Reactome: R-HSA-6811440;Reactome: R-HSA-8876198	"Intra-Golgi traffic";"Retrograde transport at the Trans-Golgi-Network";"RAB GEFs exchange GTP for GDP on RABs"
Medex_00017701-RA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
Medex_00047230-RA	1	Reactome: R-HSA-1614517	"Sulfide oxidation to sulfate"
Medex_00018179-RA	1	Reactome: R-HSA-380320	"Recruitment of NuMA to mitotic centrosomes"
Medex_00017971-RA	5	Reactome: R-HSA-389960;Reactome: R-HSA-390450;Reactome: R-HSA-6814122;Reactome: R-HSA-389957;Reactome: R-HSA-390471	"Formation of tubulin folding intermediates by CCT/TriC";"Folding of actin by CCT/TriC";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"Prefoldin mediated transfer of substrate to CCT/TriC";"Association of TriC/CCT with target proteins during biosynthesis"
Medex_00026028-RA	1	KEGG: 00970+6.3.5.7	"Aminoacyl-tRNA biosynthesis"
Medex_00007504-RA	1	KEGG: 00230+4.6.1.2	"Purine metabolism"
Medex_00094139-RA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
Medex_00006639-RA	1	KEGG: 00480+3.4.11.2	"Glutathione metabolism"
Medex_00102028-RA	1	Reactome: R-HSA-8949664	"Processing of SMDT1"
Medex_00065644-RA	26	Reactome: R-HSA-5626467;Reactome: R-HSA-2132295;Reactome: R-HSA-6807878;Reactome: R-HSA-190840;Reactome: R-HSA-190861;Reactome: R-HSA-9619483;Reactome: R-HSA-437239;Reactome: R-HSA-9609690;Reactome: R-HSA-6811436;Reactome: R-HSA-8955332;Reactome: R-HSA-8852276;Reactome: R-HSA-983189;Reactome: R-HSA-9609736;Reactome: R-HSA-2500257;Reactome: R-HSA-380320;Reactome: R-HSA-3371497;Reactome: R-HSA-5663220;Reactome: R-HSA-389960;Reactome: R-HSA-1445148;Reactome: R-HSA-68877;Reactome: R-HSA-9648025;Reactome: R-HSA-6811434;Reactome: R-HSA-389977;Reactome: R-HSA-2467813;Reactome: R-HSA-9646399;Reactome: R-HSA-5617833	"RHO GTPases activate IQGAPs";"MHC class II antigen presentation";"COPI-mediated anterograde transport";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Gap junction assembly";"Activation of AMPK downstream of NMDARs";"Recycling pathway of L1";"HCMV Early Events";"COPI-independent Golgi-to-ER retrograde traffic";"Carboxyterminal post-translational modifications of tubulin";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Kinesins";"Assembly and cell surface presentation of NMDA receptors";"Resolution of Sister Chromatid Cohesion";"Recruitment of NuMA to mitotic centrosomes";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"RHO GTPases Activate Formins";"Formation of tubulin folding intermediates by CCT/TriC";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Mitotic Prometaphase";"EML4 and NUDC in mitotic spindle formation";"COPI-dependent Golgi-to-ER retrograde traffic";"Post-chaperonin tubulin folding pathway";"Separation of Sister Chromatids";"Aggrephagy";"Cilium Assembly"
Medex_00007794-RA	25	Reactome: R-HSA-8877330;Reactome: R-HSA-8939242;Reactome: R-HSA-8878166;Reactome: R-HSA-8951936;Reactome: R-HSA-8939245;Reactome: R-HSA-8939236;Reactome: R-HSA-8939243;Reactome: R-HSA-8940973;Reactome: R-HSA-8941858;Reactome: R-HSA-8951911;Reactome: R-HSA-9018519;Reactome: R-HSA-8939247;Reactome: R-HSA-8936459;Reactome: R-HSA-8941284;Reactome: R-HSA-8939246;Reactome: R-HSA-8931987;Reactome: R-HSA-8935964;Reactome: R-HSA-8949275;Reactome: R-HSA-8941326;Reactome: R-HSA-8939256;Reactome: R-HSA-8941333;Reactome: R-HSA-9616222;Reactome: R-HSA-8939902;Reactome: R-HSA-8934593;Reactome: R-HSA-8941332	"RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)";"RUNX1 regulates transcription of genes involved in differentiation of keratinocytes";"Transcriptional regulation by RUNX2";"RUNX3 regulates p14-ARF";"RUNX1 regulates transcription of genes involved in BCR signaling";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RUNX2 regulates osteoblast differentiation";"Regulation of RUNX3 expression and activity";"RUNX3 regulates RUNX1-mediated transcription";"Estrogen-dependent gene expression";"RUNX1 regulates transcription of genes involved in interleukin signaling";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"RUNX2 regulates chondrocyte maturation";"RUNX1 regulates transcription of genes involved in differentiation of myeloid cells";"RUNX1 regulates estrogen receptor mediated transcription";"RUNX1 regulates expression of components of tight junctions";"RUNX3 Regulates Immune Response and Cell Migration";"RUNX2 regulates bone development";"RUNX1 regulates transcription of genes involved in WNT signaling";"RUNX2 regulates genes involved in differentiation of myeloid cells";"Transcriptional regulation of granulopoiesis";"Regulation of RUNX2 expression and activity";"Regulation of RUNX1 Expression and Activity";"RUNX2 regulates genes involved in cell migration"
Medex_00038436-RA	4	Reactome: R-HSA-350054;Reactome: R-HSA-2894862;Reactome: R-HSA-2644606;Reactome: R-HSA-2122947	"Notch-HLH transcription pathway";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH1 Intracellular Domain Regulates Transcription"
Medex_00010801-RA	1	Reactome: R-HSA-5221030	"TET1,2,3 and TDG demethylate DNA"
Medex_00032976-RA	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
Medex_00046618-RA	1	Reactome: R-HSA-203927	"MicroRNA (miRNA) biogenesis"
Medex_00016540-RA	1	Reactome: R-HSA-9609523	"Insertion of tail-anchored proteins into the endoplasmic reticulum membrane"
Medex_00027031-RA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
Medex_00060038-RA	2	Reactome: R-HSA-70263;Reactome: R-HSA-70171	"Gluconeogenesis";"Glycolysis"
Medex_00030239-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Medex_00044988-RA	2	Reactome: R-HSA-390471;Reactome: R-HSA-1660662	"Association of TriC/CCT with target proteins during biosynthesis";"Glycosphingolipid metabolism"
Medex_00033471-RA	2	Reactome: R-HSA-2029482;Reactome: R-HSA-5663213	"Regulation of actin dynamics for phagocytic cup formation";"RHO GTPases Activate WASPs and WAVEs"
Medex_00051184-RA	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
Medex_00046375-RA	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
Medex_00018959-RA	1	Reactome: R-HSA-1799339	"SRP-dependent cotranslational protein targeting to membrane"
Medex_00039617-RA	3	Reactome: R-HSA-1474228;Reactome: R-HSA-1566948;Reactome: R-HSA-2129379	"Degradation of the extracellular matrix";"Elastic fibre formation";"Molecules associated with elastic fibres"
Medex_00077456-RA	28	Reactome: R-HSA-5696397;Reactome: R-HSA-110312;Reactome: R-HSA-5685942;Reactome: R-HSA-174437;Reactome: R-HSA-5696395;Reactome: R-HSA-912446;Reactome: R-HSA-5656121;Reactome: R-HSA-5693616;Reactome: R-HSA-5651801;Reactome: R-HSA-5655862;Reactome: R-HSA-5696400;Reactome: R-HSA-5693607;Reactome: R-HSA-5685938;Reactome: R-HSA-69166;Reactome: R-HSA-3371511;Reactome: R-HSA-6782210;Reactome: R-HSA-69473;Reactome: R-HSA-5358565;Reactome: R-HSA-6804756;Reactome: R-HSA-5656169;Reactome: R-HSA-110320;Reactome: R-HSA-6783310;Reactome: R-HSA-176187;Reactome: R-HSA-5358606;Reactome: R-HSA-6782135;Reactome: R-HSA-110314;Reactome: R-HSA-68962;Reactome: R-HSA-3371453	"Gap-filling DNA repair synthesis and ligation in GG-NER";"Translesion synthesis by REV1";"HDR through Homologous Recombination (HRR)";"Removal of the Flap Intermediate from the C-strand";"Formation of Incision Complex in GG-NER";"Meiotic recombination";"Translesion synthesis by POLI";"Presynaptic phase of homologous DNA pairing and strand exchange";"PCNA-Dependent Long Patch Base Excision Repair";"Translesion synthesis by POLK";"Dual Incision in GG-NER";"Processing of DNA double-strand break ends";"HDR through Single Strand Annealing (SSA)";"Removal of the Flap Intermediate";"HSF1 activation";"Gap-filling DNA repair synthesis and ligation in TC-NER";"G2/M DNA damage checkpoint";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"Regulation of TP53 Activity through Phosphorylation";"Termination of translesion DNA synthesis";"Translesion Synthesis by POLH";"Fanconi Anemia Pathway";"Activation of ATR in response to replication stress";"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"Dual incision in TC-NER";"Recognition of DNA damage by PCNA-containing replication complex";"Activation of the pre-replicative complex";"Regulation of HSF1-mediated heat shock response"
Medex_00036172-RA	6	KEGG: 00720+4.2.1.3;Reactome: R-HSA-1268020;KEGG: 00020+4.2.1.3;KEGG: 00290+4.2.1.33;KEGG: 00630+4.2.1.3;Reactome: R-HSA-71403	"Carbon fixation pathways in prokaryotes";"Mitochondrial protein import";"Citrate cycle (TCA cycle)";"Valine, leucine and isoleucine biosynthesis";"Glyoxylate and dicarboxylate metabolism";"Citric acid cycle (TCA cycle)"
Medex_00055600-RA	7	KEGG: 00970+2.1.2.9;MetaCyc: PWY-6613;KEGG: 00670+2.1.2.9;KEGG: 00670+2.1.2.2;KEGG: 00230+2.1.2.2;MetaCyc: PWY-6121;Reactome: R-HSA-73817	"Aminoacyl-tRNA biosynthesis";"Tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate";"One carbon pool by folate";"One carbon pool by folate";"Purine metabolism";"5-aminoimidazole ribonucleotide biosynthesis I";"Purine ribonucleoside monophosphate biosynthesis"
Medex_00082242-RA	1	Reactome: R-HSA-390648	"Muscarinic acetylcholine receptors"
Medex_00019955-RA	1	Reactome: R-HSA-425561	"Sodium/Calcium exchangers"
Medex_00021396-RA	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
Medex_00074581-RA	1	Reactome: R-HSA-5389840	"Mitochondrial translation elongation"
Medex_00004489-RA	5	MetaCyc: PWY-4983;Reactome: R-HSA-392154;KEGG: 00220+1.14.13.39;KEGG: 00330+1.14.13.39;Reactome: R-HSA-1222556	"Nitric oxide biosynthesis II (mammals)";"Nitric oxide stimulates guanylate cyclase";"Arginine biosynthesis";"Arginine and proline metabolism";"ROS and RNS production in phagocytes"
Medex_00034057-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Medex_00061555-RA	1	Reactome: R-HSA-418594	"G alpha (i) signalling events"
Medex_00049195-RA	15	Reactome: R-HSA-167290;Reactome: R-HSA-167152;Reactome: R-HSA-6807505;Reactome: R-HSA-674695;Reactome: R-HSA-167287;Reactome: R-HSA-167243;Reactome: R-HSA-176034;Reactome: R-HSA-75955;Reactome: R-HSA-9018519;Reactome: R-HSA-167238;Reactome: R-HSA-6796648;Reactome: R-HSA-112382;Reactome: R-HSA-167246;Reactome: R-HSA-167200;Reactome: R-HSA-2173796	"Pausing and recovery of HIV elongation";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA polymerase II transcribes snRNA genes";"RNA Polymerase II Pre-transcription Events";"HIV elongation arrest and recovery";"Tat-mediated HIV elongation arrest and recovery";"Interactions of Tat with host cellular proteins";"RNA Polymerase II Transcription Elongation";"Estrogen-dependent gene expression";"Pausing and recovery of Tat-mediated HIV elongation";"TP53 Regulates Transcription of DNA Repair Genes";"Formation of RNA Pol II elongation complex";"Tat-mediated elongation of the HIV-1 transcript";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription"
Medex_00043829-RA	5	Reactome: R-HSA-8948751;Reactome: R-HSA-201681;Reactome: R-HSA-5689880;MetaCyc: PWY-7511;Reactome: R-HSA-4641257	"Regulation of PTEN stability and activity";"TCF dependent signaling in response to WNT";"Ub-specific processing proteases";"Protein ubiquitination";"Degradation of AXIN"
Medex_00034172-RA	1	Reactome: R-HSA-426117	"Cation-coupled Chloride cotransporters"
Medex_00019886-RA	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
Medex_00088719-RA	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
Medex_00032018-RA	2	Reactome: R-HSA-8949215;Reactome: R-HSA-5689880	"Mitochondrial calcium ion transport";"Ub-specific processing proteases"
Medex_00052558-RA	2	Reactome: R-HSA-611105;Reactome: R-HSA-71403	"Respiratory electron transport";"Citric acid cycle (TCA cycle)"
Medex_00030264-RA	1	Reactome: R-HSA-5693571	"Nonhomologous End-Joining (NHEJ)"
Medex_00009002-RA	1	KEGG: 00270+2.1.1.37	"Cysteine and methionine metabolism"
Medex_00024605-RA	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
Medex_00014929-RA	5	Reactome: R-HSA-77387;Reactome: R-HSA-983712;Reactome: R-HSA-1222556;Reactome: R-HSA-9639288;Reactome: R-HSA-917977	"Insulin receptor recycling";"Ion channel transport";"ROS and RNS production in phagocytes";"Amino acids regulate mTORC1";"Transferrin endocytosis and recycling"
Medex_00038073-RA	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5419276;Reactome: R-HSA-5368286	"Mitochondrial translation elongation";"Mitochondrial translation termination";"Mitochondrial translation initiation"
Medex_00033089-RA	2	Reactome: R-HSA-917729;Reactome: R-HSA-162588	"Endosomal Sorting Complex Required For Transport (ESCRT)";"Budding and maturation of HIV virion"
Medex_00067288-RA	31	MetaCyc: PWY-5994;MetaCyc: PWY-8012;MetaCyc: PWY-5366;MetaCyc: PWY-5142;MetaCyc: PWY-5973;Reactome: R-HSA-163765;MetaCyc: PWY-7858;MetaCyc: PWY-7664;MetaCyc: PWYG-321;MetaCyc: PWY-5966-1;MetaCyc: PWY-6282;MetaCyc: PWY-7663;MetaCyc: PWY-7723;Reactome: R-HSA-199220;MetaCyc: PWY-8047;MetaCyc: PWY-5989;MetaCyc: PWY-5367;MetaCyc: PWY-5147;KEGG: 00780+1.1.1.100+4.2.1.59+2.3.1.41;MetaCyc: PWY-8049;MetaCyc: PWY-6799;MetaCyc: PWY-7746;Reactome: R-HSA-75105;Reactome: R-HSA-9029558;MetaCyc: PWY-5971;MetaCyc: PWY-4381;KEGG: 00061+1.1.1.100+2.3.1.85+4.2.1.59+2.3.1.39+2.3.1.41+3.1.2.14;MetaCyc: PWY-6519;MetaCyc: PWY-6113;MetaCyc: PWY-7388;Reactome: R-HSA-2426168	"Palmitate biosynthesis (animals and fungi, cytoplasm)";"Mupirocin biosynthesis";"Palmitoleate biosynthesis II (plants and bacteria)";"Acyl-[acyl-carrier protein] thioesterase pathway";"Cis-vaccenate biosynthesis";"ChREBP activates metabolic gene expression";"(5Z)-dodecenoate biosynthesis II";"Oleate biosynthesis IV (anaerobic)";"";"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)";"Palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate)";"Gondoate biosynthesis (anaerobic)";"Bacterial bioluminescence";"Vitamin B5 (pantothenate) metabolism";"Bryostatin biosynthesis";"Stearate biosynthesis II (bacteria and plants)";"Petroselinate biosynthesis";"Oleate biosynthesis I (plants)";"Biotin metabolism";"Pederin biosynthesis";"Fatty acid biosynthesis initiation (plant mitochondria)";"Mycobacterial sulfolipid biosynthesis";"Fatty acyl-CoA biosynthesis";"NR1H2 & NR1H3 regulate gene expression linked to lipogenesis";"Palmitate biosynthesis II (bacteria and plant cytoplasm)";"Fatty acid biosynthesis initiation (bacteria and plants)";"Fatty acid biosynthesis";"8-amino-7-oxononanoate biosynthesis I";"Superpathway of mycolate biosynthesis";"Octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast)";"Activation of gene expression by SREBF (SREBP)"
Medex_00004566-RA	2	Reactome: R-HSA-430039;Reactome: R-HSA-72163	"mRNA decay by 5' to 3' exoribonuclease";"mRNA Splicing - Major Pathway"
Medex_00057676-RA	2	Reactome: R-HSA-8949664;Reactome: R-HSA-1268020	"Processing of SMDT1";"Mitochondrial protein import"
Medex_00029545-RA	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
Medex_00028238-RA	10	Reactome: R-HSA-5696394;Reactome: R-HSA-380284;Reactome: R-HSA-5696395;Reactome: R-HSA-380259;Reactome: R-HSA-380270;Reactome: R-HSA-5620912;Reactome: R-HSA-2565942;Reactome: R-HSA-8854518;Reactome: R-HSA-380320;Reactome: R-HSA-3108214	"DNA Damage Recognition in GG-NER";"Loss of proteins required for interphase microtubule organization from the centrosome";"Formation of Incision Complex in GG-NER";"Loss of Nlp from mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes";"Anchoring of the basal body to the plasma membrane";"Regulation of PLK1 Activity at G2/M Transition";"AURKA Activation by TPX2";"Recruitment of NuMA to mitotic centrosomes";"SUMOylation of DNA damage response and repair proteins"
Medex_00010785-RA	2	Reactome: R-HSA-9634600;KEGG: 00051+2.7.1.105+3.1.3.46	"Regulation of glycolysis by fructose 2,6-bisphosphate metabolism";"Fructose and mannose metabolism"
Medex_00005311-RA	1	Reactome: R-HSA-8951664	"Neddylation"
Medex_00048626-RA	7	Reactome: R-HSA-389960;Reactome: R-HSA-390450;Reactome: R-HSA-5620922;Reactome: R-HSA-389957;Reactome: R-HSA-6814122;Reactome: R-HSA-6798695;Reactome: R-HSA-390471	"Formation of tubulin folding intermediates by CCT/TriC";"Folding of actin by CCT/TriC";"BBSome-mediated cargo-targeting to cilium";"Prefoldin mediated transfer of substrate to CCT/TriC";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"Neutrophil degranulation";"Association of TriC/CCT with target proteins during biosynthesis"
Medex_00070660-RA	1	Reactome: R-HSA-6798163	"Choline catabolism"
Medex_00024146-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Medex_00031730-RA	1	KEGG: 00051+4.2.1.68	"Fructose and mannose metabolism"
Medex_00081354-RA	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
Medex_00050956-RA	5	Reactome: R-HSA-6782135;Reactome: R-HSA-5696395;Reactome: R-HSA-5696400;Reactome: R-HSA-5685938;Reactome: R-HSA-6783310	"Dual incision in TC-NER";"Formation of Incision Complex in GG-NER";"Dual Incision in GG-NER";"HDR through Single Strand Annealing (SSA)";"Fanconi Anemia Pathway"
Medex_00054478-RA	1	KEGG: 00970+6.1.1.16	"Aminoacyl-tRNA biosynthesis"
Medex_00022500-RA	5	Reactome: R-HSA-68867;Reactome: R-HSA-68949;Reactome: R-HSA-176187;Reactome: R-HSA-68962;Reactome: R-HSA-176974	"Assembly of the pre-replicative complex";"Orc1 removal from chromatin";"Activation of ATR in response to replication stress";"Activation of the pre-replicative complex";"Unwinding of DNA"
Medex_00023731-RA	1	Reactome: R-HSA-2022377	"Metabolism of Angiotensinogen to Angiotensins"
Medex_00075281-RA	7	MetaCyc: PWY-8052;KEGG: 04070+3.1.4.11;MetaCyc: PWY-6367;KEGG: 00562+3.1.4.11;Reactome: R-HSA-1855204;MetaCyc: PWY-6351;MetaCyc: PWY-7039	"2-arachidonoylglycerol biosynthesis";"Phosphatidylinositol signaling system";"D-myo-inositol-5-phosphate metabolism";"Inositol phosphate metabolism";"Synthesis of IP3 and IP4 in the cytosol";"D-myo-inositol (1,4,5)-trisphosphate biosynthesis";"Phosphatidate metabolism, as a signaling molecule"
Medex_00022119-RA	8	Reactome: R-HSA-6791462;Reactome: R-HSA-71336;Reactome: R-HSA-6791055;Reactome: R-HSA-8950505;MetaCyc: PWY-5723;KEGG: 00030+2.2.1.2;Reactome: R-HSA-163754;MetaCyc: PWY-1861	"TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P";"Pentose phosphate pathway";"TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P";"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation";"Rubisco shunt";"Pentose phosphate pathway";"Insulin effects increased synthesis of Xylulose-5-Phosphate";"Formaldehyde assimilation II (assimilatory RuMP Cycle)"
Medex_00037995-RA	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
Medex_00011601-RA	4	KEGG: 00513+2.4.1.261;Reactome: R-HSA-4720454;Reactome: R-HSA-446193;KEGG: 00510+2.4.1.259+2.4.1.261	"Various types of N-glycan biosynthesis";"Defective ALG9 causes ALG9-CDG (CDG-1l)";"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"N-Glycan biosynthesis"
Medex_00034881-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Medex_00096221-RA	2	Reactome: R-HSA-5693568;Reactome: R-HSA-6783310	"Resolution of D-loop Structures through Holliday Junction Intermediates";"Fanconi Anemia Pathway"
Medex_00092710-RA	1	Reactome: R-HSA-912446	"Meiotic recombination"
Medex_00036291-RA	2	KEGG: 00051+5.3.1.5;KEGG: 00040+5.3.1.5	"Fructose and mannose metabolism";"Pentose and glucuronate interconversions"
Medex_00073798-RA	7	KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1	"Thermogenesis";"Relaxin signaling pathway";"Human cytomegalovirus infection";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"PI3K-Akt signaling pathway";"mTOR signaling pathway"
Medex_00069966-RA	6	Reactome: R-HSA-6796648;Reactome: R-HSA-5358606;Reactome: R-HSA-5632927;Reactome: R-HSA-5632968;Reactome: R-HSA-5358565;Reactome: R-HSA-5632928	"TP53 Regulates Transcription of DNA Repair Genes";"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"Defective Mismatch Repair Associated With MSH3";"Defective Mismatch Repair Associated With MSH6";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"Defective Mismatch Repair Associated With MSH2"
Medex_00019891-RA	2	Reactome: R-HSA-6814122;Reactome: R-HSA-418594	"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"G alpha (i) signalling events"
Medex_00091445-RA	5	KEGG: 00760+2.7.1.23;MetaCyc: PWY-7269;Reactome: R-HSA-196807;MetaCyc: PWY-5083;MetaCyc: PWY-7268	"Nicotinate and nicotinamide metabolism";"NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)";"Nicotinate metabolism";"NAD/NADH phosphorylation and dephosphorylation";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)"
Medex_00028254-RA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
Medex_00088769-RA	3	Reactome: R-HSA-194840;Reactome: R-HSA-416482;Reactome: R-HSA-193648	"Rho GTPase cycle";"G alpha (12/13) signalling events";"NRAGE signals death through JNK"
Medex_00030515-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00047124-RA	1	Reactome: R-HSA-425561	"Sodium/Calcium exchangers"
Medex_00014172-RA	13	MetaCyc: PWY-7384;MetaCyc: PWY-5690;KEGG: 00660+6.2.1.5;MetaCyc: PWY-5913;MetaCyc: PWY-6969;MetaCyc: PWY-6728;MetaCyc: PWY-5537;MetaCyc: PWY-5538;KEGG: 00020+6.2.1.5;Reactome: R-HSA-71403;KEGG: 00640+6.2.1.5;MetaCyc: PWY-5392;KEGG: 00720+6.2.1.5	"Anaerobic energy metabolism (invertebrates, mitochondrial)";"TCA cycle II (plants and fungi)";"C5-Branched dibasic acid metabolism";"Partial TCA cycle (obligate autotrophs)";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Methylaspartate cycle";"Pyruvate fermentation to acetate V";"Pyruvate fermentation to acetate VI";"Citrate cycle (TCA cycle)";"Citric acid cycle (TCA cycle)";"Propanoate metabolism";"Reductive TCA cycle II";"Carbon fixation pathways in prokaryotes"
Medex_00010786-RA	2	Reactome: R-HSA-9634600;KEGG: 00051+2.7.1.105+3.1.3.46	"Regulation of glycolysis by fructose 2,6-bisphosphate metabolism";"Fructose and mannose metabolism"
Medex_00054467-RA	1	Reactome: R-HSA-977347	"Serine biosynthesis"
Medex_00059422-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00062597-RA	3	Reactome: R-HSA-5663213;Reactome: R-HSA-2029482;Reactome: R-HSA-4420097	"RHO GTPases Activate WASPs and WAVEs";"Regulation of actin dynamics for phagocytic cup formation";"VEGFA-VEGFR2 Pathway"
Medex_00001778-RA	2	Reactome: R-HSA-389661;Reactome: R-HSA-9033241	"Glyoxylate metabolism and glycine degradation";"Peroxisomal protein import"
Medex_00051270-RA	1	Reactome: R-HSA-437239	"Recycling pathway of L1"
Medex_00076187-RA	5	MetaCyc: PWY-6892;MetaCyc: PWY-6891;MetaCyc: PWY-7560;KEGG: 00900+2.2.1.7;KEGG: 00730+2.2.1.7	"Thiazole biosynthesis I (facultative anaerobic bacteria)";"Thiazole biosynthesis II (aerobic bacteria)";"Methylerythritol phosphate pathway II";"Terpenoid backbone biosynthesis";"Thiamine metabolism"
Medex_00070641-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Medex_00059033-RA	6	MetaCyc: PWY-922;KEGG: 00900+2.7.1.36;Reactome: R-HSA-2426168;MetaCyc: PWY-6174;MetaCyc: PWY-7391;Reactome: R-HSA-191273	"Mevalonate pathway I";"Terpenoid backbone biosynthesis";"Activation of gene expression by SREBF (SREBP)";"Mevalonate pathway II (archaea)";"Isoprene biosynthesis II (engineered)";"Cholesterol biosynthesis"
Medex_00040229-RA	1	Reactome: R-HSA-2024096	"HS-GAG degradation"
Medex_00018892-RA	3	Reactome: R-HSA-212436;Reactome: R-HSA-1989781;Reactome: R-HSA-381340	"Generic Transcription Pathway";"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation"
Medex_00057648-RA	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
Medex_00091106-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Medex_00063756-RA	26	Reactome: R-HSA-8941856;Reactome: R-HSA-3134973;Reactome: R-HSA-9617629;Reactome: R-HSA-2644606;Reactome: R-HSA-9013508;Reactome: R-HSA-3214847;Reactome: R-HSA-201722;Reactome: R-HSA-1989781;Reactome: R-HSA-400253;Reactome: R-HSA-1912408;Reactome: R-HSA-210744;Reactome: R-HSA-9614657;Reactome: R-HSA-8866907;Reactome: R-HSA-1234158;Reactome: R-HSA-2122947;Reactome: R-HSA-9013695;Reactome: R-HSA-381340;Reactome: R-HSA-2894862;Reactome: R-HSA-3899300;Reactome: R-HSA-5621575;Reactome: R-HSA-933541;Reactome: R-HSA-918233;Reactome: R-HSA-3371568;Reactome: R-HSA-5617472;Reactome: R-HSA-1368082;Reactome: R-HSA-9018519	"RUNX3 regulates NOTCH signaling";"LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production";"Regulation of FOXO transcriptional activity by acetylation";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH3 Intracellular Domain Regulates Transcription";"HATs acetylate histones";"Formation of the beta-catenin:TCF transactivating complex";"PPARA activates gene expression";"Circadian Clock";"Pre-NOTCH Transcription and Translation";"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"FOXO-mediated transcription of cell death genes";"Activation of the TFAP2 (AP-2) family of transcription factors";"Regulation of gene expression by Hypoxia-inducible Factor";"NOTCH1 Intracellular Domain Regulates Transcription";"NOTCH4 Intracellular Domain Regulates Transcription";"Transcriptional regulation of white adipocyte differentiation";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"SUMOylation of transcription cofactors";"CD209 (DC-SIGN) signaling";"TRAF6 mediated IRF7 activation";"TRAF3-dependent IRF activation pathway";"Attenuation phase";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"RORA activates gene expression";"Estrogen-dependent gene expression"
Medex_00038538-RA	1	Reactome: R-HSA-6790901	"rRNA modification in the nucleus and cytosol"
Medex_00083141-RA	1	Reactome: R-HSA-156584	"Cytosolic sulfonation of small molecules"
Medex_00039792-RA	2	Reactome: R-HSA-975957;Reactome: R-HSA-9010553	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs"
Medex_00023685-RA	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
Medex_00055244-RA	1	Reactome: R-HSA-9633012	"Response of EIF2AK4 (GCN2) to amino acid deficiency"
Medex_00011530-RA	5	KEGG: 00565+2.5.1.26;MetaCyc: PWY-7782;Reactome: R-HSA-75896;Reactome: R-HSA-9033241;Reactome: R-HSA-9033500	"Ether lipid metabolism";"Plasmalogen biosynthesis";"Plasmalogen biosynthesis";"Peroxisomal protein import";"TYSND1 cleaves peroxisomal proteins"
Medex_00003847-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Medex_00041575-RA	24	Reactome: R-HSA-418555;Reactome: R-HSA-4086398;Reactome: R-HSA-163359;Reactome: R-HSA-418217;Reactome: R-HSA-8964315;Reactome: R-HSA-416482;Reactome: R-HSA-381676;Reactome: R-HSA-456926;Reactome: R-HSA-418597;Reactome: R-HSA-418594;Reactome: R-HSA-416476;Reactome: R-HSA-500657;Reactome: R-HSA-392170;Reactome: R-HSA-8964616;Reactome: R-HSA-9009391;Reactome: R-HSA-6814122;Reactome: R-HSA-428930;Reactome: R-HSA-418592;Reactome: R-HSA-420092;Reactome: R-HSA-432040;Reactome: R-HSA-202040;Reactome: R-HSA-392451;Reactome: R-HSA-400042;Reactome: R-HSA-392851	"G alpha (s) signalling events";"Ca2+ pathway";"Glucagon signaling in metabolic regulation";"G beta:gamma signalling through PLC beta";"G beta:gamma signalling through BTK";"G alpha (12/13) signalling events";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"Thrombin signalling through proteinase activated receptors (PARs)";"G alpha (z) signalling events";"G alpha (i) signalling events";"G alpha (q) signalling events";"Presynaptic function of Kainate receptors";"ADP signalling through P2Y purinoceptor 12";"G beta:gamma signalling through CDC42";"Extra-nuclear estrogen signaling";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"Thromboxane signalling through TP receptor";"ADP signalling through P2Y purinoceptor 1";"Glucagon-type ligand receptors";"Vasopressin regulates renal water homeostasis via Aquaporins";"G-protein activation";"G beta:gamma signalling through PI3Kgamma";"Adrenaline,noradrenaline inhibits insulin secretion";"Prostacyclin signalling through prostacyclin receptor"
Medex_00066775-RA	3	KEGG: 00510+2.4.1.267;Reactome: R-HSA-4724289;Reactome: R-HSA-446193	"N-Glycan biosynthesis";"Defective ALG6 causes ALG6-CDG (CDG-1c)";"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein"
Medex_00023732-RA	1	Reactome: R-HSA-2022377	"Metabolism of Angiotensinogen to Angiotensins"
Medex_00064009-RA	6	Reactome: R-HSA-72706;Reactome: R-HSA-72689;Reactome: R-HSA-72702;Reactome: R-HSA-72649;Reactome: R-HSA-156827;Reactome: R-HSA-72695	"GTP hydrolysis and joining of the 60S ribosomal subunit";"Formation of a pool of free 40S subunits";"Ribosomal scanning and start codon recognition";"Translation initiation complex formation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Formation of the ternary complex, and subsequently, the 43S complex"
Medex_00081115-RA	2	Reactome: R-HSA-72163;Reactome: R-HSA-6807505	"mRNA Splicing - Major Pathway";"RNA polymerase II transcribes snRNA genes"
Medex_00041400-RA	5	Reactome: R-HSA-879415;Reactome: R-HSA-532668;Reactome: R-HSA-8957275;Reactome: R-HSA-381426;Reactome: R-HSA-901042	"Advanced glycosylation endproduct receptor signaling";"N-glycan trimming in the ER and Calnexin/Calreticulin cycle";"Post-translational protein phosphorylation";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"Calnexin/calreticulin cycle"
Medex_00017181-RA	3	KEGG: 00480+1.1.1.44;Reactome: R-HSA-71336;KEGG: 00030+1.1.1.44	"Glutathione metabolism";"Pentose phosphate pathway";"Pentose phosphate pathway"
Medex_00063828-RA	6	Reactome: R-HSA-176187;Reactome: R-HSA-68962;Reactome: R-HSA-176974;Reactome: R-HSA-68867;Reactome: R-HSA-68949;Reactome: R-HSA-69052	"Activation of ATR in response to replication stress";"Activation of the pre-replicative complex";"Unwinding of DNA";"Assembly of the pre-replicative complex";"Orc1 removal from chromatin";"Switching of origins to a post-replicative state"
Medex_00085628-RA	3	Reactome: R-HSA-5173105;Reactome: R-HSA-2022854;Reactome: R-HSA-5083627	"O-linked glycosylation";"Keratan sulfate biosynthesis";"Defective LARGE causes MDDGA6 and MDDGB6"
Medex_00038461-RA	2	Reactome: R-HSA-6807878;Reactome: R-HSA-6811434	"COPI-mediated anterograde transport";"COPI-dependent Golgi-to-ER retrograde traffic"
Medex_00043116-RA	1	KEGG: 00760+2.3.1.286	"Nicotinate and nicotinamide metabolism"
Medex_00096648-RA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
Medex_00002600-RA	4	Reactome: R-HSA-2894862;Reactome: R-HSA-350054;Reactome: R-HSA-2122947;Reactome: R-HSA-2644606	"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Notch-HLH transcription pathway";"NOTCH1 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 PEST Domain Mutants"
Medex_00062703-RA	1	Reactome: R-HSA-2028269	"Signaling by Hippo"
Medex_00045105-RA	2	Reactome: R-HSA-418457;Reactome: R-HSA-1296052	"cGMP effects";"Ca2+ activated K+ channels"
Medex_00071834-RA	3	KEGG: 00730+3.1.3.2;KEGG: 00740+3.1.3.2;MetaCyc: PWY-6348	"Thiamine metabolism";"Riboflavin metabolism";"Phosphate acquisition"
Medex_00007587-RA	2	KEGG: 00900+2.5.1.58;Reactome: R-HSA-2514859	"Terpenoid backbone biosynthesis";"Inactivation, recovery and regulation of the phototransduction cascade"
Medex_00046215-RA	3	KEGG: 00350+3.7.1.2;Reactome: R-HSA-8963684;KEGG: 00643+3.7.1.2	"Tyrosine metabolism";"Tyrosine catabolism";"Styrene degradation"
Medex_00056600-RA	7	KEGG: 00230+1.1.1.205;Reactome: R-HSA-6798695;MetaCyc: PWY-7221;Reactome: R-HSA-73817;MetaCyc: PWY-6596;MetaCyc: PWY-5695;KEGG: 00983+1.1.1.205	"Purine metabolism";"Neutrophil degranulation";"Guanosine ribonucleotides de novo biosynthesis";"Purine ribonucleoside monophosphate biosynthesis";"Adenosine nucleotides degradation I";"Inosine 5'-phosphate degradation";"Drug metabolism - other enzymes"
Medex_00016355-RA	2	Reactome: R-HSA-8876198;Reactome: R-HSA-204005	"RAB GEFs exchange GTP for GDP on RABs";"COPII-mediated vesicle transport"
Medex_00004865-RA	5	Reactome: R-HSA-159231;Reactome: R-HSA-77595;Reactome: R-HSA-72163;Reactome: R-HSA-72187;Reactome: R-HSA-73856	"Transport of Mature mRNA Derived from an Intronless Transcript";"Processing of Intronless Pre-mRNAs";"mRNA Splicing - Major Pathway";"mRNA 3'-end processing";"RNA Polymerase II Transcription Termination"
Medex_00067008-RA	12	MetaCyc: PWY-801;MetaCyc: PWY-6842;MetaCyc: PWY-6309;MetaCyc: PWY-601;Reactome: R-HSA-71240;KEGG: 00270+4.4.1.13;KEGG: 00450+4.4.1.13;KEGG: 00380+2.6.1.7;MetaCyc: PWY-7901;MetaCyc: PWY-6936;MetaCyc: PWY-2821;MetaCyc: PWY-1187	"Homocysteine and cysteine interconversion";"Glutathione-mediated detoxification II";"L-tryptophan degradation XI (mammalian, via kynurenine)";"Glucosinolate biosynthesis from tryptophan";"Tryptophan catabolism";"Cysteine and methionine metabolism";"Selenocompound metabolism";"Tryptophan metabolism";"Glucosinolate biosynthesis from tyrosine";"Seleno-amino acid biosynthesis (plants)";"Glucosinolate biosynthesis from phenylalanine";"Glucosinolate biosynthesis from homomethionine"
Medex_00077083-RA	8	Reactome: R-HSA-69091;Reactome: R-HSA-68952;Reactome: R-HSA-68962;Reactome: R-HSA-113501;Reactome: R-HSA-174411;Reactome: R-HSA-69183;Reactome: R-HSA-69166;Reactome: R-HSA-174430	"Polymerase switching";"DNA replication initiation";"Activation of the pre-replicative complex";"Inhibition of replication initiation of damaged DNA by RB1/E2F1";"Polymerase switching on the C-strand of the telomere";"Processive synthesis on the lagging strand";"Removal of the Flap Intermediate";"Telomere C-strand synthesis initiation"
Medex_00005998-RA	2	Reactome: R-HSA-3214847;Reactome: R-HSA-5689880	"HATs acetylate histones";"Ub-specific processing proteases"
Medex_00055875-RA	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00102196-RA	3	MetaCyc: PWY-7831;Reactome: R-HSA-9033807;MetaCyc: PWY-7833	"ABH and Lewis epitopes biosynthesis from type 2 precursor disaccharide";"ABO blood group biosynthesis";"Biosynthesis of Lewis epitopes (H. pylori)"
Medex_00002230-RA	2	Reactome: R-HSA-73614;Reactome: R-HSA-73621	"Pyrimidine salvage";"Pyrimidine catabolism"
Medex_00088331-RA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00077516-RA	2	Reactome: R-HSA-8949613;Reactome: R-HSA-163210	"Cristae formation";"Formation of ATP by chemiosmotic coupling"
Medex_00069281-RA	6	Reactome: R-HSA-8951430;Reactome: R-HSA-4411364;Reactome: R-HSA-201722;Reactome: R-HSA-3769402;Reactome: R-HSA-4641265;Reactome: R-HSA-4086398	"RUNX3 regulates WNT signaling";"Binding of TCF/LEF:CTNNB1 to target gene promoters";"Formation of the beta-catenin:TCF transactivating complex";"Deactivation of the beta-catenin transactivating complex";"Repression of WNT target genes";"Ca2+ pathway"
Medex_00054482-RA	1	Reactome: R-HSA-69231	"Cyclin D associated events in G1"
Medex_00030747-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Medex_00002001-RA	6	Reactome: R-HSA-110362;Reactome: R-HSA-162594;Reactome: R-HSA-5651801;Reactome: R-HSA-174437;Reactome: R-HSA-69166;Reactome: R-HSA-5685939	"POLB-Dependent Long Patch Base Excision Repair";"Early Phase of HIV Life Cycle";"PCNA-Dependent Long Patch Base Excision Repair";"Removal of the Flap Intermediate from the C-strand";"Removal of the Flap Intermediate";"HDR through MMEJ (alt-NHEJ)"
Medex_00012330-RA	1	Reactome: R-HSA-8849175	"Threonine catabolism"
Medex_00055084-RA	13	Reactome: R-HSA-8948216;Reactome: R-HSA-2022090;Reactome: R-HSA-1650814;Reactome: R-HSA-1442490;Reactome: R-HSA-2243919;Reactome: R-HSA-216083;Reactome: R-HSA-3000178;Reactome: R-HSA-3000171;Reactome: R-HSA-186797;Reactome: R-HSA-2214320;Reactome: R-HSA-3000157;Reactome: R-HSA-1474244;Reactome: R-HSA-419037	"Collagen chain trimerization";"Assembly of collagen fibrils and other multimeric structures";"Collagen biosynthesis and modifying enzymes";"Collagen degradation";"Crosslinking of collagen fibrils";"Integrin cell surface interactions";"ECM proteoglycans";"Non-integrin membrane-ECM interactions";"Signaling by PDGF";"Anchoring fibril formation";"Laminin interactions";"Extracellular matrix organization";"NCAM1 interactions"
Medex_00061309-RA	7	MetaCyc: PWY-6737;MetaCyc: PWY-5941;KEGG: 00500+2.4.1.25;MetaCyc: PWY-6724;MetaCyc: PWY-7238;Reactome: R-HSA-70221;Reactome: R-HSA-6798695	"Starch degradation V";"Glycogen degradation II";"Starch and sucrose metabolism";"Starch degradation II";"Sucrose biosynthesis II";"Glycogen breakdown (glycogenolysis)";"Neutrophil degranulation"
Medex_00003011-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Medex_00099636-RA	9	Reactome: R-HSA-69656;Reactome: R-HSA-2173796;Reactome: R-HSA-69205;Reactome: R-HSA-1362300;Reactome: R-HSA-69231;Reactome: R-HSA-1538133;Reactome: R-HSA-6804114;Reactome: R-HSA-1362277;Reactome: R-HSA-69202	"Cyclin A:Cdk2-associated events at S phase entry";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"G1/S-Specific Transcription";"Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1";"Cyclin D associated events in G1";"G0 and Early G1";"TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest";"Transcription of E2F targets under negative control by DREAM complex";"Cyclin E associated events during G1/S transition"
Medex_00044000-RA	4	KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16;Reactome: R-HSA-6807505;KEGG: 05235+3.1.3.16	"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation";"RNA polymerase II transcribes snRNA genes";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
Medex_00010414-RA	2	KEGG: 00760+6.3.1.5;Reactome: R-HSA-196807	"Nicotinate and nicotinamide metabolism";"Nicotinate metabolism"
Medex_00021710-RA	10	MetaCyc: PWY-4061;MetaCyc: PWY-8001;MetaCyc: PWY-7559;MetaCyc: PWY-7112;KEGG: 00480+2.3.2.2+3.4.19.13;KEGG: 00430+2.3.2.2;MetaCyc: PWY-4041;KEGG: 00460+2.3.2.2;MetaCyc: PWY-5826;MetaCyc: PWY-6842	"Glutathione-mediated detoxification I";"Felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis";"Glutathione degradation (DUG pathway";"4-hydroxy-2-nonenal detoxification";"Glutathione metabolism";"Taurine and hypotaurine metabolism";"Gamma-glutamyl cycle";"Cyanoamino acid metabolism";"Hypoglycin biosynthesis";"Glutathione-mediated detoxification II"
Medex_00025243-RA	13	Reactome: R-HSA-6802952;KEGG: 04151+2.7.11.1;Reactome: R-HSA-6802955;Reactome: R-HSA-5674135;KEGG: 04926+2.7.11.1;Reactome: R-HSA-6802948;KEGG: 05163+2.7.11.1;KEGG: 05170+2.7.11.1;Reactome: R-HSA-9649948;Reactome: R-HSA-6802946;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1	"Signaling by BRAF and RAF fusions";"PI3K-Akt signaling pathway";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"MAP2K and MAPK activation";"Relaxin signaling pathway";"Signaling by high-kinase activity BRAF mutants";"Human cytomegalovirus infection";"Human immunodeficiency virus 1 infection";"Signaling downstream of RAS mutants";"Signaling by moderate kinase activity BRAF mutants";"Human papillomavirus infection";"mTOR signaling pathway";"Thermogenesis"
Medex_00035719-RA	2	KEGG: 00480+1.11.1.15;Reactome: R-HSA-3299685	"Glutathione metabolism";"Detoxification of Reactive Oxygen Species"
Medex_00065002-RA	3	Reactome: R-HSA-420029;MetaCyc: PWY-7221;KEGG: 00230+2.7.4.8	"Tight junction interactions";"Guanosine ribonucleotides de novo biosynthesis";"Purine metabolism"
Medex_00056450-RA	8	Reactome: R-HSA-6798695;Reactome: R-HSA-111464;Reactome: R-HSA-9627069;Reactome: R-HSA-8953750;Reactome: R-HSA-111458;Reactome: R-HSA-111463;Reactome: R-HSA-111459;Reactome: R-HSA-6803207	"Neutrophil degranulation";"SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes";"Regulation of the apoptosome activity";"Transcriptional Regulation by E2F6";"Formation of apoptosome";"SMAC (DIABLO) binds to IAPs";"Activation of caspases through apoptosome-mediated cleavage";"TP53 Regulates Transcription of Caspase Activators and Caspases"
Medex_00022947-RA	2	Reactome: R-HSA-429947;Reactome: R-HSA-6804115	"Deadenylation of mRNA";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"
Medex_00018514-RA	3	Reactome: R-HSA-6798695;MetaCyc: PWY-6807;KEGG: 00511+3.2.1.51	"Neutrophil degranulation";"Xyloglucan degradation II (exoglucanase)";"Other glycan degradation"
Medex_00057171-RA	2	Reactome: R-HSA-390471;Reactome: R-HSA-1660662	"Association of TriC/CCT with target proteins during biosynthesis";"Glycosphingolipid metabolism"
Medex_00099588-RA	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
Medex_00066527-RA	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
Medex_00065223-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00091562-RA	7	Reactome: R-HSA-5362768;Reactome: R-HSA-8951664;Reactome: R-HSA-901032;Reactome: R-HSA-5358346;Reactome: R-HSA-381038;MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Neddylation";"ER Quality Control Compartment (ERQC)";"Hedgehog ligand biogenesis";"XBP1(S) activates chaperone genes";"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00084753-RA	2	Reactome: R-HSA-163282;Reactome: R-HSA-2151201	"Mitochondrial transcription initiation";"Transcriptional activation of mitochondrial biogenesis"
Medex_00051001-RA	3	Reactome: R-HSA-1445148;Reactome: R-HSA-264876;Reactome: R-HSA-5620916	"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Insulin processing";"VxPx cargo-targeting to cilium"
Medex_00022518-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00020520-RA	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
Medex_00043586-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00007745-RA	11	KEGG: 00640+6.4.1.2;Reactome: R-HSA-163765;KEGG: 00620+6.4.1.2;MetaCyc: PWY-6679;KEGG: 00254+6.4.1.2;Reactome: R-HSA-196780;KEGG: 00720+6.4.1.2;Reactome: R-HSA-2426168;KEGG: 00061+6.4.1.2;Reactome: R-HSA-200425;MetaCyc: PWY-5966-1	"Propanoate metabolism";"ChREBP activates metabolic gene expression";"Pyruvate metabolism";"Jadomycin biosynthesis";"Aflatoxin biosynthesis";"Biotin transport and metabolism";"Carbon fixation pathways in prokaryotes";"Activation of gene expression by SREBF (SREBP)";"Fatty acid biosynthesis";"Carnitine metabolism";"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)"
Medex_00028363-RA	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
Medex_00070856-RA	7	KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1	"Thermogenesis";"Relaxin signaling pathway";"Human cytomegalovirus infection";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"PI3K-Akt signaling pathway";"mTOR signaling pathway"
Medex_00052900-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00002916-RA	5	KEGG: 00520+3.2.1.14;MetaCyc: PWY-6855;MetaCyc: PWY-7822;Reactome: R-HSA-189085;MetaCyc: PWY-6902	"Amino sugar and nucleotide sugar metabolism";"Chitin degradation I (archaea)";"Chitin degradation III (Serratia)";"Digestion of dietary carbohydrate";"Chitin degradation II (Vibrio)"
Medex_00005953-RA	1	Reactome: R-HSA-6802952	"Signaling by BRAF and RAF fusions"
Medex_00039739-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00074850-RA	4	Reactome: R-HSA-400511;Reactome: R-HSA-422085;Reactome: R-HSA-381771;Reactome: R-HSA-1799339	"Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)";"Synthesis, secretion, and deacylation of Ghrelin";"Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)";"SRP-dependent cotranslational protein targeting to membrane"
Medex_00015007-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00038761-RA	1	Reactome: R-HSA-75153	"Apoptotic execution phase"
Medex_00019576-RA	2	Reactome: R-HSA-2142753;KEGG: 00970+6.3.5.7	"Arachidonic acid metabolism";"Aminoacyl-tRNA biosynthesis"
Medex_00007446-RA	1	Reactome: R-HSA-6798163	"Choline catabolism"
Medex_00066810-RA	6	Reactome: R-HSA-6798695;KEGG: 00630+1.11.1.6;Reactome: R-HSA-9033241;KEGG: 00380+1.11.1.6;Reactome: R-HSA-9615017;Reactome: R-HSA-3299685	"Neutrophil degranulation";"Glyoxylate and dicarboxylate metabolism";"Peroxisomal protein import";"Tryptophan metabolism";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"Detoxification of Reactive Oxygen Species"
Medex_00040040-RA	1	Reactome: R-HSA-8950505	"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"
Medex_00033225-RA	3	Reactome: R-HSA-4086400;Reactome: R-HSA-4608870;Reactome: R-HSA-373080	"PCP/CE pathway";"Asymmetric localization of PCP proteins";"Class B/2 (Secretin family receptors)"
Medex_00034927-RA	4	KEGG: 00270+2.5.1.6;MetaCyc: PWY-5041;MetaCyc: PWY-5912;Reactome: R-HSA-156581	"Cysteine and methionine metabolism";"S-adenosyl-L-methionine cycle II";"2'-deoxymugineic acid phytosiderophore biosynthesis";"Methylation"
Medex_00034578-RA	6	Reactome: R-HSA-69473;Reactome: R-HSA-5693607;Reactome: R-HSA-6804756;Reactome: R-HSA-5685938;Reactome: R-HSA-176187;Reactome: R-HSA-5693616	"G2/M DNA damage checkpoint";"Processing of DNA double-strand break ends";"Regulation of TP53 Activity through Phosphorylation";"HDR through Single Strand Annealing (SSA)";"Activation of ATR in response to replication stress";"Presynaptic phase of homologous DNA pairing and strand exchange"
Medex_00081758-RA	6	MetaCyc: PWY-2221;MetaCyc: PWY-5530;KEGG: 00030+3.1.1.17;KEGG: 00930+3.1.1.17;KEGG: 00053+3.1.1.17;MetaCyc: PWY-7165	"Entner-Doudoroff pathway III (semi-phosphorylative)";"Sorbitol biosynthesis II";"Pentose phosphate pathway";"Caprolactam degradation";"Ascorbate and aldarate metabolism";"L-ascorbate biosynthesis VI (engineered pathway)"
Medex_00007620-RA	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
Medex_00003384-RA	33	Reactome: R-HSA-168333;Reactome: R-HSA-2467813;Reactome: R-HSA-1169408;Reactome: R-HSA-68877;Reactome: R-HSA-159231;Reactome: R-HSA-9648025;Reactome: R-HSA-159227;Reactome: R-HSA-159230;Reactome: R-HSA-5663220;Reactome: R-HSA-168271;Reactome: R-HSA-3232142;Reactome: R-HSA-170822;Reactome: R-HSA-4551638;Reactome: R-HSA-141444;Reactome: R-HSA-191859;Reactome: R-HSA-168325;Reactome: R-HSA-165054;Reactome: R-HSA-180746;Reactome: R-HSA-4615885;Reactome: R-HSA-3371453;Reactome: R-HSA-2500257;Reactome: R-HSA-5578749;Reactome: R-HSA-168276;Reactome: R-HSA-180910;Reactome: R-HSA-3301854;Reactome: R-HSA-4085377;Reactome: R-HSA-4570464;Reactome: R-HSA-9610379;Reactome: R-HSA-5619107;Reactome: R-HSA-9609690;Reactome: R-HSA-6784531;Reactome: R-HSA-3108214;Reactome: R-HSA-159236	"NEP/NS2 Interacts with the Cellular Export Machinery";"Separation of Sister Chromatids";"ISG15 antiviral mechanism";"Mitotic Prometaphase";"Transport of Mature mRNA Derived from an Intronless Transcript";"EML4 and NUDC in mitotic spindle formation";"Transport of the SLBP independent Mature mRNA";"Transport of the SLBP Dependant Mature mRNA";"RHO GTPases Activate Formins";"Transport of Ribonucleoproteins into the Host Nucleus";"SUMOylation of ubiquitinylation proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"SUMOylation of chromatin organization proteins";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"snRNP Assembly";"Viral Messenger RNA Synthesis";"Rev-mediated nuclear export of HIV RNA";"Nuclear import of Rev protein";"SUMOylation of DNA replication proteins";"Regulation of HSF1-mediated heat shock response";"Resolution of Sister Chromatid Cohesion";"Transcriptional regulation by small RNAs";"NS1 Mediated Effects on Host Pathways";"Vpr-mediated nuclear import of PICs";"Nuclear Pore Complex (NPC) Disassembly";"SUMOylation of SUMOylation proteins";"SUMOylation of RNA binding proteins";"HCMV Late Events";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"HCMV Early Events";"tRNA processing in the nucleus";"SUMOylation of DNA damage response and repair proteins";"Transport of Mature mRNA derived from an Intron-Containing Transcript"
Medex_00033015-RA	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
Medex_00008838-RA	1	Reactome: R-HSA-9633012	"Response of EIF2AK4 (GCN2) to amino acid deficiency"
Medex_00092416-RA	7	KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1	"Human papillomavirus infection";"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Human cytomegalovirus infection";"Thermogenesis";"Relaxin signaling pathway"
Medex_00049296-RA	7	Reactome: R-HSA-3108214;Reactome: R-HSA-2468052;Reactome: R-HSA-2500257;Reactome: R-HSA-1221632;Reactome: R-HSA-2467813;Reactome: R-HSA-2470946;Reactome: R-HSA-9018519	"SUMOylation of DNA damage response and repair proteins";"Establishment of Sister Chromatid Cohesion";"Resolution of Sister Chromatid Cohesion";"Meiotic synapsis";"Separation of Sister Chromatids";"Cohesin Loading onto Chromatin";"Estrogen-dependent gene expression"
Medex_00055538-RA	6	Reactome: R-HSA-210500;Reactome: R-HSA-388844;Reactome: R-HSA-181429;Reactome: R-HSA-264642;Reactome: R-HSA-212676;Reactome: R-HSA-181430	"Glutamate Neurotransmitter Release Cycle";"Receptor-type tyrosine-protein phosphatases";"Serotonin Neurotransmitter Release Cycle";"Acetylcholine Neurotransmitter Release Cycle";"Dopamine Neurotransmitter Release Cycle";"Norepinephrine Neurotransmitter Release Cycle"
Medex_00047673-RA	4	MetaCyc: PWY-7822;MetaCyc: PWY-6855;MetaCyc: PWY-6902;KEGG: 00520+3.2.1.14	"Chitin degradation III (Serratia)";"Chitin degradation I (archaea)";"Chitin degradation II (Vibrio)";"Amino sugar and nucleotide sugar metabolism"
Medex_00028014-RA	3	Reactome: R-HSA-5663213;Reactome: R-HSA-3928662;Reactome: R-HSA-2029482	"RHO GTPases Activate WASPs and WAVEs";"EPHB-mediated forward signaling";"Regulation of actin dynamics for phagocytic cup formation"
Medex_00083227-RA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Medex_00028627-RA	14	MetaCyc: PWY-6886;MetaCyc: PWY-2221;MetaCyc: PWY-6901;KEGG: 00010+4.2.1.11;MetaCyc: PWY-6142;MetaCyc: PWY-1622;MetaCyc: PWY-7003;MetaCyc: PWY-1042;MetaCyc: PWY-5723;MetaCyc: PWY-8004;KEGG: 00680+4.2.1.11;MetaCyc: PWY-7124;MetaCyc: PWY-7218;MetaCyc: PWY-5484	"1-butanol autotrophic biosynthesis (engineered)";"Entner-Doudoroff pathway III (semi-phosphorylative)";"Superpathway of glucose and xylose degradation";"Glycolysis / Gluconeogenesis";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Formaldehyde assimilation I (serine pathway)";"Glycerol degradation to butanol";"Glycolysis IV (plant cytosol)";"Rubisco shunt";"Entner-Doudoroff pathway I";"Methane metabolism";"Ethylene biosynthesis V (engineered)";"Photosynthetic 3-hydroxybutanoate biosynthesis (engineered)";"Glycolysis II (from fructose 6-phosphate)"
Medex_00078419-RA	1	Reactome: R-HSA-1221632	"Meiotic synapsis"
Medex_00076466-RA	18	Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-72695;Reactome: R-HSA-156902;Reactome: R-HSA-72649;Reactome: R-HSA-192823;Reactome: R-HSA-2408557;Reactome: R-HSA-6790901;Reactome: R-HSA-72689;Reactome: R-HSA-9633012;Reactome: R-HSA-1799339;Reactome: R-HSA-166208;Reactome: R-HSA-975957;Reactome: R-HSA-6791226;Reactome: R-HSA-72702;Reactome: R-HSA-72764;Reactome: R-HSA-975956;Reactome: R-HSA-72706	"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Formation of the ternary complex, and subsequently, the 43S complex";"Peptide chain elongation";"Translation initiation complex formation";"Viral mRNA Translation";"Selenocysteine synthesis";"rRNA modification in the nucleus and cytosol";"Formation of a pool of free 40S subunits";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"SRP-dependent cotranslational protein targeting to membrane";"mTORC1-mediated signalling";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"Ribosomal scanning and start codon recognition";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit"
Medex_00042981-RA	7	Reactome: R-HSA-389661;KEGG: 00020+1.2.4.1;Reactome: R-HSA-70268;Reactome: R-HSA-204174;KEGG: 00620+1.2.4.1;KEGG: 00010+1.2.4.1;Reactome: R-HSA-5362517	"Glyoxylate metabolism and glycine degradation";"Citrate cycle (TCA cycle)";"Pyruvate metabolism";"Regulation of pyruvate dehydrogenase (PDH) complex";"Pyruvate metabolism";"Glycolysis / Gluconeogenesis";"Signaling by Retinoic Acid"
Medex_00054281-RA	9	MetaCyc: PWY-5675;KEGG: 00250+6.3.1.2;MetaCyc: PWY-6549;MetaCyc: PWY-6964;KEGG: 00910+6.3.1.2;KEGG: 00630+6.3.1.2;MetaCyc: PWY-381;MetaCyc: PWY-6963;KEGG: 00220+6.3.1.2	"Nitrate reduction V (assimilatory)";"Alanine, aspartate and glutamate metabolism";"L-glutamine biosynthesis III";"Ammonia assimilation cycle II";"Nitrogen metabolism";"Glyoxylate and dicarboxylate metabolism";"Nitrate reduction II (assimilatory)";"Ammonia assimilation cycle I";"Arginine biosynthesis"
Medex_00047433-RA	6	Reactome: R-HSA-72649;Reactome: R-HSA-72702;Reactome: R-HSA-72695;Reactome: R-HSA-156827;Reactome: R-HSA-72706;Reactome: R-HSA-72689	"Translation initiation complex formation";"Ribosomal scanning and start codon recognition";"Formation of the ternary complex, and subsequently, the 43S complex";"L13a-mediated translational silencing of Ceruloplasmin expression";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Formation of a pool of free 40S subunits"
Medex_00022720-RA	2	Reactome: R-HSA-381340;Reactome: R-HSA-1989781	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression"
Medex_00063724-RA	1	Reactome: R-HSA-1660499	"Synthesis of PIPs at the plasma membrane"
Medex_00093582-RA	26	Reactome: R-HSA-5617472;Reactome: R-HSA-918233;Reactome: R-HSA-3371568;Reactome: R-HSA-9018519;Reactome: R-HSA-1368082;Reactome: R-HSA-3899300;Reactome: R-HSA-2894862;Reactome: R-HSA-933541;Reactome: R-HSA-5621575;Reactome: R-HSA-9614657;Reactome: R-HSA-8866907;Reactome: R-HSA-1234158;Reactome: R-HSA-381340;Reactome: R-HSA-2122947;Reactome: R-HSA-9013695;Reactome: R-HSA-210744;Reactome: R-HSA-1989781;Reactome: R-HSA-400253;Reactome: R-HSA-1912408;Reactome: R-HSA-3214847;Reactome: R-HSA-201722;Reactome: R-HSA-9013508;Reactome: R-HSA-9617629;Reactome: R-HSA-2644606;Reactome: R-HSA-8941856;Reactome: R-HSA-3134973	"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"TRAF3-dependent IRF activation pathway";"Attenuation phase";"Estrogen-dependent gene expression";"RORA activates gene expression";"SUMOylation of transcription cofactors";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"TRAF6 mediated IRF7 activation";"CD209 (DC-SIGN) signaling";"FOXO-mediated transcription of cell death genes";"Activation of the TFAP2 (AP-2) family of transcription factors";"Regulation of gene expression by Hypoxia-inducible Factor";"Transcriptional regulation of white adipocyte differentiation";"NOTCH1 Intracellular Domain Regulates Transcription";"NOTCH4 Intracellular Domain Regulates Transcription";"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"PPARA activates gene expression";"Circadian Clock";"Pre-NOTCH Transcription and Translation";"HATs acetylate histones";"Formation of the beta-catenin:TCF transactivating complex";"NOTCH3 Intracellular Domain Regulates Transcription";"Regulation of FOXO transcriptional activity by acetylation";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"RUNX3 regulates NOTCH signaling";"LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production"
Medex_00053686-RA	3	Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-212436	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"Generic Transcription Pathway"
Medex_00092689-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Medex_00078815-RA	6	MetaCyc: PWY-5884;Reactome: R-HSA-9640463;MetaCyc: PWY-6733;MetaCyc: PWY-7782;MetaCyc: PWY-7656;KEGG: 00073+1.2.1.84	"Wax esters biosynthesis I";"Wax biosynthesis";"Sporopollenin precursors biosynthesis";"Plasmalogen biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Cutin, suberine and wax biosynthesis"
Medex_00086348-RA	16	Reactome: R-HSA-975957;Reactome: R-HSA-9633012;Reactome: R-HSA-1799339;Reactome: R-HSA-72764;Reactome: R-HSA-975956;Reactome: R-HSA-72706;Reactome: R-HSA-6791226;Reactome: R-HSA-72702;Reactome: R-HSA-192823;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-156902;Reactome: R-HSA-72695;Reactome: R-HSA-72649;Reactome: R-HSA-72689;Reactome: R-HSA-2408557	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"SRP-dependent cotranslational protein targeting to membrane";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Major pathway of rRNA processing in the nucleolus and cytosol";"Ribosomal scanning and start codon recognition";"Viral mRNA Translation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Peptide chain elongation";"Formation of the ternary complex, and subsequently, the 43S complex";"Translation initiation complex formation";"Formation of a pool of free 40S subunits";"Selenocysteine synthesis"
Medex_00002177-RA	2	Reactome: R-HSA-380270;Reactome: R-HSA-380320	"Recruitment of mitotic centrosome proteins and complexes";"Recruitment of NuMA to mitotic centrosomes"
Medex_00092530-RA	6	Reactome: R-HSA-6791226;Reactome: R-HSA-450385;Reactome: R-HSA-450513;Reactome: R-HSA-450604;Reactome: R-HSA-380994;Reactome: R-HSA-429958	"Major pathway of rRNA processing in the nucleolus and cytosol";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"KSRP (KHSRP) binds and destabilizes mRNA";"ATF4 activates genes in response to endoplasmic reticulum stress";"mRNA decay by 3' to 5' exoribonuclease"
Medex_00040904-RA	2	Reactome: R-HSA-167826;Reactome: R-HSA-167827	"The fatty acid cycling model";"The proton buffering model"
Medex_00095411-RA	1	Reactome: R-HSA-4615885	"SUMOylation of DNA replication proteins"
Medex_00054916-RA	16	Reactome: R-HSA-2408557;Reactome: R-HSA-72689;Reactome: R-HSA-72649;Reactome: R-HSA-72695;Reactome: R-HSA-156902;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-192823;Reactome: R-HSA-72702;Reactome: R-HSA-6791226;Reactome: R-HSA-72706;Reactome: R-HSA-975956;Reactome: R-HSA-72764;Reactome: R-HSA-1799339;Reactome: R-HSA-9633012;Reactome: R-HSA-975957	"Selenocysteine synthesis";"Formation of a pool of free 40S subunits";"Translation initiation complex formation";"Formation of the ternary complex, and subsequently, the 43S complex";"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Viral mRNA Translation";"Ribosomal scanning and start codon recognition";"Major pathway of rRNA processing in the nucleolus and cytosol";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"SRP-dependent cotranslational protein targeting to membrane";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
Medex_00013947-RA	56	Reactome: R-HSA-4641257;Reactome: R-HSA-174113;Reactome: R-HSA-69481;Reactome: R-HSA-5678895;Reactome: R-HSA-350562;Reactome: R-HSA-8948751;Reactome: R-HSA-68827;Reactome: R-HSA-9604323;Reactome: R-HSA-5676590;Reactome: R-HSA-5362768;Reactome: R-HSA-1234176;Reactome: R-HSA-69017;Reactome: R-HSA-69601;Reactome: R-HSA-174184;Reactome: R-HSA-5607764;Reactome: R-HSA-174154;Reactome: R-HSA-1169091;Reactome: R-HSA-2871837;Reactome: R-HSA-8951664;Reactome: R-HSA-174084;Reactome: R-HSA-187577;Reactome: R-HSA-8854050;Reactome: R-HSA-1236974;Reactome: R-HSA-5610783;Reactome: R-HSA-195253;Reactome: R-HSA-75815;Reactome: R-HSA-8939902;Reactome: R-HSA-4608870;Reactome: R-HSA-5689603;Reactome: R-HSA-5668541;Reactome: R-HSA-5687128;Reactome: R-HSA-5689880;Reactome: R-HSA-5610785;Reactome: R-HSA-180534;Reactome: R-HSA-1236978;Reactome: R-HSA-349425;Reactome: R-HSA-5632684;Reactome: R-HSA-174178;Reactome: R-HSA-8852276;Reactome: R-HSA-5610780;Reactome: R-HSA-5607761;Reactome: R-HSA-202424;Reactome: R-HSA-983168;Reactome: R-HSA-8941858;Reactome: R-HSA-5358346;Reactome: R-HSA-5658442;Reactome: R-HSA-9020702;Reactome: R-HSA-450408;Reactome: R-HSA-180585;Reactome: R-HSA-2467813;Reactome: R-HSA-4641258;Reactome: R-HSA-382556;Reactome: R-HSA-68949;Reactome: R-HSA-211733;Reactome: R-HSA-8939236;Reactome: R-HSA-9010553	"Degradation of AXIN";"SCF-beta-TrCP mediated degradation of Emi1";"G2/M Checkpoints";"Defective CFTR causes cystic fibrosis";"Regulation of ornithine decarboxylase (ODC)";"Regulation of PTEN stability and activity";"CDT1 association with the CDC6:ORC:origin complex";"Negative regulation of NOTCH4 signaling";"NIK-->noncanonical NF-kB signaling";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"CDK-mediated phosphorylation and removal of Cdc6";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"CLEC7A (Dectin-1) signaling";"APC/C:Cdc20 mediated degradation of Securin";"Activation of NF-kappaB in B cells";"FCERI mediated NF-kB activation";"Neddylation";"Autodegradation of Cdh1 by Cdh1:APC/C";"SCF(Skp2)-mediated degradation of p27/p21";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"ER-Phagosome pathway";"Degradation of GLI2 by the proteasome";"Degradation of beta-catenin by the destruction complex";"Ubiquitin-dependent degradation of Cyclin D";"Regulation of RUNX2 expression and activity";"Asymmetric localization of PCP proteins";"UCH proteinases";"TNFR2 non-canonical NF-kB pathway";"MAPK6/MAPK4 signaling";"Ub-specific processing proteases";"GLI3 is processed to GLI3R by the proteasome";"Vpu mediated degradation of CD4";"Cross-presentation of soluble exogenous antigens (endosomes)";"Autodegradation of the E3 ubiquitin ligase COP1";"Hedgehog 'on' state";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Degradation of GLI1 by the proteasome";"Dectin-1 mediated noncanonical NF-kB signaling";"Downstream TCR signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Regulation of RUNX3 expression and activity";"Hedgehog ligand biogenesis";"Regulation of RAS by GAPs";"Interleukin-1 signaling";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Vif-mediated degradation of APOBEC3G";"Separation of Sister Chromatids";"Degradation of DVL";"ABC-family proteins mediated transport";"Orc1 removal from chromatin";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Regulation of expression of SLITs and ROBOs"
Medex_00102237-RA	11	Reactome: R-HSA-5693616;Reactome: R-HSA-5693554;Reactome: R-HSA-5685942;Reactome: R-HSA-5685938;Reactome: R-HSA-5693607;Reactome: R-HSA-5693568;Reactome: R-HSA-5358606;Reactome: R-HSA-5693579;Reactome: R-HSA-6804756;Reactome: R-HSA-69473;Reactome: R-HSA-5358565	"Presynaptic phase of homologous DNA pairing and strand exchange";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"HDR through Homologous Recombination (HRR)";"HDR through Single Strand Annealing (SSA)";"Processing of DNA double-strand break ends";"Resolution of D-loop Structures through Holliday Junction Intermediates";"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"Homologous DNA Pairing and Strand Exchange";"Regulation of TP53 Activity through Phosphorylation";"G2/M DNA damage checkpoint";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)"
Medex_00002447-RA	4	Reactome: R-HSA-5205685;Reactome: R-HSA-1632852;Reactome: R-HSA-8934903;Reactome: R-HSA-936440	"Pink/Parkin Mediated Mitophagy";"Macroautophagy";"Receptor Mediated Mitophagy";"Negative regulators of DDX58/IFIH1 signaling"
Medex_00011783-RA	3	Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-212436	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"Generic Transcription Pathway"
Medex_00050022-RA	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
Medex_00070396-RA	3	Reactome: R-HSA-5628897;KEGG: 00480+1.11.1.15;Reactome: R-HSA-3299685	"TP53 Regulates Metabolic Genes";"Glutathione metabolism";"Detoxification of Reactive Oxygen Species"
Medex_00008099-RA	6	Reactome: R-HSA-429958;Reactome: R-HSA-380994;Reactome: R-HSA-450604;Reactome: R-HSA-450513;Reactome: R-HSA-450385;Reactome: R-HSA-6791226	"mRNA decay by 3' to 5' exoribonuclease";"ATF4 activates genes in response to endoplasmic reticulum stress";"KSRP (KHSRP) binds and destabilizes mRNA";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"Major pathway of rRNA processing in the nucleolus and cytosol"
Medex_00018416-RA	27	Reactome: R-HSA-9609690;Reactome: R-HSA-4551638;Reactome: R-HSA-5619107;Reactome: R-HSA-9610379;Reactome: R-HSA-168325;Reactome: R-HSA-191859;Reactome: R-HSA-159236;Reactome: R-HSA-3108214;Reactome: R-HSA-6784531;Reactome: R-HSA-3232142;Reactome: R-HSA-3301854;Reactome: R-HSA-180910;Reactome: R-HSA-168271;Reactome: R-HSA-170822;Reactome: R-HSA-4570464;Reactome: R-HSA-4085377;Reactome: R-HSA-3371453;Reactome: R-HSA-4615885;Reactome: R-HSA-159230;Reactome: R-HSA-168276;Reactome: R-HSA-5578749;Reactome: R-HSA-165054;Reactome: R-HSA-1169408;Reactome: R-HSA-168333;Reactome: R-HSA-180746;Reactome: R-HSA-159227;Reactome: R-HSA-159231	"HCMV Early Events";"SUMOylation of chromatin organization proteins";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"HCMV Late Events";"Viral Messenger RNA Synthesis";"snRNP Assembly";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"SUMOylation of DNA damage response and repair proteins";"tRNA processing in the nucleus";"SUMOylation of ubiquitinylation proteins";"Nuclear Pore Complex (NPC) Disassembly";"Vpr-mediated nuclear import of PICs";"Transport of Ribonucleoproteins into the Host Nucleus";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"SUMOylation of RNA binding proteins";"SUMOylation of SUMOylation proteins";"Regulation of HSF1-mediated heat shock response";"SUMOylation of DNA replication proteins";"Transport of the SLBP Dependant Mature mRNA";"NS1 Mediated Effects on Host Pathways";"Transcriptional regulation by small RNAs";"Rev-mediated nuclear export of HIV RNA";"ISG15 antiviral mechanism";"NEP/NS2 Interacts with the Cellular Export Machinery";"Nuclear import of Rev protein";"Transport of the SLBP independent Mature mRNA";"Transport of Mature mRNA Derived from an Intronless Transcript"
Medex_00010413-RA	2	Reactome: R-HSA-196807;KEGG: 00760+6.3.1.5	"Nicotinate metabolism";"Nicotinate and nicotinamide metabolism"
Medex_00059152-RA	1	Reactome: R-HSA-8850843	"Phosphate bond hydrolysis by NTPDase proteins"
Medex_00070141-RA	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
Medex_00007476-RA	7	MetaCyc: PWY-5469;MetaCyc: PWY-6824;MetaCyc: PWY-5461;KEGG: 00940+1.11.1.7;MetaCyc: PWY-7445;MetaCyc: PWY-5466;MetaCyc: PWY-7214	"Sesamin biosynthesis";"Justicidin B biosynthesis";"Betanidin degradation";"Phenylpropanoid biosynthesis";"Luteolin triglucuronide degradation";"Matairesinol biosynthesis";"Baicalein degradation (hydrogen peroxide detoxification)"
Medex_00006772-RA	10	KEGG: 00604+3.2.1.23;MetaCyc: PWY-6807;KEGG: 00511+3.2.1.23;Reactome: R-HSA-2024096;Reactome: R-HSA-2206292;KEGG: 00600+3.2.1.23;Reactome: R-HSA-2160916;Reactome: R-HSA-6798695;KEGG: 00052+3.2.1.23;KEGG: 00531+3.2.1.23	"Glycosphingolipid biosynthesis - ganglio series";"Xyloglucan degradation II (exoglucanase)";"Other glycan degradation";"HS-GAG degradation";"MPS VII - Sly syndrome";"Sphingolipid metabolism";"Hyaluronan uptake and degradation";"Neutrophil degranulation";"Galactose metabolism";"Glycosaminoglycan degradation"
Medex_00067553-RA	3	MetaCyc: PWY-7511;Reactome: R-HSA-349425;Reactome: R-HSA-8951664	"Protein ubiquitination";"Autodegradation of the E3 ubiquitin ligase COP1";"Neddylation"
Medex_00100916-RA	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
Medex_00056953-RA	4	Reactome: R-HSA-189483;Reactome: R-HSA-382556;Reactome: R-HSA-5679001;MetaCyc: PWY-6972	"Heme degradation";"ABC-family proteins mediated transport";"Defective ABCC2 causes Dubin-Johnson syndrome";"Oleandomycin activation/inactivation"
Medex_00076373-RA	1	Reactome: R-HSA-380320	"Recruitment of NuMA to mitotic centrosomes"
Medex_00084172-RA	56	Reactome: R-HSA-8854050;Reactome: R-HSA-1236974;Reactome: R-HSA-5610783;Reactome: R-HSA-174084;Reactome: R-HSA-187577;Reactome: R-HSA-2871837;Reactome: R-HSA-8951664;Reactome: R-HSA-174184;Reactome: R-HSA-5607764;Reactome: R-HSA-174154;Reactome: R-HSA-1169091;Reactome: R-HSA-8948751;Reactome: R-HSA-9604323;Reactome: R-HSA-68827;Reactome: R-HSA-5676590;Reactome: R-HSA-1234176;Reactome: R-HSA-69601;Reactome: R-HSA-5362768;Reactome: R-HSA-69017;Reactome: R-HSA-4641257;Reactome: R-HSA-174113;Reactome: R-HSA-69481;Reactome: R-HSA-350562;Reactome: R-HSA-5678895;Reactome: R-HSA-8939236;Reactome: R-HSA-211733;Reactome: R-HSA-68949;Reactome: R-HSA-382556;Reactome: R-HSA-9010553;Reactome: R-HSA-450408;Reactome: R-HSA-180585;Reactome: R-HSA-2467813;Reactome: R-HSA-4641258;Reactome: R-HSA-9020702;Reactome: R-HSA-202424;Reactome: R-HSA-983168;Reactome: R-HSA-5358346;Reactome: R-HSA-8941858;Reactome: R-HSA-5658442;Reactome: R-HSA-174178;Reactome: R-HSA-8852276;Reactome: R-HSA-5610780;Reactome: R-HSA-5607761;Reactome: R-HSA-180534;Reactome: R-HSA-1236978;Reactome: R-HSA-349425;Reactome: R-HSA-5632684;Reactome: R-HSA-4608870;Reactome: R-HSA-5687128;Reactome: R-HSA-5668541;Reactome: R-HSA-5689603;Reactome: R-HSA-5610785;Reactome: R-HSA-5689880;Reactome: R-HSA-195253;Reactome: R-HSA-75815;Reactome: R-HSA-8939902	"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"ER-Phagosome pathway";"Degradation of GLI2 by the proteasome";"Autodegradation of Cdh1 by Cdh1:APC/C";"SCF(Skp2)-mediated degradation of p27/p21";"FCERI mediated NF-kB activation";"Neddylation";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"CLEC7A (Dectin-1) signaling";"APC/C:Cdc20 mediated degradation of Securin";"Activation of NF-kappaB in B cells";"Regulation of PTEN stability and activity";"Negative regulation of NOTCH4 signaling";"CDT1 association with the CDC6:ORC:origin complex";"NIK-->noncanonical NF-kB signaling";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"CDK-mediated phosphorylation and removal of Cdc6";"Degradation of AXIN";"SCF-beta-TrCP mediated degradation of Emi1";"G2/M Checkpoints";"Regulation of ornithine decarboxylase (ODC)";"Defective CFTR causes cystic fibrosis";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Orc1 removal from chromatin";"ABC-family proteins mediated transport";"Regulation of expression of SLITs and ROBOs";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Vif-mediated degradation of APOBEC3G";"Separation of Sister Chromatids";"Degradation of DVL";"Interleukin-1 signaling";"Downstream TCR signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Hedgehog ligand biogenesis";"Regulation of RUNX3 expression and activity";"Regulation of RAS by GAPs";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Degradation of GLI1 by the proteasome";"Dectin-1 mediated noncanonical NF-kB signaling";"Vpu mediated degradation of CD4";"Cross-presentation of soluble exogenous antigens (endosomes)";"Autodegradation of the E3 ubiquitin ligase COP1";"Hedgehog 'on' state";"Asymmetric localization of PCP proteins";"MAPK6/MAPK4 signaling";"TNFR2 non-canonical NF-kB pathway";"UCH proteinases";"GLI3 is processed to GLI3R by the proteasome";"Ub-specific processing proteases";"Degradation of beta-catenin by the destruction complex";"Ubiquitin-dependent degradation of Cyclin D";"Regulation of RUNX2 expression and activity"
Medex_00092952-RA	2	Reactome: R-HSA-8939243;Reactome: R-HSA-3214858	"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RMTs methylate histone arginines"
Medex_00051158-RA	6	MetaCyc: PWY-6733;MetaCyc: PWY-7782;MetaCyc: PWY-7656;KEGG: 00073+1.2.1.84;MetaCyc: PWY-5884;Reactome: R-HSA-9640463	"Sporopollenin precursors biosynthesis";"Plasmalogen biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax esters biosynthesis I";"Wax biosynthesis"
Medex_00084536-RA	26	Reactome: R-HSA-2132295;Reactome: R-HSA-5626467;Reactome: R-HSA-6811436;Reactome: R-HSA-9609690;Reactome: R-HSA-8955332;Reactome: R-HSA-6807878;Reactome: R-HSA-190840;Reactome: R-HSA-9619483;Reactome: R-HSA-190861;Reactome: R-HSA-437239;Reactome: R-HSA-8852276;Reactome: R-HSA-9609736;Reactome: R-HSA-983189;Reactome: R-HSA-3371497;Reactome: R-HSA-2500257;Reactome: R-HSA-380320;Reactome: R-HSA-1445148;Reactome: R-HSA-389960;Reactome: R-HSA-5663220;Reactome: R-HSA-389977;Reactome: R-HSA-68877;Reactome: R-HSA-6811434;Reactome: R-HSA-9648025;Reactome: R-HSA-9646399;Reactome: R-HSA-5617833;Reactome: R-HSA-2467813	"MHC class II antigen presentation";"RHO GTPases activate IQGAPs";"COPI-independent Golgi-to-ER retrograde traffic";"HCMV Early Events";"Carboxyterminal post-translational modifications of tubulin";"COPI-mediated anterograde transport";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Activation of AMPK downstream of NMDARs";"Gap junction assembly";"Recycling pathway of L1";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Assembly and cell surface presentation of NMDA receptors";"Kinesins";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Resolution of Sister Chromatid Cohesion";"Recruitment of NuMA to mitotic centrosomes";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Formation of tubulin folding intermediates by CCT/TriC";"RHO GTPases Activate Formins";"Post-chaperonin tubulin folding pathway";"Mitotic Prometaphase";"COPI-dependent Golgi-to-ER retrograde traffic";"EML4 and NUDC in mitotic spindle formation";"Aggrephagy";"Cilium Assembly";"Separation of Sister Chromatids"
Medex_00009879-RA	7	KEGG: 00230+3.6.1.15;MetaCyc: PWY-7210;MetaCyc: PWY-7198;MetaCyc: PWY-6545;MetaCyc: PWY-7185;KEGG: 00730+3.6.1.15;MetaCyc: PWY-7184	"Purine metabolism";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"UTP and CTP dephosphorylation I";"Thiamine metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis I"
Medex_00033046-RA	6	MetaCyc: PWY-5884;Reactome: R-HSA-9640463;KEGG: 00073+1.2.1.84;MetaCyc: PWY-7782;MetaCyc: PWY-7656;MetaCyc: PWY-6733	"Wax esters biosynthesis I";"Wax biosynthesis";"Cutin, suberine and wax biosynthesis";"Plasmalogen biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Sporopollenin precursors biosynthesis"
Medex_00017046-RA	2	Reactome: R-HSA-2032785;Reactome: R-HSA-8951671	"YAP1- and WWTR1 (TAZ)-stimulated gene expression";"RUNX3 regulates YAP1-mediated transcription"
Medex_00023865-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Medex_00006535-RA	2	Reactome: R-HSA-4090294;Reactome: R-HSA-383280	"SUMOylation of intracellular receptors";"Nuclear Receptor transcription pathway"
Medex_00076741-RA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
Medex_00023401-RA	2	Reactome: R-HSA-1483191;Reactome: R-HSA-425366	"Synthesis of PC";"Transport of bile salts and organic acids, metal ions and amine compounds"
Medex_00077773-RA	6	Reactome: R-HSA-6785470;MetaCyc: PWY-6829;Reactome: R-HSA-8868766;MetaCyc: PWY-7286;Reactome: R-HSA-6787450;MetaCyc: PWY-7285	"tRNA processing in the mitochondrion";"Trna methylation (yeast)";"rRNA processing in the mitochondrion";"7-(3-amino-3-carboxypropyl)-wyosine biosynthesis";"tRNA modification in the mitochondrion";"Methylwyosine biosynthesis"
Medex_00059905-RA	4	Reactome: R-HSA-446199;KEGG: 00510+2.7.1.108;Reactome: R-HSA-4755583;MetaCyc: PWY-6129	"Synthesis of Dolichyl-phosphate";"N-Glycan biosynthesis";"Defective DOLK causes DOLK-CDG (CDG-1m)";"Dolichol and dolichyl phosphate biosynthesis"
Medex_00016197-RA	2	Reactome: R-HSA-1236974;Reactome: R-HSA-1799339	"ER-Phagosome pathway";"SRP-dependent cotranslational protein targeting to membrane"
Medex_00044798-RA	1	Reactome: R-HSA-2022377	"Metabolism of Angiotensinogen to Angiotensins"
Medex_00072930-RA	6	Reactome: R-HSA-8951664;Reactome: R-HSA-3769402;Reactome: R-HSA-3214841;Reactome: R-HSA-8936459;Reactome: R-HSA-201722;Reactome: R-HSA-5617472	"Neddylation";"Deactivation of the beta-catenin transactivating complex";"PKMTs methylate histone lysines";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Formation of the beta-catenin:TCF transactivating complex";"Activation of anterior HOX genes in hindbrain development during early embryogenesis"
Medex_00028733-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00001743-RA	6	MetaCyc: PWY-7656;MetaCyc: PWY-7782;MetaCyc: PWY-6733;KEGG: 00073+1.2.1.84;MetaCyc: PWY-5884;Reactome: R-HSA-9640463	"Spodoptera littoralis pheromone biosynthesis";"Plasmalogen biosynthesis";"Sporopollenin precursors biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax esters biosynthesis I";"Wax biosynthesis"
Medex_00091573-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00015580-RA	6	Reactome: R-HSA-69052;Reactome: R-HSA-68949;Reactome: R-HSA-68867;Reactome: R-HSA-68962;Reactome: R-HSA-176974;Reactome: R-HSA-176187	"Switching of origins to a post-replicative state";"Orc1 removal from chromatin";"Assembly of the pre-replicative complex";"Activation of the pre-replicative complex";"Unwinding of DNA";"Activation of ATR in response to replication stress"
Medex_00083591-RA	3	KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16	"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
Medex_00016120-RA	1	Reactome: R-HSA-5620922	"BBSome-mediated cargo-targeting to cilium"
Medex_00036876-RA	1	Reactome: R-HSA-198933	"Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"
Medex_00063700-RA	1	KEGG: 00480+3.4.11.2	"Glutathione metabolism"
Medex_00030901-RA	6	Reactome: R-HSA-6798695;KEGG: 00630+1.11.1.6;Reactome: R-HSA-9033241;KEGG: 00380+1.11.1.6;Reactome: R-HSA-9615017;Reactome: R-HSA-3299685	"Neutrophil degranulation";"Glyoxylate and dicarboxylate metabolism";"Peroxisomal protein import";"Tryptophan metabolism";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"Detoxification of Reactive Oxygen Species"
Medex_00067586-RA	8	Reactome: R-HSA-5610787;Reactome: R-HSA-432040;Reactome: R-HSA-180024;Reactome: R-HSA-164378;Reactome: R-HSA-163615;Reactome: R-HSA-381676;Reactome: R-HSA-442720;Reactome: R-HSA-983231	"Hedgehog 'off' state";"Vasopressin regulates renal water homeostasis via Aquaporins";"DARPP-32 events";"PKA activation in glucagon signalling";"PKA activation";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"CREB1 phosphorylation through the activation of Adenylate Cyclase";"Factors involved in megakaryocyte development and platelet production"
Medex_00054240-RA	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
Medex_00036844-RA	1	Reactome: R-HSA-202733	"Cell surface interactions at the vascular wall"
Medex_00071933-RA	11	Reactome: R-HSA-983231;Reactome: R-HSA-5663213;Reactome: R-HSA-69231;KEGG: 04660+2.7.10.2;Reactome: R-HSA-428890;Reactome: R-HSA-5685938;Reactome: R-HSA-8939236;Reactome: R-HSA-8940973;Reactome: R-HSA-5693565;Reactome: R-HSA-2029482;Reactome: R-HSA-525793	"Factors involved in megakaryocyte development and platelet production";"RHO GTPases Activate WASPs and WAVEs";"Cyclin D associated events in G1";"T cell receptor signaling pathway";"Role of ABL in ROBO-SLIT signaling";"HDR through Single Strand Annealing (SSA)";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"RUNX2 regulates osteoblast differentiation";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Regulation of actin dynamics for phagocytic cup formation";"Myogenesis"
Medex_00068821-RA	1	Reactome: R-HSA-211981	"Xenobiotics"
Medex_00057786-RA	2	Reactome: R-HSA-5682910;Reactome: R-HSA-5250971	"LGI-ADAM interactions";"Toxicity of botulinum toxin type C (BoNT/C)"
Medex_00086133-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Medex_00025308-RA	3	KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway"
Medex_00031452-RA	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
Medex_00063576-RA	1	Reactome: R-HSA-1799339	"SRP-dependent cotranslational protein targeting to membrane"
Medex_00084082-RA	3	Reactome: R-HSA-429947;Reactome: R-HSA-5617472;Reactome: R-HSA-6804115	"Deadenylation of mRNA";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"
Medex_00005595-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Medex_00073984-RA	9	MetaCyc: PWY-6703;MetaCyc: PWY-7852;MetaCyc: PWY-6983;Reactome: R-HSA-1474151;MetaCyc: PWY-5663;MetaCyc: PWY-6147;MetaCyc: PWY-7442;MetaCyc: PWY-5664;KEGG: 00790+3.5.4.16	"Preq0 biosynthesis";"6-hydroxymethyl-dihydropterin diphosphate biosynthesis IV (Plasmodium)";"Threo-tetrahydrobiopterin biosynthesis";"Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation";"Erythro-tetrahydrobiopterin biosynthesis I";"6-hydroxymethyl-dihydropterin diphosphate biosynthesis I";"Drosopterin and aurodrosopterin biosynthesis";"Erythro-tetrahydrobiopterin biosynthesis II";"Folate biosynthesis"
Medex_00060493-RA	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
Medex_00051471-RA	3	KEGG: 00790+3.1.3.1;MetaCyc: PWY-5491;KEGG: 00730+3.1.3.1	"Folate biosynthesis";"Diethylphosphate degradation";"Thiamine metabolism"
Medex_00006007-RA	3	Reactome: R-HSA-110320;Reactome: R-HSA-5656169;Reactome: R-HSA-5685942	"Translesion Synthesis by POLH";"Termination of translesion DNA synthesis";"HDR through Homologous Recombination (HRR)"
Medex_00025544-RA	2	KEGG: 00270+3.3.1.1;MetaCyc: PWY-5041	"Cysteine and methionine metabolism";"S-adenosyl-L-methionine cycle II"
Medex_00026026-RA	1	KEGG: 00970+6.3.5.7	"Aminoacyl-tRNA biosynthesis"
Medex_00065443-RA	8	KEGG: 00051+2.7.1.1;KEGG: 00010+2.7.1.1;KEGG: 00524+2.7.1.1;KEGG: 00500+2.7.1.1;KEGG: 00521+2.7.1.1;KEGG: 00052+2.7.1.1;Reactome: R-HSA-70171;KEGG: 00520+2.7.1.1	"Fructose and mannose metabolism";"Glycolysis / Gluconeogenesis";"Neomycin, kanamycin and gentamicin biosynthesis";"Starch and sucrose metabolism";"Streptomycin biosynthesis";"Galactose metabolism";"Glycolysis";"Amino sugar and nucleotide sugar metabolism"
Medex_00099881-RA	7	KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1	"Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Human papillomavirus infection";"Relaxin signaling pathway";"Thermogenesis";"Human cytomegalovirus infection"
Medex_00042049-RA	1	Reactome: R-HSA-5663220	"RHO GTPases Activate Formins"
Medex_00032104-RA	4	Reactome: R-HSA-9646399;Reactome: R-HSA-9615710;Reactome: R-HSA-9613829;Reactome: R-HSA-3899300	"Aggrephagy";"Late endosomal microautophagy";"Chaperone Mediated Autophagy";"SUMOylation of transcription cofactors"
Medex_00037681-RA	3	Reactome: R-HSA-193648;Reactome: R-HSA-194840;Reactome: R-HSA-416482	"NRAGE signals death through JNK";"Rho GTPase cycle";"G alpha (12/13) signalling events"
Medex_00009925-RA	7	Reactome: R-HSA-73980;Reactome: R-HSA-76071;Reactome: R-HSA-76061;Reactome: R-HSA-1834949;Reactome: R-HSA-73780;Reactome: R-HSA-749476;Reactome: R-HSA-76066	"RNA Polymerase III Transcription Termination";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Chain Elongation";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 2 Promoter"
Medex_00008832-RA	1	Reactome: R-HSA-9633012	"Response of EIF2AK4 (GCN2) to amino acid deficiency"
Medex_00008374-RA	1	Reactome: R-HSA-352230	"Amino acid transport across the plasma membrane"
Medex_00028436-RA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00029444-RA	12	MetaCyc: PWY-8053;MetaCyc: PWY-7417;KEGG: 00591+3.1.1.4;MetaCyc: PWY-7409;MetaCyc: PWY-8051;MetaCyc: PWY-6803;KEGG: 00590+3.1.1.4;KEGG: 00565+3.1.1.4;MetaCyc: PWY-7416;MetaCyc: PWY-7783;KEGG: 00592+3.1.1.4;KEGG: 00564+3.1.1.4	"Anandamide biosynthesis II";"Phospholipid remodeling (phosphatidate, yeast)";"Linoleic acid metabolism";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Anandamide biosynthesis I";"Phosphatidylcholine acyl editing";"Arachidonic acid metabolism";"Ether lipid metabolism";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Plasmalogen degradation";"alpha-Linolenic acid metabolism";"Glycerophospholipid metabolism"
Medex_00048174-RA	1	Reactome: R-HSA-2470946	"Cohesin Loading onto Chromatin"
Medex_00053978-RA	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
Medex_00004447-RA	3	KEGG: 00730+3.1.3.2;KEGG: 00740+3.1.3.2;MetaCyc: PWY-6348	"Thiamine metabolism";"Riboflavin metabolism";"Phosphate acquisition"
Medex_00077136-RA	1	Reactome: R-HSA-3108214	"SUMOylation of DNA damage response and repair proteins"
Medex_00064916-RA	58	Reactome: R-HSA-5658442;Reactome: R-HSA-5358346;Reactome: R-HSA-8941858;Reactome: R-HSA-983168;Reactome: R-HSA-202424;Reactome: R-HSA-9020702;Reactome: R-HSA-6798695;Reactome: R-HSA-4641258;Reactome: R-HSA-2467813;Reactome: R-HSA-5689901;Reactome: R-HSA-180585;Reactome: R-HSA-450408;Reactome: R-HSA-9010553;Reactome: R-HSA-382556;Reactome: R-HSA-8939236;Reactome: R-HSA-68949;Reactome: R-HSA-211733;Reactome: R-HSA-8939902;Reactome: R-HSA-75815;Reactome: R-HSA-195253;Reactome: R-HSA-5610785;Reactome: R-HSA-5689880;Reactome: R-HSA-5689603;Reactome: R-HSA-5668541;Reactome: R-HSA-5687128;Reactome: R-HSA-4608870;Reactome: R-HSA-5632684;Reactome: R-HSA-1236978;Reactome: R-HSA-349425;Reactome: R-HSA-180534;Reactome: R-HSA-5607761;Reactome: R-HSA-5610780;Reactome: R-HSA-8852276;Reactome: R-HSA-174178;Reactome: R-HSA-187577;Reactome: R-HSA-174084;Reactome: R-HSA-5610783;Reactome: R-HSA-1236974;Reactome: R-HSA-8854050;Reactome: R-HSA-69481;Reactome: R-HSA-350562;Reactome: R-HSA-5678895;Reactome: R-HSA-174113;Reactome: R-HSA-4641257;Reactome: R-HSA-1234176;Reactome: R-HSA-69601;Reactome: R-HSA-5362768;Reactome: R-HSA-69017;Reactome: R-HSA-5676590;Reactome: R-HSA-8948751;Reactome: R-HSA-9604323;Reactome: R-HSA-68827;Reactome: R-HSA-1169091;Reactome: R-HSA-174154;Reactome: R-HSA-5607764;Reactome: R-HSA-174184;Reactome: R-HSA-8951664;Reactome: R-HSA-2871837	"Regulation of RAS by GAPs";"Hedgehog ligand biogenesis";"Regulation of RUNX3 expression and activity";"Antigen processing: Ubiquitination & Proteasome degradation";"Downstream TCR signaling";"Interleukin-1 signaling";"Neutrophil degranulation";"Degradation of DVL";"Separation of Sister Chromatids";"Metalloprotease DUBs";"Vif-mediated degradation of APOBEC3G";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Regulation of expression of SLITs and ROBOs";"ABC-family proteins mediated transport";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Orc1 removal from chromatin";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Regulation of RUNX2 expression and activity";"Ubiquitin-dependent degradation of Cyclin D";"Degradation of beta-catenin by the destruction complex";"GLI3 is processed to GLI3R by the proteasome";"Ub-specific processing proteases";"UCH proteinases";"TNFR2 non-canonical NF-kB pathway";"MAPK6/MAPK4 signaling";"Asymmetric localization of PCP proteins";"Hedgehog 'on' state";"Cross-presentation of soluble exogenous antigens (endosomes)";"Autodegradation of the E3 ubiquitin ligase COP1";"Vpu mediated degradation of CD4";"Dectin-1 mediated noncanonical NF-kB signaling";"Degradation of GLI1 by the proteasome";"The role of GTSE1 in G2/M progression after G2 checkpoint";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"SCF(Skp2)-mediated degradation of p27/p21";"Autodegradation of Cdh1 by Cdh1:APC/C";"Degradation of GLI2 by the proteasome";"ER-Phagosome pathway";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"G2/M Checkpoints";"Regulation of ornithine decarboxylase (ODC)";"Defective CFTR causes cystic fibrosis";"SCF-beta-TrCP mediated degradation of Emi1";"Degradation of AXIN";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"CDK-mediated phosphorylation and removal of Cdc6";"NIK-->noncanonical NF-kB signaling";"Regulation of PTEN stability and activity";"Negative regulation of NOTCH4 signaling";"CDT1 association with the CDC6:ORC:origin complex";"Activation of NF-kappaB in B cells";"APC/C:Cdc20 mediated degradation of Securin";"CLEC7A (Dectin-1) signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Neddylation";"FCERI mediated NF-kB activation"
Medex_00034653-RA	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
Medex_00031810-RA	1	Reactome: R-HSA-5620912	"Anchoring of the basal body to the plasma membrane"
Medex_00080561-RA	4	Reactome: R-HSA-350054;Reactome: R-HSA-2894862;Reactome: R-HSA-2644606;Reactome: R-HSA-2122947	"Notch-HLH transcription pathway";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH1 Intracellular Domain Regulates Transcription"
Medex_00054632-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Medex_00051686-RA	13	Reactome: R-HSA-975957;Reactome: R-HSA-192823;Reactome: R-HSA-1799339;Reactome: R-HSA-9633012;Reactome: R-HSA-156902;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-72706;Reactome: R-HSA-975956;Reactome: R-HSA-72689;Reactome: R-HSA-72764;Reactome: R-HSA-2408557;Reactome: R-HSA-6791226	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Viral mRNA Translation";"SRP-dependent cotranslational protein targeting to membrane";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Formation of a pool of free 40S subunits";"Eukaryotic Translation Termination";"Selenocysteine synthesis";"Major pathway of rRNA processing in the nucleolus and cytosol"
Medex_00072476-RA	1	Reactome: R-HSA-1655829	"Regulation of cholesterol biosynthesis by SREBP (SREBF)"
Medex_00060716-RA	1	Reactome: R-HSA-1474228	"Degradation of the extracellular matrix"
Medex_00000065-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Medex_00073586-RA	1	Reactome: R-HSA-2129379	"Molecules associated with elastic fibres"
Medex_00022684-RA	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
Medex_00025292-RA	17	Reactome: R-HSA-450321;Reactome: R-HSA-5689880;Reactome: R-HSA-9645460;Reactome: R-HSA-445989;Reactome: R-HSA-9014325;Reactome: R-HSA-2871837;Reactome: R-HSA-450302;Reactome: R-HSA-4086398;Reactome: R-HSA-937042;Reactome: R-HSA-5607764;Reactome: R-HSA-1169091;Reactome: R-HSA-975163;Reactome: R-HSA-9020702;Reactome: R-HSA-202424;Reactome: R-HSA-5357956;Reactome: R-HSA-937072;Reactome: R-HSA-168638	"JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1";"Ub-specific processing proteases";"Alpha-protein kinase 1 signaling pathway";"TAK1 activates NFkB by phosphorylation and activation of IKKs complex";"TICAM1,TRAF6-dependent induction of TAK1 complex";"FCERI mediated NF-kB activation";"activated TAK1 mediates p38 MAPK activation";"Ca2+ pathway";"IRAK2 mediated activation of TAK1 complex";"CLEC7A (Dectin-1) signaling";"Activation of NF-kappaB in B cells";"IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation";"Interleukin-1 signaling";"Downstream TCR signaling";"TNFR1-induced NFkappaB signaling pathway";"TRAF6-mediated induction of TAK1 complex within TLR4 complex";"NOD1/2 Signaling Pathway"
Medex_00060139-RA	2	Reactome: R-HSA-9610379;Reactome: R-HSA-917729	"HCMV Late Events";"Endosomal Sorting Complex Required For Transport (ESCRT)"
Medex_00067545-RA	10	KEGG: 05165+2.7.1.153;Reactome: R-HSA-1660499;KEGG: 05170+2.7.1.153;Reactome: R-HSA-9027276;KEGG: 04151+2.7.1.153;KEGG: 04070+2.7.1.153;KEGG: 05163+2.7.1.153;KEGG: 00562+2.7.1.153;MetaCyc: PWY-6352;KEGG: 04150+2.7.1.153	"Human papillomavirus infection";"Synthesis of PIPs at the plasma membrane";"Human immunodeficiency virus 1 infection";"Erythropoietin activates Phosphoinositide-3-kinase (PI3K)";"PI3K-Akt signaling pathway";"Phosphatidylinositol signaling system";"Human cytomegalovirus infection";"Inositol phosphate metabolism";"3-phosphoinositide biosynthesis";"mTOR signaling pathway"
Medex_00009627-RA	1	Reactome: R-HSA-6811436	"COPI-independent Golgi-to-ER retrograde traffic"
Medex_00030920-RA	1	Reactome: R-HSA-400253	"Circadian Clock"
Medex_00024942-RA	10	KEGG: 00010+5.3.1.1;KEGG: 00051+5.3.1.1;MetaCyc: PWY-5484;Reactome: R-HSA-70171;Reactome: R-HSA-70263;KEGG: 00710+5.3.1.1;KEGG: 00562+5.3.1.1;MetaCyc: PWY-7003;MetaCyc: PWY-6142;MetaCyc: PWY-1042	"Glycolysis / Gluconeogenesis";"Fructose and mannose metabolism";"Glycolysis II (from fructose 6-phosphate)";"Glycolysis";"Gluconeogenesis";"Carbon fixation in photosynthetic organisms";"Inositol phosphate metabolism";"Glycerol degradation to butanol";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Glycolysis IV (plant cytosol)"
Medex_00076465-RA	18	Reactome: R-HSA-9633012;Reactome: R-HSA-1799339;Reactome: R-HSA-166208;Reactome: R-HSA-975957;Reactome: R-HSA-6791226;Reactome: R-HSA-72702;Reactome: R-HSA-72764;Reactome: R-HSA-72706;Reactome: R-HSA-975956;Reactome: R-HSA-72695;Reactome: R-HSA-156902;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-72649;Reactome: R-HSA-192823;Reactome: R-HSA-2408557;Reactome: R-HSA-6790901;Reactome: R-HSA-72689	"Response of EIF2AK4 (GCN2) to amino acid deficiency";"SRP-dependent cotranslational protein targeting to membrane";"mTORC1-mediated signalling";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"Ribosomal scanning and start codon recognition";"Eukaryotic Translation Termination";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Formation of the ternary complex, and subsequently, the 43S complex";"Peptide chain elongation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Translation initiation complex formation";"Viral mRNA Translation";"Selenocysteine synthesis";"rRNA modification in the nucleus and cytosol";"Formation of a pool of free 40S subunits"
Medex_00094075-RA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
Medex_00091252-RA	8	Reactome: R-HSA-380972;Reactome: R-HSA-3371571;Reactome: R-HSA-166208;Reactome: R-HSA-1632852;Reactome: R-HSA-165159;Reactome: R-HSA-9639288;Reactome: R-HSA-5628897;Reactome: R-HSA-8943724	"Energy dependent regulation of mTOR by LKB1-AMPK";"HSF1-dependent transactivation";"mTORC1-mediated signalling";"Macroautophagy";"mTOR signalling";"Amino acids regulate mTORC1";"TP53 Regulates Metabolic Genes";"Regulation of PTEN gene transcription"
Medex_00019556-RA	1	KEGG: 00480+3.4.11.2	"Glutathione metabolism"
Medex_00015974-RA	20	Reactome: R-HSA-9639288;KEGG: 04150+2.7.11.1;Reactome: R-HSA-1257604;KEGG: 04714+2.7.11.1;Reactome: R-HSA-3371571;KEGG: 04151+2.7.11.1;Reactome: R-HSA-389357;Reactome: R-HSA-5628897;Reactome: R-HSA-5674400;Reactome: R-HSA-5218920;KEGG: 05163+2.7.11.1;Reactome: R-HSA-166208;KEGG: 05170+2.7.11.1;Reactome: R-HSA-165159;Reactome: R-HSA-1632852;KEGG: 05165+2.7.11.1;Reactome: R-HSA-380972;Reactome: R-HSA-8943724;KEGG: 04926+2.7.11.1;Reactome: R-HSA-6804757	"Amino acids regulate mTORC1";"mTOR signaling pathway";"PIP3 activates AKT signaling";"Thermogenesis";"HSF1-dependent transactivation";"PI3K-Akt signaling pathway";"CD28 dependent PI3K/Akt signaling";"TP53 Regulates Metabolic Genes";"Constitutive Signaling by AKT1 E17K in Cancer";"VEGFR2 mediated vascular permeability";"Human cytomegalovirus infection";"mTORC1-mediated signalling";"Human immunodeficiency virus 1 infection";"mTOR signalling";"Macroautophagy";"Human papillomavirus infection";"Energy dependent regulation of mTOR by LKB1-AMPK";"Regulation of PTEN gene transcription";"Relaxin signaling pathway";"Regulation of TP53 Degradation"
Medex_00018270-RA	3	KEGG: 00790+2.10.1.1;Reactome: R-HSA-947581;MetaCyc: PWY-6823	"Folate biosynthesis";"Molybdenum cofactor biosynthesis";"Molybdenum cofactor biosynthesis"
Medex_00030842-RA	7	Reactome: R-HSA-141444;Reactome: R-HSA-68877;Reactome: R-HSA-2500257;Reactome: R-HSA-6811434;Reactome: R-HSA-9648025;Reactome: R-HSA-5663220;Reactome: R-HSA-2467813	"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Mitotic Prometaphase";"Resolution of Sister Chromatid Cohesion";"COPI-dependent Golgi-to-ER retrograde traffic";"EML4 and NUDC in mitotic spindle formation";"RHO GTPases Activate Formins";"Separation of Sister Chromatids"
Medex_00081365-RA	1	Reactome: R-HSA-2132295	"MHC class II antigen presentation"
Medex_00003583-RA	3	Reactome: R-HSA-450513;Reactome: R-HSA-450385;Reactome: R-HSA-430039	"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"mRNA decay by 5' to 3' exoribonuclease"
Medex_00066910-RA	1	Reactome: R-HSA-5389840	"Mitochondrial translation elongation"
Medex_00010587-RA	6	MetaCyc: PWY-6733;MetaCyc: PWY-7782;MetaCyc: PWY-7656;KEGG: 00073+1.2.1.84;MetaCyc: PWY-5884;Reactome: R-HSA-9640463	"Sporopollenin precursors biosynthesis";"Plasmalogen biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax esters biosynthesis I";"Wax biosynthesis"
Medex_00051526-RA	1	Reactome: R-HSA-8943724	"Regulation of PTEN gene transcription"
Medex_00009152-RA	57	Reactome: R-HSA-349425;Reactome: R-HSA-1236978;Reactome: R-HSA-180534;Reactome: R-HSA-5632684;Reactome: R-HSA-174178;Reactome: R-HSA-5607761;Reactome: R-HSA-5610780;Reactome: R-HSA-8852276;Reactome: R-HSA-195253;Reactome: R-HSA-8939902;Reactome: R-HSA-75815;Reactome: R-HSA-5687128;Reactome: R-HSA-5668541;Reactome: R-HSA-5689603;Reactome: R-HSA-4608870;Reactome: R-HSA-5610785;Reactome: R-HSA-5689880;Reactome: R-HSA-180585;Reactome: R-HSA-450408;Reactome: R-HSA-4641258;Reactome: R-HSA-2467813;Reactome: R-HSA-9010553;Reactome: R-HSA-382556;Reactome: R-HSA-68949;Reactome: R-HSA-211733;Reactome: R-HSA-8939236;Reactome: R-HSA-983168;Reactome: R-HSA-202424;Reactome: R-HSA-5658442;Reactome: R-HSA-8941858;Reactome: R-HSA-5358346;Reactome: R-HSA-6798695;Reactome: R-HSA-9020702;Reactome: R-HSA-174184;Reactome: R-HSA-5607764;Reactome: R-HSA-1169091;Reactome: R-HSA-174154;Reactome: R-HSA-8951664;Reactome: R-HSA-2871837;Reactome: R-HSA-174113;Reactome: R-HSA-4641257;Reactome: R-HSA-350562;Reactome: R-HSA-5678895;Reactome: R-HSA-69481;Reactome: R-HSA-8948751;Reactome: R-HSA-9604323;Reactome: R-HSA-68827;Reactome: R-HSA-69017;Reactome: R-HSA-1234176;Reactome: R-HSA-5362768;Reactome: R-HSA-69601;Reactome: R-HSA-5676590;Reactome: R-HSA-1236974;Reactome: R-HSA-8854050;Reactome: R-HSA-5610783;Reactome: R-HSA-187577;Reactome: R-HSA-174084	"Autodegradation of the E3 ubiquitin ligase COP1";"Cross-presentation of soluble exogenous antigens (endosomes)";"Vpu mediated degradation of CD4";"Hedgehog 'on' state";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Dectin-1 mediated noncanonical NF-kB signaling";"Degradation of GLI1 by the proteasome";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Degradation of beta-catenin by the destruction complex";"Regulation of RUNX2 expression and activity";"Ubiquitin-dependent degradation of Cyclin D";"MAPK6/MAPK4 signaling";"TNFR2 non-canonical NF-kB pathway";"UCH proteinases";"Asymmetric localization of PCP proteins";"GLI3 is processed to GLI3R by the proteasome";"Ub-specific processing proteases";"Vif-mediated degradation of APOBEC3G";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Degradation of DVL";"Separation of Sister Chromatids";"Regulation of expression of SLITs and ROBOs";"ABC-family proteins mediated transport";"Orc1 removal from chromatin";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Antigen processing: Ubiquitination & Proteasome degradation";"Downstream TCR signaling";"Regulation of RAS by GAPs";"Regulation of RUNX3 expression and activity";"Hedgehog ligand biogenesis";"Neutrophil degranulation";"Interleukin-1 signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"CLEC7A (Dectin-1) signaling";"Activation of NF-kappaB in B cells";"APC/C:Cdc20 mediated degradation of Securin";"Neddylation";"FCERI mediated NF-kB activation";"SCF-beta-TrCP mediated degradation of Emi1";"Degradation of AXIN";"Regulation of ornithine decarboxylase (ODC)";"Defective CFTR causes cystic fibrosis";"G2/M Checkpoints";"Regulation of PTEN stability and activity";"Negative regulation of NOTCH4 signaling";"CDT1 association with the CDC6:ORC:origin complex";"CDK-mediated phosphorylation and removal of Cdc6";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"NIK-->noncanonical NF-kB signaling";"ER-Phagosome pathway";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Degradation of GLI2 by the proteasome";"SCF(Skp2)-mediated degradation of p27/p21";"Autodegradation of Cdh1 by Cdh1:APC/C"
Medex_00040515-RA	26	Reactome: R-HSA-8941856;Reactome: R-HSA-3134973;Reactome: R-HSA-9617629;Reactome: R-HSA-2644606;Reactome: R-HSA-3214847;Reactome: R-HSA-201722;Reactome: R-HSA-9013508;Reactome: R-HSA-400253;Reactome: R-HSA-1989781;Reactome: R-HSA-1912408;Reactome: R-HSA-210744;Reactome: R-HSA-1234158;Reactome: R-HSA-8866907;Reactome: R-HSA-9614657;Reactome: R-HSA-9013695;Reactome: R-HSA-381340;Reactome: R-HSA-2122947;Reactome: R-HSA-3899300;Reactome: R-HSA-2894862;Reactome: R-HSA-933541;Reactome: R-HSA-5621575;Reactome: R-HSA-5617472;Reactome: R-HSA-918233;Reactome: R-HSA-3371568;Reactome: R-HSA-9018519;Reactome: R-HSA-1368082	"RUNX3 regulates NOTCH signaling";"LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production";"Regulation of FOXO transcriptional activity by acetylation";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"HATs acetylate histones";"Formation of the beta-catenin:TCF transactivating complex";"NOTCH3 Intracellular Domain Regulates Transcription";"Circadian Clock";"PPARA activates gene expression";"Pre-NOTCH Transcription and Translation";"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"Regulation of gene expression by Hypoxia-inducible Factor";"Activation of the TFAP2 (AP-2) family of transcription factors";"FOXO-mediated transcription of cell death genes";"NOTCH4 Intracellular Domain Regulates Transcription";"Transcriptional regulation of white adipocyte differentiation";"NOTCH1 Intracellular Domain Regulates Transcription";"SUMOylation of transcription cofactors";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"TRAF6 mediated IRF7 activation";"CD209 (DC-SIGN) signaling";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"TRAF3-dependent IRF activation pathway";"Attenuation phase";"Estrogen-dependent gene expression";"RORA activates gene expression"
Medex_00004919-RA	18	Reactome: R-HSA-113418;Reactome: R-HSA-6807505;Reactome: R-HSA-167158;Reactome: R-HSA-77075;Reactome: R-HSA-72086;Reactome: R-HSA-112382;Reactome: R-HSA-167238;Reactome: R-HSA-6796648;Reactome: R-HSA-167287;Reactome: R-HSA-167243;Reactome: R-HSA-167152;Reactome: R-HSA-674695;Reactome: R-HSA-167242;Reactome: R-HSA-167290;Reactome: R-HSA-167200;Reactome: R-HSA-167246;Reactome: R-HSA-167160;Reactome: R-HSA-75955	"Formation of the Early Elongation Complex";"RNA polymerase II transcribes snRNA genes";"Formation of the HIV-1 Early Elongation Complex";"RNA Pol II CTD phosphorylation and interaction with CE";"mRNA Capping";"Formation of RNA Pol II elongation complex";"Pausing and recovery of Tat-mediated HIV elongation";"TP53 Regulates Transcription of DNA Repair Genes";"HIV elongation arrest and recovery";"Tat-mediated HIV elongation arrest and recovery";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Polymerase II Pre-transcription Events";"Abortive elongation of HIV-1 transcript in the absence of Tat";"Pausing and recovery of HIV elongation";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Tat-mediated elongation of the HIV-1 transcript";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"RNA Polymerase II Transcription Elongation"
Medex_00035621-RA	11	Reactome: R-HSA-5685942;Reactome: R-HSA-5696397;Reactome: R-HSA-6782210;Reactome: R-HSA-174430;Reactome: R-HSA-5651801;Reactome: R-HSA-5656169;Reactome: R-HSA-68952;Reactome: R-HSA-68962;Reactome: R-HSA-5696400;Reactome: R-HSA-110314;Reactome: R-HSA-6782135	"HDR through Homologous Recombination (HRR)";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Telomere C-strand synthesis initiation";"PCNA-Dependent Long Patch Base Excision Repair";"Termination of translesion DNA synthesis";"DNA replication initiation";"Activation of the pre-replicative complex";"Dual Incision in GG-NER";"Recognition of DNA damage by PCNA-containing replication complex";"Dual incision in TC-NER"
Medex_00059936-RA	1	Reactome: R-HSA-428890	"Role of ABL in ROBO-SLIT signaling"
Medex_00074759-RA	2	Reactome: R-HSA-1482798;Reactome: R-HSA-1268020	"Acyl chain remodeling of CL";"Mitochondrial protein import"
Medex_00058290-RA	5	Reactome: R-HSA-68962;Reactome: R-HSA-176974;Reactome: R-HSA-176187;Reactome: R-HSA-68949;Reactome: R-HSA-68867	"Activation of the pre-replicative complex";"Unwinding of DNA";"Activation of ATR in response to replication stress";"Orc1 removal from chromatin";"Assembly of the pre-replicative complex"
Medex_00038119-RA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
Medex_00055530-RA	2	Reactome: R-HSA-5689603;Reactome: R-HSA-5696394	"UCH proteinases";"DNA Damage Recognition in GG-NER"
Medex_00045010-RA	4	Reactome: R-HSA-2408522;Reactome: R-HSA-379716;Reactome: R-HSA-379726;KEGG: 00970+6.1.1.18	"Selenoamino acid metabolism";"Cytosolic tRNA aminoacylation";"Mitochondrial tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis"
Medex_00017133-RA	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
Medex_00028012-RA	4	Reactome: R-HSA-8856828;Reactome: R-HSA-2029482;Reactome: R-HSA-3928662;Reactome: R-HSA-5663213	"Clathrin-mediated endocytosis";"Regulation of actin dynamics for phagocytic cup formation";"EPHB-mediated forward signaling";"RHO GTPases Activate WASPs and WAVEs"
Medex_00002531-RA	8	Reactome: R-HSA-380972;Reactome: R-HSA-3371571;Reactome: R-HSA-1632852;Reactome: R-HSA-165159;Reactome: R-HSA-9639288;Reactome: R-HSA-166208;Reactome: R-HSA-5628897;Reactome: R-HSA-8943724	"Energy dependent regulation of mTOR by LKB1-AMPK";"HSF1-dependent transactivation";"Macroautophagy";"mTOR signalling";"Amino acids regulate mTORC1";"mTORC1-mediated signalling";"TP53 Regulates Metabolic Genes";"Regulation of PTEN gene transcription"
Medex_00004187-RA	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
Medex_00007750-RA	16	Reactome: R-HSA-200425;MetaCyc: PWY-5966-1;MetaCyc: PWY-6722;Reactome: R-HSA-163765;MetaCyc: PWY-5789;KEGG: 00720+6.4.1.2;Reactome: R-HSA-196780;MetaCyc: PWY-4381;MetaCyc: PWY-5743;Reactome: R-HSA-2426168;KEGG: 00061+6.4.1.2;KEGG: 00640+6.4.1.2;KEGG: 00620+6.4.1.2;MetaCyc: PWY-6679;KEGG: 00254+6.4.1.2;MetaCyc: PWY-5744	"Carnitine metabolism";"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)";"Candicidin biosynthesis";"ChREBP activates metabolic gene expression";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Carbon fixation pathways in prokaryotes";"Biotin transport and metabolism";"Fatty acid biosynthesis initiation (bacteria and plants)";"3-hydroxypropanoate cycle";"Activation of gene expression by SREBF (SREBP)";"Fatty acid biosynthesis";"Propanoate metabolism";"Pyruvate metabolism";"Jadomycin biosynthesis";"Aflatoxin biosynthesis";"Glyoxylate assimilation"
Medex_00022819-RA	1	Reactome: R-HSA-1237044	"Erythrocytes take up carbon dioxide and release oxygen"
Medex_00009931-RA	5	MetaCyc: PWY-7282;MetaCyc: PWY-7204;Reactome: R-HSA-6798695;Reactome: R-HSA-964975;KEGG: 00750+2.7.1.35	"4-amino-2-methyl-5-phosphomethylpyrimidine biosynthesis";"Pyridoxal 5'-phosphate salvage II (plants)";"Neutrophil degranulation";"Vitamins B6 activation to pyridoxal phosphate";"Vitamin B6 metabolism"
Medex_00040080-RA	14	MetaCyc: PWY-7035;Reactome: R-HSA-75876;MetaCyc: PWY-5972;MetaCyc: PWY-7602;MetaCyc: PWY-7619;MetaCyc: PWY-7036;MetaCyc: PWY-6433;MetaCyc: PWY-8041;MetaCyc: PWY-5080;MetaCyc: PWY-7725;MetaCyc: PWY-6598;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7601;MetaCyc: PWY-7724	"(9Z)-tricosene biosynthesis";"Synthesis of very long-chain fatty acyl-CoAs";"Stearate biosynthesis I (animals)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Juniperonate biosynthesis";"Very long chain fatty acid biosynthesis II";"Hydroxylated fatty acid biosynthesis (plants)";"Ultra-long-chain fatty acid biosynthesis";"Very long chain fatty acid biosynthesis I";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Sciadonate biosynthesis";"Fatty acid elongation";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)"
Medex_00042569-RA	1	Reactome: R-HSA-211945	"Phase I - Functionalization of compounds"
Medex_00091211-RA	1	Reactome: R-HSA-525793	"Myogenesis"
Medex_00007024-RA	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00056763-RA	1	Reactome: R-HSA-3000178	"ECM proteoglycans"
Medex_00062621-RA	1	KEGG: 00970+6.1.1.16	"Aminoacyl-tRNA biosynthesis"
Medex_00034662-RA	3	Reactome: R-HSA-5663213;Reactome: R-HSA-2029482;Reactome: R-HSA-4420097	"RHO GTPases Activate WASPs and WAVEs";"Regulation of actin dynamics for phagocytic cup formation";"VEGFA-VEGFR2 Pathway"
Medex_00000004-RA	24	Reactome: R-HSA-1445148;Reactome: R-HSA-5663220;Reactome: R-HSA-3371497;Reactome: R-HSA-2500257;Reactome: R-HSA-380320;Reactome: R-HSA-9646399;Reactome: R-HSA-5617833;Reactome: R-HSA-2467813;Reactome: R-HSA-68877;Reactome: R-HSA-9648025;Reactome: R-HSA-6811434;Reactome: R-HSA-9609690;Reactome: R-HSA-6811436;Reactome: R-HSA-8955332;Reactome: R-HSA-437239;Reactome: R-HSA-6807878;Reactome: R-HSA-190861;Reactome: R-HSA-9619483;Reactome: R-HSA-190840;Reactome: R-HSA-2132295;Reactome: R-HSA-5626467;Reactome: R-HSA-9609736;Reactome: R-HSA-983189;Reactome: R-HSA-8852276	"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"RHO GTPases Activate Formins";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Resolution of Sister Chromatid Cohesion";"Recruitment of NuMA to mitotic centrosomes";"Aggrephagy";"Cilium Assembly";"Separation of Sister Chromatids";"Mitotic Prometaphase";"EML4 and NUDC in mitotic spindle formation";"COPI-dependent Golgi-to-ER retrograde traffic";"HCMV Early Events";"COPI-independent Golgi-to-ER retrograde traffic";"Carboxyterminal post-translational modifications of tubulin";"Recycling pathway of L1";"COPI-mediated anterograde transport";"Gap junction assembly";"Activation of AMPK downstream of NMDARs";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"MHC class II antigen presentation";"RHO GTPases activate IQGAPs";"Assembly and cell surface presentation of NMDA receptors";"Kinesins";"The role of GTSE1 in G2/M progression after G2 checkpoint"
Medex_00088979-RA	3	Reactome: R-HSA-159236;Reactome: R-HSA-72187;Reactome: R-HSA-73856	"Transport of Mature mRNA derived from an Intron-Containing Transcript";"mRNA 3'-end processing";"RNA Polymerase II Transcription Termination"
Medex_00031462-RA	1	Reactome: R-HSA-203927	"MicroRNA (miRNA) biogenesis"
Medex_00002004-RA	2	Reactome: R-HSA-983168;Reactome: R-HSA-8951664	"Antigen processing: Ubiquitination & Proteasome degradation";"Neddylation"
Medex_00075707-RA	10	MetaCyc: PWY-5278;Reactome: R-HSA-174362;MetaCyc: PWY-5340;MetaCyc: PWY-6683;KEGG: 00450+2.7.7.4;KEGG: 00261+2.7.7.4;KEGG: 00230+2.7.7.4;MetaCyc: PWY-6932;Reactome: R-HSA-2408550;KEGG: 00920+2.7.7.4	"Sulfite oxidation III";"Transport and synthesis of PAPS";"Sulfate activation for sulfonation";"Assimilatory sulfate reduction III";"Selenocompound metabolism";"Monobactam biosynthesis";"Purine metabolism";"Selenate reduction";"Metabolism of ingested H2SeO4 and H2SeO3 into H2Se";"Sulfur metabolism"
Medex_00030625-RA	5	Reactome: R-HSA-199220;Reactome: R-HSA-9029558;Reactome: R-HSA-75105;Reactome: R-HSA-2426168;Reactome: R-HSA-163765	"Vitamin B5 (pantothenate) metabolism";"NR1H2 & NR1H3 regulate gene expression linked to lipogenesis";"Fatty acyl-CoA biosynthesis";"Activation of gene expression by SREBF (SREBP)";"ChREBP activates metabolic gene expression"
Medex_00040463-RA	6	KEGG: 00514+2.4.1.122;KEGG: 00512+2.4.1.122;MetaCyc: PWY-7433;Reactome: R-HSA-913709;MetaCyc: PWY-7290;Reactome: R-HSA-5083632	"Other types of O-glycan biosynthesis";"Mucin type O-glycan biosynthesis";"Mucin core 1 and core 2 O-glycosylation";"O-linked glycosylation of mucins";"Escherichia coli serotype O86 O-antigen biosynthesis";"Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)"
Medex_00035192-RA	4	Reactome: R-HSA-112382;Reactome: R-HSA-8866654;Reactome: R-HSA-75955;Reactome: R-HSA-674695	"Formation of RNA Pol II elongation complex";"E3 ubiquitin ligases ubiquitinate target proteins";"RNA Polymerase II Transcription Elongation";"RNA Polymerase II Pre-transcription Events"
Medex_00067677-RA	1	Reactome: R-HSA-8949664	"Processing of SMDT1"
Medex_00027566-RA	1	Reactome: R-HSA-1632852	"Macroautophagy"
Medex_00062953-RA	1	Reactome: R-HSA-432047	"Passive transport by Aquaporins"
Medex_00004863-RA	5	Reactome: R-HSA-72163;Reactome: R-HSA-77595;Reactome: R-HSA-73856;Reactome: R-HSA-72187;Reactome: R-HSA-159231	"mRNA Splicing - Major Pathway";"Processing of Intronless Pre-mRNAs";"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing";"Transport of Mature mRNA Derived from an Intronless Transcript"
Medex_00059755-RA	1	Reactome: R-HSA-4551638	"SUMOylation of chromatin organization proteins"
Medex_00013827-RA	3	KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway"
Medex_00044134-RA	56	Reactome: R-HSA-5358346;Reactome: R-HSA-8941858;Reactome: R-HSA-5658442;Reactome: R-HSA-202424;Reactome: R-HSA-983168;Reactome: R-HSA-9020702;Reactome: R-HSA-2467813;Reactome: R-HSA-4641258;Reactome: R-HSA-450408;Reactome: R-HSA-180585;Reactome: R-HSA-68949;Reactome: R-HSA-382556;Reactome: R-HSA-8939236;Reactome: R-HSA-211733;Reactome: R-HSA-9010553;Reactome: R-HSA-75815;Reactome: R-HSA-8939902;Reactome: R-HSA-195253;Reactome: R-HSA-5689880;Reactome: R-HSA-5610785;Reactome: R-HSA-4608870;Reactome: R-HSA-5689603;Reactome: R-HSA-5668541;Reactome: R-HSA-5687128;Reactome: R-HSA-5632684;Reactome: R-HSA-180534;Reactome: R-HSA-1236978;Reactome: R-HSA-349425;Reactome: R-HSA-8852276;Reactome: R-HSA-5610780;Reactome: R-HSA-5607761;Reactome: R-HSA-174178;Reactome: R-HSA-174084;Reactome: R-HSA-187577;Reactome: R-HSA-5610783;Reactome: R-HSA-8854050;Reactome: R-HSA-1236974;Reactome: R-HSA-69481;Reactome: R-HSA-5678895;Reactome: R-HSA-350562;Reactome: R-HSA-4641257;Reactome: R-HSA-174113;Reactome: R-HSA-5676590;Reactome: R-HSA-5362768;Reactome: R-HSA-1234176;Reactome: R-HSA-69017;Reactome: R-HSA-69601;Reactome: R-HSA-8948751;Reactome: R-HSA-9604323;Reactome: R-HSA-68827;Reactome: R-HSA-174154;Reactome: R-HSA-1169091;Reactome: R-HSA-5607764;Reactome: R-HSA-174184;Reactome: R-HSA-2871837;Reactome: R-HSA-8951664	"Hedgehog ligand biogenesis";"Regulation of RUNX3 expression and activity";"Regulation of RAS by GAPs";"Downstream TCR signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Interleukin-1 signaling";"Separation of Sister Chromatids";"Degradation of DVL";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Vif-mediated degradation of APOBEC3G";"Orc1 removal from chromatin";"ABC-family proteins mediated transport";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Regulation of expression of SLITs and ROBOs";"Ubiquitin-dependent degradation of Cyclin D";"Regulation of RUNX2 expression and activity";"Degradation of beta-catenin by the destruction complex";"Ub-specific processing proteases";"GLI3 is processed to GLI3R by the proteasome";"Asymmetric localization of PCP proteins";"UCH proteinases";"TNFR2 non-canonical NF-kB pathway";"MAPK6/MAPK4 signaling";"Hedgehog 'on' state";"Vpu mediated degradation of CD4";"Cross-presentation of soluble exogenous antigens (endosomes)";"Autodegradation of the E3 ubiquitin ligase COP1";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Degradation of GLI1 by the proteasome";"Dectin-1 mediated noncanonical NF-kB signaling";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Autodegradation of Cdh1 by Cdh1:APC/C";"SCF(Skp2)-mediated degradation of p27/p21";"Degradation of GLI2 by the proteasome";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"ER-Phagosome pathway";"G2/M Checkpoints";"Defective CFTR causes cystic fibrosis";"Regulation of ornithine decarboxylase (ODC)";"Degradation of AXIN";"SCF-beta-TrCP mediated degradation of Emi1";"NIK-->noncanonical NF-kB signaling";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"CDK-mediated phosphorylation and removal of Cdc6";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Regulation of PTEN stability and activity";"Negative regulation of NOTCH4 signaling";"CDT1 association with the CDC6:ORC:origin complex";"APC/C:Cdc20 mediated degradation of Securin";"Activation of NF-kappaB in B cells";"CLEC7A (Dectin-1) signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"FCERI mediated NF-kB activation";"Neddylation"
Medex_00006261-RA	3	Reactome: R-HSA-3371599;Reactome: R-HSA-70263;Reactome: R-HSA-196780	"Defective HLCS causes multiple carboxylase deficiency";"Gluconeogenesis";"Biotin transport and metabolism"
Medex_00002579-RA	2	Reactome: R-HSA-6783984;KEGG: 00260+1.4.4.2	"Glycine degradation";"Glycine, serine and threonine metabolism"
Medex_00072317-RA	1	Reactome: R-HSA-6798163	"Choline catabolism"
Medex_00075938-RA	3	Reactome: R-HSA-416476;Reactome: R-HSA-390696;Reactome: R-HSA-416482	"G alpha (q) signalling events";"Adrenoceptors";"G alpha (12/13) signalling events"
Medex_00102782-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00047381-RA	12	KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;Reactome: R-HSA-416482;KEGG: 04714+2.7.11.1;Reactome: R-HSA-418885;Reactome: R-HSA-416476;Reactome: R-HSA-193648;KEGG: 04151+2.7.11.1;Reactome: R-HSA-194840;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1	"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"mTOR signaling pathway";"G alpha (12/13) signalling events";"Thermogenesis";"DCC mediated attractive signaling";"G alpha (q) signalling events";"NRAGE signals death through JNK";"PI3K-Akt signaling pathway";"Rho GTPase cycle";"Relaxin signaling pathway";"Human cytomegalovirus infection"
Medex_00024602-RA	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
Medex_00025825-RA	1	Reactome: R-HSA-3295583	"TRP channels"
Medex_00010396-RA	3	Reactome: R-HSA-196807;Reactome: R-HSA-73621;Reactome: R-HSA-74259	"Nicotinate metabolism";"Pyrimidine catabolism";"Purine catabolism"
Medex_00059085-RA	2	Reactome: R-HSA-8949215;Reactome: R-HSA-983231	"Mitochondrial calcium ion transport";"Factors involved in megakaryocyte development and platelet production"
Medex_00047463-RA	3	Reactome: R-HSA-8876198;Reactome: R-HSA-6811440;Reactome: R-HSA-6811438	"RAB GEFs exchange GTP for GDP on RABs";"Retrograde transport at the Trans-Golgi-Network";"Intra-Golgi traffic"
Medex_00031527-RA	3	Reactome: R-HSA-112382;Reactome: R-HSA-75955;Reactome: R-HSA-674695	"Formation of RNA Pol II elongation complex";"RNA Polymerase II Transcription Elongation";"RNA Polymerase II Pre-transcription Events"
Medex_00003772-RA	1	Reactome: R-HSA-112126	"ALKBH3 mediated reversal of alkylation damage"
Medex_00013317-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Medex_00048220-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Medex_00044383-RA	14	Reactome: R-HSA-8948700;Reactome: R-HSA-4086398;Reactome: R-HSA-9029569;Reactome: R-HSA-9022692;Reactome: R-HSA-8943723;Reactome: R-HSA-8986944;Reactome: R-HSA-5687128;Reactome: R-HSA-8934593;Reactome: R-HSA-1912408;Reactome: R-HSA-9018519;Reactome: R-HSA-426486;Reactome: R-HSA-5628897;Reactome: R-HSA-203927;Reactome: R-HSA-426496	"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"Ca2+ pathway";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Regulation of MECP2 expression and activity";"Regulation of PTEN mRNA translation";"Transcriptional Regulation by MECP2";"MAPK6/MAPK4 signaling";"Regulation of RUNX1 Expression and Activity";"Pre-NOTCH Transcription and Translation";"Estrogen-dependent gene expression";"Small interfering RNA (siRNA) biogenesis";"TP53 Regulates Metabolic Genes";"MicroRNA (miRNA) biogenesis";"Post-transcriptional silencing by small RNAs"
Medex_00085635-RA	3	Reactome: R-HSA-6811434;Reactome: R-HSA-6798695;Reactome: R-HSA-6807878	"COPI-dependent Golgi-to-ER retrograde traffic";"Neutrophil degranulation";"COPI-mediated anterograde transport"
Medex_00041371-RA	1	Reactome: R-HSA-380320	"Recruitment of NuMA to mitotic centrosomes"
Medex_00082947-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Medex_00025770-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00054545-RA	2	Reactome: R-HSA-6783310;Reactome: R-HSA-5693568	"Fanconi Anemia Pathway";"Resolution of D-loop Structures through Holliday Junction Intermediates"
Medex_00032823-RA	5	Reactome: R-HSA-69205;Reactome: R-HSA-68962;Reactome: R-HSA-68949;Reactome: R-HSA-68867;Reactome: R-HSA-68827	"G1/S-Specific Transcription";"Activation of the pre-replicative complex";"Orc1 removal from chromatin";"Assembly of the pre-replicative complex";"CDT1 association with the CDC6:ORC:origin complex"
Medex_00103490-RA	5	MetaCyc: PWY-4361;Reactome: R-HSA-9627069;KEGG: 00270+4.2.1.109;Reactome: R-HSA-111458;Reactome: R-HSA-1237112	"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I";"Regulation of the apoptosome activity";"Cysteine and methionine metabolism";"Formation of apoptosome";"Methionine salvage pathway"
Medex_00014259-RA	6	Reactome: R-HSA-77588;Reactome: R-HSA-191859;Reactome: R-HSA-72165;Reactome: R-HSA-73856;Reactome: R-HSA-111367;Reactome: R-HSA-72163	"SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs";"snRNP Assembly";"mRNA Splicing - Minor Pathway";"RNA Polymerase II Transcription Termination";"SLBP independent Processing of Histone Pre-mRNAs";"mRNA Splicing - Major Pathway"
Medex_00067356-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Medex_00044349-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00041540-RA	5	Reactome: R-HSA-163765;Reactome: R-HSA-2426168;Reactome: R-HSA-199220;Reactome: R-HSA-75105;Reactome: R-HSA-9029558	"ChREBP activates metabolic gene expression";"Activation of gene expression by SREBF (SREBP)";"Vitamin B5 (pantothenate) metabolism";"Fatty acyl-CoA biosynthesis";"NR1H2 & NR1H3 regulate gene expression linked to lipogenesis"
Medex_00068500-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Medex_00085552-RA	2	Reactome: R-HSA-196783;KEGG: 00770+6.3.2.5	"Coenzyme A biosynthesis";"Pantothenate and CoA biosynthesis"
Medex_00012442-RA	1	Reactome: R-HSA-1632852	"Macroautophagy"
Medex_00023213-RA	6	Reactome: R-HSA-8957275;Reactome: R-HSA-381426;Reactome: R-HSA-5626467;Reactome: R-HSA-2173796;Reactome: R-HSA-3769402;Reactome: R-HSA-201722	"Post-translational protein phosphorylation";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"RHO GTPases activate IQGAPs";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"Deactivation of the beta-catenin transactivating complex";"Formation of the beta-catenin:TCF transactivating complex"
Medex_00044644-RA	2	Reactome: R-HSA-390471;Reactome: R-HSA-1660662	"Association of TriC/CCT with target proteins during biosynthesis";"Glycosphingolipid metabolism"
Medex_00016147-RA	1	Reactome: R-HSA-8951664	"Neddylation"
Medex_00034320-RA	5	Reactome: R-HSA-1483166;MetaCyc: PWY-5667;MetaCyc: PWY-5981;MetaCyc: PWY-7902;KEGG: 00564+1.1.1.94	"Synthesis of PA";"CDP-diacylglycerol biosynthesis I";"CDP-diacylglycerol biosynthesis III";"Glucosylglycerol biosynthesis";"Glycerophospholipid metabolism"
Medex_00102294-RA	2	Reactome: R-HSA-5205685;Reactome: R-HSA-983231	"Pink/Parkin Mediated Mitophagy";"Factors involved in megakaryocyte development and platelet production"
Medex_00034076-RA	14	MetaCyc: PWY-3661;KEGG: 00260+2.1.2.1;MetaCyc: PWY-5497;MetaCyc: PWY-2201;MetaCyc: PWY-181;MetaCyc: PWY-3661-1;KEGG: 00630+2.1.2.1;Reactome: R-HSA-196757;KEGG: 00460+2.1.2.1;KEGG: 00680+2.1.2.1;MetaCyc: PWY-1622;MetaCyc: PWY-3841;KEGG: 00670+2.1.2.1;MetaCyc: PWY-2161	"Glycine betaine degradation I";"Glycine, serine and threonine metabolism";"Purine nucleobases degradation II (anaerobic)";"Folate transformations I";"Photorespiration ";"Glycine betaine degradation II (mammalian)";"Glyoxylate and dicarboxylate metabolism";"Metabolism of folate and pterines";"Cyanoamino acid metabolism";"Methane metabolism";"Formaldehyde assimilation I (serine pathway)";"Folate transformations II (plants)";"One carbon pool by folate";"Folate polyglutamylation"
Medex_00066306-RA	4	KEGG: 00640+1.2.1.27;Reactome: R-HSA-70895;KEGG: 00280+1.2.1.27;MetaCyc: PWY-5642	"Propanoate metabolism";"Branched-chain amino acid catabolism";"Valine, leucine and isoleucine degradation";"2,4-dinitrotoluene degradation"
Medex_00056474-RA	10	Reactome: R-HSA-400206;Reactome: R-HSA-9022538;Reactome: R-HSA-427413;Reactome: R-HSA-3899300;Reactome: R-HSA-8936459;Reactome: R-HSA-9615017;Reactome: R-HSA-9022702;Reactome: R-HSA-983231;Reactome: R-HSA-9022699;Reactome: R-HSA-9022692	"Regulation of lipid metabolism by PPARalpha";"Loss of MECP2 binding ability to 5mC-DNA";"NoRC negatively regulates rRNA expression";"SUMOylation of transcription cofactors";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"MECP2 regulates transcription of neuronal ligands";"Factors involved in megakaryocyte development and platelet production";"MECP2 regulates neuronal receptors and channels";"Regulation of MECP2 expression and activity"
Medex_00084736-RA	1	Reactome: R-HSA-6798163	"Choline catabolism"
Medex_00090097-RA	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
Medex_00089948-RA	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
Medex_00066254-RA	13	Reactome: R-HSA-380972;Reactome: R-HSA-3371571;Reactome: R-HSA-1257604;Reactome: R-HSA-165159;Reactome: R-HSA-9639288;Reactome: R-HSA-1632852;Reactome: R-HSA-166208;Reactome: R-HSA-6804757;Reactome: R-HSA-5218920;Reactome: R-HSA-389357;Reactome: R-HSA-5674400;Reactome: R-HSA-5628897;Reactome: R-HSA-8943724	"Energy dependent regulation of mTOR by LKB1-AMPK";"HSF1-dependent transactivation";"PIP3 activates AKT signaling";"mTOR signalling";"Amino acids regulate mTORC1";"Macroautophagy";"mTORC1-mediated signalling";"Regulation of TP53 Degradation";"VEGFR2 mediated vascular permeability";"CD28 dependent PI3K/Akt signaling";"Constitutive Signaling by AKT1 E17K in Cancer";"TP53 Regulates Metabolic Genes";"Regulation of PTEN gene transcription"
Medex_00021953-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00033650-RA	1	Reactome: R-HSA-74217	"Purine salvage"
Medex_00089651-RA	52	Reactome: R-HSA-167200;Reactome: R-HSA-167246;Reactome: R-HSA-167160;Reactome: R-HSA-5578749;Reactome: R-HSA-5601884;Reactome: R-HSA-5617472;Reactome: R-HSA-203927;Reactome: R-HSA-6782135;Reactome: R-HSA-9018519;Reactome: R-HSA-75955;Reactome: R-HSA-5250924;Reactome: R-HSA-76066;Reactome: R-HSA-749476;Reactome: R-HSA-167242;Reactome: R-HSA-167290;Reactome: R-HSA-6781823;Reactome: R-HSA-167172;Reactome: R-HSA-72163;Reactome: R-HSA-8851708;Reactome: R-HSA-73779;Reactome: R-HSA-112382;Reactome: R-HSA-76071;Reactome: R-HSA-73980;Reactome: R-HSA-113418;Reactome: R-HSA-6807505;Reactome: R-HSA-1834949;Reactome: R-HSA-75953;Reactome: R-HSA-167161;Reactome: R-HSA-73780;Reactome: R-HSA-72165;Reactome: R-HSA-76061;Reactome: R-HSA-76042;Reactome: R-HSA-167162;Reactome: R-HSA-167287;Reactome: R-HSA-167243;Reactome: R-HSA-73863;Reactome: R-HSA-73776;Reactome: R-HSA-674695;Reactome: R-HSA-167152;Reactome: R-HSA-6782210;Reactome: R-HSA-73772;Reactome: R-HSA-77075;Reactome: R-HSA-168325;Reactome: R-HSA-427413;Reactome: R-HSA-72203;Reactome: R-HSA-72086;Reactome: R-HSA-6796648;Reactome: R-HSA-167238;Reactome: R-HSA-6803529;Reactome: R-HSA-73762;Reactome: R-HSA-167158;Reactome: R-HSA-6781827	"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Tat-mediated elongation of the HIV-1 transcript";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Transcriptional regulation by small RNAs";"PIWI-interacting RNA (piRNA) biogenesis";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"MicroRNA (miRNA) biogenesis";"Dual incision in TC-NER";"Estrogen-dependent gene expression";"RNA Polymerase II Transcription Elongation";"B-WICH complex positively regulates rRNA expression";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Abortive And Retractive Initiation";"Abortive elongation of HIV-1 transcript in the absence of Tat";"Pausing and recovery of HIV elongation";"Formation of TC-NER Pre-Incision Complex";"Transcription of the HIV genome";"mRNA Splicing - Major Pathway";"Signaling by FGFR2 IIIa TM";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Formation of RNA Pol II elongation complex";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Transcription Termination";"Formation of the Early Elongation Complex";"RNA polymerase II transcribes snRNA genes";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase II Transcription Initiation";"HIV Transcription Initiation";"RNA Polymerase III Chain Elongation";"mRNA Splicing - Minor Pathway";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II HIV Promoter Escape";"HIV elongation arrest and recovery";"Tat-mediated HIV elongation arrest and recovery";"RNA Polymerase I Transcription Termination";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Pre-transcription Events";"Formation of HIV elongation complex in the absence of HIV Tat";"Gap-filling DNA repair synthesis and ligation in TC-NER";"RNA Polymerase I Promoter Escape";"RNA Pol II CTD phosphorylation and interaction with CE";"Viral Messenger RNA Synthesis";"NoRC negatively regulates rRNA expression";"Processing of Capped Intron-Containing Pre-mRNA";"mRNA Capping";"TP53 Regulates Transcription of DNA Repair Genes";"Pausing and recovery of Tat-mediated HIV elongation";"FGFR2 alternative splicing";"RNA Polymerase I Transcription Initiation";"Formation of the HIV-1 Early Elongation Complex";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)"
Medex_00060545-RA	2	Reactome: R-HSA-6790901;Reactome: R-HSA-171319	"rRNA modification in the nucleus and cytosol";"Telomere Extension By Telomerase"
Medex_00014226-RA	3	Reactome: R-HSA-73856;Reactome: R-HSA-72187;Reactome: R-HSA-159236	"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing";"Transport of Mature mRNA derived from an Intron-Containing Transcript"
Medex_00001479-RA	1	Reactome: R-HSA-70895	"Branched-chain amino acid catabolism"
Medex_00015502-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00064521-RA	1	Reactome: R-HSA-8963693	"Aspartate and asparagine metabolism"
Medex_00022977-RA	1	Reactome: R-HSA-209968	"Thyroxine biosynthesis"
Medex_00024848-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Medex_00074366-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Medex_00087586-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Medex_00067868-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Medex_00020336-RA	10	MetaCyc: PWY-5030;KEGG: 00720+1.5.1.5+3.5.4.9;MetaCyc: PWY-1722;MetaCyc: PWY-3841;MetaCyc: PWY-6613;MetaCyc: PWY-7909;KEGG: 00670+1.5.1.5+3.5.4.9;MetaCyc: PWY-2201;MetaCyc: PWY-5497;Reactome: R-HSA-196757	"L-histidine degradation III";"Carbon fixation pathways in prokaryotes";"Formate assimilation into 5,10-methylenetetrahydrofolate";"Folate transformations II (plants)";"Tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate";"Formaldehyde oxidation VII (THF pathway)";"One carbon pool by folate";"Folate transformations I";"Purine nucleobases degradation II (anaerobic)";"Metabolism of folate and pterines"
Medex_00056030-RA	3	KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16	"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
Medex_00042510-RA	1	Reactome: R-HSA-156842	"Eukaryotic Translation Elongation"
Medex_00011185-RA	6	Reactome: R-HSA-72689;Reactome: R-HSA-72706;Reactome: R-HSA-156827;Reactome: R-HSA-72695;Reactome: R-HSA-72702;Reactome: R-HSA-72649	"Formation of a pool of free 40S subunits";"GTP hydrolysis and joining of the 60S ribosomal subunit";"L13a-mediated translational silencing of Ceruloplasmin expression";"Formation of the ternary complex, and subsequently, the 43S complex";"Ribosomal scanning and start codon recognition";"Translation initiation complex formation"
Medex_00057400-RA	6	KEGG: 00531+3.2.1.23;KEGG: 00052+3.2.1.23;KEGG: 00604+3.2.1.23;KEGG: 00511+3.2.1.23;KEGG: 00600+3.2.1.23;MetaCyc: PWY-6807	"Glycosaminoglycan degradation";"Galactose metabolism";"Glycosphingolipid biosynthesis - ganglio series";"Other glycan degradation";"Sphingolipid metabolism";"Xyloglucan degradation II (exoglucanase)"
Medex_00046490-RA	3	Reactome: R-HSA-6811438;Reactome: R-HSA-6807878;Reactome: R-HSA-6811440	"Intra-Golgi traffic";"COPI-mediated anterograde transport";"Retrograde transport at the Trans-Golgi-Network"
Medex_00096043-RA	1	Reactome: R-HSA-376172	"DSCAM interactions"
Medex_00092331-RA	1	Reactome: R-HSA-3214858	"RMTs methylate histone arginines"
Medex_00030614-RA	6	Reactome: R-HSA-5663220;Reactome: R-HSA-2467813;Reactome: R-HSA-2500257;Reactome: R-HSA-68877;Reactome: R-HSA-141444;Reactome: R-HSA-9648025	"RHO GTPases Activate Formins";"Separation of Sister Chromatids";"Resolution of Sister Chromatid Cohesion";"Mitotic Prometaphase";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"EML4 and NUDC in mitotic spindle formation"
Medex_00034075-RA	14	KEGG: 00460+2.1.2.1;KEGG: 00630+2.1.2.1;MetaCyc: PWY-3661-1;Reactome: R-HSA-196757;MetaCyc: PWY-181;KEGG: 00260+2.1.2.1;MetaCyc: PWY-2201;MetaCyc: PWY-5497;MetaCyc: PWY-3661;KEGG: 00670+2.1.2.1;MetaCyc: PWY-2161;MetaCyc: PWY-3841;MetaCyc: PWY-1622;KEGG: 00680+2.1.2.1	"Cyanoamino acid metabolism";"Glyoxylate and dicarboxylate metabolism";"Glycine betaine degradation II (mammalian)";"Metabolism of folate and pterines";"Photorespiration ";"Glycine, serine and threonine metabolism";"Folate transformations I";"Purine nucleobases degradation II (anaerobic)";"Glycine betaine degradation I";"One carbon pool by folate";"Folate polyglutamylation";"Folate transformations II (plants)";"Formaldehyde assimilation I (serine pathway)";"Methane metabolism"
Medex_00036020-RA	5	KEGG: 00561+3.2.1.22;MetaCyc: PWY-6527;KEGG: 00052+3.2.1.22;KEGG: 00603+3.2.1.22;KEGG: 00600+3.2.1.22	"Glycerolipid metabolism";"Stachyose degradation";"Galactose metabolism";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Sphingolipid metabolism"
Medex_00019414-RA	6	KEGG: 00531+3.2.1.23;KEGG: 00052+3.2.1.23;KEGG: 00511+3.2.1.23;KEGG: 00600+3.2.1.23;MetaCyc: PWY-6807;KEGG: 00604+3.2.1.23	"Glycosaminoglycan degradation";"Galactose metabolism";"Other glycan degradation";"Sphingolipid metabolism";"Xyloglucan degradation II (exoglucanase)";"Glycosphingolipid biosynthesis - ganglio series"
Medex_00065680-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00079315-RA	6	MetaCyc: PWY-6807;KEGG: 00511+3.2.1.23;KEGG: 00600+3.2.1.23;KEGG: 00604+3.2.1.23;KEGG: 00052+3.2.1.23;KEGG: 00531+3.2.1.23	"Xyloglucan degradation II (exoglucanase)";"Other glycan degradation";"Sphingolipid metabolism";"Glycosphingolipid biosynthesis - ganglio series";"Galactose metabolism";"Glycosaminoglycan degradation"
Medex_00028642-RA	1	Reactome: R-HSA-975578	"Reactions specific to the complex N-glycan synthesis pathway"
Medex_00068988-RA	7	Reactome: R-HSA-5685939;Reactome: R-HSA-3108214;Reactome: R-HSA-5696400;Reactome: R-HSA-5696394;Reactome: R-HSA-2173795;Reactome: R-HSA-5696395;Reactome: R-HSA-110362	"HDR through MMEJ (alt-NHEJ)";"SUMOylation of DNA damage response and repair proteins";"Dual Incision in GG-NER";"DNA Damage Recognition in GG-NER";"Downregulation of SMAD2/3:SMAD4 transcriptional activity";"Formation of Incision Complex in GG-NER";"POLB-Dependent Long Patch Base Excision Repair"
Medex_00024144-RA	1	Reactome: R-HSA-203927	"MicroRNA (miRNA) biogenesis"
Medex_00026558-RA	2	Reactome: R-HSA-390522;Reactome: R-HSA-445355	"Striated Muscle Contraction";"Smooth Muscle Contraction"
Medex_00038811-RA	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00089670-RA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
Medex_00045926-RA	7	Reactome: R-HSA-380972;Reactome: R-HSA-5628897;Reactome: R-HSA-1632852;Reactome: R-HSA-165159;Reactome: R-HSA-9639288;Reactome: R-HSA-8943724;Reactome: R-HSA-166208	"Energy dependent regulation of mTOR by LKB1-AMPK";"TP53 Regulates Metabolic Genes";"Macroautophagy";"mTOR signalling";"Amino acids regulate mTORC1";"Regulation of PTEN gene transcription";"mTORC1-mediated signalling"
Medex_00032211-RA	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
Medex_00002303-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Medex_00005266-RA	1	Reactome: R-HSA-9033241	"Peroxisomal protein import"
Medex_00080964-RA	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
Medex_00026904-RA	2	Reactome: R-HSA-1799339;Reactome: R-HSA-381038	"SRP-dependent cotranslational protein targeting to membrane";"XBP1(S) activates chaperone genes"
Medex_00058018-RA	8	Reactome: R-HSA-68867;Reactome: R-HSA-68949;Reactome: R-HSA-68616;Reactome: R-HSA-68827;Reactome: R-HSA-68962;Reactome: R-HSA-113507;Reactome: R-HSA-68689;Reactome: R-HSA-176187	"Assembly of the pre-replicative complex";"Orc1 removal from chromatin";"Assembly of the ORC complex at the origin of replication";"CDT1 association with the CDC6:ORC:origin complex";"Activation of the pre-replicative complex";"E2F-enabled inhibition of pre-replication complex formation";"CDC6 association with the ORC:origin complex";"Activation of ATR in response to replication stress"
Medex_00025418-RA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Medex_00088591-RA	2	Reactome: R-HSA-3299685;KEGG: 00480+1.11.1.15	"Detoxification of Reactive Oxygen Species";"Glutathione metabolism"
Medex_00055389-RA	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
Medex_00051150-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00030537-RA	1	Reactome: R-HSA-5601884	"PIWI-interacting RNA (piRNA) biogenesis"
Medex_00038619-RA	7	Reactome: R-HSA-381033;Reactome: R-HSA-381042;Reactome: R-HSA-381070;Reactome: R-HSA-983170;Reactome: R-HSA-3371453;Reactome: R-HSA-114608;Reactome: R-HSA-381183	"ATF6 (ATF6-alpha) activates chaperones";"PERK regulates gene expression";"IRE1alpha activates chaperones";"Antigen Presentation: Folding, assembly and peptide loading of class I MHC";"Regulation of HSF1-mediated heat shock response";"Platelet degranulation";"ATF6 (ATF6-alpha) activates chaperone genes"
Medex_00039016-RA	2	Reactome: R-HSA-379726;KEGG: 00970+6.1.1.15	"Mitochondrial tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis"
Medex_00000121-RA	13	Reactome: R-HSA-983695;Reactome: R-HSA-139853;Reactome: R-HSA-1489509;Reactome: R-HSA-422356;Reactome: R-HSA-112043;Reactome: R-HSA-2029485;Reactome: R-HSA-5607763;Reactome: R-HSA-5578775;Reactome: R-HSA-114508;Reactome: R-HSA-2871809;Reactome: R-HSA-4086398;Reactome: R-HSA-381676;Reactome: R-HSA-5218921	"Antigen activates B Cell Receptor (BCR) leading to generation of second messengers";"Elevation of cytosolic Ca2+ levels";"DAG and IP3 signaling";"Regulation of insulin secretion";"PLC beta mediated events";"Role of phospholipids in phagocytosis";"CLEC7A (Dectin-1) induces NFAT activation";"Ion homeostasis";"Effects of PIP2 hydrolysis";"FCERI mediated Ca+2 mobilization";"Ca2+ pathway";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"VEGFR2 mediated cell proliferation"
Medex_00026903-RA	2	Reactome: R-HSA-381038;Reactome: R-HSA-1799339	"XBP1(S) activates chaperone genes";"SRP-dependent cotranslational protein targeting to membrane"
Medex_00062622-RA	1	KEGG: 00970+6.1.1.16	"Aminoacyl-tRNA biosynthesis"
Medex_00008936-RA	4	Reactome: R-HSA-8963889;Reactome: R-HSA-1655829;Reactome: R-HSA-381033;Reactome: R-HSA-8874211	"Assembly of active LPL and LIPC lipase complexes";"Regulation of cholesterol biosynthesis by SREBP (SREBF)";"ATF6 (ATF6-alpha) activates chaperones";"CREB3 factors activate genes"
Medex_00048941-RA	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
Medex_00065502-RA	17	Reactome: R-HSA-192823;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-72695;Reactome: R-HSA-156902;Reactome: R-HSA-72649;Reactome: R-HSA-72689;Reactome: R-HSA-2408557;Reactome: R-HSA-6790901;Reactome: R-HSA-975957;Reactome: R-HSA-9633012;Reactome: R-HSA-1799339;Reactome: R-HSA-72764;Reactome: R-HSA-975956;Reactome: R-HSA-72706;Reactome: R-HSA-6791226;Reactome: R-HSA-72702	"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Formation of the ternary complex, and subsequently, the 43S complex";"Peptide chain elongation";"Translation initiation complex formation";"Formation of a pool of free 40S subunits";"Selenocysteine synthesis";"rRNA modification in the nucleus and cytosol";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"SRP-dependent cotranslational protein targeting to membrane";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Major pathway of rRNA processing in the nucleolus and cytosol";"Ribosomal scanning and start codon recognition"
Medex_00036666-RA	4	Reactome: R-HSA-6781823;Reactome: R-HSA-8856825;Reactome: R-HSA-5696394;Reactome: R-HSA-8951664	"Formation of TC-NER Pre-Incision Complex";"Cargo recognition for clathrin-mediated endocytosis";"DNA Damage Recognition in GG-NER";"Neddylation"
Medex_00053557-RA	13	MetaCyc: PWY-7102;MetaCyc: PWY-7709;MetaCyc: PWY-5122;MetaCyc: PWY-5123;MetaCyc: PWY-7736;MetaCyc: PWY-7141;MetaCyc: PWY-6859;MetaCyc: PWY-7721;MetaCyc: PWY-7182;MetaCyc: PWY-7410;MetaCyc: PWY-7659;MetaCyc: PWY-6383;KEGG: 00900+2.5.1.10+2.5.1.1	"Bisabolene biosynthesis (engineered)";"(3R)-linalool biosynthesis";"Geranyl diphosphate biosynthesis";"Trans, trans-farnesyl diphosphate biosynthesis";"Stellatic acid biosynthesis";"(3S)-linalool biosynthesis";"All-trans-farnesol biosynthesis";"Methyl phomopsenoate biosynthesis";"Linalool biosynthesis I";"Ipsdienol biosynthesis";"Viridicatumtoxin biosynthesis";"Mono-trans, poly-cis decaprenyl phosphate biosynthesis";"Terpenoid backbone biosynthesis"
Medex_00021051-RA	10	KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1;Reactome: R-HSA-5689880;Reactome: R-HSA-3214847;Reactome: R-HSA-201722;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1	"Human cytomegalovirus infection";"Relaxin signaling pathway";"PI3K-Akt signaling pathway";"Ub-specific processing proteases";"HATs acetylate histones";"Formation of the beta-catenin:TCF transactivating complex";"Thermogenesis";"mTOR signaling pathway";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection"
Medex_00088927-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Medex_00003269-RA	1	Reactome: R-HSA-426117	"Cation-coupled Chloride cotransporters"
Medex_00063545-RA	22	MetaCyc: PWY-7035;MetaCyc: PWY-7049;MetaCyc: PWY-7726;MetaCyc: PWY-7619;MetaCyc: PWY-7725;KEGG: 00062+4.2.1.134;MetaCyc: PWY-7592;MetaCyc: PWY-7728;MetaCyc: PWY-7601;MetaCyc: PWY-7724;MetaCyc: PWY-6958;Reactome: R-HSA-75876;MetaCyc: PWY-5353;MetaCyc: PWY-6433;MetaCyc: PWY-7036;MetaCyc: PWY-7602;MetaCyc: PWY-6598;MetaCyc: PWY-7606;MetaCyc: PWY-8041;MetaCyc: PWY-5080;MetaCyc: PWY-7727;MetaCyc: PWY-7053	"(9Z)-tricosene biosynthesis";"Icosapentaenoate biosynthesis II (6-desaturase, mammals)";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"Juniperonate biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Fatty acid elongation";"Arachidonate biosynthesis III (6-desaturase, mammals)";"(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Icosapentaenoate biosynthesis I (lower eukaryotes)";"Synthesis of very long-chain fatty acyl-CoAs";"Arachidonate biosynthesis I (6-desaturase, lower eukaryotes)";"Hydroxylated fatty acid biosynthesis (plants)";"Very long chain fatty acid biosynthesis II";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Sciadonate biosynthesis";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Ultra-long-chain fatty acid biosynthesis";"Very long chain fatty acid biosynthesis I";"Docosahexaenoate biosynthesis IV (4-desaturase, mammals)";"Docosahexaenoate biosynthesis I (lower eukaryotes)"
Medex_00063243-RA	1	Reactome: R-HSA-1483166	"Synthesis of PA"
Medex_00039229-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Medex_00047990-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00008437-RA	1	Reactome: R-HSA-1799339	"SRP-dependent cotranslational protein targeting to membrane"
Medex_00061510-RA	3	KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16	"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway"
Medex_00078696-RA	13	Reactome: R-HSA-975957;Reactome: R-HSA-192823;Reactome: R-HSA-1799339;Reactome: R-HSA-9633012;Reactome: R-HSA-156902;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-72706;Reactome: R-HSA-975956;Reactome: R-HSA-72689;Reactome: R-HSA-72764;Reactome: R-HSA-2408557;Reactome: R-HSA-6791226	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Viral mRNA Translation";"SRP-dependent cotranslational protein targeting to membrane";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Formation of a pool of free 40S subunits";"Eukaryotic Translation Termination";"Selenocysteine synthesis";"Major pathway of rRNA processing in the nucleolus and cytosol"
Medex_00078998-RA	4	Reactome: R-HSA-5693554;Reactome: R-HSA-5693568;Reactome: R-HSA-5693579;Reactome: R-HSA-5685942	"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Resolution of D-loop Structures through Holliday Junction Intermediates";"Homologous DNA Pairing and Strand Exchange";"HDR through Homologous Recombination (HRR)"
Medex_00069349-RA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
Medex_00012291-RA	2	KEGG: 00230+2.7.4.8;MetaCyc: PWY-7221	"Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis"
Medex_00022786-RA	4	Reactome: R-HSA-382556;Reactome: R-HSA-5362768;Reactome: R-HSA-5678895;Reactome: R-HSA-5358346	"ABC-family proteins mediated transport";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Defective CFTR causes cystic fibrosis";"Hedgehog ligand biogenesis"
Medex_00032853-RA	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
Medex_00080456-RA	9	Reactome: R-HSA-69205;Reactome: R-HSA-174430;Reactome: R-HSA-69166;Reactome: R-HSA-68962;Reactome: R-HSA-113501;Reactome: R-HSA-174411;Reactome: R-HSA-69183;Reactome: R-HSA-69091;Reactome: R-HSA-68952	"G1/S-Specific Transcription";"Telomere C-strand synthesis initiation";"Removal of the Flap Intermediate";"Activation of the pre-replicative complex";"Inhibition of replication initiation of damaged DNA by RB1/E2F1";"Polymerase switching on the C-strand of the telomere";"Processive synthesis on the lagging strand";"Polymerase switching";"DNA replication initiation"
Medex_00061897-RA	6	MetaCyc: PWY-6733;MetaCyc: PWY-7782;MetaCyc: PWY-7656;KEGG: 00073+1.2.1.84;MetaCyc: PWY-5884;Reactome: R-HSA-9640463	"Sporopollenin precursors biosynthesis";"Plasmalogen biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax esters biosynthesis I";"Wax biosynthesis"
Medex_00093270-RA	2	Reactome: R-HSA-390471;Reactome: R-HSA-1660662	"Association of TriC/CCT with target proteins during biosynthesis";"Glycosphingolipid metabolism"
Medex_00021159-RA	2	Reactome: R-HSA-418457;Reactome: R-HSA-4086398	"cGMP effects";"Ca2+ pathway"
Medex_00019788-RA	2	Reactome: R-HSA-6811436;Reactome: R-HSA-8876198	"COPI-independent Golgi-to-ER retrograde traffic";"RAB GEFs exchange GTP for GDP on RABs"
Medex_00012451-RA	5	MetaCyc: PWY-6123;KEGG: 00230+6.3.2.6;MetaCyc: PWY-6124;Reactome: R-HSA-73817;MetaCyc: PWY-7234	"Inosine-5'-phosphate biosynthesis I";"Purine metabolism";"Inosine-5'-phosphate biosynthesis II";"Purine ribonucleoside monophosphate biosynthesis";"Inosine-5'-phosphate biosynthesis III"
Medex_00093426-RA	13	Reactome: R-HSA-6791226;Reactome: R-HSA-2408557;Reactome: R-HSA-72764;Reactome: R-HSA-72689;Reactome: R-HSA-72706;Reactome: R-HSA-975956;Reactome: R-HSA-156902;Reactome: R-HSA-9633012;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-1799339;Reactome: R-HSA-192823;Reactome: R-HSA-975957	"Major pathway of rRNA processing in the nucleolus and cytosol";"Selenocysteine synthesis";"Eukaryotic Translation Termination";"Formation of a pool of free 40S subunits";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Peptide chain elongation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"SRP-dependent cotranslational protein targeting to membrane";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
Medex_00030318-RA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
Medex_00065682-RA	8	MetaCyc: PWY-6142;MetaCyc: PWY-5743;MetaCyc: PWY-241;MetaCyc: PWY-7117;MetaCyc: PWY-5744;MetaCyc: PWY-7115;MetaCyc: PWY-5789;KEGG: 00910+4.2.1.1	"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"3-hydroxypropanoate cycle";"C4 photosynthetic carbon assimilation cycle, NADP-ME type";"C4 photosynthetic carbon assimilation cycle, PEPCK type";"Glyoxylate assimilation";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Nitrogen metabolism"
Medex_00070341-RA	1	Reactome: R-HSA-8854214	"TBC/RABGAPs"
Medex_00059579-RA	1	Reactome: R-HSA-156584	"Cytosolic sulfonation of small molecules"
Medex_00090004-RA	7	Reactome: R-HSA-9018519;Reactome: R-HSA-2467813;Reactome: R-HSA-2470946;Reactome: R-HSA-2468052;Reactome: R-HSA-2500257;Reactome: R-HSA-1221632;Reactome: R-HSA-3108214	"Estrogen-dependent gene expression";"Separation of Sister Chromatids";"Cohesin Loading onto Chromatin";"Establishment of Sister Chromatid Cohesion";"Resolution of Sister Chromatid Cohesion";"Meiotic synapsis";"SUMOylation of DNA damage response and repair proteins"
Medex_00098860-RA	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
Medex_00052456-RA	2	Reactome: R-HSA-162710;KEGG: 00563+2.4.1.198	"Synthesis of glycosylphosphatidylinositol (GPI)";"Glycosylphosphatidylinositol (GPI)-anchor biosynthesis"
Medex_00050744-RA	2	Reactome: R-HSA-8853659;Reactome: R-HSA-5673001	"RET signaling";"RAF/MAP kinase cascade"
Medex_00046720-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00037897-RA	2	Reactome: R-HSA-8964038;Reactome: R-HSA-6798695	"LDL clearance";"Neutrophil degranulation"
Medex_00030917-RA	5	Reactome: R-HSA-196108;Reactome: R-HSA-211976;Reactome: R-HSA-2395516;Reactome: R-HSA-1362409;Reactome: R-HSA-5579026	"Pregnenolone biosynthesis";"Endogenous sterols";"Electron transport from NADPH to Ferredoxin";"Mitochondrial iron-sulfur cluster biogenesis";"Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)"
Medex_00036381-RA	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
Medex_00010753-RA	1	Reactome: R-HSA-70921	"Histidine catabolism"
Medex_00044027-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Medex_00042978-RA	1	KEGG: 00970+6.1.1.14	"Aminoacyl-tRNA biosynthesis"
Medex_00024673-RA	3	MetaCyc: PWY-6348;KEGG: 00730+3.1.3.2;KEGG: 00740+3.1.3.2	"Phosphate acquisition";"Thiamine metabolism";"Riboflavin metabolism"
Medex_00091818-RA	4	Reactome: R-HSA-1614558;MetaCyc: PWY-5331;KEGG: 00430+1.13.11.20;KEGG: 00270+1.13.11.20	"Degradation of cysteine and homocysteine";"Taurine biosynthesis I";"Taurine and hypotaurine metabolism";"Cysteine and methionine metabolism"
Medex_00102750-RA	27	Reactome: R-HSA-111367;Reactome: R-HSA-159230;Reactome: R-HSA-167200;Reactome: R-HSA-72165;Reactome: R-HSA-72163;Reactome: R-HSA-167242;Reactome: R-HSA-73856;Reactome: R-HSA-159231;Reactome: R-HSA-167152;Reactome: R-HSA-674695;Reactome: R-HSA-9010553;Reactome: R-HSA-159227;Reactome: R-HSA-77595;Reactome: R-HSA-72187;Reactome: R-HSA-72086;Reactome: R-HSA-975956;Reactome: R-HSA-112382;Reactome: R-HSA-8851708;Reactome: R-HSA-77588;Reactome: R-HSA-191859;Reactome: R-HSA-159236;Reactome: R-HSA-72203;Reactome: R-HSA-167158;Reactome: R-HSA-975957;Reactome: R-HSA-6807505;Reactome: R-HSA-113418;Reactome: R-HSA-6803529	"SLBP independent Processing of Histone Pre-mRNAs";"Transport of the SLBP Dependant Mature mRNA";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"mRNA Splicing - Minor Pathway";"mRNA Splicing - Major Pathway";"Abortive elongation of HIV-1 transcript in the absence of Tat";"RNA Polymerase II Transcription Termination";"Transport of Mature mRNA Derived from an Intronless Transcript";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Polymerase II Pre-transcription Events";"Regulation of expression of SLITs and ROBOs";"Transport of the SLBP independent Mature mRNA";"Processing of Intronless Pre-mRNAs";"mRNA 3'-end processing";"mRNA Capping";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Formation of RNA Pol II elongation complex";"Signaling by FGFR2 IIIa TM";"SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs";"snRNP Assembly";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Processing of Capped Intron-Containing Pre-mRNA";"Formation of the HIV-1 Early Elongation Complex";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"RNA polymerase II transcribes snRNA genes";"Formation of the Early Elongation Complex";"FGFR2 alternative splicing"
Medex_00080879-RA	1	Reactome: R-HSA-6798163	"Choline catabolism"
Medex_00033975-RA	1	KEGG: 00970+6.1.1.7	"Aminoacyl-tRNA biosynthesis"
Medex_00023283-RA	2	Reactome: R-HSA-3214858;Reactome: R-HSA-8939243	"RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"
Medex_00079644-RA	3	Reactome: R-HSA-418359;Reactome: R-HSA-936837;Reactome: R-HSA-5578775	"Reduction of cytosolic Ca++ levels";"Ion transport by P-type ATPases";"Ion homeostasis"
Medex_00014245-RA	56	Reactome: R-HSA-195253;Reactome: R-HSA-75815;Reactome: R-HSA-8939902;Reactome: R-HSA-4608870;Reactome: R-HSA-5689603;Reactome: R-HSA-5687128;Reactome: R-HSA-5668541;Reactome: R-HSA-5689880;Reactome: R-HSA-5610785;Reactome: R-HSA-180534;Reactome: R-HSA-1236978;Reactome: R-HSA-349425;Reactome: R-HSA-5632684;Reactome: R-HSA-174178;Reactome: R-HSA-8852276;Reactome: R-HSA-5610780;Reactome: R-HSA-5607761;Reactome: R-HSA-202424;Reactome: R-HSA-983168;Reactome: R-HSA-5358346;Reactome: R-HSA-8941858;Reactome: R-HSA-5658442;Reactome: R-HSA-9020702;Reactome: R-HSA-450408;Reactome: R-HSA-180585;Reactome: R-HSA-2467813;Reactome: R-HSA-4641258;Reactome: R-HSA-8939236;Reactome: R-HSA-211733;Reactome: R-HSA-382556;Reactome: R-HSA-68949;Reactome: R-HSA-9010553;Reactome: R-HSA-4641257;Reactome: R-HSA-174113;Reactome: R-HSA-350562;Reactome: R-HSA-5678895;Reactome: R-HSA-69481;Reactome: R-HSA-68827;Reactome: R-HSA-8948751;Reactome: R-HSA-9604323;Reactome: R-HSA-5676590;Reactome: R-HSA-1234176;Reactome: R-HSA-5362768;Reactome: R-HSA-69017;Reactome: R-HSA-69601;Reactome: R-HSA-174184;Reactome: R-HSA-5607764;Reactome: R-HSA-174154;Reactome: R-HSA-1169091;Reactome: R-HSA-2871837;Reactome: R-HSA-8951664;Reactome: R-HSA-174084;Reactome: R-HSA-187577;Reactome: R-HSA-8854050;Reactome: R-HSA-1236974;Reactome: R-HSA-5610783	"Degradation of beta-catenin by the destruction complex";"Ubiquitin-dependent degradation of Cyclin D";"Regulation of RUNX2 expression and activity";"Asymmetric localization of PCP proteins";"UCH proteinases";"MAPK6/MAPK4 signaling";"TNFR2 non-canonical NF-kB pathway";"Ub-specific processing proteases";"GLI3 is processed to GLI3R by the proteasome";"Vpu mediated degradation of CD4";"Cross-presentation of soluble exogenous antigens (endosomes)";"Autodegradation of the E3 ubiquitin ligase COP1";"Hedgehog 'on' state";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Degradation of GLI1 by the proteasome";"Dectin-1 mediated noncanonical NF-kB signaling";"Downstream TCR signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Hedgehog ligand biogenesis";"Regulation of RUNX3 expression and activity";"Regulation of RAS by GAPs";"Interleukin-1 signaling";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Vif-mediated degradation of APOBEC3G";"Separation of Sister Chromatids";"Degradation of DVL";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"ABC-family proteins mediated transport";"Orc1 removal from chromatin";"Regulation of expression of SLITs and ROBOs";"Degradation of AXIN";"SCF-beta-TrCP mediated degradation of Emi1";"Regulation of ornithine decarboxylase (ODC)";"Defective CFTR causes cystic fibrosis";"G2/M Checkpoints";"CDT1 association with the CDC6:ORC:origin complex";"Regulation of PTEN stability and activity";"Negative regulation of NOTCH4 signaling";"NIK-->noncanonical NF-kB signaling";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"CDK-mediated phosphorylation and removal of Cdc6";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"CLEC7A (Dectin-1) signaling";"APC/C:Cdc20 mediated degradation of Securin";"Activation of NF-kappaB in B cells";"FCERI mediated NF-kB activation";"Neddylation";"Autodegradation of Cdh1 by Cdh1:APC/C";"SCF(Skp2)-mediated degradation of p27/p21";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"ER-Phagosome pathway";"Degradation of GLI2 by the proteasome"
Medex_00039477-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Medex_00030303-RA	2	Reactome: R-HSA-8951664;Reactome: R-HSA-983168	"Neddylation";"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00021476-RA	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
Medex_00022326-RA	1	Reactome: R-HSA-1474228	"Degradation of the extracellular matrix"
Medex_00000018-RA	5	Reactome: R-HSA-4341670;Reactome: R-HSA-4085001;Reactome: R-HSA-1660662;Reactome: R-HSA-6798695;Reactome: R-HSA-2132295	"Defective NEU1 causes sialidosis";"Sialic acid metabolism";"Glycosphingolipid metabolism";"Neutrophil degranulation";"MHC class II antigen presentation"
Medex_00070319-RA	17	Reactome: R-HSA-1538133;Reactome: R-HSA-139915;Reactome: R-HSA-69231;Reactome: R-HSA-69205;Reactome: R-HSA-1362300;Reactome: R-HSA-2173796;Reactome: R-HSA-1912408;Reactome: R-HSA-2559585;Reactome: R-HSA-8953750;Reactome: R-HSA-9616222;Reactome: R-HSA-1362277;Reactome: R-HSA-69202;Reactome: R-HSA-6804114;Reactome: R-HSA-2559580;Reactome: R-HSA-113501;Reactome: R-HSA-111448;Reactome: R-HSA-69656	"G0 and Early G1";"Activation of PUMA and translocation to mitochondria";"Cyclin D associated events in G1";"G1/S-Specific Transcription";"Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"Pre-NOTCH Transcription and Translation";"Oncogene Induced Senescence";"Transcriptional Regulation by E2F6";"Transcriptional regulation of granulopoiesis";"Transcription of E2F targets under negative control by DREAM complex";"Cyclin E associated events during G1/S transition";"TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest";"Oxidative Stress Induced Senescence";"Inhibition of replication initiation of damaged DNA by RB1/E2F1";"Activation of NOXA and translocation to mitochondria";"Cyclin A:Cdk2-associated events at S phase entry"
Medex_00069972-RA	5	Reactome: R-HSA-191273;KEGG: 00900+2.7.4.2;MetaCyc: PWY-922;Reactome: R-HSA-2426168;MetaCyc: PWY-7391	"Cholesterol biosynthesis";"Terpenoid backbone biosynthesis";"Mevalonate pathway I";"Activation of gene expression by SREBF (SREBP)";"Isoprene biosynthesis II (engineered)"
Medex_00073420-RA	1	Reactome: R-HSA-1362409	"Mitochondrial iron-sulfur cluster biogenesis"
Medex_00056205-RA	2	MetaCyc: PWY-7799;MetaCyc: PWY-7800	"Arg/N-end rule pathway (eukaryotic)";"Ac/N-end rule pathway"
Medex_00003633-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00095365-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00001713-RA	2	Reactome: R-HSA-8866423;Reactome: R-HSA-8963888	"VLDL assembly";"Chylomicron assembly"
Medex_00020319-RA	6	Reactome: R-HSA-9640463;MetaCyc: PWY-5884;KEGG: 00073+1.2.1.84;MetaCyc: PWY-6733;MetaCyc: PWY-7782;MetaCyc: PWY-7656	"Wax biosynthesis";"Wax esters biosynthesis I";"Cutin, suberine and wax biosynthesis";"Sporopollenin precursors biosynthesis";"Plasmalogen biosynthesis";"Spodoptera littoralis pheromone biosynthesis"
Medex_00078208-RA	7	Reactome: R-HSA-446193;MetaCyc: PWY-6471;MetaCyc: PWY-6470;Reactome: R-HSA-4549356;KEGG: 00550+2.7.8.13;MetaCyc: PWY-5265;KEGG: 00510+2.7.8.15	"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"Peptidoglycan biosynthesis IV (Enterococcus faecium)";"Peptidoglycan biosynthesis V (beta-lactam resistance)";"Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2";"Peptidoglycan biosynthesis";"Peptidoglycan biosynthesis II (staphylococci)";"N-Glycan biosynthesis"
Medex_00019944-RA	27	Reactome: R-HSA-3232142;Reactome: R-HSA-3301854;Reactome: R-HSA-180910;Reactome: R-HSA-168271;Reactome: R-HSA-170822;Reactome: R-HSA-4570464;Reactome: R-HSA-4085377;Reactome: R-HSA-4551638;Reactome: R-HSA-9609690;Reactome: R-HSA-5619107;Reactome: R-HSA-9610379;Reactome: R-HSA-168325;Reactome: R-HSA-159236;Reactome: R-HSA-191859;Reactome: R-HSA-3108214;Reactome: R-HSA-6784531;Reactome: R-HSA-165054;Reactome: R-HSA-1169408;Reactome: R-HSA-168333;Reactome: R-HSA-180746;Reactome: R-HSA-159227;Reactome: R-HSA-159231;Reactome: R-HSA-3371453;Reactome: R-HSA-4615885;Reactome: R-HSA-159230;Reactome: R-HSA-168276;Reactome: R-HSA-5578749	"SUMOylation of ubiquitinylation proteins";"Nuclear Pore Complex (NPC) Disassembly";"Vpr-mediated nuclear import of PICs";"Transport of Ribonucleoproteins into the Host Nucleus";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"SUMOylation of RNA binding proteins";"SUMOylation of SUMOylation proteins";"SUMOylation of chromatin organization proteins";"HCMV Early Events";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"HCMV Late Events";"Viral Messenger RNA Synthesis";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"snRNP Assembly";"SUMOylation of DNA damage response and repair proteins";"tRNA processing in the nucleus";"Rev-mediated nuclear export of HIV RNA";"ISG15 antiviral mechanism";"NEP/NS2 Interacts with the Cellular Export Machinery";"Nuclear import of Rev protein";"Transport of the SLBP independent Mature mRNA";"Transport of Mature mRNA Derived from an Intronless Transcript";"Regulation of HSF1-mediated heat shock response";"SUMOylation of DNA replication proteins";"Transport of the SLBP Dependant Mature mRNA";"NS1 Mediated Effects on Host Pathways";"Transcriptional regulation by small RNAs"
Medex_00085479-RA	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
Medex_00010148-RA	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
Medex_00102897-RA	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
Medex_00000174-RA	16	Reactome: R-HSA-69017;Reactome: R-HSA-176407;Reactome: R-HSA-176412;Reactome: R-HSA-174178;Reactome: R-HSA-174184;Reactome: R-HSA-174154;Reactome: R-HSA-8853884;Reactome: R-HSA-174084;Reactome: R-HSA-2559582;Reactome: R-HSA-176408;Reactome: R-HSA-174048;Reactome: R-HSA-983168;Reactome: R-HSA-141430;Reactome: R-HSA-179409;Reactome: R-HSA-176409;Reactome: R-HSA-2467813	"CDK-mediated phosphorylation and removal of Cdc6";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"Phosphorylation of the APC/C";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"APC/C:Cdc20 mediated degradation of Securin";"Transcriptional Regulation by VENTX";"Autodegradation of Cdh1 by Cdh1:APC/C";"Senescence-Associated Secretory Phenotype (SASP)";"Regulation of APC/C activators between G1/S and early anaphase";"APC/C:Cdc20 mediated degradation of Cyclin B";"Antigen processing: Ubiquitination & Proteasome degradation";"Inactivation of APC/C via direct inhibition of the APC/C complex";"APC-Cdc20 mediated degradation of Nek2A";"APC/C:Cdc20 mediated degradation of mitotic proteins";"Separation of Sister Chromatids"
Medex_00004852-RA	2	Reactome: R-HSA-425366;Reactome: R-HSA-1483191	"Transport of bile salts and organic acids, metal ions and amine compounds";"Synthesis of PC"
Medex_00003373-RA	2	Reactome: R-HSA-70350;Reactome: R-HSA-168928	"Fructose catabolism";"DDX58/IFIH1-mediated induction of interferon-alpha/beta"
Medex_00006071-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Medex_00022319-RA	3	KEGG: 00730+3.1.3.1;MetaCyc: PWY-5491;KEGG: 00790+3.1.3.1	"Thiamine metabolism";"Diethylphosphate degradation";"Folate biosynthesis"
Medex_00096212-RA	4	KEGG: 00513+2.4.1.258;KEGG: 00510+2.4.1.258;Reactome: R-HSA-446193;Reactome: R-HSA-4720475	"Various types of N-glycan biosynthesis";"N-Glycan biosynthesis";"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"Defective ALG3 causes ALG3-CDG (CDG-1d)"
Medex_00013039-RA	1	Reactome: R-HSA-203927	"MicroRNA (miRNA) biogenesis"
Medex_00024511-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Medex_00099419-RA	1	Reactome: R-HSA-6803157	"Antimicrobial peptides"
Medex_00088930-RA	1	Reactome: R-HSA-6803207	"TP53 Regulates Transcription of Caspase Activators and Caspases"
Medex_00026369-RA	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
Medex_00009877-RA	6	Reactome: R-HSA-5693565;Reactome: R-HSA-8939211;KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16;Reactome: R-HSA-5675221;KEGG: 04660+3.1.3.16	"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"ESR-mediated signaling";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation";"Negative regulation of MAPK pathway";"T cell receptor signaling pathway"
Medex_00098037-RA	3	KEGG: 00730+3.1.3.1;MetaCyc: PWY-5491;KEGG: 00790+3.1.3.1	"Thiamine metabolism";"Diethylphosphate degradation";"Folate biosynthesis"
Medex_00025414-RA	3	KEGG: 00230+3.5.4.6;MetaCyc: PWY-6596;Reactome: R-HSA-74217	"Purine metabolism";"Adenosine nucleotides degradation I";"Purine salvage"
Medex_00033408-RA	3	Reactome: R-HSA-9033241;Reactome: R-HSA-9603798;Reactome: R-HSA-8866654	"Peroxisomal protein import";"Class I peroxisomal membrane protein import";"E3 ubiquitin ligases ubiquitinate target proteins"
Medex_00012211-RA	57	Reactome: R-HSA-187577;Reactome: R-HSA-174084;Reactome: R-HSA-1236974;Reactome: R-HSA-8854050;Reactome: R-HSA-5610783;Reactome: R-HSA-68827;Reactome: R-HSA-8948751;Reactome: R-HSA-9604323;Reactome: R-HSA-1234176;Reactome: R-HSA-69017;Reactome: R-HSA-5362768;Reactome: R-HSA-69601;Reactome: R-HSA-5676590;Reactome: R-HSA-174113;Reactome: R-HSA-4641257;Reactome: R-HSA-350562;Reactome: R-HSA-5678895;Reactome: R-HSA-69481;Reactome: R-HSA-8951664;Reactome: R-HSA-2871837;Reactome: R-HSA-5607764;Reactome: R-HSA-174184;Reactome: R-HSA-1169091;Reactome: R-HSA-174154;Reactome: R-HSA-6798695;Reactome: R-HSA-9020702;Reactome: R-HSA-983168;Reactome: R-HSA-202424;Reactome: R-HSA-5658442;Reactome: R-HSA-5358346;Reactome: R-HSA-8941858;Reactome: R-HSA-9010553;Reactome: R-HSA-211733;Reactome: R-HSA-382556;Reactome: R-HSA-68949;Reactome: R-HSA-8939236;Reactome: R-HSA-180585;Reactome: R-HSA-450408;Reactome: R-HSA-4641258;Reactome: R-HSA-2467813;Reactome: R-HSA-5687128;Reactome: R-HSA-5689603;Reactome: R-HSA-5668541;Reactome: R-HSA-4608870;Reactome: R-HSA-5610785;Reactome: R-HSA-5689880;Reactome: R-HSA-195253;Reactome: R-HSA-8939902;Reactome: R-HSA-75815;Reactome: R-HSA-174178;Reactome: R-HSA-5607761;Reactome: R-HSA-5610780;Reactome: R-HSA-8852276;Reactome: R-HSA-349425;Reactome: R-HSA-1236978;Reactome: R-HSA-180534;Reactome: R-HSA-5632684	"SCF(Skp2)-mediated degradation of p27/p21";"Autodegradation of Cdh1 by Cdh1:APC/C";"ER-Phagosome pathway";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Degradation of GLI2 by the proteasome";"CDT1 association with the CDC6:ORC:origin complex";"Regulation of PTEN stability and activity";"Negative regulation of NOTCH4 signaling";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"CDK-mediated phosphorylation and removal of Cdc6";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"NIK-->noncanonical NF-kB signaling";"SCF-beta-TrCP mediated degradation of Emi1";"Degradation of AXIN";"Regulation of ornithine decarboxylase (ODC)";"Defective CFTR causes cystic fibrosis";"G2/M Checkpoints";"Neddylation";"FCERI mediated NF-kB activation";"CLEC7A (Dectin-1) signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Activation of NF-kappaB in B cells";"APC/C:Cdc20 mediated degradation of Securin";"Neutrophil degranulation";"Interleukin-1 signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Downstream TCR signaling";"Regulation of RAS by GAPs";"Hedgehog ligand biogenesis";"Regulation of RUNX3 expression and activity";"Regulation of expression of SLITs and ROBOs";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"ABC-family proteins mediated transport";"Orc1 removal from chromatin";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Vif-mediated degradation of APOBEC3G";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Degradation of DVL";"Separation of Sister Chromatids";"MAPK6/MAPK4 signaling";"UCH proteinases";"TNFR2 non-canonical NF-kB pathway";"Asymmetric localization of PCP proteins";"GLI3 is processed to GLI3R by the proteasome";"Ub-specific processing proteases";"Degradation of beta-catenin by the destruction complex";"Regulation of RUNX2 expression and activity";"Ubiquitin-dependent degradation of Cyclin D";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Dectin-1 mediated noncanonical NF-kB signaling";"Degradation of GLI1 by the proteasome";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Autodegradation of the E3 ubiquitin ligase COP1";"Cross-presentation of soluble exogenous antigens (endosomes)";"Vpu mediated degradation of CD4";"Hedgehog 'on' state"
Medex_00047371-RA	5	Reactome: R-HSA-159236;Reactome: R-HSA-72165;Reactome: R-HSA-72187;Reactome: R-HSA-73856;Reactome: R-HSA-72163	"Transport of Mature mRNA derived from an Intron-Containing Transcript";"mRNA Splicing - Minor Pathway";"mRNA 3'-end processing";"RNA Polymerase II Transcription Termination";"mRNA Splicing - Major Pathway"
Medex_00044133-RA	56	Reactome: R-HSA-2871837;Reactome: R-HSA-8951664;Reactome: R-HSA-174154;Reactome: R-HSA-1169091;Reactome: R-HSA-5607764;Reactome: R-HSA-174184;Reactome: R-HSA-5676590;Reactome: R-HSA-1234176;Reactome: R-HSA-5362768;Reactome: R-HSA-69017;Reactome: R-HSA-69601;Reactome: R-HSA-68827;Reactome: R-HSA-8948751;Reactome: R-HSA-9604323;Reactome: R-HSA-5678895;Reactome: R-HSA-350562;Reactome: R-HSA-69481;Reactome: R-HSA-4641257;Reactome: R-HSA-174113;Reactome: R-HSA-5610783;Reactome: R-HSA-8854050;Reactome: R-HSA-1236974;Reactome: R-HSA-174084;Reactome: R-HSA-187577;Reactome: R-HSA-8852276;Reactome: R-HSA-5610780;Reactome: R-HSA-5607761;Reactome: R-HSA-174178;Reactome: R-HSA-5632684;Reactome: R-HSA-180534;Reactome: R-HSA-349425;Reactome: R-HSA-1236978;Reactome: R-HSA-5610785;Reactome: R-HSA-5689880;Reactome: R-HSA-4608870;Reactome: R-HSA-5689603;Reactome: R-HSA-5687128;Reactome: R-HSA-5668541;Reactome: R-HSA-75815;Reactome: R-HSA-8939902;Reactome: R-HSA-195253;Reactome: R-HSA-68949;Reactome: R-HSA-8939236;Reactome: R-HSA-382556;Reactome: R-HSA-211733;Reactome: R-HSA-9010553;Reactome: R-HSA-2467813;Reactome: R-HSA-4641258;Reactome: R-HSA-450408;Reactome: R-HSA-180585;Reactome: R-HSA-9020702;Reactome: R-HSA-5358346;Reactome: R-HSA-8941858;Reactome: R-HSA-5658442;Reactome: R-HSA-202424;Reactome: R-HSA-983168	"FCERI mediated NF-kB activation";"Neddylation";"APC/C:Cdc20 mediated degradation of Securin";"Activation of NF-kappaB in B cells";"CLEC7A (Dectin-1) signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"NIK-->noncanonical NF-kB signaling";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"CDK-mediated phosphorylation and removal of Cdc6";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"CDT1 association with the CDC6:ORC:origin complex";"Regulation of PTEN stability and activity";"Negative regulation of NOTCH4 signaling";"Defective CFTR causes cystic fibrosis";"Regulation of ornithine decarboxylase (ODC)";"G2/M Checkpoints";"Degradation of AXIN";"SCF-beta-TrCP mediated degradation of Emi1";"Degradation of GLI2 by the proteasome";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"ER-Phagosome pathway";"Autodegradation of Cdh1 by Cdh1:APC/C";"SCF(Skp2)-mediated degradation of p27/p21";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Degradation of GLI1 by the proteasome";"Dectin-1 mediated noncanonical NF-kB signaling";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Hedgehog 'on' state";"Vpu mediated degradation of CD4";"Autodegradation of the E3 ubiquitin ligase COP1";"Cross-presentation of soluble exogenous antigens (endosomes)";"GLI3 is processed to GLI3R by the proteasome";"Ub-specific processing proteases";"Asymmetric localization of PCP proteins";"UCH proteinases";"MAPK6/MAPK4 signaling";"TNFR2 non-canonical NF-kB pathway";"Ubiquitin-dependent degradation of Cyclin D";"Regulation of RUNX2 expression and activity";"Degradation of beta-catenin by the destruction complex";"Orc1 removal from chromatin";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"ABC-family proteins mediated transport";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Regulation of expression of SLITs and ROBOs";"Separation of Sister Chromatids";"Degradation of DVL";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Vif-mediated degradation of APOBEC3G";"Interleukin-1 signaling";"Hedgehog ligand biogenesis";"Regulation of RUNX3 expression and activity";"Regulation of RAS by GAPs";"Downstream TCR signaling";"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00064635-RA	2	Reactome: R-HSA-936837;Reactome: R-HSA-6798695	"Ion transport by P-type ATPases";"Neutrophil degranulation"
Medex_00046566-RA	2	Reactome: R-HSA-3238698;Reactome: R-HSA-373080	"WNT ligand biogenesis and trafficking";"Class B/2 (Secretin family receptors)"
Medex_00049874-RA	4	Reactome: R-HSA-189451;MetaCyc: PWY-5188;KEGG: 00860+2.5.1.61;MetaCyc: PWY-5189	"Heme biosynthesis";"Tetrapyrrole biosynthesis I (from glutamate)";"Porphyrin and chlorophyll metabolism";"Tetrapyrrole biosynthesis II (from glycine)"
Medex_00055914-RA	7	Reactome: R-HSA-8854518;Reactome: R-HSA-380320;Reactome: R-HSA-380270;Reactome: R-HSA-2565942;Reactome: R-HSA-380259;Reactome: R-HSA-380284;Reactome: R-HSA-5620912	"AURKA Activation by TPX2";"Recruitment of NuMA to mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes";"Regulation of PLK1 Activity at G2/M Transition";"Loss of Nlp from mitotic centrosomes";"Loss of proteins required for interphase microtubule organization from the centrosome";"Anchoring of the basal body to the plasma membrane"
Medex_00003833-RA	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
Medex_00054798-RA	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5419276;Reactome: R-HSA-5389840	"Mitochondrial translation initiation";"Mitochondrial translation termination";"Mitochondrial translation elongation"
Medex_00064880-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Medex_00017446-RA	5	Reactome: R-HSA-8856828;Reactome: R-HSA-190873;Reactome: R-HSA-196025;Reactome: R-HSA-3928665;Reactome: R-HSA-8856825	"Clathrin-mediated endocytosis";"Gap junction degradation";"Formation of annular gap junctions";"EPH-ephrin mediated repulsion of cells";"Cargo recognition for clathrin-mediated endocytosis"
Medex_00053773-RA	1	Reactome: R-HSA-8856828	"Clathrin-mediated endocytosis"
Medex_00043679-RA	1	Reactome: R-HSA-6811440	"Retrograde transport at the Trans-Golgi-Network"
Medex_00070750-RA	1	Reactome: R-HSA-420499	"Class C/3 (Metabotropic glutamate/pheromone receptors)"
Medex_00067233-RA	2	Reactome: R-HSA-5205685;Reactome: R-HSA-1268020	"Pink/Parkin Mediated Mitophagy";"Mitochondrial protein import"
Medex_00020299-RA	1	Reactome: R-HSA-71064	"Lysine catabolism"
Medex_00085171-RA	12	Reactome: R-HSA-2467813;Reactome: R-HSA-9646399;Reactome: R-HSA-68877;Reactome: R-HSA-9648025;Reactome: R-HSA-5663220;Reactome: R-HSA-6807878;Reactome: R-HSA-6811436;Reactome: R-HSA-9609690;Reactome: R-HSA-141444;Reactome: R-HSA-2500257;Reactome: R-HSA-3371497;Reactome: R-HSA-2132295	"Separation of Sister Chromatids";"Aggrephagy";"Mitotic Prometaphase";"EML4 and NUDC in mitotic spindle formation";"RHO GTPases Activate Formins";"COPI-mediated anterograde transport";"COPI-independent Golgi-to-ER retrograde traffic";"HCMV Early Events";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Resolution of Sister Chromatid Cohesion";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"MHC class II antigen presentation"
Medex_00019538-RA	10	MetaCyc: PWY-8053;Reactome: R-HSA-1483166;KEGG: 00564+2.3.1.15;MetaCyc: PWY-8051;MetaCyc: PWY-6453;MetaCyc: PWY-5667;MetaCyc: PWY-8055;KEGG: 00561+2.3.1.15;MetaCyc: PWY-7411;MetaCyc: PWY-7587	"Anandamide biosynthesis II";"Synthesis of PA";"Glycerophospholipid metabolism";"Anandamide biosynthesis I";"Stigma estolide biosynthesis";"CDP-diacylglycerol biosynthesis I";"Palmitoyl ethanolamide biosynthesis";"Glycerolipid metabolism";"Phosphatidate biosynthesis (yeast)";"Oleate biosynthesis III (cyanobacteria)"
Medex_00044029-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Medex_00009033-RA	16	Reactome: R-HSA-176407;Reactome: R-HSA-69017;Reactome: R-HSA-174184;Reactome: R-HSA-174154;Reactome: R-HSA-8853884;Reactome: R-HSA-176412;Reactome: R-HSA-174178;Reactome: R-HSA-174048;Reactome: R-HSA-176408;Reactome: R-HSA-983168;Reactome: R-HSA-141430;Reactome: R-HSA-174084;Reactome: R-HSA-2559582;Reactome: R-HSA-179409;Reactome: R-HSA-2467813;Reactome: R-HSA-176409	"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"CDK-mediated phosphorylation and removal of Cdc6";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"APC/C:Cdc20 mediated degradation of Securin";"Transcriptional Regulation by VENTX";"Phosphorylation of the APC/C";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"APC/C:Cdc20 mediated degradation of Cyclin B";"Regulation of APC/C activators between G1/S and early anaphase";"Antigen processing: Ubiquitination & Proteasome degradation";"Inactivation of APC/C via direct inhibition of the APC/C complex";"Autodegradation of Cdh1 by Cdh1:APC/C";"Senescence-Associated Secretory Phenotype (SASP)";"APC-Cdc20 mediated degradation of Nek2A";"Separation of Sister Chromatids";"APC/C:Cdc20 mediated degradation of mitotic proteins"
Medex_00002588-RA	1	Reactome: R-HSA-5662702	"Melanin biosynthesis"
Medex_00074424-RA	6	MetaCyc: PWY-6737;KEGG: 00500+2.4.1.1;MetaCyc: PWY-5941;MetaCyc: PWY-6731;MetaCyc: PWY-7238;Reactome: R-HSA-70221	"Starch degradation V";"Starch and sucrose metabolism";"Glycogen degradation II";"Starch degradation III";"Sucrose biosynthesis II";"Glycogen breakdown (glycogenolysis)"
Medex_00001177-RA	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00075922-RA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
Medex_00060125-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Medex_00035914-RA	1	Reactome: R-HSA-375276	"Peptide ligand-binding receptors"
Medex_00007663-RA	1	Reactome: R-HSA-8949613	"Cristae formation"
Medex_00006909-RA	5	Reactome: R-HSA-204005;Reactome: R-HSA-6811434;Reactome: R-HSA-6811438;Reactome: R-HSA-6811440;Reactome: R-HSA-6807878	"COPII-mediated vesicle transport";"COPI-dependent Golgi-to-ER retrograde traffic";"Intra-Golgi traffic";"Retrograde transport at the Trans-Golgi-Network";"COPI-mediated anterograde transport"
Medex_00018515-RA	3	MetaCyc: PWY-6807;KEGG: 00511+3.2.1.51;Reactome: R-HSA-6798695	"Xyloglucan degradation II (exoglucanase)";"Other glycan degradation";"Neutrophil degranulation"
Medex_00066570-RA	3	MetaCyc: PWY-7159;KEGG: 00860+1.3.3.3;Reactome: R-HSA-189451	"3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent)";"Porphyrin and chlorophyll metabolism";"Heme biosynthesis"
Medex_00038760-RA	1	Reactome: R-HSA-75153	"Apoptotic execution phase"
Medex_00069909-RA	5	KEGG: 00564+1.1.1.94;MetaCyc: PWY-5981;MetaCyc: PWY-7902;MetaCyc: PWY-5667;Reactome: R-HSA-1483166	"Glycerophospholipid metabolism";"CDP-diacylglycerol biosynthesis III";"Glucosylglycerol biosynthesis";"CDP-diacylglycerol biosynthesis I";"Synthesis of PA"
Medex_00083982-RA	3	Reactome: R-HSA-8951664;Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Neddylation";"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
Medex_00032262-RA	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
Medex_00065444-RA	2	Reactome: R-HSA-8949613;Reactome: R-HSA-163210	"Cristae formation";"Formation of ATP by chemiosmotic coupling"
Medex_00066341-RA	4	Reactome: R-HSA-189483;KEGG: 00860+1.14.14.18;Reactome: R-HSA-917937;MetaCyc: PWY-5874	"Heme degradation";"Porphyrin and chlorophyll metabolism";"Iron uptake and transport";"Heme degradation I"
Medex_00034000-RA	3	Reactome: R-HSA-5678520;Reactome: R-HSA-159418;Reactome: R-HSA-193368	"Defective ABCB11 causes progressive familial intrahepatic cholestasis 2 and benign recurrent intrahepatic cholestasis 2";"Recycling of bile acids and salts";"Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol"
Medex_00030488-RA	2	Reactome: R-HSA-3299685;KEGG: 00480+1.11.1.15	"Detoxification of Reactive Oxygen Species";"Glutathione metabolism"
Medex_00047644-RA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
Medex_00042984-RA	6	MetaCyc: PWY-7920;Reactome: R-HSA-975578;MetaCyc: PWY-7426;KEGG: 00513+2.4.1.143;KEGG: 00510+2.4.1.143;Reactome: R-HSA-4793952	"Complex N-linked glycan biosynthesis (plants)";"Reactions specific to the complex N-glycan synthesis pathway";"Complex N-linked glycan biosynthesis (vertebrates)";"Various types of N-glycan biosynthesis";"N-Glycan biosynthesis";"Defective MGAT2 causes MGAT2-CDG (CDG-2a)"
Medex_00027538-RA	1	Reactome: R-HSA-8951664	"Neddylation"
Medex_00091557-RA	9	MetaCyc: PWY-5675;KEGG: 00250+6.3.1.2;MetaCyc: PWY-6549;MetaCyc: PWY-6964;KEGG: 00910+6.3.1.2;MetaCyc: PWY-381;KEGG: 00630+6.3.1.2;MetaCyc: PWY-6963;KEGG: 00220+6.3.1.2	"Nitrate reduction V (assimilatory)";"Alanine, aspartate and glutamate metabolism";"L-glutamine biosynthesis III";"Ammonia assimilation cycle II";"Nitrogen metabolism";"Nitrate reduction II (assimilatory)";"Glyoxylate and dicarboxylate metabolism";"Ammonia assimilation cycle I";"Arginine biosynthesis"
Medex_00014110-RA	2	Reactome: R-HSA-8939243;Reactome: R-HSA-3214858	"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RMTs methylate histone arginines"
Medex_00047864-RA	16	Reactome: R-HSA-72702;Reactome: R-HSA-6791226;Reactome: R-HSA-975956;Reactome: R-HSA-72706;Reactome: R-HSA-72764;Reactome: R-HSA-1799339;Reactome: R-HSA-9633012;Reactome: R-HSA-975957;Reactome: R-HSA-2408557;Reactome: R-HSA-72689;Reactome: R-HSA-72649;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-72695;Reactome: R-HSA-156902;Reactome: R-HSA-192823	"Ribosomal scanning and start codon recognition";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Eukaryotic Translation Termination";"SRP-dependent cotranslational protein targeting to membrane";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Selenocysteine synthesis";"Formation of a pool of free 40S subunits";"Translation initiation complex formation";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Formation of the ternary complex, and subsequently, the 43S complex";"Peptide chain elongation";"Viral mRNA Translation"
Medex_00047940-RA	1	Reactome: R-HSA-140342	"Apoptosis induced DNA fragmentation"
Medex_00002580-RA	2	Reactome: R-HSA-6783984;KEGG: 00260+1.4.4.2	"Glycine degradation";"Glycine, serine and threonine metabolism"
Medex_00022669-RA	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840	"Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation"
Medex_00042472-RA	8	MetaCyc: PWY-7179;Reactome: R-HSA-6798695;MetaCyc: PWY-6609;Reactome: R-HSA-74217;KEGG: 00230+3.5.4.4;MetaCyc: PWY-7179-1;MetaCyc: PWY-6611;Reactome: R-HSA-5683826	"Purine deoxyribonucleosides degradation I";"Neutrophil degranulation";"Adenine and adenosine salvage III";"Purine salvage";"Purine metabolism";"Purine deoxyribonucleosides degradation II";"Adenine and adenosine salvage V";"Surfactant metabolism"
Medex_00085578-RA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
Medex_00043932-RA	1	Reactome: R-HSA-162791	"Attachment of GPI anchor to uPAR"
Medex_00018699-RA	57	Reactome: R-HSA-174084;Reactome: R-HSA-187577;Reactome: R-HSA-5610783;Reactome: R-HSA-8854050;Reactome: R-HSA-1236974;Reactome: R-HSA-5676590;Reactome: R-HSA-5362768;Reactome: R-HSA-69017;Reactome: R-HSA-69601;Reactome: R-HSA-1234176;Reactome: R-HSA-8948751;Reactome: R-HSA-68827;Reactome: R-HSA-9604323;Reactome: R-HSA-5678895;Reactome: R-HSA-350562;Reactome: R-HSA-69481;Reactome: R-HSA-4641257;Reactome: R-HSA-174113;Reactome: R-HSA-2871837;Reactome: R-HSA-8951664;Reactome: R-HSA-174154;Reactome: R-HSA-1169091;Reactome: R-HSA-5607764;Reactome: R-HSA-174184;Reactome: R-HSA-9020702;Reactome: R-HSA-6798695;Reactome: R-HSA-8941858;Reactome: R-HSA-5358346;Reactome: R-HSA-5658442;Reactome: R-HSA-202424;Reactome: R-HSA-983168;Reactome: R-HSA-8939236;Reactome: R-HSA-68949;Reactome: R-HSA-382556;Reactome: R-HSA-211733;Reactome: R-HSA-9010553;Reactome: R-HSA-2467813;Reactome: R-HSA-4641258;Reactome: R-HSA-450408;Reactome: R-HSA-180585;Reactome: R-HSA-5689880;Reactome: R-HSA-5610785;Reactome: R-HSA-4608870;Reactome: R-HSA-5687128;Reactome: R-HSA-5689603;Reactome: R-HSA-5668541;Reactome: R-HSA-75815;Reactome: R-HSA-8939902;Reactome: R-HSA-195253;Reactome: R-HSA-8852276;Reactome: R-HSA-5610780;Reactome: R-HSA-5607761;Reactome: R-HSA-174178;Reactome: R-HSA-5632684;Reactome: R-HSA-180534;Reactome: R-HSA-349425;Reactome: R-HSA-1236978	"Autodegradation of Cdh1 by Cdh1:APC/C";"SCF(Skp2)-mediated degradation of p27/p21";"Degradation of GLI2 by the proteasome";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"ER-Phagosome pathway";"NIK-->noncanonical NF-kB signaling";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"CDK-mediated phosphorylation and removal of Cdc6";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of PTEN stability and activity";"CDT1 association with the CDC6:ORC:origin complex";"Negative regulation of NOTCH4 signaling";"Defective CFTR causes cystic fibrosis";"Regulation of ornithine decarboxylase (ODC)";"G2/M Checkpoints";"Degradation of AXIN";"SCF-beta-TrCP mediated degradation of Emi1";"FCERI mediated NF-kB activation";"Neddylation";"APC/C:Cdc20 mediated degradation of Securin";"Activation of NF-kappaB in B cells";"CLEC7A (Dectin-1) signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Interleukin-1 signaling";"Neutrophil degranulation";"Regulation of RUNX3 expression and activity";"Hedgehog ligand biogenesis";"Regulation of RAS by GAPs";"Downstream TCR signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Orc1 removal from chromatin";"ABC-family proteins mediated transport";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Regulation of expression of SLITs and ROBOs";"Separation of Sister Chromatids";"Degradation of DVL";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Vif-mediated degradation of APOBEC3G";"Ub-specific processing proteases";"GLI3 is processed to GLI3R by the proteasome";"Asymmetric localization of PCP proteins";"MAPK6/MAPK4 signaling";"UCH proteinases";"TNFR2 non-canonical NF-kB pathway";"Ubiquitin-dependent degradation of Cyclin D";"Regulation of RUNX2 expression and activity";"Degradation of beta-catenin by the destruction complex";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Degradation of GLI1 by the proteasome";"Dectin-1 mediated noncanonical NF-kB signaling";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Hedgehog 'on' state";"Vpu mediated degradation of CD4";"Autodegradation of the E3 ubiquitin ligase COP1";"Cross-presentation of soluble exogenous antigens (endosomes)"
Medex_00002106-RA	24	Reactome: R-HSA-418217;Reactome: R-HSA-4086398;Reactome: R-HSA-163359;Reactome: R-HSA-418555;Reactome: R-HSA-381676;Reactome: R-HSA-416482;Reactome: R-HSA-8964315;Reactome: R-HSA-418594;Reactome: R-HSA-416476;Reactome: R-HSA-418597;Reactome: R-HSA-456926;Reactome: R-HSA-8964616;Reactome: R-HSA-392170;Reactome: R-HSA-500657;Reactome: R-HSA-9009391;Reactome: R-HSA-420092;Reactome: R-HSA-418592;Reactome: R-HSA-428930;Reactome: R-HSA-6814122;Reactome: R-HSA-392451;Reactome: R-HSA-202040;Reactome: R-HSA-432040;Reactome: R-HSA-392851;Reactome: R-HSA-400042	"G beta:gamma signalling through PLC beta";"Ca2+ pathway";"Glucagon signaling in metabolic regulation";"G alpha (s) signalling events";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"G alpha (12/13) signalling events";"G beta:gamma signalling through BTK";"G alpha (i) signalling events";"G alpha (q) signalling events";"G alpha (z) signalling events";"Thrombin signalling through proteinase activated receptors (PARs)";"G beta:gamma signalling through CDC42";"ADP signalling through P2Y purinoceptor 12";"Presynaptic function of Kainate receptors";"Extra-nuclear estrogen signaling";"Glucagon-type ligand receptors";"ADP signalling through P2Y purinoceptor 1";"Thromboxane signalling through TP receptor";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"G beta:gamma signalling through PI3Kgamma";"G-protein activation";"Vasopressin regulates renal water homeostasis via Aquaporins";"Prostacyclin signalling through prostacyclin receptor";"Adrenaline,noradrenaline inhibits insulin secretion"
Medex_00030008-RA	3	Reactome: R-HSA-4420097;Reactome: R-HSA-2029482;Reactome: R-HSA-5663213	"VEGFA-VEGFR2 Pathway";"Regulation of actin dynamics for phagocytic cup formation";"RHO GTPases Activate WASPs and WAVEs"
Medex_00022925-RA	1	Reactome: R-HSA-3238698	"WNT ligand biogenesis and trafficking"
Medex_00057563-RA	6	MetaCyc: PWY-6124;MetaCyc: PWY-6123;KEGG: 00230+3.5.4.10+2.1.2.3;Reactome: R-HSA-73817;MetaCyc: PWY-7234;KEGG: 00670+2.1.2.3	"Inosine-5'-phosphate biosynthesis II";"Inosine-5'-phosphate biosynthesis I";"Purine metabolism";"Purine ribonucleoside monophosphate biosynthesis";"Inosine-5'-phosphate biosynthesis III";"One carbon pool by folate"
Medex_00034214-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Medex_00028009-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00023866-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Medex_00009629-RA	1	Reactome: R-HSA-6811436	"COPI-independent Golgi-to-ER retrograde traffic"
Medex_00018370-RA	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
Medex_00005585-RA	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
Medex_00005925-RA	7	Reactome: R-HSA-380972;Reactome: R-HSA-5628897;Reactome: R-HSA-5674400;Reactome: R-HSA-8854214;Reactome: R-HSA-165181;Reactome: R-HSA-198323;Reactome: R-HSA-1632852	"Energy dependent regulation of mTOR by LKB1-AMPK";"TP53 Regulates Metabolic Genes";"Constitutive Signaling by AKT1 E17K in Cancer";"TBC/RABGAPs";"Inhibition of TSC complex formation by PKB";"AKT phosphorylates targets in the cytosol";"Macroautophagy"
Medex_00055521-RA	1	Reactome: R-HSA-425381	"Bicarbonate transporters"
Medex_00009403-RA	3	Reactome: R-HSA-1660662;MetaCyc: PWY-7277;KEGG: 00600+3.1.4.12	"Glycosphingolipid metabolism";"Sphingolipid biosynthesis (mammals)";"Sphingolipid metabolism"
Medex_00058345-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Medex_00001929-RA	14	Reactome: R-HSA-5696400;Reactome: R-HSA-6782135;Reactome: R-HSA-110314;Reactome: R-HSA-174411;Reactome: R-HSA-5655862;Reactome: R-HSA-69091;Reactome: R-HSA-5656169;Reactome: R-HSA-110320;Reactome: R-HSA-5651801;Reactome: R-HSA-5656121;Reactome: R-HSA-6782210;Reactome: R-HSA-110312;Reactome: R-HSA-5685942;Reactome: R-HSA-5696397	"Dual Incision in GG-NER";"Dual incision in TC-NER";"Recognition of DNA damage by PCNA-containing replication complex";"Polymerase switching on the C-strand of the telomere";"Translesion synthesis by POLK";"Polymerase switching";"Termination of translesion DNA synthesis";"Translesion Synthesis by POLH";"PCNA-Dependent Long Patch Base Excision Repair";"Translesion synthesis by POLI";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Translesion synthesis by REV1";"HDR through Homologous Recombination (HRR)";"Gap-filling DNA repair synthesis and ligation in GG-NER"
Medex_00056786-RA	1	KEGG: 00970+6.3.5.7	"Aminoacyl-tRNA biosynthesis"
Medex_00013181-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Medex_00052162-RA	22	Reactome: R-HSA-141444;Reactome: R-HSA-4641262;Reactome: R-HSA-432142;Reactome: R-HSA-195253;Reactome: R-HSA-389513;Reactome: R-HSA-5673000;Reactome: R-HSA-6811558;Reactome: R-HSA-5467348;Reactome: R-HSA-5358751;Reactome: R-HSA-5358749;Reactome: R-HSA-5358747;Reactome: R-HSA-5675221;Reactome: R-HSA-5339716;Reactome: R-HSA-2500257;Reactome: R-HSA-5358752;Reactome: R-HSA-5663220;Reactome: R-HSA-196299;Reactome: R-HSA-68877;Reactome: R-HSA-9648025;Reactome: R-HSA-5467340;Reactome: R-HSA-5467337;Reactome: R-HSA-2467813	"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"Platelet sensitization by LDL";"Degradation of beta-catenin by the destruction complex";"CTLA4 inhibitory signaling";"RAF activation";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"Truncations of AMER1 destabilize the destruction complex";"S45 mutants of beta-catenin aren't phosphorylated";"S37 mutants of beta-catenin aren't phosphorylated";"S33 mutants of beta-catenin aren't phosphorylated";"Negative regulation of MAPK pathway";"Misspliced GSK3beta mutants stabilize beta-catenin";"Resolution of Sister Chromatid Cohesion";"T41 mutants of beta-catenin aren't phosphorylated";"RHO GTPases Activate Formins";"Beta-catenin phosphorylation cascade";"Mitotic Prometaphase";"EML4 and NUDC in mitotic spindle formation";"AXIN missense mutants destabilize the destruction complex";"APC truncation mutants have impaired AXIN binding";"Separation of Sister Chromatids"
Medex_00058904-RA	17	MetaCyc: PWY-6644;MetaCyc: PWY-7179;Reactome: R-HSA-6798695;KEGG: 00230+2.4.2.1;Reactome: R-HSA-74259;MetaCyc: PWY-4202;MetaCyc: PWY-6609;MetaCyc: PWY-5695;MetaCyc: PWY-6627;MetaCyc: PWY-6620;MetaCyc: PWY-7179-1;KEGG: 00760+2.4.2.1;MetaCyc: PWY-6611;Reactome: R-HSA-74217;MetaCyc: PWY-6608;MetaCyc: PWY-5532;KEGG: 00240+2.4.2.1	"Fluoroacetate and fluorothreonine biosynthesis";"Purine deoxyribonucleosides degradation I";"Neutrophil degranulation";"Purine metabolism";"Purine catabolism";"Arsenate detoxification I (mammalian)";"Adenine and adenosine salvage III";"Inosine 5'-phosphate degradation";"Salinosporamide A biosynthesis";"Guanine and guanosine salvage";"Purine deoxyribonucleosides degradation II";"Nicotinate and nicotinamide metabolism";"Adenine and adenosine salvage V";"Purine salvage";"Guanosine nucleotides degradation III";"Nucleoside and nucleotide degradation (archaea)";"Pyrimidine metabolism"
Medex_00016521-RA	7	Reactome: R-HSA-176187;Reactome: R-HSA-68689;Reactome: R-HSA-68962;Reactome: R-HSA-69205;Reactome: R-HSA-68867;Reactome: R-HSA-68949;Reactome: R-HSA-68827	"Activation of ATR in response to replication stress";"CDC6 association with the ORC:origin complex";"Activation of the pre-replicative complex";"G1/S-Specific Transcription";"Assembly of the pre-replicative complex";"Orc1 removal from chromatin";"CDT1 association with the CDC6:ORC:origin complex"
Medex_00062963-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00014034-RA	33	Reactome: R-HSA-165054;Reactome: R-HSA-180746;Reactome: R-HSA-3371453;Reactome: R-HSA-4615885;Reactome: R-HSA-168276;Reactome: R-HSA-5578749;Reactome: R-HSA-2500257;Reactome: R-HSA-3301854;Reactome: R-HSA-180910;Reactome: R-HSA-4570464;Reactome: R-HSA-4085377;Reactome: R-HSA-9609690;Reactome: R-HSA-9610379;Reactome: R-HSA-5619107;Reactome: R-HSA-159236;Reactome: R-HSA-3108214;Reactome: R-HSA-6784531;Reactome: R-HSA-1169408;Reactome: R-HSA-2467813;Reactome: R-HSA-168333;Reactome: R-HSA-159227;Reactome: R-HSA-159231;Reactome: R-HSA-9648025;Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-159230;Reactome: R-HSA-3232142;Reactome: R-HSA-168271;Reactome: R-HSA-170822;Reactome: R-HSA-4551638;Reactome: R-HSA-168325;Reactome: R-HSA-191859;Reactome: R-HSA-141444	"Rev-mediated nuclear export of HIV RNA";"Nuclear import of Rev protein";"Regulation of HSF1-mediated heat shock response";"SUMOylation of DNA replication proteins";"NS1 Mediated Effects on Host Pathways";"Transcriptional regulation by small RNAs";"Resolution of Sister Chromatid Cohesion";"Nuclear Pore Complex (NPC) Disassembly";"Vpr-mediated nuclear import of PICs";"SUMOylation of RNA binding proteins";"SUMOylation of SUMOylation proteins";"HCMV Early Events";"HCMV Late Events";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"SUMOylation of DNA damage response and repair proteins";"tRNA processing in the nucleus";"ISG15 antiviral mechanism";"Separation of Sister Chromatids";"NEP/NS2 Interacts with the Cellular Export Machinery";"Transport of the SLBP independent Mature mRNA";"Transport of Mature mRNA Derived from an Intronless Transcript";"EML4 and NUDC in mitotic spindle formation";"Mitotic Prometaphase";"RHO GTPases Activate Formins";"Transport of the SLBP Dependant Mature mRNA";"SUMOylation of ubiquitinylation proteins";"Transport of Ribonucleoproteins into the Host Nucleus";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"SUMOylation of chromatin organization proteins";"Viral Messenger RNA Synthesis";"snRNP Assembly";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"
Medex_00017295-RA	6	MetaCyc: PWY-6807;KEGG: 00600+3.2.1.23;KEGG: 00511+3.2.1.23;KEGG: 00604+3.2.1.23;KEGG: 00052+3.2.1.23;KEGG: 00531+3.2.1.23	"Xyloglucan degradation II (exoglucanase)";"Sphingolipid metabolism";"Other glycan degradation";"Glycosphingolipid biosynthesis - ganglio series";"Galactose metabolism";"Glycosaminoglycan degradation"
Medex_00036356-RA	1	Reactome: R-HSA-428359	"Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA"
Medex_00020593-RA	22	Reactome: R-HSA-5673000;Reactome: R-HSA-6811558;Reactome: R-HSA-5358749;Reactome: R-HSA-5467348;Reactome: R-HSA-5358751;Reactome: R-HSA-432142;Reactome: R-HSA-195253;Reactome: R-HSA-389513;Reactome: R-HSA-141444;Reactome: R-HSA-4641262;Reactome: R-HSA-5467340;Reactome: R-HSA-5467337;Reactome: R-HSA-2467813;Reactome: R-HSA-68877;Reactome: R-HSA-9648025;Reactome: R-HSA-5358752;Reactome: R-HSA-196299;Reactome: R-HSA-5663220;Reactome: R-HSA-5358747;Reactome: R-HSA-5339716;Reactome: R-HSA-5675221;Reactome: R-HSA-2500257	"RAF activation";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"S37 mutants of beta-catenin aren't phosphorylated";"Truncations of AMER1 destabilize the destruction complex";"S45 mutants of beta-catenin aren't phosphorylated";"Platelet sensitization by LDL";"Degradation of beta-catenin by the destruction complex";"CTLA4 inhibitory signaling";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"AXIN missense mutants destabilize the destruction complex";"APC truncation mutants have impaired AXIN binding";"Separation of Sister Chromatids";"Mitotic Prometaphase";"EML4 and NUDC in mitotic spindle formation";"T41 mutants of beta-catenin aren't phosphorylated";"Beta-catenin phosphorylation cascade";"RHO GTPases Activate Formins";"S33 mutants of beta-catenin aren't phosphorylated";"Misspliced GSK3beta mutants stabilize beta-catenin";"Negative regulation of MAPK pathway";"Resolution of Sister Chromatid Cohesion"
Medex_00053986-RA	1	Reactome: R-HSA-9633012	"Response of EIF2AK4 (GCN2) to amino acid deficiency"
Medex_00089382-RA	6	KEGG: 00030+3.1.1.17;MetaCyc: PWY-5530;KEGG: 00930+3.1.1.17;KEGG: 00053+3.1.1.17;MetaCyc: PWY-7165;MetaCyc: PWY-2221	"Pentose phosphate pathway";"Sorbitol biosynthesis II";"Caprolactam degradation";"Ascorbate and aldarate metabolism";"L-ascorbate biosynthesis VI (engineered pathway)";"Entner-Doudoroff pathway III (semi-phosphorylative)"
Medex_00034758-RA	3	Reactome: R-HSA-674695;Reactome: R-HSA-75955;Reactome: R-HSA-112382	"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Elongation";"Formation of RNA Pol II elongation complex"
Medex_00016228-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Medex_00084058-RA	1	Reactome: R-HSA-203641	"NOSTRIN mediated eNOS trafficking"
Medex_00044843-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Medex_00004267-RA	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276	"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination"
Medex_00059313-RA	5	KEGG: 00720+4.2.1.3;KEGG: 00290+4.2.1.33;Reactome: R-HSA-917937;KEGG: 00020+4.2.1.3;KEGG: 00630+4.2.1.3	"Carbon fixation pathways in prokaryotes";"Valine, leucine and isoleucine biosynthesis";"Iron uptake and transport";"Citrate cycle (TCA cycle)";"Glyoxylate and dicarboxylate metabolism"
Medex_00085196-RA	5	Reactome: R-HSA-211981;Reactome: R-HSA-1989781;Reactome: R-HSA-8937144;Reactome: R-HSA-211976;Reactome: R-HSA-211945	"Xenobiotics";"PPARA activates gene expression";"Aryl hydrocarbon receptor signalling";"Endogenous sterols";"Phase I - Functionalization of compounds"
Medex_00023729-RA	1	Reactome: R-HSA-2022377	"Metabolism of Angiotensinogen to Angiotensins"
Medex_00015109-RA	5	Reactome: R-HSA-2132295;Reactome: R-HSA-6798695;Reactome: R-HSA-4341670;Reactome: R-HSA-1660662;Reactome: R-HSA-4085001	"MHC class II antigen presentation";"Neutrophil degranulation";"Defective NEU1 causes sialidosis";"Glycosphingolipid metabolism";"Sialic acid metabolism"
Medex_00072709-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00078680-RA	2	Reactome: R-HSA-3238698;Reactome: R-HSA-373080	"WNT ligand biogenesis and trafficking";"Class B/2 (Secretin family receptors)"
Medex_00010167-RA	1	Reactome: R-HSA-5632928	"Defective Mismatch Repair Associated With MSH2"
Medex_00052939-RA	27	Reactome: R-HSA-3108214;Reactome: R-HSA-6784531;Reactome: R-HSA-168325;Reactome: R-HSA-191859;Reactome: R-HSA-159236;Reactome: R-HSA-9610379;Reactome: R-HSA-5619107;Reactome: R-HSA-4551638;Reactome: R-HSA-9609690;Reactome: R-HSA-4085377;Reactome: R-HSA-170822;Reactome: R-HSA-4570464;Reactome: R-HSA-168271;Reactome: R-HSA-180910;Reactome: R-HSA-3232142;Reactome: R-HSA-3301854;Reactome: R-HSA-168276;Reactome: R-HSA-5578749;Reactome: R-HSA-4615885;Reactome: R-HSA-159230;Reactome: R-HSA-3371453;Reactome: R-HSA-159231;Reactome: R-HSA-180746;Reactome: R-HSA-159227;Reactome: R-HSA-1169408;Reactome: R-HSA-168333;Reactome: R-HSA-165054	"SUMOylation of DNA damage response and repair proteins";"tRNA processing in the nucleus";"Viral Messenger RNA Synthesis";"snRNP Assembly";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"HCMV Late Events";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"SUMOylation of chromatin organization proteins";"HCMV Early Events";"SUMOylation of SUMOylation proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"SUMOylation of RNA binding proteins";"Transport of Ribonucleoproteins into the Host Nucleus";"Vpr-mediated nuclear import of PICs";"SUMOylation of ubiquitinylation proteins";"Nuclear Pore Complex (NPC) Disassembly";"NS1 Mediated Effects on Host Pathways";"Transcriptional regulation by small RNAs";"SUMOylation of DNA replication proteins";"Transport of the SLBP Dependant Mature mRNA";"Regulation of HSF1-mediated heat shock response";"Transport of Mature mRNA Derived from an Intronless Transcript";"Nuclear import of Rev protein";"Transport of the SLBP independent Mature mRNA";"ISG15 antiviral mechanism";"NEP/NS2 Interacts with the Cellular Export Machinery";"Rev-mediated nuclear export of HIV RNA"
Medex_00069631-RA	8	Reactome: R-HSA-2500257;Reactome: R-HSA-141444;Reactome: R-HSA-4615885;Reactome: R-HSA-5663220;Reactome: R-HSA-9648025;Reactome: R-HSA-68877;Reactome: R-HSA-2467813;Reactome: R-HSA-165054	"Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"SUMOylation of DNA replication proteins";"RHO GTPases Activate Formins";"EML4 and NUDC in mitotic spindle formation";"Mitotic Prometaphase";"Separation of Sister Chromatids";"Rev-mediated nuclear export of HIV RNA"
Medex_00045234-RA	2	Reactome: R-HSA-429947;Reactome: R-HSA-6804115	"Deadenylation of mRNA";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"
Medex_00002624-RA	2	KEGG: 00511+3.2.1.24;Reactome: R-HSA-8853383	"Other glycan degradation";"Lysosomal oligosaccharide catabolism"
Medex_00096309-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00019115-RA	2	Reactome: R-HSA-6784531;Reactome: R-HSA-6791226	"tRNA processing in the nucleus";"Major pathway of rRNA processing in the nucleolus and cytosol"
Medex_00077848-RA	13	Reactome: R-HSA-192823;Reactome: R-HSA-975957;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-156902;Reactome: R-HSA-1799339;Reactome: R-HSA-72689;Reactome: R-HSA-72764;Reactome: R-HSA-975956;Reactome: R-HSA-72706;Reactome: R-HSA-6791226;Reactome: R-HSA-2408557	"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Peptide chain elongation";"SRP-dependent cotranslational protein targeting to membrane";"Formation of a pool of free 40S subunits";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Major pathway of rRNA processing in the nucleolus and cytosol";"Selenocysteine synthesis"
Medex_00019652-RA	4	Reactome: R-HSA-8866654;Reactome: R-HSA-75955;Reactome: R-HSA-112382;Reactome: R-HSA-674695	"E3 ubiquitin ligases ubiquitinate target proteins";"RNA Polymerase II Transcription Elongation";"Formation of RNA Pol II elongation complex";"RNA Polymerase II Pre-transcription Events"
Medex_00057899-RA	1	Reactome: R-HSA-5620922	"BBSome-mediated cargo-targeting to cilium"
Medex_00077715-RA	1	Reactome: R-HSA-216083	"Integrin cell surface interactions"
Medex_00074258-RA	2	Reactome: R-HSA-6807878;Reactome: R-HSA-6811434	"COPI-mediated anterograde transport";"COPI-dependent Golgi-to-ER retrograde traffic"
Medex_00001438-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00063559-RA	4	KEGG: 00270+1.13.11.20;KEGG: 00430+1.13.11.20;MetaCyc: PWY-5331;Reactome: R-HSA-1614558	"Cysteine and methionine metabolism";"Taurine and hypotaurine metabolism";"Taurine biosynthesis I";"Degradation of cysteine and homocysteine"
Medex_00066279-RA	1	Reactome: R-HSA-6811436	"COPI-independent Golgi-to-ER retrograde traffic"
Medex_00025312-RA	15	Reactome: R-HSA-8863795;Reactome: R-HSA-9665250;Reactome: R-HSA-9665233;Reactome: R-HSA-9665247;Reactome: R-HSA-5637810;Reactome: R-HSA-9664565;Reactome: R-HSA-1227986;Reactome: R-HSA-9665245;Reactome: R-HSA-9665246;Reactome: R-HSA-9634285;Reactome: R-HSA-9652282;Reactome: R-HSA-1236382;Reactome: R-HSA-9665244;Reactome: R-HSA-9665249;Reactome: R-HSA-9665251	"Downregulation of ERBB2 signaling";"Resistance of ERBB2 KD mutants to AEE788";"Resistance of ERBB2 KD mutants to trastuzumab";"Resistance of ERBB2 KD mutants to osimertinib";"Constitutive Signaling by EGFRvIII";"Signaling by ERBB2 KD Mutants";"Signaling by ERBB2";"Resistance of ERBB2 KD mutants to tesevatinib";"Resistance of ERBB2 KD mutants to neratinib";"Constitutive Signaling by Overexpressed ERBB2";"Drug-mediated inhibition of ERBB2 signaling";"Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants";"Resistance of ERBB2 KD mutants to sapitinib";"Resistance of ERBB2 KD mutants to afatinib";"Resistance of ERBB2 KD mutants to lapatinib"
Medex_00022882-RA	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
Medex_00072679-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Medex_00027350-RA	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
Medex_00008414-RA	1	Reactome: R-HSA-83936	"Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"
Medex_00070227-RA	1	Reactome: R-HSA-196843	"Vitamin B2 (riboflavin) metabolism"
Medex_00062468-RA	1	Reactome: R-HSA-204005	"COPII-mediated vesicle transport"
Medex_00023317-RA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00095948-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00086969-RA	6	MetaCyc: PWY-6807;KEGG: 00600+3.2.1.23;KEGG: 00511+3.2.1.23;KEGG: 00604+3.2.1.23;KEGG: 00531+3.2.1.23;KEGG: 00052+3.2.1.23	"Xyloglucan degradation II (exoglucanase)";"Sphingolipid metabolism";"Other glycan degradation";"Glycosphingolipid biosynthesis - ganglio series";"Glycosaminoglycan degradation";"Galactose metabolism"
Medex_00005946-RA	1	Reactome: R-HSA-6802952	"Signaling by BRAF and RAF fusions"
Medex_00088688-RA	3	Reactome: R-HSA-2142691;Reactome: R-HSA-5423646;MetaCyc: PWY-7533	"Synthesis of Leukotrienes (LT) and Eoxins (EX)";"Aflatoxin activation and detoxification";"Gliotoxin biosynthesis"
Medex_00054175-RA	3	Reactome: R-HSA-8963684;KEGG: 00643+1.13.11.5;KEGG: 00350+1.13.11.5	"Tyrosine catabolism";"Styrene degradation";"Tyrosine metabolism"
Medex_00089199-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Medex_00024778-RA	22	KEGG: 00010+5.3.1.9;MetaCyc: PWY-3801;MetaCyc: PWY-621;MetaCyc: PWY-6992;MetaCyc: PWY-622;KEGG: 00500+5.3.1.9;MetaCyc: PWY-6142;MetaCyc: PWY-5514;Reactome: R-HSA-5628897;MetaCyc: PWY-8013;Reactome: R-HSA-6798695;Reactome: R-HSA-70171;Reactome: R-HSA-70263;MetaCyc: PWY-5054;MetaCyc: PWY-5659;MetaCyc: PWY-7347;MetaCyc: PWY-7385;KEGG: 00520+5.3.1.9;MetaCyc: PWY-6981;KEGG: 00030+5.3.1.9;MetaCyc: PWY-7238;MetaCyc: PWY-5384	"Glycolysis / Gluconeogenesis";"Sucrose degradation II (sucrose synthase)";"Sucrose degradation III (sucrose invertase)";"1,5-anhydrofructose degradation";"Starch biosynthesis";"Starch and sucrose metabolism";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"UDP-N-acetyl-D-galactosamine biosynthesis II";"TP53 Regulates Metabolic Genes";"UDP-N-acetyl-D-galactosamine biosynthesis III";"Neutrophil degranulation";"Glycolysis";"Gluconeogenesis";"D-sorbitol biosynthesis I";"GDP-mannose biosynthesis";"Sucrose biosynthesis III";"1,3-propanediol biosynthesis (engineered)";"Amino sugar and nucleotide sugar metabolism";"Chitin biosynthesis";"Pentose phosphate pathway";"Sucrose biosynthesis II";"Sucrose degradation IV (sucrose phosphorylase)"
Medex_00018668-RA	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
Medex_00004769-RA	3	Reactome: R-HSA-204005;Reactome: R-HSA-5694530;Reactome: R-HSA-948021	"COPII-mediated vesicle transport";"Cargo concentration in the ER";"Transport to the Golgi and subsequent modification"
Medex_00014599-RA	6	KEGG: 00531+3.2.1.23;KEGG: 00052+3.2.1.23;KEGG: 00604+3.2.1.23;KEGG: 00600+3.2.1.23;KEGG: 00511+3.2.1.23;MetaCyc: PWY-6807	"Glycosaminoglycan degradation";"Galactose metabolism";"Glycosphingolipid biosynthesis - ganglio series";"Sphingolipid metabolism";"Other glycan degradation";"Xyloglucan degradation II (exoglucanase)"
Medex_00065243-RA	2	Reactome: R-HSA-163841;KEGG: 00900+2.1.1.100	"Gamma carboxylation, hypusine formation and arylsulfatase activation";"Terpenoid backbone biosynthesis"
Medex_00083221-RA	2	MetaCyc: PWY-7511;Reactome: R-HSA-5689880	"Protein ubiquitination";"Ub-specific processing proteases"
Medex_00022558-RA	1	Reactome: R-HSA-1632852	"Macroautophagy"
Medex_00082857-RA	2	KEGG: 00480+1.11.1.15;Reactome: R-HSA-3299685	"Glutathione metabolism";"Detoxification of Reactive Oxygen Species"
Medex_00090376-RA	5	Reactome: R-HSA-917977;Reactome: R-HSA-1222556;Reactome: R-HSA-9639288;Reactome: R-HSA-77387;Reactome: R-HSA-983712	"Transferrin endocytosis and recycling";"ROS and RNS production in phagocytes";"Amino acids regulate mTORC1";"Insulin receptor recycling";"Ion channel transport"
Medex_00019128-RA	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
Medex_00019251-RA	1	Reactome: R-HSA-2467813	"Separation of Sister Chromatids"
Medex_00000522-RA	16	Reactome: R-HSA-1236974;Reactome: R-HSA-1257604;Reactome: R-HSA-5602498;Reactome: R-HSA-166058;Reactome: R-HSA-975138;Reactome: R-HSA-975871;Reactome: R-HSA-9020702;Reactome: R-HSA-209543;Reactome: R-HSA-3134963;Reactome: R-HSA-5603037;Reactome: R-HSA-975110;Reactome: R-HSA-6811558;Reactome: R-HSA-1810476;Reactome: R-HSA-5603041;Reactome: R-HSA-5602680;Reactome: R-HSA-975155	"ER-Phagosome pathway";"PIP3 activates AKT signaling";"MyD88 deficiency (TLR2/4)";"MyD88:MAL(TIRAP) cascade initiated on plasma membrane";"TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation";"MyD88 cascade initiated on plasma membrane";"Interleukin-1 signaling";"p75NTR recruits signalling complexes";"DEx/H-box helicases activate type I IFN and inflammatory cytokines production";"IRAK4 deficiency (TLR5)";"TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"RIP-mediated NFkB activation via ZBP1";"IRAK4 deficiency (TLR2/4)";"MyD88 deficiency (TLR5)";"MyD88 dependent cascade initiated on endosome"
Medex_00089803-RA	1	Reactome: R-HSA-6798163	"Choline catabolism"
Medex_00045573-RA	1	Reactome: R-HSA-8849932	"Synaptic adhesion-like molecules"
Medex_00046176-RA	2	Reactome: R-HSA-611105;Reactome: R-HSA-1268020	"Respiratory electron transport";"Mitochondrial protein import"
Medex_00012190-RA	1	Reactome: R-HSA-376172	"DSCAM interactions"
Medex_00041670-RA	2	Reactome: R-HSA-390471;Reactome: R-HSA-1660662	"Association of TriC/CCT with target proteins during biosynthesis";"Glycosphingolipid metabolism"
Medex_00087389-RA	3	Reactome: R-HSA-193368;Reactome: R-HSA-159418;Reactome: R-HSA-5678520	"Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol";"Recycling of bile acids and salts";"Defective ABCB11 causes progressive familial intrahepatic cholestasis 2 and benign recurrent intrahepatic cholestasis 2"
Medex_00100689-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Medex_00003792-RA	1	Reactome: R-HSA-1445148	"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
Medex_00041525-RA	5	Reactome: R-HSA-6798695;Reactome: R-HSA-2132295;Reactome: R-HSA-4085001;Reactome: R-HSA-1660662;Reactome: R-HSA-4341670	"Neutrophil degranulation";"MHC class II antigen presentation";"Sialic acid metabolism";"Glycosphingolipid metabolism";"Defective NEU1 causes sialidosis"
Medex_00064206-RA	1	KEGG: 00270+2.1.1.37	"Cysteine and methionine metabolism"
Medex_00075353-RA	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
Medex_00010165-RA	3	Reactome: R-HSA-5632968;Reactome: R-HSA-5358565;Reactome: R-HSA-5632928	"Defective Mismatch Repair Associated With MSH6";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"Defective Mismatch Repair Associated With MSH2"
Medex_00038680-RA	3	Reactome: R-HSA-159740;KEGG: 00130+4.1.1.90;MetaCyc: PWY-7999	"Gamma-carboxylation of protein precursors";"Ubiquinone and other terpenoid-quinone biosynthesis";"Vitamin K-epoxide cycle"
Medex_00092842-RA	2	Reactome: R-HSA-168276;Reactome: R-HSA-1169408	"NS1 Mediated Effects on Host Pathways";"ISG15 antiviral mechanism"
Medex_00030479-RA	1	Reactome: R-HSA-400253	"Circadian Clock"
Medex_00092765-RA	1	Reactome: R-HSA-1296061	"HCN channels"
Medex_00049196-RA	15	Reactome: R-HSA-167238;Reactome: R-HSA-6796648;Reactome: R-HSA-75955;Reactome: R-HSA-9018519;Reactome: R-HSA-112382;Reactome: R-HSA-167246;Reactome: R-HSA-2173796;Reactome: R-HSA-167200;Reactome: R-HSA-167290;Reactome: R-HSA-167152;Reactome: R-HSA-6807505;Reactome: R-HSA-674695;Reactome: R-HSA-167287;Reactome: R-HSA-176034;Reactome: R-HSA-167243	"Pausing and recovery of Tat-mediated HIV elongation";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Transcription Elongation";"Estrogen-dependent gene expression";"Formation of RNA Pol II elongation complex";"Tat-mediated elongation of the HIV-1 transcript";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Pausing and recovery of HIV elongation";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA polymerase II transcribes snRNA genes";"RNA Polymerase II Pre-transcription Events";"HIV elongation arrest and recovery";"Interactions of Tat with host cellular proteins";"Tat-mediated HIV elongation arrest and recovery"
Medex_00038831-RA	1	KEGG: 00290+4.2.1.33	"Valine, leucine and isoleucine biosynthesis"
Medex_00097808-RA	1	MetaCyc: PWY-7379	"Mrna capping II"
Medex_00016779-RA	1	Reactome: R-HSA-189451	"Heme biosynthesis"
Medex_00095009-RA	5	Reactome: R-HSA-165181;Reactome: R-HSA-1632852;Reactome: R-HSA-380972;Reactome: R-HSA-8854214;Reactome: R-HSA-5628897	"Inhibition of TSC complex formation by PKB";"Macroautophagy";"Energy dependent regulation of mTOR by LKB1-AMPK";"TBC/RABGAPs";"TP53 Regulates Metabolic Genes"
Medex_00046164-RA	11	MetaCyc: PWY-6963;KEGG: 00220+6.3.1.2;Reactome: R-HSA-210455;MetaCyc: PWY-5675;KEGG: 00250+6.3.1.2;Reactome: R-HSA-8964539;KEGG: 00910+6.3.1.2;MetaCyc: PWY-6549;MetaCyc: PWY-6964;KEGG: 00630+6.3.1.2;MetaCyc: PWY-381	"Ammonia assimilation cycle I";"Arginine biosynthesis";"Astrocytic Glutamate-Glutamine Uptake And Metabolism";"Nitrate reduction V (assimilatory)";"Alanine, aspartate and glutamate metabolism";"Glutamate and glutamine metabolism";"Nitrogen metabolism";"L-glutamine biosynthesis III";"Ammonia assimilation cycle II";"Glyoxylate and dicarboxylate metabolism";"Nitrate reduction II (assimilatory)"
Medex_00040699-RA	1	Reactome: R-HSA-5624958	"ARL13B-mediated ciliary trafficking of INPP5E"
Medex_00017464-RA	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
Medex_00078869-RA	1	Reactome: R-HSA-71288	"Creatine metabolism"
Medex_00035611-RA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
Medex_00072698-RA	3	Reactome: R-HSA-110331;Reactome: R-HSA-110357;Reactome: R-HSA-110330	"Cleavage of the damaged purine";"Displacement of DNA glycosylase by APEX1";"Recognition and association of DNA glycosylase with site containing an affected purine"
Medex_00000496-RA	1	Reactome: R-HSA-211981	"Xenobiotics"
Medex_00007629-RA	11	Reactome: R-HSA-210744;Reactome: R-HSA-350054;Reactome: R-HSA-8941856;Reactome: R-HSA-2644606;Reactome: R-HSA-72163;Reactome: R-HSA-2122947;Reactome: R-HSA-9013695;Reactome: R-HSA-2173796;Reactome: R-HSA-9013508;Reactome: R-HSA-2894862;Reactome: R-HSA-1912408	"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"Notch-HLH transcription pathway";"RUNX3 regulates NOTCH signaling";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"mRNA Splicing - Major Pathway";"NOTCH1 Intracellular Domain Regulates Transcription";"NOTCH4 Intracellular Domain Regulates Transcription";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"NOTCH3 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Pre-NOTCH Transcription and Translation"
Medex_00025033-RA	2	Reactome: R-HSA-190873;Reactome: R-HSA-399719	"Gap junction degradation";"Trafficking of AMPA receptors"
Medex_00022494-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Medex_00087727-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00009772-RA	2	Reactome: R-HSA-6807878;Reactome: R-HSA-6811434	"COPI-mediated anterograde transport";"COPI-dependent Golgi-to-ER retrograde traffic"
Medex_00009149-RA	57	Reactome: R-HSA-1169091;Reactome: R-HSA-174154;Reactome: R-HSA-174184;Reactome: R-HSA-5607764;Reactome: R-HSA-8951664;Reactome: R-HSA-2871837;Reactome: R-HSA-5678895;Reactome: R-HSA-69481;Reactome: R-HSA-350562;Reactome: R-HSA-174113;Reactome: R-HSA-4641257;Reactome: R-HSA-1234176;Reactome: R-HSA-69601;Reactome: R-HSA-69017;Reactome: R-HSA-5362768;Reactome: R-HSA-5676590;Reactome: R-HSA-9604323;Reactome: R-HSA-8948751;Reactome: R-HSA-68827;Reactome: R-HSA-5610783;Reactome: R-HSA-1236974;Reactome: R-HSA-8854050;Reactome: R-HSA-187577;Reactome: R-HSA-174084;Reactome: R-HSA-5632684;Reactome: R-HSA-349425;Reactome: R-HSA-1236978;Reactome: R-HSA-180534;Reactome: R-HSA-5607761;Reactome: R-HSA-8852276;Reactome: R-HSA-5610780;Reactome: R-HSA-174178;Reactome: R-HSA-8939902;Reactome: R-HSA-75815;Reactome: R-HSA-195253;Reactome: R-HSA-5610785;Reactome: R-HSA-5689880;Reactome: R-HSA-5687128;Reactome: R-HSA-5668541;Reactome: R-HSA-5689603;Reactome: R-HSA-4608870;Reactome: R-HSA-4641258;Reactome: R-HSA-2467813;Reactome: R-HSA-180585;Reactome: R-HSA-450408;Reactome: R-HSA-9010553;Reactome: R-HSA-8939236;Reactome: R-HSA-382556;Reactome: R-HSA-68949;Reactome: R-HSA-211733;Reactome: R-HSA-5658442;Reactome: R-HSA-5358346;Reactome: R-HSA-8941858;Reactome: R-HSA-983168;Reactome: R-HSA-202424;Reactome: R-HSA-9020702;Reactome: R-HSA-6798695	"Activation of NF-kappaB in B cells";"APC/C:Cdc20 mediated degradation of Securin";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"CLEC7A (Dectin-1) signaling";"Neddylation";"FCERI mediated NF-kB activation";"Defective CFTR causes cystic fibrosis";"G2/M Checkpoints";"Regulation of ornithine decarboxylase (ODC)";"SCF-beta-TrCP mediated degradation of Emi1";"Degradation of AXIN";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"CDK-mediated phosphorylation and removal of Cdc6";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"NIK-->noncanonical NF-kB signaling";"Negative regulation of NOTCH4 signaling";"Regulation of PTEN stability and activity";"CDT1 association with the CDC6:ORC:origin complex";"Degradation of GLI2 by the proteasome";"ER-Phagosome pathway";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"SCF(Skp2)-mediated degradation of p27/p21";"Autodegradation of Cdh1 by Cdh1:APC/C";"Hedgehog 'on' state";"Autodegradation of the E3 ubiquitin ligase COP1";"Cross-presentation of soluble exogenous antigens (endosomes)";"Vpu mediated degradation of CD4";"Dectin-1 mediated noncanonical NF-kB signaling";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Degradation of GLI1 by the proteasome";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Regulation of RUNX2 expression and activity";"Ubiquitin-dependent degradation of Cyclin D";"Degradation of beta-catenin by the destruction complex";"GLI3 is processed to GLI3R by the proteasome";"Ub-specific processing proteases";"MAPK6/MAPK4 signaling";"TNFR2 non-canonical NF-kB pathway";"UCH proteinases";"Asymmetric localization of PCP proteins";"Degradation of DVL";"Separation of Sister Chromatids";"Vif-mediated degradation of APOBEC3G";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Regulation of expression of SLITs and ROBOs";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"ABC-family proteins mediated transport";"Orc1 removal from chromatin";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Regulation of RAS by GAPs";"Hedgehog ligand biogenesis";"Regulation of RUNX3 expression and activity";"Antigen processing: Ubiquitination & Proteasome degradation";"Downstream TCR signaling";"Interleukin-1 signaling";"Neutrophil degranulation"
Medex_00058739-RA	56	Reactome: R-HSA-9020702;Reactome: R-HSA-202424;Reactome: R-HSA-983168;Reactome: R-HSA-5358346;Reactome: R-HSA-8941858;Reactome: R-HSA-5658442;Reactome: R-HSA-8939236;Reactome: R-HSA-211733;Reactome: R-HSA-68949;Reactome: R-HSA-382556;Reactome: R-HSA-9010553;Reactome: R-HSA-450408;Reactome: R-HSA-180585;Reactome: R-HSA-2467813;Reactome: R-HSA-4641258;Reactome: R-HSA-4608870;Reactome: R-HSA-5668541;Reactome: R-HSA-5687128;Reactome: R-HSA-5689603;Reactome: R-HSA-5610785;Reactome: R-HSA-5689880;Reactome: R-HSA-195253;Reactome: R-HSA-75815;Reactome: R-HSA-8939902;Reactome: R-HSA-174178;Reactome: R-HSA-5610780;Reactome: R-HSA-8852276;Reactome: R-HSA-5607761;Reactome: R-HSA-180534;Reactome: R-HSA-349425;Reactome: R-HSA-1236978;Reactome: R-HSA-5632684;Reactome: R-HSA-174084;Reactome: R-HSA-187577;Reactome: R-HSA-8854050;Reactome: R-HSA-1236974;Reactome: R-HSA-5610783;Reactome: R-HSA-9604323;Reactome: R-HSA-68827;Reactome: R-HSA-8948751;Reactome: R-HSA-5676590;Reactome: R-HSA-69601;Reactome: R-HSA-5362768;Reactome: R-HSA-1234176;Reactome: R-HSA-69017;Reactome: R-HSA-4641257;Reactome: R-HSA-174113;Reactome: R-HSA-69481;Reactome: R-HSA-350562;Reactome: R-HSA-5678895;Reactome: R-HSA-2871837;Reactome: R-HSA-8951664;Reactome: R-HSA-5607764;Reactome: R-HSA-174184;Reactome: R-HSA-174154;Reactome: R-HSA-1169091	"Interleukin-1 signaling";"Downstream TCR signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Hedgehog ligand biogenesis";"Regulation of RUNX3 expression and activity";"Regulation of RAS by GAPs";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Orc1 removal from chromatin";"ABC-family proteins mediated transport";"Regulation of expression of SLITs and ROBOs";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Vif-mediated degradation of APOBEC3G";"Separation of Sister Chromatids";"Degradation of DVL";"Asymmetric localization of PCP proteins";"TNFR2 non-canonical NF-kB pathway";"MAPK6/MAPK4 signaling";"UCH proteinases";"GLI3 is processed to GLI3R by the proteasome";"Ub-specific processing proteases";"Degradation of beta-catenin by the destruction complex";"Ubiquitin-dependent degradation of Cyclin D";"Regulation of RUNX2 expression and activity";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Degradation of GLI1 by the proteasome";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Dectin-1 mediated noncanonical NF-kB signaling";"Vpu mediated degradation of CD4";"Autodegradation of the E3 ubiquitin ligase COP1";"Cross-presentation of soluble exogenous antigens (endosomes)";"Hedgehog 'on' state";"Autodegradation of Cdh1 by Cdh1:APC/C";"SCF(Skp2)-mediated degradation of p27/p21";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"ER-Phagosome pathway";"Degradation of GLI2 by the proteasome";"Negative regulation of NOTCH4 signaling";"CDT1 association with the CDC6:ORC:origin complex";"Regulation of PTEN stability and activity";"NIK-->noncanonical NF-kB signaling";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"CDK-mediated phosphorylation and removal of Cdc6";"Degradation of AXIN";"SCF-beta-TrCP mediated degradation of Emi1";"G2/M Checkpoints";"Regulation of ornithine decarboxylase (ODC)";"Defective CFTR causes cystic fibrosis";"FCERI mediated NF-kB activation";"Neddylation";"CLEC7A (Dectin-1) signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"APC/C:Cdc20 mediated degradation of Securin";"Activation of NF-kappaB in B cells"
Medex_00044431-RA	34	Reactome: R-HSA-168333;Reactome: R-HSA-1169408;Reactome: R-HSA-2467813;Reactome: R-HSA-68877;Reactome: R-HSA-9648025;Reactome: R-HSA-159231;Reactome: R-HSA-159227;Reactome: R-HSA-159230;Reactome: R-HSA-5663220;Reactome: R-HSA-168271;Reactome: R-HSA-3232142;Reactome: R-HSA-170822;Reactome: R-HSA-4551638;Reactome: R-HSA-141444;Reactome: R-HSA-191859;Reactome: R-HSA-168325;Reactome: R-HSA-165054;Reactome: R-HSA-9639288;Reactome: R-HSA-180746;Reactome: R-HSA-4615885;Reactome: R-HSA-3371453;Reactome: R-HSA-2500257;Reactome: R-HSA-5578749;Reactome: R-HSA-168276;Reactome: R-HSA-180910;Reactome: R-HSA-3301854;Reactome: R-HSA-4085377;Reactome: R-HSA-4570464;Reactome: R-HSA-5619107;Reactome: R-HSA-9610379;Reactome: R-HSA-9609690;Reactome: R-HSA-6784531;Reactome: R-HSA-3108214;Reactome: R-HSA-159236	"NEP/NS2 Interacts with the Cellular Export Machinery";"ISG15 antiviral mechanism";"Separation of Sister Chromatids";"Mitotic Prometaphase";"EML4 and NUDC in mitotic spindle formation";"Transport of Mature mRNA Derived from an Intronless Transcript";"Transport of the SLBP independent Mature mRNA";"Transport of the SLBP Dependant Mature mRNA";"RHO GTPases Activate Formins";"Transport of Ribonucleoproteins into the Host Nucleus";"SUMOylation of ubiquitinylation proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"SUMOylation of chromatin organization proteins";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"snRNP Assembly";"Viral Messenger RNA Synthesis";"Rev-mediated nuclear export of HIV RNA";"Amino acids regulate mTORC1";"Nuclear import of Rev protein";"SUMOylation of DNA replication proteins";"Regulation of HSF1-mediated heat shock response";"Resolution of Sister Chromatid Cohesion";"Transcriptional regulation by small RNAs";"NS1 Mediated Effects on Host Pathways";"Vpr-mediated nuclear import of PICs";"Nuclear Pore Complex (NPC) Disassembly";"SUMOylation of SUMOylation proteins";"SUMOylation of RNA binding proteins";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"HCMV Late Events";"HCMV Early Events";"tRNA processing in the nucleus";"SUMOylation of DNA damage response and repair proteins";"Transport of Mature mRNA derived from an Intron-Containing Transcript"
Medex_00085316-RA	1	Reactome: R-HSA-425986	"Sodium/Proton exchangers"
Medex_00028829-RA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
Medex_00085514-RA	1	Reactome: R-HSA-6811434	"COPI-dependent Golgi-to-ER retrograde traffic"
Medex_00011496-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Medex_00054233-RA	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00042050-RA	1	Reactome: R-HSA-5663220	"RHO GTPases Activate Formins"
Medex_00003976-RA	6	KEGG: 00073+1.2.1.84;MetaCyc: PWY-7656;MetaCyc: PWY-7782;MetaCyc: PWY-6733;Reactome: R-HSA-9640463;MetaCyc: PWY-5884	"Cutin, suberine and wax biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Plasmalogen biosynthesis";"Sporopollenin precursors biosynthesis";"Wax biosynthesis";"Wax esters biosynthesis I"
Medex_00098757-RA	3	KEGG: 00480+4.3.2.7;MetaCyc: PWY-7942;Reactome: R-HSA-174403	"Glutathione metabolism";"5-oxo-L-proline metabolism";"Glutathione synthesis and recycling"
Medex_00029303-RA	1	Reactome: R-HSA-6798163	"Choline catabolism"
Medex_00000692-RA	1	MetaCyc: PWY-6938	"NADH repair"
Medex_00003515-RA	2	Reactome: R-HSA-9634600;KEGG: 00051+2.7.1.105+3.1.3.46	"Regulation of glycolysis by fructose 2,6-bisphosphate metabolism";"Fructose and mannose metabolism"
Medex_00043669-RA	6	Reactome: R-HSA-912446;Reactome: R-HSA-5693554;Reactome: R-HSA-5693568;Reactome: R-HSA-5693616;Reactome: R-HSA-5693579;Reactome: R-HSA-5685942	"Meiotic recombination";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Resolution of D-loop Structures through Holliday Junction Intermediates";"Presynaptic phase of homologous DNA pairing and strand exchange";"Homologous DNA Pairing and Strand Exchange";"HDR through Homologous Recombination (HRR)"
Medex_00092492-RA	2	KEGG: 00970+6.1.1.7;Reactome: R-HSA-379716	"Aminoacyl-tRNA biosynthesis";"Cytosolic tRNA aminoacylation"
Medex_00054639-RA	2	Reactome: R-HSA-532668;KEGG: 00511+3.2.1.96	"N-glycan trimming in the ER and Calnexin/Calreticulin cycle";"Other glycan degradation"
Medex_00071547-RA	7	Reactome: R-HSA-5628897;Reactome: R-HSA-380972;Reactome: R-HSA-166208;Reactome: R-HSA-8943724;Reactome: R-HSA-1632852;Reactome: R-HSA-165159;Reactome: R-HSA-9639288	"TP53 Regulates Metabolic Genes";"Energy dependent regulation of mTOR by LKB1-AMPK";"mTORC1-mediated signalling";"Regulation of PTEN gene transcription";"Macroautophagy";"mTOR signalling";"Amino acids regulate mTORC1"
Medex_00021133-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Medex_00089231-RA	52	Reactome: R-HSA-167238;Reactome: R-HSA-6796648;Reactome: R-HSA-72086;Reactome: R-HSA-72203;Reactome: R-HSA-427413;Reactome: R-HSA-77075;Reactome: R-HSA-168325;Reactome: R-HSA-6781827;Reactome: R-HSA-167158;Reactome: R-HSA-73762;Reactome: R-HSA-6803529;Reactome: R-HSA-167162;Reactome: R-HSA-76042;Reactome: R-HSA-76061;Reactome: R-HSA-72165;Reactome: R-HSA-73780;Reactome: R-HSA-73772;Reactome: R-HSA-6782210;Reactome: R-HSA-167152;Reactome: R-HSA-674695;Reactome: R-HSA-73776;Reactome: R-HSA-73863;Reactome: R-HSA-167243;Reactome: R-HSA-167287;Reactome: R-HSA-73980;Reactome: R-HSA-76071;Reactome: R-HSA-112382;Reactome: R-HSA-73779;Reactome: R-HSA-8851708;Reactome: R-HSA-167161;Reactome: R-HSA-75953;Reactome: R-HSA-6807505;Reactome: R-HSA-1834949;Reactome: R-HSA-113418;Reactome: R-HSA-75955;Reactome: R-HSA-9018519;Reactome: R-HSA-6782135;Reactome: R-HSA-5617472;Reactome: R-HSA-203927;Reactome: R-HSA-5601884;Reactome: R-HSA-5578749;Reactome: R-HSA-167160;Reactome: R-HSA-167246;Reactome: R-HSA-167200;Reactome: R-HSA-72163;Reactome: R-HSA-167290;Reactome: R-HSA-6781823;Reactome: R-HSA-167172;Reactome: R-HSA-167242;Reactome: R-HSA-749476;Reactome: R-HSA-5250924;Reactome: R-HSA-76066	"Pausing and recovery of Tat-mediated HIV elongation";"TP53 Regulates Transcription of DNA Repair Genes";"mRNA Capping";"Processing of Capped Intron-Containing Pre-mRNA";"NoRC negatively regulates rRNA expression";"RNA Pol II CTD phosphorylation and interaction with CE";"Viral Messenger RNA Synthesis";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Formation of the HIV-1 Early Elongation Complex";"RNA Polymerase I Transcription Initiation";"FGFR2 alternative splicing";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"mRNA Splicing - Minor Pathway";"RNA Polymerase III Chain Elongation";"RNA Polymerase I Promoter Escape";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Promoter Escape";"RNA Polymerase I Transcription Termination";"Tat-mediated HIV elongation arrest and recovery";"HIV elongation arrest and recovery";"RNA Polymerase III Transcription Termination";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"Formation of RNA Pol II elongation complex";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Signaling by FGFR2 IIIa TM";"HIV Transcription Initiation";"RNA Polymerase II Transcription Initiation";"RNA polymerase II transcribes snRNA genes";"Cytosolic sensors of pathogen-associated DNA";"Formation of the Early Elongation Complex";"RNA Polymerase II Transcription Elongation";"Estrogen-dependent gene expression";"Dual incision in TC-NER";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"MicroRNA (miRNA) biogenesis";"PIWI-interacting RNA (piRNA) biogenesis";"Transcriptional regulation by small RNAs";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Tat-mediated elongation of the HIV-1 transcript";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"mRNA Splicing - Major Pathway";"Pausing and recovery of HIV elongation";"Formation of TC-NER Pre-Incision Complex";"Transcription of the HIV genome";"Abortive elongation of HIV-1 transcript in the absence of Tat";"RNA Polymerase III Abortive And Retractive Initiation";"B-WICH complex positively regulates rRNA expression";"RNA Polymerase III Transcription Initiation From Type 2 Promoter"
Medex_00060891-RA	5	KEGG: 00920+2.7.1.25;KEGG: 00230+2.7.1.25;MetaCyc: PWY-5340;Reactome: R-HSA-174362;Reactome: R-HSA-2408550	"Sulfur metabolism";"Purine metabolism";"Sulfate activation for sulfonation";"Transport and synthesis of PAPS";"Metabolism of ingested H2SeO4 and H2SeO3 into H2Se"
Medex_00040920-RA	1	Reactome: R-HSA-426117	"Cation-coupled Chloride cotransporters"
Medex_00053305-RA	4	Reactome: R-HSA-917977;Reactome: R-HSA-983712;Reactome: R-HSA-77387;Reactome: R-HSA-1222556	"Transferrin endocytosis and recycling";"Ion channel transport";"Insulin receptor recycling";"ROS and RNS production in phagocytes"
Medex_00048321-RA	2	Reactome: R-HSA-3214815;Reactome: R-HSA-427413	"HDACs deacetylate histones";"NoRC negatively regulates rRNA expression"
Medex_00027214-RA	2	Reactome: R-HSA-5601884;Reactome: R-HSA-1221632	"PIWI-interacting RNA (piRNA) biogenesis";"Meiotic synapsis"
Medex_00034922-RA	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
Medex_00011997-RA	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
Medex_00009309-RA	4	KEGG: 00330+1.5.5.2;Reactome: R-HSA-70688;MetaCyc: PWY-6922;MetaCyc: PWY-5737	"Arginine and proline metabolism";"Proline catabolism";"L-Ndelta-acetylornithine biosynthesis";"(5R)-carbapenem carboxylate biosynthesis"
Medex_00052487-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Medex_00042971-RA	1	Reactome: R-HSA-203927	"MicroRNA (miRNA) biogenesis"
Medex_00062385-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Medex_00021475-RA	5	Reactome: R-HSA-983712;Reactome: R-HSA-77387;Reactome: R-HSA-9639288;Reactome: R-HSA-1222556;Reactome: R-HSA-917977	"Ion channel transport";"Insulin receptor recycling";"Amino acids regulate mTORC1";"ROS and RNS production in phagocytes";"Transferrin endocytosis and recycling"
Medex_00002707-RA	1	Reactome: R-HSA-8951664	"Neddylation"
Medex_00041100-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00041599-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00034579-RA	6	Reactome: R-HSA-5693616;Reactome: R-HSA-176187;Reactome: R-HSA-69473;Reactome: R-HSA-5693607;Reactome: R-HSA-6804756;Reactome: R-HSA-5685938	"Presynaptic phase of homologous DNA pairing and strand exchange";"Activation of ATR in response to replication stress";"G2/M DNA damage checkpoint";"Processing of DNA double-strand break ends";"Regulation of TP53 Activity through Phosphorylation";"HDR through Single Strand Annealing (SSA)"
Medex_00071199-RA	1	Reactome: R-HSA-156842	"Eukaryotic Translation Elongation"
Medex_00033933-RA	8	KEGG: 00240+2.7.4.9;MetaCyc: PWY-7210;MetaCyc: PWY-6545;MetaCyc: PWY-7198;Reactome: R-HSA-499943;MetaCyc: PWY-7184;MetaCyc: PWY-7187;MetaCyc: PWY-7197	"Pyrimidine metabolism";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Interconversion of nucleotide di- and triphosphates";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Pyrimidine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotide phosphorylation"
Medex_00038875-RA	1	Reactome: R-HSA-8951664	"Neddylation"
Medex_00026134-RA	3	Reactome: R-HSA-6807878;Reactome: R-HSA-6811440;Reactome: R-HSA-6811438	"COPI-mediated anterograde transport";"Retrograde transport at the Trans-Golgi-Network";"Intra-Golgi traffic"
Medex_00015464-RA	3	Reactome: R-HSA-430039;Reactome: R-HSA-450513;Reactome: R-HSA-450385	"mRNA decay by 5' to 3' exoribonuclease";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA"
Medex_00081577-RA	3	KEGG: 00730+3.1.3.1;KEGG: 00790+3.1.3.1;MetaCyc: PWY-5491	"Thiamine metabolism";"Folate biosynthesis";"Diethylphosphate degradation"
Medex_00051434-RA	3	Reactome: R-HSA-2029482;Reactome: R-HSA-5663213;Reactome: R-HSA-202433	"Regulation of actin dynamics for phagocytic cup formation";"RHO GTPases Activate WASPs and WAVEs";"Generation of second messenger molecules"
Medex_00036731-RA	8	Reactome: R-HSA-68827;Reactome: R-HSA-113507;Reactome: R-HSA-68962;Reactome: R-HSA-68689;Reactome: R-HSA-176187;Reactome: R-HSA-68867;Reactome: R-HSA-68949;Reactome: R-HSA-68616	"CDT1 association with the CDC6:ORC:origin complex";"E2F-enabled inhibition of pre-replication complex formation";"Activation of the pre-replicative complex";"CDC6 association with the ORC:origin complex";"Activation of ATR in response to replication stress";"Assembly of the pre-replicative complex";"Orc1 removal from chromatin";"Assembly of the ORC complex at the origin of replication"
Medex_00074308-RA	2	Reactome: R-HSA-163210;Reactome: R-HSA-8949613	"Formation of ATP by chemiosmotic coupling";"Cristae formation"
Medex_00052592-RA	52	Reactome: R-HSA-73980;Reactome: R-HSA-76071;Reactome: R-HSA-112382;Reactome: R-HSA-73779;Reactome: R-HSA-8851708;Reactome: R-HSA-75953;Reactome: R-HSA-167161;Reactome: R-HSA-6807505;Reactome: R-HSA-1834949;Reactome: R-HSA-113418;Reactome: R-HSA-9018519;Reactome: R-HSA-75955;Reactome: R-HSA-6782135;Reactome: R-HSA-5617472;Reactome: R-HSA-203927;Reactome: R-HSA-5601884;Reactome: R-HSA-167246;Reactome: R-HSA-167160;Reactome: R-HSA-5578749;Reactome: R-HSA-167200;Reactome: R-HSA-72163;Reactome: R-HSA-167172;Reactome: R-HSA-6781823;Reactome: R-HSA-167290;Reactome: R-HSA-167242;Reactome: R-HSA-749476;Reactome: R-HSA-76066;Reactome: R-HSA-5250924;Reactome: R-HSA-167238;Reactome: R-HSA-6796648;Reactome: R-HSA-72086;Reactome: R-HSA-427413;Reactome: R-HSA-72203;Reactome: R-HSA-168325;Reactome: R-HSA-77075;Reactome: R-HSA-6781827;Reactome: R-HSA-167158;Reactome: R-HSA-73762;Reactome: R-HSA-6803529;Reactome: R-HSA-167162;Reactome: R-HSA-76042;Reactome: R-HSA-76061;Reactome: R-HSA-72165;Reactome: R-HSA-73780;Reactome: R-HSA-73772;Reactome: R-HSA-6782210;Reactome: R-HSA-167152;Reactome: R-HSA-674695;Reactome: R-HSA-73776;Reactome: R-HSA-167287;Reactome: R-HSA-167243;Reactome: R-HSA-73863	"RNA Polymerase III Transcription Termination";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"Formation of RNA Pol II elongation complex";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Signaling by FGFR2 IIIa TM";"RNA Polymerase II Transcription Initiation";"HIV Transcription Initiation";"RNA polymerase II transcribes snRNA genes";"Cytosolic sensors of pathogen-associated DNA";"Formation of the Early Elongation Complex";"Estrogen-dependent gene expression";"RNA Polymerase II Transcription Elongation";"Dual incision in TC-NER";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"MicroRNA (miRNA) biogenesis";"PIWI-interacting RNA (piRNA) biogenesis";"Tat-mediated elongation of the HIV-1 transcript";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Transcriptional regulation by small RNAs";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"mRNA Splicing - Major Pathway";"Transcription of the HIV genome";"Formation of TC-NER Pre-Incision Complex";"Pausing and recovery of HIV elongation";"Abortive elongation of HIV-1 transcript in the absence of Tat";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"B-WICH complex positively regulates rRNA expression";"Pausing and recovery of Tat-mediated HIV elongation";"TP53 Regulates Transcription of DNA Repair Genes";"mRNA Capping";"NoRC negatively regulates rRNA expression";"Processing of Capped Intron-Containing Pre-mRNA";"Viral Messenger RNA Synthesis";"RNA Pol II CTD phosphorylation and interaction with CE";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Formation of the HIV-1 Early Elongation Complex";"RNA Polymerase I Transcription Initiation";"FGFR2 alternative splicing";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"mRNA Splicing - Minor Pathway";"RNA Polymerase III Chain Elongation";"RNA Polymerase I Promoter Escape";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Promoter Escape";"HIV elongation arrest and recovery";"Tat-mediated HIV elongation arrest and recovery";"RNA Polymerase I Transcription Termination"
Medex_00022604-RA	1	Reactome: R-HSA-5693571	"Nonhomologous End-Joining (NHEJ)"
Medex_00040808-RA	14	Reactome: R-HSA-5656121;Reactome: R-HSA-6782210;Reactome: R-HSA-5696397;Reactome: R-HSA-110312;Reactome: R-HSA-5685942;Reactome: R-HSA-6782135;Reactome: R-HSA-5655862;Reactome: R-HSA-110314;Reactome: R-HSA-174411;Reactome: R-HSA-5696400;Reactome: R-HSA-69091;Reactome: R-HSA-110320;Reactome: R-HSA-5656169;Reactome: R-HSA-5651801	"Translesion synthesis by POLI";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Translesion synthesis by REV1";"HDR through Homologous Recombination (HRR)";"Dual incision in TC-NER";"Translesion synthesis by POLK";"Recognition of DNA damage by PCNA-containing replication complex";"Polymerase switching on the C-strand of the telomere";"Dual Incision in GG-NER";"Polymerase switching";"Translesion Synthesis by POLH";"Termination of translesion DNA synthesis";"PCNA-Dependent Long Patch Base Excision Repair"
Medex_00059113-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00093602-RA	2	KEGG: 00520+5.4.2.10;MetaCyc: PWY-6749	"Amino sugar and nucleotide sugar metabolism";"CMP-legionaminate biosynthesis I"
Medex_00022895-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00068798-RA	14	MetaCyc: PWY-5080;MetaCyc: PWY-8041;MetaCyc: PWY-7725;MetaCyc: PWY-6598;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7724;MetaCyc: PWY-7601;MetaCyc: PWY-7035;Reactome: R-HSA-75876;MetaCyc: PWY-5972;MetaCyc: PWY-7619;MetaCyc: PWY-7602;MetaCyc: PWY-7036;MetaCyc: PWY-6433	"Very long chain fatty acid biosynthesis I";"Ultra-long-chain fatty acid biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Sciadonate biosynthesis";"Fatty acid elongation";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"(9Z)-tricosene biosynthesis";"Synthesis of very long-chain fatty acyl-CoAs";"Stearate biosynthesis I (animals)";"Juniperonate biosynthesis";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis II";"Hydroxylated fatty acid biosynthesis (plants)"
Medex_00062130-RA	10	KEGG: 00670+2.1.1.45;MetaCyc: PWY-7199;KEGG: 00240+2.1.1.45;MetaCyc: PWY-7210;MetaCyc: PWY-7187;MetaCyc: PWY-7184;MetaCyc: PWY-3841;Reactome: R-HSA-499943;Reactome: R-HSA-69205;MetaCyc: PWY-7198	"One carbon pool by folate";"Pyrimidine deoxyribonucleosides salvage";"Pyrimidine metabolism";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Pyrimidine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Folate transformations II (plants)";"Interconversion of nucleotide di- and triphosphates";"G1/S-Specific Transcription";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV"
Medex_00025542-RA	2	KEGG: 00270+3.3.1.1;MetaCyc: PWY-5041	"Cysteine and methionine metabolism";"S-adenosyl-L-methionine cycle II"
Medex_00024251-RA	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
Medex_00041215-RA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
Medex_00062544-RA	2	Reactome: R-HSA-5689880;Reactome: R-HSA-8949215	"Ub-specific processing proteases";"Mitochondrial calcium ion transport"
Medex_00026466-RA	8	KEGG: 00950+1.14.16.2;MetaCyc: PWY-6133;MetaCyc: PWY-5049;Reactome: R-HSA-209905;MetaCyc: PWY-3581;KEGG: 00790+1.14.16.2;MetaCyc: PWY-5394;KEGG: 00350+1.14.16.2	"Isoquinoline alkaloid biosynthesis";"(S)-reticuline biosynthesis II";"Rosmarinic acid biosynthesis II";"Catecholamine biosynthesis";"(S)-reticuline biosynthesis I";"Folate biosynthesis";"Betalamic acid biosynthesis";"Tyrosine metabolism"
Medex_00016066-RA	3	Reactome: R-HSA-110312;Reactome: R-HSA-5656121;Reactome: R-HSA-5655862	"Translesion synthesis by REV1";"Translesion synthesis by POLI";"Translesion synthesis by POLK"
Medex_00019594-RA	25	Reactome: R-HSA-2500257;Reactome: R-HSA-380320;Reactome: R-HSA-3371497;Reactome: R-HSA-5663220;Reactome: R-HSA-1445148;Reactome: R-HSA-68877;Reactome: R-HSA-6811434;Reactome: R-HSA-380270;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813;Reactome: R-HSA-5617833;Reactome: R-HSA-9646399;Reactome: R-HSA-5626467;Reactome: R-HSA-2132295;Reactome: R-HSA-437239;Reactome: R-HSA-6807878;Reactome: R-HSA-9619483;Reactome: R-HSA-190840;Reactome: R-HSA-190861;Reactome: R-HSA-9609690;Reactome: R-HSA-6811436;Reactome: R-HSA-8955332;Reactome: R-HSA-8852276;Reactome: R-HSA-983189;Reactome: R-HSA-9609736	"Resolution of Sister Chromatid Cohesion";"Recruitment of NuMA to mitotic centrosomes";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"RHO GTPases Activate Formins";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Mitotic Prometaphase";"COPI-dependent Golgi-to-ER retrograde traffic";"Recruitment of mitotic centrosome proteins and complexes";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids";"Cilium Assembly";"Aggrephagy";"RHO GTPases activate IQGAPs";"MHC class II antigen presentation";"Recycling pathway of L1";"COPI-mediated anterograde transport";"Activation of AMPK downstream of NMDARs";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Gap junction assembly";"HCMV Early Events";"COPI-independent Golgi-to-ER retrograde traffic";"Carboxyterminal post-translational modifications of tubulin";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Kinesins";"Assembly and cell surface presentation of NMDA receptors"
Medex_00069336-RA	6	KEGG: 00604+3.2.1.23;MetaCyc: PWY-6807;KEGG: 00600+3.2.1.23;KEGG: 00511+3.2.1.23;KEGG: 00052+3.2.1.23;KEGG: 00531+3.2.1.23	"Glycosphingolipid biosynthesis - ganglio series";"Xyloglucan degradation II (exoglucanase)";"Sphingolipid metabolism";"Other glycan degradation";"Galactose metabolism";"Glycosaminoglycan degradation"
Medex_00008525-RA	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
Medex_00016732-RA	14	MetaCyc: PWY-3841;MetaCyc: PWY-2161;KEGG: 00670+2.1.2.1;KEGG: 00680+2.1.2.1;MetaCyc: PWY-1622;MetaCyc: PWY-3661-1;KEGG: 00630+2.1.2.1;Reactome: R-HSA-196757;KEGG: 00460+2.1.2.1;MetaCyc: PWY-3661;MetaCyc: PWY-2201;KEGG: 00260+2.1.2.1;MetaCyc: PWY-5497;MetaCyc: PWY-181	"Folate transformations II (plants)";"Folate polyglutamylation";"One carbon pool by folate";"Methane metabolism";"Formaldehyde assimilation I (serine pathway)";"Glycine betaine degradation II (mammalian)";"Glyoxylate and dicarboxylate metabolism";"Metabolism of folate and pterines";"Cyanoamino acid metabolism";"Glycine betaine degradation I";"Folate transformations I";"Glycine, serine and threonine metabolism";"Purine nucleobases degradation II (anaerobic)";"Photorespiration "
Medex_00066731-RA	6	MetaCyc: PWY-5884;Reactome: R-HSA-9640463;KEGG: 00073+1.2.1.84;MetaCyc: PWY-7782;MetaCyc: PWY-6733;MetaCyc: PWY-7656	"Wax esters biosynthesis I";"Wax biosynthesis";"Cutin, suberine and wax biosynthesis";"Plasmalogen biosynthesis";"Sporopollenin precursors biosynthesis";"Spodoptera littoralis pheromone biosynthesis"
Medex_00036111-RA	6	KEGG: 00052+3.2.1.23;KEGG: 00531+3.2.1.23;KEGG: 00604+3.2.1.23;KEGG: 00600+3.2.1.23;KEGG: 00511+3.2.1.23;MetaCyc: PWY-6807	"Galactose metabolism";"Glycosaminoglycan degradation";"Glycosphingolipid biosynthesis - ganglio series";"Sphingolipid metabolism";"Other glycan degradation";"Xyloglucan degradation II (exoglucanase)"
Medex_00049192-RA	3	MetaCyc: PWY-3961;Reactome: R-HSA-196783;KEGG: 00770+2.7.1.33	"Phosphopantothenate biosynthesis II";"Coenzyme A biosynthesis";"Pantothenate and CoA biosynthesis"
Medex_00051569-RA	2	Reactome: R-HSA-5223345;Reactome: R-HSA-425393	"Miscellaneous transport and binding events";"Transport of inorganic cations/anions and amino acids/oligopeptides"
Medex_00080144-RA	57	Reactome: R-HSA-195253;Reactome: R-HSA-75815;Reactome: R-HSA-8939902;Reactome: R-HSA-4608870;Reactome: R-HSA-5687128;Reactome: R-HSA-5689603;Reactome: R-HSA-5668541;Reactome: R-HSA-5689880;Reactome: R-HSA-5610785;Reactome: R-HSA-180534;Reactome: R-HSA-1236978;Reactome: R-HSA-349425;Reactome: R-HSA-5632684;Reactome: R-HSA-174178;Reactome: R-HSA-5610780;Reactome: R-HSA-8852276;Reactome: R-HSA-5607761;Reactome: R-HSA-202424;Reactome: R-HSA-983168;Reactome: R-HSA-5358346;Reactome: R-HSA-8941858;Reactome: R-HSA-5658442;Reactome: R-HSA-6798695;Reactome: R-HSA-9020702;Reactome: R-HSA-450408;Reactome: R-HSA-180585;Reactome: R-HSA-2467813;Reactome: R-HSA-4641258;Reactome: R-HSA-382556;Reactome: R-HSA-211733;Reactome: R-HSA-68949;Reactome: R-HSA-8939236;Reactome: R-HSA-9010553;Reactome: R-HSA-4641257;Reactome: R-HSA-174113;Reactome: R-HSA-350562;Reactome: R-HSA-5678895;Reactome: R-HSA-69481;Reactome: R-HSA-68827;Reactome: R-HSA-8948751;Reactome: R-HSA-9604323;Reactome: R-HSA-5676590;Reactome: R-HSA-1234176;Reactome: R-HSA-69017;Reactome: R-HSA-5362768;Reactome: R-HSA-69601;Reactome: R-HSA-5607764;Reactome: R-HSA-174184;Reactome: R-HSA-174154;Reactome: R-HSA-1169091;Reactome: R-HSA-2871837;Reactome: R-HSA-8951664;Reactome: R-HSA-174084;Reactome: R-HSA-187577;Reactome: R-HSA-8854050;Reactome: R-HSA-1236974;Reactome: R-HSA-5610783	"Degradation of beta-catenin by the destruction complex";"Ubiquitin-dependent degradation of Cyclin D";"Regulation of RUNX2 expression and activity";"Asymmetric localization of PCP proteins";"MAPK6/MAPK4 signaling";"UCH proteinases";"TNFR2 non-canonical NF-kB pathway";"Ub-specific processing proteases";"GLI3 is processed to GLI3R by the proteasome";"Vpu mediated degradation of CD4";"Cross-presentation of soluble exogenous antigens (endosomes)";"Autodegradation of the E3 ubiquitin ligase COP1";"Hedgehog 'on' state";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Degradation of GLI1 by the proteasome";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Dectin-1 mediated noncanonical NF-kB signaling";"Downstream TCR signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Hedgehog ligand biogenesis";"Regulation of RUNX3 expression and activity";"Regulation of RAS by GAPs";"Neutrophil degranulation";"Interleukin-1 signaling";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Vif-mediated degradation of APOBEC3G";"Separation of Sister Chromatids";"Degradation of DVL";"ABC-family proteins mediated transport";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Orc1 removal from chromatin";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Regulation of expression of SLITs and ROBOs";"Degradation of AXIN";"SCF-beta-TrCP mediated degradation of Emi1";"Regulation of ornithine decarboxylase (ODC)";"Defective CFTR causes cystic fibrosis";"G2/M Checkpoints";"CDT1 association with the CDC6:ORC:origin complex";"Regulation of PTEN stability and activity";"Negative regulation of NOTCH4 signaling";"NIK-->noncanonical NF-kB signaling";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"CDK-mediated phosphorylation and removal of Cdc6";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"CLEC7A (Dectin-1) signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"APC/C:Cdc20 mediated degradation of Securin";"Activation of NF-kappaB in B cells";"FCERI mediated NF-kB activation";"Neddylation";"Autodegradation of Cdh1 by Cdh1:APC/C";"SCF(Skp2)-mediated degradation of p27/p21";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"ER-Phagosome pathway";"Degradation of GLI2 by the proteasome"
Medex_00068318-RA	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
Medex_00047560-RA	16	Reactome: R-HSA-192823;Reactome: R-HSA-72649;Reactome: R-HSA-72695;Reactome: R-HSA-156902;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-72689;Reactome: R-HSA-2408557;Reactome: R-HSA-975957;Reactome: R-HSA-1799339;Reactome: R-HSA-9633012;Reactome: R-HSA-72706;Reactome: R-HSA-975956;Reactome: R-HSA-72764;Reactome: R-HSA-72702;Reactome: R-HSA-6791226	"Viral mRNA Translation";"Translation initiation complex formation";"Formation of the ternary complex, and subsequently, the 43S complex";"Peptide chain elongation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Formation of a pool of free 40S subunits";"Selenocysteine synthesis";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Ribosomal scanning and start codon recognition";"Major pathway of rRNA processing in the nucleolus and cytosol"
Medex_00064331-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Medex_00009743-RA	3	KEGG: 00480+4.3.2.7;Reactome: R-HSA-174403;MetaCyc: PWY-7942	"Glutathione metabolism";"Glutathione synthesis and recycling";"5-oxo-L-proline metabolism"
Medex_00030825-RA	11	MetaCyc: PWY-7206;KEGG: 00500+3.6.1.9;KEGG: 00770+3.6.1.9;KEGG: 00760+3.6.1.9;MetaCyc: PWY-7184;MetaCyc: PWY-7187;MetaCyc: PWY-6545;KEGG: 00230+3.6.1.9;MetaCyc: PWY-7821;KEGG: 00740+3.6.1.9;KEGG: 00240+3.6.1.9	"Pyrimidine deoxyribonucleotides dephosphorylation";"Starch and sucrose metabolism";"Pantothenate and CoA biosynthesis";"Nicotinate and nicotinamide metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Pyrimidine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Purine metabolism";"Tunicamycin biosynthesis";"Riboflavin metabolism";"Pyrimidine metabolism"
Medex_00000118-RA	13	Reactome: R-HSA-139853;Reactome: R-HSA-983695;Reactome: R-HSA-1489509;Reactome: R-HSA-2029485;Reactome: R-HSA-422356;Reactome: R-HSA-112043;Reactome: R-HSA-4086398;Reactome: R-HSA-2871809;Reactome: R-HSA-5607763;Reactome: R-HSA-5578775;Reactome: R-HSA-114508;Reactome: R-HSA-5218921;Reactome: R-HSA-381676	"Elevation of cytosolic Ca2+ levels";"Antigen activates B Cell Receptor (BCR) leading to generation of second messengers";"DAG and IP3 signaling";"Role of phospholipids in phagocytosis";"Regulation of insulin secretion";"PLC beta mediated events";"Ca2+ pathway";"FCERI mediated Ca+2 mobilization";"CLEC7A (Dectin-1) induces NFAT activation";"Ion homeostasis";"Effects of PIP2 hydrolysis";"VEGFR2 mediated cell proliferation";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion"
Medex_00102913-RA	2	Reactome: R-HSA-9635465;Reactome: R-HSA-983168	"Suppression of apoptosis";"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00090821-RA	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
Medex_00048452-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00021789-RA	1	Reactome: R-HSA-3299685	"Detoxification of Reactive Oxygen Species"
Medex_00047261-RA	1	Reactome: R-HSA-1971475	"A tetrasaccharide linker sequence is required for GAG synthesis"
Medex_00041918-RA	4	Reactome: R-HSA-6807047;KEGG: 00100+1.3.1.72;MetaCyc: PWY-8026;Reactome: R-HSA-6807062	"Cholesterol biosynthesis via desmosterol";"Steroid biosynthesis";"Sterol biosynthesis (methylotrophs)";"Cholesterol biosynthesis via lathosterol"
Medex_00044603-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00000008-RA	5	Reactome: R-HSA-4341670;Reactome: R-HSA-4085001;Reactome: R-HSA-1660662;Reactome: R-HSA-6798695;Reactome: R-HSA-2132295	"Defective NEU1 causes sialidosis";"Sialic acid metabolism";"Glycosphingolipid metabolism";"Neutrophil degranulation";"MHC class II antigen presentation"
Medex_00057291-RA	1	KEGG: 04660+2.7.10.2	"T cell receptor signaling pathway"
Medex_00048254-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00045704-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Medex_00082935-RA	1	Reactome: R-HSA-8951664	"Neddylation"
Medex_00004703-RA	2	Reactome: R-HSA-8876198;Reactome: R-HSA-8873719	"RAB GEFs exchange GTP for GDP on RABs";"RAB geranylgeranylation"
Medex_00062369-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00078112-RA	6	MetaCyc: PWY-3341;MetaCyc: PWY-6344;MetaCyc: PWY-4981;MetaCyc: PWY-6922;Reactome: R-HSA-8964539;KEGG: 00330+2.6.1.13	"L-proline biosynthesis III (from L-ornithine)";"L-ornithine degradation II (Stickland reaction)";"L-proline biosynthesis II (from arginine)";"L-Ndelta-acetylornithine biosynthesis";"Glutamate and glutamine metabolism";"Arginine and proline metabolism"
Medex_00065956-RA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
Medex_00079818-RA	1	Reactome: R-HSA-426117	"Cation-coupled Chloride cotransporters"
Medex_00090383-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00017426-RA	2	Reactome: R-HSA-8856825;Reactome: R-HSA-8856828	"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis"
Medex_00020093-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00030302-RA	2	Reactome: R-HSA-8951664;Reactome: R-HSA-983168	"Neddylation";"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00096334-RA	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
Medex_00007089-RA	1	Reactome: R-HSA-425366	"Transport of bile salts and organic acids, metal ions and amine compounds"
Medex_00005189-RA	1	Reactome: R-HSA-211981	"Xenobiotics"
Medex_00089520-RA	3	Reactome: R-HSA-1614558;Reactome: R-HSA-1614603;Reactome: R-HSA-2408508	"Degradation of cysteine and homocysteine";"Cysteine formation from homocysteine";"Metabolism of ingested SeMet, Sec, MeSec into H2Se"
Medex_00091908-RA	2	Reactome: R-HSA-3299685;KEGG: 00480+1.11.1.15	"Detoxification of Reactive Oxygen Species";"Glutathione metabolism"
Medex_00005703-RA	1	Reactome: R-HSA-379716	"Cytosolic tRNA aminoacylation"
Medex_00009354-RA	1	Reactome: R-HSA-203927	"MicroRNA (miRNA) biogenesis"
Medex_00015112-RA	5	Reactome: R-HSA-4085001;Reactome: R-HSA-1660662;Reactome: R-HSA-4341670;Reactome: R-HSA-6798695;Reactome: R-HSA-2132295	"Sialic acid metabolism";"Glycosphingolipid metabolism";"Defective NEU1 causes sialidosis";"Neutrophil degranulation";"MHC class II antigen presentation"
Medex_00058415-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Medex_00046470-RA	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
Medex_00080314-RA	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
Medex_00015471-RA	1	Reactome: R-HSA-6798163	"Choline catabolism"
Medex_00068630-RA	9	Reactome: R-HSA-6804756;Reactome: R-HSA-167162;Reactome: R-HSA-76042;Reactome: R-HSA-73779;Reactome: R-HSA-674695;Reactome: R-HSA-73776;Reactome: R-HSA-167161;Reactome: R-HSA-75953;Reactome: R-HSA-167172	"Regulation of TP53 Activity through Phosphorylation";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Promoter Escape";"HIV Transcription Initiation";"RNA Polymerase II Transcription Initiation";"Transcription of the HIV genome"
Medex_00043335-RA	31	MetaCyc: PWY-5966-1;MetaCyc: PWYG-321;MetaCyc: PWY-7663;MetaCyc: PWY-7723;MetaCyc: PWY-6282;MetaCyc: PWY-5994;MetaCyc: PWY-8012;MetaCyc: PWY-5142;MetaCyc: PWY-5366;MetaCyc: PWY-7858;MetaCyc: PWY-7664;Reactome: R-HSA-163765;MetaCyc: PWY-5973;MetaCyc: PWY-5971;Reactome: R-HSA-9029558;Reactome: R-HSA-75105;MetaCyc: PWY-6519;KEGG: 00061+1.1.1.100+2.3.1.85+4.2.1.59+2.3.1.39+2.3.1.41+3.1.2.14;MetaCyc: PWY-4381;Reactome: R-HSA-2426168;MetaCyc: PWY-6113;MetaCyc: PWY-7388;MetaCyc: PWY-8047;Reactome: R-HSA-199220;MetaCyc: PWY-5989;MetaCyc: PWY-5147;KEGG: 00780+1.1.1.100+4.2.1.59+2.3.1.41;MetaCyc: PWY-5367;MetaCyc: PWY-7746;MetaCyc: PWY-6799;MetaCyc: PWY-8049	"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)";"";"Gondoate biosynthesis (anaerobic)";"Bacterial bioluminescence";"Palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate)";"Palmitate biosynthesis (animals and fungi, cytoplasm)";"Mupirocin biosynthesis";"Acyl-[acyl-carrier protein] thioesterase pathway";"Palmitoleate biosynthesis II (plants and bacteria)";"(5Z)-dodecenoate biosynthesis II";"Oleate biosynthesis IV (anaerobic)";"ChREBP activates metabolic gene expression";"Cis-vaccenate biosynthesis";"Palmitate biosynthesis II (bacteria and plant cytoplasm)";"NR1H2 & NR1H3 regulate gene expression linked to lipogenesis";"Fatty acyl-CoA biosynthesis";"8-amino-7-oxononanoate biosynthesis I";"Fatty acid biosynthesis";"Fatty acid biosynthesis initiation (bacteria and plants)";"Activation of gene expression by SREBF (SREBP)";"Superpathway of mycolate biosynthesis";"Octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast)";"Bryostatin biosynthesis";"Vitamin B5 (pantothenate) metabolism";"Stearate biosynthesis II (bacteria and plants)";"Oleate biosynthesis I (plants)";"Biotin metabolism";"Petroselinate biosynthesis";"Mycobacterial sulfolipid biosynthesis";"Fatty acid biosynthesis initiation (plant mitochondria)";"Pederin biosynthesis"
Medex_00049900-RA	3	Reactome: R-HSA-2024096;Reactome: R-HSA-2206282;KEGG: 00531+3.2.1.50	"HS-GAG degradation";"MPS IIIB - Sanfilippo syndrome B";"Glycosaminoglycan degradation"
Medex_00068738-RA	5	Reactome: R-HSA-6781827;Reactome: R-HSA-72163;Reactome: R-HSA-6782135;Reactome: R-HSA-6781823;Reactome: R-HSA-6782210	"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"mRNA Splicing - Major Pathway";"Dual incision in TC-NER";"Formation of TC-NER Pre-Incision Complex";"Gap-filling DNA repair synthesis and ligation in TC-NER"
Medex_00065309-RA	1	Reactome: R-HSA-112308	"Presynaptic depolarization and calcium channel opening"
Medex_00024586-RA	4	Reactome: R-HSA-382556;MetaCyc: PWY-6972;Reactome: R-HSA-5679001;Reactome: R-HSA-189483	"ABC-family proteins mediated transport";"Oleandomycin activation/inactivation";"Defective ABCC2 causes Dubin-Johnson syndrome";"Heme degradation"
Medex_00036721-RA	13	Reactome: R-HSA-72706;Reactome: R-HSA-975956;Reactome: R-HSA-72764;Reactome: R-HSA-72689;Reactome: R-HSA-2408557;Reactome: R-HSA-6791226;Reactome: R-HSA-975957;Reactome: R-HSA-192823;Reactome: R-HSA-1799339;Reactome: R-HSA-9633012;Reactome: R-HSA-156902;Reactome: R-HSA-9010553;Reactome: R-HSA-156827	"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Formation of a pool of free 40S subunits";"Selenocysteine synthesis";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Viral mRNA Translation";"SRP-dependent cotranslational protein targeting to membrane";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression"
Medex_00024356-RA	14	MetaCyc: PWY-7601;MetaCyc: PWY-7724;MetaCyc: PWY-8041;MetaCyc: PWY-5080;MetaCyc: PWY-7725;MetaCyc: PWY-6598;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7619;MetaCyc: PWY-7602;MetaCyc: PWY-7036;MetaCyc: PWY-6433;MetaCyc: PWY-7035;MetaCyc: PWY-5972;Reactome: R-HSA-75876	"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Ultra-long-chain fatty acid biosynthesis";"Very long chain fatty acid biosynthesis I";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Sciadonate biosynthesis";"Fatty acid elongation";"Juniperonate biosynthesis";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis II";"Hydroxylated fatty acid biosynthesis (plants)";"(9Z)-tricosene biosynthesis";"Stearate biosynthesis I (animals)";"Synthesis of very long-chain fatty acyl-CoAs"
Medex_00096706-RA	1	Reactome: R-HSA-5689880	"Ub-specific processing proteases"
Medex_00042574-RA	2	Reactome: R-HSA-1296072;Reactome: R-HSA-5576894	"Voltage gated Potassium channels";"Phase 1 - inactivation of fast Na+ channels"
Medex_00041341-RA	2	Reactome: R-HSA-425397;Reactome: R-HSA-5619061	"Transport of vitamins, nucleosides, and related molecules";"Defective SLC33A1 causes spastic paraplegia 42 (SPG42)"
Medex_00011262-RA	1	Reactome: R-HSA-5620912	"Anchoring of the basal body to the plasma membrane"
Medex_00013325-RA	56	Reactome: R-HSA-202424;Reactome: R-HSA-983168;Reactome: R-HSA-8941858;Reactome: R-HSA-5358346;Reactome: R-HSA-5658442;Reactome: R-HSA-9020702;Reactome: R-HSA-450408;Reactome: R-HSA-180585;Reactome: R-HSA-2467813;Reactome: R-HSA-4641258;Reactome: R-HSA-211733;Reactome: R-HSA-68949;Reactome: R-HSA-8939236;Reactome: R-HSA-382556;Reactome: R-HSA-9010553;Reactome: R-HSA-195253;Reactome: R-HSA-75815;Reactome: R-HSA-8939902;Reactome: R-HSA-4608870;Reactome: R-HSA-5668541;Reactome: R-HSA-5687128;Reactome: R-HSA-5689603;Reactome: R-HSA-5610785;Reactome: R-HSA-5689880;Reactome: R-HSA-180534;Reactome: R-HSA-349425;Reactome: R-HSA-1236978;Reactome: R-HSA-5632684;Reactome: R-HSA-174178;Reactome: R-HSA-5610780;Reactome: R-HSA-8852276;Reactome: R-HSA-5607761;Reactome: R-HSA-174084;Reactome: R-HSA-187577;Reactome: R-HSA-8854050;Reactome: R-HSA-1236974;Reactome: R-HSA-5610783;Reactome: R-HSA-4641257;Reactome: R-HSA-174113;Reactome: R-HSA-69481;Reactome: R-HSA-5678895;Reactome: R-HSA-350562;Reactome: R-HSA-68827;Reactome: R-HSA-9604323;Reactome: R-HSA-8948751;Reactome: R-HSA-5676590;Reactome: R-HSA-5362768;Reactome: R-HSA-69601;Reactome: R-HSA-69017;Reactome: R-HSA-1234176;Reactome: R-HSA-5607764;Reactome: R-HSA-174184;Reactome: R-HSA-174154;Reactome: R-HSA-1169091;Reactome: R-HSA-2871837;Reactome: R-HSA-8951664	"Downstream TCR signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Regulation of RUNX3 expression and activity";"Hedgehog ligand biogenesis";"Regulation of RAS by GAPs";"Interleukin-1 signaling";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Vif-mediated degradation of APOBEC3G";"Separation of Sister Chromatids";"Degradation of DVL";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Orc1 removal from chromatin";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"ABC-family proteins mediated transport";"Regulation of expression of SLITs and ROBOs";"Degradation of beta-catenin by the destruction complex";"Ubiquitin-dependent degradation of Cyclin D";"Regulation of RUNX2 expression and activity";"Asymmetric localization of PCP proteins";"TNFR2 non-canonical NF-kB pathway";"MAPK6/MAPK4 signaling";"UCH proteinases";"GLI3 is processed to GLI3R by the proteasome";"Ub-specific processing proteases";"Vpu mediated degradation of CD4";"Autodegradation of the E3 ubiquitin ligase COP1";"Cross-presentation of soluble exogenous antigens (endosomes)";"Hedgehog 'on' state";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Degradation of GLI1 by the proteasome";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Dectin-1 mediated noncanonical NF-kB signaling";"Autodegradation of Cdh1 by Cdh1:APC/C";"SCF(Skp2)-mediated degradation of p27/p21";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"ER-Phagosome pathway";"Degradation of GLI2 by the proteasome";"Degradation of AXIN";"SCF-beta-TrCP mediated degradation of Emi1";"G2/M Checkpoints";"Defective CFTR causes cystic fibrosis";"Regulation of ornithine decarboxylase (ODC)";"CDT1 association with the CDC6:ORC:origin complex";"Negative regulation of NOTCH4 signaling";"Regulation of PTEN stability and activity";"NIK-->noncanonical NF-kB signaling";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"CDK-mediated phosphorylation and removal of Cdc6";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"CLEC7A (Dectin-1) signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"APC/C:Cdc20 mediated degradation of Securin";"Activation of NF-kappaB in B cells";"FCERI mediated NF-kB activation";"Neddylation"
Medex_00060033-RA	6	Reactome: R-HSA-5663220;Reactome: R-HSA-2467813;Reactome: R-HSA-68877;Reactome: R-HSA-2500257;Reactome: R-HSA-141444;Reactome: R-HSA-9648025	"RHO GTPases Activate Formins";"Separation of Sister Chromatids";"Mitotic Prometaphase";"Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"EML4 and NUDC in mitotic spindle formation"
Medex_00058460-RA	5	Reactome: R-HSA-1834949;Reactome: R-HSA-164843;Reactome: R-HSA-6798695;Reactome: R-HSA-3270619;Reactome: R-HSA-5693571	"Cytosolic sensors of pathogen-associated DNA";"2-LTR circle formation";"Neutrophil degranulation";"IRF3-mediated induction of type I IFN";"Nonhomologous End-Joining (NHEJ)"
Medex_00078019-RA	7	MetaCyc: PWY-6367;KEGG: 04070+3.1.4.11;MetaCyc: PWY-8052;Reactome: R-HSA-1855204;KEGG: 00562+3.1.4.11;MetaCyc: PWY-7039;MetaCyc: PWY-6351	"D-myo-inositol-5-phosphate metabolism";"Phosphatidylinositol signaling system";"2-arachidonoylglycerol biosynthesis";"Synthesis of IP3 and IP4 in the cytosol";"Inositol phosphate metabolism";"Phosphatidate metabolism, as a signaling molecule";"D-myo-inositol (1,4,5)-trisphosphate biosynthesis"
Medex_00057290-RA	1	KEGG: 04660+2.7.10.2	"T cell receptor signaling pathway"
Medex_00028234-RA	2	Reactome: R-HSA-6796648;Reactome: R-HSA-6783310	"TP53 Regulates Transcription of DNA Repair Genes";"Fanconi Anemia Pathway"
Medex_00071870-RA	27	KEGG: 04150+2.7.11.1;Reactome: R-HSA-5610783;Reactome: R-HSA-5250924;Reactome: R-HSA-198323;Reactome: R-HSA-399956;Reactome: R-HSA-5467337;KEGG: 04714+2.7.11.1;Reactome: R-HSA-5467340;KEGG: 04151+2.7.11.1;Reactome: R-HSA-5358747;Reactome: R-HSA-5339716;Reactome: R-HSA-196299;KEGG: 05163+2.7.11.1;Reactome: R-HSA-5358752;Reactome: R-HSA-5674400;Reactome: R-HSA-3371453;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;Reactome: R-HSA-5358751;Reactome: R-HSA-5358749;Reactome: R-HSA-5467348;Reactome: R-HSA-5610785;Reactome: R-HSA-4641262;Reactome: R-HSA-8939902;Reactome: R-HSA-75815;KEGG: 04926+2.7.11.1;Reactome: R-HSA-195253	"mTOR signaling pathway";"Degradation of GLI2 by the proteasome";"B-WICH complex positively regulates rRNA expression";"AKT phosphorylates targets in the cytosol";"CRMPs in Sema3A signaling";"APC truncation mutants have impaired AXIN binding";"Thermogenesis";"AXIN missense mutants destabilize the destruction complex";"PI3K-Akt signaling pathway";"S33 mutants of beta-catenin aren't phosphorylated";"Misspliced GSK3beta mutants stabilize beta-catenin";"Beta-catenin phosphorylation cascade";"Human cytomegalovirus infection";"T41 mutants of beta-catenin aren't phosphorylated";"Constitutive Signaling by AKT1 E17K in Cancer";"Regulation of HSF1-mediated heat shock response";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"S45 mutants of beta-catenin aren't phosphorylated";"S37 mutants of beta-catenin aren't phosphorylated";"Truncations of AMER1 destabilize the destruction complex";"GLI3 is processed to GLI3R by the proteasome";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"Regulation of RUNX2 expression and activity";"Ubiquitin-dependent degradation of Cyclin D";"Relaxin signaling pathway";"Degradation of beta-catenin by the destruction complex"
Medex_00002309-RA	5	Reactome: R-HSA-3214815;Reactome: R-HSA-6804758;Reactome: R-HSA-427389;Reactome: R-HSA-8943724;Reactome: R-HSA-73762	"HDACs deacetylate histones";"Regulation of TP53 Activity through Acetylation";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"Regulation of PTEN gene transcription";"RNA Polymerase I Transcription Initiation"
Medex_00076010-RA	2	Reactome: R-HSA-3238698;Reactome: R-HSA-373080	"WNT ligand biogenesis and trafficking";"Class B/2 (Secretin family receptors)"
Medex_00020707-RA	19	MetaCyc: PWY-7858;MetaCyc: PWY-6837;MetaCyc: PWY-7340;KEGG: 00640+1.3.3.6;MetaCyc: PWY-7606;MetaCyc: PWY-735;MetaCyc: PWY-7291;MetaCyc: PWY-5136;MetaCyc: PWY-7007;MetaCyc: PWY-7338;MetaCyc: PWY-7726;KEGG: 00592+1.3.3.6;MetaCyc: PWY-7854;MetaCyc: PWY-7288;MetaCyc: PWY-6920;KEGG: 00410+1.3.3.6;MetaCyc: PWY-7337;MetaCyc: PWY-7574;KEGG: 00071+1.3.3.6	"(5Z)-dodecenoate biosynthesis II";"Fatty acid beta-oxidation V (unsaturated, odd number, di-isomerase-dependent)";"9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast)";"Propanoate metabolism";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Jasmonic acid biosynthesis";"Oleate beta-oxidation (isomerase-dependent, yeast)";"Fatty acid beta-oxidation II (plant peroxisome)";"Methyl ketone biosynthesis (engineered)";"10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast)";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"alpha-Linolenic acid metabolism";"Crotonyl-coa/ethylmalonyl-coa/hydroxybutyryl-coa cycle (engineered)";"Fatty acid beta-oxidation VII (yeast peroxisome)";"6-gingerol analog biosynthesis (engineered)";"beta-Alanine metabolism";"10-cis-heptadecenoyl-CoA degradation (yeast)";"Propanoyl-coa degradation II";"Fatty acid degradation"
Medex_00025933-RA	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
Medex_00045099-RA	1	Reactome: R-HSA-203927	"MicroRNA (miRNA) biogenesis"
Medex_00004924-RA	18	Reactome: R-HSA-167287;Reactome: R-HSA-167243;Reactome: R-HSA-167152;Reactome: R-HSA-674695;Reactome: R-HSA-167242;Reactome: R-HSA-167290;Reactome: R-HSA-167200;Reactome: R-HSA-167246;Reactome: R-HSA-167160;Reactome: R-HSA-75955;Reactome: R-HSA-113418;Reactome: R-HSA-6807505;Reactome: R-HSA-167158;Reactome: R-HSA-77075;Reactome: R-HSA-72086;Reactome: R-HSA-112382;Reactome: R-HSA-167238;Reactome: R-HSA-6796648	"HIV elongation arrest and recovery";"Tat-mediated HIV elongation arrest and recovery";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Polymerase II Pre-transcription Events";"Abortive elongation of HIV-1 transcript in the absence of Tat";"Pausing and recovery of HIV elongation";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Tat-mediated elongation of the HIV-1 transcript";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"RNA Polymerase II Transcription Elongation";"Formation of the Early Elongation Complex";"RNA polymerase II transcribes snRNA genes";"Formation of the HIV-1 Early Elongation Complex";"RNA Pol II CTD phosphorylation and interaction with CE";"mRNA Capping";"Formation of RNA Pol II elongation complex";"Pausing and recovery of Tat-mediated HIV elongation";"TP53 Regulates Transcription of DNA Repair Genes"
Medex_00006257-RA	2	Reactome: R-HSA-196780;Reactome: R-HSA-3371599	"Biotin transport and metabolism";"Defective HLCS causes multiple carboxylase deficiency"
Medex_00074274-RA	1	Reactome: R-HSA-8964572	"Lipid particle organization"
Medex_00053042-RA	2	Reactome: R-HSA-2672351;Reactome: R-HSA-5578775	"Stimuli-sensing channels";"Ion homeostasis"
Medex_00099035-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00025201-RA	1	Reactome: R-HSA-1474228	"Degradation of the extracellular matrix"
Medex_00048318-RA	1	Reactome: R-HSA-912446	"Meiotic recombination"
Medex_00092381-RA	9	Reactome: R-HSA-68949;Reactome: R-HSA-68867;Reactome: R-HSA-69205;Reactome: R-HSA-68616;Reactome: R-HSA-68827;Reactome: R-HSA-176187;Reactome: R-HSA-68689;Reactome: R-HSA-113507;Reactome: R-HSA-68962	"Orc1 removal from chromatin";"Assembly of the pre-replicative complex";"G1/S-Specific Transcription";"Assembly of the ORC complex at the origin of replication";"CDT1 association with the CDC6:ORC:origin complex";"Activation of ATR in response to replication stress";"CDC6 association with the ORC:origin complex";"E2F-enabled inhibition of pre-replication complex formation";"Activation of the pre-replicative complex"
Medex_00039370-RA	2	Reactome: R-HSA-8951664;Reactome: R-HSA-983168	"Neddylation";"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00009071-RA	7	KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1	"Human cytomegalovirus infection";"Relaxin signaling pathway";"Thermogenesis";"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection"
Medex_00006239-RA	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
Medex_00091283-RA	13	Reactome: R-HSA-975957;Reactome: R-HSA-192823;Reactome: R-HSA-1799339;Reactome: R-HSA-156902;Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-72706;Reactome: R-HSA-975956;Reactome: R-HSA-72764;Reactome: R-HSA-72689;Reactome: R-HSA-2408557;Reactome: R-HSA-6791226	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Viral mRNA Translation";"SRP-dependent cotranslational protein targeting to membrane";"Peptide chain elongation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Formation of a pool of free 40S subunits";"Selenocysteine synthesis";"Major pathway of rRNA processing in the nucleolus and cytosol"
Medex_00016003-RA	3	Reactome: R-HSA-5620916;Reactome: R-HSA-264876;Reactome: R-HSA-1445148	"VxPx cargo-targeting to cilium";"Insulin processing";"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
Medex_00056473-RA	10	Reactome: R-HSA-9022538;Reactome: R-HSA-400206;Reactome: R-HSA-8936459;Reactome: R-HSA-427413;Reactome: R-HSA-3899300;Reactome: R-HSA-983231;Reactome: R-HSA-9022699;Reactome: R-HSA-9022702;Reactome: R-HSA-9615017;Reactome: R-HSA-9022692	"Loss of MECP2 binding ability to 5mC-DNA";"Regulation of lipid metabolism by PPARalpha";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"NoRC negatively regulates rRNA expression";"SUMOylation of transcription cofactors";"Factors involved in megakaryocyte development and platelet production";"MECP2 regulates neuronal receptors and channels";"MECP2 regulates transcription of neuronal ligands";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"Regulation of MECP2 expression and activity"
Medex_00071994-RA	5	Reactome: R-HSA-72163;Reactome: R-HSA-77595;Reactome: R-HSA-73856;Reactome: R-HSA-72187;Reactome: R-HSA-6784531	"mRNA Splicing - Major Pathway";"Processing of Intronless Pre-mRNAs";"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing";"tRNA processing in the nucleus"
Medex_00067565-RA	5	Reactome: R-HSA-69473;Reactome: R-HSA-5693607;Reactome: R-HSA-5689901;Reactome: R-HSA-5693571;Reactome: R-HSA-5693565	"G2/M DNA damage checkpoint";"Processing of DNA double-strand break ends";"Metalloprotease DUBs";"Nonhomologous End-Joining (NHEJ)";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"
Medex_00021581-RA	6	MetaCyc: PWY-6122;MetaCyc: PWY-6277;MetaCyc: PWY-6121;KEGG: 00230+6.3.4.13;Reactome: R-HSA-196780;Reactome: R-HSA-73817	"5-aminoimidazole ribonucleotide biosynthesis II";"Superpathway of 5-aminoimidazole ribonucleotide biosynthesis";"5-aminoimidazole ribonucleotide biosynthesis I";"Purine metabolism";"Biotin transport and metabolism";"Purine ribonucleoside monophosphate biosynthesis"
Medex_00052779-RA	2	Reactome: R-HSA-3299685;KEGG: 00480+1.11.1.15	"Detoxification of Reactive Oxygen Species";"Glutathione metabolism"
Medex_00058752-RA	6	MetaCyc: PWY-7039;Reactome: R-HSA-114508;KEGG: 04070+2.7.1.107;MetaCyc: PWY-7817;KEGG: 00561+2.7.1.107;KEGG: 00564+2.7.1.107	"Phosphatidate metabolism, as a signaling molecule";"Effects of PIP2 hydrolysis";"Phosphatidylinositol signaling system";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Glycerolipid metabolism";"Glycerophospholipid metabolism"
Medex_00021776-RA	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
Medex_00040277-RA	6	KEGG: 00564+2.7.1.107;KEGG: 04070+2.7.1.107;MetaCyc: PWY-7817;KEGG: 00561+2.7.1.107;Reactome: R-HSA-114508;MetaCyc: PWY-7039	"Glycerophospholipid metabolism";"Phosphatidylinositol signaling system";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Glycerolipid metabolism";"Effects of PIP2 hydrolysis";"Phosphatidate metabolism, as a signaling molecule"
Medex_00029190-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00012136-RA	1	Reactome: R-HSA-8951664	"Neddylation"
Medex_00004621-RA	7	KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1	"Human cytomegalovirus infection";"Thermogenesis";"Relaxin signaling pathway";"Human papillomavirus infection";"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection"
Medex_00005587-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Medex_00006537-RA	2	Reactome: R-HSA-383280;Reactome: R-HSA-4090294	"Nuclear Receptor transcription pathway";"SUMOylation of intracellular receptors"
Medex_00080134-RA	1	Reactome: R-HSA-6787639	"GDP-fucose biosynthesis"
Medex_00014137-RA	3	Reactome: R-HSA-5689880;Reactome: R-HSA-3214847;Reactome: R-HSA-201722	"Ub-specific processing proteases";"HATs acetylate histones";"Formation of the beta-catenin:TCF transactivating complex"
Medex_00023688-RA	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
Medex_00083783-RA	6	Reactome: R-HSA-72706;Reactome: R-HSA-72689;Reactome: R-HSA-72702;Reactome: R-HSA-72649;Reactome: R-HSA-156827;Reactome: R-HSA-72695	"GTP hydrolysis and joining of the 60S ribosomal subunit";"Formation of a pool of free 40S subunits";"Ribosomal scanning and start codon recognition";"Translation initiation complex formation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Formation of the ternary complex, and subsequently, the 43S complex"
Medex_00021890-RA	1	KEGG: 00970+6.1.1.20	"Aminoacyl-tRNA biosynthesis"
Medex_00035333-RA	7	Reactome: R-HSA-8854518;Reactome: R-HSA-380270;Reactome: R-HSA-380320;Reactome: R-HSA-2565942;Reactome: R-HSA-380259;Reactome: R-HSA-380284;Reactome: R-HSA-5620912	"AURKA Activation by TPX2";"Recruitment of mitotic centrosome proteins and complexes";"Recruitment of NuMA to mitotic centrosomes";"Regulation of PLK1 Activity at G2/M Transition";"Loss of Nlp from mitotic centrosomes";"Loss of proteins required for interphase microtubule organization from the centrosome";"Anchoring of the basal body to the plasma membrane"
Medex_00006586-RA	27	Reactome: R-HSA-168276;Reactome: R-HSA-5578749;Reactome: R-HSA-3371453;Reactome: R-HSA-159230;Reactome: R-HSA-4615885;Reactome: R-HSA-159227;Reactome: R-HSA-180746;Reactome: R-HSA-159231;Reactome: R-HSA-165054;Reactome: R-HSA-168333;Reactome: R-HSA-1169408;Reactome: R-HSA-191859;Reactome: R-HSA-159236;Reactome: R-HSA-168325;Reactome: R-HSA-6784531;Reactome: R-HSA-3108214;Reactome: R-HSA-9609690;Reactome: R-HSA-4551638;Reactome: R-HSA-9610379;Reactome: R-HSA-5619107;Reactome: R-HSA-4570464;Reactome: R-HSA-170822;Reactome: R-HSA-4085377;Reactome: R-HSA-3301854;Reactome: R-HSA-3232142;Reactome: R-HSA-180910;Reactome: R-HSA-168271	"NS1 Mediated Effects on Host Pathways";"Transcriptional regulation by small RNAs";"Regulation of HSF1-mediated heat shock response";"Transport of the SLBP Dependant Mature mRNA";"SUMOylation of DNA replication proteins";"Transport of the SLBP independent Mature mRNA";"Nuclear import of Rev protein";"Transport of Mature mRNA Derived from an Intronless Transcript";"Rev-mediated nuclear export of HIV RNA";"NEP/NS2 Interacts with the Cellular Export Machinery";"ISG15 antiviral mechanism";"snRNP Assembly";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Viral Messenger RNA Synthesis";"tRNA processing in the nucleus";"SUMOylation of DNA damage response and repair proteins";"HCMV Early Events";"SUMOylation of chromatin organization proteins";"HCMV Late Events";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"SUMOylation of RNA binding proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"SUMOylation of SUMOylation proteins";"Nuclear Pore Complex (NPC) Disassembly";"SUMOylation of ubiquitinylation proteins";"Vpr-mediated nuclear import of PICs";"Transport of Ribonucleoproteins into the Host Nucleus"
Medex_00057231-RA	4	Reactome: R-HSA-2470946;Reactome: R-HSA-2467813;Reactome: R-HSA-2468052;Reactome: R-HSA-2500257	"Cohesin Loading onto Chromatin";"Separation of Sister Chromatids";"Establishment of Sister Chromatid Cohesion";"Resolution of Sister Chromatid Cohesion"
Medex_00008359-RA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Medex_00089053-RA	13	MetaCyc: PWY-7226;MetaCyc: PWY-7227;Reactome: R-HSA-499943;MetaCyc: PWY-7198;MetaCyc: PWY-6545;MetaCyc: PWY-7222;KEGG: 00230+1.17.4.1;MetaCyc: PWY-7220;KEGG: 00480+1.17.4.1;MetaCyc: PWY-7184;KEGG: 00240+1.17.4.1;MetaCyc: PWY-7210;KEGG: 00983+1.17.4.1	"Guanosine deoxyribonucleotides de novo biosynthesis I";"Adenosine deoxyribonucleotides de novo biosynthesis";"Interconversion of nucleotide di- and triphosphates";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Guanosine deoxyribonucleotides de novo biosynthesis II";"Purine metabolism";"Adenosine deoxyribonucleotides de novo biosynthesis II";"Glutathione metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Pyrimidine metabolism";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Drug metabolism - other enzymes"
Medex_00041686-RA	3	Reactome: R-HSA-4090294;Reactome: R-HSA-3899300;Reactome: R-HSA-3232118	"SUMOylation of intracellular receptors";"SUMOylation of transcription cofactors";"SUMOylation of transcription factors"
Medex_00011312-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Medex_00103495-RA	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
Medex_00006250-RA	1	Reactome: R-HSA-8951664	"Neddylation"
Medex_00096371-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00015435-RA	3	KEGG: 04070+2.7.4.24+2.7.4.21;Reactome: R-HSA-1855167;MetaCyc: PWY-6369	"Phosphatidylinositol signaling system";"Synthesis of pyrophosphates in the cytosol";"Inositol diphosphates biosynthesis"
Medex_00048801-RA	9	KEGG: 00603+3.2.1.52;MetaCyc: PWY-6902;MetaCyc: PWY-7883;KEGG: 00531+3.2.1.52;KEGG: 00520+3.2.1.52;MetaCyc: PWY-7822;KEGG: 00513+3.2.1.52;KEGG: 00511+3.2.1.52;KEGG: 00604+3.2.1.52	"Glycosphingolipid biosynthesis - globo and isoglobo series";"Chitin degradation II (Vibrio)";"Anhydromuropeptides recycling II";"Glycosaminoglycan degradation";"Amino sugar and nucleotide sugar metabolism";"Chitin degradation III (Serratia)";"Various types of N-glycan biosynthesis";"Other glycan degradation";"Glycosphingolipid biosynthesis - ganglio series"
Medex_00035991-RA	1	Reactome: R-HSA-5685939	"HDR through MMEJ (alt-NHEJ)"
Medex_00065787-RA	2	Reactome: R-HSA-3769402;Reactome: R-HSA-201722	"Deactivation of the beta-catenin transactivating complex";"Formation of the beta-catenin:TCF transactivating complex"
Medex_00078568-RA	1	Reactome: R-HSA-216083	"Integrin cell surface interactions"
Medex_00062529-RA	2	MetaCyc: PWY-4261;KEGG: 00561+2.7.1.30	"Glycerol degradation I";"Glycerolipid metabolism"
Medex_00044291-RA	2	Reactome: R-HSA-1483148;Reactome: R-HSA-1483166	"Synthesis of PG";"Synthesis of PA"
Medex_00055487-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00024253-RA	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
Medex_00032414-RA	7	KEGG: 04070+3.1.4.11;MetaCyc: PWY-8052;MetaCyc: PWY-6367;KEGG: 00562+3.1.4.11;Reactome: R-HSA-1855204;MetaCyc: PWY-6351;MetaCyc: PWY-7039	"Phosphatidylinositol signaling system";"2-arachidonoylglycerol biosynthesis";"D-myo-inositol-5-phosphate metabolism";"Inositol phosphate metabolism";"Synthesis of IP3 and IP4 in the cytosol";"D-myo-inositol (1,4,5)-trisphosphate biosynthesis";"Phosphatidate metabolism, as a signaling molecule"
Medex_00087798-RA	26	Reactome: R-HSA-8852276;Reactome: R-HSA-983189;Reactome: R-HSA-9609736;Reactome: R-HSA-5626467;Reactome: R-HSA-2132295;Reactome: R-HSA-6807878;Reactome: R-HSA-190840;Reactome: R-HSA-190861;Reactome: R-HSA-437239;Reactome: R-HSA-9619483;Reactome: R-HSA-8955332;Reactome: R-HSA-9609690;Reactome: R-HSA-6811436;Reactome: R-HSA-9648025;Reactome: R-HSA-6811434;Reactome: R-HSA-68877;Reactome: R-HSA-389977;Reactome: R-HSA-2467813;Reactome: R-HSA-9646399;Reactome: R-HSA-5617833;Reactome: R-HSA-380320;Reactome: R-HSA-2500257;Reactome: R-HSA-3371497;Reactome: R-HSA-5663220;Reactome: R-HSA-389960;Reactome: R-HSA-1445148	"The role of GTSE1 in G2/M progression after G2 checkpoint";"Kinesins";"Assembly and cell surface presentation of NMDA receptors";"RHO GTPases activate IQGAPs";"MHC class II antigen presentation";"COPI-mediated anterograde transport";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Gap junction assembly";"Recycling pathway of L1";"Activation of AMPK downstream of NMDARs";"Carboxyterminal post-translational modifications of tubulin";"HCMV Early Events";"COPI-independent Golgi-to-ER retrograde traffic";"EML4 and NUDC in mitotic spindle formation";"COPI-dependent Golgi-to-ER retrograde traffic";"Mitotic Prometaphase";"Post-chaperonin tubulin folding pathway";"Separation of Sister Chromatids";"Aggrephagy";"Cilium Assembly";"Recruitment of NuMA to mitotic centrosomes";"Resolution of Sister Chromatid Cohesion";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"RHO GTPases Activate Formins";"Formation of tubulin folding intermediates by CCT/TriC";"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
Medex_00034426-RA	5	Reactome: R-HSA-917977;Reactome: R-HSA-1222556;Reactome: R-HSA-9639288;Reactome: R-HSA-77387;Reactome: R-HSA-983712	"Transferrin endocytosis and recycling";"ROS and RNS production in phagocytes";"Amino acids regulate mTORC1";"Insulin receptor recycling";"Ion channel transport"
Medex_00001827-RA	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
Medex_00039551-RA	24	Reactome: R-HSA-392451;Reactome: R-HSA-202040;Reactome: R-HSA-432040;Reactome: R-HSA-392851;Reactome: R-HSA-400042;Reactome: R-HSA-9009391;Reactome: R-HSA-420092;Reactome: R-HSA-418592;Reactome: R-HSA-428930;Reactome: R-HSA-6814122;Reactome: R-HSA-418594;Reactome: R-HSA-416476;Reactome: R-HSA-418597;Reactome: R-HSA-456926;Reactome: R-HSA-392170;Reactome: R-HSA-8964616;Reactome: R-HSA-500657;Reactome: R-HSA-418217;Reactome: R-HSA-4086398;Reactome: R-HSA-163359;Reactome: R-HSA-418555;Reactome: R-HSA-416482;Reactome: R-HSA-381676;Reactome: R-HSA-8964315	"G beta:gamma signalling through PI3Kgamma";"G-protein activation";"Vasopressin regulates renal water homeostasis via Aquaporins";"Prostacyclin signalling through prostacyclin receptor";"Adrenaline,noradrenaline inhibits insulin secretion";"Extra-nuclear estrogen signaling";"Glucagon-type ligand receptors";"ADP signalling through P2Y purinoceptor 1";"Thromboxane signalling through TP receptor";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"G alpha (i) signalling events";"G alpha (q) signalling events";"G alpha (z) signalling events";"Thrombin signalling through proteinase activated receptors (PARs)";"ADP signalling through P2Y purinoceptor 12";"G beta:gamma signalling through CDC42";"Presynaptic function of Kainate receptors";"G beta:gamma signalling through PLC beta";"Ca2+ pathway";"Glucagon signaling in metabolic regulation";"G alpha (s) signalling events";"G alpha (12/13) signalling events";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"G beta:gamma signalling through BTK"
Medex_00016289-RA	6	Reactome: R-HSA-8866654;Reactome: R-HSA-75955;Reactome: R-HSA-5632684;Reactome: R-HSA-112382;Reactome: R-HSA-674695;Reactome: R-HSA-201722	"E3 ubiquitin ligases ubiquitinate target proteins";"RNA Polymerase II Transcription Elongation";"Hedgehog 'on' state";"Formation of RNA Pol II elongation complex";"RNA Polymerase II Pre-transcription Events";"Formation of the beta-catenin:TCF transactivating complex"
Medex_00016203-RA	1	Reactome: R-HSA-420499	"Class C/3 (Metabotropic glutamate/pheromone receptors)"
Medex_00050848-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00076130-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Medex_00078201-RA	6	KEGG: 00531+3.2.1.23;KEGG: 00052+3.2.1.23;KEGG: 00600+3.2.1.23;KEGG: 00511+3.2.1.23;MetaCyc: PWY-6807;KEGG: 00604+3.2.1.23	"Glycosaminoglycan degradation";"Galactose metabolism";"Sphingolipid metabolism";"Other glycan degradation";"Xyloglucan degradation II (exoglucanase)";"Glycosphingolipid biosynthesis - ganglio series"
Medex_00011396-RA	7	KEGG: 00620+2.3.3.9;MetaCyc: PWY-7118;MetaCyc: PWY-6969;KEGG: 00630+2.3.3.9;MetaCyc: PWY-7295;MetaCyc: PWY-7854;MetaCyc: PWY-7294	"Pyruvate metabolism";"Chitin degradation to ethanol";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Glyoxylate and dicarboxylate metabolism";"L-arabinose degradation IV";"Crotonyl-coa/ethylmalonyl-coa/hydroxybutyryl-coa cycle (engineered)";"D-xylose degradation IV"
Medex_00014479-RA	1	Reactome: R-HSA-114608	"Platelet degranulation"
Medex_00090825-RA	1	Reactome: R-HSA-425381	"Bicarbonate transporters"
Medex_00089836-RA	14	KEGG: 00062+2.3.1.199;MetaCyc: PWY-6598;MetaCyc: PWY-7725;MetaCyc: PWY-8041;MetaCyc: PWY-5080;MetaCyc: PWY-7601;MetaCyc: PWY-7724;MetaCyc: PWY-5972;MetaCyc: PWY-7035;Reactome: R-HSA-75876;MetaCyc: PWY-6433;MetaCyc: PWY-7036;MetaCyc: PWY-7619;MetaCyc: PWY-7602	"Fatty acid elongation";"Sciadonate biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Ultra-long-chain fatty acid biosynthesis";"Very long chain fatty acid biosynthesis I";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Stearate biosynthesis I (animals)";"(9Z)-tricosene biosynthesis";"Synthesis of very long-chain fatty acyl-CoAs";"Hydroxylated fatty acid biosynthesis (plants)";"Very long chain fatty acid biosynthesis II";"Juniperonate biosynthesis";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)"
Medex_00036025-RA	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
Medex_00026910-RA	9	Reactome: R-HSA-5693607;Reactome: R-HSA-5685938;Reactome: R-HSA-5685942;Reactome: R-HSA-5693554;Reactome: R-HSA-5693616;Reactome: R-HSA-69473;Reactome: R-HSA-6804756;Reactome: R-HSA-5693579;Reactome: R-HSA-5693568	"Processing of DNA double-strand break ends";"HDR through Single Strand Annealing (SSA)";"HDR through Homologous Recombination (HRR)";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Presynaptic phase of homologous DNA pairing and strand exchange";"G2/M DNA damage checkpoint";"Regulation of TP53 Activity through Phosphorylation";"Homologous DNA Pairing and Strand Exchange";"Resolution of D-loop Structures through Holliday Junction Intermediates"
Medex_00075093-RA	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00077084-RA	8	Reactome: R-HSA-68962;Reactome: R-HSA-113501;Reactome: R-HSA-69183;Reactome: R-HSA-174411;Reactome: R-HSA-69091;Reactome: R-HSA-68952;Reactome: R-HSA-174430;Reactome: R-HSA-69166	"Activation of the pre-replicative complex";"Inhibition of replication initiation of damaged DNA by RB1/E2F1";"Processive synthesis on the lagging strand";"Polymerase switching on the C-strand of the telomere";"Polymerase switching";"DNA replication initiation";"Telomere C-strand synthesis initiation";"Removal of the Flap Intermediate"
Medex_00064348-RA	1	Reactome: R-HSA-1632852	"Macroautophagy"
Medex_00088234-RA	2	Reactome: R-HSA-8936459;Reactome: R-HSA-3214841	"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"PKMTs methylate histone lysines"
Medex_00004771-RA	1	Reactome: R-HSA-432722	"Golgi Associated Vesicle Biogenesis"
Medex_00081760-RA	3	Reactome: R-HSA-196807;Reactome: R-HSA-74259;Reactome: R-HSA-73621	"Nicotinate metabolism";"Purine catabolism";"Pyrimidine catabolism"
Medex_00005991-RA	6	Reactome: R-HSA-114508;MetaCyc: PWY-7039;KEGG: 00564+2.7.1.107;MetaCyc: PWY-7817;KEGG: 04070+2.7.1.107;KEGG: 00561+2.7.1.107	"Effects of PIP2 hydrolysis";"Phosphatidate metabolism, as a signaling molecule";"Glycerophospholipid metabolism";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Phosphatidylinositol signaling system";"Glycerolipid metabolism"
Medex_00018881-RA	1	Reactome: R-HSA-216083	"Integrin cell surface interactions"
Medex_00077227-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00038041-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Medex_00040954-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00022328-RA	1	Reactome: R-HSA-1474228	"Degradation of the extracellular matrix"
Medex_00002614-RA	6	KEGG: 00030+5.1.3.1;KEGG: 00710+5.1.3.1;MetaCyc: PWY-5723;KEGG: 00040+5.1.3.1;MetaCyc: PWY-1861;Reactome: R-HSA-71336	"Pentose phosphate pathway";"Carbon fixation in photosynthetic organisms";"Rubisco shunt";"Pentose and glucuronate interconversions";"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"Pentose phosphate pathway"
Medex_00072447-RA	3	Reactome: R-HSA-3000171;Reactome: R-HSA-8874081;Reactome: R-HSA-3000157	"Non-integrin membrane-ECM interactions";"MET activates PTK2 signaling";"Laminin interactions"
Medex_00017040-RA	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
Medex_00021736-RA	7	Reactome: R-HSA-2894862;Reactome: R-HSA-2691232;Reactome: R-HSA-2979096;MetaCyc: PWY-7511;Reactome: R-HSA-2122948;Reactome: R-HSA-9013507;Reactome: R-HSA-2644606	"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Constitutive Signaling by NOTCH1 HD Domain Mutants";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Protein ubiquitination";"Activated NOTCH1 Transmits Signal to the Nucleus";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Constitutive Signaling by NOTCH1 PEST Domain Mutants"
Medex_00007408-RA	4	Reactome: R-HSA-917977;Reactome: R-HSA-983712;Reactome: R-HSA-77387;Reactome: R-HSA-1222556	"Transferrin endocytosis and recycling";"Ion channel transport";"Insulin receptor recycling";"ROS and RNS production in phagocytes"
Medex_00043641-RA	2	Reactome: R-HSA-444821;Reactome: R-HSA-418555	"Relaxin receptors";"G alpha (s) signalling events"
Medex_00087130-RA	2	Reactome: R-HSA-381340;Reactome: R-HSA-1989781	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression"
Medex_00039544-RA	8	MetaCyc: PWY-7921;KEGG: 00515+2.4.1.109;Reactome: R-HSA-5083633;Reactome: R-HSA-5083629;Reactome: R-HSA-5173105;MetaCyc: PWY-7922;KEGG: 00514+2.4.1.109;MetaCyc: PWY-7979	"Protein O-mannosylation I (yeast)";"Mannose type O-glycan biosynthesis";"Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1";"Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2";"O-linked glycosylation";"Protein O-mannosylation II (mammals, core M1 and core M2)";"Other types of O-glycan biosynthesis";"Protein O-mannosylation III (mammals, core M3)"
Medex_00007217-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Medex_00069026-RA	3	Reactome: R-HSA-193648;Reactome: R-HSA-194840;Reactome: R-HSA-416482	"NRAGE signals death through JNK";"Rho GTPase cycle";"G alpha (12/13) signalling events"
Medex_00074848-RA	3	Reactome: R-HSA-3214858;Reactome: R-HSA-191859;Reactome: R-HSA-6804760	"RMTs methylate histone arginines";"snRNP Assembly";"Regulation of TP53 Activity through Methylation"
Medex_00007176-RA	1	Reactome: R-HSA-6798163	"Choline catabolism"
Medex_00022927-RA	1	Reactome: R-HSA-3238698	"WNT ligand biogenesis and trafficking"
Medex_00048248-RA	2	Reactome: R-HSA-8856825;Reactome: R-HSA-8856828	"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis"
Medex_00024943-RA	10	KEGG: 00710+5.3.1.1;KEGG: 00562+5.3.1.1;Reactome: R-HSA-70263;Reactome: R-HSA-70171;MetaCyc: PWY-1042;MetaCyc: PWY-6142;MetaCyc: PWY-7003;KEGG: 00051+5.3.1.1;KEGG: 00010+5.3.1.1;MetaCyc: PWY-5484	"Carbon fixation in photosynthetic organisms";"Inositol phosphate metabolism";"Gluconeogenesis";"Glycolysis";"Glycolysis IV (plant cytosol)";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Glycerol degradation to butanol";"Fructose and mannose metabolism";"Glycolysis / Gluconeogenesis";"Glycolysis II (from fructose 6-phosphate)"
Medex_00079101-RA	1	Reactome: R-HSA-9033241	"Peroxisomal protein import"
Medex_00061480-RA	6	Reactome: R-HSA-9640463;MetaCyc: PWY-5884;MetaCyc: PWY-7782;MetaCyc: PWY-6733;MetaCyc: PWY-7656;KEGG: 00073+1.2.1.84	"Wax biosynthesis";"Wax esters biosynthesis I";"Plasmalogen biosynthesis";"Sporopollenin precursors biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Cutin, suberine and wax biosynthesis"
Medex_00071175-RA	1	Reactome: R-HSA-1474228	"Degradation of the extracellular matrix"
Medex_00032070-RA	3	Reactome: R-HSA-1445148;Reactome: R-HSA-5620916;Reactome: R-HSA-264876	"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"VxPx cargo-targeting to cilium";"Insulin processing"
Medex_00048787-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Medex_00039274-RA	8	Reactome: R-HSA-380972;Reactome: R-HSA-1632852;Reactome: R-HSA-1445148;Reactome: R-HSA-5628897;Reactome: R-HSA-9619483;Reactome: R-HSA-2151209;Reactome: R-HSA-6804756;Reactome: R-HSA-9613354	"Energy dependent regulation of mTOR by LKB1-AMPK";"Macroautophagy";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"TP53 Regulates Metabolic Genes";"Activation of AMPK downstream of NMDARs";"Activation of PPARGC1A (PGC-1alpha) by phosphorylation";"Regulation of TP53 Activity through Phosphorylation";"Lipophagy"
Medex_00026087-RA	2	Reactome: R-HSA-5694530;Reactome: R-HSA-204005	"Cargo concentration in the ER";"COPII-mediated vesicle transport"
Medex_00038182-RA	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840	"Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation"
Medex_00041096-RA	9	Reactome: R-HSA-110329;Reactome: R-HSA-110331;Reactome: R-HSA-110328;Reactome: R-HSA-9656256;Reactome: R-HSA-9656255;Reactome: R-HSA-9657050;Reactome: R-HSA-110357;Reactome: R-HSA-5649702;Reactome: R-HSA-110330	"Cleavage of the damaged pyrimidine";"Cleavage of the damaged purine";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"Defective OGG1 Substrate Processing";"Defective OGG1 Substrate Binding";"Defective OGG1 Localization";"Displacement of DNA glycosylase by APEX1";"APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway";"Recognition and association of DNA glycosylase with site containing an affected purine"
Medex_00031226-RA	4	Reactome: R-HSA-5676590;Reactome: R-HSA-5607761;Reactome: R-HSA-8951664;Reactome: R-HSA-983168	"NIK-->noncanonical NF-kB signaling";"Dectin-1 mediated noncanonical NF-kB signaling";"Neddylation";"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00004448-RA	3	MetaCyc: PWY-6348;KEGG: 00730+3.1.3.2;KEGG: 00740+3.1.3.2	"Phosphate acquisition";"Thiamine metabolism";"Riboflavin metabolism"
Medex_00001178-RA	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00054261-RA	4	Reactome: R-HSA-2393930;KEGG: 00240+3.6.1.17;KEGG: 00230+3.6.1.17;Reactome: R-HSA-3299685	"Phosphate bond hydrolysis by NUDT proteins";"Pyrimidine metabolism";"Purine metabolism";"Detoxification of Reactive Oxygen Species"
Medex_00027150-RA	2	MetaCyc: PWY-6111;KEGG: 00071+2.3.1.21	"Mitochondrial L-carnitine shuttle";"Fatty acid degradation"
Medex_00068889-RA	5	Reactome: R-HSA-77387;Reactome: R-HSA-983712;Reactome: R-HSA-1222556;Reactome: R-HSA-9639288;Reactome: R-HSA-917977	"Insulin receptor recycling";"Ion channel transport";"ROS and RNS production in phagocytes";"Amino acids regulate mTORC1";"Transferrin endocytosis and recycling"
Medex_00047845-RA	3	Reactome: R-HSA-114608;Reactome: R-HSA-381426;Reactome: R-HSA-8957275	"Platelet degranulation";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"Post-translational protein phosphorylation"
Medex_00018192-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Medex_00043421-RA	10	MetaCyc: PWY-1042;Reactome: R-HSA-70171;KEGG: 00030+2.7.1.11;KEGG: 00680+2.7.1.11;MetaCyc: PWY-5484;MetaCyc: PWY-1861;KEGG: 00052+2.7.1.11;MetaCyc: PWY-7385;KEGG: 00051+2.7.1.11;KEGG: 00010+2.7.1.11	"Glycolysis IV (plant cytosol)";"Glycolysis";"Pentose phosphate pathway";"Methane metabolism";"Glycolysis II (from fructose 6-phosphate)";"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"Galactose metabolism";"1,3-propanediol biosynthesis (engineered)";"Fructose and mannose metabolism";"Glycolysis / Gluconeogenesis"
Medex_00043828-RA	5	Reactome: R-HSA-5689880;Reactome: R-HSA-201681;Reactome: R-HSA-8948751;Reactome: R-HSA-4641257;MetaCyc: PWY-7511	"Ub-specific processing proteases";"TCF dependent signaling in response to WNT";"Regulation of PTEN stability and activity";"Degradation of AXIN";"Protein ubiquitination"
Medex_00025997-RA	3	Reactome: R-HSA-110329;Reactome: R-HSA-110357;Reactome: R-HSA-110328	"Cleavage of the damaged pyrimidine";"Displacement of DNA glycosylase by APEX1";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine"
Medex_00063849-RA	4	MetaCyc: PWY-7221;Reactome: R-HSA-73817;KEGG: 00230+6.3.5.2;KEGG: 00983+6.3.5.2	"Guanosine ribonucleotides de novo biosynthesis";"Purine ribonucleoside monophosphate biosynthesis";"Purine metabolism";"Drug metabolism - other enzymes"
Medex_00007303-RA	1	Reactome: R-HSA-1660661	"Sphingolipid de novo biosynthesis"
Medex_00075618-RA	15	Reactome: R-HSA-2559585;Reactome: R-HSA-5628897;Reactome: R-HSA-1912408;Reactome: R-HSA-9018519;Reactome: R-HSA-5687128;Reactome: R-HSA-8934593;Reactome: R-HSA-8936459;Reactome: R-HSA-8986944;Reactome: R-HSA-2559580;Reactome: R-HSA-8943723;Reactome: R-HSA-8853884;Reactome: R-HSA-9022692;Reactome: R-HSA-8948700;Reactome: R-HSA-4086398;Reactome: R-HSA-9029569	"Oncogene Induced Senescence";"TP53 Regulates Metabolic Genes";"Pre-NOTCH Transcription and Translation";"Estrogen-dependent gene expression";"MAPK6/MAPK4 signaling";"Regulation of RUNX1 Expression and Activity";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Transcriptional Regulation by MECP2";"Oxidative Stress Induced Senescence";"Regulation of PTEN mRNA translation";"Transcriptional Regulation by VENTX";"Regulation of MECP2 expression and activity";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"Ca2+ pathway";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux"
Medex_00082879-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00045097-RA	1	Reactome: R-HSA-203927	"MicroRNA (miRNA) biogenesis"
Medex_00004065-RA	2	KEGG: 00500+3.2.1.4;MetaCyc: PWY-6788	"Starch and sucrose metabolism";"Cellulose degradation II (fungi)"
Medex_00007375-RA	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
Medex_00036174-RA	1	KEGG: 00290+4.2.1.33	"Valine, leucine and isoleucine biosynthesis"
Medex_00009785-RA	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
Medex_00064755-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Medex_00082278-RA	1	Reactome: R-HSA-6809371	"Formation of the cornified envelope"
Medex_00069072-RA	5	Reactome: R-HSA-390471;Reactome: R-HSA-390450;Reactome: R-HSA-389960;Reactome: R-HSA-6814122;Reactome: R-HSA-389957	"Association of TriC/CCT with target proteins during biosynthesis";"Folding of actin by CCT/TriC";"Formation of tubulin folding intermediates by CCT/TriC";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"Prefoldin mediated transfer of substrate to CCT/TriC"
Medex_00032324-RA	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
Medex_00056897-RA	1	Reactome: R-HSA-975957	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
Medex_00055931-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Medex_00036873-RA	1	Reactome: R-HSA-433137	"Sodium-coupled sulphate, di- and tri-carboxylate transporters"
Medex_00024121-RA	3	Reactome: R-HSA-193648;Reactome: R-HSA-416482;Reactome: R-HSA-194840	"NRAGE signals death through JNK";"G alpha (12/13) signalling events";"Rho GTPase cycle"
Medex_00092465-RA	3	Reactome: R-HSA-6804760;Reactome: R-HSA-2299718;Reactome: R-HSA-3214841	"Regulation of TP53 Activity through Methylation";"Condensation of Prophase Chromosomes";"PKMTs methylate histone lysines"
Medex_00074373-RA	1	Reactome: R-HSA-1660499	"Synthesis of PIPs at the plasma membrane"
Medex_00007404-RA	4	Reactome: R-HSA-1222556;Reactome: R-HSA-983712;Reactome: R-HSA-77387;Reactome: R-HSA-917977	"ROS and RNS production in phagocytes";"Ion channel transport";"Insulin receptor recycling";"Transferrin endocytosis and recycling"
Medex_00045235-RA	2	Reactome: R-HSA-6804115;Reactome: R-HSA-429947	"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Deadenylation of mRNA"
Medex_00093109-RA	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00043664-RA	1	KEGG: 00480+3.4.11.2	"Glutathione metabolism"
Medex_00006713-RA	8	KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;Reactome: R-HSA-6791226;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1	"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"mTOR signaling pathway";"Thermogenesis";"Major pathway of rRNA processing in the nucleolus and cytosol";"PI3K-Akt signaling pathway";"Relaxin signaling pathway";"Human cytomegalovirus infection"
Medex_00093845-RA	1	Reactome: R-HSA-209968	"Thyroxine biosynthesis"
Medex_00026504-RA	1	Reactome: R-HSA-6811438	"Intra-Golgi traffic"
Medex_00022551-RA	56	Reactome: R-HSA-8854050;Reactome: R-HSA-1236974;Reactome: R-HSA-5610783;Reactome: R-HSA-174084;Reactome: R-HSA-187577;Reactome: R-HSA-2871837;Reactome: R-HSA-8951664;Reactome: R-HSA-174184;Reactome: R-HSA-5607764;Reactome: R-HSA-174154;Reactome: R-HSA-1169091;Reactome: R-HSA-9604323;Reactome: R-HSA-8948751;Reactome: R-HSA-68827;Reactome: R-HSA-5676590;Reactome: R-HSA-1234176;Reactome: R-HSA-5362768;Reactome: R-HSA-69017;Reactome: R-HSA-69601;Reactome: R-HSA-4641257;Reactome: R-HSA-174113;Reactome: R-HSA-5678895;Reactome: R-HSA-350562;Reactome: R-HSA-69481;Reactome: R-HSA-68949;Reactome: R-HSA-8939236;Reactome: R-HSA-382556;Reactome: R-HSA-211733;Reactome: R-HSA-9010553;Reactome: R-HSA-450408;Reactome: R-HSA-180585;Reactome: R-HSA-2467813;Reactome: R-HSA-4641258;Reactome: R-HSA-9020702;Reactome: R-HSA-202424;Reactome: R-HSA-983168;Reactome: R-HSA-8941858;Reactome: R-HSA-5358346;Reactome: R-HSA-5658442;Reactome: R-HSA-174178;Reactome: R-HSA-5610780;Reactome: R-HSA-8852276;Reactome: R-HSA-5607761;Reactome: R-HSA-180534;Reactome: R-HSA-1236978;Reactome: R-HSA-349425;Reactome: R-HSA-5632684;Reactome: R-HSA-4608870;Reactome: R-HSA-5668541;Reactome: R-HSA-5689603;Reactome: R-HSA-5687128;Reactome: R-HSA-5610785;Reactome: R-HSA-5689880;Reactome: R-HSA-195253;Reactome: R-HSA-75815;Reactome: R-HSA-8939902	"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"ER-Phagosome pathway";"Degradation of GLI2 by the proteasome";"Autodegradation of Cdh1 by Cdh1:APC/C";"SCF(Skp2)-mediated degradation of p27/p21";"FCERI mediated NF-kB activation";"Neddylation";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"CLEC7A (Dectin-1) signaling";"APC/C:Cdc20 mediated degradation of Securin";"Activation of NF-kappaB in B cells";"Negative regulation of NOTCH4 signaling";"Regulation of PTEN stability and activity";"CDT1 association with the CDC6:ORC:origin complex";"NIK-->noncanonical NF-kB signaling";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"CDK-mediated phosphorylation and removal of Cdc6";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Degradation of AXIN";"SCF-beta-TrCP mediated degradation of Emi1";"Defective CFTR causes cystic fibrosis";"Regulation of ornithine decarboxylase (ODC)";"G2/M Checkpoints";"Orc1 removal from chromatin";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"ABC-family proteins mediated transport";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Regulation of expression of SLITs and ROBOs";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Vif-mediated degradation of APOBEC3G";"Separation of Sister Chromatids";"Degradation of DVL";"Interleukin-1 signaling";"Downstream TCR signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Regulation of RUNX3 expression and activity";"Hedgehog ligand biogenesis";"Regulation of RAS by GAPs";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Degradation of GLI1 by the proteasome";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Dectin-1 mediated noncanonical NF-kB signaling";"Vpu mediated degradation of CD4";"Cross-presentation of soluble exogenous antigens (endosomes)";"Autodegradation of the E3 ubiquitin ligase COP1";"Hedgehog 'on' state";"Asymmetric localization of PCP proteins";"TNFR2 non-canonical NF-kB pathway";"UCH proteinases";"MAPK6/MAPK4 signaling";"GLI3 is processed to GLI3R by the proteasome";"Ub-specific processing proteases";"Degradation of beta-catenin by the destruction complex";"Ubiquitin-dependent degradation of Cyclin D";"Regulation of RUNX2 expression and activity"
Medex_00018792-RA	52	Reactome: R-HSA-8939902;Reactome: R-HSA-75815;Reactome: R-HSA-195253;Reactome: R-HSA-5689880;Reactome: R-HSA-5610785;Reactome: R-HSA-5689603;Reactome: R-HSA-5687128;Reactome: R-HSA-5668541;Reactome: R-HSA-4608870;Reactome: R-HSA-5632684;Reactome: R-HSA-1236978;Reactome: R-HSA-349425;Reactome: R-HSA-180534;Reactome: R-HSA-5607761;Reactome: R-HSA-5610780;Reactome: R-HSA-8852276;Reactome: R-HSA-174178;Reactome: R-HSA-5658442;Reactome: R-HSA-5358346;Reactome: R-HSA-983168;Reactome: R-HSA-202424;Reactome: R-HSA-9020702;Reactome: R-HSA-4641258;Reactome: R-HSA-2467813;Reactome: R-HSA-180585;Reactome: R-HSA-450408;Reactome: R-HSA-9010553;Reactome: R-HSA-8939236;Reactome: R-HSA-68949;Reactome: R-HSA-382556;Reactome: R-HSA-211733;Reactome: R-HSA-5678895;Reactome: R-HSA-350562;Reactome: R-HSA-69481;Reactome: R-HSA-174113;Reactome: R-HSA-4641257;Reactome: R-HSA-69601;Reactome: R-HSA-69017;Reactome: R-HSA-5362768;Reactome: R-HSA-1234176;Reactome: R-HSA-5676590;Reactome: R-HSA-68827;Reactome: R-HSA-8948751;Reactome: R-HSA-1169091;Reactome: R-HSA-174154;Reactome: R-HSA-5607764;Reactome: R-HSA-174184;Reactome: R-HSA-8951664;Reactome: R-HSA-2871837;Reactome: R-HSA-5610783;Reactome: R-HSA-1236974;Reactome: R-HSA-8854050	"Regulation of RUNX2 expression and activity";"Ubiquitin-dependent degradation of Cyclin D";"Degradation of beta-catenin by the destruction complex";"Ub-specific processing proteases";"GLI3 is processed to GLI3R by the proteasome";"UCH proteinases";"MAPK6/MAPK4 signaling";"TNFR2 non-canonical NF-kB pathway";"Asymmetric localization of PCP proteins";"Hedgehog 'on' state";"Cross-presentation of soluble exogenous antigens (endosomes)";"Autodegradation of the E3 ubiquitin ligase COP1";"Vpu mediated degradation of CD4";"Dectin-1 mediated noncanonical NF-kB signaling";"Degradation of GLI1 by the proteasome";"The role of GTSE1 in G2/M progression after G2 checkpoint";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Regulation of RAS by GAPs";"Hedgehog ligand biogenesis";"Antigen processing: Ubiquitination & Proteasome degradation";"Downstream TCR signaling";"Interleukin-1 signaling";"Degradation of DVL";"Separation of Sister Chromatids";"Vif-mediated degradation of APOBEC3G";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Regulation of expression of SLITs and ROBOs";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Orc1 removal from chromatin";"ABC-family proteins mediated transport";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Defective CFTR causes cystic fibrosis";"Regulation of ornithine decarboxylase (ODC)";"G2/M Checkpoints";"SCF-beta-TrCP mediated degradation of Emi1";"Degradation of AXIN";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"CDK-mediated phosphorylation and removal of Cdc6";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"NIK-->noncanonical NF-kB signaling";"CDT1 association with the CDC6:ORC:origin complex";"Regulation of PTEN stability and activity";"Activation of NF-kappaB in B cells";"APC/C:Cdc20 mediated degradation of Securin";"CLEC7A (Dectin-1) signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Neddylation";"FCERI mediated NF-kB activation";"Degradation of GLI2 by the proteasome";"ER-Phagosome pathway";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis"
Medex_00006160-RA	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
Medex_00062596-RA	3	Reactome: R-HSA-4420097;Reactome: R-HSA-2029482;Reactome: R-HSA-5663213	"VEGFA-VEGFR2 Pathway";"Regulation of actin dynamics for phagocytic cup formation";"RHO GTPases Activate WASPs and WAVEs"
Medex_00007795-RA	25	Reactome: R-HSA-8939236;Reactome: R-HSA-8939243;Reactome: R-HSA-8939245;Reactome: R-HSA-8878166;Reactome: R-HSA-8951936;Reactome: R-HSA-8939242;Reactome: R-HSA-8877330;Reactome: R-HSA-8941284;Reactome: R-HSA-8939247;Reactome: R-HSA-8936459;Reactome: R-HSA-8951911;Reactome: R-HSA-8941858;Reactome: R-HSA-9018519;Reactome: R-HSA-8940973;Reactome: R-HSA-8949275;Reactome: R-HSA-8941326;Reactome: R-HSA-8935964;Reactome: R-HSA-8931987;Reactome: R-HSA-8939246;Reactome: R-HSA-8941332;Reactome: R-HSA-8934593;Reactome: R-HSA-8939902;Reactome: R-HSA-8941333;Reactome: R-HSA-8939256;Reactome: R-HSA-9616222	"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RUNX1 regulates transcription of genes involved in BCR signaling";"Transcriptional regulation by RUNX2";"RUNX3 regulates p14-ARF";"RUNX1 regulates transcription of genes involved in differentiation of keratinocytes";"RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)";"RUNX2 regulates chondrocyte maturation";"RUNX1 regulates transcription of genes involved in interleukin signaling";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"RUNX3 regulates RUNX1-mediated transcription";"Regulation of RUNX3 expression and activity";"Estrogen-dependent gene expression";"RUNX2 regulates osteoblast differentiation";"RUNX3 Regulates Immune Response and Cell Migration";"RUNX2 regulates bone development";"RUNX1 regulates expression of components of tight junctions";"RUNX1 regulates estrogen receptor mediated transcription";"RUNX1 regulates transcription of genes involved in differentiation of myeloid cells";"RUNX2 regulates genes involved in cell migration";"Regulation of RUNX1 Expression and Activity";"Regulation of RUNX2 expression and activity";"RUNX2 regulates genes involved in differentiation of myeloid cells";"RUNX1 regulates transcription of genes involved in WNT signaling";"Transcriptional regulation of granulopoiesis"
Medex_00070540-RA	1	Reactome: R-HSA-3214858	"RMTs methylate histone arginines"
Medex_00010711-RA	9	Reactome: R-HSA-2022928;Reactome: R-HSA-2024096;Reactome: R-HSA-3560783;Reactome: R-HSA-3560801;Reactome: R-HSA-975634;Reactome: R-HSA-3656253;Reactome: R-HSA-4420332;Reactome: R-HSA-3656237;Reactome: R-HSA-1971475	"HS-GAG biosynthesis";"HS-GAG degradation";"Defective B4GALT7 causes EDS, progeroid type";"Defective B3GAT3 causes JDSSDHD";"Retinoid metabolism and transport";"Defective EXT1 causes exostoses 1, TRPS2 and CHDS";"Defective B3GALT6 causes EDSP2 and SEMDJL1";"Defective EXT2 causes exostoses 2";"A tetrasaccharide linker sequence is required for GAG synthesis"
Medex_00089121-RA	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
Medex_00091857-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00034782-RA	10	Reactome: R-HSA-2132295;Reactome: R-HSA-432720;Reactome: R-HSA-203641;Reactome: R-HSA-8856828;Reactome: R-HSA-190873;Reactome: R-HSA-437239;Reactome: R-HSA-196025;Reactome: R-HSA-432722;Reactome: R-HSA-177504;Reactome: R-HSA-166016	"MHC class II antigen presentation";"Lysosome Vesicle Biogenesis";"NOSTRIN mediated eNOS trafficking";"Clathrin-mediated endocytosis";"Gap junction degradation";"Recycling pathway of L1";"Formation of annular gap junctions";"Golgi Associated Vesicle Biogenesis";"Retrograde neurotrophin signalling";"Toll Like Receptor 4 (TLR4) Cascade"
Medex_00048130-RA	2	Reactome: R-HSA-432720;Reactome: R-HSA-432722	"Lysosome Vesicle Biogenesis";"Golgi Associated Vesicle Biogenesis"
Medex_00002107-RA	24	Reactome: R-HSA-418217;Reactome: R-HSA-4086398;Reactome: R-HSA-163359;Reactome: R-HSA-418555;Reactome: R-HSA-416482;Reactome: R-HSA-381676;Reactome: R-HSA-8964315;Reactome: R-HSA-416476;Reactome: R-HSA-418594;Reactome: R-HSA-418597;Reactome: R-HSA-456926;Reactome: R-HSA-392170;Reactome: R-HSA-8964616;Reactome: R-HSA-500657;Reactome: R-HSA-9009391;Reactome: R-HSA-420092;Reactome: R-HSA-418592;Reactome: R-HSA-428930;Reactome: R-HSA-6814122;Reactome: R-HSA-392451;Reactome: R-HSA-432040;Reactome: R-HSA-202040;Reactome: R-HSA-392851;Reactome: R-HSA-400042	"G beta:gamma signalling through PLC beta";"Ca2+ pathway";"Glucagon signaling in metabolic regulation";"G alpha (s) signalling events";"G alpha (12/13) signalling events";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"G beta:gamma signalling through BTK";"G alpha (q) signalling events";"G alpha (i) signalling events";"G alpha (z) signalling events";"Thrombin signalling through proteinase activated receptors (PARs)";"ADP signalling through P2Y purinoceptor 12";"G beta:gamma signalling through CDC42";"Presynaptic function of Kainate receptors";"Extra-nuclear estrogen signaling";"Glucagon-type ligand receptors";"ADP signalling through P2Y purinoceptor 1";"Thromboxane signalling through TP receptor";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"G beta:gamma signalling through PI3Kgamma";"Vasopressin regulates renal water homeostasis via Aquaporins";"G-protein activation";"Prostacyclin signalling through prostacyclin receptor";"Adrenaline,noradrenaline inhibits insulin secretion"
Medex_00074120-RA	4	Reactome: R-HSA-8856828;Reactome: R-HSA-5250958;Reactome: R-HSA-8856825;Reactome: R-HSA-6794361	"Clathrin-mediated endocytosis";"Toxicity of botulinum toxin type B (BoNT/B)";"Cargo recognition for clathrin-mediated endocytosis";"Neurexins and neuroligins"
Medex_00034928-RA	4	Reactome: R-HSA-156581;MetaCyc: PWY-5912;KEGG: 00270+2.5.1.6;MetaCyc: PWY-5041	"Methylation";"2'-deoxymugineic acid phytosiderophore biosynthesis";"Cysteine and methionine metabolism";"S-adenosyl-L-methionine cycle II"
Medex_00066823-RA	1	Reactome: R-HSA-9033241	"Peroxisomal protein import"
Medex_00069939-RA	6	Reactome: R-HSA-1483166;MetaCyc: PWY-6118;Reactome: R-HSA-163560;KEGG: 00564+1.1.5.3;MetaCyc: PWY-6952;MetaCyc: PWY-4261	"Synthesis of PA";"Glycerol-3-phosphate shuttle";"Triglyceride catabolism";"Glycerophospholipid metabolism";"Glycerophosphodiester degradation";"Glycerol degradation I"
Medex_00071804-RA	2	Reactome: R-HSA-6798695;Reactome: R-HSA-6811434	"Neutrophil degranulation";"COPI-dependent Golgi-to-ER retrograde traffic"
Medex_00036199-RA	1	Reactome: R-HSA-83936	"Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"
Medex_00014477-RA	3	Reactome: R-HSA-3214841;Reactome: R-HSA-8936459;Reactome: R-HSA-5617472	"PKMTs methylate histone lysines";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Activation of anterior HOX genes in hindbrain development during early embryogenesis"
Medex_00035548-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00005861-RA	2	KEGG: 00500+3.2.1.4;MetaCyc: PWY-6788	"Starch and sucrose metabolism";"Cellulose degradation II (fungi)"
Medex_00072629-RA	3	KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16	"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation"
Medex_00008255-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Medex_00080274-RA	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
Medex_00023111-RA	5	Reactome: R-HSA-72163;Reactome: R-HSA-77595;Reactome: R-HSA-73856;Reactome: R-HSA-72187;Reactome: R-HSA-159231	"mRNA Splicing - Major Pathway";"Processing of Intronless Pre-mRNAs";"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing";"Transport of Mature mRNA Derived from an Intronless Transcript"
Medex_00061214-RA	4	MetaCyc: PWY-7822;MetaCyc: PWY-6855;MetaCyc: PWY-6902;KEGG: 00520+3.2.1.14	"Chitin degradation III (Serratia)";"Chitin degradation I (archaea)";"Chitin degradation II (Vibrio)";"Amino sugar and nucleotide sugar metabolism"
Medex_00020317-RA	6	KEGG: 00073+1.2.1.84;MetaCyc: PWY-7656;MetaCyc: PWY-7782;MetaCyc: PWY-6733;Reactome: R-HSA-9640463;MetaCyc: PWY-5884	"Cutin, suberine and wax biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Plasmalogen biosynthesis";"Sporopollenin precursors biosynthesis";"Wax biosynthesis";"Wax esters biosynthesis I"
Medex_00037138-RA	1	Reactome: R-HSA-2132295	"MHC class II antigen presentation"
Medex_00086309-RA	5	Reactome: R-HSA-73772;Reactome: R-HSA-73762;Reactome: R-HSA-427413;Reactome: R-HSA-5250924;Reactome: R-HSA-73863	"RNA Polymerase I Promoter Escape";"RNA Polymerase I Transcription Initiation";"NoRC negatively regulates rRNA expression";"B-WICH complex positively regulates rRNA expression";"RNA Polymerase I Transcription Termination"
Medex_00061035-RA	3	Reactome: R-HSA-4086400;Reactome: R-HSA-373080;Reactome: R-HSA-3238698	"PCP/CE pathway";"Class B/2 (Secretin family receptors)";"WNT ligand biogenesis and trafficking"
Medex_00056703-RA	3	Reactome: R-HSA-5663213;Reactome: R-HSA-4420097;Reactome: R-HSA-2029482	"RHO GTPases Activate WASPs and WAVEs";"VEGFA-VEGFR2 Pathway";"Regulation of actin dynamics for phagocytic cup formation"
Medex_00073242-RA	10	KEGG: 00604+3.2.1.23;MetaCyc: PWY-6807;KEGG: 00511+3.2.1.23;Reactome: R-HSA-2024096;Reactome: R-HSA-2206292;Reactome: R-HSA-2160916;KEGG: 00600+3.2.1.23;Reactome: R-HSA-6798695;KEGG: 00531+3.2.1.23;KEGG: 00052+3.2.1.23	"Glycosphingolipid biosynthesis - ganglio series";"Xyloglucan degradation II (exoglucanase)";"Other glycan degradation";"HS-GAG degradation";"MPS VII - Sly syndrome";"Hyaluronan uptake and degradation";"Sphingolipid metabolism";"Neutrophil degranulation";"Glycosaminoglycan degradation";"Galactose metabolism"
Medex_00089597-RA	16	Reactome: R-HSA-6791226;Reactome: R-HSA-72702;Reactome: R-HSA-72764;Reactome: R-HSA-72706;Reactome: R-HSA-975956;Reactome: R-HSA-9633012;Reactome: R-HSA-1799339;Reactome: R-HSA-975957;Reactome: R-HSA-2408557;Reactome: R-HSA-72689;Reactome: R-HSA-156902;Reactome: R-HSA-72695;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-72649;Reactome: R-HSA-192823	"Major pathway of rRNA processing in the nucleolus and cytosol";"Ribosomal scanning and start codon recognition";"Eukaryotic Translation Termination";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Selenocysteine synthesis";"Formation of a pool of free 40S subunits";"Peptide chain elongation";"Formation of the ternary complex, and subsequently, the 43S complex";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Translation initiation complex formation";"Viral mRNA Translation"
Medex_00015370-RA	1	Reactome: R-HSA-110357	"Displacement of DNA glycosylase by APEX1"
Medex_00033883-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Medex_00065338-RA	12	Reactome: R-HSA-73772;Reactome: R-HSA-1834949;Reactome: R-HSA-73762;Reactome: R-HSA-5250924;Reactome: R-HSA-73863;Reactome: R-HSA-76066;Reactome: R-HSA-749476;Reactome: R-HSA-76071;Reactome: R-HSA-73980;Reactome: R-HSA-76061;Reactome: R-HSA-73780;Reactome: R-HSA-427413	"RNA Polymerase I Promoter Escape";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase I Transcription Initiation";"B-WICH complex positively regulates rRNA expression";"RNA Polymerase I Transcription Termination";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Transcription Termination";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Chain Elongation";"NoRC negatively regulates rRNA expression"
Medex_00006701-RA	1	Reactome: R-HSA-912446	"Meiotic recombination"
Medex_00018161-RA	9	Reactome: R-HSA-76042;Reactome: R-HSA-167162;Reactome: R-HSA-73779;Reactome: R-HSA-6804756;Reactome: R-HSA-167172;Reactome: R-HSA-167161;Reactome: R-HSA-75953;Reactome: R-HSA-73776;Reactome: R-HSA-674695	"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Regulation of TP53 Activity through Phosphorylation";"Transcription of the HIV genome";"HIV Transcription Initiation";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Pre-transcription Events"
Medex_00012001-RA	2	KEGG: 00520+2.4.1.16;MetaCyc: PWY-6981	"Amino sugar and nucleotide sugar metabolism";"Chitin biosynthesis"
Medex_00009599-RA	5	Reactome: R-HSA-5625740;Reactome: R-HSA-75035;Reactome: R-HSA-5628897;Reactome: R-HSA-1445148;Reactome: R-HSA-111447	"RHO GTPases activate PKNs";"Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex";"TP53 Regulates Metabolic Genes";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Activation of BAD and translocation to mitochondria"
Medex_00031550-RA	1	Reactome: R-HSA-77108	"Utilization of Ketone Bodies"
Medex_00066704-RA	13	MetaCyc: PWY-7721;MetaCyc: PWY-7182;MetaCyc: PWY-6859;MetaCyc: PWY-7141;MetaCyc: PWY-6383;KEGG: 00900+2.5.1.10+2.5.1.1;MetaCyc: PWY-7659;MetaCyc: PWY-7410;MetaCyc: PWY-7102;MetaCyc: PWY-5122;MetaCyc: PWY-7709;MetaCyc: PWY-5123;MetaCyc: PWY-7736	"Methyl phomopsenoate biosynthesis";"Linalool biosynthesis I";"All-trans-farnesol biosynthesis";"(3S)-linalool biosynthesis";"Mono-trans, poly-cis decaprenyl phosphate biosynthesis";"Terpenoid backbone biosynthesis";"Viridicatumtoxin biosynthesis";"Ipsdienol biosynthesis";"Bisabolene biosynthesis (engineered)";"Geranyl diphosphate biosynthesis";"(3R)-linalool biosynthesis";"Trans, trans-farnesyl diphosphate biosynthesis";"Stellatic acid biosynthesis"
Medex_00022458-RA	2	Reactome: R-HSA-8986944;Reactome: R-HSA-203927	"Transcriptional Regulation by MECP2";"MicroRNA (miRNA) biogenesis"
Medex_00005599-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00056830-RA	3	Reactome: R-HSA-212436;Reactome: R-HSA-381340;Reactome: R-HSA-1989781	"Generic Transcription Pathway";"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression"
Medex_00012617-RA	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
Medex_00048050-RA	2	KEGG: 00030+2.7.6.1;KEGG: 00230+2.7.6.1	"Pentose phosphate pathway";"Purine metabolism"
Medex_00059461-RA	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
Medex_00072482-RA	13	Reactome: R-HSA-1799339;Reactome: R-HSA-9633012;Reactome: R-HSA-156902;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-975957;Reactome: R-HSA-192823;Reactome: R-HSA-2408557;Reactome: R-HSA-6791226;Reactome: R-HSA-72706;Reactome: R-HSA-975956;Reactome: R-HSA-72764;Reactome: R-HSA-72689	"SRP-dependent cotranslational protein targeting to membrane";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Viral mRNA Translation";"Selenocysteine synthesis";"Major pathway of rRNA processing in the nucleolus and cytosol";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Formation of a pool of free 40S subunits"
Medex_00044726-RA	3	Reactome: R-HSA-4420097;Reactome: R-HSA-2029482;Reactome: R-HSA-5663213	"VEGFA-VEGFR2 Pathway";"Regulation of actin dynamics for phagocytic cup formation";"RHO GTPases Activate WASPs and WAVEs"
Medex_00051510-RA	6	Reactome: R-HSA-69052;Reactome: R-HSA-68867;Reactome: R-HSA-68949;Reactome: R-HSA-176974;Reactome: R-HSA-68962;Reactome: R-HSA-176187	"Switching of origins to a post-replicative state";"Assembly of the pre-replicative complex";"Orc1 removal from chromatin";"Unwinding of DNA";"Activation of the pre-replicative complex";"Activation of ATR in response to replication stress"
Medex_00038809-RA	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00092260-RA	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
Medex_00031733-RA	19	Reactome: R-HSA-8856828;Reactome: R-HSA-8963901;Reactome: R-HSA-3000480;Reactome: R-HSA-8963888;Reactome: R-HSA-8964041;Reactome: R-HSA-975634;Reactome: R-HSA-3000497;Reactome: R-HSA-202733;Reactome: R-HSA-8957275;Reactome: R-HSA-3000471;Reactome: R-HSA-381426;Reactome: R-HSA-8964046;Reactome: R-HSA-8964038;Reactome: R-HSA-432142;Reactome: R-HSA-8866423;Reactome: R-HSA-8964026;Reactome: R-HSA-8856825;Reactome: R-HSA-3000484;Reactome: R-HSA-5686938	"Clathrin-mediated endocytosis";"Chylomicron remodeling";"Scavenging by Class A Receptors";"Chylomicron assembly";"LDL remodeling";"Retinoid metabolism and transport";"Scavenging by Class H Receptors";"Cell surface interactions at the vascular wall";"Post-translational protein phosphorylation";"Scavenging by Class B Receptors";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"VLDL clearance";"LDL clearance";"Platelet sensitization by LDL";"VLDL assembly";"Chylomicron clearance";"Cargo recognition for clathrin-mediated endocytosis";"Scavenging by Class F Receptors";"Regulation of TLR by endogenous ligand"
Medex_00051149-RA	5	Reactome: R-HSA-2132295;Reactome: R-HSA-6798695;Reactome: R-HSA-1660662;Reactome: R-HSA-4085001;Reactome: R-HSA-4341670	"MHC class II antigen presentation";"Neutrophil degranulation";"Glycosphingolipid metabolism";"Sialic acid metabolism";"Defective NEU1 causes sialidosis"
Medex_00006690-RA	1	Reactome: R-HSA-1660661	"Sphingolipid de novo biosynthesis"
Medex_00041480-RA	2	Reactome: R-HSA-5576893;Reactome: R-HSA-5576892	"Phase 2 - plateau phase";"Phase 0 - rapid depolarisation"
Medex_00065526-RA	2	Reactome: R-HSA-9610379;Reactome: R-HSA-917729	"HCMV Late Events";"Endosomal Sorting Complex Required For Transport (ESCRT)"
Medex_00011953-RA	1	Reactome: R-HSA-1660499	"Synthesis of PIPs at the plasma membrane"
Medex_00000554-RA	1	KEGG: 00480+3.4.11.2	"Glutathione metabolism"
Medex_00048838-RA	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
Medex_00070508-RA	2	Reactome: R-HSA-446193;KEGG: 00510+2.4.1.256	"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"N-Glycan biosynthesis"
Medex_00060494-RA	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
Medex_00042713-RA	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840	"Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation"
Medex_00033935-RA	5	Reactome: R-HSA-917977;Reactome: R-HSA-9639288;Reactome: R-HSA-1222556;Reactome: R-HSA-983712;Reactome: R-HSA-77387	"Transferrin endocytosis and recycling";"Amino acids regulate mTORC1";"ROS and RNS production in phagocytes";"Ion channel transport";"Insulin receptor recycling"
Medex_00048903-RA	2	Reactome: R-HSA-5620924;Reactome: R-HSA-5610787	"Intraflagellar transport";"Hedgehog 'off' state"
Medex_00023357-RA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Medex_00036536-RA	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
Medex_00050045-RA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00048810-RA	2	Reactome: R-HSA-1660662;Reactome: R-HSA-390471	"Glycosphingolipid metabolism";"Association of TriC/CCT with target proteins during biosynthesis"
Medex_00004922-RA	18	Reactome: R-HSA-6796648;Reactome: R-HSA-167238;Reactome: R-HSA-72086;Reactome: R-HSA-112382;Reactome: R-HSA-77075;Reactome: R-HSA-167158;Reactome: R-HSA-6807505;Reactome: R-HSA-113418;Reactome: R-HSA-75955;Reactome: R-HSA-167160;Reactome: R-HSA-167246;Reactome: R-HSA-167200;Reactome: R-HSA-167290;Reactome: R-HSA-167242;Reactome: R-HSA-674695;Reactome: R-HSA-167152;Reactome: R-HSA-167243;Reactome: R-HSA-167287	"TP53 Regulates Transcription of DNA Repair Genes";"Pausing and recovery of Tat-mediated HIV elongation";"mRNA Capping";"Formation of RNA Pol II elongation complex";"RNA Pol II CTD phosphorylation and interaction with CE";"Formation of the HIV-1 Early Elongation Complex";"RNA polymerase II transcribes snRNA genes";"Formation of the Early Elongation Complex";"RNA Polymerase II Transcription Elongation";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Tat-mediated elongation of the HIV-1 transcript";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Pausing and recovery of HIV elongation";"Abortive elongation of HIV-1 transcript in the absence of Tat";"RNA Polymerase II Pre-transcription Events";"Formation of HIV elongation complex in the absence of HIV Tat";"Tat-mediated HIV elongation arrest and recovery";"HIV elongation arrest and recovery"
Medex_00092997-RA	5	Reactome: R-HSA-5625740;Reactome: R-HSA-75035;Reactome: R-HSA-5628897;Reactome: R-HSA-1445148;Reactome: R-HSA-111447	"RHO GTPases activate PKNs";"Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex";"TP53 Regulates Metabolic Genes";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Activation of BAD and translocation to mitochondria"
Medex_00023522-RA	3	Reactome: R-HSA-6811434;Reactome: R-HSA-6798695;Reactome: R-HSA-6807878	"COPI-dependent Golgi-to-ER retrograde traffic";"Neutrophil degranulation";"COPI-mediated anterograde transport"
Medex_00070217-RA	3	Reactome: R-HSA-73621;Reactome: R-HSA-74259;Reactome: R-HSA-196807	"Pyrimidine catabolism";"Purine catabolism";"Nicotinate metabolism"
Medex_00002610-RA	1	Reactome: R-HSA-163560	"Triglyceride catabolism"
Medex_00039619-RA	4	Reactome: R-HSA-4655427;Reactome: R-HSA-5334118;KEGG: 00270+2.1.1.37;Reactome: R-HSA-212300	"SUMOylation of DNA methylation proteins";"DNA methylation";"Cysteine and methionine metabolism";"PRC2 methylates histones and DNA"
Medex_00074236-RA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
Medex_00030131-RA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
Medex_00042986-RA	6	Reactome: R-HSA-4793952;KEGG: 00513+2.4.1.143;KEGG: 00510+2.4.1.143;MetaCyc: PWY-7426;MetaCyc: PWY-7920;Reactome: R-HSA-975578	"Defective MGAT2 causes MGAT2-CDG (CDG-2a)";"Various types of N-glycan biosynthesis";"N-Glycan biosynthesis";"Complex N-linked glycan biosynthesis (vertebrates)";"Complex N-linked glycan biosynthesis (plants)";"Reactions specific to the complex N-glycan synthesis pathway"
Medex_00016577-RA	56	Reactome: R-HSA-187577;Reactome: R-HSA-174084;Reactome: R-HSA-5610783;Reactome: R-HSA-1236974;Reactome: R-HSA-8854050;Reactome: R-HSA-69481;Reactome: R-HSA-5678895;Reactome: R-HSA-350562;Reactome: R-HSA-174113;Reactome: R-HSA-4641257;Reactome: R-HSA-5362768;Reactome: R-HSA-69017;Reactome: R-HSA-69601;Reactome: R-HSA-1234176;Reactome: R-HSA-5676590;Reactome: R-HSA-68827;Reactome: R-HSA-8948751;Reactome: R-HSA-9604323;Reactome: R-HSA-1169091;Reactome: R-HSA-174154;Reactome: R-HSA-5607764;Reactome: R-HSA-174184;Reactome: R-HSA-8951664;Reactome: R-HSA-2871837;Reactome: R-HSA-5658442;Reactome: R-HSA-8941858;Reactome: R-HSA-5358346;Reactome: R-HSA-983168;Reactome: R-HSA-202424;Reactome: R-HSA-9020702;Reactome: R-HSA-4641258;Reactome: R-HSA-2467813;Reactome: R-HSA-180585;Reactome: R-HSA-450408;Reactome: R-HSA-9010553;Reactome: R-HSA-68949;Reactome: R-HSA-382556;Reactome: R-HSA-8939236;Reactome: R-HSA-211733;Reactome: R-HSA-8939902;Reactome: R-HSA-75815;Reactome: R-HSA-195253;Reactome: R-HSA-5610785;Reactome: R-HSA-5689880;Reactome: R-HSA-5668541;Reactome: R-HSA-5689603;Reactome: R-HSA-5687128;Reactome: R-HSA-4608870;Reactome: R-HSA-5632684;Reactome: R-HSA-1236978;Reactome: R-HSA-349425;Reactome: R-HSA-180534;Reactome: R-HSA-5607761;Reactome: R-HSA-8852276;Reactome: R-HSA-5610780;Reactome: R-HSA-174178	"SCF(Skp2)-mediated degradation of p27/p21";"Autodegradation of Cdh1 by Cdh1:APC/C";"Degradation of GLI2 by the proteasome";"ER-Phagosome pathway";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"G2/M Checkpoints";"Defective CFTR causes cystic fibrosis";"Regulation of ornithine decarboxylase (ODC)";"SCF-beta-TrCP mediated degradation of Emi1";"Degradation of AXIN";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"CDK-mediated phosphorylation and removal of Cdc6";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"NIK-->noncanonical NF-kB signaling";"CDT1 association with the CDC6:ORC:origin complex";"Regulation of PTEN stability and activity";"Negative regulation of NOTCH4 signaling";"Activation of NF-kappaB in B cells";"APC/C:Cdc20 mediated degradation of Securin";"CLEC7A (Dectin-1) signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Neddylation";"FCERI mediated NF-kB activation";"Regulation of RAS by GAPs";"Regulation of RUNX3 expression and activity";"Hedgehog ligand biogenesis";"Antigen processing: Ubiquitination & Proteasome degradation";"Downstream TCR signaling";"Interleukin-1 signaling";"Degradation of DVL";"Separation of Sister Chromatids";"Vif-mediated degradation of APOBEC3G";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Regulation of expression of SLITs and ROBOs";"Orc1 removal from chromatin";"ABC-family proteins mediated transport";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Regulation of RUNX2 expression and activity";"Ubiquitin-dependent degradation of Cyclin D";"Degradation of beta-catenin by the destruction complex";"GLI3 is processed to GLI3R by the proteasome";"Ub-specific processing proteases";"TNFR2 non-canonical NF-kB pathway";"UCH proteinases";"MAPK6/MAPK4 signaling";"Asymmetric localization of PCP proteins";"Hedgehog 'on' state";"Cross-presentation of soluble exogenous antigens (endosomes)";"Autodegradation of the E3 ubiquitin ligase COP1";"Vpu mediated degradation of CD4";"Dectin-1 mediated noncanonical NF-kB signaling";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Degradation of GLI1 by the proteasome";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1"
Medex_00072296-RA	4	Reactome: R-HSA-8856825;Reactome: R-HSA-6781823;Reactome: R-HSA-5696394;Reactome: R-HSA-8951664	"Cargo recognition for clathrin-mediated endocytosis";"Formation of TC-NER Pre-Incision Complex";"DNA Damage Recognition in GG-NER";"Neddylation"
Medex_00068691-RA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
Medex_00090298-RA	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
Medex_00092045-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Medex_00022205-RA	3	Reactome: R-HSA-193648;Reactome: R-HSA-194840;Reactome: R-HSA-416482	"NRAGE signals death through JNK";"Rho GTPase cycle";"G alpha (12/13) signalling events"
Medex_00100776-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Medex_00049168-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Medex_00065120-RA	7	KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1	"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Thermogenesis";"Relaxin signaling pathway";"Human cytomegalovirus infection"
Medex_00087228-RA	2	Reactome: R-HSA-1660662;Reactome: R-HSA-390471	"Glycosphingolipid metabolism";"Association of TriC/CCT with target proteins during biosynthesis"
Medex_00019026-RA	16	Reactome: R-HSA-176407;Reactome: R-HSA-69017;Reactome: R-HSA-174184;Reactome: R-HSA-8853884;Reactome: R-HSA-174154;Reactome: R-HSA-174178;Reactome: R-HSA-176412;Reactome: R-HSA-983168;Reactome: R-HSA-174048;Reactome: R-HSA-176408;Reactome: R-HSA-141430;Reactome: R-HSA-174084;Reactome: R-HSA-2559582;Reactome: R-HSA-179409;Reactome: R-HSA-176409;Reactome: R-HSA-2467813	"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"CDK-mediated phosphorylation and removal of Cdc6";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Transcriptional Regulation by VENTX";"APC/C:Cdc20 mediated degradation of Securin";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Phosphorylation of the APC/C";"Antigen processing: Ubiquitination & Proteasome degradation";"APC/C:Cdc20 mediated degradation of Cyclin B";"Regulation of APC/C activators between G1/S and early anaphase";"Inactivation of APC/C via direct inhibition of the APC/C complex";"Autodegradation of Cdh1 by Cdh1:APC/C";"Senescence-Associated Secretory Phenotype (SASP)";"APC-Cdc20 mediated degradation of Nek2A";"APC/C:Cdc20 mediated degradation of mitotic proteins";"Separation of Sister Chromatids"
Medex_00048840-RA	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
Medex_00038295-RA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
Medex_00040513-RA	26	Reactome: R-HSA-210744;Reactome: R-HSA-9614657;Reactome: R-HSA-1234158;Reactome: R-HSA-8866907;Reactome: R-HSA-381340;Reactome: R-HSA-2122947;Reactome: R-HSA-9013695;Reactome: R-HSA-3899300;Reactome: R-HSA-2894862;Reactome: R-HSA-933541;Reactome: R-HSA-5621575;Reactome: R-HSA-5617472;Reactome: R-HSA-918233;Reactome: R-HSA-3371568;Reactome: R-HSA-9018519;Reactome: R-HSA-1368082;Reactome: R-HSA-8941856;Reactome: R-HSA-3134973;Reactome: R-HSA-9617629;Reactome: R-HSA-2644606;Reactome: R-HSA-3214847;Reactome: R-HSA-201722;Reactome: R-HSA-9013508;Reactome: R-HSA-1989781;Reactome: R-HSA-400253;Reactome: R-HSA-1912408	"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"FOXO-mediated transcription of cell death genes";"Regulation of gene expression by Hypoxia-inducible Factor";"Activation of the TFAP2 (AP-2) family of transcription factors";"Transcriptional regulation of white adipocyte differentiation";"NOTCH1 Intracellular Domain Regulates Transcription";"NOTCH4 Intracellular Domain Regulates Transcription";"SUMOylation of transcription cofactors";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"TRAF6 mediated IRF7 activation";"CD209 (DC-SIGN) signaling";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"TRAF3-dependent IRF activation pathway";"Attenuation phase";"Estrogen-dependent gene expression";"RORA activates gene expression";"RUNX3 regulates NOTCH signaling";"LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production";"Regulation of FOXO transcriptional activity by acetylation";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"HATs acetylate histones";"Formation of the beta-catenin:TCF transactivating complex";"NOTCH3 Intracellular Domain Regulates Transcription";"PPARA activates gene expression";"Circadian Clock";"Pre-NOTCH Transcription and Translation"
Medex_00077916-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00048141-RA	1	Reactome: R-HSA-1474228	"Degradation of the extracellular matrix"
Medex_00047437-RA	14	KEGG: 00564+3.1.1.4+3.1.1.5;KEGG: 00592+3.1.1.4;MetaCyc: PWY-7783;Reactome: R-HSA-1482788;MetaCyc: PWY-7416;KEGG: 00590+3.1.1.4;KEGG: 00565+3.1.1.4;Reactome: R-HSA-975634;MetaCyc: PWY-6803;MetaCyc: PWY-8051;MetaCyc: PWY-7409;MetaCyc: PWY-7417;KEGG: 00591+3.1.1.4;MetaCyc: PWY-8053	"Glycerophospholipid metabolism";"alpha-Linolenic acid metabolism";"Plasmalogen degradation";"Acyl chain remodelling of PC";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Arachidonic acid metabolism";"Ether lipid metabolism";"Retinoid metabolism and transport";"Phosphatidylcholine acyl editing";"Anandamide biosynthesis I";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Phospholipid remodeling (phosphatidate, yeast)";"Linoleic acid metabolism";"Anandamide biosynthesis II"
Medex_00012885-RA	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
Medex_00017356-RA	1	Reactome: R-HSA-70171	"Glycolysis"
Medex_00008717-RA	1	KEGG: 00480+3.4.11.2	"Glutathione metabolism"
Medex_00051539-RA	2	MetaCyc: PWY-7286;MetaCyc: PWY-7285	"7-(3-amino-3-carboxypropyl)-wyosine biosynthesis";"Methylwyosine biosynthesis"
Medex_00028185-RA	1	Reactome: R-HSA-5649702	"APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway"
Medex_00063368-RA	1	Reactome: R-HSA-2299718	"Condensation of Prophase Chromosomes"
Medex_00026030-RA	1	KEGG: 00860+4.4.1.17	"Porphyrin and chlorophyll metabolism"
Medex_00009723-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Medex_00052508-RA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
Medex_00083107-RA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Medex_00064812-RA	2	Reactome: R-HSA-390471;Reactome: R-HSA-1660662	"Association of TriC/CCT with target proteins during biosynthesis";"Glycosphingolipid metabolism"
Medex_00076688-RA	4	KEGG: 00380+1.2.4.2;KEGG: 00020+1.2.4.2;MetaCyc: PWY-5084;KEGG: 00310+1.2.4.2	"Tryptophan metabolism";"Citrate cycle (TCA cycle)";"2-oxoglutarate decarboxylation to succinyl-CoA";"Lysine degradation"
Medex_00048611-RA	1	Reactome: R-HSA-211981	"Xenobiotics"
Medex_00095821-RA	1	Reactome: R-HSA-200425	"Carnitine metabolism"
Medex_00058893-RA	1	Reactome: R-HSA-211981	"Xenobiotics"
Medex_00049935-RA	3	Reactome: R-HSA-674695;Reactome: R-HSA-75955;Reactome: R-HSA-112382	"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Elongation";"Formation of RNA Pol II elongation complex"
Medex_00050090-RA	26	Reactome: R-HSA-380320;Reactome: R-HSA-2500257;Reactome: R-HSA-3371497;Reactome: R-HSA-5663220;Reactome: R-HSA-389960;Reactome: R-HSA-1445148;Reactome: R-HSA-6811434;Reactome: R-HSA-9648025;Reactome: R-HSA-68877;Reactome: R-HSA-389977;Reactome: R-HSA-2467813;Reactome: R-HSA-9646399;Reactome: R-HSA-5617833;Reactome: R-HSA-5626467;Reactome: R-HSA-2132295;Reactome: R-HSA-190840;Reactome: R-HSA-6807878;Reactome: R-HSA-190861;Reactome: R-HSA-437239;Reactome: R-HSA-9619483;Reactome: R-HSA-8955332;Reactome: R-HSA-6811436;Reactome: R-HSA-9609690;Reactome: R-HSA-8852276;Reactome: R-HSA-983189;Reactome: R-HSA-9609736	"Recruitment of NuMA to mitotic centrosomes";"Resolution of Sister Chromatid Cohesion";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"RHO GTPases Activate Formins";"Formation of tubulin folding intermediates by CCT/TriC";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"COPI-dependent Golgi-to-ER retrograde traffic";"EML4 and NUDC in mitotic spindle formation";"Mitotic Prometaphase";"Post-chaperonin tubulin folding pathway";"Separation of Sister Chromatids";"Aggrephagy";"Cilium Assembly";"RHO GTPases activate IQGAPs";"MHC class II antigen presentation";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"COPI-mediated anterograde transport";"Gap junction assembly";"Recycling pathway of L1";"Activation of AMPK downstream of NMDARs";"Carboxyterminal post-translational modifications of tubulin";"COPI-independent Golgi-to-ER retrograde traffic";"HCMV Early Events";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Kinesins";"Assembly and cell surface presentation of NMDA receptors"
Medex_00080139-RA	3	Reactome: R-HSA-3214847;Reactome: R-HSA-5689603;Reactome: R-HSA-2151201	"HATs acetylate histones";"UCH proteinases";"Transcriptional activation of mitochondrial biogenesis"
Medex_00036154-RA	13	Reactome: R-HSA-72764;Reactome: R-HSA-72689;Reactome: R-HSA-975956;Reactome: R-HSA-72706;Reactome: R-HSA-6791226;Reactome: R-HSA-2408557;Reactome: R-HSA-192823;Reactome: R-HSA-975957;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-9633012;Reactome: R-HSA-156902;Reactome: R-HSA-1799339	"Eukaryotic Translation Termination";"Formation of a pool of free 40S subunits";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Major pathway of rRNA processing in the nucleolus and cytosol";"Selenocysteine synthesis";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Peptide chain elongation";"SRP-dependent cotranslational protein targeting to membrane"
Medex_00051757-RA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
Medex_00058738-RA	56	Reactome: R-HSA-174084;Reactome: R-HSA-187577;Reactome: R-HSA-8854050;Reactome: R-HSA-1236974;Reactome: R-HSA-5610783;Reactome: R-HSA-9604323;Reactome: R-HSA-8948751;Reactome: R-HSA-68827;Reactome: R-HSA-5676590;Reactome: R-HSA-1234176;Reactome: R-HSA-5362768;Reactome: R-HSA-69017;Reactome: R-HSA-69601;Reactome: R-HSA-4641257;Reactome: R-HSA-174113;Reactome: R-HSA-5678895;Reactome: R-HSA-350562;Reactome: R-HSA-69481;Reactome: R-HSA-2871837;Reactome: R-HSA-8951664;Reactome: R-HSA-174184;Reactome: R-HSA-5607764;Reactome: R-HSA-174154;Reactome: R-HSA-1169091;Reactome: R-HSA-9020702;Reactome: R-HSA-202424;Reactome: R-HSA-983168;Reactome: R-HSA-8941858;Reactome: R-HSA-5358346;Reactome: R-HSA-5658442;Reactome: R-HSA-68949;Reactome: R-HSA-382556;Reactome: R-HSA-8939236;Reactome: R-HSA-211733;Reactome: R-HSA-9010553;Reactome: R-HSA-450408;Reactome: R-HSA-180585;Reactome: R-HSA-2467813;Reactome: R-HSA-4641258;Reactome: R-HSA-4608870;Reactome: R-HSA-5689603;Reactome: R-HSA-5668541;Reactome: R-HSA-5687128;Reactome: R-HSA-5689880;Reactome: R-HSA-5610785;Reactome: R-HSA-195253;Reactome: R-HSA-75815;Reactome: R-HSA-8939902;Reactome: R-HSA-174178;Reactome: R-HSA-8852276;Reactome: R-HSA-5610780;Reactome: R-HSA-5607761;Reactome: R-HSA-180534;Reactome: R-HSA-1236978;Reactome: R-HSA-349425;Reactome: R-HSA-5632684	"Autodegradation of Cdh1 by Cdh1:APC/C";"SCF(Skp2)-mediated degradation of p27/p21";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"ER-Phagosome pathway";"Degradation of GLI2 by the proteasome";"Negative regulation of NOTCH4 signaling";"Regulation of PTEN stability and activity";"CDT1 association with the CDC6:ORC:origin complex";"NIK-->noncanonical NF-kB signaling";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"CDK-mediated phosphorylation and removal of Cdc6";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Degradation of AXIN";"SCF-beta-TrCP mediated degradation of Emi1";"Defective CFTR causes cystic fibrosis";"Regulation of ornithine decarboxylase (ODC)";"G2/M Checkpoints";"FCERI mediated NF-kB activation";"Neddylation";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"CLEC7A (Dectin-1) signaling";"APC/C:Cdc20 mediated degradation of Securin";"Activation of NF-kappaB in B cells";"Interleukin-1 signaling";"Downstream TCR signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Regulation of RUNX3 expression and activity";"Hedgehog ligand biogenesis";"Regulation of RAS by GAPs";"Orc1 removal from chromatin";"ABC-family proteins mediated transport";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Regulation of expression of SLITs and ROBOs";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Vif-mediated degradation of APOBEC3G";"Separation of Sister Chromatids";"Degradation of DVL";"Asymmetric localization of PCP proteins";"UCH proteinases";"TNFR2 non-canonical NF-kB pathway";"MAPK6/MAPK4 signaling";"Ub-specific processing proteases";"GLI3 is processed to GLI3R by the proteasome";"Degradation of beta-catenin by the destruction complex";"Ubiquitin-dependent degradation of Cyclin D";"Regulation of RUNX2 expression and activity";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Degradation of GLI1 by the proteasome";"Dectin-1 mediated noncanonical NF-kB signaling";"Vpu mediated degradation of CD4";"Cross-presentation of soluble exogenous antigens (endosomes)";"Autodegradation of the E3 ubiquitin ligase COP1";"Hedgehog 'on' state"
Medex_00096414-RA	1	Reactome: R-HSA-389957	"Prefoldin mediated transfer of substrate to CCT/TriC"
Medex_00022718-RA	2	Reactome: R-HSA-381340;Reactome: R-HSA-1989781	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression"
Medex_00001024-RA	3	Reactome: R-HSA-2022928;MetaCyc: PWY-6558;KEGG: 00534+5.1.3.17	"HS-GAG biosynthesis";"Heparan sulfate biosynthesis (late stages)";"Glycosaminoglycan biosynthesis - heparan sulfate / heparin"
Medex_00047164-RA	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840	"Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation"
Medex_00053681-RA	1	Reactome: R-HSA-6798163	"Choline catabolism"
Medex_00050525-RA	3	KEGG: 00195+7.1.2.2;KEGG: 00190+7.1.2.2;MetaCyc: PWY-7980	"Photosynthesis";"Oxidative phosphorylation";"ATP biosynthesis"
Medex_00092094-RA	1	Reactome: R-HSA-6798163	"Choline catabolism"
Medex_00059181-RA	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
Medex_00009504-RA	2	MetaCyc: PWY-6829;Reactome: R-HSA-6782315	"Trna methylation (yeast)";"tRNA modification in the nucleus and cytosol"
Medex_00063250-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00090464-RA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
Medex_00044331-RA	2	Reactome: R-HSA-5576886;Reactome: R-HSA-1299308	"Phase 4 - resting membrane potential";"Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK)"
Medex_00038401-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00017317-RA	2	MetaCyc: PWY-7511;Reactome: R-HSA-8866654	"Protein ubiquitination";"E3 ubiquitin ligases ubiquitinate target proteins"
Medex_00070413-RA	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
Medex_00023800-RA	1	Reactome: R-HSA-5658442	"Regulation of RAS by GAPs"
Medex_00083921-RA	2	Reactome: R-HSA-1660662;Reactome: R-HSA-390471	"Glycosphingolipid metabolism";"Association of TriC/CCT with target proteins during biosynthesis"
Medex_00039925-RA	56	Reactome: R-HSA-69017;Reactome: R-HSA-5362768;Reactome: R-HSA-69601;Reactome: R-HSA-1234176;Reactome: R-HSA-5676590;Reactome: R-HSA-8948751;Reactome: R-HSA-9604323;Reactome: R-HSA-68827;Reactome: R-HSA-69481;Reactome: R-HSA-5678895;Reactome: R-HSA-350562;Reactome: R-HSA-174113;Reactome: R-HSA-4641257;Reactome: R-HSA-8951664;Reactome: R-HSA-2871837;Reactome: R-HSA-1169091;Reactome: R-HSA-174154;Reactome: R-HSA-174184;Reactome: R-HSA-5607764;Reactome: R-HSA-187577;Reactome: R-HSA-174084;Reactome: R-HSA-5610783;Reactome: R-HSA-1236974;Reactome: R-HSA-8854050;Reactome: R-HSA-5689880;Reactome: R-HSA-5610785;Reactome: R-HSA-5668541;Reactome: R-HSA-5689603;Reactome: R-HSA-5687128;Reactome: R-HSA-4608870;Reactome: R-HSA-8939902;Reactome: R-HSA-75815;Reactome: R-HSA-195253;Reactome: R-HSA-5607761;Reactome: R-HSA-5610780;Reactome: R-HSA-8852276;Reactome: R-HSA-174178;Reactome: R-HSA-5632684;Reactome: R-HSA-1236978;Reactome: R-HSA-349425;Reactome: R-HSA-180534;Reactome: R-HSA-9020702;Reactome: R-HSA-5658442;Reactome: R-HSA-8941858;Reactome: R-HSA-5358346;Reactome: R-HSA-983168;Reactome: R-HSA-202424;Reactome: R-HSA-9010553;Reactome: R-HSA-68949;Reactome: R-HSA-382556;Reactome: R-HSA-8939236;Reactome: R-HSA-211733;Reactome: R-HSA-4641258;Reactome: R-HSA-2467813;Reactome: R-HSA-180585;Reactome: R-HSA-450408	"CDK-mediated phosphorylation and removal of Cdc6";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"NIK-->noncanonical NF-kB signaling";"Regulation of PTEN stability and activity";"Negative regulation of NOTCH4 signaling";"CDT1 association with the CDC6:ORC:origin complex";"G2/M Checkpoints";"Defective CFTR causes cystic fibrosis";"Regulation of ornithine decarboxylase (ODC)";"SCF-beta-TrCP mediated degradation of Emi1";"Degradation of AXIN";"Neddylation";"FCERI mediated NF-kB activation";"Activation of NF-kappaB in B cells";"APC/C:Cdc20 mediated degradation of Securin";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"CLEC7A (Dectin-1) signaling";"SCF(Skp2)-mediated degradation of p27/p21";"Autodegradation of Cdh1 by Cdh1:APC/C";"Degradation of GLI2 by the proteasome";"ER-Phagosome pathway";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Ub-specific processing proteases";"GLI3 is processed to GLI3R by the proteasome";"TNFR2 non-canonical NF-kB pathway";"UCH proteinases";"MAPK6/MAPK4 signaling";"Asymmetric localization of PCP proteins";"Regulation of RUNX2 expression and activity";"Ubiquitin-dependent degradation of Cyclin D";"Degradation of beta-catenin by the destruction complex";"Dectin-1 mediated noncanonical NF-kB signaling";"Degradation of GLI1 by the proteasome";"The role of GTSE1 in G2/M progression after G2 checkpoint";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Hedgehog 'on' state";"Cross-presentation of soluble exogenous antigens (endosomes)";"Autodegradation of the E3 ubiquitin ligase COP1";"Vpu mediated degradation of CD4";"Interleukin-1 signaling";"Regulation of RAS by GAPs";"Regulation of RUNX3 expression and activity";"Hedgehog ligand biogenesis";"Antigen processing: Ubiquitination & Proteasome degradation";"Downstream TCR signaling";"Regulation of expression of SLITs and ROBOs";"Orc1 removal from chromatin";"ABC-family proteins mediated transport";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Degradation of DVL";"Separation of Sister Chromatids";"Vif-mediated degradation of APOBEC3G";"AUF1 (hnRNP D0) binds and destabilizes mRNA"
Medex_00072677-RA	1	Reactome: R-HSA-2470946	"Cohesin Loading onto Chromatin"
Medex_00014830-RA	2	KEGG: 00511+3.2.1.24;Reactome: R-HSA-8853383	"Other glycan degradation";"Lysosomal oligosaccharide catabolism"
Medex_00046441-RA	7	KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1	"Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Human papillomavirus infection";"Relaxin signaling pathway";"Thermogenesis";"Human cytomegalovirus infection"
Medex_00103419-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Medex_00060138-RA	2	Reactome: R-HSA-917729;Reactome: R-HSA-9610379	"Endosomal Sorting Complex Required For Transport (ESCRT)";"HCMV Late Events"
Medex_00030139-RA	22	Reactome: R-HSA-5339716;Reactome: R-HSA-5675221;Reactome: R-HSA-5358747;Reactome: R-HSA-2500257;Reactome: R-HSA-5358752;Reactome: R-HSA-5663220;Reactome: R-HSA-196299;Reactome: R-HSA-9648025;Reactome: R-HSA-68877;Reactome: R-HSA-5467340;Reactome: R-HSA-2467813;Reactome: R-HSA-5467337;Reactome: R-HSA-4641262;Reactome: R-HSA-141444;Reactome: R-HSA-195253;Reactome: R-HSA-389513;Reactome: R-HSA-432142;Reactome: R-HSA-5673000;Reactome: R-HSA-5358749;Reactome: R-HSA-5467348;Reactome: R-HSA-5358751;Reactome: R-HSA-6811558	"Misspliced GSK3beta mutants stabilize beta-catenin";"Negative regulation of MAPK pathway";"S33 mutants of beta-catenin aren't phosphorylated";"Resolution of Sister Chromatid Cohesion";"T41 mutants of beta-catenin aren't phosphorylated";"RHO GTPases Activate Formins";"Beta-catenin phosphorylation cascade";"EML4 and NUDC in mitotic spindle formation";"Mitotic Prometaphase";"AXIN missense mutants destabilize the destruction complex";"Separation of Sister Chromatids";"APC truncation mutants have impaired AXIN binding";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Degradation of beta-catenin by the destruction complex";"CTLA4 inhibitory signaling";"Platelet sensitization by LDL";"RAF activation";"S37 mutants of beta-catenin aren't phosphorylated";"Truncations of AMER1 destabilize the destruction complex";"S45 mutants of beta-catenin aren't phosphorylated";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"
Medex_00055261-RA	42	Reactome: R-HSA-73772;Reactome: R-HSA-73728;Reactome: R-HSA-5693607;Reactome: R-HSA-8939236;Reactome: R-HSA-110330;Reactome: R-HSA-5693565;Reactome: R-HSA-3214815;Reactome: R-HSA-69473;Reactome: R-HSA-8936459;Reactome: R-HSA-3214842;Reactome: R-HSA-5625886;Reactome: R-HSA-912446;Reactome: R-HSA-9616222;Reactome: R-HSA-4551638;Reactome: R-HSA-3214847;Reactome: R-HSA-427413;Reactome: R-HSA-201722;Reactome: R-HSA-171306;Reactome: R-HSA-110329;Reactome: R-HSA-2559580;Reactome: R-HSA-1221632;Reactome: R-HSA-606279;Reactome: R-HSA-5250924;Reactome: R-HSA-212300;Reactome: R-HSA-110331;Reactome: R-HSA-9018519;Reactome: R-HSA-5617472;Reactome: R-HSA-2559586;Reactome: R-HSA-5578749;Reactome: R-HSA-2559582;Reactome: R-HSA-3214841;Reactome: R-HSA-3214858;Reactome: R-HSA-427389;Reactome: R-HSA-2299718;Reactome: R-HSA-110328;Reactome: R-HSA-5693571;Reactome: R-HSA-1912408;Reactome: R-HSA-9610379;Reactome: R-HSA-977225;Reactome: R-HSA-9609690;Reactome: R-HSA-427359;Reactome: R-HSA-5334118	"RNA Polymerase I Promoter Escape";"RNA Polymerase I Promoter Opening";"Processing of DNA double-strand break ends";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Recognition and association of DNA glycosylase with site containing an affected purine";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"HDACs deacetylate histones";"G2/M DNA damage checkpoint";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"HDMs demethylate histones";"Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3";"Meiotic recombination";"Transcriptional regulation of granulopoiesis";"SUMOylation of chromatin organization proteins";"HATs acetylate histones";"NoRC negatively regulates rRNA expression";"Formation of the beta-catenin:TCF transactivating complex";"Packaging Of Telomere Ends";"Cleavage of the damaged pyrimidine";"Oxidative Stress Induced Senescence";"Meiotic synapsis";"Deposition of new CENPA-containing nucleosomes at the centromere";"B-WICH complex positively regulates rRNA expression";"PRC2 methylates histones and DNA";"Cleavage of the damaged purine";"Estrogen-dependent gene expression";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"DNA Damage/Telomere Stress Induced Senescence";"Transcriptional regulation by small RNAs";"Senescence-Associated Secretory Phenotype (SASP)";"PKMTs methylate histone lysines";"RMTs methylate histone arginines";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"Condensation of Prophase Chromosomes";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"Nonhomologous End-Joining (NHEJ)";"Pre-NOTCH Transcription and Translation";"HCMV Late Events";"Amyloid fiber formation";"HCMV Early Events";"SIRT1 negatively regulates rRNA expression";"DNA methylation"
Medex_00080099-RA	2	Reactome: R-HSA-1268020;Reactome: R-HSA-8869496	"Mitochondrial protein import";"TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation"
Medex_00093003-RA	1	KEGG: 00480+3.4.11.1	"Glutathione metabolism"
Medex_00064295-RA	4	KEGG: 00983+6.3.5.2;KEGG: 00230+6.3.5.2;MetaCyc: PWY-7221;Reactome: R-HSA-73817	"Drug metabolism - other enzymes";"Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis";"Purine ribonucleoside monophosphate biosynthesis"
Medex_00087726-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00044508-RA	1	Reactome: R-HSA-71262	"Carnitine synthesis"
Medex_00013804-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00075706-RA	10	MetaCyc: PWY-5278;Reactome: R-HSA-174362;MetaCyc: PWY-5340;MetaCyc: PWY-6683;KEGG: 00450+2.7.7.4;KEGG: 00230+2.7.7.4;KEGG: 00261+2.7.7.4;MetaCyc: PWY-6932;Reactome: R-HSA-2408550;KEGG: 00920+2.7.7.4	"Sulfite oxidation III";"Transport and synthesis of PAPS";"Sulfate activation for sulfonation";"Assimilatory sulfate reduction III";"Selenocompound metabolism";"Purine metabolism";"Monobactam biosynthesis";"Selenate reduction";"Metabolism of ingested H2SeO4 and H2SeO3 into H2Se";"Sulfur metabolism"
Medex_00016035-RA	2	Reactome: R-HSA-6783310;Reactome: R-HSA-6796648	"Fanconi Anemia Pathway";"TP53 Regulates Transcription of DNA Repair Genes"
Medex_00004063-RA	2	MetaCyc: PWY-6788;KEGG: 00500+3.2.1.4	"Cellulose degradation II (fungi)";"Starch and sucrose metabolism"
Medex_00046033-RA	1	Reactome: R-HSA-2024096	"HS-GAG degradation"
Medex_00047655-RA	40	KEGG: 00362+4.2.1.17+1.1.1.35;MetaCyc: PWY-1361;KEGG: 00410+4.2.1.17;KEGG: 00592+4.2.1.17;MetaCyc: PWY-5138;MetaCyc: PWY-6944;MetaCyc: PWY-7401;MetaCyc: PWY-5789;KEGG: 00281+4.2.1.17+1.1.1.35;MetaCyc: PWY-5109;MetaCyc: PWY-6583;KEGG: 00720+4.2.1.17+1.1.1.35;MetaCyc: PWY-7656;KEGG: 00640+4.2.1.17;KEGG: 00650+4.2.1.17+1.1.1.35;KEGG: 00930+4.2.1.17+1.1.1.35;MetaCyc: PWY-6435;MetaCyc: PWY-7216;MetaCyc: PWY-7007;KEGG: 00280+4.2.1.17+1.1.1.35;KEGG: 00627+4.2.1.17;MetaCyc: PWY-7606;MetaCyc: PWY-7779;MetaCyc: PWY-5177;KEGG: 00623+1.1.1.35;KEGG: 00071+4.2.1.17+1.1.1.35;MetaCyc: PWY-6946;KEGG: 00380+4.2.1.17+1.1.1.35;KEGG: 00903+4.2.1.17;MetaCyc: PWY-6945;MetaCyc: PWY-6883;KEGG: 00062+4.2.1.17+1.1.1.35;KEGG: 00360+4.2.1.17;MetaCyc: PWY-7726;KEGG: 00310+4.2.1.17+1.1.1.35;MetaCyc: PWY-7778;MetaCyc: PWY-7654;MetaCyc: PWY-5136;MetaCyc: PWY-6863;MetaCyc: PWY-7094	"Benzoate degradation";"Benzoyl-coa degradation I (aerobic)";"beta-Alanine metabolism";"alpha-Linolenic acid metabolism";"Fatty acid beta-oxidation IV (unsaturated, even number)";"Androstenedione degradation";"Crotonate fermentation (to acetate and cyclohexane carboxylate)";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Geraniol degradation";"Fermentation to 2-methylbutanoate";"Pyruvate fermentation to butanol I";"Carbon fixation pathways in prokaryotes";"Spodoptera littoralis pheromone biosynthesis";"Propanoate metabolism";"Butanoate metabolism";"Caprolactam degradation";"4-hydroxybenzoate biosynthesis III (plants)";"(R)- and (S)-3-hydroxybutanoate biosynthesis (engineered)";"Methyl ketone biosynthesis (engineered)";"Valine, leucine and isoleucine degradation";"Aminobenzoate degradation";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Methyl tert-butyl ether degradation";"Glutaryl-coa degradation";"Toluene degradation";"Fatty acid degradation";"Cholesterol degradation to androstenedione II (cholesterol dehydrogenase)";"Tryptophan metabolism";"Limonene and pinene degradation";"Cholesterol degradation to androstenedione I (cholesterol oxidase)";"Pyruvate fermentation to butanol II (engineered)";"Fatty acid elongation";"Phenylalanine metabolism";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"Lysine degradation";"2-methylpropene degradation";"(8E,10E)-dodeca-8,10-dienol biosynthesis";"Fatty acid beta-oxidation II (plant peroxisome)";"Pyruvate fermentation to hexanol (engineered)";"Fatty acid salvage"
Medex_00046605-RA	1	Reactome: R-HSA-1169408	"ISG15 antiviral mechanism"
Medex_00030903-RA	6	Reactome: R-HSA-3299685;Reactome: R-HSA-9615017;KEGG: 00380+1.11.1.6;Reactome: R-HSA-9033241;KEGG: 00630+1.11.1.6;Reactome: R-HSA-6798695	"Detoxification of Reactive Oxygen Species";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"Tryptophan metabolism";"Peroxisomal protein import";"Glyoxylate and dicarboxylate metabolism";"Neutrophil degranulation"
Medex_00029298-RA	6	Reactome: R-HSA-72649;Reactome: R-HSA-72702;Reactome: R-HSA-72695;Reactome: R-HSA-156827;Reactome: R-HSA-72706;Reactome: R-HSA-72689	"Translation initiation complex formation";"Ribosomal scanning and start codon recognition";"Formation of the ternary complex, and subsequently, the 43S complex";"L13a-mediated translational silencing of Ceruloplasmin expression";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Formation of a pool of free 40S subunits"
Medex_00061453-RA	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
Medex_00019758-RA	1	Reactome: R-HSA-5663220	"RHO GTPases Activate Formins"
Medex_00041532-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00019171-RA	1	KEGG: 00970+6.1.1.3	"Aminoacyl-tRNA biosynthesis"
Medex_00004349-RA	3	MetaCyc: PWY-7511;Reactome: R-HSA-983168;Reactome: R-HSA-1358803	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation";"Downregulation of ERBB2:ERBB3 signaling"
Medex_00021566-RA	5	Reactome: R-HSA-5694530;Reactome: R-HSA-1655829;Reactome: R-HSA-204005;Reactome: R-HSA-2132295;Reactome: R-HSA-983170	"Cargo concentration in the ER";"Regulation of cholesterol biosynthesis by SREBP (SREBF)";"COPII-mediated vesicle transport";"MHC class II antigen presentation";"Antigen Presentation: Folding, assembly and peptide loading of class I MHC"
Medex_00026583-RA	13	Reactome: R-HSA-381676;Reactome: R-HSA-5218921;Reactome: R-HSA-5607763;Reactome: R-HSA-5578775;Reactome: R-HSA-114508;Reactome: R-HSA-2871809;Reactome: R-HSA-4086398;Reactome: R-HSA-422356;Reactome: R-HSA-112043;Reactome: R-HSA-2029485;Reactome: R-HSA-983695;Reactome: R-HSA-139853;Reactome: R-HSA-1489509	"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"VEGFR2 mediated cell proliferation";"CLEC7A (Dectin-1) induces NFAT activation";"Ion homeostasis";"Effects of PIP2 hydrolysis";"FCERI mediated Ca+2 mobilization";"Ca2+ pathway";"Regulation of insulin secretion";"PLC beta mediated events";"Role of phospholipids in phagocytosis";"Antigen activates B Cell Receptor (BCR) leading to generation of second messengers";"Elevation of cytosolic Ca2+ levels";"DAG and IP3 signaling"
Medex_00064475-RA	1	Reactome: R-HSA-211981	"Xenobiotics"
Medex_00008198-RA	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
Medex_00042688-RA	27	Reactome: R-HSA-4085377;Reactome: R-HSA-170822;Reactome: R-HSA-4570464;Reactome: R-HSA-180910;Reactome: R-HSA-168271;Reactome: R-HSA-3232142;Reactome: R-HSA-3301854;Reactome: R-HSA-3108214;Reactome: R-HSA-6784531;Reactome: R-HSA-168325;Reactome: R-HSA-159236;Reactome: R-HSA-191859;Reactome: R-HSA-5619107;Reactome: R-HSA-9610379;Reactome: R-HSA-9609690;Reactome: R-HSA-4551638;Reactome: R-HSA-159231;Reactome: R-HSA-180746;Reactome: R-HSA-159227;Reactome: R-HSA-1169408;Reactome: R-HSA-168333;Reactome: R-HSA-165054;Reactome: R-HSA-5578749;Reactome: R-HSA-168276;Reactome: R-HSA-4615885;Reactome: R-HSA-159230;Reactome: R-HSA-3371453	"SUMOylation of SUMOylation proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"SUMOylation of RNA binding proteins";"Vpr-mediated nuclear import of PICs";"Transport of Ribonucleoproteins into the Host Nucleus";"SUMOylation of ubiquitinylation proteins";"Nuclear Pore Complex (NPC) Disassembly";"SUMOylation of DNA damage response and repair proteins";"tRNA processing in the nucleus";"Viral Messenger RNA Synthesis";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"snRNP Assembly";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"HCMV Late Events";"HCMV Early Events";"SUMOylation of chromatin organization proteins";"Transport of Mature mRNA Derived from an Intronless Transcript";"Nuclear import of Rev protein";"Transport of the SLBP independent Mature mRNA";"ISG15 antiviral mechanism";"NEP/NS2 Interacts with the Cellular Export Machinery";"Rev-mediated nuclear export of HIV RNA";"Transcriptional regulation by small RNAs";"NS1 Mediated Effects on Host Pathways";"SUMOylation of DNA replication proteins";"Transport of the SLBP Dependant Mature mRNA";"Regulation of HSF1-mediated heat shock response"
Medex_00011336-RA	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
Medex_00030798-RA	1	Reactome: R-HSA-211981	"Xenobiotics"
Medex_00032027-RA	1	KEGG: 00970+6.3.5.7	"Aminoacyl-tRNA biosynthesis"
Medex_00028609-RA	3	Reactome: R-HSA-192456;KEGG: 00561+3.1.1.3;MetaCyc: PWY-6857	"Digestion of dietary lipid";"Glycerolipid metabolism";"Retinol biosynthesis"
Medex_00095142-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Medex_00014153-RA	4	Reactome: R-HSA-418359;Reactome: R-HSA-1912420;Reactome: R-HSA-5578775;Reactome: R-HSA-936837	"Reduction of cytosolic Ca++ levels";"Pre-NOTCH Processing in Golgi";"Ion homeostasis";"Ion transport by P-type ATPases"
Medex_00054633-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Medex_00065170-RA	1	Reactome: R-HSA-162791	"Attachment of GPI anchor to uPAR"
Medex_00047757-RA	1	Reactome: R-HSA-162791	"Attachment of GPI anchor to uPAR"
Medex_00016557-RA	1	Reactome: R-HSA-71262	"Carnitine synthesis"
Medex_00010940-RA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
Medex_00064080-RA	5	KEGG: 00340+2.1.2.5;Reactome: R-HSA-70921;MetaCyc: PWY-5497;KEGG: 00670+4.3.1.4+2.1.2.5;MetaCyc: PWY-5030	"Histidine metabolism";"Histidine catabolism";"Purine nucleobases degradation II (anaerobic)";"One carbon pool by folate";"L-histidine degradation III"
Medex_00025777-RA	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
Medex_00096770-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Medex_00012342-RA	3	Reactome: R-HSA-936837;Reactome: R-HSA-5578775;Reactome: R-HSA-418359	"Ion transport by P-type ATPases";"Ion homeostasis";"Reduction of cytosolic Ca++ levels"
Medex_00032069-RA	3	Reactome: R-HSA-1445148;Reactome: R-HSA-5620916;Reactome: R-HSA-264876	"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"VxPx cargo-targeting to cilium";"Insulin processing"
Medex_00006593-RA	5	Reactome: R-HSA-5221030;Reactome: R-HSA-110328;Reactome: R-HSA-3108214;Reactome: R-HSA-110329;Reactome: R-HSA-110357	"TET1,2,3 and TDG demethylate DNA";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"SUMOylation of DNA damage response and repair proteins";"Cleavage of the damaged pyrimidine";"Displacement of DNA glycosylase by APEX1"
Medex_00048221-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Medex_00031295-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Medex_00064716-RA	4	KEGG: 00270+2.1.1.37;Reactome: R-HSA-5334118;Reactome: R-HSA-212300;Reactome: R-HSA-4655427	"Cysteine and methionine metabolism";"DNA methylation";"PRC2 methylates histones and DNA";"SUMOylation of DNA methylation proteins"
Medex_00030718-RA	6	Reactome: R-HSA-5693616;Reactome: R-HSA-176187;Reactome: R-HSA-6804756;Reactome: R-HSA-5685938;Reactome: R-HSA-69473;Reactome: R-HSA-5693607	"Presynaptic phase of homologous DNA pairing and strand exchange";"Activation of ATR in response to replication stress";"Regulation of TP53 Activity through Phosphorylation";"HDR through Single Strand Annealing (SSA)";"G2/M DNA damage checkpoint";"Processing of DNA double-strand break ends"
Medex_00062606-RA	12	Reactome: R-HSA-381038;Reactome: R-HSA-380284;Reactome: R-HSA-380270;Reactome: R-HSA-380259;Reactome: R-HSA-6807878;Reactome: R-HSA-6811436;Reactome: R-HSA-5620912;Reactome: R-HSA-380320;Reactome: R-HSA-8854518;Reactome: R-HSA-2565942;Reactome: R-HSA-2132295;Reactome: R-HSA-3371497	"XBP1(S) activates chaperone genes";"Loss of proteins required for interphase microtubule organization from the centrosome";"Recruitment of mitotic centrosome proteins and complexes";"Loss of Nlp from mitotic centrosomes";"COPI-mediated anterograde transport";"COPI-independent Golgi-to-ER retrograde traffic";"Anchoring of the basal body to the plasma membrane";"Recruitment of NuMA to mitotic centrosomes";"AURKA Activation by TPX2";"Regulation of PLK1 Activity at G2/M Transition";"MHC class II antigen presentation";"HSP90 chaperone cycle for steroid hormone receptors (SHR)"
Medex_00059935-RA	1	Reactome: R-HSA-428890	"Role of ABL in ROBO-SLIT signaling"
Medex_00028628-RA	14	MetaCyc: PWY-2221;MetaCyc: PWY-6886;MetaCyc: PWY-5723;MetaCyc: PWY-1042;MetaCyc: PWY-1622;MetaCyc: PWY-7003;MetaCyc: PWY-6142;MetaCyc: PWY-6901;KEGG: 00010+4.2.1.11;MetaCyc: PWY-7124;KEGG: 00680+4.2.1.11;MetaCyc: PWY-8004;MetaCyc: PWY-7218;MetaCyc: PWY-5484	"Entner-Doudoroff pathway III (semi-phosphorylative)";"1-butanol autotrophic biosynthesis (engineered)";"Rubisco shunt";"Glycolysis IV (plant cytosol)";"Formaldehyde assimilation I (serine pathway)";"Glycerol degradation to butanol";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Superpathway of glucose and xylose degradation";"Glycolysis / Gluconeogenesis";"Ethylene biosynthesis V (engineered)";"Methane metabolism";"Entner-Doudoroff pathway I";"Photosynthetic 3-hydroxybutanoate biosynthesis (engineered)";"Glycolysis II (from fructose 6-phosphate)"
Medex_00066912-RA	2	Reactome: R-HSA-373080;Reactome: R-HSA-3238698	"Class B/2 (Secretin family receptors)";"WNT ligand biogenesis and trafficking"
Medex_00056739-RA	7	Reactome: R-HSA-1362277;Reactome: R-HSA-6804114;Reactome: R-HSA-1538133;Reactome: R-HSA-2173796;Reactome: R-HSA-69231;Reactome: R-HSA-1362300;Reactome: R-HSA-69205	"Transcription of E2F targets under negative control by DREAM complex";"TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest";"G0 and Early G1";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"Cyclin D associated events in G1";"Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1";"G1/S-Specific Transcription"
Medex_00041429-RA	5	KEGG: 00534+2.4.1.224+2.4.1.225;Reactome: R-HSA-3656237;MetaCyc: PWY-6558;Reactome: R-HSA-2022928;Reactome: R-HSA-3656253	"Glycosaminoglycan biosynthesis - heparan sulfate / heparin";"Defective EXT2 causes exostoses 2";"Heparan sulfate biosynthesis (late stages)";"HS-GAG biosynthesis";"Defective EXT1 causes exostoses 1, TRPS2 and CHDS"
Medex_00051130-RA	5	Reactome: R-HSA-1650814;Reactome: R-HSA-2214320;Reactome: R-HSA-1474228;Reactome: R-HSA-2243919;Reactome: R-HSA-8963896	"Collagen biosynthesis and modifying enzymes";"Anchoring fibril formation";"Degradation of the extracellular matrix";"Crosslinking of collagen fibrils";"HDL assembly"
Medex_00033219-RA	1	Reactome: R-HSA-4085001	"Sialic acid metabolism"
Medex_00003010-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Medex_00030883-RA	7	MetaCyc: PWY-5469;MetaCyc: PWY-5461;MetaCyc: PWY-6824;KEGG: 00940+1.11.1.7;MetaCyc: PWY-5466;MetaCyc: PWY-7214;MetaCyc: PWY-7445	"Sesamin biosynthesis";"Betanidin degradation";"Justicidin B biosynthesis";"Phenylpropanoid biosynthesis";"Matairesinol biosynthesis";"Baicalein degradation (hydrogen peroxide detoxification)";"Luteolin triglucuronide degradation"
Medex_00023949-RA	18	MetaCyc: PWY-7115;MetaCyc: PWY-7383;MetaCyc: PWY-6638;MetaCyc: PWY-6642;KEGG: 00220+2.6.1.1;KEGG: 00350+2.6.1.1;KEGG: 00360+2.6.1.1;KEGG: 00270+2.6.1.1;MetaCyc: PWY-6643;MetaCyc: PWY-5913;KEGG: 00250+2.6.1.1;MetaCyc: PWY-7117;KEGG: 00710+2.6.1.1;KEGG: 00330+2.6.1.1;KEGG: 00960+2.6.1.1;KEGG: 00400+2.6.1.1;KEGG: 00401+2.6.1.1;KEGG: 00950+2.6.1.1	"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"Anaerobic energy metabolism (invertebrates, cytosol)";"Sulfolactate degradation III";"(R)-cysteate degradation";"Arginine biosynthesis";"Tyrosine metabolism";"Phenylalanine metabolism";"Cysteine and methionine metabolism";"Coenzyme M biosynthesis II";"Partial TCA cycle (obligate autotrophs)";"Alanine, aspartate and glutamate metabolism";"C4 photosynthetic carbon assimilation cycle, PEPCK type";"Carbon fixation in photosynthetic organisms";"Arginine and proline metabolism";"Tropane, piperidine and pyridine alkaloid biosynthesis";"Phenylalanine, tyrosine and tryptophan biosynthesis";"Novobiocin biosynthesis";"Isoquinoline alkaloid biosynthesis"
Medex_00046578-RA	6	Reactome: R-HSA-72702;Reactome: R-HSA-72649;Reactome: R-HSA-156827;Reactome: R-HSA-72695;Reactome: R-HSA-72706;Reactome: R-HSA-72689	"Ribosomal scanning and start codon recognition";"Translation initiation complex formation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Formation of the ternary complex, and subsequently, the 43S complex";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Formation of a pool of free 40S subunits"
Medex_00063045-RA	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
Medex_00010269-RA	4	Reactome: R-HSA-6782135;Reactome: R-HSA-6781823;Reactome: R-HSA-6781827;Reactome: R-HSA-6782210	"Dual incision in TC-NER";"Formation of TC-NER Pre-Incision Complex";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Gap-filling DNA repair synthesis and ligation in TC-NER"
Medex_00062335-RA	3	Reactome: R-HSA-140837;Reactome: R-HSA-9645722;Reactome: R-HSA-111471	"Intrinsic Pathway of Fibrin Clot Formation";"Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function";"Apoptotic factor-mediated response"
Medex_00059393-RA	1	Reactome: R-HSA-204005	"COPII-mediated vesicle transport"
Medex_00037295-RA	2	Reactome: R-HSA-379716;Reactome: R-HSA-2408522	"Cytosolic tRNA aminoacylation";"Selenoamino acid metabolism"
Medex_00011497-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00025995-RA	3	Reactome: R-HSA-110357;Reactome: R-HSA-110329;Reactome: R-HSA-110328	"Displacement of DNA glycosylase by APEX1";"Cleavage of the damaged pyrimidine";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine"
Medex_00092348-RA	7	KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1	"Human papillomavirus infection";"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Human cytomegalovirus infection";"Thermogenesis";"Relaxin signaling pathway"
Medex_00036132-RA	1	Reactome: R-HSA-1474228	"Degradation of the extracellular matrix"
Medex_00021237-RA	1	Reactome: R-HSA-432722	"Golgi Associated Vesicle Biogenesis"
Medex_00050940-RA	4	KEGG: 00562+1.13.99.1;Reactome: R-HSA-1855183;KEGG: 00053+1.13.99.1;MetaCyc: PWY-4841	"Inositol phosphate metabolism";"Synthesis of IP2, IP, and Ins in the cytosol";"Ascorbate and aldarate metabolism";"UDP-alpha-D-glucuronate biosynthesis (from myo-inositol)"
Medex_00055851-RA	3	Reactome: R-HSA-2029482;Reactome: R-HSA-4420097;Reactome: R-HSA-5663213	"Regulation of actin dynamics for phagocytic cup formation";"VEGFA-VEGFR2 Pathway";"RHO GTPases Activate WASPs and WAVEs"
Medex_00057918-RA	4	Reactome: R-HSA-189483;Reactome: R-HSA-382556;Reactome: R-HSA-5679001;MetaCyc: PWY-6972	"Heme degradation";"ABC-family proteins mediated transport";"Defective ABCC2 causes Dubin-Johnson syndrome";"Oleandomycin activation/inactivation"
Medex_00049559-RA	1	Reactome: R-HSA-163765	"ChREBP activates metabolic gene expression"
Medex_00065880-RA	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
Medex_00044336-RA	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
Medex_00008668-RA	1	Reactome: R-HSA-211981	"Xenobiotics"
Medex_00005257-RA	1	Reactome: R-HSA-6811440	"Retrograde transport at the Trans-Golgi-Network"
Medex_00047905-RA	1	Reactome: R-HSA-5620912	"Anchoring of the basal body to the plasma membrane"
Medex_00039717-RA	1	Reactome: R-HSA-373753	"Nephrin family interactions"
Medex_00021752-RA	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
Medex_00025005-RA	2	Reactome: R-HSA-8951664;Reactome: R-HSA-983168	"Neddylation";"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00063334-RA	12	Reactome: R-HSA-75955;Reactome: R-HSA-167238;Reactome: R-HSA-6796648;Reactome: R-HSA-112382;Reactome: R-HSA-167246;Reactome: R-HSA-6804756;Reactome: R-HSA-167200;Reactome: R-HSA-167290;Reactome: R-HSA-674695;Reactome: R-HSA-167152;Reactome: R-HSA-167287;Reactome: R-HSA-167243	"RNA Polymerase II Transcription Elongation";"Pausing and recovery of Tat-mediated HIV elongation";"TP53 Regulates Transcription of DNA Repair Genes";"Formation of RNA Pol II elongation complex";"Tat-mediated elongation of the HIV-1 transcript";"Regulation of TP53 Activity through Phosphorylation";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Pausing and recovery of HIV elongation";"RNA Polymerase II Pre-transcription Events";"Formation of HIV elongation complex in the absence of HIV Tat";"HIV elongation arrest and recovery";"Tat-mediated HIV elongation arrest and recovery"
Medex_00088683-RA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
Medex_00042925-RA	1	Reactome: R-HSA-390522	"Striated Muscle Contraction"
Medex_00040519-RA	3	Reactome: R-HSA-212436;Reactome: R-HSA-1989781;Reactome: R-HSA-381340	"Generic Transcription Pathway";"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation"
Medex_00020355-RA	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00047754-RA	1	Reactome: R-HSA-6784531	"tRNA processing in the nucleus"
Medex_00012875-RA	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840	"Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation"
Medex_00082610-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00030878-RA	1	Reactome: R-HSA-5617833	"Cilium Assembly"
Medex_00094031-RA	7	KEGG: 00720+6.3.4.3;MetaCyc: PWY-2201;Reactome: R-HSA-196757;MetaCyc: PWY-1722;MetaCyc: PWY-3841;KEGG: 00670+6.3.4.3;MetaCyc: PWY-2161	"Carbon fixation pathways in prokaryotes";"Folate transformations I";"Metabolism of folate and pterines";"Formate assimilation into 5,10-methylenetetrahydrofolate";"Folate transformations II (plants)";"One carbon pool by folate";"Folate polyglutamylation"
Medex_00011976-RA	27	Reactome: R-HSA-5578749;Reactome: R-HSA-168276;Reactome: R-HSA-3371453;Reactome: R-HSA-4615885;Reactome: R-HSA-159230;Reactome: R-HSA-180746;Reactome: R-HSA-159227;Reactome: R-HSA-159231;Reactome: R-HSA-165054;Reactome: R-HSA-1169408;Reactome: R-HSA-168333;Reactome: R-HSA-168325;Reactome: R-HSA-191859;Reactome: R-HSA-159236;Reactome: R-HSA-3108214;Reactome: R-HSA-6784531;Reactome: R-HSA-4551638;Reactome: R-HSA-9609690;Reactome: R-HSA-9610379;Reactome: R-HSA-5619107;Reactome: R-HSA-170822;Reactome: R-HSA-4570464;Reactome: R-HSA-4085377;Reactome: R-HSA-3232142;Reactome: R-HSA-3301854;Reactome: R-HSA-168271;Reactome: R-HSA-180910	"Transcriptional regulation by small RNAs";"NS1 Mediated Effects on Host Pathways";"Regulation of HSF1-mediated heat shock response";"SUMOylation of DNA replication proteins";"Transport of the SLBP Dependant Mature mRNA";"Nuclear import of Rev protein";"Transport of the SLBP independent Mature mRNA";"Transport of Mature mRNA Derived from an Intronless Transcript";"Rev-mediated nuclear export of HIV RNA";"ISG15 antiviral mechanism";"NEP/NS2 Interacts with the Cellular Export Machinery";"Viral Messenger RNA Synthesis";"snRNP Assembly";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"SUMOylation of DNA damage response and repair proteins";"tRNA processing in the nucleus";"SUMOylation of chromatin organization proteins";"HCMV Early Events";"HCMV Late Events";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"SUMOylation of RNA binding proteins";"SUMOylation of SUMOylation proteins";"SUMOylation of ubiquitinylation proteins";"Nuclear Pore Complex (NPC) Disassembly";"Transport of Ribonucleoproteins into the Host Nucleus";"Vpr-mediated nuclear import of PICs"
Medex_00086951-RA	5	Reactome: R-HSA-390471;Reactome: R-HSA-390450;Reactome: R-HSA-389960;Reactome: R-HSA-6814122;Reactome: R-HSA-389957	"Association of TriC/CCT with target proteins during biosynthesis";"Folding of actin by CCT/TriC";"Formation of tubulin folding intermediates by CCT/TriC";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"Prefoldin mediated transfer of substrate to CCT/TriC"
Medex_00021033-RA	1	Reactome: R-HSA-611105	"Respiratory electron transport"
Medex_00029928-RA	3	Reactome: R-HSA-5663220;Reactome: R-HSA-6785631;Reactome: R-HSA-6798695	"RHO GTPases Activate Formins";"ERBB2 Regulates Cell Motility";"Neutrophil degranulation"
Medex_00017816-RA	1	Reactome: R-HSA-8856828	"Clathrin-mediated endocytosis"
Medex_00006438-RA	1	Reactome: R-HSA-429958	"mRNA decay by 3' to 5' exoribonuclease"
Medex_00041441-RA	3	KEGG: 00730+3.1.3.1;KEGG: 00790+3.1.3.1;MetaCyc: PWY-5491	"Thiamine metabolism";"Folate biosynthesis";"Diethylphosphate degradation"
Medex_00068417-RA	3	Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-212436	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"Generic Transcription Pathway"
Medex_00004694-RA	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
Medex_00010460-RA	13	Reactome: R-HSA-416993;Reactome: R-HSA-437239;Reactome: R-HSA-5099900;Reactome: R-HSA-8964038;Reactome: R-HSA-2132295;Reactome: R-HSA-8856828;Reactome: R-HSA-167590;Reactome: R-HSA-182218;Reactome: R-HSA-3928665;Reactome: R-HSA-5140745;Reactome: R-HSA-177504;Reactome: R-HSA-8856825;Reactome: R-HSA-8866427	"Trafficking of GluR2-containing AMPA receptors";"Recycling pathway of L1";"WNT5A-dependent internalization of FZD4";"LDL clearance";"MHC class II antigen presentation";"Clathrin-mediated endocytosis";"Nef Mediated CD4 Down-regulation";"Nef Mediated CD8 Down-regulation";"EPH-ephrin mediated repulsion of cells";"WNT5A-dependent internalization of FZD2, FZD5 and ROR2";"Retrograde neurotrophin signalling";"Cargo recognition for clathrin-mediated endocytosis";"VLDLR internalisation and degradation"
Medex_00043912-RA	6	KEGG: 00052+3.2.1.23;KEGG: 00531+3.2.1.23;KEGG: 00604+3.2.1.23;MetaCyc: PWY-6807;KEGG: 00511+3.2.1.23;KEGG: 00600+3.2.1.23	"Galactose metabolism";"Glycosaminoglycan degradation";"Glycosphingolipid biosynthesis - ganglio series";"Xyloglucan degradation II (exoglucanase)";"Other glycan degradation";"Sphingolipid metabolism"
Medex_00015894-RA	1	Reactome: R-HSA-2132295	"MHC class II antigen presentation"
Medex_00000221-RA	1	Reactome: R-HSA-5576886	"Phase 4 - resting membrane potential"
Medex_00025090-RA	2	Reactome: R-HSA-5576893;Reactome: R-HSA-5576892	"Phase 2 - plateau phase";"Phase 0 - rapid depolarisation"
Medex_00029297-RA	6	Reactome: R-HSA-72689;Reactome: R-HSA-72706;Reactome: R-HSA-72695;Reactome: R-HSA-156827;Reactome: R-HSA-72649;Reactome: R-HSA-72702	"Formation of a pool of free 40S subunits";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Formation of the ternary complex, and subsequently, the 43S complex";"L13a-mediated translational silencing of Ceruloplasmin expression";"Translation initiation complex formation";"Ribosomal scanning and start codon recognition"
Medex_00035489-RA	1	Reactome: R-HSA-6784531	"tRNA processing in the nucleus"
Medex_00047050-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Medex_00033922-RA	6	KEGG: 00230+3.5.4.10+2.1.2.3;MetaCyc: PWY-6123;MetaCyc: PWY-6124;KEGG: 00670+2.1.2.3;Reactome: R-HSA-73817;MetaCyc: PWY-7234	"Purine metabolism";"Inosine-5'-phosphate biosynthesis I";"Inosine-5'-phosphate biosynthesis II";"One carbon pool by folate";"Purine ribonucleoside monophosphate biosynthesis";"Inosine-5'-phosphate biosynthesis III"
Medex_00016148-RA	1	Reactome: R-HSA-8951664	"Neddylation"
Medex_00034598-RA	1	Reactome: R-HSA-1445148	"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
Medex_00065329-RA	27	Reactome: R-HSA-168276;Reactome: R-HSA-5578749;Reactome: R-HSA-3371453;Reactome: R-HSA-159230;Reactome: R-HSA-4615885;Reactome: R-HSA-159227;Reactome: R-HSA-180746;Reactome: R-HSA-159231;Reactome: R-HSA-165054;Reactome: R-HSA-168333;Reactome: R-HSA-1169408;Reactome: R-HSA-191859;Reactome: R-HSA-159236;Reactome: R-HSA-168325;Reactome: R-HSA-6784531;Reactome: R-HSA-3108214;Reactome: R-HSA-9609690;Reactome: R-HSA-4551638;Reactome: R-HSA-9610379;Reactome: R-HSA-5619107;Reactome: R-HSA-4570464;Reactome: R-HSA-170822;Reactome: R-HSA-4085377;Reactome: R-HSA-3301854;Reactome: R-HSA-3232142;Reactome: R-HSA-168271;Reactome: R-HSA-180910	"NS1 Mediated Effects on Host Pathways";"Transcriptional regulation by small RNAs";"Regulation of HSF1-mediated heat shock response";"Transport of the SLBP Dependant Mature mRNA";"SUMOylation of DNA replication proteins";"Transport of the SLBP independent Mature mRNA";"Nuclear import of Rev protein";"Transport of Mature mRNA Derived from an Intronless Transcript";"Rev-mediated nuclear export of HIV RNA";"NEP/NS2 Interacts with the Cellular Export Machinery";"ISG15 antiviral mechanism";"snRNP Assembly";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Viral Messenger RNA Synthesis";"tRNA processing in the nucleus";"SUMOylation of DNA damage response and repair proteins";"HCMV Early Events";"SUMOylation of chromatin organization proteins";"HCMV Late Events";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"SUMOylation of RNA binding proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"SUMOylation of SUMOylation proteins";"Nuclear Pore Complex (NPC) Disassembly";"SUMOylation of ubiquitinylation proteins";"Transport of Ribonucleoproteins into the Host Nucleus";"Vpr-mediated nuclear import of PICs"
Medex_00025600-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Medex_00041663-RA	41	Reactome: R-HSA-190375;Reactome: R-HSA-5655302;Reactome: R-HSA-190377;Reactome: R-HSA-5654710;Reactome: R-HSA-6811558;Reactome: R-HSA-5654699;Reactome: R-HSA-109704;Reactome: R-HSA-1257604;Reactome: R-HSA-5654727;Reactome: R-HSA-8853338;Reactome: R-HSA-5654228;Reactome: R-HSA-190370;Reactome: R-HSA-190372;Reactome: R-HSA-5673001;Reactome: R-HSA-5654700;Reactome: R-HSA-5654695;Reactome: R-HSA-5655253;Reactome: R-HSA-1839122;Reactome: R-HSA-1839130;Reactome: R-HSA-8851708;Reactome: R-HSA-5654732;Reactome: R-HSA-5654704;Reactome: R-HSA-5654219;Reactome: R-HSA-2033519;Reactome: R-HSA-2033514;Reactome: R-HSA-5654706;Reactome: R-HSA-5654733;Reactome: R-HSA-2219530;Reactome: R-HSA-5654719;Reactome: R-HSA-5654726;Reactome: R-HSA-5654720;Reactome: R-HSA-5654227;Reactome: R-HSA-5654712;Reactome: R-HSA-5654221;Reactome: R-HSA-5654688;Reactome: R-HSA-5654693;Reactome: R-HSA-190322;Reactome: R-HSA-190371;Reactome: R-HSA-5654687;Reactome: R-HSA-190373;Reactome: R-HSA-5654689	"FGFR2c ligand binding and activation";"Signaling by FGFR1 in disease";"FGFR2b ligand binding and activation";"PI-3K cascade:FGFR3";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"SHC-mediated cascade:FGFR2";"PI3K Cascade";"PIP3 activates AKT signaling";"Negative regulation of FGFR2 signaling";"Signaling by FGFR3 point mutants in cancer";"Phospholipase C-mediated cascade, FGFR4";"FGFR1b ligand binding and activation";"FGFR3c ligand binding and activation";"RAF/MAP kinase cascade";"FRS-mediated FGFR2 signaling";"PI-3K cascade:FGFR2";"Signaling by FGFR2 in disease";"Signaling by activated point mutants of FGFR1";"Signaling by activated point mutants of FGFR3";"Signaling by FGFR2 IIIa TM";"Negative regulation of FGFR3 signaling";"SHC-mediated cascade:FGFR3";"Phospholipase C-mediated cascade: FGFR1";"Activated point mutants of FGFR2";"FGFR3 mutant receptor activation";"FRS-mediated FGFR3 signaling";"Negative regulation of FGFR4 signaling";"Constitutive Signaling by Aberrant PI3K in Cancer";"SHC-mediated cascade:FGFR4";"Negative regulation of FGFR1 signaling";"PI-3K cascade:FGFR4";"Phospholipase C-mediated cascade, FGFR3";"FRS-mediated FGFR4 signaling";"Phospholipase C-mediated cascade, FGFR2";"SHC-mediated cascade:FGFR1";"FRS-mediated FGFR1 signaling";"FGFR4 ligand binding and activation";"FGFR3b ligand binding and activation";"Downstream signaling of activated FGFR1";"FGFR1c ligand binding and activation";"PI-3K cascade:FGFR1"
Medex_00058682-RA	3	KEGG: 00232+1.7.3.3;KEGG: 00230+1.7.3.3;MetaCyc: PWY-5691	"Caffeine metabolism";"Purine metabolism";"Urate conversion to allantoin I"
Medex_00015388-RA	9	Reactome: R-HSA-5674135;Reactome: R-HSA-6802948;Reactome: R-HSA-6798695;Reactome: R-HSA-445355;Reactome: R-HSA-6802955;Reactome: R-HSA-6802952;Reactome: R-HSA-114608;Reactome: R-HSA-6802946;Reactome: R-HSA-9649948	"MAP2K and MAPK activation";"Signaling by high-kinase activity BRAF mutants";"Neutrophil degranulation";"Smooth Muscle Contraction";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"Signaling by BRAF and RAF fusions";"Platelet degranulation";"Signaling by moderate kinase activity BRAF mutants";"Signaling downstream of RAS mutants"
Medex_00088060-RA	1	Reactome: R-HSA-2514859	"Inactivation, recovery and regulation of the phototransduction cascade"
Medex_00072668-RA	10	MetaCyc: PWY-7419;MetaCyc: PWY-7769;MetaCyc: PWY-7510;MetaCyc: PWY-6839;KEGG: 00440+5.4.2.9;MetaCyc: PWY-6682;MetaCyc: PWY-5757;MetaCyc: PWY-8067;KEGG: 00998+5.4.2.9;MetaCyc: PWY-6322	"FR-900098 and FR-33289 antibiotics biosynthesis";"Phosalacine biosynthesis";"Rhizocticin A and B biosynthesis";"2-aminoethylphosphonate biosynthesis";"Phosphonate and phosphinate metabolism";"Dehydrophos biosynthesis";"Fosfomycin biosynthesis";"Methylphosphonate biosynthesis";"Biosynthesis of various secondary metabolites - part 2";"Phosphinothricin tripeptide biosynthesis"
Medex_00002386-RA	1	Reactome: R-HSA-432722	"Golgi Associated Vesicle Biogenesis"
Medex_00072438-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Medex_00032426-RA	5	MetaCyc: PWY-8043;KEGG: 00480+6.3.2.3;Reactome: R-HSA-5579006;Reactome: R-HSA-174403;KEGG: 00270+6.3.2.3	"Ophthalmate biosynthesis";"Glutathione metabolism";"Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)";"Glutathione synthesis and recycling";"Cysteine and methionine metabolism"
Medex_00036992-RA	2	Reactome: R-HSA-3371599;Reactome: R-HSA-196780	"Defective HLCS causes multiple carboxylase deficiency";"Biotin transport and metabolism"
Medex_00056028-RA	3	Reactome: R-HSA-6811440;Reactome: R-HSA-6807878;Reactome: R-HSA-6811438	"Retrograde transport at the Trans-Golgi-Network";"COPI-mediated anterograde transport";"Intra-Golgi traffic"
Medex_00034161-RA	2	Reactome: R-HSA-3214841;Reactome: R-HSA-8936459	"PKMTs methylate histone lysines";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"
Medex_00091524-RA	1	Reactome: R-HSA-901032	"ER Quality Control Compartment (ERQC)"
Medex_00054927-RA	1	Reactome: R-HSA-2468052	"Establishment of Sister Chromatid Cohesion"
Medex_00081944-RA	11	Reactome: R-HSA-1251985;Reactome: R-HSA-2894862;Reactome: R-HSA-9017802;Reactome: R-HSA-2122948;Reactome: R-HSA-9013507;Reactome: R-HSA-205043;Reactome: R-HSA-193692;Reactome: R-HSA-9013700;Reactome: R-HSA-2979096;Reactome: R-HSA-2644606;Reactome: R-HSA-3928665	"Nuclear signaling by ERBB4";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Noncanonical activation of NOTCH3";"Activated NOTCH1 Transmits Signal to the Nucleus";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"NRIF signals cell death from the nucleus";"Regulated proteolysis of p75NTR";"NOTCH4 Activation and Transmission of Signal to the Nucleus";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"EPH-ephrin mediated repulsion of cells"
Medex_00035614-RA	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
Medex_00069333-RA	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
Medex_00004058-RA	2	Reactome: R-HSA-1483115;Reactome: R-HSA-1483152	"Hydrolysis of LPC";"Hydrolysis of LPE"
Medex_00019131-RA	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
Medex_00058992-RA	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
Medex_00046893-RA	6	MetaCyc: PWY-5884;Reactome: R-HSA-9640463;MetaCyc: PWY-7782;MetaCyc: PWY-7656;MetaCyc: PWY-6733;KEGG: 00073+1.2.1.84	"Wax esters biosynthesis I";"Wax biosynthesis";"Plasmalogen biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Sporopollenin precursors biosynthesis";"Cutin, suberine and wax biosynthesis"
Medex_00067981-RA	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
Medex_00036019-RA	5	MetaCyc: PWY-6527;KEGG: 00561+3.2.1.22;KEGG: 00052+3.2.1.22;KEGG: 00600+3.2.1.22;KEGG: 00603+3.2.1.22	"Stachyose degradation";"Glycerolipid metabolism";"Galactose metabolism";"Sphingolipid metabolism";"Glycosphingolipid biosynthesis - globo and isoglobo series"
Medex_00001707-RA	3	KEGG: 00730+3.1.3.2;KEGG: 00740+3.1.3.2;MetaCyc: PWY-6348	"Thiamine metabolism";"Riboflavin metabolism";"Phosphate acquisition"
Medex_00061981-RA	2	MetaCyc: PWY-6281;KEGG: 00450+2.7.9.3	"L-selenocysteine biosynthesis II (archaea and eukaryotes)";"Selenocompound metabolism"
Medex_00033493-RA	1	Reactome: R-HSA-2132295	"MHC class II antigen presentation"
Medex_00011902-RA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Medex_00054444-RA	1	Reactome: R-HSA-1474228	"Degradation of the extracellular matrix"
Medex_00022232-RA	6	MetaCyc: PWY-5664;MetaCyc: PWY-6983;Reactome: R-HSA-1474151;KEGG: 00790+4.2.3.12;MetaCyc: PWY-7442;MetaCyc: PWY-5663	"Erythro-tetrahydrobiopterin biosynthesis II";"Threo-tetrahydrobiopterin biosynthesis";"Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation";"Folate biosynthesis";"Drosopterin and aurodrosopterin biosynthesis";"Erythro-tetrahydrobiopterin biosynthesis I"
Medex_00035466-RA	7	MetaCyc: PWY-7214;MetaCyc: PWY-5466;MetaCyc: PWY-7445;KEGG: 00940+1.11.1.7;MetaCyc: PWY-5461;MetaCyc: PWY-6824;MetaCyc: PWY-5469	"Baicalein degradation (hydrogen peroxide detoxification)";"Matairesinol biosynthesis";"Luteolin triglucuronide degradation";"Phenylpropanoid biosynthesis";"Betanidin degradation";"Justicidin B biosynthesis";"Sesamin biosynthesis"
Medex_00016892-RA	1	Reactome: R-HSA-1234174	"Cellular response to hypoxia"
Medex_00083901-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00044092-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Medex_00070680-RA	5	Reactome: R-HSA-5610785;Reactome: R-HSA-5610783;Reactome: R-HSA-5610780;Reactome: R-HSA-5610787;Reactome: R-HSA-5632684	"GLI3 is processed to GLI3R by the proteasome";"Degradation of GLI2 by the proteasome";"Degradation of GLI1 by the proteasome";"Hedgehog 'off' state";"Hedgehog 'on' state"
Medex_00064754-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Medex_00076521-RA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
Medex_00003872-RA	11	MetaCyc: PWY-7560;MetaCyc: PWY-7102;MetaCyc: PWY-5123;MetaCyc: PWY-7524;KEGG: 00900+5.3.3.2;MetaCyc: PWY-922;MetaCyc: PWY-6859;MetaCyc: PWY-7391;MetaCyc: PWY-6174;Reactome: R-HSA-191273;MetaCyc: PWY-6383	"Methylerythritol phosphate pathway II";"Bisabolene biosynthesis (engineered)";"Trans, trans-farnesyl diphosphate biosynthesis";"Mevalonate pathway III (archaea)";"Terpenoid backbone biosynthesis";"Mevalonate pathway I";"All-trans-farnesol biosynthesis";"Isoprene biosynthesis II (engineered)";"Mevalonate pathway II (archaea)";"Cholesterol biosynthesis";"Mono-trans, poly-cis decaprenyl phosphate biosynthesis"
Medex_00051862-RA	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
Medex_00039214-RA	3	KEGG: 00740+3.1.3.2;KEGG: 00730+3.1.3.2;MetaCyc: PWY-6348	"Riboflavin metabolism";"Thiamine metabolism";"Phosphate acquisition"
Medex_00046391-RA	5	Reactome: R-HSA-6804758;Reactome: R-HSA-3214815;Reactome: R-HSA-73762;Reactome: R-HSA-427389;Reactome: R-HSA-8943724	"Regulation of TP53 Activity through Acetylation";"HDACs deacetylate histones";"RNA Polymerase I Transcription Initiation";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"Regulation of PTEN gene transcription"
Medex_00056419-RA	2	Reactome: R-HSA-383280;Reactome: R-HSA-4090294	"Nuclear Receptor transcription pathway";"SUMOylation of intracellular receptors"
Medex_00087262-RA	7	MetaCyc: PWY-6737;MetaCyc: PWY-5941;KEGG: 00500+2.4.1.25;MetaCyc: PWY-6724;Reactome: R-HSA-70221;MetaCyc: PWY-7238;Reactome: R-HSA-6798695	"Starch degradation V";"Glycogen degradation II";"Starch and sucrose metabolism";"Starch degradation II";"Glycogen breakdown (glycogenolysis)";"Sucrose biosynthesis II";"Neutrophil degranulation"
Medex_00040130-RA	1	Reactome: R-HSA-6798163	"Choline catabolism"
Medex_00042983-RA	7	KEGG: 00020+1.2.4.1;Reactome: R-HSA-389661;Reactome: R-HSA-70268;Reactome: R-HSA-204174;KEGG: 00010+1.2.4.1;Reactome: R-HSA-5362517;KEGG: 00620+1.2.4.1	"Citrate cycle (TCA cycle)";"Glyoxylate metabolism and glycine degradation";"Pyruvate metabolism";"Regulation of pyruvate dehydrogenase (PDH) complex";"Glycolysis / Gluconeogenesis";"Signaling by Retinoic Acid";"Pyruvate metabolism"
Medex_00096968-RA	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
Medex_00021727-RA	3	KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16	"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
Medex_00024026-RA	3	KEGG: 00190+7.1.2.2;KEGG: 00195+7.1.2.2;MetaCyc: PWY-7980	"Oxidative phosphorylation";"Photosynthesis";"ATP biosynthesis"
Medex_00047758-RA	22	Reactome: R-HSA-6798695;Reactome: R-HSA-5628897;MetaCyc: PWY-5514;MetaCyc: PWY-8013;MetaCyc: PWY-6992;MetaCyc: PWY-622;KEGG: 00500+5.3.1.9;MetaCyc: PWY-6142;MetaCyc: PWY-621;MetaCyc: PWY-3801;KEGG: 00010+5.3.1.9;MetaCyc: PWY-7238;MetaCyc: PWY-5384;KEGG: 00030+5.3.1.9;MetaCyc: PWY-7347;MetaCyc: PWY-7385;MetaCyc: PWY-6981;KEGG: 00520+5.3.1.9;MetaCyc: PWY-5659;MetaCyc: PWY-5054;Reactome: R-HSA-70171;Reactome: R-HSA-70263	"Neutrophil degranulation";"TP53 Regulates Metabolic Genes";"UDP-N-acetyl-D-galactosamine biosynthesis II";"UDP-N-acetyl-D-galactosamine biosynthesis III";"1,5-anhydrofructose degradation";"Starch biosynthesis";"Starch and sucrose metabolism";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Sucrose degradation III (sucrose invertase)";"Sucrose degradation II (sucrose synthase)";"Glycolysis / Gluconeogenesis";"Sucrose biosynthesis II";"Sucrose degradation IV (sucrose phosphorylase)";"Pentose phosphate pathway";"Sucrose biosynthesis III";"1,3-propanediol biosynthesis (engineered)";"Chitin biosynthesis";"Amino sugar and nucleotide sugar metabolism";"GDP-mannose biosynthesis";"D-sorbitol biosynthesis I";"Glycolysis";"Gluconeogenesis"
Medex_00036664-RA	4	Reactome: R-HSA-8951664;Reactome: R-HSA-8856825;Reactome: R-HSA-6781823;Reactome: R-HSA-5696394	"Neddylation";"Cargo recognition for clathrin-mediated endocytosis";"Formation of TC-NER Pre-Incision Complex";"DNA Damage Recognition in GG-NER"
Medex_00038250-RA	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
Medex_00009569-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Medex_00032607-RA	7	MetaCyc: PWY-6737;MetaCyc: PWY-5941;KEGG: 00500+2.4.1.25;MetaCyc: PWY-6724;Reactome: R-HSA-6798695;MetaCyc: PWY-7238;Reactome: R-HSA-70221	"Starch degradation V";"Glycogen degradation II";"Starch and sucrose metabolism";"Starch degradation II";"Neutrophil degranulation";"Sucrose biosynthesis II";"Glycogen breakdown (glycogenolysis)"
Medex_00031663-RA	1	Reactome: R-HSA-2022377	"Metabolism of Angiotensinogen to Angiotensins"
Medex_00013424-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00037429-RA	2	Reactome: R-HSA-381340;Reactome: R-HSA-1989781	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression"
Medex_00056134-RA	7	KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1	"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Thermogenesis";"Relaxin signaling pathway";"Human cytomegalovirus infection"
Medex_00049899-RA	3	KEGG: 00531+3.2.1.50;Reactome: R-HSA-2206282;Reactome: R-HSA-2024096	"Glycosaminoglycan degradation";"MPS IIIB - Sanfilippo syndrome B";"HS-GAG degradation"
Medex_00054173-RA	3	Reactome: R-HSA-8963684;KEGG: 00643+1.13.11.5;KEGG: 00350+1.13.11.5	"Tyrosine catabolism";"Styrene degradation";"Tyrosine metabolism"
Medex_00017034-RA	33	Reactome: R-HSA-170822;Reactome: R-HSA-3232142;Reactome: R-HSA-168271;Reactome: R-HSA-191859;Reactome: R-HSA-168325;Reactome: R-HSA-141444;Reactome: R-HSA-4551638;Reactome: R-HSA-159227;Reactome: R-HSA-68877;Reactome: R-HSA-9648025;Reactome: R-HSA-159231;Reactome: R-HSA-168333;Reactome: R-HSA-1169408;Reactome: R-HSA-2467813;Reactome: R-HSA-5663220;Reactome: R-HSA-159230;Reactome: R-HSA-4570464;Reactome: R-HSA-4085377;Reactome: R-HSA-3301854;Reactome: R-HSA-180910;Reactome: R-HSA-159236;Reactome: R-HSA-6784531;Reactome: R-HSA-3108214;Reactome: R-HSA-9609690;Reactome: R-HSA-9610379;Reactome: R-HSA-5619107;Reactome: R-HSA-180746;Reactome: R-HSA-165054;Reactome: R-HSA-5578749;Reactome: R-HSA-2500257;Reactome: R-HSA-168276;Reactome: R-HSA-3371453;Reactome: R-HSA-4615885	"Regulation of Glucokinase by Glucokinase Regulatory Protein";"SUMOylation of ubiquitinylation proteins";"Transport of Ribonucleoproteins into the Host Nucleus";"snRNP Assembly";"Viral Messenger RNA Synthesis";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"SUMOylation of chromatin organization proteins";"Transport of the SLBP independent Mature mRNA";"Mitotic Prometaphase";"EML4 and NUDC in mitotic spindle formation";"Transport of Mature mRNA Derived from an Intronless Transcript";"NEP/NS2 Interacts with the Cellular Export Machinery";"ISG15 antiviral mechanism";"Separation of Sister Chromatids";"RHO GTPases Activate Formins";"Transport of the SLBP Dependant Mature mRNA";"SUMOylation of RNA binding proteins";"SUMOylation of SUMOylation proteins";"Nuclear Pore Complex (NPC) Disassembly";"Vpr-mediated nuclear import of PICs";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"tRNA processing in the nucleus";"SUMOylation of DNA damage response and repair proteins";"HCMV Early Events";"HCMV Late Events";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Nuclear import of Rev protein";"Rev-mediated nuclear export of HIV RNA";"Transcriptional regulation by small RNAs";"Resolution of Sister Chromatid Cohesion";"NS1 Mediated Effects on Host Pathways";"Regulation of HSF1-mediated heat shock response";"SUMOylation of DNA replication proteins"
Medex_00008254-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Medex_00090870-RA	1	Reactome: R-HSA-5601884	"PIWI-interacting RNA (piRNA) biogenesis"
Medex_00039353-RA	5	Reactome: R-HSA-2426168;Reactome: R-HSA-163765;Reactome: R-HSA-9029558;Reactome: R-HSA-75105;Reactome: R-HSA-199220	"Activation of gene expression by SREBF (SREBP)";"ChREBP activates metabolic gene expression";"NR1H2 & NR1H3 regulate gene expression linked to lipogenesis";"Fatty acyl-CoA biosynthesis";"Vitamin B5 (pantothenate) metabolism"
Medex_00067330-RA	1	Reactome: R-HSA-432720	"Lysosome Vesicle Biogenesis"
Medex_00030518-RA	6	Reactome: R-HSA-71240;MetaCyc: PWY-7717;MetaCyc: PWY-5651;KEGG: 00380+1.14.13.9;MetaCyc: PWY-6309;MetaCyc: PWY-7765	"Tryptophan catabolism";"3-hydroxy-4-methyl-anthranilate biosynthesis I";"L-tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde";"Tryptophan metabolism";"L-tryptophan degradation XI (mammalian, via kynurenine)";"3-hydroxy-4-methyl-anthranilate biosynthesis II"
Medex_00086759-RA	2	Reactome: R-HSA-8939243;Reactome: R-HSA-3214858	"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RMTs methylate histone arginines"
Medex_00080226-RA	4	Reactome: R-HSA-2122947;Reactome: R-HSA-2644606;Reactome: R-HSA-2894862;Reactome: R-HSA-350054	"NOTCH1 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Notch-HLH transcription pathway"
Medex_00087218-RA	13	Reactome: R-HSA-975957;Reactome: R-HSA-192823;Reactome: R-HSA-1799339;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-156902;Reactome: R-HSA-9633012;Reactome: R-HSA-975956;Reactome: R-HSA-72706;Reactome: R-HSA-72764;Reactome: R-HSA-72689;Reactome: R-HSA-2408557;Reactome: R-HSA-6791226	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Viral mRNA Translation";"SRP-dependent cotranslational protein targeting to membrane";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Peptide chain elongation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Eukaryotic Translation Termination";"Formation of a pool of free 40S subunits";"Selenocysteine synthesis";"Major pathway of rRNA processing in the nucleolus and cytosol"
Medex_00041662-RA	1	Reactome: R-HSA-6811440	"Retrograde transport at the Trans-Golgi-Network"
Medex_00055165-RA	2	MetaCyc: PWY-7286;Reactome: R-HSA-6782861	"7-(3-amino-3-carboxypropyl)-wyosine biosynthesis";"Synthesis of wybutosine at G37 of tRNA(Phe)"
Medex_00016032-RA	2	Reactome: R-HSA-6796648;Reactome: R-HSA-6783310	"TP53 Regulates Transcription of DNA Repair Genes";"Fanconi Anemia Pathway"
Medex_00012415-RA	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00079027-RA	7	KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1	"Human papillomavirus infection";"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"Human cytomegalovirus infection";"Thermogenesis";"Relaxin signaling pathway"
Medex_00037177-RA	16	Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-156902;Reactome: R-HSA-72695;Reactome: R-HSA-72649;Reactome: R-HSA-192823;Reactome: R-HSA-2408557;Reactome: R-HSA-72689;Reactome: R-HSA-9633012;Reactome: R-HSA-1799339;Reactome: R-HSA-975957;Reactome: R-HSA-6791226;Reactome: R-HSA-72702;Reactome: R-HSA-72764;Reactome: R-HSA-975956;Reactome: R-HSA-72706	"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Peptide chain elongation";"Formation of the ternary complex, and subsequently, the 43S complex";"Translation initiation complex formation";"Viral mRNA Translation";"Selenocysteine synthesis";"Formation of a pool of free 40S subunits";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"Ribosomal scanning and start codon recognition";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit"
Medex_00008596-RA	3	Reactome: R-HSA-983168;Reactome: R-HSA-8951664;Reactome: R-HSA-390471	"Antigen processing: Ubiquitination & Proteasome degradation";"Neddylation";"Association of TriC/CCT with target proteins during biosynthesis"
Medex_00049166-RA	1	Reactome: R-HSA-6809371	"Formation of the cornified envelope"
Medex_00008257-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Medex_00000164-RA	16	Reactome: R-HSA-176412;Reactome: R-HSA-174178;Reactome: R-HSA-174184;Reactome: R-HSA-174154;Reactome: R-HSA-8853884;Reactome: R-HSA-69017;Reactome: R-HSA-176407;Reactome: R-HSA-179409;Reactome: R-HSA-2467813;Reactome: R-HSA-176409;Reactome: R-HSA-174084;Reactome: R-HSA-2559582;Reactome: R-HSA-176408;Reactome: R-HSA-174048;Reactome: R-HSA-983168;Reactome: R-HSA-141430	"Phosphorylation of the APC/C";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"APC/C:Cdc20 mediated degradation of Securin";"Transcriptional Regulation by VENTX";"CDK-mediated phosphorylation and removal of Cdc6";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"APC-Cdc20 mediated degradation of Nek2A";"Separation of Sister Chromatids";"APC/C:Cdc20 mediated degradation of mitotic proteins";"Autodegradation of Cdh1 by Cdh1:APC/C";"Senescence-Associated Secretory Phenotype (SASP)";"Regulation of APC/C activators between G1/S and early anaphase";"APC/C:Cdc20 mediated degradation of Cyclin B";"Antigen processing: Ubiquitination & Proteasome degradation";"Inactivation of APC/C via direct inhibition of the APC/C complex"
Medex_00058681-RA	3	MetaCyc: PWY-5691;KEGG: 00230+1.7.3.3;KEGG: 00232+1.7.3.3	"Urate conversion to allantoin I";"Purine metabolism";"Caffeine metabolism"
Medex_00073784-RA	2	Reactome: R-HSA-3359473;Reactome: R-HSA-196741	"Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD";"Cobalamin (Cbl, vitamin B12) transport and metabolism"
Medex_00042939-RA	5	Reactome: R-HSA-5693579;Reactome: R-HSA-5685942;Reactome: R-HSA-5693568;Reactome: R-HSA-5693554;Reactome: R-HSA-5693616	"Homologous DNA Pairing and Strand Exchange";"HDR through Homologous Recombination (HRR)";"Resolution of D-loop Structures through Holliday Junction Intermediates";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Presynaptic phase of homologous DNA pairing and strand exchange"
Medex_00033270-RA	1	KEGG: 00970+6.1.1.7	"Aminoacyl-tRNA biosynthesis"
Medex_00010015-RA	4	Reactome: R-HSA-1971475;MetaCyc: PWY-6557;KEGG: 00534+2.4.2.26;KEGG: 00532+2.4.2.26	"A tetrasaccharide linker sequence is required for GAG synthesis";"Glycosaminoglycan-protein linkage region biosynthesis";"Glycosaminoglycan biosynthesis - heparan sulfate / heparin";"Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate"
Medex_00003291-RA	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
Medex_00005899-RA	17	MetaCyc: PWY-4202;Reactome: R-HSA-74259;KEGG: 00230+2.4.2.1;Reactome: R-HSA-6798695;MetaCyc: PWY-7179;MetaCyc: PWY-6644;KEGG: 00240+2.4.2.1;MetaCyc: PWY-6608;Reactome: R-HSA-74217;MetaCyc: PWY-5532;MetaCyc: PWY-6611;MetaCyc: PWY-7179-1;KEGG: 00760+2.4.2.1;MetaCyc: PWY-6620;MetaCyc: PWY-6627;MetaCyc: PWY-5695;MetaCyc: PWY-6609	"Arsenate detoxification I (mammalian)";"Purine catabolism";"Purine metabolism";"Neutrophil degranulation";"Purine deoxyribonucleosides degradation I";"Fluoroacetate and fluorothreonine biosynthesis";"Pyrimidine metabolism";"Guanosine nucleotides degradation III";"Purine salvage";"Nucleoside and nucleotide degradation (archaea)";"Adenine and adenosine salvage V";"Purine deoxyribonucleosides degradation II";"Nicotinate and nicotinamide metabolism";"Guanine and guanosine salvage";"Salinosporamide A biosynthesis";"Inosine 5'-phosphate degradation";"Adenine and adenosine salvage III"
Medex_00006636-RA	1	KEGG: 00480+3.4.11.2	"Glutathione metabolism"
Medex_00080013-RA	2	Reactome: R-HSA-446203;Reactome: R-HSA-1799339	"Asparagine N-linked glycosylation";"SRP-dependent cotranslational protein targeting to membrane"
Medex_00023791-RA	1	Reactome: R-HSA-9633012	"Response of EIF2AK4 (GCN2) to amino acid deficiency"
Medex_00090024-RA	1	Reactome: R-HSA-611105	"Respiratory electron transport"
Medex_00088764-RA	3	Reactome: R-HSA-72165;Reactome: R-HSA-191859;Reactome: R-HSA-72163	"mRNA Splicing - Minor Pathway";"snRNP Assembly";"mRNA Splicing - Major Pathway"
Medex_00002096-RA	1	Reactome: R-HSA-1799339	"SRP-dependent cotranslational protein targeting to membrane"
Medex_00017939-RA	1	Reactome: R-HSA-5620922	"BBSome-mediated cargo-targeting to cilium"
Medex_00031601-RA	1	Reactome: R-HSA-389957	"Prefoldin mediated transfer of substrate to CCT/TriC"
Medex_00092255-RA	6	Reactome: R-HSA-3000171;Reactome: R-HSA-2022090;Reactome: R-HSA-8948216;Reactome: R-HSA-8874081;Reactome: R-HSA-1442490;Reactome: R-HSA-1650814	"Non-integrin membrane-ECM interactions";"Assembly of collagen fibrils and other multimeric structures";"Collagen chain trimerization";"MET activates PTK2 signaling";"Collagen degradation";"Collagen biosynthesis and modifying enzymes"
Medex_00010718-RA	1	Reactome: R-HSA-2132295	"MHC class II antigen presentation"
Medex_00083314-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00023350-RA	8	Reactome: R-HSA-5620912;Reactome: R-HSA-8854518;Reactome: R-HSA-380320;Reactome: R-HSA-6798695;Reactome: R-HSA-2565942;Reactome: R-HSA-380284;Reactome: R-HSA-380270;Reactome: R-HSA-380259	"Anchoring of the basal body to the plasma membrane";"AURKA Activation by TPX2";"Recruitment of NuMA to mitotic centrosomes";"Neutrophil degranulation";"Regulation of PLK1 Activity at G2/M Transition";"Loss of proteins required for interphase microtubule organization from the centrosome";"Recruitment of mitotic centrosome proteins and complexes";"Loss of Nlp from mitotic centrosomes"
Medex_00074941-RA	2	Reactome: R-HSA-532668;Reactome: R-HSA-6798695	"N-glycan trimming in the ER and Calnexin/Calreticulin cycle";"Neutrophil degranulation"
Medex_00027880-RA	1	Reactome: R-HSA-420029	"Tight junction interactions"
Medex_00062437-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Medex_00006942-RA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Medex_00094204-RA	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
Medex_00034590-RA	1	Reactome: R-HSA-6809371	"Formation of the cornified envelope"
Medex_00062378-RA	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
Medex_00032854-RA	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
Medex_00058137-RA	1	Reactome: R-HSA-3000178	"ECM proteoglycans"
Medex_00048380-RA	2	Reactome: R-HSA-9603798;Reactome: R-HSA-1369062	"Class I peroxisomal membrane protein import";"ABC transporters in lipid homeostasis"
Medex_00060885-RA	2	Reactome: R-HSA-181429;Reactome: R-HSA-212676	"Serotonin Neurotransmitter Release Cycle";"Dopamine Neurotransmitter Release Cycle"
Medex_00091855-RA	16	Reactome: R-HSA-975956;Reactome: R-HSA-72706;Reactome: R-HSA-72764;Reactome: R-HSA-72702;Reactome: R-HSA-6791226;Reactome: R-HSA-975957;Reactome: R-HSA-1799339;Reactome: R-HSA-9633012;Reactome: R-HSA-72689;Reactome: R-HSA-2408557;Reactome: R-HSA-192823;Reactome: R-HSA-72649;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-72695;Reactome: R-HSA-156902	"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Eukaryotic Translation Termination";"Ribosomal scanning and start codon recognition";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Formation of a pool of free 40S subunits";"Selenocysteine synthesis";"Viral mRNA Translation";"Translation initiation complex formation";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Formation of the ternary complex, and subsequently, the 43S complex";"Peptide chain elongation"
Medex_00060144-RA	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
Medex_00018420-RA	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
Medex_00031632-RA	1	Reactome: R-HSA-1445148	"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
Medex_00035546-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00049380-RA	4	Reactome: R-HSA-5693568;Reactome: R-HSA-5693554;Reactome: R-HSA-5693579;Reactome: R-HSA-5685942	"Resolution of D-loop Structures through Holliday Junction Intermediates";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Homologous DNA Pairing and Strand Exchange";"HDR through Homologous Recombination (HRR)"
Medex_00075092-RA	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
Medex_00020473-RA	8	MetaCyc: PWY-7921;KEGG: 00515+2.4.1.109;Reactome: R-HSA-5083629;Reactome: R-HSA-5173105;MetaCyc: PWY-7922;Reactome: R-HSA-5083633;MetaCyc: PWY-7979;KEGG: 00514+2.4.1.109	"Protein O-mannosylation I (yeast)";"Mannose type O-glycan biosynthesis";"Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2";"O-linked glycosylation";"Protein O-mannosylation II (mammals, core M1 and core M2)";"Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1";"Protein O-mannosylation III (mammals, core M3)";"Other types of O-glycan biosynthesis"
Medex_00065386-RA	10	Reactome: R-HSA-3899300;Reactome: R-HSA-8936459;Reactome: R-HSA-427413;Reactome: R-HSA-9022538;Reactome: R-HSA-400206;Reactome: R-HSA-9022692;Reactome: R-HSA-9022699;Reactome: R-HSA-983231;Reactome: R-HSA-9615017;Reactome: R-HSA-9022702	"SUMOylation of transcription cofactors";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"NoRC negatively regulates rRNA expression";"Loss of MECP2 binding ability to 5mC-DNA";"Regulation of lipid metabolism by PPARalpha";"Regulation of MECP2 expression and activity";"MECP2 regulates neuronal receptors and channels";"Factors involved in megakaryocyte development and platelet production";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"MECP2 regulates transcription of neuronal ligands"
Medex_00070823-RA	5	Reactome: R-HSA-9610379;Reactome: R-HSA-9615710;Reactome: R-HSA-917729;Reactome: R-HSA-174490;Reactome: R-HSA-162588	"HCMV Late Events";"Late endosomal microautophagy";"Endosomal Sorting Complex Required For Transport (ESCRT)";"Membrane binding and targetting of GAG proteins";"Budding and maturation of HIV virion"
Medex_00007179-RA	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
Medex_00073122-RA	2	Reactome: R-HSA-3214847;Reactome: R-HSA-171319	"HATs acetylate histones";"Telomere Extension By Telomerase"
Medex_00080243-RA	3	Reactome: R-HSA-2142691;Reactome: R-HSA-5423646;MetaCyc: PWY-7533	"Synthesis of Leukotrienes (LT) and Eoxins (EX)";"Aflatoxin activation and detoxification";"Gliotoxin biosynthesis"
Medex_00066392-RA	1	Reactome: R-HSA-8953750	"Transcriptional Regulation by E2F6"
Medex_00044151-RA	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
Medex_00021337-RA	6	KEGG: 00600+3.2.1.23;KEGG: 00511+3.2.1.23;MetaCyc: PWY-6807;KEGG: 00604+3.2.1.23;KEGG: 00052+3.2.1.23;KEGG: 00531+3.2.1.23	"Sphingolipid metabolism";"Other glycan degradation";"Xyloglucan degradation II (exoglucanase)";"Glycosphingolipid biosynthesis - ganglio series";"Galactose metabolism";"Glycosaminoglycan degradation"
Medex_00037577-RA	26	Reactome: R-HSA-1368082;Reactome: R-HSA-9018519;Reactome: R-HSA-3371568;Reactome: R-HSA-918233;Reactome: R-HSA-5617472;Reactome: R-HSA-5621575;Reactome: R-HSA-933541;Reactome: R-HSA-2894862;Reactome: R-HSA-3899300;Reactome: R-HSA-9013695;Reactome: R-HSA-2122947;Reactome: R-HSA-381340;Reactome: R-HSA-1234158;Reactome: R-HSA-9614657;Reactome: R-HSA-8866907;Reactome: R-HSA-210744;Reactome: R-HSA-1912408;Reactome: R-HSA-1989781;Reactome: R-HSA-400253;Reactome: R-HSA-9013508;Reactome: R-HSA-3214847;Reactome: R-HSA-201722;Reactome: R-HSA-2644606;Reactome: R-HSA-9617629;Reactome: R-HSA-3134973;Reactome: R-HSA-8941856	"RORA activates gene expression";"Estrogen-dependent gene expression";"Attenuation phase";"TRAF3-dependent IRF activation pathway";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"CD209 (DC-SIGN) signaling";"TRAF6 mediated IRF7 activation";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"SUMOylation of transcription cofactors";"NOTCH4 Intracellular Domain Regulates Transcription";"NOTCH1 Intracellular Domain Regulates Transcription";"Transcriptional regulation of white adipocyte differentiation";"Regulation of gene expression by Hypoxia-inducible Factor";"FOXO-mediated transcription of cell death genes";"Activation of the TFAP2 (AP-2) family of transcription factors";"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"Pre-NOTCH Transcription and Translation";"PPARA activates gene expression";"Circadian Clock";"NOTCH3 Intracellular Domain Regulates Transcription";"HATs acetylate histones";"Formation of the beta-catenin:TCF transactivating complex";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Regulation of FOXO transcriptional activity by acetylation";"LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production";"RUNX3 regulates NOTCH signaling"
Medex_00004110-RA	3	Reactome: R-HSA-4420097;Reactome: R-HSA-2029482;Reactome: R-HSA-5663213	"VEGFA-VEGFR2 Pathway";"Regulation of actin dynamics for phagocytic cup formation";"RHO GTPases Activate WASPs and WAVEs"
Medex_00085000-RA	5	KEGG: 00720+4.2.1.3;KEGG: 00290+4.2.1.33;Reactome: R-HSA-917937;KEGG: 00020+4.2.1.3;KEGG: 00630+4.2.1.3	"Carbon fixation pathways in prokaryotes";"Valine, leucine and isoleucine biosynthesis";"Iron uptake and transport";"Citrate cycle (TCA cycle)";"Glyoxylate and dicarboxylate metabolism"
Medex_00036863-RA	33	Reactome: R-HSA-180746;Reactome: R-HSA-165054;Reactome: R-HSA-2500257;Reactome: R-HSA-168276;Reactome: R-HSA-5578749;Reactome: R-HSA-3371453;Reactome: R-HSA-4615885;Reactome: R-HSA-4570464;Reactome: R-HSA-4085377;Reactome: R-HSA-3301854;Reactome: R-HSA-180910;Reactome: R-HSA-159236;Reactome: R-HSA-3108214;Reactome: R-HSA-6784531;Reactome: R-HSA-9609690;Reactome: R-HSA-9610379;Reactome: R-HSA-5619107;Reactome: R-HSA-159227;Reactome: R-HSA-9648025;Reactome: R-HSA-159231;Reactome: R-HSA-68877;Reactome: R-HSA-1169408;Reactome: R-HSA-2467813;Reactome: R-HSA-168333;Reactome: R-HSA-159230;Reactome: R-HSA-5663220;Reactome: R-HSA-170822;Reactome: R-HSA-3232142;Reactome: R-HSA-168271;Reactome: R-HSA-168325;Reactome: R-HSA-191859;Reactome: R-HSA-141444;Reactome: R-HSA-4551638	"Nuclear import of Rev protein";"Rev-mediated nuclear export of HIV RNA";"Resolution of Sister Chromatid Cohesion";"NS1 Mediated Effects on Host Pathways";"Transcriptional regulation by small RNAs";"Regulation of HSF1-mediated heat shock response";"SUMOylation of DNA replication proteins";"SUMOylation of RNA binding proteins";"SUMOylation of SUMOylation proteins";"Nuclear Pore Complex (NPC) Disassembly";"Vpr-mediated nuclear import of PICs";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"SUMOylation of DNA damage response and repair proteins";"tRNA processing in the nucleus";"HCMV Early Events";"HCMV Late Events";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Transport of the SLBP independent Mature mRNA";"EML4 and NUDC in mitotic spindle formation";"Transport of Mature mRNA Derived from an Intronless Transcript";"Mitotic Prometaphase";"ISG15 antiviral mechanism";"Separation of Sister Chromatids";"NEP/NS2 Interacts with the Cellular Export Machinery";"Transport of the SLBP Dependant Mature mRNA";"RHO GTPases Activate Formins";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"SUMOylation of ubiquitinylation proteins";"Transport of Ribonucleoproteins into the Host Nucleus";"Viral Messenger RNA Synthesis";"snRNP Assembly";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"SUMOylation of chromatin organization proteins"
Medex_00005873-RA	1	Reactome: R-HSA-426117	"Cation-coupled Chloride cotransporters"
Medex_00029867-RA	3	KEGG: 00270+1.13.11.54;Reactome: R-HSA-1237112;MetaCyc: PWY-4361	"Cysteine and methionine metabolism";"Methionine salvage pathway";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I"
Medex_00083420-RA	24	Reactome: R-HSA-8955332;Reactome: R-HSA-6811436;Reactome: R-HSA-9609690;Reactome: R-HSA-6807878;Reactome: R-HSA-437239;Reactome: R-HSA-190840;Reactome: R-HSA-190861;Reactome: R-HSA-9619483;Reactome: R-HSA-2132295;Reactome: R-HSA-5626467;Reactome: R-HSA-9609736;Reactome: R-HSA-983189;Reactome: R-HSA-8852276;Reactome: R-HSA-1445148;Reactome: R-HSA-5663220;Reactome: R-HSA-3371497;Reactome: R-HSA-380320;Reactome: R-HSA-2500257;Reactome: R-HSA-5617833;Reactome: R-HSA-9646399;Reactome: R-HSA-2467813;Reactome: R-HSA-9648025;Reactome: R-HSA-6811434;Reactome: R-HSA-68877	"Carboxyterminal post-translational modifications of tubulin";"COPI-independent Golgi-to-ER retrograde traffic";"HCMV Early Events";"COPI-mediated anterograde transport";"Recycling pathway of L1";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Gap junction assembly";"Activation of AMPK downstream of NMDARs";"MHC class II antigen presentation";"RHO GTPases activate IQGAPs";"Assembly and cell surface presentation of NMDA receptors";"Kinesins";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"RHO GTPases Activate Formins";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Recruitment of NuMA to mitotic centrosomes";"Resolution of Sister Chromatid Cohesion";"Cilium Assembly";"Aggrephagy";"Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation";"COPI-dependent Golgi-to-ER retrograde traffic";"Mitotic Prometaphase"
Medex_00016153-RA	2	Reactome: R-HSA-4090294;Reactome: R-HSA-383280	"SUMOylation of intracellular receptors";"Nuclear Receptor transcription pathway"
Medex_00003007-RA	10	Reactome: R-HSA-76042;Reactome: R-HSA-9018519;Reactome: R-HSA-167162;Reactome: R-HSA-73779;Reactome: R-HSA-167172;Reactome: R-HSA-75953;Reactome: R-HSA-167161;Reactome: R-HSA-73776;Reactome: R-HSA-6807505;Reactome: R-HSA-674695	"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Estrogen-dependent gene expression";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Transcription of the HIV genome";"RNA Polymerase II Transcription Initiation";"HIV Transcription Initiation";"RNA Polymerase II Promoter Escape";"RNA polymerase II transcribes snRNA genes";"RNA Polymerase II Pre-transcription Events"
Medex_00034634-RA	1	Reactome: R-HSA-5663220	"RHO GTPases Activate Formins"
Medex_00092707-RA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
Medex_00017975-RA	2	Reactome: R-HSA-390471;Reactome: R-HSA-1660662	"Association of TriC/CCT with target proteins during biosynthesis";"Glycosphingolipid metabolism"
Medex_00047358-RA	14	MetaCyc: PWY-6433;MetaCyc: PWY-7619;MetaCyc: PWY-7602;MetaCyc: PWY-7036;Reactome: R-HSA-75876;MetaCyc: PWY-7035;MetaCyc: PWY-5972;MetaCyc: PWY-7724;MetaCyc: PWY-7601;MetaCyc: PWY-7725;KEGG: 00062+2.3.1.199;MetaCyc: PWY-6598;MetaCyc: PWY-5080;MetaCyc: PWY-8041	"Hydroxylated fatty acid biosynthesis (plants)";"Juniperonate biosynthesis";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis II";"Synthesis of very long-chain fatty acyl-CoAs";"(9Z)-tricosene biosynthesis";"Stearate biosynthesis I (animals)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Fatty acid elongation";"Sciadonate biosynthesis";"Very long chain fatty acid biosynthesis I";"Ultra-long-chain fatty acid biosynthesis"
Medex_00055443-RA	5	MetaCyc: PWY-5514;Reactome: R-HSA-70171;MetaCyc: PWY-6906;KEGG: 00520+3.5.99.6;MetaCyc: PWY-6855	"UDP-N-acetyl-D-galactosamine biosynthesis II";"Glycolysis";"Chitin derivatives degradation";"Amino sugar and nucleotide sugar metabolism";"Chitin degradation I (archaea)"
Medex_00088021-RA	1	Reactome: R-HSA-6798163	"Choline catabolism"
Medex_00051863-RA	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
Medex_00092176-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Medex_00060394-RA	2	Reactome: R-HSA-375280;Reactome: R-HSA-416476	"Amine ligand-binding receptors";"G alpha (q) signalling events"
Medex_00088487-RA	2	Reactome: R-HSA-6783310;Reactome: R-HSA-606279	"Fanconi Anemia Pathway";"Deposition of new CENPA-containing nucleosomes at the centromere"
Medex_00064341-RA	5	Reactome: R-HSA-75109;Reactome: R-HSA-1482883;KEGG: 00073+2.3.1.20;Reactome: R-HSA-6798695;KEGG: 00561+2.3.1.20	"Triglyceride biosynthesis";"Acyl chain remodeling of DAG and TAG";"Cutin, suberine and wax biosynthesis";"Neutrophil degranulation";"Glycerolipid metabolism"
Medex_00017080-RA	6	MetaCyc: PWY-2221;KEGG: 00030+3.1.1.17;MetaCyc: PWY-5530;KEGG: 00930+3.1.1.17;MetaCyc: PWY-7165;KEGG: 00053+3.1.1.17	"Entner-Doudoroff pathway III (semi-phosphorylative)";"Pentose phosphate pathway";"Sorbitol biosynthesis II";"Caprolactam degradation";"L-ascorbate biosynthesis VI (engineered pathway)";"Ascorbate and aldarate metabolism"
Medex_00015530-RA	6	KEGG: 00052+3.2.1.23;KEGG: 00531+3.2.1.23;MetaCyc: PWY-6807;KEGG: 00511+3.2.1.23;KEGG: 00600+3.2.1.23;KEGG: 00604+3.2.1.23	"Galactose metabolism";"Glycosaminoglycan degradation";"Xyloglucan degradation II (exoglucanase)";"Other glycan degradation";"Sphingolipid metabolism";"Glycosphingolipid biosynthesis - ganglio series"
Medex_00038221-RA	26	Reactome: R-HSA-1912408;Reactome: R-HSA-1989781;Reactome: R-HSA-400253;Reactome: R-HSA-9013508;Reactome: R-HSA-201722;Reactome: R-HSA-3214847;Reactome: R-HSA-2644606;Reactome: R-HSA-9617629;Reactome: R-HSA-3134973;Reactome: R-HSA-8941856;Reactome: R-HSA-1368082;Reactome: R-HSA-9018519;Reactome: R-HSA-918233;Reactome: R-HSA-3371568;Reactome: R-HSA-5617472;Reactome: R-HSA-5621575;Reactome: R-HSA-933541;Reactome: R-HSA-2894862;Reactome: R-HSA-3899300;Reactome: R-HSA-2122947;Reactome: R-HSA-381340;Reactome: R-HSA-9013695;Reactome: R-HSA-8866907;Reactome: R-HSA-9614657;Reactome: R-HSA-1234158;Reactome: R-HSA-210744	"Pre-NOTCH Transcription and Translation";"PPARA activates gene expression";"Circadian Clock";"NOTCH3 Intracellular Domain Regulates Transcription";"Formation of the beta-catenin:TCF transactivating complex";"HATs acetylate histones";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Regulation of FOXO transcriptional activity by acetylation";"LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production";"RUNX3 regulates NOTCH signaling";"RORA activates gene expression";"Estrogen-dependent gene expression";"TRAF3-dependent IRF activation pathway";"Attenuation phase";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"CD209 (DC-SIGN) signaling";"TRAF6 mediated IRF7 activation";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"SUMOylation of transcription cofactors";"NOTCH1 Intracellular Domain Regulates Transcription";"Transcriptional regulation of white adipocyte differentiation";"NOTCH4 Intracellular Domain Regulates Transcription";"Activation of the TFAP2 (AP-2) family of transcription factors";"FOXO-mediated transcription of cell death genes";"Regulation of gene expression by Hypoxia-inducible Factor";"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells"
Medex_00050011-RA	11	Reactome: R-HSA-8964539;MetaCyc: PWY-381;KEGG: 00630+6.3.1.2;KEGG: 00910+6.3.1.2;MetaCyc: PWY-6964;MetaCyc: PWY-6549;Reactome: R-HSA-210455;KEGG: 00250+6.3.1.2;MetaCyc: PWY-5675;KEGG: 00220+6.3.1.2;MetaCyc: PWY-6963	"Glutamate and glutamine metabolism";"Nitrate reduction II (assimilatory)";"Glyoxylate and dicarboxylate metabolism";"Nitrogen metabolism";"Ammonia assimilation cycle II";"L-glutamine biosynthesis III";"Astrocytic Glutamate-Glutamine Uptake And Metabolism";"Alanine, aspartate and glutamate metabolism";"Nitrate reduction V (assimilatory)";"Arginine biosynthesis";"Ammonia assimilation cycle I"
Medex_00039504-RA	3	Reactome: R-HSA-5689880;Reactome: R-HSA-201722;Reactome: R-HSA-3214847	"Ub-specific processing proteases";"Formation of the beta-catenin:TCF transactivating complex";"HATs acetylate histones"
Medex_00055086-RA	13	Reactome: R-HSA-2022090;Reactome: R-HSA-8948216;Reactome: R-HSA-1442490;Reactome: R-HSA-216083;Reactome: R-HSA-2243919;Reactome: R-HSA-1650814;Reactome: R-HSA-3000171;Reactome: R-HSA-186797;Reactome: R-HSA-3000178;Reactome: R-HSA-3000157;Reactome: R-HSA-419037;Reactome: R-HSA-1474244;Reactome: R-HSA-2214320	"Assembly of collagen fibrils and other multimeric structures";"Collagen chain trimerization";"Collagen degradation";"Integrin cell surface interactions";"Crosslinking of collagen fibrils";"Collagen biosynthesis and modifying enzymes";"Non-integrin membrane-ECM interactions";"Signaling by PDGF";"ECM proteoglycans";"Laminin interactions";"NCAM1 interactions";"Extracellular matrix organization";"Anchoring fibril formation"
Medex_00010220-RA	2	Reactome: R-HSA-8936459;Reactome: R-HSA-3214841	"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"PKMTs methylate histone lysines"
Medex_00090472-RA	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5419276;Reactome: R-HSA-5389840	"Mitochondrial translation initiation";"Mitochondrial translation termination";"Mitochondrial translation elongation"
Medex_00003901-RA	56	Reactome: R-HSA-5632684;Reactome: R-HSA-180534;Reactome: R-HSA-349425;Reactome: R-HSA-1236978;Reactome: R-HSA-8852276;Reactome: R-HSA-5610780;Reactome: R-HSA-5607761;Reactome: R-HSA-174178;Reactome: R-HSA-75815;Reactome: R-HSA-8939902;Reactome: R-HSA-195253;Reactome: R-HSA-5689880;Reactome: R-HSA-5610785;Reactome: R-HSA-4608870;Reactome: R-HSA-5689603;Reactome: R-HSA-5668541;Reactome: R-HSA-5687128;Reactome: R-HSA-2467813;Reactome: R-HSA-4641258;Reactome: R-HSA-450408;Reactome: R-HSA-180585;Reactome: R-HSA-382556;Reactome: R-HSA-68949;Reactome: R-HSA-8939236;Reactome: R-HSA-211733;Reactome: R-HSA-9010553;Reactome: R-HSA-5358346;Reactome: R-HSA-8941858;Reactome: R-HSA-5658442;Reactome: R-HSA-202424;Reactome: R-HSA-983168;Reactome: R-HSA-9020702;Reactome: R-HSA-174154;Reactome: R-HSA-1169091;Reactome: R-HSA-174184;Reactome: R-HSA-5607764;Reactome: R-HSA-2871837;Reactome: R-HSA-8951664;Reactome: R-HSA-69481;Reactome: R-HSA-5678895;Reactome: R-HSA-350562;Reactome: R-HSA-4641257;Reactome: R-HSA-174113;Reactome: R-HSA-5676590;Reactome: R-HSA-5362768;Reactome: R-HSA-1234176;Reactome: R-HSA-69017;Reactome: R-HSA-69601;Reactome: R-HSA-9604323;Reactome: R-HSA-8948751;Reactome: R-HSA-68827;Reactome: R-HSA-5610783;Reactome: R-HSA-8854050;Reactome: R-HSA-1236974;Reactome: R-HSA-174084;Reactome: R-HSA-187577	"Hedgehog 'on' state";"Vpu mediated degradation of CD4";"Autodegradation of the E3 ubiquitin ligase COP1";"Cross-presentation of soluble exogenous antigens (endosomes)";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Degradation of GLI1 by the proteasome";"Dectin-1 mediated noncanonical NF-kB signaling";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Ubiquitin-dependent degradation of Cyclin D";"Regulation of RUNX2 expression and activity";"Degradation of beta-catenin by the destruction complex";"Ub-specific processing proteases";"GLI3 is processed to GLI3R by the proteasome";"Asymmetric localization of PCP proteins";"UCH proteinases";"TNFR2 non-canonical NF-kB pathway";"MAPK6/MAPK4 signaling";"Separation of Sister Chromatids";"Degradation of DVL";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Vif-mediated degradation of APOBEC3G";"ABC-family proteins mediated transport";"Orc1 removal from chromatin";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Regulation of expression of SLITs and ROBOs";"Hedgehog ligand biogenesis";"Regulation of RUNX3 expression and activity";"Regulation of RAS by GAPs";"Downstream TCR signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Interleukin-1 signaling";"APC/C:Cdc20 mediated degradation of Securin";"Activation of NF-kappaB in B cells";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"CLEC7A (Dectin-1) signaling";"FCERI mediated NF-kB activation";"Neddylation";"G2/M Checkpoints";"Defective CFTR causes cystic fibrosis";"Regulation of ornithine decarboxylase (ODC)";"Degradation of AXIN";"SCF-beta-TrCP mediated degradation of Emi1";"NIK-->noncanonical NF-kB signaling";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"CDK-mediated phosphorylation and removal of Cdc6";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Negative regulation of NOTCH4 signaling";"Regulation of PTEN stability and activity";"CDT1 association with the CDC6:ORC:origin complex";"Degradation of GLI2 by the proteasome";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"ER-Phagosome pathway";"Autodegradation of Cdh1 by Cdh1:APC/C";"SCF(Skp2)-mediated degradation of p27/p21"
Medex_00018890-RA	3	Reactome: R-HSA-1989781;Reactome: R-HSA-381340;Reactome: R-HSA-212436	"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation";"Generic Transcription Pathway"
Medex_00071029-RA	6	Reactome: R-HSA-6798695;Reactome: R-HSA-2453864;Reactome: R-HSA-975634;Reactome: R-HSA-3000171;Reactome: R-HSA-2453902;Reactome: R-HSA-977225	"Neutrophil degranulation";"Retinoid cycle disease events";"Retinoid metabolism and transport";"Non-integrin membrane-ECM interactions";"The canonical retinoid cycle in rods (twilight vision)";"Amyloid fiber formation"
Medex_00058995-RA	3	KEGG: 00730+3.1.3.2;KEGG: 00740+3.1.3.2;MetaCyc: PWY-6348	"Thiamine metabolism";"Riboflavin metabolism";"Phosphate acquisition"
Medex_00022231-RA	1	Reactome: R-HSA-1660661	"Sphingolipid de novo biosynthesis"
Medex_00091218-RA	6	KEGG: 00260+5.4.2.11;MetaCyc: PWY-8004;MetaCyc: PWY-1622;MetaCyc: PWY-5484;KEGG: 00680+5.4.2.11;KEGG: 00010+5.4.2.11	"Glycine, serine and threonine metabolism";"Entner-Doudoroff pathway I";"Formaldehyde assimilation I (serine pathway)";"Glycolysis II (from fructose 6-phosphate)";"Methane metabolism";"Glycolysis / Gluconeogenesis"
Medex_00001712-RA	1	KEGG: 00970+6.3.5.7	"Aminoacyl-tRNA biosynthesis"
Medex_00035641-RA	1	Reactome: R-HSA-432047	"Passive transport by Aquaporins"
Medex_00086045-RA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
Medex_00093030-RA	2	Reactome: R-HSA-380270;Reactome: R-HSA-380320	"Recruitment of mitotic centrosome proteins and complexes";"Recruitment of NuMA to mitotic centrosomes"
Medex_00004947-RA	1	Reactome: R-HSA-211981	"Xenobiotics"
Medex_00055344-RA	3	Reactome: R-HSA-73856;Reactome: R-HSA-72187;Reactome: R-HSA-159236	"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing";"Transport of Mature mRNA derived from an Intron-Containing Transcript"
Medex_00000078-RA	1	KEGG: 00480+3.4.11.2	"Glutathione metabolism"
Medex_00015892-RA	1	Reactome: R-HSA-2132295	"MHC class II antigen presentation"
Medex_00044629-RA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
Medex_00032919-RA	56	Reactome: R-HSA-187577;Reactome: R-HSA-174084;Reactome: R-HSA-5610783;Reactome: R-HSA-1236974;Reactome: R-HSA-8854050;Reactome: R-HSA-5678895;Reactome: R-HSA-350562;Reactome: R-HSA-69481;Reactome: R-HSA-174113;Reactome: R-HSA-4641257;Reactome: R-HSA-69017;Reactome: R-HSA-1234176;Reactome: R-HSA-5362768;Reactome: R-HSA-69601;Reactome: R-HSA-5676590;Reactome: R-HSA-68827;Reactome: R-HSA-9604323;Reactome: R-HSA-8948751;Reactome: R-HSA-1169091;Reactome: R-HSA-174154;Reactome: R-HSA-5607764;Reactome: R-HSA-174184;Reactome: R-HSA-8951664;Reactome: R-HSA-2871837;Reactome: R-HSA-5658442;Reactome: R-HSA-8941858;Reactome: R-HSA-5358346;Reactome: R-HSA-983168;Reactome: R-HSA-202424;Reactome: R-HSA-9020702;Reactome: R-HSA-4641258;Reactome: R-HSA-2467813;Reactome: R-HSA-180585;Reactome: R-HSA-450408;Reactome: R-HSA-9010553;Reactome: R-HSA-211733;Reactome: R-HSA-8939236;Reactome: R-HSA-382556;Reactome: R-HSA-68949;Reactome: R-HSA-8939902;Reactome: R-HSA-75815;Reactome: R-HSA-195253;Reactome: R-HSA-5610785;Reactome: R-HSA-5689880;Reactome: R-HSA-5668541;Reactome: R-HSA-5687128;Reactome: R-HSA-5689603;Reactome: R-HSA-4608870;Reactome: R-HSA-5632684;Reactome: R-HSA-1236978;Reactome: R-HSA-349425;Reactome: R-HSA-180534;Reactome: R-HSA-5607761;Reactome: R-HSA-5610780;Reactome: R-HSA-8852276;Reactome: R-HSA-174178	"SCF(Skp2)-mediated degradation of p27/p21";"Autodegradation of Cdh1 by Cdh1:APC/C";"Degradation of GLI2 by the proteasome";"ER-Phagosome pathway";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Defective CFTR causes cystic fibrosis";"Regulation of ornithine decarboxylase (ODC)";"G2/M Checkpoints";"SCF-beta-TrCP mediated degradation of Emi1";"Degradation of AXIN";"CDK-mediated phosphorylation and removal of Cdc6";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"NIK-->noncanonical NF-kB signaling";"CDT1 association with the CDC6:ORC:origin complex";"Negative regulation of NOTCH4 signaling";"Regulation of PTEN stability and activity";"Activation of NF-kappaB in B cells";"APC/C:Cdc20 mediated degradation of Securin";"CLEC7A (Dectin-1) signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Neddylation";"FCERI mediated NF-kB activation";"Regulation of RAS by GAPs";"Regulation of RUNX3 expression and activity";"Hedgehog ligand biogenesis";"Antigen processing: Ubiquitination & Proteasome degradation";"Downstream TCR signaling";"Interleukin-1 signaling";"Degradation of DVL";"Separation of Sister Chromatids";"Vif-mediated degradation of APOBEC3G";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Regulation of expression of SLITs and ROBOs";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"ABC-family proteins mediated transport";"Orc1 removal from chromatin";"Regulation of RUNX2 expression and activity";"Ubiquitin-dependent degradation of Cyclin D";"Degradation of beta-catenin by the destruction complex";"GLI3 is processed to GLI3R by the proteasome";"Ub-specific processing proteases";"TNFR2 non-canonical NF-kB pathway";"MAPK6/MAPK4 signaling";"UCH proteinases";"Asymmetric localization of PCP proteins";"Hedgehog 'on' state";"Cross-presentation of soluble exogenous antigens (endosomes)";"Autodegradation of the E3 ubiquitin ligase COP1";"Vpu mediated degradation of CD4";"Dectin-1 mediated noncanonical NF-kB signaling";"Degradation of GLI1 by the proteasome";"The role of GTSE1 in G2/M progression after G2 checkpoint";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1"
Medex_00028123-RA	1	Reactome: R-HSA-6785631	"ERBB2 Regulates Cell Motility"
Medex_00091880-RA	1	Reactome: R-HSA-6809371	"Formation of the cornified envelope"
Medex_00023520-RA	3	Reactome: R-HSA-6807878;Reactome: R-HSA-6811434;Reactome: R-HSA-6798695	"COPI-mediated anterograde transport";"COPI-dependent Golgi-to-ER retrograde traffic";"Neutrophil degranulation"
Medex_00023480-RA	1	Reactome: R-HSA-211981	"Xenobiotics"
Medex_00076175-RA	2	Reactome: R-HSA-8856828;Reactome: R-HSA-5627123	"Clathrin-mediated endocytosis";"RHO GTPases activate PAKs"
Medex_00081982-RA	12	Reactome: R-HSA-9646399;Reactome: R-HSA-2467813;Reactome: R-HSA-9648025;Reactome: R-HSA-68877;Reactome: R-HSA-6811436;Reactome: R-HSA-9609690;Reactome: R-HSA-6807878;Reactome: R-HSA-5663220;Reactome: R-HSA-2132295;Reactome: R-HSA-3371497;Reactome: R-HSA-2500257;Reactome: R-HSA-141444	"Aggrephagy";"Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation";"Mitotic Prometaphase";"COPI-independent Golgi-to-ER retrograde traffic";"HCMV Early Events";"COPI-mediated anterograde transport";"RHO GTPases Activate Formins";"MHC class II antigen presentation";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"
Medex_00004386-RA	6	KEGG: 00604+3.2.1.23;MetaCyc: PWY-6807;KEGG: 00600+3.2.1.23;KEGG: 00511+3.2.1.23;KEGG: 00531+3.2.1.23;KEGG: 00052+3.2.1.23	"Glycosphingolipid biosynthesis - ganglio series";"Xyloglucan degradation II (exoglucanase)";"Sphingolipid metabolism";"Other glycan degradation";"Glycosaminoglycan degradation";"Galactose metabolism"
Medex_00056178-RA	5	MetaCyc: PWY-7790;MetaCyc: PWY-7791;MetaCyc: PWY-5686;KEGG: 00240+4.1.1.23;Reactome: R-HSA-500753	"UMP biosynthesis II";"UMP biosynthesis III";"UMP biosynthesis I";"Pyrimidine metabolism";"Pyrimidine biosynthesis"
Medex_00050361-RA	1	Reactome: R-HSA-69273	"Cyclin A/B1/B2 associated events during G2/M transition"
Medex_00001129-RA	1	Reactome: R-HSA-2132295	"MHC class II antigen presentation"
Medex_00009930-RA	5	Reactome: R-HSA-6798695;KEGG: 00750+2.7.1.35;Reactome: R-HSA-964975;MetaCyc: PWY-7282;MetaCyc: PWY-7204	"Neutrophil degranulation";"Vitamin B6 metabolism";"Vitamins B6 activation to pyridoxal phosphate";"4-amino-2-methyl-5-phosphomethylpyrimidine biosynthesis";"Pyridoxal 5'-phosphate salvage II (plants)"
Medex_00083497-RA	1	Reactome: R-HSA-2028269	"Signaling by Hippo"
Medex_00001709-RA	8	KEGG: 04151+2.7.11.1;Reactome: R-HSA-6791226;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04714+2.7.11.1	"PI3K-Akt signaling pathway";"Major pathway of rRNA processing in the nucleolus and cytosol";"Relaxin signaling pathway";"Human cytomegalovirus infection";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"Human papillomavirus infection";"Thermogenesis"
Medex_00024115-RA	4	MetaCyc: PWY-7193;KEGG: 00983+2.7.1.48;KEGG: 00240+2.7.1.48;Reactome: R-HSA-73614	"Pyrimidine ribonucleosides salvage I";"Drug metabolism - other enzymes";"Pyrimidine metabolism";"Pyrimidine salvage"
Medex_00085603-RA	5	Reactome: R-HSA-199220;Reactome: R-HSA-9029558;Reactome: R-HSA-75105;Reactome: R-HSA-2426168;Reactome: R-HSA-163765	"Vitamin B5 (pantothenate) metabolism";"NR1H2 & NR1H3 regulate gene expression linked to lipogenesis";"Fatty acyl-CoA biosynthesis";"Activation of gene expression by SREBF (SREBP)";"ChREBP activates metabolic gene expression"
Medex_00069135-RA	5	Reactome: R-HSA-163765;Reactome: R-HSA-2426168;Reactome: R-HSA-75105;Reactome: R-HSA-9029558;Reactome: R-HSA-199220	"ChREBP activates metabolic gene expression";"Activation of gene expression by SREBF (SREBP)";"Fatty acyl-CoA biosynthesis";"NR1H2 & NR1H3 regulate gene expression linked to lipogenesis";"Vitamin B5 (pantothenate) metabolism"
Medex_00066911-RA	1	Reactome: R-HSA-5389840	"Mitochondrial translation elongation"
Medex_00005867-RA	7	Reactome: R-HSA-1855183;KEGG: 00562+3.1.3.36;KEGG: 04070+3.1.3.36;Reactome: R-HSA-8856828;Reactome: R-HSA-1660499;Reactome: R-HSA-1855204;MetaCyc: PWY-6368	"Synthesis of IP2, IP, and Ins in the cytosol";"Inositol phosphate metabolism";"Phosphatidylinositol signaling system";"Clathrin-mediated endocytosis";"Synthesis of PIPs at the plasma membrane";"Synthesis of IP3 and IP4 in the cytosol";"3-phosphoinositide degradation"
Medex_00014846-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Medex_00069406-RA	2	Reactome: R-HSA-418594;Reactome: R-HSA-375276	"G alpha (i) signalling events";"Peptide ligand-binding receptors"
Medex_00058982-RA	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
Medex_00034040-RA	10	Reactome: R-HSA-3899300;Reactome: R-HSA-427413;Reactome: R-HSA-8936459;Reactome: R-HSA-400206;Reactome: R-HSA-9022538;Reactome: R-HSA-9022692;Reactome: R-HSA-9022702;Reactome: R-HSA-9615017;Reactome: R-HSA-983231;Reactome: R-HSA-9022699	"SUMOylation of transcription cofactors";"NoRC negatively regulates rRNA expression";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Regulation of lipid metabolism by PPARalpha";"Loss of MECP2 binding ability to 5mC-DNA";"Regulation of MECP2 expression and activity";"MECP2 regulates transcription of neuronal ligands";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"Factors involved in megakaryocyte development and platelet production";"MECP2 regulates neuronal receptors and channels"
Medex_00074830-RA	1	KEGG: 00970+6.1.1.7	"Aminoacyl-tRNA biosynthesis"
Medex_00058485-RA	1	Reactome: R-HSA-196836	"Vitamin C (ascorbate) metabolism"
Medex_00005600-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00012499-RA	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
Medex_00028626-RA	14	MetaCyc: PWY-7218;MetaCyc: PWY-5484;KEGG: 00680+4.2.1.11;MetaCyc: PWY-7124;MetaCyc: PWY-8004;MetaCyc: PWY-5723;MetaCyc: PWY-1042;MetaCyc: PWY-6142;KEGG: 00010+4.2.1.11;MetaCyc: PWY-6901;MetaCyc: PWY-7003;MetaCyc: PWY-1622;MetaCyc: PWY-2221;MetaCyc: PWY-6886	"Photosynthetic 3-hydroxybutanoate biosynthesis (engineered)";"Glycolysis II (from fructose 6-phosphate)";"Methane metabolism";"Ethylene biosynthesis V (engineered)";"Entner-Doudoroff pathway I";"Rubisco shunt";"Glycolysis IV (plant cytosol)";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Glycolysis / Gluconeogenesis";"Superpathway of glucose and xylose degradation";"Glycerol degradation to butanol";"Formaldehyde assimilation I (serine pathway)";"Entner-Doudoroff pathway III (semi-phosphorylative)";"1-butanol autotrophic biosynthesis (engineered)"
Medex_00079957-RA	1	Reactome: R-HSA-1799339	"SRP-dependent cotranslational protein targeting to membrane"
Medex_00062042-RA	5	Reactome: R-HSA-390471;Reactome: R-HSA-6814122;Reactome: R-HSA-389957;Reactome: R-HSA-390450;Reactome: R-HSA-389960	"Association of TriC/CCT with target proteins during biosynthesis";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"Prefoldin mediated transfer of substrate to CCT/TriC";"Folding of actin by CCT/TriC";"Formation of tubulin folding intermediates by CCT/TriC"
Medex_00068925-RA	3	KEGG: 00680+3.1.2.12;Reactome: R-HSA-156590;MetaCyc: PWY-1801	"Methane metabolism";"Glutathione conjugation";"Formaldehyde oxidation II (glutathione-dependent)"
Medex_00069580-RA	2	Reactome: R-HSA-1169408;Reactome: R-HSA-168276	"ISG15 antiviral mechanism";"NS1 Mediated Effects on Host Pathways"
Medex_00034490-RA	3	Reactome: R-HSA-189451;KEGG: 00860+1.3.3.4;MetaCyc: PWY-7159	"Heme biosynthesis";"Porphyrin and chlorophyll metabolism";"3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent)"
Medex_00076477-RA	2	Reactome: R-HSA-380270;Reactome: R-HSA-380320	"Recruitment of mitotic centrosome proteins and complexes";"Recruitment of NuMA to mitotic centrosomes"
Medex_00042910-RA	29	Reactome: R-HSA-167160;Reactome: R-HSA-167246;Reactome: R-HSA-167200;Reactome: R-HSA-6782135;Reactome: R-HSA-76042;Reactome: R-HSA-167162;Reactome: R-HSA-75955;Reactome: R-HSA-73776;Reactome: R-HSA-167152;Reactome: R-HSA-674695;Reactome: R-HSA-73863;Reactome: R-HSA-167172;Reactome: R-HSA-6781823;Reactome: R-HSA-73772;Reactome: R-HSA-6782210;Reactome: R-HSA-77075;Reactome: R-HSA-427413;Reactome: R-HSA-6796648;Reactome: R-HSA-5696400;Reactome: R-HSA-73779;Reactome: R-HSA-72086;Reactome: R-HSA-112382;Reactome: R-HSA-73762;Reactome: R-HSA-113418;Reactome: R-HSA-5696395;Reactome: R-HSA-167158;Reactome: R-HSA-75953;Reactome: R-HSA-6781827;Reactome: R-HSA-167161	"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Tat-mediated elongation of the HIV-1 transcript";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Dual incision in TC-NER";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Elongation";"RNA Polymerase II Promoter Escape";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase I Transcription Termination";"Transcription of the HIV genome";"Formation of TC-NER Pre-Incision Complex";"RNA Polymerase I Promoter Escape";"Gap-filling DNA repair synthesis and ligation in TC-NER";"RNA Pol II CTD phosphorylation and interaction with CE";"NoRC negatively regulates rRNA expression";"TP53 Regulates Transcription of DNA Repair Genes";"Dual Incision in GG-NER";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"mRNA Capping";"Formation of RNA Pol II elongation complex";"RNA Polymerase I Transcription Initiation";"Formation of the Early Elongation Complex";"Formation of Incision Complex in GG-NER";"Formation of the HIV-1 Early Elongation Complex";"RNA Polymerase II Transcription Initiation";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"HIV Transcription Initiation"
Medex_00016177-RA	4	Reactome: R-HSA-2022090;Reactome: R-HSA-8948216;Reactome: R-HSA-1442490;Reactome: R-HSA-1650814	"Assembly of collagen fibrils and other multimeric structures";"Collagen chain trimerization";"Collagen degradation";"Collagen biosynthesis and modifying enzymes"
Medex_00096294-RA	1	Reactome: R-HSA-196783	"Coenzyme A biosynthesis"
Medex_00060788-RA	17	MetaCyc: PWY-6728;MetaCyc: PWY-5690;MetaCyc: PWY-5392;MetaCyc: PWY-561;KEGG: 00620+1.1.1.37;KEGG: 00630+1.1.1.37;KEGG: 00720+1.1.1.37;KEGG: 00270+1.1.1.37;MetaCyc: PWY-6969;MetaCyc: PWY-5913;KEGG: 00710+1.1.1.37;MetaCyc: PWY-8086;MetaCyc: PWY-1622;KEGG: 00680+1.1.1.37;MetaCyc: PWY-7115;MetaCyc: PWY-7383;KEGG: 00020+1.1.1.37	"Methylaspartate cycle";"TCA cycle II (plants and fungi)";"Reductive TCA cycle II";"Superpathway of glyoxylate cycle and fatty acid degradation";"Pyruvate metabolism";"Glyoxylate and dicarboxylate metabolism";"Carbon fixation pathways in prokaryotes";"Cysteine and methionine metabolism";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Partial TCA cycle (obligate autotrophs)";"Carbon fixation in photosynthetic organisms";"(S)-lactate fermentation to propanoate, acetate and hydrogen";"Formaldehyde assimilation I (serine pathway)";"Methane metabolism";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"Anaerobic energy metabolism (invertebrates, cytosol)";"Citrate cycle (TCA cycle)"
Medex_00019607-RA	2	Reactome: R-HSA-8876198;Reactome: R-HSA-6811436	"RAB GEFs exchange GTP for GDP on RABs";"COPI-independent Golgi-to-ER retrograde traffic"
Medex_00045472-RA	3	Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-212436	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"Generic Transcription Pathway"
Medex_00081330-RA	7	Reactome: R-HSA-5620912;Reactome: R-HSA-380284;Reactome: R-HSA-2565942;Reactome: R-HSA-380259;Reactome: R-HSA-8854518;Reactome: R-HSA-380320;Reactome: R-HSA-380270	"Anchoring of the basal body to the plasma membrane";"Loss of proteins required for interphase microtubule organization from the centrosome";"Regulation of PLK1 Activity at G2/M Transition";"Loss of Nlp from mitotic centrosomes";"AURKA Activation by TPX2";"Recruitment of NuMA to mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes"
Medex_00049820-RA	1	KEGG: 00480+3.4.11.1	"Glutathione metabolism"
Medex_00001440-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00052143-RA	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
Medex_00032506-RA	7	KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1	"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Thermogenesis";"Relaxin signaling pathway";"Human cytomegalovirus infection"
Medex_00006774-RA	4	Reactome: R-HSA-2160916;Reactome: R-HSA-2206292;Reactome: R-HSA-2024096;Reactome: R-HSA-6798695	"Hyaluronan uptake and degradation";"MPS VII - Sly syndrome";"HS-GAG degradation";"Neutrophil degranulation"
Medex_00004706-RA	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
Medex_00091664-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00069447-RA	1	Reactome: R-HSA-8854691	"Interleukin-20 family signaling"
Medex_00004944-RA	1	Reactome: R-HSA-211981	"Xenobiotics"
Medex_00017968-RA	5	Reactome: R-HSA-390471;Reactome: R-HSA-389957;Reactome: R-HSA-6814122;Reactome: R-HSA-390450;Reactome: R-HSA-389960	"Association of TriC/CCT with target proteins during biosynthesis";"Prefoldin mediated transfer of substrate to CCT/TriC";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"Folding of actin by CCT/TriC";"Formation of tubulin folding intermediates by CCT/TriC"
Medex_00021329-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00034970-RA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
Medex_00063082-RA	2	Reactome: R-HSA-1660661;KEGG: 04070+2.7.11.13	"Sphingolipid de novo biosynthesis";"Phosphatidylinositol signaling system"
Medex_00030760-RA	2	Reactome: R-HSA-1660662;Reactome: R-HSA-390471	"Glycosphingolipid metabolism";"Association of TriC/CCT with target proteins during biosynthesis"
Medex_00014992-RA	1	Reactome: R-HSA-429958	"mRNA decay by 3' to 5' exoribonuclease"
Medex_00047742-RA	3	MetaCyc: PWY-6348;KEGG: 00730+3.1.3.2;KEGG: 00740+3.1.3.2	"Phosphate acquisition";"Thiamine metabolism";"Riboflavin metabolism"
Medex_00001933-RA	14	Reactome: R-HSA-69091;Reactome: R-HSA-5656169;Reactome: R-HSA-110320;Reactome: R-HSA-5651801;Reactome: R-HSA-6782135;Reactome: R-HSA-174411;Reactome: R-HSA-110314;Reactome: R-HSA-5655862;Reactome: R-HSA-5696400;Reactome: R-HSA-5696397;Reactome: R-HSA-110312;Reactome: R-HSA-5685942;Reactome: R-HSA-5656121;Reactome: R-HSA-6782210	"Polymerase switching";"Termination of translesion DNA synthesis";"Translesion Synthesis by POLH";"PCNA-Dependent Long Patch Base Excision Repair";"Dual incision in TC-NER";"Polymerase switching on the C-strand of the telomere";"Recognition of DNA damage by PCNA-containing replication complex";"Translesion synthesis by POLK";"Dual Incision in GG-NER";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Translesion synthesis by REV1";"HDR through Homologous Recombination (HRR)";"Translesion synthesis by POLI";"Gap-filling DNA repair synthesis and ligation in TC-NER"
Medex_00000556-RA	1	KEGG: 00480+3.4.11.2	"Glutathione metabolism"
Medex_00058751-RA	2	Reactome: R-HSA-2408508;Reactome: R-HSA-389661	"Metabolism of ingested SeMet, Sec, MeSec into H2Se";"Glyoxylate metabolism and glycine degradation"
Medex_00017030-RA	6	Reactome: R-HSA-176974;Reactome: R-HSA-68962;Reactome: R-HSA-176187;Reactome: R-HSA-69052;Reactome: R-HSA-68867;Reactome: R-HSA-68949	"Unwinding of DNA";"Activation of the pre-replicative complex";"Activation of ATR in response to replication stress";"Switching of origins to a post-replicative state";"Assembly of the pre-replicative complex";"Orc1 removal from chromatin"
Medex_00016295-RA	6	Reactome: R-HSA-112382;Reactome: R-HSA-8866654;Reactome: R-HSA-75955;Reactome: R-HSA-5632684;Reactome: R-HSA-201722;Reactome: R-HSA-674695	"Formation of RNA Pol II elongation complex";"E3 ubiquitin ligases ubiquitinate target proteins";"RNA Polymerase II Transcription Elongation";"Hedgehog 'on' state";"Formation of the beta-catenin:TCF transactivating complex";"RNA Polymerase II Pre-transcription Events"
Medex_00054929-RA	1	Reactome: R-HSA-425381	"Bicarbonate transporters"
Medex_00021088-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Medex_00045199-RA	4	Reactome: R-HSA-180024;KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16	"DARPP-32 events";"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation"
Medex_00051981-RA	1	Reactome: R-HSA-3295583	"TRP channels"
Medex_00021527-RA	2	Reactome: R-HSA-8866654;MetaCyc: PWY-7511	"E3 ubiquitin ligases ubiquitinate target proteins";"Protein ubiquitination"
Medex_00046721-RA	2	KEGG: 00970+6.1.1.20;Reactome: R-HSA-379716	"Aminoacyl-tRNA biosynthesis";"Cytosolic tRNA aminoacylation"
Medex_00032190-RA	10	KEGG: 00604+3.2.1.23;MetaCyc: PWY-6807;KEGG: 00511+3.2.1.23;Reactome: R-HSA-2024096;Reactome: R-HSA-2206292;Reactome: R-HSA-2160916;KEGG: 00600+3.2.1.23;Reactome: R-HSA-6798695;KEGG: 00531+3.2.1.23;KEGG: 00052+3.2.1.23	"Glycosphingolipid biosynthesis - ganglio series";"Xyloglucan degradation II (exoglucanase)";"Other glycan degradation";"HS-GAG degradation";"MPS VII - Sly syndrome";"Hyaluronan uptake and degradation";"Sphingolipid metabolism";"Neutrophil degranulation";"Glycosaminoglycan degradation";"Galactose metabolism"
Medex_00040031-RA	1	Reactome: R-HSA-163125	"Post-translational modification: synthesis of GPI-anchored proteins"
Medex_00028437-RA	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
Medex_00023803-RA	10	MetaCyc: PWY-5667;MetaCyc: PWY-8055;KEGG: 00561+2.3.1.15;MetaCyc: PWY-7411;MetaCyc: PWY-7587;MetaCyc: PWY-8053;Reactome: R-HSA-1483166;MetaCyc: PWY-8051;KEGG: 00564+2.3.1.15;MetaCyc: PWY-6453	"CDP-diacylglycerol biosynthesis I";"Palmitoyl ethanolamide biosynthesis";"Glycerolipid metabolism";"Phosphatidate biosynthesis (yeast)";"Oleate biosynthesis III (cyanobacteria)";"Anandamide biosynthesis II";"Synthesis of PA";"Anandamide biosynthesis I";"Glycerophospholipid metabolism";"Stigma estolide biosynthesis"
Medex_00004387-RA	6	KEGG: 00604+3.2.1.23;KEGG: 00600+3.2.1.23;KEGG: 00511+3.2.1.23;MetaCyc: PWY-6807;KEGG: 00052+3.2.1.23;KEGG: 00531+3.2.1.23	"Glycosphingolipid biosynthesis - ganglio series";"Sphingolipid metabolism";"Other glycan degradation";"Xyloglucan degradation II (exoglucanase)";"Galactose metabolism";"Glycosaminoglycan degradation"
Medex_00069216-RA	4	Reactome: R-HSA-1369062;Reactome: R-HSA-5683678;Reactome: R-HSA-5683826;Reactome: R-HSA-5688399	"ABC transporters in lipid homeostasis";"Defective ABCA3 causes pulmonary surfactant metabolism dysfunction type 3 (SMDP3)";"Surfactant metabolism";"Defective ABCA3 causes pulmonary surfactant metabolism dysfunction 3 (SMDP3)"
Medex_00048404-RA	2	KEGG: 00340+2.1.1.22;Reactome: R-HSA-70921	"Histidine metabolism";"Histidine catabolism"
Medex_00056994-RA	1	Reactome: R-HSA-1632852	"Macroautophagy"
Medex_00016290-RA	6	Reactome: R-HSA-112382;Reactome: R-HSA-75955;Reactome: R-HSA-8866654;Reactome: R-HSA-5632684;Reactome: R-HSA-201722;Reactome: R-HSA-674695	"Formation of RNA Pol II elongation complex";"RNA Polymerase II Transcription Elongation";"E3 ubiquitin ligases ubiquitinate target proteins";"Hedgehog 'on' state";"Formation of the beta-catenin:TCF transactivating complex";"RNA Polymerase II Pre-transcription Events"
Medex_00026109-RA	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
Medex_00036022-RA	5	KEGG: 00052+3.2.1.22;KEGG: 00603+3.2.1.22;KEGG: 00600+3.2.1.22;KEGG: 00561+3.2.1.22;MetaCyc: PWY-6527	"Galactose metabolism";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Sphingolipid metabolism";"Glycerolipid metabolism";"Stachyose degradation"
Medex_00094089-RA	5	Reactome: R-HSA-9610379;Reactome: R-HSA-917729;Reactome: R-HSA-9615710;Reactome: R-HSA-174490;Reactome: R-HSA-162588	"HCMV Late Events";"Endosomal Sorting Complex Required For Transport (ESCRT)";"Late endosomal microautophagy";"Membrane binding and targetting of GAG proteins";"Budding and maturation of HIV virion"
Medex_00055775-RA	3	Reactome: R-HSA-201722;Reactome: R-HSA-3214847;Reactome: R-HSA-5689880	"Formation of the beta-catenin:TCF transactivating complex";"HATs acetylate histones";"Ub-specific processing proteases"
Medex_00036028-RA	57	Reactome: R-HSA-8854050;Reactome: R-HSA-1236974;Reactome: R-HSA-5610783;Reactome: R-HSA-174084;Reactome: R-HSA-187577;Reactome: R-HSA-2871837;Reactome: R-HSA-8951664;Reactome: R-HSA-174184;Reactome: R-HSA-5607764;Reactome: R-HSA-174154;Reactome: R-HSA-1169091;Reactome: R-HSA-8948751;Reactome: R-HSA-9604323;Reactome: R-HSA-68827;Reactome: R-HSA-5676590;Reactome: R-HSA-69601;Reactome: R-HSA-5362768;Reactome: R-HSA-69017;Reactome: R-HSA-1234176;Reactome: R-HSA-4641257;Reactome: R-HSA-174113;Reactome: R-HSA-350562;Reactome: R-HSA-69481;Reactome: R-HSA-5678895;Reactome: R-HSA-211733;Reactome: R-HSA-8939236;Reactome: R-HSA-68949;Reactome: R-HSA-382556;Reactome: R-HSA-9010553;Reactome: R-HSA-450408;Reactome: R-HSA-180585;Reactome: R-HSA-2467813;Reactome: R-HSA-4641258;Reactome: R-HSA-6798695;Reactome: R-HSA-9020702;Reactome: R-HSA-202424;Reactome: R-HSA-983168;Reactome: R-HSA-5358346;Reactome: R-HSA-8941858;Reactome: R-HSA-5658442;Reactome: R-HSA-174178;Reactome: R-HSA-8852276;Reactome: R-HSA-5610780;Reactome: R-HSA-5607761;Reactome: R-HSA-180534;Reactome: R-HSA-349425;Reactome: R-HSA-1236978;Reactome: R-HSA-5632684;Reactome: R-HSA-4608870;Reactome: R-HSA-5668541;Reactome: R-HSA-5687128;Reactome: R-HSA-5689603;Reactome: R-HSA-5610785;Reactome: R-HSA-5689880;Reactome: R-HSA-195253;Reactome: R-HSA-75815;Reactome: R-HSA-8939902	"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"ER-Phagosome pathway";"Degradation of GLI2 by the proteasome";"Autodegradation of Cdh1 by Cdh1:APC/C";"SCF(Skp2)-mediated degradation of p27/p21";"FCERI mediated NF-kB activation";"Neddylation";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"CLEC7A (Dectin-1) signaling";"APC/C:Cdc20 mediated degradation of Securin";"Activation of NF-kappaB in B cells";"Regulation of PTEN stability and activity";"Negative regulation of NOTCH4 signaling";"CDT1 association with the CDC6:ORC:origin complex";"NIK-->noncanonical NF-kB signaling";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"CDK-mediated phosphorylation and removal of Cdc6";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Degradation of AXIN";"SCF-beta-TrCP mediated degradation of Emi1";"Regulation of ornithine decarboxylase (ODC)";"G2/M Checkpoints";"Defective CFTR causes cystic fibrosis";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Orc1 removal from chromatin";"ABC-family proteins mediated transport";"Regulation of expression of SLITs and ROBOs";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Vif-mediated degradation of APOBEC3G";"Separation of Sister Chromatids";"Degradation of DVL";"Neutrophil degranulation";"Interleukin-1 signaling";"Downstream TCR signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Hedgehog ligand biogenesis";"Regulation of RUNX3 expression and activity";"Regulation of RAS by GAPs";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Degradation of GLI1 by the proteasome";"Dectin-1 mediated noncanonical NF-kB signaling";"Vpu mediated degradation of CD4";"Autodegradation of the E3 ubiquitin ligase COP1";"Cross-presentation of soluble exogenous antigens (endosomes)";"Hedgehog 'on' state";"Asymmetric localization of PCP proteins";"TNFR2 non-canonical NF-kB pathway";"MAPK6/MAPK4 signaling";"UCH proteinases";"GLI3 is processed to GLI3R by the proteasome";"Ub-specific processing proteases";"Degradation of beta-catenin by the destruction complex";"Ubiquitin-dependent degradation of Cyclin D";"Regulation of RUNX2 expression and activity"
Medex_00054784-RA	56	Reactome: R-HSA-5632684;Reactome: R-HSA-349425;Reactome: R-HSA-1236978;Reactome: R-HSA-180534;Reactome: R-HSA-5607761;Reactome: R-HSA-5610780;Reactome: R-HSA-8852276;Reactome: R-HSA-174178;Reactome: R-HSA-8939902;Reactome: R-HSA-75815;Reactome: R-HSA-195253;Reactome: R-HSA-5610785;Reactome: R-HSA-5689880;Reactome: R-HSA-5668541;Reactome: R-HSA-5689603;Reactome: R-HSA-5687128;Reactome: R-HSA-4608870;Reactome: R-HSA-4641258;Reactome: R-HSA-2467813;Reactome: R-HSA-180585;Reactome: R-HSA-450408;Reactome: R-HSA-9010553;Reactome: R-HSA-68949;Reactome: R-HSA-8939236;Reactome: R-HSA-382556;Reactome: R-HSA-211733;Reactome: R-HSA-5658442;Reactome: R-HSA-8941858;Reactome: R-HSA-5358346;Reactome: R-HSA-983168;Reactome: R-HSA-202424;Reactome: R-HSA-9020702;Reactome: R-HSA-1169091;Reactome: R-HSA-174154;Reactome: R-HSA-174184;Reactome: R-HSA-5607764;Reactome: R-HSA-8951664;Reactome: R-HSA-2871837;Reactome: R-HSA-5678895;Reactome: R-HSA-350562;Reactome: R-HSA-69481;Reactome: R-HSA-174113;Reactome: R-HSA-4641257;Reactome: R-HSA-5362768;Reactome: R-HSA-1234176;Reactome: R-HSA-69601;Reactome: R-HSA-69017;Reactome: R-HSA-5676590;Reactome: R-HSA-9604323;Reactome: R-HSA-8948751;Reactome: R-HSA-68827;Reactome: R-HSA-5610783;Reactome: R-HSA-1236974;Reactome: R-HSA-8854050;Reactome: R-HSA-187577;Reactome: R-HSA-174084	"Hedgehog 'on' state";"Autodegradation of the E3 ubiquitin ligase COP1";"Cross-presentation of soluble exogenous antigens (endosomes)";"Vpu mediated degradation of CD4";"Dectin-1 mediated noncanonical NF-kB signaling";"Degradation of GLI1 by the proteasome";"The role of GTSE1 in G2/M progression after G2 checkpoint";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Regulation of RUNX2 expression and activity";"Ubiquitin-dependent degradation of Cyclin D";"Degradation of beta-catenin by the destruction complex";"GLI3 is processed to GLI3R by the proteasome";"Ub-specific processing proteases";"TNFR2 non-canonical NF-kB pathway";"UCH proteinases";"MAPK6/MAPK4 signaling";"Asymmetric localization of PCP proteins";"Degradation of DVL";"Separation of Sister Chromatids";"Vif-mediated degradation of APOBEC3G";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Regulation of expression of SLITs and ROBOs";"Orc1 removal from chromatin";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"ABC-family proteins mediated transport";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Regulation of RAS by GAPs";"Regulation of RUNX3 expression and activity";"Hedgehog ligand biogenesis";"Antigen processing: Ubiquitination & Proteasome degradation";"Downstream TCR signaling";"Interleukin-1 signaling";"Activation of NF-kappaB in B cells";"APC/C:Cdc20 mediated degradation of Securin";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"CLEC7A (Dectin-1) signaling";"Neddylation";"FCERI mediated NF-kB activation";"Defective CFTR causes cystic fibrosis";"Regulation of ornithine decarboxylase (ODC)";"G2/M Checkpoints";"SCF-beta-TrCP mediated degradation of Emi1";"Degradation of AXIN";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"CDK-mediated phosphorylation and removal of Cdc6";"NIK-->noncanonical NF-kB signaling";"Negative regulation of NOTCH4 signaling";"Regulation of PTEN stability and activity";"CDT1 association with the CDC6:ORC:origin complex";"Degradation of GLI2 by the proteasome";"ER-Phagosome pathway";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"SCF(Skp2)-mediated degradation of p27/p21";"Autodegradation of Cdh1 by Cdh1:APC/C"
Medex_00091400-RA	2	Reactome: R-HSA-983168;Reactome: R-HSA-9635465	"Antigen processing: Ubiquitination & Proteasome degradation";"Suppression of apoptosis"
Medex_00039266-RA	2	Reactome: R-HSA-983168;Reactome: R-HSA-8951664	"Antigen processing: Ubiquitination & Proteasome degradation";"Neddylation"
Medex_00000490-RA	2	Reactome: R-HSA-390471;Reactome: R-HSA-1660662	"Association of TriC/CCT with target proteins during biosynthesis";"Glycosphingolipid metabolism"
Medex_00018014-RA	2	Reactome: R-HSA-5693571;Reactome: R-HSA-164843	"Nonhomologous End-Joining (NHEJ)";"2-LTR circle formation"
Medex_00089435-RA	1	Reactome: R-HSA-196843	"Vitamin B2 (riboflavin) metabolism"
Medex_00027631-RA	2	Reactome: R-HSA-380270;Reactome: R-HSA-380320	"Recruitment of mitotic centrosome proteins and complexes";"Recruitment of NuMA to mitotic centrosomes"
Medex_00077353-RA	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
Medex_00031609-RA	7	Reactome: R-HSA-69205;Reactome: R-HSA-1362300;Reactome: R-HSA-69656;Reactome: R-HSA-1538133;Reactome: R-HSA-156711;Reactome: R-HSA-1362277;Reactome: R-HSA-69202	"G1/S-Specific Transcription";"Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1";"Cyclin A:Cdk2-associated events at S phase entry";"G0 and Early G1";"Polo-like kinase mediated events";"Transcription of E2F targets under negative control by DREAM complex";"Cyclin E associated events during G1/S transition"
Medex_00024728-RA	1	Reactome: R-HSA-975957	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
Medex_00065913-RA	7	Reactome: R-HSA-1855204;KEGG: 00562+3.1.4.11;MetaCyc: PWY-7039;MetaCyc: PWY-6351;MetaCyc: PWY-6367;KEGG: 04070+3.1.4.11;MetaCyc: PWY-8052	"Synthesis of IP3 and IP4 in the cytosol";"Inositol phosphate metabolism";"Phosphatidate metabolism, as a signaling molecule";"D-myo-inositol (1,4,5)-trisphosphate biosynthesis";"D-myo-inositol-5-phosphate metabolism";"Phosphatidylinositol signaling system";"2-arachidonoylglycerol biosynthesis"
Medex_00017382-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Medex_00003839-RA	16	Reactome: R-HSA-2467813;Reactome: R-HSA-176409;Reactome: R-HSA-179409;Reactome: R-HSA-141430;Reactome: R-HSA-983168;Reactome: R-HSA-174048;Reactome: R-HSA-176408;Reactome: R-HSA-2559582;Reactome: R-HSA-174084;Reactome: R-HSA-8853884;Reactome: R-HSA-174154;Reactome: R-HSA-174184;Reactome: R-HSA-174178;Reactome: R-HSA-176412;Reactome: R-HSA-176407;Reactome: R-HSA-69017	"Separation of Sister Chromatids";"APC/C:Cdc20 mediated degradation of mitotic proteins";"APC-Cdc20 mediated degradation of Nek2A";"Inactivation of APC/C via direct inhibition of the APC/C complex";"Antigen processing: Ubiquitination & Proteasome degradation";"APC/C:Cdc20 mediated degradation of Cyclin B";"Regulation of APC/C activators between G1/S and early anaphase";"Senescence-Associated Secretory Phenotype (SASP)";"Autodegradation of Cdh1 by Cdh1:APC/C";"Transcriptional Regulation by VENTX";"APC/C:Cdc20 mediated degradation of Securin";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Phosphorylation of the APC/C";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"CDK-mediated phosphorylation and removal of Cdc6"
Medex_00006591-RA	27	Reactome: R-HSA-4570464;Reactome: R-HSA-170822;Reactome: R-HSA-4085377;Reactome: R-HSA-3301854;Reactome: R-HSA-3232142;Reactome: R-HSA-180910;Reactome: R-HSA-168271;Reactome: R-HSA-159236;Reactome: R-HSA-191859;Reactome: R-HSA-168325;Reactome: R-HSA-6784531;Reactome: R-HSA-3108214;Reactome: R-HSA-9609690;Reactome: R-HSA-4551638;Reactome: R-HSA-5619107;Reactome: R-HSA-9610379;Reactome: R-HSA-159227;Reactome: R-HSA-180746;Reactome: R-HSA-159231;Reactome: R-HSA-165054;Reactome: R-HSA-168333;Reactome: R-HSA-1169408;Reactome: R-HSA-168276;Reactome: R-HSA-5578749;Reactome: R-HSA-3371453;Reactome: R-HSA-159230;Reactome: R-HSA-4615885	"SUMOylation of RNA binding proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"SUMOylation of SUMOylation proteins";"Nuclear Pore Complex (NPC) Disassembly";"SUMOylation of ubiquitinylation proteins";"Vpr-mediated nuclear import of PICs";"Transport of Ribonucleoproteins into the Host Nucleus";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"snRNP Assembly";"Viral Messenger RNA Synthesis";"tRNA processing in the nucleus";"SUMOylation of DNA damage response and repair proteins";"HCMV Early Events";"SUMOylation of chromatin organization proteins";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"HCMV Late Events";"Transport of the SLBP independent Mature mRNA";"Nuclear import of Rev protein";"Transport of Mature mRNA Derived from an Intronless Transcript";"Rev-mediated nuclear export of HIV RNA";"NEP/NS2 Interacts with the Cellular Export Machinery";"ISG15 antiviral mechanism";"NS1 Mediated Effects on Host Pathways";"Transcriptional regulation by small RNAs";"Regulation of HSF1-mediated heat shock response";"Transport of the SLBP Dependant Mature mRNA";"SUMOylation of DNA replication proteins"
Medex_00053150-RA	4	Reactome: R-HSA-77387;Reactome: R-HSA-983712;Reactome: R-HSA-1222556;Reactome: R-HSA-917977	"Insulin receptor recycling";"Ion channel transport";"ROS and RNS production in phagocytes";"Transferrin endocytosis and recycling"
Medex_00054720-RA	4	Reactome: R-HSA-112382;Reactome: R-HSA-75955;Reactome: R-HSA-8866654;Reactome: R-HSA-674695	"Formation of RNA Pol II elongation complex";"RNA Polymerase II Transcription Elongation";"E3 ubiquitin ligases ubiquitinate target proteins";"RNA Polymerase II Pre-transcription Events"
Medex_00079585-RA	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
Medex_00089395-RA	1	Reactome: R-HSA-6798163	"Choline catabolism"
Medex_00031255-RA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
Medex_00076174-RA	13	KEGG: 00603+3.2.1.52;MetaCyc: PWY-6902;MetaCyc: PWY-7883;Reactome: R-HSA-2160916;KEGG: 00520+3.2.1.52;KEGG: 00531+3.2.1.52;MetaCyc: PWY-7822;KEGG: 00513+3.2.1.52;KEGG: 00511+3.2.1.52;Reactome: R-HSA-2022857;KEGG: 00604+3.2.1.52;Reactome: R-HSA-1660662;Reactome: R-HSA-2024101	"Glycosphingolipid biosynthesis - globo and isoglobo series";"Chitin degradation II (Vibrio)";"Anhydromuropeptides recycling II";"Hyaluronan uptake and degradation";"Amino sugar and nucleotide sugar metabolism";"Glycosaminoglycan degradation";"Chitin degradation III (Serratia)";"Various types of N-glycan biosynthesis";"Other glycan degradation";"Keratan sulfate degradation";"Glycosphingolipid biosynthesis - ganglio series";"Glycosphingolipid metabolism";"CS/DS degradation"
Medex_00002835-RA	1	Reactome: R-HSA-71403	"Citric acid cycle (TCA cycle)"
Medex_00093686-RA	14	Reactome: R-HSA-9648025;Reactome: R-HSA-68877;Reactome: R-HSA-9634638;Reactome: R-HSA-3769402;Reactome: R-HSA-2467813;Reactome: R-HSA-168333;Reactome: R-HSA-165054;Reactome: R-HSA-69273;Reactome: R-HSA-2500257;Reactome: R-HSA-141444;Reactome: R-HSA-2173788;Reactome: R-HSA-5687128;Reactome: R-HSA-5663220;Reactome: R-HSA-450520	"EML4 and NUDC in mitotic spindle formation";"Mitotic Prometaphase";"Estrogen-dependent nuclear events downstream of ESR-membrane signaling";"Deactivation of the beta-catenin transactivating complex";"Separation of Sister Chromatids";"NEP/NS2 Interacts with the Cellular Export Machinery";"Rev-mediated nuclear export of HIV RNA";"Cyclin A/B1/B2 associated events during G2/M transition";"Resolution of Sister Chromatid Cohesion";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Downregulation of TGF-beta receptor signaling";"MAPK6/MAPK4 signaling";"RHO GTPases Activate Formins";"HuR (ELAVL1) binds and stabilizes mRNA"
Medex_00087256-RA	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
Medex_00052545-RA	2	Reactome: R-HSA-3214858;Reactome: R-HSA-8939243	"RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"
Medex_00039149-RA	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
Medex_00071876-RA	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276	"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination"
Medex_00036986-RA	5	MetaCyc: PWY-7979;KEGG: 00514+2.4.1.109;KEGG: 00515+2.4.1.109;MetaCyc: PWY-7922;MetaCyc: PWY-7921	"Protein O-mannosylation III (mammals, core M3)";"Other types of O-glycan biosynthesis";"Mannose type O-glycan biosynthesis";"Protein O-mannosylation II (mammals, core M1 and core M2)";"Protein O-mannosylation I (yeast)"
Medex_00053564-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00069745-RA	5	Reactome: R-HSA-196757;KEGG: 00670+1.5.1.20;MetaCyc: PWY-3841;KEGG: 00720+1.5.1.20;MetaCyc: PWY-2201	"Metabolism of folate and pterines";"One carbon pool by folate";"Folate transformations II (plants)";"Carbon fixation pathways in prokaryotes";"Folate transformations I"
Medex_00087603-RA	1	Reactome: R-HSA-2151201	"Transcriptional activation of mitochondrial biogenesis"
Medex_00072270-RA	7	KEGG: 00020+2.3.1.12;Reactome: R-HSA-204174;Reactome: R-HSA-70268;Reactome: R-HSA-5362517;KEGG: 00010+2.3.1.12;KEGG: 00620+2.3.1.12;Reactome: R-HSA-389661	"Citrate cycle (TCA cycle)";"Regulation of pyruvate dehydrogenase (PDH) complex";"Pyruvate metabolism";"Signaling by Retinoic Acid";"Glycolysis / Gluconeogenesis";"Pyruvate metabolism";"Glyoxylate metabolism and glycine degradation"
Medex_00096110-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00010009-RA	1	Reactome: R-HSA-2559584	"Formation of Senescence-Associated Heterochromatin Foci (SAHF)"
Medex_00071239-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00026419-RA	5	Reactome: R-HSA-6802946;Reactome: R-HSA-9649948;Reactome: R-HSA-5675221;Reactome: R-HSA-6802955;Reactome: R-HSA-5673000	"Signaling by moderate kinase activity BRAF mutants";"Signaling downstream of RAS mutants";"Negative regulation of MAPK pathway";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"RAF activation"
Medex_00097714-RA	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840	"Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation"
Medex_00039259-RA	1	Reactome: R-HSA-4615885	"SUMOylation of DNA replication proteins"
Medex_00072869-RA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
Medex_00057700-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Medex_00019340-RA	1	KEGG: 00970+6.1.1.9	"Aminoacyl-tRNA biosynthesis"
Medex_00054967-RA	3	Reactome: R-HSA-6798695;MetaCyc: PWY-6807;KEGG: 00511+3.2.1.51	"Neutrophil degranulation";"Xyloglucan degradation II (exoglucanase)";"Other glycan degradation"
Medex_00054558-RA	1	Reactome: R-HSA-6804760	"Regulation of TP53 Activity through Methylation"
Medex_00047229-RA	1	Reactome: R-HSA-1614517	"Sulfide oxidation to sulfate"
Medex_00011738-RA	2	Reactome: R-HSA-429947;Reactome: R-HSA-6804115	"Deadenylation of mRNA";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"
Medex_00087394-RA	4	Reactome: R-HSA-9010553;Reactome: R-HSA-975957;Reactome: R-HSA-975956;Reactome: R-HSA-72764	"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination"
Medex_00001585-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00005651-RA	1	Reactome: R-HSA-216083	"Integrin cell surface interactions"
Medex_00027429-RA	1	Reactome: R-HSA-8876725	"Protein methylation"
Medex_00054150-RA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
Medex_00022301-RA	6	KEGG: 00500+2.4.1.18;MetaCyc: PWY-5067;MetaCyc: PWY-7900;Reactome: R-HSA-3322077;Reactome: R-HSA-3878781;MetaCyc: PWY-622	"Starch and sucrose metabolism";"Glycogen biosynthesis II (from UDP-D-Glucose)";"Glycogen biosynthesis III (from alpha-maltose 1-phosphate)";"Glycogen synthesis";"Glycogen storage disease type IV (GBE1)";"Starch biosynthesis"
Medex_00049529-RA	1	Reactome: R-HSA-5693607	"Processing of DNA double-strand break ends"
Medex_00058309-RA	1	Reactome: R-HSA-264876	"Insulin processing"
Medex_00017444-RA	5	Reactome: R-HSA-196025;Reactome: R-HSA-8856828;Reactome: R-HSA-190873;Reactome: R-HSA-3928665;Reactome: R-HSA-8856825	"Formation of annular gap junctions";"Clathrin-mediated endocytosis";"Gap junction degradation";"EPH-ephrin mediated repulsion of cells";"Cargo recognition for clathrin-mediated endocytosis"
Medex_00016630-RA	10	KEGG: 00052+2.7.1.11;MetaCyc: PWY-1861;KEGG: 00680+2.7.1.11;MetaCyc: PWY-5484;KEGG: 00030+2.7.1.11;KEGG: 00010+2.7.1.11;KEGG: 00051+2.7.1.11;MetaCyc: PWY-7385;MetaCyc: PWY-1042;Reactome: R-HSA-70171	"Galactose metabolism";"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"Methane metabolism";"Glycolysis II (from fructose 6-phosphate)";"Pentose phosphate pathway";"Glycolysis / Gluconeogenesis";"Fructose and mannose metabolism";"1,3-propanediol biosynthesis (engineered)";"Glycolysis IV (plant cytosol)";"Glycolysis"
Medex_00072868-RA	6	MetaCyc: PWY-6807;KEGG: 00600+3.2.1.23;KEGG: 00511+3.2.1.23;KEGG: 00604+3.2.1.23;KEGG: 00052+3.2.1.23;KEGG: 00531+3.2.1.23	"Xyloglucan degradation II (exoglucanase)";"Sphingolipid metabolism";"Other glycan degradation";"Glycosphingolipid biosynthesis - ganglio series";"Galactose metabolism";"Glycosaminoglycan degradation"
Medex_00003731-RA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
Medex_00008744-RA	3	Reactome: R-HSA-2142691;MetaCyc: PWY-7533;Reactome: R-HSA-5423646	"Synthesis of Leukotrienes (LT) and Eoxins (EX)";"Gliotoxin biosynthesis";"Aflatoxin activation and detoxification"
Medex_00080714-RA	7	KEGG: 00500+2.4.1.25;MetaCyc: PWY-5941;MetaCyc: PWY-6737;MetaCyc: PWY-7238;Reactome: R-HSA-70221;Reactome: R-HSA-6798695;MetaCyc: PWY-6724	"Starch and sucrose metabolism";"Glycogen degradation II";"Starch degradation V";"Sucrose biosynthesis II";"Glycogen breakdown (glycogenolysis)";"Neutrophil degranulation";"Starch degradation II"
Medex_00050961-RA	14	MetaCyc: PWY-8051;MetaCyc: PWY-7409;MetaCyc: PWY-6803;Reactome: R-HSA-975634;KEGG: 00590+3.1.1.4;KEGG: 00565+3.1.1.4;MetaCyc: PWY-7416;MetaCyc: PWY-8053;MetaCyc: PWY-7417;KEGG: 00591+3.1.1.4;KEGG: 00592+3.1.1.4;KEGG: 00564+3.1.1.4+3.1.1.5;Reactome: R-HSA-1482788;MetaCyc: PWY-7783	"Anandamide biosynthesis I";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Phosphatidylcholine acyl editing";"Retinoid metabolism and transport";"Arachidonic acid metabolism";"Ether lipid metabolism";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Anandamide biosynthesis II";"Phospholipid remodeling (phosphatidate, yeast)";"Linoleic acid metabolism";"alpha-Linolenic acid metabolism";"Glycerophospholipid metabolism";"Acyl chain remodelling of PC";"Plasmalogen degradation"
Medex_00067549-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Medex_00030938-RA	2	Reactome: R-HSA-1660662;Reactome: R-HSA-390471	"Glycosphingolipid metabolism";"Association of TriC/CCT with target proteins during biosynthesis"
Medex_00080469-RA	1	KEGG: 00760+2.3.1.286	"Nicotinate and nicotinamide metabolism"
Medex_00016959-RA	10	Reactome: R-HSA-2024096;MetaCyc: PWY-6807;KEGG: 00511+3.2.1.23;KEGG: 00604+3.2.1.23;KEGG: 00052+3.2.1.23;KEGG: 00531+3.2.1.23;Reactome: R-HSA-6798695;Reactome: R-HSA-2160916;KEGG: 00600+3.2.1.23;Reactome: R-HSA-2206292	"HS-GAG degradation";"Xyloglucan degradation II (exoglucanase)";"Other glycan degradation";"Glycosphingolipid biosynthesis - ganglio series";"Galactose metabolism";"Glycosaminoglycan degradation";"Neutrophil degranulation";"Hyaluronan uptake and degradation";"Sphingolipid metabolism";"MPS VII - Sly syndrome"
Medex_00092010-RA	7	Reactome: R-HSA-418885;Reactome: R-HSA-373752;Reactome: R-HSA-418889;Reactome: R-HSA-418886;Reactome: R-HSA-376172;Reactome: R-HSA-418890;Reactome: R-HSA-428542	"DCC mediated attractive signaling";"Netrin-1 signaling";"Caspase activation via Dependence Receptors in the absence of ligand";"Netrin mediated repulsion signals";"DSCAM interactions";"Role of second messengers in netrin-1 signaling";"Regulation of commissural axon pathfinding by SLIT and ROBO"
Medex_00098892-RA	1	Reactome: R-HSA-1474228	"Degradation of the extracellular matrix"
Medex_00072335-RA	1	Reactome: R-HSA-6803157	"Antimicrobial peptides"
Medex_00005949-RA	1	Reactome: R-HSA-6802952	"Signaling by BRAF and RAF fusions"
Medex_00088434-RA	5	MetaCyc: PWY-5514;Reactome: R-HSA-70171;MetaCyc: PWY-6906;KEGG: 00520+3.5.99.6;MetaCyc: PWY-6855	"UDP-N-acetyl-D-galactosamine biosynthesis II";"Glycolysis";"Chitin derivatives degradation";"Amino sugar and nucleotide sugar metabolism";"Chitin degradation I (archaea)"
Medex_00037294-RA	2	Reactome: R-HSA-379716;Reactome: R-HSA-2408522	"Cytosolic tRNA aminoacylation";"Selenoamino acid metabolism"
Medex_00077821-RA	3	Reactome: R-HSA-5083627;Reactome: R-HSA-2022854;Reactome: R-HSA-5173105	"Defective LARGE causes MDDGA6 and MDDGB6";"Keratan sulfate biosynthesis";"O-linked glycosylation"
Medex_00102592-RA	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
Medex_00083704-RA	7	KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1	"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Human cytomegalovirus infection";"Relaxin signaling pathway";"Thermogenesis"
Medex_00047032-RA	1	Reactome: R-HSA-8949664	"Processing of SMDT1"
Medex_00036023-RA	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
Medex_00066938-RA	2	Reactome: R-HSA-9627069;Reactome: R-HSA-111458	"Regulation of the apoptosome activity";"Formation of apoptosome"
Medex_00026161-RA	3	MetaCyc: PWY-4361;MetaCyc: PWY-7174;KEGG: 00270+5.3.1.23	"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation II";"Cysteine and methionine metabolism"
Medex_00051156-RA	4	MetaCyc: PWY-2781;Reactome: R-HSA-6787450;KEGG: 00908+2.5.1.75;Reactome: R-HSA-6782315	"Cis-zeatin biosynthesis";"tRNA modification in the mitochondrion";"Zeatin biosynthesis";"tRNA modification in the nucleus and cytosol"
Medex_00029528-RA	3	KEGG: 00010+5.1.3.3;MetaCyc: PWY-6317;KEGG: 00052+5.1.3.3	"Glycolysis / Gluconeogenesis";"D-galactose degradation I (Leloir pathway)";"Galactose metabolism"
Medex_00074423-RA	6	Reactome: R-HSA-70221;MetaCyc: PWY-7238;MetaCyc: PWY-6731;MetaCyc: PWY-5941;KEGG: 00500+2.4.1.1;MetaCyc: PWY-6737	"Glycogen breakdown (glycogenolysis)";"Sucrose biosynthesis II";"Starch degradation III";"Glycogen degradation II";"Starch and sucrose metabolism";"Starch degradation V"
Medex_00004276-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00057191-RA	5	Reactome: R-HSA-8951664;Reactome: R-HSA-6781827;Reactome: R-HSA-6781823;Reactome: R-HSA-6782135;Reactome: R-HSA-6782210	"Neddylation";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Formation of TC-NER Pre-Incision Complex";"Dual incision in TC-NER";"Gap-filling DNA repair synthesis and ligation in TC-NER"
Medex_00013127-RA	2	MetaCyc: PWY-6981;KEGG: 00520+2.4.1.16	"Chitin biosynthesis";"Amino sugar and nucleotide sugar metabolism"
Medex_00099736-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Medex_00000423-RA	4	MetaCyc: PWY-6829;Reactome: R-HSA-6782861;MetaCyc: PWY-7286;MetaCyc: PWY-7285	"Trna methylation (yeast)";"Synthesis of wybutosine at G37 of tRNA(Phe)";"7-(3-amino-3-carboxypropyl)-wyosine biosynthesis";"Methylwyosine biosynthesis"
Medex_00005985-RA	6	MetaCyc: PWY-7039;Reactome: R-HSA-114508;KEGG: 00561+2.7.1.107;KEGG: 04070+2.7.1.107;MetaCyc: PWY-7817;KEGG: 00564+2.7.1.107	"Phosphatidate metabolism, as a signaling molecule";"Effects of PIP2 hydrolysis";"Glycerolipid metabolism";"Phosphatidylinositol signaling system";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Glycerophospholipid metabolism"
Medex_00053382-RA	2	Reactome: R-HSA-70350;Reactome: R-HSA-168928	"Fructose catabolism";"DDX58/IFIH1-mediated induction of interferon-alpha/beta"
Medex_00035153-RA	7	Reactome: R-HSA-76066;Reactome: R-HSA-749476;Reactome: R-HSA-73780;Reactome: R-HSA-1834949;Reactome: R-HSA-76061;Reactome: R-HSA-76071;Reactome: R-HSA-73980	"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Chain Elongation";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Transcription Termination"
Medex_00004970-RA	1	Reactome: R-HSA-430039	"mRNA decay by 5' to 3' exoribonuclease"
Medex_00036200-RA	1	Reactome: R-HSA-83936	"Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"
Medex_00025477-RA	6	KEGG: 00052+3.2.1.23;KEGG: 00531+3.2.1.23;KEGG: 00511+3.2.1.23;KEGG: 00600+3.2.1.23;MetaCyc: PWY-6807;KEGG: 00604+3.2.1.23	"Galactose metabolism";"Glycosaminoglycan degradation";"Other glycan degradation";"Sphingolipid metabolism";"Xyloglucan degradation II (exoglucanase)";"Glycosphingolipid biosynthesis - ganglio series"
Medex_00070911-RA	1	Reactome: R-HSA-1474228	"Degradation of the extracellular matrix"
Medex_00005261-RA	1	Reactome: R-HSA-9033241	"Peroxisomal protein import"
Medex_00000167-RA	66	Reactome: R-HSA-8951664;Reactome: R-HSA-2871837;Reactome: R-HSA-1169091;Reactome: R-HSA-174154;Reactome: R-HSA-9604323;Reactome: R-HSA-68827;Reactome: R-HSA-5678895;Reactome: R-HSA-69481;Reactome: R-HSA-350562;Reactome: R-HSA-174113;Reactome: R-HSA-8854050;Reactome: R-HSA-174084;Reactome: R-HSA-141430;Reactome: R-HSA-174048;Reactome: R-HSA-174178;Reactome: R-HSA-176412;Reactome: R-HSA-8853884;Reactome: R-HSA-5632684;Reactome: R-HSA-5689880;Reactome: R-HSA-5689603;Reactome: R-HSA-4608870;Reactome: R-HSA-176407;Reactome: R-HSA-75815;Reactome: R-HSA-195253;Reactome: R-HSA-9010553;Reactome: R-HSA-211733;Reactome: R-HSA-8939236;Reactome: R-HSA-68949;Reactome: R-HSA-180585;Reactome: R-HSA-9020702;Reactome: R-HSA-6798695;Reactome: R-HSA-5658442;Reactome: R-HSA-8941858;Reactome: R-HSA-983168;Reactome: R-HSA-202424;Reactome: R-HSA-174184;Reactome: R-HSA-5607764;Reactome: R-HSA-1234176;Reactome: R-HSA-69017;Reactome: R-HSA-69601;Reactome: R-HSA-5362768;Reactome: R-HSA-5676590;Reactome: R-HSA-8948751;Reactome: R-HSA-4641257;Reactome: R-HSA-5610783;Reactome: R-HSA-1236974;Reactome: R-HSA-179409;Reactome: R-HSA-2559582;Reactome: R-HSA-187577;Reactome: R-HSA-176408;Reactome: R-HSA-5607761;Reactome: R-HSA-5610780;Reactome: R-HSA-8852276;Reactome: R-HSA-1236978;Reactome: R-HSA-349425;Reactome: R-HSA-180534;Reactome: R-HSA-5610785;Reactome: R-HSA-5668541;Reactome: R-HSA-5687128;Reactome: R-HSA-8939902;Reactome: R-HSA-382556;Reactome: R-HSA-4641258;Reactome: R-HSA-2467813;Reactome: R-HSA-176409;Reactome: R-HSA-450408;Reactome: R-HSA-5358346	"Neddylation";"FCERI mediated NF-kB activation";"Activation of NF-kappaB in B cells";"APC/C:Cdc20 mediated degradation of Securin";"Negative regulation of NOTCH4 signaling";"CDT1 association with the CDC6:ORC:origin complex";"Defective CFTR causes cystic fibrosis";"G2/M Checkpoints";"Regulation of ornithine decarboxylase (ODC)";"SCF-beta-TrCP mediated degradation of Emi1";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Autodegradation of Cdh1 by Cdh1:APC/C";"Inactivation of APC/C via direct inhibition of the APC/C complex";"APC/C:Cdc20 mediated degradation of Cyclin B";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Phosphorylation of the APC/C";"Transcriptional Regulation by VENTX";"Hedgehog 'on' state";"Ub-specific processing proteases";"UCH proteinases";"Asymmetric localization of PCP proteins";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"Ubiquitin-dependent degradation of Cyclin D";"Degradation of beta-catenin by the destruction complex";"Regulation of expression of SLITs and ROBOs";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Orc1 removal from chromatin";"Vif-mediated degradation of APOBEC3G";"Interleukin-1 signaling";"Neutrophil degranulation";"Regulation of RAS by GAPs";"Regulation of RUNX3 expression and activity";"Antigen processing: Ubiquitination & Proteasome degradation";"Downstream TCR signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"CLEC7A (Dectin-1) signaling";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"CDK-mediated phosphorylation and removal of Cdc6";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"NIK-->noncanonical NF-kB signaling";"Regulation of PTEN stability and activity";"Degradation of AXIN";"Degradation of GLI2 by the proteasome";"ER-Phagosome pathway";"APC-Cdc20 mediated degradation of Nek2A";"Senescence-Associated Secretory Phenotype (SASP)";"SCF(Skp2)-mediated degradation of p27/p21";"Regulation of APC/C activators between G1/S and early anaphase";"Dectin-1 mediated noncanonical NF-kB signaling";"Degradation of GLI1 by the proteasome";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Cross-presentation of soluble exogenous antigens (endosomes)";"Autodegradation of the E3 ubiquitin ligase COP1";"Vpu mediated degradation of CD4";"GLI3 is processed to GLI3R by the proteasome";"TNFR2 non-canonical NF-kB pathway";"MAPK6/MAPK4 signaling";"Regulation of RUNX2 expression and activity";"ABC-family proteins mediated transport";"Degradation of DVL";"Separation of Sister Chromatids";"APC/C:Cdc20 mediated degradation of mitotic proteins";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Hedgehog ligand biogenesis"
Medex_00003249-RA	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
Medex_00035475-RA	2	Reactome: R-HSA-5610787;Reactome: R-HSA-5620924	"Hedgehog 'off' state";"Intraflagellar transport"
Medex_00006771-RA	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
Medex_00021031-RA	1	Reactome: R-HSA-611105	"Respiratory electron transport"
Medex_00059167-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00076930-RA	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
Medex_00042647-RA	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
Medex_00038849-RA	2	Reactome: R-HSA-390471;Reactome: R-HSA-1660662	"Association of TriC/CCT with target proteins during biosynthesis";"Glycosphingolipid metabolism"
Medex_00055924-RA	1	Reactome: R-HSA-2995383	"Initiation of Nuclear Envelope Reformation"
Medex_00069775-RA	2	Reactome: R-HSA-429947;Reactome: R-HSA-6804115	"Deadenylation of mRNA";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"
Medex_00063511-RA	1	Reactome: R-HSA-5658442	"Regulation of RAS by GAPs"
Medex_00028878-RA	4	Reactome: R-HSA-2644606;Reactome: R-HSA-2122947;Reactome: R-HSA-2894862;Reactome: R-HSA-350054	"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH1 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Notch-HLH transcription pathway"
Medex_00052557-RA	2	Reactome: R-HSA-71403;Reactome: R-HSA-611105	"Citric acid cycle (TCA cycle)";"Respiratory electron transport"
Medex_00093568-RA	5	Reactome: R-HSA-68949;Reactome: R-HSA-68867;Reactome: R-HSA-176974;Reactome: R-HSA-68962;Reactome: R-HSA-176187	"Orc1 removal from chromatin";"Assembly of the pre-replicative complex";"Unwinding of DNA";"Activation of the pre-replicative complex";"Activation of ATR in response to replication stress"
Medex_00041574-RA	24	Reactome: R-HSA-500657;Reactome: R-HSA-392170;Reactome: R-HSA-8964616;Reactome: R-HSA-418594;Reactome: R-HSA-416476;Reactome: R-HSA-418597;Reactome: R-HSA-456926;Reactome: R-HSA-416482;Reactome: R-HSA-381676;Reactome: R-HSA-8964315;Reactome: R-HSA-418217;Reactome: R-HSA-418555;Reactome: R-HSA-4086398;Reactome: R-HSA-163359;Reactome: R-HSA-400042;Reactome: R-HSA-392851;Reactome: R-HSA-432040;Reactome: R-HSA-202040;Reactome: R-HSA-392451;Reactome: R-HSA-418592;Reactome: R-HSA-428930;Reactome: R-HSA-420092;Reactome: R-HSA-6814122;Reactome: R-HSA-9009391	"Presynaptic function of Kainate receptors";"ADP signalling through P2Y purinoceptor 12";"G beta:gamma signalling through CDC42";"G alpha (i) signalling events";"G alpha (q) signalling events";"G alpha (z) signalling events";"Thrombin signalling through proteinase activated receptors (PARs)";"G alpha (12/13) signalling events";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"G beta:gamma signalling through BTK";"G beta:gamma signalling through PLC beta";"G alpha (s) signalling events";"Ca2+ pathway";"Glucagon signaling in metabolic regulation";"Adrenaline,noradrenaline inhibits insulin secretion";"Prostacyclin signalling through prostacyclin receptor";"Vasopressin regulates renal water homeostasis via Aquaporins";"G-protein activation";"G beta:gamma signalling through PI3Kgamma";"ADP signalling through P2Y purinoceptor 1";"Thromboxane signalling through TP receptor";"Glucagon-type ligand receptors";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"Extra-nuclear estrogen signaling"
Medex_00053792-RA	1	Reactome: R-HSA-432047	"Passive transport by Aquaporins"
Medex_00032102-RA	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5419276;Reactome: R-HSA-5368286	"Mitochondrial translation elongation";"Mitochondrial translation termination";"Mitochondrial translation initiation"
Medex_00021271-RA	3	Reactome: R-HSA-159236;Reactome: R-HSA-73856;Reactome: R-HSA-72187	"Transport of Mature mRNA derived from an Intron-Containing Transcript";"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing"
Medex_00021015-RA	1	Reactome: R-HSA-6798163	"Choline catabolism"
Medex_00024514-RA	2	MetaCyc: PWY-5697;KEGG: 00230+3.5.3.4	"Allantoin degradation to ureidoglycolate I (urea producing)";"Purine metabolism"
Medex_00045045-RA	1	Reactome: R-HSA-6798163	"Choline catabolism"
Medex_00006703-RA	1	Reactome: R-HSA-912446	"Meiotic recombination"
Medex_00017123-RA	27	Reactome: R-HSA-6784531;Reactome: R-HSA-3108214;Reactome: R-HSA-191859;Reactome: R-HSA-159236;Reactome: R-HSA-168325;Reactome: R-HSA-9610379;Reactome: R-HSA-5619107;Reactome: R-HSA-9609690;Reactome: R-HSA-4551638;Reactome: R-HSA-4085377;Reactome: R-HSA-4570464;Reactome: R-HSA-170822;Reactome: R-HSA-168271;Reactome: R-HSA-180910;Reactome: R-HSA-3301854;Reactome: R-HSA-3232142;Reactome: R-HSA-168276;Reactome: R-HSA-5578749;Reactome: R-HSA-159230;Reactome: R-HSA-4615885;Reactome: R-HSA-3371453;Reactome: R-HSA-159231;Reactome: R-HSA-159227;Reactome: R-HSA-180746;Reactome: R-HSA-168333;Reactome: R-HSA-1169408;Reactome: R-HSA-165054	"tRNA processing in the nucleus";"SUMOylation of DNA damage response and repair proteins";"snRNP Assembly";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Viral Messenger RNA Synthesis";"HCMV Late Events";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"HCMV Early Events";"SUMOylation of chromatin organization proteins";"SUMOylation of SUMOylation proteins";"SUMOylation of RNA binding proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Transport of Ribonucleoproteins into the Host Nucleus";"Vpr-mediated nuclear import of PICs";"Nuclear Pore Complex (NPC) Disassembly";"SUMOylation of ubiquitinylation proteins";"NS1 Mediated Effects on Host Pathways";"Transcriptional regulation by small RNAs";"Transport of the SLBP Dependant Mature mRNA";"SUMOylation of DNA replication proteins";"Regulation of HSF1-mediated heat shock response";"Transport of Mature mRNA Derived from an Intronless Transcript";"Transport of the SLBP independent Mature mRNA";"Nuclear import of Rev protein";"NEP/NS2 Interacts with the Cellular Export Machinery";"ISG15 antiviral mechanism";"Rev-mediated nuclear export of HIV RNA"
Medex_00052649-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00008662-RA	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
Medex_00000710-RA	1	Reactome: R-HSA-209968	"Thyroxine biosynthesis"
Medex_00031627-RA	4	MetaCyc: PWY-7219;Reactome: R-HSA-499943;KEGG: 00730+2.7.4.3;KEGG: 00230+2.7.4.3	"Adenosine ribonucleotides de novo biosynthesis";"Interconversion of nucleotide di- and triphosphates";"Thiamine metabolism";"Purine metabolism"
Medex_00020518-RA	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
Medex_00049788-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00068938-RA	7	Reactome: R-HSA-76071;Reactome: R-HSA-73980;Reactome: R-HSA-1834949;Reactome: R-HSA-76061;Reactome: R-HSA-76066;Reactome: R-HSA-749476;Reactome: R-HSA-73780	"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Transcription Termination";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Chain Elongation"
Medex_00076883-RA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
Medex_00016720-RA	2	Reactome: R-HSA-5628897;Reactome: R-HSA-611105	"TP53 Regulates Metabolic Genes";"Respiratory electron transport"
Medex_00005313-RA	3	Reactome: R-HSA-1989781;Reactome: R-HSA-9018519;Reactome: R-HSA-381340	"PPARA activates gene expression";"Estrogen-dependent gene expression";"Transcriptional regulation of white adipocyte differentiation"
Medex_00046773-RA	1	Reactome: R-HSA-400253	"Circadian Clock"
Medex_00048882-RA	4	Reactome: R-HSA-5578775;Reactome: R-HSA-936837;Reactome: R-HSA-418359;Reactome: R-HSA-1912420	"Ion homeostasis";"Ion transport by P-type ATPases";"Reduction of cytosolic Ca++ levels";"Pre-NOTCH Processing in Golgi"
Medex_00029448-RA	1	Reactome: R-HSA-373080	"Class B/2 (Secretin family receptors)"
Medex_00009375-RA	2	Reactome: R-HSA-5576893;Reactome: R-HSA-5576892	"Phase 2 - plateau phase";"Phase 0 - rapid depolarisation"
Medex_00003149-RA	2	KEGG: 00970+2.1.2.9;KEGG: 00670+2.1.2.9	"Aminoacyl-tRNA biosynthesis";"One carbon pool by folate"
Medex_00059876-RA	3	KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16	"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway"
Medex_00051738-RA	4	Reactome: R-HSA-6811440;Reactome: R-HSA-8856825;Reactome: R-HSA-8856828;Reactome: R-HSA-432720	"Retrograde transport at the Trans-Golgi-Network";"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis";"Lysosome Vesicle Biogenesis"
Medex_00045267-RA	1	Reactome: R-HSA-400253	"Circadian Clock"
Medex_00047767-RA	2	Reactome: R-HSA-174403;Reactome: R-HSA-5578999	"Glutathione synthesis and recycling";"Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD)"
Medex_00081807-RA	1	Reactome: R-HSA-2132295	"MHC class II antigen presentation"
Medex_00073959-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00014481-RA	4	KEGG: 00330+4.1.1.50;KEGG: 00270+4.1.1.50;MetaCyc: PWY-6834;Reactome: R-HSA-351202	"Arginine and proline metabolism";"Cysteine and methionine metabolism";"Spermidine biosynthesis III";"Metabolism of polyamines"
Medex_00040074-RA	4	Reactome: R-HSA-3000171;Reactome: R-HSA-3000178;Reactome: R-HSA-3000157;Reactome: R-HSA-8874081	"Non-integrin membrane-ECM interactions";"ECM proteoglycans";"Laminin interactions";"MET activates PTK2 signaling"
Medex_00074263-RA	2	KEGG: 00030+2.7.6.1;KEGG: 00230+2.7.6.1	"Pentose phosphate pathway";"Purine metabolism"
Medex_00053321-RA	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
Medex_00074319-RA	1	Reactome: R-HSA-432047	"Passive transport by Aquaporins"
Medex_00073677-RA	1	Reactome: R-HSA-606279	"Deposition of new CENPA-containing nucleosomes at the centromere"
Medex_00022370-RA	2	Reactome: R-HSA-5610787;Reactome: R-HSA-5620924	"Hedgehog 'off' state";"Intraflagellar transport"
Medex_00045092-RA	16	Reactome: R-HSA-975957;Reactome: R-HSA-1799339;Reactome: R-HSA-9633012;Reactome: R-HSA-72706;Reactome: R-HSA-975956;Reactome: R-HSA-72764;Reactome: R-HSA-72702;Reactome: R-HSA-6791226;Reactome: R-HSA-192823;Reactome: R-HSA-72649;Reactome: R-HSA-72695;Reactome: R-HSA-156902;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-72689;Reactome: R-HSA-2408557	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Ribosomal scanning and start codon recognition";"Major pathway of rRNA processing in the nucleolus and cytosol";"Viral mRNA Translation";"Translation initiation complex formation";"Formation of the ternary complex, and subsequently, the 43S complex";"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Formation of a pool of free 40S subunits";"Selenocysteine synthesis"
Medex_00008212-RA	1	MetaCyc: PWY-7799	"Arg/N-end rule pathway (eukaryotic)"
Medex_00036678-RA	1	Reactome: R-HSA-6790901	"rRNA modification in the nucleus and cytosol"
Medex_00077931-RA	3	Reactome: R-HSA-6811438;Reactome: R-HSA-6811440;Reactome: R-HSA-6807878	"Intra-Golgi traffic";"Retrograde transport at the Trans-Golgi-Network";"COPI-mediated anterograde transport"
Medex_00046114-RA	6	Reactome: R-HSA-5684045;Reactome: R-HSA-390247;Reactome: R-HSA-2046106;Reactome: R-HSA-9603798;Reactome: R-HSA-1369062;Reactome: R-HSA-2046105	"Defective ABCD1 causes adrenoleukodystrophy (ALD)";"Beta-oxidation of very long chain fatty acids";"alpha-linolenic acid (ALA) metabolism";"Class I peroxisomal membrane protein import";"ABC transporters in lipid homeostasis";"Linoleic acid (LA) metabolism"
Medex_00094086-RA	3	Reactome: R-HSA-418457;Reactome: R-HSA-4086398;Reactome: R-HSA-392517	"cGMP effects";"Ca2+ pathway";"Rap1 signalling"
Medex_00019339-RA	1	KEGG: 00970+6.1.1.9	"Aminoacyl-tRNA biosynthesis"
Medex_00003854-RA	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
Medex_00062303-RA	4	Reactome: R-HSA-917977;Reactome: R-HSA-1222556;Reactome: R-HSA-983712;Reactome: R-HSA-77387	"Transferrin endocytosis and recycling";"ROS and RNS production in phagocytes";"Ion channel transport";"Insulin receptor recycling"
Medex_00039268-RA	2	Reactome: R-HSA-983168;Reactome: R-HSA-8951664	"Antigen processing: Ubiquitination & Proteasome degradation";"Neddylation"
Medex_00090755-RA	1	KEGG: 00970+6.1.1.19	"Aminoacyl-tRNA biosynthesis"
Medex_00091332-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Medex_00014338-RA	2	Reactome: R-HSA-1660662;Reactome: R-HSA-390471	"Glycosphingolipid metabolism";"Association of TriC/CCT with target proteins during biosynthesis"
Medex_00048511-RA	1	Reactome: R-HSA-209968	"Thyroxine biosynthesis"
Medex_00071192-RA	1	KEGG: 00480+3.4.11.2	"Glutathione metabolism"
Medex_00057410-RA	7	MetaCyc: PWY-6351;Reactome: R-HSA-1660499;Reactome: R-HSA-1660516;KEGG: 04070+2.7.1.67;KEGG: 00562+2.7.1.67;Reactome: R-HSA-1660514;MetaCyc: PWY-6352	"D-myo-inositol (1,4,5)-trisphosphate biosynthesis";"Synthesis of PIPs at the plasma membrane";"Synthesis of PIPs at the early endosome membrane";"Phosphatidylinositol signaling system";"Inositol phosphate metabolism";"Synthesis of PIPs at the Golgi membrane";"3-phosphoinositide biosynthesis"
Medex_00024307-RA	3	Reactome: R-HSA-2559580;Reactome: R-HSA-8943724;Reactome: R-HSA-8939243	"Oxidative Stress Induced Senescence";"Regulation of PTEN gene transcription";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"
Medex_00085535-RA	1	Reactome: R-HSA-381753	"Olfactory Signaling Pathway"
Medex_00022472-RA	2	Reactome: R-HSA-180024;KEGG: 00230+3.1.4.53	"DARPP-32 events";"Purine metabolism"
Medex_00004107-RA	3	Reactome: R-HSA-5663213;Reactome: R-HSA-2029482;Reactome: R-HSA-4420097	"RHO GTPases Activate WASPs and WAVEs";"Regulation of actin dynamics for phagocytic cup formation";"VEGFA-VEGFR2 Pathway"
Medex_00047294-RA	3	Reactome: R-HSA-6798695;KEGG: 00511+3.2.1.51;MetaCyc: PWY-6807	"Neutrophil degranulation";"Other glycan degradation";"Xyloglucan degradation II (exoglucanase)"
Medex_00028569-RA	2	Reactome: R-HSA-8949613;Reactome: R-HSA-163210	"Cristae formation";"Formation of ATP by chemiosmotic coupling"
Medex_00054187-RA	2	Reactome: R-HSA-390522;Reactome: R-HSA-445355	"Striated Muscle Contraction";"Smooth Muscle Contraction"
Medex_00022036-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Medex_00060354-RA	5	Reactome: R-HSA-430039;Reactome: R-HSA-380994;Reactome: R-HSA-450513;Reactome: R-HSA-450604;Reactome: R-HSA-450385	"mRNA decay by 5' to 3' exoribonuclease";"ATF4 activates genes in response to endoplasmic reticulum stress";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"KSRP (KHSRP) binds and destabilizes mRNA";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA"
Medex_00021477-RA	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276	"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination"
Medex_00008718-RA	1	KEGG: 00480+3.4.11.2	"Glutathione metabolism"
Medex_00085642-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Medex_00026559-RA	2	Reactome: R-HSA-390522;Reactome: R-HSA-445355	"Striated Muscle Contraction";"Smooth Muscle Contraction"
Medex_00006786-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00015484-RA	14	Reactome: R-HSA-5620912;Reactome: R-HSA-5663220;Reactome: R-HSA-2565942;Reactome: R-HSA-380320;Reactome: R-HSA-2500257;Reactome: R-HSA-8854518;Reactome: R-HSA-141444;Reactome: R-HSA-2467813;Reactome: R-HSA-380284;Reactome: R-HSA-380259;Reactome: R-HSA-380270;Reactome: R-HSA-8852276;Reactome: R-HSA-9648025;Reactome: R-HSA-68877	"Anchoring of the basal body to the plasma membrane";"RHO GTPases Activate Formins";"Regulation of PLK1 Activity at G2/M Transition";"Recruitment of NuMA to mitotic centrosomes";"Resolution of Sister Chromatid Cohesion";"AURKA Activation by TPX2";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Separation of Sister Chromatids";"Loss of proteins required for interphase microtubule organization from the centrosome";"Loss of Nlp from mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes";"The role of GTSE1 in G2/M progression after G2 checkpoint";"EML4 and NUDC in mitotic spindle formation";"Mitotic Prometaphase"
Medex_00077313-RA	2	Reactome: R-HSA-430039;Reactome: R-HSA-72163	"mRNA decay by 5' to 3' exoribonuclease";"mRNA Splicing - Major Pathway"
Medex_00006241-RA	1	Reactome: R-HSA-5656169	"Termination of translesion DNA synthesis"
Medex_00035857-RA	6	Reactome: R-HSA-72649;Reactome: R-HSA-72702;Reactome: R-HSA-72695;Reactome: R-HSA-156827;Reactome: R-HSA-72706;Reactome: R-HSA-72689	"Translation initiation complex formation";"Ribosomal scanning and start codon recognition";"Formation of the ternary complex, and subsequently, the 43S complex";"L13a-mediated translational silencing of Ceruloplasmin expression";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Formation of a pool of free 40S subunits"
Medex_00021352-RA	5	MetaCyc: PWY-6368;Reactome: R-HSA-1660499;Reactome: R-HSA-8856828;KEGG: 04070+3.1.3.36;KEGG: 00562+3.1.3.36	"3-phosphoinositide degradation";"Synthesis of PIPs at the plasma membrane";"Clathrin-mediated endocytosis";"Phosphatidylinositol signaling system";"Inositol phosphate metabolism"
Medex_00006907-RA	5	Reactome: R-HSA-6811434;Reactome: R-HSA-6811438;Reactome: R-HSA-204005;Reactome: R-HSA-6807878;Reactome: R-HSA-6811440	"COPI-dependent Golgi-to-ER retrograde traffic";"Intra-Golgi traffic";"COPII-mediated vesicle transport";"COPI-mediated anterograde transport";"Retrograde transport at the Trans-Golgi-Network"
Medex_00079809-RA	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
Medex_00008716-RA	1	KEGG: 00480+3.4.11.2	"Glutathione metabolism"
Medex_00004860-RA	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
Medex_00058867-RA	1	Reactome: R-HSA-211981	"Xenobiotics"
Medex_00029218-RA	6	Reactome: R-HSA-6791226;Reactome: R-HSA-450604;Reactome: R-HSA-450513;Reactome: R-HSA-450385;Reactome: R-HSA-380994;Reactome: R-HSA-429958	"Major pathway of rRNA processing in the nucleolus and cytosol";"KSRP (KHSRP) binds and destabilizes mRNA";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"ATF4 activates genes in response to endoplasmic reticulum stress";"mRNA decay by 3' to 5' exoribonuclease"
Medex_00052447-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Medex_00032347-RA	4	Reactome: R-HSA-8856825;Reactome: R-HSA-6781823;Reactome: R-HSA-5696394;Reactome: R-HSA-8951664	"Cargo recognition for clathrin-mediated endocytosis";"Formation of TC-NER Pre-Incision Complex";"DNA Damage Recognition in GG-NER";"Neddylation"
Medex_00078947-RA	2	Reactome: R-HSA-390471;Reactome: R-HSA-1660662	"Association of TriC/CCT with target proteins during biosynthesis";"Glycosphingolipid metabolism"
Medex_00056014-RA	1	Reactome: R-HSA-1483101	"Synthesis of PS"
Medex_00031502-RA	5	KEGG: 00520+2.6.1.16;Reactome: R-HSA-446210;KEGG: 00250+2.6.1.16;MetaCyc: PWY-8013;MetaCyc: PWY-6749	"Amino sugar and nucleotide sugar metabolism";"Synthesis of UDP-N-acetyl-glucosamine";"Alanine, aspartate and glutamate metabolism";"UDP-N-acetyl-D-galactosamine biosynthesis III";"CMP-legionaminate biosynthesis I"
Medex_00045006-RA	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
Medex_00074742-RA	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
Medex_00081786-RA	4	Reactome: R-HSA-6811434;Reactome: R-HSA-2132295;Reactome: R-HSA-5625970;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"MHC class II antigen presentation";"RHO GTPases activate KTN1";"Kinesins"
Medex_00073912-RA	2	Reactome: R-HSA-8876198;Reactome: R-HSA-6811436	"RAB GEFs exchange GTP for GDP on RABs";"COPI-independent Golgi-to-ER retrograde traffic"
Medex_00074502-RA	2	Reactome: R-HSA-5628897;Reactome: R-HSA-611105	"TP53 Regulates Metabolic Genes";"Respiratory electron transport"
Medex_00021732-RA	3	KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16	"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation"
Medex_00025415-RA	3	MetaCyc: PWY-6596;Reactome: R-HSA-74217;KEGG: 00230+3.5.4.6	"Adenosine nucleotides degradation I";"Purine salvage";"Purine metabolism"
Medex_00024594-RA	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
Medex_00055368-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00030672-RA	2	Reactome: R-HSA-72163;Reactome: R-HSA-72165	"mRNA Splicing - Major Pathway";"mRNA Splicing - Minor Pathway"
Medex_00051997-RA	13	KEGG: 00603+3.2.1.52;MetaCyc: PWY-6902;MetaCyc: PWY-7883;Reactome: R-HSA-2160916;KEGG: 00531+3.2.1.52;KEGG: 00520+3.2.1.52;MetaCyc: PWY-7822;KEGG: 00513+3.2.1.52;KEGG: 00511+3.2.1.52;Reactome: R-HSA-2022857;Reactome: R-HSA-1660662;KEGG: 00604+3.2.1.52;Reactome: R-HSA-2024101	"Glycosphingolipid biosynthesis - globo and isoglobo series";"Chitin degradation II (Vibrio)";"Anhydromuropeptides recycling II";"Hyaluronan uptake and degradation";"Glycosaminoglycan degradation";"Amino sugar and nucleotide sugar metabolism";"Chitin degradation III (Serratia)";"Various types of N-glycan biosynthesis";"Other glycan degradation";"Keratan sulfate degradation";"Glycosphingolipid metabolism";"Glycosphingolipid biosynthesis - ganglio series";"CS/DS degradation"
Medex_00034318-RA	5	MetaCyc: PWY-5981;MetaCyc: PWY-7902;KEGG: 00564+1.1.1.94;Reactome: R-HSA-1483166;MetaCyc: PWY-5667	"CDP-diacylglycerol biosynthesis III";"Glucosylglycerol biosynthesis";"Glycerophospholipid metabolism";"Synthesis of PA";"CDP-diacylglycerol biosynthesis I"
Medex_00034714-RA	2	Reactome: R-HSA-6811434;Reactome: R-HSA-6807878	"COPI-dependent Golgi-to-ER retrograde traffic";"COPI-mediated anterograde transport"
Medex_00055737-RA	2	Reactome: R-HSA-71403;Reactome: R-HSA-611105	"Citric acid cycle (TCA cycle)";"Respiratory electron transport"
Medex_00007406-RA	4	Reactome: R-HSA-917977;Reactome: R-HSA-1222556;Reactome: R-HSA-77387;Reactome: R-HSA-983712	"Transferrin endocytosis and recycling";"ROS and RNS production in phagocytes";"Insulin receptor recycling";"Ion channel transport"
Medex_00021567-RA	5	Reactome: R-HSA-983170;Reactome: R-HSA-5694530;Reactome: R-HSA-1655829;Reactome: R-HSA-204005;Reactome: R-HSA-2132295	"Antigen Presentation: Folding, assembly and peptide loading of class I MHC";"Cargo concentration in the ER";"Regulation of cholesterol biosynthesis by SREBP (SREBF)";"COPII-mediated vesicle transport";"MHC class II antigen presentation"
Medex_00009117-RA	1	Reactome: R-HSA-6784531	"tRNA processing in the nucleus"
Medex_00012453-RA	1	Reactome: R-HSA-73817	"Purine ribonucleoside monophosphate biosynthesis"
Medex_00052435-RA	2	Reactome: R-HSA-6804115;Reactome: R-HSA-429947	"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Deadenylation of mRNA"
Medex_00007438-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Medex_00057528-RA	1	Reactome: R-HSA-2514853	"Condensation of Prometaphase Chromosomes"
Medex_00048663-RA	1	KEGG: 00970+6.3.5.7	"Aminoacyl-tRNA biosynthesis"
Medex_00022640-RA	8	Reactome: R-HSA-68867;Reactome: R-HSA-68949;Reactome: R-HSA-68616;Reactome: R-HSA-68827;Reactome: R-HSA-113507;Reactome: R-HSA-68962;Reactome: R-HSA-176187;Reactome: R-HSA-68689	"Assembly of the pre-replicative complex";"Orc1 removal from chromatin";"Assembly of the ORC complex at the origin of replication";"CDT1 association with the CDC6:ORC:origin complex";"E2F-enabled inhibition of pre-replication complex formation";"Activation of the pre-replicative complex";"Activation of ATR in response to replication stress";"CDC6 association with the ORC:origin complex"
Medex_00081888-RA	1	Reactome: R-HSA-191859	"snRNP Assembly"
Medex_00017813-RA	1	Reactome: R-HSA-8856828	"Clathrin-mediated endocytosis"
Medex_00049508-RA	24	Reactome: R-HSA-5617833;Reactome: R-HSA-9646399;Reactome: R-HSA-2467813;Reactome: R-HSA-68877;Reactome: R-HSA-6811434;Reactome: R-HSA-9648025;Reactome: R-HSA-1445148;Reactome: R-HSA-5663220;Reactome: R-HSA-3371497;Reactome: R-HSA-2500257;Reactome: R-HSA-380320;Reactome: R-HSA-9609736;Reactome: R-HSA-983189;Reactome: R-HSA-8852276;Reactome: R-HSA-6811436;Reactome: R-HSA-9609690;Reactome: R-HSA-8955332;Reactome: R-HSA-437239;Reactome: R-HSA-6807878;Reactome: R-HSA-190840;Reactome: R-HSA-9619483;Reactome: R-HSA-190861;Reactome: R-HSA-2132295;Reactome: R-HSA-5626467	"Cilium Assembly";"Aggrephagy";"Separation of Sister Chromatids";"Mitotic Prometaphase";"COPI-dependent Golgi-to-ER retrograde traffic";"EML4 and NUDC in mitotic spindle formation";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"RHO GTPases Activate Formins";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Resolution of Sister Chromatid Cohesion";"Recruitment of NuMA to mitotic centrosomes";"Assembly and cell surface presentation of NMDA receptors";"Kinesins";"The role of GTSE1 in G2/M progression after G2 checkpoint";"COPI-independent Golgi-to-ER retrograde traffic";"HCMV Early Events";"Carboxyterminal post-translational modifications of tubulin";"Recycling pathway of L1";"COPI-mediated anterograde transport";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Activation of AMPK downstream of NMDARs";"Gap junction assembly";"MHC class II antigen presentation";"RHO GTPases activate IQGAPs"
Medex_00089890-RA	2	Reactome: R-HSA-909733;Reactome: R-HSA-8983711	"Interferon alpha/beta signaling";"OAS antiviral response"
Medex_00081437-RA	1	Reactome: R-HSA-6787450	"tRNA modification in the mitochondrion"
Medex_00046355-RA	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
Medex_00090718-RA	2	Reactome: R-HSA-5576892;Reactome: R-HSA-445095	"Phase 0 - rapid depolarisation";"Interaction between L1 and Ankyrins"
Medex_00000165-RA	16	Reactome: R-HSA-2559582;Reactome: R-HSA-174084;Reactome: R-HSA-141430;Reactome: R-HSA-983168;Reactome: R-HSA-176408;Reactome: R-HSA-174048;Reactome: R-HSA-176409;Reactome: R-HSA-2467813;Reactome: R-HSA-179409;Reactome: R-HSA-69017;Reactome: R-HSA-176407;Reactome: R-HSA-174178;Reactome: R-HSA-176412;Reactome: R-HSA-8853884;Reactome: R-HSA-174154;Reactome: R-HSA-174184	"Senescence-Associated Secretory Phenotype (SASP)";"Autodegradation of Cdh1 by Cdh1:APC/C";"Inactivation of APC/C via direct inhibition of the APC/C complex";"Antigen processing: Ubiquitination & Proteasome degradation";"Regulation of APC/C activators between G1/S and early anaphase";"APC/C:Cdc20 mediated degradation of Cyclin B";"APC/C:Cdc20 mediated degradation of mitotic proteins";"Separation of Sister Chromatids";"APC-Cdc20 mediated degradation of Nek2A";"CDK-mediated phosphorylation and removal of Cdc6";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Phosphorylation of the APC/C";"Transcriptional Regulation by VENTX";"APC/C:Cdc20 mediated degradation of Securin";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A"
Medex_00002819-RA	1	Reactome: R-HSA-382556	"ABC-family proteins mediated transport"
Medex_00078756-RA	4	Reactome: R-HSA-8856825;Reactome: R-HSA-6781823;Reactome: R-HSA-5696394;Reactome: R-HSA-8951664	"Cargo recognition for clathrin-mediated endocytosis";"Formation of TC-NER Pre-Incision Complex";"DNA Damage Recognition in GG-NER";"Neddylation"
Medex_00065989-RA	17	Reactome: R-HSA-9020702;Reactome: R-HSA-202424;Reactome: R-HSA-937072;Reactome: R-HSA-5357956;Reactome: R-HSA-168638;Reactome: R-HSA-5689880;Reactome: R-HSA-450321;Reactome: R-HSA-9645460;Reactome: R-HSA-9014325;Reactome: R-HSA-445989;Reactome: R-HSA-2871837;Reactome: R-HSA-450302;Reactome: R-HSA-4086398;Reactome: R-HSA-5607764;Reactome: R-HSA-937042;Reactome: R-HSA-1169091;Reactome: R-HSA-975163	"Interleukin-1 signaling";"Downstream TCR signaling";"TRAF6-mediated induction of TAK1 complex within TLR4 complex";"TNFR1-induced NFkappaB signaling pathway";"NOD1/2 Signaling Pathway";"Ub-specific processing proteases";"JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1";"Alpha-protein kinase 1 signaling pathway";"TICAM1,TRAF6-dependent induction of TAK1 complex";"TAK1 activates NFkB by phosphorylation and activation of IKKs complex";"FCERI mediated NF-kB activation";"activated TAK1 mediates p38 MAPK activation";"Ca2+ pathway";"CLEC7A (Dectin-1) signaling";"IRAK2 mediated activation of TAK1 complex";"Activation of NF-kappaB in B cells";"IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation"
Medex_00067909-RA	7	Reactome: R-HSA-380972;Reactome: R-HSA-5628897;Reactome: R-HSA-9639288;Reactome: R-HSA-165159;Reactome: R-HSA-1632852;Reactome: R-HSA-166208;Reactome: R-HSA-8943724	"Energy dependent regulation of mTOR by LKB1-AMPK";"TP53 Regulates Metabolic Genes";"Amino acids regulate mTORC1";"mTOR signalling";"Macroautophagy";"mTORC1-mediated signalling";"Regulation of PTEN gene transcription"
Medex_00051992-RA	1	KEGG: 00970+6.1.1.7	"Aminoacyl-tRNA biosynthesis"
Medex_00076260-RA	3	Reactome: R-HSA-6798695;Reactome: R-HSA-9609523;Reactome: R-HSA-1660661	"Neutrophil degranulation";"Insertion of tail-anchored proteins into the endoplasmic reticulum membrane";"Sphingolipid de novo biosynthesis"
Medex_00001708-RA	3	KEGG: 00740+3.1.3.2;KEGG: 00730+3.1.3.2;MetaCyc: PWY-6348	"Riboflavin metabolism";"Thiamine metabolism";"Phosphate acquisition"
Medex_00061080-RA	6	Reactome: R-HSA-9640463;MetaCyc: PWY-5884;KEGG: 00073+1.2.1.84;MetaCyc: PWY-7782;MetaCyc: PWY-7656;MetaCyc: PWY-6733	"Wax biosynthesis";"Wax esters biosynthesis I";"Cutin, suberine and wax biosynthesis";"Plasmalogen biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Sporopollenin precursors biosynthesis"
Medex_00064350-RA	1	Reactome: R-HSA-1632852	"Macroautophagy"
Medex_00022759-RA	1	Reactome: R-HSA-5610787	"Hedgehog 'off' state"
Medex_00090370-RA	3	KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16	"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
Medex_00025461-RA	6	Reactome: R-HSA-176187;Reactome: R-HSA-176974;Reactome: R-HSA-68962;Reactome: R-HSA-68949;Reactome: R-HSA-68867;Reactome: R-HSA-69052	"Activation of ATR in response to replication stress";"Unwinding of DNA";"Activation of the pre-replicative complex";"Orc1 removal from chromatin";"Assembly of the pre-replicative complex";"Switching of origins to a post-replicative state"
Medex_00077049-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Medex_00039552-RA	24	Reactome: R-HSA-416482;Reactome: R-HSA-381676;Reactome: R-HSA-8964315;Reactome: R-HSA-418217;Reactome: R-HSA-163359;Reactome: R-HSA-4086398;Reactome: R-HSA-418555;Reactome: R-HSA-8964616;Reactome: R-HSA-392170;Reactome: R-HSA-500657;Reactome: R-HSA-418594;Reactome: R-HSA-416476;Reactome: R-HSA-456926;Reactome: R-HSA-418597;Reactome: R-HSA-420092;Reactome: R-HSA-428930;Reactome: R-HSA-418592;Reactome: R-HSA-6814122;Reactome: R-HSA-9009391;Reactome: R-HSA-392851;Reactome: R-HSA-400042;Reactome: R-HSA-392451;Reactome: R-HSA-432040;Reactome: R-HSA-202040	"G alpha (12/13) signalling events";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"G beta:gamma signalling through BTK";"G beta:gamma signalling through PLC beta";"Glucagon signaling in metabolic regulation";"Ca2+ pathway";"G alpha (s) signalling events";"G beta:gamma signalling through CDC42";"ADP signalling through P2Y purinoceptor 12";"Presynaptic function of Kainate receptors";"G alpha (i) signalling events";"G alpha (q) signalling events";"Thrombin signalling through proteinase activated receptors (PARs)";"G alpha (z) signalling events";"Glucagon-type ligand receptors";"Thromboxane signalling through TP receptor";"ADP signalling through P2Y purinoceptor 1";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"Extra-nuclear estrogen signaling";"Prostacyclin signalling through prostacyclin receptor";"Adrenaline,noradrenaline inhibits insulin secretion";"G beta:gamma signalling through PI3Kgamma";"Vasopressin regulates renal water homeostasis via Aquaporins";"G-protein activation"
Medex_00033216-RA	1	Reactome: R-HSA-4085001	"Sialic acid metabolism"
Medex_00039535-RA	6	MetaCyc: PWY-4261;KEGG: 00564+1.1.5.3;MetaCyc: PWY-6952;Reactome: R-HSA-163560;Reactome: R-HSA-1483166;MetaCyc: PWY-6118	"Glycerol degradation I";"Glycerophospholipid metabolism";"Glycerophosphodiester degradation";"Triglyceride catabolism";"Synthesis of PA";"Glycerol-3-phosphate shuttle"
Medex_00033342-RA	1	Reactome: R-HSA-427975	"Proton/oligopeptide cotransporters"
Medex_00017418-RA	1	Reactome: R-HSA-611105	"Respiratory electron transport"
Medex_00047551-RA	11	Reactome: R-HSA-73779;Reactome: R-HSA-76042;Reactome: R-HSA-167162;Reactome: R-HSA-3214847;Reactome: R-HSA-5689880;Reactome: R-HSA-6804756;Reactome: R-HSA-167172;Reactome: R-HSA-75953;Reactome: R-HSA-167161;Reactome: R-HSA-73776;Reactome: R-HSA-674695	"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II HIV Promoter Escape";"HATs acetylate histones";"Ub-specific processing proteases";"Regulation of TP53 Activity through Phosphorylation";"Transcription of the HIV genome";"RNA Polymerase II Transcription Initiation";"HIV Transcription Initiation";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Pre-transcription Events"
Medex_00051505-RA	4	Reactome: R-HSA-2132295;Reactome: R-HSA-3371497;Reactome: R-HSA-6807878;Reactome: R-HSA-6811436	"MHC class II antigen presentation";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-mediated anterograde transport";"COPI-independent Golgi-to-ER retrograde traffic"
Medex_00042648-RA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Medex_00064182-RA	7	MetaCyc: PWY-5484;KEGG: 00030+3.1.3.11;KEGG: 00710+3.1.3.11;KEGG: 00680+3.1.3.11;KEGG: 00051+3.1.3.11;KEGG: 00010+3.1.3.11;Reactome: R-HSA-70263	"Glycolysis II (from fructose 6-phosphate)";"Pentose phosphate pathway";"Carbon fixation in photosynthetic organisms";"Methane metabolism";"Fructose and mannose metabolism";"Glycolysis / Gluconeogenesis";"Gluconeogenesis"
Medex_00014178-RA	1	Reactome: R-HSA-880009	"Interconversion of 2-oxoglutarate and 2-hydroxyglutarate"
Medex_00059111-RA	1	Reactome: R-HSA-352230	"Amino acid transport across the plasma membrane"
Medex_00000077-RA	1	KEGG: 00480+3.4.11.2	"Glutathione metabolism"
Medex_00059971-RA	12	Reactome: R-HSA-5620912;Reactome: R-HSA-6811436;Reactome: R-HSA-6807878;Reactome: R-HSA-3371497;Reactome: R-HSA-2132295;Reactome: R-HSA-2565942;Reactome: R-HSA-8854518;Reactome: R-HSA-380320;Reactome: R-HSA-380284;Reactome: R-HSA-381038;Reactome: R-HSA-380259;Reactome: R-HSA-380270	"Anchoring of the basal body to the plasma membrane";"COPI-independent Golgi-to-ER retrograde traffic";"COPI-mediated anterograde transport";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"MHC class II antigen presentation";"Regulation of PLK1 Activity at G2/M Transition";"AURKA Activation by TPX2";"Recruitment of NuMA to mitotic centrosomes";"Loss of proteins required for interphase microtubule organization from the centrosome";"XBP1(S) activates chaperone genes";"Loss of Nlp from mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes"
Medex_00076254-RA	1	Reactome: R-HSA-6798163	"Choline catabolism"
Medex_00093892-RA	1	Reactome: R-HSA-1296052	"Ca2+ activated K+ channels"
Medex_00081815-RA	7	Reactome: R-HSA-5635838;Reactome: R-HSA-5632684;Reactome: R-HSA-5358346;Reactome: R-HSA-5632681;Reactome: R-HSA-373080;Reactome: R-HSA-5658034;Reactome: R-HSA-5362798	"Activation of SMO";"Hedgehog 'on' state";"Hedgehog ligand biogenesis";"Ligand-receptor interactions";"Class B/2 (Secretin family receptors)";"HHAT G278V abrogates palmitoylation of Hh-Np";"Release of Hh-Np from the secreting cell"
Medex_00049164-RA	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
Medex_00096554-RA	1	Reactome: R-HSA-3214858	"RMTs methylate histone arginines"
Medex_00017028-RA	6	Reactome: R-HSA-176187;Reactome: R-HSA-176974;Reactome: R-HSA-68962;Reactome: R-HSA-68867;Reactome: R-HSA-68949;Reactome: R-HSA-69052	"Activation of ATR in response to replication stress";"Unwinding of DNA";"Activation of the pre-replicative complex";"Assembly of the pre-replicative complex";"Orc1 removal from chromatin";"Switching of origins to a post-replicative state"
Medex_00093843-RA	1	Reactome: R-HSA-1483166	"Synthesis of PA"
Medex_00030947-RA	1	Reactome: R-HSA-390522	"Striated Muscle Contraction"
Medex_00005370-RA	31	MetaCyc: PWY-5994;MetaCyc: PWY-8012;MetaCyc: PWY-5366;MetaCyc: PWY-5142;Reactome: R-HSA-163765;MetaCyc: PWY-5973;MetaCyc: PWY-7858;MetaCyc: PWY-7664;MetaCyc: PWYG-321;MetaCyc: PWY-5966-1;MetaCyc: PWY-6282;MetaCyc: PWY-7663;MetaCyc: PWY-7723;MetaCyc: PWY-8047;Reactome: R-HSA-199220;MetaCyc: PWY-5989;MetaCyc: PWY-5367;MetaCyc: PWY-5147;KEGG: 00780+1.1.1.100+4.2.1.59+2.3.1.41;MetaCyc: PWY-8049;MetaCyc: PWY-6799;MetaCyc: PWY-7746;Reactome: R-HSA-75105;Reactome: R-HSA-9029558;MetaCyc: PWY-5971;MetaCyc: PWY-4381;KEGG: 00061+1.1.1.100+2.3.1.85+4.2.1.59+2.3.1.39+2.3.1.41+3.1.2.14;MetaCyc: PWY-6519;MetaCyc: PWY-7388;MetaCyc: PWY-6113;Reactome: R-HSA-2426168	"Palmitate biosynthesis (animals and fungi, cytoplasm)";"Mupirocin biosynthesis";"Palmitoleate biosynthesis II (plants and bacteria)";"Acyl-[acyl-carrier protein] thioesterase pathway";"ChREBP activates metabolic gene expression";"Cis-vaccenate biosynthesis";"(5Z)-dodecenoate biosynthesis II";"Oleate biosynthesis IV (anaerobic)";"";"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)";"Palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate)";"Gondoate biosynthesis (anaerobic)";"Bacterial bioluminescence";"Bryostatin biosynthesis";"Vitamin B5 (pantothenate) metabolism";"Stearate biosynthesis II (bacteria and plants)";"Petroselinate biosynthesis";"Oleate biosynthesis I (plants)";"Biotin metabolism";"Pederin biosynthesis";"Fatty acid biosynthesis initiation (plant mitochondria)";"Mycobacterial sulfolipid biosynthesis";"Fatty acyl-CoA biosynthesis";"NR1H2 & NR1H3 regulate gene expression linked to lipogenesis";"Palmitate biosynthesis II (bacteria and plant cytoplasm)";"Fatty acid biosynthesis initiation (bacteria and plants)";"Fatty acid biosynthesis";"8-amino-7-oxononanoate biosynthesis I";"Octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast)";"Superpathway of mycolate biosynthesis";"Activation of gene expression by SREBF (SREBP)"
Medex_00051282-RA	1	Reactome: R-HSA-6807878	"COPI-mediated anterograde transport"
Medex_00078981-RA	6	Reactome: R-HSA-6781827;Reactome: R-HSA-72163;Reactome: R-HSA-6781823;Reactome: R-HSA-6782135;Reactome: R-HSA-6782210;MetaCyc: PWY-7511	"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"mRNA Splicing - Major Pathway";"Formation of TC-NER Pre-Incision Complex";"Dual incision in TC-NER";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Protein ubiquitination"
Medex_00046199-RA	6	MetaCyc: PWY-7817;KEGG: 04070+2.7.1.107;KEGG: 00561+2.7.1.107;KEGG: 00564+2.7.1.107;MetaCyc: PWY-7039;Reactome: R-HSA-114508	"Type I lipoteichoic acid biosynthesis (S. aureus)";"Phosphatidylinositol signaling system";"Glycerolipid metabolism";"Glycerophospholipid metabolism";"Phosphatidate metabolism, as a signaling molecule";"Effects of PIP2 hydrolysis"
Medex_00050691-RA	1	KEGG: 00970+6.1.1.3	"Aminoacyl-tRNA biosynthesis"
Medex_00074572-RA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
Medex_00079781-RA	13	MetaCyc: PWY-7210;KEGG: 00240+1.17.4.1;KEGG: 00983+1.17.4.1;MetaCyc: PWY-6545;MetaCyc: PWY-7222;KEGG: 00230+1.17.4.1;MetaCyc: PWY-7227;MetaCyc: PWY-7226;Reactome: R-HSA-499943;MetaCyc: PWY-7198;MetaCyc: PWY-7184;MetaCyc: PWY-7220;KEGG: 00480+1.17.4.1	"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Pyrimidine metabolism";"Drug metabolism - other enzymes";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Guanosine deoxyribonucleotides de novo biosynthesis II";"Purine metabolism";"Adenosine deoxyribonucleotides de novo biosynthesis";"Guanosine deoxyribonucleotides de novo biosynthesis I";"Interconversion of nucleotide di- and triphosphates";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Adenosine deoxyribonucleotides de novo biosynthesis II";"Glutathione metabolism"
Medex_00044976-RA	1	Reactome: R-HSA-70895	"Branched-chain amino acid catabolism"
Medex_00011410-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Medex_00053921-RA	3	Reactome: R-HSA-76071;Reactome: R-HSA-6807505;Reactome: R-HSA-749476	"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA polymerase II transcribes snRNA genes";"RNA Polymerase III Abortive And Retractive Initiation"
Medex_00065395-RA	2	Reactome: R-HSA-202433;Reactome: R-HSA-376176	"Generation of second messenger molecules";"Signaling by ROBO receptors"
Medex_00014418-RA	1	Reactome: R-HSA-388844	"Receptor-type tyrosine-protein phosphatases"
Medex_00046409-RA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
Medex_00005652-RA	1	Reactome: R-HSA-216083	"Integrin cell surface interactions"
Medex_00056851-RA	1	Reactome: R-HSA-432722	"Golgi Associated Vesicle Biogenesis"
Medex_00022320-RA	3	KEGG: 00790+3.1.3.1;MetaCyc: PWY-5491;KEGG: 00730+3.1.3.1	"Folate biosynthesis";"Diethylphosphate degradation";"Thiamine metabolism"
Medex_00024027-RA	3	MetaCyc: PWY-7980;KEGG: 00190+7.1.2.2;KEGG: 00195+7.1.2.2	"ATP biosynthesis";"Oxidative phosphorylation";"Photosynthesis"
Medex_00060819-RA	9	Reactome: R-HSA-8951664;Reactome: R-HSA-6781823;Reactome: R-HSA-5696395;Reactome: R-HSA-6781827;Reactome: R-HSA-5696394;Reactome: R-HSA-6782210;Reactome: R-HSA-6782135;Reactome: R-HSA-110314;Reactome: R-HSA-5696400	"Neddylation";"Formation of TC-NER Pre-Incision Complex";"Formation of Incision Complex in GG-NER";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"DNA Damage Recognition in GG-NER";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Dual incision in TC-NER";"Recognition of DNA damage by PCNA-containing replication complex";"Dual Incision in GG-NER"
Medex_00098119-RA	1	Reactome: R-HSA-5620922	"BBSome-mediated cargo-targeting to cilium"
Medex_00054783-RA	56	Reactome: R-HSA-2467813;Reactome: R-HSA-4641258;Reactome: R-HSA-450408;Reactome: R-HSA-180585;Reactome: R-HSA-382556;Reactome: R-HSA-68949;Reactome: R-HSA-8939236;Reactome: R-HSA-211733;Reactome: R-HSA-9010553;Reactome: R-HSA-8941858;Reactome: R-HSA-5358346;Reactome: R-HSA-5658442;Reactome: R-HSA-202424;Reactome: R-HSA-983168;Reactome: R-HSA-9020702;Reactome: R-HSA-5632684;Reactome: R-HSA-180534;Reactome: R-HSA-1236978;Reactome: R-HSA-349425;Reactome: R-HSA-8852276;Reactome: R-HSA-5610780;Reactome: R-HSA-5607761;Reactome: R-HSA-174178;Reactome: R-HSA-75815;Reactome: R-HSA-8939902;Reactome: R-HSA-195253;Reactome: R-HSA-5610785;Reactome: R-HSA-5689880;Reactome: R-HSA-4608870;Reactome: R-HSA-5689603;Reactome: R-HSA-5668541;Reactome: R-HSA-5687128;Reactome: R-HSA-5610783;Reactome: R-HSA-8854050;Reactome: R-HSA-1236974;Reactome: R-HSA-174084;Reactome: R-HSA-187577;Reactome: R-HSA-174154;Reactome: R-HSA-1169091;Reactome: R-HSA-5607764;Reactome: R-HSA-174184;Reactome: R-HSA-2871837;Reactome: R-HSA-8951664;Reactome: R-HSA-69481;Reactome: R-HSA-5678895;Reactome: R-HSA-350562;Reactome: R-HSA-4641257;Reactome: R-HSA-174113;Reactome: R-HSA-5676590;Reactome: R-HSA-69017;Reactome: R-HSA-5362768;Reactome: R-HSA-69601;Reactome: R-HSA-1234176;Reactome: R-HSA-8948751;Reactome: R-HSA-68827;Reactome: R-HSA-9604323	"Separation of Sister Chromatids";"Degradation of DVL";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Vif-mediated degradation of APOBEC3G";"ABC-family proteins mediated transport";"Orc1 removal from chromatin";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Regulation of expression of SLITs and ROBOs";"Regulation of RUNX3 expression and activity";"Hedgehog ligand biogenesis";"Regulation of RAS by GAPs";"Downstream TCR signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Interleukin-1 signaling";"Hedgehog 'on' state";"Vpu mediated degradation of CD4";"Cross-presentation of soluble exogenous antigens (endosomes)";"Autodegradation of the E3 ubiquitin ligase COP1";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Degradation of GLI1 by the proteasome";"Dectin-1 mediated noncanonical NF-kB signaling";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Ubiquitin-dependent degradation of Cyclin D";"Regulation of RUNX2 expression and activity";"Degradation of beta-catenin by the destruction complex";"GLI3 is processed to GLI3R by the proteasome";"Ub-specific processing proteases";"Asymmetric localization of PCP proteins";"UCH proteinases";"TNFR2 non-canonical NF-kB pathway";"MAPK6/MAPK4 signaling";"Degradation of GLI2 by the proteasome";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"ER-Phagosome pathway";"Autodegradation of Cdh1 by Cdh1:APC/C";"SCF(Skp2)-mediated degradation of p27/p21";"APC/C:Cdc20 mediated degradation of Securin";"Activation of NF-kappaB in B cells";"CLEC7A (Dectin-1) signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"FCERI mediated NF-kB activation";"Neddylation";"G2/M Checkpoints";"Defective CFTR causes cystic fibrosis";"Regulation of ornithine decarboxylase (ODC)";"Degradation of AXIN";"SCF-beta-TrCP mediated degradation of Emi1";"NIK-->noncanonical NF-kB signaling";"CDK-mediated phosphorylation and removal of Cdc6";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of PTEN stability and activity";"CDT1 association with the CDC6:ORC:origin complex";"Negative regulation of NOTCH4 signaling"
Medex_00056280-RA	2	Reactome: R-HSA-418990;Reactome: R-HSA-5218920	"Adherens junctions interactions";"VEGFR2 mediated vascular permeability"
Medex_00025594-RA	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840	"Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation"
Medex_00008221-RA	4	MetaCyc: PWY-8051;KEGG: 00592+3.1.1.32;MetaCyc: PWY-6803;KEGG: 00564+3.1.1.32	"Anandamide biosynthesis I";"alpha-Linolenic acid metabolism";"Phosphatidylcholine acyl editing";"Glycerophospholipid metabolism"
Medex_00031059-RA	12	Reactome: R-HSA-167290;Reactome: R-HSA-167152;Reactome: R-HSA-674695;Reactome: R-HSA-167287;Reactome: R-HSA-167243;Reactome: R-HSA-75955;Reactome: R-HSA-167238;Reactome: R-HSA-6796648;Reactome: R-HSA-112382;Reactome: R-HSA-6804756;Reactome: R-HSA-167246;Reactome: R-HSA-167200	"Pausing and recovery of HIV elongation";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Polymerase II Pre-transcription Events";"HIV elongation arrest and recovery";"Tat-mediated HIV elongation arrest and recovery";"RNA Polymerase II Transcription Elongation";"Pausing and recovery of Tat-mediated HIV elongation";"TP53 Regulates Transcription of DNA Repair Genes";"Formation of RNA Pol II elongation complex";"Regulation of TP53 Activity through Phosphorylation";"Tat-mediated elongation of the HIV-1 transcript";"Formation of HIV-1 elongation complex containing HIV-1 Tat"
Medex_00073176-RA	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
Medex_00086410-RA	1	Reactome: R-HSA-9037629	"Lewis blood group biosynthesis"
Medex_00005709-RA	1	Reactome: R-HSA-2393930	"Phosphate bond hydrolysis by NUDT proteins"
Medex_00059228-RA	5	Reactome: R-HSA-1257604;Reactome: R-HSA-6804757;Reactome: R-HSA-5674400;Reactome: R-HSA-389357;Reactome: R-HSA-5218920	"PIP3 activates AKT signaling";"Regulation of TP53 Degradation";"Constitutive Signaling by AKT1 E17K in Cancer";"CD28 dependent PI3K/Akt signaling";"VEGFR2 mediated vascular permeability"
Medex_00077281-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Medex_00022784-RA	4	Reactome: R-HSA-5358346;Reactome: R-HSA-5678895;Reactome: R-HSA-5362768;Reactome: R-HSA-382556	"Hedgehog ligand biogenesis";"Defective CFTR causes cystic fibrosis";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"ABC-family proteins mediated transport"
Medex_00068678-RA	2	Reactome: R-HSA-2672351;Reactome: R-HSA-5578775	"Stimuli-sensing channels";"Ion homeostasis"
Medex_00009170-RA	3	KEGG: 00460+3.5.1.1;Reactome: R-HSA-8964208;KEGG: 00250+3.5.1.1	"Cyanoamino acid metabolism";"Phenylalanine metabolism";"Alanine, aspartate and glutamate metabolism"
Medex_00088671-RA	2	KEGG: 00240+3.6.1.23;KEGG: 00983+3.6.1.23	"Pyrimidine metabolism";"Drug metabolism - other enzymes"
Medex_00037394-RA	5	Reactome: R-HSA-983170;Reactome: R-HSA-5694530;Reactome: R-HSA-1655829;Reactome: R-HSA-204005;Reactome: R-HSA-2132295	"Antigen Presentation: Folding, assembly and peptide loading of class I MHC";"Cargo concentration in the ER";"Regulation of cholesterol biosynthesis by SREBP (SREBF)";"COPII-mediated vesicle transport";"MHC class II antigen presentation"
Medex_00068411-RA	10	MetaCyc: PWY-1042;Reactome: R-HSA-70171;MetaCyc: PWY-5484;KEGG: 00680+2.7.1.11;MetaCyc: PWY-1861;KEGG: 00052+2.7.1.11;KEGG: 00030+2.7.1.11;MetaCyc: PWY-7385;KEGG: 00051+2.7.1.11;KEGG: 00010+2.7.1.11	"Glycolysis IV (plant cytosol)";"Glycolysis";"Glycolysis II (from fructose 6-phosphate)";"Methane metabolism";"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"Galactose metabolism";"Pentose phosphate pathway";"1,3-propanediol biosynthesis (engineered)";"Fructose and mannose metabolism";"Glycolysis / Gluconeogenesis"
Medex_00062942-RA	2	Reactome: R-HSA-8936459;Reactome: R-HSA-3214841	"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"PKMTs methylate histone lysines"
Medex_00030919-RA	1	Reactome: R-HSA-400253	"Circadian Clock"
Medex_00019636-RA	6	MetaCyc: PWY-5744;Reactome: R-HSA-196780;MetaCyc: PWY-5789;MetaCyc: PWY-4381;MetaCyc: PWY-5743;MetaCyc: PWY-6722	"Glyoxylate assimilation";"Biotin transport and metabolism";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Fatty acid biosynthesis initiation (bacteria and plants)";"3-hydroxypropanoate cycle";"Candicidin biosynthesis"
Medex_00077552-RA	3	MetaCyc: PWY-6596;Reactome: R-HSA-74217;KEGG: 00230+3.5.4.6	"Adenosine nucleotides degradation I";"Purine salvage";"Purine metabolism"
Medex_00011781-RA	3	Reactome: R-HSA-1989781;Reactome: R-HSA-381340;Reactome: R-HSA-212436	"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation";"Generic Transcription Pathway"
Medex_00004877-RA	1	Reactome: R-HSA-186797	"Signaling by PDGF"
Medex_00083253-RA	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
Medex_00066191-RA	2	Reactome: R-HSA-425366;Reactome: R-HSA-1483191	"Transport of bile salts and organic acids, metal ions and amine compounds";"Synthesis of PC"
Medex_00008931-RA	1	Reactome: R-HSA-6798163	"Choline catabolism"
Medex_00014256-RA	1	Reactome: R-HSA-2129379	"Molecules associated with elastic fibres"
Medex_00092223-RA	1	Reactome: R-HSA-1474228	"Degradation of the extracellular matrix"
Medex_00054867-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Medex_00001729-RA	2	MetaCyc: PWY-6854;Reactome: R-HSA-3299685	"Ethylene biosynthesis III (microbes)";"Detoxification of Reactive Oxygen Species"
Medex_00046352-RA	1	Reactome: R-HSA-6799198	"Complex I biogenesis"
Medex_00068683-RA	8	Reactome: R-HSA-180024;Reactome: R-HSA-432040;Reactome: R-HSA-5610787;Reactome: R-HSA-164378;Reactome: R-HSA-442720;Reactome: R-HSA-983231;Reactome: R-HSA-381676;Reactome: R-HSA-163615	"DARPP-32 events";"Vasopressin regulates renal water homeostasis via Aquaporins";"Hedgehog 'off' state";"PKA activation in glucagon signalling";"CREB1 phosphorylation through the activation of Adenylate Cyclase";"Factors involved in megakaryocyte development and platelet production";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"PKA activation"
Medex_00074331-RA	1	Reactome: R-HSA-2022377	"Metabolism of Angiotensinogen to Angiotensins"
Medex_00018396-RA	10	Reactome: R-HSA-2024096;KEGG: 00604+3.2.1.23;KEGG: 00511+3.2.1.23;MetaCyc: PWY-6807;Reactome: R-HSA-6798695;KEGG: 00531+3.2.1.23;KEGG: 00052+3.2.1.23;Reactome: R-HSA-2206292;KEGG: 00600+3.2.1.23;Reactome: R-HSA-2160916	"HS-GAG degradation";"Glycosphingolipid biosynthesis - ganglio series";"Other glycan degradation";"Xyloglucan degradation II (exoglucanase)";"Neutrophil degranulation";"Glycosaminoglycan degradation";"Galactose metabolism";"MPS VII - Sly syndrome";"Sphingolipid metabolism";"Hyaluronan uptake and degradation"
Medex_00009124-RA	1	Reactome: R-HSA-6784531	"tRNA processing in the nucleus"
Medex_00046046-RA	8	Reactome: R-HSA-68616;Reactome: R-HSA-68949;Reactome: R-HSA-68867;Reactome: R-HSA-68962;Reactome: R-HSA-113507;Reactome: R-HSA-68689;Reactome: R-HSA-176187;Reactome: R-HSA-68827	"Assembly of the ORC complex at the origin of replication";"Orc1 removal from chromatin";"Assembly of the pre-replicative complex";"Activation of the pre-replicative complex";"E2F-enabled inhibition of pre-replication complex formation";"CDC6 association with the ORC:origin complex";"Activation of ATR in response to replication stress";"CDT1 association with the CDC6:ORC:origin complex"
Medex_00006000-RA	1	Reactome: R-HSA-83936	"Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"
Medex_00003270-RA	1	Reactome: R-HSA-426117	"Cation-coupled Chloride cotransporters"
Medex_00025747-RA	3	KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway"
Medex_00019487-RA	3	KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16	"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation"
Medex_00043381-RA	2	Reactome: R-HSA-2151201;KEGG: 00970+6.1.1.14	"Transcriptional activation of mitochondrial biogenesis";"Aminoacyl-tRNA biosynthesis"
Medex_00079518-RA	1	Reactome: R-HSA-9609523	"Insertion of tail-anchored proteins into the endoplasmic reticulum membrane"
Medex_00003885-RA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Medex_00073194-RA	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
Medex_00087512-RA	7	MetaCyc: PWY-6351;MetaCyc: PWY-7039;KEGG: 00562+3.1.4.11;Reactome: R-HSA-1855204;KEGG: 04070+3.1.4.11;MetaCyc: PWY-8052;MetaCyc: PWY-6367	"D-myo-inositol (1,4,5)-trisphosphate biosynthesis";"Phosphatidate metabolism, as a signaling molecule";"Inositol phosphate metabolism";"Synthesis of IP3 and IP4 in the cytosol";"Phosphatidylinositol signaling system";"2-arachidonoylglycerol biosynthesis";"D-myo-inositol-5-phosphate metabolism"
Medex_00020354-RA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00076711-RA	2	Reactome: R-HSA-72163;Reactome: R-HSA-72165	"mRNA Splicing - Major Pathway";"mRNA Splicing - Minor Pathway"
Medex_00078357-RA	2	Reactome: R-HSA-8949664;Reactome: R-HSA-8949215	"Processing of SMDT1";"Mitochondrial calcium ion transport"
Medex_00032908-RA	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
Medex_00019550-RA	1	Reactome: R-HSA-211981	"Xenobiotics"
Medex_00081441-RA	7	KEGG: 00500+2.4.1.25;MetaCyc: PWY-5941;MetaCyc: PWY-6737;Reactome: R-HSA-6798695;Reactome: R-HSA-70221;MetaCyc: PWY-7238;MetaCyc: PWY-6724	"Starch and sucrose metabolism";"Glycogen degradation II";"Starch degradation V";"Neutrophil degranulation";"Glycogen breakdown (glycogenolysis)";"Sucrose biosynthesis II";"Starch degradation II"
Medex_00019118-RA	2	Reactome: R-HSA-6784531;Reactome: R-HSA-6791226	"tRNA processing in the nucleus";"Major pathway of rRNA processing in the nucleolus and cytosol"
Medex_00010751-RA	1	Reactome: R-HSA-70921	"Histidine catabolism"
Medex_00042161-RA	7	MetaCyc: PWY-4702;KEGG: 00521+3.1.3.25;MetaCyc: PWY-6363;Reactome: R-HSA-1855183;MetaCyc: PWY-2301;KEGG: 04070+3.1.3.25;KEGG: 00562+3.1.3.25	"Phytate degradation I";"Streptomycin biosynthesis";"D-myo-inositol (1,4,5)-trisphosphate degradation";"Synthesis of IP2, IP, and Ins in the cytosol";"Myo-inositol biosynthesis";"Phosphatidylinositol signaling system";"Inositol phosphate metabolism"
Medex_00015018-RA	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
Medex_00022562-RA	1	Reactome: R-HSA-8876725	"Protein methylation"
Medex_00083149-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Medex_00010395-RA	3	Reactome: R-HSA-74259;Reactome: R-HSA-73621;Reactome: R-HSA-196807	"Purine catabolism";"Pyrimidine catabolism";"Nicotinate metabolism"
Medex_00013454-RA	12	KEGG: 00030+4.1.2.13;MetaCyc: PWY-6142;KEGG: 00680+4.1.2.13;MetaCyc: PWY-1042;Reactome: R-HSA-70171;Reactome: R-HSA-70263;KEGG: 00710+4.1.2.13;MetaCyc: PWY-5484;MetaCyc: PWY-1861;KEGG: 00051+4.1.2.13;KEGG: 00010+4.1.2.13;MetaCyc: PWY-7385	"Pentose phosphate pathway";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Methane metabolism";"Glycolysis IV (plant cytosol)";"Glycolysis";"Gluconeogenesis";"Carbon fixation in photosynthetic organisms";"Glycolysis II (from fructose 6-phosphate)";"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"Fructose and mannose metabolism";"Glycolysis / Gluconeogenesis";"1,3-propanediol biosynthesis (engineered)"
Medex_00067521-RA	2	Reactome: R-HSA-3214847;Reactome: R-HSA-6804758	"HATs acetylate histones";"Regulation of TP53 Activity through Acetylation"
Medex_00008495-RA	6	Reactome: R-HSA-9640463;MetaCyc: PWY-5884;KEGG: 00073+1.2.1.84;MetaCyc: PWY-7656;MetaCyc: PWY-7782;MetaCyc: PWY-6733	"Wax biosynthesis";"Wax esters biosynthesis I";"Cutin, suberine and wax biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Plasmalogen biosynthesis";"Sporopollenin precursors biosynthesis"
Medex_00022646-RA	14	MetaCyc: PWY-8051;MetaCyc: PWY-7409;MetaCyc: PWY-6803;KEGG: 00590+3.1.1.4;KEGG: 00565+3.1.1.4;Reactome: R-HSA-975634;MetaCyc: PWY-7416;MetaCyc: PWY-8053;MetaCyc: PWY-7417;KEGG: 00591+3.1.1.4;KEGG: 00592+3.1.1.4;KEGG: 00564+3.1.1.4+3.1.1.5;Reactome: R-HSA-1482788;MetaCyc: PWY-7783	"Anandamide biosynthesis I";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Phosphatidylcholine acyl editing";"Arachidonic acid metabolism";"Ether lipid metabolism";"Retinoid metabolism and transport";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Anandamide biosynthesis II";"Phospholipid remodeling (phosphatidate, yeast)";"Linoleic acid metabolism";"alpha-Linolenic acid metabolism";"Glycerophospholipid metabolism";"Acyl chain remodelling of PC";"Plasmalogen degradation"
Medex_00044631-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Medex_00022376-RA	7	KEGG: 00600+2.4.1.80;MetaCyc: PWY-7836;MetaCyc: PWY-7841;Reactome: R-HSA-1660662;MetaCyc: PWY-5129;MetaCyc: PWY-7838;MetaCyc: PWY-7839	"Sphingolipid metabolism";"Ganglio-series glycosphingolipids biosynthesis";"Neolacto-series glycosphingolipids biosynthesis";"Glycosphingolipid metabolism";"Sphingolipid biosynthesis (plants)";"Globo-series glycosphingolipids biosynthesis";"Lacto-series glycosphingolipids biosynthesis"
Medex_00002917-RA	4	KEGG: 00520+3.2.1.14;MetaCyc: PWY-6855;MetaCyc: PWY-7822;MetaCyc: PWY-6902	"Amino sugar and nucleotide sugar metabolism";"Chitin degradation I (archaea)";"Chitin degradation III (Serratia)";"Chitin degradation II (Vibrio)"
Medex_00047473-RA	1	Reactome: R-HSA-426486	"Small interfering RNA (siRNA) biogenesis"
Medex_00050507-RA	3	Reactome: R-HSA-193648;Reactome: R-HSA-194840;Reactome: R-HSA-416482	"NRAGE signals death through JNK";"Rho GTPase cycle";"G alpha (12/13) signalling events"
Medex_00038618-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Medex_00042199-RA	14	Reactome: R-HSA-426496;Reactome: R-HSA-203927;Reactome: R-HSA-5628897;Reactome: R-HSA-9018519;Reactome: R-HSA-426486;Reactome: R-HSA-1912408;Reactome: R-HSA-8934593;Reactome: R-HSA-5687128;Reactome: R-HSA-8986944;Reactome: R-HSA-8943723;Reactome: R-HSA-9022692;Reactome: R-HSA-9029569;Reactome: R-HSA-8948700;Reactome: R-HSA-4086398	"Post-transcriptional silencing by small RNAs";"MicroRNA (miRNA) biogenesis";"TP53 Regulates Metabolic Genes";"Estrogen-dependent gene expression";"Small interfering RNA (siRNA) biogenesis";"Pre-NOTCH Transcription and Translation";"Regulation of RUNX1 Expression and Activity";"MAPK6/MAPK4 signaling";"Transcriptional Regulation by MECP2";"Regulation of PTEN mRNA translation";"Regulation of MECP2 expression and activity";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"Ca2+ pathway"
Medex_00023692-RA	2	MetaCyc: PWY-5905;Reactome: R-HSA-204626	"Hypusine biosynthesis";"Hypusine synthesis from eIF5A-lysine"
Medex_00016269-RA	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
Medex_00000691-RA	1	Reactome: R-HSA-430039	"mRNA decay by 5' to 3' exoribonuclease"
Medex_00027937-RA	1	Reactome: R-HSA-211945	"Phase I - Functionalization of compounds"
Medex_00058938-RA	3	Reactome: R-HSA-71336;KEGG: 00030+1.1.1.44;KEGG: 00480+1.1.1.44	"Pentose phosphate pathway";"Pentose phosphate pathway";"Glutathione metabolism"
Medex_00036021-RA	5	MetaCyc: PWY-6527;KEGG: 00561+3.2.1.22;KEGG: 00603+3.2.1.22;KEGG: 00600+3.2.1.22;KEGG: 00052+3.2.1.22	"Stachyose degradation";"Glycerolipid metabolism";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Sphingolipid metabolism";"Galactose metabolism"
Medex_00015897-RA	2	Reactome: R-HSA-204005;Reactome: R-HSA-8876198	"COPII-mediated vesicle transport";"RAB GEFs exchange GTP for GDP on RABs"
Medex_00025982-RA	6	MetaCyc: PWY-6854;Reactome: R-HSA-8950505;Reactome: R-HSA-2151201;Reactome: R-HSA-9615017;Reactome: R-HSA-8862803;Reactome: R-HSA-3299685	"Ethylene biosynthesis III (microbes)";"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation";"Transcriptional activation of mitochondrial biogenesis";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models";"Detoxification of Reactive Oxygen Species"
Medex_00001243-RA	2	MetaCyc: PWY-6788;KEGG: 00500+3.2.1.4	"Cellulose degradation II (fungi)";"Starch and sucrose metabolism"
Medex_00074099-RA	3	Reactome: R-HSA-3108214;Reactome: R-HSA-5696395;Reactome: R-HSA-5696394	"SUMOylation of DNA damage response and repair proteins";"Formation of Incision Complex in GG-NER";"DNA Damage Recognition in GG-NER"
Medex_00076909-RA	6	Reactome: R-HSA-176974;Reactome: R-HSA-68962;Reactome: R-HSA-176187;Reactome: R-HSA-69052;Reactome: R-HSA-68867;Reactome: R-HSA-68949	"Unwinding of DNA";"Activation of the pre-replicative complex";"Activation of ATR in response to replication stress";"Switching of origins to a post-replicative state";"Assembly of the pre-replicative complex";"Orc1 removal from chromatin"
Medex_00077208-RA	7	Reactome: R-HSA-1483148;MetaCyc: PWY-3561;KEGG: 00564+3.1.4.4;Reactome: R-HSA-2029485;Reactome: R-HSA-1483166;KEGG: 00565+3.1.4.4;MetaCyc: PWY-7039	"Synthesis of PG";"Choline biosynthesis III";"Glycerophospholipid metabolism";"Role of phospholipids in phagocytosis";"Synthesis of PA";"Ether lipid metabolism";"Phosphatidate metabolism, as a signaling molecule"
Medex_00066509-RA	3	Reactome: R-HSA-6799198;Reactome: R-HSA-611105;Reactome: R-HSA-1268020	"Complex I biogenesis";"Respiratory electron transport";"Mitochondrial protein import"
Medex_00003338-RA	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
Medex_00011036-RA	13	Reactome: R-HSA-2214320;Reactome: R-HSA-3000157;Reactome: R-HSA-1474244;Reactome: R-HSA-419037;Reactome: R-HSA-3000178;Reactome: R-HSA-3000171;Reactome: R-HSA-186797;Reactome: R-HSA-1650814;Reactome: R-HSA-1442490;Reactome: R-HSA-216083;Reactome: R-HSA-2243919;Reactome: R-HSA-8948216;Reactome: R-HSA-2022090	"Anchoring fibril formation";"Laminin interactions";"Extracellular matrix organization";"NCAM1 interactions";"ECM proteoglycans";"Non-integrin membrane-ECM interactions";"Signaling by PDGF";"Collagen biosynthesis and modifying enzymes";"Collagen degradation";"Integrin cell surface interactions";"Crosslinking of collagen fibrils";"Collagen chain trimerization";"Assembly of collagen fibrils and other multimeric structures"
Medex_00017179-RA	3	KEGG: 00480+1.1.1.44;Reactome: R-HSA-71336;KEGG: 00030+1.1.1.44	"Glutathione metabolism";"Pentose phosphate pathway";"Pentose phosphate pathway"
MedexCellulase04-PA	2	MetaCyc: PWY-6788;KEGG: 00500+3.2.1.4	"Cellulose degradation II (fungi)";"Starch and sucrose metabolism"
Medex_00086120-RA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00070539-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Medex_00031731-RA	1	KEGG: 00051+4.2.1.68	"Fructose and mannose metabolism"
Medex_00044665-RA	2	Reactome: R-HSA-983231;Reactome: R-HSA-5205685	"Factors involved in megakaryocyte development and platelet production";"Pink/Parkin Mediated Mitophagy"
Medex_00041092-RA	1	Reactome: R-HSA-6803157	"Antimicrobial peptides"
Medex_00004876-RA	1	Reactome: R-HSA-186797	"Signaling by PDGF"
Medex_00065092-RA	3	Reactome: R-HSA-5358493;MetaCyc: PWY-6482;MetaCyc: PWY-7546	"Synthesis of diphthamide-EEF2";"Diphthamide biosynthesis I (archaea)";"Diphthamide biosynthesis II (eukaryotes)"
Medex_00074819-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Medex_00091865-RA	13	Reactome: R-HSA-192823;Reactome: R-HSA-975957;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-156902;Reactome: R-HSA-9633012;Reactome: R-HSA-1799339;Reactome: R-HSA-72689;Reactome: R-HSA-72764;Reactome: R-HSA-975956;Reactome: R-HSA-72706;Reactome: R-HSA-6791226;Reactome: R-HSA-2408557	"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Peptide chain elongation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"SRP-dependent cotranslational protein targeting to membrane";"Formation of a pool of free 40S subunits";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Major pathway of rRNA processing in the nucleolus and cytosol";"Selenocysteine synthesis"
Medex_00016410-RA	1	Reactome: R-HSA-5689880	"Ub-specific processing proteases"
Medex_00057369-RA	12	KEGG: 00500+2.7.7.9;KEGG: 00520+2.7.7.9;MetaCyc: PWY-7238;MetaCyc: PWY-7817;KEGG: 00040+2.7.7.9;KEGG: 00561+2.7.7.9;MetaCyc: PWY-7343;MetaCyc: PWY-3801;Reactome: R-HSA-3322077;Reactome: R-HSA-173599;KEGG: 00052+2.7.7.9;MetaCyc: PWY-6527	"Starch and sucrose metabolism";"Amino sugar and nucleotide sugar metabolism";"Sucrose biosynthesis II";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Pentose and glucuronate interconversions";"Glycerolipid metabolism";"UDP-alpha-D-glucose biosynthesis I";"Sucrose degradation II (sucrose synthase)";"Glycogen synthesis";"Formation of the active cofactor, UDP-glucuronate";"Galactose metabolism";"Stachyose degradation"
Medex_00044348-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00090784-RA	3	Reactome: R-HSA-2142691;MetaCyc: PWY-7533;Reactome: R-HSA-5423646	"Synthesis of Leukotrienes (LT) and Eoxins (EX)";"Gliotoxin biosynthesis";"Aflatoxin activation and detoxification"
Medex_00001963-RA	1	Reactome: R-HSA-5662702	"Melanin biosynthesis"
Medex_00011954-RA	1	Reactome: R-HSA-1660499	"Synthesis of PIPs at the plasma membrane"
Medex_00027046-RA	2	Reactome: R-HSA-390471;Reactome: R-HSA-1660662	"Association of TriC/CCT with target proteins during biosynthesis";"Glycosphingolipid metabolism"
Medex_00053477-RA	2	Reactome: R-HSA-917729;Reactome: R-HSA-9610379	"Endosomal Sorting Complex Required For Transport (ESCRT)";"HCMV Late Events"
Medex_00031654-RA	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
Medex_00030955-RA	1	Reactome: R-HSA-391908	"Prostanoid ligand receptors"
Medex_00018883-RA	1	Reactome: R-HSA-216083	"Integrin cell surface interactions"
Medex_00044350-RA	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840	"Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation"
Medex_00009123-RA	1	Reactome: R-HSA-6784531	"tRNA processing in the nucleus"
Medex_00004400-RA	1	Reactome: R-HSA-2024096	"HS-GAG degradation"
Medex_00031135-RA	5	Reactome: R-HSA-8957275;Reactome: R-HSA-901042;Reactome: R-HSA-381426;Reactome: R-HSA-532668;Reactome: R-HSA-879415	"Post-translational protein phosphorylation";"Calnexin/calreticulin cycle";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"N-glycan trimming in the ER and Calnexin/Calreticulin cycle";"Advanced glycosylation endproduct receptor signaling"
Medex_00019673-RA	1	Reactome: R-HSA-425561	"Sodium/Calcium exchangers"
Medex_00089879-RA	1	Reactome: R-HSA-4615885	"SUMOylation of DNA replication proteins"
Medex_00091941-RA	2	Reactome: R-HSA-2672351;Reactome: R-HSA-5578775	"Stimuli-sensing channels";"Ion homeostasis"
Medex_00037901-RA	7	KEGG: 00270+6.3.2.2;KEGG: 00480+6.3.2.2;Reactome: R-HSA-5578999;MetaCyc: PWY-8043;MetaCyc: PWY-7255;MetaCyc: PWY-6840;Reactome: R-HSA-174403	"Cysteine and methionine metabolism";"Glutathione metabolism";"Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD)";"Ophthalmate biosynthesis";"Ergothioneine biosynthesis I (bacteria)";"Homoglutathione biosynthesis";"Glutathione synthesis and recycling"
Medex_00033380-RA	1	Reactome: R-HSA-4551638	"SUMOylation of chromatin organization proteins"
Medex_00077570-RA	5	Reactome: R-HSA-204005;Reactome: R-HSA-6811438;Reactome: R-HSA-6811434;Reactome: R-HSA-6807878;Reactome: R-HSA-6811440	"COPII-mediated vesicle transport";"Intra-Golgi traffic";"COPI-dependent Golgi-to-ER retrograde traffic";"COPI-mediated anterograde transport";"Retrograde transport at the Trans-Golgi-Network"
Medex_00023799-RA	1	Reactome: R-HSA-5658442	"Regulation of RAS by GAPs"
Medex_00076569-RA	4	Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-975957;Reactome: R-HSA-72764	"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination"
Medex_00081077-RA	1	Reactome: R-HSA-381038	"XBP1(S) activates chaperone genes"
Medex_00051039-RA	24	Reactome: R-HSA-392451;KEGG: 04151+2.7.11.1;Reactome: R-HSA-202424;Reactome: R-HSA-5674400;Reactome: R-HSA-389357;Reactome: R-HSA-5218920;KEGG: 05163+2.7.11.1;Reactome: R-HSA-5625740;Reactome: R-HSA-354192;Reactome: R-HSA-1257604;KEGG: 04150+2.7.11.1;Reactome: R-HSA-2730905;KEGG: 04714+2.7.11.1;Reactome: R-HSA-5218921;Reactome: R-HSA-444257;Reactome: R-HSA-9634635;KEGG: 04926+2.7.11.1;Reactome: R-HSA-6804757;KEGG: 05170+2.7.11.1;Reactome: R-HSA-2871837;KEGG: 05165+2.7.11.1;Reactome: R-HSA-5607764;Reactome: R-HSA-114604;Reactome: R-HSA-165158	"G beta:gamma signalling through PI3Kgamma";"PI3K-Akt signaling pathway";"Downstream TCR signaling";"Constitutive Signaling by AKT1 E17K in Cancer";"CD28 dependent PI3K/Akt signaling";"VEGFR2 mediated vascular permeability";"Human cytomegalovirus infection";"RHO GTPases activate PKNs";"Integrin signaling";"PIP3 activates AKT signaling";"mTOR signaling pathway";"Role of LAT2/NTAL/LAB on calcium mobilization";"Thermogenesis";"VEGFR2 mediated cell proliferation";"RSK activation";"Estrogen-stimulated signaling through PRKCZ";"Relaxin signaling pathway";"Regulation of TP53 Degradation";"Human immunodeficiency virus 1 infection";"FCERI mediated NF-kB activation";"Human papillomavirus infection";"CLEC7A (Dectin-1) signaling";"GPVI-mediated activation cascade";"Activation of AKT2"
Medex_00069136-RA	2	Reactome: R-HSA-6798695;Reactome: R-HSA-1660662	"Neutrophil degranulation";"Glycosphingolipid metabolism"
Medex_00014036-RA	33	Reactome: R-HSA-159236;Reactome: R-HSA-6784531;Reactome: R-HSA-3108214;Reactome: R-HSA-9609690;Reactome: R-HSA-9610379;Reactome: R-HSA-5619107;Reactome: R-HSA-4570464;Reactome: R-HSA-4085377;Reactome: R-HSA-3301854;Reactome: R-HSA-180910;Reactome: R-HSA-2500257;Reactome: R-HSA-5578749;Reactome: R-HSA-168276;Reactome: R-HSA-3371453;Reactome: R-HSA-4615885;Reactome: R-HSA-180746;Reactome: R-HSA-165054;Reactome: R-HSA-191859;Reactome: R-HSA-168325;Reactome: R-HSA-141444;Reactome: R-HSA-4551638;Reactome: R-HSA-170822;Reactome: R-HSA-3232142;Reactome: R-HSA-168271;Reactome: R-HSA-5663220;Reactome: R-HSA-159230;Reactome: R-HSA-159227;Reactome: R-HSA-68877;Reactome: R-HSA-9648025;Reactome: R-HSA-159231;Reactome: R-HSA-168333;Reactome: R-HSA-1169408;Reactome: R-HSA-2467813	"Transport of Mature mRNA derived from an Intron-Containing Transcript";"tRNA processing in the nucleus";"SUMOylation of DNA damage response and repair proteins";"HCMV Early Events";"HCMV Late Events";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"SUMOylation of RNA binding proteins";"SUMOylation of SUMOylation proteins";"Nuclear Pore Complex (NPC) Disassembly";"Vpr-mediated nuclear import of PICs";"Resolution of Sister Chromatid Cohesion";"Transcriptional regulation by small RNAs";"NS1 Mediated Effects on Host Pathways";"Regulation of HSF1-mediated heat shock response";"SUMOylation of DNA replication proteins";"Nuclear import of Rev protein";"Rev-mediated nuclear export of HIV RNA";"snRNP Assembly";"Viral Messenger RNA Synthesis";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"SUMOylation of chromatin organization proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"SUMOylation of ubiquitinylation proteins";"Transport of Ribonucleoproteins into the Host Nucleus";"RHO GTPases Activate Formins";"Transport of the SLBP Dependant Mature mRNA";"Transport of the SLBP independent Mature mRNA";"Mitotic Prometaphase";"EML4 and NUDC in mitotic spindle formation";"Transport of Mature mRNA Derived from an Intronless Transcript";"NEP/NS2 Interacts with the Cellular Export Machinery";"ISG15 antiviral mechanism";"Separation of Sister Chromatids"
Medex_00038732-RA	6	Reactome: R-HSA-68962;Reactome: R-HSA-176974;Reactome: R-HSA-176187;Reactome: R-HSA-69052;Reactome: R-HSA-68867;Reactome: R-HSA-68949	"Activation of the pre-replicative complex";"Unwinding of DNA";"Activation of ATR in response to replication stress";"Switching of origins to a post-replicative state";"Assembly of the pre-replicative complex";"Orc1 removal from chromatin"
Medex_00028549-RA	3	Reactome: R-HSA-6798695;MetaCyc: PWY-6807;KEGG: 00511+3.2.1.51	"Neutrophil degranulation";"Xyloglucan degradation II (exoglucanase)";"Other glycan degradation"
Medex_00007890-RA	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
Medex_00056794-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Medex_00078487-RA	3	Reactome: R-HSA-159236;Reactome: R-HSA-73856;Reactome: R-HSA-72187	"Transport of Mature mRNA derived from an Intron-Containing Transcript";"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing"
Medex_00009487-RA	2	Reactome: R-HSA-71336;KEGG: 00030+2.7.1.15	"Pentose phosphate pathway";"Pentose phosphate pathway"
Medex_00008747-RA	6	Reactome: R-HSA-429958;Reactome: R-HSA-450385;Reactome: R-HSA-450604;Reactome: R-HSA-450513;Reactome: R-HSA-380994;Reactome: R-HSA-6791226	"mRNA decay by 3' to 5' exoribonuclease";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"KSRP (KHSRP) binds and destabilizes mRNA";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"ATF4 activates genes in response to endoplasmic reticulum stress";"Major pathway of rRNA processing in the nucleolus and cytosol"
Medex_00021013-RA	1	Reactome: R-HSA-6798163	"Choline catabolism"
Medex_00023122-RA	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
Medex_00041113-RA	2	Reactome: R-HSA-429947;Reactome: R-HSA-6804115	"Deadenylation of mRNA";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"
Medex_00079887-RA	7	Reactome: R-HSA-68949;Reactome: R-HSA-68867;Reactome: R-HSA-68827;Reactome: R-HSA-68689;Reactome: R-HSA-176187;Reactome: R-HSA-69205;Reactome: R-HSA-68962	"Orc1 removal from chromatin";"Assembly of the pre-replicative complex";"CDT1 association with the CDC6:ORC:origin complex";"CDC6 association with the ORC:origin complex";"Activation of ATR in response to replication stress";"G1/S-Specific Transcription";"Activation of the pre-replicative complex"
Medex_00055254-RA	3	Reactome: R-HSA-5663213;Reactome: R-HSA-4420097;Reactome: R-HSA-2029482	"RHO GTPases Activate WASPs and WAVEs";"VEGFA-VEGFR2 Pathway";"Regulation of actin dynamics for phagocytic cup formation"
Medex_00065563-RA	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
Medex_00049181-RA	9	Reactome: R-HSA-442982;Reactome: R-HSA-9609736;Reactome: R-HSA-5673001;Reactome: R-HSA-3928662;Reactome: R-HSA-438066;Reactome: R-HSA-9617324;Reactome: R-HSA-9620244;Reactome: R-HSA-8849932;Reactome: R-HSA-6794361	"Ras activation upon Ca2+ influx through NMDA receptor";"Assembly and cell surface presentation of NMDA receptors";"RAF/MAP kinase cascade";"EPHB-mediated forward signaling";"Unblocking of NMDA receptors, glutamate binding and activation";"Negative regulation of NMDA receptor-mediated neuronal transmission";"Long-term potentiation";"Synaptic adhesion-like molecules";"Neurexins and neuroligins"
Medex_00020210-RA	7	Reactome: R-HSA-2565942;Reactome: R-HSA-380259;Reactome: R-HSA-380270;Reactome: R-HSA-380320;Reactome: R-HSA-8854518;Reactome: R-HSA-5620912;Reactome: R-HSA-380284	"Regulation of PLK1 Activity at G2/M Transition";"Loss of Nlp from mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes";"Recruitment of NuMA to mitotic centrosomes";"AURKA Activation by TPX2";"Anchoring of the basal body to the plasma membrane";"Loss of proteins required for interphase microtubule organization from the centrosome"
Medex_00100459-RA	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
Medex_00071587-RA	2	KEGG: 00500+3.2.1.28;Reactome: R-HSA-189085	"Starch and sucrose metabolism";"Digestion of dietary carbohydrate"
Medex_00050673-RA	3	Reactome: R-HSA-72187;Reactome: R-HSA-73856;Reactome: R-HSA-159236	"mRNA 3'-end processing";"RNA Polymerase II Transcription Termination";"Transport of Mature mRNA derived from an Intron-Containing Transcript"
Medex_00065806-RA	8	KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04660+2.7.10.2;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1	"Relaxin signaling pathway";"Human cytomegalovirus infection";"PI3K-Akt signaling pathway";"Thermogenesis";"Human immunodeficiency virus 1 infection";"T cell receptor signaling pathway";"Human papillomavirus infection";"mTOR signaling pathway"
Medex_00074180-RA	12	Reactome: R-HSA-9013695;Reactome: R-HSA-2122947;Reactome: R-HSA-2644606;Reactome: R-HSA-350054;Reactome: R-HSA-5250924;Reactome: R-HSA-8941856;Reactome: R-HSA-210744;Reactome: R-HSA-73762;Reactome: R-HSA-1912408;Reactome: R-HSA-9013508;Reactome: R-HSA-2894862;Reactome: R-HSA-3214847	"NOTCH4 Intracellular Domain Regulates Transcription";"NOTCH1 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Notch-HLH transcription pathway";"B-WICH complex positively regulates rRNA expression";"RUNX3 regulates NOTCH signaling";"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"RNA Polymerase I Transcription Initiation";"Pre-NOTCH Transcription and Translation";"NOTCH3 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"HATs acetylate histones"
Medex_00066732-RA	6	MetaCyc: PWY-6733;MetaCyc: PWY-7782;MetaCyc: PWY-7656;KEGG: 00073+1.2.1.84;Reactome: R-HSA-9640463;MetaCyc: PWY-5884	"Sporopollenin precursors biosynthesis";"Plasmalogen biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax biosynthesis";"Wax esters biosynthesis I"
Medex_00075733-RA	1	Reactome: R-HSA-3214858	"RMTs methylate histone arginines"
Medex_00057399-RA	6	KEGG: 00604+3.2.1.23;KEGG: 00600+3.2.1.23;KEGG: 00511+3.2.1.23;MetaCyc: PWY-6807;KEGG: 00531+3.2.1.23;KEGG: 00052+3.2.1.23	"Glycosphingolipid biosynthesis - ganglio series";"Sphingolipid metabolism";"Other glycan degradation";"Xyloglucan degradation II (exoglucanase)";"Glycosaminoglycan degradation";"Galactose metabolism"
Medex_00056195-RA	2	Reactome: R-HSA-418990;Reactome: R-HSA-5218920	"Adherens junctions interactions";"VEGFR2 mediated vascular permeability"
Medex_00099966-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00077121-RA	5	Reactome: R-HSA-1445148;Reactome: R-HSA-983189;Reactome: R-HSA-2132295;Reactome: R-HSA-5620924;Reactome: R-HSA-6811434	"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Kinesins";"MHC class II antigen presentation";"Intraflagellar transport";"COPI-dependent Golgi-to-ER retrograde traffic"
Medex_00028501-RA	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
Medex_00000491-RA	2	Reactome: R-HSA-1660662;Reactome: R-HSA-390471	"Glycosphingolipid metabolism";"Association of TriC/CCT with target proteins during biosynthesis"
Medex_00039271-RA	2	Reactome: R-HSA-8939243;Reactome: R-HSA-3214858	"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RMTs methylate histone arginines"
Medex_00027059-RA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Medex_00052365-RA	3	Reactome: R-HSA-3322077;MetaCyc: PWY-5067;KEGG: 00500+2.4.1.11	"Glycogen synthesis";"Glycogen biosynthesis II (from UDP-D-Glucose)";"Starch and sucrose metabolism"
Medex_00019820-RA	1	MetaCyc: PWY-6938	"NADH repair"
Medex_00034494-RA	3	Reactome: R-HSA-4420097;Reactome: R-HSA-2029482;Reactome: R-HSA-5663213	"VEGFA-VEGFR2 Pathway";"Regulation of actin dynamics for phagocytic cup formation";"RHO GTPases Activate WASPs and WAVEs"
Medex_00055599-RA	2	KEGG: 00670+2.1.2.9;KEGG: 00970+2.1.2.9	"One carbon pool by folate";"Aminoacyl-tRNA biosynthesis"
Medex_00004414-RA	5	Reactome: R-HSA-8856828;Reactome: R-HSA-2029482;Reactome: R-HSA-6798695;Reactome: R-HSA-3928662;Reactome: R-HSA-5663213	"Clathrin-mediated endocytosis";"Regulation of actin dynamics for phagocytic cup formation";"Neutrophil degranulation";"EPHB-mediated forward signaling";"RHO GTPases Activate WASPs and WAVEs"
Medex_00055388-RA	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
Medex_00025863-RA	12	MetaCyc: PWY-5857;MetaCyc: PWY-6708;MetaCyc: PWY-5871;MetaCyc: PWY-5873;KEGG: 00130+1.14.99.60;Reactome: R-HSA-2142789;MetaCyc: PWY-5872;MetaCyc: PWY-5856;MetaCyc: PWY-7233;MetaCyc: PWY-5855;MetaCyc: PWY-5870;MetaCyc: PWY-7230	"Ubiquinol-10 biosynthesis (prokaryotic)";"Ubiquinol-8 biosynthesis (prokaryotic)";"Ubiquinol-9 biosynthesis (eukaryotic)";"Ubiquinol-7 biosynthesis (eukaryotic)";"Ubiquinone and other terpenoid-quinone biosynthesis";"Ubiquinol biosynthesis";"Ubiquinol-10 biosynthesis (eukaryotic)";"Ubiquinol-9 biosynthesis (prokaryotic)";"Ubiquinol-6 bypass biosynthesis (eukaryotic)";"Ubiquinol-7 biosynthesis (prokaryotic)";"Ubiquinol-8 biosynthesis (eukaryotic)";"Ubiquinol-6 biosynthesis from 4-aminobenzoate (yeast)"
Medex_00084014-RA	1	Reactome: R-HSA-5689877	"Josephin domain DUBs"
Medex_00005372-RA	5	Reactome: R-HSA-2426168;Reactome: R-HSA-163765;Reactome: R-HSA-9029558;Reactome: R-HSA-75105;Reactome: R-HSA-199220	"Activation of gene expression by SREBF (SREBP)";"ChREBP activates metabolic gene expression";"NR1H2 & NR1H3 regulate gene expression linked to lipogenesis";"Fatty acyl-CoA biosynthesis";"Vitamin B5 (pantothenate) metabolism"
Medex_00070155-RA	2	Reactome: R-HSA-983168;Reactome: R-HSA-8951664	"Antigen processing: Ubiquitination & Proteasome degradation";"Neddylation"
Medex_00018158-RA	9	Reactome: R-HSA-73779;Reactome: R-HSA-167162;Reactome: R-HSA-76042;Reactome: R-HSA-6804756;Reactome: R-HSA-75953;Reactome: R-HSA-167161;Reactome: R-HSA-167172;Reactome: R-HSA-674695;Reactome: R-HSA-73776	"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Regulation of TP53 Activity through Phosphorylation";"RNA Polymerase II Transcription Initiation";"HIV Transcription Initiation";"Transcription of the HIV genome";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Promoter Escape"
Medex_00012253-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Medex_00054308-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00015008-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00085438-RA	13	Reactome: R-HSA-72689;Reactome: R-HSA-72764;Reactome: R-HSA-72706;Reactome: R-HSA-975956;Reactome: R-HSA-6791226;Reactome: R-HSA-2408557;Reactome: R-HSA-192823;Reactome: R-HSA-975957;Reactome: R-HSA-9633012;Reactome: R-HSA-156902;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-1799339	"Formation of a pool of free 40S subunits";"Eukaryotic Translation Termination";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"Selenocysteine synthesis";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"SRP-dependent cotranslational protein targeting to membrane"
Medex_00002621-RA	2	Reactome: R-HSA-8853383;KEGG: 00511+3.2.1.24	"Lysosomal oligosaccharide catabolism";"Other glycan degradation"
Medex_00011261-RA	2	Reactome: R-HSA-189085;KEGG: 00500+3.2.1.28	"Digestion of dietary carbohydrate";"Starch and sucrose metabolism"
Medex_00006436-RA	1	Reactome: R-HSA-429958	"mRNA decay by 3' to 5' exoribonuclease"
Medex_00093919-RA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Medex_00079439-RA	7	Reactome: R-HSA-76066;Reactome: R-HSA-73780;Reactome: R-HSA-749476;Reactome: R-HSA-1834949;Reactome: R-HSA-76061;Reactome: R-HSA-76071;Reactome: R-HSA-73980	"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Chain Elongation";"RNA Polymerase III Abortive And Retractive Initiation";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Transcription Termination"
Medex_00093522-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Medex_00079321-RA	2	Reactome: R-HSA-390471;Reactome: R-HSA-1660662	"Association of TriC/CCT with target proteins during biosynthesis";"Glycosphingolipid metabolism"
Medex_00048144-RA	1	Reactome: R-HSA-1474228	"Degradation of the extracellular matrix"
Medex_00013043-RA	1	Reactome: R-HSA-203927	"MicroRNA (miRNA) biogenesis"
Medex_00031203-RA	56	Reactome: R-HSA-9010553;Reactome: R-HSA-8939236;Reactome: R-HSA-382556;Reactome: R-HSA-68949;Reactome: R-HSA-211733;Reactome: R-HSA-4641258;Reactome: R-HSA-2467813;Reactome: R-HSA-180585;Reactome: R-HSA-450408;Reactome: R-HSA-9020702;Reactome: R-HSA-5658442;Reactome: R-HSA-8941858;Reactome: R-HSA-5358346;Reactome: R-HSA-983168;Reactome: R-HSA-202424;Reactome: R-HSA-5607761;Reactome: R-HSA-8852276;Reactome: R-HSA-5610780;Reactome: R-HSA-174178;Reactome: R-HSA-5632684;Reactome: R-HSA-349425;Reactome: R-HSA-1236978;Reactome: R-HSA-180534;Reactome: R-HSA-5689880;Reactome: R-HSA-5610785;Reactome: R-HSA-5689603;Reactome: R-HSA-5687128;Reactome: R-HSA-5668541;Reactome: R-HSA-4608870;Reactome: R-HSA-8939902;Reactome: R-HSA-75815;Reactome: R-HSA-195253;Reactome: R-HSA-5610783;Reactome: R-HSA-1236974;Reactome: R-HSA-8854050;Reactome: R-HSA-187577;Reactome: R-HSA-174084;Reactome: R-HSA-8951664;Reactome: R-HSA-2871837;Reactome: R-HSA-1169091;Reactome: R-HSA-174154;Reactome: R-HSA-5607764;Reactome: R-HSA-174184;Reactome: R-HSA-69017;Reactome: R-HSA-69601;Reactome: R-HSA-1234176;Reactome: R-HSA-5362768;Reactome: R-HSA-5676590;Reactome: R-HSA-8948751;Reactome: R-HSA-9604323;Reactome: R-HSA-68827;Reactome: R-HSA-5678895;Reactome: R-HSA-69481;Reactome: R-HSA-350562;Reactome: R-HSA-174113;Reactome: R-HSA-4641257	"Regulation of expression of SLITs and ROBOs";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"ABC-family proteins mediated transport";"Orc1 removal from chromatin";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Degradation of DVL";"Separation of Sister Chromatids";"Vif-mediated degradation of APOBEC3G";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Interleukin-1 signaling";"Regulation of RAS by GAPs";"Regulation of RUNX3 expression and activity";"Hedgehog ligand biogenesis";"Antigen processing: Ubiquitination & Proteasome degradation";"Downstream TCR signaling";"Dectin-1 mediated noncanonical NF-kB signaling";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Degradation of GLI1 by the proteasome";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Hedgehog 'on' state";"Autodegradation of the E3 ubiquitin ligase COP1";"Cross-presentation of soluble exogenous antigens (endosomes)";"Vpu mediated degradation of CD4";"Ub-specific processing proteases";"GLI3 is processed to GLI3R by the proteasome";"UCH proteinases";"MAPK6/MAPK4 signaling";"TNFR2 non-canonical NF-kB pathway";"Asymmetric localization of PCP proteins";"Regulation of RUNX2 expression and activity";"Ubiquitin-dependent degradation of Cyclin D";"Degradation of beta-catenin by the destruction complex";"Degradation of GLI2 by the proteasome";"ER-Phagosome pathway";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"SCF(Skp2)-mediated degradation of p27/p21";"Autodegradation of Cdh1 by Cdh1:APC/C";"Neddylation";"FCERI mediated NF-kB activation";"Activation of NF-kappaB in B cells";"APC/C:Cdc20 mediated degradation of Securin";"CLEC7A (Dectin-1) signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"CDK-mediated phosphorylation and removal of Cdc6";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"NIK-->noncanonical NF-kB signaling";"Regulation of PTEN stability and activity";"Negative regulation of NOTCH4 signaling";"CDT1 association with the CDC6:ORC:origin complex";"Defective CFTR causes cystic fibrosis";"G2/M Checkpoints";"Regulation of ornithine decarboxylase (ODC)";"SCF-beta-TrCP mediated degradation of Emi1";"Degradation of AXIN"
Medex_00045871-RA	4	Reactome: R-HSA-2206292;Reactome: R-HSA-2160916;Reactome: R-HSA-6798695;Reactome: R-HSA-2024096	"MPS VII - Sly syndrome";"Hyaluronan uptake and degradation";"Neutrophil degranulation";"HS-GAG degradation"
Medex_00027707-RA	1	Reactome: R-HSA-73943	"Reversal of alkylation damage by DNA dioxygenases"
Medex_00027777-RA	3	Reactome: R-HSA-191859;Reactome: R-HSA-3214858;Reactome: R-HSA-6804760	"snRNP Assembly";"RMTs methylate histone arginines";"Regulation of TP53 Activity through Methylation"
Medex_00037769-RA	16	Reactome: R-HSA-72702;Reactome: R-HSA-6791226;Reactome: R-HSA-72706;Reactome: R-HSA-975956;Reactome: R-HSA-72764;Reactome: R-HSA-1799339;Reactome: R-HSA-9633012;Reactome: R-HSA-975957;Reactome: R-HSA-2408557;Reactome: R-HSA-72689;Reactome: R-HSA-72649;Reactome: R-HSA-156902;Reactome: R-HSA-72695;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-192823	"Ribosomal scanning and start codon recognition";"Major pathway of rRNA processing in the nucleolus and cytosol";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"SRP-dependent cotranslational protein targeting to membrane";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Selenocysteine synthesis";"Formation of a pool of free 40S subunits";"Translation initiation complex formation";"Peptide chain elongation";"Formation of the ternary complex, and subsequently, the 43S complex";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Viral mRNA Translation"
Medex_00069996-RA	7	Reactome: R-HSA-390471;Reactome: R-HSA-6798695;Reactome: R-HSA-389957;Reactome: R-HSA-6814122;Reactome: R-HSA-389960;Reactome: R-HSA-5620922;Reactome: R-HSA-390450	"Association of TriC/CCT with target proteins during biosynthesis";"Neutrophil degranulation";"Prefoldin mediated transfer of substrate to CCT/TriC";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"Formation of tubulin folding intermediates by CCT/TriC";"BBSome-mediated cargo-targeting to cilium";"Folding of actin by CCT/TriC"
Medex_00003923-RA	3	Reactome: R-HSA-6787639;Reactome: R-HSA-5619078;Reactome: R-HSA-727802	"GDP-fucose biosynthesis";"Defective SLC35C1 causes congenital disorder of glycosylation 2C (CDG2C)";"Transport of nucleotide sugars"
Medex_00087856-RA	6	KEGG: 00260+5.4.2.11;MetaCyc: PWY-8004;KEGG: 00680+5.4.2.11;MetaCyc: PWY-5484;KEGG: 00010+5.4.2.11;MetaCyc: PWY-1622	"Glycine, serine and threonine metabolism";"Entner-Doudoroff pathway I";"Methane metabolism";"Glycolysis II (from fructose 6-phosphate)";"Glycolysis / Gluconeogenesis";"Formaldehyde assimilation I (serine pathway)"
Medex_00011891-RA	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
Medex_00087527-RA	2	KEGG: 00520+2.4.1.16;MetaCyc: PWY-6981	"Amino sugar and nucleotide sugar metabolism";"Chitin biosynthesis"
Medex_00077465-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Medex_00005597-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00062085-RA	6	MetaCyc: PWY-6908;MetaCyc: PWY-6907;MetaCyc: PWY-7356;KEGG: 00730+2.7.6.2;MetaCyc: PWY-6898;Reactome: R-HSA-196819	"Thiamine diphosphate biosynthesis IV (eukaryotes)";"Thiamine diphosphate biosynthesis III (Staphylococcus)";"Thiamine salvage IV (yeast)";"Thiamine metabolism";"Thiamine salvage III";"Vitamin B1 (thiamin) metabolism"
Medex_00023072-RA	1	Reactome: R-HSA-8850843	"Phosphate bond hydrolysis by NTPDase proteins"
Medex_00001150-RA	1	Reactome: R-HSA-376172	"DSCAM interactions"
Medex_00009628-RA	1	Reactome: R-HSA-6811436	"COPI-independent Golgi-to-ER retrograde traffic"
Medex_00045925-RA	7	Reactome: R-HSA-5628897;Reactome: R-HSA-380972;Reactome: R-HSA-165159;Reactome: R-HSA-1632852;Reactome: R-HSA-9639288;Reactome: R-HSA-8943724;Reactome: R-HSA-166208	"TP53 Regulates Metabolic Genes";"Energy dependent regulation of mTOR by LKB1-AMPK";"mTOR signalling";"Macroautophagy";"Amino acids regulate mTORC1";"Regulation of PTEN gene transcription";"mTORC1-mediated signalling"
Medex_00070359-RA	1	KEGG: 00970+6.3.5.7	"Aminoacyl-tRNA biosynthesis"
Medex_00053556-RA	13	MetaCyc: PWY-7721;MetaCyc: PWY-7182;MetaCyc: PWY-6859;MetaCyc: PWY-7141;MetaCyc: PWY-7659;MetaCyc: PWY-6383;KEGG: 00900+2.5.1.10+2.5.1.1;MetaCyc: PWY-7410;MetaCyc: PWY-7102;MetaCyc: PWY-5122;MetaCyc: PWY-5123;MetaCyc: PWY-7709;MetaCyc: PWY-7736	"Methyl phomopsenoate biosynthesis";"Linalool biosynthesis I";"All-trans-farnesol biosynthesis";"(3S)-linalool biosynthesis";"Viridicatumtoxin biosynthesis";"Mono-trans, poly-cis decaprenyl phosphate biosynthesis";"Terpenoid backbone biosynthesis";"Ipsdienol biosynthesis";"Bisabolene biosynthesis (engineered)";"Geranyl diphosphate biosynthesis";"Trans, trans-farnesyl diphosphate biosynthesis";"(3R)-linalool biosynthesis";"Stellatic acid biosynthesis"
Medex_00074978-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00047432-RA	6	Reactome: R-HSA-72702;Reactome: R-HSA-72649;Reactome: R-HSA-156827;Reactome: R-HSA-72695;Reactome: R-HSA-72706;Reactome: R-HSA-72689	"Ribosomal scanning and start codon recognition";"Translation initiation complex formation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Formation of the ternary complex, and subsequently, the 43S complex";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Formation of a pool of free 40S subunits"
Medex_00027936-RA	1	Reactome: R-HSA-211945	"Phase I - Functionalization of compounds"
Medex_00004020-RA	5	MetaCyc: PWY-7791;MetaCyc: PWY-7790;MetaCyc: PWY-5686;Reactome: R-HSA-500753;KEGG: 00240+4.1.1.23	"UMP biosynthesis III";"UMP biosynthesis II";"UMP biosynthesis I";"Pyrimidine biosynthesis";"Pyrimidine metabolism"
Medex_00064822-RA	8	Reactome: R-HSA-77387;Reactome: R-HSA-983712;Reactome: R-HSA-1222556;Reactome: R-HSA-9639288;Reactome: R-HSA-917977;KEGG: 00195+7.1.2.2;KEGG: 00190+7.1.2.2;MetaCyc: PWY-7980	"Insulin receptor recycling";"Ion channel transport";"ROS and RNS production in phagocytes";"Amino acids regulate mTORC1";"Transferrin endocytosis and recycling";"Photosynthesis";"Oxidative phosphorylation";"ATP biosynthesis"
Medex_00084186-RA	3	KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway"
Medex_00022823-RA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Medex_00082536-RA	1	Reactome: R-HSA-975957	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
Medex_00045921-RA	8	Reactome: R-HSA-71336;KEGG: 00710+5.3.1.6;Reactome: R-HSA-5659996;KEGG: 00051+5.3.1.6;MetaCyc: PWY-5723;Reactome: R-HSA-6791461;KEGG: 00030+5.3.1.6;MetaCyc: PWY-1861	"Pentose phosphate pathway";"Carbon fixation in photosynthetic organisms";"RPIA deficiency: failed conversion of R5P to RU5P";"Fructose and mannose metabolism";"Rubisco shunt";"RPIA deficiency: failed conversion of RU5P to R5P";"Pentose phosphate pathway";"Formaldehyde assimilation II (assimilatory RuMP Cycle)"
Medex_00088284-RA	2	Reactome: R-HSA-1660662;Reactome: R-HSA-390471	"Glycosphingolipid metabolism";"Association of TriC/CCT with target proteins during biosynthesis"
Medex_00089304-RA	3	Reactome: R-HSA-3214847;Reactome: R-HSA-201722;Reactome: R-HSA-5689880	"HATs acetylate histones";"Formation of the beta-catenin:TCF transactivating complex";"Ub-specific processing proteases"
Medex_00004972-RA	1	Reactome: R-HSA-426117	"Cation-coupled Chloride cotransporters"
Medex_00036954-RA	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00039018-RA	4	KEGG: 00970+6.1.1.15;Reactome: R-HSA-2408522;Reactome: R-HSA-6782315;Reactome: R-HSA-379716	"Aminoacyl-tRNA biosynthesis";"Selenoamino acid metabolism";"tRNA modification in the nucleus and cytosol";"Cytosolic tRNA aminoacylation"
Medex_00076317-RA	1	Reactome: R-HSA-9022692	"Regulation of MECP2 expression and activity"
Medex_00086346-RA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00046239-RA	1	Reactome: R-HSA-2559584	"Formation of Senescence-Associated Heterochromatin Foci (SAHF)"
Medex_00073157-RA	5	KEGG: 00190+7.1.1.8;MetaCyc: PWY-7082;MetaCyc: PWY-7279;MetaCyc: PWY-6692;MetaCyc: PWY-3781	"Oxidative phosphorylation";"Ammonia oxidation IV (autotrophic ammonia oxidizers)";"Aerobic respiration II (cytochrome c) (yeast)";"Fe(II) oxidation";"Aerobic respiration I (cytochrome c)"
Medex_00079424-RA	1	Reactome: R-HSA-110357	"Displacement of DNA glycosylase by APEX1"
Medex_00055714-RA	2	MetaCyc: PWY-6281;KEGG: 00970+6.1.1.11	"L-selenocysteine biosynthesis II (archaea and eukaryotes)";"Aminoacyl-tRNA biosynthesis"
Medex_00008115-RA	12	MetaCyc: PWY-5537;MetaCyc: PWY-6728;MetaCyc: PWY-5913;MetaCyc: PWY-6969;KEGG: 00660+6.2.1.5;MetaCyc: PWY-5690;MetaCyc: PWY-7384;KEGG: 00720+6.2.1.5;MetaCyc: PWY-5392;KEGG: 00640+6.2.1.5;KEGG: 00020+6.2.1.5;MetaCyc: PWY-5538	"Pyruvate fermentation to acetate V";"Methylaspartate cycle";"Partial TCA cycle (obligate autotrophs)";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"C5-Branched dibasic acid metabolism";"TCA cycle II (plants and fungi)";"Anaerobic energy metabolism (invertebrates, mitochondrial)";"Carbon fixation pathways in prokaryotes";"Reductive TCA cycle II";"Propanoate metabolism";"Citrate cycle (TCA cycle)";"Pyruvate fermentation to acetate VI"
Medex_00002897-RA	3	KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway"
Medex_00037536-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00045874-RA	4	MetaCyc: PWY-7219;KEGG: 00250+6.3.4.4;KEGG: 00230+6.3.4.4;Reactome: R-HSA-73817	"Adenosine ribonucleotides de novo biosynthesis";"Alanine, aspartate and glutamate metabolism";"Purine metabolism";"Purine ribonucleoside monophosphate biosynthesis"
Medex_00012942-RA	1	Reactome: R-HSA-2132295	"MHC class II antigen presentation"
Medex_00019148-RA	2	MetaCyc: PWY-7221;KEGG: 00230+2.7.4.8	"Guanosine ribonucleotides de novo biosynthesis";"Purine metabolism"
Medex_00061655-RA	16	Reactome: R-HSA-1799339;Reactome: R-HSA-9633012;Reactome: R-HSA-975957;Reactome: R-HSA-72702;Reactome: R-HSA-6791226;Reactome: R-HSA-975956;Reactome: R-HSA-72706;Reactome: R-HSA-72764;Reactome: R-HSA-72649;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-72695;Reactome: R-HSA-156902;Reactome: R-HSA-192823;Reactome: R-HSA-2408557;Reactome: R-HSA-72689	"SRP-dependent cotranslational protein targeting to membrane";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Ribosomal scanning and start codon recognition";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Eukaryotic Translation Termination";"Translation initiation complex formation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Formation of the ternary complex, and subsequently, the 43S complex";"Peptide chain elongation";"Viral mRNA Translation";"Selenocysteine synthesis";"Formation of a pool of free 40S subunits"
Medex_00006345-RA	1	Reactome: R-HSA-163560	"Triglyceride catabolism"
Medex_00052317-RA	2	Reactome: R-HSA-611105;Reactome: R-HSA-8876725	"Respiratory electron transport";"Protein methylation"
Medex_00051501-RA	2	Reactome: R-HSA-3214847;Reactome: R-HSA-6804758	"HATs acetylate histones";"Regulation of TP53 Activity through Acetylation"
Medex_00032161-RA	5	Reactome: R-HSA-390471;Reactome: R-HSA-6814122;Reactome: R-HSA-389957;Reactome: R-HSA-390450;Reactome: R-HSA-389960	"Association of TriC/CCT with target proteins during biosynthesis";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"Prefoldin mediated transfer of substrate to CCT/TriC";"Folding of actin by CCT/TriC";"Formation of tubulin folding intermediates by CCT/TriC"
Medex_00082896-RA	2	Reactome: R-HSA-975577;Reactome: R-HSA-2022854	"N-Glycan antennae elongation";"Keratan sulfate biosynthesis"
Medex_00062225-RA	2	Reactome: R-HSA-8949613;Reactome: R-HSA-163210	"Cristae formation";"Formation of ATP by chemiosmotic coupling"
Medex_00020993-RA	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
Medex_00062753-RA	14	MetaCyc: PWY-7724;MetaCyc: PWY-7601;MetaCyc: PWY-7725;KEGG: 00062+2.3.1.199;MetaCyc: PWY-6598;MetaCyc: PWY-5080;MetaCyc: PWY-8041;MetaCyc: PWY-6433;MetaCyc: PWY-7619;MetaCyc: PWY-7602;MetaCyc: PWY-7036;MetaCyc: PWY-7035;Reactome: R-HSA-75876;MetaCyc: PWY-5972	"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Fatty acid elongation";"Sciadonate biosynthesis";"Very long chain fatty acid biosynthesis I";"Ultra-long-chain fatty acid biosynthesis";"Hydroxylated fatty acid biosynthesis (plants)";"Juniperonate biosynthesis";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis II";"(9Z)-tricosene biosynthesis";"Synthesis of very long-chain fatty acyl-CoAs";"Stearate biosynthesis I (animals)"
Medex_00061620-RA	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
Medex_00062869-RA	1	Reactome: R-HSA-419771	"Opsins"
Medex_00040256-RA	5	Reactome: R-HSA-917977;Reactome: R-HSA-1222556;Reactome: R-HSA-9639288;Reactome: R-HSA-77387;Reactome: R-HSA-983712	"Transferrin endocytosis and recycling";"ROS and RNS production in phagocytes";"Amino acids regulate mTORC1";"Insulin receptor recycling";"Ion channel transport"
Medex_00066020-RA	5	Reactome: R-HSA-1912399;Reactome: R-HSA-5083630;Reactome: R-HSA-1912408;Reactome: R-HSA-350054;Reactome: R-HSA-1912420	"Pre-NOTCH Processing in the Endoplasmic Reticulum";"Defective LFNG causes SCDO3";"Pre-NOTCH Transcription and Translation";"Notch-HLH transcription pathway";"Pre-NOTCH Processing in Golgi"
Medex_00047614-RA	3	Reactome: R-HSA-933542;Reactome: R-HSA-445989;Reactome: R-HSA-1810476	"TRAF6 mediated NF-kB activation";"TAK1 activates NFkB by phosphorylation and activation of IKKs complex";"RIP-mediated NFkB activation via ZBP1"
Medex_00019593-RA	1	Reactome: R-HSA-380320	"Recruitment of NuMA to mitotic centrosomes"
Medex_00080410-RA	2	Reactome: R-HSA-3214847;Reactome: R-HSA-171319	"HATs acetylate histones";"Telomere Extension By Telomerase"
Medex_00013133-RA	2	Reactome: R-HSA-8876198;Reactome: R-HSA-204005	"RAB GEFs exchange GTP for GDP on RABs";"COPII-mediated vesicle transport"
Medex_00063294-RA	6	KEGG: 00511+3.2.1.23;KEGG: 00600+3.2.1.23;MetaCyc: PWY-6807;KEGG: 00604+3.2.1.23;KEGG: 00052+3.2.1.23;KEGG: 00531+3.2.1.23	"Other glycan degradation";"Sphingolipid metabolism";"Xyloglucan degradation II (exoglucanase)";"Glycosphingolipid biosynthesis - ganglio series";"Galactose metabolism";"Glycosaminoglycan degradation"
Medex_00077812-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Medex_00059442-RA	2	MetaCyc: PWY-4261;KEGG: 00561+2.7.1.30	"Glycerol degradation I";"Glycerolipid metabolism"
Medex_00017379-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Medex_00010787-RA	2	KEGG: 00051+2.7.1.105+3.1.3.46;Reactome: R-HSA-9634600	"Fructose and mannose metabolism";"Regulation of glycolysis by fructose 2,6-bisphosphate metabolism"
Medex_00070780-RA	1	Reactome: R-HSA-418594	"G alpha (i) signalling events"
Medex_00032865-RA	6	KEGG: 00930+3.1.1.17;KEGG: 00053+3.1.1.17;MetaCyc: PWY-7165;MetaCyc: PWY-5530;KEGG: 00030+3.1.1.17;MetaCyc: PWY-2221	"Caprolactam degradation";"Ascorbate and aldarate metabolism";"L-ascorbate biosynthesis VI (engineered pathway)";"Sorbitol biosynthesis II";"Pentose phosphate pathway";"Entner-Doudoroff pathway III (semi-phosphorylative)"
Medex_00101724-RA	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
Medex_00070676-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Medex_00002581-RA	2	KEGG: 00260+1.4.4.2;Reactome: R-HSA-6783984	"Glycine, serine and threonine metabolism";"Glycine degradation"
Medex_00048102-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Medex_00011982-RA	5	KEGG: 00561+3.2.1.22;MetaCyc: PWY-6527;KEGG: 00052+3.2.1.22;KEGG: 00600+3.2.1.22;KEGG: 00603+3.2.1.22	"Glycerolipid metabolism";"Stachyose degradation";"Galactose metabolism";"Sphingolipid metabolism";"Glycosphingolipid biosynthesis - globo and isoglobo series"
Medex_00083493-RA	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
Medex_00016938-RA	1	Reactome: R-HSA-432722	"Golgi Associated Vesicle Biogenesis"
Medex_00060671-RA	2	Reactome: R-HSA-6798695;Reactome: R-HSA-8964038	"Neutrophil degranulation";"LDL clearance"
Medex_00035547-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00076335-RA	7	Reactome: R-HSA-8854214;Reactome: R-HSA-5674400;Reactome: R-HSA-5628897;Reactome: R-HSA-380972;Reactome: R-HSA-1632852;Reactome: R-HSA-198323;Reactome: R-HSA-165181	"TBC/RABGAPs";"Constitutive Signaling by AKT1 E17K in Cancer";"TP53 Regulates Metabolic Genes";"Energy dependent regulation of mTOR by LKB1-AMPK";"Macroautophagy";"AKT phosphorylates targets in the cytosol";"Inhibition of TSC complex formation by PKB"
Medex_00067301-RA	2	KEGG: 00240+4.2.1.70;MetaCyc: PWY-6019	"Pyrimidine metabolism";"Pseudouridine degradation"
Medex_00092987-RA	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
Medex_00045739-RA	1	Reactome: R-HSA-3214858	"RMTs methylate histone arginines"
Medex_00045918-RA	8	Reactome: R-HSA-6791461;KEGG: 00030+5.3.1.6;MetaCyc: PWY-1861;Reactome: R-HSA-71336;KEGG: 00710+5.3.1.6;Reactome: R-HSA-5659996;KEGG: 00051+5.3.1.6;MetaCyc: PWY-5723	"RPIA deficiency: failed conversion of RU5P to R5P";"Pentose phosphate pathway";"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"Pentose phosphate pathway";"Carbon fixation in photosynthetic organisms";"RPIA deficiency: failed conversion of R5P to RU5P";"Fructose and mannose metabolism";"Rubisco shunt"
Medex_00023545-RA	1	Reactome: R-HSA-3214858	"RMTs methylate histone arginines"
Medex_00050991-RA	1	Reactome: R-HSA-6806664	"Metabolism of vitamin K"
Medex_00005471-RA	2	Reactome: R-HSA-8853383;KEGG: 00511+3.2.1.24	"Lysosomal oligosaccharide catabolism";"Other glycan degradation"
Medex_00056586-RA	3	Reactome: R-HSA-72187;Reactome: R-HSA-73856;Reactome: R-HSA-159236	"mRNA 3'-end processing";"RNA Polymerase II Transcription Termination";"Transport of Mature mRNA derived from an Intron-Containing Transcript"
Medex_00046263-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00062131-RA	10	MetaCyc: PWY-7198;Reactome: R-HSA-499943;Reactome: R-HSA-69205;MetaCyc: PWY-3841;MetaCyc: PWY-7184;MetaCyc: PWY-7187;KEGG: 00240+2.1.1.45;MetaCyc: PWY-7210;MetaCyc: PWY-7199;KEGG: 00670+2.1.1.45	"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Interconversion of nucleotide di- and triphosphates";"G1/S-Specific Transcription";"Folate transformations II (plants)";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Pyrimidine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine metabolism";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Pyrimidine deoxyribonucleosides salvage";"One carbon pool by folate"
Medex_00079801-RA	2	Reactome: R-HSA-442982;Reactome: R-HSA-5673001	"Ras activation upon Ca2+ influx through NMDA receptor";"RAF/MAP kinase cascade"
Medex_00004305-RA	4	KEGG: 00520+3.2.1.14;MetaCyc: PWY-6855;MetaCyc: PWY-7822;MetaCyc: PWY-6902	"Amino sugar and nucleotide sugar metabolism";"Chitin degradation I (archaea)";"Chitin degradation III (Serratia)";"Chitin degradation II (Vibrio)"
Medex_00014275-RA	1	Reactome: R-HSA-70350	"Fructose catabolism"
Medex_00009153-RA	57	Reactome: R-HSA-174178;Reactome: R-HSA-5607761;Reactome: R-HSA-5610780;Reactome: R-HSA-8852276;Reactome: R-HSA-1236978;Reactome: R-HSA-349425;Reactome: R-HSA-180534;Reactome: R-HSA-5632684;Reactome: R-HSA-5668541;Reactome: R-HSA-5689603;Reactome: R-HSA-5687128;Reactome: R-HSA-4608870;Reactome: R-HSA-5689880;Reactome: R-HSA-5610785;Reactome: R-HSA-195253;Reactome: R-HSA-8939902;Reactome: R-HSA-75815;Reactome: R-HSA-9010553;Reactome: R-HSA-382556;Reactome: R-HSA-211733;Reactome: R-HSA-8939236;Reactome: R-HSA-68949;Reactome: R-HSA-180585;Reactome: R-HSA-450408;Reactome: R-HSA-4641258;Reactome: R-HSA-2467813;Reactome: R-HSA-6798695;Reactome: R-HSA-9020702;Reactome: R-HSA-983168;Reactome: R-HSA-202424;Reactome: R-HSA-5658442;Reactome: R-HSA-5358346;Reactome: R-HSA-8941858;Reactome: R-HSA-8951664;Reactome: R-HSA-2871837;Reactome: R-HSA-174184;Reactome: R-HSA-5607764;Reactome: R-HSA-1169091;Reactome: R-HSA-174154;Reactome: R-HSA-68827;Reactome: R-HSA-8948751;Reactome: R-HSA-9604323;Reactome: R-HSA-69017;Reactome: R-HSA-5362768;Reactome: R-HSA-1234176;Reactome: R-HSA-69601;Reactome: R-HSA-5676590;Reactome: R-HSA-174113;Reactome: R-HSA-4641257;Reactome: R-HSA-5678895;Reactome: R-HSA-350562;Reactome: R-HSA-69481;Reactome: R-HSA-1236974;Reactome: R-HSA-8854050;Reactome: R-HSA-5610783;Reactome: R-HSA-187577;Reactome: R-HSA-174084	"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Dectin-1 mediated noncanonical NF-kB signaling";"Degradation of GLI1 by the proteasome";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Cross-presentation of soluble exogenous antigens (endosomes)";"Autodegradation of the E3 ubiquitin ligase COP1";"Vpu mediated degradation of CD4";"Hedgehog 'on' state";"TNFR2 non-canonical NF-kB pathway";"UCH proteinases";"MAPK6/MAPK4 signaling";"Asymmetric localization of PCP proteins";"Ub-specific processing proteases";"GLI3 is processed to GLI3R by the proteasome";"Degradation of beta-catenin by the destruction complex";"Regulation of RUNX2 expression and activity";"Ubiquitin-dependent degradation of Cyclin D";"Regulation of expression of SLITs and ROBOs";"ABC-family proteins mediated transport";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Orc1 removal from chromatin";"Vif-mediated degradation of APOBEC3G";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Degradation of DVL";"Separation of Sister Chromatids";"Neutrophil degranulation";"Interleukin-1 signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Downstream TCR signaling";"Regulation of RAS by GAPs";"Hedgehog ligand biogenesis";"Regulation of RUNX3 expression and activity";"Neddylation";"FCERI mediated NF-kB activation";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"CLEC7A (Dectin-1) signaling";"Activation of NF-kappaB in B cells";"APC/C:Cdc20 mediated degradation of Securin";"CDT1 association with the CDC6:ORC:origin complex";"Regulation of PTEN stability and activity";"Negative regulation of NOTCH4 signaling";"CDK-mediated phosphorylation and removal of Cdc6";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"NIK-->noncanonical NF-kB signaling";"SCF-beta-TrCP mediated degradation of Emi1";"Degradation of AXIN";"Defective CFTR causes cystic fibrosis";"Regulation of ornithine decarboxylase (ODC)";"G2/M Checkpoints";"ER-Phagosome pathway";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Degradation of GLI2 by the proteasome";"SCF(Skp2)-mediated degradation of p27/p21";"Autodegradation of Cdh1 by Cdh1:APC/C"
Medex_00101158-RA	1	Reactome: R-HSA-176974	"Unwinding of DNA"
Medex_00060381-RA	14	Reactome: R-HSA-5687128;Reactome: R-HSA-8934593;Reactome: R-HSA-8986944;Reactome: R-HSA-426496;Reactome: R-HSA-203927;Reactome: R-HSA-5628897;Reactome: R-HSA-9018519;Reactome: R-HSA-1912408;Reactome: R-HSA-426486;Reactome: R-HSA-9022692;Reactome: R-HSA-9029569;Reactome: R-HSA-4086398;Reactome: R-HSA-8948700;Reactome: R-HSA-8943723	"MAPK6/MAPK4 signaling";"Regulation of RUNX1 Expression and Activity";"Transcriptional Regulation by MECP2";"Post-transcriptional silencing by small RNAs";"MicroRNA (miRNA) biogenesis";"TP53 Regulates Metabolic Genes";"Estrogen-dependent gene expression";"Pre-NOTCH Transcription and Translation";"Small interfering RNA (siRNA) biogenesis";"Regulation of MECP2 expression and activity";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Ca2+ pathway";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"Regulation of PTEN mRNA translation"
Medex_00034047-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00059077-RA	4	KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;Reactome: R-HSA-180024	"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"DARPP-32 events"
Medex_00029927-RA	1	Reactome: R-HSA-5663220	"RHO GTPases Activate Formins"
Medex_00064737-RA	2	Reactome: R-HSA-5689880;Reactome: R-HSA-156581	"Ub-specific processing proteases";"Methylation"
Medex_00031556-RA	2	Reactome: R-HSA-72706;Reactome: R-HSA-72702	"GTP hydrolysis and joining of the 60S ribosomal subunit";"Ribosomal scanning and start codon recognition"
Medex_00063249-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00008898-RA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
Medex_00011531-RA	5	KEGG: 00565+2.5.1.26;MetaCyc: PWY-7782;Reactome: R-HSA-75896;Reactome: R-HSA-9033241;Reactome: R-HSA-9033500	"Ether lipid metabolism";"Plasmalogen biosynthesis";"Plasmalogen biosynthesis";"Peroxisomal protein import";"TYSND1 cleaves peroxisomal proteins"
Medex_00007474-RA	7	MetaCyc: PWY-5461;MetaCyc: PWY-6824;MetaCyc: PWY-5469;MetaCyc: PWY-7214;MetaCyc: PWY-5466;MetaCyc: PWY-7445;KEGG: 00940+1.11.1.7	"Betanidin degradation";"Justicidin B biosynthesis";"Sesamin biosynthesis";"Baicalein degradation (hydrogen peroxide detoxification)";"Matairesinol biosynthesis";"Luteolin triglucuronide degradation";"Phenylpropanoid biosynthesis"
Medex_00068959-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00059345-RA	3	Reactome: R-HSA-73856;Reactome: R-HSA-72187;Reactome: R-HSA-159236	"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing";"Transport of Mature mRNA derived from an Intron-Containing Transcript"
Medex_00042089-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Medex_00003860-RA	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
Medex_00087916-RA	6	Reactome: R-HSA-110357;Reactome: R-HSA-110362;Reactome: R-HSA-110373;Reactome: R-HSA-73930;Reactome: R-HSA-73933;Reactome: R-HSA-5651801	"Displacement of DNA glycosylase by APEX1";"POLB-Dependent Long Patch Base Excision Repair";"Resolution of AP sites via the multiple-nucleotide patch replacement pathway";"Abasic sugar-phosphate removal via the single-nucleotide replacement pathway";"Resolution of Abasic Sites (AP sites)";"PCNA-Dependent Long Patch Base Excision Repair"
Medex_00016268-RA	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
Medex_00000452-RA	2	Reactome: R-HSA-389661;Reactome: R-HSA-9033241	"Glyoxylate metabolism and glycine degradation";"Peroxisomal protein import"
Medex_00047645-RA	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
Medex_00031688-RA	6	Reactome: R-HSA-68867;Reactome: R-HSA-68949;Reactome: R-HSA-69052;Reactome: R-HSA-176187;Reactome: R-HSA-68962;Reactome: R-HSA-176974	"Assembly of the pre-replicative complex";"Orc1 removal from chromatin";"Switching of origins to a post-replicative state";"Activation of ATR in response to replication stress";"Activation of the pre-replicative complex";"Unwinding of DNA"
Medex_00093267-RA	4	KEGG: 00030+1.1.1.49;MetaCyc: PWY-7268;MetaCyc: PWY-8004;KEGG: 00480+1.1.1.49	"Pentose phosphate pathway";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"Entner-Doudoroff pathway I";"Glutathione metabolism"
Medex_00059612-RA	1	Reactome: R-HSA-1614517	"Sulfide oxidation to sulfate"
Medex_00044274-RA	2	Reactome: R-HSA-983231;Reactome: R-HSA-383280	"Factors involved in megakaryocyte development and platelet production";"Nuclear Receptor transcription pathway"
Medex_00041484-RA	1	Reactome: R-HSA-5666185	"RHO GTPases Activate Rhotekin and Rhophilins"
Medex_00007115-RA	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
Medex_00074686-RA	1	Reactome: R-HSA-2564830	"Cytosolic iron-sulfur cluster assembly"
Medex_00005368-RA	6	KEGG: 00531+3.2.1.23;KEGG: 00052+3.2.1.23;KEGG: 00604+3.2.1.23;MetaCyc: PWY-6807;KEGG: 00600+3.2.1.23;KEGG: 00511+3.2.1.23	"Glycosaminoglycan degradation";"Galactose metabolism";"Glycosphingolipid biosynthesis - ganglio series";"Xyloglucan degradation II (exoglucanase)";"Sphingolipid metabolism";"Other glycan degradation"
Medex_00018162-RA	9	Reactome: R-HSA-6804756;Reactome: R-HSA-76042;Reactome: R-HSA-167162;Reactome: R-HSA-73779;Reactome: R-HSA-73776;Reactome: R-HSA-674695;Reactome: R-HSA-167172;Reactome: R-HSA-75953;Reactome: R-HSA-167161	"Regulation of TP53 Activity through Phosphorylation";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Pre-transcription Events";"Transcription of the HIV genome";"RNA Polymerase II Transcription Initiation";"HIV Transcription Initiation"
Medex_00019649-RA	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
Medex_00044510-RA	1	Reactome: R-HSA-977347	"Serine biosynthesis"
Medex_00035186-RA	13	Reactome: R-HSA-2214320;Reactome: R-HSA-3000157;Reactome: R-HSA-419037;Reactome: R-HSA-1474244;Reactome: R-HSA-3000178;Reactome: R-HSA-186797;Reactome: R-HSA-3000171;Reactome: R-HSA-1650814;Reactome: R-HSA-1442490;Reactome: R-HSA-2243919;Reactome: R-HSA-216083;Reactome: R-HSA-8948216;Reactome: R-HSA-2022090	"Anchoring fibril formation";"Laminin interactions";"NCAM1 interactions";"Extracellular matrix organization";"ECM proteoglycans";"Signaling by PDGF";"Non-integrin membrane-ECM interactions";"Collagen biosynthesis and modifying enzymes";"Collagen degradation";"Crosslinking of collagen fibrils";"Integrin cell surface interactions";"Collagen chain trimerization";"Assembly of collagen fibrils and other multimeric structures"
Medex_00018560-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Medex_00016152-RA	1	Reactome: R-HSA-8951664	"Neddylation"
Medex_00033663-RA	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
Medex_00011184-RA	6	Reactome: R-HSA-72649;Reactome: R-HSA-72702;Reactome: R-HSA-72695;Reactome: R-HSA-156827;Reactome: R-HSA-72706;Reactome: R-HSA-72689	"Translation initiation complex formation";"Ribosomal scanning and start codon recognition";"Formation of the ternary complex, and subsequently, the 43S complex";"L13a-mediated translational silencing of Ceruloplasmin expression";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Formation of a pool of free 40S subunits"
Medex_00073939-RA	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
Medex_00000285-RA	2	Reactome: R-HSA-611105;Reactome: R-HSA-5628897	"Respiratory electron transport";"TP53 Regulates Metabolic Genes"
Medex_00019720-RA	15	Reactome: R-HSA-167290;Reactome: R-HSA-167158;Reactome: R-HSA-167242;Reactome: R-HSA-167152;Reactome: R-HSA-674695;Reactome: R-HSA-6807505;Reactome: R-HSA-167243;Reactome: R-HSA-113418;Reactome: R-HSA-167287;Reactome: R-HSA-75955;Reactome: R-HSA-6796648;Reactome: R-HSA-167238;Reactome: R-HSA-112382;Reactome: R-HSA-167246;Reactome: R-HSA-167200	"Pausing and recovery of HIV elongation";"Formation of the HIV-1 Early Elongation Complex";"Abortive elongation of HIV-1 transcript in the absence of Tat";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Polymerase II Pre-transcription Events";"RNA polymerase II transcribes snRNA genes";"Tat-mediated HIV elongation arrest and recovery";"Formation of the Early Elongation Complex";"HIV elongation arrest and recovery";"RNA Polymerase II Transcription Elongation";"TP53 Regulates Transcription of DNA Repair Genes";"Pausing and recovery of Tat-mediated HIV elongation";"Formation of RNA Pol II elongation complex";"Tat-mediated elongation of the HIV-1 transcript";"Formation of HIV-1 elongation complex containing HIV-1 Tat"
Medex_00022739-RA	3	KEGG: 00260+2.1.2.10;Reactome: R-HSA-6783984;KEGG: 00670+2.1.2.10	"Glycine, serine and threonine metabolism";"Glycine degradation";"One carbon pool by folate"
Medex_00018004-RA	2	Reactome: R-HSA-5693568;Reactome: R-HSA-6783310	"Resolution of D-loop Structures through Holliday Junction Intermediates";"Fanconi Anemia Pathway"
Medex_00029290-RA	1	Reactome: R-HSA-425381	"Bicarbonate transporters"
Medex_00044589-RA	2	Reactome: R-HSA-381340;Reactome: R-HSA-1989781	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression"
Medex_00089839-RA	4	Reactome: R-HSA-975871;Reactome: R-HSA-6799198;Reactome: R-HSA-166058;Reactome: R-HSA-975138	"MyD88 cascade initiated on plasma membrane";"Complex I biogenesis";"MyD88:MAL(TIRAP) cascade initiated on plasma membrane";"TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation"
Medex_00029457-RA	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00029254-RA	4	Reactome: R-HSA-70895;KEGG: 00640+1.2.1.27;KEGG: 00280+1.2.1.27;MetaCyc: PWY-5642	"Branched-chain amino acid catabolism";"Propanoate metabolism";"Valine, leucine and isoleucine degradation";"2,4-dinitrotoluene degradation"
Medex_00077361-RA	2	MetaCyc: PWY-6558;Reactome: R-HSA-2022928	"Heparan sulfate biosynthesis (late stages)";"HS-GAG biosynthesis"
Medex_00030532-RA	2	Reactome: R-HSA-5357956;Reactome: R-HSA-5357905	"TNFR1-induced NFkappaB signaling pathway";"Regulation of TNFR1 signaling"
Medex_00040507-RA	1	Reactome: R-HSA-196108	"Pregnenolone biosynthesis"
Medex_00016943-RA	1	Reactome: R-HSA-432722	"Golgi Associated Vesicle Biogenesis"
Medex_00078452-RA	1	Reactome: R-HSA-1799339	"SRP-dependent cotranslational protein targeting to membrane"
Medex_00050880-RA	33	Reactome: R-HSA-6781823;Reactome: R-HSA-167172;Reactome: R-HSA-69202;Reactome: R-HSA-75955;Reactome: R-HSA-6782135;Reactome: R-HSA-167160;Reactome: R-HSA-167246;Reactome: R-HSA-167200;Reactome: R-HSA-75953;Reactome: R-HSA-167161;Reactome: R-HSA-69231;Reactome: R-HSA-113418;Reactome: R-HSA-112382;Reactome: R-HSA-73779;Reactome: R-HSA-73772;Reactome: R-HSA-6782210;Reactome: R-HSA-167152;Reactome: R-HSA-674695;Reactome: R-HSA-8939236;Reactome: R-HSA-73776;Reactome: R-HSA-73863;Reactome: R-HSA-167162;Reactome: R-HSA-76042;Reactome: R-HSA-69656;Reactome: R-HSA-69273;Reactome: R-HSA-6781827;Reactome: R-HSA-5696395;Reactome: R-HSA-167158;Reactome: R-HSA-73762;Reactome: R-HSA-6796648;Reactome: R-HSA-72086;Reactome: R-HSA-427413;Reactome: R-HSA-77075	"Formation of TC-NER Pre-Incision Complex";"Transcription of the HIV genome";"Cyclin E associated events during G1/S transition";"RNA Polymerase II Transcription Elongation";"Dual incision in TC-NER";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Tat-mediated elongation of the HIV-1 transcript";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Polymerase II Transcription Initiation";"HIV Transcription Initiation";"Cyclin D associated events in G1";"Formation of the Early Elongation Complex";"Formation of RNA Pol II elongation complex";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase I Promoter Escape";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Polymerase II Pre-transcription Events";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"RNA Polymerase II Promoter Escape";"RNA Polymerase I Transcription Termination";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Cyclin A:Cdk2-associated events at S phase entry";"Cyclin A/B1/B2 associated events during G2/M transition";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Formation of Incision Complex in GG-NER";"Formation of the HIV-1 Early Elongation Complex";"RNA Polymerase I Transcription Initiation";"TP53 Regulates Transcription of DNA Repair Genes";"mRNA Capping";"NoRC negatively regulates rRNA expression";"RNA Pol II CTD phosphorylation and interaction with CE"
Medex_00051045-RA	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5419276;Reactome: R-HSA-5368286	"Mitochondrial translation elongation";"Mitochondrial translation termination";"Mitochondrial translation initiation"
Medex_00031326-RA	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5419276;Reactome: R-HSA-5368286	"Mitochondrial translation elongation";"Mitochondrial translation termination";"Mitochondrial translation initiation"
Medex_00017778-RA	14	Reactome: R-HSA-977225;Reactome: R-HSA-9013507;Reactome: R-HSA-2122948;Reactome: R-HSA-9017802;Reactome: R-HSA-2894862;Reactome: R-HSA-6798695;Reactome: R-HSA-1251985;Reactome: R-HSA-3928665;Reactome: R-HSA-2644606;Reactome: R-HSA-2979096;Reactome: R-HSA-9013700;Reactome: R-HSA-1474228;Reactome: R-HSA-193692;Reactome: R-HSA-205043	"Amyloid fiber formation";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Activated NOTCH1 Transmits Signal to the Nucleus";"Noncanonical activation of NOTCH3";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Neutrophil degranulation";"Nuclear signaling by ERBB4";"EPH-ephrin mediated repulsion of cells";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"NOTCH4 Activation and Transmission of Signal to the Nucleus";"Degradation of the extracellular matrix";"Regulated proteolysis of p75NTR";"NRIF signals cell death from the nucleus"
Medex_00040462-RA	6	MetaCyc: PWY-7433;Reactome: R-HSA-913709;KEGG: 00512+2.4.1.122;MetaCyc: PWY-7290;Reactome: R-HSA-5083632;KEGG: 00514+2.4.1.122	"Mucin core 1 and core 2 O-glycosylation";"O-linked glycosylation of mucins";"Mucin type O-glycan biosynthesis";"Escherichia coli serotype O86 O-antigen biosynthesis";"Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)";"Other types of O-glycan biosynthesis"
Medex_00013773-RA	2	Reactome: R-HSA-425561;Reactome: R-HSA-5619055	"Sodium/Calcium exchangers";"Defective SLC24A4 causes hypomineralized amelogenesis imperfecta (AI)"
Medex_00075843-RA	13	Reactome: R-HSA-2408557;Reactome: R-HSA-6791226;Reactome: R-HSA-975956;Reactome: R-HSA-72706;Reactome: R-HSA-72689;Reactome: R-HSA-72764;Reactome: R-HSA-1799339;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-156902;Reactome: R-HSA-9633012;Reactome: R-HSA-975957;Reactome: R-HSA-192823	"Selenocysteine synthesis";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Formation of a pool of free 40S subunits";"Eukaryotic Translation Termination";"SRP-dependent cotranslational protein targeting to membrane";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Peptide chain elongation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Viral mRNA Translation"
Medex_00000081-RA	1	KEGG: 00480+3.4.11.2	"Glutathione metabolism"
Medex_00031254-RA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
Medex_00033569-RA	4	Reactome: R-HSA-2468052;Reactome: R-HSA-2500257;Reactome: R-HSA-2467813;Reactome: R-HSA-2470946	"Establishment of Sister Chromatid Cohesion";"Resolution of Sister Chromatid Cohesion";"Separation of Sister Chromatids";"Cohesin Loading onto Chromatin"
Medex_00023589-RA	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
Medex_00056029-RA	1	Reactome: R-HSA-1632852	"Macroautophagy"
Medex_00083559-RA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
Medex_00062930-RA	3	Reactome: R-HSA-6798695;Reactome: R-HSA-8853383;KEGG: 00511+3.2.1.25	"Neutrophil degranulation";"Lysosomal oligosaccharide catabolism";"Other glycan degradation"
Medex_00053558-RA	2	Reactome: R-HSA-6804115;Reactome: R-HSA-429947	"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Deadenylation of mRNA"
Medex_00041527-RA	3	Reactome: R-HSA-5423646;MetaCyc: PWY-7533;Reactome: R-HSA-2142691	"Aflatoxin activation and detoxification";"Gliotoxin biosynthesis";"Synthesis of Leukotrienes (LT) and Eoxins (EX)"
Medex_00012348-RA	4	Reactome: R-HSA-6781823;Reactome: R-HSA-8856825;Reactome: R-HSA-5696394;Reactome: R-HSA-8951664	"Formation of TC-NER Pre-Incision Complex";"Cargo recognition for clathrin-mediated endocytosis";"DNA Damage Recognition in GG-NER";"Neddylation"
Medex_00079580-RA	1	Reactome: R-HSA-427359	"SIRT1 negatively regulates rRNA expression"
Medex_00043614-RA	1	MetaCyc: PWY-7942	"5-oxo-L-proline metabolism"
Medex_00058226-RA	3	KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16	"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation"
Medex_00004851-RA	2	Reactome: R-HSA-1483191;Reactome: R-HSA-425366	"Synthesis of PC";"Transport of bile salts and organic acids, metal ions and amine compounds"
Medex_00002301-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Medex_00068431-RA	22	MetaCyc: PWY-7053;MetaCyc: PWY-7727;MetaCyc: PWY-5080;MetaCyc: PWY-8041;MetaCyc: PWY-7606;MetaCyc: PWY-6598;MetaCyc: PWY-7602;MetaCyc: PWY-7036;MetaCyc: PWY-6433;MetaCyc: PWY-5353;Reactome: R-HSA-75876;MetaCyc: PWY-6958;MetaCyc: PWY-7601;MetaCyc: PWY-7724;MetaCyc: PWY-7728;MetaCyc: PWY-7592;KEGG: 00062+4.2.1.134;MetaCyc: PWY-7725;MetaCyc: PWY-7619;MetaCyc: PWY-7726;MetaCyc: PWY-7049;MetaCyc: PWY-7035	"Docosahexaenoate biosynthesis I (lower eukaryotes)";"Docosahexaenoate biosynthesis IV (4-desaturase, mammals)";"Very long chain fatty acid biosynthesis I";"Ultra-long-chain fatty acid biosynthesis";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Sciadonate biosynthesis";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis II";"Hydroxylated fatty acid biosynthesis (plants)";"Arachidonate biosynthesis I (6-desaturase, lower eukaryotes)";"Synthesis of very long-chain fatty acyl-CoAs";"Icosapentaenoate biosynthesis I (lower eukaryotes)";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)";"Arachidonate biosynthesis III (6-desaturase, mammals)";"Fatty acid elongation";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Juniperonate biosynthesis";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"Icosapentaenoate biosynthesis II (6-desaturase, mammals)";"(9Z)-tricosene biosynthesis"
Medex_00057224-RA	2	Reactome: R-HSA-390471;Reactome: R-HSA-1660662	"Association of TriC/CCT with target proteins during biosynthesis";"Glycosphingolipid metabolism"
Medex_00059267-RA	3	KEGG: 00790+3.1.3.1;MetaCyc: PWY-5491;KEGG: 00730+3.1.3.1	"Folate biosynthesis";"Diethylphosphate degradation";"Thiamine metabolism"
Medex_00059739-RA	34	Reactome: R-HSA-167160;Reactome: R-HSA-167246;Reactome: R-HSA-167200;Reactome: R-HSA-6782135;Reactome: R-HSA-75955;Reactome: R-HSA-69202;Reactome: R-HSA-167172;Reactome: R-HSA-6781823;Reactome: R-HSA-73779;Reactome: R-HSA-112382;Reactome: R-HSA-6807505;Reactome: R-HSA-113418;Reactome: R-HSA-69231;Reactome: R-HSA-167161;Reactome: R-HSA-75953;Reactome: R-HSA-69273;Reactome: R-HSA-76042;Reactome: R-HSA-167162;Reactome: R-HSA-69656;Reactome: R-HSA-8939236;Reactome: R-HSA-73776;Reactome: R-HSA-674695;Reactome: R-HSA-167152;Reactome: R-HSA-73863;Reactome: R-HSA-73772;Reactome: R-HSA-6782210;Reactome: R-HSA-77075;Reactome: R-HSA-427413;Reactome: R-HSA-6796648;Reactome: R-HSA-72086;Reactome: R-HSA-73762;Reactome: R-HSA-167158;Reactome: R-HSA-5696395;Reactome: R-HSA-6781827	"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Tat-mediated elongation of the HIV-1 transcript";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Dual incision in TC-NER";"RNA Polymerase II Transcription Elongation";"Cyclin E associated events during G1/S transition";"Transcription of the HIV genome";"Formation of TC-NER Pre-Incision Complex";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Formation of RNA Pol II elongation complex";"RNA polymerase II transcribes snRNA genes";"Formation of the Early Elongation Complex";"Cyclin D associated events in G1";"HIV Transcription Initiation";"RNA Polymerase II Transcription Initiation";"Cyclin A/B1/B2 associated events during G2/M transition";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II HIV Promoter Escape";"Cyclin A:Cdk2-associated events at S phase entry";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Pre-transcription Events";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Polymerase I Transcription Termination";"RNA Polymerase I Promoter Escape";"Gap-filling DNA repair synthesis and ligation in TC-NER";"RNA Pol II CTD phosphorylation and interaction with CE";"NoRC negatively regulates rRNA expression";"TP53 Regulates Transcription of DNA Repair Genes";"mRNA Capping";"RNA Polymerase I Transcription Initiation";"Formation of the HIV-1 Early Elongation Complex";"Formation of Incision Complex in GG-NER";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)"
Medex_00003337-RA	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
Medex_00051458-RA	10	Reactome: R-HSA-674695;Reactome: R-HSA-73776;Reactome: R-HSA-167161;Reactome: R-HSA-75953;Reactome: R-HSA-167172;Reactome: R-HSA-3214847;Reactome: R-HSA-6804756;Reactome: R-HSA-73779;Reactome: R-HSA-167162;Reactome: R-HSA-76042	"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Promoter Escape";"HIV Transcription Initiation";"RNA Polymerase II Transcription Initiation";"Transcription of the HIV genome";"HATs acetylate histones";"Regulation of TP53 Activity through Phosphorylation";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Initiation And Promoter Clearance"
Medex_00032820-RA	3	Reactome: R-HSA-5620916;Reactome: R-HSA-264876;Reactome: R-HSA-1445148	"VxPx cargo-targeting to cilium";"Insulin processing";"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
Medex_00042164-RA	1	Reactome: R-HSA-5578775	"Ion homeostasis"
Medex_00021399-RA	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
Medex_00005637-RA	2	Reactome: R-HSA-5655302;Reactome: R-HSA-1839117	"Signaling by FGFR1 in disease";"Signaling by cytosolic FGFR1 fusion mutants"
Medex_00048387-RA	14	MetaCyc: PWY-7601;MetaCyc: PWY-7724;MetaCyc: PWY-8041;MetaCyc: PWY-5080;MetaCyc: PWY-7725;MetaCyc: PWY-6598;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7602;MetaCyc: PWY-7619;MetaCyc: PWY-7036;MetaCyc: PWY-6433;MetaCyc: PWY-7035;Reactome: R-HSA-75876;MetaCyc: PWY-5972	"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Ultra-long-chain fatty acid biosynthesis";"Very long chain fatty acid biosynthesis I";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Sciadonate biosynthesis";"Fatty acid elongation";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Juniperonate biosynthesis";"Very long chain fatty acid biosynthesis II";"Hydroxylated fatty acid biosynthesis (plants)";"(9Z)-tricosene biosynthesis";"Synthesis of very long-chain fatty acyl-CoAs";"Stearate biosynthesis I (animals)"
Medex_00040921-RA	1	Reactome: R-HSA-426117	"Cation-coupled Chloride cotransporters"
Medex_00079172-RA	2	Reactome: R-HSA-71403;Reactome: R-HSA-611105	"Citric acid cycle (TCA cycle)";"Respiratory electron transport"
Medex_00034248-RA	1	Reactome: R-HSA-70221	"Glycogen breakdown (glycogenolysis)"
Medex_00059904-RA	4	MetaCyc: PWY-6129;Reactome: R-HSA-446199;Reactome: R-HSA-4755583;KEGG: 00510+2.7.1.108	"Dolichol and dolichyl phosphate biosynthesis";"Synthesis of Dolichyl-phosphate";"Defective DOLK causes DOLK-CDG (CDG-1m)";"N-Glycan biosynthesis"
Medex_00006346-RA	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5419276;Reactome: R-HSA-5368286	"Mitochondrial translation elongation";"Mitochondrial translation termination";"Mitochondrial translation initiation"
Medex_00016065-RA	3	Reactome: R-HSA-5655862;Reactome: R-HSA-5656121;Reactome: R-HSA-110312	"Translesion synthesis by POLK";"Translesion synthesis by POLI";"Translesion synthesis by REV1"
Medex_00092862-RA	2	Reactome: R-HSA-611105;Reactome: R-HSA-5628897	"Respiratory electron transport";"TP53 Regulates Metabolic Genes"
Medex_00032298-RA	5	Reactome: R-HSA-917977;Reactome: R-HSA-1222556;Reactome: R-HSA-9639288;Reactome: R-HSA-77387;Reactome: R-HSA-983712	"Transferrin endocytosis and recycling";"ROS and RNS production in phagocytes";"Amino acids regulate mTORC1";"Insulin receptor recycling";"Ion channel transport"
Medex_00039164-RA	1	Reactome: R-HSA-5658442	"Regulation of RAS by GAPs"
Medex_00092826-RA	1	Reactome: R-HSA-6803157	"Antimicrobial peptides"
Medex_00036571-RA	2	Reactome: R-HSA-4086398;Reactome: R-HSA-418457	"Ca2+ pathway";"cGMP effects"
Medex_00062631-RA	2	Reactome: R-HSA-2022854;Reactome: R-HSA-975577	"Keratan sulfate biosynthesis";"N-Glycan antennae elongation"
Medex_00074922-RA	2	KEGG: 00230+2.7.4.8;MetaCyc: PWY-7221	"Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis"
Medex_00055736-RA	7	MetaCyc: PWY-6074;Reactome: R-HSA-191273;MetaCyc: PWY-8026;MetaCyc: PWY-7154;Reactome: R-HSA-9022692;KEGG: 00100+1.3.1.70;MetaCyc: PWY-2541	"Zymosterol biosynthesis";"Cholesterol biosynthesis";"Sterol biosynthesis (methylotrophs)";"Ergosterol biosynthesis II";"Regulation of MECP2 expression and activity";"Steroid biosynthesis";"Phytosterol biosynthesis (plants)"
Medex_00018159-RA	9	Reactome: R-HSA-76042;Reactome: R-HSA-167162;Reactome: R-HSA-73779;Reactome: R-HSA-6804756;Reactome: R-HSA-167172;Reactome: R-HSA-75953;Reactome: R-HSA-167161;Reactome: R-HSA-73776;Reactome: R-HSA-674695	"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Regulation of TP53 Activity through Phosphorylation";"Transcription of the HIV genome";"RNA Polymerase II Transcription Initiation";"HIV Transcription Initiation";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Pre-transcription Events"
Medex_00022302-RA	6	MetaCyc: PWY-622;Reactome: R-HSA-3878781;Reactome: R-HSA-3322077;MetaCyc: PWY-7900;MetaCyc: PWY-5067;KEGG: 00500+2.4.1.18	"Starch biosynthesis";"Glycogen storage disease type IV (GBE1)";"Glycogen synthesis";"Glycogen biosynthesis III (from alpha-maltose 1-phosphate)";"Glycogen biosynthesis II (from UDP-D-Glucose)";"Starch and sucrose metabolism"
Medex_00075401-RA	5	Reactome: R-HSA-390471;Reactome: R-HSA-389960;Reactome: R-HSA-390450;Reactome: R-HSA-389957;Reactome: R-HSA-6814122	"Association of TriC/CCT with target proteins during biosynthesis";"Formation of tubulin folding intermediates by CCT/TriC";"Folding of actin by CCT/TriC";"Prefoldin mediated transfer of substrate to CCT/TriC";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"
Medex_00089029-RA	3	KEGG: 00730+3.1.3.1;KEGG: 00790+3.1.3.1;MetaCyc: PWY-5491	"Thiamine metabolism";"Folate biosynthesis";"Diethylphosphate degradation"
Medex_00041128-RA	14	MetaCyc: PWY-7036;MetaCyc: PWY-7619;MetaCyc: PWY-7602;MetaCyc: PWY-6433;MetaCyc: PWY-5972;MetaCyc: PWY-7035;Reactome: R-HSA-75876;MetaCyc: PWY-7601;MetaCyc: PWY-7724;MetaCyc: PWY-5080;MetaCyc: PWY-8041;MetaCyc: PWY-6598;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7725	"Very long chain fatty acid biosynthesis II";"Juniperonate biosynthesis";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Hydroxylated fatty acid biosynthesis (plants)";"Stearate biosynthesis I (animals)";"(9Z)-tricosene biosynthesis";"Synthesis of very long-chain fatty acyl-CoAs";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Very long chain fatty acid biosynthesis I";"Ultra-long-chain fatty acid biosynthesis";"Sciadonate biosynthesis";"Fatty acid elongation";"Arachidonate biosynthesis V (8-detaturase, mammals)"
Medex_00080012-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00030900-RA	6	Reactome: R-HSA-6798695;Reactome: R-HSA-9033241;KEGG: 00630+1.11.1.6;KEGG: 00380+1.11.1.6;Reactome: R-HSA-3299685;Reactome: R-HSA-9615017	"Neutrophil degranulation";"Peroxisomal protein import";"Glyoxylate and dicarboxylate metabolism";"Tryptophan metabolism";"Detoxification of Reactive Oxygen Species";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes"
Medex_00098810-RA	15	MetaCyc: PWY-6886;Reactome: R-HSA-70171;KEGG: 00230+2.7.1.40;MetaCyc: PWY-2221;KEGG: 00620+2.7.1.40;MetaCyc: PWY-6901;MetaCyc: PWY-6142;MetaCyc: PWY-7003;MetaCyc: PWY-5723;MetaCyc: PWY-1042;MetaCyc: PWY-8004;MetaCyc: PWY-7383;MetaCyc: PWY-7218;KEGG: 00010+2.7.1.40;MetaCyc: PWY-5484	"1-butanol autotrophic biosynthesis (engineered)";"Glycolysis";"Purine metabolism";"Entner-Doudoroff pathway III (semi-phosphorylative)";"Pyruvate metabolism";"Superpathway of glucose and xylose degradation";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Glycerol degradation to butanol";"Rubisco shunt";"Glycolysis IV (plant cytosol)";"Entner-Doudoroff pathway I";"Anaerobic energy metabolism (invertebrates, cytosol)";"Photosynthetic 3-hydroxybutanoate biosynthesis (engineered)";"Glycolysis / Gluconeogenesis";"Glycolysis II (from fructose 6-phosphate)"
Medex_00029529-RA	3	Reactome: R-HSA-6798695;KEGG: 00511+3.2.1.51;MetaCyc: PWY-6807	"Neutrophil degranulation";"Other glycan degradation";"Xyloglucan degradation II (exoglucanase)"
Medex_00032416-RA	19	KEGG: 00071+1.3.3.6;MetaCyc: PWY-7574;MetaCyc: PWY-7337;MetaCyc: PWY-7288;MetaCyc: PWY-6920;KEGG: 00410+1.3.3.6;MetaCyc: PWY-7726;KEGG: 00592+1.3.3.6;MetaCyc: PWY-7854;MetaCyc: PWY-7007;MetaCyc: PWY-7338;MetaCyc: PWY-5136;MetaCyc: PWY-7291;MetaCyc: PWY-7606;MetaCyc: PWY-735;KEGG: 00640+1.3.3.6;MetaCyc: PWY-7340;MetaCyc: PWY-7858;MetaCyc: PWY-6837	"Fatty acid degradation";"Propanoyl-coa degradation II";"10-cis-heptadecenoyl-CoA degradation (yeast)";"Fatty acid beta-oxidation VII (yeast peroxisome)";"6-gingerol analog biosynthesis (engineered)";"beta-Alanine metabolism";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"alpha-Linolenic acid metabolism";"Crotonyl-coa/ethylmalonyl-coa/hydroxybutyryl-coa cycle (engineered)";"Methyl ketone biosynthesis (engineered)";"10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast)";"Fatty acid beta-oxidation II (plant peroxisome)";"Oleate beta-oxidation (isomerase-dependent, yeast)";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Jasmonic acid biosynthesis";"Propanoate metabolism";"9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast)";"(5Z)-dodecenoate biosynthesis II";"Fatty acid beta-oxidation V (unsaturated, odd number, di-isomerase-dependent)"
Medex_00066639-RA	2	Reactome: R-HSA-1169408;Reactome: R-HSA-168276	"ISG15 antiviral mechanism";"NS1 Mediated Effects on Host Pathways"
Medex_00073771-RA	16	Reactome: R-HSA-2408557;Reactome: R-HSA-72689;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-72695;Reactome: R-HSA-156902;Reactome: R-HSA-72649;Reactome: R-HSA-192823;Reactome: R-HSA-6791226;Reactome: R-HSA-72702;Reactome: R-HSA-72764;Reactome: R-HSA-975956;Reactome: R-HSA-72706;Reactome: R-HSA-9633012;Reactome: R-HSA-1799339;Reactome: R-HSA-975957	"Selenocysteine synthesis";"Formation of a pool of free 40S subunits";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Formation of the ternary complex, and subsequently, the 43S complex";"Peptide chain elongation";"Translation initiation complex formation";"Viral mRNA Translation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Ribosomal scanning and start codon recognition";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
Medex_00069859-RA	2	Reactome: R-HSA-5576893;Reactome: R-HSA-5576892	"Phase 2 - plateau phase";"Phase 0 - rapid depolarisation"
Medex_00077139-RA	56	Reactome: R-HSA-5632684;Reactome: R-HSA-1236978;Reactome: R-HSA-349425;Reactome: R-HSA-180534;Reactome: R-HSA-5607761;Reactome: R-HSA-5610780;Reactome: R-HSA-8852276;Reactome: R-HSA-174178;Reactome: R-HSA-8939902;Reactome: R-HSA-75815;Reactome: R-HSA-195253;Reactome: R-HSA-5610785;Reactome: R-HSA-5689880;Reactome: R-HSA-5687128;Reactome: R-HSA-5668541;Reactome: R-HSA-5689603;Reactome: R-HSA-4608870;Reactome: R-HSA-4641258;Reactome: R-HSA-2467813;Reactome: R-HSA-180585;Reactome: R-HSA-450408;Reactome: R-HSA-9010553;Reactome: R-HSA-8939236;Reactome: R-HSA-211733;Reactome: R-HSA-68949;Reactome: R-HSA-382556;Reactome: R-HSA-5658442;Reactome: R-HSA-5358346;Reactome: R-HSA-8941858;Reactome: R-HSA-983168;Reactome: R-HSA-202424;Reactome: R-HSA-9020702;Reactome: R-HSA-1169091;Reactome: R-HSA-174154;Reactome: R-HSA-5607764;Reactome: R-HSA-174184;Reactome: R-HSA-8951664;Reactome: R-HSA-2871837;Reactome: R-HSA-350562;Reactome: R-HSA-5678895;Reactome: R-HSA-69481;Reactome: R-HSA-174113;Reactome: R-HSA-4641257;Reactome: R-HSA-1234176;Reactome: R-HSA-5362768;Reactome: R-HSA-69017;Reactome: R-HSA-69601;Reactome: R-HSA-5676590;Reactome: R-HSA-8948751;Reactome: R-HSA-68827;Reactome: R-HSA-9604323;Reactome: R-HSA-5610783;Reactome: R-HSA-1236974;Reactome: R-HSA-8854050;Reactome: R-HSA-187577;Reactome: R-HSA-174084	"Hedgehog 'on' state";"Cross-presentation of soluble exogenous antigens (endosomes)";"Autodegradation of the E3 ubiquitin ligase COP1";"Vpu mediated degradation of CD4";"Dectin-1 mediated noncanonical NF-kB signaling";"Degradation of GLI1 by the proteasome";"The role of GTSE1 in G2/M progression after G2 checkpoint";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Regulation of RUNX2 expression and activity";"Ubiquitin-dependent degradation of Cyclin D";"Degradation of beta-catenin by the destruction complex";"GLI3 is processed to GLI3R by the proteasome";"Ub-specific processing proteases";"MAPK6/MAPK4 signaling";"TNFR2 non-canonical NF-kB pathway";"UCH proteinases";"Asymmetric localization of PCP proteins";"Degradation of DVL";"Separation of Sister Chromatids";"Vif-mediated degradation of APOBEC3G";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Regulation of expression of SLITs and ROBOs";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Orc1 removal from chromatin";"ABC-family proteins mediated transport";"Regulation of RAS by GAPs";"Hedgehog ligand biogenesis";"Regulation of RUNX3 expression and activity";"Antigen processing: Ubiquitination & Proteasome degradation";"Downstream TCR signaling";"Interleukin-1 signaling";"Activation of NF-kappaB in B cells";"APC/C:Cdc20 mediated degradation of Securin";"CLEC7A (Dectin-1) signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Neddylation";"FCERI mediated NF-kB activation";"Regulation of ornithine decarboxylase (ODC)";"Defective CFTR causes cystic fibrosis";"G2/M Checkpoints";"SCF-beta-TrCP mediated degradation of Emi1";"Degradation of AXIN";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"CDK-mediated phosphorylation and removal of Cdc6";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"NIK-->noncanonical NF-kB signaling";"Regulation of PTEN stability and activity";"CDT1 association with the CDC6:ORC:origin complex";"Negative regulation of NOTCH4 signaling";"Degradation of GLI2 by the proteasome";"ER-Phagosome pathway";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"SCF(Skp2)-mediated degradation of p27/p21";"Autodegradation of Cdh1 by Cdh1:APC/C"
Medex_00057578-RA	1	Reactome: R-HSA-5676934	"Protein repair"
Medex_00073577-RA	2	Reactome: R-HSA-2206307;Reactome: R-HSA-2024096	"MPS IIIA - Sanfilippo syndrome A";"HS-GAG degradation"
Medex_00003832-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00082830-RA	26	Reactome: R-HSA-68877;Reactome: R-HSA-6811434;Reactome: R-HSA-9648025;Reactome: R-HSA-389977;Reactome: R-HSA-2467813;Reactome: R-HSA-9646399;Reactome: R-HSA-5617833;Reactome: R-HSA-2500257;Reactome: R-HSA-380320;Reactome: R-HSA-3371497;Reactome: R-HSA-5663220;Reactome: R-HSA-1445148;Reactome: R-HSA-389960;Reactome: R-HSA-8852276;Reactome: R-HSA-983189;Reactome: R-HSA-9609736;Reactome: R-HSA-5626467;Reactome: R-HSA-2132295;Reactome: R-HSA-190861;Reactome: R-HSA-190840;Reactome: R-HSA-6807878;Reactome: R-HSA-437239;Reactome: R-HSA-9619483;Reactome: R-HSA-6811436;Reactome: R-HSA-9609690;Reactome: R-HSA-8955332	"Mitotic Prometaphase";"COPI-dependent Golgi-to-ER retrograde traffic";"EML4 and NUDC in mitotic spindle formation";"Post-chaperonin tubulin folding pathway";"Separation of Sister Chromatids";"Aggrephagy";"Cilium Assembly";"Resolution of Sister Chromatid Cohesion";"Recruitment of NuMA to mitotic centrosomes";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"RHO GTPases Activate Formins";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Formation of tubulin folding intermediates by CCT/TriC";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Kinesins";"Assembly and cell surface presentation of NMDA receptors";"RHO GTPases activate IQGAPs";"MHC class II antigen presentation";"Gap junction assembly";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"COPI-mediated anterograde transport";"Recycling pathway of L1";"Activation of AMPK downstream of NMDARs";"COPI-independent Golgi-to-ER retrograde traffic";"HCMV Early Events";"Carboxyterminal post-translational modifications of tubulin"
Medex_00032690-RA	4	MetaCyc: PWY-6987;Reactome: R-HSA-389661;MetaCyc: PWY-7382;KEGG: 00785+2.3.1.181	"Lipoate biosynthesis and incorporation III (Bacillus)";"Glyoxylate metabolism and glycine degradation";"Lipoate biosynthesis and incorporation IV (yeast)";"Lipoic acid metabolism"
Medex_00082022-RA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00009623-RA	1	Reactome: R-HSA-6811436	"COPI-independent Golgi-to-ER retrograde traffic"
Medex_00024512-RA	2	MetaCyc: PWY-5697;KEGG: 00230+3.5.3.4	"Allantoin degradation to ureidoglycolate I (urea producing)";"Purine metabolism"
Medex_00053784-RA	4	MetaCyc: PWY-7807;MetaCyc: PWY-7805;Reactome: R-HSA-71737;KEGG: 00190+3.6.1.1	"Glyphosate degradation III";"(aminomethyl)phosphonate degradation";"Pyrophosphate hydrolysis";"Oxidative phosphorylation"
Medex_00075580-RA	29	Reactome: R-HSA-73863;Reactome: R-HSA-73776;Reactome: R-HSA-674695;Reactome: R-HSA-167152;Reactome: R-HSA-6782210;Reactome: R-HSA-167172;Reactome: R-HSA-6781823;Reactome: R-HSA-73772;Reactome: R-HSA-167200;Reactome: R-HSA-167246;Reactome: R-HSA-167160;Reactome: R-HSA-76042;Reactome: R-HSA-6782135;Reactome: R-HSA-167162;Reactome: R-HSA-75955;Reactome: R-HSA-113418;Reactome: R-HSA-73762;Reactome: R-HSA-167158;Reactome: R-HSA-5696395;Reactome: R-HSA-75953;Reactome: R-HSA-6781827;Reactome: R-HSA-167161;Reactome: R-HSA-77075;Reactome: R-HSA-427413;Reactome: R-HSA-5696400;Reactome: R-HSA-72086;Reactome: R-HSA-73779;Reactome: R-HSA-112382;Reactome: R-HSA-6796648	"RNA Polymerase I Transcription Termination";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Pre-transcription Events";"Formation of HIV elongation complex in the absence of HIV Tat";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Transcription of the HIV genome";"Formation of TC-NER Pre-Incision Complex";"RNA Polymerase I Promoter Escape";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Tat-mediated elongation of the HIV-1 transcript";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Dual incision in TC-NER";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Elongation";"Formation of the Early Elongation Complex";"RNA Polymerase I Transcription Initiation";"Formation of the HIV-1 Early Elongation Complex";"Formation of Incision Complex in GG-NER";"RNA Polymerase II Transcription Initiation";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"HIV Transcription Initiation";"RNA Pol II CTD phosphorylation and interaction with CE";"NoRC negatively regulates rRNA expression";"Dual Incision in GG-NER";"mRNA Capping";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Formation of RNA Pol II elongation complex";"TP53 Regulates Transcription of DNA Repair Genes"
Medex_00042441-RA	1	KEGG: 00970+6.1.1.19	"Aminoacyl-tRNA biosynthesis"
Medex_00033385-RA	1	Reactome: R-HSA-8951664	"Neddylation"
Medex_00039742-RA	2	Reactome: R-HSA-8950505;Reactome: R-HSA-1237112	"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation";"Methionine salvage pathway"
Medex_00022442-RA	2	Reactome: R-HSA-2151201;Reactome: R-HSA-1989781	"Transcriptional activation of mitochondrial biogenesis";"PPARA activates gene expression"
Medex_00041669-RA	2	Reactome: R-HSA-1660662;Reactome: R-HSA-390471	"Glycosphingolipid metabolism";"Association of TriC/CCT with target proteins during biosynthesis"
Medex_00080331-RA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
Medex_00044038-RA	4	Reactome: R-HSA-1268020;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276	"Mitochondrial protein import";"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination"
Medex_00093941-RA	13	Reactome: R-HSA-2408557;Reactome: R-HSA-6791226;Reactome: R-HSA-72706;Reactome: R-HSA-975956;Reactome: R-HSA-72764;Reactome: R-HSA-72689;Reactome: R-HSA-1799339;Reactome: R-HSA-156902;Reactome: R-HSA-9633012;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-975957;Reactome: R-HSA-192823	"Selenocysteine synthesis";"Major pathway of rRNA processing in the nucleolus and cytosol";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Formation of a pool of free 40S subunits";"SRP-dependent cotranslational protein targeting to membrane";"Peptide chain elongation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Viral mRNA Translation"
Medex_00048883-RA	4	Reactome: R-HSA-418359;Reactome: R-HSA-1912420;Reactome: R-HSA-5578775;Reactome: R-HSA-936837	"Reduction of cytosolic Ca++ levels";"Pre-NOTCH Processing in Golgi";"Ion homeostasis";"Ion transport by P-type ATPases"
Medex_00090184-RA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00072472-RA	2	Reactome: R-HSA-380320;Reactome: R-HSA-380270	"Recruitment of NuMA to mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes"
Medex_00038033-RA	18	KEGG: 00250+2.6.1.1;MetaCyc: PWY-7117;KEGG: 00710+2.6.1.1;KEGG: 00330+2.6.1.1;KEGG: 00960+2.6.1.1;KEGG: 00401+2.6.1.1;KEGG: 00400+2.6.1.1;KEGG: 00950+2.6.1.1;KEGG: 00220+2.6.1.1;KEGG: 00350+2.6.1.1;KEGG: 00360+2.6.1.1;KEGG: 00270+2.6.1.1;MetaCyc: PWY-6643;MetaCyc: PWY-5913;MetaCyc: PWY-7115;MetaCyc: PWY-7383;MetaCyc: PWY-6638;MetaCyc: PWY-6642	"Alanine, aspartate and glutamate metabolism";"C4 photosynthetic carbon assimilation cycle, PEPCK type";"Carbon fixation in photosynthetic organisms";"Arginine and proline metabolism";"Tropane, piperidine and pyridine alkaloid biosynthesis";"Novobiocin biosynthesis";"Phenylalanine, tyrosine and tryptophan biosynthesis";"Isoquinoline alkaloid biosynthesis";"Arginine biosynthesis";"Tyrosine metabolism";"Phenylalanine metabolism";"Cysteine and methionine metabolism";"Coenzyme M biosynthesis II";"Partial TCA cycle (obligate autotrophs)";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"Anaerobic energy metabolism (invertebrates, cytosol)";"Sulfolactate degradation III";"(R)-cysteate degradation"
Medex_00070142-RA	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
Medex_00006153-RA	8	Reactome: R-HSA-191273;KEGG: 00900+1.1.1.34;MetaCyc: PWY-922;MetaCyc: PWY-7391;MetaCyc: PWY-6174;Reactome: R-HSA-1989781;MetaCyc: PWY-7524;Reactome: R-HSA-2426168	"Cholesterol biosynthesis";"Terpenoid backbone biosynthesis";"Mevalonate pathway I";"Isoprene biosynthesis II (engineered)";"Mevalonate pathway II (archaea)";"PPARA activates gene expression";"Mevalonate pathway III (archaea)";"Activation of gene expression by SREBF (SREBP)"
Medex_00051534-RA	1	Reactome: R-HSA-5368286	"Mitochondrial translation initiation"
Medex_00005309-RA	1	Reactome: R-HSA-8951664	"Neddylation"
Medex_00056681-RA	3	Reactome: R-HSA-8876725;Reactome: R-HSA-2514859;KEGG: 00310+2.1.1.60	"Protein methylation";"Inactivation, recovery and regulation of the phototransduction cascade";"Lysine degradation"
Medex_00037603-RA	1	Reactome: R-HSA-5620912	"Anchoring of the basal body to the plasma membrane"
Medex_00067482-RA	2	Reactome: R-HSA-191859;Reactome: R-HSA-6807505	"snRNP Assembly";"RNA polymerase II transcribes snRNA genes"
Medex_00059841-RA	1	Reactome: R-HSA-2151201	"Transcriptional activation of mitochondrial biogenesis"
Medex_00000407-RA	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
Medex_00065881-RA	5	Reactome: R-HSA-2644606;Reactome: R-HSA-2122947;Reactome: R-HSA-3214815;Reactome: R-HSA-2894862;Reactome: R-HSA-350054	"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH1 Intracellular Domain Regulates Transcription";"HDACs deacetylate histones";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Notch-HLH transcription pathway"
Medex_00042436-RA	8	Reactome: R-HSA-9636467;Reactome: R-HSA-1222556;Reactome: R-HSA-9639288;Reactome: R-HSA-77387;Reactome: R-HSA-983712;Reactome: R-HSA-917977;Reactome: R-HSA-167590;Reactome: R-HSA-182218	"Blockage of phagosome acidification";"ROS and RNS production in phagocytes";"Amino acids regulate mTORC1";"Insulin receptor recycling";"Ion channel transport";"Transferrin endocytosis and recycling";"Nef Mediated CD4 Down-regulation";"Nef Mediated CD8 Down-regulation"
Medex_00085027-RA	5	Reactome: R-HSA-5578775;Reactome: R-HSA-2500257;Reactome: R-HSA-2468052;Reactome: R-HSA-2470946;Reactome: R-HSA-2467813	"Ion homeostasis";"Resolution of Sister Chromatid Cohesion";"Establishment of Sister Chromatid Cohesion";"Cohesin Loading onto Chromatin";"Separation of Sister Chromatids"
Medex_00051598-RA	2	Reactome: R-HSA-382556;Reactome: R-HSA-5678895	"ABC-family proteins mediated transport";"Defective CFTR causes cystic fibrosis"
Medex_00034317-RA	5	MetaCyc: PWY-5981;MetaCyc: PWY-7902;KEGG: 00564+1.1.1.94;MetaCyc: PWY-5667;Reactome: R-HSA-1483166	"CDP-diacylglycerol biosynthesis III";"Glucosylglycerol biosynthesis";"Glycerophospholipid metabolism";"CDP-diacylglycerol biosynthesis I";"Synthesis of PA"
Medex_00006973-RA	2	Reactome: R-HSA-8949664;Reactome: R-HSA-8949215	"Processing of SMDT1";"Mitochondrial calcium ion transport"
Medex_00058951-RA	1	Reactome: R-HSA-6807878	"COPI-mediated anterograde transport"
Medex_00001463-RA	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840	"Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation"
Medex_00058397-RA	9	KEGG: 00511+3.2.1.52;MetaCyc: PWY-7822;KEGG: 00513+3.2.1.52;KEGG: 00604+3.2.1.52;MetaCyc: PWY-6902;MetaCyc: PWY-7883;KEGG: 00603+3.2.1.52;KEGG: 00520+3.2.1.52;KEGG: 00531+3.2.1.52	"Other glycan degradation";"Chitin degradation III (Serratia)";"Various types of N-glycan biosynthesis";"Glycosphingolipid biosynthesis - ganglio series";"Chitin degradation II (Vibrio)";"Anhydromuropeptides recycling II";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Amino sugar and nucleotide sugar metabolism";"Glycosaminoglycan degradation"
Medex_00006504-RA	13	Reactome: R-HSA-156902;Reactome: R-HSA-9633012;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-1799339;Reactome: R-HSA-192823;Reactome: R-HSA-975957;Reactome: R-HSA-6791226;Reactome: R-HSA-2408557;Reactome: R-HSA-72764;Reactome: R-HSA-72689;Reactome: R-HSA-72706;Reactome: R-HSA-975956	"Peptide chain elongation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"SRP-dependent cotranslational protein targeting to membrane";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"Selenocysteine synthesis";"Eukaryotic Translation Termination";"Formation of a pool of free 40S subunits";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"
Medex_00022590-RA	13	Reactome: R-HSA-2029485;Reactome: R-HSA-112043;Reactome: R-HSA-422356;Reactome: R-HSA-1489509;Reactome: R-HSA-139853;Reactome: R-HSA-983695;Reactome: R-HSA-5218921;Reactome: R-HSA-381676;Reactome: R-HSA-2871809;Reactome: R-HSA-4086398;Reactome: R-HSA-114508;Reactome: R-HSA-5578775;Reactome: R-HSA-5607763	"Role of phospholipids in phagocytosis";"PLC beta mediated events";"Regulation of insulin secretion";"DAG and IP3 signaling";"Elevation of cytosolic Ca2+ levels";"Antigen activates B Cell Receptor (BCR) leading to generation of second messengers";"VEGFR2 mediated cell proliferation";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"FCERI mediated Ca+2 mobilization";"Ca2+ pathway";"Effects of PIP2 hydrolysis";"Ion homeostasis";"CLEC7A (Dectin-1) induces NFAT activation"
Medex_00079947-RA	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
Medex_00027921-RA	8	MetaCyc: PWY-7980;KEGG: 00190+7.1.2.2;KEGG: 00195+7.1.2.2;Reactome: R-HSA-917977;Reactome: R-HSA-9639288;Reactome: R-HSA-1222556;Reactome: R-HSA-983712;Reactome: R-HSA-77387	"ATP biosynthesis";"Oxidative phosphorylation";"Photosynthesis";"Transferrin endocytosis and recycling";"Amino acids regulate mTORC1";"ROS and RNS production in phagocytes";"Ion channel transport";"Insulin receptor recycling"
Medex_00095368-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00011620-RA	8	KEGG: 04714+2.7.11.1;KEGG: 04660+2.7.10.2;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04151+2.7.11.1	"Thermogenesis";"T cell receptor signaling pathway";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"Human papillomavirus infection";"Relaxin signaling pathway";"Human cytomegalovirus infection";"PI3K-Akt signaling pathway"
Medex_00023397-RA	5	MetaCyc: PWY-7766;KEGG: 00860+4.1.1.37;MetaCyc: PWY-7159;Reactome: R-HSA-189451;MetaCyc: PWY-5531	"Heme b biosynthesis IV (Gram-positive bacteria)";"Porphyrin and chlorophyll metabolism";"3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent)";"Heme biosynthesis";"3,8-divinyl-chlorophyllide a biosynthesis II (anaerobic)"
Medex_00047094-RA	4	Reactome: R-HSA-5663213;Reactome: R-HSA-3928662;Reactome: R-HSA-8856828;Reactome: R-HSA-2029482	"RHO GTPases Activate WASPs and WAVEs";"EPHB-mediated forward signaling";"Clathrin-mediated endocytosis";"Regulation of actin dynamics for phagocytic cup formation"
Medex_00019507-RA	11	MetaCyc: PWY-6728;MetaCyc: PWY-5913;MetaCyc: PWY-6969;MetaCyc: PWY-7254;KEGG: 00480+1.1.1.42;MetaCyc: PWY-7124;MetaCyc: PWY-6549;KEGG: 00720+1.1.1.42;KEGG: 00020+1.1.1.42;MetaCyc: PWY-7268;Reactome: R-HSA-71403	"Methylaspartate cycle";"Partial TCA cycle (obligate autotrophs)";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"TCA cycle VII (acetate-producers)";"Glutathione metabolism";"Ethylene biosynthesis V (engineered)";"L-glutamine biosynthesis III";"Carbon fixation pathways in prokaryotes";"Citrate cycle (TCA cycle)";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"Citric acid cycle (TCA cycle)"
Medex_00068811-RA	2	Reactome: R-HSA-5610787;Reactome: R-HSA-5620924	"Hedgehog 'off' state";"Intraflagellar transport"
Medex_00007181-RA	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
Medex_00089273-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Medex_00012931-RA	3	Reactome: R-HSA-159236;Reactome: R-HSA-73856;Reactome: R-HSA-72187	"Transport of Mature mRNA derived from an Intron-Containing Transcript";"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing"
Medex_00030232-RA	3	Reactome: R-HSA-6798695;Reactome: R-HSA-6794361;Reactome: R-HSA-264870	"Neutrophil degranulation";"Neurexins and neuroligins";"Caspase-mediated cleavage of cytoskeletal proteins"
Medex_00029224-RA	1	KEGG: 00290+4.2.1.33	"Valine, leucine and isoleucine biosynthesis"
Medex_00050858-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Medex_00079490-RA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Medex_00082929-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Medex_00026272-RA	1	Reactome: R-HSA-1362409	"Mitochondrial iron-sulfur cluster biogenesis"
Medex_00079359-RA	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
Medex_00083590-RA	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
Medex_00053012-RA	2	Reactome: R-HSA-5693571;Reactome: R-HSA-164843	"Nonhomologous End-Joining (NHEJ)";"2-LTR circle formation"
Medex_00072603-RA	2	Reactome: R-HSA-3214847;Reactome: R-HSA-427413	"HATs acetylate histones";"NoRC negatively regulates rRNA expression"
Medex_00008742-RA	3	Reactome: R-HSA-2142691;Reactome: R-HSA-5423646;MetaCyc: PWY-7533	"Synthesis of Leukotrienes (LT) and Eoxins (EX)";"Aflatoxin activation and detoxification";"Gliotoxin biosynthesis"
Medex_00084501-RA	8	Reactome: R-HSA-3371571;Reactome: R-HSA-380972;Reactome: R-HSA-166208;Reactome: R-HSA-1632852;Reactome: R-HSA-9639288;Reactome: R-HSA-165159;Reactome: R-HSA-5628897;Reactome: R-HSA-8943724	"HSF1-dependent transactivation";"Energy dependent regulation of mTOR by LKB1-AMPK";"mTORC1-mediated signalling";"Macroautophagy";"Amino acids regulate mTORC1";"mTOR signalling";"TP53 Regulates Metabolic Genes";"Regulation of PTEN gene transcription"
Medex_00079109-RA	20	Reactome: R-HSA-9639288;KEGG: 04150+2.7.11.1;Reactome: R-HSA-1257604;KEGG: 04714+2.7.11.1;Reactome: R-HSA-3371571;KEGG: 04151+2.7.11.1;Reactome: R-HSA-5628897;Reactome: R-HSA-389357;Reactome: R-HSA-5674400;Reactome: R-HSA-5218920;KEGG: 05163+2.7.11.1;Reactome: R-HSA-166208;KEGG: 05170+2.7.11.1;Reactome: R-HSA-165159;Reactome: R-HSA-1632852;KEGG: 05165+2.7.11.1;Reactome: R-HSA-380972;Reactome: R-HSA-8943724;KEGG: 04926+2.7.11.1;Reactome: R-HSA-6804757	"Amino acids regulate mTORC1";"mTOR signaling pathway";"PIP3 activates AKT signaling";"Thermogenesis";"HSF1-dependent transactivation";"PI3K-Akt signaling pathway";"TP53 Regulates Metabolic Genes";"CD28 dependent PI3K/Akt signaling";"Constitutive Signaling by AKT1 E17K in Cancer";"VEGFR2 mediated vascular permeability";"Human cytomegalovirus infection";"mTORC1-mediated signalling";"Human immunodeficiency virus 1 infection";"mTOR signalling";"Macroautophagy";"Human papillomavirus infection";"Energy dependent regulation of mTOR by LKB1-AMPK";"Regulation of PTEN gene transcription";"Relaxin signaling pathway";"Regulation of TP53 Degradation"
Medex_00093531-RA	1	Reactome: R-HSA-211945	"Phase I - Functionalization of compounds"
Medex_00076456-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Medex_00006440-RA	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
Medex_00012707-RA	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
Medex_00000524-RA	1	Reactome: R-HSA-211981	"Xenobiotics"
Medex_00080954-RA	2	Reactome: R-HSA-2470946;Reactome: R-HSA-1799339	"Cohesin Loading onto Chromatin";"SRP-dependent cotranslational protein targeting to membrane"
Medex_00097551-RA	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5419276;Reactome: R-HSA-5368286	"Mitochondrial translation elongation";"Mitochondrial translation termination";"Mitochondrial translation initiation"
Medex_00023993-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Medex_00022758-RA	1	Reactome: R-HSA-5610787	"Hedgehog 'off' state"
Medex_00036173-RA	1	KEGG: 00290+4.2.1.33	"Valine, leucine and isoleucine biosynthesis"
Medex_00056868-RA	16	Reactome: R-HSA-6802955;Reactome: R-HSA-6802952;Reactome: R-HSA-216083;Reactome: R-HSA-372708;Reactome: R-HSA-977225;Reactome: R-HSA-140875;Reactome: R-HSA-5686938;Reactome: R-HSA-114608;Reactome: R-HSA-6802948;Reactome: R-HSA-354194;Reactome: R-HSA-5674135;Reactome: R-HSA-354192;Reactome: R-HSA-6802946;Reactome: R-HSA-9649948;Reactome: R-HSA-8957275;Reactome: R-HSA-381426	"Paradoxical activation of RAF signaling by kinase inactive BRAF";"Signaling by BRAF and RAF fusions";"Integrin cell surface interactions";"p130Cas linkage to MAPK signaling for integrins";"Amyloid fiber formation";"Common Pathway of Fibrin Clot Formation";"Regulation of TLR by endogenous ligand";"Platelet degranulation";"Signaling by high-kinase activity BRAF mutants";"GRB2:SOS provides linkage to MAPK signaling for Integrins";"MAP2K and MAPK activation";"Integrin signaling";"Signaling by moderate kinase activity BRAF mutants";"Signaling downstream of RAS mutants";"Post-translational protein phosphorylation";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"
Medex_00088431-RA	1	Reactome: R-HSA-1632852	"Macroautophagy"
Medex_00005826-RA	19	Reactome: R-HSA-3371571;Reactome: R-HSA-5673001;Reactome: R-HSA-111932;Reactome: R-HSA-6802946;Reactome: R-HSA-9649948;Reactome: R-HSA-9022692;Reactome: R-HSA-9620244;Reactome: R-HSA-936837;Reactome: R-HSA-9609736;Reactome: R-HSA-5673000;Reactome: R-HSA-442982;Reactome: R-HSA-9617324;Reactome: R-HSA-5578775;Reactome: R-HSA-438066;Reactome: R-HSA-399719;Reactome: R-HSA-6802955;Reactome: R-HSA-5576892;Reactome: R-HSA-6802952;Reactome: R-HSA-877300	"HSF1-dependent transactivation";"RAF/MAP kinase cascade";"CaMK IV-mediated phosphorylation of CREB";"Signaling by moderate kinase activity BRAF mutants";"Signaling downstream of RAS mutants";"Regulation of MECP2 expression and activity";"Long-term potentiation";"Ion transport by P-type ATPases";"Assembly and cell surface presentation of NMDA receptors";"RAF activation";"Ras activation upon Ca2+ influx through NMDA receptor";"Negative regulation of NMDA receptor-mediated neuronal transmission";"Ion homeostasis";"Unblocking of NMDA receptors, glutamate binding and activation";"Trafficking of AMPA receptors";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"Phase 0 - rapid depolarisation";"Signaling by BRAF and RAF fusions";"Interferon gamma signaling"
Medex_00002097-RA	1	Reactome: R-HSA-1799339	"SRP-dependent cotranslational protein targeting to membrane"
Medex_00069364-RA	1	Reactome: R-HSA-71064	"Lysine catabolism"
Medex_00007989-RA	1	Reactome: R-HSA-8951664	"Neddylation"
Medex_00085314-RA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Medex_00031768-RA	1	Reactome: R-HSA-8951664	"Neddylation"
Medex_00035549-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00016911-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Medex_00030793-RA	5	Reactome: R-HSA-198323;Reactome: R-HSA-166208;Reactome: R-HSA-165159;Reactome: R-HSA-3371571;Reactome: R-HSA-5674400	"AKT phosphorylates targets in the cytosol";"mTORC1-mediated signalling";"mTOR signalling";"HSF1-dependent transactivation";"Constitutive Signaling by AKT1 E17K in Cancer"
Medex_00059732-RA	1	Reactome: R-HSA-1632852	"Macroautophagy"
Medex_00077245-RA	4	Reactome: R-HSA-975871;Reactome: R-HSA-166058;Reactome: R-HSA-6799198;Reactome: R-HSA-975138	"MyD88 cascade initiated on plasma membrane";"MyD88:MAL(TIRAP) cascade initiated on plasma membrane";"Complex I biogenesis";"TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation"
Medex_00011955-RA	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
Medex_00030533-RA	2	Reactome: R-HSA-5357905;Reactome: R-HSA-5357956	"Regulation of TNFR1 signaling";"TNFR1-induced NFkappaB signaling pathway"
Medex_00006354-RA	57	Reactome: R-HSA-5607761;Reactome: R-HSA-5610780;Reactome: R-HSA-8852276;Reactome: R-HSA-174178;Reactome: R-HSA-5632684;Reactome: R-HSA-349425;Reactome: R-HSA-1236978;Reactome: R-HSA-180534;Reactome: R-HSA-5610785;Reactome: R-HSA-5689880;Reactome: R-HSA-5687128;Reactome: R-HSA-5668541;Reactome: R-HSA-5689603;Reactome: R-HSA-4608870;Reactome: R-HSA-8939902;Reactome: R-HSA-75815;Reactome: R-HSA-195253;Reactome: R-HSA-9010553;Reactome: R-HSA-211733;Reactome: R-HSA-68949;Reactome: R-HSA-8939236;Reactome: R-HSA-382556;Reactome: R-HSA-4641258;Reactome: R-HSA-2467813;Reactome: R-HSA-180585;Reactome: R-HSA-450408;Reactome: R-HSA-9020702;Reactome: R-HSA-6798695;Reactome: R-HSA-5658442;Reactome: R-HSA-5358346;Reactome: R-HSA-8941858;Reactome: R-HSA-983168;Reactome: R-HSA-202424;Reactome: R-HSA-8951664;Reactome: R-HSA-2871837;Reactome: R-HSA-1169091;Reactome: R-HSA-174154;Reactome: R-HSA-5607764;Reactome: R-HSA-174184;Reactome: R-HSA-1234176;Reactome: R-HSA-69017;Reactome: R-HSA-69601;Reactome: R-HSA-5362768;Reactome: R-HSA-5676590;Reactome: R-HSA-9604323;Reactome: R-HSA-68827;Reactome: R-HSA-8948751;Reactome: R-HSA-350562;Reactome: R-HSA-5678895;Reactome: R-HSA-69481;Reactome: R-HSA-174113;Reactome: R-HSA-4641257;Reactome: R-HSA-5610783;Reactome: R-HSA-1236974;Reactome: R-HSA-8854050;Reactome: R-HSA-187577;Reactome: R-HSA-174084	"Dectin-1 mediated noncanonical NF-kB signaling";"Degradation of GLI1 by the proteasome";"The role of GTSE1 in G2/M progression after G2 checkpoint";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Hedgehog 'on' state";"Autodegradation of the E3 ubiquitin ligase COP1";"Cross-presentation of soluble exogenous antigens (endosomes)";"Vpu mediated degradation of CD4";"GLI3 is processed to GLI3R by the proteasome";"Ub-specific processing proteases";"MAPK6/MAPK4 signaling";"TNFR2 non-canonical NF-kB pathway";"UCH proteinases";"Asymmetric localization of PCP proteins";"Regulation of RUNX2 expression and activity";"Ubiquitin-dependent degradation of Cyclin D";"Degradation of beta-catenin by the destruction complex";"Regulation of expression of SLITs and ROBOs";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Orc1 removal from chromatin";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"ABC-family proteins mediated transport";"Degradation of DVL";"Separation of Sister Chromatids";"Vif-mediated degradation of APOBEC3G";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Interleukin-1 signaling";"Neutrophil degranulation";"Regulation of RAS by GAPs";"Hedgehog ligand biogenesis";"Regulation of RUNX3 expression and activity";"Antigen processing: Ubiquitination & Proteasome degradation";"Downstream TCR signaling";"Neddylation";"FCERI mediated NF-kB activation";"Activation of NF-kappaB in B cells";"APC/C:Cdc20 mediated degradation of Securin";"CLEC7A (Dectin-1) signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"CDK-mediated phosphorylation and removal of Cdc6";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"NIK-->noncanonical NF-kB signaling";"Negative regulation of NOTCH4 signaling";"CDT1 association with the CDC6:ORC:origin complex";"Regulation of PTEN stability and activity";"Regulation of ornithine decarboxylase (ODC)";"Defective CFTR causes cystic fibrosis";"G2/M Checkpoints";"SCF-beta-TrCP mediated degradation of Emi1";"Degradation of AXIN";"Degradation of GLI2 by the proteasome";"ER-Phagosome pathway";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"SCF(Skp2)-mediated degradation of p27/p21";"Autodegradation of Cdh1 by Cdh1:APC/C"
Medex_00030651-RA	2	KEGG: 00510+3.6.1.43;Reactome: R-HSA-446199	"N-Glycan biosynthesis";"Synthesis of Dolichyl-phosphate"
Medex_00050059-RA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00041610-RA	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
Medex_00074048-RA	1	Reactome: R-HSA-9037629	"Lewis blood group biosynthesis"
Medex_00039126-RA	13	MetaCyc: PWY-6842;KEGG: 00053+1.8.5.1;MetaCyc: PWY-7533;KEGG: 00983+2.5.1.18;KEGG: 00982+2.5.1.18;MetaCyc: PWY-2261;KEGG: 00480+2.5.1.18+1.8.5.1;Reactome: R-HSA-196836;KEGG: 00980+2.5.1.18;MetaCyc: PWY-7112;MetaCyc: PWY-6370;MetaCyc: PWY-4061;Reactome: R-HSA-156590	"Glutathione-mediated detoxification II";"Ascorbate and aldarate metabolism";"Gliotoxin biosynthesis";"Drug metabolism - other enzymes";"Drug metabolism - cytochrome P450";"Ascorbate glutathione cycle";"Glutathione metabolism";"Vitamin C (ascorbate) metabolism";"Metabolism of xenobiotics by cytochrome P450";"4-hydroxy-2-nonenal detoxification";"Ascorbate recycling (cytosolic)";"Glutathione-mediated detoxification I";"Glutathione conjugation"
Medex_00075550-RA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
Medex_00053372-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Medex_00101291-RA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Medex_00086674-RA	3	Reactome: R-HSA-5423646;MetaCyc: PWY-7533;Reactome: R-HSA-2142691	"Aflatoxin activation and detoxification";"Gliotoxin biosynthesis";"Synthesis of Leukotrienes (LT) and Eoxins (EX)"
Medex_00039981-RA	1	Reactome: R-HSA-216083	"Integrin cell surface interactions"
Medex_00075283-RA	2	KEGG: 00480+1.11.1.15;Reactome: R-HSA-3299685	"Glutathione metabolism";"Detoxification of Reactive Oxygen Species"
Medex_00001469-RA	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840	"Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation"
Medex_00061471-RA	16	Reactome: R-HSA-69017;Reactome: R-HSA-176407;Reactome: R-HSA-174178;Reactome: R-HSA-176412;Reactome: R-HSA-8853884;Reactome: R-HSA-174154;Reactome: R-HSA-174184;Reactome: R-HSA-2559582;Reactome: R-HSA-174084;Reactome: R-HSA-141430;Reactome: R-HSA-983168;Reactome: R-HSA-176408;Reactome: R-HSA-174048;Reactome: R-HSA-2467813;Reactome: R-HSA-176409;Reactome: R-HSA-179409	"CDK-mediated phosphorylation and removal of Cdc6";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Phosphorylation of the APC/C";"Transcriptional Regulation by VENTX";"APC/C:Cdc20 mediated degradation of Securin";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Senescence-Associated Secretory Phenotype (SASP)";"Autodegradation of Cdh1 by Cdh1:APC/C";"Inactivation of APC/C via direct inhibition of the APC/C complex";"Antigen processing: Ubiquitination & Proteasome degradation";"Regulation of APC/C activators between G1/S and early anaphase";"APC/C:Cdc20 mediated degradation of Cyclin B";"Separation of Sister Chromatids";"APC/C:Cdc20 mediated degradation of mitotic proteins";"APC-Cdc20 mediated degradation of Nek2A"
Medex_00062371-RA	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5419276;Reactome: R-HSA-5368286	"Mitochondrial translation elongation";"Mitochondrial translation termination";"Mitochondrial translation initiation"
Medex_00045184-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Medex_00017297-RA	6	KEGG: 00600+3.2.1.23;KEGG: 00511+3.2.1.23;MetaCyc: PWY-6807;KEGG: 00604+3.2.1.23;KEGG: 00052+3.2.1.23;KEGG: 00531+3.2.1.23	"Sphingolipid metabolism";"Other glycan degradation";"Xyloglucan degradation II (exoglucanase)";"Glycosphingolipid biosynthesis - ganglio series";"Galactose metabolism";"Glycosaminoglycan degradation"
Medex_00094993-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Medex_00092796-RA	25	Reactome: R-HSA-8964616;Reactome: R-HSA-392170;Reactome: R-HSA-500657;Reactome: R-HSA-418594;Reactome: R-HSA-416476;Reactome: R-HSA-418597;Reactome: R-HSA-456926;Reactome: R-HSA-416482;Reactome: R-HSA-381676;Reactome: R-HSA-8964315;Reactome: R-HSA-418217;Reactome: R-HSA-4086398;Reactome: R-HSA-163359;Reactome: R-HSA-418555;Reactome: R-HSA-392851;Reactome: R-HSA-400042;Reactome: R-HSA-392451;Reactome: R-HSA-202040;Reactome: R-HSA-432040;Reactome: R-HSA-381771;Reactome: R-HSA-420092;Reactome: R-HSA-428930;Reactome: R-HSA-418592;Reactome: R-HSA-6814122;Reactome: R-HSA-9009391	"G beta:gamma signalling through CDC42";"ADP signalling through P2Y purinoceptor 12";"Presynaptic function of Kainate receptors";"G alpha (i) signalling events";"G alpha (q) signalling events";"G alpha (z) signalling events";"Thrombin signalling through proteinase activated receptors (PARs)";"G alpha (12/13) signalling events";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"G beta:gamma signalling through BTK";"G beta:gamma signalling through PLC beta";"Ca2+ pathway";"Glucagon signaling in metabolic regulation";"G alpha (s) signalling events";"Prostacyclin signalling through prostacyclin receptor";"Adrenaline,noradrenaline inhibits insulin secretion";"G beta:gamma signalling through PI3Kgamma";"G-protein activation";"Vasopressin regulates renal water homeostasis via Aquaporins";"Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)";"Glucagon-type ligand receptors";"Thromboxane signalling through TP receptor";"ADP signalling through P2Y purinoceptor 1";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"Extra-nuclear estrogen signaling"
Medex_00053368-RA	3	Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-212436	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"Generic Transcription Pathway"
Medex_00069016-RA	3	KEGG: 00860+1.3.3.3;Reactome: R-HSA-189451;MetaCyc: PWY-7159	"Porphyrin and chlorophyll metabolism";"Heme biosynthesis";"3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent)"
Medex_00019597-RA	24	Reactome: R-HSA-5626467;Reactome: R-HSA-2132295;Reactome: R-HSA-6807878;Reactome: R-HSA-9619483;Reactome: R-HSA-190840;Reactome: R-HSA-190861;Reactome: R-HSA-437239;Reactome: R-HSA-9609690;Reactome: R-HSA-6811436;Reactome: R-HSA-8955332;Reactome: R-HSA-8852276;Reactome: R-HSA-983189;Reactome: R-HSA-9609736;Reactome: R-HSA-2500257;Reactome: R-HSA-380320;Reactome: R-HSA-3371497;Reactome: R-HSA-5663220;Reactome: R-HSA-1445148;Reactome: R-HSA-68877;Reactome: R-HSA-6811434;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813;Reactome: R-HSA-5617833;Reactome: R-HSA-9646399	"RHO GTPases activate IQGAPs";"MHC class II antigen presentation";"COPI-mediated anterograde transport";"Activation of AMPK downstream of NMDARs";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Gap junction assembly";"Recycling pathway of L1";"HCMV Early Events";"COPI-independent Golgi-to-ER retrograde traffic";"Carboxyterminal post-translational modifications of tubulin";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Kinesins";"Assembly and cell surface presentation of NMDA receptors";"Resolution of Sister Chromatid Cohesion";"Recruitment of NuMA to mitotic centrosomes";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"RHO GTPases Activate Formins";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Mitotic Prometaphase";"COPI-dependent Golgi-to-ER retrograde traffic";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids";"Cilium Assembly";"Aggrephagy"
Medex_00019956-RA	1	Reactome: R-HSA-425561	"Sodium/Calcium exchangers"
Medex_00007724-RA	1	Reactome: R-HSA-6784531	"tRNA processing in the nucleus"
Medex_00032921-RA	1	Reactome: R-HSA-380320	"Recruitment of NuMA to mitotic centrosomes"
Medex_00098709-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Medex_00012855-RA	4	KEGG: 00230+6.3.4.4;KEGG: 00250+6.3.4.4;MetaCyc: PWY-7219;Reactome: R-HSA-73817	"Purine metabolism";"Alanine, aspartate and glutamate metabolism";"Adenosine ribonucleotides de novo biosynthesis";"Purine ribonucleoside monophosphate biosynthesis"
Medex_00046579-RA	6	Reactome: R-HSA-156827;Reactome: R-HSA-72695;Reactome: R-HSA-72702;Reactome: R-HSA-72649;Reactome: R-HSA-72689;Reactome: R-HSA-72706	"L13a-mediated translational silencing of Ceruloplasmin expression";"Formation of the ternary complex, and subsequently, the 43S complex";"Ribosomal scanning and start codon recognition";"Translation initiation complex formation";"Formation of a pool of free 40S subunits";"GTP hydrolysis and joining of the 60S ribosomal subunit"
Medex_00015208-RA	6	Reactome: R-HSA-380994;Reactome: R-HSA-450604;Reactome: R-HSA-450513;Reactome: R-HSA-450385;Reactome: R-HSA-429958;Reactome: R-HSA-6791226	"ATF4 activates genes in response to endoplasmic reticulum stress";"KSRP (KHSRP) binds and destabilizes mRNA";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"mRNA decay by 3' to 5' exoribonuclease";"Major pathway of rRNA processing in the nucleolus and cytosol"
Medex_00029704-RA	2	Reactome: R-HSA-8876198;Reactome: R-HSA-6811436	"RAB GEFs exchange GTP for GDP on RABs";"COPI-independent Golgi-to-ER retrograde traffic"
Medex_00083119-RA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
Medex_00029291-RA	1	Reactome: R-HSA-425381	"Bicarbonate transporters"
Medex_00037347-RA	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
Medex_00060926-RA	11	Reactome: R-HSA-163615;Reactome: R-HSA-170670;Reactome: R-HSA-163359;Reactome: R-HSA-418555;Reactome: R-HSA-164378;Reactome: R-HSA-170660;KEGG: 00230+4.6.1.1;Reactome: R-HSA-418594;Reactome: R-HSA-432040;Reactome: R-HSA-418597;Reactome: R-HSA-5610787	"PKA activation";"Adenylate cyclase inhibitory pathway";"Glucagon signaling in metabolic regulation";"G alpha (s) signalling events";"PKA activation in glucagon signalling";"Adenylate cyclase activating pathway";"Purine metabolism";"G alpha (i) signalling events";"Vasopressin regulates renal water homeostasis via Aquaporins";"G alpha (z) signalling events";"Hedgehog 'off' state"
Medex_00082176-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Medex_00035407-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Medex_00011630-RA	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5419276;Reactome: R-HSA-5389840	"Mitochondrial translation initiation";"Mitochondrial translation termination";"Mitochondrial translation elongation"
Medex_00037355-RA	3	Reactome: R-HSA-196807;Reactome: R-HSA-74259;Reactome: R-HSA-73621	"Nicotinate metabolism";"Purine catabolism";"Pyrimidine catabolism"
Medex_00067671-RA	2	Reactome: R-HSA-72165;Reactome: R-HSA-72163	"mRNA Splicing - Minor Pathway";"mRNA Splicing - Major Pathway"
Medex_00074508-RA	2	Reactome: R-HSA-390471;Reactome: R-HSA-1660662	"Association of TriC/CCT with target proteins during biosynthesis";"Glycosphingolipid metabolism"
Medex_00044093-RA	6	MetaCyc: PWY-5884;Reactome: R-HSA-9640463;MetaCyc: PWY-7656;MetaCyc: PWY-7782;MetaCyc: PWY-6733;KEGG: 00073+1.2.1.84	"Wax esters biosynthesis I";"Wax biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Plasmalogen biosynthesis";"Sporopollenin precursors biosynthesis";"Cutin, suberine and wax biosynthesis"
Medex_00046373-RA	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
Medex_00013482-RA	9	Reactome: R-HSA-68827;Reactome: R-HSA-113507;Reactome: R-HSA-68962;Reactome: R-HSA-176187;Reactome: R-HSA-68689;Reactome: R-HSA-68949;Reactome: R-HSA-68867;Reactome: R-HSA-68616;Reactome: R-HSA-69205	"CDT1 association with the CDC6:ORC:origin complex";"E2F-enabled inhibition of pre-replication complex formation";"Activation of the pre-replicative complex";"Activation of ATR in response to replication stress";"CDC6 association with the ORC:origin complex";"Orc1 removal from chromatin";"Assembly of the pre-replicative complex";"Assembly of the ORC complex at the origin of replication";"G1/S-Specific Transcription"
Medex_00068275-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Medex_00067768-RA	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
Medex_00090457-RA	1	Reactome: R-HSA-432047	"Passive transport by Aquaporins"
Medex_00064026-RA	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
Medex_00039536-RA	2	Reactome: R-HSA-1483191;Reactome: R-HSA-425366	"Synthesis of PC";"Transport of bile salts and organic acids, metal ions and amine compounds"
Medex_00073981-RA	1	Reactome: R-HSA-70221	"Glycogen breakdown (glycogenolysis)"
Medex_00038752-RA	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
Medex_00065660-RA	2	Reactome: R-HSA-3214858;Reactome: R-HSA-8939243	"RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"
Medex_00009472-RA	11	MetaCyc: PWY-8051;KEGG: 00561+3.1.3.4;MetaCyc: PWY-6453;MetaCyc: PWY-8053;MetaCyc: PWY-8052;MetaCyc: PWY-7782;KEGG: 00600+3.1.3.4;KEGG: 00564+3.1.3.4;MetaCyc: PWY-8055;Reactome: R-HSA-2029485;KEGG: 00565+3.1.3.4	"Anandamide biosynthesis I";"Glycerolipid metabolism";"Stigma estolide biosynthesis";"Anandamide biosynthesis II";"2-arachidonoylglycerol biosynthesis";"Plasmalogen biosynthesis";"Sphingolipid metabolism";"Glycerophospholipid metabolism";"Palmitoyl ethanolamide biosynthesis";"Role of phospholipids in phagocytosis";"Ether lipid metabolism"
Medex_00000218-RA	3	Reactome: R-HSA-202427;Reactome: R-HSA-6807004;Reactome: R-HSA-6798695	"Phosphorylation of CD3 and TCR zeta chains";"Negative regulation of MET activity";"Neutrophil degranulation"
Medex_00002066-RA	1	KEGG: 00480+3.4.11.2	"Glutathione metabolism"
Medex_00046874-RA	3	MetaCyc: PWY-5067;Reactome: R-HSA-3322077;KEGG: 00500+2.4.1.11	"Glycogen biosynthesis II (from UDP-D-Glucose)";"Glycogen synthesis";"Starch and sucrose metabolism"
Medex_00054453-RA	6	KEGG: 00030+3.1.1.17;MetaCyc: PWY-5530;KEGG: 00930+3.1.1.17;MetaCyc: PWY-7165;KEGG: 00053+3.1.1.17;MetaCyc: PWY-2221	"Pentose phosphate pathway";"Sorbitol biosynthesis II";"Caprolactam degradation";"L-ascorbate biosynthesis VI (engineered pathway)";"Ascorbate and aldarate metabolism";"Entner-Doudoroff pathway III (semi-phosphorylative)"
Medex_00093060-RA	2	Reactome: R-HSA-936837;Reactome: R-HSA-6798695	"Ion transport by P-type ATPases";"Neutrophil degranulation"
Medex_00037900-RA	7	MetaCyc: PWY-6840;Reactome: R-HSA-174403;MetaCyc: PWY-7255;MetaCyc: PWY-8043;KEGG: 00480+6.3.2.2;Reactome: R-HSA-5578999;KEGG: 00270+6.3.2.2	"Homoglutathione biosynthesis";"Glutathione synthesis and recycling";"Ergothioneine biosynthesis I (bacteria)";"Ophthalmate biosynthesis";"Glutathione metabolism";"Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD)";"Cysteine and methionine metabolism"
Medex_00012616-RA	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
Medex_00011392-RA	1	Reactome: R-HSA-8949613	"Cristae formation"
Medex_00014888-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Medex_00047496-RA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
Medex_00028633-RA	4	Reactome: R-HSA-6782315;KEGG: 00908+2.5.1.75;Reactome: R-HSA-6787450;MetaCyc: PWY-2781	"tRNA modification in the nucleus and cytosol";"Zeatin biosynthesis";"tRNA modification in the mitochondrion";"Cis-zeatin biosynthesis"
Medex_00017138-RA	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
Medex_00068551-RA	2	Reactome: R-HSA-70263;Reactome: R-HSA-70171	"Gluconeogenesis";"Glycolysis"
Medex_00018667-RA	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
Medex_00001871-RA	2	Reactome: R-HSA-5610787;Reactome: R-HSA-5620924	"Hedgehog 'off' state";"Intraflagellar transport"
Medex_00002108-RA	1	Reactome: R-HSA-1660662	"Glycosphingolipid metabolism"
Medex_00070511-RA	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
Medex_00076158-RA	3	KEGG: 00730+3.1.3.2;KEGG: 00740+3.1.3.2;MetaCyc: PWY-6348	"Thiamine metabolism";"Riboflavin metabolism";"Phosphate acquisition"
Medex_00032649-RA	3	Reactome: R-HSA-212436;Reactome: R-HSA-1989781;Reactome: R-HSA-381340	"Generic Transcription Pathway";"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation"
Medex_00046931-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Medex_00016478-RA	5	KEGG: 00010+4.1.1.32;MetaCyc: PWY-7383;KEGG: 00020+4.1.1.32;Reactome: R-HSA-70263;KEGG: 00620+4.1.1.32	"Glycolysis / Gluconeogenesis";"Anaerobic energy metabolism (invertebrates, cytosol)";"Citrate cycle (TCA cycle)";"Gluconeogenesis";"Pyruvate metabolism"
Medex_00076372-RA	24	Reactome: R-HSA-8852276;Reactome: R-HSA-983189;Reactome: R-HSA-9609736;Reactome: R-HSA-5626467;Reactome: R-HSA-2132295;Reactome: R-HSA-6807878;Reactome: R-HSA-437239;Reactome: R-HSA-190861;Reactome: R-HSA-190840;Reactome: R-HSA-9619483;Reactome: R-HSA-8955332;Reactome: R-HSA-6811436;Reactome: R-HSA-9609690;Reactome: R-HSA-9648025;Reactome: R-HSA-6811434;Reactome: R-HSA-68877;Reactome: R-HSA-2467813;Reactome: R-HSA-9646399;Reactome: R-HSA-5617833;Reactome: R-HSA-380320;Reactome: R-HSA-2500257;Reactome: R-HSA-3371497;Reactome: R-HSA-5663220;Reactome: R-HSA-1445148	"The role of GTSE1 in G2/M progression after G2 checkpoint";"Kinesins";"Assembly and cell surface presentation of NMDA receptors";"RHO GTPases activate IQGAPs";"MHC class II antigen presentation";"COPI-mediated anterograde transport";"Recycling pathway of L1";"Gap junction assembly";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Activation of AMPK downstream of NMDARs";"Carboxyterminal post-translational modifications of tubulin";"COPI-independent Golgi-to-ER retrograde traffic";"HCMV Early Events";"EML4 and NUDC in mitotic spindle formation";"COPI-dependent Golgi-to-ER retrograde traffic";"Mitotic Prometaphase";"Separation of Sister Chromatids";"Aggrephagy";"Cilium Assembly";"Recruitment of NuMA to mitotic centrosomes";"Resolution of Sister Chromatid Cohesion";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"RHO GTPases Activate Formins";"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
Medex_00003761-RA	6	Reactome: R-HSA-9609690;Reactome: R-HSA-3214815;Reactome: R-HSA-1989781;Reactome: R-HSA-9022537;Reactome: R-HSA-9022692;Reactome: R-HSA-9029569	"HCMV Early Events";"HDACs deacetylate histones";"PPARA activates gene expression";"Loss of MECP2 binding ability to the NCoR/SMRT complex";"Regulation of MECP2 expression and activity";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux"
Medex_00007281-RA	3	MetaCyc: PWY-3961;KEGG: 00770+2.7.1.33;Reactome: R-HSA-196783	"Phosphopantothenate biosynthesis II";"Pantothenate and CoA biosynthesis";"Coenzyme A biosynthesis"
Medex_00068725-RA	1	Reactome: R-HSA-191859	"snRNP Assembly"
Medex_00037296-RA	2	Reactome: R-HSA-379716;Reactome: R-HSA-2408522	"Cytosolic tRNA aminoacylation";"Selenoamino acid metabolism"
Medex_00032072-RA	3	Reactome: R-HSA-5620916;Reactome: R-HSA-264876;Reactome: R-HSA-1445148	"VxPx cargo-targeting to cilium";"Insulin processing";"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
Medex_00056442-RA	2	Reactome: R-HSA-6811434;Reactome: R-HSA-6807878	"COPI-dependent Golgi-to-ER retrograde traffic";"COPI-mediated anterograde transport"
Medex_00034016-RA	2	Reactome: R-HSA-380320;Reactome: R-HSA-380270	"Recruitment of NuMA to mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes"
Medex_00057223-RA	2	Reactome: R-HSA-390471;Reactome: R-HSA-1660662	"Association of TriC/CCT with target proteins during biosynthesis";"Glycosphingolipid metabolism"
Medex_00046407-RA	1	Reactome: R-HSA-211981	"Xenobiotics"
Medex_00006434-RA	3	KEGG: 00500+2.4.1.11;MetaCyc: PWY-5067;Reactome: R-HSA-3322077	"Starch and sucrose metabolism";"Glycogen biosynthesis II (from UDP-D-Glucose)";"Glycogen synthesis"
Medex_00087382-RA	3	Reactome: R-HSA-8963684;KEGG: 00643+1.13.11.5;KEGG: 00350+1.13.11.5	"Tyrosine catabolism";"Styrene degradation";"Tyrosine metabolism"
Medex_00060722-RA	2	Reactome: R-HSA-1296072;Reactome: R-HSA-5576894	"Voltage gated Potassium channels";"Phase 1 - inactivation of fast Na+ channels"
Medex_00046359-RA	3	Reactome: R-HSA-8950505;Reactome: R-HSA-72203;Reactome: R-HSA-72163	"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation";"Processing of Capped Intron-Containing Pre-mRNA";"mRNA Splicing - Major Pathway"
Medex_00032922-RA	1	Reactome: R-HSA-380320	"Recruitment of NuMA to mitotic centrosomes"
Medex_00021052-RA	2	KEGG: 00970+6.1.1.3;Reactome: R-HSA-114608	"Aminoacyl-tRNA biosynthesis";"Platelet degranulation"
Medex_00010590-RA	4	Reactome: R-HSA-2132295;Reactome: R-HSA-3371497;Reactome: R-HSA-6807878;Reactome: R-HSA-6811436	"MHC class II antigen presentation";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-mediated anterograde transport";"COPI-independent Golgi-to-ER retrograde traffic"
Medex_00018127-RA	1	Reactome: R-HSA-425986	"Sodium/Proton exchangers"
Medex_00015157-RA	7	Reactome: R-HSA-380320;Reactome: R-HSA-380270;Reactome: R-HSA-8854518;Reactome: R-HSA-380259;Reactome: R-HSA-2565942;Reactome: R-HSA-380284;Reactome: R-HSA-5620912	"Recruitment of NuMA to mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes";"AURKA Activation by TPX2";"Loss of Nlp from mitotic centrosomes";"Regulation of PLK1 Activity at G2/M Transition";"Loss of proteins required for interphase microtubule organization from the centrosome";"Anchoring of the basal body to the plasma membrane"
Medex_00025599-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Medex_00087899-RA	2	Reactome: R-HSA-8964038;Reactome: R-HSA-6798695	"LDL clearance";"Neutrophil degranulation"
Medex_00081980-RA	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
Medex_00062767-RA	1	Reactome: R-HSA-5693565	"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"
Medex_00017976-RA	2	Reactome: R-HSA-1660662;Reactome: R-HSA-390471	"Glycosphingolipid metabolism";"Association of TriC/CCT with target proteins during biosynthesis"
Medex_00083128-RA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
Medex_00037398-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Medex_00050856-RA	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
Medex_00001658-RA	19	MetaCyc: PWY-7337;MetaCyc: PWY-7574;KEGG: 00071+1.3.3.6;MetaCyc: PWY-7338;MetaCyc: PWY-7007;MetaCyc: PWY-5136;MetaCyc: PWY-7291;MetaCyc: PWY-7288;MetaCyc: PWY-6920;KEGG: 00410+1.3.3.6;MetaCyc: PWY-7854;MetaCyc: PWY-7726;KEGG: 00592+1.3.3.6;MetaCyc: PWY-735;MetaCyc: PWY-7606;MetaCyc: PWY-6837;MetaCyc: PWY-7858;KEGG: 00640+1.3.3.6;MetaCyc: PWY-7340	"10-cis-heptadecenoyl-CoA degradation (yeast)";"Propanoyl-coa degradation II";"Fatty acid degradation";"10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast)";"Methyl ketone biosynthesis (engineered)";"Fatty acid beta-oxidation II (plant peroxisome)";"Oleate beta-oxidation (isomerase-dependent, yeast)";"Fatty acid beta-oxidation VII (yeast peroxisome)";"6-gingerol analog biosynthesis (engineered)";"beta-Alanine metabolism";"Crotonyl-coa/ethylmalonyl-coa/hydroxybutyryl-coa cycle (engineered)";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"alpha-Linolenic acid metabolism";"Jasmonic acid biosynthesis";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Fatty acid beta-oxidation V (unsaturated, odd number, di-isomerase-dependent)";"(5Z)-dodecenoate biosynthesis II";"Propanoate metabolism";"9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast)"
Medex_00085502-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Medex_00060700-RA	1	Reactome: R-HSA-2132295	"MHC class II antigen presentation"
Medex_00087762-RA	1	Reactome: R-HSA-2151201	"Transcriptional activation of mitochondrial biogenesis"
Medex_00055929-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Medex_00014598-RA	6	KEGG: 00531+3.2.1.23;KEGG: 00052+3.2.1.23;KEGG: 00511+3.2.1.23;KEGG: 00600+3.2.1.23;MetaCyc: PWY-6807;KEGG: 00604+3.2.1.23	"Glycosaminoglycan degradation";"Galactose metabolism";"Other glycan degradation";"Sphingolipid metabolism";"Xyloglucan degradation II (exoglucanase)";"Glycosphingolipid biosynthesis - ganglio series"
Medex_00092316-RA	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
Medex_00010411-RA	2	KEGG: 00760+6.3.1.5;Reactome: R-HSA-196807	"Nicotinate and nicotinamide metabolism";"Nicotinate metabolism"
Medex_00023605-RA	4	Reactome: R-HSA-379716;KEGG: 00450+6.1.1.10;Reactome: R-HSA-2408522;KEGG: 00970+6.1.1.10	"Cytosolic tRNA aminoacylation";"Selenocompound metabolism";"Selenoamino acid metabolism";"Aminoacyl-tRNA biosynthesis"
Medex_00057254-RA	1	Reactome: R-HSA-197264	"Nicotinamide salvaging"
Medex_00012906-RA	1	Reactome: R-HSA-389661	"Glyoxylate metabolism and glycine degradation"
Medex_00086318-RA	1	Reactome: R-HSA-8951664	"Neddylation"
Medex_00023120-RA	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
Medex_00068605-RA	2	Reactome: R-HSA-72165;Reactome: R-HSA-72163	"mRNA Splicing - Minor Pathway";"mRNA Splicing - Major Pathway"
Medex_00048352-RA	10	Reactome: R-HSA-196025;Reactome: R-HSA-166016;Reactome: R-HSA-432722;Reactome: R-HSA-177504;Reactome: R-HSA-2132295;Reactome: R-HSA-432720;Reactome: R-HSA-203641;Reactome: R-HSA-190873;Reactome: R-HSA-8856828;Reactome: R-HSA-437239	"Formation of annular gap junctions";"Toll Like Receptor 4 (TLR4) Cascade";"Golgi Associated Vesicle Biogenesis";"Retrograde neurotrophin signalling";"MHC class II antigen presentation";"Lysosome Vesicle Biogenesis";"NOSTRIN mediated eNOS trafficking";"Gap junction degradation";"Clathrin-mediated endocytosis";"Recycling pathway of L1"
Medex_00081497-RA	1	Reactome: R-HSA-71288	"Creatine metabolism"
Medex_00051442-RA	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
Medex_00039871-RA	2	Reactome: R-HSA-901032;MetaCyc: PWY-7511	"ER Quality Control Compartment (ERQC)";"Protein ubiquitination"
Medex_00040147-RA	5	Reactome: R-HSA-2132295;Reactome: R-HSA-6798695;Reactome: R-HSA-1660662;Reactome: R-HSA-4085001;Reactome: R-HSA-4341670	"MHC class II antigen presentation";"Neutrophil degranulation";"Glycosphingolipid metabolism";"Sialic acid metabolism";"Defective NEU1 causes sialidosis"
Medex_00063165-RA	26	Reactome: R-HSA-5685942;Reactome: R-HSA-174437;Reactome: R-HSA-110312;Reactome: R-HSA-5696397;Reactome: R-HSA-5656121;Reactome: R-HSA-69205;Reactome: R-HSA-8866654;Reactome: R-HSA-5651801;Reactome: R-HSA-5696400;Reactome: R-HSA-5655862;Reactome: R-HSA-69183;Reactome: R-HSA-174411;Reactome: R-HSA-174414;Reactome: R-HSA-6804114;Reactome: R-HSA-69166;Reactome: R-HSA-1362277;Reactome: R-HSA-6782210;Reactome: R-HSA-174417;Reactome: R-HSA-69091;Reactome: R-HSA-110320;Reactome: R-HSA-5656169;Reactome: R-HSA-5358565;Reactome: R-HSA-110314;Reactome: R-HSA-4615885;Reactome: R-HSA-6782135;Reactome: R-HSA-5358606	"HDR through Homologous Recombination (HRR)";"Removal of the Flap Intermediate from the C-strand";"Translesion synthesis by REV1";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Translesion synthesis by POLI";"G1/S-Specific Transcription";"E3 ubiquitin ligases ubiquitinate target proteins";"PCNA-Dependent Long Patch Base Excision Repair";"Dual Incision in GG-NER";"Translesion synthesis by POLK";"Processive synthesis on the lagging strand";"Polymerase switching on the C-strand of the telomere";"Processive synthesis on the C-strand of the telomere";"TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest";"Removal of the Flap Intermediate";"Transcription of E2F targets under negative control by DREAM complex";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Telomere C-strand (Lagging Strand) Synthesis";"Polymerase switching";"Translesion Synthesis by POLH";"Termination of translesion DNA synthesis";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"Recognition of DNA damage by PCNA-containing replication complex";"SUMOylation of DNA replication proteins";"Dual incision in TC-NER";"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)"
Medex_00101629-RA	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
Medex_00026284-RA	6	KEGG: 00500+2.4.1.18;MetaCyc: PWY-5067;MetaCyc: PWY-7900;KEGG: 00500+3.2.1.1;Reactome: R-HSA-189085;MetaCyc: PWY-622	"Starch and sucrose metabolism";"Glycogen biosynthesis II (from UDP-D-Glucose)";"Glycogen biosynthesis III (from alpha-maltose 1-phosphate)";"Starch and sucrose metabolism";"Digestion of dietary carbohydrate";"Starch biosynthesis"
Medex_00064066-RA	6	Reactome: R-HSA-9615017;Reactome: R-HSA-3299685;KEGG: 00380+1.11.1.6;KEGG: 00630+1.11.1.6;Reactome: R-HSA-9033241;Reactome: R-HSA-6798695	"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"Detoxification of Reactive Oxygen Species";"Tryptophan metabolism";"Glyoxylate and dicarboxylate metabolism";"Peroxisomal protein import";"Neutrophil degranulation"
Medex_00055979-RA	16	Reactome: R-HSA-6791226;Reactome: R-HSA-72702;Reactome: R-HSA-72764;Reactome: R-HSA-72706;Reactome: R-HSA-975956;Reactome: R-HSA-9633012;Reactome: R-HSA-1799339;Reactome: R-HSA-975957;Reactome: R-HSA-2408557;Reactome: R-HSA-72689;Reactome: R-HSA-72695;Reactome: R-HSA-156902;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-72649;Reactome: R-HSA-192823	"Major pathway of rRNA processing in the nucleolus and cytosol";"Ribosomal scanning and start codon recognition";"Eukaryotic Translation Termination";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Selenocysteine synthesis";"Formation of a pool of free 40S subunits";"Formation of the ternary complex, and subsequently, the 43S complex";"Peptide chain elongation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Translation initiation complex formation";"Viral mRNA Translation"
Medex_00071934-RA	11	KEGG: 04660+2.7.10.2;Reactome: R-HSA-428890;Reactome: R-HSA-5685938;Reactome: R-HSA-8939236;Reactome: R-HSA-983231;Reactome: R-HSA-69231;Reactome: R-HSA-5663213;Reactome: R-HSA-2029482;Reactome: R-HSA-525793;Reactome: R-HSA-8940973;Reactome: R-HSA-5693565	"T cell receptor signaling pathway";"Role of ABL in ROBO-SLIT signaling";"HDR through Single Strand Annealing (SSA)";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Factors involved in megakaryocyte development and platelet production";"Cyclin D associated events in G1";"RHO GTPases Activate WASPs and WAVEs";"Regulation of actin dynamics for phagocytic cup formation";"Myogenesis";"RUNX2 regulates osteoblast differentiation";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"
Medex_00011993-RA	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
Medex_00084350-RA	3	Reactome: R-HSA-5578775;Reactome: R-HSA-936837;Reactome: R-HSA-418359	"Ion homeostasis";"Ion transport by P-type ATPases";"Reduction of cytosolic Ca++ levels"
Medex_00090558-RA	9	Reactome: R-HSA-68867;Reactome: R-HSA-68949;Reactome: R-HSA-68616;Reactome: R-HSA-69205;Reactome: R-HSA-68827;Reactome: R-HSA-68689;Reactome: R-HSA-176187;Reactome: R-HSA-68962;Reactome: R-HSA-113507	"Assembly of the pre-replicative complex";"Orc1 removal from chromatin";"Assembly of the ORC complex at the origin of replication";"G1/S-Specific Transcription";"CDT1 association with the CDC6:ORC:origin complex";"CDC6 association with the ORC:origin complex";"Activation of ATR in response to replication stress";"Activation of the pre-replicative complex";"E2F-enabled inhibition of pre-replication complex formation"
Medex_00006332-RA	2	KEGG: 00513+2.4.1.142;KEGG: 00510+2.4.1.142	"Various types of N-glycan biosynthesis";"N-Glycan biosynthesis"
Medex_00041317-RA	6	Reactome: R-HSA-68867;Reactome: R-HSA-68949;Reactome: R-HSA-69052;Reactome: R-HSA-176187;Reactome: R-HSA-68962;Reactome: R-HSA-176974	"Assembly of the pre-replicative complex";"Orc1 removal from chromatin";"Switching of origins to a post-replicative state";"Activation of ATR in response to replication stress";"Activation of the pre-replicative complex";"Unwinding of DNA"
Medex_00103502-RA	10	KEGG: 00261+2.7.7.4;KEGG: 00230+2.7.7.4;KEGG: 00450+2.7.7.4;MetaCyc: PWY-5340;MetaCyc: PWY-6683;Reactome: R-HSA-174362;MetaCyc: PWY-5278;KEGG: 00920+2.7.7.4;MetaCyc: PWY-6932;Reactome: R-HSA-2408550	"Monobactam biosynthesis";"Purine metabolism";"Selenocompound metabolism";"Sulfate activation for sulfonation";"Assimilatory sulfate reduction III";"Transport and synthesis of PAPS";"Sulfite oxidation III";"Sulfur metabolism";"Selenate reduction";"Metabolism of ingested H2SeO4 and H2SeO3 into H2Se"
Medex_00007753-RA	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00046043-RA	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
Medex_00033151-RA	1	Reactome: R-HSA-429947	"Deadenylation of mRNA"
Medex_00012694-RA	3	Reactome: R-HSA-76066;Reactome: R-HSA-749476;Reactome: R-HSA-76061	"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 1 Promoter"
Medex_00013769-RA	1	Reactome: R-HSA-425561	"Sodium/Calcium exchangers"
Medex_00015794-RA	1	Reactome: R-HSA-70895	"Branched-chain amino acid catabolism"
Medex_00002231-RA	2	Reactome: R-HSA-73614;Reactome: R-HSA-73621	"Pyrimidine salvage";"Pyrimidine catabolism"
Medex_00087662-RA	3	Reactome: R-HSA-1474228;Reactome: R-HSA-1442490;Reactome: R-HSA-1592389	"Degradation of the extracellular matrix";"Collagen degradation";"Activation of Matrix Metalloproteinases"
Medex_00074947-RA	13	Reactome: R-HSA-2408557;Reactome: R-HSA-6791226;Reactome: R-HSA-72706;Reactome: R-HSA-975956;Reactome: R-HSA-72764;Reactome: R-HSA-72689;Reactome: R-HSA-1799339;Reactome: R-HSA-156902;Reactome: R-HSA-9633012;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-975957;Reactome: R-HSA-192823	"Selenocysteine synthesis";"Major pathway of rRNA processing in the nucleolus and cytosol";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Formation of a pool of free 40S subunits";"SRP-dependent cotranslational protein targeting to membrane";"Peptide chain elongation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Viral mRNA Translation"
Medex_00071166-RA	2	Reactome: R-HSA-917729;Reactome: R-HSA-9610379	"Endosomal Sorting Complex Required For Transport (ESCRT)";"HCMV Late Events"
Medex_00077724-RA	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
Medex_00046087-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Medex_00064836-RA	1	Reactome: R-HSA-6809371	"Formation of the cornified envelope"
Medex_00042056-RA	1	Reactome: R-HSA-5676934	"Protein repair"
Medex_00087928-RA	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
Medex_00016195-RA	2	Reactome: R-HSA-1236974;Reactome: R-HSA-1799339	"ER-Phagosome pathway";"SRP-dependent cotranslational protein targeting to membrane"
Medex_00017071-RA	9	KEGG: 00513+3.2.1.52;MetaCyc: PWY-7822;KEGG: 00511+3.2.1.52;KEGG: 00604+3.2.1.52;KEGG: 00603+3.2.1.52;MetaCyc: PWY-7883;MetaCyc: PWY-6902;KEGG: 00520+3.2.1.52;KEGG: 00531+3.2.1.52	"Various types of N-glycan biosynthesis";"Chitin degradation III (Serratia)";"Other glycan degradation";"Glycosphingolipid biosynthesis - ganglio series";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Anhydromuropeptides recycling II";"Chitin degradation II (Vibrio)";"Amino sugar and nucleotide sugar metabolism";"Glycosaminoglycan degradation"
Medex_00056249-RA	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
Medex_00082915-RA	1	Reactome: R-HSA-6798163	"Choline catabolism"
Medex_00041046-RA	4	Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-6803157	"Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation";"Antimicrobial peptides"
Medex_00025869-RA	1	Reactome: R-HSA-1660661	"Sphingolipid de novo biosynthesis"
Medex_00005858-RA	2	MetaCyc: PWY-6788;KEGG: 00500+3.2.1.4	"Cellulose degradation II (fungi)";"Starch and sucrose metabolism"
Medex_00006836-RA	2	Reactome: R-HSA-68962;Reactome: R-HSA-176187	"Activation of the pre-replicative complex";"Activation of ATR in response to replication stress"
Medex_00031734-RA	2	Reactome: R-HSA-8963888;Reactome: R-HSA-8866423	"Chylomicron assembly";"VLDL assembly"
Medex_00020589-RA	5	Reactome: R-HSA-5625740;Reactome: R-HSA-75035;Reactome: R-HSA-5628897;Reactome: R-HSA-1445148;Reactome: R-HSA-111447	"RHO GTPases activate PKNs";"Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex";"TP53 Regulates Metabolic Genes";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Activation of BAD and translocation to mitochondria"
Medex_00013542-RA	8	MetaCyc: PWY-4983;MetaCyc: PWY-7400;MetaCyc: PWY-4984;Reactome: R-HSA-70635;KEGG: 00250+4.3.2.1;MetaCyc: PWY-5154;MetaCyc: PWY-5;KEGG: 00220+4.3.2.1	"Nitric oxide biosynthesis II (mammals)";"L-arginine biosynthesis IV (archaebacteria)";"Urea cycle";"Urea cycle";"Alanine, aspartate and glutamate metabolism";"L-arginine biosynthesis III (via N-acetyl-L-citrulline)";"Canavanine biosynthesis";"Arginine biosynthesis"
Medex_00008635-RA	10	Reactome: R-HSA-5607764;Reactome: R-HSA-1169091;Reactome: R-HSA-5684264;Reactome: R-HSA-8951664;Reactome: R-HSA-5607761;Reactome: R-HSA-2871837;Reactome: R-HSA-983168;Reactome: R-HSA-202424;Reactome: R-HSA-2565942;Reactome: R-HSA-5676590	"CLEC7A (Dectin-1) signaling";"Activation of NF-kappaB in B cells";"MAP3K8 (TPL2)-dependent MAPK1/3 activation";"Neddylation";"Dectin-1 mediated noncanonical NF-kB signaling";"FCERI mediated NF-kB activation";"Antigen processing: Ubiquitination & Proteasome degradation";"Downstream TCR signaling";"Regulation of PLK1 Activity at G2/M Transition";"NIK-->noncanonical NF-kB signaling"
Medex_00059946-RA	4	KEGG: 00380+1.2.4.2;KEGG: 00020+1.2.4.2;KEGG: 00310+1.2.4.2;MetaCyc: PWY-5084	"Tryptophan metabolism";"Citrate cycle (TCA cycle)";"Lysine degradation";"2-oxoglutarate decarboxylation to succinyl-CoA"
Medex_00021524-RA	2	Reactome: R-HSA-8866654;MetaCyc: PWY-7511	"E3 ubiquitin ligases ubiquitinate target proteins";"Protein ubiquitination"
Medex_00064957-RA	5	Reactome: R-HSA-5579006;MetaCyc: PWY-8043;KEGG: 00480+6.3.2.3;Reactome: R-HSA-174403;KEGG: 00270+6.3.2.3	"Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)";"Ophthalmate biosynthesis";"Glutathione metabolism";"Glutathione synthesis and recycling";"Cysteine and methionine metabolism"
Medex_00061097-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00030308-RA	2	Reactome: R-HSA-8963888;Reactome: R-HSA-8866423	"Chylomicron assembly";"VLDL assembly"
Medex_00102894-RA	1	Reactome: R-HSA-6798163	"Choline catabolism"
Medex_00054756-RA	1	Reactome: R-HSA-70221	"Glycogen breakdown (glycogenolysis)"
Medex_00057791-RA	19	Reactome: R-HSA-8866423;Reactome: R-HSA-8856825;Reactome: R-HSA-8964026;Reactome: R-HSA-5686938;Reactome: R-HSA-3000484;Reactome: R-HSA-8964046;Reactome: R-HSA-8964038;Reactome: R-HSA-432142;Reactome: R-HSA-975634;Reactome: R-HSA-8957275;Reactome: R-HSA-202733;Reactome: R-HSA-3000497;Reactome: R-HSA-381426;Reactome: R-HSA-3000471;Reactome: R-HSA-8856828;Reactome: R-HSA-3000480;Reactome: R-HSA-8963901;Reactome: R-HSA-8963888;Reactome: R-HSA-8964041	"VLDL assembly";"Cargo recognition for clathrin-mediated endocytosis";"Chylomicron clearance";"Regulation of TLR by endogenous ligand";"Scavenging by Class F Receptors";"VLDL clearance";"LDL clearance";"Platelet sensitization by LDL";"Retinoid metabolism and transport";"Post-translational protein phosphorylation";"Cell surface interactions at the vascular wall";"Scavenging by Class H Receptors";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"Scavenging by Class B Receptors";"Clathrin-mediated endocytosis";"Scavenging by Class A Receptors";"Chylomicron remodeling";"Chylomicron assembly";"LDL remodeling"
Medex_00001932-RA	14	Reactome: R-HSA-5696397;Reactome: R-HSA-5685942;Reactome: R-HSA-110312;Reactome: R-HSA-6782210;Reactome: R-HSA-5656121;Reactome: R-HSA-5651801;Reactome: R-HSA-5656169;Reactome: R-HSA-69091;Reactome: R-HSA-110320;Reactome: R-HSA-174411;Reactome: R-HSA-5655862;Reactome: R-HSA-110314;Reactome: R-HSA-6782135;Reactome: R-HSA-5696400	"Gap-filling DNA repair synthesis and ligation in GG-NER";"HDR through Homologous Recombination (HRR)";"Translesion synthesis by REV1";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Translesion synthesis by POLI";"PCNA-Dependent Long Patch Base Excision Repair";"Termination of translesion DNA synthesis";"Polymerase switching";"Translesion Synthesis by POLH";"Polymerase switching on the C-strand of the telomere";"Translesion synthesis by POLK";"Recognition of DNA damage by PCNA-containing replication complex";"Dual incision in TC-NER";"Dual Incision in GG-NER"
Medex_00035932-RA	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
Medex_00003225-RA	4	Reactome: R-HSA-382556;MetaCyc: PWY-6972;Reactome: R-HSA-5679001;Reactome: R-HSA-189483	"ABC-family proteins mediated transport";"Oleandomycin activation/inactivation";"Defective ABCC2 causes Dubin-Johnson syndrome";"Heme degradation"
Medex_00040514-RA	26	Reactome: R-HSA-5621575;Reactome: R-HSA-933541;Reactome: R-HSA-2894862;Reactome: R-HSA-3899300;Reactome: R-HSA-1368082;Reactome: R-HSA-9018519;Reactome: R-HSA-918233;Reactome: R-HSA-3371568;Reactome: R-HSA-5617472;Reactome: R-HSA-210744;Reactome: R-HSA-9013695;Reactome: R-HSA-2122947;Reactome: R-HSA-381340;Reactome: R-HSA-9614657;Reactome: R-HSA-8866907;Reactome: R-HSA-1234158;Reactome: R-HSA-9013508;Reactome: R-HSA-3214847;Reactome: R-HSA-201722;Reactome: R-HSA-1912408;Reactome: R-HSA-1989781;Reactome: R-HSA-400253;Reactome: R-HSA-3134973;Reactome: R-HSA-8941856;Reactome: R-HSA-2644606;Reactome: R-HSA-9617629	"CD209 (DC-SIGN) signaling";"TRAF6 mediated IRF7 activation";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"SUMOylation of transcription cofactors";"RORA activates gene expression";"Estrogen-dependent gene expression";"TRAF3-dependent IRF activation pathway";"Attenuation phase";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"NOTCH4 Intracellular Domain Regulates Transcription";"NOTCH1 Intracellular Domain Regulates Transcription";"Transcriptional regulation of white adipocyte differentiation";"FOXO-mediated transcription of cell death genes";"Activation of the TFAP2 (AP-2) family of transcription factors";"Regulation of gene expression by Hypoxia-inducible Factor";"NOTCH3 Intracellular Domain Regulates Transcription";"HATs acetylate histones";"Formation of the beta-catenin:TCF transactivating complex";"Pre-NOTCH Transcription and Translation";"PPARA activates gene expression";"Circadian Clock";"LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production";"RUNX3 regulates NOTCH signaling";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Regulation of FOXO transcriptional activity by acetylation"
Medex_00039924-RA	56	Reactome: R-HSA-5678895;Reactome: R-HSA-69481;Reactome: R-HSA-350562;Reactome: R-HSA-174113;Reactome: R-HSA-4641257;Reactome: R-HSA-69601;Reactome: R-HSA-5362768;Reactome: R-HSA-1234176;Reactome: R-HSA-69017;Reactome: R-HSA-5676590;Reactome: R-HSA-8948751;Reactome: R-HSA-9604323;Reactome: R-HSA-68827;Reactome: R-HSA-1169091;Reactome: R-HSA-174154;Reactome: R-HSA-5607764;Reactome: R-HSA-174184;Reactome: R-HSA-8951664;Reactome: R-HSA-2871837;Reactome: R-HSA-187577;Reactome: R-HSA-174084;Reactome: R-HSA-5610783;Reactome: R-HSA-1236974;Reactome: R-HSA-8854050;Reactome: R-HSA-8939902;Reactome: R-HSA-75815;Reactome: R-HSA-195253;Reactome: R-HSA-5689880;Reactome: R-HSA-5610785;Reactome: R-HSA-5668541;Reactome: R-HSA-5687128;Reactome: R-HSA-5689603;Reactome: R-HSA-4608870;Reactome: R-HSA-5632684;Reactome: R-HSA-1236978;Reactome: R-HSA-349425;Reactome: R-HSA-180534;Reactome: R-HSA-5607761;Reactome: R-HSA-8852276;Reactome: R-HSA-5610780;Reactome: R-HSA-174178;Reactome: R-HSA-5658442;Reactome: R-HSA-5358346;Reactome: R-HSA-8941858;Reactome: R-HSA-983168;Reactome: R-HSA-202424;Reactome: R-HSA-9020702;Reactome: R-HSA-4641258;Reactome: R-HSA-2467813;Reactome: R-HSA-180585;Reactome: R-HSA-450408;Reactome: R-HSA-9010553;Reactome: R-HSA-8939236;Reactome: R-HSA-211733;Reactome: R-HSA-68949;Reactome: R-HSA-382556	"Defective CFTR causes cystic fibrosis";"G2/M Checkpoints";"Regulation of ornithine decarboxylase (ODC)";"SCF-beta-TrCP mediated degradation of Emi1";"Degradation of AXIN";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"CDK-mediated phosphorylation and removal of Cdc6";"NIK-->noncanonical NF-kB signaling";"Regulation of PTEN stability and activity";"Negative regulation of NOTCH4 signaling";"CDT1 association with the CDC6:ORC:origin complex";"Activation of NF-kappaB in B cells";"APC/C:Cdc20 mediated degradation of Securin";"CLEC7A (Dectin-1) signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Neddylation";"FCERI mediated NF-kB activation";"SCF(Skp2)-mediated degradation of p27/p21";"Autodegradation of Cdh1 by Cdh1:APC/C";"Degradation of GLI2 by the proteasome";"ER-Phagosome pathway";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Regulation of RUNX2 expression and activity";"Ubiquitin-dependent degradation of Cyclin D";"Degradation of beta-catenin by the destruction complex";"Ub-specific processing proteases";"GLI3 is processed to GLI3R by the proteasome";"TNFR2 non-canonical NF-kB pathway";"MAPK6/MAPK4 signaling";"UCH proteinases";"Asymmetric localization of PCP proteins";"Hedgehog 'on' state";"Cross-presentation of soluble exogenous antigens (endosomes)";"Autodegradation of the E3 ubiquitin ligase COP1";"Vpu mediated degradation of CD4";"Dectin-1 mediated noncanonical NF-kB signaling";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Degradation of GLI1 by the proteasome";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Regulation of RAS by GAPs";"Hedgehog ligand biogenesis";"Regulation of RUNX3 expression and activity";"Antigen processing: Ubiquitination & Proteasome degradation";"Downstream TCR signaling";"Interleukin-1 signaling";"Degradation of DVL";"Separation of Sister Chromatids";"Vif-mediated degradation of APOBEC3G";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Regulation of expression of SLITs and ROBOs";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Orc1 removal from chromatin";"ABC-family proteins mediated transport"
Medex_00025273-RA	3	Reactome: R-HSA-193681;Reactome: R-HSA-5626978;Reactome: R-HSA-1660662	"Ceramide signalling";"TNFR1-mediated ceramide production";"Glycosphingolipid metabolism"
Medex_00071820-RA	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00010412-RA	2	KEGG: 00760+6.3.1.5;Reactome: R-HSA-196807	"Nicotinate and nicotinamide metabolism";"Nicotinate metabolism"
Medex_00005128-RA	2	Reactome: R-HSA-975957;Reactome: R-HSA-9010553	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs"
Medex_00089215-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00047724-RA	7	Reactome: R-HSA-5689880;Reactome: R-HSA-606279;Reactome: R-HSA-5689603;Reactome: R-HSA-201722;Reactome: R-HSA-3214847;Reactome: R-HSA-171319;Reactome: R-HSA-5696394	"Ub-specific processing proteases";"Deposition of new CENPA-containing nucleosomes at the centromere";"UCH proteinases";"Formation of the beta-catenin:TCF transactivating complex";"HATs acetylate histones";"Telomere Extension By Telomerase";"DNA Damage Recognition in GG-NER"
Medex_00034017-RA	2	Reactome: R-HSA-380320;Reactome: R-HSA-380270	"Recruitment of NuMA to mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes"
Medex_00061529-RA	8	MetaCyc: PWY-5;MetaCyc: PWY-5154;KEGG: 00220+6.3.4.5;MetaCyc: PWY-4983;KEGG: 00250+6.3.4.5;MetaCyc: PWY-4984;Reactome: R-HSA-70635;MetaCyc: PWY-7400	"Canavanine biosynthesis";"L-arginine biosynthesis III (via N-acetyl-L-citrulline)";"Arginine biosynthesis";"Nitric oxide biosynthesis II (mammals)";"Alanine, aspartate and glutamate metabolism";"Urea cycle";"Urea cycle";"L-arginine biosynthesis IV (archaebacteria)"
Medex_00044439-RA	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
Medex_00054544-RA	2	Reactome: R-HSA-5693568;Reactome: R-HSA-6783310	"Resolution of D-loop Structures through Holliday Junction Intermediates";"Fanconi Anemia Pathway"
Medex_00094033-RA	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
Medex_00037493-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00016960-RA	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
Medex_00092959-RA	1	Reactome: R-HSA-111465	"Apoptotic cleavage of cellular proteins"
Medex_00036489-RA	1	Reactome: R-HSA-203615	"eNOS activation"
Medex_00089899-RA	1	Reactome: R-HSA-9022692	"Regulation of MECP2 expression and activity"
Medex_00035619-RA	1	Reactome: R-HSA-611105	"Respiratory electron transport"
Medex_00020198-RA	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
Medex_00005438-RA	1	Reactome: R-HSA-1632852	"Macroautophagy"
Medex_00103194-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Medex_00077761-RA	1	KEGG: 00970+6.1.1.3	"Aminoacyl-tRNA biosynthesis"
Medex_00019624-RA	4	MetaCyc: PWY-7219;Reactome: R-HSA-499943;KEGG: 00730+2.7.4.3;KEGG: 00230+2.7.4.3	"Adenosine ribonucleotides de novo biosynthesis";"Interconversion of nucleotide di- and triphosphates";"Thiamine metabolism";"Purine metabolism"
Medex_00029719-RA	2	Reactome: R-HSA-917729;Reactome: R-HSA-162588	"Endosomal Sorting Complex Required For Transport (ESCRT)";"Budding and maturation of HIV virion"
Medex_00019887-RA	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
Medex_00087170-RA	2	Reactome: R-HSA-975577;Reactome: R-HSA-2022854	"N-Glycan antennae elongation";"Keratan sulfate biosynthesis"
Medex_00029853-RA	29	Reactome: R-HSA-6796648;Reactome: R-HSA-5696400;Reactome: R-HSA-72086;Reactome: R-HSA-73779;Reactome: R-HSA-112382;Reactome: R-HSA-77075;Reactome: R-HSA-427413;Reactome: R-HSA-167158;Reactome: R-HSA-5696395;Reactome: R-HSA-75953;Reactome: R-HSA-6781827;Reactome: R-HSA-167161;Reactome: R-HSA-73762;Reactome: R-HSA-113418;Reactome: R-HSA-6782135;Reactome: R-HSA-76042;Reactome: R-HSA-167162;Reactome: R-HSA-75955;Reactome: R-HSA-167246;Reactome: R-HSA-167160;Reactome: R-HSA-167200;Reactome: R-HSA-73772;Reactome: R-HSA-167172;Reactome: R-HSA-6781823;Reactome: R-HSA-6782210;Reactome: R-HSA-73776;Reactome: R-HSA-674695;Reactome: R-HSA-167152;Reactome: R-HSA-73863	"TP53 Regulates Transcription of DNA Repair Genes";"Dual Incision in GG-NER";"mRNA Capping";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Formation of RNA Pol II elongation complex";"RNA Pol II CTD phosphorylation and interaction with CE";"NoRC negatively regulates rRNA expression";"Formation of the HIV-1 Early Elongation Complex";"Formation of Incision Complex in GG-NER";"RNA Polymerase II Transcription Initiation";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"HIV Transcription Initiation";"RNA Polymerase I Transcription Initiation";"Formation of the Early Elongation Complex";"Dual incision in TC-NER";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Elongation";"Tat-mediated elongation of the HIV-1 transcript";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Polymerase I Promoter Escape";"Transcription of the HIV genome";"Formation of TC-NER Pre-Incision Complex";"Gap-filling DNA repair synthesis and ligation in TC-NER";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Pre-transcription Events";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Polymerase I Transcription Termination"
Medex_00047169-RA	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
Medex_00036175-RA	1	KEGG: 00290+4.2.1.33	"Valine, leucine and isoleucine biosynthesis"
Medex_00073218-RA	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
Medex_00005378-RA	1	Reactome: R-HSA-8951664	"Neddylation"
Medex_00077985-RA	5	Reactome: R-HSA-159231;Reactome: R-HSA-72163;Reactome: R-HSA-77595;Reactome: R-HSA-73856;Reactome: R-HSA-72187	"Transport of Mature mRNA Derived from an Intronless Transcript";"mRNA Splicing - Major Pathway";"Processing of Intronless Pre-mRNAs";"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing"
Medex_00079776-RA	6	Reactome: R-HSA-72689;Reactome: R-HSA-72706;Reactome: R-HSA-72695;Reactome: R-HSA-156827;Reactome: R-HSA-72649;Reactome: R-HSA-72702	"Formation of a pool of free 40S subunits";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Formation of the ternary complex, and subsequently, the 43S complex";"L13a-mediated translational silencing of Ceruloplasmin expression";"Translation initiation complex formation";"Ribosomal scanning and start codon recognition"
Medex_00069943-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00030133-RA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
Medex_00016962-RA	1	Reactome: R-HSA-389957	"Prefoldin mediated transfer of substrate to CCT/TriC"
Medex_00002589-RA	1	Reactome: R-HSA-5610787	"Hedgehog 'off' state"
Medex_00082419-RA	1	Reactome: R-HSA-69231	"Cyclin D associated events in G1"
Medex_00043144-RA	2	Reactome: R-HSA-5693568;Reactome: R-HSA-6783310	"Resolution of D-loop Structures through Holliday Junction Intermediates";"Fanconi Anemia Pathway"
Medex_00006785-RA	4	KEGG: 00520+3.2.1.14;MetaCyc: PWY-7822;MetaCyc: PWY-6855;MetaCyc: PWY-6902	"Amino sugar and nucleotide sugar metabolism";"Chitin degradation III (Serratia)";"Chitin degradation I (archaea)";"Chitin degradation II (Vibrio)"
Medex_00098518-RA	4	Reactome: R-HSA-9614399;Reactome: R-HSA-5674400;Reactome: R-HSA-9615017;Reactome: R-HSA-198693	"Regulation of localization of FOXO transcription factors";"Constitutive Signaling by AKT1 E17K in Cancer";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"AKT phosphorylates targets in the nucleus"
Medex_00034741-RA	5	Reactome: R-HSA-6798695;Reactome: R-HSA-2132295;Reactome: R-HSA-4341670;Reactome: R-HSA-4085001;Reactome: R-HSA-1660662	"Neutrophil degranulation";"MHC class II antigen presentation";"Defective NEU1 causes sialidosis";"Sialic acid metabolism";"Glycosphingolipid metabolism"
Medex_00054961-RA	3	KEGG: 00730+3.1.3.2;KEGG: 00740+3.1.3.2;MetaCyc: PWY-6348	"Thiamine metabolism";"Riboflavin metabolism";"Phosphate acquisition"
Medex_00009741-RA	3	Reactome: R-HSA-174403;MetaCyc: PWY-7942;KEGG: 00480+4.3.2.7	"Glutathione synthesis and recycling";"5-oxo-L-proline metabolism";"Glutathione metabolism"
Medex_00091600-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00011896-RA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Medex_00031721-RA	33	Reactome: R-HSA-141444;Reactome: R-HSA-168325;Reactome: R-HSA-191859;Reactome: R-HSA-4551638;Reactome: R-HSA-170822;Reactome: R-HSA-168271;Reactome: R-HSA-3232142;Reactome: R-HSA-159230;Reactome: R-HSA-5663220;Reactome: R-HSA-9648025;Reactome: R-HSA-159231;Reactome: R-HSA-68877;Reactome: R-HSA-159227;Reactome: R-HSA-1169408;Reactome: R-HSA-2467813;Reactome: R-HSA-168333;Reactome: R-HSA-3108214;Reactome: R-HSA-6784531;Reactome: R-HSA-159236;Reactome: R-HSA-9610379;Reactome: R-HSA-5619107;Reactome: R-HSA-9609690;Reactome: R-HSA-4085377;Reactome: R-HSA-4570464;Reactome: R-HSA-180910;Reactome: R-HSA-3301854;Reactome: R-HSA-2500257;Reactome: R-HSA-168276;Reactome: R-HSA-5578749;Reactome: R-HSA-4615885;Reactome: R-HSA-3371453;Reactome: R-HSA-180746;Reactome: R-HSA-165054	"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Viral Messenger RNA Synthesis";"snRNP Assembly";"SUMOylation of chromatin organization proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Transport of Ribonucleoproteins into the Host Nucleus";"SUMOylation of ubiquitinylation proteins";"Transport of the SLBP Dependant Mature mRNA";"RHO GTPases Activate Formins";"EML4 and NUDC in mitotic spindle formation";"Transport of Mature mRNA Derived from an Intronless Transcript";"Mitotic Prometaphase";"Transport of the SLBP independent Mature mRNA";"ISG15 antiviral mechanism";"Separation of Sister Chromatids";"NEP/NS2 Interacts with the Cellular Export Machinery";"SUMOylation of DNA damage response and repair proteins";"tRNA processing in the nucleus";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"HCMV Late Events";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"HCMV Early Events";"SUMOylation of SUMOylation proteins";"SUMOylation of RNA binding proteins";"Vpr-mediated nuclear import of PICs";"Nuclear Pore Complex (NPC) Disassembly";"Resolution of Sister Chromatid Cohesion";"NS1 Mediated Effects on Host Pathways";"Transcriptional regulation by small RNAs";"SUMOylation of DNA replication proteins";"Regulation of HSF1-mediated heat shock response";"Nuclear import of Rev protein";"Rev-mediated nuclear export of HIV RNA"
Medex_00066270-RA	2	Reactome: R-HSA-5218920;Reactome: R-HSA-418990	"VEGFR2 mediated vascular permeability";"Adherens junctions interactions"
Medex_00027920-RA	8	Reactome: R-HSA-983712;Reactome: R-HSA-77387;Reactome: R-HSA-9639288;Reactome: R-HSA-1222556;Reactome: R-HSA-917977;KEGG: 00195+7.1.2.2;KEGG: 00190+7.1.2.2;MetaCyc: PWY-7980	"Ion channel transport";"Insulin receptor recycling";"Amino acids regulate mTORC1";"ROS and RNS production in phagocytes";"Transferrin endocytosis and recycling";"Photosynthesis";"Oxidative phosphorylation";"ATP biosynthesis"
Medex_00008102-RA	6	Reactome: R-HSA-6791226;Reactome: R-HSA-429958;Reactome: R-HSA-450604;Reactome: R-HSA-450385;Reactome: R-HSA-450513;Reactome: R-HSA-380994	"Major pathway of rRNA processing in the nucleolus and cytosol";"mRNA decay by 3' to 5' exoribonuclease";"KSRP (KHSRP) binds and destabilizes mRNA";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"ATF4 activates genes in response to endoplasmic reticulum stress"
Medex_00094144-RA	1	Reactome: R-HSA-3295583	"TRP channels"
Medex_00051804-RA	1	KEGG: 00480+1.8.4.2	"Glutathione metabolism"
Medex_00064292-RA	14	Reactome: R-HSA-6782210;Reactome: R-HSA-5656121;Reactome: R-HSA-5685942;Reactome: R-HSA-110312;Reactome: R-HSA-5696397;Reactome: R-HSA-5696400;Reactome: R-HSA-174411;Reactome: R-HSA-5655862;Reactome: R-HSA-110314;Reactome: R-HSA-6782135;Reactome: R-HSA-5651801;Reactome: R-HSA-110320;Reactome: R-HSA-69091;Reactome: R-HSA-5656169	"Gap-filling DNA repair synthesis and ligation in TC-NER";"Translesion synthesis by POLI";"HDR through Homologous Recombination (HRR)";"Translesion synthesis by REV1";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Dual Incision in GG-NER";"Polymerase switching on the C-strand of the telomere";"Translesion synthesis by POLK";"Recognition of DNA damage by PCNA-containing replication complex";"Dual incision in TC-NER";"PCNA-Dependent Long Patch Base Excision Repair";"Translesion Synthesis by POLH";"Polymerase switching";"Termination of translesion DNA synthesis"
Medex_00017381-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Medex_00067940-RA	3	Reactome: R-HSA-8866654;Reactome: R-HSA-9603798;Reactome: R-HSA-9033241	"E3 ubiquitin ligases ubiquitinate target proteins";"Class I peroxisomal membrane protein import";"Peroxisomal protein import"
Medex_00041617-RA	10	MetaCyc: PWY-2201;MetaCyc: PWY-5497;KEGG: 00670+1.5.1.5+3.5.4.9;MetaCyc: PWY-7909;Reactome: R-HSA-196757;MetaCyc: PWY-5030;MetaCyc: PWY-6613;MetaCyc: PWY-3841;MetaCyc: PWY-1722;KEGG: 00720+1.5.1.5+3.5.4.9	"Folate transformations I";"Purine nucleobases degradation II (anaerobic)";"One carbon pool by folate";"Formaldehyde oxidation VII (THF pathway)";"Metabolism of folate and pterines";"L-histidine degradation III";"Tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate";"Folate transformations II (plants)";"Formate assimilation into 5,10-methylenetetrahydrofolate";"Carbon fixation pathways in prokaryotes"
Medex_00097615-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00091862-RA	4	Reactome: R-HSA-3214847;Reactome: R-HSA-5689603;KEGG: 00514+2.4.1.255;MetaCyc: PWY-7437	"HATs acetylate histones";"UCH proteinases";"Other types of O-glycan biosynthesis";"Protein O-[N-acetyl]-glucosylation"
Medex_00046186-RA	5	Reactome: R-HSA-8876198;Reactome: R-HSA-1445148;Reactome: R-HSA-8873719;Reactome: R-HSA-6798695;Reactome: R-HSA-1660499	"RAB GEFs exchange GTP for GDP on RABs";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"RAB geranylgeranylation";"Neutrophil degranulation";"Synthesis of PIPs at the plasma membrane"
Medex_00017805-RA	1	Reactome: R-HSA-1169408	"ISG15 antiviral mechanism"
Medex_00052116-RA	2	Reactome: R-HSA-3299685;MetaCyc: PWY-6854	"Detoxification of Reactive Oxygen Species";"Ethylene biosynthesis III (microbes)"
Medex_00013939-RA	1	Reactome: R-HSA-8876725	"Protein methylation"
Medex_00076538-RA	9	Reactome: R-HSA-76042;Reactome: R-HSA-167162;Reactome: R-HSA-73779;Reactome: R-HSA-73776;Reactome: R-HSA-6807505;Reactome: R-HSA-674695;Reactome: R-HSA-167172;Reactome: R-HSA-75953;Reactome: R-HSA-167161	"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase II Promoter Escape";"RNA polymerase II transcribes snRNA genes";"RNA Polymerase II Pre-transcription Events";"Transcription of the HIV genome";"RNA Polymerase II Transcription Initiation";"HIV Transcription Initiation"
Medex_00082817-RA	13	Reactome: R-HSA-975957;Reactome: R-HSA-192823;Reactome: R-HSA-1799339;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-156902;Reactome: R-HSA-9633012;Reactome: R-HSA-975956;Reactome: R-HSA-72706;Reactome: R-HSA-72689;Reactome: R-HSA-72764;Reactome: R-HSA-2408557;Reactome: R-HSA-6791226	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Viral mRNA Translation";"SRP-dependent cotranslational protein targeting to membrane";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Peptide chain elongation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Formation of a pool of free 40S subunits";"Eukaryotic Translation Termination";"Selenocysteine synthesis";"Major pathway of rRNA processing in the nucleolus and cytosol"
Medex_00010752-RA	1	Reactome: R-HSA-70921	"Histidine catabolism"
Medex_00082127-RA	2	Reactome: R-HSA-611105;Reactome: R-HSA-5628897	"Respiratory electron transport";"TP53 Regulates Metabolic Genes"
Medex_00054980-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Medex_00030490-RA	2	KEGG: 00480+1.11.1.15;Reactome: R-HSA-3299685	"Glutathione metabolism";"Detoxification of Reactive Oxygen Species"
Medex_00080010-RA	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
Medex_00035533-RA	8	KEGG: 00051+2.7.1.1;KEGG: 00010+2.7.1.1;KEGG: 00524+2.7.1.1;KEGG: 00500+2.7.1.1;KEGG: 00052+2.7.1.1;KEGG: 00521+2.7.1.1;Reactome: R-HSA-70171;KEGG: 00520+2.7.1.1	"Fructose and mannose metabolism";"Glycolysis / Gluconeogenesis";"Neomycin, kanamycin and gentamicin biosynthesis";"Starch and sucrose metabolism";"Galactose metabolism";"Streptomycin biosynthesis";"Glycolysis";"Amino sugar and nucleotide sugar metabolism"
Medex_00094255-RA	16	Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-72695;Reactome: R-HSA-156902;Reactome: R-HSA-72649;Reactome: R-HSA-192823;Reactome: R-HSA-2408557;Reactome: R-HSA-72689;Reactome: R-HSA-9633012;Reactome: R-HSA-1799339;Reactome: R-HSA-975957;Reactome: R-HSA-6791226;Reactome: R-HSA-72702;Reactome: R-HSA-72764;Reactome: R-HSA-975956;Reactome: R-HSA-72706	"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Formation of the ternary complex, and subsequently, the 43S complex";"Peptide chain elongation";"Translation initiation complex formation";"Viral mRNA Translation";"Selenocysteine synthesis";"Formation of a pool of free 40S subunits";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"Ribosomal scanning and start codon recognition";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit"
Medex_00078223-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Medex_00013129-RA	2	KEGG: 00520+2.4.1.16;MetaCyc: PWY-6981	"Amino sugar and nucleotide sugar metabolism";"Chitin biosynthesis"
Medex_00013175-RA	6	Reactome: R-HSA-3322077;MetaCyc: PWY-7900;KEGG: 00500+2.4.1.18;MetaCyc: PWY-5067;MetaCyc: PWY-622;Reactome: R-HSA-3878781	"Glycogen synthesis";"Glycogen biosynthesis III (from alpha-maltose 1-phosphate)";"Starch and sucrose metabolism";"Glycogen biosynthesis II (from UDP-D-Glucose)";"Starch biosynthesis";"Glycogen storage disease type IV (GBE1)"
Medex_00005103-RA	1	Reactome: R-HSA-419037	"NCAM1 interactions"
Medex_00032934-RA	1	Reactome: R-HSA-2151201	"Transcriptional activation of mitochondrial biogenesis"
Medex_00097727-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Medex_00022039-RA	1	Reactome: R-HSA-73621	"Pyrimidine catabolism"
Medex_00090907-RA	6	KEGG: 00600+3.2.1.23;KEGG: 00511+3.2.1.23;MetaCyc: PWY-6807;KEGG: 00604+3.2.1.23;KEGG: 00531+3.2.1.23;KEGG: 00052+3.2.1.23	"Sphingolipid metabolism";"Other glycan degradation";"Xyloglucan degradation II (exoglucanase)";"Glycosphingolipid biosynthesis - ganglio series";"Glycosaminoglycan degradation";"Galactose metabolism"
Medex_00075684-RA	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
Medex_00042715-RA	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840	"Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation"
Medex_00053791-RA	1	Reactome: R-HSA-432047	"Passive transport by Aquaporins"
Medex_00062320-RA	2	MetaCyc: PWY-6281;KEGG: 00450+2.7.9.3	"L-selenocysteine biosynthesis II (archaea and eukaryotes)";"Selenocompound metabolism"
Medex_00042188-RA	2	Reactome: R-HSA-380320;Reactome: R-HSA-380270	"Recruitment of NuMA to mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes"
Medex_00061879-RA	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
Medex_00023222-RA	4	Reactome: R-HSA-446193;KEGG: 00513+2.4.1.131;KEGG: 00510+2.4.1.131;Reactome: R-HSA-4551295	"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"Various types of N-glycan biosynthesis";"N-Glycan biosynthesis";"Defective ALG11 causes ALG11-CDG (CDG-1p)"
Medex_00000024-RA	5	Reactome: R-HSA-4341670;Reactome: R-HSA-4085001;Reactome: R-HSA-1660662;Reactome: R-HSA-6798695;Reactome: R-HSA-2132295	"Defective NEU1 causes sialidosis";"Sialic acid metabolism";"Glycosphingolipid metabolism";"Neutrophil degranulation";"MHC class II antigen presentation"
Medex_00013645-RA	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
Medex_00026535-RA	1	Reactome: R-HSA-6803157	"Antimicrobial peptides"
Medex_00072782-RA	2	Reactome: R-HSA-1660662;Reactome: R-HSA-390471	"Glycosphingolipid metabolism";"Association of TriC/CCT with target proteins during biosynthesis"
Medex_00077827-RA	2	Reactome: R-HSA-8939243;Reactome: R-HSA-3214858	"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RMTs methylate histone arginines"
Medex_00090284-RA	2	Reactome: R-HSA-611105;Reactome: R-HSA-5628897	"Respiratory electron transport";"TP53 Regulates Metabolic Genes"
Medex_00048388-RA	14	MetaCyc: PWY-7725;KEGG: 00062+2.3.1.199;MetaCyc: PWY-6598;MetaCyc: PWY-5080;MetaCyc: PWY-8041;MetaCyc: PWY-7724;MetaCyc: PWY-7601;MetaCyc: PWY-5972;MetaCyc: PWY-7035;Reactome: R-HSA-75876;MetaCyc: PWY-6433;MetaCyc: PWY-7602;MetaCyc: PWY-7619;MetaCyc: PWY-7036	"Arachidonate biosynthesis V (8-detaturase, mammals)";"Fatty acid elongation";"Sciadonate biosynthesis";"Very long chain fatty acid biosynthesis I";"Ultra-long-chain fatty acid biosynthesis";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Stearate biosynthesis I (animals)";"(9Z)-tricosene biosynthesis";"Synthesis of very long-chain fatty acyl-CoAs";"Hydroxylated fatty acid biosynthesis (plants)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Juniperonate biosynthesis";"Very long chain fatty acid biosynthesis II"
Medex_00007707-RA	4	Reactome: R-HSA-352230;Reactome: R-HSA-210991;Reactome: R-HSA-71240;Reactome: R-HSA-5660862	"Amino acid transport across the plasma membrane";"Basigin interactions";"Tryptophan catabolism";"Defective SLC7A7 causes lysinuric protein intolerance (LPI)"
Medex_00016319-RA	2	Reactome: R-HSA-1660662;Reactome: R-HSA-390471	"Glycosphingolipid metabolism";"Association of TriC/CCT with target proteins during biosynthesis"
Medex_00078924-RA	1	Reactome: R-HSA-6798163	"Choline catabolism"
Medex_00022714-RA	1	Reactome: R-HSA-3299685	"Detoxification of Reactive Oxygen Species"
Medex_00045005-RA	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
Medex_00065955-RA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
Medex_00036388-RA	6	Reactome: R-HSA-381426;Reactome: R-HSA-8957275;Reactome: R-HSA-3769402;Reactome: R-HSA-2173796;Reactome: R-HSA-201722;Reactome: R-HSA-5626467	"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"Post-translational protein phosphorylation";"Deactivation of the beta-catenin transactivating complex";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"Formation of the beta-catenin:TCF transactivating complex";"RHO GTPases activate IQGAPs"
Medex_00085931-RA	5	KEGG: 00760+2.7.1.23;MetaCyc: PWY-7269;Reactome: R-HSA-196807;MetaCyc: PWY-7268;MetaCyc: PWY-5083	"Nicotinate and nicotinamide metabolism";"NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)";"Nicotinate metabolism";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"NAD/NADH phosphorylation and dephosphorylation"
Medex_00065557-RA	4	KEGG: 00230+2.7.4.3;KEGG: 00730+2.7.4.3;Reactome: R-HSA-499943;MetaCyc: PWY-7219	"Purine metabolism";"Thiamine metabolism";"Interconversion of nucleotide di- and triphosphates";"Adenosine ribonucleotides de novo biosynthesis"
Medex_00085962-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Medex_00020049-RA	2	Reactome: R-HSA-373080;Reactome: R-HSA-3238698	"Class B/2 (Secretin family receptors)";"WNT ligand biogenesis and trafficking"
Medex_00047635-RA	10	KEGG: 00562+2.7.1.134+2.7.1.159;MetaCyc: PWY-6366;MetaCyc: PWY-6554;MetaCyc: PWY-6365;MetaCyc: PWY-6362;Reactome: R-HSA-983231;Reactome: R-HSA-1855167;MetaCyc: PWY-4661;Reactome: R-HSA-1855204;KEGG: 04070+2.7.1.159	"Inositol phosphate metabolism";"D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis";"1D-myo-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3)";"D-myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis";"1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)";"Factors involved in megakaryocyte development and platelet production";"Synthesis of pyrophosphates in the cytosol";"1D-myo-inositol hexakisphosphate biosynthesis III (Spirodela polyrrhiza)";"Synthesis of IP3 and IP4 in the cytosol";"Phosphatidylinositol signaling system"
Medex_00086312-RA	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
Medex_00035405-RA	2	Reactome: R-HSA-390471;Reactome: R-HSA-1660662	"Association of TriC/CCT with target proteins during biosynthesis";"Glycosphingolipid metabolism"
Medex_00079306-RA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
Medex_00016117-RA	7	Reactome: R-HSA-72662;Reactome: R-HSA-429947;Reactome: R-HSA-72706;Reactome: R-HSA-156827;Reactome: R-HSA-72702;Reactome: R-HSA-166208;Reactome: R-HSA-72649	"Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S";"Deadenylation of mRNA";"GTP hydrolysis and joining of the 60S ribosomal subunit";"L13a-mediated translational silencing of Ceruloplasmin expression";"Ribosomal scanning and start codon recognition";"mTORC1-mediated signalling";"Translation initiation complex formation"
Medex_00078504-RA	1	Reactome: R-HSA-8951664	"Neddylation"
Medex_00053414-RA	1	Reactome: R-HSA-211981	"Xenobiotics"
Medex_00004770-RA	3	Reactome: R-HSA-948021;Reactome: R-HSA-204005;Reactome: R-HSA-5694530	"Transport to the Golgi and subsequent modification";"COPII-mediated vesicle transport";"Cargo concentration in the ER"
Medex_00055214-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Medex_00032975-RA	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
Medex_00078090-RA	2	Reactome: R-HSA-1660662;Reactome: R-HSA-390471	"Glycosphingolipid metabolism";"Association of TriC/CCT with target proteins during biosynthesis"
Medex_00012578-RA	1	KEGG: 00480+3.4.11.2	"Glutathione metabolism"
Medex_00088191-RA	4	Reactome: R-HSA-2022090;Reactome: R-HSA-8948216;Reactome: R-HSA-1442490;Reactome: R-HSA-1650814	"Assembly of collagen fibrils and other multimeric structures";"Collagen chain trimerization";"Collagen degradation";"Collagen biosynthesis and modifying enzymes"
Medex_00010500-RA	2	Reactome: R-HSA-8949613;Reactome: R-HSA-163210	"Cristae formation";"Formation of ATP by chemiosmotic coupling"
Medex_00061330-RA	2	Reactome: R-HSA-5689880;Reactome: R-HSA-5689896	"Ub-specific processing proteases";"Ovarian tumor domain proteases"
Medex_00088077-RA	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
Medex_00039143-RA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Medex_00001248-RA	2	KEGG: 00500+3.2.1.4;MetaCyc: PWY-6788	"Starch and sucrose metabolism";"Cellulose degradation II (fungi)"
Medex_00041038-RA	1	Reactome: R-HSA-432047	"Passive transport by Aquaporins"
Medex_00046120-RA	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
Medex_00086995-RA	7	MetaCyc: PWY-6367;KEGG: 04070+3.1.4.11;MetaCyc: PWY-8052;MetaCyc: PWY-7039;MetaCyc: PWY-6351;Reactome: R-HSA-1855204;KEGG: 00562+3.1.4.11	"D-myo-inositol-5-phosphate metabolism";"Phosphatidylinositol signaling system";"2-arachidonoylglycerol biosynthesis";"Phosphatidate metabolism, as a signaling molecule";"D-myo-inositol (1,4,5)-trisphosphate biosynthesis";"Synthesis of IP3 and IP4 in the cytosol";"Inositol phosphate metabolism"
Medex_00044037-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00102223-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00013480-RA	9	Reactome: R-HSA-68867;Reactome: R-HSA-68949;Reactome: R-HSA-69205;Reactome: R-HSA-68616;Reactome: R-HSA-68827;Reactome: R-HSA-176187;Reactome: R-HSA-68689;Reactome: R-HSA-68962;Reactome: R-HSA-113507	"Assembly of the pre-replicative complex";"Orc1 removal from chromatin";"G1/S-Specific Transcription";"Assembly of the ORC complex at the origin of replication";"CDT1 association with the CDC6:ORC:origin complex";"Activation of ATR in response to replication stress";"CDC6 association with the ORC:origin complex";"Activation of the pre-replicative complex";"E2F-enabled inhibition of pre-replication complex formation"
Medex_00070000-RA	8	KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05163+2.7.11.1;Reactome: R-HSA-428540;KEGG: 04926+2.7.11.1	"Human papillomavirus infection";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"Thermogenesis";"PI3K-Akt signaling pathway";"Human cytomegalovirus infection";"Activation of RAC1";"Relaxin signaling pathway"
Medex_00091953-RA	7	Reactome: R-HSA-389960;Reactome: R-HSA-390450;Reactome: R-HSA-5620922;Reactome: R-HSA-389957;Reactome: R-HSA-6814122;Reactome: R-HSA-6798695;Reactome: R-HSA-390471	"Formation of tubulin folding intermediates by CCT/TriC";"Folding of actin by CCT/TriC";"BBSome-mediated cargo-targeting to cilium";"Prefoldin mediated transfer of substrate to CCT/TriC";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"Neutrophil degranulation";"Association of TriC/CCT with target proteins during biosynthesis"
Medex_00101731-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00013025-RA	1	KEGG: 00480+3.4.11.2	"Glutathione metabolism"
Medex_00054740-RA	8	Reactome: R-HSA-1222556;Reactome: R-HSA-9639288;Reactome: R-HSA-77387;Reactome: R-HSA-983712;Reactome: R-HSA-917977;KEGG: 00190+7.1.2.2;KEGG: 00195+7.1.2.2;MetaCyc: PWY-7980	"ROS and RNS production in phagocytes";"Amino acids regulate mTORC1";"Insulin receptor recycling";"Ion channel transport";"Transferrin endocytosis and recycling";"Oxidative phosphorylation";"Photosynthesis";"ATP biosynthesis"
Medex_00025658-RA	8	Reactome: R-HSA-380284;Reactome: R-HSA-380259;Reactome: R-HSA-380270;Reactome: R-HSA-5620912;Reactome: R-HSA-6798695;Reactome: R-HSA-2565942;Reactome: R-HSA-8854518;Reactome: R-HSA-380320	"Loss of proteins required for interphase microtubule organization from the centrosome";"Loss of Nlp from mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes";"Anchoring of the basal body to the plasma membrane";"Neutrophil degranulation";"Regulation of PLK1 Activity at G2/M Transition";"AURKA Activation by TPX2";"Recruitment of NuMA to mitotic centrosomes"
Medex_00058744-RA	1	Reactome: R-HSA-5223345	"Miscellaneous transport and binding events"
Medex_00050585-RA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
Medex_00049622-RA	2	Reactome: R-HSA-381340;Reactome: R-HSA-1989781	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression"
Medex_00031297-RA	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
Medex_00096895-RA	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
Medex_00069414-RA	7	KEGG: 00562+3.1.4.11;Reactome: R-HSA-1855204;MetaCyc: PWY-6351;MetaCyc: PWY-7039;MetaCyc: PWY-8052;KEGG: 04070+3.1.4.11;MetaCyc: PWY-6367	"Inositol phosphate metabolism";"Synthesis of IP3 and IP4 in the cytosol";"D-myo-inositol (1,4,5)-trisphosphate biosynthesis";"Phosphatidate metabolism, as a signaling molecule";"2-arachidonoylglycerol biosynthesis";"Phosphatidylinositol signaling system";"D-myo-inositol-5-phosphate metabolism"
Medex_00033146-RA	52	Reactome: R-HSA-5610783;Reactome: R-HSA-8854050;Reactome: R-HSA-1236974;Reactome: R-HSA-2871837;Reactome: R-HSA-8951664;Reactome: R-HSA-174154;Reactome: R-HSA-1169091;Reactome: R-HSA-174184;Reactome: R-HSA-5607764;Reactome: R-HSA-5676590;Reactome: R-HSA-69017;Reactome: R-HSA-69601;Reactome: R-HSA-5362768;Reactome: R-HSA-1234176;Reactome: R-HSA-8948751;Reactome: R-HSA-68827;Reactome: R-HSA-350562;Reactome: R-HSA-5678895;Reactome: R-HSA-69481;Reactome: R-HSA-4641257;Reactome: R-HSA-174113;Reactome: R-HSA-8939236;Reactome: R-HSA-68949;Reactome: R-HSA-382556;Reactome: R-HSA-211733;Reactome: R-HSA-9010553;Reactome: R-HSA-2467813;Reactome: R-HSA-4641258;Reactome: R-HSA-450408;Reactome: R-HSA-180585;Reactome: R-HSA-9020702;Reactome: R-HSA-5358346;Reactome: R-HSA-5658442;Reactome: R-HSA-202424;Reactome: R-HSA-983168;Reactome: R-HSA-5610780;Reactome: R-HSA-8852276;Reactome: R-HSA-5607761;Reactome: R-HSA-174178;Reactome: R-HSA-5632684;Reactome: R-HSA-180534;Reactome: R-HSA-1236978;Reactome: R-HSA-349425;Reactome: R-HSA-5689880;Reactome: R-HSA-5610785;Reactome: R-HSA-4608870;Reactome: R-HSA-5689603;Reactome: R-HSA-5687128;Reactome: R-HSA-5668541;Reactome: R-HSA-75815;Reactome: R-HSA-8939902;Reactome: R-HSA-195253	"Degradation of GLI2 by the proteasome";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"ER-Phagosome pathway";"FCERI mediated NF-kB activation";"Neddylation";"APC/C:Cdc20 mediated degradation of Securin";"Activation of NF-kappaB in B cells";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"CLEC7A (Dectin-1) signaling";"NIK-->noncanonical NF-kB signaling";"CDK-mediated phosphorylation and removal of Cdc6";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of PTEN stability and activity";"CDT1 association with the CDC6:ORC:origin complex";"Regulation of ornithine decarboxylase (ODC)";"Defective CFTR causes cystic fibrosis";"G2/M Checkpoints";"Degradation of AXIN";"SCF-beta-TrCP mediated degradation of Emi1";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Orc1 removal from chromatin";"ABC-family proteins mediated transport";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Regulation of expression of SLITs and ROBOs";"Separation of Sister Chromatids";"Degradation of DVL";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Vif-mediated degradation of APOBEC3G";"Interleukin-1 signaling";"Hedgehog ligand biogenesis";"Regulation of RAS by GAPs";"Downstream TCR signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Degradation of GLI1 by the proteasome";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Dectin-1 mediated noncanonical NF-kB signaling";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Hedgehog 'on' state";"Vpu mediated degradation of CD4";"Cross-presentation of soluble exogenous antigens (endosomes)";"Autodegradation of the E3 ubiquitin ligase COP1";"Ub-specific processing proteases";"GLI3 is processed to GLI3R by the proteasome";"Asymmetric localization of PCP proteins";"UCH proteinases";"MAPK6/MAPK4 signaling";"TNFR2 non-canonical NF-kB pathway";"Ubiquitin-dependent degradation of Cyclin D";"Regulation of RUNX2 expression and activity";"Degradation of beta-catenin by the destruction complex"
Medex_00090017-RA	5	Reactome: R-HSA-5545619;Reactome: R-HSA-4641257;Reactome: R-HSA-5689880;Reactome: R-HSA-8948751;Reactome: R-HSA-201681	"XAV939 inhibits tankyrase, stabilizing AXIN";"Degradation of AXIN";"Ub-specific processing proteases";"Regulation of PTEN stability and activity";"TCF dependent signaling in response to WNT"
Medex_00021341-RA	6	KEGG: 00531+3.2.1.23;KEGG: 00052+3.2.1.23;MetaCyc: PWY-6807;KEGG: 00511+3.2.1.23;KEGG: 00600+3.2.1.23;KEGG: 00604+3.2.1.23	"Glycosaminoglycan degradation";"Galactose metabolism";"Xyloglucan degradation II (exoglucanase)";"Other glycan degradation";"Sphingolipid metabolism";"Glycosphingolipid biosynthesis - ganglio series"
Medex_00056579-RA	1	Reactome: R-HSA-389661	"Glyoxylate metabolism and glycine degradation"
Medex_00030909-RA	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
Medex_00019024-RA	16	Reactome: R-HSA-179409;Reactome: R-HSA-2467813;Reactome: R-HSA-176409;Reactome: R-HSA-174084;Reactome: R-HSA-2559582;Reactome: R-HSA-174048;Reactome: R-HSA-176408;Reactome: R-HSA-983168;Reactome: R-HSA-141430;Reactome: R-HSA-176412;Reactome: R-HSA-174178;Reactome: R-HSA-174184;Reactome: R-HSA-174154;Reactome: R-HSA-8853884;Reactome: R-HSA-69017;Reactome: R-HSA-176407	"APC-Cdc20 mediated degradation of Nek2A";"Separation of Sister Chromatids";"APC/C:Cdc20 mediated degradation of mitotic proteins";"Autodegradation of Cdh1 by Cdh1:APC/C";"Senescence-Associated Secretory Phenotype (SASP)";"APC/C:Cdc20 mediated degradation of Cyclin B";"Regulation of APC/C activators between G1/S and early anaphase";"Antigen processing: Ubiquitination & Proteasome degradation";"Inactivation of APC/C via direct inhibition of the APC/C complex";"Phosphorylation of the APC/C";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"APC/C:Cdc20 mediated degradation of Securin";"Transcriptional Regulation by VENTX";"CDK-mediated phosphorylation and removal of Cdc6";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase"
Medex_00046672-RA	9	Reactome: R-HSA-5674135;Reactome: R-HSA-6802948;Reactome: R-HSA-445355;Reactome: R-HSA-6798695;Reactome: R-HSA-6802952;Reactome: R-HSA-6802955;Reactome: R-HSA-114608;Reactome: R-HSA-9649948;Reactome: R-HSA-6802946	"MAP2K and MAPK activation";"Signaling by high-kinase activity BRAF mutants";"Smooth Muscle Contraction";"Neutrophil degranulation";"Signaling by BRAF and RAF fusions";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"Platelet degranulation";"Signaling downstream of RAS mutants";"Signaling by moderate kinase activity BRAF mutants"
Medex_00022974-RA	2	Reactome: R-HSA-6804758;Reactome: R-HSA-3214847	"Regulation of TP53 Activity through Acetylation";"HATs acetylate histones"
Medex_00033178-RA	2	Reactome: R-HSA-5357905;Reactome: R-HSA-5357956	"Regulation of TNFR1 signaling";"TNFR1-induced NFkappaB signaling pathway"
Medex_00084694-RA	1	MetaCyc: PWY-7942	"5-oxo-L-proline metabolism"
Medex_00077542-RA	1	Reactome: R-HSA-8949613	"Cristae formation"
Medex_00044667-RA	2	Reactome: R-HSA-983231;Reactome: R-HSA-5205685	"Factors involved in megakaryocyte development and platelet production";"Pink/Parkin Mediated Mitophagy"
Medex_00000280-RA	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00048729-RA	10	MetaCyc: PWY-6842;MetaCyc: PWY-5826;KEGG: 00460+2.3.2.2;MetaCyc: PWY-4041;KEGG: 00430+2.3.2.2;KEGG: 00480+2.3.2.2+3.4.19.13;MetaCyc: PWY-7112;MetaCyc: PWY-7559;MetaCyc: PWY-8001;MetaCyc: PWY-4061	"Glutathione-mediated detoxification II";"Hypoglycin biosynthesis";"Cyanoamino acid metabolism";"Gamma-glutamyl cycle";"Taurine and hypotaurine metabolism";"Glutathione metabolism";"4-hydroxy-2-nonenal detoxification";"Glutathione degradation (DUG pathway";"Felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis";"Glutathione-mediated detoxification I"
Medex_00065852-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Medex_00000379-RA	2	Reactome: R-HSA-8876198;Reactome: R-HSA-204005	"RAB GEFs exchange GTP for GDP on RABs";"COPII-mediated vesicle transport"
Medex_00086845-RA	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276	"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination"
Medex_00024151-RA	3	Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-212436	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"Generic Transcription Pathway"
Medex_00073492-RA	2	Reactome: R-HSA-8939243;Reactome: R-HSA-3214858	"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RMTs methylate histone arginines"
Medex_00057619-RA	1	Reactome: R-HSA-5620912	"Anchoring of the basal body to the plasma membrane"
Medex_00047902-RA	6	KEGG: 00561+2.7.1.107;KEGG: 04070+2.7.1.107;MetaCyc: PWY-7817;KEGG: 00564+2.7.1.107;MetaCyc: PWY-7039;Reactome: R-HSA-114508	"Glycerolipid metabolism";"Phosphatidylinositol signaling system";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Glycerophospholipid metabolism";"Phosphatidate metabolism, as a signaling molecule";"Effects of PIP2 hydrolysis"
Medex_00034669-RA	2	Reactome: R-HSA-69273;Reactome: R-HSA-8862803	"Cyclin A/B1/B2 associated events during G2/M transition";"Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models"
Medex_00081528-RA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
Medex_00058398-RA	9	KEGG: 00603+3.2.1.52;MetaCyc: PWY-7883;MetaCyc: PWY-6902;KEGG: 00520+3.2.1.52;KEGG: 00531+3.2.1.52;KEGG: 00513+3.2.1.52;MetaCyc: PWY-7822;KEGG: 00511+3.2.1.52;KEGG: 00604+3.2.1.52	"Glycosphingolipid biosynthesis - globo and isoglobo series";"Anhydromuropeptides recycling II";"Chitin degradation II (Vibrio)";"Amino sugar and nucleotide sugar metabolism";"Glycosaminoglycan degradation";"Various types of N-glycan biosynthesis";"Chitin degradation III (Serratia)";"Other glycan degradation";"Glycosphingolipid biosynthesis - ganglio series"
Medex_00003364-RA	6	KEGG: 00930+3.1.1.17;MetaCyc: PWY-7165;KEGG: 00053+3.1.1.17;KEGG: 00030+3.1.1.17;MetaCyc: PWY-5530;MetaCyc: PWY-2221	"Caprolactam degradation";"L-ascorbate biosynthesis VI (engineered pathway)";"Ascorbate and aldarate metabolism";"Pentose phosphate pathway";"Sorbitol biosynthesis II";"Entner-Doudoroff pathway III (semi-phosphorylative)"
Medex_00062372-RA	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276	"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination"
Medex_00048563-RA	2	KEGG: 00230+2.7.4.8;MetaCyc: PWY-7221	"Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis"
Medex_00089678-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00072671-RA	1	Reactome: R-HSA-425561	"Sodium/Calcium exchangers"
Medex_00008339-RA	2	Reactome: R-HSA-204005;Reactome: R-HSA-5694530	"COPII-mediated vesicle transport";"Cargo concentration in the ER"
Medex_00020618-RA	1	Reactome: R-HSA-112308	"Presynaptic depolarization and calcium channel opening"
Medex_00018261-RA	1	Reactome: R-HSA-6790901	"rRNA modification in the nucleus and cytosol"
Medex_00082342-RA	1	Reactome: R-HSA-9633012	"Response of EIF2AK4 (GCN2) to amino acid deficiency"
Medex_00060562-RA	1	Reactome: R-HSA-2022377	"Metabolism of Angiotensinogen to Angiotensins"
Medex_00035752-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Medex_00033010-RA	6	Reactome: R-HSA-6798695;Reactome: R-HSA-6781827;Reactome: R-HSA-72163;Reactome: R-HSA-6781823;Reactome: R-HSA-6782135;Reactome: R-HSA-6782210	"Neutrophil degranulation";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"mRNA Splicing - Major Pathway";"Formation of TC-NER Pre-Incision Complex";"Dual incision in TC-NER";"Gap-filling DNA repair synthesis and ligation in TC-NER"
Medex_00035592-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Medex_00014231-RA	2	MetaCyc: PWY-7851;KEGG: 00770+2.7.1.24	"Coenzyme A biosynthesis II (eukaryotic)";"Pantothenate and CoA biosynthesis"
Medex_00084287-RA	4	Reactome: R-HSA-2028269;Reactome: R-HSA-8935964;Reactome: R-HSA-191650;Reactome: R-HSA-351906	"Signaling by Hippo";"RUNX1 regulates expression of components of tight junctions";"Regulation of gap junction activity";"Apoptotic cleavage of cell adhesion proteins"
Medex_00006793-RA	1	Reactome: R-HSA-3214858	"RMTs methylate histone arginines"
Medex_00064583-RA	1	Reactome: R-HSA-5658442	"Regulation of RAS by GAPs"
Medex_00039688-RA	1	Reactome: R-HSA-83936	"Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"
Medex_00003884-RA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Medex_00077617-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00095193-RA	1	KEGG: 00480+3.4.11.2	"Glutathione metabolism"
Medex_00033613-RA	8	KEGG: 00010+2.7.1.1;KEGG: 00524+2.7.1.1;KEGG: 00051+2.7.1.1;KEGG: 00520+2.7.1.1;KEGG: 00500+2.7.1.1;KEGG: 00052+2.7.1.1;KEGG: 00521+2.7.1.1;Reactome: R-HSA-70171	"Glycolysis / Gluconeogenesis";"Neomycin, kanamycin and gentamicin biosynthesis";"Fructose and mannose metabolism";"Amino sugar and nucleotide sugar metabolism";"Starch and sucrose metabolism";"Galactose metabolism";"Streptomycin biosynthesis";"Glycolysis"
Medex_00042356-RA	2	Reactome: R-HSA-611105;Reactome: R-HSA-1268020	"Respiratory electron transport";"Mitochondrial protein import"
Medex_00070708-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Medex_00090082-RA	1	Reactome: R-HSA-6811440	"Retrograde transport at the Trans-Golgi-Network"
Medex_00007021-RA	2	Reactome: R-HSA-1433559;Reactome: R-HSA-8951664	"Regulation of KIT signaling";"Neddylation"
Medex_00059678-RA	1	Reactome: R-HSA-2132295	"MHC class II antigen presentation"
Medex_00073791-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Medex_00039260-RA	3	Reactome: R-HSA-196741;Reactome: R-HSA-3359471;KEGG: 00860+2.5.1.17	"Cobalamin (Cbl, vitamin B12) transport and metabolism";"Defective MMAB causes methylmalonic aciduria type cblB";"Porphyrin and chlorophyll metabolism"
Medex_00030520-RA	6	Reactome: R-HSA-3299685;Reactome: R-HSA-9615017;KEGG: 00380+1.11.1.6;Reactome: R-HSA-9033241;KEGG: 00630+1.11.1.6;Reactome: R-HSA-6798695	"Detoxification of Reactive Oxygen Species";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"Tryptophan metabolism";"Peroxisomal protein import";"Glyoxylate and dicarboxylate metabolism";"Neutrophil degranulation"
Medex_00056596-RA	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
Medex_00062966-RA	1	Reactome: R-HSA-211981	"Xenobiotics"
Medex_00042226-RA	5	MetaCyc: PWY-6580;KEGG: 04070+3.1.3.64;KEGG: 00562+3.1.3.64;MetaCyc: PWY-6368;Reactome: R-HSA-1660499	"Phosphatidylinositol biosynthesis I (bacteria)";"Phosphatidylinositol signaling system";"Inositol phosphate metabolism";"3-phosphoinositide degradation";"Synthesis of PIPs at the plasma membrane"
Medex_00030593-RA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
Medex_00039197-RA	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
Medex_00014499-RA	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
Medex_00087714-RA	2	Reactome: R-HSA-5578775;Reactome: R-HSA-2672351	"Ion homeostasis";"Stimuli-sensing channels"
Medex_00059079-RA	2	KEGG: 00500+3.2.1.4;MetaCyc: PWY-6788	"Starch and sucrose metabolism";"Cellulose degradation II (fungi)"
Medex_00008665-RA	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
Medex_00031058-RA	12	Reactome: R-HSA-167290;Reactome: R-HSA-674695;Reactome: R-HSA-167152;Reactome: R-HSA-167243;Reactome: R-HSA-167287;Reactome: R-HSA-75955;Reactome: R-HSA-167238;Reactome: R-HSA-6796648;Reactome: R-HSA-112382;Reactome: R-HSA-167246;Reactome: R-HSA-6804756;Reactome: R-HSA-167200	"Pausing and recovery of HIV elongation";"RNA Polymerase II Pre-transcription Events";"Formation of HIV elongation complex in the absence of HIV Tat";"Tat-mediated HIV elongation arrest and recovery";"HIV elongation arrest and recovery";"RNA Polymerase II Transcription Elongation";"Pausing and recovery of Tat-mediated HIV elongation";"TP53 Regulates Transcription of DNA Repair Genes";"Formation of RNA Pol II elongation complex";"Tat-mediated elongation of the HIV-1 transcript";"Regulation of TP53 Activity through Phosphorylation";"Formation of HIV-1 elongation complex containing HIV-1 Tat"
Medex_00074465-RA	4	KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16;Reactome: R-HSA-180024;KEGG: 04660+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation";"DARPP-32 events";"T cell receptor signaling pathway"
Medex_00038266-RA	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
Medex_00030810-RA	16	Reactome: R-HSA-2408557;Reactome: R-HSA-72689;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-156902;Reactome: R-HSA-72695;Reactome: R-HSA-72649;Reactome: R-HSA-192823;Reactome: R-HSA-6791226;Reactome: R-HSA-72702;Reactome: R-HSA-72764;Reactome: R-HSA-975956;Reactome: R-HSA-72706;Reactome: R-HSA-9633012;Reactome: R-HSA-1799339;Reactome: R-HSA-975957	"Selenocysteine synthesis";"Formation of a pool of free 40S subunits";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Peptide chain elongation";"Formation of the ternary complex, and subsequently, the 43S complex";"Translation initiation complex formation";"Viral mRNA Translation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Ribosomal scanning and start codon recognition";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
Medex_00050837-RA	6	MetaCyc: PWY-5884;Reactome: R-HSA-9640463;KEGG: 00073+1.2.1.84;MetaCyc: PWY-7782;MetaCyc: PWY-7656;MetaCyc: PWY-6733	"Wax esters biosynthesis I";"Wax biosynthesis";"Cutin, suberine and wax biosynthesis";"Plasmalogen biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Sporopollenin precursors biosynthesis"
Medex_00063616-RA	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
Medex_00028632-RA	4	MetaCyc: PWY-2781;Reactome: R-HSA-6787450;KEGG: 00908+2.5.1.75;Reactome: R-HSA-6782315	"Cis-zeatin biosynthesis";"tRNA modification in the mitochondrion";"Zeatin biosynthesis";"tRNA modification in the nucleus and cytosol"
Medex_00056396-RA	1	Reactome: R-HSA-1655829	"Regulation of cholesterol biosynthesis by SREBP (SREBF)"
Medex_00024779-RA	22	MetaCyc: PWY-7238;MetaCyc: PWY-5384;MetaCyc: PWY-7347;KEGG: 00520+5.3.1.9;MetaCyc: PWY-6981;MetaCyc: PWY-7385;KEGG: 00030+5.3.1.9;MetaCyc: PWY-5054;MetaCyc: PWY-5659;Reactome: R-HSA-70171;Reactome: R-HSA-70263;Reactome: R-HSA-6798695;MetaCyc: PWY-5514;Reactome: R-HSA-5628897;MetaCyc: PWY-8013;MetaCyc: PWY-621;MetaCyc: PWY-6992;KEGG: 00500+5.3.1.9;MetaCyc: PWY-622;MetaCyc: PWY-6142;KEGG: 00010+5.3.1.9;MetaCyc: PWY-3801	"Sucrose biosynthesis II";"Sucrose degradation IV (sucrose phosphorylase)";"Sucrose biosynthesis III";"Amino sugar and nucleotide sugar metabolism";"Chitin biosynthesis";"1,3-propanediol biosynthesis (engineered)";"Pentose phosphate pathway";"D-sorbitol biosynthesis I";"GDP-mannose biosynthesis";"Glycolysis";"Gluconeogenesis";"Neutrophil degranulation";"UDP-N-acetyl-D-galactosamine biosynthesis II";"TP53 Regulates Metabolic Genes";"UDP-N-acetyl-D-galactosamine biosynthesis III";"Sucrose degradation III (sucrose invertase)";"1,5-anhydrofructose degradation";"Starch and sucrose metabolism";"Starch biosynthesis";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Glycolysis / Gluconeogenesis";"Sucrose degradation II (sucrose synthase)"
Medex_00101260-RA	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
Medex_00013806-RA	11	Reactome: R-HSA-163359;Reactome: R-HSA-164378;Reactome: R-HSA-418555;Reactome: R-HSA-170670;Reactome: R-HSA-163615;Reactome: R-HSA-418597;Reactome: R-HSA-5610787;Reactome: R-HSA-418594;Reactome: R-HSA-432040;KEGG: 00230+4.6.1.1;Reactome: R-HSA-170660	"Glucagon signaling in metabolic regulation";"PKA activation in glucagon signalling";"G alpha (s) signalling events";"Adenylate cyclase inhibitory pathway";"PKA activation";"G alpha (z) signalling events";"Hedgehog 'off' state";"G alpha (i) signalling events";"Vasopressin regulates renal water homeostasis via Aquaporins";"Purine metabolism";"Adenylate cyclase activating pathway"
Medex_00073498-RA	2	Reactome: R-HSA-3238698;Reactome: R-HSA-373080	"WNT ligand biogenesis and trafficking";"Class B/2 (Secretin family receptors)"
Medex_00090190-RA	1	Reactome: R-HSA-6803157	"Antimicrobial peptides"
Medex_00073011-RA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
Medex_00035733-RA	1	Reactome: R-HSA-9033241	"Peroxisomal protein import"
Medex_00057426-RA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
Medex_00070451-RA	16	Reactome: R-HSA-8853884;Reactome: R-HSA-174154;Reactome: R-HSA-174184;Reactome: R-HSA-174178;Reactome: R-HSA-176412;Reactome: R-HSA-176407;Reactome: R-HSA-69017;Reactome: R-HSA-176409;Reactome: R-HSA-2467813;Reactome: R-HSA-179409;Reactome: R-HSA-141430;Reactome: R-HSA-983168;Reactome: R-HSA-176408;Reactome: R-HSA-174048;Reactome: R-HSA-2559582;Reactome: R-HSA-174084	"Transcriptional Regulation by VENTX";"APC/C:Cdc20 mediated degradation of Securin";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Phosphorylation of the APC/C";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"CDK-mediated phosphorylation and removal of Cdc6";"APC/C:Cdc20 mediated degradation of mitotic proteins";"Separation of Sister Chromatids";"APC-Cdc20 mediated degradation of Nek2A";"Inactivation of APC/C via direct inhibition of the APC/C complex";"Antigen processing: Ubiquitination & Proteasome degradation";"Regulation of APC/C activators between G1/S and early anaphase";"APC/C:Cdc20 mediated degradation of Cyclin B";"Senescence-Associated Secretory Phenotype (SASP)";"Autodegradation of Cdh1 by Cdh1:APC/C"
Medex_00032709-RA	33	Reactome: R-HSA-5654688;Reactome: R-HSA-9664565;Reactome: R-HSA-1250347;Reactome: R-HSA-9027284;Reactome: R-HSA-5654719;Reactome: R-HSA-512988;Reactome: R-HSA-8853659;Reactome: R-HSA-1236382;Reactome: R-HSA-5654704;Reactome: R-HSA-9034864;Reactome: R-HSA-2428933;Reactome: R-HSA-1250196;Reactome: R-HSA-381038;Reactome: R-HSA-9634285;Reactome: R-HSA-210993;Reactome: R-HSA-354192;Reactome: R-HSA-2424491;Reactome: R-HSA-8983432;Reactome: R-HSA-912526;Reactome: R-HSA-2871796;Reactome: R-HSA-180336;Reactome: R-HSA-8851805;Reactome: R-HSA-74749;Reactome: R-HSA-9020558;Reactome: R-HSA-5673001;Reactome: R-HSA-167044;Reactome: R-HSA-9026519;Reactome: R-HSA-2730905;Reactome: R-HSA-9009391;Reactome: R-HSA-5637810;Reactome: R-HSA-2871809;Reactome: R-HSA-5654699;Reactome: R-HSA-74751	"SHC-mediated cascade:FGFR1";"Signaling by ERBB2 KD Mutants";"SHC1 events in ERBB4 signaling";"Erythropoietin activates RAS";"SHC-mediated cascade:FGFR4";"Interleukin-3, Interleukin-5 and GM-CSF signaling";"RET signaling";"Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants";"SHC-mediated cascade:FGFR3";"Activated NTRK3 signals through RAS";"SHC-related events triggered by IGF1R";"SHC1 events in ERBB2 signaling";"XBP1(S) activates chaperone genes";"Constitutive Signaling by Overexpressed ERBB2";"Tie2 Signaling";"Integrin signaling";"DAP12 signaling";"Interleukin-15 signaling";"Interleukin receptor SHC signaling";"FCERI mediated MAPK activation";"SHC1 events in EGFR signaling";"MET activates RAS signaling";"Signal attenuation";"Interleukin-2 signaling";"RAF/MAP kinase cascade";"Signalling to RAS";"Activated NTRK2 signals through RAS";"Role of LAT2/NTAL/LAB on calcium mobilization";"Extra-nuclear estrogen signaling";"Constitutive Signaling by EGFRvIII";"FCERI mediated Ca+2 mobilization";"SHC-mediated cascade:FGFR2";"Insulin receptor signalling cascade"
Medex_00001733-RA	2	Reactome: R-HSA-3299685;MetaCyc: PWY-6854	"Detoxification of Reactive Oxygen Species";"Ethylene biosynthesis III (microbes)"
Medex_00102479-RA	10	Reactome: R-HSA-5693616;Reactome: R-HSA-5693554;Reactome: R-HSA-5685942;Reactome: R-HSA-5685938;Reactome: R-HSA-5693607;Reactome: R-HSA-5693568;Reactome: R-HSA-6804756;Reactome: R-HSA-5693579;Reactome: R-HSA-69473;Reactome: R-HSA-3108214	"Presynaptic phase of homologous DNA pairing and strand exchange";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"HDR through Homologous Recombination (HRR)";"HDR through Single Strand Annealing (SSA)";"Processing of DNA double-strand break ends";"Resolution of D-loop Structures through Holliday Junction Intermediates";"Regulation of TP53 Activity through Phosphorylation";"Homologous DNA Pairing and Strand Exchange";"G2/M DNA damage checkpoint";"SUMOylation of DNA damage response and repair proteins"
Medex_00009606-RA	1	Reactome: R-HSA-6811440	"Retrograde transport at the Trans-Golgi-Network"
Medex_00071704-RA	1	Reactome: R-HSA-211981	"Xenobiotics"
Medex_00078596-RA	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
Medex_00019637-RA	6	MetaCyc: PWY-5789;Reactome: R-HSA-196780;MetaCyc: PWY-5744;MetaCyc: PWY-6722;MetaCyc: PWY-5743;MetaCyc: PWY-4381	"3-hydroxypropanoate/4-hydroxybutanate cycle";"Biotin transport and metabolism";"Glyoxylate assimilation";"Candicidin biosynthesis";"3-hydroxypropanoate cycle";"Fatty acid biosynthesis initiation (bacteria and plants)"
Medex_00077883-RA	13	Reactome: R-HSA-6791226;Reactome: R-HSA-2408557;Reactome: R-HSA-72764;Reactome: R-HSA-72689;Reactome: R-HSA-975956;Reactome: R-HSA-72706;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-156902;Reactome: R-HSA-9633012;Reactome: R-HSA-1799339;Reactome: R-HSA-192823;Reactome: R-HSA-975957	"Major pathway of rRNA processing in the nucleolus and cytosol";"Selenocysteine synthesis";"Eukaryotic Translation Termination";"Formation of a pool of free 40S subunits";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Peptide chain elongation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"SRP-dependent cotranslational protein targeting to membrane";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
Medex_00077710-RA	1	Reactome: R-HSA-8874211	"CREB3 factors activate genes"
Medex_00067381-RA	2	Reactome: R-HSA-418890;Reactome: R-HSA-3295583	"Role of second messengers in netrin-1 signaling";"TRP channels"
Medex_00073426-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Medex_00006004-RA	1	Reactome: R-HSA-5656169	"Termination of translesion DNA synthesis"
Medex_00049524-RA	10	MetaCyc: PWY-6842;KEGG: 00480+2.3.2.2+3.4.19.13;KEGG: 00430+2.3.2.2;MetaCyc: PWY-4041;KEGG: 00460+2.3.2.2;MetaCyc: PWY-5826;MetaCyc: PWY-4061;MetaCyc: PWY-8001;MetaCyc: PWY-7559;MetaCyc: PWY-7112	"Glutathione-mediated detoxification II";"Glutathione metabolism";"Taurine and hypotaurine metabolism";"Gamma-glutamyl cycle";"Cyanoamino acid metabolism";"Hypoglycin biosynthesis";"Glutathione-mediated detoxification I";"Felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis";"Glutathione degradation (DUG pathway";"4-hydroxy-2-nonenal detoxification"
Medex_00041483-RA	5	Reactome: R-HSA-1266695;Reactome: R-HSA-3247509;Reactome: R-HSA-8939243;Reactome: R-HSA-3214858;Reactome: R-HSA-201722	"Interleukin-7 signaling";"Chromatin modifying enzymes";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RMTs methylate histone arginines";"Formation of the beta-catenin:TCF transactivating complex"
Medex_00045086-RA	14	MetaCyc: PWY-7036;MetaCyc: PWY-7619;MetaCyc: PWY-7602;MetaCyc: PWY-6433;Reactome: R-HSA-75876;MetaCyc: PWY-7035;MetaCyc: PWY-5972;MetaCyc: PWY-7601;MetaCyc: PWY-7724;MetaCyc: PWY-8041;MetaCyc: PWY-5080;MetaCyc: PWY-6598;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7725	"Very long chain fatty acid biosynthesis II";"Juniperonate biosynthesis";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Hydroxylated fatty acid biosynthesis (plants)";"Synthesis of very long-chain fatty acyl-CoAs";"(9Z)-tricosene biosynthesis";"Stearate biosynthesis I (animals)";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Ultra-long-chain fatty acid biosynthesis";"Very long chain fatty acid biosynthesis I";"Sciadonate biosynthesis";"Fatty acid elongation";"Arachidonate biosynthesis V (8-detaturase, mammals)"
Medex_00013228-RA	13	Reactome: R-HSA-156590;MetaCyc: PWY-6370;MetaCyc: PWY-4061;MetaCyc: PWY-7112;KEGG: 00480+2.5.1.18+1.8.5.1;Reactome: R-HSA-196836;KEGG: 00980+2.5.1.18;MetaCyc: PWY-2261;KEGG: 00982+2.5.1.18;MetaCyc: PWY-7533;KEGG: 00983+2.5.1.18;MetaCyc: PWY-6842;KEGG: 00053+1.8.5.1	"Glutathione conjugation";"Ascorbate recycling (cytosolic)";"Glutathione-mediated detoxification I";"4-hydroxy-2-nonenal detoxification";"Glutathione metabolism";"Vitamin C (ascorbate) metabolism";"Metabolism of xenobiotics by cytochrome P450";"Ascorbate glutathione cycle";"Drug metabolism - cytochrome P450";"Gliotoxin biosynthesis";"Drug metabolism - other enzymes";"Glutathione-mediated detoxification II";"Ascorbate and aldarate metabolism"
Medex_00060461-RA	7	KEGG: 00500+2.4.1.25;MetaCyc: PWY-5941;MetaCyc: PWY-6737;Reactome: R-HSA-6798695;MetaCyc: PWY-7238;Reactome: R-HSA-70221;MetaCyc: PWY-6724	"Starch and sucrose metabolism";"Glycogen degradation II";"Starch degradation V";"Neutrophil degranulation";"Sucrose biosynthesis II";"Glycogen breakdown (glycogenolysis)";"Starch degradation II"
Medex_00028885-RA	4	Reactome: R-HSA-674695;Reactome: R-HSA-112382;Reactome: R-HSA-75955;Reactome: R-HSA-8866654	"RNA Polymerase II Pre-transcription Events";"Formation of RNA Pol II elongation complex";"RNA Polymerase II Transcription Elongation";"E3 ubiquitin ligases ubiquitinate target proteins"
Medex_00022229-RA	1	Reactome: R-HSA-1660661	"Sphingolipid de novo biosynthesis"
Medex_00064114-RA	5	Reactome: R-HSA-6804757;Reactome: R-HSA-5218920;Reactome: R-HSA-5674400;Reactome: R-HSA-389357;Reactome: R-HSA-1257604	"Regulation of TP53 Degradation";"VEGFR2 mediated vascular permeability";"Constitutive Signaling by AKT1 E17K in Cancer";"CD28 dependent PI3K/Akt signaling";"PIP3 activates AKT signaling"
Medex_00054239-RA	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
Medex_00093767-RA	6	MetaCyc: PWY-7442;MetaCyc: PWY-6608;KEGG: 00230+3.5.4.3;Reactome: R-HSA-74259;MetaCyc: PWY-5497;MetaCyc: PWY-6606	"Drosopterin and aurodrosopterin biosynthesis";"Guanosine nucleotides degradation III";"Purine metabolism";"Purine catabolism";"Purine nucleobases degradation II (anaerobic)";"Guanosine nucleotides degradation II"
Medex_00037480-RA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Medex_00064775-RA	1	Reactome: R-HSA-8951664	"Neddylation"
Medex_00059437-RA	1	Reactome: R-HSA-5635838	"Activation of SMO"
Medex_00000260-RA	31	MetaCyc: PWY-7723;MetaCyc: PWY-7663;MetaCyc: PWY-6282;MetaCyc: PWY-5966-1;MetaCyc: PWYG-321;MetaCyc: PWY-5142;MetaCyc: PWY-5366;MetaCyc: PWY-7858;MetaCyc: PWY-7664;MetaCyc: PWY-5973;Reactome: R-HSA-163765;MetaCyc: PWY-5994;MetaCyc: PWY-8012;KEGG: 00061+1.1.1.100+2.3.1.85+4.2.1.59+2.3.1.39+2.3.1.41+3.1.2.14;MetaCyc: PWY-6519;MetaCyc: PWY-4381;Reactome: R-HSA-2426168;MetaCyc: PWY-6113;MetaCyc: PWY-7388;Reactome: R-HSA-9029558;MetaCyc: PWY-5971;Reactome: R-HSA-75105;MetaCyc: PWY-5147;KEGG: 00780+1.1.1.100+4.2.1.59+2.3.1.41;MetaCyc: PWY-5367;MetaCyc: PWY-6799;MetaCyc: PWY-8049;MetaCyc: PWY-7746;MetaCyc: PWY-8047;Reactome: R-HSA-199220;MetaCyc: PWY-5989	"Bacterial bioluminescence";"Gondoate biosynthesis (anaerobic)";"Palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate)";"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)";"";"Acyl-[acyl-carrier protein] thioesterase pathway";"Palmitoleate biosynthesis II (plants and bacteria)";"(5Z)-dodecenoate biosynthesis II";"Oleate biosynthesis IV (anaerobic)";"Cis-vaccenate biosynthesis";"ChREBP activates metabolic gene expression";"Palmitate biosynthesis (animals and fungi, cytoplasm)";"Mupirocin biosynthesis";"Fatty acid biosynthesis";"8-amino-7-oxononanoate biosynthesis I";"Fatty acid biosynthesis initiation (bacteria and plants)";"Activation of gene expression by SREBF (SREBP)";"Superpathway of mycolate biosynthesis";"Octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast)";"NR1H2 & NR1H3 regulate gene expression linked to lipogenesis";"Palmitate biosynthesis II (bacteria and plant cytoplasm)";"Fatty acyl-CoA biosynthesis";"Oleate biosynthesis I (plants)";"Biotin metabolism";"Petroselinate biosynthesis";"Fatty acid biosynthesis initiation (plant mitochondria)";"Pederin biosynthesis";"Mycobacterial sulfolipid biosynthesis";"Bryostatin biosynthesis";"Vitamin B5 (pantothenate) metabolism";"Stearate biosynthesis II (bacteria and plants)"
Medex_00045204-RA	2	KEGG: 00627+3.6.1.7;KEGG: 00620+3.6.1.7	"Aminobenzoate degradation";"Pyruvate metabolism"
Medex_00077007-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Medex_00030402-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Medex_00084981-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00016361-RA	3	Reactome: R-HSA-72165;Reactome: R-HSA-430039;Reactome: R-HSA-72163	"mRNA Splicing - Minor Pathway";"mRNA decay by 5' to 3' exoribonuclease";"mRNA Splicing - Major Pathway"
Medex_00103442-RA	6	Reactome: R-HSA-196819;KEGG: 00730+2.7.6.2;MetaCyc: PWY-6898;MetaCyc: PWY-7356;MetaCyc: PWY-6908;MetaCyc: PWY-6907	"Vitamin B1 (thiamin) metabolism";"Thiamine metabolism";"Thiamine salvage III";"Thiamine salvage IV (yeast)";"Thiamine diphosphate biosynthesis IV (eukaryotes)";"Thiamine diphosphate biosynthesis III (Staphylococcus)"
Medex_00034671-RA	2	Reactome: R-HSA-8862803;Reactome: R-HSA-69273	"Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models";"Cyclin A/B1/B2 associated events during G2/M transition"
Medex_00091346-RA	1	Reactome: R-HSA-1483255	"PI Metabolism"
Medex_00075861-RA	4	Reactome: R-HSA-2470946;Reactome: R-HSA-2467813;Reactome: R-HSA-2468052;Reactome: R-HSA-2500257	"Cohesin Loading onto Chromatin";"Separation of Sister Chromatids";"Establishment of Sister Chromatid Cohesion";"Resolution of Sister Chromatid Cohesion"
Medex_00071191-RA	1	KEGG: 00480+3.4.11.2	"Glutathione metabolism"
Medex_00013134-RA	2	Reactome: R-HSA-8876198;Reactome: R-HSA-204005	"RAB GEFs exchange GTP for GDP on RABs";"COPII-mediated vesicle transport"
Medex_00048993-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Medex_00053940-RA	3	Reactome: R-HSA-2024101;Reactome: R-HSA-2206296;Reactome: R-HSA-2024096	"CS/DS degradation";"MPS II - Hunter syndrome";"HS-GAG degradation"
Medex_00030740-RA	14	Reactome: R-HSA-167287;Reactome: R-HSA-113418;Reactome: R-HSA-167243;Reactome: R-HSA-674695;Reactome: R-HSA-167152;Reactome: R-HSA-167242;Reactome: R-HSA-167290;Reactome: R-HSA-167158;Reactome: R-HSA-167200;Reactome: R-HSA-167246;Reactome: R-HSA-112382;Reactome: R-HSA-75955;Reactome: R-HSA-6796648;Reactome: R-HSA-167238	"HIV elongation arrest and recovery";"Formation of the Early Elongation Complex";"Tat-mediated HIV elongation arrest and recovery";"RNA Polymerase II Pre-transcription Events";"Formation of HIV elongation complex in the absence of HIV Tat";"Abortive elongation of HIV-1 transcript in the absence of Tat";"Pausing and recovery of HIV elongation";"Formation of the HIV-1 Early Elongation Complex";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Tat-mediated elongation of the HIV-1 transcript";"Formation of RNA Pol II elongation complex";"RNA Polymerase II Transcription Elongation";"TP53 Regulates Transcription of DNA Repair Genes";"Pausing and recovery of Tat-mediated HIV elongation"
Medex_00051451-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Medex_00070838-RA	1	KEGG: 00760+2.3.1.286	"Nicotinate and nicotinamide metabolism"
Medex_00024781-RA	22	KEGG: 00030+5.3.1.9;MetaCyc: PWY-7347;MetaCyc: PWY-7385;KEGG: 00520+5.3.1.9;MetaCyc: PWY-6981;MetaCyc: PWY-7238;MetaCyc: PWY-5384;Reactome: R-HSA-70171;Reactome: R-HSA-70263;MetaCyc: PWY-5659;MetaCyc: PWY-5054;MetaCyc: PWY-5514;Reactome: R-HSA-5628897;MetaCyc: PWY-8013;Reactome: R-HSA-6798695;MetaCyc: PWY-3801;KEGG: 00010+5.3.1.9;MetaCyc: PWY-622;KEGG: 00500+5.3.1.9;MetaCyc: PWY-6992;MetaCyc: PWY-6142;MetaCyc: PWY-621	"Pentose phosphate pathway";"Sucrose biosynthesis III";"1,3-propanediol biosynthesis (engineered)";"Amino sugar and nucleotide sugar metabolism";"Chitin biosynthesis";"Sucrose biosynthesis II";"Sucrose degradation IV (sucrose phosphorylase)";"Glycolysis";"Gluconeogenesis";"GDP-mannose biosynthesis";"D-sorbitol biosynthesis I";"UDP-N-acetyl-D-galactosamine biosynthesis II";"TP53 Regulates Metabolic Genes";"UDP-N-acetyl-D-galactosamine biosynthesis III";"Neutrophil degranulation";"Sucrose degradation II (sucrose synthase)";"Glycolysis / Gluconeogenesis";"Starch biosynthesis";"Starch and sucrose metabolism";"1,5-anhydrofructose degradation";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Sucrose degradation III (sucrose invertase)"
Medex_00004391-RA	3	Reactome: R-HSA-936837;Reactome: R-HSA-5578775;Reactome: R-HSA-418359	"Ion transport by P-type ATPases";"Ion homeostasis";"Reduction of cytosolic Ca++ levels"
Medex_00076375-RA	10	Reactome: R-HSA-2024096;MetaCyc: PWY-6807;KEGG: 00511+3.2.1.23;KEGG: 00604+3.2.1.23;KEGG: 00531+3.2.1.23;KEGG: 00052+3.2.1.23;Reactome: R-HSA-6798695;Reactome: R-HSA-2160916;KEGG: 00600+3.2.1.23;Reactome: R-HSA-2206292	"HS-GAG degradation";"Xyloglucan degradation II (exoglucanase)";"Other glycan degradation";"Glycosphingolipid biosynthesis - ganglio series";"Glycosaminoglycan degradation";"Galactose metabolism";"Neutrophil degranulation";"Hyaluronan uptake and degradation";"Sphingolipid metabolism";"MPS VII - Sly syndrome"
Medex_00005558-RA	4	KEGG: 00410+4.1.1.9;KEGG: 00640+4.1.1.9;Reactome: R-HSA-390247;Reactome: R-HSA-9033241	"beta-Alanine metabolism";"Propanoate metabolism";"Beta-oxidation of very long chain fatty acids";"Peroxisomal protein import"
Medex_00000386-RA	3	Reactome: R-HSA-382556;Reactome: R-HSA-1989781;Reactome: R-HSA-5678771	"ABC-family proteins mediated transport";"PPARA activates gene expression";"Defective ABCB4 causes progressive familial intrahepatic cholestasis 3, intrahepatic cholestasis of pregnancy 3 and gallbladder disease 1"
Medex_00008969-RA	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
Medex_00063110-RA	24	Reactome: R-HSA-2871796;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;Reactome: R-HSA-211728;Reactome: R-HSA-5687128;Reactome: R-HSA-211736;Reactome: R-HSA-4420097;Reactome: R-HSA-389359;KEGG: 04926+2.7.11.1;Reactome: R-HSA-428540;Reactome: R-HSA-8950505;KEGG: 04150+2.7.11.1;Reactome: R-HSA-211733;KEGG: 04714+2.7.11.1;Reactome: R-HSA-3928664;Reactome: R-HSA-5627123;Reactome: R-HSA-202433;Reactome: R-HSA-445355;KEGG: 04151+2.7.11.1;Reactome: R-HSA-399954;Reactome: R-HSA-5621575;Reactome: R-HSA-5218920;Reactome: R-HSA-164944;KEGG: 05163+2.7.11.1	"FCERI mediated MAPK activation";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Regulation of PAK-2p34 activity by PS-GAP/RHG10";"MAPK6/MAPK4 signaling";"Stimulation of the cell death response by PAK-2p34";"VEGFA-VEGFR2 Pathway";"CD28 dependent Vav1 pathway";"Relaxin signaling pathway";"Activation of RAC1";"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation";"mTOR signaling pathway";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Thermogenesis";"Ephrin signaling";"RHO GTPases activate PAKs";"Generation of second messenger molecules";"Smooth Muscle Contraction";"PI3K-Akt signaling pathway";"Sema3A PAK dependent Axon repulsion";"CD209 (DC-SIGN) signaling";"VEGFR2 mediated vascular permeability";"Nef and signal transduction";"Human cytomegalovirus infection"
Medex_00009121-RA	1	Reactome: R-HSA-6784531	"tRNA processing in the nucleus"
Medex_00076837-RA	5	Reactome: R-HSA-6811436;Reactome: R-HSA-6807878;Reactome: R-HSA-3371497;Reactome: R-HSA-6798695;Reactome: R-HSA-2132295	"COPI-independent Golgi-to-ER retrograde traffic";"COPI-mediated anterograde transport";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Neutrophil degranulation";"MHC class II antigen presentation"
Medex_00001967-RA	6	KEGG: 00073+1.2.1.84;MetaCyc: PWY-7656;MetaCyc: PWY-7782;MetaCyc: PWY-6733;MetaCyc: PWY-5884;Reactome: R-HSA-9640463	"Cutin, suberine and wax biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Plasmalogen biosynthesis";"Sporopollenin precursors biosynthesis";"Wax esters biosynthesis I";"Wax biosynthesis"
Medex_00094223-RA	2	Reactome: R-HSA-8964038;Reactome: R-HSA-6798695	"LDL clearance";"Neutrophil degranulation"
Medex_00052576-RA	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
Medex_00036726-RA	14	Reactome: R-HSA-75876;MetaCyc: PWY-7035;MetaCyc: PWY-5972;MetaCyc: PWY-7602;MetaCyc: PWY-7619;MetaCyc: PWY-7036;MetaCyc: PWY-6433;MetaCyc: PWY-8041;MetaCyc: PWY-5080;MetaCyc: PWY-7725;MetaCyc: PWY-6598;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7724;MetaCyc: PWY-7601	"Synthesis of very long-chain fatty acyl-CoAs";"(9Z)-tricosene biosynthesis";"Stearate biosynthesis I (animals)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Juniperonate biosynthesis";"Very long chain fatty acid biosynthesis II";"Hydroxylated fatty acid biosynthesis (plants)";"Ultra-long-chain fatty acid biosynthesis";"Very long chain fatty acid biosynthesis I";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Sciadonate biosynthesis";"Fatty acid elongation";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)"
Medex_00005898-RA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
Medex_00035936-RA	2	Reactome: R-HSA-390471;Reactome: R-HSA-1660662	"Association of TriC/CCT with target proteins during biosynthesis";"Glycosphingolipid metabolism"
Medex_00034886-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Medex_00003288-RA	7	Reactome: R-HSA-2979096;MetaCyc: PWY-7511;Reactome: R-HSA-2122948;Reactome: R-HSA-2644606;Reactome: R-HSA-9013507;Reactome: R-HSA-2894862;Reactome: R-HSA-2691232	"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Protein ubiquitination";"Activated NOTCH1 Transmits Signal to the Nucleus";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Constitutive Signaling by NOTCH1 HD Domain Mutants"
Medex_00050865-RA	1	Reactome: R-HSA-5689901	"Metalloprotease DUBs"
Medex_00027354-RA	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
Medex_00099127-RA	2	Reactome: R-HSA-162710;KEGG: 00563+3.5.1.89	"Synthesis of glycosylphosphatidylinositol (GPI)";"Glycosylphosphatidylinositol (GPI)-anchor biosynthesis"
Medex_00026941-RA	9	Reactome: R-HSA-6804756;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;Reactome: R-HSA-6782315	"Regulation of TP53 Activity through Phosphorylation";"PI3K-Akt signaling pathway";"Relaxin signaling pathway";"Human cytomegalovirus infection";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"mTOR signaling pathway";"Thermogenesis";"tRNA modification in the nucleus and cytosol"
Medex_00001028-RA	3	MetaCyc: PWY-6558;Reactome: R-HSA-2022928;KEGG: 00534+5.1.3.17	"Heparan sulfate biosynthesis (late stages)";"HS-GAG biosynthesis";"Glycosaminoglycan biosynthesis - heparan sulfate / heparin"
Medex_00040000-RA	1	Reactome: R-HSA-6783984	"Glycine degradation"
Medex_00074368-RA	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
Medex_00067552-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00103515-RA	1	Reactome: R-HSA-5576886	"Phase 4 - resting membrane potential"
Medex_00060310-RA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
Medex_00037611-RA	1	Reactome: R-HSA-196819	"Vitamin B1 (thiamin) metabolism"
Medex_00062309-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Medex_00035620-RA	11	Reactome: R-HSA-5696400;Reactome: R-HSA-68962;Reactome: R-HSA-6782135;Reactome: R-HSA-110314;Reactome: R-HSA-5656169;Reactome: R-HSA-5651801;Reactome: R-HSA-68952;Reactome: R-HSA-174430;Reactome: R-HSA-6782210;Reactome: R-HSA-5685942;Reactome: R-HSA-5696397	"Dual Incision in GG-NER";"Activation of the pre-replicative complex";"Dual incision in TC-NER";"Recognition of DNA damage by PCNA-containing replication complex";"Termination of translesion DNA synthesis";"PCNA-Dependent Long Patch Base Excision Repair";"DNA replication initiation";"Telomere C-strand synthesis initiation";"Gap-filling DNA repair synthesis and ligation in TC-NER";"HDR through Homologous Recombination (HRR)";"Gap-filling DNA repair synthesis and ligation in GG-NER"
Medex_00036110-RA	6	MetaCyc: PWY-6807;KEGG: 00511+3.2.1.23;KEGG: 00600+3.2.1.23;KEGG: 00604+3.2.1.23;KEGG: 00052+3.2.1.23;KEGG: 00531+3.2.1.23	"Xyloglucan degradation II (exoglucanase)";"Other glycan degradation";"Sphingolipid metabolism";"Glycosphingolipid biosynthesis - ganglio series";"Galactose metabolism";"Glycosaminoglycan degradation"
Medex_00090397-RA	3	Reactome: R-HSA-6798695;Reactome: R-HSA-447043;Reactome: R-HSA-3928664	"Neutrophil degranulation";"Neurofascin interactions";"Ephrin signaling"
Medex_00041523-RA	5	Reactome: R-HSA-1660662;Reactome: R-HSA-4085001;Reactome: R-HSA-4341670;Reactome: R-HSA-2132295;Reactome: R-HSA-6798695	"Glycosphingolipid metabolism";"Sialic acid metabolism";"Defective NEU1 causes sialidosis";"MHC class II antigen presentation";"Neutrophil degranulation"
Medex_00036903-RA	2	Reactome: R-HSA-5689603;Reactome: R-HSA-5696394	"UCH proteinases";"DNA Damage Recognition in GG-NER"
Medex_00080528-RA	12	Reactome: R-HSA-167243;Reactome: R-HSA-167287;Reactome: R-HSA-167152;Reactome: R-HSA-674695;Reactome: R-HSA-167290;Reactome: R-HSA-167200;Reactome: R-HSA-167246;Reactome: R-HSA-6804756;Reactome: R-HSA-112382;Reactome: R-HSA-75955;Reactome: R-HSA-167238;Reactome: R-HSA-6796648	"Tat-mediated HIV elongation arrest and recovery";"HIV elongation arrest and recovery";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Polymerase II Pre-transcription Events";"Pausing and recovery of HIV elongation";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Tat-mediated elongation of the HIV-1 transcript";"Regulation of TP53 Activity through Phosphorylation";"Formation of RNA Pol II elongation complex";"RNA Polymerase II Transcription Elongation";"Pausing and recovery of Tat-mediated HIV elongation";"TP53 Regulates Transcription of DNA Repair Genes"
Medex_00000698-RA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00046714-RA	3	MetaCyc: PWY-6348;KEGG: 00730+3.1.3.2;KEGG: 00740+3.1.3.2	"Phosphate acquisition";"Thiamine metabolism";"Riboflavin metabolism"
Medex_00069834-RA	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
Medex_00062962-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00007216-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Medex_00077873-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00005126-RA	2	Reactome: R-HSA-975957;Reactome: R-HSA-9010553	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs"
Medex_00045437-RA	3	MetaCyc: PWY-6348;KEGG: 00740+3.1.3.2;KEGG: 00730+3.1.3.2	"Phosphate acquisition";"Riboflavin metabolism";"Thiamine metabolism"
Medex_00003339-RA	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
Medex_00016070-RA	1	Reactome: R-HSA-163560	"Triglyceride catabolism"
Medex_00056811-RA	33	Reactome: R-HSA-159230;Reactome: R-HSA-5663220;Reactome: R-HSA-2467813;Reactome: R-HSA-1169408;Reactome: R-HSA-168333;Reactome: R-HSA-159227;Reactome: R-HSA-9648025;Reactome: R-HSA-159231;Reactome: R-HSA-68877;Reactome: R-HSA-4551638;Reactome: R-HSA-168325;Reactome: R-HSA-191859;Reactome: R-HSA-141444;Reactome: R-HSA-3232142;Reactome: R-HSA-168271;Reactome: R-HSA-170822;Reactome: R-HSA-3371453;Reactome: R-HSA-4615885;Reactome: R-HSA-168276;Reactome: R-HSA-5578749;Reactome: R-HSA-2500257;Reactome: R-HSA-165054;Reactome: R-HSA-180746;Reactome: R-HSA-9609690;Reactome: R-HSA-5619107;Reactome: R-HSA-9610379;Reactome: R-HSA-159236;Reactome: R-HSA-3108214;Reactome: R-HSA-6784531;Reactome: R-HSA-3301854;Reactome: R-HSA-180910;Reactome: R-HSA-4570464;Reactome: R-HSA-4085377	"Transport of the SLBP Dependant Mature mRNA";"RHO GTPases Activate Formins";"Separation of Sister Chromatids";"ISG15 antiviral mechanism";"NEP/NS2 Interacts with the Cellular Export Machinery";"Transport of the SLBP independent Mature mRNA";"EML4 and NUDC in mitotic spindle formation";"Transport of Mature mRNA Derived from an Intronless Transcript";"Mitotic Prometaphase";"SUMOylation of chromatin organization proteins";"Viral Messenger RNA Synthesis";"snRNP Assembly";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"SUMOylation of ubiquitinylation proteins";"Transport of Ribonucleoproteins into the Host Nucleus";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Regulation of HSF1-mediated heat shock response";"SUMOylation of DNA replication proteins";"NS1 Mediated Effects on Host Pathways";"Transcriptional regulation by small RNAs";"Resolution of Sister Chromatid Cohesion";"Rev-mediated nuclear export of HIV RNA";"Nuclear import of Rev protein";"HCMV Early Events";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"HCMV Late Events";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"SUMOylation of DNA damage response and repair proteins";"tRNA processing in the nucleus";"Nuclear Pore Complex (NPC) Disassembly";"Vpr-mediated nuclear import of PICs";"SUMOylation of RNA binding proteins";"SUMOylation of SUMOylation proteins"
Medex_00050428-RA	1	Reactome: R-HSA-500753	"Pyrimidine biosynthesis"
Medex_00075313-RA	1	Reactome: R-HSA-9640463	"Wax biosynthesis"
Medex_00006068-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Medex_00054309-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00004432-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00087102-RA	1	Reactome: R-HSA-209968	"Thyroxine biosynthesis"
Medex_00031672-RA	2	Reactome: R-HSA-611105;Reactome: R-HSA-5628897	"Respiratory electron transport";"TP53 Regulates Metabolic Genes"
Medex_00035938-RA	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
Medex_00071056-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00033159-RA	2	Reactome: R-HSA-72163;Reactome: R-HSA-72165	"mRNA Splicing - Major Pathway";"mRNA Splicing - Minor Pathway"
Medex_00048212-RA	4	Reactome: R-HSA-72163;Reactome: R-HSA-73856;Reactome: R-HSA-72187;Reactome: R-HSA-159236	"mRNA Splicing - Major Pathway";"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing";"Transport of Mature mRNA derived from an Intron-Containing Transcript"
Medex_00022550-RA	56	Reactome: R-HSA-195253;Reactome: R-HSA-75815;Reactome: R-HSA-8939902;Reactome: R-HSA-4608870;Reactome: R-HSA-5689603;Reactome: R-HSA-5668541;Reactome: R-HSA-5687128;Reactome: R-HSA-5689880;Reactome: R-HSA-5610785;Reactome: R-HSA-180534;Reactome: R-HSA-349425;Reactome: R-HSA-1236978;Reactome: R-HSA-5632684;Reactome: R-HSA-174178;Reactome: R-HSA-8852276;Reactome: R-HSA-5610780;Reactome: R-HSA-5607761;Reactome: R-HSA-202424;Reactome: R-HSA-983168;Reactome: R-HSA-5358346;Reactome: R-HSA-8941858;Reactome: R-HSA-5658442;Reactome: R-HSA-9020702;Reactome: R-HSA-450408;Reactome: R-HSA-180585;Reactome: R-HSA-2467813;Reactome: R-HSA-4641258;Reactome: R-HSA-68949;Reactome: R-HSA-8939236;Reactome: R-HSA-382556;Reactome: R-HSA-211733;Reactome: R-HSA-9010553;Reactome: R-HSA-4641257;Reactome: R-HSA-174113;Reactome: R-HSA-350562;Reactome: R-HSA-5678895;Reactome: R-HSA-69481;Reactome: R-HSA-9604323;Reactome: R-HSA-8948751;Reactome: R-HSA-68827;Reactome: R-HSA-5676590;Reactome: R-HSA-69017;Reactome: R-HSA-5362768;Reactome: R-HSA-1234176;Reactome: R-HSA-69601;Reactome: R-HSA-174184;Reactome: R-HSA-5607764;Reactome: R-HSA-174154;Reactome: R-HSA-1169091;Reactome: R-HSA-2871837;Reactome: R-HSA-8951664;Reactome: R-HSA-174084;Reactome: R-HSA-187577;Reactome: R-HSA-8854050;Reactome: R-HSA-1236974;Reactome: R-HSA-5610783	"Degradation of beta-catenin by the destruction complex";"Ubiquitin-dependent degradation of Cyclin D";"Regulation of RUNX2 expression and activity";"Asymmetric localization of PCP proteins";"UCH proteinases";"TNFR2 non-canonical NF-kB pathway";"MAPK6/MAPK4 signaling";"Ub-specific processing proteases";"GLI3 is processed to GLI3R by the proteasome";"Vpu mediated degradation of CD4";"Autodegradation of the E3 ubiquitin ligase COP1";"Cross-presentation of soluble exogenous antigens (endosomes)";"Hedgehog 'on' state";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Degradation of GLI1 by the proteasome";"Dectin-1 mediated noncanonical NF-kB signaling";"Downstream TCR signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Hedgehog ligand biogenesis";"Regulation of RUNX3 expression and activity";"Regulation of RAS by GAPs";"Interleukin-1 signaling";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Vif-mediated degradation of APOBEC3G";"Separation of Sister Chromatids";"Degradation of DVL";"Orc1 removal from chromatin";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"ABC-family proteins mediated transport";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Regulation of expression of SLITs and ROBOs";"Degradation of AXIN";"SCF-beta-TrCP mediated degradation of Emi1";"Regulation of ornithine decarboxylase (ODC)";"Defective CFTR causes cystic fibrosis";"G2/M Checkpoints";"Negative regulation of NOTCH4 signaling";"Regulation of PTEN stability and activity";"CDT1 association with the CDC6:ORC:origin complex";"NIK-->noncanonical NF-kB signaling";"CDK-mediated phosphorylation and removal of Cdc6";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"CLEC7A (Dectin-1) signaling";"APC/C:Cdc20 mediated degradation of Securin";"Activation of NF-kappaB in B cells";"FCERI mediated NF-kB activation";"Neddylation";"Autodegradation of Cdh1 by Cdh1:APC/C";"SCF(Skp2)-mediated degradation of p27/p21";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"ER-Phagosome pathway";"Degradation of GLI2 by the proteasome"
Medex_00004070-RA	8	KEGG: 00524+2.7.1.1;KEGG: 00010+2.7.1.1;KEGG: 00051+2.7.1.1;KEGG: 00520+2.7.1.1;Reactome: R-HSA-70171;KEGG: 00052+2.7.1.1;KEGG: 00521+2.7.1.1;KEGG: 00500+2.7.1.1	"Neomycin, kanamycin and gentamicin biosynthesis";"Glycolysis / Gluconeogenesis";"Fructose and mannose metabolism";"Amino sugar and nucleotide sugar metabolism";"Glycolysis";"Galactose metabolism";"Streptomycin biosynthesis";"Starch and sucrose metabolism"
Medex_00087657-RA	10	Reactome: R-HSA-438066;Reactome: R-HSA-9617324;Reactome: R-HSA-442982;Reactome: R-HSA-9609736;Reactome: R-HSA-5673001;Reactome: R-HSA-447038;Reactome: R-HSA-399719;Reactome: R-HSA-9620244;Reactome: R-HSA-451308;Reactome: R-HSA-8849932	"Unblocking of NMDA receptors, glutamate binding and activation";"Negative regulation of NMDA receptor-mediated neuronal transmission";"Ras activation upon Ca2+ influx through NMDA receptor";"Assembly and cell surface presentation of NMDA receptors";"RAF/MAP kinase cascade";"NrCAM interactions";"Trafficking of AMPA receptors";"Long-term potentiation";"Activation of Ca-permeable Kainate Receptor";"Synaptic adhesion-like molecules"
Medex_00001242-RA	2	KEGG: 00500+3.2.1.4;MetaCyc: PWY-6788	"Starch and sucrose metabolism";"Cellulose degradation II (fungi)"
Medex_00075472-RA	3	MetaCyc: PWY-5491;KEGG: 00790+3.1.3.1;KEGG: 00730+3.1.3.1	"Diethylphosphate degradation";"Folate biosynthesis";"Thiamine metabolism"
Medex_00002175-RA	1	Reactome: R-HSA-6784531	"tRNA processing in the nucleus"
Medex_00065060-RA	5	Reactome: R-HSA-983189;Reactome: R-HSA-1445148;Reactome: R-HSA-5620924;Reactome: R-HSA-6811434;Reactome: R-HSA-2132295	"Kinesins";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Intraflagellar transport";"COPI-dependent Golgi-to-ER retrograde traffic";"MHC class II antigen presentation"
Medex_00022673-RA	6	KEGG: 00380+1.11.1.6;Reactome: R-HSA-9615017;Reactome: R-HSA-3299685;Reactome: R-HSA-6798695;KEGG: 00630+1.11.1.6;Reactome: R-HSA-9033241	"Tryptophan metabolism";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"Detoxification of Reactive Oxygen Species";"Neutrophil degranulation";"Glyoxylate and dicarboxylate metabolism";"Peroxisomal protein import"
Medex_00000014-RA	5	Reactome: R-HSA-6798695;Reactome: R-HSA-2132295;Reactome: R-HSA-4341670;Reactome: R-HSA-4085001;Reactome: R-HSA-1660662	"Neutrophil degranulation";"MHC class II antigen presentation";"Defective NEU1 causes sialidosis";"Sialic acid metabolism";"Glycosphingolipid metabolism"
Medex_00036168-RA	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
Medex_00032686-RA	14	MetaCyc: PWY-6433;MetaCyc: PWY-7036;MetaCyc: PWY-7619;MetaCyc: PWY-7602;MetaCyc: PWY-5972;MetaCyc: PWY-7035;Reactome: R-HSA-75876;MetaCyc: PWY-7724;MetaCyc: PWY-7601;MetaCyc: PWY-6598;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7725;MetaCyc: PWY-5080;MetaCyc: PWY-8041	"Hydroxylated fatty acid biosynthesis (plants)";"Very long chain fatty acid biosynthesis II";"Juniperonate biosynthesis";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Stearate biosynthesis I (animals)";"(9Z)-tricosene biosynthesis";"Synthesis of very long-chain fatty acyl-CoAs";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Sciadonate biosynthesis";"Fatty acid elongation";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Very long chain fatty acid biosynthesis I";"Ultra-long-chain fatty acid biosynthesis"
Medex_00081761-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00034249-RA	1	Reactome: R-HSA-70221	"Glycogen breakdown (glycogenolysis)"
Medex_00056248-RA	2	Reactome: R-HSA-1369062;Reactome: R-HSA-9603798	"ABC transporters in lipid homeostasis";"Class I peroxisomal membrane protein import"
Medex_00090731-RA	2	MetaCyc: PWY-6829;Reactome: R-HSA-6782315	"Trna methylation (yeast)";"tRNA modification in the nucleus and cytosol"
Medex_00021199-RA	2	Reactome: R-HSA-418990;Reactome: R-HSA-5218920	"Adherens junctions interactions";"VEGFR2 mediated vascular permeability"
Medex_00014621-RA	2	Reactome: R-HSA-8949664;Reactome: R-HSA-8949215	"Processing of SMDT1";"Mitochondrial calcium ion transport"
Medex_00014513-RA	2	Reactome: R-HSA-1660662;Reactome: R-HSA-390471	"Glycosphingolipid metabolism";"Association of TriC/CCT with target proteins during biosynthesis"
Medex_00067158-RA	3	Reactome: R-HSA-6811438;Reactome: R-HSA-6811440;Reactome: R-HSA-6807878	"Intra-Golgi traffic";"Retrograde transport at the Trans-Golgi-Network";"COPI-mediated anterograde transport"
Medex_00066634-RA	5	KEGG: 00230+6.3.3.1;MetaCyc: PWY-6121;Reactome: R-HSA-73817;MetaCyc: PWY-6122;MetaCyc: PWY-6277	"Purine metabolism";"5-aminoimidazole ribonucleotide biosynthesis I";"Purine ribonucleoside monophosphate biosynthesis";"5-aminoimidazole ribonucleotide biosynthesis II";"Superpathway of 5-aminoimidazole ribonucleotide biosynthesis"
Medex_00040238-RA	2	Reactome: R-HSA-3214858;Reactome: R-HSA-8939243	"RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"
Medex_00041727-RA	1	KEGG: 00970+6.1.1.7	"Aminoacyl-tRNA biosynthesis"
Medex_00079731-RA	9	MetaCyc: PWY-6142;MetaCyc: PWY-241;MetaCyc: PWY-5743;MetaCyc: PWY-5789;MetaCyc: PWY-7115;Reactome: R-HSA-1475029;MetaCyc: PWY-7117;MetaCyc: PWY-5744;KEGG: 00910+4.2.1.1	"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"C4 photosynthetic carbon assimilation cycle, NADP-ME type";"3-hydroxypropanoate cycle";"3-hydroxypropanoate/4-hydroxybutanate cycle";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"Reversible hydration of carbon dioxide";"C4 photosynthetic carbon assimilation cycle, PEPCK type";"Glyoxylate assimilation";"Nitrogen metabolism"
Medex_00067100-RA	2	Reactome: R-HSA-189085;KEGG: 00500+3.2.1.28	"Digestion of dietary carbohydrate";"Starch and sucrose metabolism"
Medex_00034188-RA	3	Reactome: R-HSA-168142;Reactome: R-HSA-975871;Reactome: R-HSA-5603037	"Toll Like Receptor 10 (TLR10) Cascade";"MyD88 cascade initiated on plasma membrane";"IRAK4 deficiency (TLR5)"
Medex_00001839-RA	1	Reactome: R-HSA-426048	"Arachidonate production from DAG"
Medex_00077496-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00079539-RA	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
Medex_00008644-RA	7	Reactome: R-HSA-9609690;Reactome: R-HSA-5617472;Reactome: R-HSA-8953750;Reactome: R-HSA-2559580;Reactome: R-HSA-3214841;Reactome: R-HSA-8943724;Reactome: R-HSA-212300	"HCMV Early Events";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Transcriptional Regulation by E2F6";"Oxidative Stress Induced Senescence";"PKMTs methylate histone lysines";"Regulation of PTEN gene transcription";"PRC2 methylates histones and DNA"
Medex_00054298-RA	7	KEGG: 00565+3.1.4.4;MetaCyc: PWY-7039;Reactome: R-HSA-1483148;MetaCyc: PWY-3561;Reactome: R-HSA-2029485;KEGG: 00564+3.1.4.4;Reactome: R-HSA-1483166	"Ether lipid metabolism";"Phosphatidate metabolism, as a signaling molecule";"Synthesis of PG";"Choline biosynthesis III";"Role of phospholipids in phagocytosis";"Glycerophospholipid metabolism";"Synthesis of PA"
Medex_00004971-RA	1	Reactome: R-HSA-426117	"Cation-coupled Chloride cotransporters"
Medex_00020631-RA	2	Reactome: R-HSA-5357905;Reactome: R-HSA-5357956	"Regulation of TNFR1 signaling";"TNFR1-induced NFkappaB signaling pathway"
Medex_00051473-RA	26	Reactome: R-HSA-5617472;Reactome: R-HSA-3371568;Reactome: R-HSA-918233;Reactome: R-HSA-9018519;Reactome: R-HSA-1368082;Reactome: R-HSA-3899300;Reactome: R-HSA-2894862;Reactome: R-HSA-933541;Reactome: R-HSA-5621575;Reactome: R-HSA-9614657;Reactome: R-HSA-1234158;Reactome: R-HSA-8866907;Reactome: R-HSA-9013695;Reactome: R-HSA-381340;Reactome: R-HSA-2122947;Reactome: R-HSA-210744;Reactome: R-HSA-400253;Reactome: R-HSA-1989781;Reactome: R-HSA-1912408;Reactome: R-HSA-3214847;Reactome: R-HSA-201722;Reactome: R-HSA-9013508;Reactome: R-HSA-9617629;Reactome: R-HSA-2644606;Reactome: R-HSA-8941856;Reactome: R-HSA-3134973	"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Attenuation phase";"TRAF3-dependent IRF activation pathway";"Estrogen-dependent gene expression";"RORA activates gene expression";"SUMOylation of transcription cofactors";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"TRAF6 mediated IRF7 activation";"CD209 (DC-SIGN) signaling";"FOXO-mediated transcription of cell death genes";"Regulation of gene expression by Hypoxia-inducible Factor";"Activation of the TFAP2 (AP-2) family of transcription factors";"NOTCH4 Intracellular Domain Regulates Transcription";"Transcriptional regulation of white adipocyte differentiation";"NOTCH1 Intracellular Domain Regulates Transcription";"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"Circadian Clock";"PPARA activates gene expression";"Pre-NOTCH Transcription and Translation";"HATs acetylate histones";"Formation of the beta-catenin:TCF transactivating complex";"NOTCH3 Intracellular Domain Regulates Transcription";"Regulation of FOXO transcriptional activity by acetylation";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"RUNX3 regulates NOTCH signaling";"LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production"
Medex_00006312-RA	3	Reactome: R-HSA-5663213;Reactome: R-HSA-2029482;Reactome: R-HSA-4420097	"RHO GTPases Activate WASPs and WAVEs";"Regulation of actin dynamics for phagocytic cup formation";"VEGFA-VEGFR2 Pathway"
Medex_00030666-RA	13	Reactome: R-HSA-6791226;Reactome: R-HSA-2408557;Reactome: R-HSA-72764;Reactome: R-HSA-72689;Reactome: R-HSA-72706;Reactome: R-HSA-975956;Reactome: R-HSA-156902;Reactome: R-HSA-9633012;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-1799339;Reactome: R-HSA-192823;Reactome: R-HSA-975957	"Major pathway of rRNA processing in the nucleolus and cytosol";"Selenocysteine synthesis";"Eukaryotic Translation Termination";"Formation of a pool of free 40S subunits";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Peptide chain elongation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"SRP-dependent cotranslational protein targeting to membrane";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
Medex_00045923-RA	13	Reactome: R-HSA-975957;Reactome: R-HSA-192823;Reactome: R-HSA-1799339;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-156902;Reactome: R-HSA-9633012;Reactome: R-HSA-975956;Reactome: R-HSA-72706;Reactome: R-HSA-72689;Reactome: R-HSA-72764;Reactome: R-HSA-2408557;Reactome: R-HSA-6791226	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Viral mRNA Translation";"SRP-dependent cotranslational protein targeting to membrane";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Peptide chain elongation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Formation of a pool of free 40S subunits";"Eukaryotic Translation Termination";"Selenocysteine synthesis";"Major pathway of rRNA processing in the nucleolus and cytosol"
Medex_00031227-RA	1	Reactome: R-HSA-5620912	"Anchoring of the basal body to the plasma membrane"
Medex_00078517-RA	3	Reactome: R-HSA-5620916;Reactome: R-HSA-264876;Reactome: R-HSA-1445148	"VxPx cargo-targeting to cilium";"Insulin processing";"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
Medex_00091884-RA	3	Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-212436	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"Generic Transcription Pathway"
Medex_00032891-RA	6	KEGG: 00600+3.2.1.23;KEGG: 00511+3.2.1.23;MetaCyc: PWY-6807;KEGG: 00604+3.2.1.23;KEGG: 00052+3.2.1.23;KEGG: 00531+3.2.1.23	"Sphingolipid metabolism";"Other glycan degradation";"Xyloglucan degradation II (exoglucanase)";"Glycosphingolipid biosynthesis - ganglio series";"Galactose metabolism";"Glycosaminoglycan degradation"
Medex_00010809-RA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00054595-RA	1	Reactome: R-HSA-1971475	"A tetrasaccharide linker sequence is required for GAG synthesis"
Medex_00027621-RA	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5419276;Reactome: R-HSA-5389840	"Mitochondrial translation initiation";"Mitochondrial translation termination";"Mitochondrial translation elongation"
Medex_00064636-RA	2	Reactome: R-HSA-6798695;Reactome: R-HSA-936837	"Neutrophil degranulation";"Ion transport by P-type ATPases"
Medex_00014417-RA	1	Reactome: R-HSA-388844	"Receptor-type tyrosine-protein phosphatases"
Medex_00061149-RA	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
Medex_00034238-RA	2	Reactome: R-HSA-2672351;Reactome: R-HSA-5578775	"Stimuli-sensing channels";"Ion homeostasis"
Medex_00068724-RA	1	Reactome: R-HSA-191859	"snRNP Assembly"
Medex_00048544-RA	4	Reactome: R-HSA-446388;Reactome: R-HSA-114608;Reactome: R-HSA-3000170;Reactome: R-HSA-373753	"Regulation of cytoskeletal remodeling and cell spreading by IPP complex components";"Platelet degranulation";"Syndecan interactions";"Nephrin family interactions"
Medex_00076722-RA	1	Reactome: R-HSA-1474228	"Degradation of the extracellular matrix"
Medex_00095649-RA	8	Reactome: R-HSA-4086398;Reactome: R-HSA-4641263;Reactome: R-HSA-373080;Reactome: R-HSA-8856825;Reactome: R-HSA-5340588;Reactome: R-HSA-8856828;Reactome: R-HSA-4608870;Reactome: R-HSA-5099900	"Ca2+ pathway";"Regulation of FZD by ubiquitination";"Class B/2 (Secretin family receptors)";"Cargo recognition for clathrin-mediated endocytosis";"RNF mutants show enhanced WNT signaling and proliferation";"Clathrin-mediated endocytosis";"Asymmetric localization of PCP proteins";"WNT5A-dependent internalization of FZD4"
Medex_00033442-RA	17	MetaCyc: PWY-7224;MetaCyc: PWY-6545;MetaCyc: PWY-7222;MetaCyc: PWY-7176;MetaCyc: PWY-7184;MetaCyc: PWY-7187;MetaCyc: PWY-7210;KEGG: 00240+2.7.4.6;MetaCyc: PWY-7221;KEGG: 00983+2.7.4.6;MetaCyc: PWY-7205;MetaCyc: PWY-7198;MetaCyc: PWY-7227;MetaCyc: PWY-7226;KEGG: 00230+2.7.4.6;MetaCyc: PWY-7197;MetaCyc: PWY-7220	"Purine deoxyribonucleosides salvage";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Guanosine deoxyribonucleotides de novo biosynthesis II";"UTP and CTP de novo biosynthesis";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Pyrimidine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Pyrimidine metabolism";"Guanosine ribonucleotides de novo biosynthesis";"Drug metabolism - other enzymes";"CMP phosphorylation";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Adenosine deoxyribonucleotides de novo biosynthesis";"Guanosine deoxyribonucleotides de novo biosynthesis I";"Purine metabolism";"Pyrimidine deoxyribonucleotide phosphorylation";"Adenosine deoxyribonucleotides de novo biosynthesis II"
Medex_00004652-RA	5	Reactome: R-HSA-390471;Reactome: R-HSA-6814122;Reactome: R-HSA-389957;Reactome: R-HSA-389960;Reactome: R-HSA-390450	"Association of TriC/CCT with target proteins during biosynthesis";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"Prefoldin mediated transfer of substrate to CCT/TriC";"Formation of tubulin folding intermediates by CCT/TriC";"Folding of actin by CCT/TriC"
Medex_00004528-RA	1	Reactome: R-HSA-72165	"mRNA Splicing - Minor Pathway"
Medex_00059445-RA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
Medex_00001659-RA	20	MetaCyc: PWY-7337;MetaCyc: PWY-7574;KEGG: 00071+1.3.3.6;MetaCyc: PWY-7338;MetaCyc: PWY-7007;MetaCyc: PWY-7291;MetaCyc: PWY-5136;MetaCyc: PWY-6920;KEGG: 00410+1.3.3.6;MetaCyc: PWY-7288;MetaCyc: PWY-7854;KEGG: 00592+1.3.3.6;MetaCyc: PWY-7726;MetaCyc: PWY-735;MetaCyc: PWY-7606;MetaCyc: PWY-6837;MetaCyc: PWY-7858;Reactome: R-HSA-9033241;KEGG: 00640+1.3.3.6;MetaCyc: PWY-7340	"10-cis-heptadecenoyl-CoA degradation (yeast)";"Propanoyl-coa degradation II";"Fatty acid degradation";"10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast)";"Methyl ketone biosynthesis (engineered)";"Oleate beta-oxidation (isomerase-dependent, yeast)";"Fatty acid beta-oxidation II (plant peroxisome)";"6-gingerol analog biosynthesis (engineered)";"beta-Alanine metabolism";"Fatty acid beta-oxidation VII (yeast peroxisome)";"Crotonyl-coa/ethylmalonyl-coa/hydroxybutyryl-coa cycle (engineered)";"alpha-Linolenic acid metabolism";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"Jasmonic acid biosynthesis";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Fatty acid beta-oxidation V (unsaturated, odd number, di-isomerase-dependent)";"(5Z)-dodecenoate biosynthesis II";"Peroxisomal protein import";"Propanoate metabolism";"9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast)"
Medex_00017814-RA	1	Reactome: R-HSA-8856828	"Clathrin-mediated endocytosis"
Medex_00088128-RA	57	Reactome: R-HSA-9010553;Reactome: R-HSA-68949;Reactome: R-HSA-8939236;Reactome: R-HSA-382556;Reactome: R-HSA-211733;Reactome: R-HSA-4641258;Reactome: R-HSA-2467813;Reactome: R-HSA-180585;Reactome: R-HSA-450408;Reactome: R-HSA-9020702;Reactome: R-HSA-6798695;Reactome: R-HSA-5658442;Reactome: R-HSA-8941858;Reactome: R-HSA-5358346;Reactome: R-HSA-983168;Reactome: R-HSA-202424;Reactome: R-HSA-5607761;Reactome: R-HSA-5610780;Reactome: R-HSA-8852276;Reactome: R-HSA-174178;Reactome: R-HSA-5632684;Reactome: R-HSA-1236978;Reactome: R-HSA-349425;Reactome: R-HSA-180534;Reactome: R-HSA-5610785;Reactome: R-HSA-5689880;Reactome: R-HSA-5689603;Reactome: R-HSA-5687128;Reactome: R-HSA-5668541;Reactome: R-HSA-4608870;Reactome: R-HSA-8939902;Reactome: R-HSA-75815;Reactome: R-HSA-195253;Reactome: R-HSA-5610783;Reactome: R-HSA-1236974;Reactome: R-HSA-8854050;Reactome: R-HSA-187577;Reactome: R-HSA-174084;Reactome: R-HSA-8951664;Reactome: R-HSA-2871837;Reactome: R-HSA-1169091;Reactome: R-HSA-174154;Reactome: R-HSA-174184;Reactome: R-HSA-5607764;Reactome: R-HSA-5362768;Reactome: R-HSA-1234176;Reactome: R-HSA-69017;Reactome: R-HSA-69601;Reactome: R-HSA-5676590;Reactome: R-HSA-8948751;Reactome: R-HSA-9604323;Reactome: R-HSA-68827;Reactome: R-HSA-5678895;Reactome: R-HSA-350562;Reactome: R-HSA-69481;Reactome: R-HSA-174113;Reactome: R-HSA-4641257	"Regulation of expression of SLITs and ROBOs";"Orc1 removal from chromatin";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"ABC-family proteins mediated transport";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Degradation of DVL";"Separation of Sister Chromatids";"Vif-mediated degradation of APOBEC3G";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Interleukin-1 signaling";"Neutrophil degranulation";"Regulation of RAS by GAPs";"Regulation of RUNX3 expression and activity";"Hedgehog ligand biogenesis";"Antigen processing: Ubiquitination & Proteasome degradation";"Downstream TCR signaling";"Dectin-1 mediated noncanonical NF-kB signaling";"Degradation of GLI1 by the proteasome";"The role of GTSE1 in G2/M progression after G2 checkpoint";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Hedgehog 'on' state";"Cross-presentation of soluble exogenous antigens (endosomes)";"Autodegradation of the E3 ubiquitin ligase COP1";"Vpu mediated degradation of CD4";"GLI3 is processed to GLI3R by the proteasome";"Ub-specific processing proteases";"UCH proteinases";"MAPK6/MAPK4 signaling";"TNFR2 non-canonical NF-kB pathway";"Asymmetric localization of PCP proteins";"Regulation of RUNX2 expression and activity";"Ubiquitin-dependent degradation of Cyclin D";"Degradation of beta-catenin by the destruction complex";"Degradation of GLI2 by the proteasome";"ER-Phagosome pathway";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"SCF(Skp2)-mediated degradation of p27/p21";"Autodegradation of Cdh1 by Cdh1:APC/C";"Neddylation";"FCERI mediated NF-kB activation";"Activation of NF-kappaB in B cells";"APC/C:Cdc20 mediated degradation of Securin";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"CLEC7A (Dectin-1) signaling";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"CDK-mediated phosphorylation and removal of Cdc6";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"NIK-->noncanonical NF-kB signaling";"Regulation of PTEN stability and activity";"Negative regulation of NOTCH4 signaling";"CDT1 association with the CDC6:ORC:origin complex";"Defective CFTR causes cystic fibrosis";"Regulation of ornithine decarboxylase (ODC)";"G2/M Checkpoints";"SCF-beta-TrCP mediated degradation of Emi1";"Degradation of AXIN"
Medex_00100725-RA	1	Reactome: R-HSA-1632852	"Macroautophagy"
Medex_00042786-RA	10	Reactome: R-HSA-166016;Reactome: R-HSA-177504;Reactome: R-HSA-432722;Reactome: R-HSA-196025;Reactome: R-HSA-437239;Reactome: R-HSA-190873;Reactome: R-HSA-8856828;Reactome: R-HSA-2132295;Reactome: R-HSA-432720;Reactome: R-HSA-203641	"Toll Like Receptor 4 (TLR4) Cascade";"Retrograde neurotrophin signalling";"Golgi Associated Vesicle Biogenesis";"Formation of annular gap junctions";"Recycling pathway of L1";"Gap junction degradation";"Clathrin-mediated endocytosis";"MHC class II antigen presentation";"Lysosome Vesicle Biogenesis";"NOSTRIN mediated eNOS trafficking"
Medex_00089248-RA	18	Reactome: R-HSA-6802946;Reactome: R-HSA-9649948;Reactome: R-HSA-354192;Reactome: R-HSA-210990;Reactome: R-HSA-3000170;Reactome: R-HSA-3000178;Reactome: R-HSA-445144;Reactome: R-HSA-354194;Reactome: R-HSA-5674135;Reactome: R-HSA-6802948;Reactome: R-HSA-114608;Reactome: R-HSA-2129379;Reactome: R-HSA-216083;Reactome: R-HSA-6802955;Reactome: R-HSA-4420097;Reactome: R-HSA-6802952;Reactome: R-HSA-372708;Reactome: R-HSA-1566948	"Signaling by moderate kinase activity BRAF mutants";"Signaling downstream of RAS mutants";"Integrin signaling";"PECAM1 interactions";"Syndecan interactions";"ECM proteoglycans";"Signal transduction by L1";"GRB2:SOS provides linkage to MAPK signaling for Integrins";"MAP2K and MAPK activation";"Signaling by high-kinase activity BRAF mutants";"Platelet degranulation";"Molecules associated with elastic fibres";"Integrin cell surface interactions";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"VEGFA-VEGFR2 Pathway";"Signaling by BRAF and RAF fusions";"p130Cas linkage to MAPK signaling for integrins";"Elastic fibre formation"
Medex_00036126-RA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00096206-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Medex_00031464-RA	1	Reactome: R-HSA-203927	"MicroRNA (miRNA) biogenesis"
Medex_00016265-RA	5	Reactome: R-HSA-1660662;Reactome: R-HSA-4085001;Reactome: R-HSA-4341670;Reactome: R-HSA-2132295;Reactome: R-HSA-6798695	"Glycosphingolipid metabolism";"Sialic acid metabolism";"Defective NEU1 causes sialidosis";"MHC class II antigen presentation";"Neutrophil degranulation"
Medex_00044600-RA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Medex_00021702-RA	1	Reactome: R-HSA-977225	"Amyloid fiber formation"
Medex_00036691-RA	2	Reactome: R-HSA-3214858;Reactome: R-HSA-8939243	"RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"
Medex_00051634-RA	5	Reactome: R-HSA-8856828;Reactome: R-HSA-6798695;Reactome: R-HSA-6811440;Reactome: R-HSA-432722;Reactome: R-HSA-8856825	"Clathrin-mediated endocytosis";"Neutrophil degranulation";"Retrograde transport at the Trans-Golgi-Network";"Golgi Associated Vesicle Biogenesis";"Cargo recognition for clathrin-mediated endocytosis"
Medex_00052842-RA	1	Reactome: R-HSA-1483101	"Synthesis of PS"
Medex_00069457-RA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00005024-RA	2	Reactome: R-HSA-446193;Reactome: R-HSA-4570571	"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"Defective RFT1 causes RFT1-CDG (CDG-1n)"
Medex_00002706-RA	1	Reactome: R-HSA-8951664	"Neddylation"
Medex_00075127-RA	2	Reactome: R-HSA-2132295;Reactome: R-HSA-877300	"MHC class II antigen presentation";"Interferon gamma signaling"
Medex_00059011-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Medex_00029563-RA	1	Reactome: R-HSA-3214842	"HDMs demethylate histones"
Medex_00085669-RA	1	Reactome: R-HSA-156584	"Cytosolic sulfonation of small molecules"
Medex_00029431-RA	2	Reactome: R-HSA-5689603;Reactome: R-HSA-5689880	"UCH proteinases";"Ub-specific processing proteases"
Medex_00035017-RA	1	KEGG: 00760+2.3.1.286	"Nicotinate and nicotinamide metabolism"
Medex_00012343-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Medex_00013149-RA	1	Reactome: R-HSA-8849932	"Synaptic adhesion-like molecules"
Medex_00053555-RA	13	MetaCyc: PWY-5122;MetaCyc: PWY-7709;MetaCyc: PWY-5123;MetaCyc: PWY-7736;MetaCyc: PWY-7102;MetaCyc: PWY-7410;MetaCyc: PWY-6383;KEGG: 00900+2.5.1.10+2.5.1.1;MetaCyc: PWY-7659;MetaCyc: PWY-7141;MetaCyc: PWY-6859;MetaCyc: PWY-7182;MetaCyc: PWY-7721	"Geranyl diphosphate biosynthesis";"(3R)-linalool biosynthesis";"Trans, trans-farnesyl diphosphate biosynthesis";"Stellatic acid biosynthesis";"Bisabolene biosynthesis (engineered)";"Ipsdienol biosynthesis";"Mono-trans, poly-cis decaprenyl phosphate biosynthesis";"Terpenoid backbone biosynthesis";"Viridicatumtoxin biosynthesis";"(3S)-linalool biosynthesis";"All-trans-farnesol biosynthesis";"Linalool biosynthesis I";"Methyl phomopsenoate biosynthesis"
Medex_00001582-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00033934-RA	5	Reactome: R-HSA-917977;Reactome: R-HSA-1222556;Reactome: R-HSA-9639288;Reactome: R-HSA-77387;Reactome: R-HSA-983712	"Transferrin endocytosis and recycling";"ROS and RNS production in phagocytes";"Amino acids regulate mTORC1";"Insulin receptor recycling";"Ion channel transport"
Medex_00003275-RA	5	MetaCyc: PWY-5667;MetaCyc: PWY-7817;KEGG: 04070+2.7.7.41;MetaCyc: PWY-5981;KEGG: 00564+2.7.7.41	"CDP-diacylglycerol biosynthesis I";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Phosphatidylinositol signaling system";"CDP-diacylglycerol biosynthesis III";"Glycerophospholipid metabolism"
Medex_00071106-RA	4	Reactome: R-HSA-72163;Reactome: R-HSA-77595;Reactome: R-HSA-73856;Reactome: R-HSA-72187	"mRNA Splicing - Major Pathway";"Processing of Intronless Pre-mRNAs";"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing"
Medex_00051200-RA	2	Reactome: R-HSA-446203;Reactome: R-HSA-1799339	"Asparagine N-linked glycosylation";"SRP-dependent cotranslational protein targeting to membrane"
Medex_00072418-RA	1	Reactome: R-HSA-9037629	"Lewis blood group biosynthesis"
Medex_00077656-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Medex_00014151-RA	4	Reactome: R-HSA-1912420;Reactome: R-HSA-418359;Reactome: R-HSA-936837;Reactome: R-HSA-5578775	"Pre-NOTCH Processing in Golgi";"Reduction of cytosolic Ca++ levels";"Ion transport by P-type ATPases";"Ion homeostasis"
Medex_00044090-RA	1	Reactome: R-HSA-429958	"mRNA decay by 3' to 5' exoribonuclease"
Medex_00002387-RA	1	Reactome: R-HSA-432722	"Golgi Associated Vesicle Biogenesis"
Medex_00046045-RA	2	Reactome: R-HSA-425561;Reactome: R-HSA-5619055	"Sodium/Calcium exchangers";"Defective SLC24A4 causes hypomineralized amelogenesis imperfecta (AI)"
Medex_00040571-RA	13	Reactome: R-HSA-3928662;KEGG: 04714+2.7.11.1;Reactome: R-HSA-416482;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05163+2.7.11.1;Reactome: R-HSA-194840;KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1;Reactome: R-HSA-193648;Reactome: R-HSA-5687128;Reactome: R-HSA-416476	"EPHB-mediated forward signaling";"Thermogenesis";"G alpha (12/13) signalling events";"mTOR signaling pathway";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Human cytomegalovirus infection";"Rho GTPase cycle";"Relaxin signaling pathway";"PI3K-Akt signaling pathway";"NRAGE signals death through JNK";"MAPK6/MAPK4 signaling";"G alpha (q) signalling events"
Medex_00072506-RA	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
Medex_00067530-RA	2	KEGG: 00480+1.11.1.15;Reactome: R-HSA-3299685	"Glutathione metabolism";"Detoxification of Reactive Oxygen Species"
Medex_00021364-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Medex_00040073-RA	3	Reactome: R-HSA-3000171;Reactome: R-HSA-8874081;Reactome: R-HSA-3000157	"Non-integrin membrane-ECM interactions";"MET activates PTK2 signaling";"Laminin interactions"
Medex_00055110-RA	1	Reactome: R-HSA-71403	"Citric acid cycle (TCA cycle)"
Medex_00057589-RA	4	Reactome: R-HSA-3371497;Reactome: R-HSA-8939211;Reactome: R-HSA-9018519;Reactome: R-HSA-3371568	"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"ESR-mediated signaling";"Estrogen-dependent gene expression";"Attenuation phase"
Medex_00011596-RA	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5419276;Reactome: R-HSA-5368286	"Mitochondrial translation elongation";"Mitochondrial translation termination";"Mitochondrial translation initiation"
Medex_00024671-RA	3	MetaCyc: PWY-6348;KEGG: 00740+3.1.3.2;KEGG: 00730+3.1.3.2	"Phosphate acquisition";"Riboflavin metabolism";"Thiamine metabolism"
Medex_00091690-RA	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
Medex_00022405-RA	5	MetaCyc: PWY-3821;KEGG: 00052+2.7.1.6;MetaCyc: PWY-6527;KEGG: 00520+2.7.1.6;MetaCyc: PWY-6317	"D-galactose detoxification";"Galactose metabolism";"Stachyose degradation";"Amino sugar and nucleotide sugar metabolism";"D-galactose degradation I (Leloir pathway)"
Medex_00039886-RA	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
Medex_00024166-RA	1	MetaCyc: PWY-7533	"Gliotoxin biosynthesis"
Medex_00011491-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00070549-RA	1	Reactome: R-HSA-373080	"Class B/2 (Secretin family receptors)"
Medex_00021423-RA	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
Medex_00020688-RA	6	Reactome: R-HSA-72695;Reactome: R-HSA-156827;Reactome: R-HSA-72649;Reactome: R-HSA-72702;Reactome: R-HSA-72689;Reactome: R-HSA-72706	"Formation of the ternary complex, and subsequently, the 43S complex";"L13a-mediated translational silencing of Ceruloplasmin expression";"Translation initiation complex formation";"Ribosomal scanning and start codon recognition";"Formation of a pool of free 40S subunits";"GTP hydrolysis and joining of the 60S ribosomal subunit"
Medex_00020591-RA	3	Reactome: R-HSA-74259;Reactome: R-HSA-73621;Reactome: R-HSA-196807	"Purine catabolism";"Pyrimidine catabolism";"Nicotinate metabolism"
Medex_00035717-RA	1	Reactome: R-HSA-432720	"Lysosome Vesicle Biogenesis"
Medex_00066098-RA	1	Reactome: R-HSA-373080	"Class B/2 (Secretin family receptors)"
Medex_00069138-RA	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
Medex_00080422-RA	1	Reactome: R-HSA-6805567	"Keratinization"
Medex_00086057-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Medex_00023491-RA	5	Reactome: R-HSA-6782210;Reactome: R-HSA-6781827;Reactome: R-HSA-72163;Reactome: R-HSA-6781823;Reactome: R-HSA-6782135	"Gap-filling DNA repair synthesis and ligation in TC-NER";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"mRNA Splicing - Major Pathway";"Formation of TC-NER Pre-Incision Complex";"Dual incision in TC-NER"
Medex_00080926-RA	11	Reactome: R-HSA-1368108;Reactome: R-HSA-2426168;Reactome: R-HSA-381340;Reactome: R-HSA-2151201;Reactome: R-HSA-383280;Reactome: R-HSA-212436;Reactome: R-HSA-1989781;Reactome: R-HSA-400253;Reactome: R-HSA-1368082;Reactome: R-HSA-400206;Reactome: R-HSA-9018519	"BMAL1:CLOCK,NPAS2 activates circadian gene expression";"Activation of gene expression by SREBF (SREBP)";"Transcriptional regulation of white adipocyte differentiation";"Transcriptional activation of mitochondrial biogenesis";"Nuclear Receptor transcription pathway";"Generic Transcription Pathway";"PPARA activates gene expression";"Circadian Clock";"RORA activates gene expression";"Regulation of lipid metabolism by PPARalpha";"Estrogen-dependent gene expression"
Medex_00033226-RA	3	Reactome: R-HSA-4086400;Reactome: R-HSA-373080;Reactome: R-HSA-4608870	"PCP/CE pathway";"Class B/2 (Secretin family receptors)";"Asymmetric localization of PCP proteins"
Medex_00044951-RA	3	Reactome: R-HSA-164843;Reactome: R-HSA-3108214;Reactome: R-HSA-5693571	"2-LTR circle formation";"SUMOylation of DNA damage response and repair proteins";"Nonhomologous End-Joining (NHEJ)"
Medex_00041753-RA	1	Reactome: R-HSA-425381	"Bicarbonate transporters"
Medex_00006166-RA	17	Reactome: R-HSA-975957;Reactome: R-HSA-1799339;Reactome: R-HSA-9633012;Reactome: R-HSA-975956;Reactome: R-HSA-72706;Reactome: R-HSA-72764;Reactome: R-HSA-72702;Reactome: R-HSA-6791226;Reactome: R-HSA-192823;Reactome: R-HSA-72649;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-72695;Reactome: R-HSA-156902;Reactome: R-HSA-72689;Reactome: R-HSA-6790901;Reactome: R-HSA-2408557	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Eukaryotic Translation Termination";"Ribosomal scanning and start codon recognition";"Major pathway of rRNA processing in the nucleolus and cytosol";"Viral mRNA Translation";"Translation initiation complex formation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Formation of the ternary complex, and subsequently, the 43S complex";"Peptide chain elongation";"Formation of a pool of free 40S subunits";"rRNA modification in the nucleus and cytosol";"Selenocysteine synthesis"
Medex_00021201-RA	5	MetaCyc: PWY-6289;MetaCyc: PWY-6012;KEGG: 00770+2.7.8.7;Reactome: R-HSA-199220;MetaCyc: PWY-6012-1	"Petrobactin biosynthesis";"Acyl carrier protein metabolism";"Pantothenate and CoA biosynthesis";"Vitamin B5 (pantothenate) metabolism";"Acyl carrier protein activation"
Medex_00065014-RA	5	Reactome: R-HSA-73772;Reactome: R-HSA-73762;Reactome: R-HSA-73863;Reactome: R-HSA-5250924;Reactome: R-HSA-427413	"RNA Polymerase I Promoter Escape";"RNA Polymerase I Transcription Initiation";"RNA Polymerase I Transcription Termination";"B-WICH complex positively regulates rRNA expression";"NoRC negatively regulates rRNA expression"
Medex_00004878-RA	1	Reactome: R-HSA-186797	"Signaling by PDGF"
Medex_00068832-RA	1	Reactome: R-HSA-211981	"Xenobiotics"
Medex_00059056-RA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00093214-RA	2	Reactome: R-HSA-383280;Reactome: R-HSA-4090294	"Nuclear Receptor transcription pathway";"SUMOylation of intracellular receptors"
Medex_00036962-RA	4	MetaCyc: PWY-6906;Reactome: R-HSA-446210;MetaCyc: PWY-6517;KEGG: 00520+2.7.1.59	"Chitin derivatives degradation";"Synthesis of UDP-N-acetyl-glucosamine";"N-acetylglucosamine degradation II";"Amino sugar and nucleotide sugar metabolism"
Medex_00052425-RA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00037049-RA	5	Reactome: R-HSA-8856825;Reactome: R-HSA-3928665;Reactome: R-HSA-8856828;Reactome: R-HSA-190873;Reactome: R-HSA-196025	"Cargo recognition for clathrin-mediated endocytosis";"EPH-ephrin mediated repulsion of cells";"Clathrin-mediated endocytosis";"Gap junction degradation";"Formation of annular gap junctions"
Medex_00013940-RA	1	Reactome: R-HSA-8876725	"Protein methylation"
Medex_00052722-RA	5	KEGG: 00564+2.7.7.41;MetaCyc: PWY-5981;KEGG: 04070+2.7.7.41;MetaCyc: PWY-7817;MetaCyc: PWY-5667	"Glycerophospholipid metabolism";"CDP-diacylglycerol biosynthesis III";"Phosphatidylinositol signaling system";"Type I lipoteichoic acid biosynthesis (S. aureus)";"CDP-diacylglycerol biosynthesis I"
Medex_00026162-RA	17	Reactome: R-HSA-1834949;Reactome: R-HSA-5685942;Reactome: R-HSA-912446;Reactome: R-HSA-5693554;Reactome: R-HSA-5693616;Reactome: R-HSA-5693548;Reactome: R-HSA-5693571;Reactome: R-HSA-5693607;Reactome: R-HSA-5685938;Reactome: R-HSA-5685939;Reactome: R-HSA-69473;Reactome: R-HSA-6804756;Reactome: R-HSA-5693579;Reactome: R-HSA-3270619;Reactome: R-HSA-5693565;Reactome: R-HSA-5693568;Reactome: R-HSA-2559586	"Cytosolic sensors of pathogen-associated DNA";"HDR through Homologous Recombination (HRR)";"Meiotic recombination";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Presynaptic phase of homologous DNA pairing and strand exchange";"Sensing of DNA Double Strand Breaks";"Nonhomologous End-Joining (NHEJ)";"Processing of DNA double-strand break ends";"HDR through Single Strand Annealing (SSA)";"HDR through MMEJ (alt-NHEJ)";"G2/M DNA damage checkpoint";"Regulation of TP53 Activity through Phosphorylation";"Homologous DNA Pairing and Strand Exchange";"IRF3-mediated induction of type I IFN";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Resolution of D-loop Structures through Holliday Junction Intermediates";"DNA Damage/Telomere Stress Induced Senescence"
Medex_00008646-RA	1	Reactome: R-HSA-6799198	"Complex I biogenesis"
Medex_00017793-RA	3	MetaCyc: PWY-7888;Reactome: R-HSA-6782315;MetaCyc: PWY-6829	"Trna-uridine 2-thiolation (cytoplasmic)";"tRNA modification in the nucleus and cytosol";"Trna methylation (yeast)"
Medex_00030670-RA	2	Reactome: R-HSA-72163;Reactome: R-HSA-72165	"mRNA Splicing - Major Pathway";"mRNA Splicing - Minor Pathway"
Medex_00031538-RA	1	Reactome: R-HSA-6787450	"tRNA modification in the mitochondrion"
Medex_00004348-RA	3	Reactome: R-HSA-1358803;Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Downregulation of ERBB2:ERBB3 signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
Medex_00030241-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Medex_00071247-RA	2	Reactome: R-HSA-6807878;Reactome: R-HSA-445095	"COPI-mediated anterograde transport";"Interaction between L1 and Ankyrins"
Medex_00008375-RA	1	Reactome: R-HSA-352230	"Amino acid transport across the plasma membrane"
Medex_00091827-RA	6	KEGG: 00073+1.2.1.84;MetaCyc: PWY-7782;MetaCyc: PWY-7656;MetaCyc: PWY-6733;Reactome: R-HSA-9640463;MetaCyc: PWY-5884	"Cutin, suberine and wax biosynthesis";"Plasmalogen biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Sporopollenin precursors biosynthesis";"Wax biosynthesis";"Wax esters biosynthesis I"
Medex_00035251-RA	14	MetaCyc: PWY-5690;Reactome: R-HSA-611105;MetaCyc: PWY-7254;KEGG: 00720+1.3.5.1;MetaCyc: PWY-3781;MetaCyc: PWY-6728;KEGG: 00020+1.3.5.1;MetaCyc: PWY-6969;MetaCyc: PWY-561;Reactome: R-HSA-71403;KEGG: 00650+1.3.5.1;MetaCyc: PWY-7279;KEGG: 00190+1.3.5.1;MetaCyc: PWY-4302	"TCA cycle II (plants and fungi)";"Respiratory electron transport";"TCA cycle VII (acetate-producers)";"Carbon fixation pathways in prokaryotes";"Aerobic respiration I (cytochrome c)";"Methylaspartate cycle";"Citrate cycle (TCA cycle)";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Superpathway of glyoxylate cycle and fatty acid degradation";"Citric acid cycle (TCA cycle)";"Butanoate metabolism";"Aerobic respiration II (cytochrome c) (yeast)";"Oxidative phosphorylation";"Aerobic respiration III (alternative oxidase pathway)"
Medex_00082403-RA	13	Reactome: R-HSA-1799339;Reactome: R-HSA-9633012;Reactome: R-HSA-156902;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-975957;Reactome: R-HSA-192823;Reactome: R-HSA-2408557;Reactome: R-HSA-6791226;Reactome: R-HSA-72706;Reactome: R-HSA-975956;Reactome: R-HSA-72689;Reactome: R-HSA-72764	"SRP-dependent cotranslational protein targeting to membrane";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Peptide chain elongation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Viral mRNA Translation";"Selenocysteine synthesis";"Major pathway of rRNA processing in the nucleolus and cytosol";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Formation of a pool of free 40S subunits";"Eukaryotic Translation Termination"
Medex_00059834-RA	6	Reactome: R-HSA-8948751;Reactome: R-HSA-8863795;Reactome: R-HSA-2173788;Reactome: R-HSA-8939902;Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Regulation of PTEN stability and activity";"Downregulation of ERBB2 signaling";"Downregulation of TGF-beta receptor signaling";"Regulation of RUNX2 expression and activity";"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
Medex_00007904-RA	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
Medex_00025609-RA	3	KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway"
Medex_00019647-RA	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
Medex_00038423-RA	3	KEGG: 00860+2.5.1.141;MetaCyc: PWY-7856;Reactome: R-HSA-189451	"Porphyrin and chlorophyll metabolism";"Heme a biosynthesis";"Heme biosynthesis"
Medex_00022233-RA	2	KEGG: 00511+3.2.1.24;Reactome: R-HSA-8853383	"Other glycan degradation";"Lysosomal oligosaccharide catabolism"
Medex_00032927-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00018671-RA	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
Medex_00006240-RA	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
Medex_00078313-RA	2	Reactome: R-HSA-8964038;Reactome: R-HSA-6798695	"LDL clearance";"Neutrophil degranulation"
Medex_00011018-RA	2	Reactome: R-HSA-3214858;Reactome: R-HSA-8939243	"RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"
Medex_00031704-RA	11	Reactome: R-HSA-3656237;Reactome: R-HSA-1971475;Reactome: R-HSA-4420332;Reactome: R-HSA-3656253;Reactome: R-HSA-202733;Reactome: R-HSA-3000170;Reactome: R-HSA-2022928;Reactome: R-HSA-3560783;Reactome: R-HSA-3560801;Reactome: R-HSA-975634;Reactome: R-HSA-2024096	"Defective EXT2 causes exostoses 2";"A tetrasaccharide linker sequence is required for GAG synthesis";"Defective B3GALT6 causes EDSP2 and SEMDJL1";"Defective EXT1 causes exostoses 1, TRPS2 and CHDS";"Cell surface interactions at the vascular wall";"Syndecan interactions";"HS-GAG biosynthesis";"Defective B4GALT7 causes EDS, progeroid type";"Defective B3GAT3 causes JDSSDHD";"Retinoid metabolism and transport";"HS-GAG degradation"
Medex_00093922-RA	2	Reactome: R-HSA-1660662;Reactome: R-HSA-390471	"Glycosphingolipid metabolism";"Association of TriC/CCT with target proteins during biosynthesis"
Medex_00014419-RA	1	Reactome: R-HSA-388844	"Receptor-type tyrosine-protein phosphatases"
Medex_00072417-RA	1	Reactome: R-HSA-9037629	"Lewis blood group biosynthesis"
Medex_00029289-RA	1	Reactome: R-HSA-425381	"Bicarbonate transporters"
Medex_00032442-RA	2	Reactome: R-HSA-6798695;Reactome: R-HSA-8964038	"Neutrophil degranulation";"LDL clearance"
Medex_00030136-RA	22	Reactome: R-HSA-9648025;Reactome: R-HSA-68877;Reactome: R-HSA-5467340;Reactome: R-HSA-2467813;Reactome: R-HSA-5467337;Reactome: R-HSA-5339716;Reactome: R-HSA-5675221;Reactome: R-HSA-5358747;Reactome: R-HSA-2500257;Reactome: R-HSA-5358752;Reactome: R-HSA-5663220;Reactome: R-HSA-196299;Reactome: R-HSA-5673000;Reactome: R-HSA-5467348;Reactome: R-HSA-5358751;Reactome: R-HSA-5358749;Reactome: R-HSA-6811558;Reactome: R-HSA-4641262;Reactome: R-HSA-141444;Reactome: R-HSA-389513;Reactome: R-HSA-195253;Reactome: R-HSA-432142	"EML4 and NUDC in mitotic spindle formation";"Mitotic Prometaphase";"AXIN missense mutants destabilize the destruction complex";"Separation of Sister Chromatids";"APC truncation mutants have impaired AXIN binding";"Misspliced GSK3beta mutants stabilize beta-catenin";"Negative regulation of MAPK pathway";"S33 mutants of beta-catenin aren't phosphorylated";"Resolution of Sister Chromatid Cohesion";"T41 mutants of beta-catenin aren't phosphorylated";"RHO GTPases Activate Formins";"Beta-catenin phosphorylation cascade";"RAF activation";"Truncations of AMER1 destabilize the destruction complex";"S45 mutants of beta-catenin aren't phosphorylated";"S37 mutants of beta-catenin aren't phosphorylated";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"CTLA4 inhibitory signaling";"Degradation of beta-catenin by the destruction complex";"Platelet sensitization by LDL"
Medex_00067148-RA	2	Reactome: R-HSA-8949664;Reactome: R-HSA-8949215	"Processing of SMDT1";"Mitochondrial calcium ion transport"
Medex_00058638-RA	1	Reactome: R-HSA-1632852	"Macroautophagy"
Medex_00012392-RA	2	Reactome: R-HSA-6811438;Reactome: R-HSA-6807878	"Intra-Golgi traffic";"COPI-mediated anterograde transport"
Medex_00021284-RA	1	KEGG: 00970+6.1.1.9	"Aminoacyl-tRNA biosynthesis"
Medex_00001969-RA	6	MetaCyc: PWY-7656;MetaCyc: PWY-7782;MetaCyc: PWY-6733;KEGG: 00073+1.2.1.84;Reactome: R-HSA-9640463;MetaCyc: PWY-5884	"Spodoptera littoralis pheromone biosynthesis";"Plasmalogen biosynthesis";"Sporopollenin precursors biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax biosynthesis";"Wax esters biosynthesis I"
Medex_00016259-RA	4	Reactome: R-HSA-5696400;Reactome: R-HSA-6781823;Reactome: R-HSA-5696395;Reactome: R-HSA-6782135	"Dual Incision in GG-NER";"Formation of TC-NER Pre-Incision Complex";"Formation of Incision Complex in GG-NER";"Dual incision in TC-NER"
Medex_00000887-RA	14	Reactome: R-HSA-674695;Reactome: R-HSA-167152;Reactome: R-HSA-167287;Reactome: R-HSA-167243;Reactome: R-HSA-113418;Reactome: R-HSA-167290;Reactome: R-HSA-167158;Reactome: R-HSA-167242;Reactome: R-HSA-167246;Reactome: R-HSA-167200;Reactome: R-HSA-6796648;Reactome: R-HSA-167238;Reactome: R-HSA-75955;Reactome: R-HSA-112382	"RNA Polymerase II Pre-transcription Events";"Formation of HIV elongation complex in the absence of HIV Tat";"HIV elongation arrest and recovery";"Tat-mediated HIV elongation arrest and recovery";"Formation of the Early Elongation Complex";"Pausing and recovery of HIV elongation";"Formation of the HIV-1 Early Elongation Complex";"Abortive elongation of HIV-1 transcript in the absence of Tat";"Tat-mediated elongation of the HIV-1 transcript";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"TP53 Regulates Transcription of DNA Repair Genes";"Pausing and recovery of Tat-mediated HIV elongation";"RNA Polymerase II Transcription Elongation";"Formation of RNA Pol II elongation complex"
Medex_00075140-RA	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
Medex_00077737-RA	1	Reactome: R-HSA-9033241	"Peroxisomal protein import"
Medex_00006048-RA	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
Medex_00013600-RA	5	Reactome: R-HSA-983168;Reactome: R-HSA-5689877;Reactome: R-HSA-9646399;Reactome: R-HSA-977225;Reactome: R-HSA-5205685	"Antigen processing: Ubiquitination & Proteasome degradation";"Josephin domain DUBs";"Aggrephagy";"Amyloid fiber formation";"Pink/Parkin Mediated Mitophagy"
Medex_00070235-RA	4	Reactome: R-HSA-112043;Reactome: R-HSA-6814122;Reactome: R-HSA-418594;Reactome: R-HSA-202040	"PLC beta mediated events";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"G alpha (i) signalling events";"G-protein activation"
Medex_00014148-RA	4	Reactome: R-HSA-936837;Reactome: R-HSA-5578775;Reactome: R-HSA-418359;Reactome: R-HSA-1912420	"Ion transport by P-type ATPases";"Ion homeostasis";"Reduction of cytosolic Ca++ levels";"Pre-NOTCH Processing in Golgi"
Medex_00034740-RA	5	Reactome: R-HSA-1660662;Reactome: R-HSA-4085001;Reactome: R-HSA-4341670;Reactome: R-HSA-2132295;Reactome: R-HSA-6798695	"Glycosphingolipid metabolism";"Sialic acid metabolism";"Defective NEU1 causes sialidosis";"MHC class II antigen presentation";"Neutrophil degranulation"
Medex_00035160-RA	11	Reactome: R-HSA-5620912;Reactome: R-HSA-6811436;Reactome: R-HSA-6807878;Reactome: R-HSA-3371497;Reactome: R-HSA-2132295;Reactome: R-HSA-2565942;Reactome: R-HSA-8854518;Reactome: R-HSA-380320;Reactome: R-HSA-380284;Reactome: R-HSA-380259;Reactome: R-HSA-380270	"Anchoring of the basal body to the plasma membrane";"COPI-independent Golgi-to-ER retrograde traffic";"COPI-mediated anterograde transport";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"MHC class II antigen presentation";"Regulation of PLK1 Activity at G2/M Transition";"AURKA Activation by TPX2";"Recruitment of NuMA to mitotic centrosomes";"Loss of proteins required for interphase microtubule organization from the centrosome";"Loss of Nlp from mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes"
Medex_00041339-RA	2	MetaCyc: PWY-6854;Reactome: R-HSA-3299685	"Ethylene biosynthesis III (microbes)";"Detoxification of Reactive Oxygen Species"
Medex_00065406-RA	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
Medex_00075832-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00066571-RA	3	MetaCyc: PWY-7159;Reactome: R-HSA-189451;KEGG: 00860+1.3.3.3	"3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent)";"Heme biosynthesis";"Porphyrin and chlorophyll metabolism"
Medex_00074624-RA	1	Reactome: R-HSA-6811438	"Intra-Golgi traffic"
Medex_00001744-RA	1	Reactome: R-HSA-6803157	"Antimicrobial peptides"
Medex_00079908-RA	1	Reactome: R-HSA-1237044	"Erythrocytes take up carbon dioxide and release oxygen"
Medex_00022463-RA	4	Reactome: R-HSA-6781823;Reactome: R-HSA-6782135;Reactome: R-HSA-6781827;Reactome: R-HSA-6782210	"Formation of TC-NER Pre-Incision Complex";"Dual incision in TC-NER";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Gap-filling DNA repair synthesis and ligation in TC-NER"
Medex_00014514-RA	2	Reactome: R-HSA-390471;Reactome: R-HSA-1660662	"Association of TriC/CCT with target proteins during biosynthesis";"Glycosphingolipid metabolism"
Medex_00079352-RA	1	Reactome: R-HSA-6799198	"Complex I biogenesis"
Medex_00103649-RA	5	MetaCyc: PWY-6855;MetaCyc: PWY-7822;MetaCyc: PWY-6902;Reactome: R-HSA-189085;KEGG: 00520+3.2.1.14	"Chitin degradation I (archaea)";"Chitin degradation III (Serratia)";"Chitin degradation II (Vibrio)";"Digestion of dietary carbohydrate";"Amino sugar and nucleotide sugar metabolism"
Medex_00008778-RA	3	Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-212436	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"Generic Transcription Pathway"
Medex_00039865-RA	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
Medex_00065319-RA	1	Reactome: R-HSA-110320	"Translesion Synthesis by POLH"
Medex_00005396-RA	2	Reactome: R-HSA-3214858;Reactome: R-HSA-8939243	"RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"
Medex_00051432-RA	26	Reactome: R-HSA-6811436;Reactome: R-HSA-9609690;Reactome: R-HSA-8955332;Reactome: R-HSA-190840;Reactome: R-HSA-190861;Reactome: R-HSA-6807878;Reactome: R-HSA-437239;Reactome: R-HSA-9619483;Reactome: R-HSA-2132295;Reactome: R-HSA-5626467;Reactome: R-HSA-9609736;Reactome: R-HSA-983189;Reactome: R-HSA-8852276;Reactome: R-HSA-389960;Reactome: R-HSA-1445148;Reactome: R-HSA-5663220;Reactome: R-HSA-3371497;Reactome: R-HSA-2500257;Reactome: R-HSA-380320;Reactome: R-HSA-5617833;Reactome: R-HSA-9646399;Reactome: R-HSA-2467813;Reactome: R-HSA-389977;Reactome: R-HSA-68877;Reactome: R-HSA-9648025;Reactome: R-HSA-6811434	"COPI-independent Golgi-to-ER retrograde traffic";"HCMV Early Events";"Carboxyterminal post-translational modifications of tubulin";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Gap junction assembly";"COPI-mediated anterograde transport";"Recycling pathway of L1";"Activation of AMPK downstream of NMDARs";"MHC class II antigen presentation";"RHO GTPases activate IQGAPs";"Assembly and cell surface presentation of NMDA receptors";"Kinesins";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Formation of tubulin folding intermediates by CCT/TriC";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"RHO GTPases Activate Formins";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Resolution of Sister Chromatid Cohesion";"Recruitment of NuMA to mitotic centrosomes";"Cilium Assembly";"Aggrephagy";"Separation of Sister Chromatids";"Post-chaperonin tubulin folding pathway";"Mitotic Prometaphase";"EML4 and NUDC in mitotic spindle formation";"COPI-dependent Golgi-to-ER retrograde traffic"
Medex_00012606-RA	1	Reactome: R-HSA-77289	"Mitochondrial Fatty Acid Beta-Oxidation"
Medex_00023524-RA	3	Reactome: R-HSA-6798695;Reactome: R-HSA-6811434;Reactome: R-HSA-6807878	"Neutrophil degranulation";"COPI-dependent Golgi-to-ER retrograde traffic";"COPI-mediated anterograde transport"
Medex_00032212-RA	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
Medex_00011260-RA	2	KEGG: 00500+3.2.1.28;Reactome: R-HSA-189085	"Starch and sucrose metabolism";"Digestion of dietary carbohydrate"
Medex_00102606-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Medex_00045922-RA	13	Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-156902;Reactome: R-HSA-9633012;Reactome: R-HSA-1799339;Reactome: R-HSA-192823;Reactome: R-HSA-975957;Reactome: R-HSA-6791226;Reactome: R-HSA-2408557;Reactome: R-HSA-72689;Reactome: R-HSA-72764;Reactome: R-HSA-975956;Reactome: R-HSA-72706	"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Peptide chain elongation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"SRP-dependent cotranslational protein targeting to membrane";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"Selenocysteine synthesis";"Formation of a pool of free 40S subunits";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit"
Medex_00096536-RA	3	Reactome: R-HSA-8939902;Reactome: R-HSA-8878166;Reactome: R-HSA-6785807	"Regulation of RUNX2 expression and activity";"Transcriptional regulation by RUNX2";"Interleukin-4 and Interleukin-13 signaling"
Medex_00010149-RA	9	Reactome: R-HSA-166208;Reactome: R-HSA-9639288;Reactome: R-HSA-1632852;Reactome: R-HSA-165159;Reactome: R-HSA-380972;Reactome: R-HSA-8943724;Reactome: R-HSA-6798695;Reactome: R-HSA-5628897;Reactome: R-HSA-5674135	"mTORC1-mediated signalling";"Amino acids regulate mTORC1";"Macroautophagy";"mTOR signalling";"Energy dependent regulation of mTOR by LKB1-AMPK";"Regulation of PTEN gene transcription";"Neutrophil degranulation";"TP53 Regulates Metabolic Genes";"MAP2K and MAPK activation"
Medex_00060037-RA	4	KEGG: 00010+1.2.1.59;Reactome: R-HSA-70171;Reactome: R-HSA-70263;KEGG: 00710+1.2.1.59	"Glycolysis / Gluconeogenesis";"Glycolysis";"Gluconeogenesis";"Carbon fixation in photosynthetic organisms"
Medex_00019060-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Medex_00014179-RA	1	Reactome: R-HSA-880009	"Interconversion of 2-oxoglutarate and 2-hydroxyglutarate"
Medex_00102219-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00043783-RA	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
Medex_00026306-RA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
Medex_00091029-RA	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276	"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination"
Medex_00082911-RA	1	Reactome: R-HSA-6799198	"Complex I biogenesis"
Medex_00037061-RA	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
Medex_00005992-RA	13	KEGG: 00770+3.6.1.9;KEGG: 00500+3.6.1.9;MetaCyc: PWY-7206;KEGG: 00230+3.6.1.66;KEGG: 00230+3.6.1.9;KEGG: 00240+3.6.1.9;MetaCyc: PWY-7821;KEGG: 00740+3.6.1.9;MetaCyc: PWY-6545;Reactome: R-HSA-74259;KEGG: 00760+3.6.1.9;MetaCyc: PWY-7184;MetaCyc: PWY-7187	"Pantothenate and CoA biosynthesis";"Starch and sucrose metabolism";"Pyrimidine deoxyribonucleotides dephosphorylation";"Purine metabolism";"Purine metabolism";"Pyrimidine metabolism";"Tunicamycin biosynthesis";"Riboflavin metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Purine catabolism";"Nicotinate and nicotinamide metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Pyrimidine deoxyribonucleotides de novo biosynthesis II"
Medex_00035712-RA	7	Reactome: R-HSA-110328;Reactome: R-HSA-110331;Reactome: R-HSA-1221632;Reactome: R-HSA-2559586;Reactome: R-HSA-110329;Reactome: R-HSA-110330;Reactome: R-HSA-171306	"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"Cleavage of the damaged purine";"Meiotic synapsis";"DNA Damage/Telomere Stress Induced Senescence";"Cleavage of the damaged pyrimidine";"Recognition and association of DNA glycosylase with site containing an affected purine";"Packaging Of Telomere Ends"
Medex_00063593-RA	1	KEGG: 00230+4.6.1.2	"Purine metabolism"
Medex_00006860-RA	5	Reactome: R-HSA-163765;Reactome: R-HSA-2426168;Reactome: R-HSA-75105;Reactome: R-HSA-9029558;Reactome: R-HSA-199220	"ChREBP activates metabolic gene expression";"Activation of gene expression by SREBF (SREBP)";"Fatty acyl-CoA biosynthesis";"NR1H2 & NR1H3 regulate gene expression linked to lipogenesis";"Vitamin B5 (pantothenate) metabolism"
Medex_00032036-RA	4	Reactome: R-HSA-2122947;Reactome: R-HSA-2644606;Reactome: R-HSA-2894862;Reactome: R-HSA-350054	"NOTCH1 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Notch-HLH transcription pathway"
Medex_00011998-RA	2	MetaCyc: PWY-6981;KEGG: 00520+2.4.1.16	"Chitin biosynthesis";"Amino sugar and nucleotide sugar metabolism"
Medex_00027883-RA	1	Reactome: R-HSA-420029	"Tight junction interactions"
Medex_00032430-RA	5	KEGG: 00270+6.3.2.3;Reactome: R-HSA-174403;Reactome: R-HSA-5579006;MetaCyc: PWY-8043;KEGG: 00480+6.3.2.3	"Cysteine and methionine metabolism";"Glutathione synthesis and recycling";"Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)";"Ophthalmate biosynthesis";"Glutathione metabolism"
Medex_00075778-RA	1	Reactome: R-HSA-1632852	"Macroautophagy"
Medex_00034889-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00011981-RA	5	KEGG: 00561+3.2.1.22;MetaCyc: PWY-6527;KEGG: 00600+3.2.1.22;KEGG: 00603+3.2.1.22;KEGG: 00052+3.2.1.22	"Glycerolipid metabolism";"Stachyose degradation";"Sphingolipid metabolism";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Galactose metabolism"
Medex_00022968-RA	1	Reactome: R-HSA-216083	"Integrin cell surface interactions"
Medex_00006001-RA	1	Reactome: R-HSA-83936	"Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"
Medex_00057939-RA	3	Reactome: R-HSA-1660516;Reactome: R-HSA-1660514;Reactome: R-HSA-1660517	"Synthesis of PIPs at the early endosome membrane";"Synthesis of PIPs at the Golgi membrane";"Synthesis of PIPs at the late endosome membrane"
Medex_00022559-RA	1	Reactome: R-HSA-1632852	"Macroautophagy"
Medex_00091148-RA	13	Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-9633012;Reactome: R-HSA-156902;Reactome: R-HSA-1799339;Reactome: R-HSA-192823;Reactome: R-HSA-975957;Reactome: R-HSA-6791226;Reactome: R-HSA-2408557;Reactome: R-HSA-72764;Reactome: R-HSA-72689;Reactome: R-HSA-975956;Reactome: R-HSA-72706	"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Peptide chain elongation";"SRP-dependent cotranslational protein targeting to membrane";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"Selenocysteine synthesis";"Eukaryotic Translation Termination";"Formation of a pool of free 40S subunits";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit"
Medex_00033805-RA	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
Medex_00004911-RA	2	Reactome: R-HSA-379716;KEGG: 00970+6.1.1.20	"Cytosolic tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis"
Medex_00083257-RA	2	Reactome: R-HSA-416476;Reactome: R-HSA-388479	"G alpha (q) signalling events";"Vasopressin-like receptors"
Medex_00084434-RA	2	Reactome: R-HSA-2682334;Reactome: R-HSA-3928665	"EPH-Ephrin signaling";"EPH-ephrin mediated repulsion of cells"
Medex_00054514-RA	2	Reactome: R-HSA-6811434;Reactome: R-HSA-6807878	"COPI-dependent Golgi-to-ER retrograde traffic";"COPI-mediated anterograde transport"
Medex_00039686-RA	1	Reactome: R-HSA-83936	"Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"
Medex_00042057-RA	1	Reactome: R-HSA-5676934	"Protein repair"
Medex_00031923-RA	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
Medex_00005253-RA	1	Reactome: R-HSA-6811440	"Retrograde transport at the Trans-Golgi-Network"
Medex_00044744-RA	83	Reactome: R-HSA-179812;Reactome: R-HSA-5654732;Reactome: R-HSA-8853659;Reactome: R-HSA-5654706;Reactome: R-HSA-2219530;Reactome: R-HSA-9027284;Reactome: R-HSA-5654720;Reactome: R-HSA-5654712;Reactome: R-HSA-1250347;Reactome: R-HSA-5654688;Reactome: R-HSA-1433559;Reactome: R-HSA-8875360;Reactome: R-HSA-983695;Reactome: R-HSA-2424491;Reactome: R-HSA-354194;Reactome: R-HSA-8875656;Reactome: R-HSA-112412;Reactome: R-HSA-9645135;Reactome: R-HSA-391160;Reactome: R-HSA-1963640;Reactome: R-HSA-180292;Reactome: R-HSA-5654689;Reactome: R-HSA-9028335;Reactome: R-HSA-5655302;Reactome: R-HSA-8851805;Reactome: R-HSA-74749;Reactome: R-HSA-1433557;Reactome: R-HSA-180336;Reactome: R-HSA-6807004;Reactome: R-HSA-2871796;Reactome: R-HSA-912526;Reactome: R-HSA-8856825;Reactome: R-HSA-8856828;Reactome: R-HSA-186763;Reactome: R-HSA-5654699;Reactome: R-HSA-8865999;Reactome: R-HSA-8851907;Reactome: R-HSA-109704;Reactome: R-HSA-1257604;Reactome: R-HSA-2730905;Reactome: R-HSA-5637810;Reactome: R-HSA-9026519;Reactome: R-HSA-8853338;Reactome: R-HSA-167044;Reactome: R-HSA-375165;Reactome: R-HSA-5673001;Reactome: R-HSA-2179392;Reactome: R-HSA-8875555;Reactome: R-HSA-1236382;Reactome: R-HSA-5654704;Reactome: R-HSA-1295596;Reactome: R-HSA-2428933;Reactome: R-HSA-9034864;Reactome: R-HSA-5654733;Reactome: R-HSA-1963642;Reactome: R-HSA-512988;Reactome: R-HSA-5654719;Reactome: R-HSA-5654726;Reactome: R-HSA-5663213;Reactome: R-HSA-9607240;Reactome: R-HSA-9664565;Reactome: R-HSA-5654693;Reactome: R-HSA-2029482;Reactome: R-HSA-210993;Reactome: R-HSA-1250196;Reactome: R-HSA-9634285;Reactome: R-HSA-182971;Reactome: R-HSA-9028731;Reactome: R-HSA-912631;Reactome: R-HSA-389359;Reactome: R-HSA-5654710;Reactome: R-HSA-6811558;Reactome: R-HSA-8983432;Reactome: R-HSA-388841;Reactome: R-HSA-74751;Reactome: R-HSA-8853334;Reactome: R-HSA-5655291;Reactome: R-HSA-5654727;Reactome: R-HSA-2871809;Reactome: R-HSA-1839117;Reactome: R-HSA-5654700;Reactome: R-HSA-5655253;Reactome: R-HSA-5654695	"GRB2 events in EGFR signaling";"Negative regulation of FGFR3 signaling";"RET signaling";"FRS-mediated FGFR3 signaling";"Constitutive Signaling by Aberrant PI3K in Cancer";"Erythropoietin activates RAS";"PI-3K cascade:FGFR4";"FRS-mediated FGFR4 signaling";"SHC1 events in ERBB4 signaling";"SHC-mediated cascade:FGFR1";"Regulation of KIT signaling";"InlB-mediated entry of Listeria monocytogenes into host cell";"Antigen activates B Cell Receptor (BCR) leading to generation of second messengers";"DAP12 signaling";"GRB2:SOS provides linkage to MAPK signaling for Integrins";"MET receptor recycling";"SOS-mediated signalling";"STAT5 Activation";"Signal regulatory protein family interactions";"GRB2 events in ERBB2 signaling";"GAB1 signalosome";"PI-3K cascade:FGFR1";"Activated NTRK2 signals through PI3K";"Signaling by FGFR1 in disease";"MET activates RAS signaling";"Signal attenuation";"Signaling by SCF-KIT";"SHC1 events in EGFR signaling";"Negative regulation of MET activity";"FCERI mediated MAPK activation";"Interleukin receptor SHC signaling";"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis";"Downstream signal transduction";"SHC-mediated cascade:FGFR2";"MET activates PTPN11";"MET activates PI3K/AKT signaling";"PI3K Cascade";"PIP3 activates AKT signaling";"Role of LAT2/NTAL/LAB on calcium mobilization";"Constitutive Signaling by EGFRvIII";"Activated NTRK2 signals through RAS";"Signaling by FGFR3 point mutants in cancer";"Signalling to RAS";"NCAM signaling for neurite out-growth";"RAF/MAP kinase cascade";"EGFR Transactivation by Gastrin";"MET activates RAP1 and RAC1";"Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants";"SHC-mediated cascade:FGFR3";"Spry regulation of FGF signaling";"SHC-related events triggered by IGF1R";"Activated NTRK3 signals through RAS";"Negative regulation of FGFR4 signaling";"PI3K events in ERBB2 signaling";"Interleukin-3, Interleukin-5 and GM-CSF signaling";"SHC-mediated cascade:FGFR4";"Negative regulation of FGFR1 signaling";"RHO GTPases Activate WASPs and WAVEs";"FLT3 Signaling";"Signaling by ERBB2 KD Mutants";"FRS-mediated FGFR1 signaling";"Regulation of actin dynamics for phagocytic cup formation";"Tie2 Signaling";"SHC1 events in ERBB2 signaling";"Constitutive Signaling by Overexpressed ERBB2";"EGFR downregulation";"Activated NTRK2 signals through FRS2 and FRS3";"Regulation of signaling by CBL";"CD28 dependent Vav1 pathway";"PI-3K cascade:FGFR3";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"Interleukin-15 signaling";"Costimulation by the CD28 family";"Insulin receptor signalling cascade";"Signaling by FGFR3 fusions in cancer";"Signaling by FGFR4 in disease";"Negative regulation of FGFR2 signaling";"FCERI mediated Ca+2 mobilization";"Signaling by cytosolic FGFR1 fusion mutants";"FRS-mediated FGFR2 signaling";"Signaling by FGFR2 in disease";"PI-3K cascade:FGFR2"
Medex_00093325-RA	3	Reactome: R-HSA-1855167;KEGG: 04070+2.7.4.24+2.7.4.21;MetaCyc: PWY-6369	"Synthesis of pyrophosphates in the cytosol";"Phosphatidylinositol signaling system";"Inositol diphosphates biosynthesis"
Medex_00014158-RA	4	Reactome: R-HSA-69656;Reactome: R-HSA-8953750;Reactome: R-HSA-69202;Reactome: R-HSA-1362277	"Cyclin A:Cdk2-associated events at S phase entry";"Transcriptional Regulation by E2F6";"Cyclin E associated events during G1/S transition";"Transcription of E2F targets under negative control by DREAM complex"
Medex_00062204-RA	1	Reactome: R-HSA-162791	"Attachment of GPI anchor to uPAR"
Medex_00061985-RA	2	Reactome: R-HSA-429947;Reactome: R-HSA-6804115	"Deadenylation of mRNA";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"
Medex_00011285-RA	1	Reactome: R-HSA-5625900	"RHO GTPases activate CIT"
Medex_00003897-RA	2	Reactome: R-HSA-379726;KEGG: 00970+6.1.1.5	"Mitochondrial tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis"
Medex_00020600-RA	4	Reactome: R-HSA-1660662;Reactome: R-HSA-4085001;KEGG: 00600+3.2.1.18;KEGG: 00511+3.2.1.18	"Glycosphingolipid metabolism";"Sialic acid metabolism";"Sphingolipid metabolism";"Other glycan degradation"
Medex_00032918-RA	56	Reactome: R-HSA-195253;Reactome: R-HSA-8939902;Reactome: R-HSA-75815;Reactome: R-HSA-5687128;Reactome: R-HSA-5689603;Reactome: R-HSA-5668541;Reactome: R-HSA-4608870;Reactome: R-HSA-5610785;Reactome: R-HSA-5689880;Reactome: R-HSA-349425;Reactome: R-HSA-1236978;Reactome: R-HSA-180534;Reactome: R-HSA-5632684;Reactome: R-HSA-174178;Reactome: R-HSA-5607761;Reactome: R-HSA-8852276;Reactome: R-HSA-5610780;Reactome: R-HSA-983168;Reactome: R-HSA-202424;Reactome: R-HSA-5658442;Reactome: R-HSA-5358346;Reactome: R-HSA-8941858;Reactome: R-HSA-9020702;Reactome: R-HSA-180585;Reactome: R-HSA-450408;Reactome: R-HSA-4641258;Reactome: R-HSA-2467813;Reactome: R-HSA-9010553;Reactome: R-HSA-68949;Reactome: R-HSA-382556;Reactome: R-HSA-8939236;Reactome: R-HSA-211733;Reactome: R-HSA-174113;Reactome: R-HSA-4641257;Reactome: R-HSA-350562;Reactome: R-HSA-5678895;Reactome: R-HSA-69481;Reactome: R-HSA-68827;Reactome: R-HSA-8948751;Reactome: R-HSA-9604323;Reactome: R-HSA-1234176;Reactome: R-HSA-5362768;Reactome: R-HSA-69601;Reactome: R-HSA-69017;Reactome: R-HSA-5676590;Reactome: R-HSA-5607764;Reactome: R-HSA-174184;Reactome: R-HSA-1169091;Reactome: R-HSA-174154;Reactome: R-HSA-8951664;Reactome: R-HSA-2871837;Reactome: R-HSA-187577;Reactome: R-HSA-174084;Reactome: R-HSA-1236974;Reactome: R-HSA-8854050;Reactome: R-HSA-5610783	"Degradation of beta-catenin by the destruction complex";"Regulation of RUNX2 expression and activity";"Ubiquitin-dependent degradation of Cyclin D";"MAPK6/MAPK4 signaling";"UCH proteinases";"TNFR2 non-canonical NF-kB pathway";"Asymmetric localization of PCP proteins";"GLI3 is processed to GLI3R by the proteasome";"Ub-specific processing proteases";"Autodegradation of the E3 ubiquitin ligase COP1";"Cross-presentation of soluble exogenous antigens (endosomes)";"Vpu mediated degradation of CD4";"Hedgehog 'on' state";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Dectin-1 mediated noncanonical NF-kB signaling";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Degradation of GLI1 by the proteasome";"Antigen processing: Ubiquitination & Proteasome degradation";"Downstream TCR signaling";"Regulation of RAS by GAPs";"Hedgehog ligand biogenesis";"Regulation of RUNX3 expression and activity";"Interleukin-1 signaling";"Vif-mediated degradation of APOBEC3G";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Degradation of DVL";"Separation of Sister Chromatids";"Regulation of expression of SLITs and ROBOs";"Orc1 removal from chromatin";"ABC-family proteins mediated transport";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"SCF-beta-TrCP mediated degradation of Emi1";"Degradation of AXIN";"Regulation of ornithine decarboxylase (ODC)";"Defective CFTR causes cystic fibrosis";"G2/M Checkpoints";"CDT1 association with the CDC6:ORC:origin complex";"Regulation of PTEN stability and activity";"Negative regulation of NOTCH4 signaling";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"CDK-mediated phosphorylation and removal of Cdc6";"NIK-->noncanonical NF-kB signaling";"CLEC7A (Dectin-1) signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Activation of NF-kappaB in B cells";"APC/C:Cdc20 mediated degradation of Securin";"Neddylation";"FCERI mediated NF-kB activation";"SCF(Skp2)-mediated degradation of p27/p21";"Autodegradation of Cdh1 by Cdh1:APC/C";"ER-Phagosome pathway";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Degradation of GLI2 by the proteasome"
Medex_00016260-RA	6	Reactome: R-HSA-159236;Reactome: R-HSA-9010553;Reactome: R-HSA-73856;Reactome: R-HSA-975957;Reactome: R-HSA-72187;Reactome: R-HSA-72163	"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Regulation of expression of SLITs and ROBOs";"RNA Polymerase II Transcription Termination";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"mRNA 3'-end processing";"mRNA Splicing - Major Pathway"
Medex_00029819-RA	3	Reactome: R-HSA-983189;Reactome: R-HSA-390471;Reactome: R-HSA-6811434	"Kinesins";"Association of TriC/CCT with target proteins during biosynthesis";"COPI-dependent Golgi-to-ER retrograde traffic"
Medex_00033007-RA	4	KEGG: 00260+4.2.1.22;MetaCyc: PWY-801;KEGG: 00270+4.2.1.22;Reactome: R-HSA-1614603	"Glycine, serine and threonine metabolism";"Homocysteine and cysteine interconversion";"Cysteine and methionine metabolism";"Cysteine formation from homocysteine"
Medex_00049511-RA	24	Reactome: R-HSA-3371497;Reactome: R-HSA-380320;Reactome: R-HSA-2500257;Reactome: R-HSA-1445148;Reactome: R-HSA-5663220;Reactome: R-HSA-9648025;Reactome: R-HSA-6811434;Reactome: R-HSA-68877;Reactome: R-HSA-9646399;Reactome: R-HSA-5617833;Reactome: R-HSA-2467813;Reactome: R-HSA-2132295;Reactome: R-HSA-5626467;Reactome: R-HSA-8955332;Reactome: R-HSA-6811436;Reactome: R-HSA-9609690;Reactome: R-HSA-190840;Reactome: R-HSA-6807878;Reactome: R-HSA-437239;Reactome: R-HSA-9619483;Reactome: R-HSA-190861;Reactome: R-HSA-8852276;Reactome: R-HSA-9609736;Reactome: R-HSA-983189	"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Recruitment of NuMA to mitotic centrosomes";"Resolution of Sister Chromatid Cohesion";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"RHO GTPases Activate Formins";"EML4 and NUDC in mitotic spindle formation";"COPI-dependent Golgi-to-ER retrograde traffic";"Mitotic Prometaphase";"Aggrephagy";"Cilium Assembly";"Separation of Sister Chromatids";"MHC class II antigen presentation";"RHO GTPases activate IQGAPs";"Carboxyterminal post-translational modifications of tubulin";"COPI-independent Golgi-to-ER retrograde traffic";"HCMV Early Events";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"COPI-mediated anterograde transport";"Recycling pathway of L1";"Activation of AMPK downstream of NMDARs";"Gap junction assembly";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Assembly and cell surface presentation of NMDA receptors";"Kinesins"
Medex_00072959-RA	1	KEGG: 00760+2.3.1.286	"Nicotinate and nicotinamide metabolism"
Medex_00013826-RA	3	KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16	"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
Medex_00097138-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Medex_00021733-RA	7	MetaCyc: PWY-7511;Reactome: R-HSA-2979096;Reactome: R-HSA-2122948;Reactome: R-HSA-9013507;Reactome: R-HSA-2644606;Reactome: R-HSA-2894862;Reactome: R-HSA-2691232	"Protein ubiquitination";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Activated NOTCH1 Transmits Signal to the Nucleus";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Constitutive Signaling by NOTCH1 HD Domain Mutants"
Medex_00064419-RA	7	Reactome: R-HSA-5620912;Reactome: R-HSA-380284;Reactome: R-HSA-380259;Reactome: R-HSA-2565942;Reactome: R-HSA-8854518;Reactome: R-HSA-380270;Reactome: R-HSA-380320	"Anchoring of the basal body to the plasma membrane";"Loss of proteins required for interphase microtubule organization from the centrosome";"Loss of Nlp from mitotic centrosomes";"Regulation of PLK1 Activity at G2/M Transition";"AURKA Activation by TPX2";"Recruitment of mitotic centrosome proteins and complexes";"Recruitment of NuMA to mitotic centrosomes"
Medex_00098743-RA	2	Reactome: R-HSA-2151201;Reactome: R-HSA-8964539	"Transcriptional activation of mitochondrial biogenesis";"Glutamate and glutamine metabolism"
Medex_00017081-RA	6	MetaCyc: PWY-5530;KEGG: 00030+3.1.1.17;KEGG: 00053+3.1.1.17;KEGG: 00930+3.1.1.17;MetaCyc: PWY-7165;MetaCyc: PWY-2221	"Sorbitol biosynthesis II";"Pentose phosphate pathway";"Ascorbate and aldarate metabolism";"Caprolactam degradation";"L-ascorbate biosynthesis VI (engineered pathway)";"Entner-Doudoroff pathway III (semi-phosphorylative)"
Medex_00060717-RA	1	Reactome: R-HSA-1474228	"Degradation of the extracellular matrix"
Medex_00068590-RA	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
Medex_00081994-RA	2	Reactome: R-HSA-72165;Reactome: R-HSA-72163	"mRNA Splicing - Minor Pathway";"mRNA Splicing - Major Pathway"
Medex_00086772-RA	2	Reactome: R-HSA-983168;Reactome: R-HSA-8951664	"Antigen processing: Ubiquitination & Proteasome degradation";"Neddylation"
Medex_00034058-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00024229-RA	2	Reactome: R-HSA-5576892;Reactome: R-HSA-445095	"Phase 0 - rapid depolarisation";"Interaction between L1 and Ankyrins"
Medex_00014600-RA	6	KEGG: 00052+3.2.1.23;KEGG: 00531+3.2.1.23;KEGG: 00604+3.2.1.23;MetaCyc: PWY-6807;KEGG: 00511+3.2.1.23;KEGG: 00600+3.2.1.23	"Galactose metabolism";"Glycosaminoglycan degradation";"Glycosphingolipid biosynthesis - ganglio series";"Xyloglucan degradation II (exoglucanase)";"Other glycan degradation";"Sphingolipid metabolism"
Medex_00007531-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Medex_00013753-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Medex_00058947-RA	14	MetaCyc: PWY-6433;MetaCyc: PWY-7036;MetaCyc: PWY-7619;MetaCyc: PWY-7602;MetaCyc: PWY-7035;Reactome: R-HSA-75876;MetaCyc: PWY-5972;MetaCyc: PWY-7724;MetaCyc: PWY-7601;KEGG: 00062+2.3.1.199;MetaCyc: PWY-6598;MetaCyc: PWY-7725;MetaCyc: PWY-8041;MetaCyc: PWY-5080	"Hydroxylated fatty acid biosynthesis (plants)";"Very long chain fatty acid biosynthesis II";"Juniperonate biosynthesis";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"(9Z)-tricosene biosynthesis";"Synthesis of very long-chain fatty acyl-CoAs";"Stearate biosynthesis I (animals)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Fatty acid elongation";"Sciadonate biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Ultra-long-chain fatty acid biosynthesis";"Very long chain fatty acid biosynthesis I"
Medex_00067948-RA	1	KEGG: 00760+2.3.1.286	"Nicotinate and nicotinamide metabolism"
Medex_00029225-RA	5	KEGG: 00720+4.2.1.3;Reactome: R-HSA-917937;KEGG: 00020+4.2.1.3;KEGG: 00290+4.2.1.33;KEGG: 00630+4.2.1.3	"Carbon fixation pathways in prokaryotes";"Iron uptake and transport";"Citrate cycle (TCA cycle)";"Valine, leucine and isoleucine biosynthesis";"Glyoxylate and dicarboxylate metabolism"
Medex_00015501-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00007413-RA	1	Reactome: R-HSA-6787450	"tRNA modification in the mitochondrion"
Medex_00057595-RA	2	Reactome: R-HSA-6804115;Reactome: R-HSA-429947	"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Deadenylation of mRNA"
Medex_00032830-RA	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
Medex_00037184-RA	5	KEGG: 00310+1.2.4.2;MetaCyc: PWY-5084;Reactome: R-HSA-389661;KEGG: 00380+1.2.4.2;KEGG: 00020+1.2.4.2	"Lysine degradation";"2-oxoglutarate decarboxylation to succinyl-CoA";"Glyoxylate metabolism and glycine degradation";"Tryptophan metabolism";"Citrate cycle (TCA cycle)"
Medex_00065442-RA	8	KEGG: 00010+2.7.1.1;KEGG: 00524+2.7.1.1;KEGG: 00051+2.7.1.1;KEGG: 00520+2.7.1.1;KEGG: 00500+2.7.1.1;KEGG: 00521+2.7.1.1;KEGG: 00052+2.7.1.1;Reactome: R-HSA-70171	"Glycolysis / Gluconeogenesis";"Neomycin, kanamycin and gentamicin biosynthesis";"Fructose and mannose metabolism";"Amino sugar and nucleotide sugar metabolism";"Starch and sucrose metabolism";"Streptomycin biosynthesis";"Galactose metabolism";"Glycolysis"
Medex_00066754-RA	56	Reactome: R-HSA-5676590;Reactome: R-HSA-1234176;Reactome: R-HSA-69601;Reactome: R-HSA-69017;Reactome: R-HSA-5362768;Reactome: R-HSA-9604323;Reactome: R-HSA-68827;Reactome: R-HSA-8948751;Reactome: R-HSA-69481;Reactome: R-HSA-5678895;Reactome: R-HSA-350562;Reactome: R-HSA-4641257;Reactome: R-HSA-174113;Reactome: R-HSA-2871837;Reactome: R-HSA-8951664;Reactome: R-HSA-174154;Reactome: R-HSA-1169091;Reactome: R-HSA-5607764;Reactome: R-HSA-174184;Reactome: R-HSA-174084;Reactome: R-HSA-187577;Reactome: R-HSA-5610783;Reactome: R-HSA-8854050;Reactome: R-HSA-1236974;Reactome: R-HSA-5689880;Reactome: R-HSA-5610785;Reactome: R-HSA-4608870;Reactome: R-HSA-5689603;Reactome: R-HSA-5687128;Reactome: R-HSA-5668541;Reactome: R-HSA-75815;Reactome: R-HSA-8939902;Reactome: R-HSA-195253;Reactome: R-HSA-5610780;Reactome: R-HSA-8852276;Reactome: R-HSA-5607761;Reactome: R-HSA-174178;Reactome: R-HSA-5632684;Reactome: R-HSA-180534;Reactome: R-HSA-1236978;Reactome: R-HSA-349425;Reactome: R-HSA-9020702;Reactome: R-HSA-5358346;Reactome: R-HSA-8941858;Reactome: R-HSA-5658442;Reactome: R-HSA-202424;Reactome: R-HSA-983168;Reactome: R-HSA-8939236;Reactome: R-HSA-68949;Reactome: R-HSA-382556;Reactome: R-HSA-211733;Reactome: R-HSA-9010553;Reactome: R-HSA-2467813;Reactome: R-HSA-4641258;Reactome: R-HSA-450408;Reactome: R-HSA-180585	"NIK-->noncanonical NF-kB signaling";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"CDK-mediated phosphorylation and removal of Cdc6";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Negative regulation of NOTCH4 signaling";"CDT1 association with the CDC6:ORC:origin complex";"Regulation of PTEN stability and activity";"G2/M Checkpoints";"Defective CFTR causes cystic fibrosis";"Regulation of ornithine decarboxylase (ODC)";"Degradation of AXIN";"SCF-beta-TrCP mediated degradation of Emi1";"FCERI mediated NF-kB activation";"Neddylation";"APC/C:Cdc20 mediated degradation of Securin";"Activation of NF-kappaB in B cells";"CLEC7A (Dectin-1) signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Autodegradation of Cdh1 by Cdh1:APC/C";"SCF(Skp2)-mediated degradation of p27/p21";"Degradation of GLI2 by the proteasome";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"ER-Phagosome pathway";"Ub-specific processing proteases";"GLI3 is processed to GLI3R by the proteasome";"Asymmetric localization of PCP proteins";"UCH proteinases";"MAPK6/MAPK4 signaling";"TNFR2 non-canonical NF-kB pathway";"Ubiquitin-dependent degradation of Cyclin D";"Regulation of RUNX2 expression and activity";"Degradation of beta-catenin by the destruction complex";"Degradation of GLI1 by the proteasome";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Dectin-1 mediated noncanonical NF-kB signaling";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Hedgehog 'on' state";"Vpu mediated degradation of CD4";"Cross-presentation of soluble exogenous antigens (endosomes)";"Autodegradation of the E3 ubiquitin ligase COP1";"Interleukin-1 signaling";"Hedgehog ligand biogenesis";"Regulation of RUNX3 expression and activity";"Regulation of RAS by GAPs";"Downstream TCR signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Orc1 removal from chromatin";"ABC-family proteins mediated transport";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Regulation of expression of SLITs and ROBOs";"Separation of Sister Chromatids";"Degradation of DVL";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Vif-mediated degradation of APOBEC3G"
Medex_00033786-RA	3	Reactome: R-HSA-212436;Reactome: R-HSA-1989781;Reactome: R-HSA-381340	"Generic Transcription Pathway";"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation"
Medex_00083652-RA	18	MetaCyc: PWY-7226;MetaCyc: PWY-7227;MetaCyc: PWY-7198;Reactome: R-HSA-499943;KEGG: 00230+2.7.4.6;MetaCyc: PWY-7220;MetaCyc: PWY-7197;MetaCyc: PWY-7210;KEGG: 00240+2.7.4.6;MetaCyc: PWY-7205;MetaCyc: PWY-7221;KEGG: 00983+2.7.4.6;MetaCyc: PWY-6545;MetaCyc: PWY-7222;MetaCyc: PWY-7187;MetaCyc: PWY-7176;MetaCyc: PWY-7184;MetaCyc: PWY-7224	"Guanosine deoxyribonucleotides de novo biosynthesis I";"Adenosine deoxyribonucleotides de novo biosynthesis";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Interconversion of nucleotide di- and triphosphates";"Purine metabolism";"Adenosine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotide phosphorylation";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Pyrimidine metabolism";"CMP phosphorylation";"Guanosine ribonucleotides de novo biosynthesis";"Drug metabolism - other enzymes";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Guanosine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotides de novo biosynthesis II";"UTP and CTP de novo biosynthesis";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Purine deoxyribonucleosides salvage"
Medex_00103206-RA	4	Reactome: R-HSA-422085;Reactome: R-HSA-381771;Reactome: R-HSA-1799339;Reactome: R-HSA-400511	"Synthesis, secretion, and deacylation of Ghrelin";"Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)";"SRP-dependent cotranslational protein targeting to membrane";"Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)"
Medex_00013421-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00005364-RA	6	KEGG: 00052+3.2.1.23;KEGG: 00531+3.2.1.23;KEGG: 00604+3.2.1.23;MetaCyc: PWY-6807;KEGG: 00511+3.2.1.23;KEGG: 00600+3.2.1.23	"Galactose metabolism";"Glycosaminoglycan degradation";"Glycosphingolipid biosynthesis - ganglio series";"Xyloglucan degradation II (exoglucanase)";"Other glycan degradation";"Sphingolipid metabolism"
Medex_00019001-RA	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
Medex_00082664-RA	5	Reactome: R-HSA-3371497;Reactome: R-HSA-2132295;Reactome: R-HSA-6807878;Reactome: R-HSA-6811436;Reactome: R-HSA-983231	"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"MHC class II antigen presentation";"COPI-mediated anterograde transport";"COPI-independent Golgi-to-ER retrograde traffic";"Factors involved in megakaryocyte development and platelet production"
Medex_00061047-RA	2	Reactome: R-HSA-3371599;Reactome: R-HSA-196780	"Defective HLCS causes multiple carboxylase deficiency";"Biotin transport and metabolism"
Medex_00077271-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Medex_00052952-RA	1	Reactome: R-HSA-209968	"Thyroxine biosynthesis"
Medex_00093168-RA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
Medex_00081943-RA	1	Reactome: R-HSA-163125	"Post-translational modification: synthesis of GPI-anchored proteins"
Medex_00054564-RA	2	Reactome: R-HSA-1268020;MetaCyc: PWY-7533	"Mitochondrial protein import";"Gliotoxin biosynthesis"
Medex_00087940-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00060096-RA	1	Reactome: R-HSA-5658442	"Regulation of RAS by GAPs"
Medex_00030734-RA	1	Reactome: R-HSA-6809371	"Formation of the cornified envelope"
Medex_00002064-RA	1	KEGG: 00480+3.4.11.2	"Glutathione metabolism"
Medex_00100043-RA	5	MetaCyc: PWY-6902;Reactome: R-HSA-189085;MetaCyc: PWY-6855;MetaCyc: PWY-7822;KEGG: 00520+3.2.1.14	"Chitin degradation II (Vibrio)";"Digestion of dietary carbohydrate";"Chitin degradation I (archaea)";"Chitin degradation III (Serratia)";"Amino sugar and nucleotide sugar metabolism"
Medex_00090645-RA	4	KEGG: 00270+2.5.1.6;MetaCyc: PWY-5041;MetaCyc: PWY-5912;Reactome: R-HSA-156581	"Cysteine and methionine metabolism";"S-adenosyl-L-methionine cycle II";"2'-deoxymugineic acid phytosiderophore biosynthesis";"Methylation"
Medex_00019774-RA	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
Medex_00042264-RA	5	Reactome: R-HSA-73772;Reactome: R-HSA-73762;Reactome: R-HSA-73863;Reactome: R-HSA-5250924;Reactome: R-HSA-427413	"RNA Polymerase I Promoter Escape";"RNA Polymerase I Transcription Initiation";"RNA Polymerase I Transcription Termination";"B-WICH complex positively regulates rRNA expression";"NoRC negatively regulates rRNA expression"
Medex_00001787-RA	6	MetaCyc: PWY-7656;MetaCyc: PWY-7782;MetaCyc: PWY-6733;KEGG: 00073+1.2.1.84;Reactome: R-HSA-9640463;MetaCyc: PWY-5884	"Spodoptera littoralis pheromone biosynthesis";"Plasmalogen biosynthesis";"Sporopollenin precursors biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax biosynthesis";"Wax esters biosynthesis I"
Medex_00009508-RA	2	MetaCyc: PWY-6829;Reactome: R-HSA-6782315	"Trna methylation (yeast)";"tRNA modification in the nucleus and cytosol"
Medex_00088471-RA	2	Reactome: R-HSA-8856828;Reactome: R-HSA-8856825	"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis"
Medex_00056587-RA	3	Reactome: R-HSA-159236;Reactome: R-HSA-72187;Reactome: R-HSA-73856	"Transport of Mature mRNA derived from an Intron-Containing Transcript";"mRNA 3'-end processing";"RNA Polymerase II Transcription Termination"
Medex_00083963-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00040960-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00031762-RA	5	KEGG: 00760+2.7.1.23;MetaCyc: PWY-7269;Reactome: R-HSA-196807;MetaCyc: PWY-7268;MetaCyc: PWY-5083	"Nicotinate and nicotinamide metabolism";"NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)";"Nicotinate metabolism";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"NAD/NADH phosphorylation and dephosphorylation"
Medex_00019129-RA	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
Medex_00002755-RA	1	Reactome: R-HSA-6802952	"Signaling by BRAF and RAF fusions"
Medex_00031765-RA	1	Reactome: R-HSA-8951664	"Neddylation"
Medex_00045873-RA	4	Reactome: R-HSA-73817;KEGG: 00230+6.3.4.4;KEGG: 00250+6.3.4.4;MetaCyc: PWY-7219	"Purine ribonucleoside monophosphate biosynthesis";"Purine metabolism";"Alanine, aspartate and glutamate metabolism";"Adenosine ribonucleotides de novo biosynthesis"
Medex_00020397-RA	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
Medex_00034887-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00021951-RA	2	Reactome: R-HSA-418457;Reactome: R-HSA-4086398	"cGMP effects";"Ca2+ pathway"
Medex_00071267-RA	2	MetaCyc: PWY-7511;Reactome: R-HSA-8866654	"Protein ubiquitination";"E3 ubiquitin ligases ubiquitinate target proteins"
Medex_00065885-RA	1	Reactome: R-HSA-3214858	"RMTs methylate histone arginines"
Medex_00026520-RA	1	Reactome: R-HSA-1368108	"BMAL1:CLOCK,NPAS2 activates circadian gene expression"
Medex_00008478-RA	1	Reactome: R-HSA-1296052	"Ca2+ activated K+ channels"
Medex_00075044-RA	1	MetaCyc: PWY-7942	"5-oxo-L-proline metabolism"
Medex_00066635-RA	5	MetaCyc: PWY-6122;MetaCyc: PWY-6277;KEGG: 00230+6.3.3.1;MetaCyc: PWY-6121;Reactome: R-HSA-73817	"5-aminoimidazole ribonucleotide biosynthesis II";"Superpathway of 5-aminoimidazole ribonucleotide biosynthesis";"Purine metabolism";"5-aminoimidazole ribonucleotide biosynthesis I";"Purine ribonucleoside monophosphate biosynthesis"
Medex_00062931-RA	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
Medex_00019372-RA	3	Reactome: R-HSA-674695;Reactome: R-HSA-112382;Reactome: R-HSA-75955	"RNA Polymerase II Pre-transcription Events";"Formation of RNA Pol II elongation complex";"RNA Polymerase II Transcription Elongation"
Medex_00032017-RA	2	Reactome: R-HSA-8949215;Reactome: R-HSA-5689880	"Mitochondrial calcium ion transport";"Ub-specific processing proteases"
Medex_00014505-RA	3	Reactome: R-HSA-1445148;Reactome: R-HSA-264876;Reactome: R-HSA-5620916	"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Insulin processing";"VxPx cargo-targeting to cilium"
Medex_00021188-RA	2	Reactome: R-HSA-1989781;Reactome: R-HSA-381340	"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation"
Medex_00034897-RA	7	KEGG: 04070+3.1.4.11;MetaCyc: PWY-8052;MetaCyc: PWY-6367;KEGG: 00562+3.1.4.11;Reactome: R-HSA-1855204;MetaCyc: PWY-6351;MetaCyc: PWY-7039	"Phosphatidylinositol signaling system";"2-arachidonoylglycerol biosynthesis";"D-myo-inositol-5-phosphate metabolism";"Inositol phosphate metabolism";"Synthesis of IP3 and IP4 in the cytosol";"D-myo-inositol (1,4,5)-trisphosphate biosynthesis";"Phosphatidate metabolism, as a signaling molecule"
Medex_00029383-RA	1	Reactome: R-HSA-426486	"Small interfering RNA (siRNA) biogenesis"
Medex_00045130-RA	3	KEGG: 00730+3.1.3.1;KEGG: 00790+3.1.3.1;MetaCyc: PWY-5491	"Thiamine metabolism";"Folate biosynthesis";"Diethylphosphate degradation"
Medex_00053367-RA	3	Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-212436	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"Generic Transcription Pathway"
Medex_00041466-RA	14	MetaCyc: PWY-7409;MetaCyc: PWY-8051;MetaCyc: PWY-6803;KEGG: 00565+3.1.1.4;Reactome: R-HSA-975634;KEGG: 00590+3.1.1.4;MetaCyc: PWY-7416;MetaCyc: PWY-8053;KEGG: 00591+3.1.1.4;MetaCyc: PWY-7417;KEGG: 00592+3.1.1.4;KEGG: 00564+3.1.1.4+3.1.1.5;Reactome: R-HSA-1482788;MetaCyc: PWY-7783	"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Anandamide biosynthesis I";"Phosphatidylcholine acyl editing";"Ether lipid metabolism";"Retinoid metabolism and transport";"Arachidonic acid metabolism";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Anandamide biosynthesis II";"Linoleic acid metabolism";"Phospholipid remodeling (phosphatidate, yeast)";"alpha-Linolenic acid metabolism";"Glycerophospholipid metabolism";"Acyl chain remodelling of PC";"Plasmalogen degradation"
Medex_00006689-RA	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
Medex_00001765-RA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Medex_00092819-RA	13	Reactome: R-HSA-975957;Reactome: R-HSA-192823;Reactome: R-HSA-1799339;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-156902;Reactome: R-HSA-9633012;Reactome: R-HSA-975956;Reactome: R-HSA-72706;Reactome: R-HSA-72764;Reactome: R-HSA-72689;Reactome: R-HSA-2408557;Reactome: R-HSA-6791226	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Viral mRNA Translation";"SRP-dependent cotranslational protein targeting to membrane";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Peptide chain elongation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Eukaryotic Translation Termination";"Formation of a pool of free 40S subunits";"Selenocysteine synthesis";"Major pathway of rRNA processing in the nucleolus and cytosol"
Medex_00090121-RA	56	Reactome: R-HSA-187577;Reactome: R-HSA-174084;Reactome: R-HSA-5610783;Reactome: R-HSA-1236974;Reactome: R-HSA-8854050;Reactome: R-HSA-350562;Reactome: R-HSA-5678895;Reactome: R-HSA-69481;Reactome: R-HSA-174113;Reactome: R-HSA-4641257;Reactome: R-HSA-1234176;Reactome: R-HSA-5362768;Reactome: R-HSA-69017;Reactome: R-HSA-69601;Reactome: R-HSA-5676590;Reactome: R-HSA-68827;Reactome: R-HSA-8948751;Reactome: R-HSA-9604323;Reactome: R-HSA-1169091;Reactome: R-HSA-174154;Reactome: R-HSA-5607764;Reactome: R-HSA-174184;Reactome: R-HSA-8951664;Reactome: R-HSA-2871837;Reactome: R-HSA-5658442;Reactome: R-HSA-5358346;Reactome: R-HSA-8941858;Reactome: R-HSA-983168;Reactome: R-HSA-202424;Reactome: R-HSA-9020702;Reactome: R-HSA-4641258;Reactome: R-HSA-2467813;Reactome: R-HSA-180585;Reactome: R-HSA-450408;Reactome: R-HSA-9010553;Reactome: R-HSA-68949;Reactome: R-HSA-382556;Reactome: R-HSA-8939236;Reactome: R-HSA-211733;Reactome: R-HSA-8939902;Reactome: R-HSA-75815;Reactome: R-HSA-195253;Reactome: R-HSA-5689880;Reactome: R-HSA-5610785;Reactome: R-HSA-5687128;Reactome: R-HSA-5689603;Reactome: R-HSA-5668541;Reactome: R-HSA-4608870;Reactome: R-HSA-5632684;Reactome: R-HSA-349425;Reactome: R-HSA-1236978;Reactome: R-HSA-180534;Reactome: R-HSA-5607761;Reactome: R-HSA-5610780;Reactome: R-HSA-8852276;Reactome: R-HSA-174178	"SCF(Skp2)-mediated degradation of p27/p21";"Autodegradation of Cdh1 by Cdh1:APC/C";"Degradation of GLI2 by the proteasome";"ER-Phagosome pathway";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Regulation of ornithine decarboxylase (ODC)";"Defective CFTR causes cystic fibrosis";"G2/M Checkpoints";"SCF-beta-TrCP mediated degradation of Emi1";"Degradation of AXIN";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"CDK-mediated phosphorylation and removal of Cdc6";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"NIK-->noncanonical NF-kB signaling";"CDT1 association with the CDC6:ORC:origin complex";"Regulation of PTEN stability and activity";"Negative regulation of NOTCH4 signaling";"Activation of NF-kappaB in B cells";"APC/C:Cdc20 mediated degradation of Securin";"CLEC7A (Dectin-1) signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Neddylation";"FCERI mediated NF-kB activation";"Regulation of RAS by GAPs";"Hedgehog ligand biogenesis";"Regulation of RUNX3 expression and activity";"Antigen processing: Ubiquitination & Proteasome degradation";"Downstream TCR signaling";"Interleukin-1 signaling";"Degradation of DVL";"Separation of Sister Chromatids";"Vif-mediated degradation of APOBEC3G";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Regulation of expression of SLITs and ROBOs";"Orc1 removal from chromatin";"ABC-family proteins mediated transport";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Regulation of RUNX2 expression and activity";"Ubiquitin-dependent degradation of Cyclin D";"Degradation of beta-catenin by the destruction complex";"Ub-specific processing proteases";"GLI3 is processed to GLI3R by the proteasome";"MAPK6/MAPK4 signaling";"UCH proteinases";"TNFR2 non-canonical NF-kB pathway";"Asymmetric localization of PCP proteins";"Hedgehog 'on' state";"Autodegradation of the E3 ubiquitin ligase COP1";"Cross-presentation of soluble exogenous antigens (endosomes)";"Vpu mediated degradation of CD4";"Dectin-1 mediated noncanonical NF-kB signaling";"Degradation of GLI1 by the proteasome";"The role of GTSE1 in G2/M progression after G2 checkpoint";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1"
Medex_00048346-RA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00083679-RA	7	Reactome: R-HSA-201681;Reactome: R-HSA-4641262;Reactome: R-HSA-5368598;Reactome: R-HSA-201688;Reactome: R-HSA-4086400;Reactome: R-HSA-5663220;Reactome: R-HSA-4641258	"TCF dependent signaling in response to WNT";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"Negative regulation of TCF-dependent signaling by DVL-interacting proteins";"WNT mediated activation of DVL";"PCP/CE pathway";"RHO GTPases Activate Formins";"Degradation of DVL"
Medex_00046201-RA	6	MetaCyc: PWY-7039;Reactome: R-HSA-114508;KEGG: 00561+2.7.1.107;KEGG: 04070+2.7.1.107;MetaCyc: PWY-7817;KEGG: 00564+2.7.1.107	"Phosphatidate metabolism, as a signaling molecule";"Effects of PIP2 hydrolysis";"Glycerolipid metabolism";"Phosphatidylinositol signaling system";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Glycerophospholipid metabolism"
Medex_00020793-RA	6	MetaCyc: PWY-7426;MetaCyc: PWY-7920;Reactome: R-HSA-975578;Reactome: R-HSA-4793952;KEGG: 00513+2.4.1.143;KEGG: 00510+2.4.1.143	"Complex N-linked glycan biosynthesis (vertebrates)";"Complex N-linked glycan biosynthesis (plants)";"Reactions specific to the complex N-glycan synthesis pathway";"Defective MGAT2 causes MGAT2-CDG (CDG-2a)";"Various types of N-glycan biosynthesis";"N-Glycan biosynthesis"
Medex_00064010-RA	6	Reactome: R-HSA-156827;Reactome: R-HSA-72695;Reactome: R-HSA-72702;Reactome: R-HSA-72649;Reactome: R-HSA-72689;Reactome: R-HSA-72706	"L13a-mediated translational silencing of Ceruloplasmin expression";"Formation of the ternary complex, and subsequently, the 43S complex";"Ribosomal scanning and start codon recognition";"Translation initiation complex formation";"Formation of a pool of free 40S subunits";"GTP hydrolysis and joining of the 60S ribosomal subunit"
Medex_00042155-RA	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
Medex_00065420-RA	6	KEGG: 00073+1.2.1.84;MetaCyc: PWY-7782;MetaCyc: PWY-7656;MetaCyc: PWY-6733;Reactome: R-HSA-9640463;MetaCyc: PWY-5884	"Cutin, suberine and wax biosynthesis";"Plasmalogen biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Sporopollenin precursors biosynthesis";"Wax biosynthesis";"Wax esters biosynthesis I"
Medex_00016891-RA	1	Reactome: R-HSA-1234174	"Cellular response to hypoxia"
Medex_00046340-RA	2	Reactome: R-HSA-8964539;Reactome: R-HSA-2151201	"Glutamate and glutamine metabolism";"Transcriptional activation of mitochondrial biogenesis"
Medex_00005857-RA	2	KEGG: 00500+3.2.1.4;MetaCyc: PWY-6788	"Starch and sucrose metabolism";"Cellulose degradation II (fungi)"
Medex_00065988-RA	17	Reactome: R-HSA-9020702;Reactome: R-HSA-202424;Reactome: R-HSA-937072;Reactome: R-HSA-5357956;Reactome: R-HSA-168638;Reactome: R-HSA-450321;Reactome: R-HSA-5689880;Reactome: R-HSA-9645460;Reactome: R-HSA-445989;Reactome: R-HSA-9014325;Reactome: R-HSA-2871837;Reactome: R-HSA-4086398;Reactome: R-HSA-450302;Reactome: R-HSA-937042;Reactome: R-HSA-5607764;Reactome: R-HSA-1169091;Reactome: R-HSA-975163	"Interleukin-1 signaling";"Downstream TCR signaling";"TRAF6-mediated induction of TAK1 complex within TLR4 complex";"TNFR1-induced NFkappaB signaling pathway";"NOD1/2 Signaling Pathway";"JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1";"Ub-specific processing proteases";"Alpha-protein kinase 1 signaling pathway";"TAK1 activates NFkB by phosphorylation and activation of IKKs complex";"TICAM1,TRAF6-dependent induction of TAK1 complex";"FCERI mediated NF-kB activation";"Ca2+ pathway";"activated TAK1 mediates p38 MAPK activation";"IRAK2 mediated activation of TAK1 complex";"CLEC7A (Dectin-1) signaling";"Activation of NF-kappaB in B cells";"IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation"
Medex_00079357-RA	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
Medex_00044420-RA	4	KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16;Reactome: R-HSA-6807505;KEGG: 05235+3.1.3.16	"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation";"RNA polymerase II transcribes snRNA genes";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
Medex_00048163-RA	4	MetaCyc: PWY-7375;Reactome: R-HSA-72086;Reactome: R-HSA-167160;Reactome: R-HSA-77075	"Mrna capping I";"mRNA Capping";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"RNA Pol II CTD phosphorylation and interaction with CE"
Medex_00040553-RA	1	Reactome: R-HSA-420499	"Class C/3 (Metabotropic glutamate/pheromone receptors)"
Medex_00037262-RA	4	KEGG: 00513+2.4.1.260;Reactome: R-HSA-446193;Reactome: R-HSA-4720489;KEGG: 00510+2.4.1.260	"Various types of N-glycan biosynthesis";"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"Defective ALG12 causes ALG12-CDG (CDG-1g)";"N-Glycan biosynthesis"
Medex_00032928-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00056349-RA	1	Reactome: R-HSA-4419969	"Depolymerisation of the Nuclear Lamina"
Medex_00052540-RA	1	Reactome: R-HSA-216083	"Integrin cell surface interactions"
Medex_00032650-RA	1	Reactome: R-HSA-72165	"mRNA Splicing - Minor Pathway"
Medex_00033915-RA	5	Reactome: R-HSA-73817;MetaCyc: PWY-6121;MetaCyc: PWY-6277;KEGG: 00230+6.3.5.3;MetaCyc: PWY-6122	"Purine ribonucleoside monophosphate biosynthesis";"5-aminoimidazole ribonucleotide biosynthesis I";"Superpathway of 5-aminoimidazole ribonucleotide biosynthesis";"Purine metabolism";"5-aminoimidazole ribonucleotide biosynthesis II"
Medex_00033173-RA	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
Medex_00026063-RA	2	Reactome: R-HSA-72163;Reactome: R-HSA-6807505	"mRNA Splicing - Major Pathway";"RNA polymerase II transcribes snRNA genes"
Medex_00032325-RA	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
Medex_00008480-RA	1	Reactome: R-HSA-1296052	"Ca2+ activated K+ channels"
Medex_00086800-RA	3	KEGG: 00270+5.3.1.23;MetaCyc: PWY-7174;MetaCyc: PWY-4361	"Cysteine and methionine metabolism";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation II";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I"
Medex_00057728-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Medex_00052200-RA	17	MetaCyc: PWY-7224;MetaCyc: PWY-7184;MetaCyc: PWY-7176;MetaCyc: PWY-7187;MetaCyc: PWY-6545;MetaCyc: PWY-7222;KEGG: 00983+2.7.4.6;MetaCyc: PWY-7221;MetaCyc: PWY-7205;KEGG: 00240+2.7.4.6;MetaCyc: PWY-7210;MetaCyc: PWY-7197;MetaCyc: PWY-7220;KEGG: 00230+2.7.4.6;MetaCyc: PWY-7198;MetaCyc: PWY-7226;MetaCyc: PWY-7227	"Purine deoxyribonucleosides salvage";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"UTP and CTP de novo biosynthesis";"Pyrimidine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Guanosine deoxyribonucleotides de novo biosynthesis II";"Drug metabolism - other enzymes";"Guanosine ribonucleotides de novo biosynthesis";"CMP phosphorylation";"Pyrimidine metabolism";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Pyrimidine deoxyribonucleotide phosphorylation";"Adenosine deoxyribonucleotides de novo biosynthesis II";"Purine metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Guanosine deoxyribonucleotides de novo biosynthesis I";"Adenosine deoxyribonucleotides de novo biosynthesis"
Medex_00036537-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Medex_00028132-RA	1	Reactome: R-HSA-3295583	"TRP channels"
Medex_00021398-RA	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
Medex_00083548-RA	16	Reactome: R-HSA-6791226;Reactome: R-HSA-72702;Reactome: R-HSA-72764;Reactome: R-HSA-72706;Reactome: R-HSA-975956;Reactome: R-HSA-9633012;Reactome: R-HSA-1799339;Reactome: R-HSA-975957;Reactome: R-HSA-2408557;Reactome: R-HSA-72689;Reactome: R-HSA-156902;Reactome: R-HSA-72695;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-72649;Reactome: R-HSA-192823	"Major pathway of rRNA processing in the nucleolus and cytosol";"Ribosomal scanning and start codon recognition";"Eukaryotic Translation Termination";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Selenocysteine synthesis";"Formation of a pool of free 40S subunits";"Peptide chain elongation";"Formation of the ternary complex, and subsequently, the 43S complex";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Translation initiation complex formation";"Viral mRNA Translation"
Medex_00059771-RA	1	Reactome: R-HSA-163125	"Post-translational modification: synthesis of GPI-anchored proteins"
Medex_00002109-RA	1	Reactome: R-HSA-1660662	"Glycosphingolipid metabolism"
Medex_00053133-RA	3	Reactome: R-HSA-2029482;Reactome: R-HSA-4420097;Reactome: R-HSA-5663213	"Regulation of actin dynamics for phagocytic cup formation";"VEGFA-VEGFR2 Pathway";"RHO GTPases Activate WASPs and WAVEs"
Medex_00031761-RA	5	KEGG: 00760+2.7.1.23;Reactome: R-HSA-196807;MetaCyc: PWY-7268;MetaCyc: PWY-5083;MetaCyc: PWY-7269	"Nicotinate and nicotinamide metabolism";"Nicotinate metabolism";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"NAD/NADH phosphorylation and dephosphorylation";"NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)"
Medex_00031889-RA	56	Reactome: R-HSA-5689603;Reactome: R-HSA-5668541;Reactome: R-HSA-5687128;Reactome: R-HSA-4608870;Reactome: R-HSA-5610785;Reactome: R-HSA-5689880;Reactome: R-HSA-195253;Reactome: R-HSA-8939902;Reactome: R-HSA-75815;Reactome: R-HSA-174178;Reactome: R-HSA-5607761;Reactome: R-HSA-5610780;Reactome: R-HSA-8852276;Reactome: R-HSA-349425;Reactome: R-HSA-1236978;Reactome: R-HSA-180534;Reactome: R-HSA-5632684;Reactome: R-HSA-9020702;Reactome: R-HSA-983168;Reactome: R-HSA-202424;Reactome: R-HSA-5658442;Reactome: R-HSA-5358346;Reactome: R-HSA-8941858;Reactome: R-HSA-9010553;Reactome: R-HSA-68949;Reactome: R-HSA-211733;Reactome: R-HSA-8939236;Reactome: R-HSA-382556;Reactome: R-HSA-180585;Reactome: R-HSA-450408;Reactome: R-HSA-4641258;Reactome: R-HSA-2467813;Reactome: R-HSA-68827;Reactome: R-HSA-8948751;Reactome: R-HSA-9604323;Reactome: R-HSA-1234176;Reactome: R-HSA-69601;Reactome: R-HSA-5362768;Reactome: R-HSA-69017;Reactome: R-HSA-5676590;Reactome: R-HSA-174113;Reactome: R-HSA-4641257;Reactome: R-HSA-69481;Reactome: R-HSA-350562;Reactome: R-HSA-5678895;Reactome: R-HSA-8951664;Reactome: R-HSA-2871837;Reactome: R-HSA-174184;Reactome: R-HSA-5607764;Reactome: R-HSA-1169091;Reactome: R-HSA-174154;Reactome: R-HSA-187577;Reactome: R-HSA-174084;Reactome: R-HSA-1236974;Reactome: R-HSA-8854050;Reactome: R-HSA-5610783	"UCH proteinases";"TNFR2 non-canonical NF-kB pathway";"MAPK6/MAPK4 signaling";"Asymmetric localization of PCP proteins";"GLI3 is processed to GLI3R by the proteasome";"Ub-specific processing proteases";"Degradation of beta-catenin by the destruction complex";"Regulation of RUNX2 expression and activity";"Ubiquitin-dependent degradation of Cyclin D";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Dectin-1 mediated noncanonical NF-kB signaling";"Degradation of GLI1 by the proteasome";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Autodegradation of the E3 ubiquitin ligase COP1";"Cross-presentation of soluble exogenous antigens (endosomes)";"Vpu mediated degradation of CD4";"Hedgehog 'on' state";"Interleukin-1 signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Downstream TCR signaling";"Regulation of RAS by GAPs";"Hedgehog ligand biogenesis";"Regulation of RUNX3 expression and activity";"Regulation of expression of SLITs and ROBOs";"Orc1 removal from chromatin";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"ABC-family proteins mediated transport";"Vif-mediated degradation of APOBEC3G";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Degradation of DVL";"Separation of Sister Chromatids";"CDT1 association with the CDC6:ORC:origin complex";"Regulation of PTEN stability and activity";"Negative regulation of NOTCH4 signaling";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"CDK-mediated phosphorylation and removal of Cdc6";"NIK-->noncanonical NF-kB signaling";"SCF-beta-TrCP mediated degradation of Emi1";"Degradation of AXIN";"G2/M Checkpoints";"Regulation of ornithine decarboxylase (ODC)";"Defective CFTR causes cystic fibrosis";"Neddylation";"FCERI mediated NF-kB activation";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"CLEC7A (Dectin-1) signaling";"Activation of NF-kappaB in B cells";"APC/C:Cdc20 mediated degradation of Securin";"SCF(Skp2)-mediated degradation of p27/p21";"Autodegradation of Cdh1 by Cdh1:APC/C";"ER-Phagosome pathway";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Degradation of GLI2 by the proteasome"
Medex_00041091-RA	1	Reactome: R-HSA-6803157	"Antimicrobial peptides"
Medex_00042911-RA	29	Reactome: R-HSA-73863;Reactome: R-HSA-73776;Reactome: R-HSA-167152;Reactome: R-HSA-674695;Reactome: R-HSA-6782210;Reactome: R-HSA-167172;Reactome: R-HSA-6781823;Reactome: R-HSA-73772;Reactome: R-HSA-167200;Reactome: R-HSA-167246;Reactome: R-HSA-167160;Reactome: R-HSA-76042;Reactome: R-HSA-6782135;Reactome: R-HSA-75955;Reactome: R-HSA-167162;Reactome: R-HSA-113418;Reactome: R-HSA-73762;Reactome: R-HSA-167158;Reactome: R-HSA-5696395;Reactome: R-HSA-167161;Reactome: R-HSA-75953;Reactome: R-HSA-6781827;Reactome: R-HSA-77075;Reactome: R-HSA-427413;Reactome: R-HSA-72086;Reactome: R-HSA-5696400;Reactome: R-HSA-73779;Reactome: R-HSA-112382;Reactome: R-HSA-6796648	"RNA Polymerase I Transcription Termination";"RNA Polymerase II Promoter Escape";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Polymerase II Pre-transcription Events";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Transcription of the HIV genome";"Formation of TC-NER Pre-Incision Complex";"RNA Polymerase I Promoter Escape";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Tat-mediated elongation of the HIV-1 transcript";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Dual incision in TC-NER";"RNA Polymerase II Transcription Elongation";"RNA Polymerase II HIV Promoter Escape";"Formation of the Early Elongation Complex";"RNA Polymerase I Transcription Initiation";"Formation of the HIV-1 Early Elongation Complex";"Formation of Incision Complex in GG-NER";"HIV Transcription Initiation";"RNA Polymerase II Transcription Initiation";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"RNA Pol II CTD phosphorylation and interaction with CE";"NoRC negatively regulates rRNA expression";"mRNA Capping";"Dual Incision in GG-NER";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Formation of RNA Pol II elongation complex";"TP53 Regulates Transcription of DNA Repair Genes"
Medex_00045224-RA	2	MetaCyc: PWY-4261;KEGG: 00561+2.7.1.30	"Glycerol degradation I";"Glycerolipid metabolism"
Medex_00040530-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00038931-RA	1	KEGG: 00480+3.4.11.2	"Glutathione metabolism"
Medex_00066417-RA	14	MetaCyc: PWY-6433;MetaCyc: PWY-7036;MetaCyc: PWY-7619;MetaCyc: PWY-7602;Reactome: R-HSA-75876;MetaCyc: PWY-7035;MetaCyc: PWY-5972;MetaCyc: PWY-7601;MetaCyc: PWY-7724;MetaCyc: PWY-6598;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7725;MetaCyc: PWY-8041;MetaCyc: PWY-5080	"Hydroxylated fatty acid biosynthesis (plants)";"Very long chain fatty acid biosynthesis II";"Juniperonate biosynthesis";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Synthesis of very long-chain fatty acyl-CoAs";"(9Z)-tricosene biosynthesis";"Stearate biosynthesis I (animals)";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Sciadonate biosynthesis";"Fatty acid elongation";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Ultra-long-chain fatty acid biosynthesis";"Very long chain fatty acid biosynthesis I"
Medex_00058013-RA	8	MetaCyc: PWY-2301;Reactome: R-HSA-1855183;MetaCyc: PWY-4661;MetaCyc: PWY-6664;KEGG: 00521+5.5.1.4;MetaCyc: PWY-6372;MetaCyc: PWY-6580;KEGG: 00562+5.5.1.4	"Myo-inositol biosynthesis";"Synthesis of IP2, IP, and Ins in the cytosol";"1D-myo-inositol hexakisphosphate biosynthesis III (Spirodela polyrrhiza)";"Di-myo-inositol phosphate biosynthesis";"Streptomycin biosynthesis";"1D-myo-inositol hexakisphosphate biosynthesis IV (Dictyostelium)";"Phosphatidylinositol biosynthesis I (bacteria)";"Inositol phosphate metabolism"
Medex_00040291-RA	1	Reactome: R-HSA-9633012	"Response of EIF2AK4 (GCN2) to amino acid deficiency"
Medex_00089508-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Medex_00088415-RA	6	Reactome: R-HSA-456926;Reactome: R-HSA-416476;Reactome: R-HSA-434316;Reactome: R-HSA-399997;Reactome: R-HSA-428930;Reactome: R-HSA-418592	"Thrombin signalling through proteinase activated receptors (PARs)";"G alpha (q) signalling events";"Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion";"Acetylcholine regulates insulin secretion";"Thromboxane signalling through TP receptor";"ADP signalling through P2Y purinoceptor 1"
Medex_00008373-RA	1	Reactome: R-HSA-352230	"Amino acid transport across the plasma membrane"
Medex_00073857-RA	2	Reactome: R-HSA-373080;Reactome: R-HSA-3238698	"Class B/2 (Secretin family receptors)";"WNT ligand biogenesis and trafficking"
Medex_00093949-RA	56	Reactome: R-HSA-9010553;Reactome: R-HSA-211733;Reactome: R-HSA-382556;Reactome: R-HSA-68949;Reactome: R-HSA-8939236;Reactome: R-HSA-180585;Reactome: R-HSA-450408;Reactome: R-HSA-4641258;Reactome: R-HSA-2467813;Reactome: R-HSA-9020702;Reactome: R-HSA-983168;Reactome: R-HSA-202424;Reactome: R-HSA-5658442;Reactome: R-HSA-5358346;Reactome: R-HSA-8941858;Reactome: R-HSA-174178;Reactome: R-HSA-5607761;Reactome: R-HSA-5610780;Reactome: R-HSA-8852276;Reactome: R-HSA-1236978;Reactome: R-HSA-349425;Reactome: R-HSA-180534;Reactome: R-HSA-5632684;Reactome: R-HSA-5687128;Reactome: R-HSA-5689603;Reactome: R-HSA-5668541;Reactome: R-HSA-4608870;Reactome: R-HSA-5689880;Reactome: R-HSA-5610785;Reactome: R-HSA-195253;Reactome: R-HSA-8939902;Reactome: R-HSA-75815;Reactome: R-HSA-1236974;Reactome: R-HSA-8854050;Reactome: R-HSA-5610783;Reactome: R-HSA-187577;Reactome: R-HSA-174084;Reactome: R-HSA-8951664;Reactome: R-HSA-2871837;Reactome: R-HSA-174184;Reactome: R-HSA-5607764;Reactome: R-HSA-1169091;Reactome: R-HSA-174154;Reactome: R-HSA-9604323;Reactome: R-HSA-8948751;Reactome: R-HSA-68827;Reactome: R-HSA-5362768;Reactome: R-HSA-1234176;Reactome: R-HSA-69017;Reactome: R-HSA-69601;Reactome: R-HSA-5676590;Reactome: R-HSA-174113;Reactome: R-HSA-4641257;Reactome: R-HSA-5678895;Reactome: R-HSA-69481;Reactome: R-HSA-350562	"Regulation of expression of SLITs and ROBOs";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"ABC-family proteins mediated transport";"Orc1 removal from chromatin";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Vif-mediated degradation of APOBEC3G";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Degradation of DVL";"Separation of Sister Chromatids";"Interleukin-1 signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Downstream TCR signaling";"Regulation of RAS by GAPs";"Hedgehog ligand biogenesis";"Regulation of RUNX3 expression and activity";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Dectin-1 mediated noncanonical NF-kB signaling";"Degradation of GLI1 by the proteasome";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Cross-presentation of soluble exogenous antigens (endosomes)";"Autodegradation of the E3 ubiquitin ligase COP1";"Vpu mediated degradation of CD4";"Hedgehog 'on' state";"MAPK6/MAPK4 signaling";"UCH proteinases";"TNFR2 non-canonical NF-kB pathway";"Asymmetric localization of PCP proteins";"Ub-specific processing proteases";"GLI3 is processed to GLI3R by the proteasome";"Degradation of beta-catenin by the destruction complex";"Regulation of RUNX2 expression and activity";"Ubiquitin-dependent degradation of Cyclin D";"ER-Phagosome pathway";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Degradation of GLI2 by the proteasome";"SCF(Skp2)-mediated degradation of p27/p21";"Autodegradation of Cdh1 by Cdh1:APC/C";"Neddylation";"FCERI mediated NF-kB activation";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"CLEC7A (Dectin-1) signaling";"Activation of NF-kappaB in B cells";"APC/C:Cdc20 mediated degradation of Securin";"Negative regulation of NOTCH4 signaling";"Regulation of PTEN stability and activity";"CDT1 association with the CDC6:ORC:origin complex";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"CDK-mediated phosphorylation and removal of Cdc6";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"NIK-->noncanonical NF-kB signaling";"SCF-beta-TrCP mediated degradation of Emi1";"Degradation of AXIN";"Defective CFTR causes cystic fibrosis";"G2/M Checkpoints";"Regulation of ornithine decarboxylase (ODC)"
Medex_00072257-RA	1	Reactome: R-HSA-3299685	"Detoxification of Reactive Oxygen Species"
Medex_00084134-RA	1	Reactome: R-HSA-211981	"Xenobiotics"
Medex_00063915-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Medex_00022160-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Medex_00037261-RA	4	Reactome: R-HSA-446193;Reactome: R-HSA-4720489;KEGG: 00513+2.4.1.260;KEGG: 00510+2.4.1.260	"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"Defective ALG12 causes ALG12-CDG (CDG-1g)";"Various types of N-glycan biosynthesis";"N-Glycan biosynthesis"
Medex_00003319-RA	14	MetaCyc: PWY-5080;MetaCyc: PWY-8041;KEGG: 00062+2.3.1.199;MetaCyc: PWY-6598;MetaCyc: PWY-7725;MetaCyc: PWY-7724;MetaCyc: PWY-7601;MetaCyc: PWY-7035;Reactome: R-HSA-75876;MetaCyc: PWY-5972;MetaCyc: PWY-7036;MetaCyc: PWY-7602;MetaCyc: PWY-7619;MetaCyc: PWY-6433	"Very long chain fatty acid biosynthesis I";"Ultra-long-chain fatty acid biosynthesis";"Fatty acid elongation";"Sciadonate biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"(9Z)-tricosene biosynthesis";"Synthesis of very long-chain fatty acyl-CoAs";"Stearate biosynthesis I (animals)";"Very long chain fatty acid biosynthesis II";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Juniperonate biosynthesis";"Hydroxylated fatty acid biosynthesis (plants)"
Medex_00051228-RA	1	KEGG: 00970+6.1.1.9	"Aminoacyl-tRNA biosynthesis"
Medex_00082077-RA	4	Reactome: R-HSA-186763;Reactome: R-HSA-8875555;Reactome: R-HSA-8875656;Reactome: R-HSA-912631	"Downstream signal transduction";"MET activates RAP1 and RAC1";"MET receptor recycling";"Regulation of signaling by CBL"
Medex_00020287-RA	1	Reactome: R-HSA-71403	"Citric acid cycle (TCA cycle)"
Medex_00000346-RA	6	Reactome: R-HSA-429958;Reactome: R-HSA-450604;Reactome: R-HSA-450385;Reactome: R-HSA-450513;Reactome: R-HSA-380994;Reactome: R-HSA-6791226	"mRNA decay by 3' to 5' exoribonuclease";"KSRP (KHSRP) binds and destabilizes mRNA";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"ATF4 activates genes in response to endoplasmic reticulum stress";"Major pathway of rRNA processing in the nucleolus and cytosol"
Medex_00073044-RA	1	Reactome: R-HSA-430039	"mRNA decay by 5' to 3' exoribonuclease"
Medex_00083218-RA	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
Medex_00014182-RA	1	KEGG: 00970+6.1.1.19	"Aminoacyl-tRNA biosynthesis"
Medex_00036560-RA	13	MetaCyc: PWY-7112;MetaCyc: PWY-6370;MetaCyc: PWY-4061;Reactome: R-HSA-156590;MetaCyc: PWY-6842;KEGG: 00053+1.8.5.1;KEGG: 00982+2.5.1.18;MetaCyc: PWY-7533;KEGG: 00983+2.5.1.18;MetaCyc: PWY-2261;KEGG: 00480+2.5.1.18+1.8.5.1;Reactome: R-HSA-196836;KEGG: 00980+2.5.1.18	"4-hydroxy-2-nonenal detoxification";"Ascorbate recycling (cytosolic)";"Glutathione-mediated detoxification I";"Glutathione conjugation";"Glutathione-mediated detoxification II";"Ascorbate and aldarate metabolism";"Drug metabolism - cytochrome P450";"Gliotoxin biosynthesis";"Drug metabolism - other enzymes";"Ascorbate glutathione cycle";"Glutathione metabolism";"Vitamin C (ascorbate) metabolism";"Metabolism of xenobiotics by cytochrome P450"
Medex_00050913-RA	1	Reactome: R-HSA-71288	"Creatine metabolism"
Medex_00044803-RA	1	Reactome: R-HSA-6803157	"Antimicrobial peptides"
Medex_00014508-RA	5	Reactome: R-HSA-176407;KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;Reactome: R-HSA-5687128	"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"MAPK6/MAPK4 signaling"
Medex_00002530-RA	1	Reactome: R-HSA-5578775	"Ion homeostasis"
Medex_00012571-RA	3	MetaCyc: PWY-6348;KEGG: 00730+3.1.3.2;KEGG: 00740+3.1.3.2	"Phosphate acquisition";"Thiamine metabolism";"Riboflavin metabolism"
Medex_00052577-RA	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
Medex_00053772-RA	1	Reactome: R-HSA-8856828	"Clathrin-mediated endocytosis"
Medex_00019504-RA	11	MetaCyc: PWY-7254;MetaCyc: PWY-6728;MetaCyc: PWY-5913;MetaCyc: PWY-6969;Reactome: R-HSA-71403;MetaCyc: PWY-6549;MetaCyc: PWY-7124;KEGG: 00720+1.1.1.42;MetaCyc: PWY-7268;KEGG: 00020+1.1.1.42;KEGG: 00480+1.1.1.42	"TCA cycle VII (acetate-producers)";"Methylaspartate cycle";"Partial TCA cycle (obligate autotrophs)";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Citric acid cycle (TCA cycle)";"L-glutamine biosynthesis III";"Ethylene biosynthesis V (engineered)";"Carbon fixation pathways in prokaryotes";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"Citrate cycle (TCA cycle)";"Glutathione metabolism"
Medex_00062836-RA	2	Reactome: R-HSA-8951664;Reactome: R-HSA-983168	"Neddylation";"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00013128-RA	2	KEGG: 00520+2.4.1.16;MetaCyc: PWY-6981	"Amino sugar and nucleotide sugar metabolism";"Chitin biosynthesis"
Medex_00012916-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00039217-RA	1	KEGG: 00970+6.1.1.3	"Aminoacyl-tRNA biosynthesis"
Medex_00037230-RA	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
Medex_00059770-RA	1	Reactome: R-HSA-163125	"Post-translational modification: synthesis of GPI-anchored proteins"
Medex_00021875-RA	2	Reactome: R-HSA-983168;Reactome: R-HSA-8951664	"Antigen processing: Ubiquitination & Proteasome degradation";"Neddylation"
Medex_00053046-RA	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00076048-RA	1	Reactome: R-HSA-203927	"MicroRNA (miRNA) biogenesis"
Medex_00055825-RA	1	Reactome: R-HSA-400253	"Circadian Clock"
Medex_00034041-RA	10	Reactome: R-HSA-9615017;Reactome: R-HSA-9022702;Reactome: R-HSA-983231;Reactome: R-HSA-9022699;Reactome: R-HSA-9022692;Reactome: R-HSA-400206;Reactome: R-HSA-9022538;Reactome: R-HSA-427413;Reactome: R-HSA-3899300;Reactome: R-HSA-8936459	"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"MECP2 regulates transcription of neuronal ligands";"Factors involved in megakaryocyte development and platelet production";"MECP2 regulates neuronal receptors and channels";"Regulation of MECP2 expression and activity";"Regulation of lipid metabolism by PPARalpha";"Loss of MECP2 binding ability to 5mC-DNA";"NoRC negatively regulates rRNA expression";"SUMOylation of transcription cofactors";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"
Medex_00042103-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Medex_00077246-RA	4	Reactome: R-HSA-975871;Reactome: R-HSA-166058;Reactome: R-HSA-6799198;Reactome: R-HSA-975138	"MyD88 cascade initiated on plasma membrane";"MyD88:MAL(TIRAP) cascade initiated on plasma membrane";"Complex I biogenesis";"TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation"
Medex_00071729-RA	1	Reactome: R-HSA-204626	"Hypusine synthesis from eIF5A-lysine"
Medex_00045496-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00006433-RA	3	KEGG: 00500+2.4.1.11;MetaCyc: PWY-5067;Reactome: R-HSA-3322077	"Starch and sucrose metabolism";"Glycogen biosynthesis II (from UDP-D-Glucose)";"Glycogen synthesis"
Medex_00013949-RA	56	Reactome: R-HSA-5668541;Reactome: R-HSA-5689603;Reactome: R-HSA-5687128;Reactome: R-HSA-4608870;Reactome: R-HSA-5610785;Reactome: R-HSA-5689880;Reactome: R-HSA-195253;Reactome: R-HSA-8939902;Reactome: R-HSA-75815;Reactome: R-HSA-174178;Reactome: R-HSA-5607761;Reactome: R-HSA-8852276;Reactome: R-HSA-5610780;Reactome: R-HSA-349425;Reactome: R-HSA-1236978;Reactome: R-HSA-180534;Reactome: R-HSA-5632684;Reactome: R-HSA-9020702;Reactome: R-HSA-983168;Reactome: R-HSA-202424;Reactome: R-HSA-5658442;Reactome: R-HSA-8941858;Reactome: R-HSA-5358346;Reactome: R-HSA-9010553;Reactome: R-HSA-68949;Reactome: R-HSA-382556;Reactome: R-HSA-8939236;Reactome: R-HSA-211733;Reactome: R-HSA-180585;Reactome: R-HSA-450408;Reactome: R-HSA-4641258;Reactome: R-HSA-2467813;Reactome: R-HSA-9604323;Reactome: R-HSA-8948751;Reactome: R-HSA-68827;Reactome: R-HSA-69601;Reactome: R-HSA-5362768;Reactome: R-HSA-69017;Reactome: R-HSA-1234176;Reactome: R-HSA-5676590;Reactome: R-HSA-174113;Reactome: R-HSA-4641257;Reactome: R-HSA-69481;Reactome: R-HSA-5678895;Reactome: R-HSA-350562;Reactome: R-HSA-8951664;Reactome: R-HSA-2871837;Reactome: R-HSA-5607764;Reactome: R-HSA-174184;Reactome: R-HSA-1169091;Reactome: R-HSA-174154;Reactome: R-HSA-187577;Reactome: R-HSA-174084;Reactome: R-HSA-1236974;Reactome: R-HSA-8854050;Reactome: R-HSA-5610783	"TNFR2 non-canonical NF-kB pathway";"UCH proteinases";"MAPK6/MAPK4 signaling";"Asymmetric localization of PCP proteins";"GLI3 is processed to GLI3R by the proteasome";"Ub-specific processing proteases";"Degradation of beta-catenin by the destruction complex";"Regulation of RUNX2 expression and activity";"Ubiquitin-dependent degradation of Cyclin D";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Dectin-1 mediated noncanonical NF-kB signaling";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Degradation of GLI1 by the proteasome";"Autodegradation of the E3 ubiquitin ligase COP1";"Cross-presentation of soluble exogenous antigens (endosomes)";"Vpu mediated degradation of CD4";"Hedgehog 'on' state";"Interleukin-1 signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Downstream TCR signaling";"Regulation of RAS by GAPs";"Regulation of RUNX3 expression and activity";"Hedgehog ligand biogenesis";"Regulation of expression of SLITs and ROBOs";"Orc1 removal from chromatin";"ABC-family proteins mediated transport";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Vif-mediated degradation of APOBEC3G";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Degradation of DVL";"Separation of Sister Chromatids";"Negative regulation of NOTCH4 signaling";"Regulation of PTEN stability and activity";"CDT1 association with the CDC6:ORC:origin complex";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"CDK-mediated phosphorylation and removal of Cdc6";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"NIK-->noncanonical NF-kB signaling";"SCF-beta-TrCP mediated degradation of Emi1";"Degradation of AXIN";"G2/M Checkpoints";"Defective CFTR causes cystic fibrosis";"Regulation of ornithine decarboxylase (ODC)";"Neddylation";"FCERI mediated NF-kB activation";"CLEC7A (Dectin-1) signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Activation of NF-kappaB in B cells";"APC/C:Cdc20 mediated degradation of Securin";"SCF(Skp2)-mediated degradation of p27/p21";"Autodegradation of Cdh1 by Cdh1:APC/C";"ER-Phagosome pathway";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Degradation of GLI2 by the proteasome"
Medex_00037432-RA	5	Reactome: R-HSA-350054;Reactome: R-HSA-2894862;Reactome: R-HSA-2644606;Reactome: R-HSA-2122947;Reactome: R-HSA-3214815	"Notch-HLH transcription pathway";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH1 Intracellular Domain Regulates Transcription";"HDACs deacetylate histones"
Medex_00031628-RA	4	MetaCyc: PWY-7219;Reactome: R-HSA-499943;KEGG: 00730+2.7.4.3;KEGG: 00230+2.7.4.3	"Adenosine ribonucleotides de novo biosynthesis";"Interconversion of nucleotide di- and triphosphates";"Thiamine metabolism";"Purine metabolism"
Medex_00072535-RA	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
Medex_00022566-RA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00007116-RA	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
Medex_00059176-RA	5	Reactome: R-HSA-4341670;Reactome: R-HSA-1660662;Reactome: R-HSA-4085001;Reactome: R-HSA-2132295;Reactome: R-HSA-6798695	"Defective NEU1 causes sialidosis";"Glycosphingolipid metabolism";"Sialic acid metabolism";"MHC class II antigen presentation";"Neutrophil degranulation"
Medex_00099903-RA	2	Reactome: R-HSA-375276;Reactome: R-HSA-418594	"Peptide ligand-binding receptors";"G alpha (i) signalling events"
Medex_00031299-RA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Medex_00007282-RA	3	MetaCyc: PWY-3961;KEGG: 00770+2.7.1.33;Reactome: R-HSA-196783	"Phosphopantothenate biosynthesis II";"Pantothenate and CoA biosynthesis";"Coenzyme A biosynthesis"
Medex_00016964-RA	7	Reactome: R-HSA-380259;Reactome: R-HSA-2565942;Reactome: R-HSA-8854518;Reactome: R-HSA-380270;Reactome: R-HSA-380320;Reactome: R-HSA-5620912;Reactome: R-HSA-380284	"Loss of Nlp from mitotic centrosomes";"Regulation of PLK1 Activity at G2/M Transition";"AURKA Activation by TPX2";"Recruitment of mitotic centrosome proteins and complexes";"Recruitment of NuMA to mitotic centrosomes";"Anchoring of the basal body to the plasma membrane";"Loss of proteins required for interphase microtubule organization from the centrosome"
Medex_00050241-RA	3	Reactome: R-HSA-212436;Reactome: R-HSA-381340;Reactome: R-HSA-1989781	"Generic Transcription Pathway";"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression"
Medex_00062733-RA	40	Reactome: R-HSA-6803529;Reactome: R-HSA-6781827;Reactome: R-HSA-167158;Reactome: R-HSA-72203;Reactome: R-HSA-168325;Reactome: R-HSA-77075;Reactome: R-HSA-167238;Reactome: R-HSA-6796648;Reactome: R-HSA-72086;Reactome: R-HSA-674695;Reactome: R-HSA-167152;Reactome: R-HSA-73776;Reactome: R-HSA-167287;Reactome: R-HSA-167243;Reactome: R-HSA-6782210;Reactome: R-HSA-72165;Reactome: R-HSA-167162;Reactome: R-HSA-76042;Reactome: R-HSA-6807505;Reactome: R-HSA-113418;Reactome: R-HSA-167161;Reactome: R-HSA-75953;Reactome: R-HSA-8851708;Reactome: R-HSA-112382;Reactome: R-HSA-73779;Reactome: R-HSA-72163;Reactome: R-HSA-167172;Reactome: R-HSA-6781823;Reactome: R-HSA-167290;Reactome: R-HSA-167242;Reactome: R-HSA-167160;Reactome: R-HSA-5578749;Reactome: R-HSA-167246;Reactome: R-HSA-167200;Reactome: R-HSA-9018519;Reactome: R-HSA-75955;Reactome: R-HSA-6782135;Reactome: R-HSA-5617472;Reactome: R-HSA-203927;Reactome: R-HSA-5601884	"FGFR2 alternative splicing";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Formation of the HIV-1 Early Elongation Complex";"Processing of Capped Intron-Containing Pre-mRNA";"Viral Messenger RNA Synthesis";"RNA Pol II CTD phosphorylation and interaction with CE";"Pausing and recovery of Tat-mediated HIV elongation";"TP53 Regulates Transcription of DNA Repair Genes";"mRNA Capping";"RNA Polymerase II Pre-transcription Events";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Polymerase II Promoter Escape";"HIV elongation arrest and recovery";"Tat-mediated HIV elongation arrest and recovery";"Gap-filling DNA repair synthesis and ligation in TC-NER";"mRNA Splicing - Minor Pathway";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA polymerase II transcribes snRNA genes";"Formation of the Early Elongation Complex";"HIV Transcription Initiation";"RNA Polymerase II Transcription Initiation";"Signaling by FGFR2 IIIa TM";"Formation of RNA Pol II elongation complex";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"mRNA Splicing - Major Pathway";"Transcription of the HIV genome";"Formation of TC-NER Pre-Incision Complex";"Pausing and recovery of HIV elongation";"Abortive elongation of HIV-1 transcript in the absence of Tat";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Transcriptional regulation by small RNAs";"Tat-mediated elongation of the HIV-1 transcript";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Estrogen-dependent gene expression";"RNA Polymerase II Transcription Elongation";"Dual incision in TC-NER";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"MicroRNA (miRNA) biogenesis";"PIWI-interacting RNA (piRNA) biogenesis"
Medex_00059807-RA	3	Reactome: R-HSA-1445148;Reactome: R-HSA-5620916;Reactome: R-HSA-264876	"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"VxPx cargo-targeting to cilium";"Insulin processing"
Medex_00068874-RA	14	Reactome: R-HSA-2467813;Reactome: R-HSA-9646399;Reactome: R-HSA-68877;Reactome: R-HSA-9648025;Reactome: R-HSA-1632852;Reactome: R-HSA-5663220;Reactome: R-HSA-6807878;Reactome: R-HSA-6811436;Reactome: R-HSA-9609690;Reactome: R-HSA-141444;Reactome: R-HSA-5620924;Reactome: R-HSA-2500257;Reactome: R-HSA-3371497;Reactome: R-HSA-2132295	"Separation of Sister Chromatids";"Aggrephagy";"Mitotic Prometaphase";"EML4 and NUDC in mitotic spindle formation";"Macroautophagy";"RHO GTPases Activate Formins";"COPI-mediated anterograde transport";"COPI-independent Golgi-to-ER retrograde traffic";"HCMV Early Events";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Intraflagellar transport";"Resolution of Sister Chromatid Cohesion";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"MHC class II antigen presentation"
Medex_00007022-RA	1	Reactome: R-HSA-2142789	"Ubiquinol biosynthesis"
Medex_00074979-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00045314-RA	10	MetaCyc: PWY-7117;MetaCyc: PWY-5744;MetaCyc: PWY-7115;MetaCyc: PWY-5789;Reactome: R-HSA-1475029;KEGG: 00910+4.2.1.1;MetaCyc: PWY-6142;Reactome: R-HSA-1234158;MetaCyc: PWY-5743;MetaCyc: PWY-241	"C4 photosynthetic carbon assimilation cycle, PEPCK type";"Glyoxylate assimilation";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Reversible hydration of carbon dioxide";"Nitrogen metabolism";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Regulation of gene expression by Hypoxia-inducible Factor";"3-hydroxypropanoate cycle";"C4 photosynthetic carbon assimilation cycle, NADP-ME type"
Medex_00022268-RA	2	MetaCyc: PWY-4261;KEGG: 00561+2.7.1.30	"Glycerol degradation I";"Glycerolipid metabolism"
Medex_00090375-RA	2	Reactome: R-HSA-3214858;Reactome: R-HSA-8939243	"RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"
Medex_00080861-RA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Medex_00044394-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Medex_00022589-RA	13	Reactome: R-HSA-1489509;Reactome: R-HSA-983695;Reactome: R-HSA-139853;Reactome: R-HSA-112043;Reactome: R-HSA-422356;Reactome: R-HSA-2029485;Reactome: R-HSA-114508;Reactome: R-HSA-5607763;Reactome: R-HSA-5578775;Reactome: R-HSA-2871809;Reactome: R-HSA-4086398;Reactome: R-HSA-381676;Reactome: R-HSA-5218921	"DAG and IP3 signaling";"Antigen activates B Cell Receptor (BCR) leading to generation of second messengers";"Elevation of cytosolic Ca2+ levels";"PLC beta mediated events";"Regulation of insulin secretion";"Role of phospholipids in phagocytosis";"Effects of PIP2 hydrolysis";"CLEC7A (Dectin-1) induces NFAT activation";"Ion homeostasis";"FCERI mediated Ca+2 mobilization";"Ca2+ pathway";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"VEGFR2 mediated cell proliferation"
Medex_00073162-RA	1	Reactome: R-HSA-202733	"Cell surface interactions at the vascular wall"
Medex_00047890-RA	8	MetaCyc: PWY-7197;MetaCyc: PWY-7187;MetaCyc: PWY-7184;MetaCyc: PWY-7198;Reactome: R-HSA-499943;MetaCyc: PWY-6545;MetaCyc: PWY-7210;KEGG: 00240+2.7.4.9	"Pyrimidine deoxyribonucleotide phosphorylation";"Pyrimidine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Interconversion of nucleotide di- and triphosphates";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Pyrimidine metabolism"
Medex_00067470-RA	2	Reactome: R-HSA-9610379;Reactome: R-HSA-917729	"HCMV Late Events";"Endosomal Sorting Complex Required For Transport (ESCRT)"
Medex_00068361-RA	1	Reactome: R-HSA-5689896	"Ovarian tumor domain proteases"
Medex_00054442-RA	1	Reactome: R-HSA-1474228	"Degradation of the extracellular matrix"
Medex_00006164-RA	2	Reactome: R-HSA-5628897;Reactome: R-HSA-611105	"TP53 Regulates Metabolic Genes";"Respiratory electron transport"
Medex_00003516-RA	2	Reactome: R-HSA-9634600;KEGG: 00051+2.7.1.105+3.1.3.46	"Regulation of glycolysis by fructose 2,6-bisphosphate metabolism";"Fructose and mannose metabolism"
Medex_00020025-RA	3	MetaCyc: PWY-6117;MetaCyc: PWY-0;KEGG: 00330+2.3.1.57	"Spermine and spermidine degradation I";"Putrescine degradation III";"Arginine and proline metabolism"
Medex_00045929-RA	6	MetaCyc: PWY-6731;Reactome: R-HSA-70221;MetaCyc: PWY-7238;MetaCyc: PWY-6737;KEGG: 00500+2.4.1.1;MetaCyc: PWY-5941	"Starch degradation III";"Glycogen breakdown (glycogenolysis)";"Sucrose biosynthesis II";"Starch degradation V";"Starch and sucrose metabolism";"Glycogen degradation II"
Medex_00014484-RA	4	KEGG: 00330+4.1.1.50;MetaCyc: PWY-6834;KEGG: 00270+4.1.1.50;Reactome: R-HSA-351202	"Arginine and proline metabolism";"Spermidine biosynthesis III";"Cysteine and methionine metabolism";"Metabolism of polyamines"
Medex_00024150-RA	3	Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-212436	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"Generic Transcription Pathway"
Medex_00055836-RA	2	Reactome: R-HSA-6804115;Reactome: R-HSA-429947	"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Deadenylation of mRNA"
Medex_00006298-RA	3	KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16	"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
Medex_00018849-RA	7	KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1	"Human cytomegalovirus infection";"Relaxin signaling pathway";"Thermogenesis";"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection"
Medex_00032963-RA	3	Reactome: R-HSA-416482;Reactome: R-HSA-194840;Reactome: R-HSA-193648	"G alpha (12/13) signalling events";"Rho GTPase cycle";"NRAGE signals death through JNK"
Medex_00060206-RA	7	Reactome: R-HSA-212436;Reactome: R-HSA-2894862;Reactome: R-HSA-2173796;Reactome: R-HSA-2644606;Reactome: R-HSA-381340;Reactome: R-HSA-2122947;Reactome: R-HSA-1989781	"Generic Transcription Pathway";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Transcriptional regulation of white adipocyte differentiation";"NOTCH1 Intracellular Domain Regulates Transcription";"PPARA activates gene expression"
Medex_00017246-RA	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
Medex_00020505-RA	3	KEGG: 00600+3.2.1.45;KEGG: 00511+3.2.1.45;Reactome: R-HSA-1660662	"Sphingolipid metabolism";"Other glycan degradation";"Glycosphingolipid metabolism"
Medex_00047618-RA	3	Reactome: R-HSA-2151201;Reactome: R-HSA-5689603;Reactome: R-HSA-3214847	"Transcriptional activation of mitochondrial biogenesis";"UCH proteinases";"HATs acetylate histones"
Medex_00062416-RA	4	Reactome: R-HSA-2029482;Reactome: R-HSA-8856828;Reactome: R-HSA-5663213;Reactome: R-HSA-3928662	"Regulation of actin dynamics for phagocytic cup formation";"Clathrin-mediated endocytosis";"RHO GTPases Activate WASPs and WAVEs";"EPHB-mediated forward signaling"
Medex_00081824-RA	5	Reactome: R-HSA-6782135;Reactome: R-HSA-6781823;Reactome: R-HSA-72163;Reactome: R-HSA-6781827;Reactome: R-HSA-6782210	"Dual incision in TC-NER";"Formation of TC-NER Pre-Incision Complex";"mRNA Splicing - Major Pathway";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Gap-filling DNA repair synthesis and ligation in TC-NER"
Medex_00074151-RA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Medex_00031120-RA	57	Reactome: R-HSA-2871837;Reactome: R-HSA-8951664;Reactome: R-HSA-174154;Reactome: R-HSA-1169091;Reactome: R-HSA-174184;Reactome: R-HSA-5607764;Reactome: R-HSA-5676590;Reactome: R-HSA-69017;Reactome: R-HSA-1234176;Reactome: R-HSA-69601;Reactome: R-HSA-5362768;Reactome: R-HSA-9604323;Reactome: R-HSA-68827;Reactome: R-HSA-8948751;Reactome: R-HSA-350562;Reactome: R-HSA-5678895;Reactome: R-HSA-69481;Reactome: R-HSA-4641257;Reactome: R-HSA-174113;Reactome: R-HSA-5610783;Reactome: R-HSA-8854050;Reactome: R-HSA-1236974;Reactome: R-HSA-174084;Reactome: R-HSA-187577;Reactome: R-HSA-8852276;Reactome: R-HSA-5610780;Reactome: R-HSA-5607761;Reactome: R-HSA-174178;Reactome: R-HSA-5632684;Reactome: R-HSA-180534;Reactome: R-HSA-1236978;Reactome: R-HSA-349425;Reactome: R-HSA-5610785;Reactome: R-HSA-5689880;Reactome: R-HSA-4608870;Reactome: R-HSA-5668541;Reactome: R-HSA-5689603;Reactome: R-HSA-5687128;Reactome: R-HSA-75815;Reactome: R-HSA-8939902;Reactome: R-HSA-195253;Reactome: R-HSA-382556;Reactome: R-HSA-211733;Reactome: R-HSA-8939236;Reactome: R-HSA-68949;Reactome: R-HSA-9010553;Reactome: R-HSA-2467813;Reactome: R-HSA-4641258;Reactome: R-HSA-450408;Reactome: R-HSA-180585;Reactome: R-HSA-9020702;Reactome: R-HSA-6798695;Reactome: R-HSA-5358346;Reactome: R-HSA-8941858;Reactome: R-HSA-5658442;Reactome: R-HSA-202424;Reactome: R-HSA-983168	"FCERI mediated NF-kB activation";"Neddylation";"APC/C:Cdc20 mediated degradation of Securin";"Activation of NF-kappaB in B cells";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"CLEC7A (Dectin-1) signaling";"NIK-->noncanonical NF-kB signaling";"CDK-mediated phosphorylation and removal of Cdc6";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Negative regulation of NOTCH4 signaling";"CDT1 association with the CDC6:ORC:origin complex";"Regulation of PTEN stability and activity";"Regulation of ornithine decarboxylase (ODC)";"Defective CFTR causes cystic fibrosis";"G2/M Checkpoints";"Degradation of AXIN";"SCF-beta-TrCP mediated degradation of Emi1";"Degradation of GLI2 by the proteasome";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"ER-Phagosome pathway";"Autodegradation of Cdh1 by Cdh1:APC/C";"SCF(Skp2)-mediated degradation of p27/p21";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Degradation of GLI1 by the proteasome";"Dectin-1 mediated noncanonical NF-kB signaling";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Hedgehog 'on' state";"Vpu mediated degradation of CD4";"Cross-presentation of soluble exogenous antigens (endosomes)";"Autodegradation of the E3 ubiquitin ligase COP1";"GLI3 is processed to GLI3R by the proteasome";"Ub-specific processing proteases";"Asymmetric localization of PCP proteins";"TNFR2 non-canonical NF-kB pathway";"UCH proteinases";"MAPK6/MAPK4 signaling";"Ubiquitin-dependent degradation of Cyclin D";"Regulation of RUNX2 expression and activity";"Degradation of beta-catenin by the destruction complex";"ABC-family proteins mediated transport";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Orc1 removal from chromatin";"Regulation of expression of SLITs and ROBOs";"Separation of Sister Chromatids";"Degradation of DVL";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Vif-mediated degradation of APOBEC3G";"Interleukin-1 signaling";"Neutrophil degranulation";"Hedgehog ligand biogenesis";"Regulation of RUNX3 expression and activity";"Regulation of RAS by GAPs";"Downstream TCR signaling";"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00058750-RA	2	Reactome: R-HSA-389661;Reactome: R-HSA-2408508	"Glyoxylate metabolism and glycine degradation";"Metabolism of ingested SeMet, Sec, MeSec into H2Se"
Medex_00031161-RA	1	Reactome: R-HSA-5358493	"Synthesis of diphthamide-EEF2"
Medex_00003415-RA	4	Reactome: R-HSA-3656532;Reactome: R-HSA-2173789;Reactome: R-HSA-3304356;Reactome: R-HSA-2173788	"TGFBR1 KD Mutants in Cancer";"TGF-beta receptor signaling activates SMADs";"SMAD2/3 Phosphorylation Motif Mutants in Cancer";"Downregulation of TGF-beta receptor signaling"
Medex_00006711-RA	1	Reactome: R-HSA-197264	"Nicotinamide salvaging"
Medex_00011498-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00011495-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Medex_00077145-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00054324-RA	3	Reactome: R-HSA-73856;Reactome: R-HSA-72187;Reactome: R-HSA-159236	"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing";"Transport of Mature mRNA derived from an Intron-Containing Transcript"
Medex_00083180-RA	4	KEGG: 00380+1.2.4.2;KEGG: 00020+1.2.4.2;KEGG: 00310+1.2.4.2;MetaCyc: PWY-5084	"Tryptophan metabolism";"Citrate cycle (TCA cycle)";"Lysine degradation";"2-oxoglutarate decarboxylation to succinyl-CoA"
Medex_00031454-RA	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
Medex_00063460-RA	1	Reactome: R-HSA-611105	"Respiratory electron transport"
Medex_00044278-RA	10	Reactome: R-HSA-72649;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-72695;Reactome: R-HSA-382556;Reactome: R-HSA-9648895;Reactome: R-HSA-72702;Reactome: R-HSA-72731;Reactome: R-HSA-381042;Reactome: R-HSA-72706	"Translation initiation complex formation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Formation of the ternary complex, and subsequently, the 43S complex";"ABC-family proteins mediated transport";"Response of EIF2AK1 (HRI) to heme deficiency";"Ribosomal scanning and start codon recognition";"Recycling of eIF2:GDP";"PERK regulates gene expression";"GTP hydrolysis and joining of the 60S ribosomal subunit"
Medex_00082294-RA	5	KEGG: 04070+2.7.7.41;MetaCyc: PWY-7817;MetaCyc: PWY-5667;KEGG: 00564+2.7.7.41;MetaCyc: PWY-5981	"Phosphatidylinositol signaling system";"Type I lipoteichoic acid biosynthesis (S. aureus)";"CDP-diacylglycerol biosynthesis I";"Glycerophospholipid metabolism";"CDP-diacylglycerol biosynthesis III"
Medex_00088612-RA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
Medex_00080709-RA	37	Reactome: R-HSA-5663220;Reactome: R-HSA-159230;Reactome: R-HSA-204005;Reactome: R-HSA-159227;Reactome: R-HSA-9648025;Reactome: R-HSA-159231;Reactome: R-HSA-68877;Reactome: R-HSA-1169408;Reactome: R-HSA-2467813;Reactome: R-HSA-168333;Reactome: R-HSA-168325;Reactome: R-HSA-191859;Reactome: R-HSA-141444;Reactome: R-HSA-4551638;Reactome: R-HSA-170822;Reactome: R-HSA-3232142;Reactome: R-HSA-983170;Reactome: R-HSA-168271;Reactome: R-HSA-5578749;Reactome: R-HSA-2500257;Reactome: R-HSA-168276;Reactome: R-HSA-3371453;Reactome: R-HSA-4615885;Reactome: R-HSA-180746;Reactome: R-HSA-9639288;Reactome: R-HSA-165054;Reactome: R-HSA-2132295;Reactome: R-HSA-159236;Reactome: R-HSA-3108214;Reactome: R-HSA-6784531;Reactome: R-HSA-9609690;Reactome: R-HSA-5619107;Reactome: R-HSA-9610379;Reactome: R-HSA-4570464;Reactome: R-HSA-4085377;Reactome: R-HSA-3301854;Reactome: R-HSA-180910	"RHO GTPases Activate Formins";"Transport of the SLBP Dependant Mature mRNA";"COPII-mediated vesicle transport";"Transport of the SLBP independent Mature mRNA";"EML4 and NUDC in mitotic spindle formation";"Transport of Mature mRNA Derived from an Intronless Transcript";"Mitotic Prometaphase";"ISG15 antiviral mechanism";"Separation of Sister Chromatids";"NEP/NS2 Interacts with the Cellular Export Machinery";"Viral Messenger RNA Synthesis";"snRNP Assembly";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"SUMOylation of chromatin organization proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"SUMOylation of ubiquitinylation proteins";"Antigen Presentation: Folding, assembly and peptide loading of class I MHC";"Transport of Ribonucleoproteins into the Host Nucleus";"Transcriptional regulation by small RNAs";"Resolution of Sister Chromatid Cohesion";"NS1 Mediated Effects on Host Pathways";"Regulation of HSF1-mediated heat shock response";"SUMOylation of DNA replication proteins";"Nuclear import of Rev protein";"Amino acids regulate mTORC1";"Rev-mediated nuclear export of HIV RNA";"MHC class II antigen presentation";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"SUMOylation of DNA damage response and repair proteins";"tRNA processing in the nucleus";"HCMV Early Events";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"HCMV Late Events";"SUMOylation of RNA binding proteins";"SUMOylation of SUMOylation proteins";"Nuclear Pore Complex (NPC) Disassembly";"Vpr-mediated nuclear import of PICs"
Medex_00027275-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Medex_00014892-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Medex_00086132-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Medex_00033853-RA	1	KEGG: 00970+6.1.1.14	"Aminoacyl-tRNA biosynthesis"
Medex_00013848-RA	2	Reactome: R-HSA-983168;Reactome: R-HSA-8951664	"Antigen processing: Ubiquitination & Proteasome degradation";"Neddylation"
Medex_00083337-RA	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
Medex_00031888-RA	4	MetaCyc: PWY-7219;KEGG: 00230+6.3.4.4;KEGG: 00250+6.3.4.4;Reactome: R-HSA-73817	"Adenosine ribonucleotides de novo biosynthesis";"Purine metabolism";"Alanine, aspartate and glutamate metabolism";"Purine ribonucleoside monophosphate biosynthesis"
Medex_00034597-RA	1	Reactome: R-HSA-1445148	"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
Medex_00064556-RA	3	Reactome: R-HSA-1989781;Reactome: R-HSA-381340;Reactome: R-HSA-212436	"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation";"Generic Transcription Pathway"
Medex_00028407-RA	3	KEGG: 00730+3.1.3.1;MetaCyc: PWY-5491;KEGG: 00790+3.1.3.1	"Thiamine metabolism";"Diethylphosphate degradation";"Folate biosynthesis"
Medex_00042435-RA	8	Reactome: R-HSA-182218;Reactome: R-HSA-167590;Reactome: R-HSA-917977;Reactome: R-HSA-983712;Reactome: R-HSA-77387;Reactome: R-HSA-9639288;Reactome: R-HSA-9636467;Reactome: R-HSA-1222556	"Nef Mediated CD8 Down-regulation";"Nef Mediated CD4 Down-regulation";"Transferrin endocytosis and recycling";"Ion channel transport";"Insulin receptor recycling";"Amino acids regulate mTORC1";"Blockage of phagosome acidification";"ROS and RNS production in phagocytes"
Medex_00061788-RA	1	Reactome: R-HSA-8949664	"Processing of SMDT1"
Medex_00058099-RA	1	Reactome: R-HSA-6809371	"Formation of the cornified envelope"
Medex_00007892-RA	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
Medex_00067101-RA	2	KEGG: 00500+3.2.1.28;Reactome: R-HSA-189085	"Starch and sucrose metabolism";"Digestion of dietary carbohydrate"
Medex_00072919-RA	5	MetaCyc: PWY-7511;Reactome: R-HSA-5358346;Reactome: R-HSA-381038;Reactome: R-HSA-901032;Reactome: R-HSA-5362768	"Protein ubiquitination";"Hedgehog ligand biogenesis";"XBP1(S) activates chaperone genes";"ER Quality Control Compartment (ERQC)";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD"
Medex_00070839-RA	1	KEGG: 00760+2.3.1.286	"Nicotinate and nicotinamide metabolism"
Medex_00027780-RA	3	Reactome: R-HSA-6804760;Reactome: R-HSA-3214858;Reactome: R-HSA-191859	"Regulation of TP53 Activity through Methylation";"RMTs methylate histone arginines";"snRNP Assembly"
Medex_00085291-RA	2	Reactome: R-HSA-8856825;Reactome: R-HSA-8856828	"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis"
Medex_00076349-RA	1	Reactome: R-HSA-6794361	"Neurexins and neuroligins"
Medex_00064183-RA	7	KEGG: 00010+3.1.3.11;Reactome: R-HSA-70263;KEGG: 00051+3.1.3.11;KEGG: 00680+3.1.3.11;KEGG: 00710+3.1.3.11;KEGG: 00030+3.1.3.11;MetaCyc: PWY-5484	"Glycolysis / Gluconeogenesis";"Gluconeogenesis";"Fructose and mannose metabolism";"Methane metabolism";"Carbon fixation in photosynthetic organisms";"Pentose phosphate pathway";"Glycolysis II (from fructose 6-phosphate)"
Medex_00057927-RA	13	KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;Reactome: R-HSA-194840;KEGG: 04151+2.7.11.1;Reactome: R-HSA-193648;Reactome: R-HSA-5687128;Reactome: R-HSA-416476;Reactome: R-HSA-3928662;KEGG: 04714+2.7.11.1;Reactome: R-HSA-416482;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1	"Human cytomegalovirus infection";"Relaxin signaling pathway";"Rho GTPase cycle";"PI3K-Akt signaling pathway";"NRAGE signals death through JNK";"MAPK6/MAPK4 signaling";"G alpha (q) signalling events";"EPHB-mediated forward signaling";"Thermogenesis";"G alpha (12/13) signalling events";"mTOR signaling pathway";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection"
Medex_00047947-RA	26	Reactome: R-HSA-389977;Reactome: R-HSA-68877;Reactome: R-HSA-9648025;Reactome: R-HSA-6811434;Reactome: R-HSA-5617833;Reactome: R-HSA-9646399;Reactome: R-HSA-2467813;Reactome: R-HSA-3371497;Reactome: R-HSA-2500257;Reactome: R-HSA-380320;Reactome: R-HSA-1445148;Reactome: R-HSA-389960;Reactome: R-HSA-5663220;Reactome: R-HSA-8852276;Reactome: R-HSA-9609736;Reactome: R-HSA-983189;Reactome: R-HSA-2132295;Reactome: R-HSA-5626467;Reactome: R-HSA-6811436;Reactome: R-HSA-9609690;Reactome: R-HSA-8955332;Reactome: R-HSA-190840;Reactome: R-HSA-6807878;Reactome: R-HSA-9619483;Reactome: R-HSA-190861;Reactome: R-HSA-437239	"Post-chaperonin tubulin folding pathway";"Mitotic Prometaphase";"EML4 and NUDC in mitotic spindle formation";"COPI-dependent Golgi-to-ER retrograde traffic";"Cilium Assembly";"Aggrephagy";"Separation of Sister Chromatids";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Resolution of Sister Chromatid Cohesion";"Recruitment of NuMA to mitotic centrosomes";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Formation of tubulin folding intermediates by CCT/TriC";"RHO GTPases Activate Formins";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Assembly and cell surface presentation of NMDA receptors";"Kinesins";"MHC class II antigen presentation";"RHO GTPases activate IQGAPs";"COPI-independent Golgi-to-ER retrograde traffic";"HCMV Early Events";"Carboxyterminal post-translational modifications of tubulin";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"COPI-mediated anterograde transport";"Activation of AMPK downstream of NMDARs";"Gap junction assembly";"Recycling pathway of L1"
Medex_00034425-RA	5	Reactome: R-HSA-917977;Reactome: R-HSA-983712;Reactome: R-HSA-77387;Reactome: R-HSA-9639288;Reactome: R-HSA-1222556	"Transferrin endocytosis and recycling";"Ion channel transport";"Insulin receptor recycling";"Amino acids regulate mTORC1";"ROS and RNS production in phagocytes"
Medex_00004909-RA	2	Reactome: R-HSA-390471;Reactome: R-HSA-1660662	"Association of TriC/CCT with target proteins during biosynthesis";"Glycosphingolipid metabolism"
Medex_00091382-RA	15	MetaCyc: PWY-8004;KEGG: 00010+2.7.1.40;MetaCyc: PWY-7218;MetaCyc: PWY-5484;MetaCyc: PWY-7383;MetaCyc: PWY-2221;KEGG: 00230+2.7.1.40;Reactome: R-HSA-70171;MetaCyc: PWY-6886;MetaCyc: PWY-5723;MetaCyc: PWY-1042;MetaCyc: PWY-7003;MetaCyc: PWY-6901;KEGG: 00620+2.7.1.40;MetaCyc: PWY-6142	"Entner-Doudoroff pathway I";"Glycolysis / Gluconeogenesis";"Photosynthetic 3-hydroxybutanoate biosynthesis (engineered)";"Glycolysis II (from fructose 6-phosphate)";"Anaerobic energy metabolism (invertebrates, cytosol)";"Entner-Doudoroff pathway III (semi-phosphorylative)";"Purine metabolism";"Glycolysis";"1-butanol autotrophic biosynthesis (engineered)";"Rubisco shunt";"Glycolysis IV (plant cytosol)";"Glycerol degradation to butanol";"Superpathway of glucose and xylose degradation";"Pyruvate metabolism";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)"
Medex_00088814-RA	3	Reactome: R-HSA-110312;Reactome: R-HSA-5655862;Reactome: R-HSA-5656121	"Translesion synthesis by REV1";"Translesion synthesis by POLK";"Translesion synthesis by POLI"
Medex_00034271-RA	3	Reactome: R-HSA-3000157;Reactome: R-HSA-8874081;Reactome: R-HSA-3000171	"Laminin interactions";"MET activates PTK2 signaling";"Non-integrin membrane-ECM interactions"
Medex_00062568-RA	5	Reactome: R-HSA-6782135;Reactome: R-HSA-6781823;Reactome: R-HSA-6781827;Reactome: R-HSA-72163;Reactome: R-HSA-6782210	"Dual incision in TC-NER";"Formation of TC-NER Pre-Incision Complex";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"mRNA Splicing - Major Pathway";"Gap-filling DNA repair synthesis and ligation in TC-NER"
Medex_00013024-RA	1	KEGG: 00480+3.4.11.2	"Glutathione metabolism"
Medex_00004974-RA	1	Reactome: R-HSA-426117	"Cation-coupled Chloride cotransporters"
Medex_00075148-RA	2	Reactome: R-HSA-195399;Reactome: R-HSA-9013695	"VEGF binds to VEGFR leading to receptor dimerization";"NOTCH4 Intracellular Domain Regulates Transcription"
Medex_00026920-RA	1	KEGG: 00970+6.1.1.7	"Aminoacyl-tRNA biosynthesis"
Medex_00061379-RA	10	KEGG: 00052+3.2.1.23;KEGG: 00531+3.2.1.23;Reactome: R-HSA-6798695;KEGG: 00600+3.2.1.23;Reactome: R-HSA-2160916;Reactome: R-HSA-2206292;Reactome: R-HSA-2024096;MetaCyc: PWY-6807;KEGG: 00511+3.2.1.23;KEGG: 00604+3.2.1.23	"Galactose metabolism";"Glycosaminoglycan degradation";"Neutrophil degranulation";"Sphingolipid metabolism";"Hyaluronan uptake and degradation";"MPS VII - Sly syndrome";"HS-GAG degradation";"Xyloglucan degradation II (exoglucanase)";"Other glycan degradation";"Glycosphingolipid biosynthesis - ganglio series"
Medex_00063306-RA	1	Reactome: R-HSA-1799339	"SRP-dependent cotranslational protein targeting to membrane"
Medex_00025618-RA	1	Reactome: R-HSA-8951664	"Neddylation"
Medex_00023992-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Medex_00022560-RA	1	Reactome: R-HSA-1632852	"Macroautophagy"
Medex_00013125-RA	2	MetaCyc: PWY-6981;KEGG: 00520+2.4.1.16	"Chitin biosynthesis";"Amino sugar and nucleotide sugar metabolism"
Medex_00035480-RA	4	Reactome: R-HSA-947581;KEGG: 00790+2.8.1.12;MetaCyc: PWY-6823;MetaCyc: PWY-7887	"Molybdenum cofactor biosynthesis";"Folate biosynthesis";"Molybdenum cofactor biosynthesis";"Protein SAMPylation and SAMP-mediated thiolation"
Medex_00007630-RA	11	Reactome: R-HSA-72163;Reactome: R-HSA-2644606;Reactome: R-HSA-2122947;Reactome: R-HSA-9013695;Reactome: R-HSA-210744;Reactome: R-HSA-8941856;Reactome: R-HSA-350054;Reactome: R-HSA-1912408;Reactome: R-HSA-2894862;Reactome: R-HSA-9013508;Reactome: R-HSA-2173796	"mRNA Splicing - Major Pathway";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH1 Intracellular Domain Regulates Transcription";"NOTCH4 Intracellular Domain Regulates Transcription";"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"RUNX3 regulates NOTCH signaling";"Notch-HLH transcription pathway";"Pre-NOTCH Transcription and Translation";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"NOTCH3 Intracellular Domain Regulates Transcription";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription"
Medex_00023291-RA	2	Reactome: R-HSA-72706;Reactome: R-HSA-72702	"GTP hydrolysis and joining of the 60S ribosomal subunit";"Ribosomal scanning and start codon recognition"
Medex_00046568-RA	2	Reactome: R-HSA-3238698;Reactome: R-HSA-373080	"WNT ligand biogenesis and trafficking";"Class B/2 (Secretin family receptors)"
Medex_00005726-RA	9	Reactome: R-HSA-167172;Reactome: R-HSA-167161;Reactome: R-HSA-75953;Reactome: R-HSA-73776;Reactome: R-HSA-6807505;Reactome: R-HSA-674695;Reactome: R-HSA-73779;Reactome: R-HSA-76042;Reactome: R-HSA-167162	"Transcription of the HIV genome";"HIV Transcription Initiation";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Promoter Escape";"RNA polymerase II transcribes snRNA genes";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II HIV Promoter Escape"
Medex_00028763-RA	3	KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway"
Medex_00039238-RA	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5419276;Reactome: R-HSA-5368286	"Mitochondrial translation elongation";"Mitochondrial translation termination";"Mitochondrial translation initiation"
Medex_00042428-RA	4	Reactome: R-HSA-68884;Reactome: R-HSA-983189;Reactome: R-HSA-2132295;Reactome: R-HSA-6811434	"Mitotic Telophase/Cytokinesis";"Kinesins";"MHC class II antigen presentation";"COPI-dependent Golgi-to-ER retrograde traffic"
Medex_00017050-RA	6	MetaCyc: PWY-5884;Reactome: R-HSA-9640463;MetaCyc: PWY-7782;MetaCyc: PWY-7656;MetaCyc: PWY-6733;KEGG: 00073+1.2.1.84	"Wax esters biosynthesis I";"Wax biosynthesis";"Plasmalogen biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Sporopollenin precursors biosynthesis";"Cutin, suberine and wax biosynthesis"
Medex_00011493-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00029192-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00081933-RA	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
Medex_00024987-RA	14	KEGG: 00565+3.1.3.4;MetaCyc: PWY-8055;KEGG: 00564+3.1.3.4;MetaCyc: PWY-7782;KEGG: 00600+3.1.3.4;Reactome: R-HSA-1483213;MetaCyc: PWY-8053;Reactome: R-HSA-1483191;MetaCyc: PWY-8052;Reactome: R-HSA-4419969;Reactome: R-HSA-75109;KEGG: 00561+3.1.3.4;MetaCyc: PWY-6453;MetaCyc: PWY-8051	"Ether lipid metabolism";"Palmitoyl ethanolamide biosynthesis";"Glycerophospholipid metabolism";"Plasmalogen biosynthesis";"Sphingolipid metabolism";"Synthesis of PE";"Anandamide biosynthesis II";"Synthesis of PC";"2-arachidonoylglycerol biosynthesis";"Depolymerisation of the Nuclear Lamina";"Triglyceride biosynthesis";"Glycerolipid metabolism";"Stigma estolide biosynthesis";"Anandamide biosynthesis I"
Medex_00064577-RA	2	Reactome: R-HSA-72165;Reactome: R-HSA-72163	"mRNA Splicing - Minor Pathway";"mRNA Splicing - Major Pathway"
Medex_00007751-RA	6	MetaCyc: PWY-5789;Reactome: R-HSA-196780;MetaCyc: PWY-5744;MetaCyc: PWY-6722;MetaCyc: PWY-5743;MetaCyc: PWY-4381	"3-hydroxypropanoate/4-hydroxybutanate cycle";"Biotin transport and metabolism";"Glyoxylate assimilation";"Candicidin biosynthesis";"3-hydroxypropanoate cycle";"Fatty acid biosynthesis initiation (bacteria and plants)"
Medex_00004356-RA	4	Reactome: R-HSA-3000171;Reactome: R-HSA-3000178;Reactome: R-HSA-3000157;Reactome: R-HSA-8874081	"Non-integrin membrane-ECM interactions";"ECM proteoglycans";"Laminin interactions";"MET activates PTK2 signaling"
Medex_00060965-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Medex_00025055-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Medex_00004914-RA	1	KEGG: 00970+6.1.1.20	"Aminoacyl-tRNA biosynthesis"
Medex_00084909-RA	2	Reactome: R-HSA-3214858;Reactome: R-HSA-8939243	"RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"
Medex_00008357-RA	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
Medex_00059275-RA	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
Medex_00093543-RA	1	Reactome: R-HSA-6802952	"Signaling by BRAF and RAF fusions"
Medex_00067599-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00041287-RA	3	MetaCyc: PWY-6689;Reactome: R-HSA-6784531;MetaCyc: PWY-7803	"Trna splicing I";"tRNA processing in the nucleus";"Trna splicing II"
Medex_00060492-RA	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
Medex_00040518-RA	3	Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-212436	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"Generic Transcription Pathway"
Medex_00088139-RA	2	Reactome: R-HSA-6811434;Reactome: R-HSA-6807878	"COPI-dependent Golgi-to-ER retrograde traffic";"COPI-mediated anterograde transport"
Medex_00031173-RA	1	Reactome: R-HSA-71384	"Ethanol oxidation"
Medex_00051381-RA	1	Reactome: R-HSA-3214858	"RMTs methylate histone arginines"
Medex_00000079-RA	1	KEGG: 00480+3.4.11.2	"Glutathione metabolism"
Medex_00079456-RA	3	Reactome: R-HSA-6798695;Reactome: R-HSA-9609523;Reactome: R-HSA-1660661	"Neutrophil degranulation";"Insertion of tail-anchored proteins into the endoplasmic reticulum membrane";"Sphingolipid de novo biosynthesis"
Medex_00010605-RA	1	Reactome: R-HSA-380320	"Recruitment of NuMA to mitotic centrosomes"
Medex_00078092-RA	1	Reactome: R-HSA-425381	"Bicarbonate transporters"
Medex_00016317-RA	2	Reactome: R-HSA-390471;Reactome: R-HSA-1660662	"Association of TriC/CCT with target proteins during biosynthesis";"Glycosphingolipid metabolism"
Medex_00007169-RA	2	Reactome: R-HSA-1660662;Reactome: R-HSA-390471	"Glycosphingolipid metabolism";"Association of TriC/CCT with target proteins during biosynthesis"
Medex_00028528-RA	1	Reactome: R-HSA-216083	"Integrin cell surface interactions"
Medex_00028236-RA	2	Reactome: R-HSA-6783310;Reactome: R-HSA-6796648	"Fanconi Anemia Pathway";"TP53 Regulates Transcription of DNA Repair Genes"
Medex_00009118-RA	1	Reactome: R-HSA-6784531	"tRNA processing in the nucleus"
Medex_00046835-RA	3	Reactome: R-HSA-382556;Reactome: R-HSA-1989781;Reactome: R-HSA-5678771	"ABC-family proteins mediated transport";"PPARA activates gene expression";"Defective ABCB4 causes progressive familial intrahepatic cholestasis 3, intrahepatic cholestasis of pregnancy 3 and gallbladder disease 1"
Medex_00022158-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Medex_00010409-RA	2	Reactome: R-HSA-196807;KEGG: 00760+6.3.1.5	"Nicotinate metabolism";"Nicotinate and nicotinamide metabolism"
Medex_00085531-RA	1	Reactome: R-HSA-425561	"Sodium/Calcium exchangers"
Medex_00034209-RA	1	Reactome: R-HSA-5656169	"Termination of translesion DNA synthesis"
Medex_00084761-RA	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
Medex_00050899-RA	5	Reactome: R-HSA-937041;Reactome: R-HSA-166166;Reactome: R-HSA-168164;Reactome: R-HSA-936964;Reactome: R-HSA-937072	"IKK complex recruitment mediated by RIP1";"MyD88-independent TLR4 cascade";"Toll Like Receptor 3 (TLR3) Cascade";"Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon";"TRAF6-mediated induction of TAK1 complex within TLR4 complex"
Medex_00004262-RA	1	Reactome: R-HSA-429958	"mRNA decay by 3' to 5' exoribonuclease"
Medex_00021528-RA	2	MetaCyc: PWY-7511;Reactome: R-HSA-8866654	"Protein ubiquitination";"E3 ubiquitin ligases ubiquitinate target proteins"
Medex_00072480-RA	1	Reactome: R-HSA-2995383	"Initiation of Nuclear Envelope Reformation"
Medex_00033680-RA	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00008609-RA	2	Reactome: R-HSA-1222556;Reactome: R-HSA-392154	"ROS and RNS production in phagocytes";"Nitric oxide stimulates guanylate cyclase"
Medex_00009681-RA	3	KEGG: 00970+6.1.1.5;Reactome: R-HSA-379716;Reactome: R-HSA-2408522	"Aminoacyl-tRNA biosynthesis";"Cytosolic tRNA aminoacylation";"Selenoamino acid metabolism"
Medex_00060981-RA	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
Medex_00009057-RA	2	Reactome: R-HSA-8939243;Reactome: R-HSA-3214858	"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RMTs methylate histone arginines"
Medex_00076234-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Medex_00038362-RA	1	Reactome: R-HSA-418594	"G alpha (i) signalling events"
Medex_00047374-RA	5	Reactome: R-HSA-72165;Reactome: R-HSA-159236;Reactome: R-HSA-72163;Reactome: R-HSA-72187;Reactome: R-HSA-73856	"mRNA Splicing - Minor Pathway";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"mRNA Splicing - Major Pathway";"mRNA 3'-end processing";"RNA Polymerase II Transcription Termination"
Medex_00042850-RA	10	Reactome: R-HSA-8856825;Reactome: R-HSA-182971;Reactome: R-HSA-8875360;Reactome: R-HSA-6807004;Reactome: R-HSA-9636383;Reactome: R-HSA-9635644;Reactome: R-HSA-5689880;Reactome: R-HSA-8856828;Reactome: R-HSA-917729;Reactome: R-HSA-432720	"Cargo recognition for clathrin-mediated endocytosis";"EGFR downregulation";"InlB-mediated entry of Listeria monocytogenes into host cell";"Negative regulation of MET activity";"Prevention of phagosomal-lysosomal fusion";"Inhibition of membrane repair";"Ub-specific processing proteases";"Clathrin-mediated endocytosis";"Endosomal Sorting Complex Required For Transport (ESCRT)";"Lysosome Vesicle Biogenesis"
Medex_00061880-RA	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
Medex_00078844-RA	5	KEGG: 00020+1.2.4.2;Reactome: R-HSA-389661;KEGG: 00380+1.2.4.2;KEGG: 00310+1.2.4.2;MetaCyc: PWY-5084	"Citrate cycle (TCA cycle)";"Glyoxylate metabolism and glycine degradation";"Tryptophan metabolism";"Lysine degradation";"2-oxoglutarate decarboxylation to succinyl-CoA"
Medex_00066992-RA	5	Reactome: R-HSA-6811436;Reactome: R-HSA-6807878;Reactome: R-HSA-6798695;Reactome: R-HSA-3371497;Reactome: R-HSA-2132295	"COPI-independent Golgi-to-ER retrograde traffic";"COPI-mediated anterograde transport";"Neutrophil degranulation";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"MHC class II antigen presentation"
Medex_00004106-RA	4	Reactome: R-HSA-1296025;Reactome: R-HSA-5678420;Reactome: R-HSA-5578775;Reactome: R-HSA-382556	"ATP sensitive Potassium channels";"Defective ABCC9 causes dilated cardiomyopathy 10, familial atrial fibrillation 12 and hypertrichotic osteochondrodysplasia";"Ion homeostasis";"ABC-family proteins mediated transport"
Medex_00076853-RA	1	Reactome: R-HSA-3214842	"HDMs demethylate histones"
Medex_00008782-RA	3	Reactome: R-HSA-212436;Reactome: R-HSA-1989781;Reactome: R-HSA-381340	"Generic Transcription Pathway";"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation"
Medex_00060531-RA	1	Reactome: R-HSA-400253	"Circadian Clock"
Medex_00031559-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Medex_00076161-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Medex_00065163-RA	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5419276;Reactome: R-HSA-5389840	"Mitochondrial translation initiation";"Mitochondrial translation termination";"Mitochondrial translation elongation"
Medex_00041681-RA	1	Reactome: R-HSA-9603798	"Class I peroxisomal membrane protein import"
Medex_00000062-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Medex_00040440-RA	1	Reactome: R-HSA-111465	"Apoptotic cleavage of cellular proteins"
Medex_00014288-RA	2	Reactome: R-HSA-375276;Reactome: R-HSA-416476	"Peptide ligand-binding receptors";"G alpha (q) signalling events"
Medex_00089472-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00087799-RA	13	Reactome: R-HSA-72689;Reactome: R-HSA-72764;Reactome: R-HSA-975956;Reactome: R-HSA-72706;Reactome: R-HSA-6791226;Reactome: R-HSA-2408557;Reactome: R-HSA-192823;Reactome: R-HSA-975957;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-9633012;Reactome: R-HSA-156902;Reactome: R-HSA-1799339	"Formation of a pool of free 40S subunits";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Major pathway of rRNA processing in the nucleolus and cytosol";"Selenocysteine synthesis";"Viral mRNA Translation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Peptide chain elongation";"SRP-dependent cotranslational protein targeting to membrane"
Medex_00008643-RA	7	Reactome: R-HSA-3214841;Reactome: R-HSA-212300;Reactome: R-HSA-8943724;Reactome: R-HSA-9609690;Reactome: R-HSA-5617472;Reactome: R-HSA-8953750;Reactome: R-HSA-2559580	"PKMTs methylate histone lysines";"PRC2 methylates histones and DNA";"Regulation of PTEN gene transcription";"HCMV Early Events";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Transcriptional Regulation by E2F6";"Oxidative Stress Induced Senescence"
Medex_00016322-RA	19	Reactome: R-HSA-8963901;Reactome: R-HSA-3000480;Reactome: R-HSA-8856828;Reactome: R-HSA-8964041;Reactome: R-HSA-8963888;Reactome: R-HSA-975634;Reactome: R-HSA-381426;Reactome: R-HSA-3000471;Reactome: R-HSA-202733;Reactome: R-HSA-3000497;Reactome: R-HSA-8957275;Reactome: R-HSA-8964038;Reactome: R-HSA-8964046;Reactome: R-HSA-432142;Reactome: R-HSA-8866423;Reactome: R-HSA-3000484;Reactome: R-HSA-5686938;Reactome: R-HSA-8964026;Reactome: R-HSA-8856825	"Chylomicron remodeling";"Scavenging by Class A Receptors";"Clathrin-mediated endocytosis";"LDL remodeling";"Chylomicron assembly";"Retinoid metabolism and transport";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"Scavenging by Class B Receptors";"Cell surface interactions at the vascular wall";"Scavenging by Class H Receptors";"Post-translational protein phosphorylation";"LDL clearance";"VLDL clearance";"Platelet sensitization by LDL";"VLDL assembly";"Scavenging by Class F Receptors";"Regulation of TLR by endogenous ligand";"Chylomicron clearance";"Cargo recognition for clathrin-mediated endocytosis"
Medex_00069391-RA	1	Reactome: R-HSA-9033241	"Peroxisomal protein import"
Medex_00012727-RA	3	Reactome: R-HSA-6798695;MetaCyc: PWY-6807;KEGG: 00511+3.2.1.51	"Neutrophil degranulation";"Xyloglucan degradation II (exoglucanase)";"Other glycan degradation"
Medex_00069731-RA	13	Reactome: R-HSA-2160916;KEGG: 00531+3.2.1.52;KEGG: 00520+3.2.1.52;KEGG: 00603+3.2.1.52;MetaCyc: PWY-6902;MetaCyc: PWY-7883;KEGG: 00604+3.2.1.52;Reactome: R-HSA-1660662;Reactome: R-HSA-2024101;MetaCyc: PWY-7822;KEGG: 00513+3.2.1.52;KEGG: 00511+3.2.1.52;Reactome: R-HSA-2022857	"Hyaluronan uptake and degradation";"Glycosaminoglycan degradation";"Amino sugar and nucleotide sugar metabolism";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Chitin degradation II (Vibrio)";"Anhydromuropeptides recycling II";"Glycosphingolipid biosynthesis - ganglio series";"Glycosphingolipid metabolism";"CS/DS degradation";"Chitin degradation III (Serratia)";"Various types of N-glycan biosynthesis";"Other glycan degradation";"Keratan sulfate degradation"
Medex_00023950-RA	18	KEGG: 00950+2.6.1.1;KEGG: 00330+2.6.1.1;KEGG: 00960+2.6.1.1;KEGG: 00400+2.6.1.1;KEGG: 00401+2.6.1.1;MetaCyc: PWY-7117;KEGG: 00710+2.6.1.1;KEGG: 00250+2.6.1.1;MetaCyc: PWY-6643;MetaCyc: PWY-5913;KEGG: 00270+2.6.1.1;KEGG: 00220+2.6.1.1;KEGG: 00350+2.6.1.1;KEGG: 00360+2.6.1.1;MetaCyc: PWY-6642;MetaCyc: PWY-7115;MetaCyc: PWY-7383;MetaCyc: PWY-6638	"Isoquinoline alkaloid biosynthesis";"Arginine and proline metabolism";"Tropane, piperidine and pyridine alkaloid biosynthesis";"Phenylalanine, tyrosine and tryptophan biosynthesis";"Novobiocin biosynthesis";"C4 photosynthetic carbon assimilation cycle, PEPCK type";"Carbon fixation in photosynthetic organisms";"Alanine, aspartate and glutamate metabolism";"Coenzyme M biosynthesis II";"Partial TCA cycle (obligate autotrophs)";"Cysteine and methionine metabolism";"Arginine biosynthesis";"Tyrosine metabolism";"Phenylalanine metabolism";"(R)-cysteate degradation";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"Anaerobic energy metabolism (invertebrates, cytosol)";"Sulfolactate degradation III"
Medex_00078271-RA	3	Reactome: R-HSA-3232118;Reactome: R-HSA-4090294;Reactome: R-HSA-3899300	"SUMOylation of transcription factors";"SUMOylation of intracellular receptors";"SUMOylation of transcription cofactors"
Medex_00079618-RA	15	Reactome: R-HSA-8853884;Reactome: R-HSA-176409;Reactome: R-HSA-174154;Reactome: R-HSA-2467813;Reactome: R-HSA-179409;Reactome: R-HSA-174184;Reactome: R-HSA-174178;Reactome: R-HSA-176412;Reactome: R-HSA-141430;Reactome: R-HSA-176407;Reactome: R-HSA-174048;Reactome: R-HSA-176408;Reactome: R-HSA-69017;Reactome: R-HSA-2559582;Reactome: R-HSA-174084	"Transcriptional Regulation by VENTX";"APC/C:Cdc20 mediated degradation of mitotic proteins";"APC/C:Cdc20 mediated degradation of Securin";"Separation of Sister Chromatids";"APC-Cdc20 mediated degradation of Nek2A";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Phosphorylation of the APC/C";"Inactivation of APC/C via direct inhibition of the APC/C complex";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"APC/C:Cdc20 mediated degradation of Cyclin B";"Regulation of APC/C activators between G1/S and early anaphase";"CDK-mediated phosphorylation and removal of Cdc6";"Senescence-Associated Secretory Phenotype (SASP)";"Autodegradation of Cdh1 by Cdh1:APC/C"
Medex_00077416-RA	4	Reactome: R-HSA-382556;MetaCyc: PWY-6972;Reactome: R-HSA-5679001;Reactome: R-HSA-189483	"ABC-family proteins mediated transport";"Oleandomycin activation/inactivation";"Defective ABCC2 causes Dubin-Johnson syndrome";"Heme degradation"
Medex_00093331-RA	3	Reactome: R-HSA-674695;Reactome: R-HSA-112382;Reactome: R-HSA-75955	"RNA Polymerase II Pre-transcription Events";"Formation of RNA Pol II elongation complex";"RNA Polymerase II Transcription Elongation"
Medex_00073037-RA	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00062510-RA	2	Reactome: R-HSA-8939243;Reactome: R-HSA-3214858	"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RMTs methylate histone arginines"
Medex_00046902-RA	1	Reactome: R-HSA-156584	"Cytosolic sulfonation of small molecules"
Medex_00071837-RA	4	KEGG: 00310+1.2.4.2;MetaCyc: PWY-5084;KEGG: 00380+1.2.4.2;KEGG: 00020+1.2.4.2	"Lysine degradation";"2-oxoglutarate decarboxylation to succinyl-CoA";"Tryptophan metabolism";"Citrate cycle (TCA cycle)"
Medex_00044279-RA	10	Reactome: R-HSA-72702;Reactome: R-HSA-381042;Reactome: R-HSA-72731;Reactome: R-HSA-72706;Reactome: R-HSA-72649;Reactome: R-HSA-9633012;Reactome: R-HSA-72695;Reactome: R-HSA-382556;Reactome: R-HSA-156827;Reactome: R-HSA-9648895	"Ribosomal scanning and start codon recognition";"PERK regulates gene expression";"Recycling of eIF2:GDP";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Translation initiation complex formation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Formation of the ternary complex, and subsequently, the 43S complex";"ABC-family proteins mediated transport";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK1 (HRI) to heme deficiency"
Medex_00016356-RA	2	Reactome: R-HSA-6807878;Reactome: R-HSA-6811434	"COPI-mediated anterograde transport";"COPI-dependent Golgi-to-ER retrograde traffic"
Medex_00043746-RA	57	Reactome: R-HSA-1169091;Reactome: R-HSA-174154;Reactome: R-HSA-174184;Reactome: R-HSA-5607764;Reactome: R-HSA-8951664;Reactome: R-HSA-2871837;Reactome: R-HSA-350562;Reactome: R-HSA-5678895;Reactome: R-HSA-69481;Reactome: R-HSA-174113;Reactome: R-HSA-4641257;Reactome: R-HSA-5362768;Reactome: R-HSA-1234176;Reactome: R-HSA-69601;Reactome: R-HSA-69017;Reactome: R-HSA-5676590;Reactome: R-HSA-8948751;Reactome: R-HSA-68827;Reactome: R-HSA-9604323;Reactome: R-HSA-5610783;Reactome: R-HSA-1236974;Reactome: R-HSA-8854050;Reactome: R-HSA-187577;Reactome: R-HSA-174084;Reactome: R-HSA-5632684;Reactome: R-HSA-1236978;Reactome: R-HSA-349425;Reactome: R-HSA-180534;Reactome: R-HSA-5607761;Reactome: R-HSA-5610780;Reactome: R-HSA-8852276;Reactome: R-HSA-174178;Reactome: R-HSA-8939902;Reactome: R-HSA-75815;Reactome: R-HSA-195253;Reactome: R-HSA-5689880;Reactome: R-HSA-5610785;Reactome: R-HSA-5689603;Reactome: R-HSA-5668541;Reactome: R-HSA-5687128;Reactome: R-HSA-4608870;Reactome: R-HSA-4641258;Reactome: R-HSA-2467813;Reactome: R-HSA-180585;Reactome: R-HSA-450408;Reactome: R-HSA-9010553;Reactome: R-HSA-68949;Reactome: R-HSA-382556;Reactome: R-HSA-8939236;Reactome: R-HSA-211733;Reactome: R-HSA-5658442;Reactome: R-HSA-5358346;Reactome: R-HSA-8941858;Reactome: R-HSA-983168;Reactome: R-HSA-202424;Reactome: R-HSA-9020702;Reactome: R-HSA-6798695	"Activation of NF-kappaB in B cells";"APC/C:Cdc20 mediated degradation of Securin";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"CLEC7A (Dectin-1) signaling";"Neddylation";"FCERI mediated NF-kB activation";"Regulation of ornithine decarboxylase (ODC)";"Defective CFTR causes cystic fibrosis";"G2/M Checkpoints";"SCF-beta-TrCP mediated degradation of Emi1";"Degradation of AXIN";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"CDK-mediated phosphorylation and removal of Cdc6";"NIK-->noncanonical NF-kB signaling";"Regulation of PTEN stability and activity";"CDT1 association with the CDC6:ORC:origin complex";"Negative regulation of NOTCH4 signaling";"Degradation of GLI2 by the proteasome";"ER-Phagosome pathway";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"SCF(Skp2)-mediated degradation of p27/p21";"Autodegradation of Cdh1 by Cdh1:APC/C";"Hedgehog 'on' state";"Cross-presentation of soluble exogenous antigens (endosomes)";"Autodegradation of the E3 ubiquitin ligase COP1";"Vpu mediated degradation of CD4";"Dectin-1 mediated noncanonical NF-kB signaling";"Degradation of GLI1 by the proteasome";"The role of GTSE1 in G2/M progression after G2 checkpoint";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Regulation of RUNX2 expression and activity";"Ubiquitin-dependent degradation of Cyclin D";"Degradation of beta-catenin by the destruction complex";"Ub-specific processing proteases";"GLI3 is processed to GLI3R by the proteasome";"UCH proteinases";"TNFR2 non-canonical NF-kB pathway";"MAPK6/MAPK4 signaling";"Asymmetric localization of PCP proteins";"Degradation of DVL";"Separation of Sister Chromatids";"Vif-mediated degradation of APOBEC3G";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Regulation of expression of SLITs and ROBOs";"Orc1 removal from chromatin";"ABC-family proteins mediated transport";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Regulation of RAS by GAPs";"Hedgehog ligand biogenesis";"Regulation of RUNX3 expression and activity";"Antigen processing: Ubiquitination & Proteasome degradation";"Downstream TCR signaling";"Interleukin-1 signaling";"Neutrophil degranulation"
Medex_00096266-RA	3	Reactome: R-HSA-418594;Reactome: R-HSA-375276;Reactome: R-HSA-416476	"G alpha (i) signalling events";"Peptide ligand-binding receptors";"G alpha (q) signalling events"
Medex_00092968-RA	1	Reactome: R-HSA-380320	"Recruitment of NuMA to mitotic centrosomes"
Medex_00014251-RA	1	Reactome: R-HSA-2129379	"Molecules associated with elastic fibres"
Medex_00075261-RA	2	Reactome: R-HSA-204005;Reactome: R-HSA-8876198	"COPII-mediated vesicle transport";"RAB GEFs exchange GTP for GDP on RABs"
Medex_00063046-RA	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
Medex_00077633-RA	1	Reactome: R-HSA-6784531	"tRNA processing in the nucleus"
Medex_00067259-RA	13	KEGG: 00240+1.17.4.1;MetaCyc: PWY-7210;KEGG: 00983+1.17.4.1;MetaCyc: PWY-7198;Reactome: R-HSA-499943;MetaCyc: PWY-7227;MetaCyc: PWY-7226;KEGG: 00230+1.17.4.1;MetaCyc: PWY-7222;MetaCyc: PWY-6545;KEGG: 00480+1.17.4.1;MetaCyc: PWY-7220;MetaCyc: PWY-7184	"Pyrimidine metabolism";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Drug metabolism - other enzymes";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Interconversion of nucleotide di- and triphosphates";"Adenosine deoxyribonucleotides de novo biosynthesis";"Guanosine deoxyribonucleotides de novo biosynthesis I";"Purine metabolism";"Guanosine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Glutathione metabolism";"Adenosine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotides de novo biosynthesis I"
Medex_00009417-RA	3	Reactome: R-HSA-913709;Reactome: R-HSA-2022854;Reactome: R-HSA-975577	"O-linked glycosylation of mucins";"Keratan sulfate biosynthesis";"N-Glycan antennae elongation"
Medex_00028695-RA	6	Reactome: R-HSA-5617472;Reactome: R-HSA-8951664;Reactome: R-HSA-3769402;Reactome: R-HSA-3214841;Reactome: R-HSA-8936459;Reactome: R-HSA-201722	"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Neddylation";"Deactivation of the beta-catenin transactivating complex";"PKMTs methylate histone lysines";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Formation of the beta-catenin:TCF transactivating complex"
Medex_00084850-RA	32	Reactome: R-HSA-75955;Reactome: R-HSA-9018519;Reactome: R-HSA-167246;Reactome: R-HSA-167160;Reactome: R-HSA-167200;Reactome: R-HSA-72163;Reactome: R-HSA-167172;Reactome: R-HSA-167290;Reactome: R-HSA-167242;Reactome: R-HSA-112382;Reactome: R-HSA-73779;Reactome: R-HSA-8851708;Reactome: R-HSA-167161;Reactome: R-HSA-75953;Reactome: R-HSA-6807505;Reactome: R-HSA-113418;Reactome: R-HSA-167162;Reactome: R-HSA-76042;Reactome: R-HSA-72165;Reactome: R-HSA-167152;Reactome: R-HSA-674695;Reactome: R-HSA-73776;Reactome: R-HSA-167243;Reactome: R-HSA-167287;Reactome: R-HSA-167238;Reactome: R-HSA-6796648;Reactome: R-HSA-72086;Reactome: R-HSA-72203;Reactome: R-HSA-168325;Reactome: R-HSA-77075;Reactome: R-HSA-167158;Reactome: R-HSA-6803529	"RNA Polymerase II Transcription Elongation";"Estrogen-dependent gene expression";"Tat-mediated elongation of the HIV-1 transcript";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"mRNA Splicing - Major Pathway";"Transcription of the HIV genome";"Pausing and recovery of HIV elongation";"Abortive elongation of HIV-1 transcript in the absence of Tat";"Formation of RNA Pol II elongation complex";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Signaling by FGFR2 IIIa TM";"HIV Transcription Initiation";"RNA Polymerase II Transcription Initiation";"RNA polymerase II transcribes snRNA genes";"Formation of the Early Elongation Complex";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"mRNA Splicing - Minor Pathway";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Promoter Escape";"Tat-mediated HIV elongation arrest and recovery";"HIV elongation arrest and recovery";"Pausing and recovery of Tat-mediated HIV elongation";"TP53 Regulates Transcription of DNA Repair Genes";"mRNA Capping";"Processing of Capped Intron-Containing Pre-mRNA";"Viral Messenger RNA Synthesis";"RNA Pol II CTD phosphorylation and interaction with CE";"Formation of the HIV-1 Early Elongation Complex";"FGFR2 alternative splicing"
Medex_00018184-RA	26	Reactome: R-HSA-2467813;Reactome: R-HSA-9646399;Reactome: R-HSA-5617833;Reactome: R-HSA-6811434;Reactome: R-HSA-9648025;Reactome: R-HSA-68877;Reactome: R-HSA-389977;Reactome: R-HSA-5663220;Reactome: R-HSA-1445148;Reactome: R-HSA-389960;Reactome: R-HSA-380320;Reactome: R-HSA-2500257;Reactome: R-HSA-3371497;Reactome: R-HSA-983189;Reactome: R-HSA-9609736;Reactome: R-HSA-8852276;Reactome: R-HSA-190840;Reactome: R-HSA-6807878;Reactome: R-HSA-190861;Reactome: R-HSA-437239;Reactome: R-HSA-9619483;Reactome: R-HSA-8955332;Reactome: R-HSA-9609690;Reactome: R-HSA-6811436;Reactome: R-HSA-5626467;Reactome: R-HSA-2132295	"Separation of Sister Chromatids";"Aggrephagy";"Cilium Assembly";"COPI-dependent Golgi-to-ER retrograde traffic";"EML4 and NUDC in mitotic spindle formation";"Mitotic Prometaphase";"Post-chaperonin tubulin folding pathway";"RHO GTPases Activate Formins";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Formation of tubulin folding intermediates by CCT/TriC";"Recruitment of NuMA to mitotic centrosomes";"Resolution of Sister Chromatid Cohesion";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Kinesins";"Assembly and cell surface presentation of NMDA receptors";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"COPI-mediated anterograde transport";"Gap junction assembly";"Recycling pathway of L1";"Activation of AMPK downstream of NMDARs";"Carboxyterminal post-translational modifications of tubulin";"HCMV Early Events";"COPI-independent Golgi-to-ER retrograde traffic";"RHO GTPases activate IQGAPs";"MHC class II antigen presentation"
Medex_00052301-RA	4	Reactome: R-HSA-499943;MetaCyc: PWY-7219;KEGG: 00230+2.7.4.3;KEGG: 00730+2.7.4.3	"Interconversion of nucleotide di- and triphosphates";"Adenosine ribonucleotides de novo biosynthesis";"Purine metabolism";"Thiamine metabolism"
Medex_00009171-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Medex_00058885-RA	1	Reactome: R-HSA-380972	"Energy dependent regulation of mTOR by LKB1-AMPK"
Medex_00060327-RA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
Medex_00002582-RA	2	KEGG: 00260+1.4.4.2;Reactome: R-HSA-6783984	"Glycine, serine and threonine metabolism";"Glycine degradation"
Medex_00050603-RA	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
Medex_00093779-RA	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
Medex_00072601-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Medex_00033103-RA	3	MetaCyc: PWY-6348;KEGG: 00730+3.1.3.2;KEGG: 00740+3.1.3.2	"Phosphate acquisition";"Thiamine metabolism";"Riboflavin metabolism"
Medex_00030591-RA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
Medex_00048323-RA	1	Reactome: R-HSA-1632852	"Macroautophagy"
Medex_00007093-RA	1	Reactome: R-HSA-425366	"Transport of bile salts and organic acids, metal ions and amine compounds"
Medex_00066315-RA	8	Reactome: R-HSA-1855183;MetaCyc: PWY-2301;MetaCyc: PWY-4661;MetaCyc: PWY-6664;MetaCyc: PWY-6372;KEGG: 00521+5.5.1.4;KEGG: 00562+5.5.1.4;MetaCyc: PWY-6580	"Synthesis of IP2, IP, and Ins in the cytosol";"Myo-inositol biosynthesis";"1D-myo-inositol hexakisphosphate biosynthesis III (Spirodela polyrrhiza)";"Di-myo-inositol phosphate biosynthesis";"1D-myo-inositol hexakisphosphate biosynthesis IV (Dictyostelium)";"Streptomycin biosynthesis";"Inositol phosphate metabolism";"Phosphatidylinositol biosynthesis I (bacteria)"
Medex_00025044-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00035334-RA	7	MetaCyc: PWY-5265;KEGG: 00550+2.4.1.227;MetaCyc: PWY-6470;MetaCyc: PWY-6471;Reactome: R-HSA-446193;Reactome: R-HSA-5633231;MetaCyc: PWY-6385	"Peptidoglycan biosynthesis II (staphylococci)";"Peptidoglycan biosynthesis";"Peptidoglycan biosynthesis V (beta-lactam resistance)";"Peptidoglycan biosynthesis IV (Enterococcus faecium)";"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)";"Peptidoglycan biosynthesis III (mycobacteria)"
Medex_00037773-RA	24	Reactome: R-HSA-1445148;Reactome: R-HSA-5663220;Reactome: R-HSA-3371497;Reactome: R-HSA-2500257;Reactome: R-HSA-380320;Reactome: R-HSA-9646399;Reactome: R-HSA-5617833;Reactome: R-HSA-2467813;Reactome: R-HSA-68877;Reactome: R-HSA-9648025;Reactome: R-HSA-6811434;Reactome: R-HSA-9609690;Reactome: R-HSA-6811436;Reactome: R-HSA-8955332;Reactome: R-HSA-6807878;Reactome: R-HSA-437239;Reactome: R-HSA-9619483;Reactome: R-HSA-190861;Reactome: R-HSA-190840;Reactome: R-HSA-2132295;Reactome: R-HSA-5626467;Reactome: R-HSA-9609736;Reactome: R-HSA-983189;Reactome: R-HSA-8852276	"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"RHO GTPases Activate Formins";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Resolution of Sister Chromatid Cohesion";"Recruitment of NuMA to mitotic centrosomes";"Aggrephagy";"Cilium Assembly";"Separation of Sister Chromatids";"Mitotic Prometaphase";"EML4 and NUDC in mitotic spindle formation";"COPI-dependent Golgi-to-ER retrograde traffic";"HCMV Early Events";"COPI-independent Golgi-to-ER retrograde traffic";"Carboxyterminal post-translational modifications of tubulin";"COPI-mediated anterograde transport";"Recycling pathway of L1";"Activation of AMPK downstream of NMDARs";"Gap junction assembly";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"MHC class II antigen presentation";"RHO GTPases activate IQGAPs";"Assembly and cell surface presentation of NMDA receptors";"Kinesins";"The role of GTSE1 in G2/M progression after G2 checkpoint"
Medex_00015398-RA	1	Reactome: R-HSA-6811440	"Retrograde transport at the Trans-Golgi-Network"
Medex_00058558-RA	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5419276;Reactome: R-HSA-5389840	"Mitochondrial translation initiation";"Mitochondrial translation termination";"Mitochondrial translation elongation"
Medex_00024727-RA	1	Reactome: R-HSA-975957	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
Medex_00062492-RA	2	Reactome: R-HSA-8983711;Reactome: R-HSA-909733	"OAS antiviral response";"Interferon alpha/beta signaling"
Medex_00024941-RA	10	KEGG: 00562+5.3.1.1;KEGG: 00710+5.3.1.1;Reactome: R-HSA-70171;Reactome: R-HSA-70263;MetaCyc: PWY-1042;MetaCyc: PWY-7003;MetaCyc: PWY-6142;KEGG: 00010+5.3.1.1;KEGG: 00051+5.3.1.1;MetaCyc: PWY-5484	"Inositol phosphate metabolism";"Carbon fixation in photosynthetic organisms";"Glycolysis";"Gluconeogenesis";"Glycolysis IV (plant cytosol)";"Glycerol degradation to butanol";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Glycolysis / Gluconeogenesis";"Fructose and mannose metabolism";"Glycolysis II (from fructose 6-phosphate)"
Medex_00044909-RA	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
Medex_00044987-RA	2	Reactome: R-HSA-390471;Reactome: R-HSA-1660662	"Association of TriC/CCT with target proteins during biosynthesis";"Glycosphingolipid metabolism"
Medex_00015860-RA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
Medex_00027188-RA	1	Reactome: R-HSA-5693607	"Processing of DNA double-strand break ends"
Medex_00065171-RA	1	Reactome: R-HSA-162791	"Attachment of GPI anchor to uPAR"
Medex_00004648-RA	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
Medex_00006222-RA	1	Reactome: R-HSA-169911	"Regulation of Apoptosis"
Medex_00008561-RA	2	Reactome: R-HSA-418890;Reactome: R-HSA-3295583	"Role of second messengers in netrin-1 signaling";"TRP channels"
Medex_00042977-RA	1	KEGG: 00970+6.1.1.14	"Aminoacyl-tRNA biosynthesis"
Medex_00019816-RA	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
Medex_00041390-RA	1	MetaCyc: PWY-7511	"Protein ubiquitination"
Medex_00009396-RA	19	MetaCyc: PWY-7205;Reactome: R-HSA-380320;KEGG: 00983+2.7.4.6;MetaCyc: PWY-7221;MetaCyc: PWY-7210;KEGG: 00240+2.7.4.6;MetaCyc: PWY-7220;MetaCyc: PWY-7197;Reactome: R-HSA-380270;MetaCyc: PWY-7226;MetaCyc: PWY-7227;MetaCyc: PWY-7198;KEGG: 00230+2.7.4.6;MetaCyc: PWY-7224;MetaCyc: PWY-7187;MetaCyc: PWY-7184;MetaCyc: PWY-7176;MetaCyc: PWY-6545;MetaCyc: PWY-7222	"CMP phosphorylation";"Recruitment of NuMA to mitotic centrosomes";"Drug metabolism - other enzymes";"Guanosine ribonucleotides de novo biosynthesis";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Pyrimidine metabolism";"Adenosine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotide phosphorylation";"Recruitment of mitotic centrosome proteins and complexes";"Guanosine deoxyribonucleotides de novo biosynthesis I";"Adenosine deoxyribonucleotides de novo biosynthesis";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Purine metabolism";"Purine deoxyribonucleosides salvage";"Pyrimidine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"UTP and CTP de novo biosynthesis";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Guanosine deoxyribonucleotides de novo biosynthesis II"
Medex_00021198-RA	2	Reactome: R-HSA-418990;Reactome: R-HSA-5218920	"Adherens junctions interactions";"VEGFR2 mediated vascular permeability"
Medex_00032967-RA	1	KEGG: 00970+6.1.1.2	"Aminoacyl-tRNA biosynthesis"
Medex_00054079-RA	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
Medex_00031614-RA	3	Reactome: R-HSA-5696394;Reactome: R-HSA-5689603;Reactome: R-HSA-3214847	"DNA Damage Recognition in GG-NER";"UCH proteinases";"HATs acetylate histones"
Medex_00032770-RA	2	Reactome: R-HSA-5689603;Reactome: R-HSA-5696394	"UCH proteinases";"DNA Damage Recognition in GG-NER"
Medex_00027742-RA	30	Reactome: R-HSA-195253;Reactome: R-HSA-400253;Reactome: R-HSA-174113;Reactome: R-HSA-8939902;Reactome: R-HSA-9604323;Reactome: R-HSA-5676590;Reactome: R-HSA-5610785;Reactome: R-HSA-5607764;Reactome: R-HSA-180534;Reactome: R-HSA-1170546;Reactome: R-HSA-69231;Reactome: R-HSA-1169091;Reactome: R-HSA-2644606;Reactome: R-HSA-917937;Reactome: R-HSA-2871837;Reactome: R-HSA-5610780;Reactome: R-HSA-8951664;Reactome: R-HSA-5607761;Reactome: R-HSA-202424;Reactome: R-HSA-983168;Reactome: R-HSA-2565942;Reactome: R-HSA-2894862;Reactome: R-HSA-187577;Reactome: R-HSA-2644607;Reactome: R-HSA-9020702;Reactome: R-HSA-2122947;Reactome: R-HSA-5684264;Reactome: R-HSA-8854050;Reactome: R-HSA-5610783;Reactome: R-HSA-68949	"Degradation of beta-catenin by the destruction complex";"Circadian Clock";"SCF-beta-TrCP mediated degradation of Emi1";"Regulation of RUNX2 expression and activity";"Negative regulation of NOTCH4 signaling";"NIK-->noncanonical NF-kB signaling";"GLI3 is processed to GLI3R by the proteasome";"CLEC7A (Dectin-1) signaling";"Vpu mediated degradation of CD4";"Prolactin receptor signaling";"Cyclin D associated events in G1";"Activation of NF-kappaB in B cells";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Iron uptake and transport";"FCERI mediated NF-kB activation";"Degradation of GLI1 by the proteasome";"Neddylation";"Dectin-1 mediated noncanonical NF-kB signaling";"Downstream TCR signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Regulation of PLK1 Activity at G2/M Transition";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"SCF(Skp2)-mediated degradation of p27/p21";"Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling";"Interleukin-1 signaling";"NOTCH1 Intracellular Domain Regulates Transcription";"MAP3K8 (TPL2)-dependent MAPK1/3 activation";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Degradation of GLI2 by the proteasome";"Orc1 removal from chromatin"
Medex_00054297-RA	2	Reactome: R-HSA-390471;Reactome: R-HSA-1660662	"Association of TriC/CCT with target proteins during biosynthesis";"Glycosphingolipid metabolism"
Medex_00043200-RA	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00066753-RA	56	Reactome: R-HSA-5610783;Reactome: R-HSA-1236974;Reactome: R-HSA-8854050;Reactome: R-HSA-187577;Reactome: R-HSA-174084;Reactome: R-HSA-1169091;Reactome: R-HSA-174154;Reactome: R-HSA-174184;Reactome: R-HSA-5607764;Reactome: R-HSA-8951664;Reactome: R-HSA-2871837;Reactome: R-HSA-350562;Reactome: R-HSA-69481;Reactome: R-HSA-5678895;Reactome: R-HSA-174113;Reactome: R-HSA-4641257;Reactome: R-HSA-5362768;Reactome: R-HSA-69601;Reactome: R-HSA-69017;Reactome: R-HSA-1234176;Reactome: R-HSA-5676590;Reactome: R-HSA-68827;Reactome: R-HSA-9604323;Reactome: R-HSA-8948751;Reactome: R-HSA-4641258;Reactome: R-HSA-2467813;Reactome: R-HSA-180585;Reactome: R-HSA-450408;Reactome: R-HSA-9010553;Reactome: R-HSA-211733;Reactome: R-HSA-8939236;Reactome: R-HSA-382556;Reactome: R-HSA-68949;Reactome: R-HSA-5658442;Reactome: R-HSA-8941858;Reactome: R-HSA-5358346;Reactome: R-HSA-983168;Reactome: R-HSA-202424;Reactome: R-HSA-9020702;Reactome: R-HSA-5632684;Reactome: R-HSA-349425;Reactome: R-HSA-1236978;Reactome: R-HSA-180534;Reactome: R-HSA-5607761;Reactome: R-HSA-8852276;Reactome: R-HSA-5610780;Reactome: R-HSA-174178;Reactome: R-HSA-8939902;Reactome: R-HSA-75815;Reactome: R-HSA-195253;Reactome: R-HSA-5610785;Reactome: R-HSA-5689880;Reactome: R-HSA-5689603;Reactome: R-HSA-5687128;Reactome: R-HSA-5668541;Reactome: R-HSA-4608870	"Degradation of GLI2 by the proteasome";"ER-Phagosome pathway";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"SCF(Skp2)-mediated degradation of p27/p21";"Autodegradation of Cdh1 by Cdh1:APC/C";"Activation of NF-kappaB in B cells";"APC/C:Cdc20 mediated degradation of Securin";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"CLEC7A (Dectin-1) signaling";"Neddylation";"FCERI mediated NF-kB activation";"Regulation of ornithine decarboxylase (ODC)";"G2/M Checkpoints";"Defective CFTR causes cystic fibrosis";"SCF-beta-TrCP mediated degradation of Emi1";"Degradation of AXIN";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"CDK-mediated phosphorylation and removal of Cdc6";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"NIK-->noncanonical NF-kB signaling";"CDT1 association with the CDC6:ORC:origin complex";"Negative regulation of NOTCH4 signaling";"Regulation of PTEN stability and activity";"Degradation of DVL";"Separation of Sister Chromatids";"Vif-mediated degradation of APOBEC3G";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Regulation of expression of SLITs and ROBOs";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"ABC-family proteins mediated transport";"Orc1 removal from chromatin";"Regulation of RAS by GAPs";"Regulation of RUNX3 expression and activity";"Hedgehog ligand biogenesis";"Antigen processing: Ubiquitination & Proteasome degradation";"Downstream TCR signaling";"Interleukin-1 signaling";"Hedgehog 'on' state";"Autodegradation of the E3 ubiquitin ligase COP1";"Cross-presentation of soluble exogenous antigens (endosomes)";"Vpu mediated degradation of CD4";"Dectin-1 mediated noncanonical NF-kB signaling";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Degradation of GLI1 by the proteasome";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Regulation of RUNX2 expression and activity";"Ubiquitin-dependent degradation of Cyclin D";"Degradation of beta-catenin by the destruction complex";"GLI3 is processed to GLI3R by the proteasome";"Ub-specific processing proteases";"UCH proteinases";"MAPK6/MAPK4 signaling";"TNFR2 non-canonical NF-kB pathway";"Asymmetric localization of PCP proteins"
Medex_00026846-RA	2	Reactome: R-HSA-3299685;MetaCyc: PWY-6854	"Detoxification of Reactive Oxygen Species";"Ethylene biosynthesis III (microbes)"
Medex_00072172-RA	2	Reactome: R-HSA-381340;Reactome: R-HSA-1989781	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression"
Medex_00011893-RA	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
Medex_00034038-RA	2	Reactome: R-HSA-6783310;Reactome: R-HSA-5693568	"Fanconi Anemia Pathway";"Resolution of D-loop Structures through Holliday Junction Intermediates"
Medex_00065966-RA	6	Reactome: R-HSA-3000171;Reactome: R-HSA-2022090;Reactome: R-HSA-8948216;Reactome: R-HSA-1442490;Reactome: R-HSA-8874081;Reactome: R-HSA-1650814	"Non-integrin membrane-ECM interactions";"Assembly of collagen fibrils and other multimeric structures";"Collagen chain trimerization";"Collagen degradation";"MET activates PTK2 signaling";"Collagen biosynthesis and modifying enzymes"
Medex_00017967-RA	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
Medex_00052204-RA	1	Reactome: R-HSA-6784531	"tRNA processing in the nucleus"
Medex_00026269-RA	1	Reactome: R-HSA-5689603	"UCH proteinases"
Medex_00074851-RA	4	Reactome: R-HSA-422085;Reactome: R-HSA-381771;Reactome: R-HSA-1799339;Reactome: R-HSA-400511	"Synthesis, secretion, and deacylation of Ghrelin";"Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)";"SRP-dependent cotranslational protein targeting to membrane";"Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)"
Medex_00015533-RA	6	MetaCyc: PWY-6807;KEGG: 00600+3.2.1.23;KEGG: 00511+3.2.1.23;KEGG: 00604+3.2.1.23;KEGG: 00052+3.2.1.23;KEGG: 00531+3.2.1.23	"Xyloglucan degradation II (exoglucanase)";"Sphingolipid metabolism";"Other glycan degradation";"Glycosphingolipid biosynthesis - ganglio series";"Galactose metabolism";"Glycosaminoglycan degradation"
Medex_00018789-RA	52	Reactome: R-HSA-5676590;Reactome: R-HSA-69017;Reactome: R-HSA-1234176;Reactome: R-HSA-69601;Reactome: R-HSA-5362768;Reactome: R-HSA-8948751;Reactome: R-HSA-68827;Reactome: R-HSA-5678895;Reactome: R-HSA-69481;Reactome: R-HSA-350562;Reactome: R-HSA-4641257;Reactome: R-HSA-174113;Reactome: R-HSA-2871837;Reactome: R-HSA-8951664;Reactome: R-HSA-174154;Reactome: R-HSA-1169091;Reactome: R-HSA-174184;Reactome: R-HSA-5607764;Reactome: R-HSA-5610783;Reactome: R-HSA-8854050;Reactome: R-HSA-1236974;Reactome: R-HSA-5689880;Reactome: R-HSA-5610785;Reactome: R-HSA-4608870;Reactome: R-HSA-5689603;Reactome: R-HSA-5687128;Reactome: R-HSA-5668541;Reactome: R-HSA-75815;Reactome: R-HSA-8939902;Reactome: R-HSA-195253;Reactome: R-HSA-5610780;Reactome: R-HSA-8852276;Reactome: R-HSA-5607761;Reactome: R-HSA-174178;Reactome: R-HSA-5632684;Reactome: R-HSA-180534;Reactome: R-HSA-1236978;Reactome: R-HSA-349425;Reactome: R-HSA-9020702;Reactome: R-HSA-5358346;Reactome: R-HSA-5658442;Reactome: R-HSA-202424;Reactome: R-HSA-983168;Reactome: R-HSA-382556;Reactome: R-HSA-68949;Reactome: R-HSA-8939236;Reactome: R-HSA-211733;Reactome: R-HSA-9010553;Reactome: R-HSA-2467813;Reactome: R-HSA-4641258;Reactome: R-HSA-450408;Reactome: R-HSA-180585	"NIK-->noncanonical NF-kB signaling";"CDK-mediated phosphorylation and removal of Cdc6";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Regulation of PTEN stability and activity";"CDT1 association with the CDC6:ORC:origin complex";"Defective CFTR causes cystic fibrosis";"G2/M Checkpoints";"Regulation of ornithine decarboxylase (ODC)";"Degradation of AXIN";"SCF-beta-TrCP mediated degradation of Emi1";"FCERI mediated NF-kB activation";"Neddylation";"APC/C:Cdc20 mediated degradation of Securin";"Activation of NF-kappaB in B cells";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"CLEC7A (Dectin-1) signaling";"Degradation of GLI2 by the proteasome";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"ER-Phagosome pathway";"Ub-specific processing proteases";"GLI3 is processed to GLI3R by the proteasome";"Asymmetric localization of PCP proteins";"UCH proteinases";"MAPK6/MAPK4 signaling";"TNFR2 non-canonical NF-kB pathway";"Ubiquitin-dependent degradation of Cyclin D";"Regulation of RUNX2 expression and activity";"Degradation of beta-catenin by the destruction complex";"Degradation of GLI1 by the proteasome";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Dectin-1 mediated noncanonical NF-kB signaling";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Hedgehog 'on' state";"Vpu mediated degradation of CD4";"Cross-presentation of soluble exogenous antigens (endosomes)";"Autodegradation of the E3 ubiquitin ligase COP1";"Interleukin-1 signaling";"Hedgehog ligand biogenesis";"Regulation of RAS by GAPs";"Downstream TCR signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"ABC-family proteins mediated transport";"Orc1 removal from chromatin";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Regulation of expression of SLITs and ROBOs";"Separation of Sister Chromatids";"Degradation of DVL";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Vif-mediated degradation of APOBEC3G"
Medex_00034763-RA	12	Reactome: R-HSA-1169408;Reactome: R-HSA-450408;Reactome: R-HSA-975957;Reactome: R-HSA-429947;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-72649;Reactome: R-HSA-166208;Reactome: R-HSA-72662;Reactome: R-HSA-72706;Reactome: R-HSA-975956;Reactome: R-HSA-72702	"ISG15 antiviral mechanism";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Deadenylation of mRNA";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Translation initiation complex formation";"mTORC1-mediated signalling";"Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Ribosomal scanning and start codon recognition"
Medex_00028732-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00048546-RA	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5419276;Reactome: R-HSA-5389840	"Mitochondrial translation initiation";"Mitochondrial translation termination";"Mitochondrial translation elongation"
Medex_00044366-RA	6	KEGG: 00260+5.4.2.11;MetaCyc: PWY-8004;MetaCyc: PWY-1622;KEGG: 00680+5.4.2.11;MetaCyc: PWY-5484;KEGG: 00010+5.4.2.11	"Glycine, serine and threonine metabolism";"Entner-Doudoroff pathway I";"Formaldehyde assimilation I (serine pathway)";"Methane metabolism";"Glycolysis II (from fructose 6-phosphate)";"Glycolysis / Gluconeogenesis"
Medex_00084577-RA	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
Medex_00039920-RA	11	KEGG: 04926+2.7.11.1;Reactome: R-HSA-5693571;KEGG: 05163+2.7.11.1;Reactome: R-HSA-3270619;KEGG: 04151+2.7.11.1;KEGG: 04714+2.7.11.1;Reactome: R-HSA-8866654;KEGG: 05170+2.7.11.1;Reactome: R-HSA-1834949;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1	"Relaxin signaling pathway";"Nonhomologous End-Joining (NHEJ)";"Human cytomegalovirus infection";"IRF3-mediated induction of type I IFN";"PI3K-Akt signaling pathway";"Thermogenesis";"E3 ubiquitin ligases ubiquitinate target proteins";"Human immunodeficiency virus 1 infection";"Cytosolic sensors of pathogen-associated DNA";"mTOR signaling pathway";"Human papillomavirus infection"
Medex_00000074-RA	1	KEGG: 00480+3.4.11.2	"Glutathione metabolism"
Medex_00033147-RA	52	Reactome: R-HSA-75815;Reactome: R-HSA-8939902;Reactome: R-HSA-195253;Reactome: R-HSA-5610785;Reactome: R-HSA-5689880;Reactome: R-HSA-4608870;Reactome: R-HSA-5689603;Reactome: R-HSA-5687128;Reactome: R-HSA-5668541;Reactome: R-HSA-5632684;Reactome: R-HSA-180534;Reactome: R-HSA-1236978;Reactome: R-HSA-349425;Reactome: R-HSA-8852276;Reactome: R-HSA-5610780;Reactome: R-HSA-5607761;Reactome: R-HSA-174178;Reactome: R-HSA-5358346;Reactome: R-HSA-5658442;Reactome: R-HSA-202424;Reactome: R-HSA-983168;Reactome: R-HSA-9020702;Reactome: R-HSA-2467813;Reactome: R-HSA-4641258;Reactome: R-HSA-450408;Reactome: R-HSA-180585;Reactome: R-HSA-68949;Reactome: R-HSA-382556;Reactome: R-HSA-8939236;Reactome: R-HSA-211733;Reactome: R-HSA-9010553;Reactome: R-HSA-5678895;Reactome: R-HSA-69481;Reactome: R-HSA-350562;Reactome: R-HSA-4641257;Reactome: R-HSA-174113;Reactome: R-HSA-5676590;Reactome: R-HSA-69017;Reactome: R-HSA-69601;Reactome: R-HSA-5362768;Reactome: R-HSA-1234176;Reactome: R-HSA-68827;Reactome: R-HSA-8948751;Reactome: R-HSA-174154;Reactome: R-HSA-1169091;Reactome: R-HSA-5607764;Reactome: R-HSA-174184;Reactome: R-HSA-2871837;Reactome: R-HSA-8951664;Reactome: R-HSA-5610783;Reactome: R-HSA-8854050;Reactome: R-HSA-1236974	"Ubiquitin-dependent degradation of Cyclin D";"Regulation of RUNX2 expression and activity";"Degradation of beta-catenin by the destruction complex";"GLI3 is processed to GLI3R by the proteasome";"Ub-specific processing proteases";"Asymmetric localization of PCP proteins";"UCH proteinases";"MAPK6/MAPK4 signaling";"TNFR2 non-canonical NF-kB pathway";"Hedgehog 'on' state";"Vpu mediated degradation of CD4";"Cross-presentation of soluble exogenous antigens (endosomes)";"Autodegradation of the E3 ubiquitin ligase COP1";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Degradation of GLI1 by the proteasome";"Dectin-1 mediated noncanonical NF-kB signaling";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Hedgehog ligand biogenesis";"Regulation of RAS by GAPs";"Downstream TCR signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Interleukin-1 signaling";"Separation of Sister Chromatids";"Degradation of DVL";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Vif-mediated degradation of APOBEC3G";"Orc1 removal from chromatin";"ABC-family proteins mediated transport";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Regulation of expression of SLITs and ROBOs";"Defective CFTR causes cystic fibrosis";"G2/M Checkpoints";"Regulation of ornithine decarboxylase (ODC)";"Degradation of AXIN";"SCF-beta-TrCP mediated degradation of Emi1";"NIK-->noncanonical NF-kB signaling";"CDK-mediated phosphorylation and removal of Cdc6";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"CDT1 association with the CDC6:ORC:origin complex";"Regulation of PTEN stability and activity";"APC/C:Cdc20 mediated degradation of Securin";"Activation of NF-kappaB in B cells";"CLEC7A (Dectin-1) signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"FCERI mediated NF-kB activation";"Neddylation";"Degradation of GLI2 by the proteasome";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"ER-Phagosome pathway"
Medex_00091684-RA	6	MetaCyc: PWY-6733;MetaCyc: PWY-7782;MetaCyc: PWY-7656;KEGG: 00073+1.2.1.84;Reactome: R-HSA-9640463;MetaCyc: PWY-5884	"Sporopollenin precursors biosynthesis";"Plasmalogen biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax biosynthesis";"Wax esters biosynthesis I"
Medex_00080920-RA	5	Reactome: R-HSA-381426;Reactome: R-HSA-901042;Reactome: R-HSA-8957275;Reactome: R-HSA-879415;Reactome: R-HSA-532668	"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"Calnexin/calreticulin cycle";"Post-translational protein phosphorylation";"Advanced glycosylation endproduct receptor signaling";"N-glycan trimming in the ER and Calnexin/Calreticulin cycle"
Medex_00033343-RA	1	Reactome: R-HSA-427975	"Proton/oligopeptide cotransporters"
Medex_00028124-RA	1	Reactome: R-HSA-6785631	"ERBB2 Regulates Cell Motility"
Medex_00030366-RA	20	KEGG: 05165+2.7.11.1;Reactome: R-HSA-1632852;Reactome: R-HSA-165159;Reactome: R-HSA-166208;KEGG: 05170+2.7.11.1;Reactome: R-HSA-380972;Reactome: R-HSA-8943724;Reactome: R-HSA-6804757;KEGG: 04926+2.7.11.1;Reactome: R-HSA-1257604;KEGG: 04150+2.7.11.1;Reactome: R-HSA-9639288;Reactome: R-HSA-3371571;KEGG: 04714+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05163+2.7.11.1;Reactome: R-HSA-5218920;Reactome: R-HSA-389357;Reactome: R-HSA-5628897;Reactome: R-HSA-5674400	"Human papillomavirus infection";"Macroautophagy";"mTOR signalling";"mTORC1-mediated signalling";"Human immunodeficiency virus 1 infection";"Energy dependent regulation of mTOR by LKB1-AMPK";"Regulation of PTEN gene transcription";"Regulation of TP53 Degradation";"Relaxin signaling pathway";"PIP3 activates AKT signaling";"mTOR signaling pathway";"Amino acids regulate mTORC1";"HSF1-dependent transactivation";"Thermogenesis";"PI3K-Akt signaling pathway";"Human cytomegalovirus infection";"VEGFR2 mediated vascular permeability";"CD28 dependent PI3K/Akt signaling";"TP53 Regulates Metabolic Genes";"Constitutive Signaling by AKT1 E17K in Cancer"
Medex_00001629-RA	13	MetaCyc: PWY-6351;Reactome: R-HSA-2871809;MetaCyc: PWY-7039;Reactome: R-HSA-9027277;KEGG: 00562+3.1.4.11;Reactome: R-HSA-2871796;Reactome: R-HSA-202433;MetaCyc: PWY-8052;Reactome: R-HSA-1855204;Reactome: R-HSA-2029485;Reactome: R-HSA-2424491;KEGG: 04070+3.1.4.11;MetaCyc: PWY-6367	"D-myo-inositol (1,4,5)-trisphosphate biosynthesis";"FCERI mediated Ca+2 mobilization";"Phosphatidate metabolism, as a signaling molecule";"Erythropoietin activates Phospholipase C gamma (PLCG)";"Inositol phosphate metabolism";"FCERI mediated MAPK activation";"Generation of second messenger molecules";"2-arachidonoylglycerol biosynthesis";"Synthesis of IP3 and IP4 in the cytosol";"Role of phospholipids in phagocytosis";"DAP12 signaling";"Phosphatidylinositol signaling system";"D-myo-inositol-5-phosphate metabolism"
Medex_00025576-RA	6	MetaCyc: PWY-5686;MetaCyc: PWY-7791;MetaCyc: PWY-7790;KEGG: 00240+2.1.3.2;KEGG: 00250+2.1.3.2;Reactome: R-HSA-500753	"UMP biosynthesis I";"UMP biosynthesis III";"UMP biosynthesis II";"Pyrimidine metabolism";"Alanine, aspartate and glutamate metabolism";"Pyrimidine biosynthesis"
Medex_00076880-RA	2	Reactome: R-HSA-983168;Reactome: R-HSA-110320	"Antigen processing: Ubiquitination & Proteasome degradation";"Translesion Synthesis by POLH"
Medex_00044519-RA	1	Reactome: R-HSA-156588	"Glucuronidation"
Medex_00021580-RA	5	MetaCyc: PWY-6121;KEGG: 00230+6.3.3.1;Reactome: R-HSA-73817;MetaCyc: PWY-6122;MetaCyc: PWY-6277	"5-aminoimidazole ribonucleotide biosynthesis I";"Purine metabolism";"Purine ribonucleoside monophosphate biosynthesis";"5-aminoimidazole ribonucleotide biosynthesis II";"Superpathway of 5-aminoimidazole ribonucleotide biosynthesis"
Medex_00027616-RA	2	Reactome: R-HSA-5610787;Reactome: R-HSA-5620924	"Hedgehog 'off' state";"Intraflagellar transport"
Medex_00031910-RA	3	Reactome: R-HSA-159740;KEGG: 00130+4.1.1.90;MetaCyc: PWY-7999	"Gamma-carboxylation of protein precursors";"Ubiquinone and other terpenoid-quinone biosynthesis";"Vitamin K-epoxide cycle"
Medex_00022505-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00002918-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00018185-RA	26	Reactome: R-HSA-2500257;Reactome: R-HSA-380320;Reactome: R-HSA-3371497;Reactome: R-HSA-5663220;Reactome: R-HSA-1445148;Reactome: R-HSA-389960;Reactome: R-HSA-68877;Reactome: R-HSA-9648025;Reactome: R-HSA-6811434;Reactome: R-HSA-389977;Reactome: R-HSA-2467813;Reactome: R-HSA-5617833;Reactome: R-HSA-9646399;Reactome: R-HSA-5626467;Reactome: R-HSA-2132295;Reactome: R-HSA-6807878;Reactome: R-HSA-190840;Reactome: R-HSA-190861;Reactome: R-HSA-437239;Reactome: R-HSA-9619483;Reactome: R-HSA-6811436;Reactome: R-HSA-9609690;Reactome: R-HSA-8955332;Reactome: R-HSA-8852276;Reactome: R-HSA-983189;Reactome: R-HSA-9609736	"Resolution of Sister Chromatid Cohesion";"Recruitment of NuMA to mitotic centrosomes";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"RHO GTPases Activate Formins";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Formation of tubulin folding intermediates by CCT/TriC";"Mitotic Prometaphase";"EML4 and NUDC in mitotic spindle formation";"COPI-dependent Golgi-to-ER retrograde traffic";"Post-chaperonin tubulin folding pathway";"Separation of Sister Chromatids";"Cilium Assembly";"Aggrephagy";"RHO GTPases activate IQGAPs";"MHC class II antigen presentation";"COPI-mediated anterograde transport";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Gap junction assembly";"Recycling pathway of L1";"Activation of AMPK downstream of NMDARs";"COPI-independent Golgi-to-ER retrograde traffic";"HCMV Early Events";"Carboxyterminal post-translational modifications of tubulin";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Kinesins";"Assembly and cell surface presentation of NMDA receptors"
Medex_00090175-RA	15	Reactome: R-HSA-9665249;Reactome: R-HSA-9665251;Reactome: R-HSA-9665244;Reactome: R-HSA-1236382;Reactome: R-HSA-9652282;Reactome: R-HSA-9665245;Reactome: R-HSA-9665246;Reactome: R-HSA-9664565;Reactome: R-HSA-1227986;Reactome: R-HSA-9634285;Reactome: R-HSA-9665247;Reactome: R-HSA-8863795;Reactome: R-HSA-9665250;Reactome: R-HSA-9665233;Reactome: R-HSA-5637810	"Resistance of ERBB2 KD mutants to afatinib";"Resistance of ERBB2 KD mutants to lapatinib";"Resistance of ERBB2 KD mutants to sapitinib";"Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants";"Drug-mediated inhibition of ERBB2 signaling";"Resistance of ERBB2 KD mutants to tesevatinib";"Resistance of ERBB2 KD mutants to neratinib";"Signaling by ERBB2 KD Mutants";"Signaling by ERBB2";"Constitutive Signaling by Overexpressed ERBB2";"Resistance of ERBB2 KD mutants to osimertinib";"Downregulation of ERBB2 signaling";"Resistance of ERBB2 KD mutants to AEE788";"Resistance of ERBB2 KD mutants to trastuzumab";"Constitutive Signaling by EGFRvIII"
Medex_00021808-RA	10	KEGG: 00052+3.2.1.23;KEGG: 00531+3.2.1.23;Reactome: R-HSA-6798695;KEGG: 00600+3.2.1.23;Reactome: R-HSA-2160916;Reactome: R-HSA-2206292;Reactome: R-HSA-2024096;MetaCyc: PWY-6807;KEGG: 00511+3.2.1.23;KEGG: 00604+3.2.1.23	"Galactose metabolism";"Glycosaminoglycan degradation";"Neutrophil degranulation";"Sphingolipid metabolism";"Hyaluronan uptake and degradation";"MPS VII - Sly syndrome";"HS-GAG degradation";"Xyloglucan degradation II (exoglucanase)";"Other glycan degradation";"Glycosphingolipid biosynthesis - ganglio series"
Medex_00075594-RA	1	Reactome: R-HSA-73621	"Pyrimidine catabolism"
Medex_00022929-RA	1	Reactome: R-HSA-3238698	"WNT ligand biogenesis and trafficking"
Medex_00006247-RA	1	Reactome: R-HSA-8951664	"Neddylation"
Medex_00072096-RA	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
Medex_00025617-RA	1	Reactome: R-HSA-8951664	"Neddylation"
Medex_00048992-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Medex_00019057-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Medex_00073697-RA	3	Reactome: R-HSA-72163;Reactome: R-HSA-5250924;Reactome: R-HSA-72165	"mRNA Splicing - Major Pathway";"B-WICH complex positively regulates rRNA expression";"mRNA Splicing - Minor Pathway"
Medex_00052897-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00061381-RA	17	MetaCyc: PWY-5690;MetaCyc: PWY-6728;KEGG: 00720+1.1.1.37;KEGG: 00630+1.1.1.37;KEGG: 00620+1.1.1.37;MetaCyc: PWY-561;MetaCyc: PWY-5392;MetaCyc: PWY-8086;MetaCyc: PWY-1622;KEGG: 00710+1.1.1.37;MetaCyc: PWY-6969;MetaCyc: PWY-5913;KEGG: 00270+1.1.1.37;KEGG: 00020+1.1.1.37;MetaCyc: PWY-7115;MetaCyc: PWY-7383;KEGG: 00680+1.1.1.37	"TCA cycle II (plants and fungi)";"Methylaspartate cycle";"Carbon fixation pathways in prokaryotes";"Glyoxylate and dicarboxylate metabolism";"Pyruvate metabolism";"Superpathway of glyoxylate cycle and fatty acid degradation";"Reductive TCA cycle II";"(S)-lactate fermentation to propanoate, acetate and hydrogen";"Formaldehyde assimilation I (serine pathway)";"Carbon fixation in photosynthetic organisms";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Partial TCA cycle (obligate autotrophs)";"Cysteine and methionine metabolism";"Citrate cycle (TCA cycle)";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"Anaerobic energy metabolism (invertebrates, cytosol)";"Methane metabolism"
Medex_00040971-RA	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
Medex_00075126-RA	2	Reactome: R-HSA-2132295;Reactome: R-HSA-877300	"MHC class II antigen presentation";"Interferon gamma signaling"
Medex_00084928-RA	1	Reactome: R-HSA-1799339	"SRP-dependent cotranslational protein targeting to membrane"
Medex_00064853-RA	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5419276;Reactome: R-HSA-5389840	"Mitochondrial translation initiation";"Mitochondrial translation termination";"Mitochondrial translation elongation"
Medex_00059900-RA	2	Reactome: R-HSA-190373;Reactome: R-HSA-5654726	"FGFR1c ligand binding and activation";"Negative regulation of FGFR1 signaling"
Medex_00069124-RA	6	Reactome: R-HSA-2467813;Reactome: R-HSA-5663220;Reactome: R-HSA-9648025;Reactome: R-HSA-2500257;Reactome: R-HSA-68877;Reactome: R-HSA-141444	"Separation of Sister Chromatids";"RHO GTPases Activate Formins";"EML4 and NUDC in mitotic spindle formation";"Resolution of Sister Chromatid Cohesion";"Mitotic Prometaphase";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"
Medex_00009658-RA	3	Reactome: R-HSA-6787639;KEGG: 00520+1.1.1.271;KEGG: 00051+1.1.1.271	"GDP-fucose biosynthesis";"Amino sugar and nucleotide sugar metabolism";"Fructose and mannose metabolism"
Medex_00004160-RA	1	Reactome: R-HSA-204005	"COPII-mediated vesicle transport"
Medex_00009497-RA	5	Reactome: R-HSA-5694530;Reactome: R-HSA-1655829;Reactome: R-HSA-204005;Reactome: R-HSA-2132295;Reactome: R-HSA-983170	"Cargo concentration in the ER";"Regulation of cholesterol biosynthesis by SREBP (SREBF)";"COPII-mediated vesicle transport";"MHC class II antigen presentation";"Antigen Presentation: Folding, assembly and peptide loading of class I MHC"
Medex_00026862-RA	1	Reactome: R-HSA-2151201	"Transcriptional activation of mitochondrial biogenesis"
Medex_00039873-RA	2	Reactome: R-HSA-901032;MetaCyc: PWY-7511	"ER Quality Control Compartment (ERQC)";"Protein ubiquitination"
Medex_00008695-RA	5	Reactome: R-HSA-380994;Reactome: R-HSA-2426168;Reactome: R-HSA-1989781;Reactome: R-HSA-9614657;Reactome: R-HSA-381183	"ATF4 activates genes in response to endoplasmic reticulum stress";"Activation of gene expression by SREBF (SREBP)";"PPARA activates gene expression";"FOXO-mediated transcription of cell death genes";"ATF6 (ATF6-alpha) activates chaperone genes"
Medex_00036842-RA	1	Reactome: R-HSA-202733	"Cell surface interactions at the vascular wall"
Medex_00015861-RA	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
Medex_00067159-RA	1	Reactome: R-HSA-1445148	"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
Medex_00012509-RA	3	KEGG: 04660+2.7.10.2;Reactome: R-HSA-8854691;Reactome: R-HSA-6785807	"T cell receptor signaling pathway";"Interleukin-20 family signaling";"Interleukin-4 and Interleukin-13 signaling"
Medex_00017611-RA	1	Reactome: R-HSA-1483148	"Synthesis of PG"
Medex_00074010-RA	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
Medex_00053774-RA	1	Reactome: R-HSA-8856828	"Clathrin-mediated endocytosis"
Medex_00096738-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00031273-RA	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
Medex_00025096-RA	5	Reactome: R-HSA-6798695;KEGG: 00240+3.6.1.6;KEGG: 00230+3.6.1.6;MetaCyc: PWY-7185;MetaCyc: PWY-7210	"Neutrophil degranulation";"Pyrimidine metabolism";"Purine metabolism";"UTP and CTP dephosphorylation I";"Pyrimidine deoxyribonucleotides biosynthesis from CTP"
Medex_00072322-RA	1	Reactome: R-HSA-6798163	"Choline catabolism"
Medex_00034821-RA	1	Reactome: R-HSA-425986	"Sodium/Proton exchangers"
Medex_00025114-RA	1	Reactome: R-HSA-6809371	"Formation of the cornified envelope"
Medex_00041833-RA	1	Reactome: R-HSA-6798163	"Choline catabolism"
Medex_00044424-RA	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
Medex_00013315-RA	1	Reactome: R-HSA-189200	"Cellular hexose transport"
Medex_00022035-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00078793-RA	2	Reactome: R-HSA-390471;Reactome: R-HSA-1660662	"Association of TriC/CCT with target proteins during biosynthesis";"Glycosphingolipid metabolism"
Medex_00078855-RA	2	Reactome: R-HSA-6811434;Reactome: R-HSA-6807878	"COPI-dependent Golgi-to-ER retrograde traffic";"COPI-mediated anterograde transport"
Medex_00075831-RA	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
Medex_00060808-RA	7	MetaCyc: PWY-882;MetaCyc: PWY-5659;KEGG: 00051+5.4.2.8;KEGG: 00520+5.4.2.8;MetaCyc: PWY-7456;Reactome: R-HSA-446205;MetaCyc: PWY-7586	"L-ascorbate biosynthesis I (L-galactose pathway)";"GDP-mannose biosynthesis";"Fructose and mannose metabolism";"Amino sugar and nucleotide sugar metabolism";"Beta-(1,4)-mannan degradation";"Synthesis of GDP-mannose";"Beta-1,4-d-mannosyl-n-acetyl-d-glucosamine degradation"
Medex_00067138-RA	4	Reactome: R-HSA-8951664;Reactome: R-HSA-6781823;Reactome: R-HSA-8856825;Reactome: R-HSA-5696394	"Neddylation";"Formation of TC-NER Pre-Incision Complex";"Cargo recognition for clathrin-mediated endocytosis";"DNA Damage Recognition in GG-NER"
Medex_00016844-RA	2	Reactome: R-HSA-9033500;Reactome: R-HSA-9033241	"TYSND1 cleaves peroxisomal proteins";"Peroxisomal protein import"
Medex_00000132-RA	13	Reactome: R-HSA-381676;Reactome: R-HSA-5218921;Reactome: R-HSA-114508;Reactome: R-HSA-5607763;Reactome: R-HSA-5578775;Reactome: R-HSA-2871809;Reactome: R-HSA-4086398;Reactome: R-HSA-112043;Reactome: R-HSA-422356;Reactome: R-HSA-2029485;Reactome: R-HSA-1489509;Reactome: R-HSA-139853;Reactome: R-HSA-983695	"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"VEGFR2 mediated cell proliferation";"Effects of PIP2 hydrolysis";"CLEC7A (Dectin-1) induces NFAT activation";"Ion homeostasis";"FCERI mediated Ca+2 mobilization";"Ca2+ pathway";"PLC beta mediated events";"Regulation of insulin secretion";"Role of phospholipids in phagocytosis";"DAG and IP3 signaling";"Elevation of cytosolic Ca2+ levels";"Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"
Medex_00014230-RA	2	MetaCyc: PWY-7851;KEGG: 00770+2.7.1.24	"Coenzyme A biosynthesis II (eukaryotic)";"Pantothenate and CoA biosynthesis"
Medex_00034742-RA	5	Reactome: R-HSA-4085001;Reactome: R-HSA-1660662;Reactome: R-HSA-4341670;Reactome: R-HSA-6798695;Reactome: R-HSA-2132295	"Sialic acid metabolism";"Glycosphingolipid metabolism";"Defective NEU1 causes sialidosis";"Neutrophil degranulation";"MHC class II antigen presentation"
Medex_00007632-RA	11	Reactome: R-HSA-72163;Reactome: R-HSA-2644606;Reactome: R-HSA-2122947;Reactome: R-HSA-9013695;Reactome: R-HSA-210744;Reactome: R-HSA-350054;Reactome: R-HSA-8941856;Reactome: R-HSA-1912408;Reactome: R-HSA-9013508;Reactome: R-HSA-2173796;Reactome: R-HSA-2894862	"mRNA Splicing - Major Pathway";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH1 Intracellular Domain Regulates Transcription";"NOTCH4 Intracellular Domain Regulates Transcription";"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"Notch-HLH transcription pathway";"RUNX3 regulates NOTCH signaling";"Pre-NOTCH Transcription and Translation";"NOTCH3 Intracellular Domain Regulates Transcription";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants"
Medex_00089169-RA	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
Medex_00092923-RA	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
Medex_00025105-RA	29	Reactome: R-HSA-6804756;KEGG: 04151+2.7.11.1;Reactome: R-HSA-5693579;Reactome: R-HSA-69473;Reactome: R-HSA-69541;KEGG: 05163+2.7.11.1;Reactome: R-HSA-5693565;Reactome: R-HSA-5693568;Reactome: R-HSA-6803204;Reactome: R-HSA-2559586;Reactome: R-HSA-3371453;KEGG: 04150+2.7.11.1;Reactome: R-HSA-5685938;Reactome: R-HSA-6804760;Reactome: R-HSA-5693607;Reactome: R-HSA-6803207;KEGG: 04714+2.7.11.1;Reactome: R-HSA-5693548;Reactome: R-HSA-6804757;Reactome: R-HSA-5693571;Reactome: R-HSA-6796648;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;Reactome: R-HSA-5685942;KEGG: 05170+2.7.11.1;Reactome: R-HSA-5693554;Reactome: R-HSA-912446;Reactome: R-HSA-349425;Reactome: R-HSA-5693616	"Regulation of TP53 Activity through Phosphorylation";"PI3K-Akt signaling pathway";"Homologous DNA Pairing and Strand Exchange";"G2/M DNA damage checkpoint";"Stabilization of p53";"Human cytomegalovirus infection";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Resolution of D-loop Structures through Holliday Junction Intermediates";"TP53 Regulates Transcription of Genes Involved in Cytochrome C Release";"DNA Damage/Telomere Stress Induced Senescence";"Regulation of HSF1-mediated heat shock response";"mTOR signaling pathway";"HDR through Single Strand Annealing (SSA)";"Regulation of TP53 Activity through Methylation";"Processing of DNA double-strand break ends";"TP53 Regulates Transcription of Caspase Activators and Caspases";"Thermogenesis";"Sensing of DNA Double Strand Breaks";"Regulation of TP53 Degradation";"Nonhomologous End-Joining (NHEJ)";"TP53 Regulates Transcription of DNA Repair Genes";"Relaxin signaling pathway";"Human papillomavirus infection";"HDR through Homologous Recombination (HRR)";"Human immunodeficiency virus 1 infection";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Meiotic recombination";"Autodegradation of the E3 ubiquitin ligase COP1";"Presynaptic phase of homologous DNA pairing and strand exchange"
Medex_00056420-RA	2	Reactome: R-HSA-383280;Reactome: R-HSA-4090294	"Nuclear Receptor transcription pathway";"SUMOylation of intracellular receptors"
Medex_00006857-RA	5	Reactome: R-HSA-2426168;Reactome: R-HSA-163765;Reactome: R-HSA-199220;Reactome: R-HSA-9029558;Reactome: R-HSA-75105	"Activation of gene expression by SREBF (SREBP)";"ChREBP activates metabolic gene expression";"Vitamin B5 (pantothenate) metabolism";"NR1H2 & NR1H3 regulate gene expression linked to lipogenesis";"Fatty acyl-CoA biosynthesis"
Medex_00041728-RA	1	KEGG: 00970+6.1.1.7	"Aminoacyl-tRNA biosynthesis"
Medex_00048538-RA	2	Reactome: R-HSA-4641262;Reactome: R-HSA-196299	"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"Beta-catenin phosphorylation cascade"
Medex_00002069-RA	1	KEGG: 00480+3.4.11.2	"Glutathione metabolism"
Medex_00003292-RA	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
Medex_00050759-RA	2	Reactome: R-HSA-1660662;Reactome: R-HSA-390471	"Glycosphingolipid metabolism";"Association of TriC/CCT with target proteins during biosynthesis"
Medex_00031495-RA	1	Reactome: R-HSA-8951664	"Neddylation"
Medex_00085591-RA	34	Reactome: R-HSA-3371453;Reactome: R-HSA-4615885;Reactome: R-HSA-5578749;Reactome: R-HSA-2500257;Reactome: R-HSA-168276;Reactome: R-HSA-165054;Reactome: R-HSA-180746;Reactome: R-HSA-9639288;Reactome: R-HSA-9609690;Reactome: R-HSA-9610379;Reactome: R-HSA-5619107;Reactome: R-HSA-159236;Reactome: R-HSA-3108214;Reactome: R-HSA-6784531;Reactome: R-HSA-3301854;Reactome: R-HSA-180910;Reactome: R-HSA-4570464;Reactome: R-HSA-4085377;Reactome: R-HSA-5663220;Reactome: R-HSA-159230;Reactome: R-HSA-1169408;Reactome: R-HSA-2467813;Reactome: R-HSA-168333;Reactome: R-HSA-159227;Reactome: R-HSA-9648025;Reactome: R-HSA-159231;Reactome: R-HSA-68877;Reactome: R-HSA-4551638;Reactome: R-HSA-168325;Reactome: R-HSA-191859;Reactome: R-HSA-141444;Reactome: R-HSA-3232142;Reactome: R-HSA-168271;Reactome: R-HSA-170822	"Regulation of HSF1-mediated heat shock response";"SUMOylation of DNA replication proteins";"Transcriptional regulation by small RNAs";"Resolution of Sister Chromatid Cohesion";"NS1 Mediated Effects on Host Pathways";"Rev-mediated nuclear export of HIV RNA";"Nuclear import of Rev protein";"Amino acids regulate mTORC1";"HCMV Early Events";"HCMV Late Events";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"SUMOylation of DNA damage response and repair proteins";"tRNA processing in the nucleus";"Nuclear Pore Complex (NPC) Disassembly";"Vpr-mediated nuclear import of PICs";"SUMOylation of RNA binding proteins";"SUMOylation of SUMOylation proteins";"RHO GTPases Activate Formins";"Transport of the SLBP Dependant Mature mRNA";"ISG15 antiviral mechanism";"Separation of Sister Chromatids";"NEP/NS2 Interacts with the Cellular Export Machinery";"Transport of the SLBP independent Mature mRNA";"EML4 and NUDC in mitotic spindle formation";"Transport of Mature mRNA Derived from an Intronless Transcript";"Mitotic Prometaphase";"SUMOylation of chromatin organization proteins";"Viral Messenger RNA Synthesis";"snRNP Assembly";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"SUMOylation of ubiquitinylation proteins";"Transport of Ribonucleoproteins into the Host Nucleus";"Regulation of Glucokinase by Glucokinase Regulatory Protein"
Medex_00005137-RA	6	Reactome: R-HSA-6803205;Reactome: R-HSA-139915;Reactome: R-HSA-6803207;Reactome: R-HSA-6803204;Reactome: R-HSA-6803211;Reactome: R-HSA-6804759	"TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain";"Activation of PUMA and translocation to mitochondria";"TP53 Regulates Transcription of Caspase Activators and Caspases";"TP53 Regulates Transcription of Genes Involved in Cytochrome C Release";"TP53 Regulates Transcription of Death Receptors and Ligands";"Regulation of TP53 Activity through Association with Co-factors"
Medex_00019847-RA	1	Reactome: R-HSA-606279	"Deposition of new CENPA-containing nucleosomes at the centromere"
Medex_00075357-RA	7	Reactome: R-HSA-380270;Reactome: R-HSA-380320;Reactome: R-HSA-8854518;Reactome: R-HSA-380259;Reactome: R-HSA-2565942;Reactome: R-HSA-380284;Reactome: R-HSA-5620912	"Recruitment of mitotic centrosome proteins and complexes";"Recruitment of NuMA to mitotic centrosomes";"AURKA Activation by TPX2";"Loss of Nlp from mitotic centrosomes";"Regulation of PLK1 Activity at G2/M Transition";"Loss of proteins required for interphase microtubule organization from the centrosome";"Anchoring of the basal body to the plasma membrane"
Medex_00014168-RA	3	KEGG: 00790+3.1.3.1;MetaCyc: PWY-5491;KEGG: 00730+3.1.3.1	"Folate biosynthesis";"Diethylphosphate degradation";"Thiamine metabolism"
Medex_00097369-RA	5	Reactome: R-HSA-2132295;Reactome: R-HSA-3371497;Reactome: R-HSA-6807878;Reactome: R-HSA-6811436;Reactome: R-HSA-983231	"MHC class II antigen presentation";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-mediated anterograde transport";"COPI-independent Golgi-to-ER retrograde traffic";"Factors involved in megakaryocyte development and platelet production"
Medex_00087006-RA	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
Medex_00027276-RA	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
Medex_00094896-RA	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
Medex_00092687-RA	2	KEGG: 00480+1.11.1.15;Reactome: R-HSA-3299685	"Glutathione metabolism";"Detoxification of Reactive Oxygen Species"
Medex_00023030-RA	3	Reactome: R-HSA-3000157;Reactome: R-HSA-8874081;Reactome: R-HSA-3000171	"Laminin interactions";"MET activates PTK2 signaling";"Non-integrin membrane-ECM interactions"
Medex_00003975-RA	6	Reactome: R-HSA-9640463;MetaCyc: PWY-5884;KEGG: 00073+1.2.1.84;MetaCyc: PWY-7782;MetaCyc: PWY-6733;MetaCyc: PWY-7656	"Wax biosynthesis";"Wax esters biosynthesis I";"Cutin, suberine and wax biosynthesis";"Plasmalogen biosynthesis";"Sporopollenin precursors biosynthesis";"Spodoptera littoralis pheromone biosynthesis"