Pathway_ID Pathway_Name Accession_Count Accessions Reactome: R-HSA-1660514 Synthesis of PIPs at the Golgi membrane 3 KOX79807.1;KOX70260.1;KOX76722.1 KEGG: 00230+6.3.3.1 Purine metabolism 1 KOX79954.1 MetaCyc: PWY-6538 Caffeine degradation III (bacteria, via demethylation) 1 KOX71781.1 KEGG: 00360+2.6.1.1 Phenylalanine metabolism 2 KOX71428.1;KOX79912.1 MetaCyc: PWY-5849 Menaquinol-6 biosynthesis 1 KOX75964.1 Reactome: R-HSA-2028269 Signaling by Hippo 3 KOX72201.1;KOX77898.1;KOX70304.1 KEGG: 00410+1.3.3.6 beta-Alanine metabolism 2 KOX71616.1;KOX73119.1 Reactome: R-HSA-977347 Serine biosynthesis 3 KOX78938.1;KOX78490.1;KOX74576.1 Reactome: R-HSA-163754 Insulin effects increased synthesis of Xylulose-5-Phosphate 1 KOX67931.1 Reactome: R-HSA-162699 Synthesis of dolichyl-phosphate mannose 3 KOX72243.1;KOX73553.1;KOX78339.1 Reactome: R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 21 KOX68522.1;KOX72221.1;KOX79433.1;KOX74217.1;KOX67692.1;KOX80977.1;KOX74214.1;KOX74812.1;KOX80895.1;KOX68199.1;KOX77330.1;KOX67229.1;KOX76343.1;KOX72105.1;KOX71786.1;KOX74854.1;KOX68054.1;KOX79430.1;KOX71763.1;KOX68243.1;KOX79065.1 MetaCyc: PWY-7003 Glycerol degradation to butanol 7 KOX74974.1;KOX81104.1;KOX74975.1;KOX71859.1;KOX67203.1;KOX67171.1;KOX72508.1 KEGG: 00330+2.5.1.16 Arginine and proline metabolism 2 KOX80905.1;KOX74762.1 Reactome: R-HSA-380994 ATF4 activates genes in response to endoplasmic reticulum stress 15 KOX77527.1;KOX79092.1;KOX68794.1;KOX68192.1;KOX69818.1;KOX70791.1;KOX70145.1;KOX77410.1;KOX73868.1;KOX69500.1;KOX76988.1;KOX68469.1;KOX79938.1;KOX71022.1;KOX71950.1 KEGG: 00380+4.2.1.17 Tryptophan metabolism 1 KOX76405.1 KEGG: 00430+2.3.2.2 Taurine and hypotaurine metabolism 3 KOX79924.1;KOX71346.1;KOX78785.1 KEGG: 00534+2.4.2.26 Glycosaminoglycan biosynthesis - heparan sulfate / heparin 1 KOX79480.1 KEGG: 00680+5.4.2.11 Methane metabolism 1 KOX73085.1 MetaCyc: PWY-4702 Phytate degradation I 3 KOX71857.1;KOX75546.1;KOX75545.1 Reactome: R-HSA-9652282 Drug-mediated inhibition of ERBB2 signaling 1 KOX73791.1 Reactome: R-HSA-168638 NOD1/2 Signaling Pathway 6 KOX79430.1;KOX79433.1;KOX72105.1;KOX75998.1;KOX71145.1;KOX67229.1 Reactome: R-HSA-429947 Deadenylation of mRNA 11 KOX77527.1;KOX68213.1;KOX75402.1;KOX67191.1;KOX70612.1;KOX69831.1;KOX77625.1;KOX71508.1;KOX77546.1;KOX76808.1;KOX72780.1 MetaCyc: PWY-5744 Glyoxylate assimilation 5 KOX68087.1;KOX68932.1;KOX79144.1;KOX70011.1;KOX80775.1 KEGG: 00620+4.4.1.5 Pyruvate metabolism 1 KOX73783.1 KEGG: 00623+1.1.1.35 Toluene degradation 2 KOX76405.1;KOX75101.1 Reactome: R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome 42 KOX70598.1;KOX68314.1;KOX72411.1;KOX78266.1;KOX76879.1;KOX79430.1;KOX73060.1;KOX67229.1;KOX76416.1;KOX70009.1;KOX76009.1;KOX80582.1;KOX71606.1;KOX78268.1;KOX72468.1;KOX73209.1;KOX74011.1;KOX69688.1;KOX79433.1;KOX74924.1;KOX74910.1;KOX75984.1;KOX79230.1;KOX72105.1;KOX70419.1;KOX79601.1;KOX70383.1;KOX68313.1;KOX78786.1;KOX72982.1;KOX79363.1;KOX77271.1;KOX75968.1;KOX70760.1;KOX72837.1;KOX80008.1;KOX79626.1;KOX69414.1;KOX74139.1;KOX78273.1;KOX69333.1;KOX68748.1 KEGG: 00860+1.14.14.18 Porphyrin and chlorophyll metabolism 1 KOX70144.1 Reactome: R-HSA-442982 Ras activation upon Ca2+ influx through NMDA receptor 4 KOX69097.1;KOX68226.1;KOX78706.1;KOX68537.1 Reactome: R-HSA-8964208 Phenylalanine metabolism 2 KOX72380.1;KOX77562.1 Reactome: R-HSA-391160 Signal regulatory protein family interactions 2 KOX81204.1;KOX72079.1 MetaCyc: PWY-4361 S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I 5 KOX72835.1;KOX73121.1;KOX72189.1;KOX70443.1;KOX79884.1 Reactome: R-HSA-4570571 Defective RFT1 causes RFT1-CDG (CDG-1n) 1 KOX73088.1 Reactome: R-HSA-5657562 Essential fructosuria 1 KOX79350.1 Reactome: R-HSA-417973 Adenosine P1 receptors 1 KOX68503.1 KEGG: 00410+2.6.1.19 beta-Alanine metabolism 1 KOX75380.1 Reactome: R-HSA-2022854 Keratan sulfate biosynthesis 4 KOX70844.1;KOX80037.1;KOX69179.1;KOX76870.1 MetaCyc: PWY-6906 Chitin derivatives degradation 5 KOX72719.1;KOX67942.1;KOX77757.1;KOX74440.1;KOX81368.1 MetaCyc: PWY-882 L-ascorbate biosynthesis I (L-galactose pathway) 2 KOX72772.1;KOX74805.1 Reactome: R-HSA-2586552 Signaling by Leptin 1 KOX69723.1 MetaCyc: PWY-5123 Trans, trans-farnesyl diphosphate biosynthesis 2 KOX72808.1;KOX74855.1 Reactome: R-HSA-5655302 Signaling by FGFR1 in disease 2 KOX81204.1;KOX68654.1 Reactome: R-HSA-203927 MicroRNA (miRNA) biogenesis 17 KOX74828.1;KOX77062.1;KOX68839.1;KOX67889.1;KOX79649.1;KOX79264.1;KOX68332.1;KOX71635.1;KOX73198.1;KOX81203.1;KOX70166.1;KOX77063.1;KOX70787.1;KOX67200.1;KOX68731.1;KOX70044.1;KOX77626.1 MetaCyc: PWY-7340 9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast) 2 KOX73119.1;KOX71616.1 Reactome: R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 45 KOX79436.1;KOX72429.1;KOX73449.1;KOX75539.1;KOX74745.1;KOX72473.1;KOX69061.1;KOX73226.1;KOX80386.1;KOX77058.1;KOX79860.1;KOX79897.1;KOX73274.1;KOX73851.1;KOX78666.1;KOX79242.1;KOX71605.1;KOX74624.1;KOX68874.1;KOX75540.1;KOX74188.1;KOX72220.1;KOX75630.1;KOX73304.1;KOX72752.1;KOX80793.1;KOX68477.1;KOX74386.1;KOX68575.1;KOX68732.1;KOX80341.1;KOX78183.1;KOX68896.1;KOX73131.1;KOX71437.1;KOX77767.1;KOX75816.1;KOX72920.1;KOX74908.1;KOX73664.1;KOX77505.1;KOX75811.1;KOX81376.1;KOX75336.1;KOX74909.1 Reactome: R-HSA-167243 Tat-mediated HIV elongation arrest and recovery 23 KOX75987.1;KOX71506.1;KOX79649.1;KOX77062.1;KOX80159.1;KOX74806.1;KOX70044.1;KOX77626.1;KOX78553.1;KOX81395.1;KOX72082.1;KOX67200.1;KOX77418.1;KOX74945.1;KOX70730.1;KOX68573.1;KOX69424.1;KOX77063.1;KOX67622.1;KOX73198.1;KOX78696.1;KOX67799.1;KOX81203.1 Reactome: R-HSA-975155 MyD88 dependent cascade initiated on endosome 1 KOX68497.1 KEGG: 00564+2.7.8.5 Glycerophospholipid metabolism 1 KOX67809.1 KEGG: 00260+2.1.2.10 Glycine, serine and threonine metabolism 4 KOX74361.1;KOX79396.1;KOX71509.1;KOX67693.1 KEGG: 00710+2.7.2.3 Carbon fixation in photosynthetic organisms 1 KOX67203.1 MetaCyc: PWY-7286 7-(3-amino-3-carboxypropyl)-wyosine biosynthesis 2 KOX72874.1;KOX67520.1 KEGG: 00561+2.3.1.15 Glycerolipid metabolism 2 KOX80280.1;KOX76514.1 Reactome: R-HSA-9645722 Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function 1 KOX70403.1 Reactome: R-HSA-110314 Recognition of DNA damage by PCNA-containing replication complex 23 KOX79548.1;KOX70085.1;KOX77830.1;KOX71193.1;KOX78024.1;KOX74923.1;KOX77356.1;KOX79433.1;KOX73258.1;KOX81364.1;KOX71452.1;KOX71969.1;KOX79430.1;KOX72105.1;KOX70402.1;KOX77276.1;KOX67310.1;KOX77326.1;KOX70388.1;KOX73285.1;KOX67229.1;KOX70673.1;KOX72417.1 KEGG: 00281+4.2.1.17 Geraniol degradation 1 KOX76405.1 KEGG: 00052+3.2.1.23 Galactose metabolism 3 KOX77035.1;KOX75741.1;KOX80383.1 MetaCyc: PWY-6946 Cholesterol degradation to androstenedione II (cholesterol dehydrogenase) 2 KOX75101.1;KOX76405.1 Reactome: R-HSA-8964616 G beta:gamma signalling through CDC42 7 KOX78779.1;KOX79656.1;KOX78343.1;KOX69081.1;KOX76191.1;KOX79467.1;KOX76508.1 Reactome: R-HSA-354194 GRB2:SOS provides linkage to MAPK signaling for Integrins 1 KOX81204.1 Reactome: R-HSA-73776 RNA Polymerase II Promoter Escape 29 KOX77907.1;KOX73785.1;KOX71363.1;KOX79649.1;KOX78263.1;KOX72538.1;KOX81403.1;KOX77062.1;KOX68559.1;KOX69897.1;KOX69085.1;KOX74806.1;KOX74930.1;KOX77334.1;KOX68729.1;KOX77626.1;KOX70044.1;KOX69540.1;KOX74030.1;KOX71518.1;KOX77418.1;KOX71842.1;KOX67200.1;KOX81398.1;KOX74919.1;KOX69719.1;KOX77063.1;KOX81203.1;KOX73198.1 MetaCyc: PWY-7035 (9Z)-tricosene biosynthesis 21 KOX78654.1;KOX77795.1;KOX67350.1;KOX68696.1;KOX67486.1;KOX79701.1;KOX78657.1;KOX78662.1;KOX78650.1;KOX74597.1;KOX68278.1;KOX78653.1;KOX73201.1;KOX68279.1;KOX78713.1;KOX78236.1;KOX80068.1;KOX78651.1;KOX78660.1;KOX75202.1;KOX78659.1 Reactome: R-HSA-190873 Gap junction degradation 3 KOX70039.1;KOX69299.1;KOX76831.1 Reactome: R-HSA-1268020 Mitochondrial protein import 36 KOX67167.1;KOX79397.1;KOX76358.1;KOX78094.1;KOX80572.1;KOX78768.1;KOX75544.1;KOX77380.1;KOX79257.1;KOX80877.1;KOX80004.1;KOX71536.1;KOX75279.1;KOX74208.1;KOX79538.1;KOX80228.1;KOX73634.1;KOX79809.1;KOX67854.1;KOX74466.1;KOX70999.1;KOX67701.1;KOX79208.1;KOX75672.1;KOX72987.1;KOX78342.1;KOX74978.1;KOX70533.1;KOX77776.1;KOX72479.1;KOX73806.1;KOX75400.1;KOX76663.1;KOX80748.1;KOX74235.1;KOX73385.1 MetaCyc: PWY-7328 Superpathway of UDP-glucose-derived O-antigen building blocks biosynthesis 2 KOX72084.1;KOX77926.1 KEGG: 00710+4.1.2.13 Carbon fixation in photosynthetic organisms 2 KOX76362.1;KOX76361.1 KEGG: 04070+2.7.11.13 Phosphatidylinositol signaling system 4 KOX76512.1;KOX77703.1;KOX79275.1;KOX77054.1 Reactome: R-HSA-375276 Peptide ligand-binding receptors 7 KOX71113.1;KOX68412.1;KOX70895.1;KOX71542.1;KOX70896.1;KOX69287.1;KOX75256.1 KEGG: 00010+3.1.3.11 Glycolysis / Gluconeogenesis 1 KOX68814.1 MetaCyc: PWY-7979 Protein O-mannosylation III (mammals, core M3) 6 KOX72243.1;KOX77837.1;KOX81252.1;KOX70674.1;KOX72250.1;KOX71057.1 KEGG: 00680+3.1.2.12 Methane metabolism 1 KOX75486.1 Reactome: R-HSA-1566948 Elastic fibre formation 1 KOX72728.1 Reactome: R-HSA-5654710 PI-3K cascade:FGFR3 1 KOX81204.1 Reactome: R-HSA-4086400 PCP/CE pathway 2 KOX80053.1;KOX71684.1 KEGG: 00720+1.3.5.1 Carbon fixation pathways in prokaryotes 2 KOX79955.1;KOX68680.1 Reactome: R-HSA-392851 Prostacyclin signalling through prostacyclin receptor 5 KOX79467.1;KOX76508.1;KOX78343.1;KOX79656.1;KOX69081.1 Reactome: R-HSA-9649948 Signaling downstream of RAS mutants 5 KOX68226.1;KOX79918.1;KOX68521.1;KOX80917.1;KOX68500.1 MetaCyc: PWY-6580 Phosphatidylinositol biosynthesis I (bacteria) 2 KOX71993.1;KOX68055.1 KEGG: 00511+3.2.1.52 Other glycan degradation 4 KOX74395.1;KOX74285.1;KOX74631.1;KOX73530.1 MetaCyc: PWY-7654 (8E,10E)-dodeca-8,10-dienol biosynthesis 2 KOX76405.1;KOX75101.1 Reactome: R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 6 KOX73944.1;KOX79264.1;KOX70581.1;KOX73423.1;KOX74490.1;KOX74595.1 Reactome: R-HSA-70370 Galactose catabolism 2 KOX72084.1;KOX77926.1 KEGG: 00230+3.5.4.4 Purine metabolism 1 KOX71685.1 MetaCyc: PWY-7536 2-amino-3-hydroxycyclopent-2-enone biosynthesis 1 KOX74171.1 MetaCyc: PWY-7346 UDP-alpha-D-glucuronate biosynthesis (from UDP-glucose) 1 KOX69806.1 Reactome: R-HSA-400206 Regulation of lipid metabolism by PPARalpha 5 KOX74904.1;KOX68963.1;KOX71680.1;KOX78052.1;KOX76309.1 KEGG: 00524+2.7.1.1 Neomycin, kanamycin and gentamicin biosynthesis 2 KOX72065.1;KOX80688.1 KEGG: 00510+2.7.8.15 N-Glycan biosynthesis 1 KOX77790.1 Reactome: R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome 17 KOX73600.1;KOX71404.1;KOX69877.1;KOX75429.1;KOX76312.1;KOX76822.1;KOX72931.1;KOX68021.1;KOX70798.1;KOX69780.1;KOX75559.1;KOX73591.1;KOX79004.1;KOX78488.1;KOX75516.1;KOX75699.1;KOX80122.1 KEGG: 00983+2.4.2.10 Drug metabolism - other enzymes 1 KOX71473.1 Reactome: R-HSA-6782135 Dual incision in TC-NER 45 KOX77062.1;KOX71452.1;KOX81364.1;KOX77356.1;KOX79433.1;KOX73785.1;KOX78024.1;KOX69032.1;KOX74923.1;KOX77830.1;KOX79649.1;KOX70673.1;KOX67229.1;KOX69719.1;KOX74919.1;KOX71018.1;KOX81203.1;KOX78035.1;KOX77020.1;KOX77023.1;KOX74030.1;KOX67200.1;KOX68485.1;KOX79430.1;KOX69897.1;KOX81403.1;KOX71969.1;KOX71193.1;KOX72538.1;KOX79548.1;KOX77063.1;KOX72417.1;KOX72862.1;KOX73198.1;KOX70388.1;KOX73285.1;KOX77626.1;KOX67310.1;KOX77326.1;KOX69540.1;KOX70044.1;KOX70402.1;KOX77276.1;KOX78784.1;KOX72105.1 KEGG: 00515+2.4.1.109 Mannose type O-glycan biosynthesis 5 KOX72250.1;KOX71057.1;KOX70674.1;KOX77837.1;KOX81252.1 Reactome: R-HSA-8964315 G beta:gamma signalling through BTK 5 KOX76508.1;KOX79467.1;KOX78343.1;KOX79656.1;KOX69081.1 Reactome: R-HSA-376172 DSCAM interactions 1 KOX71145.1 Reactome: R-HSA-422356 Regulation of insulin secretion 2 KOX74139.1;KOX73812.1 KEGG: 00195+7.1.2.2 Photosynthesis 4 KOX79538.1;KOX72760.1;KOX78342.1;KOX73541.1 Reactome: R-HSA-418217 G beta:gamma signalling through PLC beta 6 KOX75330.1;KOX76508.1;KOX79467.1;KOX78343.1;KOX79656.1;KOX69081.1 Reactome: R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures 5 KOX75715.1;KOX74957.1;KOX75660.1;KOX75720.1;KOX76649.1 Reactome: R-HSA-9615017 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 4 KOX68841.1;KOX67775.1;KOX71680.1;KOX76704.1 MetaCyc: PWY-5895 Menaquinol-13 biosynthesis 1 KOX75964.1 Reactome: R-HSA-4641265 Repression of WNT target genes 3 KOX76731.1;KOX67626.1;KOX78528.1 Reactome: R-HSA-9664565 Signaling by ERBB2 KD Mutants 3 KOX72629.1;KOX73791.1;KOX81204.1 Reactome: R-HSA-392517 Rap1 signalling 2 KOX74139.1;KOX72584.1 KEGG: 00480+4.3.2.9 Glutathione metabolism 1 KOX74355.1 Reactome: R-HSA-8875555 MET activates RAP1 and RAC1 2 KOX81245.1;KOX81204.1 KEGG: 00562+3.1.3.64 Inositol phosphate metabolism 1 KOX71993.1 KEGG: 00730+2.7.6.2 Thiamine metabolism 1 KOX78326.1 KEGG: 00680+1.1.1.284 Methane metabolism 1 KOX67600.1 MetaCyc: PWY-5340 Sulfate activation for sulfonation 2 KOX68057.1;KOX74601.1 KEGG: 00380+1.11.1.6 Tryptophan metabolism 1 KOX76704.1 KEGG: 00230+2.4.2.1 Purine metabolism 1 KOX78203.1 Reactome: R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER 43 KOX72105.1;KOX67310.1;KOX77626.1;KOX77326.1;KOX70044.1;KOX69540.1;KOX77276.1;KOX70402.1;KOX73198.1;KOX70388.1;KOX73285.1;KOX77063.1;KOX72417.1;KOX72538.1;KOX79548.1;KOX71193.1;KOX69897.1;KOX81403.1;KOX71969.1;KOX67200.1;KOX68485.1;KOX79430.1;KOX77020.1;KOX74030.1;KOX77023.1;KOX71018.1;KOX81203.1;KOX78035.1;KOX67229.1;KOX70673.1;KOX74919.1;KOX69719.1;KOX77830.1;KOX79649.1;KOX73785.1;KOX78024.1;KOX69032.1;KOX74923.1;KOX81364.1;KOX77356.1;KOX79433.1;KOX77062.1;KOX71452.1 Reactome: R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 12 KOX74580.1;KOX71680.1;KOX67748.1;KOX73641.1;KOX74214.1;KOX74484.1;KOX70201.1;KOX72851.1;KOX74217.1;KOX77330.1;KOX75454.1;KOX79878.1 Reactome: R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 59 KOX67635.1;KOX73197.1;KOX78531.1;KOX69778.1;KOX68474.1;KOX75609.1;KOX69007.1;KOX77793.1;KOX72164.1;KOX68746.1;KOX70429.1;KOX72161.1;KOX72163.1;KOX71890.1;KOX74219.1;KOX78803.1;KOX69879.1;KOX70129.1;KOX72162.1;KOX73046.1;KOX70569.1;KOX68210.1;KOX78032.1;KOX77052.1;KOX72302.1;KOX79744.1;KOX70769.1;KOX75484.1;KOX72450.1;KOX79174.1;KOX75272.1;KOX71175.1;KOX79067.1;KOX75785.1;KOX71096.1;KOX72556.1;KOX80291.1;KOX73974.1;KOX79066.1;KOX72843.1;KOX78689.1;KOX78668.1;KOX77419.1;KOX68198.1;KOX73744.1;KOX73748.1;KOX77968.1;KOX67776.1;KOX72895.1;KOX74885.1;KOX74799.1;KOX71286.1;KOX79827.1;KOX70983.1;KOX75646.1;KOX67801.1;KOX75530.1;KOX74480.1;KOX78475.1 Reactome: R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic 26 KOX75211.1;KOX78693.1;KOX69879.1;KOX70129.1;KOX72162.1;KOX72469.1;KOX72895.1;KOX75272.1;KOX75989.1;KOX79174.1;KOX75516.1;KOX79744.1;KOX71735.1;KOX72302.1;KOX80782.1;KOX72163.1;KOX72161.1;KOX72021.1;KOX68241.1;KOX75429.1;KOX72843.1;KOX71404.1;KOX77793.1;KOX68198.1;KOX72164.1;KOX69877.1 KEGG: 00240+1.17.4.1 Pyrimidine metabolism 1 KOX79885.1 KEGG: 00920+2.7.1.25 Sulfur metabolism 2 KOX68057.1;KOX74601.1 Reactome: R-HSA-8964026 Chylomicron clearance 5 KOX73976.1;KOX69335.1;KOX68248.1;KOX73997.1;KOX80996.1 KEGG: 00510+2.4.1.144 N-Glycan biosynthesis 1 KOX77791.1 Reactome: R-HSA-165181 Inhibition of TSC complex formation by PKB 2 KOX80745.1;KOX69422.1 MetaCyc: PWY-5078 L-isoleucine degradation II 2 KOX72274.1;KOX67600.1 Reactome: R-HSA-4085377 SUMOylation of SUMOylation proteins 20 KOX72429.1;KOX75539.1;KOX75630.1;KOX80793.1;KOX79436.1;KOX80341.1;KOX73226.1;KOX68732.1;KOX78183.1;KOX72473.1;KOX69061.1;KOX73664.1;KOX77505.1;KOX73131.1;KOX77058.1;KOX75540.1;KOX79242.1;KOX68874.1;KOX75811.1;KOX81376.1 Reactome: R-HSA-5654726 Negative regulation of FGFR1 signaling 7 KOX81204.1;KOX77425.1;KOX68500.1;KOX67229.1;KOX79430.1;KOX79433.1;KOX72105.1 MetaCyc: PWY-6840 Homoglutathione biosynthesis 1 KOX78147.1 Reactome: R-HSA-5696395 Formation of Incision Complex in GG-NER 21 KOX69897.1;KOX73447.1;KOX81403.1;KOX79433.1;KOX73785.1;KOX71193.1;KOX72538.1;KOX78340.1;KOX72417.1;KOX72862.1;KOX67229.1;KOX69719.1;KOX74919.1;KOX70388.1;KOX69540.1;KOX77633.1;KOX74030.1;KOX70402.1;KOX78784.1;KOX72105.1;KOX79430.1 MetaCyc: PWY-8004 Entner-Doudoroff pathway I 9 KOX71859.1;KOX73085.1;KOX73807.1;KOX74975.1;KOX81368.1;KOX67203.1;KOX81104.1;KOX74974.1;KOX72508.1 Reactome: R-HSA-430039 mRNA decay by 5' to 3' exoribonuclease 7 KOX79307.1;KOX70145.1;KOX69302.1;KOX75605.1;KOX78415.1;KOX71743.1;KOX78200.1 KEGG: 00020+1.1.1.37 Citrate cycle (TCA cycle) 5 KOX75374.1;KOX68928.1;KOX70049.1;KOX69541.1;KOX70050.1 Reactome: R-HSA-379726 Mitochondrial tRNA aminoacylation 9 KOX71409.1;KOX71744.1;KOX79232.1;KOX74356.1;KOX71972.1;KOX72739.1;KOX68068.1;KOX72994.1;KOX72180.1 KEGG: 00281+4.2.1.17+1.1.1.35 Geraniol degradation 2 KOX75101.1;KOX76405.1 Reactome: R-HSA-68689 CDC6 association with the ORC:origin complex 6 KOX73262.1;KOX67686.1;KOX69890.1;KOX76415.1;KOX70456.1;KOX79615.1 MetaCyc: PWY-7119 Ceramide and sphingolipid recycling and degradation (yeast) 2 KOX71112.1;KOX71109.1 Reactome: R-HSA-72165 mRNA Splicing - Minor Pathway 31 KOX79649.1;KOX68671.1;KOX73321.1;KOX74909.1;KOX76265.1;KOX79897.1;KOX74806.1;KOX78050.1;KOX70374.1;KOX74908.1;KOX69307.1;KOX77062.1;KOX68967.1;KOX67200.1;KOX77418.1;KOX70044.1;KOX74267.1;KOX77626.1;KOX80507.1;KOX78510.1;KOX68675.1;KOX67590.1;KOX74386.1;KOX78065.1;KOX73198.1;KOX80923.1;KOX81203.1;KOX78200.1;KOX72432.1;KOX77063.1;KOX75692.1 KEGG: 00020+2.3.1.12 Citrate cycle (TCA cycle) 1 KOX79834.1 KEGG: 00520+2.4.1.16 Amino sugar and nucleotide sugar metabolism 2 KOX80907.1;KOX68961.1 MetaCyc: PWY-7728 (4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase) 2 KOX79701.1;KOX78236.1 Reactome: R-HSA-428930 Thromboxane signalling through TP receptor 6 KOX67567.1;KOX79656.1;KOX69081.1;KOX78343.1;KOX76508.1;KOX79467.1 Reactome: R-HSA-3214815 HDACs deacetylate histones 11 KOX74217.1;KOX72040.1;KOX77330.1;KOX71951.1;KOX71059.1;KOX70373.1;KOX74214.1;KOX81302.1;KOX74673.1;KOX77394.1;KOX77031.1 KEGG: 00230+3.5.4.6 Purine metabolism 1 KOX74844.1 MetaCyc: PWY-5523 5,6-dimethylbenzimidazole biosynthesis I (aerobic) 1 KOX78122.1 Reactome: R-HSA-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER 19 KOX77830.1;KOX79548.1;KOX74923.1;KOX78024.1;KOX81364.1;KOX79433.1;KOX77356.1;KOX71969.1;KOX71452.1;KOX72105.1;KOX79430.1;KOX67310.1;KOX77326.1;KOX77276.1;KOX70402.1;KOX73285.1;KOX72417.1;KOX70673.1;KOX67229.1 MetaCyc: PWY-5122 Geranyl diphosphate biosynthesis 1 KOX72808.1 MetaCyc: PWY-7254 TCA cycle VII (acetate-producers) 4 KOX79046.1;KOX79955.1;KOX68680.1;KOX77859.1 KEGG: 00520+5.3.1.9 Amino sugar and nucleotide sugar metabolism 1 KOX67919.1 MetaCyc: PWY-7851 Coenzyme A biosynthesis II (eukaryotic) 2 KOX69837.1;KOX70265.1 MetaCyc: PWY-3781 Aerobic respiration I (cytochrome c) 3 KOX68680.1;KOX76195.1;KOX79955.1 Reactome: R-HSA-69202 Cyclin E associated events during G1/S transition 8 KOX72400.1;KOX73662.1;KOX72538.1;KOX80899.1;KOX70592.1;KOX81403.1;KOX74615.1;KOX68519.1 KEGG: 00130+1.14.99.60 Ubiquinone and other terpenoid-quinone biosynthesis 1 KOX70323.1 Reactome: R-HSA-532668 N-glycan trimming in the ER and Calnexin/Calreticulin cycle 12 KOX79433.1;KOX69658.1;KOX78325.1;KOX70383.1;KOX72129.1;KOX67229.1;KOX72105.1;KOX75820.1;KOX79430.1;KOX68878.1;KOX75409.1;KOX72748.1 MetaCyc: PWY-7901 Glucosinolate biosynthesis from tyrosine 1 KOX80071.1 Reactome: R-HSA-9010553 Regulation of expression of SLITs and ROBOs 126 KOX72644.1;KOX74668.1;KOX67280.1;KOX80772.1;KOX72105.1;KOX77134.1;KOX73982.1;KOX81388.1;KOX70383.1;KOX74407.1;KOX68313.1;KOX79914.1;KOX74170.1;KOX69807.1;KOX79363.1;KOX75968.1;KOX70760.1;KOX77911.1;KOX74637.1;KOX68431.1;KOX71605.1;KOX71988.1;KOX81215.1;KOX78350.1;KOX72660.1;KOX72185.1;KOX76065.1;KOX75483.1;KOX71077.1;KOX69333.1;KOX68748.1;KOX75797.1;KOX74357.1;KOX75024.1;KOX71651.1;KOX75227.1;KOX80864.1;KOX78266.1;KOX77016.1;KOX72082.1;KOX73344.1;KOX79160.1;KOX68575.1;KOX73060.1;KOX76416.1;KOX67361.1;KOX75336.1;KOX75432.1;KOX74909.1;KOX75945.1;KOX72125.1;KOX72904.1;KOX67237.1;KOX78268.1;KOX70024.1;KOX74908.1;KOX79433.1;KOX79738.1;KOX74910.1;KOX75984.1;KOX76900.1;KOX78568.1;KOX78826.1;KOX74044.1;KOX73120.1;KOX79230.1;KOX70419.1;KOX79601.1;KOX78116.1;KOX67227.1;KOX78786.1;KOX77318.1;KOX72982.1;KOX73889.1;KOX67622.1;KOX77319.1;KOX77271.1;KOX78289.1;KOX74804.1;KOX73450.1;KOX80008.1;KOX68042.1;KOX79626.1;KOX69414.1;KOX78273.1;KOX78670.1;KOX70874.1;KOX75358.1;KOX68744.1;KOX68107.1;KOX79860.1;KOX70598.1;KOX68314.1;KOX72411.1;KOX79611.1;KOX72330.1;KOX76879.1;KOX67698.1;KOX70147.1;KOX67935.1;KOX79430.1;KOX81212.1;KOX69831.1;KOX67699.1;KOX75143.1;KOX71403.1;KOX67229.1;KOX77188.1;KOX70009.1;KOX70176.1;KOX76009.1;KOX80582.1;KOX71394.1;KOX70724.1;KOX78800.1;KOX71606.1;KOX67795.1;KOX71471.1;KOX72468.1;KOX73209.1;KOX74011.1;KOX73308.1;KOX74924.1;KOX72074.1;KOX67807.1;KOX75958.1 Reactome: R-HSA-69183 Processive synthesis on the lagging strand 9 KOX81161.1;KOX78132.1;KOX79678.1;KOX78863.1;KOX77356.1;KOX81364.1;KOX77326.1;KOX78024.1;KOX69330.1 KEGG: 00480+2.5.1.22 Glutathione metabolism 1 KOX80905.1 Reactome: R-HSA-163767 PP2A-mediated dephosphorylation of key metabolic factors 1 KOX76312.1 KEGG: 00020+4.2.1.3 Citrate cycle (TCA cycle) 2 KOX71536.1;KOX73090.1 Reactome: R-HSA-2514859 Inactivation, recovery and regulation of the phototransduction cascade 5 KOX79589.1;KOX79810.1;KOX72173.1;KOX75083.1;KOX71937.1 KEGG: 00040+2.7.1.17 Pentose and glucuronate interconversions 1 KOX73255.1 Reactome: R-HSA-5626467 RHO GTPases activate IQGAPs 19 KOX72153.1;KOX72843.1;KOX77793.1;KOX72164.1;KOX68198.1;KOX72161.1;KOX74201.1;KOX76191.1;KOX72163.1;KOX68498.1;KOX72895.1;KOX69879.1;KOX72162.1;KOX70129.1;KOX72302.1;KOX78779.1;KOX79744.1;KOX79174.1;KOX75272.1 Reactome: R-HSA-174048 APC/C:Cdc20 mediated degradation of Cyclin B 13 KOX76210.1;KOX79433.1;KOX74256.1;KOX72749.1;KOX76684.1;KOX67229.1;KOX79389.1;KOX72105.1;KOX79430.1;KOX71898.1;KOX73267.1;KOX71992.1;KOX72154.1 Reactome: R-HSA-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 4 KOX80899.1;KOX70054.1;KOX74904.1;KOX78024.1 Reactome: R-HSA-6798163 Choline catabolism 26 KOX71152.1;KOX80306.1;KOX76352.1;KOX80330.1;KOX67667.1;KOX80305.1;KOX67656.1;KOX67443.1;KOX69471.1;KOX69462.1;KOX71154.1;KOX69888.1;KOX67655.1;KOX67295.1;KOX71155.1;KOX67574.1;KOX67282.1;KOX70118.1;KOX68393.1;KOX78880.1;KOX69466.1;KOX67668.1;KOX78881.1;KOX71153.1;KOX71151.1;KOX80331.1 Reactome: R-HSA-4720454 Defective ALG9 causes ALG9-CDG (CDG-1l) 1 KOX76984.1 Reactome: R-HSA-5662702 Melanin biosynthesis 6 KOX67352.1;KOX79856.1;KOX67354.1;KOX79496.1;KOX67353.1;KOX78697.1 KEGG: 00640+6.2.1.5 Propanoate metabolism 4 KOX79892.1;KOX79891.1;KOX79460.1;KOX74316.1 KEGG: 00860+2.3.1.37 Porphyrin and chlorophyll metabolism 1 KOX74171.1 Reactome: R-HSA-164843 2-LTR circle formation 4 KOX73082.1;KOX77101.1;KOX71648.1;KOX72766.1 Reactome: R-HSA-5686938 Regulation of TLR by endogenous ligand 5 KOX68248.1;KOX80996.1;KOX73997.1;KOX73976.1;KOX69335.1 Reactome: R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins 10 KOX79467.1;KOX73149.1;KOX78343.1;KOX69402.1;KOX74139.1;KOX76508.1;KOX79656.1;KOX78138.1;KOX71184.1;KOX69081.1 KEGG: 00604+3.2.1.52 Glycosphingolipid biosynthesis - ganglio series 4 KOX73530.1;KOX74631.1;KOX74285.1;KOX74395.1 Reactome: R-HSA-201688 WNT mediated activation of DVL 2 KOX79369.1;KOX71684.1 Reactome: R-HSA-111457 Release of apoptotic factors from the mitochondria 4 KOX78217.1;KOX69899.1;KOX78094.1;KOX69910.1 KEGG: 00950+2.6.1.1 Isoquinoline alkaloid biosynthesis 2 KOX79912.1;KOX71428.1 MetaCyc: PWY-7909 Formaldehyde oxidation VII (THF pathway) 2 KOX67514.1;KOX77269.1 Reactome: R-HSA-6782861 Synthesis of wybutosine at G37 of tRNA(Phe) 1 KOX68032.1 Reactome: R-HSA-68867 Assembly of the pre-replicative complex 15 KOX69890.1;KOX76415.1;KOX81352.1;KOX76493.1;KOX79615.1;KOX69273.1;KOX72070.1;KOX70456.1;KOX67686.1;KOX70391.1;KOX73022.1;KOX70033.1;KOX73262.1;KOX74494.1;KOX68806.1 KEGG: 00720+1.5.1.20 Carbon fixation pathways in prokaryotes 1 KOX72989.1 MetaCyc: PWY-5989 Stearate biosynthesis II (bacteria and plants) 2 KOX73549.1;KOX69550.1 MetaCyc: PWY-6964 Ammonia assimilation cycle II 1 KOX75490.1 KEGG: 04070+2.7.7.41 Phosphatidylinositol signaling system 2 KOX68030.1;KOX67877.1 KEGG: 04150+2.7.11.1 mTOR signaling pathway 40 KOX77898.1;KOX79675.1;KOX70861.1;KOX72201.1;KOX74186.1;KOX79817.1;KOX69619.1;KOX68054.1;KOX71579.1;KOX77364.1;KOX78841.1;KOX76214.1;KOX81246.1;KOX74477.1;KOX68647.1;KOX78509.1;KOX69995.1;KOX79225.1;KOX72400.1;KOX73463.1;KOX70676.1;KOX79935.1;KOX76221.1;KOX70561.1;KOX77803.1;KOX68566.1;KOX79039.1;KOX79033.1;KOX77506.1;KOX68521.1;KOX74479.1;KOX68084.1;KOX73800.1;KOX68654.1;KOX73724.1;KOX79522.1;KOX78362.1;KOX71595.1;KOX79166.1;KOX73362.1 Reactome: R-HSA-5545619 XAV939 inhibits tankyrase, stabilizing AXIN 1 KOX80121.1 MetaCyc: PWY-7661 Protein N-glycosylation (Haloferax volcanii) 1 KOX72243.1 KEGG: 00591+3.1.1.4 Linoleic acid metabolism 10 KOX69576.1;KOX78275.1;KOX75783.1;KOX77917.1;KOX70330.1;KOX72448.1;KOX79218.1;KOX78399.1;KOX69497.1;KOX78316.1 Reactome: R-HSA-4717374 Defective DPM1 causes DPM1-CDG (CDG-1e) 3 KOX73553.1;KOX72243.1;KOX78339.1 Reactome: R-HSA-179812 GRB2 events in EGFR signaling 1 KOX81204.1 MetaCyc: PWY-7218 Photosynthetic 3-hydroxybutanoate biosynthesis (engineered) 4 KOX74974.1;KOX81104.1;KOX74975.1;KOX71859.1 KEGG: 00510+2.4.1.117 N-Glycan biosynthesis 1 KOX70949.1 Reactome: R-HSA-8941284 RUNX2 regulates chondrocyte maturation 1 KOX79878.1 Reactome: R-HSA-1236974 ER-Phagosome pathway 43 KOX68313.1;KOX78786.1;KOX70383.1;KOX79363.1;KOX77271.1;KOX72982.1;KOX79230.1;KOX79601.1;KOX72105.1;KOX70419.1;KOX78273.1;KOX69414.1;KOX70579.1;KOX69333.1;KOX68748.1;KOX70760.1;KOX75968.1;KOX79626.1;KOX80008.1;KOX73060.1;KOX76416.1;KOX67229.1;KOX70009.1;KOX76009.1;KOX68314.1;KOX69069.1;KOX72411.1;KOX68497.1;KOX70598.1;KOX76879.1;KOX78266.1;KOX79430.1;KOX74011.1;KOX73209.1;KOX74910.1;KOX75984.1;KOX68636.1;KOX79433.1;KOX74924.1;KOX80582.1;KOX78268.1;KOX72468.1;KOX71606.1 Reactome: R-HSA-9013973 TICAM1-dependent activation of IRF3/IRF7 5 KOX79430.1;KOX79433.1;KOX70261.1;KOX72105.1;KOX67229.1 KEGG: 00760+6.3.4.21 Nicotinate and nicotinamide metabolism 1 KOX78224.1 MetaCyc: PWY-6799 Fatty acid biosynthesis initiation (plant mitochondria) 2 KOX73549.1;KOX69550.1 KEGG: 00270+1.1.1.95 Cysteine and methionine metabolism 1 KOX74576.1 Reactome: R-HSA-426048 Arachidonate production from DAG 1 KOX72979.1 MetaCyc: PWY-5739 GDP-D-perosamine biosynthesis 1 KOX69413.1 KEGG: 00030+2.7.1.11 Pentose phosphate pathway 1 KOX67867.1 Reactome: R-HSA-162594 Early Phase of HIV Life Cycle 1 KOX70179.1 MetaCyc: PWY-5905 Hypusine biosynthesis 1 KOX77509.1 Reactome: R-HSA-5668599 RHO GTPases Activate NADPH Oxidases 3 KOX68500.1;KOX75489.1;KOX76722.1 KEGG: 00510+2.4.1.131 N-Glycan biosynthesis 1 KOX72671.1 Reactome: R-HSA-1483213 Synthesis of PE 3 KOX70005.1;KOX67863.1;KOX67207.1 KEGG: 00240+3.6.1.9 Pyrimidine metabolism 2 KOX80826.1;KOX69334.1 KEGG: 00600+3.2.1.23 Sphingolipid metabolism 3 KOX75741.1;KOX77035.1;KOX80383.1 KEGG: 00030+5.3.1.6 Pentose phosphate pathway 1 KOX80223.1 Reactome: R-HSA-180336 SHC1 events in EGFR signaling 1 KOX81204.1 Reactome: R-HSA-8851907 MET activates PI3K/AKT signaling 1 KOX81204.1 KEGG: 00903+4.2.1.17 Limonene and pinene degradation 2 KOX75101.1;KOX76405.1 MetaCyc: PWY-7193 Pyrimidine ribonucleosides salvage I 2 KOX78077.1;KOX79373.1 Reactome: R-HSA-174403 Glutathione synthesis and recycling 7 KOX73052.1;KOX79873.1;KOX78147.1;KOX72668.1;KOX76540.1;KOX74355.1;KOX76321.1 KEGG: 00643+3.7.1.2 Styrene degradation 1 KOX69218.1 Reactome: R-HSA-2465910 MASTL Facilitates Mitotic Progression 1 KOX76312.1 KEGG: 00511+3.2.1.96 Other glycan degradation 1 KOX68878.1 MetaCyc: PWY-5690 TCA cycle II (plants and fungi) 12 KOX79891.1;KOX75374.1;KOX79460.1;KOX70050.1;KOX68928.1;KOX74316.1;KOX68680.1;KOX79892.1;KOX77859.1;KOX70049.1;KOX79955.1;KOX69541.1 KEGG: 00513+2.4.1.142 Various types of N-glycan biosynthesis 1 KOX80760.1 KEGG: 00790+1.14.16.2 Folate biosynthesis 1 KOX71846.1 Reactome: R-HSA-1368082 RORA activates gene expression 5 KOX69665.1;KOX76309.1;KOX74904.1;KOX68963.1;KOX78052.1 KEGG: 00564+2.7.1.107 Glycerophospholipid metabolism 4 KOX73249.1;KOX76676.1;KOX68067.1;KOX79421.1 Reactome: R-HSA-9630221 Defective NTHL1 substrate processing 1 KOX77492.1 Reactome: R-HSA-9022692 Regulation of MECP2 expression and activity 11 KOX70201.1;KOX74484.1;KOX71059.1;KOX71680.1;KOX78838.1;KOX74580.1;KOX68226.1;KOX79039.1;KOX67889.1;KOX68332.1;KOX76868.1 Reactome: R-HSA-216083 Integrin cell surface interactions 9 KOX72886.1;KOX67518.1;KOX74187.1;KOX75720.1;KOX70849.1;KOX70613.1;KOX68994.1;KOX74851.1;KOX75715.1 MetaCyc: PWY-7821 Tunicamycin biosynthesis 4 KOX80826.1;KOX69334.1;KOX75971.1;KOX75972.1 Reactome: R-HSA-180534 Vpu mediated degradation of CD4 40 KOX69414.1;KOX78273.1;KOX69333.1;KOX68748.1;KOX75968.1;KOX70760.1;KOX80008.1;KOX79626.1;KOX70383.1;KOX68313.1;KOX78786.1;KOX72982.1;KOX77271.1;KOX79363.1;KOX79230.1;KOX72105.1;KOX70419.1;KOX79601.1;KOX73209.1;KOX74011.1;KOX69688.1;KOX79433.1;KOX74924.1;KOX74910.1;KOX75984.1;KOX80582.1;KOX71606.1;KOX78268.1;KOX72468.1;KOX73060.1;KOX67229.1;KOX76416.1;KOX70009.1;KOX76009.1;KOX70598.1;KOX72411.1;KOX68314.1;KOX76879.1;KOX78266.1;KOX79430.1 MetaCyc: PWY-6517 N-acetylglucosamine degradation II 1 KOX72719.1 Reactome: R-HSA-445144 Signal transduction by L1 2 KOX68500.1;KOX79369.1 KEGG: 00053+3.1.1.17 Ascorbate and aldarate metabolism 1 KOX69067.1 KEGG: 00250+2.6.1.16 Alanine, aspartate and glutamate metabolism 1 KOX68219.1 Reactome: R-HSA-901032 ER Quality Control Compartment (ERQC) 6 KOX67229.1;KOX72105.1;KOX70394.1;KOX79430.1;KOX79433.1;KOX67853.1 Reactome: R-HSA-5579026 Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) 3 KOX77746.1;KOX74033.1;KOX80011.1 Reactome: R-HSA-975163 IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 5 KOX79433.1;KOX79430.1;KOX72105.1;KOX75998.1;KOX67229.1 MetaCyc: PWY-6536 4-aminobutanoate degradation III 1 KOX75380.1 MetaCyc: PWY-7587 Oleate biosynthesis III (cyanobacteria) 6 KOX67923.1;KOX80280.1;KOX79114.1;KOX77858.1;KOX75990.1;KOX76514.1 KEGG: 00860+6.1.1.17 Porphyrin and chlorophyll metabolism 2 KOX76511.1;KOX68068.1 KEGG: 00510+2.4.1.83 N-Glycan biosynthesis 1 KOX72243.1 Reactome: R-HSA-8849175 Threonine catabolism 3 KOX77844.1;KOX71147.1;KOX68041.1 KEGG: 04070+3.1.3.25 Phosphatidylinositol signaling system 3 KOX75546.1;KOX75545.1;KOX71857.1 Reactome: R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models 3 KOX73517.1;KOX79735.1;KOX67775.1 Reactome: R-HSA-381183 ATF6 (ATF6-alpha) activates chaperone genes 3 KOX73868.1;KOX79365.1;KOX77410.1 MetaCyc: PWY-7709 (3R)-linalool biosynthesis 1 KOX72808.1 Reactome: R-HSA-1250347 SHC1 events in ERBB4 signaling 1 KOX81204.1 Reactome: R-HSA-186763 Downstream signal transduction 4 KOX69748.1;KOX81204.1;KOX81245.1;KOX71656.1 KEGG: 00051+3.1.3.11 Fructose and mannose metabolism 1 KOX68814.1 MetaCyc: PWY-6370 Ascorbate recycling (cytosolic) 2 KOX71878.1;KOX69433.1 MetaCyc: PWY-7226 Guanosine deoxyribonucleotides de novo biosynthesis I 5 KOX78412.1;KOX71458.1;KOX78158.1;KOX79885.1;KOX76865.1 Reactome: R-HSA-3000157 Laminin interactions 6 KOX75592.1;KOX75715.1;KOX71888.1;KOX75126.1;KOX78294.1;KOX75720.1 KEGG: 00513+2.4.1.131 Various types of N-glycan biosynthesis 1 KOX72671.1 Reactome: R-HSA-5578999 Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) 2 KOX76321.1;KOX78147.1 MetaCyc: PWY-5667 CDP-diacylglycerol biosynthesis I 11 KOX68030.1;KOX80280.1;KOX75461.1;KOX77858.1;KOX76514.1;KOX79114.1;KOX75465.1;KOX67923.1;KOX75460.1;KOX67877.1;KOX75990.1 Reactome: R-HSA-74751 Insulin receptor signalling cascade 1 KOX81204.1 Reactome: R-HSA-109704 PI3K Cascade 3 KOX76722.1;KOX73103.1;KOX81204.1 Reactome: R-HSA-202670 ERKs are inactivated 2 KOX76312.1;KOX68500.1 MetaCyc: PWY-6383 Mono-trans, poly-cis decaprenyl phosphate biosynthesis 2 KOX72808.1;KOX74855.1 Reactome: R-HSA-5654700 FRS-mediated FGFR2 signaling 2 KOX67928.1;KOX81204.1 KEGG: 00240+6.3.4.2 Pyrimidine metabolism 1 KOX75796.1 MetaCyc: PWY-7219 Adenosine ribonucleotides de novo biosynthesis 10 KOX78710.1;KOX78323.1;KOX76788.1;KOX71192.1;KOX77775.1;KOX73294.1;KOX71530.1;KOX81300.1;KOX80742.1;KOX79001.1 MetaCyc: PWY-6502 8-oxo-(d)GTP detoxification I 1 KOX77507.1 KEGG: 00860+4.4.1.17 Porphyrin and chlorophyll metabolism 1 KOX78948.1 MetaCyc: PWY-7426 Complex N-linked glycan biosynthesis (vertebrates) 3 KOX77791.1;KOX77864.1;KOX79732.1 Reactome: R-HSA-74217 Purine salvage 7 KOX70951.1;KOX74844.1;KOX79221.1;KOX78203.1;KOX74349.1;KOX76542.1;KOX71685.1 Reactome: R-HSA-5467337 APC truncation mutants have impaired AXIN binding 5 KOX75788.1;KOX71037.1;KOX69536.1;KOX73320.1;KOX76312.1 Reactome: R-HSA-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 4 KOX67229.1;KOX79430.1;KOX79433.1;KOX72105.1 MetaCyc: PWY-7117 C4 photosynthetic carbon assimilation cycle, PEPCK type 5 KOX68087.1;KOX68932.1;KOX71428.1;KOX79912.1;KOX80775.1 KEGG: 00510+2.4.1.68 N-Glycan biosynthesis 1 KOX77864.1 MetaCyc: PWY-6308 L-cysteine biosynthesis II (tRNA-dependent) 3 KOX69213.1;KOX73886.1;KOX74209.1 MetaCyc: PWY-6932 Selenate reduction 2 KOX68057.1;KOX74601.1 KEGG: 00620+3.1.2.6 Pyruvate metabolism 1 KOX77340.1 KEGG: 00380+1.13.11.11 Tryptophan metabolism 1 KOX70876.1 MetaCyc: PWY-6788 Cellulose degradation II (fungi) 1 KOX76353.1 Reactome: R-HSA-425397 Transport of vitamins, nucleosides, and related molecules 1 KOX80453.1 MetaCyc: PWY-7659 Viridicatumtoxin biosynthesis 1 KOX72808.1 MetaCyc: PWY-7524 Mevalonate pathway III (archaea) 2 KOX70405.1;KOX74855.1 Reactome: R-HSA-8964011 HDL clearance 1 KOX71101.1 KEGG: 00970+6.1.1.15 Aminoacyl-tRNA biosynthesis 2 KOX72739.1;KOX76511.1 Reactome: R-HSA-189451 Heme biosynthesis 9 KOX74171.1;KOX75988.1;KOX78502.1;KOX80939.1;KOX72295.1;KOX69203.1;KOX78820.1;KOX79366.1;KOX73781.1 Reactome: R-HSA-937041 IKK complex recruitment mediated by RIP1 5 KOX67229.1;KOX68495.1;KOX72105.1;KOX79433.1;KOX79430.1 Reactome: R-HSA-3359462 Defective AMN causes hereditary megaloblastic anemia 1 1 KOX71101.1 Reactome: R-HSA-446205 Synthesis of GDP-mannose 4 KOX72772.1;KOX80031.1;KOX70129.1;KOX74805.1 Reactome: R-HSA-5250958 Toxicity of botulinum toxin type B (BoNT/B) 1 KOX76332.1 MetaCyc: PWY-8072 Alanine racemization 1 KOX79794.1 MetaCyc: PWY-5686 UMP biosynthesis I 4 KOX71473.1;KOX80440.1;KOX72385.1;KOX80442.1 Reactome: R-HSA-6803205 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 3 KOX67356.1;KOX68050.1;KOX80158.1 Reactome: R-HSA-5601884 PIWI-interacting RNA (piRNA) biogenesis 11 KOX79649.1;KOX80333.1;KOX67200.1;KOX77626.1;KOX73439.1;KOX70044.1;KOX75315.1;KOX81203.1;KOX73198.1;KOX77062.1;KOX77063.1 KEGG: 00970+6.1.1.18 Aminoacyl-tRNA biosynthesis 1 KOX71972.1 MetaCyc: PWY-7571 Ferrichrome A biosynthesis 1 KOX70405.1 Reactome: R-HSA-8939902 Regulation of RUNX2 expression and activity 43 KOX78273.1;KOX69414.1;KOX68748.1;KOX69333.1;KOX70760.1;KOX75968.1;KOX79626.1;KOX80008.1;KOX78786.1;KOX68313.1;KOX70383.1;KOX79878.1;KOX77271.1;KOX79363.1;KOX72982.1;KOX79230.1;KOX79601.1;KOX70419.1;KOX72105.1;KOX74011.1;KOX73209.1;KOX75984.1;KOX74910.1;KOX77551.1;KOX79433.1;KOX74924.1;KOX69688.1;KOX80582.1;KOX72468.1;KOX78268.1;KOX71606.1;KOX73376.1;KOX67229.1;KOX76416.1;KOX73060.1;KOX76009.1;KOX70009.1;KOX68314.1;KOX72411.1;KOX70598.1;KOX79430.1;KOX76879.1;KOX78266.1 KEGG: 05165+2.7.11.1 Human papillomavirus infection 40 KOX79817.1;KOX69619.1;KOX71579.1;KOX68054.1;KOX70861.1;KOX72201.1;KOX74186.1;KOX77898.1;KOX79675.1;KOX78509.1;KOX74477.1;KOX68647.1;KOX76214.1;KOX81246.1;KOX78841.1;KOX77364.1;KOX72400.1;KOX73463.1;KOX69995.1;KOX79225.1;KOX76221.1;KOX70676.1;KOX79935.1;KOX68566.1;KOX79039.1;KOX77803.1;KOX70561.1;KOX68521.1;KOX74479.1;KOX79033.1;KOX77506.1;KOX73800.1;KOX68654.1;KOX68084.1;KOX79166.1;KOX73362.1;KOX71595.1;KOX79522.1;KOX78362.1;KOX73724.1 Reactome: R-HSA-1369062 ABC transporters in lipid homeostasis 17 KOX81386.1;KOX79142.1;KOX79247.1;KOX68603.1;KOX73112.1;KOX79246.1;KOX75571.1;KOX81387.1;KOX73111.1;KOX74021.1;KOX72124.1;KOX81383.1;KOX80294.1;KOX67202.1;KOX72127.1;KOX72029.1;KOX81384.1 KEGG: 00620+4.2.1.2 Pyruvate metabolism 1 KOX77859.1 Reactome: R-HSA-69052 Switching of origins to a post-replicative state 7 KOX76493.1;KOX69273.1;KOX68806.1;KOX72070.1;KOX70033.1;KOX70391.1;KOX74494.1 KEGG: 00680+4.2.1.11 Methane metabolism 2 KOX71859.1;KOX81104.1 MetaCyc: PWY-5871 Ubiquinol-9 biosynthesis (eukaryotic) 3 KOX72023.1;KOX77776.1;KOX70323.1 Reactome: R-HSA-163282 Mitochondrial transcription initiation 2 KOX68053.1;KOX70356.1 KEGG: 00630+6.3.1.2 Glyoxylate and dicarboxylate metabolism 1 KOX75490.1 KEGG: 00564+2.3.1.15 Glycerophospholipid metabolism 2 KOX76514.1;KOX80280.1 KEGG: 00230+6.3.2.6 Purine metabolism 1 KOX67690.1 KEGG: 00030+2.2.1.2 Pentose phosphate pathway 1 KOX67931.1 KEGG: 00562+2.7.1.134+2.7.1.159 Inositol phosphate metabolism 1 KOX80873.1 Reactome: R-HSA-399719 Trafficking of AMPA receptors 3 KOX68226.1;KOX70039.1;KOX78706.1 Reactome: R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane 102 KOX69807.1;KOX79914.1;KOX74170.1;KOX71198.1;KOX81388.1;KOX74407.1;KOX73982.1;KOX68044.1;KOX72105.1;KOX74103.1;KOX77134.1;KOX67280.1;KOX72644.1;KOX74668.1;KOX75797.1;KOX74357.1;KOX75024.1;KOX76065.1;KOX75483.1;KOX71077.1;KOX72185.1;KOX78350.1;KOX72660.1;KOX81215.1;KOX75947.1;KOX71988.1;KOX71472.1;KOX68431.1;KOX77911.1;KOX74637.1;KOX76114.1;KOX67361.1;KOX79160.1;KOX67259.1;KOX73344.1;KOX77016.1;KOX80864.1;KOX75227.1;KOX71651.1;KOX76900.1;KOX78568.1;KOX79433.1;KOX68636.1;KOX79738.1;KOX70646.1;KOX70024.1;KOX77868.1;KOX67237.1;KOX80722.1;KOX72904.1;KOX75945.1;KOX72125.1;KOX77642.1;KOX75432.1;KOX73889.1;KOX69002.1;KOX67227.1;KOX69003.1;KOX78826.1;KOX73120.1;KOX70579.1;KOX68744.1;KOX68107.1;KOX70874.1;KOX75358.1;KOX78670.1;KOX68042.1;KOX73099.1;KOX73450.1;KOX78289.1;KOX74804.1;KOX74243.1;KOX70176.1;KOX77188.1;KOX74886.1;KOX70411.1;KOX75143.1;KOX67229.1;KOX71403.1;KOX67699.1;KOX67698.1;KOX70147.1;KOX79430.1;KOX67935.1;KOX81212.1;KOX69069.1;KOX72330.1;KOX79611.1;KOX67807.1;KOX75958.1;KOX77641.1;KOX73308.1;KOX70543.1;KOX72074.1;KOX75568.1;KOX67929.1;KOX78800.1;KOX70724.1;KOX67795.1;KOX71471.1;KOX67830.1;KOX71394.1 Reactome: R-HSA-111448 Activation of NOXA and translocation to mitochondria 1 KOX80899.1 Reactome: R-HSA-4720489 Defective ALG12 causes ALG12-CDG (CDG-1g) 1 KOX77289.1 Reactome: R-HSA-5083633 Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 3 KOX71057.1;KOX80772.1;KOX70674.1 Reactome: R-HSA-5099900 WNT5A-dependent internalization of FZD4 5 KOX68797.1;KOX76387.1;KOX76831.1;KOX69299.1;KOX79275.1 Reactome: R-HSA-9017802 Noncanonical activation of NOTCH3 4 KOX69998.1;KOX70021.1;KOX68228.1;KOX77051.1 KEGG: 00380+1.8.1.4 Tryptophan metabolism 1 KOX75086.1 MetaCyc: PWY-6855 Chitin degradation I (archaea) 8 KOX75966.1;KOX79324.1;KOX77106.1;KOX67942.1;KOX79466.1;KOX72270.1;KOX79627.1;KOX81368.1 Reactome: R-HSA-193692 Regulated proteolysis of p75NTR 5 KOX68228.1;KOX70021.1;KOX69998.1;KOX77051.1;KOX67619.1 MetaCyc: PWY-7817 Type I lipoteichoic acid biosynthesis (S. aureus) 9 KOX74437.1;KOX79421.1;KOX67374.1;KOX67809.1;KOX68030.1;KOX67877.1;KOX73249.1;KOX76676.1;KOX68067.1 Reactome: R-HSA-111471 Apoptotic factor-mediated response 1 KOX70403.1 Reactome: R-HSA-1296072 Voltage gated Potassium channels 13 KOX72456.1;KOX72561.1;KOX78401.1;KOX72560.1;KOX70822.1;KOX70820.1;KOX72453.1;KOX79650.1;KOX79653.1;KOX72263.1;KOX70819.1;KOX76188.1;KOX68038.1 Reactome: R-HSA-5173105 O-linked glycosylation 4 KOX71057.1;KOX80772.1;KOX69179.1;KOX70674.1 Reactome: R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 20 KOX75630.1;KOX79436.1;KOX80793.1;KOX72429.1;KOX75539.1;KOX72473.1;KOX69061.1;KOX73226.1;KOX80341.1;KOX68732.1;KOX78183.1;KOX73131.1;KOX77058.1;KOX77505.1;KOX73664.1;KOX79242.1;KOX75811.1;KOX68874.1;KOX81376.1;KOX75540.1 Reactome: R-HSA-196108 Pregnenolone biosynthesis 3 KOX77746.1;KOX74033.1;KOX80011.1 MetaCyc: PWY-5723 Rubisco shunt 6 KOX67931.1;KOX80223.1;KOX74975.1;KOX71859.1;KOX74974.1;KOX81104.1 MetaCyc: PWY-5384 Sucrose degradation IV (sucrose phosphorylase) 1 KOX67919.1 Reactome: R-HSA-5358747 S33 mutants of beta-catenin aren't phosphorylated 5 KOX73320.1;KOX76312.1;KOX75788.1;KOX71037.1;KOX69536.1 MetaCyc: PWY-7573 GDP-mycosamine biosynthesis 1 KOX69413.1 MetaCyc: PWY-6342 Noradrenaline and adrenaline degradation 1 KOX67600.1 KEGG: 00770+2.7.1.24 Pantothenate and CoA biosynthesis 2 KOX69837.1;KOX70265.1 Reactome: R-HSA-2299718 Condensation of Prophase Chromosomes 8 KOX70292.1;KOX77330.1;KOX74217.1;KOX68901.1;KOX74645.1;KOX74623.1;KOX74214.1;KOX76078.1 KEGG: 00600+3.5.1.23 Sphingolipid metabolism 2 KOX71112.1;KOX71109.1 MetaCyc: PWY-7197 Pyrimidine deoxyribonucleotide phosphorylation 5 KOX78158.1;KOX76865.1;KOX78412.1;KOX71458.1;KOX79122.1 MetaCyc: PWY-7999 Vitamin K-epoxide cycle 2 KOX69948.1;KOX79863.1 Reactome: R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 20 KOX80793.1;KOX79436.1;KOX75630.1;KOX75539.1;KOX72429.1;KOX69061.1;KOX72473.1;KOX78183.1;KOX68732.1;KOX80341.1;KOX73226.1;KOX77058.1;KOX73131.1;KOX77505.1;KOX73664.1;KOX81376.1;KOX68874.1;KOX75811.1;KOX79242.1;KOX75540.1 Reactome: R-HSA-947581 Molybdenum cofactor biosynthesis 6 KOX76132.1;KOX71043.1;KOX81080.1;KOX71042.1;KOX69728.1;KOX69261.1 Reactome: R-HSA-8875656 MET receptor recycling 3 KOX81204.1;KOX79055.1;KOX81245.1 KEGG: 00270+1.13.11.54 Cysteine and methionine metabolism 1 KOX79884.1 KEGG: 00520+3.5.1.25 Amino sugar and nucleotide sugar metabolism 1 KOX77757.1 MetaCyc: PWY-6963 Ammonia assimilation cycle I 1 KOX75490.1 KEGG: 00052+2.7.1.6 Galactose metabolism 2 KOX67564.1;KOX68891.1 Reactome: R-HSA-1855167 Synthesis of pyrophosphates in the cytosol 5 KOX81239.1;KOX80873.1;KOX81095.1;KOX81238.1;KOX81098.1 Reactome: R-HSA-9613354 Lipophagy 2 KOX69814.1;KOX75316.1 KEGG: 00670+2.1.1.45 One carbon pool by folate 1 KOX71982.1 MetaCyc: PWY-5466 Matairesinol biosynthesis 2 KOX77231.1;KOX69438.1 Reactome: R-HSA-349425 Autodegradation of the E3 ubiquitin ligase COP1 41 KOX75968.1;KOX70760.1;KOX80008.1;KOX79626.1;KOX69414.1;KOX78273.1;KOX68748.1;KOX69333.1;KOX79230.1;KOX70419.1;KOX72105.1;KOX79601.1;KOX70383.1;KOX78786.1;KOX68313.1;KOX72982.1;KOX77271.1;KOX79363.1;KOX80582.1;KOX71606.1;KOX72468.1;KOX78268.1;KOX73209.1;KOX74011.1;KOX74924.1;KOX79433.1;KOX75984.1;KOX74910.1;KOX70598.1;KOX72753.1;KOX68314.1;KOX72411.1;KOX79430.1;KOX68054.1;KOX76879.1;KOX78266.1;KOX67229.1;KOX76416.1;KOX73060.1;KOX76009.1;KOX70009.1 MetaCyc: PWY-7805 (aminomethyl)phosphonate degradation 3 KOX74349.1;KOX78499.1;KOX68266.1 Reactome: R-HSA-381070 IRE1alpha activates chaperones 1 KOX79365.1 Reactome: R-HSA-8851708 Signaling by FGFR2 IIIa TM 12 KOX77626.1;KOX74909.1;KOX70044.1;KOX77418.1;KOX79649.1;KOX67200.1;KOX77062.1;KOX77063.1;KOX74908.1;KOX81203.1;KOX73198.1;KOX74806.1 Reactome: R-HSA-139915 Activation of PUMA and translocation to mitochondria 2 KOX80899.1;KOX80158.1 Reactome: R-HSA-9031525 NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake 1 KOX72138.1 Reactome: R-HSA-1221632 Meiotic synapsis 8 KOX77330.1;KOX77869.1;KOX79522.1;KOX74217.1;KOX75315.1;KOX74214.1;KOX71763.1;KOX74954.1 Reactome: R-HSA-73621 Pyrimidine catabolism 5 KOX79553.1;KOX77619.1;KOX79554.1;KOX67708.1;KOX77918.1 Reactome: R-HSA-2468052 Establishment of Sister Chromatid Cohesion 5 KOX68193.1;KOX80378.1;KOX77869.1;KOX74954.1;KOX70177.1 MetaCyc: PWY-7214 Baicalein degradation (hydrogen peroxide detoxification) 2 KOX69438.1;KOX77231.1 Reactome: R-HSA-5339700 TCF7L2 mutants don't bind CTBP 1 KOX78528.1 Reactome: R-HSA-4090294 SUMOylation of intracellular receptors 3 KOX69371.1;KOX69256.1;KOX75920.1 KEGG: 00270+6.3.2.2 Cysteine and methionine metabolism 1 KOX78147.1 MetaCyc: PWY-5857 Ubiquinol-10 biosynthesis (prokaryotic) 3 KOX70323.1;KOX72023.1;KOX77776.1 Reactome: R-HSA-9033807 ABO blood group biosynthesis 1 KOX67571.1 Reactome: R-HSA-5685938 HDR through Single Strand Annealing (SSA) 26 KOX72024.1;KOX78861.1;KOX73599.1;KOX73670.1;KOX69173.1;KOX80895.1;KOX74923.1;KOX74812.1;KOX79548.1;KOX80977.1;KOX71452.1;KOX68669.1;KOX79522.1;KOX79196.1;KOX68243.1;KOX70402.1;KOX71424.1;KOX68054.1;KOX71786.1;KOX71763.1;KOX80991.1;KOX79987.1;KOX75935.1;KOX72417.1;KOX72862.1;KOX73285.1 MetaCyc: PWY-7883 Anhydromuropeptides recycling II 4 KOX74631.1;KOX73530.1;KOX74285.1;KOX74395.1 MetaCyc: PWY-7838 Globo-series glycosphingolipids biosynthesis 1 KOX74918.1 Reactome: R-HSA-3928662 EPHB-mediated forward signaling 8 KOX69748.1;KOX78779.1;KOX76191.1;KOX77415.1;KOX72186.1;KOX68537.1;KOX68066.1;KOX74872.1 KEGG: 00590+5.3.99.3 Arachidonic acid metabolism 1 KOX68049.1 MetaCyc: PWY-8047 Bryostatin biosynthesis 2 KOX69550.1;KOX73549.1 Reactome: R-HSA-390648 Muscarinic acetylcholine receptors 1 KOX67346.1 KEGG: 00670+2.1.2.9 One carbon pool by folate 3 KOX79954.1;KOX75639.1;KOX71788.1 Reactome: R-HSA-163680 AMPK inhibits chREBP transcriptional activation activity 2 KOX74479.1;KOX69814.1 KEGG: 00860+2.5.1.61 Porphyrin and chlorophyll metabolism 1 KOX73781.1 KEGG: 04150+2.7.1.153 mTOR signaling pathway 1 KOX79243.1 MetaCyc: PWY-2161 Folate polyglutamylation 5 KOX77269.1;KOX69033.1;KOX69388.1;KOX69389.1;KOX79374.1 Reactome: R-HSA-1614603 Cysteine formation from homocysteine 2 KOX69981.1;KOX79432.1 Reactome: R-HSA-8951911 RUNX3 regulates RUNX1-mediated transcription 1 KOX79878.1 MetaCyc: PWY-6012 Acyl carrier protein metabolism 1 KOX75794.1 MetaCyc: PWY-2541 Phytosterol biosynthesis (plants) 1 KOX78838.1 Reactome: R-HSA-983231 Factors involved in megakaryocyte development and platelet production 22 KOX73891.1;KOX81018.1;KOX75989.1;KOX68945.1;KOX80895.1;KOX80873.1;KOX67995.1;KOX69052.1;KOX71680.1;KOX69723.1;KOX78779.1;KOX67846.1;KOX73191.1;KOX74139.1;KOX76191.1;KOX75088.1;KOX78941.1;KOX71184.1;KOX74882.1;KOX74387.1;KOX70345.1;KOX80154.1 KEGG: 00627+3.6.1.7 Aminobenzoate degradation 1 KOX78240.1 Reactome: R-HSA-1433559 Regulation of KIT signaling 2 KOX77407.1;KOX81204.1 KEGG: 00270+4.1.1.50 Cysteine and methionine metabolism 2 KOX68062.1;KOX68063.1 KEGG: 04070+3.1.3.36 Phosphatidylinositol signaling system 2 KOX75106.1;KOX74178.1 Reactome: R-HSA-390918 Peroxisomal lipid metabolism 1 KOX69329.1 Reactome: R-HSA-167160 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 21 KOX77062.1;KOX81403.1;KOX69897.1;KOX74806.1;KOX73785.1;KOX79649.1;KOX72538.1;KOX69719.1;KOX74919.1;KOX77063.1;KOX81203.1;KOX73198.1;KOX76411.1;KOX74030.1;KOX70044.1;KOX69540.1;KOX78553.1;KOX77626.1;KOX77418.1;KOX79850.1;KOX67200.1 Reactome: R-HSA-4551295 Defective ALG11 causes ALG11-CDG (CDG-1p) 1 KOX72671.1 MetaCyc: PWY-7165 L-ascorbate biosynthesis VI (engineered pathway) 1 KOX69067.1 KEGG: 00514+2.4.1.122 Other types of O-glycan biosynthesis 1 KOX71619.1 MetaCyc: PWY-7726 (4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase) 6 KOX71616.1;KOX76405.1;KOX78236.1;KOX75101.1;KOX73119.1;KOX79701.1 Reactome: R-HSA-9010642 ROBO receptors bind AKAP5 1 KOX74139.1 Reactome: R-HSA-1855191 Synthesis of IPs in the nucleus 2 KOX81095.1;KOX81098.1 MetaCyc: PWY-6366 D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis 1 KOX80873.1 Reactome: R-HSA-69481 G2/M Checkpoints 39 KOX75984.1;KOX74910.1;KOX74924.1;KOX79433.1;KOX74011.1;KOX73209.1;KOX72468.1;KOX78268.1;KOX71606.1;KOX80582.1;KOX76009.1;KOX70009.1;KOX67229.1;KOX76416.1;KOX73060.1;KOX79430.1;KOX78266.1;KOX76879.1;KOX68314.1;KOX72411.1;KOX70598.1;KOX68748.1;KOX69333.1;KOX78273.1;KOX69414.1;KOX79626.1;KOX80008.1;KOX70760.1;KOX75968.1;KOX79363.1;KOX77271.1;KOX72982.1;KOX78786.1;KOX68313.1;KOX70383.1;KOX79601.1;KOX70419.1;KOX72105.1;KOX79230.1 Reactome: R-HSA-9037629 Lewis blood group biosynthesis 5 KOX74983.1;KOX68778.1;KOX77553.1;KOX68776.1;KOX68777.1 MetaCyc: PWY-7442 Drosopterin and aurodrosopterin biosynthesis 2 KOX73844.1;KOX73788.1 Reactome: R-HSA-168325 Viral Messenger RNA Synthesis 30 KOX80341.1;KOX73226.1;KOX68732.1;KOX70044.1;KOX78183.1;KOX77626.1;KOX77418.1;KOX72473.1;KOX67200.1;KOX69061.1;KOX72429.1;KOX75539.1;KOX77063.1;KOX75630.1;KOX81203.1;KOX80793.1;KOX73198.1;KOX79436.1;KOX75540.1;KOX79649.1;KOX79242.1;KOX81376.1;KOX68874.1;KOX75811.1;KOX77062.1;KOX77505.1;KOX73664.1;KOX73131.1;KOX77058.1;KOX74806.1 Reactome: R-HSA-9022702 MECP2 regulates transcription of neuronal ligands 1 KOX71680.1 Reactome: R-HSA-5334118 DNA methylation 6 KOX77330.1;KOX74214.1;KOX74217.1;KOX77963.1;KOX74441.1;KOX74005.1 Reactome: R-HSA-3065676 SUMO is conjugated to E1 (UBA2:SAE1) 1 KOX78175.1 KEGG: 00310+1.2.4.2 Lysine degradation 3 KOX67894.1;KOX76981.1;KOX78238.1 MetaCyc: PWY-6433 Hydroxylated fatty acid biosynthesis (plants) 21 KOX80068.1;KOX78660.1;KOX78651.1;KOX78659.1;KOX75202.1;KOX74597.1;KOX68278.1;KOX78653.1;KOX68279.1;KOX73201.1;KOX78713.1;KOX78236.1;KOX67486.1;KOX79701.1;KOX78662.1;KOX78657.1;KOX78650.1;KOX78654.1;KOX77795.1;KOX67350.1;KOX68696.1 MetaCyc: PWY-6803 Phosphatidylcholine acyl editing 10 KOX77917.1;KOX72448.1;KOX70330.1;KOX78275.1;KOX69576.1;KOX75783.1;KOX78316.1;KOX79218.1;KOX69497.1;KOX78399.1 Reactome: R-HSA-416482 G alpha (12/13) signalling events 18 KOX80890.1;KOX79467.1;KOX71583.1;KOX78997.1;KOX78917.1;KOX69081.1;KOX81333.1;KOX74663.1;KOX73980.1;KOX74133.1;KOX78343.1;KOX69925.1;KOX76508.1;KOX68654.1;KOX79097.1;KOX71191.1;KOX71441.1;KOX79656.1 KEGG: 00220+2.6.1.1 Arginine biosynthesis 2 KOX79912.1;KOX71428.1 MetaCyc: PWY-6920 6-gingerol analog biosynthesis (engineered) 2 KOX71616.1;KOX73119.1 Reactome: R-HSA-156581 Methylation 3 KOX67731.1;KOX78457.1;KOX77579.1 KEGG: 00970+6.1.1.11 Aminoacyl-tRNA biosynthesis 3 KOX75283.1;KOX76367.1;KOX69204.1 Reactome: R-HSA-1236978 Cross-presentation of soluble exogenous antigens (endosomes) 35 KOX72982.1;KOX77271.1;KOX79363.1;KOX70383.1;KOX68313.1;KOX78786.1;KOX70419.1;KOX79601.1;KOX79230.1;KOX69333.1;KOX68748.1;KOX69414.1;KOX78273.1;KOX80008.1;KOX79626.1;KOX75968.1;KOX70760.1;KOX70009.1;KOX76009.1;KOX73060.1;KOX76416.1;KOX78266.1;KOX76879.1;KOX70598.1;KOX68314.1;KOX72411.1;KOX74924.1;KOX74910.1;KOX75984.1;KOX73209.1;KOX74011.1;KOX71606.1;KOX78268.1;KOX72468.1;KOX80582.1 Reactome: R-HSA-159227 Transport of the SLBP independent Mature mRNA 22 KOX80793.1;KOX79436.1;KOX75630.1;KOX75539.1;KOX72429.1;KOX69061.1;KOX72473.1;KOX78183.1;KOX68732.1;KOX73226.1;KOX80341.1;KOX77058.1;KOX73131.1;KOX74908.1;KOX77505.1;KOX73664.1;KOX81376.1;KOX68874.1;KOX75811.1;KOX79242.1;KOX74909.1;KOX75540.1 MetaCyc: PWY-6605 Adenine and adenosine salvage II 1 KOX74349.1 MetaCyc: PWY-7180 2-deoxy-alpha-D-ribose 1-phosphate degradation 1 KOX77910.1 Reactome: R-HSA-354192 Integrin signaling 1 KOX78362.1 Reactome: R-HSA-9665251 Resistance of ERBB2 KD mutants to lapatinib 1 KOX73791.1 MetaCyc: PWY-7900 Glycogen biosynthesis III (from alpha-maltose 1-phosphate) 2 KOX70625.1;KOX68382.1 MetaCyc: PWY-5269 Cardiolipin biosynthesis II 2 KOX67809.1;KOX74437.1 KEGG: 00500+2.7.1.1 Starch and sucrose metabolism 2 KOX72065.1;KOX80688.1 MetaCyc: PWY-7437 Protein O-[N-acetyl]-glucosylation 2 KOX78555.1;KOX78410.1 Reactome: R-HSA-2206291 MPS IIIC - Sanfilippo syndrome C 1 KOX80589.1 Reactome: R-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF) 4 KOX69063.1;KOX69066.1;KOX70797.1;KOX70893.1 Reactome: R-HSA-5663213 RHO GTPases Activate WASPs and WAVEs 17 KOX77415.1;KOX80062.1;KOX76191.1;KOX78337.1;KOX69804.1;KOX81204.1;KOX74872.1;KOX68066.1;KOX78334.1;KOX72186.1;KOX80895.1;KOX78779.1;KOX74888.1;KOX68500.1;KOX76112.1;KOX72811.1;KOX76825.1 KEGG: 00620+6.4.1.2 Pyruvate metabolism 1 KOX70011.1 KEGG: 00534+2.4.1.224+2.4.1.225 Glycosaminoglycan biosynthesis - heparan sulfate / heparin 2 KOX77892.1;KOX74836.1 Reactome: R-HSA-2871796 FCERI mediated MAPK activation 6 KOX71582.1;KOX73517.1;KOX68500.1;KOX80039.1;KOX79097.1;KOX81204.1 MetaCyc: PWY-5367 Petroselinate biosynthesis 2 KOX73549.1;KOX69550.1 KEGG: 00240+3.6.1.17 Pyrimidine metabolism 1 KOX76220.1 Reactome: R-HSA-379716 Cytosolic tRNA aminoacylation 15 KOX72206.1;KOX76511.1;KOX79534.1;KOX67618.1;KOX75283.1;KOX71397.1;KOX71409.1;KOX75798.1;KOX72994.1;KOX69801.1;KOX71748.1;KOX72205.1;KOX79545.1;KOX78851.1;KOX71972.1 Reactome: R-HSA-9013508 NOTCH3 Intracellular Domain Regulates Transcription 4 KOX69604.1;KOX69665.1;KOX67158.1;KOX71242.1 MetaCyc: PWY-5913 Partial TCA cycle (obligate autotrophs) 13 KOX75374.1;KOX79460.1;KOX79891.1;KOX68928.1;KOX79912.1;KOX74316.1;KOX79046.1;KOX70050.1;KOX71428.1;KOX77859.1;KOX79892.1;KOX69541.1;KOX70049.1 Reactome: R-HSA-1660662 Glycosphingolipid metabolism 15 KOX67419.1;KOX71109.1;KOX77823.1;KOX74918.1;KOX69240.1;KOX74631.1;KOX73530.1;KOX68502.1;KOX74285.1;KOX76826.1;KOX78939.1;KOX76185.1;KOX77824.1;KOX76881.1;KOX71112.1 KEGG: 00510+2.4.1.142 N-Glycan biosynthesis 1 KOX80760.1 MetaCyc: PWY-5022 4-aminobutanoate degradation V 1 KOX75380.1 Reactome: R-HSA-8964572 Lipid particle organization 1 KOX68027.1 KEGG: 00190+1.3.5.1 Oxidative phosphorylation 2 KOX79955.1;KOX68680.1 KEGG: 00640+1.2.1.27 Propanoate metabolism 1 KOX81134.1 Reactome: R-HSA-9615710 Late endosomal microautophagy 10 KOX74322.1;KOX69076.1;KOX72105.1;KOX80074.1;KOX79430.1;KOX78305.1;KOX71636.1;KOX72168.1;KOX67229.1;KOX79433.1 KEGG: 00190+7.1.2.2 Oxidative phosphorylation 4 KOX73541.1;KOX72760.1;KOX78342.1;KOX79538.1 KEGG: 00643+1.13.11.5 Styrene degradation 2 KOX80034.1;KOX80035.1 MetaCyc: PWY-5839 Menaquinol-7 biosynthesis 1 KOX75964.1 Reactome: R-HSA-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 1 KOX68049.1 Reactome: R-HSA-5668541 TNFR2 non-canonical NF-kB pathway 39 KOX73209.1;KOX74011.1;KOX74924.1;KOX79433.1;KOX75984.1;KOX74910.1;KOX80582.1;KOX71606.1;KOX72468.1;KOX78268.1;KOX76416.1;KOX67229.1;KOX73060.1;KOX76009.1;KOX70009.1;KOX70598.1;KOX72411.1;KOX68314.1;KOX79430.1;KOX78266.1;KOX76879.1;KOX69414.1;KOX78273.1;KOX68748.1;KOX69333.1;KOX75968.1;KOX70760.1;KOX80008.1;KOX79626.1;KOX70383.1;KOX78786.1;KOX68313.1;KOX72982.1;KOX79363.1;KOX77271.1;KOX79230.1;KOX70419.1;KOX72105.1;KOX79601.1 Reactome: R-HSA-73933 Resolution of Abasic Sites (AP sites) 1 KOX77974.1 KEGG: 00790+6.3.2.17 Folate biosynthesis 1 KOX79374.1 KEGG: 00270+3.1.3.77 Cysteine and methionine metabolism 1 KOX71289.1 Reactome: R-HSA-6804758 Regulation of TP53 Activity through Acetylation 4 KOX77394.1;KOX72400.1;KOX73324.1;KOX74602.1 MetaCyc: PWY-7922 Protein O-mannosylation II (mammals, core M1 and core M2) 6 KOX70674.1;KOX72243.1;KOX81252.1;KOX77837.1;KOX71057.1;KOX72250.1 Reactome: R-HSA-4608870 Asymmetric localization of PCP proteins 40 KOX72105.1;KOX70419.1;KOX79601.1;KOX79230.1;KOX72982.1;KOX79363.1;KOX77271.1;KOX70383.1;KOX68313.1;KOX78786.1;KOX80008.1;KOX79626.1;KOX75968.1;KOX70760.1;KOX69333.1;KOX68748.1;KOX69414.1;KOX78273.1;KOX76879.1;KOX78266.1;KOX79430.1;KOX70598.1;KOX68314.1;KOX72411.1;KOX70009.1;KOX80053.1;KOX76009.1;KOX73060.1;KOX76416.1;KOX67229.1;KOX71606.1;KOX78268.1;KOX72468.1;KOX80582.1;KOX74924.1;KOX79433.1;KOX74910.1;KOX75984.1;KOX73209.1;KOX74011.1 Reactome: R-HSA-8951936 RUNX3 regulates p14-ARF 1 KOX79878.1 MetaCyc: PWY-6728 Methylaspartate cycle 13 KOX79460.1;KOX75374.1;KOX79891.1;KOX68928.1;KOX74316.1;KOX79046.1;KOX70050.1;KOX77859.1;KOX68680.1;KOX79892.1;KOX70049.1;KOX79955.1;KOX69541.1 KEGG: 00270+2.5.1.6 Cysteine and methionine metabolism 1 KOX77579.1 MetaCyc: PWY-5154 L-arginine biosynthesis III (via N-acetyl-L-citrulline) 3 KOX81392.1;KOX69117.1;KOX80440.1 MetaCyc: PWY-6824 Justicidin B biosynthesis 2 KOX77231.1;KOX69438.1 MetaCyc: PWY-6361 1D-myo-inositol hexakisphosphate biosynthesis I (from Ins(1,4,5)P3) 2 KOX81095.1;KOX81098.1 MetaCyc: PWY-6733 Sporopollenin precursors biosynthesis 25 KOX67575.1;KOX70026.1;KOX67276.1;KOX72974.1;KOX76757.1;KOX70665.1;KOX67582.1;KOX77819.1;KOX76200.1;KOX80980.1;KOX76705.1;KOX74747.1;KOX68371.1;KOX68693.1;KOX72289.1;KOX70025.1;KOX67597.1;KOX75132.1;KOX74314.1;KOX67581.1;KOX67284.1;KOX67261.1;KOX68698.1;KOX68699.1;KOX67285.1 MetaCyc: PWY-8060 2-deoxy-D-ribose degradation I 1 KOX77910.1 KEGG: 00450+6.1.1.10 Selenocompound metabolism 1 KOX69873.1 Reactome: R-HSA-9613829 Chaperone Mediated Autophagy 5 KOX72105.1;KOX79433.1;KOX79430.1;KOX67229.1;KOX74322.1 MetaCyc: PWY-7343 UDP-alpha-D-glucose biosynthesis I 1 KOX67374.1 Reactome: R-HSA-193681 Ceramide signalling 1 KOX76826.1 Reactome: R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex 50 KOX71988.1;KOX75064.1;KOX68431.1;KOX74637.1;KOX77911.1;KOX75797.1;KOX68107.1;KOX70174.1;KOX75024.1;KOX75483.1;KOX76065.1;KOX71077.1;KOX70874.1;KOX75967.1;KOX77134.1;KOX78826.1;KOX74668.1;KOX67969.1;KOX70175.1;KOX72470.1;KOX72644.1;KOX77634.1;KOX70202.1;KOX79914.1;KOX73889.1;KOX79833.1;KOX67237.1;KOX78800.1;KOX72904.1;KOX67795.1;KOX72125.1;KOX71394.1;KOX69593.1;KOX80758.1;KOX67807.1;KOX75958.1;KOX76900.1;KOX79433.1;KOX72074.1;KOX70024.1;KOX67810.1;KOX69171.1;KOX77016.1;KOX80864.1;KOX81212.1;KOX79430.1;KOX75227.1;KOX80902.1;KOX70176.1;KOX67229.1 Reactome: R-HSA-6804760 Regulation of TP53 Activity through Methylation 8 KOX76845.1;KOX67229.1;KOX79433.1;KOX69369.1;KOX68054.1;KOX79430.1;KOX68901.1;KOX72105.1 KEGG: 00650+2.6.1.19 Butanoate metabolism 1 KOX75380.1 Reactome: R-HSA-9636383 Prevention of phagosomal-lysosomal fusion 5 KOX72105.1;KOX71483.1;KOX79430.1;KOX79433.1;KOX67229.1 KEGG: 04070+2.7.1.67 Phosphatidylinositol signaling system 1 KOX79807.1 Reactome: R-HSA-2691232 Constitutive Signaling by NOTCH1 HD Domain Mutants 10 KOX67229.1;KOX72334.1;KOX77003.1;KOX79433.1;KOX79871.1;KOX72702.1;KOX67619.1;KOX72031.1;KOX79430.1;KOX72105.1 KEGG: 00480+1.1.1.42 Glutathione metabolism 1 KOX79046.1 KEGG: 00562+3.1.3.25 Inositol phosphate metabolism 3 KOX71857.1;KOX75545.1;KOX75546.1 KEGG: 00260+5.4.2.11 Glycine, serine and threonine metabolism 1 KOX73085.1 MetaCyc: PWY-4841 UDP-alpha-D-glucuronate biosynthesis (from myo-inositol) 1 KOX74115.1 KEGG: 00230+2.7.1.20 Purine metabolism 1 KOX79221.1 Reactome: R-HSA-5685939 HDR through MMEJ (alt-NHEJ) 7 KOX79317.1;KOX71786.1;KOX80977.1;KOX70179.1;KOX68243.1;KOX68669.1;KOX77633.1 KEGG: 00563+3.5.1.89 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 1 KOX73602.1 Reactome: R-HSA-422085 Synthesis, secretion, and deacylation of Ghrelin 9 KOX77868.1;KOX70692.1;KOX80407.1;KOX77642.1;KOX76114.1;KOX74243.1;KOX77641.1;KOX67929.1;KOX79335.1 Reactome: R-HSA-446199 Synthesis of Dolichyl-phosphate 5 KOX80579.1;KOX81237.1;KOX70726.1;KOX69440.1;KOX67918.1 Reactome: R-HSA-3371568 Attenuation phase 2 KOX76543.1;KOX69665.1 Reactome: R-HSA-8963896 HDL assembly 1 KOX74139.1 Reactome: R-HSA-8964046 VLDL clearance 5 KOX80996.1;KOX73997.1;KOX68248.1;KOX69335.1;KOX73976.1 Reactome: R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 31 KOX79174.1;KOX75272.1;KOX78032.1;KOX67727.1;KOX72302.1;KOX79744.1;KOX81399.1;KOX70684.1;KOX68808.1;KOX72895.1;KOX67865.1;KOX69879.1;KOX70129.1;KOX72162.1;KOX68600.1;KOX72161.1;KOX72163.1;KOX69814.1;KOX74890.1;KOX69543.1;KOX72843.1;KOX77793.1;KOX75316.1;KOX68198.1;KOX72164.1;KOX77029.1;KOX74557.1;KOX72399.1;KOX78763.1;KOX68194.1;KOX75731.1 Reactome: R-HSA-5579007 Defective ACY1 causes encephalopathy 1 KOX69073.1 KEGG: 00260+1.4.4.2 Glycine, serine and threonine metabolism 1 KOX69058.1 Reactome: R-HSA-419771 Opsins 4 KOX69882.1;KOX68034.1;KOX69883.1;KOX79182.1 Reactome: R-HSA-5221030 TET1,2,3 and TDG demethylate DNA 3 KOX75509.1;KOX74010.1;KOX75173.1 Reactome: R-HSA-5545483 Defective Mismatch Repair Associated With MLH1 1 KOX80229.1 KEGG: 00510+2.4.1.256 N-Glycan biosynthesis 1 KOX74903.1 Reactome: R-HSA-9665245 Resistance of ERBB2 KD mutants to tesevatinib 1 KOX73791.1 Reactome: R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere 7 KOX70729.1;KOX74217.1;KOX74214.1;KOX79280.1;KOX77330.1;KOX76500.1;KOX69059.1 Reactome: R-HSA-1266695 Interleukin-7 signaling 2 KOX75547.1;KOX70804.1 KEGG: 00260+2.1.2.1 Glycine, serine and threonine metabolism 1 KOX69033.1 KEGG: 00670+1.5.1.3 One carbon pool by folate 1 KOX80540.1 MetaCyc: PWY-4041 Gamma-glutamyl cycle 4 KOX71346.1;KOX78785.1;KOX79924.1;KOX74355.1 KEGG: 00760+2.3.1.286 Nicotinate and nicotinamide metabolism 6 KOX69603.1;KOX67547.1;KOX79624.1;KOX78237.1;KOX68590.1;KOX72208.1 KEGG: 00520+5.3.1.8 Amino sugar and nucleotide sugar metabolism 1 KOX74805.1 MetaCyc: PWY-6133 (S)-reticuline biosynthesis II 1 KOX71846.1 Reactome: R-HSA-438066 Unblocking of NMDA receptors, glutamate binding and activation 3 KOX68537.1;KOX68226.1;KOX78706.1 Reactome: R-HSA-399997 Acetylcholine regulates insulin secretion 2 KOX75330.1;KOX67567.1 KEGG: 00230+2.4.2.14 Purine metabolism 1 KOX67689.1 Reactome: R-HSA-162710 Synthesis of glycosylphosphatidylinositol (GPI) 15 KOX81358.1;KOX73553.1;KOX76242.1;KOX74389.1;KOX73602.1;KOX67309.1;KOX73635.1;KOX74620.1;KOX71550.1;KOX72990.1;KOX68205.1;KOX72430.1;KOX70375.1;KOX67601.1;KOX69083.1 Reactome: R-HSA-5663220 RHO GTPases Activate Formins 52 KOX71684.1;KOX72164.1;KOX77793.1;KOX76312.1;KOX68498.1;KOX72163.1;KOX72473.1;KOX72161.1;KOX79039.1;KOX69061.1;KOX70129.1;KOX72162.1;KOX69879.1;KOX78693.1;KOX78195.1;KOX77058.1;KOX79744.1;KOX76545.1;KOX72302.1;KOX68210.1;KOX79242.1;KOX71037.1;KOX71089.1;KOX75272.1;KOX81328.1;KOX79174.1;KOX69427.1;KOX72068.1;KOX80793.1;KOX75601.1;KOX81286.1;KOX69417.1;KOX68732.1;KOX72021.1;KOX68198.1;KOX70294.1;KOX76206.1;KOX72843.1;KOX76191.1;KOX76379.1;KOX80503.1;KOX72895.1;KOX77505.1;KOX70729.1;KOX78000.1;KOX69536.1;KOX75211.1;KOX74302.1;KOX78779.1;KOX73340.1;KOX75516.1;KOX74202.1 Reactome: R-HSA-4549356 Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 1 KOX77790.1 Reactome: R-HSA-5140745 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 4 KOX76831.1;KOX69299.1;KOX68797.1;KOX76387.1 Reactome: R-HSA-198323 AKT phosphorylates targets in the cytosol 3 KOX70561.1;KOX80745.1;KOX72400.1 Reactome: R-HSA-1237112 Methionine salvage pathway 4 KOX77097.1;KOX71289.1;KOX79884.1;KOX70443.1 MetaCyc: PWY-7338 10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast) 2 KOX71616.1;KOX73119.1 Reactome: R-HSA-190861 Gap junction assembly 14 KOX75272.1;KOX72163.1;KOX79174.1;KOX72161.1;KOX79744.1;KOX72302.1;KOX77793.1;KOX68198.1;KOX72164.1;KOX72843.1;KOX70129.1;KOX72162.1;KOX69879.1;KOX72895.1 KEGG: 00250+6.3.1.2 Alanine, aspartate and glutamate metabolism 1 KOX75490.1 Reactome: R-HSA-1442490 Collagen degradation 7 KOX75660.1;KOX74957.1;KOX75715.1;KOX76649.1;KOX67619.1;KOX72334.1;KOX75720.1 KEGG: 00230+2.7.4.10 Purine metabolism 1 KOX73294.1 KEGG: 00062+2.3.1.199 Fatty acid elongation 19 KOX78659.1;KOX75202.1;KOX78660.1;KOX78651.1;KOX80068.1;KOX73201.1;KOX68279.1;KOX78713.1;KOX68278.1;KOX78653.1;KOX74597.1;KOX78650.1;KOX78662.1;KOX78657.1;KOX67486.1;KOX67350.1;KOX68696.1;KOX77795.1;KOX78654.1 Reactome: R-HSA-77350 Beta oxidation of hexanoyl-CoA to butanoyl-CoA 1 KOX76405.1 Reactome: R-HSA-977225 Amyloid fiber formation 13 KOX74214.1;KOX78812.1;KOX72105.1;KOX79430.1;KOX74217.1;KOX67229.1;KOX77330.1;KOX81224.1;KOX70021.1;KOX69998.1;KOX68228.1;KOX79433.1;KOX78431.1 Reactome: R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 26 KOX75630.1;KOX79349.1;KOX79436.1;KOX80793.1;KOX72429.1;KOX75539.1;KOX72473.1;KOX69061.1;KOX80341.1;KOX73226.1;KOX68732.1;KOX78183.1;KOX75678.1;KOX73131.1;KOX77058.1;KOX73664.1;KOX77505.1;KOX74908.1;KOX79242.1;KOX68874.1;KOX81376.1;KOX75811.1;KOX75540.1;KOX77867.1;KOX75893.1;KOX74909.1 Reactome: R-HSA-983189 Kinesins 41 KOX70129.1;KOX73046.1;KOX72162.1;KOX74219.1;KOX69879.1;KOX78803.1;KOX70569.1;KOX72302.1;KOX78032.1;KOX77052.1;KOX79744.1;KOX75484.1;KOX79174.1;KOX75272.1;KOX73197.1;KOX69778.1;KOX68474.1;KOX78531.1;KOX77793.1;KOX72164.1;KOX68746.1;KOX72161.1;KOX70429.1;KOX72163.1;KOX72895.1;KOX67776.1;KOX74799.1;KOX74885.1;KOX79827.1;KOX70983.1;KOX75530.1;KOX78475.1;KOX71175.1;KOX80291.1;KOX72556.1;KOX78668.1;KOX68198.1;KOX72843.1;KOX78689.1;KOX73748.1;KOX77968.1 Reactome: R-HSA-418457 cGMP effects 5 KOX68440.1;KOX75450.1;KOX75453.1;KOX72581.1;KOX72584.1 Reactome: R-HSA-8869496 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation 2 KOX67167.1;KOX72944.1 Reactome: R-HSA-5603041 IRAK4 deficiency (TLR2/4) 1 KOX68497.1 MetaCyc: PWY-5971 Palmitate biosynthesis II (bacteria and plant cytoplasm) 2 KOX73549.1;KOX69550.1 Reactome: R-HSA-1483101 Synthesis of PS 1 KOX73187.1 MetaCyc: PWY-7852 6-hydroxymethyl-dihydropterin diphosphate biosynthesis IV (Plasmodium) 1 KOX73788.1 Reactome: R-HSA-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 3 KOX77330.1;KOX74214.1;KOX74217.1 Reactome: R-HSA-210455 Astrocytic Glutamate-Glutamine Uptake And Metabolism 1 KOX75490.1 KEGG: 00940+1.11.1.7 Phenylpropanoid biosynthesis 2 KOX77231.1;KOX69438.1 Reactome: R-HSA-6791462 TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P 1 KOX67931.1 Reactome: R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 11 KOX69868.1;KOX78325.1;KOX73976.1;KOX73997.1;KOX80996.1;KOX72153.1;KOX68929.1;KOX68248.1;KOX69658.1;KOX69335.1;KOX71944.1 Reactome: R-HSA-2408508 Metabolism of ingested SeMet, Sec, MeSec into H2Se 2 KOX69981.1;KOX72452.1 Reactome: R-HSA-167290 Pausing and recovery of HIV elongation 23 KOX75987.1;KOX71506.1;KOX79649.1;KOX77062.1;KOX80159.1;KOX74806.1;KOX70044.1;KOX78553.1;KOX77626.1;KOX77418.1;KOX74945.1;KOX72082.1;KOX67200.1;KOX81395.1;KOX68573.1;KOX70730.1;KOX77063.1;KOX69424.1;KOX78696.1;KOX67799.1;KOX81203.1;KOX67622.1;KOX73198.1 MetaCyc: PWY-5921 Glutaminyl-trnagln biosynthesis via transamidation 1 KOX80357.1 Reactome: R-HSA-167161 HIV Transcription Initiation 29 KOX69085.1;KOX74806.1;KOX74930.1;KOX81403.1;KOX77062.1;KOX68559.1;KOX69897.1;KOX71363.1;KOX79649.1;KOX78263.1;KOX72538.1;KOX77907.1;KOX73785.1;KOX81203.1;KOX73198.1;KOX81398.1;KOX69719.1;KOX74919.1;KOX77063.1;KOX77418.1;KOX71518.1;KOX67200.1;KOX71842.1;KOX77334.1;KOX68729.1;KOX77626.1;KOX69540.1;KOX74030.1;KOX70044.1 Reactome: R-HSA-425393 Transport of inorganic cations/anions and amino acids/oligopeptides 1 KOX78643.1 Reactome: R-HSA-909733 Interferon alpha/beta signaling 1 KOX80002.1 Reactome: R-HSA-198693 AKT phosphorylates targets in the nucleus 2 KOX72400.1;KOX68841.1 Reactome: R-HSA-6787450 tRNA modification in the mitochondrion 8 KOX76584.1;KOX70563.1;KOX71682.1;KOX72874.1;KOX76640.1;KOX76647.1;KOX75975.1;KOX76281.1 Reactome: R-HSA-5696394 DNA Damage Recognition in GG-NER 25 KOX67875.1;KOX74564.1;KOX77633.1;KOX69059.1;KOX79430.1;KOX72890.1;KOX72105.1;KOX67229.1;KOX75604.1;KOX70388.1;KOX70663.1;KOX73551.1;KOX80019.1;KOX71193.1;KOX78340.1;KOX79999.1;KOX72917.1;KOX73447.1;KOX68759.1;KOX72436.1;KOX79869.1;KOX69259.1;KOX73512.1;KOX67173.1;KOX79433.1 MetaCyc: PWY-6907 Thiamine diphosphate biosynthesis III (Staphylococcus) 1 KOX78326.1 KEGG: 00670+6.3.4.3 One carbon pool by folate 3 KOX77269.1;KOX69389.1;KOX69388.1 MetaCyc: PWY-6619 Adenine and adenosine salvage VI 1 KOX79221.1 KEGG: 00460+2.1.2.1 Cyanoamino acid metabolism 1 KOX69033.1 Reactome: R-HSA-190840 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 14 KOX79744.1;KOX72302.1;KOX77793.1;KOX72164.1;KOX68198.1;KOX72843.1;KOX75272.1;KOX72163.1;KOX79174.1;KOX72161.1;KOX70129.1;KOX72162.1;KOX69879.1;KOX72895.1 Reactome: R-HSA-113507 E2F-enabled inhibition of pre-replication complex formation 5 KOX79615.1;KOX70456.1;KOX67686.1;KOX69890.1;KOX73262.1 Reactome: R-HSA-110357 Displacement of DNA glycosylase by APEX1 7 KOX77974.1;KOX67788.1;KOX77492.1;KOX75509.1;KOX70328.1;KOX77019.1;KOX74010.1 Reactome: R-HSA-8951664 Neddylation 93 KOX78786.1;KOX75791.1;KOX77271.1;KOX79045.1;KOX67622.1;KOX72982.1;KOX80285.1;KOX79230.1;KOX67977.1;KOX79601.1;KOX67195.1;KOX70419.1;KOX70394.1;KOX80356.1;KOX72890.1;KOX70327.1;KOX72917.1;KOX76219.1;KOX78273.1;KOX69414.1;KOX77407.1;KOX79626.1;KOX80008.1;KOX74779.1;KOX67229.1;KOX74169.1;KOX72371.1;KOX76009.1;KOX70009.1;KOX72232.1;KOX71457.1;KOX69884.1;KOX72411.1;KOX68314.1;KOX70598.1;KOX68524.1;KOX79430.1;KOX76879.1;KOX74011.1;KOX73209.1;KOX74924.1;KOX75675.1;KOX80582.1;KOX72468.1;KOX70425.1;KOX74996.1;KOX72095.1;KOX71752.1;KOX71606.1;KOX68313.1;KOX76621.1;KOX69458.1;KOX70383.1;KOX79363.1;KOX77941.1;KOX70663.1;KOX70388.1;KOX73551.1;KOX67875.1;KOX73641.1;KOX72783.1;KOX72105.1;KOX69259.1;KOX74347.1;KOX73512.1;KOX69759.1;KOX80756.1;KOX68748.1;KOX69333.1;KOX78292.1;KOX70760.1;KOX68215.1;KOX75968.1;KOX71193.1;KOX68786.1;KOX67905.1;KOX76416.1;KOX73060.1;KOX73679.1;KOX72753.1;KOX72082.1;KOX76213.1;KOX78266.1;KOX79600.1;KOX76794.1;KOX75984.1;KOX74910.1;KOX79207.1;KOX69688.1;KOX79433.1;KOX75318.1;KOX68530.1;KOX78268.1 KEGG: 00730+2.8.1.7 Thiamine metabolism 1 KOX69261.1 KEGG: 00450+1.8.1.9 Selenocompound metabolism 1 KOX75405.1 MetaCyc: PWY-622 Starch biosynthesis 3 KOX70625.1;KOX67919.1;KOX68382.1 Reactome: R-HSA-8853334 Signaling by FGFR3 fusions in cancer 1 KOX81204.1 KEGG: 00565+3.1.4.4 Ether lipid metabolism 1 KOX74104.1 KEGG: 00520+2.7.7.9 Amino sugar and nucleotide sugar metabolism 1 KOX67374.1 Reactome: R-HSA-174414 Processive synthesis on the C-strand of the telomere 4 KOX77326.1;KOX78024.1;KOX77356.1;KOX81364.1 MetaCyc: PWY-5172 Acetyl-coa biosynthesis III (from citrate) 1 KOX74316.1 Reactome: R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance 29 KOX77907.1;KOX73785.1;KOX71363.1;KOX79649.1;KOX78263.1;KOX72538.1;KOX77062.1;KOX81403.1;KOX68559.1;KOX69897.1;KOX69085.1;KOX74806.1;KOX74930.1;KOX77334.1;KOX68729.1;KOX77626.1;KOX69540.1;KOX70044.1;KOX74030.1;KOX71518.1;KOX77418.1;KOX67200.1;KOX71842.1;KOX81398.1;KOX74919.1;KOX69719.1;KOX77063.1;KOX81203.1;KOX73198.1 Reactome: R-HSA-8937144 Aryl hydrocarbon receptor signalling 2 KOX67402.1;KOX76141.1 KEGG: 00970+6.1.1.3 Aminoacyl-tRNA biosynthesis 5 KOX71118.1;KOX80757.1;KOX68920.1;KOX72930.1;KOX80468.1 Reactome: R-HSA-5654699 SHC-mediated cascade:FGFR2 1 KOX81204.1 KEGG: 00970+6.1.1.14 Aminoacyl-tRNA biosynthesis 2 KOX80113.1;KOX72994.1 Reactome: R-HSA-428890 Role of ABL in ROBO-SLIT signaling 2 KOX78150.1;KOX80895.1 KEGG: 00620+1.1.1.27 Pyruvate metabolism 2 KOX77687.1;KOX77688.1 Reactome: R-HSA-6787639 GDP-fucose biosynthesis 3 KOX72980.1;KOX69413.1;KOX79925.1 KEGG: 00010+2.7.1.11 Glycolysis / Gluconeogenesis 1 KOX67867.1 Reactome: R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 20 KOX69061.1;KOX72473.1;KOX78183.1;KOX73226.1;KOX80341.1;KOX68732.1;KOX80793.1;KOX79436.1;KOX75630.1;KOX75539.1;KOX72429.1;KOX68874.1;KOX81376.1;KOX75811.1;KOX79242.1;KOX75540.1;KOX77058.1;KOX73131.1;KOX77505.1;KOX73664.1 KEGG: 00400+2.6.1.1 Phenylalanine, tyrosine and tryptophan biosynthesis 2 KOX71428.1;KOX79912.1 Reactome: R-HSA-112382 Formation of RNA Pol II elongation complex 42 KOX74909.1;KOX71506.1;KOX73785.1;KOX79649.1;KOX77062.1;KOX74916.1;KOX74908.1;KOX74030.1;KOX78553.1;KOX80906.1;KOX77418.1;KOX75631.1;KOX67200.1;KOX72082.1;KOX73587.1;KOX74919.1;KOX69719.1;KOX69424.1;KOX67799.1;KOX79279.1;KOX81203.1;KOX72967.1;KOX75987.1;KOX72538.1;KOX81403.1;KOX69309.1;KOX69897.1;KOX73186.1;KOX80159.1;KOX74806.1;KOX69540.1;KOX70044.1;KOX77626.1;KOX74945.1;KOX81395.1;KOX77063.1;KOX68573.1;KOX70730.1;KOX70864.1;KOX78696.1;KOX67622.1;KOX73198.1 Reactome: R-HSA-418990 Adherens junctions interactions 2 KOX67713.1;KOX80436.1 KEGG: 00780+6.3.4.15 Biotin metabolism 1 KOX79449.1 Reactome: R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) 25 KOX79174.1;KOX75989.1;KOX75272.1;KOX72302.1;KOX76543.1;KOX79744.1;KOX75211.1;KOX78693.1;KOX72895.1;KOX72469.1;KOX70129.1;KOX72162.1;KOX69879.1;KOX72161.1;KOX72163.1;KOX68198.1;KOX77793.1;KOX72164.1;KOX71404.1;KOX69877.1;KOX72843.1;KOX75429.1;KOX72021.1;KOX68241.1;KOX80782.1 KEGG: 00052+3.2.1.22 Galactose metabolism 1 KOX70065.1 Reactome: R-HSA-5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 9 KOX77326.1;KOX78024.1;KOX68230.1;KOX70744.1;KOX70402.1;KOX72417.1;KOX80229.1;KOX81364.1;KOX77356.1 KEGG: 00230+2.7.1.40 Purine metabolism 2 KOX74974.1;KOX74975.1 MetaCyc: PWY-7176 UTP and CTP de novo biosynthesis 6 KOX71458.1;KOX78412.1;KOX76865.1;KOX78158.1;KOX77775.1;KOX75796.1 MetaCyc: PWY-922 Mevalonate pathway I 4 KOX74855.1;KOX70405.1;KOX69440.1;KOX70146.1 MetaCyc: PWY-7112 4-hydroxy-2-nonenal detoxification 6 KOX69433.1;KOX79924.1;KOX71878.1;KOX78785.1;KOX71346.1;KOX71611.1 KEGG: 00790+1.14.16.1 Folate biosynthesis 1 KOX77562.1 Reactome: R-HSA-210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 4 KOX71242.1;KOX69665.1;KOX67158.1;KOX69604.1 KEGG: 00531+3.2.1.50 Glycosaminoglycan degradation 1 KOX75831.1 Reactome: R-HSA-5654704 SHC-mediated cascade:FGFR3 1 KOX81204.1 Reactome: R-HSA-3134973 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production 1 KOX69665.1 KEGG: 00510+2.4.1.259+2.4.1.261 N-Glycan biosynthesis 1 KOX76984.1 Reactome: R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase 9 KOX71898.1;KOX79389.1;KOX72154.1;KOX71992.1;KOX73267.1;KOX72749.1;KOX74256.1;KOX76210.1;KOX76684.1 KEGG: 00061+1.1.1.100+2.3.1.85+4.2.1.59+2.3.1.39+2.3.1.41+3.1.2.14 Fatty acid biosynthesis 2 KOX69550.1;KOX73549.1 KEGG: 00010+1.1.1.27 Glycolysis / Gluconeogenesis 2 KOX77687.1;KOX77688.1 Reactome: R-HSA-111465 Apoptotic cleavage of cellular proteins 4 KOX78564.1;KOX75506.1;KOX75788.1;KOX73320.1 KEGG: 00564+2.3.1.51 Glycerophospholipid metabolism 4 KOX77858.1;KOX75990.1;KOX67923.1;KOX79114.1 Reactome: R-HSA-2142789 Ubiquinol biosynthesis 6 KOX72023.1;KOX77776.1;KOX77408.1;KOX78758.1;KOX75964.1;KOX70323.1 Reactome: R-HSA-71336 Pentose phosphate pathway 6 KOX78189.1;KOX81368.1;KOX80223.1;KOX67931.1;KOX72985.1;KOX77910.1 Reactome: R-HSA-428540 Activation of RAC1 3 KOX71656.1;KOX68084.1;KOX76214.1 Reactome: R-HSA-110362 POLB-Dependent Long Patch Base Excision Repair 5 KOX78692.1;KOX70179.1;KOX77974.1;KOX67874.1;KOX77633.1 Reactome: R-HSA-156590 Glutathione conjugation 5 KOX69433.1;KOX71878.1;KOX71039.1;KOX71611.1;KOX75486.1 MetaCyc: PWY-5497 Purine nucleobases degradation II (anaerobic) 5 KOX77269.1;KOX71781.1;KOX69033.1;KOX73844.1;KOX67514.1 Reactome: R-HSA-8851680 Butyrophilin (BTN) family interactions 1 KOX71781.1 Reactome: R-HSA-446203 Asparagine N-linked glycosylation 5 KOX71198.1;KOX67340.1;KOX67259.1;KOX75568.1;KOX67830.1 Reactome: R-HSA-167590 Nef Mediated CD4 Down-regulation 3 KOX68797.1;KOX76387.1;KOX69299.1 KEGG: 00400+1.14.16.1 Phenylalanine, tyrosine and tryptophan biosynthesis 1 KOX77562.1 MetaCyc: PWY-7174 S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation II 4 KOX72189.1;KOX70443.1;KOX72835.1;KOX73121.1 KEGG: 00020+1.8.1.4 Citrate cycle (TCA cycle) 1 KOX75086.1 KEGG: 00220+6.3.1.2 Arginine biosynthesis 1 KOX75490.1 KEGG: 00680+2.1.2.1 Methane metabolism 1 KOX69033.1 Reactome: R-HSA-1482839 Acyl chain remodelling of PE 5 KOX72448.1;KOX69497.1;KOX75783.1;KOX69576.1;KOX79218.1 KEGG: 00970+6.1.1.16 Aminoacyl-tRNA biosynthesis 2 KOX75932.1;KOX76815.1 Reactome: R-HSA-168276 NS1 Mediated Effects on Host Pathways 22 KOX80793.1;KOX79436.1;KOX75630.1;KOX75539.1;KOX72429.1;KOX69061.1;KOX75105.1;KOX72473.1;KOX78183.1;KOX68732.1;KOX73226.1;KOX80341.1;KOX77058.1;KOX71677.1;KOX73131.1;KOX77505.1;KOX73664.1;KOX81376.1;KOX68874.1;KOX75811.1;KOX79242.1;KOX75540.1 Reactome: R-HSA-5654688 SHC-mediated cascade:FGFR1 1 KOX81204.1 MetaCyc: PWY-5080 Very long chain fatty acid biosynthesis I 21 KOX80068.1;KOX78651.1;KOX78660.1;KOX75202.1;KOX78659.1;KOX74597.1;KOX68278.1;KOX78653.1;KOX68279.1;KOX73201.1;KOX78713.1;KOX78236.1;KOX67486.1;KOX79701.1;KOX78657.1;KOX78662.1;KOX78650.1;KOX78654.1;KOX77795.1;KOX67350.1;KOX68696.1 Reactome: R-HSA-975871 MyD88 cascade initiated on plasma membrane 2 KOX74914.1;KOX68497.1 KEGG: 00600+3.2.1.22 Sphingolipid metabolism 1 KOX70065.1 Reactome: R-HSA-75896 Plasmalogen biosynthesis 1 KOX77488.1 KEGG: 00330+1.14.13.39 Arginine and proline metabolism 1 KOX68681.1 KEGG: 00230+1.17.4.1 Purine metabolism 1 KOX79885.1 MetaCyc: PWY-7288 Fatty acid beta-oxidation VII (yeast peroxisome) 2 KOX71616.1;KOX73119.1 MetaCyc: PWY-7379 Mrna capping II 1 KOX81002.1 Reactome: R-HSA-8939245 RUNX1 regulates transcription of genes involved in BCR signaling 1 KOX79878.1 Reactome: R-HSA-877300 Interferon gamma signaling 3 KOX72900.1;KOX78534.1;KOX68226.1 KEGG: 00620+2.7.1.40 Pyruvate metabolism 2 KOX74975.1;KOX74974.1 Reactome: R-HSA-5654733 Negative regulation of FGFR4 signaling 6 KOX81204.1;KOX68500.1;KOX67229.1;KOX72105.1;KOX79430.1;KOX79433.1 Reactome: R-HSA-392154 Nitric oxide stimulates guanylate cyclase 5 KOX76795.1;KOX71960.1;KOX68681.1;KOX70464.1;KOX76796.1 Reactome: R-HSA-5358606 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 8 KOX72417.1;KOX80229.1;KOX81364.1;KOX77356.1;KOX77326.1;KOX78024.1;KOX70402.1;KOX70744.1 Reactome: R-HSA-77111 Synthesis of Ketone Bodies 1 KOX72741.1 Reactome: R-HSA-1663150 The activation of arylsulfatases 1 KOX76185.1 Reactome: R-HSA-427975 Proton/oligopeptide cotransporters 1 KOX78297.1 Reactome: R-HSA-426117 Cation-coupled Chloride cotransporters 4 KOX68349.1;KOX69963.1;KOX71575.1;KOX75298.1 KEGG: 00040+2.7.7.9 Pentose and glucuronate interconversions 1 KOX67374.1 Reactome: R-HSA-68827 CDT1 association with the CDC6:ORC:origin complex 46 KOX67229.1;KOX76416.1;KOX73060.1;KOX76009.1;KOX70009.1;KOX70598.1;KOX68314.1;KOX72411.1;KOX79430.1;KOX78266.1;KOX76879.1;KOX67686.1;KOX81352.1;KOX79615.1;KOX73209.1;KOX70456.1;KOX74011.1;KOX74924.1;KOX69890.1;KOX79433.1;KOX75984.1;KOX74910.1;KOX80582.1;KOX71606.1;KOX72468.1;KOX78268.1;KOX70383.1;KOX78786.1;KOX68313.1;KOX76415.1;KOX72982.1;KOX77271.1;KOX79363.1;KOX79230.1;KOX70419.1;KOX72105.1;KOX79601.1;KOX69414.1;KOX78273.1;KOX68748.1;KOX69333.1;KOX75968.1;KOX70760.1;KOX80008.1;KOX79626.1;KOX73262.1 Reactome: R-HSA-3359471 Defective MMAB causes methylmalonic aciduria type cblB 1 KOX67948.1 Reactome: R-HSA-2467813 Separation of Sister Chromatids 99 KOX70760.1;KOX72302.1;KOX76545.1;KOX68210.1;KOX75968.1;KOX79744.1;KOX74256.1;KOX78195.1;KOX69333.1;KOX68748.1;KOX78693.1;KOX77793.1;KOX72164.1;KOX73267.1;KOX72161.1;KOX69061.1;KOX72105.1;KOX76312.1;KOX68498.1;KOX68313.1;KOX70383.1;KOX79363.1;KOX76210.1;KOX73340.1;KOX74302.1;KOX78268.1;KOX70177.1;KOX74202.1;KOX77505.1;KOX72895.1;KOX77869.1;KOX70729.1;KOX74910.1;KOX75984.1;KOX78000.1;KOX79433.1;KOX81286.1;KOX72021.1;KOX68732.1;KOX69417.1;KOX76379.1;KOX78266.1;KOX73060.1;KOX76416.1;KOX76684.1;KOX72068.1;KOX75601.1;KOX79174.1;KOX81328.1;KOX74954.1;KOX79626.1;KOX80008.1;KOX71037.1;KOX79242.1;KOX71089.1;KOX79053.1;KOX75272.1;KOX78273.1;KOX72162.1;KOX70129.1;KOX69414.1;KOX69879.1;KOX77058.1;KOX79230.1;KOX71898.1;KOX79601.1;KOX79039.1;KOX72163.1;KOX70419.1;KOX72473.1;KOX78786.1;KOX77271.1;KOX72982.1;KOX80582.1;KOX71992.1;KOX75516.1;KOX72468.1;KOX71606.1;KOX79389.1;KOX74011.1;KOX73209.1;KOX80503.1;KOX72749.1;KOX75211.1;KOX69536.1;KOX74924.1;KOX72411.1;KOX68198.1;KOX68314.1;KOX68193.1;KOX72843.1;KOX72154.1;KOX70598.1;KOX76879.1;KOX79430.1;KOX67229.1;KOX70009.1;KOX76009.1;KOX80793.1 Reactome: R-HSA-9022538 Loss of MECP2 binding ability to 5mC-DNA 1 KOX71680.1 Reactome: R-HSA-2979096 NOTCH2 Activation and Transmission of Signal to the Nucleus 12 KOX77003.1;KOX67229.1;KOX70021.1;KOX69998.1;KOX68228.1;KOX79433.1;KOX77051.1;KOX72702.1;KOX79871.1;KOX72105.1;KOX72031.1;KOX79430.1 KEGG: 00564+1.1.1.8 Glycerophospholipid metabolism 2 KOX75460.1;KOX75465.1 KEGG: 00030+1.1.1.49 Pentose phosphate pathway 1 KOX73807.1 Reactome: R-HSA-4719377 Defective DPM2 causes DPM2-CDG (CDG-1u) 3 KOX72243.1;KOX73553.1;KOX78339.1 MetaCyc: PWY-6627 Salinosporamide A biosynthesis 1 KOX78203.1 KEGG: 00562+3.1.4.11 Inositol phosphate metabolism 4 KOX74728.1;KOX71582.1;KOX75330.1;KOX74989.1 Reactome: R-HSA-211733 Regulation of activated PAK-2p34 by proteasome mediated degradation 39 KOX76416.1;KOX67229.1;KOX73060.1;KOX76009.1;KOX70009.1;KOX70598.1;KOX68314.1;KOX72411.1;KOX79430.1;KOX78266.1;KOX76879.1;KOX73209.1;KOX74011.1;KOX74924.1;KOX79433.1;KOX75984.1;KOX74910.1;KOX80582.1;KOX71606.1;KOX72468.1;KOX78268.1;KOX70383.1;KOX78786.1;KOX68313.1;KOX72982.1;KOX79363.1;KOX77271.1;KOX79230.1;KOX70419.1;KOX72105.1;KOX79601.1;KOX69414.1;KOX78273.1;KOX68748.1;KOX69333.1;KOX75968.1;KOX70760.1;KOX80008.1;KOX79626.1 Reactome: R-HSA-3000178 ECM proteoglycans 5 KOX80772.1;KOX75715.1;KOX78294.1;KOX70849.1;KOX75720.1 Reactome: R-HSA-5654727 Negative regulation of FGFR2 signaling 6 KOX72105.1;KOX79430.1;KOX79433.1;KOX68500.1;KOX67229.1;KOX81204.1 Reactome: R-HSA-163358 PKA-mediated phosphorylation of key metabolic factors 1 KOX74139.1 KEGG: 00531+3.2.1.52 Glycosaminoglycan degradation 4 KOX74395.1;KOX74285.1;KOX73530.1;KOX74631.1 MetaCyc: PWY-1622 Formaldehyde assimilation I (serine pathway) 9 KOX69541.1;KOX70049.1;KOX81104.1;KOX68928.1;KOX70050.1;KOX69033.1;KOX75374.1;KOX71859.1;KOX73085.1 Reactome: R-HSA-8939247 RUNX1 regulates transcription of genes involved in interleukin signaling 1 KOX79878.1 MetaCyc: PWY-6802 Salidroside biosynthesis 1 KOX67600.1 KEGG: 00020+2.3.3.8 Citrate cycle (TCA cycle) 1 KOX74316.1 Reactome: R-HSA-170968 Frs2-mediated activation 1 KOX68500.1 KEGG: 00900+2.7.4.2 Terpenoid backbone biosynthesis 1 KOX70146.1 Reactome: R-HSA-75893 TNF signaling 1 KOX67619.1 Reactome: R-HSA-166208 mTORC1-mediated signalling 15 KOX72777.1;KOX74358.1;KOX68085.1;KOX78813.1;KOX79033.1;KOX69831.1;KOX68213.1;KOX72912.1;KOX73089.1;KOX78128.1;KOX73869.1;KOX80754.1;KOX67725.1;KOX67237.1;KOX68086.1 KEGG: 00592+3.1.1.4 alpha-Linolenic acid metabolism 10 KOX78316.1;KOX79218.1;KOX69497.1;KOX78399.1;KOX77917.1;KOX72448.1;KOX70330.1;KOX78275.1;KOX69576.1;KOX75783.1 Reactome: R-HSA-3656253 Defective EXT1 causes exostoses 1, TRPS2 and CHDS 6 KOX80363.1;KOX77892.1;KOX73118.1;KOX74836.1;KOX80364.1;KOX76492.1 Reactome: R-HSA-9665247 Resistance of ERBB2 KD mutants to osimertinib 1 KOX73791.1 Reactome: R-HSA-381033 ATF6 (ATF6-alpha) activates chaperones 2 KOX73944.1;KOX79365.1 KEGG: 00513+2.4.1.258 Various types of N-glycan biosynthesis 1 KOX71269.1 Reactome: R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 46 KOX69879.1;KOX70129.1;KOX72162.1;KOX77058.1;KOX78195.1;KOX78693.1;KOX68210.1;KOX72302.1;KOX76545.1;KOX79744.1;KOX81328.1;KOX79174.1;KOX71089.1;KOX79242.1;KOX71037.1;KOX75272.1;KOX77793.1;KOX72164.1;KOX69061.1;KOX79039.1;KOX72161.1;KOX72163.1;KOX72473.1;KOX76312.1;KOX68498.1;KOX70729.1;KOX72895.1;KOX77505.1;KOX80503.1;KOX69536.1;KOX75211.1;KOX78000.1;KOX73340.1;KOX74302.1;KOX74202.1;KOX75516.1;KOX75601.1;KOX80793.1;KOX72068.1;KOX72843.1;KOX68198.1;KOX72021.1;KOX68732.1;KOX69417.1;KOX81286.1;KOX76379.1 Reactome: R-HSA-8964038 LDL clearance 14 KOX74661.1;KOX69299.1;KOX69335.1;KOX75392.1;KOX68797.1;KOX76387.1;KOX81109.1;KOX73976.1;KOX78887.1;KOX77076.1;KOX79311.1;KOX68248.1;KOX80996.1;KOX73997.1 KEGG: 00250+4.3.2.2 Alanine, aspartate and glutamate metabolism 1 KOX71530.1 Reactome: R-HSA-3560801 Defective B3GAT3 causes JDSSDHD 4 KOX80363.1;KOX76492.1;KOX80364.1;KOX73118.1 KEGG: 00030+2.7.6.1 Pentose phosphate pathway 2 KOX69375.1;KOX68809.1 KEGG: 00270+2.6.1.1 Cysteine and methionine metabolism 2 KOX71428.1;KOX79912.1 MetaCyc: PWY-6692 Fe(II) oxidation 1 KOX76195.1 MetaCyc: PWY-1801 Formaldehyde oxidation II (glutathione-dependent) 2 KOX67600.1;KOX75486.1 MetaCyc: PWY-5872 Ubiquinol-10 biosynthesis (eukaryotic) 3 KOX70323.1;KOX72023.1;KOX77776.1 Reactome: R-HSA-8850843 Phosphate bond hydrolysis by NTPDase proteins 1 KOX74586.1 Reactome: R-HSA-3899300 SUMOylation of transcription cofactors 6 KOX68237.1;KOX69665.1;KOX75480.1;KOX75920.1;KOX71680.1;KOX74322.1 KEGG: 00380+4.2.1.17+1.1.1.35 Tryptophan metabolism 2 KOX76405.1;KOX75101.1 MetaCyc: PWY-4984 Urea cycle 2 KOX81392.1;KOX69117.1 Reactome: R-HSA-6790901 rRNA modification in the nucleus and cytosol 42 KOX74453.1;KOX74452.1;KOX73225.1;KOX78747.1;KOX79914.1;KOX76264.1;KOX67169.1;KOX76435.1;KOX76834.1;KOX76902.1;KOX80007.1;KOX80761.1;KOX79371.1;KOX73649.1;KOX78354.1;KOX68996.1;KOX79381.1;KOX67718.1;KOX77066.1;KOX72944.1;KOX71988.1;KOX70721.1;KOX68061.1;KOX68173.1;KOX67355.1;KOX67731.1;KOX75227.1;KOX78381.1;KOX67872.1;KOX78543.1;KOX73841.1;KOX69622.1;KOX69115.1;KOX70863.1;KOX69407.1;KOX76308.1;KOX71955.1;KOX74996.1;KOX67237.1;KOX79162.1;KOX72904.1;KOX67795.1 Reactome: R-HSA-1482925 Acyl chain remodelling of PG 5 KOX79218.1;KOX69576.1;KOX75783.1;KOX69497.1;KOX72448.1 Reactome: R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 46 KOX78273.1;KOX69414.1;KOX81403.1;KOX68748.1;KOX69333.1;KOX80895.1;KOX70760.1;KOX74214.1;KOX75968.1;KOX79626.1;KOX72538.1;KOX80008.1;KOX78786.1;KOX68313.1;KOX70383.1;KOX79878.1;KOX77330.1;KOX77271.1;KOX79363.1;KOX72982.1;KOX79230.1;KOX79601.1;KOX70419.1;KOX72105.1;KOX74217.1;KOX74011.1;KOX73209.1;KOX75984.1;KOX74910.1;KOX79433.1;KOX74924.1;KOX80582.1;KOX72468.1;KOX78268.1;KOX71606.1;KOX67229.1;KOX76416.1;KOX73060.1;KOX76009.1;KOX70009.1;KOX68314.1;KOX72411.1;KOX70598.1;KOX79430.1;KOX76879.1;KOX78266.1 Reactome: R-HSA-380259 Loss of Nlp from mitotic centrosomes 17 KOX72931.1;KOX76822.1;KOX70798.1;KOX68021.1;KOX75516.1;KOX80122.1;KOX75699.1;KOX69780.1;KOX75559.1;KOX73591.1;KOX79004.1;KOX78488.1;KOX73600.1;KOX76312.1;KOX71404.1;KOX69877.1;KOX75429.1 KEGG: 00830+1.1.1.1 Retinol metabolism 1 KOX67600.1 KEGG: 00480+1.17.4.1 Glutathione metabolism 1 KOX79885.1 MetaCyc: PWY-7396 Butanol and isobutanol biosynthesis (engineered) 1 KOX67600.1 Reactome: R-HSA-8849469 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 4 KOX67229.1;KOX79430.1;KOX79433.1;KOX72105.1 KEGG: 00650+4.1.3.4 Butanoate metabolism 1 KOX72741.1 Reactome: R-HSA-71737 Pyrophosphate hydrolysis 1 KOX68266.1 Reactome: R-HSA-68952 DNA replication initiation 7 KOX69330.1;KOX77830.1;KOX79678.1;KOX78863.1;KOX78132.1;KOX81161.1;KOX77276.1 KEGG: 00450+2.7.9.3 Selenocompound metabolism 1 KOX73295.1 Reactome: R-HSA-2424491 DAP12 signaling 2 KOX81204.1;KOX71582.1 Reactome: R-HSA-70268 Pyruvate metabolism 9 KOX75086.1;KOX77688.1;KOX74119.1;KOX79834.1;KOX77687.1;KOX73783.1;KOX78471.1;KOX76243.1;KOX70042.1 Reactome: R-HSA-350054 Notch-HLH transcription pathway 7 KOX69108.1;KOX74673.1;KOX72040.1;KOX71242.1;KOX67158.1;KOX79254.1;KOX69604.1 MetaCyc: PWY-5331 Taurine biosynthesis I 1 KOX69327.1 KEGG: 00620+4.1.1.32 Pyruvate metabolism 1 KOX68597.1 MetaCyc: PWY-4302 Aerobic respiration III (alternative oxidase pathway) 2 KOX68680.1;KOX79955.1 KEGG: 00966+2.6.1.42 Glucosinolate biosynthesis 1 KOX72274.1 Reactome: R-HSA-9634635 Estrogen-stimulated signaling through PRKCZ 1 KOX78362.1 Reactome: R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer 8 KOX78362.1;KOX78813.1;KOX79033.1;KOX80745.1;KOX68841.1;KOX72400.1;KOX70561.1;KOX72981.1 Reactome: R-HSA-2514853 Condensation of Prometaphase Chromosomes 6 KOX79369.1;KOX78117.1;KOX77060.1;KOX75145.1;KOX74623.1;KOX70292.1 Reactome: R-HSA-9633012 Response of EIF2AK4 (GCN2) to amino acid deficiency 81 KOX73344.1;KOX79160.1;KOX67361.1;KOX71651.1;KOX75227.1;KOX80864.1;KOX77016.1;KOX70024.1;KOX79738.1;KOX79433.1;KOX76900.1;KOX78568.1;KOX75432.1;KOX72125.1;KOX75945.1;KOX72904.1;KOX67237.1;KOX74407.1;KOX81388.1;KOX74170.1;KOX79914.1;KOX69807.1;KOX72644.1;KOX74668.1;KOX67280.1;KOX77134.1;KOX72105.1;KOX73982.1;KOX81215.1;KOX72660.1;KOX78350.1;KOX71077.1;KOX75483.1;KOX76065.1;KOX72185.1;KOX75024.1;KOX70174.1;KOX75797.1;KOX74357.1;KOX74637.1;KOX77911.1;KOX81040.1;KOX68431.1;KOX71988.1;KOX67699.1;KOX67229.1;KOX71403.1;KOX75143.1;KOX69818.1;KOX77188.1;KOX70176.1;KOX72330.1;KOX79611.1;KOX67935.1;KOX79430.1;KOX81212.1;KOX70147.1;KOX67698.1;KOX72074.1;KOX73308.1;KOX75958.1;KOX67807.1;KOX71394.1;KOX71471.1;KOX70724.1;KOX78800.1;KOX67795.1;KOX73889.1;KOX70175.1;KOX73120.1;KOX78826.1;KOX67227.1;KOX78670.1;KOX75358.1;KOX70874.1;KOX68107.1;KOX68744.1;KOX74804.1;KOX78289.1;KOX73450.1;KOX68042.1 KEGG: 00230+3.6.1.17 Purine metabolism 1 KOX76220.1 Reactome: R-HSA-5689603 UCH proteinases 55 KOX76416.1;KOX67229.1;KOX73060.1;KOX76009.1;KOX70009.1;KOX80019.1;KOX72411.1;KOX68314.1;KOX70598.1;KOX79430.1;KOX78266.1;KOX76879.1;KOX74011.1;KOX79869.1;KOX68759.1;KOX73209.1;KOX75984.1;KOX74910.1;KOX74924.1;KOX68335.1;KOX79433.1;KOX68988.1;KOX80582.1;KOX80322.1;KOX72468.1;KOX78268.1;KOX71606.1;KOX78786.1;KOX78410.1;KOX68313.1;KOX75604.1;KOX70383.1;KOX79363.1;KOX77271.1;KOX68990.1;KOX71866.1;KOX72982.1;KOX79230.1;KOX74564.1;KOX75013.1;KOX79601.1;KOX69059.1;KOX70419.1;KOX72105.1;KOX78273.1;KOX69414.1;KOX72436.1;KOX67173.1;KOX68748.1;KOX69333.1;KOX70760.1;KOX75968.1;KOX79626.1;KOX79999.1;KOX80008.1 Reactome: R-HSA-173599 Formation of the active cofactor, UDP-glucuronate 2 KOX67374.1;KOX69806.1 Reactome: R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs 35 KOX67719.1;KOX75941.1;KOX68110.1;KOX77542.1;KOX68766.1;KOX72471.1;KOX80449.1;KOX70400.1;KOX79902.1;KOX68424.1;KOX67228.1;KOX72943.1;KOX71400.1;KOX80373.1;KOX67970.1;KOX80371.1;KOX69686.1;KOX73747.1;KOX75731.1;KOX77980.1;KOX75792.1;KOX70722.1;KOX80690.1;KOX71885.1;KOX71463.1;KOX72238.1;KOX70568.1;KOX73887.1;KOX71647.1;KOX67949.1;KOX79785.1;KOX72400.1;KOX72665.1;KOX72237.1;KOX77544.1 Reactome: R-HSA-9634285 Constitutive Signaling by Overexpressed ERBB2 2 KOX81204.1;KOX73791.1 KEGG: 00980+2.5.1.18 Metabolism of xenobiotics by cytochrome P450 3 KOX71611.1;KOX69433.1;KOX71878.1 MetaCyc: PWY-6708 Ubiquinol-8 biosynthesis (prokaryotic) 3 KOX77776.1;KOX72023.1;KOX70323.1 KEGG: 00564+3.1.1.7 Glycerophospholipid metabolism 1 KOX70692.1 MetaCyc: PWY-6344 L-ornithine degradation II (Stickland reaction) 3 KOX79798.1;KOX70089.1;KOX79797.1 Reactome: R-HSA-1810476 RIP-mediated NFkB activation via ZBP1 2 KOX68497.1;KOX72966.1 Reactome: R-HSA-8948700 Competing endogenous RNAs (ceRNAs) regulate PTEN translation 5 KOX67889.1;KOX68332.1;KOX74484.1;KOX74580.1;KOX70201.1 Reactome: R-HSA-170660 Adenylate cyclase activating pathway 3 KOX73149.1;KOX69402.1;KOX78138.1 Reactome: R-HSA-4420097 VEGFA-VEGFR2 Pathway 15 KOX73800.1;KOX80062.1;KOX76191.1;KOX71656.1;KOX78337.1;KOX71145.1;KOX79097.1;KOX78779.1;KOX69804.1;KOX72079.1;KOX76112.1;KOX78334.1;KOX74139.1;KOX72811.1;KOX76825.1 Reactome: R-HSA-5654689 PI-3K cascade:FGFR1 1 KOX81204.1 Reactome: R-HSA-110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway 1 KOX77974.1 MetaCyc: PWY-6348 Phosphate acquisition 9 KOX74329.1;KOX73843.1;KOX75677.1;KOX79542.1;KOX80575.1;KOX73842.1;KOX69530.1;KOX80576.1;KOX80574.1 MetaCyc: PWY-5941 Glycogen degradation II 2 KOX80377.1;KOX74487.1 KEGG: 00051+5.3.1.6 Fructose and mannose metabolism 1 KOX80223.1 KEGG: 00410+4.1.1.9 beta-Alanine metabolism 1 KOX72779.1 Reactome: R-HSA-5620916 VxPx cargo-targeting to cilium 7 KOX68808.1;KOX67727.1;KOX78763.1;KOX72399.1;KOX77029.1;KOX74557.1;KOX81399.1 KEGG: 04151+2.7.11.1 PI3K-Akt signaling pathway 40 KOX79225.1;KOX69995.1;KOX73463.1;KOX72400.1;KOX79935.1;KOX70676.1;KOX76221.1;KOX79675.1;KOX77898.1;KOX74186.1;KOX72201.1;KOX70861.1;KOX71579.1;KOX68054.1;KOX79817.1;KOX69619.1;KOX77364.1;KOX78841.1;KOX81246.1;KOX76214.1;KOX74477.1;KOX68647.1;KOX78509.1;KOX68084.1;KOX68654.1;KOX73800.1;KOX73724.1;KOX79522.1;KOX78362.1;KOX71595.1;KOX73362.1;KOX79166.1;KOX70561.1;KOX77803.1;KOX68566.1;KOX79039.1;KOX77506.1;KOX79033.1;KOX74479.1;KOX68521.1 Reactome: R-HSA-5357905 Regulation of TNFR1 signaling 8 KOX73463.1;KOX79430.1;KOX72105.1;KOX78046.1;KOX72543.1;KOX79433.1;KOX79902.1;KOX67229.1 MetaCyc: PWY-5394 Betalamic acid biosynthesis 1 KOX71846.1 Reactome: R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 33 KOX73976.1;KOX73997.1;KOX74577.1;KOX79433.1;KOX69335.1;KOX78385.1;KOX73246.1;KOX68797.1;KOX67229.1;KOX76831.1;KOX81204.1;KOX79430.1;KOX76332.1;KOX69259.1;KOX67192.1;KOX72917.1;KOX74184.1;KOX67522.1;KOX73512.1;KOX76387.1;KOX72015.1;KOX67917.1;KOX80996.1;KOX77118.1;KOX70663.1;KOX73551.1;KOX68248.1;KOX72406.1;KOX69299.1;KOX67875.1;KOX72105.1;KOX71483.1;KOX72890.1 Reactome: R-HSA-3878781 Glycogen storage disease type IV (GBE1) 1 KOX68382.1 MetaCyc: PWY-5046 2-oxoisovalerate decarboxylation to isobutanoyl-CoA 2 KOX75285.1;KOX75086.1 KEGG: 00640+4.2.1.17 Propanoate metabolism 2 KOX75101.1;KOX76405.1 KEGG: 00564+4.1.1.65 Glycerophospholipid metabolism 1 KOX70005.1 MetaCyc: PWY-2161B Glutamate removal from folates 1 KOX80762.1 Reactome: R-HSA-83936 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 5 KOX73132.1;KOX72970.1;KOX78523.1;KOX73546.1;KOX79571.1 KEGG: 00480+2.5.1.18+1.8.5.1 Glutathione metabolism 2 KOX69433.1;KOX71878.1 MetaCyc: PWY-6313 Serotonin degradation 1 KOX67600.1 MetaCyc: PWY-6549 L-glutamine biosynthesis III 2 KOX79046.1;KOX75490.1 Reactome: R-HSA-70263 Gluconeogenesis 13 KOX76362.1;KOX68597.1;KOX72508.1;KOX68814.1;KOX69541.1;KOX76361.1;KOX67203.1;KOX81104.1;KOX72507.1;KOX67919.1;KOX67171.1;KOX68340.1;KOX75374.1 MetaCyc: PWY-7094 Fatty acid salvage 2 KOX75101.1;KOX76405.1 MetaCyc: PWY-7182 Linalool biosynthesis I 1 KOX72808.1 MetaCyc: PWY-7159 3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent) 2 KOX69203.1;KOX75988.1 MetaCyc: PWY-5461 Betanidin degradation 2 KOX69438.1;KOX77231.1 KEGG: 00730+3.6.1.15 Thiamine metabolism 1 KOX74853.1 KEGG: 00310+1.8.1.4 Lysine degradation 1 KOX75086.1 Reactome: R-HSA-400511 Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) 6 KOX76114.1;KOX77642.1;KOX67929.1;KOX77641.1;KOX74243.1;KOX77868.1 Reactome: R-HSA-68884 Mitotic Telophase/Cytokinesis 1 KOX73197.1 MetaCyc: PWY-6587 Pyruvate fermentation to ethanol III 1 KOX67600.1 Reactome: R-HSA-3232142 SUMOylation of ubiquitinylation proteins 20 KOX72429.1;KOX75539.1;KOX75630.1;KOX80793.1;KOX79436.1;KOX68732.1;KOX73226.1;KOX80341.1;KOX78183.1;KOX72473.1;KOX69061.1;KOX77505.1;KOX73664.1;KOX73131.1;KOX77058.1;KOX75540.1;KOX79242.1;KOX68874.1;KOX75811.1;KOX81376.1 MetaCyc: PWY-7224 Purine deoxyribonucleosides salvage 4 KOX78412.1;KOX71458.1;KOX78158.1;KOX76865.1 KEGG: 00500+3.2.1.28 Starch and sucrose metabolism 3 KOX71539.1;KOX74001.1;KOX74002.1 MetaCyc: PWY-6969 TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase) 13 KOX75374.1;KOX79460.1;KOX79891.1;KOX74316.1;KOX68928.1;KOX70050.1;KOX79046.1;KOX77859.1;KOX79892.1;KOX68680.1;KOX79955.1;KOX70049.1;KOX69541.1 Reactome: R-HSA-75876 Synthesis of very long-chain fatty acyl-CoAs 21 KOX78662.1;KOX78657.1;KOX79701.1;KOX78650.1;KOX67486.1;KOX68696.1;KOX67350.1;KOX78654.1;KOX77795.1;KOX78660.1;KOX78651.1;KOX75202.1;KOX78659.1;KOX80068.1;KOX78713.1;KOX68279.1;KOX73201.1;KOX78236.1;KOX74597.1;KOX78653.1;KOX68278.1 KEGG: 00640+1.1.1.27 Propanoate metabolism 2 KOX77687.1;KOX77688.1 Reactome: R-HSA-8949664 Processing of SMDT1 12 KOX69397.1;KOX74583.1;KOX75281.1;KOX80750.1;KOX79546.1;KOX67701.1;KOX69336.1;KOX74585.1;KOX77636.1;KOX72018.1;KOX75686.1;KOX78018.1 KEGG: 00531+3.2.1.23 Glycosaminoglycan degradation 3 KOX77035.1;KOX75741.1;KOX80383.1 KEGG: 00010+4.2.1.11 Glycolysis / Gluconeogenesis 2 KOX81104.1;KOX71859.1 MetaCyc: PWY-2221 Entner-Doudoroff pathway III (semi-phosphorylative) 5 KOX74974.1;KOX69067.1;KOX81104.1;KOX74975.1;KOX71859.1 MetaCyc: PWY-6857 Retinol biosynthesis 1 KOX67326.1 KEGG: 00240+2.7.4.6 Pyrimidine metabolism 4 KOX78158.1;KOX76865.1;KOX78412.1;KOX71458.1 Reactome: R-HSA-5685942 HDR through Homologous Recombination (HRR) 35 KOX80977.1;KOX77830.1;KOX78024.1;KOX74923.1;KOX74812.1;KOX78861.1;KOX81364.1;KOX79433.1;KOX77356.1;KOX71452.1;KOX71763.1;KOX68054.1;KOX79430.1;KOX71786.1;KOX79196.1;KOX77923.1;KOX67229.1;KOX70673.1;KOX67721.1;KOX79548.1;KOX76598.1;KOX73599.1;KOX69173.1;KOX72024.1;KOX68669.1;KOX71969.1;KOX68858.1;KOX72105.1;KOX67310.1;KOX77326.1;KOX77276.1;KOX70402.1;KOX68243.1;KOX73285.1;KOX72417.1 Reactome: R-HSA-196819 Vitamin B1 (thiamin) metabolism 3 KOX78326.1;KOX76600.1;KOX74111.1 KEGG: 00010+1.1.1.1 Glycolysis / Gluconeogenesis 1 KOX67600.1 MetaCyc: PWY-6722 Candicidin biosynthesis 2 KOX79144.1;KOX70011.1 KEGG: 00480+2.5.1.18 Glutathione metabolism 1 KOX71611.1 MetaCyc: PWY-7841 Neolacto-series glycosphingolipids biosynthesis 1 KOX74918.1 MetaCyc: PWY-7886 Cell-surface glycoconjugate-linked phosphocholine biosynthesis 1 KOX67207.1 KEGG: 00520+2.7.1.1 Amino sugar and nucleotide sugar metabolism 2 KOX72065.1;KOX80688.1 KEGG: 00511+3.2.1.23 Other glycan degradation 3 KOX77035.1;KOX75741.1;KOX80383.1 Reactome: R-HSA-3108214 SUMOylation of DNA damage response and repair proteins 36 KOX67692.1;KOX81376.1;KOX75811.1;KOX73131.1;KOX71648.1;KOX77505.1;KOX73664.1;KOX77869.1;KOX80070.1;KOX71763.1;KOX80341.1;KOX68732.1;KOX71688.1;KOX75509.1;KOX77633.1;KOX78183.1;KOX75630.1;KOX80793.1;KOX79242.1;KOX68874.1;KOX74954.1;KOX69597.1;KOX75540.1;KOX69173.1;KOX74010.1;KOX77058.1;KOX73447.1;KOX79537.1;KOX72473.1;KOX69061.1;KOX73226.1;KOX70402.1;KOX79436.1;KOX72429.1;KOX75935.1;KOX75539.1 KEGG: 00670+2.1.2.2 One carbon pool by folate 1 KOX79954.1 Reactome: R-HSA-5603037 IRAK4 deficiency (TLR5) 1 KOX68497.1 MetaCyc: PWY-7347 Sucrose biosynthesis III 1 KOX67919.1 KEGG: 00010+2.7.1.40 Glycolysis / Gluconeogenesis 2 KOX74975.1;KOX74974.1 Reactome: R-HSA-1296061 HCN channels 1 KOX78560.1 KEGG: 04658+3.1.3.16 Th1 and Th2 cell differentiation 30 KOX81157.1;KOX74437.1;KOX75570.1;KOX71123.1;KOX74359.1;KOX73821.1;KOX72905.1;KOX67474.1;KOX69134.1;KOX79996.1;KOX78718.1;KOX71507.1;KOX73439.1;KOX76691.1;KOX75891.1;KOX71725.1;KOX80916.1;KOX70730.1;KOX78816.1;KOX68255.1;KOX74854.1;KOX68760.1;KOX68258.1;KOX74165.1;KOX68259.1;KOX71414.1;KOX72941.1;KOX69703.1;KOX72757.1;KOX78476.1 Reactome: R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry 8 KOX70592.1;KOX80899.1;KOX68519.1;KOX74615.1;KOX81403.1;KOX72538.1;KOX73662.1;KOX72400.1 KEGG: 00750+2.7.1.35 Vitamin B6 metabolism 1 KOX67899.1 KEGG: 00983+2.5.1.18 Drug metabolism - other enzymes 3 KOX71611.1;KOX71878.1;KOX69433.1 Reactome: R-HSA-77108 Utilization of Ketone Bodies 1 KOX75573.1 KEGG: 00230+2.4.2.7 Purine metabolism 1 KOX74349.1 Reactome: R-HSA-69541 Stabilization of p53 5 KOX67229.1;KOX68054.1;KOX79430.1;KOX79433.1;KOX72105.1 KEGG: 00720+6.2.1.5 Carbon fixation pathways in prokaryotes 4 KOX74316.1;KOX79892.1;KOX79891.1;KOX79460.1 Reactome: R-HSA-9665244 Resistance of ERBB2 KD mutants to sapitinib 1 KOX73791.1 Reactome: R-HSA-8854214 TBC/RABGAPs 6 KOX79055.1;KOX80745.1;KOX79937.1;KOX69422.1;KOX78812.1;KOX80332.1 Reactome: R-HSA-112126 ALKBH3 mediated reversal of alkylation damage 2 KOX79647.1;KOX67367.1 Reactome: R-HSA-70221 Glycogen breakdown (glycogenolysis) 4 KOX80377.1;KOX74487.1;KOX80326.1;KOX71658.1 Reactome: R-HSA-186797 Signaling by PDGF 3 KOX75492.1;KOX75720.1;KOX75715.1 Reactome: R-HSA-6799198 Complex I biogenesis 38 KOX67705.1;KOX80989.1;KOX81074.1;KOX75544.1;KOX78655.1;KOX68793.1;KOX75732.1;KOX67192.1;KOX75291.1;KOX73350.1;KOX78629.1;KOX69501.1;KOX73143.1;KOX68532.1;KOX69714.1;KOX69215.1;KOX79795.1;KOX72664.1;KOX79416.1;KOX81326.1;KOX77397.1;KOX72006.1;KOX75846.1;KOX79816.1;KOX72809.1;KOX78801.1;KOX67427.1;KOX81235.1;KOX70714.1;KOX68416.1;KOX71021.1;KOX68433.1;KOX67584.1;KOX74914.1;KOX73142.1;KOX68112.1;KOX79348.1;KOX79413.1 MetaCyc: PWY-6368 3-phosphoinositide degradation 5 KOX78048.1;KOX78498.1;KOX71993.1;KOX74178.1;KOX75106.1 Reactome: R-HSA-480985 Synthesis of dolichyl-phosphate-glucose 1 KOX70949.1 Reactome: R-HSA-3000480 Scavenging by Class A Receptors 5 KOX69335.1;KOX73976.1;KOX80996.1;KOX73997.1;KOX68248.1 KEGG: 00250+6.3.4.5 Alanine, aspartate and glutamate metabolism 1 KOX69117.1 MetaCyc: PWY-6608 Guanosine nucleotides degradation III 5 KOX71781.1;KOX75972.1;KOX75971.1;KOX78203.1;KOX73844.1 Reactome: R-HSA-9627069 Regulation of the apoptosome activity 7 KOX69899.1;KOX68500.1;KOX73754.1;KOX78094.1;KOX69910.1;KOX74588.1;KOX78217.1 MetaCyc: PWY-381 Nitrate reduction II (assimilatory) 1 KOX75490.1 KEGG: 00230+4.3.2.2 Purine metabolism 1 KOX71530.1 KEGG: 00720+6.4.1.2 Carbon fixation pathways in prokaryotes 1 KOX70011.1 Reactome: R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 95 KOX72074.1;KOX73308.1;KOX75958.1;KOX67807.1;KOX67810.1;KOX71471.1;KOX70724.1;KOX78800.1;KOX67795.1;KOX71394.1;KOX77188.1;KOX70176.1;KOX67699.1;KOX69831.1;KOX70570.1;KOX67229.1;KOX71403.1;KOX75143.1;KOX81212.1;KOX67935.1;KOX79430.1;KOX70147.1;KOX67698.1;KOX69171.1;KOX80902.1;KOX72330.1;KOX79611.1;KOX75358.1;KOX70874.1;KOX68107.1;KOX68744.1;KOX78670.1;KOX68042.1;KOX74804.1;KOX78289.1;KOX73450.1;KOX73889.1;KOX75967.1;KOX67227.1;KOX67969.1;KOX70175.1;KOX73120.1;KOX78826.1;KOX79433.1;KOX79738.1;KOX76900.1;KOX78568.1;KOX70024.1;KOX72904.1;KOX70051.1;KOX67237.1;KOX75432.1;KOX80758.1;KOX69593.1;KOX75945.1;KOX72125.1;KOX67361.1;KOX73344.1;KOX79160.1;KOX80864.1;KOX77016.1;KOX71651.1;KOX75227.1;KOX75483.1;KOX72185.1;KOX71077.1;KOX76065.1;KOX70174.1;KOX75024.1;KOX74357.1;KOX75797.1;KOX81215.1;KOX72660.1;KOX78350.1;KOX68431.1;KOX71988.1;KOX75064.1;KOX74637.1;KOX77911.1;KOX74170.1;KOX79914.1;KOX77634.1;KOX70202.1;KOX68213.1;KOX69807.1;KOX74407.1;KOX81388.1;KOX79833.1;KOX77134.1;KOX72105.1;KOX73982.1;KOX72644.1;KOX72470.1;KOX74668.1;KOX67280.1 Reactome: R-HSA-5632928 Defective Mismatch Repair Associated With MSH2 2 KOX70744.1;KOX68230.1 KEGG: 00620+2.3.1.12 Pyruvate metabolism 1 KOX79834.1 Reactome: R-HSA-69473 G2/M DNA damage checkpoint 30 KOX73599.1;KOX73670.1;KOX74812.1;KOX69173.1;KOX74923.1;KOX72024.1;KOX74214.1;KOX80977.1;KOX67692.1;KOX79548.1;KOX68669.1;KOX79522.1;KOX74217.1;KOX71452.1;KOX72221.1;KOX68522.1;KOX79065.1;KOX71424.1;KOX79196.1;KOX70402.1;KOX68243.1;KOX71763.1;KOX80991.1;KOX68054.1;KOX71786.1;KOX79987.1;KOX72417.1;KOX77330.1;KOX73285.1;KOX68199.1 Reactome: R-HSA-418890 Role of second messengers in netrin-1 signaling 7 KOX75314.1;KOX71097.1;KOX75310.1;KOX70909.1;KOX75313.1;KOX80705.1;KOX80578.1 Reactome: R-HSA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 40 KOX72468.1;KOX78268.1;KOX71606.1;KOX80582.1;KOX75984.1;KOX74910.1;KOX79433.1;KOX69688.1;KOX74924.1;KOX74011.1;KOX73209.1;KOX79430.1;KOX78266.1;KOX76879.1;KOX68314.1;KOX72411.1;KOX70598.1;KOX76009.1;KOX70009.1;KOX67229.1;KOX76416.1;KOX73060.1;KOX79626.1;KOX80008.1;KOX70760.1;KOX75968.1;KOX68748.1;KOX69333.1;KOX78273.1;KOX69414.1;KOX79601.1;KOX70419.1;KOX72105.1;KOX79230.1;KOX79363.1;KOX77271.1;KOX72982.1;KOX78786.1;KOX68313.1;KOX70383.1 KEGG: 00190+7.1.1.8 Oxidative phosphorylation 1 KOX76195.1 Reactome: R-HSA-381753 Olfactory Signaling Pathway 2 KOX76075.1;KOX77529.1 Reactome: R-HSA-420092 Glucagon-type ligand receptors 5 KOX69081.1;KOX79656.1;KOX78343.1;KOX79467.1;KOX76508.1 Reactome: R-HSA-1483226 Synthesis of PI 1 KOX76348.1 KEGG: 00625+1.1.1.1 Chloroalkane and chloroalkene degradation 1 KOX67600.1 Reactome: R-HSA-70350 Fructose catabolism 6 KOX77329.1;KOX77358.1;KOX80312.1;KOX80313.1;KOX79350.1;KOX75433.1 MetaCyc: PWY-7589 Palmitoleate biosynthesis III (cyanobacteria) 4 KOX67923.1;KOX79114.1;KOX75990.1;KOX77858.1 Reactome: R-HSA-416476 G alpha (q) signalling events 18 KOX70895.1;KOX76508.1;KOX71113.1;KOX79656.1;KOX71639.1;KOX69287.1;KOX78343.1;KOX70804.1;KOX70346.1;KOX81045.1;KOX70896.1;KOX74728.1;KOX69081.1;KOX75330.1;KOX79467.1;KOX75256.1;KOX67567.1;KOX78636.1 KEGG: 00860+4.99.1.1 Porphyrin and chlorophyll metabolism 1 KOX80939.1 Reactome: R-HSA-2453864 Retinoid cycle disease events 1 KOX78431.1 KEGG: 00930+4.2.1.17+1.1.1.35 Caprolactam degradation 2 KOX75101.1;KOX76405.1 MetaCyc: PWY-5743 3-hydroxypropanoate cycle 5 KOX80775.1;KOX70011.1;KOX79144.1;KOX68087.1;KOX68932.1 KEGG: 00983+2.4.2.3 Drug metabolism - other enzymes 1 KOX77619.1 KEGG: 00730+3.1.3.2 Thiamine metabolism 9 KOX69530.1;KOX80576.1;KOX80574.1;KOX73842.1;KOX80575.1;KOX79542.1;KOX74329.1;KOX75677.1;KOX73843.1 KEGG: 00983+1.17.4.1 Drug metabolism - other enzymes 1 KOX79885.1 MetaCyc: PWY-8051 Anandamide biosynthesis I 18 KOX78399.1;KOX76514.1;KOX79218.1;KOX78316.1;KOX80284.1;KOX75783.1;KOX75990.1;KOX78275.1;KOX69576.1;KOX79114.1;KOX72448.1;KOX67863.1;KOX67923.1;KOX69497.1;KOX77858.1;KOX80280.1;KOX70330.1;KOX77917.1 Reactome: R-HSA-111931 PKA-mediated phosphorylation of CREB 1 KOX74139.1 KEGG: 00290+2.6.1.42 Valine, leucine and isoleucine biosynthesis 1 KOX72274.1 MetaCyc: PWY-6142 Gluconeogenesis II (Methanobacterium thermoautotrophicum) 12 KOX68932.1;KOX81104.1;KOX68087.1;KOX74974.1;KOX76361.1;KOX76362.1;KOX68340.1;KOX71859.1;KOX74975.1;KOX80775.1;KOX67171.1;KOX67919.1 Reactome: R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 13 KOX79878.1;KOX79369.1;KOX67554.1;KOX75836.1;KOX72976.1;KOX76245.1;KOX73883.1;KOX76246.1;KOX73452.1;KOX79051.1;KOX75547.1;KOX68690.1;KOX73878.1 Reactome: R-HSA-73614 Pyrimidine salvage 3 KOX78077.1;KOX77619.1;KOX79373.1 Reactome: R-HSA-1222556 ROS and RNS production in phagocytes 14 KOX72760.1;KOX69852.1;KOX77098.1;KOX72144.1;KOX75459.1;KOX68681.1;KOX71792.1;KOX78327.1;KOX79728.1;KOX73541.1;KOX76903.1;KOX70575.1;KOX75953.1;KOX74155.1 Reactome: R-HSA-918233 TRAF3-dependent IRF activation pathway 2 KOX69665.1;KOX70261.1 Reactome: R-HSA-8849471 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 1 KOX69748.1 Reactome: R-HSA-6806664 Metabolism of vitamin K 2 KOX79029.1;KOX79863.1 MetaCyc: PWY-6535 4-aminobutanoate degradation I 1 KOX75380.1 Reactome: R-HSA-202733 Cell surface interactions at the vascular wall 9 KOX73118.1;KOX68248.1;KOX73997.1;KOX80996.1;KOX70849.1;KOX73976.1;KOX72907.1;KOX68045.1;KOX69335.1 Reactome: R-HSA-209931 Serotonin and melatonin biosynthesis 1 KOX81148.1 MetaCyc: PWY-6557 Glycosaminoglycan-protein linkage region biosynthesis 1 KOX79480.1 Reactome: R-HSA-168164 Toll Like Receptor 3 (TLR3) Cascade 1 KOX68495.1 Reactome: R-HSA-6791461 RPIA deficiency: failed conversion of RU5P to R5P 1 KOX80223.1 Reactome: R-HSA-389661 Glyoxylate metabolism and glycine degradation 23 KOX76243.1;KOX78471.1;KOX70042.1;KOX81081.1;KOX75086.1;KOX68433.1;KOX70384.1;KOX74119.1;KOX75142.1;KOX67769.1;KOX78238.1;KOX75285.1;KOX72271.1;KOX76981.1;KOX69757.1;KOX72452.1;KOX80585.1;KOX71375.1;KOX67894.1;KOX69370.1;KOX79834.1;KOX75475.1;KOX81337.1 MetaCyc: PWY-7385 1,3-propanediol biosynthesis (engineered) 6 KOX67919.1;KOX76362.1;KOX75460.1;KOX76361.1;KOX67867.1;KOX75465.1 Reactome: R-HSA-5666185 RHO GTPases Activate Rhotekin and Rhophilins 1 KOX68635.1 MetaCyc: PWY-8052 2-arachidonoylglycerol biosynthesis 6 KOX74989.1;KOX71582.1;KOX75330.1;KOX80284.1;KOX74728.1;KOX67863.1 Reactome: R-HSA-2500257 Resolution of Sister Chromatid Cohesion 50 KOX72162.1;KOX70129.1;KOX69879.1;KOX78693.1;KOX78195.1;KOX77058.1;KOX79744.1;KOX76545.1;KOX72302.1;KOX68210.1;KOX71037.1;KOX79242.1;KOX71089.1;KOX75272.1;KOX79174.1;KOX81328.1;KOX74954.1;KOX72164.1;KOX77793.1;KOX68498.1;KOX76312.1;KOX72473.1;KOX72163.1;KOX72161.1;KOX69061.1;KOX79039.1;KOX80503.1;KOX77505.1;KOX72895.1;KOX77869.1;KOX70729.1;KOX78000.1;KOX69536.1;KOX75211.1;KOX73340.1;KOX74302.1;KOX75516.1;KOX70177.1;KOX74202.1;KOX72068.1;KOX80793.1;KOX75601.1;KOX81286.1;KOX68732.1;KOX72021.1;KOX69417.1;KOX68198.1;KOX72843.1;KOX68193.1;KOX76379.1 Reactome: R-HSA-3000484 Scavenging by Class F Receptors 5 KOX69335.1;KOX73976.1;KOX80996.1;KOX73997.1;KOX68248.1 Reactome: R-HSA-70635 Urea cycle 2 KOX81392.1;KOX69117.1 Reactome: R-HSA-383280 Nuclear Receptor transcription pathway 30 KOX75656.1;KOX75140.1;KOX78063.1;KOX73461.1;KOX69052.1;KOX69133.1;KOX78053.1;KOX72720.1;KOX78864.1;KOX68963.1;KOX67846.1;KOX69371.1;KOX67337.1;KOX69256.1;KOX67983.1;KOX67849.1;KOX76694.1;KOX72721.1;KOX75042.1;KOX74387.1;KOX80497.1;KOX72301.1;KOX73224.1;KOX78061.1;KOX70525.1;KOX77809.1;KOX76693.1;KOX73801.1;KOX79003.1;KOX77812.1 Reactome: R-HSA-425561 Sodium/Calcium exchangers 9 KOX71031.1;KOX76189.1;KOX71026.1;KOX70134.1;KOX74223.1;KOX74224.1;KOX76187.1;KOX71030.1;KOX75012.1 Reactome: R-HSA-8963684 Tyrosine catabolism 5 KOX69218.1;KOX75714.1;KOX80034.1;KOX71039.1;KOX80035.1 Reactome: R-HSA-165158 Activation of AKT2 1 KOX78362.1 Reactome: R-HSA-804914 Transport of fatty acids 1 KOX72645.1 KEGG: 00020+1.3.5.1 Citrate cycle (TCA cycle) 2 KOX79955.1;KOX68680.1 Reactome: R-HSA-189085 Digestion of dietary carbohydrate 42 KOX79151.1;KOX71539.1;KOX80013.1;KOX70625.1;KOX79146.1;KOX75203.1;KOX76147.1;KOX80018.1;KOX71484.1;KOX75564.1;KOX77106.1;KOX78999.1;KOX68131.1;KOX73522.1;KOX81049.1;KOX70686.1;KOX76156.1;KOX80014.1;KOX72270.1;KOX71808.1;KOX69318.1;KOX79325.1;KOX79324.1;KOX77893.1;KOX74001.1;KOX79703.1;KOX80909.1;KOX67792.1;KOX79966.1;KOX71811.1;KOX75878.1;KOX73406.1;KOX79466.1;KOX71774.1;KOX68989.1;KOX76148.1;KOX79150.1;KOX74002.1;KOX80017.1;KOX79309.1;KOX73145.1;KOX76151.1 Reactome: R-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 5 KOX70373.1;KOX77394.1;KOX74217.1;KOX77330.1;KOX74214.1 Reactome: R-HSA-110312 Translesion synthesis by REV1 16 KOX72105.1;KOX79430.1;KOX70402.1;KOX67310.1;KOX73285.1;KOX80464.1;KOX72417.1;KOX70673.1;KOX67229.1;KOX79548.1;KOX74923.1;KOX78024.1;KOX79433.1;KOX71969.1;KOX76509.1;KOX71452.1 KEGG: 00270+1.1.1.27 Cysteine and methionine metabolism 2 KOX77687.1;KOX77688.1 Reactome: R-HSA-174362 Transport and synthesis of PAPS 2 KOX68057.1;KOX74601.1 Reactome: R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat 33 KOX79649.1;KOX74909.1;KOX71506.1;KOX73785.1;KOX77062.1;KOX74908.1;KOX77418.1;KOX67200.1;KOX72082.1;KOX74030.1;KOX78553.1;KOX67799.1;KOX81203.1;KOX69719.1;KOX74919.1;KOX69424.1;KOX72538.1;KOX75987.1;KOX80159.1;KOX74806.1;KOX81403.1;KOX69897.1;KOX74945.1;KOX81395.1;KOX69540.1;KOX70044.1;KOX77626.1;KOX78696.1;KOX67622.1;KOX73198.1;KOX68573.1;KOX70730.1;KOX77063.1 MetaCyc: PWY-561 Superpathway of glyoxylate cycle and fatty acid degradation 8 KOX77859.1;KOX68680.1;KOX79955.1;KOX70049.1;KOX69541.1;KOX75374.1;KOX68928.1;KOX70050.1 KEGG: 00010+5.4.2.11 Glycolysis / Gluconeogenesis 1 KOX73085.1 MetaCyc: PWY-66 GDP-L-fucose biosynthesis I (from GDP-D-mannose) 1 KOX69413.1 MetaCyc: PWY-5083 NAD/NADH phosphorylation and dephosphorylation 1 KOX79573.1 Reactome: R-HSA-373753 Nephrin family interactions 3 KOX79326.1;KOX79382.1;KOX71656.1 MetaCyc: PWY-735 Jasmonic acid biosynthesis 2 KOX73119.1;KOX71616.1 KEGG: 00240+2.4.2.3 Pyrimidine metabolism 1 KOX77619.1 Reactome: R-HSA-1839117 Signaling by cytosolic FGFR1 fusion mutants 2 KOX68654.1;KOX81204.1 KEGG: 00564+3.1.4.4 Glycerophospholipid metabolism 1 KOX74104.1 Reactome: R-HSA-2559580 Oxidative Stress Induced Senescence 18 KOX67229.1;KOX77330.1;KOX70201.1;KOX74484.1;KOX80899.1;KOX72105.1;KOX68069.1;KOX79430.1;KOX74217.1;KOX68500.1;KOX79433.1;KOX80039.1;KOX73880.1;KOX74214.1;KOX74580.1;KOX73800.1;KOX73517.1;KOX68690.1 KEGG: 00590+3.1.1.4 Arachidonic acid metabolism 10 KOX69497.1;KOX78399.1;KOX79218.1;KOX78316.1;KOX75783.1;KOX78275.1;KOX69576.1;KOX72448.1;KOX70330.1;KOX77917.1 Reactome: R-HSA-382556 ABC-family proteins mediated transport 46 KOX80582.1;KOX71606.1;KOX72468.1;KOX78268.1;KOX73209.1;KOX72942.1;KOX74011.1;KOX79433.1;KOX74924.1;KOX75984.1;KOX74910.1;KOX70598.1;KOX72411.1;KOX68314.1;KOX79430.1;KOX78266.1;KOX76879.1;KOX67229.1;KOX76416.1;KOX73060.1;KOX76009.1;KOX70009.1;KOX75968.1;KOX70760.1;KOX80008.1;KOX79626.1;KOX69414.1;KOX78273.1;KOX75337.1;KOX68748.1;KOX69333.1;KOX68043.1;KOX70174.1;KOX70175.1;KOX79230.1;KOX70419.1;KOX72105.1;KOX72913.1;KOX79601.1;KOX70383.1;KOX78786.1;KOX68313.1;KOX72982.1;KOX77271.1;KOX79363.1;KOX68195.1 KEGG: 00563+2.4.1.198 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 3 KOX72990.1;KOX72430.1;KOX69083.1 Reactome: R-HSA-204174 Regulation of pyruvate dehydrogenase (PDH) complex 8 KOX71039.1;KOX75086.1;KOX79834.1;KOX74119.1;KOX78471.1;KOX76243.1;KOX70042.1;KOX80546.1 Reactome: R-HSA-8847993 ERBB2 Activates PTK6 Signaling 1 KOX72629.1 MetaCyc: PWY-6644 Fluoroacetate and fluorothreonine biosynthesis 1 KOX78203.1 Reactome: R-HSA-5609977 Defective GALE can cause Epimerase-deficiency galactosemia (EDG) 2 KOX72084.1;KOX77926.1 KEGG: 00052+2.7.1.1 Galactose metabolism 2 KOX72065.1;KOX80688.1 MetaCyc: PWY-7221 Guanosine ribonucleotides de novo biosynthesis 12 KOX78850.1;KOX78842.1;KOX72404.1;KOX78444.1;KOX73158.1;KOX76865.1;KOX78412.1;KOX71458.1;KOX78158.1;KOX80463.1;KOX70499.1;KOX72712.1 KEGG: 00970+6.3.5.7 Aminoacyl-tRNA biosynthesis 4 KOX74867.1;KOX70038.1;KOX67811.1;KOX68618.1 Reactome: R-HSA-204005 COPII-mediated vesicle transport 22 KOX67706.1;KOX77980.1;KOX70722.1;KOX79123.1;KOX74595.1;KOX74767.1;KOX70924.1;KOX72450.1;KOX80373.1;KOX72665.1;KOX69869.1;KOX74480.1;KOX79785.1;KOX77666.1;KOX70581.1;KOX67228.1;KOX71890.1;KOX74490.1;KOX79124.1;KOX77058.1;KOX80449.1;KOX73349.1 Reactome: R-HSA-456926 Thrombin signalling through proteinase activated receptors (PARs) 8 KOX76508.1;KOX79656.1;KOX69081.1;KOX71441.1;KOX79467.1;KOX68500.1;KOX78343.1;KOX67567.1 Reactome: R-HSA-9637628 Modulation by Mtb of host immune system 4 KOX79433.1;KOX79430.1;KOX72105.1;KOX67229.1 MetaCyc: PWY-5138 Fatty acid beta-oxidation IV (unsaturated, even number) 2 KOX76405.1;KOX75101.1 KEGG: 00240+6.3.5.5 Pyrimidine metabolism 1 KOX80440.1 Reactome: R-HSA-77288 mitochondrial fatty acid beta-oxidation of unsaturated fatty acids 1 KOX76405.1 Reactome: R-HSA-9018519 Estrogen-dependent gene expression 31 KOX70044.1;KOX77626.1;KOX75722.1;KOX67200.1;KOX77418.1;KOX77063.1;KOX77330.1;KOX79878.1;KOX70201.1;KOX74484.1;KOX69665.1;KOX73198.1;KOX75721.1;KOX67799.1;KOX81203.1;KOX74812.1;KOX74214.1;KOX76543.1;KOX74580.1;KOX73517.1;KOX74954.1;KOX79649.1;KOX67889.1;KOX68332.1;KOX74904.1;KOX74217.1;KOX77869.1;KOX68963.1;KOX77062.1;KOX80598.1;KOX74806.1 Reactome: R-HSA-204626 Hypusine synthesis from eIF5A-lysine 2 KOX77509.1;KOX76699.1 MetaCyc: PWY-6372 1D-myo-inositol hexakisphosphate biosynthesis IV (Dictyostelium) 3 KOX81095.1;KOX81098.1;KOX68055.1 MetaCyc: PWY-7184 Pyrimidine deoxyribonucleotides de novo biosynthesis I 10 KOX76865.1;KOX74853.1;KOX80826.1;KOX71982.1;KOX78158.1;KOX79885.1;KOX71458.1;KOX79122.1;KOX78412.1;KOX69334.1 Reactome: R-HSA-209543 p75NTR recruits signalling complexes 6 KOX72105.1;KOX79430.1;KOX79433.1;KOX68497.1;KOX67229.1;KOX73643.1 Reactome: R-HSA-9630222 Defective NTHL1 substrate binding 1 KOX77492.1 Reactome: R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane 6 KOX71684.1;KOX71037.1;KOX75788.1;KOX69536.1;KOX76312.1;KOX73320.1 MetaCyc: PWY-6397 Mycolyl-arabinogalactan-peptidoglycan complex biosynthesis 2 KOX77926.1;KOX72084.1 Reactome: R-HSA-373080 Class B/2 (Secretin family receptors) 15 KOX71666.1;KOX74261.1;KOX80704.1;KOX73317.1;KOX80053.1;KOX68081.1;KOX76015.1;KOX77372.1;KOX78070.1;KOX74260.1;KOX68621.1;KOX77282.1;KOX77371.1;KOX74858.1;KOX76787.1 Reactome: R-HSA-77285 Beta oxidation of myristoyl-CoA to lauroyl-CoA 1 KOX76405.1 Reactome: R-HSA-1660517 Synthesis of PIPs at the late endosome membrane 3 KOX70260.1;KOX76722.1;KOX71993.1 Reactome: R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 20 KOX80341.1;KOX73226.1;KOX68732.1;KOX78183.1;KOX72473.1;KOX69061.1;KOX72429.1;KOX75539.1;KOX75630.1;KOX79436.1;KOX80793.1;KOX75540.1;KOX79242.1;KOX68874.1;KOX81376.1;KOX75811.1;KOX77505.1;KOX73664.1;KOX73131.1;KOX77058.1 MetaCyc: PWY-6019 Pseudouridine degradation 1 KOX78235.1 Reactome: R-HSA-9603798 Class I peroxisomal membrane protein import 11 KOX67202.1;KOX71980.1;KOX73333.1;KOX75952.1;KOX71981.1;KOX69300.1;KOX76001.1;KOX72029.1;KOX73332.1;KOX80827.1;KOX74021.1 KEGG: 00561+3.1.3.4 Glycerolipid metabolism 2 KOX67863.1;KOX80284.1 MetaCyc: PWY-6113 Superpathway of mycolate biosynthesis 2 KOX73549.1;KOX69550.1 Reactome: R-HSA-1483191 Synthesis of PC 9 KOX79335.1;KOX79369.1;KOX67207.1;KOX79704.1;KOX69985.1;KOX80407.1;KOX67863.1;KOX70692.1;KOX78075.1 Reactome: R-HSA-5607763 CLEC7A (Dectin-1) induces NFAT activation 1 KOX73812.1 Reactome: R-HSA-1433557 Signaling by SCF-KIT 3 KOX70804.1;KOX72190.1;KOX81204.1 KEGG: 04070+3.1.4.11 Phosphatidylinositol signaling system 4 KOX74728.1;KOX74989.1;KOX71582.1;KOX75330.1 KEGG: 00230+6.3.5.2 Purine metabolism 1 KOX80463.1 KEGG: 00330+1.2.1.88 Arginine and proline metabolism 1 KOX67769.1 KEGG: 00640+1.2.4.4 Propanoate metabolism 1 KOX75285.1 Reactome: R-HSA-975634 Retinoid metabolism and transport 13 KOX73976.1;KOX80363.1;KOX78316.1;KOX68248.1;KOX78399.1;KOX73118.1;KOX80996.1;KOX73997.1;KOX78431.1;KOX80364.1;KOX69335.1;KOX76492.1;KOX78275.1 MetaCyc: PWY-6863 Pyruvate fermentation to hexanol (engineered) 2 KOX75101.1;KOX76405.1 Reactome: R-HSA-8876493 InlA-mediated entry of Listeria monocytogenes into host cells 4 KOX67229.1;KOX72105.1;KOX79430.1;KOX79433.1 Reactome: R-HSA-111459 Activation of caspases through apoptosome-mediated cleavage 4 KOX73754.1;KOX69899.1;KOX69910.1;KOX78094.1 MetaCyc: PWY-6620 Guanine and guanosine salvage 1 KOX78203.1 Reactome: R-HSA-4720475 Defective ALG3 causes ALG3-CDG (CDG-1d) 1 KOX71269.1 KEGG: 00500+2.4.1.25 Starch and sucrose metabolism 1 KOX74487.1 MetaCyc: PWY-6134 L-tyrosine biosynthesis IV 1 KOX77562.1 Reactome: R-HSA-917977 Transferrin endocytosis and recycling 13 KOX75953.1;KOX74155.1;KOX71792.1;KOX76903.1;KOX70575.1;KOX79728.1;KOX78327.1;KOX73541.1;KOX77098.1;KOX69852.1;KOX75459.1;KOX72144.1;KOX72760.1 Reactome: R-HSA-5658442 Regulation of RAS by GAPs 43 KOX72411.1;KOX68314.1;KOX70598.1;KOX76879.1;KOX78266.1;KOX79430.1;KOX73060.1;KOX67229.1;KOX76416.1;KOX70009.1;KOX76009.1;KOX80582.1;KOX78268.1;KOX72468.1;KOX71606.1;KOX74011.1;KOX73209.1;KOX74910.1;KOX75984.1;KOX69128.1;KOX79433.1;KOX74924.1;KOX79230.1;KOX79601.1;KOX72105.1;KOX70419.1;KOX68313.1;KOX81100.1;KOX78786.1;KOX70383.1;KOX77271.1;KOX79363.1;KOX72982.1;KOX70760.1;KOX69748.1;KOX75968.1;KOX79626.1;KOX80008.1;KOX78273.1;KOX74032.1;KOX69414.1;KOX69333.1;KOX68748.1 Reactome: R-HSA-4755609 Defective DHDDS causes retinitis pigmentosa 59 2 KOX70726.1;KOX80579.1 Reactome: R-HSA-434316 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion 2 KOX67567.1;KOX75330.1 KEGG: 00562+2.7.1.137 Inositol phosphate metabolism 1 KOX76722.1 KEGG: 00564+3.1.3.27 Glycerophospholipid metabolism 1 KOX74437.1 Reactome: R-HSA-9034864 Activated NTRK3 signals through RAS 1 KOX81204.1 KEGG: 00520+5.4.2.8 Amino sugar and nucleotide sugar metabolism 1 KOX72772.1 Reactome: R-HSA-977443 GABA receptor activation 4 KOX67417.1;KOX68118.1;KOX80104.1;KOX68119.1 Reactome: R-HSA-3000471 Scavenging by Class B Receptors 6 KOX69335.1;KOX73976.1;KOX80996.1;KOX73997.1;KOX75036.1;KOX68248.1 Reactome: R-HSA-8943723 Regulation of PTEN mRNA translation 5 KOX68332.1;KOX67889.1;KOX74580.1;KOX74484.1;KOX70201.1 Reactome: R-HSA-5607764 CLEC7A (Dectin-1) signaling 43 KOX72411.1;KOX68314.1;KOX70598.1;KOX79430.1;KOX78266.1;KOX76879.1;KOX76416.1;KOX67229.1;KOX73060.1;KOX76009.1;KOX70009.1;KOX80582.1;KOX72468.1;KOX78268.1;KOX71606.1;KOX74011.1;KOX73209.1;KOX75984.1;KOX74910.1;KOX74924.1;KOX69688.1;KOX79433.1;KOX79230.1;KOX79601.1;KOX70419.1;KOX72105.1;KOX78786.1;KOX68313.1;KOX70383.1;KOX79363.1;KOX77271.1;KOX72982.1;KOX80285.1;KOX70760.1;KOX75968.1;KOX79626.1;KOX80008.1;KOX75998.1;KOX78362.1;KOX78273.1;KOX69414.1;KOX68748.1;KOX69333.1 Reactome: R-HSA-3656532 TGFBR1 KD Mutants in Cancer 1 KOX74896.1 KEGG: 00561+2.7.1.107 Glycerolipid metabolism 4 KOX79421.1;KOX68067.1;KOX76676.1;KOX73249.1 Reactome: R-HSA-77310 Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA 1 KOX76405.1 Reactome: R-HSA-195253 Degradation of beta-catenin by the destruction complex 46 KOX69333.1;KOX68748.1;KOX78273.1;KOX69414.1;KOX79626.1;KOX80008.1;KOX71037.1;KOX70760.1;KOX75968.1;KOX79363.1;KOX77271.1;KOX72982.1;KOX75788.1;KOX68313.1;KOX78786.1;KOX70383.1;KOX79601.1;KOX76312.1;KOX72105.1;KOX70419.1;KOX79230.1;KOX74910.1;KOX75984.1;KOX73320.1;KOX74924.1;KOX69536.1;KOX69688.1;KOX79433.1;KOX74011.1;KOX73209.1;KOX78268.1;KOX72468.1;KOX71606.1;KOX80582.1;KOX78521.1;KOX70009.1;KOX76009.1;KOX73060.1;KOX76416.1;KOX67229.1;KOX78266.1;KOX76879.1;KOX79430.1;KOX72411.1;KOX68314.1;KOX70598.1 Reactome: R-HSA-167172 Transcription of the HIV genome 29 KOX78263.1;KOX72538.1;KOX79649.1;KOX71363.1;KOX73785.1;KOX77907.1;KOX74806.1;KOX74930.1;KOX69085.1;KOX69897.1;KOX81403.1;KOX77062.1;KOX68559.1;KOX67200.1;KOX71842.1;KOX77418.1;KOX71518.1;KOX77626.1;KOX74030.1;KOX70044.1;KOX69540.1;KOX77334.1;KOX68729.1;KOX73198.1;KOX81203.1;KOX77063.1;KOX81398.1;KOX69719.1;KOX74919.1 MetaCyc: PWY-7857 Adlupulone and adhumulone biosynthesis 1 KOX74892.1 Reactome: R-HSA-373752 Netrin-1 signaling 1 KOX79525.1 KEGG: 00970+2.1.2.9 Aminoacyl-tRNA biosynthesis 3 KOX75639.1;KOX79954.1;KOX71788.1 Reactome: R-HSA-140342 Apoptosis induced DNA fragmentation 1 KOX78649.1 KEGG: 00592+4.2.1.17 alpha-Linolenic acid metabolism 2 KOX75101.1;KOX76405.1 MetaCyc: PWY-6749 CMP-legionaminate biosynthesis I 4 KOX68219.1;KOX74440.1;KOX70795.1;KOX79915.1 Reactome: R-HSA-163685 Integration of energy metabolism 1 KOX76312.1 MetaCyc: PWY-6938 NADH repair 2 KOX73799.1;KOX68200.1 KEGG: 00785+2.8.1.8 Lipoic acid metabolism 1 KOX75142.1 KEGG: 00310+2.3.1.61 Lysine degradation 1 KOX70384.1 Reactome: R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 32 KOX72068.1;KOX75601.1;KOX80793.1;KOX76379.1;KOX68732.1;KOX69417.1;KOX72021.1;KOX81286.1;KOX75211.1;KOX69536.1;KOX78000.1;KOX80503.1;KOX70729.1;KOX77505.1;KOX74202.1;KOX75516.1;KOX73340.1;KOX74302.1;KOX72473.1;KOX76312.1;KOX68498.1;KOX79039.1;KOX69061.1;KOX78693.1;KOX77058.1;KOX78195.1;KOX71037.1;KOX79242.1;KOX71089.1;KOX81328.1;KOX68210.1;KOX76545.1 Reactome: R-HSA-9029569 NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 8 KOX67889.1;KOX68332.1;KOX74580.1;KOX72645.1;KOX79246.1;KOX70201.1;KOX71059.1;KOX74484.1 MetaCyc: PWY-3341 L-proline biosynthesis III (from L-ornithine) 3 KOX79797.1;KOX79798.1;KOX70089.1 Reactome: R-HSA-8849932 Synaptic adhesion-like molecules 4 KOX80329.1;KOX78706.1;KOX69406.1;KOX68537.1 Reactome: R-HSA-5632927 Defective Mismatch Repair Associated With MSH3 1 KOX70744.1 Reactome: R-HSA-5655253 Signaling by FGFR2 in disease 1 KOX81204.1 MetaCyc: PWY-6363 D-myo-inositol (1,4,5)-trisphosphate degradation 4 KOX75546.1;KOX75545.1;KOX69866.1;KOX71857.1 KEGG: 00512+2.4.1.122 Mucin type O-glycan biosynthesis 1 KOX71619.1 Reactome: R-HSA-2173789 TGF-beta receptor signaling activates SMADs 1 KOX74896.1 MetaCyc: PWY-6309 L-tryptophan degradation XI (mammalian, via kynurenine) 1 KOX80071.1 Reactome: R-HSA-389960 Formation of tubulin folding intermediates by CCT/TriC 15 KOX75272.1;KOX69322.1;KOX69602.1;KOX76721.1;KOX79744.1;KOX72302.1;KOX77793.1;KOX68198.1;KOX76688.1;KOX81218.1;KOX72843.1;KOX76507.1;KOX78324.1;KOX69879.1;KOX67167.1 Reactome: R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 49 KOX75984.1;KOX72749.1;KOX74910.1;KOX74924.1;KOX79433.1;KOX74011.1;KOX73209.1;KOX72468.1;KOX78268.1;KOX79389.1;KOX71606.1;KOX80582.1;KOX71992.1;KOX76009.1;KOX70009.1;KOX76416.1;KOX67229.1;KOX73060.1;KOX76684.1;KOX79430.1;KOX78266.1;KOX76879.1;KOX72154.1;KOX68314.1;KOX72411.1;KOX70598.1;KOX74256.1;KOX68748.1;KOX69333.1;KOX78273.1;KOX69414.1;KOX79626.1;KOX80008.1;KOX70760.1;KOX75968.1;KOX79363.1;KOX77271.1;KOX72982.1;KOX76210.1;KOX78786.1;KOX68313.1;KOX70383.1;KOX71898.1;KOX79039.1;KOX79601.1;KOX70419.1;KOX72105.1;KOX79230.1;KOX73267.1 MetaCyc: PWY-4981 L-proline biosynthesis II (from arginine) 3 KOX79798.1;KOX70089.1;KOX79797.1 MetaCyc: PWY-6453 Stigma estolide biosynthesis 8 KOX75990.1;KOX67923.1;KOX79114.1;KOX67863.1;KOX77858.1;KOX76514.1;KOX80280.1;KOX80284.1 KEGG: 00230+4.1.1.21 Purine metabolism 1 KOX67690.1 MetaCyc: PWY-3581 (S)-reticuline biosynthesis I 1 KOX71846.1 MetaCyc: PWY-6672 Cis-genanyl-coa degradation 1 KOX74892.1 Reactome: R-HSA-400042 Adrenaline,noradrenaline inhibits insulin secretion 5 KOX79467.1;KOX76508.1;KOX69081.1;KOX79656.1;KOX78343.1 Reactome: R-HSA-937072 TRAF6-mediated induction of TAK1 complex within TLR4 complex 6 KOX79430.1;KOX79433.1;KOX72105.1;KOX75998.1;KOX67229.1;KOX68495.1 MetaCyc: PWY-7725 Arachidonate biosynthesis V (8-detaturase, mammals) 21 KOX74597.1;KOX68278.1;KOX78653.1;KOX68279.1;KOX73201.1;KOX78713.1;KOX78236.1;KOX80068.1;KOX78651.1;KOX78660.1;KOX75202.1;KOX78659.1;KOX78654.1;KOX77795.1;KOX67350.1;KOX68696.1;KOX67486.1;KOX79701.1;KOX78657.1;KOX78662.1;KOX78650.1 KEGG: 00051+4.1.2.13 Fructose and mannose metabolism 2 KOX76362.1;KOX76361.1 KEGG: 00450+2.9.1.2 Selenocompound metabolism 1 KOX72747.1 MetaCyc: PWY-3881 Mannitol biosynthesis 1 KOX74805.1 MetaCyc: PWY-7803 Trna splicing II 2 KOX77706.1;KOX80010.1 Reactome: R-HSA-203754 NOSIP mediated eNOS trafficking 1 KOX68862.1 KEGG: 00860+1.3.3.3 Porphyrin and chlorophyll metabolism 1 KOX69203.1 Reactome: R-HSA-6804757 Regulation of TP53 Degradation 13 KOX79433.1;KOX79033.1;KOX78813.1;KOX78362.1;KOX67229.1;KOX75480.1;KOX72105.1;KOX76312.1;KOX72400.1;KOX79430.1;KOX68054.1;KOX69032.1;KOX72981.1 KEGG: 00650+1.3.5.1 Butanoate metabolism 2 KOX68680.1;KOX79955.1 KEGG: 00480+3.4.11.2 Glutathione metabolism 4 KOX81165.1;KOX80947.1;KOX78330.1;KOX78331.1 Reactome: R-HSA-8868766 rRNA processing in the mitochondrion 3 KOX68781.1;KOX70563.1;KOX72874.1 KEGG: 00513+2.4.1.260 Various types of N-glycan biosynthesis 1 KOX77289.1 Reactome: R-HSA-432047 Passive transport by Aquaporins 7 KOX79070.1;KOX75610.1;KOX75611.1;KOX73690.1;KOX79970.1;KOX73691.1;KOX79969.1 Reactome: R-HSA-77588 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 7 KOX73083.1;KOX74908.1;KOX74909.1;KOX73321.1;KOX79387.1;KOX78050.1;KOX78065.1 KEGG: 00562+3.1.3.36 Inositol phosphate metabolism 2 KOX75106.1;KOX74178.1 KEGG: 00240+3.5.2.3 Pyrimidine metabolism 1 KOX80442.1 MetaCyc: PWY-6987 Lipoate biosynthesis and incorporation III (Bacillus) 4 KOX71375.1;KOX75475.1;KOX75142.1;KOX79449.1 Reactome: R-HSA-8874211 CREB3 factors activate genes 2 KOX67594.1;KOX73944.1 Reactome: R-HSA-1632852 Macroautophagy 35 KOX76998.1;KOX74634.1;KOX79612.1;KOX80745.1;KOX68086.1;KOX80754.1;KOX73869.1;KOX79229.1;KOX73089.1;KOX72912.1;KOX76722.1;KOX69422.1;KOX74358.1;KOX79033.1;KOX69814.1;KOX75892.1;KOX75316.1;KOX73802.1;KOX68085.1;KOX78813.1;KOX74572.1;KOX69516.1;KOX80344.1;KOX78128.1;KOX73301.1;KOX81246.1;KOX72777.1;KOX74898.1;KOX69612.1;KOX73172.1;KOX75579.1;KOX73293.1;KOX67725.1;KOX72021.1;KOX80323.1 Reactome: R-HSA-9640463 Wax biosynthesis 25 KOX67582.1;KOX76757.1;KOX70665.1;KOX67276.1;KOX72974.1;KOX70026.1;KOX67575.1;KOX68693.1;KOX72289.1;KOX74747.1;KOX68371.1;KOX76705.1;KOX80980.1;KOX77819.1;KOX76200.1;KOX67284.1;KOX67581.1;KOX74314.1;KOX75132.1;KOX70025.1;KOX67597.1;KOX67285.1;KOX68699.1;KOX68698.1;KOX67261.1 Reactome: R-HSA-3928665 EPH-ephrin mediated repulsion of cells 10 KOX68228.1;KOX69998.1;KOX70021.1;KOX79159.1;KOX76831.1;KOX76387.1;KOX68797.1;KOX73839.1;KOX69299.1;KOX77051.1 Reactome: R-HSA-9026519 Activated NTRK2 signals through RAS 1 KOX81204.1 Reactome: R-HSA-450341 Activation of the AP-1 family of transcription factors 3 KOX73517.1;KOX80039.1;KOX68500.1 Reactome: R-HSA-9009391 Extra-nuclear estrogen signaling 6 KOX78343.1;KOX79656.1;KOX69081.1;KOX70804.1;KOX76508.1;KOX79467.1 KEGG: 00531+3.2.1.35 Glycosaminoglycan degradation 2 KOX79591.1;KOX79590.1 KEGG: 04070+3.1.3.78 Phosphatidylinositol signaling system 1 KOX78048.1 Reactome: R-HSA-1257604 PIP3 activates AKT signaling 10 KOX68497.1;KOX72981.1;KOX73103.1;KOX81204.1;KOX72629.1;KOX72400.1;KOX78813.1;KOX79033.1;KOX70804.1;KOX78362.1 MetaCyc: PWY-5537 Pyruvate fermentation to acetate V 4 KOX74316.1;KOX79891.1;KOX79892.1;KOX79460.1 Reactome: R-HSA-169911 Regulation of Apoptosis 1 KOX73411.1 Reactome: R-HSA-9022537 Loss of MECP2 binding ability to the NCoR/SMRT complex 1 KOX71059.1 Reactome: R-HSA-975574 Reactions specific to the hybrid N-glycan synthesis pathway 1 KOX77791.1 Reactome: R-HSA-196299 Beta-catenin phosphorylation cascade 5 KOX76312.1;KOX73320.1;KOX75788.1;KOX69536.1;KOX71037.1 Reactome: R-HSA-8941333 RUNX2 regulates genes involved in differentiation of myeloid cells 1 KOX79878.1 KEGG: 00010+2.3.1.12 Glycolysis / Gluconeogenesis 1 KOX79834.1 KEGG: 00053+1.13.99.1 Ascorbate and aldarate metabolism 1 KOX74115.1 KEGG: 00720+6.4.1.1 Carbon fixation pathways in prokaryotes 1 KOX68340.1 MetaCyc: PWY-7279 Aerobic respiration II (cytochrome c) (yeast) 3 KOX68680.1;KOX76195.1;KOX79955.1 Reactome: R-HSA-5610780 Degradation of GLI1 by the proteasome 42 KOX78273.1;KOX74139.1;KOX69414.1;KOX69333.1;KOX68748.1;KOX70760.1;KOX72837.1;KOX75968.1;KOX79626.1;KOX80008.1;KOX68313.1;KOX78786.1;KOX70383.1;KOX79363.1;KOX77271.1;KOX72982.1;KOX79230.1;KOX79601.1;KOX72105.1;KOX70419.1;KOX74011.1;KOX73209.1;KOX74910.1;KOX75984.1;KOX74924.1;KOX79433.1;KOX69688.1;KOX80582.1;KOX78268.1;KOX72468.1;KOX71606.1;KOX73060.1;KOX76416.1;KOX67229.1;KOX70009.1;KOX76009.1;KOX72411.1;KOX68314.1;KOX70598.1;KOX76879.1;KOX78266.1;KOX79430.1 Reactome: R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 24 KOX79433.1;KOX69688.1;KOX70798.1;KOX68021.1;KOX76822.1;KOX72931.1;KOX79004.1;KOX78488.1;KOX73591.1;KOX75559.1;KOX69780.1;KOX75699.1;KOX75516.1;KOX80122.1;KOX73600.1;KOX67229.1;KOX80285.1;KOX75429.1;KOX71404.1;KOX69877.1;KOX79430.1;KOX70062.1;KOX72105.1;KOX76312.1 Reactome: R-HSA-9634600 Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 4 KOX74139.1;KOX69286.1;KOX72420.1;KOX76312.1 Reactome: R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 1 KOX70849.1 MetaCyc: PWY-6638 Sulfolactate degradation III 2 KOX79912.1;KOX71428.1 Reactome: R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK 2 KOX75256.1;KOX68500.1 MetaCyc: PWY-7384 Anaerobic energy metabolism (invertebrates, mitochondrial) 5 KOX74316.1;KOX79891.1;KOX79892.1;KOX79460.1;KOX77859.1 Reactome: R-HSA-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation 6 KOX67229.1;KOX79433.1;KOX79430.1;KOX69688.1;KOX80285.1;KOX72105.1 KEGG: 00071+4.2.1.17+1.1.1.211 Fatty acid degradation 1 KOX76405.1 KEGG: 00983+1.1.1.205 Drug metabolism - other enzymes 1 KOX78850.1 KEGG: 00010+4.1.1.32 Glycolysis / Gluconeogenesis 1 KOX68597.1 Reactome: R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 28 KOX71018.1;KOX73198.1;KOX70388.1;KOX81203.1;KOX78035.1;KOX77063.1;KOX67229.1;KOX69719.1;KOX74919.1;KOX67200.1;KOX68485.1;KOX79430.1;KOX72105.1;KOX77626.1;KOX69540.1;KOX77020.1;KOX77023.1;KOX74030.1;KOX70044.1;KOX79433.1;KOX69897.1;KOX81403.1;KOX77062.1;KOX72538.1;KOX79649.1;KOX73785.1;KOX69032.1;KOX71193.1 Reactome: R-HSA-5682910 LGI-ADAM interactions 1 KOX68427.1 KEGG: 00760+2.4.2.1 Nicotinate and nicotinamide metabolism 1 KOX78203.1 KEGG: 00230+1.7.1.7 Purine metabolism 1 KOX76542.1 KEGG: 00670+1.5.1.5+3.5.4.9 One carbon pool by folate 2 KOX77269.1;KOX67514.1 MetaCyc: PWY-7839 Lacto-series glycosphingolipids biosynthesis 1 KOX74918.1 Reactome: R-HSA-6785470 tRNA processing in the mitochondrion 4 KOX68781.1;KOX70563.1;KOX75956.1;KOX72874.1 Reactome: R-HSA-8873719 RAB geranylgeranylation 6 KOX75731.1;KOX68110.1;KOX68050.1;KOX67356.1;KOX71885.1;KOX73109.1 Reactome: R-HSA-1614517 Sulfide oxidation to sulfate 2 KOX67800.1;KOX72740.1 KEGG: 00680+1.1.1.37 Methane metabolism 5 KOX69541.1;KOX70049.1;KOX68928.1;KOX70050.1;KOX75374.1 MetaCyc: PWY-7779 Methyl tert-butyl ether degradation 2 KOX75101.1;KOX76405.1 KEGG: 00230+4.6.1.1 Purine metabolism 4 KOX74111.1;KOX73149.1;KOX78138.1;KOX69402.1 Reactome: R-HSA-8941858 Regulation of RUNX3 expression and activity 39 KOX72982.1;KOX79363.1;KOX77271.1;KOX79878.1;KOX70383.1;KOX68313.1;KOX78786.1;KOX72105.1;KOX79601.1;KOX79230.1;KOX69333.1;KOX68748.1;KOX69414.1;KOX78273.1;KOX80008.1;KOX79626.1;KOX75968.1;KOX70760.1;KOX70009.1;KOX76009.1;KOX73060.1;KOX76416.1;KOX67229.1;KOX76879.1;KOX78266.1;KOX79430.1;KOX70598.1;KOX72411.1;KOX68314.1;KOX79433.1;KOX74924.1;KOX74910.1;KOX75984.1;KOX73209.1;KOX74011.1;KOX71606.1;KOX78268.1;KOX72468.1;KOX80582.1 Reactome: R-HSA-3270619 IRF3-mediated induction of type I IFN 4 KOX67371.1;KOX73082.1;KOX72766.1;KOX68243.1 KEGG: 00900+3.4.24.84 Terpenoid backbone biosynthesis 1 KOX75951.1 KEGG: 00930+4.2.1.17 Caprolactam degradation 1 KOX76405.1 KEGG: 00250+6.3.5.4 Alanine, aspartate and glutamate metabolism 1 KOX69818.1 KEGG: 00362+4.2.1.17 Benzoate degradation 1 KOX76405.1 Reactome: R-HSA-8963901 Chylomicron remodeling 6 KOX75027.1;KOX73976.1;KOX69335.1;KOX68248.1;KOX80996.1;KOX73997.1 KEGG: 00072+2.3.3.10 Synthesis and degradation of ketone bodies 1 KOX70405.1 Reactome: R-HSA-444257 RSK activation 3 KOX78841.1;KOX78362.1;KOX68500.1 KEGG: 00230+3.6.1.6 Purine metabolism 1 KOX72820.1 MetaCyc: PWY-3801 Sucrose degradation II (sucrose synthase) 2 KOX67374.1;KOX67919.1 MetaCyc: PWY-3385 Choline biosynthesis I 1 KOX67207.1 Reactome: R-HSA-5578998 Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) 1 KOX73052.1 Reactome: R-HSA-5632987 Defective Mismatch Repair Associated With PMS2 1 KOX80229.1 KEGG: 00130+2.5.1.39 Ubiquinone and other terpenoid-quinone biosynthesis 1 KOX77776.1 Reactome: R-HSA-427413 NoRC negatively regulates rRNA expression 31 KOX79649.1;KOX81200.1;KOX72538.1;KOX68859.1;KOX81302.1;KOX71680.1;KOX74214.1;KOX73785.1;KOX77963.1;KOX72380.1;KOX71951.1;KOX77062.1;KOX81403.1;KOX74217.1;KOX69897.1;KOX67437.1;KOX75282.1;KOX74640.1;KOX69540.1;KOX74030.1;KOX77626.1;KOX81203.1;KOX70030.1;KOX74441.1;KOX73198.1;KOX74919.1;KOX69719.1;KOX77330.1;KOX72899.1;KOX71263.1;KOX77063.1 MetaCyc: PWY-7601 Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes) 21 KOX74597.1;KOX78653.1;KOX68278.1;KOX78713.1;KOX73201.1;KOX68279.1;KOX78236.1;KOX80068.1;KOX78651.1;KOX78660.1;KOX78659.1;KOX75202.1;KOX78654.1;KOX77795.1;KOX68696.1;KOX67350.1;KOX67486.1;KOX78662.1;KOX78657.1;KOX79701.1;KOX78650.1 MetaCyc: PWY-8099 Tetrahydropteridine recycling 1 KOX75737.1 Reactome: R-HSA-111932 CaMK IV-mediated phosphorylation of CREB 1 KOX68226.1 KEGG: 00561+2.7.7.9 Glycerolipid metabolism 1 KOX67374.1 KEGG: 00740+3.1.3.2 Riboflavin metabolism 9 KOX73842.1;KOX69530.1;KOX80576.1;KOX80574.1;KOX73843.1;KOX74329.1;KOX75677.1;KOX80575.1;KOX79542.1 KEGG: 00640+4.1.1.9 Propanoate metabolism 1 KOX72779.1 Reactome: R-HSA-917937 Iron uptake and transport 7 KOX72105.1;KOX79430.1;KOX79433.1;KOX69688.1;KOX73090.1;KOX70144.1;KOX67229.1 MetaCyc: PWY-7082 Ammonia oxidation IV (autotrophic ammonia oxidizers) 1 KOX76195.1 KEGG: 00640+1.8.1.4 Propanoate metabolism 1 KOX75086.1 Reactome: R-HSA-191273 Cholesterol biosynthesis 5 KOX79462.1;KOX78838.1;KOX74855.1;KOX70146.1;KOX69440.1 Reactome: R-HSA-3371511 HSF1 activation 2 KOX72417.1;KOX70402.1 Reactome: R-HSA-171319 Telomere Extension By Telomerase 3 KOX69059.1;KOX72680.1;KOX80007.1 Reactome: R-HSA-4085001 Sialic acid metabolism 1 KOX69240.1 MetaCyc: PWY-7417 Phospholipid remodeling (phosphatidate, yeast) 14 KOX78316.1;KOX77858.1;KOX79218.1;KOX69497.1;KOX78399.1;KOX67923.1;KOX77917.1;KOX72448.1;KOX79114.1;KOX70330.1;KOX75990.1;KOX78275.1;KOX69576.1;KOX75783.1 MetaCyc: PWY-7863 Roseoflavin biosynthesis 1 KOX78122.1 Reactome: R-HSA-174417 Telomere C-strand (Lagging Strand) Synthesis 4 KOX78024.1;KOX77326.1;KOX77356.1;KOX81364.1 Reactome: R-HSA-112412 SOS-mediated signalling 1 KOX81204.1 MetaCyc: PWY-7820 Teichuronic acid biosynthesis (B. subtilis 168) 1 KOX69806.1 Reactome: R-HSA-5654732 Negative regulation of FGFR3 signaling 6 KOX72105.1;KOX79433.1;KOX79430.1;KOX81204.1;KOX67229.1;KOX68500.1 Reactome: R-HSA-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter 25 KOX77063.1;KOX74448.1;KOX72899.1;KOX72891.1;KOX73198.1;KOX81203.1;KOX77626.1;KOX67688.1;KOX70382.1;KOX77413.1;KOX68645.1;KOX77062.1;KOX67791.1;KOX74451.1;KOX81254.1;KOX76947.1;KOX68921.1;KOX71970.1;KOX77884.1;KOX67394.1;KOX77100.1;KOX75217.1;KOX81200.1;KOX79649.1;KOX80740.1 MetaCyc: PWY-6892 Thiazole biosynthesis I (facultative anaerobic bacteria) 1 KOX69770.1 Reactome: R-HSA-1483115 Hydrolysis of LPC 1 KOX71415.1 Reactome: R-HSA-5362517 Signaling by Retinoic Acid 7 KOX78471.1;KOX76243.1;KOX75086.1;KOX74119.1;KOX79834.1;KOX80546.1;KOX70042.1 Reactome: R-HSA-5357956 TNFR1-induced NFkappaB signaling pathway 8 KOX67229.1;KOX72543.1;KOX79433.1;KOX73463.1;KOX79430.1;KOX72105.1;KOX75998.1;KOX78046.1 KEGG: 00240+4.1.1.23 Pyrimidine metabolism 1 KOX71473.1 MetaCyc: PWY-6111 Mitochondrial L-carnitine shuttle 1 KOX81081.1 Reactome: R-HSA-5659996 RPIA deficiency: failed conversion of R5P to RU5P 1 KOX80223.1 Reactome: R-HSA-2161541 Abacavir metabolism 1 KOX78842.1 Reactome: R-HSA-2393930 Phosphate bond hydrolysis by NUDT proteins 4 KOX77552.1;KOX73945.1;KOX74019.1;KOX77507.1 MetaCyc: PWY-5103 L-isoleucine biosynthesis III 1 KOX72274.1 KEGG: 00270+2.5.1.22 Cysteine and methionine metabolism 1 KOX80905.1 MetaCyc: PWY-7053 Docosahexaenoate biosynthesis I (lower eukaryotes) 2 KOX79701.1;KOX78236.1 Reactome: R-HSA-74749 Signal attenuation 2 KOX68500.1;KOX81204.1 Reactome: R-HSA-1483255 PI Metabolism 1 KOX76262.1 Reactome: R-HSA-8940973 RUNX2 regulates osteoblast differentiation 3 KOX68500.1;KOX80895.1;KOX79878.1 KEGG: 00240+2.7.4.14 Pyrimidine metabolism 1 KOX77775.1 Reactome: R-HSA-9604323 Negative regulation of NOTCH4 signaling 39 KOX69414.1;KOX78273.1;KOX68748.1;KOX69333.1;KOX75968.1;KOX70760.1;KOX80008.1;KOX79626.1;KOX70383.1;KOX78786.1;KOX68313.1;KOX72982.1;KOX77271.1;KOX79363.1;KOX79230.1;KOX72105.1;KOX79601.1;KOX73209.1;KOX74011.1;KOX69688.1;KOX79433.1;KOX74924.1;KOX75984.1;KOX74910.1;KOX80582.1;KOX71606.1;KOX72468.1;KOX78268.1;KOX76416.1;KOX67229.1;KOX73060.1;KOX76009.1;KOX70009.1;KOX70598.1;KOX68314.1;KOX72411.1;KOX79430.1;KOX78266.1;KOX76879.1 Reactome: R-HSA-975110 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling 5 KOX79433.1;KOX79430.1;KOX72105.1;KOX67229.1;KOX68497.1 Reactome: R-HSA-375280 Amine ligand-binding receptors 1 KOX70346.1 KEGG: 00970+6.1.1.21 Aminoacyl-tRNA biosynthesis 1 KOX69801.1 MetaCyc: PWY-6664 Di-myo-inositol phosphate biosynthesis 1 KOX68055.1 Reactome: R-HSA-112043 PLC beta mediated events 5 KOX74728.1;KOX73812.1;KOX74177.1;KOX75330.1;KOX67335.1 MetaCyc: PWY-3861 Mannitol degradation II 1 KOX74805.1 MetaCyc: PWY-5789 3-hydroxypropanoate/4-hydroxybutanate cycle 7 KOX80775.1;KOX75101.1;KOX68087.1;KOX68932.1;KOX76405.1;KOX79144.1;KOX70011.1 KEGG: 00062+4.2.1.17+1.1.1.211 Fatty acid elongation 1 KOX76405.1 KEGG: 00330+1.5.1.2 Arginine and proline metabolism 1 KOX70089.1 Reactome: R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 2 KOX81204.1;KOX73812.1 Reactome: R-HSA-212436 Generic Transcription Pathway 24 KOX74632.1;KOX74616.1;KOX74031.1;KOX71879.1;KOX72451.1;KOX77181.1;KOX71552.1;KOX68229.1;KOX70259.1;KOX71407.1;KOX80746.1;KOX72224.1;KOX68771.1;KOX78565.1;KOX68963.1;KOX78127.1;KOX72486.1;KOX70422.1;KOX79676.1;KOX67461.1;KOX70975.1;KOX68772.1;KOX68040.1;KOX70063.1 Reactome: R-HSA-113418 Formation of the Early Elongation Complex 27 KOX69719.1;KOX74919.1;KOX68573.1;KOX69424.1;KOX70730.1;KOX77063.1;KOX81203.1;KOX73198.1;KOX74030.1;KOX69540.1;KOX70044.1;KOX77626.1;KOX78553.1;KOX77418.1;KOX74945.1;KOX67200.1;KOX81403.1;KOX77062.1;KOX69897.1;KOX74908.1;KOX80159.1;KOX74806.1;KOX74909.1;KOX73785.1;KOX71506.1;KOX79649.1;KOX72538.1 MetaCyc: PWY-6118 Glycerol-3-phosphate shuttle 3 KOX78959.1;KOX75465.1;KOX75460.1 Reactome: R-HSA-176412 Phosphorylation of the APC/C 9 KOX73267.1;KOX71992.1;KOX72154.1;KOX79389.1;KOX71898.1;KOX76684.1;KOX76210.1;KOX74256.1;KOX72749.1 KEGG: 00710+5.3.1.1 Carbon fixation in photosynthetic organisms 1 KOX67171.1 Reactome: R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 10 KOX79430.1;KOX72105.1;KOX79433.1;KOX72153.1;KOX70054.1;KOX69604.1;KOX67799.1;KOX80899.1;KOX67229.1;KOX74031.1 Reactome: R-HSA-375165 NCAM signaling for neurite out-growth 2 KOX68500.1;KOX81204.1 Reactome: R-HSA-4043916 Defective MPI causes MPI-CDG (CDG-1b) 1 KOX74805.1 KEGG: 00230+3.6.1.66 Purine metabolism 1 KOX69334.1 KEGG: 04150+2.7.11.11 mTOR signaling pathway 1 KOX74139.1 MetaCyc: PWY-6886 1-butanol autotrophic biosynthesis (engineered) 5 KOX74975.1;KOX67203.1;KOX71859.1;KOX74974.1;KOX81104.1 KEGG: 00562+2.7.1.67 Inositol phosphate metabolism 1 KOX79807.1 KEGG: 00230+3.1.4.53 Purine metabolism 2 KOX73490.1;KOX73489.1 KEGG: 00620+1.2.4.1 Pyruvate metabolism 4 KOX70042.1;KOX74119.1;KOX78471.1;KOX76243.1 KEGG: 00760+3.1.3.5 Nicotinate and nicotinamide metabolism 2 KOX75971.1;KOX75972.1 Reactome: R-HSA-166016 Toll Like Receptor 4 (TLR4) Cascade 1 KOX70849.1 KEGG: 00513+2.4.1.68 Various types of N-glycan biosynthesis 1 KOX77864.1 Reactome: R-HSA-1912399 Pre-NOTCH Processing in the Endoplasmic Reticulum 2 KOX71405.1;KOX69108.1 MetaCyc: PWY-5486 Pyruvate fermentation to ethanol II 1 KOX67600.1 Reactome: R-HSA-2024101 CS/DS degradation 4 KOX74631.1;KOX73530.1;KOX81256.1;KOX74285.1 Reactome: R-HSA-418886 Netrin mediated repulsion signals 2 KOX77995.1;KOX77999.1 MetaCyc: PWY-1187 Glucosinolate biosynthesis from homomethionine 1 KOX80071.1 Reactome: R-HSA-2243919 Crosslinking of collagen fibrils 4 KOX75715.1;KOX72728.1;KOX75720.1;KOX75270.1 Reactome: R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK 19 KOX75316.1;KOX67725.1;KOX69814.1;KOX81246.1;KOX72777.1;KOX80900.1;KOX74358.1;KOX79033.1;KOX69422.1;KOX72912.1;KOX73089.1;KOX74479.1;KOX78128.1;KOX73869.1;KOX80754.1;KOX68086.1;KOX68085.1;KOX80745.1;KOX78813.1 Reactome: R-HSA-5683826 Surfactant metabolism 2 KOX71685.1;KOX76388.1 MetaCyc: PWY-7282 4-amino-2-methyl-5-phosphomethylpyrimidine biosynthesis 4 KOX70645.1;KOX80439.1;KOX67899.1;KOX67689.1 MetaCyc: PWY-5653 NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde 2 KOX80677.1;KOX78680.1 KEGG: 00240+2.7.1.48 Pyrimidine metabolism 2 KOX78077.1;KOX79373.1 KEGG: 00510+2.4.1.257+2.4.1.132 N-Glycan biosynthesis 1 KOX71738.1 KEGG: 00230+2.1.2.2 Purine metabolism 1 KOX79954.1 Reactome: R-HSA-9665250 Resistance of ERBB2 KD mutants to AEE788 1 KOX73791.1 KEGG: 00030+4.1.2.13 Pentose phosphate pathway 2 KOX76362.1;KOX76361.1 MetaCyc: PWY-7401 Crotonate fermentation (to acetate and cyclohexane carboxylate) 2 KOX75101.1;KOX76405.1 Reactome: R-HSA-9014325 TICAM1,TRAF6-dependent induction of TAK1 complex 5 KOX75998.1;KOX72105.1;KOX79430.1;KOX79433.1;KOX67229.1 Reactome: R-HSA-110331 Cleavage of the damaged purine 5 KOX67788.1;KOX77330.1;KOX74214.1;KOX70328.1;KOX74217.1 Reactome: R-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity 5 KOX77633.1;KOX67229.1;KOX72105.1;KOX79433.1;KOX79430.1 KEGG: 00720+6.3.4.3 Carbon fixation pathways in prokaryotes 3 KOX77269.1;KOX69389.1;KOX69388.1 Reactome: R-HSA-3299685 Detoxification of Reactive Oxygen Species 23 KOX76220.1;KOX80161.1;KOX69899.1;KOX78094.1;KOX71264.1;KOX74953.1;KOX69197.1;KOX68947.1;KOX69212.1;KOX67775.1;KOX79420.1;KOX69910.1;KOX80160.1;KOX80990.1;KOX75562.1;KOX68555.1;KOX72875.1;KOX75462.1;KOX69198.1;KOX74205.1;KOX71017.1;KOX76704.1;KOX73557.1 Reactome: R-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC 14 KOX76507.1;KOX78324.1;KOX67167.1;KOX67484.1;KOX78382.1;KOX69885.1;KOX69602.1;KOX76721.1;KOX76688.1;KOX70512.1;KOX81218.1;KOX73881.1;KOX78965.1;KOX69322.1 MetaCyc: PWY-5076 L-leucine degradation III 2 KOX67600.1;KOX72274.1 Reactome: R-HSA-8866904 Negative regulation of activity of TFAP2 (AP-2) family transcription factors 1 KOX73958.1 MetaCyc: PWY-7268 NAD/NADP-NADH/NADPH cytosolic interconversion (yeast) 3 KOX79046.1;KOX79573.1;KOX73807.1 Reactome: R-HSA-2644607 Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling 1 KOX69688.1 Reactome: R-HSA-442720 CREB1 phosphorylation through the activation of Adenylate Cyclase 2 KOX71184.1;KOX74139.1 KEGG: 00860+2.5.1.141 Porphyrin and chlorophyll metabolism 1 KOX78502.1 MetaCyc: PWY-5675 Nitrate reduction V (assimilatory) 1 KOX75490.1 MetaCyc: PWY-7230 Ubiquinol-6 biosynthesis from 4-aminobenzoate (yeast) 2 KOX72023.1;KOX70323.1 KEGG: 00350+1.14.16.2 Tyrosine metabolism 1 KOX71846.1 Reactome: R-HSA-5654693 FRS-mediated FGFR1 signaling 2 KOX67928.1;KOX81204.1 Reactome: R-HSA-205043 NRIF signals cell death from the nucleus 9 KOX77051.1;KOX72105.1;KOX79430.1;KOX67229.1;KOX73643.1;KOX70021.1;KOX69998.1;KOX68228.1;KOX79433.1 MetaCyc: PWY-6944 Androstenedione degradation 2 KOX75101.1;KOX76405.1 Reactome: R-HSA-114516 Disinhibition of SNARE formation 1 KOX79275.1 KEGG: 00860+4.1.1.37 Porphyrin and chlorophyll metabolism 1 KOX75988.1 MetaCyc: PWY-5740 GDP-L-colitose biosynthesis 1 KOX69413.1 Reactome: R-HSA-1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 2 KOX73788.1;KOX80540.1 KEGG: 00480+2.3.2.2+3.4.19.13 Glutathione metabolism 3 KOX71346.1;KOX78785.1;KOX79924.1 KEGG: 04150+2.7.11.24 mTOR signaling pathway 4 KOX80039.1;KOX68500.1;KOX71145.1;KOX73063.1 MetaCyc: PWY-6596 Adenosine nucleotides degradation I 5 KOX75972.1;KOX71781.1;KOX74844.1;KOX78850.1;KOX75971.1 Reactome: R-HSA-5624958 ARL13B-mediated ciliary trafficking of INPP5E 1 KOX79598.1 MetaCyc: PWY-3561 Choline biosynthesis III 1 KOX74104.1 MetaCyc: PWY-7790 UMP biosynthesis II 3 KOX71473.1;KOX80440.1;KOX80442.1 MetaCyc: PWY-5278 Sulfite oxidation III 2 KOX68057.1;KOX74601.1 Reactome: R-HSA-196025 Formation of annular gap junctions 2 KOX76831.1;KOX69299.1 MetaCyc: PWY-6146 Methanobacterium thermoautotrophicum biosynthetic metabolism 1 KOX68340.1 Reactome: R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat 33 KOX81203.1;KOX67799.1;KOX69719.1;KOX74919.1;KOX69424.1;KOX77418.1;KOX67200.1;KOX72082.1;KOX78553.1;KOX74030.1;KOX77062.1;KOX74908.1;KOX79649.1;KOX73785.1;KOX71506.1;KOX74909.1;KOX78696.1;KOX73198.1;KOX67622.1;KOX68573.1;KOX77063.1;KOX70730.1;KOX74945.1;KOX81395.1;KOX77626.1;KOX70044.1;KOX69540.1;KOX74806.1;KOX80159.1;KOX81403.1;KOX69897.1;KOX72538.1;KOX75987.1 Reactome: R-HSA-5654695 PI-3K cascade:FGFR2 1 KOX81204.1 MetaCyc: PWY-2821 Glucosinolate biosynthesis from phenylalanine 1 KOX80071.1 KEGG: 00592+1.1.1.1 alpha-Linolenic acid metabolism 1 KOX67600.1 MetaCyc: PWY-7802 N-end rule pathway II (prokaryotic) 1 KOX79842.1 Reactome: R-HSA-389357 CD28 dependent PI3K/Akt signaling 6 KOX72400.1;KOX78813.1;KOX79033.1;KOX72981.1;KOX78362.1;KOX70804.1 Reactome: R-HSA-4724325 Defective ALG8 causes ALG8-CDG (CDG-1h) 1 KOX72002.1 Reactome: R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA 40 KOX72982.1;KOX77271.1;KOX79363.1;KOX70383.1;KOX78786.1;KOX68313.1;KOX70419.1;KOX72105.1;KOX79601.1;KOX79230.1;KOX68748.1;KOX69333.1;KOX69414.1;KOX78273.1;KOX80008.1;KOX79626.1;KOX75968.1;KOX70760.1;KOX76009.1;KOX70009.1;KOX69831.1;KOX76416.1;KOX67229.1;KOX73060.1;KOX79430.1;KOX76879.1;KOX78266.1;KOX70598.1;KOX68314.1;KOX72411.1;KOX79433.1;KOX74924.1;KOX75984.1;KOX74910.1;KOX73209.1;KOX74011.1;KOX71606.1;KOX72468.1;KOX78268.1;KOX80582.1 Reactome: R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 49 KOX73267.1;KOX79230.1;KOX72105.1;KOX70419.1;KOX71898.1;KOX79601.1;KOX70383.1;KOX68313.1;KOX78786.1;KOX72982.1;KOX76415.1;KOX76210.1;KOX79363.1;KOX77271.1;KOX75968.1;KOX70760.1;KOX80008.1;KOX79626.1;KOX69414.1;KOX78273.1;KOX69333.1;KOX68748.1;KOX74256.1;KOX70598.1;KOX72411.1;KOX68314.1;KOX72154.1;KOX78266.1;KOX76879.1;KOX79430.1;KOX76684.1;KOX73060.1;KOX76416.1;KOX67229.1;KOX70009.1;KOX76009.1;KOX71992.1;KOX80582.1;KOX79389.1;KOX71606.1;KOX78268.1;KOX72468.1;KOX73209.1;KOX74011.1;KOX74924.1;KOX79433.1;KOX74910.1;KOX72749.1;KOX75984.1 KEGG: 00730+3.1.3.1 Thiamine metabolism 4 KOX73014.1;KOX79580.1;KOX74128.1;KOX73008.1 KEGG: 00520+3.2.1.14 Amino sugar and nucleotide sugar metabolism 6 KOX79466.1;KOX75966.1;KOX79324.1;KOX72270.1;KOX79627.1;KOX77106.1 Reactome: R-HSA-5628897 TP53 Regulates Metabolic Genes 44 KOX80357.1;KOX74953.1;KOX75223.1;KOX69899.1;KOX67725.1;KOX74484.1;KOX75562.1;KOX78128.1;KOX75491.1;KOX75228.1;KOX81246.1;KOX72777.1;KOX76310.1;KOX69086.1;KOX74760.1;KOX69910.1;KOX72400.1;KOX74653.1;KOX68085.1;KOX78813.1;KOX69814.1;KOX69543.1;KOX75316.1;KOX78094.1;KOX72912.1;KOX73089.1;KOX70201.1;KOX72878.1;KOX67919.1;KOX70326.1;KOX74358.1;KOX79033.1;KOX69422.1;KOX79963.1;KOX74580.1;KOX68086.1;KOX68332.1;KOX67889.1;KOX73869.1;KOX80754.1;KOX72046.1;KOX73387.1;KOX80745.1;KOX67865.1 Reactome: R-HSA-211163 AKT-mediated inactivation of FOXO1A 1 KOX72400.1 KEGG: 00260+3.1.3.3 Glycine, serine and threonine metabolism 1 KOX78490.1 Reactome: R-HSA-3134963 DEx/H-box helicases activate type I IFN and inflammatory cytokines production 1 KOX68497.1 KEGG: 00900+2.5.1.87 Terpenoid backbone biosynthesis 1 KOX80579.1 Reactome: R-HSA-2142700 Synthesis of Lipoxins (LX) 1 KOX69991.1 Reactome: R-HSA-5693607 Processing of DNA double-strand break ends 38 KOX71424.1;KOX70402.1;KOX68243.1;KOX72105.1;KOX79035.1;KOX72417.1;KOX79987.1;KOX77330.1;KOX73285.1;KOX68199.1;KOX69173.1;KOX73599.1;KOX73670.1;KOX72024.1;KOX74214.1;KOX75506.1;KOX79548.1;KOX79522.1;KOX68669.1;KOX68522.1;KOX72221.1;KOX75011.1;KOX79065.1;KOX79196.1;KOX80991.1;KOX71763.1;KOX71786.1;KOX79430.1;KOX68054.1;KOX67229.1;KOX74923.1;KOX74812.1;KOX75006.1;KOX80977.1;KOX67692.1;KOX74217.1;KOX71452.1;KOX79433.1 KEGG: 00603+3.2.1.22 Glycosphingolipid biosynthesis - globo and isoglobo series 1 KOX70065.1 KEGG: 00561+2.3.1.51 Glycerolipid metabolism 4 KOX79114.1;KOX67923.1;KOX77858.1;KOX75990.1 Reactome: R-HSA-418885 DCC mediated attractive signaling 2 KOX76191.1;KOX78779.1 Reactome: R-HSA-212300 PRC2 methylates histones and DNA 9 KOX77330.1;KOX74217.1;KOX77963.1;KOX67632.1;KOX74005.1;KOX74441.1;KOX74214.1;KOX73880.1;KOX68069.1 Reactome: R-HSA-199418 Negative regulation of the PI3K/AKT network 1 KOX72400.1 Reactome: R-HSA-912526 Interleukin receptor SHC signaling 2 KOX81204.1;KOX70804.1 KEGG: 00010+5.3.1.9 Glycolysis / Gluconeogenesis 1 KOX67919.1 MetaCyc: PWY-6854 Ethylene biosynthesis III (microbes) 6 KOX68947.1;KOX80990.1;KOX69197.1;KOX67775.1;KOX68555.1;KOX69198.1 MetaCyc: PWY-6614 Tetrahydrofolate biosynthesis 1 KOX80540.1 Reactome: R-HSA-112308 Presynaptic depolarization and calcium channel opening 2 KOX80744.1;KOX69225.1 KEGG: 00230+3.5.2.17 Purine metabolism 1 KOX78431.1 KEGG: 00730+2.2.1.7 Thiamine metabolism 1 KOX69770.1 MetaCyc: PWY-7456 Beta-(1,4)-mannan degradation 2 KOX72772.1;KOX74805.1 Reactome: R-HSA-5083632 Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) 1 KOX71619.1 KEGG: 00680+4.1.2.13 Methane metabolism 2 KOX76362.1;KOX76361.1 Reactome: R-HSA-210991 Basigin interactions 1 KOX71035.1 Reactome: R-HSA-2428933 SHC-related events triggered by IGF1R 1 KOX81204.1 KEGG: 00030+1.1.1.47 Pentose phosphate pathway 1 KOX69522.1 MetaCyc: PWY-241 C4 photosynthetic carbon assimilation cycle, NADP-ME type 3 KOX68087.1;KOX68932.1;KOX80775.1 Reactome: R-HSA-156588 Glucuronidation 6 KOX77373.1;KOX67539.1;KOX67538.1;KOX75377.1;KOX67540.1;KOX70596.1 Reactome: R-HSA-174490 Membrane binding and targetting of GAG proteins 9 KOX79433.1;KOX72168.1;KOX67229.1;KOX80074.1;KOX72105.1;KOX79430.1;KOX78305.1;KOX71636.1;KOX69076.1 KEGG: 00250+4.3.2.1 Alanine, aspartate and glutamate metabolism 1 KOX81392.1 MetaCyc: PWY-5136 Fatty acid beta-oxidation II (plant peroxisome) 4 KOX71616.1;KOX76405.1;KOX75101.1;KOX73119.1 Reactome: R-HSA-70688 Proline catabolism 1 KOX67769.1 KEGG: 00720+4.2.1.3 Carbon fixation pathways in prokaryotes 2 KOX71536.1;KOX73090.1 KEGG: 00020+1.2.4.1 Citrate cycle (TCA cycle) 4 KOX78471.1;KOX76243.1;KOX74119.1;KOX70042.1 Reactome: R-HSA-162791 Attachment of GPI anchor to uPAR 6 KOX68046.1;KOX74482.1;KOX73990.1;KOX74552.1;KOX77550.1;KOX76767.1 MetaCyc: PWY-6317 D-galactose degradation I (Leloir pathway) 5 KOX67564.1;KOX68891.1;KOX77926.1;KOX72084.1;KOX67206.1 Reactome: R-HSA-1170546 Prolactin receptor signaling 2 KOX69723.1;KOX69688.1 Reactome: R-HSA-933541 TRAF6 mediated IRF7 activation 2 KOX70261.1;KOX69665.1 Reactome: R-HSA-4641263 Regulation of FZD by ubiquitination 4 KOX67229.1;KOX79433.1;KOX79430.1;KOX72105.1 Reactome: R-HSA-167158 Formation of the HIV-1 Early Elongation Complex 27 KOX74909.1;KOX71506.1;KOX73785.1;KOX72538.1;KOX79649.1;KOX69897.1;KOX74908.1;KOX77062.1;KOX81403.1;KOX80159.1;KOX74806.1;KOX74030.1;KOX69540.1;KOX70044.1;KOX78553.1;KOX77626.1;KOX67200.1;KOX77418.1;KOX74945.1;KOX68573.1;KOX69424.1;KOX70730.1;KOX77063.1;KOX74919.1;KOX69719.1;KOX73198.1;KOX81203.1 Reactome: R-HSA-5689880 Ub-specific processing proteases 64 KOX70760.1;KOX70197.1;KOX68742.1;KOX75968.1;KOX72916.1;KOX75506.1;KOX69333.1;KOX68748.1;KOX69085.1;KOX68673.1;KOX72105.1;KOX71483.1;KOX68313.1;KOX70383.1;KOX78854.1;KOX79363.1;KOX78488.1;KOX78268.1;KOX71940.1;KOX73331.1;KOX80121.1;KOX74910.1;KOX75984.1;KOX79433.1;KOX79675.1;KOX78266.1;KOX73060.1;KOX76416.1;KOX70173.1;KOX79626.1;KOX75998.1;KOX80008.1;KOX78273.1;KOX69414.1;KOX76998.1;KOX79628.1;KOX79230.1;KOX80851.1;KOX69059.1;KOX79601.1;KOX70426.1;KOX70419.1;KOX69590.1;KOX78786.1;KOX77271.1;KOX72982.1;KOX69032.1;KOX80582.1;KOX72468.1;KOX71606.1;KOX70085.1;KOX74011.1;KOX73209.1;KOX71427.1;KOX74924.1;KOX68335.1;KOX68314.1;KOX72411.1;KOX70598.1;KOX76879.1;KOX79430.1;KOX67229.1;KOX70009.1;KOX76009.1 KEGG: 00640+1.3.3.6 Propanoate metabolism 2 KOX71616.1;KOX73119.1 KEGG: 04070+3.1.3.66 Phosphatidylinositol signaling system 1 KOX78498.1 KEGG: 00071+1.1.1.1 Fatty acid degradation 1 KOX67600.1 KEGG: 00626+1.1.1.1 Naphthalene degradation 1 KOX67600.1 MetaCyc: PWY-7511 Protein ubiquitination 87 KOX73258.1;KOX71819.1;KOX79864.1;KOX72159.1;KOX71695.1;KOX76669.1;KOX72031.1;KOX79296.1;KOX75808.1;KOX69597.1;KOX75810.1;KOX68238.1;KOX75373.1;KOX78291.1;KOX70197.1;KOX80222.1;KOX81243.1;KOX80741.1;KOX79044.1;KOX75809.1;KOX73890.1;KOX74906.1;KOX71006.1;KOX68745.1;KOX68673.1;KOX72478.1;KOX78489.1;KOX69377.1;KOX76311.1;KOX68756.1;KOX76292.1;KOX69771.1;KOX73303.1;KOX74252.1;KOX69986.1;KOX79957.1;KOX80132.1;KOX67368.1;KOX79458.1;KOX79031.1;KOX69095.1;KOX73030.1;KOX71763.1;KOX71391.1;KOX68485.1;KOX71654.1;KOX81371.1;KOX68486.1;KOX72753.1;KOX77015.1;KOX80786.1;KOX72383.1;KOX72138.1;KOX68475.1;KOX71741.1;KOX68324.1;KOX73852.1;KOX68526.1;KOX75362.1;KOX72702.1;KOX75603.1;KOX80388.1;KOX77800.1;KOX74204.1;KOX67413.1;KOX77583.1;KOX70000.1;KOX78296.1;KOX70394.1;KOX69376.1;KOX69201.1;KOX73811.1;KOX75898.1;KOX77551.1;KOX73105.1;KOX67692.1;KOX70780.1;KOX69004.1;KOX77014.1;KOX69695.1;KOX79197.1;KOX72784.1;KOX71004.1;KOX68728.1;KOX71393.1;KOX68523.1;KOX67348.1 MetaCyc: PWY-5392 Reductive TCA cycle II 10 KOX69541.1;KOX70049.1;KOX79892.1;KOX77859.1;KOX70050.1;KOX74316.1;KOX68928.1;KOX79891.1;KOX75374.1;KOX79460.1 Reactome: R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 2 KOX74914.1;KOX68497.1 Reactome: R-HSA-8854518 AURKA Activation by TPX2 19 KOX68021.1;KOX70798.1;KOX76822.1;KOX72931.1;KOX75559.1;KOX69780.1;KOX79004.1;KOX78488.1;KOX73591.1;KOX75583.1;KOX75699.1;KOX75516.1;KOX80122.1;KOX73600.1;KOX73848.1;KOX75429.1;KOX69877.1;KOX71404.1;KOX76312.1 KEGG: 00860+4.2.1.75 Porphyrin and chlorophyll metabolism 1 KOX78820.1 MetaCyc: PWY-8086 (S)-lactate fermentation to propanoate, acetate and hydrogen 9 KOX77687.1;KOX69541.1;KOX70049.1;KOX77859.1;KOX68928.1;KOX70050.1;KOX68340.1;KOX75374.1;KOX77688.1 MetaCyc: PWY-7187 Pyrimidine deoxyribonucleotides de novo biosynthesis II 8 KOX80826.1;KOX76865.1;KOX78158.1;KOX71982.1;KOX78412.1;KOX69334.1;KOX71458.1;KOX79122.1 KEGG: 00564+3.1.3.4 Glycerophospholipid metabolism 2 KOX80284.1;KOX67863.1 KEGG: 00521+5.5.1.4 Streptomycin biosynthesis 1 KOX68055.1 KEGG: 00670+2.1.2.10 One carbon pool by folate 4 KOX79396.1;KOX74361.1;KOX67693.1;KOX71509.1 MetaCyc: PWY-6643 Coenzyme M biosynthesis II 2 KOX71428.1;KOX79912.1 Reactome: R-HSA-8963888 Chylomicron assembly 9 KOX73976.1;KOX74771.1;KOX80996.1;KOX73997.1;KOX68248.1;KOX69335.1;KOX73734.1;KOX73736.1;KOX73735.1 Reactome: R-HSA-9657050 Defective OGG1 Localization 1 KOX70328.1 MetaCyc: PWY-6981 Chitin biosynthesis 3 KOX80907.1;KOX68961.1;KOX67919.1 MetaCyc: PWY-6482 Diphthamide biosynthesis I (archaea) 3 KOX81155.1;KOX77355.1;KOX77844.1 MetaCyc: PWY-5538 Pyruvate fermentation to acetate VI 4 KOX74316.1;KOX79460.1;KOX79891.1;KOX79892.1 Reactome: R-HSA-2871837 FCERI mediated NF-kB activation 43 KOX79230.1;KOX72105.1;KOX70419.1;KOX79601.1;KOX70383.1;KOX68313.1;KOX78786.1;KOX80285.1;KOX72982.1;KOX79363.1;KOX77271.1;KOX75968.1;KOX70760.1;KOX80008.1;KOX75998.1;KOX79626.1;KOX69414.1;KOX78273.1;KOX78362.1;KOX69333.1;KOX68748.1;KOX70598.1;KOX68314.1;KOX72411.1;KOX78266.1;KOX76879.1;KOX79430.1;KOX73060.1;KOX76416.1;KOX67229.1;KOX70009.1;KOX76009.1;KOX80582.1;KOX71606.1;KOX78268.1;KOX72468.1;KOX73209.1;KOX74011.1;KOX79433.1;KOX74924.1;KOX69688.1;KOX74910.1;KOX75984.1 KEGG: 00785+2.3.1.181 Lipoic acid metabolism 3 KOX79449.1;KOX75475.1;KOX71375.1 MetaCyc: PWY-8012 Mupirocin biosynthesis 2 KOX69550.1;KOX73549.1 KEGG: 00051+2.7.1.105+3.1.3.46 Fructose and mannose metabolism 2 KOX69286.1;KOX72420.1 MetaCyc: PWY-5738 GDP-6-deoxy-D-talose biosynthesis 1 KOX69413.1 MetaCyc: PWY-7238 Sucrose biosynthesis II 4 KOX80377.1;KOX67919.1;KOX74487.1;KOX67374.1 KEGG: 00480+6.3.2.3 Glutathione metabolism 1 KOX76540.1 MetaCyc: PWY-7807 Glyphosate degradation III 3 KOX68266.1;KOX74349.1;KOX78499.1 MetaCyc: PWY-7179-1 Purine deoxyribonucleosides degradation II 2 KOX78203.1;KOX71685.1 MetaCyc: PWY-7798 Protein S-nitrosylation and denitrosylation 1 KOX67600.1 Reactome: R-HSA-73817 Purine ribonucleoside monophosphate biosynthesis 9 KOX78850.1;KOX71802.1;KOX81300.1;KOX71530.1;KOX79954.1;KOX70064.1;KOX67689.1;KOX80463.1;KOX67690.1 Reactome: R-HSA-8939246 RUNX1 regulates transcription of genes involved in differentiation of myeloid cells 1 KOX79878.1 MetaCyc: PWY-6598 Sciadonate biosynthesis 21 KOX67486.1;KOX78657.1;KOX78662.1;KOX79701.1;KOX78650.1;KOX78654.1;KOX77795.1;KOX68696.1;KOX67350.1;KOX80068.1;KOX78660.1;KOX78651.1;KOX78659.1;KOX75202.1;KOX74597.1;KOX78653.1;KOX68278.1;KOX78713.1;KOX68279.1;KOX73201.1;KOX78236.1 Reactome: R-HSA-3359463 Defective CUBN causes hereditary megaloblastic anemia 1 1 KOX71101.1 MetaCyc: PWY-5973 Cis-vaccenate biosynthesis 2 KOX69550.1;KOX73549.1 Reactome: R-HSA-9609690 HCMV Early Events 44 KOX75539.1;KOX72429.1;KOX77330.1;KOX71059.1;KOX79436.1;KOX72164.1;KOX77793.1;KOX73226.1;KOX72161.1;KOX69061.1;KOX72473.1;KOX72163.1;KOX72162.1;KOX70129.1;KOX69879.1;KOX77058.1;KOX78693.1;KOX72302.1;KOX75540.1;KOX74214.1;KOX79744.1;KOX79174.1;KOX68874.1;KOX79242.1;KOX75272.1;KOX75480.1;KOX80793.1;KOX75630.1;KOX68198.1;KOX78183.1;KOX72843.1;KOX80341.1;KOX72021.1;KOX68732.1;KOX68069.1;KOX74217.1;KOX72895.1;KOX73664.1;KOX77505.1;KOX73131.1;KOX75211.1;KOX73880.1;KOX75811.1;KOX81376.1 MetaCyc: PWY-5870 Ubiquinol-8 biosynthesis (eukaryotic) 3 KOX77776.1;KOX72023.1;KOX70323.1 Reactome: R-HSA-5610787 Hedgehog 'off' state 14 KOX80369.1;KOX74139.1;KOX68047.1;KOX73149.1;KOX74168.1;KOX69667.1;KOX69402.1;KOX75331.1;KOX76340.1;KOX68621.1;KOX72202.1;KOX72837.1;KOX71184.1;KOX78138.1 KEGG: 00072+4.1.3.4 Synthesis and degradation of ketone bodies 1 KOX72741.1 KEGG: 00790+1.14.16.4 Folate biosynthesis 1 KOX81148.1 KEGG: 00710+1.1.1.37 Carbon fixation in photosynthetic organisms 5 KOX68928.1;KOX69541.1;KOX70049.1;KOX70050.1;KOX75374.1 MetaCyc: PWY-6613 Tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate 3 KOX77269.1;KOX67514.1;KOX79954.1 Reactome: R-HSA-8983432 Interleukin-15 signaling 1 KOX81204.1 KEGG: 00430+1.13.11.20 Taurine and hypotaurine metabolism 1 KOX69327.1 Reactome: R-HSA-388841 Costimulation by the CD28 family 2 KOX81204.1;KOX70804.1 MetaCyc: PWY-7118 Chitin degradation to ethanol 2 KOX67600.1;KOX74892.1 KEGG: 00620+3.6.1.7 Pyruvate metabolism 1 KOX78240.1 Reactome: R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 47 KOX79369.1;KOX71452.1;KOX74930.1;KOX79433.1;KOX74812.1;KOX74923.1;KOX80977.1;KOX74962.1;KOX81246.1;KOX67229.1;KOX77364.1;KOX73848.1;KOX77334.1;KOX79196.1;KOX71763.1;KOX80991.1;KOX79430.1;KOX68054.1;KOX71518.1;KOX71786.1;KOX79522.1;KOX68669.1;KOX75489.1;KOX68559.1;KOX69085.1;KOX73670.1;KOX73599.1;KOX69173.1;KOX75987.1;KOX72024.1;KOX75583.1;KOX78263.1;KOX79548.1;KOX71363.1;KOX79987.1;KOX72417.1;KOX74479.1;KOX73285.1;KOX71424.1;KOX75316.1;KOX70402.1;KOX68243.1;KOX68729.1;KOX79039.1;KOX81395.1;KOX69814.1;KOX72105.1 Reactome: R-HSA-5358493 Synthesis of diphthamide-EEF2 5 KOX81155.1;KOX75297.1;KOX77844.1;KOX78480.1;KOX77355.1 KEGG: 04151+2.7.1.153 PI3K-Akt signaling pathway 1 KOX79243.1 Reactome: R-HSA-8964058 HDL remodeling 1 KOX79246.1 Reactome: R-HSA-8955332 Carboxyterminal post-translational modifications of tubulin 28 KOX71047.1;KOX79744.1;KOX72302.1;KOX72856.1;KOX75272.1;KOX68218.1;KOX79174.1;KOX72162.1;KOX70129.1;KOX76605.1;KOX78681.1;KOX69879.1;KOX72895.1;KOX75309.1;KOX68198.1;KOX77793.1;KOX72164.1;KOX72843.1;KOX71133.1;KOX72163.1;KOX71082.1;KOX72161.1;KOX68528.1;KOX80565.1;KOX77017.1;KOX69756.1;KOX77912.1;KOX70840.1 Reactome: R-HSA-9013507 NOTCH3 Activation and Transmission of Signal to the Nucleus 12 KOX67229.1;KOX77003.1;KOX69998.1;KOX70021.1;KOX79433.1;KOX68228.1;KOX72702.1;KOX77051.1;KOX79871.1;KOX72031.1;KOX79430.1;KOX72105.1 MetaCyc: PWY-3661 Glycine betaine degradation I 1 KOX69033.1 Reactome: R-HSA-2160456 Phenylketonuria 1 KOX77562.1 KEGG: 00770+3.6.1.9 Pantothenate and CoA biosynthesis 2 KOX69334.1;KOX80826.1 Reactome: R-HSA-75815 Ubiquitin-dependent degradation of Cyclin D 39 KOX70598.1;KOX68314.1;KOX72411.1;KOX78266.1;KOX76879.1;KOX79430.1;KOX73060.1;KOX76416.1;KOX67229.1;KOX70009.1;KOX76009.1;KOX80582.1;KOX71606.1;KOX78268.1;KOX72468.1;KOX73209.1;KOX74011.1;KOX79433.1;KOX74924.1;KOX74910.1;KOX75984.1;KOX79230.1;KOX72105.1;KOX70419.1;KOX79601.1;KOX70383.1;KOX68313.1;KOX78786.1;KOX72982.1;KOX79363.1;KOX77271.1;KOX75968.1;KOX70760.1;KOX80008.1;KOX79626.1;KOX69414.1;KOX78273.1;KOX69333.1;KOX68748.1 Reactome: R-HSA-77305 Beta oxidation of palmitoyl-CoA to myristoyl-CoA 1 KOX76405.1 MetaCyc: PWY-6992 1,5-anhydrofructose degradation 2 KOX74805.1;KOX67919.1 Reactome: R-HSA-196757 Metabolism of folate and pterines 9 KOX67514.1;KOX69033.1;KOX80540.1;KOX69389.1;KOX75639.1;KOX79374.1;KOX72989.1;KOX77269.1;KOX69388.1 MetaCyc: PWY-8053 Anandamide biosynthesis II 18 KOX70330.1;KOX77917.1;KOX69497.1;KOX77858.1;KOX80280.1;KOX75783.1;KOX78275.1;KOX75990.1;KOX69576.1;KOX72448.1;KOX67863.1;KOX79114.1;KOX67923.1;KOX78399.1;KOX76514.1;KOX79218.1;KOX80284.1;KOX78316.1 MetaCyc: PWY-5668 Cardiolipin biosynthesis I 2 KOX67809.1;KOX74437.1 KEGG: 00983+6.3.5.2 Drug metabolism - other enzymes 1 KOX80463.1 Reactome: R-HSA-1855204 Synthesis of IP3 and IP4 in the cytosol 7 KOX75330.1;KOX74178.1;KOX71582.1;KOX75106.1;KOX74989.1;KOX74728.1;KOX80873.1 Reactome: R-HSA-917729 Endosomal Sorting Complex Required For Transport (ESCRT) 14 KOX78305.1;KOX71636.1;KOX72105.1;KOX71483.1;KOX80074.1;KOX79430.1;KOX69076.1;KOX73877.1;KOX73678.1;KOX79433.1;KOX67716.1;KOX72168.1;KOX67229.1;KOX80787.1 Reactome: R-HSA-8853383 Lysosomal oligosaccharide catabolism 1 KOX74960.1 MetaCyc: PWY-5669 Phosphatidylserine and phosphatidylethanolamine biosynthesis I 1 KOX70005.1 Reactome: R-HSA-9617828 FOXO-mediated transcription of cell cycle genes 1 KOX72669.1 KEGG: 00510+3.2.1.106 N-Glycan biosynthesis 1 KOX72748.1 Reactome: R-HSA-4419969 Depolymerisation of the Nuclear Lamina 3 KOX67863.1;KOX81389.1;KOX71709.1 Reactome: R-HSA-72662 Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S 2 KOX69831.1;KOX68213.1 Reactome: R-HSA-5654706 FRS-mediated FGFR3 signaling 2 KOX67928.1;KOX81204.1 MetaCyc: PWY-5469 Sesamin biosynthesis 2 KOX77231.1;KOX69438.1 MetaCyc: PWY-7383 Anaerobic energy metabolism (invertebrates, cytosol) 11 KOX74975.1;KOX79794.1;KOX75374.1;KOX70050.1;KOX79912.1;KOX68928.1;KOX71428.1;KOX74974.1;KOX68597.1;KOX69541.1;KOX70049.1 Reactome: R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF 5 KOX68521.1;KOX79918.1;KOX68226.1;KOX68500.1;KOX80917.1 MetaCyc: PWY-3821 D-galactose detoxification 4 KOX67564.1;KOX72084.1;KOX68891.1;KOX77926.1 Reactome: R-HSA-3232118 SUMOylation of transcription factors 2 KOX75920.1;KOX79065.1 MetaCyc: PWY-621 Sucrose degradation III (sucrose invertase) 1 KOX67919.1 KEGG: 00270+1.1.1.37 Cysteine and methionine metabolism 5 KOX75374.1;KOX70050.1;KOX69541.1;KOX70049.1;KOX68928.1 Reactome: R-HSA-8986944 Transcriptional Regulation by MECP2 6 KOX70166.1;KOX70201.1;KOX74484.1;KOX74580.1;KOX67889.1;KOX68332.1 MetaCyc: PWY-7533 Gliotoxin biosynthesis 12 KOX70890.1;KOX71611.1;KOX67532.1;KOX69433.1;KOX71878.1;KOX74679.1;KOX81309.1;KOX71712.1;KOX70533.1;KOX71899.1;KOX70888.1;KOX76314.1 Reactome: R-HSA-6802953 RAS signaling downstream of NF1 loss-of-function variants 1 KOX74032.1 KEGG: 00280+4.2.1.17+1.1.1.35 Valine, leucine and isoleucine degradation 2 KOX76405.1;KOX75101.1 Reactome: R-HSA-1834941 STING mediated induction of host immune responses 1 KOX67371.1 Reactome: R-HSA-163210 Formation of ATP by chemiosmotic coupling 11 KOX77486.1;KOX78342.1;KOX74025.1;KOX77829.1;KOX70867.1;KOX80220.1;KOX79165.1;KOX78160.1;KOX73329.1;KOX79538.1;KOX72898.1 Reactome: R-HSA-212676 Dopamine Neurotransmitter Release Cycle 3 KOX74367.1;KOX74364.1;KOX75507.1 KEGG: 00930+3.1.1.17 Caprolactam degradation 1 KOX69067.1 KEGG: 00513+2.4.1.143 Various types of N-glycan biosynthesis 1 KOX79732.1 Reactome: R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins 9 KOX76684.1;KOX74256.1;KOX72749.1;KOX76210.1;KOX72154.1;KOX73267.1;KOX71992.1;KOX71898.1;KOX79389.1 Reactome: R-HSA-168315 Inhibition of Host mRNA Processing and RNA Silencing 1 KOX81159.1 KEGG: 00073+2.3.1.20 Cutin, suberine and wax biosynthesis 3 KOX78377.1;KOX77336.1;KOX72546.1 KEGG: 00520+4.2.1.47 Amino sugar and nucleotide sugar metabolism 1 KOX69413.1 MetaCyc: PWY-6121 5-aminoimidazole ribonucleotide biosynthesis I 3 KOX79954.1;KOX70064.1;KOX67689.1 MetaCyc: PWY-7205 CMP phosphorylation 4 KOX76865.1;KOX78158.1;KOX71458.1;KOX78412.1 MetaCyc: PWY-6610 Adenine salvage 1 KOX74349.1 Reactome: R-HSA-5683371 Defective ABCB6 causes isolated colobomatous microphthalmia 7 (MCOPCB7) 1 KOX74318.1 Reactome: R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 131 KOX77551.1;KOX72749.1;KOX74924.1;KOX74011.1;KOX67723.1;KOX73209.1;KOX70425.1;KOX72468.1;KOX71752.1;KOX67692.1;KOX80582.1;KOX70009.1;KOX76009.1;KOX72784.1;KOX67229.1;KOX69653.1;KOX76879.1;KOX68523.1;KOX68314.1;KOX72411.1;KOX72154.1;KOX70598.1;KOX73377.1;KOX68475.1;KOX69414.1;KOX80008.1;KOX73852.1;KOX81224.1;KOX77271.1;KOX67413.1;KOX72982.1;KOX75954.1;KOX70394.1;KOX70419.1;KOX80273.1;KOX74910.1;KOX75984.1;KOX76794.1;KOX78268.1;KOX73303.1;KOX76416.1;KOX76684.1;KOX72082.1;KOX76213.1;KOX67472.1;KOX68486.1;KOX75579.1;KOX74256.1;KOX71819.1;KOX75810.1;KOX78780.1;KOX75968.1;KOX69654.1;KOX77942.1;KOX76210.1;KOX81349.1;KOX70383.1;KOX72105.1;KOX68745.1;KOX73267.1;KOX73811.1;KOX77014.1;KOX69004.1;KOX71606.1;KOX70780.1;KOX77409.1;KOX71992.1;KOX74169.1;KOX68524.1;KOX79430.1;KOX72138.1;KOX68813.1;KOX80786.1;KOX77015.1;KOX69762.1;KOX78273.1;KOX79626.1;KOX77800.1;KOX75362.1;KOX67622.1;KOX77583.1;KOX80285.1;KOX78786.1;KOX78296.1;KOX69376.1;KOX79601.1;KOX71898.1;KOX79230.1;KOX68893.1;KOX72478.1;KOX75318.1;KOX77197.1;KOX69688.1;KOX79433.1;KOX68262.1;KOX68756.1;KOX77194.1;KOX73679.1;KOX73060.1;KOX79458.1;KOX79957.1;KOX80132.1;KOX78175.1;KOX74252.1;KOX73030.1;KOX69095.1;KOX78266.1;KOX71654.1;KOX72159.1;KOX79864.1;KOX69333.1;KOX68748.1;KOX67595.1;KOX76669.1;KOX75808.1;KOX79296.1;KOX67905.1;KOX77378.1;KOX70760.1;KOX75373.1;KOX78291.1;KOX77801.1;KOX68238.1;KOX68215.1;KOX78093.1;KOX79044.1;KOX79363.1;KOX68313.1;KOX75809.1;KOX71006.1;KOX73890.1 Reactome: R-HSA-5693579 Homologous DNA Pairing and Strand Exchange 16 KOX71763.1;KOX71786.1;KOX68858.1;KOX68054.1;KOX79196.1;KOX68243.1;KOX77923.1;KOX80977.1;KOX67721.1;KOX76598.1;KOX69173.1;KOX74812.1;KOX73599.1;KOX78861.1;KOX72024.1;KOX68669.1 Reactome: R-HSA-2206282 MPS IIIB - Sanfilippo syndrome B 1 KOX75831.1 KEGG: 00250+3.5.1.2 Alanine, aspartate and glutamate metabolism 1 KOX80357.1 KEGG: 00051+2.7.1.3 Fructose and mannose metabolism 1 KOX79350.1 KEGG: 00010+1.8.1.4 Glycolysis / Gluconeogenesis 1 KOX75086.1 Reactome: R-HSA-1482798 Acyl chain remodeling of CL 2 KOX76405.1;KOX77380.1 MetaCyc: PWY-5844 Menaquinol-9 biosynthesis 1 KOX75964.1 MetaCyc: PWY-5082 L-methionine degradation III 1 KOX67600.1 KEGG: 04926+2.7.11.1 Relaxin signaling pathway 40 KOX79039.1;KOX68566.1;KOX77803.1;KOX70561.1;KOX68521.1;KOX74479.1;KOX79033.1;KOX77506.1;KOX73800.1;KOX68654.1;KOX68084.1;KOX79166.1;KOX73362.1;KOX71595.1;KOX79522.1;KOX78362.1;KOX73724.1;KOX69619.1;KOX79817.1;KOX68054.1;KOX71579.1;KOX70861.1;KOX74186.1;KOX72201.1;KOX77898.1;KOX79675.1;KOX78509.1;KOX68647.1;KOX74477.1;KOX76214.1;KOX81246.1;KOX78841.1;KOX77364.1;KOX72400.1;KOX73463.1;KOX69995.1;KOX79225.1;KOX76221.1;KOX70676.1;KOX79935.1 Reactome: R-HSA-5696400 Dual Incision in GG-NER 30 KOX77830.1;KOX79548.1;KOX74923.1;KOX78024.1;KOX73785.1;KOX71193.1;KOX81364.1;KOX79433.1;KOX77356.1;KOX69897.1;KOX71452.1;KOX71969.1;KOX78784.1;KOX72105.1;KOX79430.1;KOX69540.1;KOX77633.1;KOX74030.1;KOX67310.1;KOX77326.1;KOX70402.1;KOX77276.1;KOX73285.1;KOX70388.1;KOX72417.1;KOX72862.1;KOX67229.1;KOX70673.1;KOX69719.1;KOX74919.1 Reactome: R-HSA-180585 Vif-mediated degradation of APOBEC3G 41 KOX75968.1;KOX70760.1;KOX80008.1;KOX79626.1;KOX69414.1;KOX78273.1;KOX68748.1;KOX69333.1;KOX79230.1;KOX70419.1;KOX72105.1;KOX79601.1;KOX70383.1;KOX78786.1;KOX68313.1;KOX72982.1;KOX79363.1;KOX77271.1;KOX67622.1;KOX80582.1;KOX71606.1;KOX72468.1;KOX78268.1;KOX73209.1;KOX74011.1;KOX79433.1;KOX74924.1;KOX75984.1;KOX74910.1;KOX70598.1;KOX72411.1;KOX68314.1;KOX79430.1;KOX78266.1;KOX76879.1;KOX72082.1;KOX67229.1;KOX76416.1;KOX73060.1;KOX76009.1;KOX70009.1 MetaCyc: PWY-6123 Inosine-5'-phosphate biosynthesis I 3 KOX67690.1;KOX71802.1;KOX71530.1 Reactome: R-HSA-72731 Recycling of eIF2:GDP 3 KOX70175.1;KOX72189.1;KOX70174.1 Reactome: R-HSA-427652 Sodium-coupled phosphate cotransporters 1 KOX78136.1 Reactome: R-HSA-5694530 Cargo concentration in the ER 5 KOX74767.1;KOX74595.1;KOX74490.1;KOX70581.1;KOX69869.1 Reactome: R-HSA-196843 Vitamin B2 (riboflavin) metabolism 2 KOX78122.1;KOX68033.1 Reactome: R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer 4 KOX72629.1;KOX70804.1;KOX81204.1;KOX73103.1 Reactome: R-HSA-936837 Ion transport by P-type ATPases 26 KOX72672.1;KOX71435.1;KOX71433.1;KOX72009.1;KOX79595.1;KOX71436.1;KOX68226.1;KOX77187.1;KOX71551.1;KOX76050.1;KOX76047.1;KOX71434.1;KOX75180.1;KOX73593.1;KOX80296.1;KOX77067.1;KOX69684.1;KOX79967.1;KOX72181.1;KOX71431.1;KOX76982.1;KOX71432.1;KOX74320.1;KOX80298.1;KOX70536.1;KOX75188.1 KEGG: 04070+2.7.1.107 Phosphatidylinositol signaling system 4 KOX79421.1;KOX73249.1;KOX68067.1;KOX76676.1 Reactome: R-HSA-5687128 MAPK6/MAPK4 signaling 49 KOX70760.1;KOX75968.1;KOX74580.1;KOX79626.1;KOX73517.1;KOX67889.1;KOX80008.1;KOX68332.1;KOX78273.1;KOX69414.1;KOX74139.1;KOX69333.1;KOX68748.1;KOX79230.1;KOX79601.1;KOX72105.1;KOX70419.1;KOX74165.1;KOX68313.1;KOX78786.1;KOX70383.1;KOX70201.1;KOX79363.1;KOX77271.1;KOX72982.1;KOX80582.1;KOX78779.1;KOX78268.1;KOX72468.1;KOX71606.1;KOX74011.1;KOX73209.1;KOX74910.1;KOX75984.1;KOX74924.1;KOX79433.1;KOX68314.1;KOX72411.1;KOX70598.1;KOX76879.1;KOX78266.1;KOX76191.1;KOX79430.1;KOX73060.1;KOX67229.1;KOX76416.1;KOX70009.1;KOX74484.1;KOX76009.1 Reactome: R-HSA-5173214 O-glycosylation of TSR domain-containing proteins 19 KOX70799.1;KOX67248.1;KOX72277.1;KOX75240.1;KOX70747.1;KOX68783.1;KOX79000.1;KOX70980.1;KOX72278.1;KOX80303.1;KOX75881.1;KOX72276.1;KOX70163.1;KOX70907.1;KOX71782.1;KOX75564.1;KOX67449.1;KOX71822.1;KOX76316.1 Reactome: R-HSA-9634638 Estrogen-dependent nuclear events downstream of ESR-membrane signaling 3 KOX72400.1;KOX70294.1;KOX68500.1 KEGG: 00362+4.2.1.17+1.1.1.35 Benzoate degradation 2 KOX75101.1;KOX76405.1 Reactome: R-HSA-447038 NrCAM interactions 1 KOX78706.1 KEGG: 00220+1.14.13.39 Arginine biosynthesis 1 KOX68681.1 Reactome: R-HSA-435368 Zinc efflux and compartmentalization by the SLC30 family 2 KOX67852.1;KOX79818.1 Reactome: R-HSA-8874081 MET activates PTK2 signaling 6 KOX75660.1;KOX75592.1;KOX74957.1;KOX78294.1;KOX71888.1;KOX75126.1 Reactome: R-HSA-4551638 SUMOylation of chromatin organization proteins 27 KOX74217.1;KOX77505.1;KOX73664.1;KOX77058.1;KOX73131.1;KOX67382.1;KOX74214.1;KOX75540.1;KOX68874.1;KOX75811.1;KOX81376.1;KOX79242.1;KOX75539.1;KOX72496.1;KOX77141.1;KOX72429.1;KOX77330.1;KOX79436.1;KOX80793.1;KOX75630.1;KOX78183.1;KOX68732.1;KOX73226.1;KOX80341.1;KOX69061.1;KOX72473.1;KOX68069.1 Reactome: R-HSA-4341670 Defective NEU1 causes sialidosis 1 KOX69240.1 MetaCyc: PWY-6945 Cholesterol degradation to androstenedione I (cholesterol oxidase) 2 KOX76405.1;KOX75101.1 Reactome: R-HSA-5655291 Signaling by FGFR4 in disease 1 KOX81204.1 KEGG: 00220+6.3.4.5 Arginine biosynthesis 1 KOX69117.1 Reactome: R-HSA-444821 Relaxin receptors 1 KOX79013.1 Reactome: R-HSA-8964041 LDL remodeling 5 KOX80996.1;KOX73997.1;KOX68248.1;KOX69335.1;KOX73976.1 KEGG: 00310+4.2.1.17+1.1.1.35 Lysine degradation 2 KOX76405.1;KOX75101.1 Reactome: R-HSA-182971 EGFR downregulation 9 KOX81204.1;KOX78779.1;KOX72105.1;KOX71483.1;KOX76191.1;KOX79430.1;KOX67229.1;KOX77118.1;KOX79433.1 KEGG: 00380+1.2.4.2 Tryptophan metabolism 3 KOX78238.1;KOX76981.1;KOX67894.1 Reactome: R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription 14 KOX74673.1;KOX79430.1;KOX72105.1;KOX79254.1;KOX67158.1;KOX72040.1;KOX71242.1;KOX74031.1;KOX67229.1;KOX79433.1;KOX69688.1;KOX76731.1;KOX69604.1;KOX69665.1 MetaCyc: PWY-801 Homocysteine and cysteine interconversion 1 KOX80071.1 Reactome: R-HSA-1237044 Erythrocytes take up carbon dioxide and release oxygen 4 KOX70001.1;KOX76686.1;KOX69472.1;KOX68616.1 Reactome: R-HSA-189483 Heme degradation 1 KOX70144.1 MetaCyc: PWY-6983 Threo-tetrahydrobiopterin biosynthesis 1 KOX73788.1 Reactome: R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 141 KOX76902.1;KOX76615.1;KOX77609.1;KOX68418.1;KOX68107.1;KOX75358.1;KOX73450.1;KOX78289.1;KOX67177.1;KOX68042.1;KOX74452.1;KOX73889.1;KOX77803.1;KOX71646.1;KOX78826.1;KOX76264.1;KOX67227.1;KOX69622.1;KOX79092.1;KOX73308.1;KOX67795.1;KOX71471.1;KOX75143.1;KOX68173.1;KOX71403.1;KOX70176.1;KOX75986.1;KOX70087.1;KOX77188.1;KOX67698.1;KOX67935.1;KOX79430.1;KOX78350.1;KOX72660.1;KOX74357.1;KOX80761.1;KOX75797.1;KOX79371.1;KOX75024.1;KOX72185.1;KOX76065.1;KOX71022.1;KOX68996.1;KOX74637.1;KOX77066.1;KOX71988.1;KOX68061.1;KOX73225.1;KOX74407.1;KOX69807.1;KOX79914.1;KOX68192.1;KOX72644.1;KOX77134.1;KOX68469.1;KOX70024.1;KOX78568.1;KOX76900.1;KOX79738.1;KOX79433.1;KOX70353.1;KOX71955.1;KOX75432.1;KOX67237.1;KOX72904.1;KOX68667.1;KOX67355.1;KOX68129.1;KOX71950.1;KOX77016.1;KOX78543.1;KOX73841.1;KOX78670.1;KOX68744.1;KOX70874.1;KOX78354.1;KOX78031.1;KOX74804.1;KOX74596.1;KOX74453.1;KOX77491.1;KOX70791.1;KOX78747.1;KOX73120.1;KOX69115.1;KOX67807.1;KOX68794.1;KOX75958.1;KOX68749.1;KOX72074.1;KOX69407.1;KOX71394.1;KOX74996.1;KOX69500.1;KOX78800.1;KOX70724.1;KOX79162.1;KOX67229.1;KOX67699.1;KOX72145.1;KOX78028.1;KOX75214.1;KOX79611.1;KOX72330.1;KOX70147.1;KOX67872.1;KOX81212.1;KOX76435.1;KOX81215.1;KOX67279.1;KOX71077.1;KOX75483.1;KOX73649.1;KOX72945.1;KOX77911.1;KOX79381.1;KOX67718.1;KOX68431.1;KOX81388.1;KOX78639.1;KOX74170.1;KOX67280.1;KOX74668.1;KOX73982.1;KOX72105.1;KOX76988.1;KOX67169.1;KOX70863.1;KOX78029.1;KOX72125.1;KOX75945.1;KOX76308.1;KOX68058.1;KOX79160.1;KOX76494.1;KOX73344.1;KOX67361.1;KOX75227.1;KOX71651.1;KOX80864.1;KOX79938.1 Reactome: R-HSA-8948216 Collagen chain trimerization 5 KOX75660.1;KOX74957.1;KOX75715.1;KOX76649.1;KOX75720.1 MetaCyc: PWY-8049 Pederin biosynthesis 2 KOX69550.1;KOX73549.1 Reactome: R-HSA-72764 Eukaryotic Translation Termination 81 KOX76900.1;KOX78568.1;KOX79433.1;KOX79738.1;KOX70024.1;KOX67237.1;KOX72904.1;KOX78457.1;KOX72125.1;KOX75945.1;KOX75432.1;KOX67361.1;KOX67731.1;KOX79160.1;KOX73344.1;KOX77016.1;KOX80864.1;KOX75227.1;KOX71651.1;KOX74357.1;KOX75797.1;KOX75024.1;KOX76065.1;KOX71077.1;KOX75483.1;KOX72185.1;KOX78350.1;KOX72660.1;KOX81215.1;KOX71988.1;KOX68431.1;KOX77911.1;KOX74637.1;KOX69807.1;KOX79914.1;KOX74170.1;KOX81388.1;KOX74407.1;KOX73982.1;KOX72105.1;KOX77134.1;KOX67280.1;KOX74668.1;KOX72644.1;KOX67807.1;KOX75958.1;KOX73308.1;KOX72074.1;KOX70724.1;KOX78800.1;KOX67795.1;KOX71471.1;KOX71394.1;KOX70176.1;KOX77188.1;KOX75143.1;KOX71403.1;KOX67229.1;KOX67699.1;KOX70147.1;KOX67698.1;KOX81212.1;KOX67935.1;KOX79430.1;KOX79611.1;KOX72330.1;KOX68744.1;KOX68107.1;KOX70874.1;KOX75358.1;KOX78670.1;KOX68042.1;KOX73450.1;KOX78289.1;KOX74804.1;KOX77319.1;KOX77318.1;KOX73889.1;KOX67227.1;KOX78826.1;KOX73120.1 KEGG: 00350+3.7.1.2 Tyrosine metabolism 1 KOX69218.1 Reactome: R-HSA-180746 Nuclear import of Rev protein 21 KOX72429.1;KOX75539.1;KOX75630.1;KOX79436.1;KOX80793.1;KOX80341.1;KOX73226.1;KOX68732.1;KOX78183.1;KOX72473.1;KOX69061.1;KOX73664.1;KOX77505.1;KOX73131.1;KOX77058.1;KOX75540.1;KOX79264.1;KOX79242.1;KOX68874.1;KOX75811.1;KOX81376.1 Reactome: R-HSA-182218 Nef Mediated CD8 Down-regulation 3 KOX68797.1;KOX76387.1;KOX69299.1 KEGG: 00053+1.1.1.22 Ascorbate and aldarate metabolism 1 KOX69806.1 KEGG: 00650+5.1.2.3+4.2.1.17+1.1.1.35 Butanoate metabolism 2 KOX76405.1;KOX75101.1 Reactome: R-HSA-5250924 B-WICH complex positively regulates rRNA expression 19 KOX77063.1;KOX71263.1;KOX72899.1;KOX77330.1;KOX73198.1;KOX70030.1;KOX81203.1;KOX77626.1;KOX68675.1;KOX67437.1;KOX74217.1;KOX77062.1;KOX72380.1;KOX75667.1;KOX74214.1;KOX68859.1;KOX67158.1;KOX81200.1;KOX79649.1 Reactome: R-HSA-5620912 Anchoring of the basal body to the plasma membrane 27 KOX73677.1;KOX80122.1;KOX75516.1;KOX75699.1;KOX67586.1;KOX79004.1;KOX71627.1;KOX78488.1;KOX73591.1;KOX75559.1;KOX69780.1;KOX79402.1;KOX70798.1;KOX67585.1;KOX68021.1;KOX72931.1;KOX76822.1;KOX73980.1;KOX71538.1;KOX76312.1;KOX75429.1;KOX75671.1;KOX69877.1;KOX71404.1;KOX69517.1;KOX73600.1;KOX72961.1 KEGG: 00270+2.6.1.42 Cysteine and methionine metabolism 1 KOX72274.1 MetaCyc: PWY-7199 Pyrimidine deoxyribonucleosides salvage 1 KOX71982.1 Reactome: R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization 2 KOX81204.1;KOX78362.1 Reactome: R-HSA-388479 Vasopressin-like receptors 2 KOX78636.1;KOX71639.1 Reactome: R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 23 KOX69604.1;KOX69665.1;KOX74031.1;KOX72040.1;KOX77003.1;KOX67229.1;KOX72334.1;KOX72105.1;KOX79430.1;KOX74673.1;KOX67619.1;KOX68228.1;KOX69688.1;KOX79433.1;KOX70021.1;KOX69998.1;KOX71242.1;KOX79254.1;KOX72031.1;KOX67158.1;KOX79871.1;KOX77051.1;KOX72702.1 Reactome: R-HSA-8935964 RUNX1 regulates expression of components of tight junctions 1 KOX79878.1 KEGG: 00280+2.6.1.42 Valine, leucine and isoleucine degradation 1 KOX72274.1 Reactome: R-HSA-427359 SIRT1 negatively regulates rRNA expression 5 KOX72380.1;KOX69176.1;KOX74217.1;KOX74214.1;KOX77330.1 Reactome: R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 7 KOX79430.1;KOX79433.1;KOX80313.1;KOX72105.1;KOX80312.1;KOX67229.1;KOX77358.1 Reactome: R-HSA-8939256 RUNX1 regulates transcription of genes involved in WNT signaling 1 KOX79878.1 KEGG: 00900+4.1.1.33 Terpenoid backbone biosynthesis 1 KOX69440.1 Reactome: R-HSA-428543 Inactivation of CDC42 and RAC1 2 KOX76191.1;KOX78779.1 MetaCyc: PWY-6281 L-selenocysteine biosynthesis II (archaea and eukaryotes) 5 KOX75283.1;KOX73295.1;KOX76367.1;KOX69204.1;KOX72747.1 Reactome: R-HSA-500753 Pyrimidine biosynthesis 3 KOX77918.1;KOX72385.1;KOX71473.1 Reactome: R-HSA-6807004 Negative regulation of MET activity 9 KOX67229.1;KOX69445.1;KOX79433.1;KOX77118.1;KOX75253.1;KOX81204.1;KOX79430.1;KOX71483.1;KOX72105.1 Reactome: R-HSA-190373 FGFR1c ligand binding and activation 1 KOX77425.1 KEGG: 00520+2.7.1.59 Amino sugar and nucleotide sugar metabolism 1 KOX72719.1 KEGG: 00561+3.2.1.22 Glycerolipid metabolism 1 KOX70065.1 Reactome: R-HSA-8949215 Mitochondrial calcium ion transport 8 KOX72916.1;KOX80851.1;KOX75686.1;KOX78018.1;KOX67995.1;KOX75281.1;KOX74583.1;KOX74585.1 KEGG: 00053+1.8.5.1 Ascorbate and aldarate metabolism 2 KOX69433.1;KOX71878.1 Reactome: R-HSA-4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1 4 KOX73118.1;KOX80364.1;KOX76492.1;KOX80363.1 MetaCyc: PWY-6837 Fatty acid beta-oxidation V (unsaturated, odd number, di-isomerase-dependent) 2 KOX71616.1;KOX73119.1 Reactome: R-HSA-450302 activated TAK1 mediates p38 MAPK activation 6 KOX75998.1;KOX72105.1;KOX79430.1;KOX79433.1;KOX73800.1;KOX67229.1 Reactome: R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling 9 KOX75489.1;KOX67229.1;KOX79229.1;KOX79433.1;KOX70261.1;KOX81261.1;KOX80344.1;KOX79430.1;KOX72105.1 Reactome: R-HSA-5619061 Defective SLC33A1 causes spastic paraplegia 42 (SPG42) 1 KOX80453.1 KEGG: 00052+3.5.1.25 Galactose metabolism 1 KOX77757.1 KEGG: 00254+6.4.1.2 Aflatoxin biosynthesis 1 KOX70011.1 Reactome: R-HSA-425986 Sodium/Proton exchangers 2 KOX78145.1;KOX81154.1 Reactome: R-HSA-5083629 Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 3 KOX70674.1;KOX71057.1;KOX80772.1 Reactome: R-HSA-5358346 Hedgehog ligand biogenesis 42 KOX69333.1;KOX68748.1;KOX75337.1;KOX69414.1;KOX78273.1;KOX80704.1;KOX80008.1;KOX79626.1;KOX75968.1;KOX70760.1;KOX72982.1;KOX77271.1;KOX79363.1;KOX70383.1;KOX68313.1;KOX78786.1;KOX72105.1;KOX70394.1;KOX70419.1;KOX79601.1;KOX79230.1;KOX79433.1;KOX74924.1;KOX74910.1;KOX75984.1;KOX73209.1;KOX74011.1;KOX71606.1;KOX78268.1;KOX72468.1;KOX80582.1;KOX70009.1;KOX76009.1;KOX73060.1;KOX67229.1;KOX76416.1;KOX76879.1;KOX78266.1;KOX79430.1;KOX70598.1;KOX68314.1;KOX72411.1 MetaCyc: PWY-7942 5-oxo-L-proline metabolism 3 KOX72668.1;KOX79873.1;KOX78388.1 Reactome: R-HSA-73980 RNA Polymerase III Transcription Termination 20 KOX77626.1;KOX79353.1;KOX70382.1;KOX77063.1;KOX72899.1;KOX73198.1;KOX81203.1;KOX77884.1;KOX67394.1;KOX79649.1;KOX81200.1;KOX74869.1;KOX68645.1;KOX77413.1;KOX77062.1;KOX74451.1;KOX67791.1;KOX68921.1;KOX76947.1;KOX71970.1 MetaCyc: PWY-5147 Oleate biosynthesis I (plants) 2 KOX69550.1;KOX73549.1 Reactome: R-HSA-3214858 RMTs methylate histone arginines 22 KOX72904.1;KOX71988.1;KOX69369.1;KOX74214.1;KOX76246.1;KOX73452.1;KOX75547.1;KOX74213.1;KOX81374.1;KOX73883.1;KOX72130.1;KOX74217.1;KOX74904.1;KOX73878.1;KOX77603.1;KOX79051.1;KOX77449.1;KOX76245.1;KOX77331.1;KOX77330.1;KOX67554.1;KOX75836.1 Reactome: R-HSA-5339716 Misspliced GSK3beta mutants stabilize beta-catenin 5 KOX75788.1;KOX69536.1;KOX71037.1;KOX76312.1;KOX73320.1 MetaCyc: PWY-7833 Biosynthesis of Lewis epitopes (H. pylori) 1 KOX67571.1 Reactome: R-HSA-4641257 Degradation of AXIN 42 KOX70197.1;KOX70760.1;KOX68742.1;KOX75968.1;KOX79626.1;KOX80008.1;KOX78273.1;KOX69414.1;KOX68748.1;KOX69333.1;KOX79230.1;KOX79601.1;KOX70419.1;KOX72105.1;KOX78786.1;KOX68313.1;KOX70383.1;KOX77271.1;KOX79363.1;KOX72982.1;KOX80582.1;KOX72468.1;KOX78268.1;KOX71606.1;KOX74011.1;KOX73209.1;KOX75984.1;KOX74910.1;KOX80121.1;KOX79433.1;KOX74924.1;KOX68314.1;KOX72411.1;KOX70598.1;KOX79430.1;KOX76879.1;KOX78266.1;KOX76416.1;KOX67229.1;KOX73060.1;KOX76009.1;KOX70009.1 KEGG: 00062+4.2.1.17+1.1.1.35 Fatty acid elongation 2 KOX76405.1;KOX75101.1 KEGG: 00240+2.4.2.10 Pyrimidine metabolism 1 KOX71473.1 KEGG: 00511+3.2.1.51 Other glycan degradation 1 KOX71867.1 Reactome: R-HSA-5637810 Constitutive Signaling by EGFRvIII 2 KOX73791.1;KOX81204.1 Reactome: R-HSA-162658 Golgi Cisternae Pericentriolar Stack Reorganization 4 KOX68500.1;KOX67706.1;KOX75219.1;KOX81327.1 Reactome: R-HSA-381771 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 7 KOX76114.1;KOX77642.1;KOX67929.1;KOX79467.1;KOX77641.1;KOX77868.1;KOX74243.1 Reactome: R-HSA-1358803 Downregulation of ERBB2:ERBB3 signaling 6 KOX78296.1;KOX67229.1;KOX79430.1;KOX79433.1;KOX72400.1;KOX72105.1 Reactome: R-HSA-8943724 Regulation of PTEN gene transcription 20 KOX70373.1;KOX73128.1;KOX78813.1;KOX68085.1;KOX68500.1;KOX73517.1;KOX68690.1;KOX77394.1;KOX68086.1;KOX73869.1;KOX73880.1;KOX80754.1;KOX73089.1;KOX72912.1;KOX78128.1;KOX79033.1;KOX74358.1;KOX72777.1;KOX68069.1;KOX67725.1 Reactome: R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants 5 KOX68500.1;KOX80917.1;KOX68226.1;KOX79918.1;KOX68521.1 Reactome: R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis 17 KOX77059.1;KOX69602.1;KOX77823.1;KOX70429.1;KOX69322.1;KOX76881.1;KOX67167.1;KOX76507.1;KOX76688.1;KOX67419.1;KOX81218.1;KOX76721.1;KOX71752.1;KOX77824.1;KOX78324.1;KOX74799.1;KOX70353.1 Reactome: R-HSA-2470946 Cohesin Loading onto Chromatin 6 KOX77869.1;KOX68193.1;KOX69625.1;KOX74954.1;KOX70177.1;KOX77396.1 KEGG: 00600+1.14.19.17 Sphingolipid metabolism 1 KOX76503.1 KEGG: 00650+4.2.1.17+1.1.1.35 Butanoate metabolism 2 KOX75101.1;KOX76405.1 Reactome: R-HSA-1227986 Signaling by ERBB2 2 KOX72629.1;KOX73791.1 KEGG: 00970+6.1.1.19 Aminoacyl-tRNA biosynthesis 1 KOX73972.1 MetaCyc: PWY-7921 Protein O-mannosylation I (yeast) 6 KOX71057.1;KOX72250.1;KOX70674.1;KOX72243.1;KOX81252.1;KOX77837.1 MetaCyc: PWY-7602 Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes) 21 KOX77795.1;KOX78654.1;KOX68696.1;KOX67350.1;KOX67486.1;KOX78650.1;KOX79701.1;KOX78662.1;KOX78657.1;KOX68278.1;KOX78653.1;KOX74597.1;KOX78236.1;KOX68279.1;KOX73201.1;KOX78713.1;KOX80068.1;KOX75202.1;KOX78659.1;KOX78660.1;KOX78651.1 Reactome: R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 9 KOX69536.1;KOX68500.1;KOX70804.1;KOX72629.1;KOX76312.1;KOX71037.1;KOX68497.1;KOX73103.1;KOX81204.1 Reactome: R-HSA-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 4 KOX80158.1;KOX75974.1;KOX68054.1;KOX75973.1 Reactome: R-HSA-964975 Vitamins B6 activation to pyridoxal phosphate 3 KOX80439.1;KOX70645.1;KOX67899.1 KEGG: 00600+3.1.3.4 Sphingolipid metabolism 2 KOX80284.1;KOX67863.1 Reactome: R-HSA-3214841 PKMTs methylate histone lysines 19 KOX70981.1;KOX74476.1;KOX73880.1;KOX74214.1;KOX74642.1;KOX79129.1;KOX78949.1;KOX67366.1;KOX74217.1;KOX68901.1;KOX68069.1;KOX79177.1;KOX76515.1;KOX69692.1;KOX67748.1;KOX73641.1;KOX72851.1;KOX75454.1;KOX77330.1 Reactome: R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 8 KOX79467.1;KOX74139.1;KOX73812.1;KOX78343.1;KOX76508.1;KOX71184.1;KOX69081.1;KOX79656.1 KEGG: 00240+3.6.1.6 Pyrimidine metabolism 1 KOX72820.1 MetaCyc: PWY-7996 Menaquinol-4 biosynthesis I 1 KOX75964.1 Reactome: R-HSA-9646399 Aggrephagy 23 KOX72161.1;KOX72105.1;KOX79430.1;KOX72163.1;KOX77793.1;KOX72164.1;KOX68198.1;KOX72843.1;KOX72021.1;KOX81224.1;KOX67229.1;KOX79174.1;KOX75272.1;KOX72302.1;KOX74322.1;KOX79744.1;KOX75211.1;KOX78693.1;KOX79433.1;KOX72895.1;KOX72162.1;KOX70129.1;KOX69879.1 MetaCyc: PWY-7663 Gondoate biosynthesis (anaerobic) 2 KOX73549.1;KOX69550.1 Reactome: R-HSA-2672351 Stimuli-sensing channels 25 KOX74465.1;KOX69683.1;KOX71676.1;KOX78818.1;KOX77685.1;KOX68790.1;KOX69845.1;KOX77990.1;KOX79433.1;KOX73079.1;KOX72105.1;KOX69520.1;KOX79430.1;KOX77398.1;KOX76000.1;KOX68687.1;KOX69844.1;KOX76867.1;KOX73585.1;KOX78314.1;KOX79606.1;KOX78817.1;KOX67229.1;KOX81276.1;KOX70034.1 Reactome: R-HSA-450513 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 12 KOX79092.1;KOX68794.1;KOX75605.1;KOX68192.1;KOX70791.1;KOX70145.1;KOX69500.1;KOX79938.1;KOX68469.1;KOX76988.1;KOX71022.1;KOX71950.1 Reactome: R-HSA-1912408 Pre-NOTCH Transcription and Translation 15 KOX80899.1;KOX69604.1;KOX70201.1;KOX74484.1;KOX69665.1;KOX71242.1;KOX77330.1;KOX74217.1;KOX67889.1;KOX68332.1;KOX74580.1;KOX73517.1;KOX67158.1;KOX74214.1;KOX69108.1 Reactome: R-HSA-388844 Receptor-type tyrosine-protein phosphatases 3 KOX68108.1;KOX74364.1;KOX74367.1 Reactome: R-HSA-3134975 Regulation of innate immune responses to cytosolic DNA 5 KOX67371.1;KOX72105.1;KOX79433.1;KOX79430.1;KOX67229.1 Reactome: R-HSA-1963642 PI3K events in ERBB2 signaling 2 KOX81204.1;KOX72629.1 Reactome: R-HSA-350562 Regulation of ornithine decarboxylase (ODC) 36 KOX79363.1;KOX77271.1;KOX72982.1;KOX68313.1;KOX78786.1;KOX70383.1;KOX79601.1;KOX68322.1;KOX70419.1;KOX79230.1;KOX69333.1;KOX68748.1;KOX78273.1;KOX69414.1;KOX79626.1;KOX80008.1;KOX70760.1;KOX75968.1;KOX70009.1;KOX76009.1;KOX73060.1;KOX76416.1;KOX76879.1;KOX78266.1;KOX72411.1;KOX68314.1;KOX70598.1;KOX74910.1;KOX75984.1;KOX74924.1;KOX74011.1;KOX73209.1;KOX78268.1;KOX72468.1;KOX71606.1;KOX80582.1 Reactome: R-HSA-9665249 Resistance of ERBB2 KD mutants to afatinib 1 KOX73791.1 MetaCyc: PWY-7039 Phosphatidate metabolism, as a signaling molecule 9 KOX79421.1;KOX75330.1;KOX74989.1;KOX74104.1;KOX71582.1;KOX76676.1;KOX68067.1;KOX74728.1;KOX73249.1 MetaCyc: PWY-601 Glucosinolate biosynthesis from tryptophan 1 KOX80071.1 Reactome: R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 23 KOX75539.1;KOX72429.1;KOX79436.1;KOX80793.1;KOX75630.1;KOX78183.1;KOX73083.1;KOX68732.1;KOX73226.1;KOX80341.1;KOX69061.1;KOX72473.1;KOX74908.1;KOX73664.1;KOX77505.1;KOX77058.1;KOX73131.1;KOX74909.1;KOX75540.1;KOX68874.1;KOX75811.1;KOX81376.1;KOX79242.1 KEGG: 00520+3.2.1.52 Amino sugar and nucleotide sugar metabolism 4 KOX74395.1;KOX74285.1;KOX73530.1;KOX74631.1 MetaCyc: PWY-1722 Formate assimilation into 5,10-methylenetetrahydrofolate 4 KOX67514.1;KOX77269.1;KOX69388.1;KOX69389.1 KEGG: 00310+2.1.1.60 Lysine degradation 1 KOX72173.1 KEGG: 00010+1.2.4.1 Glycolysis / Gluconeogenesis 4 KOX74119.1;KOX70042.1;KOX78471.1;KOX76243.1 KEGG: 00270+3.3.1.1 Cysteine and methionine metabolism 2 KOX70825.1;KOX73125.1 Reactome: R-HSA-2408550 Metabolism of ingested H2SeO4 and H2SeO3 into H2Se 2 KOX68057.1;KOX74601.1 MetaCyc: PWY-2201 Folate transformations I 6 KOX69033.1;KOX77269.1;KOX69389.1;KOX69388.1;KOX67514.1;KOX72989.1 MetaCyc: PWY-7250 [2Fe-2S] iron-sulfur cluster biosynthesis 1 KOX69261.1 KEGG: 00030+3.1.1.17 Pentose phosphate pathway 1 KOX69067.1 KEGG: 00520+5.4.2.3 Amino sugar and nucleotide sugar metabolism 1 KOX74440.1 MetaCyc: PWY-7746 Mycobacterial sulfolipid biosynthesis 2 KOX69550.1;KOX73549.1 MetaCyc: PWY-8040 Ansatrienin biosynthesis 1 KOX79794.1 Reactome: R-HSA-1483152 Hydrolysis of LPE 1 KOX71415.1 KEGG: 00350+1.13.11.5 Tyrosine metabolism 2 KOX80035.1;KOX80034.1 MetaCyc: PWY-7077 N-acetyl-D-galactosamine degradation 1 KOX77757.1 KEGG: 00900+2.1.1.100 Terpenoid backbone biosynthesis 1 KOX75593.1 Reactome: R-HSA-3371571 HSF1-dependent transactivation 4 KOX72777.1;KOX78813.1;KOX79033.1;KOX68226.1 KEGG: 00900+2.5.1.58 Terpenoid backbone biosynthesis 1 KOX79810.1 Reactome: R-HSA-176974 Unwinding of DNA 13 KOX72070.1;KOX76493.1;KOX69273.1;KOX80006.1;KOX68504.1;KOX68806.1;KOX67336.1;KOX75347.1;KOX69881.1;KOX70391.1;KOX70033.1;KOX74494.1;KOX73022.1 KEGG: 00720+4.2.1.17+1.1.1.35 Carbon fixation pathways in prokaryotes 2 KOX76405.1;KOX75101.1 KEGG: 00970+6.1.1.7 Aminoacyl-tRNA biosynthesis 2 KOX74438.1;KOX71748.1 MetaCyc: PWY-7220 Adenosine deoxyribonucleotides de novo biosynthesis II 5 KOX76865.1;KOX79885.1;KOX78158.1;KOX71458.1;KOX78412.1 Reactome: R-HSA-391908 Prostanoid ligand receptors 1 KOX78998.1 KEGG: 00290+4.2.1.33 Valine, leucine and isoleucine biosynthesis 2 KOX71536.1;KOX73090.1 KEGG: 00230+3.6.1.15 Purine metabolism 1 KOX74853.1 Reactome: R-HSA-5250971 Toxicity of botulinum toxin type C (BoNT/C) 1 KOX68427.1 Reactome: R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian gene expression 5 KOX76309.1;KOX78224.1;KOX68963.1;KOX74904.1;KOX78052.1 Reactome: R-HSA-177929 Signaling by EGFR 2 KOX72334.1;KOX67619.1 Reactome: R-HSA-450604 KSRP (KHSRP) binds and destabilizes mRNA 12 KOX70791.1;KOX70145.1;KOX68794.1;KOX79092.1;KOX77527.1;KOX68192.1;KOX71022.1;KOX71950.1;KOX69500.1;KOX79938.1;KOX68469.1;KOX76988.1 Reactome: R-HSA-5467340 AXIN missense mutants destabilize the destruction complex 5 KOX75788.1;KOX69536.1;KOX71037.1;KOX73320.1;KOX76312.1 Reactome: R-HSA-4615885 SUMOylation of DNA replication proteins 26 KOX80793.1;KOX79436.1;KOX75630.1;KOX75539.1;KOX72429.1;KOX76379.1;KOX69061.1;KOX79039.1;KOX71459.1;KOX72473.1;KOX78183.1;KOX80341.1;KOX73226.1;KOX68732.1;KOX69417.1;KOX77058.1;KOX73131.1;KOX73664.1;KOX77505.1;KOX80503.1;KOX81376.1;KOX68874.1;KOX75811.1;KOX79242.1;KOX78024.1;KOX75540.1 MetaCyc: PWY-5084 2-oxoglutarate decarboxylation to succinyl-CoA 5 KOX76981.1;KOX75086.1;KOX67894.1;KOX78238.1;KOX70384.1 Reactome: R-HSA-8941856 RUNX3 regulates NOTCH signaling 4 KOX69604.1;KOX67158.1;KOX69665.1;KOX71242.1 KEGG: 00062+4.2.1.134 Fatty acid elongation 2 KOX78236.1;KOX79701.1 KEGG: 00710+2.6.1.1 Carbon fixation in photosynthetic organisms 2 KOX79912.1;KOX71428.1 Reactome: R-HSA-2206292 MPS VII - Sly syndrome 1 KOX80383.1 KEGG: 00500+2.4.1.1 Starch and sucrose metabolism 1 KOX80377.1 KEGG: 00970+6.1.1.9 Aminoacyl-tRNA biosynthesis 2 KOX78428.1;KOX72472.1 MetaCyc: PWY-7277 Sphingolipid biosynthesis (mammals) 1 KOX68502.1 Reactome: R-HSA-3000170 Syndecan interactions 2 KOX70849.1;KOX73118.1 MetaCyc: PWY-3841 Folate transformations II (plants) 8 KOX67514.1;KOX71982.1;KOX69389.1;KOX80540.1;KOX69033.1;KOX72989.1;KOX69388.1;KOX77269.1 Reactome: R-HSA-1482801 Acyl chain remodelling of PS 5 KOX79218.1;KOX69576.1;KOX69497.1;KOX75783.1;KOX72448.1 KEGG: 00010+5.1.3.3 Glycolysis / Gluconeogenesis 1 KOX67206.1 MetaCyc: PWY-6362 1D-myo-inositol hexakisphosphate biosynthesis II (mammalian) 4 KOX80873.1;KOX81095.1;KOX69866.1;KOX81098.1 KEGG: 00052+5.1.3.2 Galactose metabolism 2 KOX72084.1;KOX77926.1 KEGG: 00970+6.1.1.10 Aminoacyl-tRNA biosynthesis 1 KOX69873.1 KEGG: 00020+4.2.1.2 Citrate cycle (TCA cycle) 1 KOX77859.1 MetaCyc: PWY-7269 NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast) 1 KOX79573.1 Reactome: R-HSA-9013700 NOTCH4 Activation and Transmission of Signal to the Nucleus 4 KOX68228.1;KOX69998.1;KOX70021.1;KOX77051.1 KEGG: 00051+4.2.1.68 Fructose and mannose metabolism 1 KOX74683.1 Reactome: R-HSA-1236394 Signaling by ERBB4 2 KOX68118.1;KOX67417.1 Reactome: R-HSA-69205 G1/S-Specific Transcription 13 KOX78024.1;KOX73662.1;KOX81352.1;KOX80540.1;KOX68519.1;KOX78132.1;KOX76415.1;KOX69890.1;KOX70054.1;KOX80899.1;KOX70592.1;KOX80006.1;KOX71982.1 KEGG: 00521+3.1.3.25 Streptomycin biosynthesis 3 KOX75546.1;KOX75545.1;KOX71857.1 MetaCyc: PWY-5366 Palmitoleate biosynthesis II (plants and bacteria) 2 KOX73549.1;KOX69550.1 Reactome: R-HSA-9616222 Transcriptional regulation of granulopoiesis 5 KOX80899.1;KOX74217.1;KOX79878.1;KOX74214.1;KOX77330.1 Reactome: R-HSA-8853884 Transcriptional Regulation by VENTX 12 KOX76684.1;KOX74256.1;KOX74484.1;KOX70201.1;KOX72749.1;KOX76210.1;KOX72154.1;KOX73267.1;KOX71992.1;KOX74580.1;KOX71898.1;KOX79389.1 Reactome: R-HSA-9648895 Response of EIF2AK1 (HRI) to heme deficiency 3 KOX70174.1;KOX69818.1;KOX70175.1 Reactome: R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C 47 KOX76009.1;KOX70009.1;KOX67229.1;KOX76416.1;KOX73060.1;KOX76684.1;KOX79430.1;KOX78266.1;KOX76879.1;KOX72154.1;KOX68314.1;KOX72411.1;KOX70598.1;KOX75984.1;KOX72749.1;KOX74910.1;KOX74924.1;KOX79433.1;KOX74011.1;KOX73209.1;KOX72468.1;KOX78268.1;KOX79389.1;KOX71606.1;KOX80582.1;KOX71992.1;KOX79363.1;KOX77271.1;KOX76210.1;KOX72982.1;KOX78786.1;KOX68313.1;KOX70383.1;KOX79601.1;KOX71898.1;KOX72105.1;KOX79230.1;KOX73267.1;KOX74256.1;KOX68748.1;KOX69333.1;KOX78273.1;KOX69414.1;KOX79626.1;KOX80008.1;KOX70760.1;KOX75968.1 KEGG: 00020+2.3.1.61 Citrate cycle (TCA cycle) 1 KOX70384.1 KEGG: 00280+1.3.8.4 Valine, leucine and isoleucine degradation 1 KOX67897.1 KEGG: 00240+3.6.1.23 Pyrimidine metabolism 1 KOX80533.1 MetaCyc: PWY-7724 Icosapentaenoate biosynthesis III (8-desaturase, mammals) 21 KOX77795.1;KOX78654.1;KOX68696.1;KOX67350.1;KOX67486.1;KOX78650.1;KOX78657.1;KOX78662.1;KOX79701.1;KOX78653.1;KOX68278.1;KOX74597.1;KOX78236.1;KOX78713.1;KOX68279.1;KOX73201.1;KOX80068.1;KOX78659.1;KOX75202.1;KOX78651.1;KOX78660.1 Reactome: R-HSA-139853 Elevation of cytosolic Ca2+ levels 1 KOX73812.1 KEGG: 00970+6.1.1.1 Aminoacyl-tRNA biosynthesis 1 KOX74595.1 Reactome: R-HSA-211976 Endogenous sterols 5 KOX77746.1;KOX74033.1;KOX67402.1;KOX76141.1;KOX80011.1 MetaCyc: PWY-4661 1D-myo-inositol hexakisphosphate biosynthesis III (Spirodela polyrrhiza) 4 KOX80873.1;KOX81095.1;KOX81098.1;KOX68055.1 Reactome: R-HSA-203615 eNOS activation 1 KOX69962.1 Reactome: R-HSA-432142 Platelet sensitization by LDL 8 KOX73976.1;KOX69536.1;KOX80996.1;KOX73997.1;KOX68248.1;KOX69335.1;KOX71037.1;KOX76312.1 MetaCyc: PWY-7409 Phospholipid remodeling (phosphatidylethanolamine, yeast) 10 KOX78399.1;KOX69497.1;KOX79218.1;KOX78316.1;KOX75783.1;KOX69576.1;KOX78275.1;KOX70330.1;KOX72448.1;KOX77917.1 Reactome: R-HSA-611105 Respiratory electron transport 63 KOX78137.1;KOX75738.1;KOX67192.1;KOX75291.1;KOX75544.1;KOX78655.1;KOX68793.1;KOX73387.1;KOX81074.1;KOX77876.1;KOX69912.1;KOX68680.1;KOX70297.1;KOX79257.1;KOX79963.1;KOX67705.1;KOX80989.1;KOX69215.1;KOX70326.1;KOX79795.1;KOX72664.1;KOX81326.1;KOX70788.1;KOX79416.1;KOX73143.1;KOX77849.1;KOX72878.1;KOX68532.1;KOX69501.1;KOX78094.1;KOX78629.1;KOX68679.1;KOX73350.1;KOX78567.1;KOX73051.1;KOX71023.1;KOX72809.1;KOX78801.1;KOX74653.1;KOX71883.1;KOX77397.1;KOX79955.1;KOX72006.1;KOX75846.1;KOX76310.1;KOX68112.1;KOX79348.1;KOX75491.1;KOX75228.1;KOX74760.1;KOX69910.1;KOX79413.1;KOX79547.1;KOX73731.1;KOX69086.1;KOX68433.1;KOX73142.1;KOX67584.1;KOX68416.1;KOX70714.1;KOX69899.1;KOX75223.1;KOX81235.1 MetaCyc: PWY-5049 Rosmarinic acid biosynthesis II 1 KOX71846.1 Reactome: R-HSA-6811555 PI5P Regulates TP53 Acetylation 2 KOX75489.1;KOX68237.1 Reactome: R-HSA-376176 Signaling by ROBO receptors 1 KOX79176.1 MetaCyc: PWY-7559 Glutathione degradation (DUG pathway 3 KOX79924.1;KOX71346.1;KOX78785.1 MetaCyc: PWY-7856 Heme a biosynthesis 1 KOX78502.1 Reactome: R-HSA-5578775 Ion homeostasis 7 KOX73585.1;KOX73812.1;KOX72009.1;KOX71030.1;KOX76050.1;KOX68226.1;KOX71026.1 MetaCyc: PWY-6842 Glutathione-mediated detoxification II 7 KOX71878.1;KOX79924.1;KOX80071.1;KOX69433.1;KOX71611.1;KOX71346.1;KOX78785.1 Reactome: R-HSA-3371599 Defective HLCS causes multiple carboxylase deficiency 4 KOX70011.1;KOX68340.1;KOX79449.1;KOX67840.1 MetaCyc: PWY-7664 Oleate biosynthesis IV (anaerobic) 2 KOX73549.1;KOX69550.1 MetaCyc: PWY-7858 (5Z)-dodecenoate biosynthesis II 4 KOX73119.1;KOX73549.1;KOX69550.1;KOX71616.1 KEGG: 00670+2.1.2.3 One carbon pool by folate 1 KOX71802.1 KEGG: 00983+1.17.3.2 Drug metabolism - other enzymes 1 KOX71781.1 Reactome: R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 18 KOX76508.1;KOX79656.1;KOX76688.1;KOX81218.1;KOX76721.1;KOX78343.1;KOX79369.1;KOX78324.1;KOX69322.1;KOX67335.1;KOX69081.1;KOX69602.1;KOX74177.1;KOX79467.1;KOX67167.1;KOX75383.1;KOX67385.1;KOX76507.1 Reactome: R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 2 KOX68497.1;KOX74914.1 KEGG: 00670+1.5.1.6 One carbon pool by folate 1 KOX75639.1 Reactome: R-HSA-913709 O-linked glycosylation of mucins 10 KOX68612.1;KOX71619.1;KOX71640.1;KOX70949.1;KOX72243.1;KOX68172.1;KOX70628.1;KOX68825.1;KOX77089.1;KOX69819.1 MetaCyc: PWY-6683 Assimilatory sulfate reduction III 2 KOX74601.1;KOX68057.1 KEGG: 00720+1.1.1.37 Carbon fixation pathways in prokaryotes 5 KOX75374.1;KOX70050.1;KOX68928.1;KOX70049.1;KOX69541.1 Reactome: R-HSA-9639288 Amino acids regulate mTORC1 38 KOX78128.1;KOX72760.1;KOX80793.1;KOX74244.1;KOX72418.1;KOX71614.1;KOX72777.1;KOX70637.1;KOX71792.1;KOX77357.1;KOX67725.1;KOX75953.1;KOX72144.1;KOX78813.1;KOX68085.1;KOX79728.1;KOX81297.1;KOX78290.1;KOX72912.1;KOX73089.1;KOX74358.1;KOX79033.1;KOX77098.1;KOX70575.1;KOX81298.1;KOX74155.1;KOX73127.1;KOX81219.1;KOX77058.1;KOX69852.1;KOX74829.1;KOX68086.1;KOX73541.1;KOX76903.1;KOX80754.1;KOX70126.1;KOX73869.1;KOX72903.1 MetaCyc: PWY-6277 Superpathway of 5-aminoimidazole ribonucleotide biosynthesis 3 KOX70064.1;KOX67689.1;KOX79954.1 MetaCyc: PWY-4202 Arsenate detoxification I (mammalian) 1 KOX78203.1 Reactome: R-HSA-8877330 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) 1 KOX79878.1 Reactome: R-HSA-2132295 MHC class II antigen presentation 47 KOX76344.1;KOX69240.1;KOX72161.1;KOX72163.1;KOX72164.1;KOX77793.1;KOX74123.1;KOX71404.1;KOX69299.1;KOX68241.1;KOX73197.1;KOX80782.1;KOX75989.1;KOX79174.1;KOX76387.1;KOX75272.1;KOX78032.1;KOX72302.1;KOX79744.1;KOX70995.1;KOX70569.1;KOX77058.1;KOX78693.1;KOX69879.1;KOX74219.1;KOX70875.1;KOX74490.1;KOX70129.1;KOX72162.1;KOX67147.1;KOX75429.1;KOX72843.1;KOX69877.1;KOX68198.1;KOX72021.1;KOX72183.1;KOX74595.1;KOX68797.1;KOX70581.1;KOX72663.1;KOX72900.1;KOX79827.1;KOX73888.1;KOX78534.1;KOX75211.1;KOX72469.1;KOX72895.1 Reactome: R-HSA-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes 5 KOX79430.1;KOX79433.1;KOX72105.1;KOX67229.1;KOX69032.1 Reactome: R-HSA-975144 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 5 KOX74906.1;KOX79430.1;KOX79433.1;KOX72105.1;KOX67229.1 MetaCyc: PWY-5972 Stearate biosynthesis I (animals) 19 KOX67486.1;KOX78650.1;KOX78662.1;KOX78657.1;KOX77795.1;KOX78654.1;KOX67350.1;KOX68696.1;KOX80068.1;KOX78659.1;KOX75202.1;KOX78660.1;KOX78651.1;KOX68278.1;KOX78653.1;KOX74597.1;KOX68279.1;KOX73201.1;KOX78713.1 MetaCyc: PWY-5691 Urate conversion to allantoin I 1 KOX78431.1 MetaCyc: PWY-6703 Preq0 biosynthesis 1 KOX73788.1 KEGG: 00600+2.4.1.80 Sphingolipid metabolism 1 KOX74918.1 KEGG: 00562+5.3.1.1 Inositol phosphate metabolism 1 KOX67171.1 Reactome: R-HSA-77346 Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA 1 KOX76405.1 KEGG: 00380+1.14.16.4 Tryptophan metabolism 1 KOX81148.1 KEGG: 00970+2.9.1.2 Aminoacyl-tRNA biosynthesis 1 KOX72747.1 Reactome: R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 2 KOX76722.1;KOX68945.1 KEGG: 00240+3.1.3.89 Pyrimidine metabolism 1 KOX73540.1 Reactome: R-HSA-75105 Fatty acyl-CoA biosynthesis 7 KOX74316.1;KOX76967.1;KOX73549.1;KOX72236.1;KOX69241.1;KOX75110.1;KOX69550.1 Reactome: R-HSA-975578 Reactions specific to the complex N-glycan synthesis pathway 2 KOX79732.1;KOX77864.1 Reactome: R-HSA-445095 Interaction between L1 and Ankyrins 4 KOX75027.1;KOX71756.1;KOX74949.1;KOX68791.1 MetaCyc: PWY-7222 Guanosine deoxyribonucleotides de novo biosynthesis II 5 KOX78158.1;KOX79885.1;KOX76865.1;KOX78412.1;KOX71458.1 Reactome: R-HSA-5693548 Sensing of DNA Double Strand Breaks 5 KOX74812.1;KOX68243.1;KOX80977.1;KOX68054.1;KOX71786.1 KEGG: 00230+1.1.1.205 Purine metabolism 1 KOX78850.1 Reactome: R-HSA-2022928 HS-GAG biosynthesis 11 KOX77892.1;KOX80363.1;KOX80364.1;KOX78012.1;KOX75430.1;KOX68966.1;KOX68737.1;KOX73118.1;KOX79992.1;KOX76492.1;KOX74836.1 KEGG: 00532+2.4.2.26 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 1 KOX79480.1 MetaCyc: PWY-6807 Xyloglucan degradation II (exoglucanase) 4 KOX71867.1;KOX77035.1;KOX75741.1;KOX80383.1 Reactome: R-HSA-1483166 Synthesis of PA 19 KOX69497.1;KOX77858.1;KOX80280.1;KOX75460.1;KOX74104.1;KOX75465.1;KOX78959.1;KOX75461.1;KOX76514.1;KOX79218.1;KOX68547.1;KOX67809.1;KOX79180.1;KOX75783.1;KOX75990.1;KOX69576.1;KOX72448.1;KOX79114.1;KOX67923.1 KEGG: 00520+3.5.99.6 Amino sugar and nucleotide sugar metabolism 2 KOX67942.1;KOX81368.1 Reactome: R-HSA-5633231 Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) 1 KOX74948.1 Reactome: R-HSA-77075 RNA Pol II CTD phosphorylation and interaction with CE 21 KOX77418.1;KOX79850.1;KOX67200.1;KOX70044.1;KOX74030.1;KOX76411.1;KOX69540.1;KOX78553.1;KOX77626.1;KOX81203.1;KOX73198.1;KOX74919.1;KOX69719.1;KOX77063.1;KOX79649.1;KOX72538.1;KOX73785.1;KOX74806.1;KOX81403.1;KOX77062.1;KOX69897.1 MetaCyc: PWY-181 Photorespiration 1 KOX69033.1 MetaCyc: PWY-6527 Stachyose degradation 6 KOX70065.1;KOX67374.1;KOX67564.1;KOX68891.1;KOX72084.1;KOX77926.1 Reactome: R-HSA-6783984 Glycine degradation 5 KOX68709.1;KOX79396.1;KOX69370.1;KOX75086.1;KOX69058.1 MetaCyc: PWY-3722 Glycine betaine biosynthesis II (Gram-positive bacteria) 4 KOX78880.1;KOX69462.1;KOX71151.1;KOX67667.1 KEGG: 00720+1.1.1.42 Carbon fixation pathways in prokaryotes 1 KOX79046.1 Reactome: R-HSA-437239 Recycling pathway of L1 18 KOX72895.1;KOX69879.1;KOX70129.1;KOX72162.1;KOX68797.1;KOX79174.1;KOX76387.1;KOX75272.1;KOX72302.1;KOX79744.1;KOX78841.1;KOX72161.1;KOX72163.1;KOX72843.1;KOX72164.1;KOX77793.1;KOX68198.1;KOX69299.1 Reactome: R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates 21 KOX76598.1;KOX80977.1;KOX67721.1;KOX78861.1;KOX72024.1;KOX69173.1;KOX74812.1;KOX73599.1;KOX76150.1;KOX68669.1;KOX71786.1;KOX68858.1;KOX68054.1;KOX71763.1;KOX80287.1;KOX79196.1;KOX68243.1;KOX76254.1;KOX70794.1;KOX77923.1;KOX67294.1 KEGG: 00280+4.2.1.17 Valine, leucine and isoleucine degradation 1 KOX76405.1 MetaCyc: PWY-7767 L-leucine degradation IV (Stickland reaction) 1 KOX72274.1 MetaCyc: PWY-6483 Ceramide degradation (generic) 2 KOX71112.1;KOX71109.1 Reactome: R-HSA-1483148 Synthesis of PG 5 KOX80981.1;KOX67809.1;KOX74437.1;KOX74104.1;KOX79180.1 Reactome: R-HSA-8876725 Protein methylation 8 KOX80940.1;KOX68070.1;KOX73536.1;KOX70297.1;KOX80570.1;KOX72904.1;KOX72173.1;KOX71988.1 KEGG: 00521+2.7.1.1 Streptomycin biosynthesis 2 KOX72065.1;KOX80688.1 KEGG: 00051+1.1.1.271 Fructose and mannose metabolism 1 KOX72980.1 Reactome: R-HSA-916853 Degradation of GABA 1 KOX75380.1 KEGG: 00020+6.4.1.1 Citrate cycle (TCA cycle) 1 KOX68340.1 KEGG: 00010+2.7.1.1 Glycolysis / Gluconeogenesis 2 KOX80688.1;KOX72065.1 KEGG: 00770+2.7.1.33 Pantothenate and CoA biosynthesis 3 KOX72290.1;KOX76985.1;KOX67569.1 Reactome: R-HSA-8983711 OAS antiviral response 1 KOX80002.1 Reactome: R-HSA-174113 SCF-beta-TrCP mediated degradation of Emi1 40 KOX70760.1;KOX75968.1;KOX79626.1;KOX80008.1;KOX78273.1;KOX69414.1;KOX69333.1;KOX68748.1;KOX79230.1;KOX79601.1;KOX72105.1;KOX70419.1;KOX68313.1;KOX78786.1;KOX70383.1;KOX77271.1;KOX79363.1;KOX72982.1;KOX80582.1;KOX78268.1;KOX72468.1;KOX71606.1;KOX74011.1;KOX73209.1;KOX74910.1;KOX75984.1;KOX74924.1;KOX69688.1;KOX79433.1;KOX68314.1;KOX72411.1;KOX70598.1;KOX76879.1;KOX78266.1;KOX79430.1;KOX73060.1;KOX76416.1;KOX67229.1;KOX70009.1;KOX76009.1 Reactome: R-HSA-5368286 Mitochondrial translation initiation 59 KOX72466.1;KOX70965.1;KOX79930.1;KOX68660.1;KOX70164.1;KOX74822.1;KOX78569.1;KOX74566.1;KOX75293.1;KOX77508.1;KOX75790.1;KOX77007.1;KOX75877.1;KOX80515.1;KOX68333.1;KOX68803.1;KOX78474.1;KOX74981.1;KOX79904.1;KOX71986.1;KOX73642.1;KOX73981.1;KOX75346.1;KOX71667.1;KOX71622.1;KOX79803.1;KOX67717.1;KOX74807.1;KOX80218.1;KOX77105.1;KOX81198.1;KOX75094.1;KOX67170.1;KOX75286.1;KOX77237.1;KOX71678.1;KOX79468.1;KOX79170.1;KOX69763.1;KOX71465.1;KOX67841.1;KOX77532.1;KOX71749.1;KOX74292.1;KOX78312.1;KOX77437.1;KOX70128.1;KOX73806.1;KOX77966.1;KOX81353.1;KOX72346.1;KOX77822.1;KOX79602.1;KOX70114.1;KOX68193.1;KOX79944.1;KOX78643.1;KOX70731.1;KOX77079.1 Reactome: R-HSA-418592 ADP signalling through P2Y purinoceptor 1 6 KOX79656.1;KOX67567.1;KOX69081.1;KOX78343.1;KOX79467.1;KOX76508.1 MetaCyc: PWY-8026 Sterol biosynthesis (methylotrophs) 1 KOX78838.1 KEGG: 00520+2.6.1.16 Amino sugar and nucleotide sugar metabolism 1 KOX68219.1 KEGG: 00640+6.2.1.1 Propanoate metabolism 1 KOX74892.1 KEGG: 00230+3.1.3.5 Purine metabolism 2 KOX75972.1;KOX75971.1 Reactome: R-HSA-5660862 Defective SLC7A7 causes lysinuric protein intolerance (LPI) 1 KOX71035.1 Reactome: R-HSA-3000497 Scavenging by Class H Receptors 5 KOX68248.1;KOX80996.1;KOX73997.1;KOX73976.1;KOX69335.1 Reactome: R-HSA-1474244 Extracellular matrix organization 2 KOX75720.1;KOX75715.1 MetaCyc: PWY-7185 UTP and CTP dephosphorylation I 5 KOX75972.1;KOX75971.1;KOX74853.1;KOX72820.1;KOX75796.1 Reactome: R-HSA-5205685 Pink/Parkin Mediated Mitophagy 11 KOX74882.1;KOX80344.1;KOX79430.1;KOX72105.1;KOX73643.1;KOX75279.1;KOX79208.1;KOX67229.1;KOX79229.1;KOX79433.1;KOX81224.1 Reactome: R-HSA-1362300 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 5 KOX80899.1;KOX70592.1;KOX70054.1;KOX73662.1;KOX68519.1 Reactome: R-HSA-181430 Norepinephrine Neurotransmitter Release Cycle 2 KOX74364.1;KOX74367.1 MetaCyc: PWY-5142 Acyl-[acyl-carrier protein] thioesterase pathway 2 KOX73549.1;KOX69550.1 MetaCyc: PWY-7177 UTP and CTP dephosphorylation II 1 KOX75796.1 Reactome: R-HSA-9609736 Assembly and cell surface presentation of NMDA receptors 18 KOX68537.1;KOX72162.1;KOX70129.1;KOX69879.1;KOX72895.1;KOX75272.1;KOX79174.1;KOX68226.1;KOX79744.1;KOX72302.1;KOX75507.1;KOX78706.1;KOX72163.1;KOX72161.1;KOX68198.1;KOX77793.1;KOX72164.1;KOX72843.1 Reactome: R-HSA-8875360 InlB-mediated entry of Listeria monocytogenes into host cell 7 KOX72105.1;KOX71483.1;KOX79433.1;KOX79430.1;KOX77118.1;KOX67229.1;KOX81204.1 Reactome: R-HSA-3322077 Glycogen synthesis 7 KOX67229.1;KOX67374.1;KOX72681.1;KOX79433.1;KOX79430.1;KOX68382.1;KOX72105.1 MetaCyc: PWY-7337 10-cis-heptadecenoyl-CoA degradation (yeast) 2 KOX73119.1;KOX71616.1 MetaCyc: PWY-6978 Plastoquinol-9 biosynthesis II 1 KOX77776.1 Reactome: R-HSA-1660661 Sphingolipid de novo biosynthesis 9 KOX81037.1;KOX70253.1;KOX76503.1;KOX76512.1;KOX68380.1;KOX67623.1;KOX68381.1;KOX72965.1;KOX68379.1 MetaCyc: PWY-5386 Methylglyoxal degradation I 2 KOX73783.1;KOX77340.1 Reactome: R-HSA-5689901 Metalloprotease DUBs 10 KOX79430.1;KOX80689.1;KOX80008.1;KOX72105.1;KOX71763.1;KOX67229.1;KOX79433.1;KOX72221.1;KOX68199.1;KOX68522.1 KEGG: 05235+3.1.3.16 PD-L1 expression and PD-1 checkpoint pathway in cancer 30 KOX67474.1;KOX72905.1;KOX81157.1;KOX74359.1;KOX71123.1;KOX73821.1;KOX75570.1;KOX74437.1;KOX78718.1;KOX71507.1;KOX73439.1;KOX79996.1;KOX69134.1;KOX80916.1;KOX70730.1;KOX68255.1;KOX78816.1;KOX75891.1;KOX76691.1;KOX71725.1;KOX78476.1;KOX68259.1;KOX68258.1;KOX68760.1;KOX74854.1;KOX74165.1;KOX72757.1;KOX72941.1;KOX69703.1;KOX71414.1 KEGG: 00564+1.1.1.94 Glycerophospholipid metabolism 3 KOX75460.1;KOX75461.1;KOX75465.1 MetaCyc: PWY-7395 D-galactosamine and N-acetyl-D-galactosamine degradation 1 KOX77757.1 MetaCyc: PWY-6609 Adenine and adenosine salvage III 2 KOX71685.1;KOX78203.1 MetaCyc: PWY-6074 Zymosterol biosynthesis 1 KOX78838.1 KEGG: 00920+2.7.7.4 Sulfur metabolism 2 KOX74601.1;KOX68057.1 Reactome: R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 15 KOX81203.1;KOX74806.1;KOX73198.1;KOX77062.1;KOX77063.1;KOX67774.1;KOX74908.1;KOX77418.1;KOX79649.1;KOX67200.1;KOX74311.1;KOX70831.1;KOX77626.1;KOX74909.1;KOX70044.1 MetaCyc: PWY-5057 L-valine degradation II 2 KOX72274.1;KOX67600.1 KEGG: 00627+4.2.1.17 Aminobenzoate degradation 2 KOX76405.1;KOX75101.1 KEGG: 00960+2.6.1.1 Tropane, piperidine and pyridine alkaloid biosynthesis 2 KOX79912.1;KOX71428.1 Reactome: R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript 31 KOX71506.1;KOX73785.1;KOX75987.1;KOX72538.1;KOX79649.1;KOX69897.1;KOX81403.1;KOX77062.1;KOX74806.1;KOX80159.1;KOX78553.1;KOX77626.1;KOX70044.1;KOX74030.1;KOX69540.1;KOX81395.1;KOX72082.1;KOX67200.1;KOX74945.1;KOX77418.1;KOX68573.1;KOX70730.1;KOX77063.1;KOX69424.1;KOX74919.1;KOX69719.1;KOX73198.1;KOX67622.1;KOX81203.1;KOX78696.1;KOX67799.1 Reactome: R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 93 KOX70874.1;KOX75358.1;KOX68744.1;KOX68107.1;KOX78670.1;KOX68042.1;KOX78289.1;KOX74804.1;KOX73450.1;KOX73889.1;KOX75967.1;KOX67227.1;KOX78826.1;KOX67969.1;KOX70175.1;KOX73120.1;KOX73308.1;KOX72074.1;KOX67807.1;KOX75958.1;KOX67810.1;KOX70724.1;KOX78800.1;KOX67795.1;KOX71471.1;KOX71394.1;KOX77188.1;KOX70176.1;KOX67699.1;KOX69831.1;KOX75143.1;KOX67229.1;KOX71403.1;KOX70147.1;KOX67698.1;KOX67935.1;KOX81212.1;KOX79430.1;KOX69171.1;KOX80902.1;KOX72330.1;KOX79611.1;KOX72185.1;KOX75483.1;KOX71077.1;KOX76065.1;KOX74357.1;KOX75797.1;KOX75024.1;KOX70174.1;KOX81215.1;KOX78350.1;KOX72660.1;KOX68431.1;KOX71988.1;KOX75064.1;KOX77911.1;KOX74637.1;KOX79914.1;KOX74170.1;KOX69807.1;KOX77634.1;KOX68213.1;KOX70202.1;KOX81388.1;KOX74407.1;KOX79833.1;KOX72105.1;KOX77134.1;KOX73982.1;KOX74668.1;KOX72644.1;KOX72470.1;KOX67280.1;KOX79738.1;KOX79433.1;KOX78568.1;KOX76900.1;KOX70024.1;KOX72904.1;KOX67237.1;KOX69593.1;KOX80758.1;KOX75432.1;KOX75945.1;KOX72125.1;KOX67361.1;KOX73344.1;KOX79160.1;KOX80864.1;KOX77016.1;KOX71651.1;KOX75227.1 Reactome: R-HSA-2022377 Metabolism of Angiotensinogen to Angiotensins 6 KOX75458.1;KOX67604.1;KOX69221.1;KOX71968.1;KOX80236.1;KOX80241.1 KEGG: 00604+3.2.1.23 Glycosphingolipid biosynthesis - ganglio series 3 KOX80383.1;KOX77035.1;KOX75741.1 Reactome: R-HSA-5083630 Defective LFNG causes SCDO3 1 KOX69108.1 MetaCyc: PWY-5104 L-isoleucine biosynthesis IV 1 KOX72274.1 KEGG: 00051+2.7.1.11 Fructose and mannose metabolism 1 KOX67867.1 MetaCyc: PWY-7154 Ergosterol biosynthesis II 1 KOX78838.1 MetaCyc: PWY-6908 Thiamine diphosphate biosynthesis IV (eukaryotes) 1 KOX78326.1 Reactome: R-HSA-3769402 Deactivation of the beta-catenin transactivating complex 13 KOX67626.1;KOX79433.1;KOX75788.1;KOX72153.1;KOX73320.1;KOX72851.1;KOX76731.1;KOX67229.1;KOX75454.1;KOX79430.1;KOX69586.1;KOX72105.1;KOX73641.1 MetaCyc: PWY-6606 Guanosine nucleotides degradation II 4 KOX75972.1;KOX71781.1;KOX73844.1;KOX75971.1 MetaCyc: PWY-6853 Ethylene biosynthesis II (microbes) 1 KOX67769.1 MetaCyc: PWY-8013 UDP-N-acetyl-D-galactosamine biosynthesis III 2 KOX68219.1;KOX67919.1 KEGG: 00901+2.7.1.222 Indole alkaloid biosynthesis 16 KOX77392.1;KOX79802.1;KOX69158.1;KOX69155.1;KOX69154.1;KOX67943.1;KOX75449.1;KOX79775.1;KOX76656.1;KOX79801.1;KOX74964.1;KOX69156.1;KOX69278.1;KOX79783.1;KOX80998.1;KOX76655.1 Reactome: R-HSA-2160916 Hyaluronan uptake and degradation 4 KOX74285.1;KOX80383.1;KOX74631.1;KOX73530.1 MetaCyc: PWY-7727 Docosahexaenoate biosynthesis IV (4-desaturase, mammals) 2 KOX79701.1;KOX78236.1 MetaCyc: PWY-6558 Heparan sulfate biosynthesis (late stages) 4 KOX74836.1;KOX68966.1;KOX78012.1;KOX77892.1 Reactome: R-HSA-912446 Meiotic recombination 19 KOX74214.1;KOX78861.1;KOX80977.1;KOX78256.1;KOX76315.1;KOX68669.1;KOX74217.1;KOX79196.1;KOX68243.1;KOX70402.1;KOX71763.1;KOX68054.1;KOX71786.1;KOX68858.1;KOX72417.1;KOX80229.1;KOX73170.1;KOX77330.1;KOX69898.1 MetaCyc: PWY-6611 Adenine and adenosine salvage V 2 KOX78203.1;KOX71685.1 Reactome: R-HSA-8951430 RUNX3 regulates WNT signaling 1 KOX67626.1 KEGG: 00564+1.1.5.3 Glycerophospholipid metabolism 1 KOX78959.1 Reactome: R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling 3 KOX68780.1;KOX73376.1;KOX70849.1 Reactome: R-HSA-211981 Xenobiotics 7 KOX69483.1;KOX78739.1;KOX72549.1;KOX68351.1;KOX68356.1;KOX67402.1;KOX76141.1 Reactome: R-HSA-390247 Beta-oxidation of very long chain fatty acids 1 KOX72779.1 KEGG: 00630+6.2.1.1 Glyoxylate and dicarboxylate metabolism 1 KOX74892.1 Reactome: R-HSA-264876 Insulin processing 8 KOX74557.1;KOX77029.1;KOX67727.1;KOX81399.1;KOX69758.1;KOX78763.1;KOX72399.1;KOX68808.1 Reactome: R-HSA-174437 Removal of the Flap Intermediate from the C-strand 8 KOX72417.1;KOX77356.1;KOX81364.1;KOX70179.1;KOX70402.1;KOX72024.1;KOX77326.1;KOX78024.1 KEGG: 00230+2.7.7.4 Purine metabolism 2 KOX68057.1;KOX74601.1 Reactome: R-HSA-5578749 Transcriptional regulation by small RNAs 32 KOX77062.1;KOX73664.1;KOX77505.1;KOX74217.1;KOX73131.1;KOX79264.1;KOX79649.1;KOX81376.1;KOX75811.1;KOX81203.1;KOX75630.1;KOX80793.1;KOX68732.1;KOX80341.1;KOX78183.1;KOX67200.1;KOX77058.1;KOX74214.1;KOX75540.1;KOX79242.1;KOX68874.1;KOX72429.1;KOX77330.1;KOX75539.1;KOX77063.1;KOX73198.1;KOX79436.1;KOX73226.1;KOX77626.1;KOX70044.1;KOX72473.1;KOX69061.1 MetaCyc: PWY-7036 Very long chain fatty acid biosynthesis II 21 KOX78654.1;KOX77795.1;KOX68696.1;KOX67350.1;KOX67486.1;KOX78657.1;KOX78662.1;KOX79701.1;KOX78650.1;KOX74597.1;KOX78653.1;KOX68278.1;KOX78713.1;KOX73201.1;KOX68279.1;KOX78236.1;KOX80068.1;KOX78660.1;KOX78651.1;KOX78659.1;KOX75202.1 MetaCyc: PWY-5353 Arachidonate biosynthesis I (6-desaturase, lower eukaryotes) 2 KOX78236.1;KOX79701.1 Reactome: R-HSA-2395516 Electron transport from NADPH to Ferredoxin 3 KOX74033.1;KOX80011.1;KOX77746.1 Reactome: R-HSA-1855231 Synthesis of IPs in the ER lumen 1 KOX68518.1 Reactome: R-HSA-1169408 ISG15 antiviral mechanism 29 KOX77058.1;KOX71677.1;KOX73131.1;KOX79433.1;KOX77505.1;KOX73664.1;KOX75489.1;KOX68874.1;KOX75811.1;KOX81376.1;KOX79459.1;KOX79242.1;KOX75540.1;KOX79436.1;KOX80793.1;KOX75630.1;KOX75539.1;KOX67229.1;KOX69831.1;KOX72429.1;KOX69061.1;KOX75105.1;KOX79430.1;KOX72473.1;KOX72105.1;KOX78183.1;KOX68732.1;KOX80341.1;KOX73226.1 MetaCyc: PWY-5642 2,4-dinitrotoluene degradation 1 KOX81134.1 Reactome: R-HSA-2022857 Keratan sulfate degradation 3 KOX74631.1;KOX73530.1;KOX74285.1 MetaCyc: PWY-5531 3,8-divinyl-chlorophyllide a biosynthesis II (anaerobic) 1 KOX75988.1 MetaCyc: PWY-5981 CDP-diacylglycerol biosynthesis III 9 KOX75461.1;KOX77858.1;KOX68030.1;KOX75460.1;KOX75990.1;KOX67877.1;KOX75465.1;KOX79114.1;KOX67923.1 Reactome: R-HSA-114604 GPVI-mediated activation cascade 5 KOX78779.1;KOX79097.1;KOX70804.1;KOX78362.1;KOX76191.1 MetaCyc: PWY-8106 Queuosine biosynthesis III (queuosine salvage) 2 KOX80753.1;KOX77698.1 KEGG: 00460+3.5.1.1 Cyanoamino acid metabolism 2 KOX71052.1;KOX72380.1 Reactome: R-HSA-68962 Activation of the pre-replicative complex 28 KOX81161.1;KOX77320.1;KOX72417.1;KOX71672.1;KOX78863.1;KOX76415.1;KOX80006.1;KOX70402.1;KOX77276.1;KOX67686.1;KOX74494.1;KOX73022.1;KOX79615.1;KOX76493.1;KOX69273.1;KOX71670.1;KOX81352.1;KOX70456.1;KOX78132.1;KOX72070.1;KOX79678.1;KOX69890.1;KOX68806.1;KOX77830.1;KOX70033.1;KOX70391.1;KOX73262.1;KOX69330.1 KEGG: 00790+3.1.3.1 Folate biosynthesis 4 KOX79580.1;KOX73014.1;KOX74128.1;KOX73008.1 MetaCyc: PWY-5067 Glycogen biosynthesis II (from UDP-D-Glucose) 3 KOX72681.1;KOX70625.1;KOX68382.1 KEGG: 00500+3.2.1.4 Starch and sucrose metabolism 1 KOX76353.1 KEGG: 00513+2.4.1.261 Various types of N-glycan biosynthesis 1 KOX76984.1 KEGG: 00760+6.3.1.5 Nicotinate and nicotinamide metabolism 1 KOX78680.1 KEGG: 00670+1.5.1.20 One carbon pool by folate 1 KOX72989.1 KEGG: 00510+2.4.1.143 N-Glycan biosynthesis 1 KOX79732.1 Reactome: R-HSA-156711 Polo-like kinase mediated events 3 KOX68519.1;KOX70592.1;KOX73662.1 KEGG: 00562+1.13.99.1 Inositol phosphate metabolism 1 KOX74115.1 MetaCyc: PWY-7656 Spodoptera littoralis pheromone biosynthesis 27 KOX77819.1;KOX76200.1;KOX80980.1;KOX76705.1;KOX74747.1;KOX68371.1;KOX68693.1;KOX72289.1;KOX75101.1;KOX76405.1;KOX67575.1;KOX70026.1;KOX72974.1;KOX67276.1;KOX70665.1;KOX76757.1;KOX67582.1;KOX67261.1;KOX68698.1;KOX68699.1;KOX67285.1;KOX70025.1;KOX75132.1;KOX67597.1;KOX74314.1;KOX67581.1;KOX67284.1 KEGG: 00052+5.1.3.3 Galactose metabolism 1 KOX67206.1 Reactome: R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC 5 KOX74595.1;KOX79365.1;KOX74490.1;KOX70581.1;KOX77058.1 KEGG: 00520+2.7.1.6 Amino sugar and nucleotide sugar metabolism 2 KOX67564.1;KOX68891.1 Reactome: R-HSA-2559585 Oncogene Induced Senescence 9 KOX79430.1;KOX72105.1;KOX74580.1;KOX79433.1;KOX80899.1;KOX74484.1;KOX70201.1;KOX68500.1;KOX67229.1 Reactome: R-HSA-3247509 Chromatin modifying enzymes 1 KOX75547.1 MetaCyc: PWY-3961 Phosphopantothenate biosynthesis II 3 KOX76985.1;KOX72290.1;KOX67569.1 KEGG: 00720+1.5.1.5+3.5.4.9 Carbon fixation pathways in prokaryotes 2 KOX67514.1;KOX77269.1 MetaCyc: PWY-7902 Glucosylglycerol biosynthesis 3 KOX75465.1;KOX75460.1;KOX75461.1 KEGG: 00270+2.5.1.16 Cysteine and methionine metabolism 2 KOX80905.1;KOX74762.1 Reactome: R-HSA-9665233 Resistance of ERBB2 KD mutants to trastuzumab 1 KOX73791.1 KEGG: 00280+1.2.1.27 Valine, leucine and isoleucine degradation 1 KOX81134.1 Reactome: R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network 25 KOX74480.1;KOX72178.1;KOX72450.1;KOX73246.1;KOX77238.1;KOX77544.1;KOX77702.1;KOX74577.1;KOX72831.1;KOX69808.1;KOX78216.1;KOX71647.1;KOX73107.1;KOX71890.1;KOX80114.1;KOX76079.1;KOX77542.1;KOX77559.1;KOX79167.1;KOX79043.1;KOX69822.1;KOX72348.1;KOX71889.1;KOX79005.1;KOX78763.1 KEGG: 00260+1.1.1.95 Glycine, serine and threonine metabolism 1 KOX74576.1 MetaCyc: PWY-7400 L-arginine biosynthesis IV (archaebacteria) 3 KOX69117.1;KOX81392.1;KOX80440.1 KEGG: 00030+3.1.3.11 Pentose phosphate pathway 1 KOX68814.1 Reactome: R-HSA-209560 NF-kB is activated and signals survival 5 KOX72105.1;KOX79433.1;KOX79430.1;KOX73643.1;KOX67229.1 MetaCyc: PWY-6364 D-myo-inositol (1,3,4)-trisphosphate biosynthesis 1 KOX69866.1 Reactome: R-HSA-9617324 Negative regulation of NMDA receptor-mediated neuronal transmission 3 KOX78706.1;KOX68226.1;KOX68537.1 MetaCyc: PWY-5109 Fermentation to 2-methylbutanoate 2 KOX76405.1;KOX75101.1 Reactome: R-HSA-8878166 Transcriptional regulation by RUNX2 2 KOX79878.1;KOX73376.1 Reactome: R-HSA-167242 Abortive elongation of HIV-1 transcript in the absence of Tat 19 KOX70044.1;KOX77626.1;KOX78553.1;KOX67200.1;KOX77418.1;KOX74945.1;KOX68573.1;KOX77063.1;KOX70730.1;KOX69424.1;KOX73198.1;KOX81203.1;KOX74909.1;KOX71506.1;KOX79649.1;KOX74908.1;KOX77062.1;KOX80159.1;KOX74806.1 KEGG: 00230+2.7.4.3 Purine metabolism 8 KOX77775.1;KOX73294.1;KOX76788.1;KOX71192.1;KOX78323.1;KOX78710.1;KOX79001.1;KOX80742.1 KEGG: 00970+6.1.1.22 Aminoacyl-tRNA biosynthesis 2 KOX76891.1;KOX70869.1 Reactome: R-HSA-2660826 Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant 4 KOX67619.1;KOX72334.1;KOX77003.1;KOX79871.1 Reactome: R-HSA-198753 ERK/MAPK targets 2 KOX68500.1;KOX76312.1 Reactome: R-HSA-425410 Metal ion SLC transporters 2 KOX74328.1;KOX74327.1 Reactome: R-HSA-8854691 Interleukin-20 family signaling 1 KOX79805.1 KEGG: 00020+1.2.4.2 Citrate cycle (TCA cycle) 3 KOX78238.1;KOX67894.1;KOX76981.1 Reactome: R-HSA-9028335 Activated NTRK2 signals through PI3K 1 KOX81204.1 MetaCyc: PWY-7783 Plasmalogen degradation 10 KOX75783.1;KOX69576.1;KOX78275.1;KOX70330.1;KOX72448.1;KOX77917.1;KOX78399.1;KOX69497.1;KOX79218.1;KOX78316.1 Reactome: R-HSA-2024096 HS-GAG degradation 10 KOX73118.1;KOX72773.1;KOX81256.1;KOX80364.1;KOX80363.1;KOX80277.1;KOX75831.1;KOX80589.1;KOX76492.1;KOX80383.1 Reactome: R-HSA-381340 Transcriptional regulation of white adipocyte differentiation 35 KOX76309.1;KOX71620.1;KOX70293.1;KOX75722.1;KOX74616.1;KOX69665.1;KOX75721.1;KOX79974.1;KOX70422.1;KOX70063.1;KOX71407.1;KOX80339.1;KOX74904.1;KOX78565.1;KOX68963.1;KOX68771.1;KOX68229.1;KOX77181.1;KOX79845.1;KOX71552.1;KOX70259.1;KOX72755.1;KOX78052.1;KOX74632.1;KOX71879.1;KOX74031.1;KOX67461.1;KOX70975.1;KOX68772.1;KOX79676.1;KOX72486.1;KOX76194.1;KOX80746.1;KOX75944.1;KOX72224.1 Reactome: R-HSA-110330 Recognition and association of DNA glycosylase with site containing an affected purine 5 KOX67788.1;KOX74217.1;KOX70328.1;KOX77330.1;KOX74214.1 KEGG: 00061+6.4.1.2 Fatty acid biosynthesis 1 KOX70011.1 Reactome: R-HSA-5620922 BBSome-mediated cargo-targeting to cilium 11 KOX74485.1;KOX76721.1;KOX68621.1;KOX71091.1;KOX76688.1;KOX81218.1;KOX76381.1;KOX73847.1;KOX72146.1;KOX74449.1;KOX76507.1 Reactome: R-HSA-264870 Caspase-mediated cleavage of cytoskeletal proteins 1 KOX78201.1 MetaCyc: PWY-6174 Mevalonate pathway II (archaea) 2 KOX74855.1;KOX70405.1 Reactome: R-HSA-5223345 Miscellaneous transport and binding events 3 KOX72203.1;KOX78787.1;KOX78643.1 Reactome: R-HSA-2871809 FCERI mediated Ca+2 mobilization 4 KOX73812.1;KOX81204.1;KOX79097.1;KOX71582.1 Reactome: R-HSA-351202 Metabolism of polyamines 4 KOX68063.1;KOX80905.1;KOX74762.1;KOX68062.1 Reactome: R-HSA-5610783 Degradation of GLI2 by the proteasome 42 KOX75968.1;KOX70760.1;KOX72837.1;KOX80008.1;KOX79626.1;KOX69414.1;KOX74139.1;KOX78273.1;KOX69333.1;KOX68748.1;KOX79230.1;KOX72105.1;KOX70419.1;KOX79601.1;KOX70383.1;KOX68313.1;KOX78786.1;KOX72982.1;KOX77271.1;KOX79363.1;KOX80582.1;KOX71606.1;KOX78268.1;KOX72468.1;KOX73209.1;KOX74011.1;KOX69688.1;KOX74924.1;KOX79433.1;KOX74910.1;KOX75984.1;KOX70598.1;KOX68314.1;KOX72411.1;KOX78266.1;KOX76879.1;KOX79430.1;KOX73060.1;KOX67229.1;KOX76416.1;KOX70009.1;KOX76009.1 KEGG: 00670+2.1.2.1 One carbon pool by folate 1 KOX69033.1 KEGG: 00280+2.3.3.10 Valine, leucine and isoleucine degradation 1 KOX70405.1 KEGG: 00680+2.7.1.11 Methane metabolism 1 KOX67867.1 Reactome: R-HSA-196807 Nicotinate metabolism 5 KOX78680.1;KOX79573.1;KOX80677.1;KOX79553.1;KOX79554.1 KEGG: 00330+2.6.1.1 Arginine and proline metabolism 2 KOX71428.1;KOX79912.1 MetaCyc: PWY-7410 Ipsdienol biosynthesis 1 KOX72808.1 MetaCyc: PWY-6898 Thiamine salvage III 1 KOX78326.1 KEGG: 00010+1.2.1.12 Glycolysis / Gluconeogenesis 1 KOX72508.1 Reactome: R-HSA-5654712 FRS-mediated FGFR4 signaling 2 KOX81204.1;KOX67928.1 KEGG: 00010+5.3.1.1 Glycolysis / Gluconeogenesis 1 KOX67171.1 Reactome: R-HSA-3000171 Non-integrin membrane-ECM interactions 10 KOX78294.1;KOX75660.1;KOX74957.1;KOX80772.1;KOX75592.1;KOX75126.1;KOX71888.1;KOX75720.1;KOX78431.1;KOX75715.1 MetaCyc: PWY-7234 Inosine-5'-phosphate biosynthesis III 3 KOX71530.1;KOX71802.1;KOX67690.1 Reactome: R-HSA-5218920 VEGFR2 mediated vascular permeability 7 KOX72400.1;KOX78813.1;KOX79033.1;KOX80436.1;KOX72981.1;KOX78362.1;KOX79097.1 Reactome: R-HSA-180292 GAB1 signalosome 1 KOX81204.1 MetaCyc: PWY-6679 Jadomycin biosynthesis 1 KOX70011.1 MetaCyc: PWY-6012-1 Acyl carrier protein activation 1 KOX75794.1 KEGG: 00020+4.1.1.32 Citrate cycle (TCA cycle) 1 KOX68597.1 KEGG: 00240+4.2.1.70 Pyrimidine metabolism 1 KOX78235.1 KEGG: 00480+6.3.2.2 Glutathione metabolism 1 KOX78147.1 Reactome: R-HSA-165159 mTOR signalling 12 KOX74358.1;KOX68085.1;KOX78813.1;KOX79033.1;KOX72777.1;KOX73089.1;KOX72912.1;KOX78128.1;KOX73869.1;KOX67725.1;KOX80754.1;KOX68086.1 Reactome: R-HSA-68949 Orc1 removal from chromatin 55 KOX72411.1;KOX68314.1;KOX70598.1;KOX78266.1;KOX76879.1;KOX67686.1;KOX79430.1;KOX73060.1;KOX76416.1;KOX67229.1;KOX70009.1;KOX76009.1;KOX80582.1;KOX68806.1;KOX78268.1;KOX70033.1;KOX72468.1;KOX71606.1;KOX70456.1;KOX74011.1;KOX72070.1;KOX73209.1;KOX79615.1;KOX81352.1;KOX74910.1;KOX75984.1;KOX69890.1;KOX79433.1;KOX69688.1;KOX74924.1;KOX79230.1;KOX74494.1;KOX73022.1;KOX79601.1;KOX72105.1;KOX70419.1;KOX68313.1;KOX78786.1;KOX70383.1;KOX79363.1;KOX77271.1;KOX76415.1;KOX72982.1;KOX70760.1;KOX75968.1;KOX73262.1;KOX70391.1;KOX79626.1;KOX80008.1;KOX78273.1;KOX76493.1;KOX69273.1;KOX69414.1;KOX69333.1;KOX68748.1 KEGG: 00270+6.3.2.3 Cysteine and methionine metabolism 1 KOX76540.1 KEGG: 00270+1.13.11.20 Cysteine and methionine metabolism 1 KOX69327.1 Reactome: R-HSA-442742 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 1 KOX78841.1 Reactome: R-HSA-73843 5-Phosphoribose 1-diphosphate biosynthesis 1 KOX69375.1 KEGG: 00720+4.2.1.17 Carbon fixation pathways in prokaryotes 1 KOX76405.1 KEGG: 00030+5.3.1.9 Pentose phosphate pathway 1 KOX67919.1 KEGG: 00062+3.1.2.22 Fatty acid elongation 1 KOX72236.1 Reactome: R-HSA-419037 NCAM1 interactions 3 KOX75715.1;KOX75720.1;KOX69225.1 MetaCyc: PWY-7782 Plasmalogen biosynthesis 33 KOX76757.1;KOX70665.1;KOX67276.1;KOX72974.1;KOX67582.1;KOX74747.1;KOX72289.1;KOX77819.1;KOX67581.1;KOX70025.1;KOX75132.1;KOX67597.1;KOX67923.1;KOX79114.1;KOX68699.1;KOX67285.1;KOX80284.1;KOX68698.1;KOX67261.1;KOX67575.1;KOX70026.1;KOX77488.1;KOX77858.1;KOX68371.1;KOX68693.1;KOX76200.1;KOX76705.1;KOX80980.1;KOX75990.1;KOX67284.1;KOX67863.1;KOX74314.1;KOX67207.1 Reactome: R-HSA-211945 Phase I - Functionalization of compounds 3 KOX76141.1;KOX67402.1;KOX80372.1 Reactome: R-HSA-2564830 Cytosolic iron-sulfur cluster assembly 8 KOX71780.1;KOX72292.1;KOX72293.1;KOX71474.1;KOX73785.1;KOX78522.1;KOX67941.1;KOX81400.1 Reactome: R-HSA-1234158 Regulation of gene expression by Hypoxia-inducible Factor 1 KOX69665.1 Reactome: R-HSA-5389840 Mitochondrial translation elongation 61 KOX75346.1;KOX71667.1;KOX73981.1;KOX71986.1;KOX73642.1;KOX77105.1;KOX81198.1;KOX71622.1;KOX74807.1;KOX79803.1;KOX67717.1;KOX80218.1;KOX70854.1;KOX76419.1;KOX79263.1;KOX78569.1;KOX74822.1;KOX68660.1;KOX79930.1;KOX70965.1;KOX72466.1;KOX79904.1;KOX78474.1;KOX74981.1;KOX68803.1;KOX77007.1;KOX80515.1;KOX75877.1;KOX68333.1;KOX74566.1;KOX75293.1;KOX75790.1;KOX77508.1;KOX72346.1;KOX81353.1;KOX77966.1;KOX79944.1;KOX70731.1;KOX78643.1;KOX77079.1;KOX70114.1;KOX68193.1;KOX77822.1;KOX79602.1;KOX67841.1;KOX77532.1;KOX71749.1;KOX71465.1;KOX79468.1;KOX79170.1;KOX69763.1;KOX67170.1;KOX75286.1;KOX75094.1;KOX77237.1;KOX71678.1;KOX73806.1;KOX70128.1;KOX78312.1;KOX77437.1;KOX74292.1 MetaCyc: PWY-4983 Nitric oxide biosynthesis II (mammals) 3 KOX81392.1;KOX69117.1;KOX68681.1 Reactome: R-HSA-8856828 Clathrin-mediated endocytosis 33 KOX72015.1;KOX72186.1;KOX76387.1;KOX76332.1;KOX67192.1;KOX67522.1;KOX74184.1;KOX69299.1;KOX71483.1;KOX72105.1;KOX67917.1;KOX68066.1;KOX68248.1;KOX72406.1;KOX74872.1;KOX80996.1;KOX77118.1;KOX78385.1;KOX73246.1;KOX69335.1;KOX68797.1;KOX73976.1;KOX74577.1;KOX73997.1;KOX79433.1;KOX81204.1;KOX79430.1;KOX79055.1;KOX67229.1;KOX76831.1;KOX74764.1;KOX74178.1;KOX80893.1 MetaCyc: PWY-6147 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I 1 KOX73788.1 KEGG: 00280+4.1.3.4 Valine, leucine and isoleucine degradation 1 KOX72741.1 KEGG: 00510+3.6.1.43 N-Glycan biosynthesis 1 KOX81237.1 MetaCyc: PWY-3162 L-tryptophan degradation V (side chain pathway) 1 KOX67600.1 KEGG: 00260+2.3.1.37 Glycine, serine and threonine metabolism 1 KOX74171.1 KEGG: 00680+3.1.3.3 Methane metabolism 1 KOX78490.1 KEGG: 00562+3.1.3.56 Inositol phosphate metabolism 1 KOX69866.1 Reactome: R-HSA-425366 Transport of bile salts and organic acids, metal ions and amine compounds 4 KOX78075.1;KOX74496.1;KOX69985.1;KOX74495.1 MetaCyc: PWY-6030 Serotonin and melatonin biosynthesis 1 KOX81148.1 Reactome: R-HSA-8948747 Regulation of PTEN localization 5 KOX69032.1;KOX67229.1;KOX72105.1;KOX79430.1;KOX79433.1 Reactome: R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis 21 KOX79199.1;KOX78982.1;KOX70356.1;KOX70968.1;KOX68963.1;KOX70204.1;KOX74904.1;KOX68120.1;KOX78465.1;KOX70690.1;KOX67775.1;KOX68053.1;KOX76309.1;KOX69899.1;KOX78052.1;KOX78094.1;KOX79538.1;KOX70971.1;KOX70325.1;KOX69910.1;KOX79624.1 MetaCyc: PWY-5381 Pyridine nucleotide cycling (plants) 5 KOX80677.1;KOX78680.1;KOX75971.1;KOX75972.1;KOX78224.1 Reactome: R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 26 KOX78129.1;KOX75429.1;KOX69877.1;KOX71404.1;KOX76312.1;KOX73600.1;KOX79428.1;KOX78158.1;KOX77754.1;KOX68936.1;KOX78488.1;KOX79004.1;KOX73591.1;KOX75559.1;KOX69780.1;KOX79233.1;KOX75516.1;KOX75699.1;KOX71287.1;KOX80122.1;KOX79985.1;KOX72895.1;KOX70798.1;KOX68021.1;KOX76822.1;KOX72931.1 KEGG: 00051+5.4.2.8 Fructose and mannose metabolism 1 KOX72772.1 KEGG: 00562+2.7.8.11 Inositol phosphate metabolism 1 KOX76348.1 Reactome: R-HSA-77348 Beta oxidation of octanoyl-CoA to hexanoyl-CoA 1 KOX76405.1 MetaCyc: PWY-7356 Thiamine salvage IV (yeast) 1 KOX78326.1 KEGG: 00330+4.1.1.50 Arginine and proline metabolism 2 KOX68062.1;KOX68063.1 Reactome: R-HSA-72086 mRNA Capping 23 KOX81203.1;KOX73198.1;KOX69719.1;KOX74919.1;KOX77063.1;KOX77418.1;KOX79850.1;KOX67200.1;KOX70044.1;KOX69540.1;KOX74030.1;KOX76411.1;KOX78553.1;KOX77626.1;KOX74806.1;KOX77062.1;KOX81403.1;KOX69897.1;KOX74908.1;KOX79649.1;KOX72538.1;KOX74909.1;KOX73785.1 MetaCyc: PWY-5041 S-adenosyl-L-methionine cycle II 3 KOX77579.1;KOX73125.1;KOX70825.1 Reactome: R-HSA-8953750 Transcriptional Regulation by E2F6 10 KOX73880.1;KOX78861.1;KOX68069.1;KOX71763.1;KOX74615.1;KOX68669.1;KOX73754.1;KOX72976.1;KOX80899.1;KOX67484.1 Reactome: R-HSA-202424 Downstream TCR signaling 43 KOX70383.1;KOX78786.1;KOX68313.1;KOX72982.1;KOX80285.1;KOX77271.1;KOX79363.1;KOX79230.1;KOX70419.1;KOX72105.1;KOX79601.1;KOX69414.1;KOX78362.1;KOX78273.1;KOX68748.1;KOX69333.1;KOX75968.1;KOX70760.1;KOX75998.1;KOX80008.1;KOX79626.1;KOX76416.1;KOX67229.1;KOX73060.1;KOX76009.1;KOX70009.1;KOX70598.1;KOX68314.1;KOX72411.1;KOX79430.1;KOX76879.1;KOX78266.1;KOX73209.1;KOX74011.1;KOX74924.1;KOX69688.1;KOX79433.1;KOX75984.1;KOX74910.1;KOX80582.1;KOX71606.1;KOX72468.1;KOX78268.1 Reactome: R-HSA-6791055 TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P 1 KOX67931.1 MetaCyc: PWY-6470 Peptidoglycan biosynthesis V (beta-lactam resistance) 1 KOX77790.1 Reactome: R-HSA-176187 Activation of ATR in response to replication stress 28 KOX79615.1;KOX76493.1;KOX71452.1;KOX69273.1;KOX70456.1;KOX79522.1;KOX72070.1;KOX69890.1;KOX74923.1;KOX73670.1;KOX68806.1;KOX79548.1;KOX73262.1;KOX70391.1;KOX70033.1;KOX75506.1;KOX72417.1;KOX77320.1;KOX79987.1;KOX73285.1;KOX76415.1;KOX80006.1;KOX70402.1;KOX71424.1;KOX67686.1;KOX80991.1;KOX74494.1;KOX73022.1 Reactome: R-HSA-163560 Triglyceride catabolism 5 KOX71725.1;KOX69703.1;KOX74139.1;KOX80857.1;KOX78959.1 Reactome: R-HSA-5654720 PI-3K cascade:FGFR4 1 KOX81204.1 MetaCyc: PWY-5108 L-isoleucine biosynthesis V 2 KOX74892.1;KOX72274.1 Reactome: R-HSA-8853659 RET signaling 5 KOX74139.1;KOX81204.1;KOX70804.1;KOX67779.1;KOX70812.1 Reactome: R-HSA-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 39 KOX80582.1;KOX71606.1;KOX78268.1;KOX72468.1;KOX73209.1;KOX74011.1;KOX74924.1;KOX79433.1;KOX74910.1;KOX75984.1;KOX70598.1;KOX72411.1;KOX68314.1;KOX78266.1;KOX76879.1;KOX79430.1;KOX73060.1;KOX67229.1;KOX76416.1;KOX70009.1;KOX76009.1;KOX75968.1;KOX70760.1;KOX80008.1;KOX79626.1;KOX69414.1;KOX78273.1;KOX69333.1;KOX68748.1;KOX79230.1;KOX72105.1;KOX70419.1;KOX79601.1;KOX70383.1;KOX68313.1;KOX78786.1;KOX72982.1;KOX79363.1;KOX77271.1 KEGG: 00790+2.10.1.1 Folate biosynthesis 1 KOX81080.1 Reactome: R-HSA-432722 Golgi Associated Vesicle Biogenesis 8 KOX81056.1;KOX69308.1;KOX76817.1;KOX73246.1;KOX76818.1;KOX69726.1;KOX78458.1;KOX74369.1 Reactome: R-HSA-4549349 Defective ALG2 causes ALG2-CDG (CDG-1i) 1 KOX71738.1 MetaCyc: PWY-7887 Protein SAMPylation and SAMP-mediated thiolation 2 KOX71043.1;KOX71682.1 MetaCyc: PWY-5481 Pyruvate fermentation to (S)-lactate 2 KOX77688.1;KOX77687.1 KEGG: 00230+2.7.1.25 Purine metabolism 2 KOX74601.1;KOX68057.1 KEGG: 00710+3.1.3.11 Carbon fixation in photosynthetic organisms 1 KOX68814.1 KEGG: 00051+2.7.1.1 Fructose and mannose metabolism 2 KOX80688.1;KOX72065.1 Reactome: R-HSA-1482883 Acyl chain remodeling of DAG and TAG 1 KOX72546.1 MetaCyc: PWY-6124 Inosine-5'-phosphate biosynthesis II 3 KOX67690.1;KOX71802.1;KOX71530.1 MetaCyc: PWY-1361 Benzoyl-coa degradation I (aerobic) 2 KOX76405.1;KOX75101.1 KEGG: 00030+1.1.1.44 Pentose phosphate pathway 1 KOX72985.1 Reactome: R-HSA-69231 Cyclin D associated events in G1 14 KOX71723.1;KOX80895.1;KOX72105.1;KOX76312.1;KOX79430.1;KOX72538.1;KOX81403.1;KOX70149.1;KOX67229.1;KOX70935.1;KOX80899.1;KOX70054.1;KOX69688.1;KOX79433.1 Reactome: R-HSA-5358751 S45 mutants of beta-catenin aren't phosphorylated 5 KOX73320.1;KOX76312.1;KOX71037.1;KOX75788.1;KOX69536.1 KEGG: 00471+3.5.1.2 D-Glutamine and D-glutamate metabolism 1 KOX80357.1 Reactome: R-HSA-9614657 FOXO-mediated transcription of cell death genes 4 KOX73868.1;KOX77410.1;KOX69665.1;KOX74479.1 Reactome: R-HSA-3359473 Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD 1 KOX76209.1 Reactome: R-HSA-73772 RNA Polymerase I Promoter Escape 24 KOX72380.1;KOX69897.1;KOX74217.1;KOX77062.1;KOX81403.1;KOX72538.1;KOX68859.1;KOX81200.1;KOX79649.1;KOX73785.1;KOX74214.1;KOX73198.1;KOX81203.1;KOX70030.1;KOX71263.1;KOX77063.1;KOX74919.1;KOX77330.1;KOX69719.1;KOX72899.1;KOX67437.1;KOX69540.1;KOX74030.1;KOX77626.1 KEGG: 00220+4.3.2.1 Arginine biosynthesis 1 KOX81392.1 MetaCyc: PWY-5966-1 Fatty acid biosynthesis initiation (animals and fungi, cytoplasm) 3 KOX70011.1;KOX69550.1;KOX73549.1 MetaCyc: PWY-6689 Trna splicing I 2 KOX77706.1;KOX80010.1 MetaCyc: PWY-6871 3-methylbutanol biosynthesis (engineered) 1 KOX67600.1 Reactome: R-HSA-189200 Cellular hexose transport 21 KOX72026.1;KOX72175.1;KOX77510.1;KOX67560.1;KOX71833.1;KOX74499.1;KOX80254.1;KOX72424.1;KOX76211.1;KOX79300.1;KOX67160.1;KOX79603.1;KOX68805.1;KOX79659.1;KOX70761.1;KOX80765.1;KOX70255.1;KOX79412.1;KOX70763.1;KOX71961.1;KOX79494.1 Reactome: R-HSA-4086398 Ca2+ pathway 17 KOX69081.1;KOX79467.1;KOX74484.1;KOX75330.1;KOX67626.1;KOX70201.1;KOX75998.1;KOX67889.1;KOX68332.1;KOX72584.1;KOX74580.1;KOX76508.1;KOX79656.1;KOX72581.1;KOX68440.1;KOX73812.1;KOX78343.1 Reactome: R-HSA-392451 G beta:gamma signalling through PI3Kgamma 7 KOX69081.1;KOX78362.1;KOX79656.1;KOX78343.1;KOX76508.1;KOX79467.1;KOX72400.1 KEGG: 00983+3.6.1.23 Drug metabolism - other enzymes 1 KOX80533.1 Reactome: R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange 25 KOX71763.1;KOX80991.1;KOX68054.1;KOX68858.1;KOX71786.1;KOX71424.1;KOX70402.1;KOX79196.1;KOX68243.1;KOX73285.1;KOX72417.1;KOX79987.1;KOX67721.1;KOX80977.1;KOX79548.1;KOX73599.1;KOX73670.1;KOX74923.1;KOX69173.1;KOX74812.1;KOX72024.1;KOX78861.1;KOX79522.1;KOX68669.1;KOX71452.1 Reactome: R-HSA-6782315 tRNA modification in the nucleus and cytosol 28 KOX79251.1;KOX72241.1;KOX80753.1;KOX73195.1;KOX69380.1;KOX76640.1;KOX68672.1;KOX73653.1;KOX77851.1;KOX71948.1;KOX72801.1;KOX73346.1;KOX76511.1;KOX76281.1;KOX81230.1;KOX80919.1;KOX76647.1;KOX67520.1;KOX75292.1;KOX79464.1;KOX77842.1;KOX77698.1;KOX67731.1;KOX67568.1;KOX69853.1;KOX73675.1;KOX77364.1;KOX68039.1 Reactome: R-HSA-199220 Vitamin B5 (pantothenate) metabolism 3 KOX69550.1;KOX75794.1;KOX73549.1 KEGG: 00071+2.3.1.21 Fatty acid degradation 1 KOX81081.1 MetaCyc: PWY-5 Canavanine biosynthesis 2 KOX81392.1;KOX69117.1 MetaCyc: PWY-7227 Adenosine deoxyribonucleotides de novo biosynthesis 5 KOX76865.1;KOX78158.1;KOX79885.1;KOX71458.1;KOX78412.1 Reactome: R-HSA-110329 Cleavage of the damaged pyrimidine 8 KOX70328.1;KOX75509.1;KOX74010.1;KOX74214.1;KOX77492.1;KOX74217.1;KOX77019.1;KOX77330.1 Reactome: R-HSA-399956 CRMPs in Sema3A signaling 1 KOX73729.1 KEGG: 00073+1.2.1.84 Cutin, suberine and wax biosynthesis 25 KOX72289.1;KOX68693.1;KOX68371.1;KOX74747.1;KOX80980.1;KOX76705.1;KOX77819.1;KOX76200.1;KOX67582.1;KOX67276.1;KOX72974.1;KOX76757.1;KOX70665.1;KOX70026.1;KOX67575.1;KOX67285.1;KOX68699.1;KOX67261.1;KOX68698.1;KOX67284.1;KOX67581.1;KOX74314.1;KOX67597.1;KOX70025.1;KOX75132.1 KEGG: 00230+2.7.6.1 Purine metabolism 2 KOX68809.1;KOX69375.1 KEGG: 00730+2.7.4.3 Thiamine metabolism 8 KOX79001.1;KOX80742.1;KOX77775.1;KOX73294.1;KOX71192.1;KOX76788.1;KOX78323.1;KOX78710.1 Reactome: R-HSA-73856 RNA Polymerase II Transcription Termination 36 KOX75678.1;KOX79897.1;KOX79860.1;KOX73851.1;KOX73274.1;KOX74624.1;KOX71605.1;KOX79387.1;KOX78065.1;KOX74745.1;KOX69435.1;KOX73449.1;KOX67153.1;KOX73083.1;KOX77767.1;KOX78050.1;KOX68896.1;KOX71437.1;KOX75816.1;KOX72920.1;KOX74908.1;KOX77867.1;KOX75336.1;KOX73321.1;KOX74909.1;KOX75893.1;KOX72752.1;KOX73304.1;KOX72220.1;KOX79349.1;KOX68477.1;KOX74386.1;KOX81159.1;KOX68575.1;KOX67341.1;KOX71803.1 MetaCyc: PWY-8043 Ophthalmate biosynthesis 2 KOX78147.1;KOX76540.1 MetaCyc: PWY-6554 1D-myo-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3) 3 KOX81095.1;KOX80873.1;KOX81098.1 MetaCyc: PWY-7102 Bisabolene biosynthesis (engineered) 2 KOX74855.1;KOX72808.1 Reactome: R-HSA-2682334 EPH-Ephrin signaling 2 KOX79159.1;KOX73839.1 Reactome: R-HSA-210500 Glutamate Neurotransmitter Release Cycle 3 KOX74367.1;KOX80357.1;KOX74364.1 KEGG: 00561+2.7.1.30 Glycerolipid metabolism 6 KOX80352.1;KOX74206.1;KOX68683.1;KOX70335.1;KOX80353.1;KOX71603.1 KEGG: 04714+2.7.11.1 Thermogenesis 40 KOX73724.1;KOX79522.1;KOX78362.1;KOX71595.1;KOX79166.1;KOX73362.1;KOX68084.1;KOX73800.1;KOX68654.1;KOX79033.1;KOX77506.1;KOX68521.1;KOX74479.1;KOX70561.1;KOX77803.1;KOX79039.1;KOX68566.1;KOX70676.1;KOX79935.1;KOX76221.1;KOX69995.1;KOX79225.1;KOX72400.1;KOX73463.1;KOX78841.1;KOX77364.1;KOX76214.1;KOX81246.1;KOX68647.1;KOX74477.1;KOX78509.1;KOX77898.1;KOX79675.1;KOX70861.1;KOX72201.1;KOX74186.1;KOX69619.1;KOX79817.1;KOX68054.1;KOX71579.1 Reactome: R-HSA-167238 Pausing and recovery of Tat-mediated HIV elongation 23 KOX71506.1;KOX75987.1;KOX79649.1;KOX77062.1;KOX74806.1;KOX80159.1;KOX77626.1;KOX78553.1;KOX70044.1;KOX74945.1;KOX77418.1;KOX81395.1;KOX72082.1;KOX67200.1;KOX77063.1;KOX68573.1;KOX70730.1;KOX69424.1;KOX81203.1;KOX78696.1;KOX67799.1;KOX73198.1;KOX67622.1 Reactome: R-HSA-912631 Regulation of signaling by CBL 7 KOX79433.1;KOX79430.1;KOX72105.1;KOX81245.1;KOX81204.1;KOX70804.1;KOX67229.1 Reactome: R-HSA-5674135 MAP2K and MAPK activation 5 KOX72912.1;KOX68521.1;KOX79918.1;KOX68500.1;KOX80754.1 Reactome: R-HSA-210993 Tie2 Signaling 1 KOX81204.1 Reactome: R-HSA-140837 Intrinsic Pathway of Fibrin Clot Formation 1 KOX70403.1 KEGG: 00770+2.6.1.42 Pantothenate and CoA biosynthesis 1 KOX72274.1 MetaCyc: PWY-7411 Phosphatidate biosynthesis (yeast) 8 KOX80280.1;KOX76514.1;KOX77858.1;KOX79114.1;KOX75465.1;KOX67923.1;KOX75460.1;KOX75990.1 Reactome: R-HSA-111367 SLBP independent Processing of Histone Pre-mRNAs 6 KOX74909.1;KOX73321.1;KOX74908.1;KOX78050.1;KOX79387.1;KOX78065.1 KEGG: 00620+6.4.1.1 Pyruvate metabolism 1 KOX68340.1 MetaCyc: PWY-7761 NAD salvage pathway II (PNC IV cycle) 2 KOX80677.1;KOX78680.1 KEGG: 00500+3.2.1.1 Starch and sucrose metabolism 1 KOX70625.1 Reactome: R-HSA-948021 Transport to the Golgi and subsequent modification 1 KOX74767.1 MetaCyc: PWY-7204 Pyridoxal 5'-phosphate salvage II (plants) 3 KOX80439.1;KOX70645.1;KOX67899.1 Reactome: R-HSA-111458 Formation of apoptosome 5 KOX73754.1;KOX69899.1;KOX69910.1;KOX74588.1;KOX78094.1 KEGG: 00230+1.17.1.4 Purine metabolism 1 KOX71781.1 Reactome: R-HSA-6811438 Intra-Golgi traffic 19 KOX77702.1;KOX68899.1;KOX71647.1;KOX73107.1;KOX71890.1;KOX80114.1;KOX76079.1;KOX74768.1;KOX74480.1;KOX72450.1;KOX72178.1;KOX77238.1;KOX77544.1;KOX74024.1;KOX77841.1;KOX78763.1;KOX77542.1;KOX79043.1;KOX69822.1 Reactome: R-HSA-165054 Rev-mediated nuclear export of HIV RNA 22 KOX73664.1;KOX77505.1;KOX73131.1;KOX77058.1;KOX75540.1;KOX79264.1;KOX79242.1;KOX68874.1;KOX81376.1;KOX75811.1;KOX72429.1;KOX75539.1;KOX75630.1;KOX80793.1;KOX79436.1;KOX68732.1;KOX69417.1;KOX73226.1;KOX80341.1;KOX78183.1;KOX72473.1;KOX69061.1 Reactome: R-HSA-171306 Packaging Of Telomere Ends 3 KOX74217.1;KOX77330.1;KOX74214.1 KEGG: 00230+3.6.1.9 Purine metabolism 2 KOX69334.1;KOX80826.1 MetaCyc: PWY-7285 Methylwyosine biosynthesis 2 KOX67520.1;KOX72874.1 KEGG: 00561+2.3.1.20 Glycerolipid metabolism 3 KOX72546.1;KOX77336.1;KOX78377.1 Reactome: R-HSA-201681 TCF dependent signaling in response to WNT 10 KOX70197.1;KOX68742.1;KOX79430.1;KOX72651.1;KOX72105.1;KOX67229.1;KOX70322.1;KOX71684.1;KOX80121.1;KOX79433.1 MetaCyc: PWY-6902 Chitin degradation II (Vibrio) 10 KOX75966.1;KOX74395.1;KOX79324.1;KOX73530.1;KOX74631.1;KOX77106.1;KOX74285.1;KOX79466.1;KOX72270.1;KOX79627.1 MetaCyc: PWY-7980 ATP biosynthesis 4 KOX73541.1;KOX78342.1;KOX72760.1;KOX79538.1 Reactome: R-HSA-2214320 Anchoring fibril formation 3 KOX75720.1;KOX75270.1;KOX75715.1 KEGG: 00240+2.7.4.9 Pyrimidine metabolism 1 KOX79122.1 Reactome: R-HSA-192823 Viral mRNA Translation 78 KOX73889.1;KOX68929.1;KOX73120.1;KOX78826.1;KOX67227.1;KOX78670.1;KOX75358.1;KOX70874.1;KOX68107.1;KOX68744.1;KOX74804.1;KOX78289.1;KOX73450.1;KOX68042.1;KOX67699.1;KOX71403.1;KOX67229.1;KOX75143.1;KOX77188.1;KOX70176.1;KOX72330.1;KOX79611.1;KOX79430.1;KOX67935.1;KOX81212.1;KOX70147.1;KOX67698.1;KOX72074.1;KOX73308.1;KOX75958.1;KOX67807.1;KOX71394.1;KOX71471.1;KOX70724.1;KOX78800.1;KOX67795.1;KOX74407.1;KOX81388.1;KOX74170.1;KOX79914.1;KOX69807.1;KOX74668.1;KOX72644.1;KOX67280.1;KOX77134.1;KOX72105.1;KOX73982.1;KOX81215.1;KOX72660.1;KOX78350.1;KOX71077.1;KOX75483.1;KOX72185.1;KOX76065.1;KOX75024.1;KOX74357.1;KOX75797.1;KOX77911.1;KOX74637.1;KOX68431.1;KOX71988.1;KOX73344.1;KOX79160.1;KOX67361.1;KOX71651.1;KOX75227.1;KOX80864.1;KOX77016.1;KOX70024.1;KOX79433.1;KOX79738.1;KOX78568.1;KOX76900.1;KOX75432.1;KOX75945.1;KOX72125.1;KOX72904.1;KOX67237.1 Reactome: R-HSA-170670 Adenylate cyclase inhibitory pathway 3 KOX73149.1;KOX69402.1;KOX78138.1 Reactome: R-HSA-174411 Polymerase switching on the C-strand of the telomere 16 KOX77326.1;KOX67310.1;KOX81161.1;KOX70673.1;KOX73285.1;KOX78863.1;KOX74923.1;KOX78024.1;KOX79548.1;KOX69330.1;KOX71969.1;KOX71452.1;KOX78132.1;KOX79678.1;KOX77356.1;KOX81364.1 KEGG: 05165+2.7.1.153 Human papillomavirus infection 1 KOX79243.1 MetaCyc: PWY-5480 Pyruvate fermentation to ethanol I 1 KOX67600.1 MetaCyc: PWY-5891 Menaquinol-11 biosynthesis 1 KOX75964.1 KEGG: 00270+5.3.1.23 Cysteine and methionine metabolism 4 KOX72189.1;KOX70443.1;KOX72835.1;KOX73121.1 Reactome: R-HSA-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 10 KOX73267.1;KOX71992.1;KOX72154.1;KOX79389.1;KOX74165.1;KOX71898.1;KOX76684.1;KOX76210.1;KOX74256.1;KOX72749.1 Reactome: R-HSA-1660516 Synthesis of PIPs at the early endosome membrane 4 KOX70260.1;KOX79807.1;KOX76722.1;KOX78498.1 Reactome: R-HSA-389359 CD28 dependent Vav1 pathway 3 KOX81204.1;KOX78779.1;KOX76191.1 Reactome: R-HSA-197264 Nicotinamide salvaging 3 KOX68906.1;KOX78224.1;KOX68350.1 KEGG: 00900+2.5.1.10+2.5.1.1 Terpenoid backbone biosynthesis 1 KOX72808.1 Reactome: R-HSA-9665246 Resistance of ERBB2 KD mutants to neratinib 1 KOX73791.1 KEGG: 00760+2.7.1.23 Nicotinate and nicotinamide metabolism 1 KOX79573.1 KEGG: 00250+2.6.1.19 Alanine, aspartate and glutamate metabolism 1 KOX75380.1 MetaCyc: PWY-6365 D-myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis 1 KOX80873.1 KEGG: 00620+1.1.1.37 Pyruvate metabolism 5 KOX75374.1;KOX68928.1;KOX70049.1;KOX69541.1;KOX70050.1 Reactome: R-HSA-6807878 COPI-mediated anterograde transport 50 KOX75609.1;KOX80782.1;KOX72161.1;KOX72163.1;KOX77793.1;KOX71404.1;KOX72164.1;KOX68241.1;KOX78693.1;KOX73107.1;KOX71890.1;KOX76079.1;KOX69879.1;KOX72162.1;KOX70129.1;KOX75989.1;KOX79174.1;KOX69987.1;KOX75272.1;KOX72302.1;KOX79744.1;KOX72450.1;KOX79067.1;KOX73740.1;KOX78763.1;KOX75785.1;KOX71096.1;KOX67706.1;KOX73974.1;KOX72843.1;KOX75429.1;KOX68198.1;KOX69822.1;KOX77419.1;KOX69877.1;KOX79043.1;KOX74949.1;KOX72021.1;KOX73744.1;KOX75211.1;KOX68899.1;KOX77702.1;KOX72469.1;KOX72895.1;KOX80114.1;KOX75646.1;KOX67801.1;KOX74480.1;KOX75027.1;KOX77238.1 KEGG: 00983+2.7.1.48 Drug metabolism - other enzymes 2 KOX78077.1;KOX79373.1 KEGG: 00040+1.1.1.22 Pentose and glucuronate interconversions 1 KOX69806.1 MetaCyc: PWY-7291 Oleate beta-oxidation (isomerase-dependent, yeast) 2 KOX71616.1;KOX73119.1 KEGG: 00240+2.4.2.1 Pyrimidine metabolism 1 KOX78203.1 Reactome: R-HSA-167162 RNA Polymerase II HIV Promoter Escape 29 KOX77063.1;KOX74919.1;KOX69719.1;KOX81398.1;KOX73198.1;KOX81203.1;KOX70044.1;KOX69540.1;KOX74030.1;KOX77626.1;KOX68729.1;KOX77334.1;KOX67200.1;KOX71842.1;KOX77418.1;KOX71518.1;KOX69897.1;KOX68559.1;KOX77062.1;KOX81403.1;KOX74930.1;KOX74806.1;KOX69085.1;KOX73785.1;KOX77907.1;KOX72538.1;KOX78263.1;KOX71363.1;KOX79649.1 MetaCyc: PWY-7592 Arachidonate biosynthesis III (6-desaturase, mammals) 2 KOX78236.1;KOX79701.1 Reactome: R-HSA-174430 Telomere C-strand synthesis initiation 7 KOX69330.1;KOX78863.1;KOX79678.1;KOX77830.1;KOX78132.1;KOX77276.1;KOX81161.1 KEGG: 00071+1.3.3.6 Fatty acid degradation 2 KOX71616.1;KOX73119.1 KEGG: 00480+1.1.1.44 Glutathione metabolism 1 KOX72985.1 Reactome: R-HSA-5656121 Translesion synthesis by POLI 16 KOX72105.1;KOX79430.1;KOX70402.1;KOX67310.1;KOX73285.1;KOX80464.1;KOX72417.1;KOX70673.1;KOX67229.1;KOX79548.1;KOX74923.1;KOX78024.1;KOX79433.1;KOX71969.1;KOX71452.1;KOX76509.1 Reactome: R-HSA-983712 Ion channel transport 13 KOX75953.1;KOX74155.1;KOX71792.1;KOX78327.1;KOX73541.1;KOX79728.1;KOX76903.1;KOX70575.1;KOX69852.1;KOX77098.1;KOX72144.1;KOX75459.1;KOX72760.1 Reactome: R-HSA-5419276 Mitochondrial translation termination 59 KOX70965.1;KOX79930.1;KOX72466.1;KOX74822.1;KOX78569.1;KOX68660.1;KOX77007.1;KOX68333.1;KOX75877.1;KOX80515.1;KOX74566.1;KOX77508.1;KOX75293.1;KOX75790.1;KOX79904.1;KOX78474.1;KOX74981.1;KOX68803.1;KOX71986.1;KOX73642.1;KOX75346.1;KOX71667.1;KOX73981.1;KOX71622.1;KOX79803.1;KOX74807.1;KOX80218.1;KOX67717.1;KOX77105.1;KOX81198.1;KOX79170.1;KOX79468.1;KOX69763.1;KOX75094.1;KOX67170.1;KOX75286.1;KOX77237.1;KOX71678.1;KOX67841.1;KOX77532.1;KOX71749.1;KOX71465.1;KOX74292.1;KOX73806.1;KOX70128.1;KOX78312.1;KOX77437.1;KOX77966.1;KOX72631.1;KOX72346.1;KOX81353.1;KOX77822.1;KOX79602.1;KOX79944.1;KOX70731.1;KOX78643.1;KOX77079.1;KOX70114.1;KOX68193.1 Reactome: R-HSA-500657 Presynaptic function of Kainate receptors 6 KOX79467.1;KOX75330.1;KOX76508.1;KOX79656.1;KOX78343.1;KOX69081.1 KEGG: 00790+4.2.1.96 Folate biosynthesis 1 KOX75737.1 Reactome: R-HSA-181429 Serotonin Neurotransmitter Release Cycle 2 KOX74364.1;KOX74367.1 Reactome: R-HSA-72702 Ribosomal scanning and start codon recognition 54 KOX75797.1;KOX70174.1;KOX68107.1;KOX75024.1;KOX76065.1;KOX75483.1;KOX70874.1;KOX71077.1;KOX74637.1;KOX77911.1;KOX71988.1;KOX75064.1;KOX68431.1;KOX79833.1;KOX70202.1;KOX68213.1;KOX77634.1;KOX79914.1;KOX73889.1;KOX78826.1;KOX72644.1;KOX67969.1;KOX70175.1;KOX74668.1;KOX72470.1;KOX75967.1;KOX77134.1;KOX70024.1;KOX67810.1;KOX67807.1;KOX75958.1;KOX76900.1;KOX72074.1;KOX79433.1;KOX72125.1;KOX71394.1;KOX69593.1;KOX80758.1;KOX67237.1;KOX70051.1;KOX78800.1;KOX72904.1;KOX67795.1;KOX67229.1;KOX69831.1;KOX70570.1;KOX70176.1;KOX75227.1;KOX80902.1;KOX77016.1;KOX69171.1;KOX80864.1;KOX81212.1;KOX79430.1 KEGG: 00030+3.1.1.31 Pentose phosphate pathway 1 KOX81368.1 Reactome: R-HSA-5423646 Aflatoxin activation and detoxification 8 KOX76314.1;KOX70888.1;KOX71899.1;KOX71712.1;KOX81309.1;KOX74679.1;KOX69073.1;KOX70890.1 MetaCyc: PWY-7936 Psilocybin biosynthesis 16 KOX76655.1;KOX69156.1;KOX74964.1;KOX80998.1;KOX69278.1;KOX79783.1;KOX75449.1;KOX79801.1;KOX76656.1;KOX79775.1;KOX69155.1;KOX79802.1;KOX69158.1;KOX77392.1;KOX69154.1;KOX67943.1 MetaCyc: PWY-7849 Urate conversion to allantoin III 1 KOX78431.1 Reactome: R-HSA-5621575 CD209 (DC-SIGN) signaling 2 KOX74139.1;KOX69665.1 Reactome: R-HSA-2122948 Activated NOTCH1 Transmits Signal to the Nucleus 14 KOX79433.1;KOX68228.1;KOX69998.1;KOX70021.1;KOX67229.1;KOX72334.1;KOX77003.1;KOX72031.1;KOX79430.1;KOX72105.1;KOX79871.1;KOX72702.1;KOX67619.1;KOX77051.1 Reactome: R-HSA-5619039 Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN) 1 KOX75298.1 Reactome: R-HSA-1253288 Downregulation of ERBB4 signaling 4 KOX79430.1;KOX79433.1;KOX72105.1;KOX67229.1 Reactome: R-HSA-8948751 Regulation of PTEN stability and activity 44 KOX80582.1;KOX78268.1;KOX72468.1;KOX71606.1;KOX72400.1;KOX74011.1;KOX73209.1;KOX79369.1;KOX77551.1;KOX80121.1;KOX74910.1;KOX75984.1;KOX74924.1;KOX79433.1;KOX72411.1;KOX68314.1;KOX70598.1;KOX76879.1;KOX78266.1;KOX79430.1;KOX73060.1;KOX67229.1;KOX76416.1;KOX70009.1;KOX76009.1;KOX70760.1;KOX70197.1;KOX75968.1;KOX79626.1;KOX80008.1;KOX78273.1;KOX69414.1;KOX69333.1;KOX68748.1;KOX79230.1;KOX79601.1;KOX72105.1;KOX70419.1;KOX68313.1;KOX78786.1;KOX70383.1;KOX77271.1;KOX79363.1;KOX72982.1 Reactome: R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint 53 KOX70598.1;KOX68314.1;KOX68198.1;KOX72411.1;KOX72843.1;KOX76879.1;KOX78266.1;KOX79430.1;KOX73060.1;KOX67229.1;KOX76416.1;KOX70009.1;KOX76009.1;KOX80582.1;KOX71606.1;KOX78268.1;KOX72468.1;KOX73209.1;KOX74011.1;KOX72895.1;KOX74924.1;KOX79433.1;KOX74910.1;KOX75984.1;KOX77793.1;KOX72164.1;KOX79230.1;KOX72105.1;KOX72163.1;KOX70419.1;KOX72161.1;KOX79601.1;KOX70383.1;KOX68313.1;KOX78786.1;KOX72982.1;KOX79363.1;KOX77271.1;KOX75968.1;KOX79744.1;KOX72302.1;KOX70760.1;KOX80008.1;KOX75272.1;KOX79174.1;KOX79626.1;KOX70129.1;KOX72162.1;KOX69879.1;KOX69414.1;KOX78273.1;KOX69333.1;KOX68748.1 Reactome: R-HSA-3065678 SUMO is transferred from E1 to E2 (UBE2I, UBC9) 1 KOX78175.1 MetaCyc: PWY-6607 Guanosine nucleotides degradation I 3 KOX71781.1;KOX75972.1;KOX75971.1 KEGG: 00190+3.6.1.1 Oxidative phosphorylation 2 KOX68266.1;KOX78499.1 KEGG: 04070+2.7.1.137 Phosphatidylinositol signaling system 1 KOX76722.1 Reactome: R-HSA-6781823 Formation of TC-NER Pre-Incision Complex 35 KOX72890.1;KOX72105.1;KOX77626.1;KOX67875.1;KOX70044.1;KOX69540.1;KOX70663.1;KOX70388.1;KOX73551.1;KOX73198.1;KOX77063.1;KOX72538.1;KOX71193.1;KOX73512.1;KOX81403.1;KOX69259.1;KOX72917.1;KOX69897.1;KOX79430.1;KOX67200.1;KOX68485.1;KOX74030.1;KOX77023.1;KOX77020.1;KOX81203.1;KOX78035.1;KOX71018.1;KOX74919.1;KOX69719.1;KOX67229.1;KOX79649.1;KOX73785.1;KOX69032.1;KOX79433.1;KOX77062.1 Reactome: R-HSA-180024 DARPP-32 events 8 KOX74139.1;KOX68255.1;KOX73490.1;KOX73489.1;KOX71184.1;KOX76312.1;KOX68259.1;KOX68258.1 KEGG: 00564+3.1.1.4 Glycerophospholipid metabolism 7 KOX77917.1;KOX70330.1;KOX72448.1;KOX79218.1;KOX69576.1;KOX75783.1;KOX69497.1 MetaCyc: PWY-8001 Felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis 3 KOX79924.1;KOX78785.1;KOX71346.1 KEGG: 00450+2.7.7.4 Selenocompound metabolism 2 KOX68057.1;KOX74601.1 Reactome: R-HSA-4793952 Defective MGAT2 causes MGAT2-CDG (CDG-2a) 1 KOX79732.1 Reactome: R-HSA-5651801 PCNA-Dependent Long Patch Base Excision Repair 17 KOX72417.1;KOX70673.1;KOX73285.1;KOX70402.1;KOX77276.1;KOX77326.1;KOX67310.1;KOX71452.1;KOX71969.1;KOX77974.1;KOX77356.1;KOX70179.1;KOX81364.1;KOX74923.1;KOX78024.1;KOX77830.1;KOX79548.1 KEGG: 00460+2.3.2.2 Cyanoamino acid metabolism 3 KOX78785.1;KOX71346.1;KOX79924.1 MetaCyc: PWY-7007 Methyl ketone biosynthesis (engineered) 4 KOX76405.1;KOX71616.1;KOX73119.1;KOX75101.1 Reactome: R-HSA-5620924 Intraflagellar transport 19 KOX75331.1;KOX77272.1;KOX77558.1;KOX72021.1;KOX68201.1;KOX75502.1;KOX79997.1;KOX80369.1;KOX81275.1;KOX73094.1;KOX72020.1;KOX76002.1;KOX75339.1;KOX78032.1;KOX76340.1;KOX68886.1;KOX69667.1;KOX68047.1;KOX71475.1 Reactome: R-HSA-5617833 Cilium Assembly 15 KOX69879.1;KOX72162.1;KOX70129.1;KOX72895.1;KOX71873.1;KOX79744.1;KOX72843.1;KOX72302.1;KOX77793.1;KOX68198.1;KOX72164.1;KOX72163.1;KOX75272.1;KOX72161.1;KOX79174.1 KEGG: 00410+4.2.1.17 beta-Alanine metabolism 2 KOX76405.1;KOX75101.1 KEGG: 04070+2.7.1.153 Phosphatidylinositol signaling system 1 KOX79243.1 Reactome: R-HSA-5083627 Defective LARGE causes MDDGA6 and MDDGB6 1 KOX69179.1 Reactome: R-HSA-9656255 Defective OGG1 Substrate Binding 1 KOX70328.1 Reactome: R-HSA-879415 Advanced glycosylation endproduct receptor signaling 5 KOX75568.1;KOX69658.1;KOX67259.1;KOX78325.1;KOX68500.1 Reactome: R-HSA-203641 NOSTRIN mediated eNOS trafficking 1 KOX67176.1 KEGG: 00260+1.1.1.1 Glycine, serine and threonine metabolism 1 KOX67600.1 Reactome: R-HSA-2995383 Initiation of Nuclear Envelope Reformation 3 KOX76312.1;KOX81389.1;KOX76830.1 MetaCyc: PWY-6352 3-phosphoinositide biosynthesis 4 KOX76722.1;KOX79243.1;KOX76348.1;KOX79807.1 Reactome: R-HSA-202433 Generation of second messenger molecules 2 KOX71582.1;KOX79176.1 Reactome: R-HSA-389977 Post-chaperonin tubulin folding pathway 10 KOX68198.1;KOX77793.1;KOX72302.1;KOX72843.1;KOX79744.1;KOX68775.1;KOX75272.1;KOX69879.1;KOX69855.1;KOX76266.1 Reactome: R-HSA-381038 XBP1(S) activates chaperone genes 8 KOX70394.1;KOX68044.1;KOX72007.1;KOX69877.1;KOX70543.1;KOX68929.1;KOX70646.1;KOX69868.1 MetaCyc: PWY-7433 Mucin core 1 and core 2 O-glycosylation 1 KOX71619.1 KEGG: 00630+1.1.1.37 Glyoxylate and dicarboxylate metabolism 5 KOX70050.1;KOX68928.1;KOX69541.1;KOX70049.1;KOX75374.1 KEGG: 00480+2.5.1.16 Glutathione metabolism 2 KOX74762.1;KOX80905.1 Reactome: R-HSA-141430 Inactivation of APC/C via direct inhibition of the APC/C complex 9 KOX76684.1;KOX76210.1;KOX74256.1;KOX72749.1;KOX73267.1;KOX71992.1;KOX72154.1;KOX79389.1;KOX71898.1 KEGG: 00360+4.2.1.17 Phenylalanine metabolism 2 KOX76405.1;KOX75101.1 Reactome: R-HSA-176034 Interactions of Tat with host cellular proteins 1 KOX67799.1 Reactome: R-HSA-6803211 TP53 Regulates Transcription of Death Receptors and Ligands 1 KOX80158.1 Reactome: R-HSA-525793 Myogenesis 6 KOX76191.1;KOX76204.1;KOX79525.1;KOX78779.1;KOX70294.1;KOX80895.1 Reactome: R-HSA-727802 Transport of nucleotide sugars 1 KOX79925.1 MetaCyc: PWY-7375 Mrna capping I 2 KOX79850.1;KOX76411.1 KEGG: 00513+3.2.1.52 Various types of N-glycan biosynthesis 4 KOX74395.1;KOX74285.1;KOX74631.1;KOX73530.1 Reactome: R-HSA-4655427 SUMOylation of DNA methylation proteins 3 KOX77963.1;KOX74441.1;KOX74005.1 MetaCyc: PWY-7115 C4 photosynthetic carbon assimilation cycle, NAD-ME type 10 KOX68087.1;KOX68932.1;KOX71428.1;KOX70049.1;KOX69541.1;KOX75374.1;KOX70050.1;KOX79912.1;KOX68928.1;KOX80775.1 KEGG: 00630+4.2.1.3 Glyoxylate and dicarboxylate metabolism 2 KOX73090.1;KOX71536.1 Reactome: R-HSA-1489509 DAG and IP3 signaling 1 KOX73812.1 Reactome: R-HSA-5657655 MGMT-mediated DNA damage reversal 1 KOX75802.1 Reactome: R-HSA-9617629 Regulation of FOXO transcriptional activity by acetylation 1 KOX69665.1 KEGG: 05170+2.7.1.153 Human immunodeficiency virus 1 infection 1 KOX79243.1 Reactome: R-HSA-1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 6 KOX73791.1;KOX72105.1;KOX79433.1;KOX79430.1;KOX67229.1;KOX81204.1 Reactome: R-HSA-5673001 RAF/MAP kinase cascade 11 KOX73103.1;KOX81204.1;KOX78706.1;KOX67779.1;KOX70812.1;KOX68226.1;KOX69097.1;KOX72629.1;KOX68537.1;KOX68500.1;KOX67928.1 MetaCyc: PWY-5129 Sphingolipid biosynthesis (plants) 2 KOX76503.1;KOX74918.1 KEGG: 00350+2.6.1.1 Tyrosine metabolism 2 KOX71428.1;KOX79912.1 KEGG: 00790+4.6.1.17 Folate biosynthesis 1 KOX69728.1 KEGG: 00513+2.4.1.257+2.4.1.132 Various types of N-glycan biosynthesis 1 KOX71738.1 Reactome: R-HSA-164378 PKA activation in glucagon signalling 5 KOX73149.1;KOX78138.1;KOX69402.1;KOX71184.1;KOX74139.1 MetaCyc: PWY-4381 Fatty acid biosynthesis initiation (bacteria and plants) 4 KOX73549.1;KOX69550.1;KOX70011.1;KOX79144.1 Reactome: R-HSA-8964539 Glutamate and glutamine metabolism 6 KOX79797.1;KOX75490.1;KOX80357.1;KOX79798.1;KOX70089.1;KOX79199.1 KEGG: 00280+1.2.4.4 Valine, leucine and isoleucine degradation 1 KOX75285.1 Reactome: R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 7 KOX76822.1;KOX75402.1;KOX71508.1;KOX67191.1;KOX77546.1;KOX76808.1;KOX72780.1 KEGG: 00534+5.1.3.17 Glycosaminoglycan biosynthesis - heparan sulfate / heparin 1 KOX68966.1 Reactome: R-HSA-5655862 Translesion synthesis by POLK 16 KOX72105.1;KOX79430.1;KOX70402.1;KOX67310.1;KOX73285.1;KOX80464.1;KOX72417.1;KOX70673.1;KOX67229.1;KOX79548.1;KOX74923.1;KOX78024.1;KOX79433.1;KOX71969.1;KOX71452.1;KOX76509.1 Reactome: R-HSA-6803157 Antimicrobial peptides 5 KOX72475.1;KOX72474.1;KOX68757.1;KOX70643.1;KOX71517.1 Reactome: R-HSA-1362409 Mitochondrial iron-sulfur cluster biogenesis 7 KOX77746.1;KOX79828.1;KOX69261.1;KOX79832.1;KOX74033.1;KOX68534.1;KOX74978.1 Reactome: R-HSA-392170 ADP signalling through P2Y purinoceptor 12 5 KOX79656.1;KOX78343.1;KOX69081.1;KOX76508.1;KOX79467.1 MetaCyc: PWY-5884 Wax esters biosynthesis I 25 KOX70025.1;KOX67597.1;KOX75132.1;KOX74314.1;KOX67581.1;KOX67284.1;KOX67261.1;KOX68698.1;KOX68699.1;KOX67285.1;KOX67575.1;KOX70026.1;KOX72974.1;KOX67276.1;KOX76757.1;KOX70665.1;KOX67582.1;KOX76200.1;KOX77819.1;KOX80980.1;KOX76705.1;KOX68371.1;KOX74747.1;KOX68693.1;KOX72289.1 Reactome: R-HSA-975577 N-Glycan antennae elongation 3 KOX70844.1;KOX80037.1;KOX76870.1 Reactome: R-HSA-74259 Purine catabolism 6 KOX69334.1;KOX79554.1;KOX73844.1;KOX78203.1;KOX79553.1;KOX71781.1 Reactome: R-HSA-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter 25 KOX73198.1;KOX81203.1;KOX77063.1;KOX74448.1;KOX72899.1;KOX72891.1;KOX70382.1;KOX77626.1;KOX67688.1;KOX67791.1;KOX74451.1;KOX81254.1;KOX76947.1;KOX68921.1;KOX71970.1;KOX68645.1;KOX77062.1;KOX77413.1;KOX67394.1;KOX77100.1;KOX80740.1;KOX81200.1;KOX79649.1;KOX75217.1;KOX77884.1 Reactome: R-HSA-164939 Nef mediated downregulation of CD28 cell surface expression 1 KOX69299.1 MetaCyc: PWY-7206 Pyrimidine deoxyribonucleotides dephosphorylation 2 KOX69334.1;KOX80826.1 KEGG: 00230+6.3.4.4 Purine metabolism 1 KOX81300.1 KEGG: 00510+2.7.1.108 N-Glycan biosynthesis 1 KOX67918.1 MetaCyc: PWY-5855 Ubiquinol-7 biosynthesis (prokaryotic) 3 KOX70323.1;KOX72023.1;KOX77776.1 MetaCyc: PWY-7766 Heme b biosynthesis IV (Gram-positive bacteria) 1 KOX75988.1 Reactome: R-HSA-674695 RNA Polymerase II Pre-transcription Events 53 KOX68573.1;KOX70730.1;KOX70864.1;KOX77063.1;KOX67622.1;KOX73198.1;KOX78696.1;KOX69540.1;KOX70044.1;KOX77626.1;KOX68729.1;KOX71842.1;KOX81395.1;KOX74945.1;KOX69897.1;KOX73186.1;KOX68559.1;KOX81403.1;KOX69309.1;KOX80159.1;KOX74806.1;KOX69085.1;KOX75987.1;KOX72538.1;KOX78263.1;KOX71363.1;KOX69424.1;KOX69719.1;KOX73587.1;KOX74919.1;KOX81398.1;KOX72967.1;KOX67799.1;KOX79279.1;KOX81203.1;KOX74030.1;KOX78553.1;KOX77334.1;KOX72082.1;KOX75631.1;KOX67200.1;KOX71518.1;KOX77418.1;KOX80906.1;KOX74916.1;KOX74908.1;KOX77062.1;KOX74930.1;KOX74909.1;KOX71506.1;KOX73785.1;KOX77907.1;KOX79649.1 MetaCyc: PWY-7625 Phosphatidylinositol biosynthesis II (eukaryotes) 1 KOX76348.1 Reactome: R-HSA-192456 Digestion of dietary lipid 1 KOX67326.1 Reactome: R-HSA-162588 Budding and maturation of HIV virion 10 KOX79430.1;KOX72105.1;KOX80074.1;KOX71636.1;KOX78305.1;KOX69076.1;KOX79433.1;KOX67229.1;KOX67716.1;KOX72168.1 Reactome: R-HSA-5661270 Formation of xylulose-5-phosphate 1 KOX73255.1 KEGG: 00620+1.8.1.4 Pyruvate metabolism 1 KOX75086.1 Reactome: R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis 21 KOX74217.1;KOX77062.1;KOX73517.1;KOX79649.1;KOX73880.1;KOX74214.1;KOX73198.1;KOX69665.1;KOX72851.1;KOX81203.1;KOX67191.1;KOX77063.1;KOX77330.1;KOX75454.1;KOX74546.1;KOX67200.1;KOX68069.1;KOX76309.1;KOX70044.1;KOX77626.1;KOX73641.1 Reactome: R-HSA-8939242 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes 1 KOX79878.1 MetaCyc: PWY-5491 Diethylphosphate degradation 4 KOX73008.1;KOX73014.1;KOX79580.1;KOX74128.1 Reactome: R-HSA-71240 Tryptophan catabolism 3 KOX80071.1;KOX70876.1;KOX71035.1 KEGG: 00562+5.5.1.4 Inositol phosphate metabolism 1 KOX68055.1 MetaCyc: PWY-7179 Purine deoxyribonucleosides degradation I 2 KOX78203.1;KOX71685.1 KEGG: 00514+2.4.1.221 Other types of O-glycan biosynthesis 1 KOX71405.1 KEGG: 00500+2.7.7.9 Starch and sucrose metabolism 1 KOX67374.1 Reactome: R-HSA-167287 HIV elongation arrest and recovery 23 KOX80159.1;KOX74806.1;KOX77062.1;KOX79649.1;KOX75987.1;KOX71506.1;KOX78696.1;KOX67799.1;KOX81203.1;KOX67622.1;KOX73198.1;KOX68573.1;KOX70730.1;KOX77063.1;KOX69424.1;KOX77418.1;KOX74945.1;KOX67200.1;KOX72082.1;KOX81395.1;KOX70044.1;KOX77626.1;KOX78553.1 MetaCyc: PWY-1042 Glycolysis IV (plant cytosol) 10 KOX67171.1;KOX71859.1;KOX74975.1;KOX76361.1;KOX72508.1;KOX76362.1;KOX81104.1;KOX74974.1;KOX67203.1;KOX67867.1 KEGG: 00760+2.7.7.18 Nicotinate and nicotinamide metabolism 1 KOX80677.1 Reactome: R-HSA-1971475 A tetrasaccharide linker sequence is required for GAG synthesis 7 KOX76492.1;KOX80364.1;KOX73118.1;KOX74901.1;KOX79480.1;KOX78102.1;KOX80363.1 Reactome: R-HSA-68616 Assembly of the ORC complex at the origin of replication 5 KOX67686.1;KOX69890.1;KOX73262.1;KOX79615.1;KOX70456.1 Reactome: R-HSA-8934593 Regulation of RUNX1 Expression and Activity 7 KOX67889.1;KOX68332.1;KOX70201.1;KOX74484.1;KOX74580.1;KOX79878.1;KOX70149.1 MetaCyc: PWY-5751 Phenylethanol biosynthesis 1 KOX67600.1 Reactome: R-HSA-3249367 STAT6-mediated induction of chemokines 1 KOX67371.1 MetaCyc: PWY-5659 GDP-mannose biosynthesis 3 KOX67919.1;KOX72772.1;KOX74805.1 MetaCyc: PWY-6122 5-aminoimidazole ribonucleotide biosynthesis II 3 KOX79954.1;KOX67689.1;KOX70064.1 KEGG: 00510+2.4.1.265 N-Glycan biosynthesis 1 KOX72002.1 KEGG: 00261+2.7.7.4 Monobactam biosynthesis 2 KOX68057.1;KOX74601.1 MetaCyc: PWY-5074 Mevalonate degradation 1 KOX72741.1 KEGG: 00380+2.6.1.7 Tryptophan metabolism 1 KOX80071.1 KEGG: 00982+1.1.1.1 Drug metabolism - cytochrome P450 1 KOX67600.1 Reactome: R-HSA-499943 Interconversion of nucleotide di- and triphosphates 16 KOX80742.1;KOX75796.1;KOX71458.1;KOX71982.1;KOX78323.1;KOX71192.1;KOX76788.1;KOX79885.1;KOX73294.1;KOX68049.1;KOX79001.1;KOX78842.1;KOX79122.1;KOX78710.1;KOX77775.1;KOX79217.1 Reactome: R-HSA-5654719 SHC-mediated cascade:FGFR4 1 KOX81204.1 KEGG: 00970+6.1.1.17 Aminoacyl-tRNA biosynthesis 2 KOX76511.1;KOX68068.1 MetaCyc: PWY-4321 L-glutamate degradation IV 1 KOX75380.1 KEGG: 00650+2.3.3.10 Butanoate metabolism 1 KOX70405.1 KEGG: 00511+3.2.1.24 Other glycan degradation 1 KOX74960.1 Reactome: R-HSA-2408557 Selenocysteine synthesis 79 KOX80864.1;KOX77016.1;KOX71651.1;KOX75227.1;KOX67361.1;KOX73344.1;KOX79160.1;KOX72904.1;KOX67237.1;KOX75432.1;KOX75945.1;KOX72125.1;KOX79433.1;KOX79738.1;KOX78568.1;KOX76900.1;KOX70024.1;KOX72105.1;KOX77134.1;KOX73982.1;KOX74668.1;KOX72644.1;KOX67280.1;KOX79914.1;KOX74170.1;KOX69807.1;KOX81388.1;KOX74407.1;KOX68431.1;KOX71988.1;KOX77911.1;KOX74637.1;KOX71077.1;KOX72185.1;KOX75483.1;KOX76065.1;KOX75797.1;KOX74357.1;KOX75024.1;KOX81215.1;KOX78350.1;KOX72660.1;KOX70147.1;KOX67698.1;KOX79430.1;KOX67935.1;KOX81212.1;KOX79611.1;KOX72330.1;KOX77188.1;KOX75283.1;KOX70176.1;KOX67699.1;KOX75143.1;KOX67229.1;KOX71403.1;KOX78800.1;KOX70724.1;KOX67795.1;KOX71471.1;KOX71394.1;KOX73308.1;KOX72074.1;KOX67807.1;KOX75958.1;KOX67227.1;KOX78826.1;KOX73120.1;KOX73889.1;KOX68042.1;KOX78289.1;KOX74804.1;KOX72747.1;KOX73450.1;KOX70874.1;KOX75358.1;KOX68744.1;KOX68107.1;KOX78670.1 Reactome: R-HSA-8865999 MET activates PTPN11 1 KOX81204.1 Reactome: R-HSA-70171 Glycolysis 15 KOX67171.1;KOX67919.1;KOX74975.1;KOX72415.1;KOX72508.1;KOX76361.1;KOX80688.1;KOX67942.1;KOX76362.1;KOX72507.1;KOX74974.1;KOX81104.1;KOX72065.1;KOX67867.1;KOX67203.1 Reactome: R-HSA-5632968 Defective Mismatch Repair Associated With MSH6 2 KOX70744.1;KOX68230.1 KEGG: 00401+2.6.1.1 Novobiocin biosynthesis 2 KOX79912.1;KOX71428.1 KEGG: 00500+2.4.1.18 Starch and sucrose metabolism 2 KOX68382.1;KOX70625.1 MetaCyc: PWY-4261 Glycerol degradation I 7 KOX80352.1;KOX78959.1;KOX68683.1;KOX74206.1;KOX80353.1;KOX70335.1;KOX71603.1 Reactome: R-HSA-4411364 Binding of TCF/LEF:CTNNB1 to target gene promoters 1 KOX67626.1 Reactome: R-HSA-5358752 T41 mutants of beta-catenin aren't phosphorylated 5 KOX76312.1;KOX73320.1;KOX71037.1;KOX75788.1;KOX69536.1 Reactome: R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling 42 KOX71606.1;KOX72468.1;KOX78268.1;KOX80582.1;KOX79433.1;KOX74924.1;KOX69688.1;KOX75984.1;KOX74910.1;KOX73209.1;KOX74011.1;KOX79430.1;KOX76879.1;KOX78266.1;KOX70598.1;KOX72411.1;KOX68314.1;KOX76009.1;KOX70009.1;KOX67229.1;KOX76416.1;KOX73060.1;KOX80008.1;KOX79626.1;KOX68215.1;KOX75968.1;KOX70760.1;KOX68748.1;KOX69333.1;KOX69414.1;KOX78273.1;KOX70419.1;KOX72105.1;KOX79601.1;KOX79230.1;KOX72982.1;KOX80285.1;KOX77271.1;KOX79363.1;KOX70383.1;KOX78786.1;KOX68313.1 Reactome: R-HSA-1482922 Acyl chain remodelling of PI 5 KOX75783.1;KOX69497.1;KOX69576.1;KOX79218.1;KOX72448.1 MetaCyc: PWY-7888 Trna-uridine 2-thiolation (cytoplasmic) 1 KOX71948.1 Reactome: R-HSA-166166 MyD88-independent TLR4 cascade 1 KOX68495.1 MetaCyc: PWY-6700 Queuosine biosynthesis I (de novo) 2 KOX77698.1;KOX80753.1 Reactome: R-HSA-9614399 Regulation of localization of FOXO transcription factors 2 KOX68841.1;KOX72400.1 Reactome: R-HSA-6802952 Signaling by BRAF and RAF fusions 9 KOX76248.1;KOX75579.1;KOX68226.1;KOX79918.1;KOX79143.1;KOX68500.1;KOX76762.1;KOX68521.1;KOX70251.1 KEGG: 00640+6.4.1.2 Propanoate metabolism 1 KOX70011.1 MetaCyc: PWY-6333 Acetaldehyde biosynthesis I 1 KOX67600.1 Reactome: R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition 5 KOX81403.1;KOX71188.1;KOX76312.1;KOX79735.1;KOX72538.1 MetaCyc: PWY-6952 Glycerophosphodiester degradation 1 KOX78959.1 KEGG: 00240+2.1.1.45 Pyrimidine metabolism 1 KOX71982.1 MetaCyc: PWY-7394 Urate conversion to allantoin II 1 KOX78431.1 KEGG: 00480+4.3.2.7 Glutathione metabolism 2 KOX72668.1;KOX79873.1 MetaCyc: PWY-7210 Pyrimidine deoxyribonucleotides biosynthesis from CTP 9 KOX74853.1;KOX76865.1;KOX79885.1;KOX78158.1;KOX71982.1;KOX72820.1;KOX78412.1;KOX79122.1;KOX71458.1 Reactome: R-HSA-4641258 Degradation of DVL 40 KOX72105.1;KOX70419.1;KOX79601.1;KOX79230.1;KOX72982.1;KOX71684.1;KOX79363.1;KOX77271.1;KOX70383.1;KOX68313.1;KOX78786.1;KOX80008.1;KOX79626.1;KOX75968.1;KOX70760.1;KOX69333.1;KOX68748.1;KOX69414.1;KOX78273.1;KOX76879.1;KOX78266.1;KOX79430.1;KOX70598.1;KOX72411.1;KOX68314.1;KOX70009.1;KOX76009.1;KOX73060.1;KOX76416.1;KOX67229.1;KOX71606.1;KOX78268.1;KOX72468.1;KOX80582.1;KOX79433.1;KOX74924.1;KOX74910.1;KOX75984.1;KOX73209.1;KOX74011.1 MetaCyc: PWY-6936 Seleno-amino acid biosynthesis (plants) 1 KOX80071.1 Reactome: R-HSA-1369007 Mitochondrial ABC transporters 1 KOX74318.1 Reactome: R-HSA-5467333 APC truncation mutants are not K63 polyubiquitinated 2 KOX73320.1;KOX75788.1 Reactome: R-HSA-113501 Inhibition of replication initiation of damaged DNA by RB1/E2F1 7 KOX81161.1;KOX78132.1;KOX78863.1;KOX76312.1;KOX80899.1;KOX79678.1;KOX69330.1 Reactome: R-HSA-2206296 MPS II - Hunter syndrome 1 KOX81256.1 Reactome: R-HSA-2428928 IRS-related events triggered by IGF1R 1 KOX72579.1 KEGG: 00740+2.7.1.26 Riboflavin metabolism 1 KOX78122.1 Reactome: R-HSA-111447 Activation of BAD and translocation to mitochondria 3 KOX72400.1;KOX67865.1;KOX69543.1 MetaCyc: PWY-6351 D-myo-inositol (1,4,5)-trisphosphate biosynthesis 6 KOX74728.1;KOX79807.1;KOX76348.1;KOX74989.1;KOX75330.1;KOX71582.1 KEGG: 05170+2.7.11.1 Human immunodeficiency virus 1 infection 40 KOX74479.1;KOX68521.1;KOX77506.1;KOX79033.1;KOX68566.1;KOX79039.1;KOX70561.1;KOX77803.1;KOX71595.1;KOX73362.1;KOX79166.1;KOX73724.1;KOX79522.1;KOX78362.1;KOX68084.1;KOX68654.1;KOX73800.1;KOX68647.1;KOX74477.1;KOX78509.1;KOX77364.1;KOX78841.1;KOX81246.1;KOX76214.1;KOX68054.1;KOX71579.1;KOX69619.1;KOX79817.1;KOX79675.1;KOX77898.1;KOX72201.1;KOX74186.1;KOX70861.1;KOX79935.1;KOX70676.1;KOX76221.1;KOX73463.1;KOX72400.1;KOX79225.1;KOX69995.1 Reactome: R-HSA-2179392 EGFR Transactivation by Gastrin 1 KOX81204.1 KEGG: 04070+3.1.3.64 Phosphatidylinositol signaling system 1 KOX71993.1 Reactome: R-HSA-446210 Synthesis of UDP-N-acetyl-glucosamine 4 KOX74440.1;KOX77757.1;KOX72719.1;KOX68219.1 MetaCyc: PWY-5133 Colupulone and cohumulone biosynthesis 1 KOX74892.1 Reactome: R-HSA-2173788 Downregulation of TGF-beta receptor signaling 10 KOX79433.1;KOX69303.1;KOX71725.1;KOX77551.1;KOX74896.1;KOX67229.1;KOX79430.1;KOX72105.1;KOX69703.1;KOX80322.1 KEGG: 00330+2.6.1.13 Arginine and proline metabolism 2 KOX79798.1;KOX79797.1 Reactome: R-HSA-156584 Cytosolic sulfonation of small molecules 1 KOX76592.1 Reactome: R-HSA-73863 RNA Polymerase I Transcription Termination 21 KOX67437.1;KOX77626.1;KOX74030.1;KOX69540.1;KOX70030.1;KOX81203.1;KOX73198.1;KOX72899.1;KOX69719.1;KOX74919.1;KOX77063.1;KOX71263.1;KOX79649.1;KOX81200.1;KOX68859.1;KOX72538.1;KOX73785.1;KOX72380.1;KOX81403.1;KOX77062.1;KOX69897.1 KEGG: 00562+2.7.1.153 Inositol phosphate metabolism 1 KOX79243.1 Reactome: R-HSA-1295596 Spry regulation of FGF signaling 7 KOX68500.1;KOX67229.1;KOX81204.1;KOX79430.1;KOX79433.1;KOX72105.1;KOX76312.1 KEGG: 00770+6.3.2.5 Pantothenate and CoA biosynthesis 1 KOX72192.1 Reactome: R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) 18 KOX76684.1;KOX77330.1;KOX67229.1;KOX76210.1;KOX73267.1;KOX72154.1;KOX79430.1;KOX72105.1;KOX71898.1;KOX68500.1;KOX74217.1;KOX79433.1;KOX72749.1;KOX74256.1;KOX71992.1;KOX74214.1;KOX79389.1;KOX73517.1 KEGG: 00600+3.1.4.12 Sphingolipid metabolism 1 KOX68502.1 MetaCyc: PWY-5963 Thio-molybdenum cofactor biosynthesis 1 KOX76132.1 Reactome: R-HSA-2426168 Activation of gene expression by SREBF (SREBP) 11 KOX73868.1;KOX77410.1;KOX68963.1;KOX70146.1;KOX74904.1;KOX78052.1;KOX70011.1;KOX69550.1;KOX69440.1;KOX76309.1;KOX73549.1 Reactome: R-HSA-5579006 Defective GSS causes Glutathione synthetase deficiency (GSS deficiency) 1 KOX76540.1 Reactome: R-HSA-2197563 NOTCH2 intracellular domain regulates transcription 1 KOX71242.1 KEGG: 00564+2.7.8.11 Glycerophospholipid metabolism 1 KOX76348.1 Reactome: R-HSA-451308 Activation of Ca-permeable Kainate Receptor 1 KOX78706.1 MetaCyc: PWY-6289 Petrobactin biosynthesis 1 KOX75794.1 Reactome: R-HSA-1650814 Collagen biosynthesis and modifying enzymes 8 KOX75660.1;KOX74957.1;KOX76649.1;KOX71490.1;KOX71492.1;KOX75715.1;KOX75270.1;KOX75720.1 Reactome: R-HSA-6783310 Fanconi Anemia Pathway 23 KOX80991.1;KOX76250.1;KOX73030.1;KOX72105.1;KOX79430.1;KOX67299.1;KOX76254.1;KOX79742.1;KOX80287.1;KOX70402.1;KOX67781.1;KOX78796.1;KOX70794.1;KOX67294.1;KOX79623.1;KOX72862.1;KOX72417.1;KOX67229.1;KOX71272.1;KOX70000.1;KOX70085.1;KOX79433.1;KOX79522.1 Reactome: R-HSA-5368598 Negative regulation of TCF-dependent signaling by DVL-interacting proteins 1 KOX71684.1 Reactome: R-HSA-426496 Post-transcriptional silencing by small RNAs 3 KOX68332.1;KOX67889.1;KOX74580.1 Reactome: R-HSA-416993 Trafficking of GluR2-containing AMPA receptors 6 KOX76387.1;KOX74480.1;KOX68797.1;KOX68045.1;KOX69299.1;KOX79275.1 Reactome: R-HSA-6785631 ERBB2 Regulates Cell Motility 2 KOX72629.1;KOX72781.1 MetaCyc: PWY-5873 Ubiquinol-7 biosynthesis (eukaryotic) 3 KOX77776.1;KOX72023.1;KOX70323.1 Reactome: R-HSA-2453902 The canonical retinoid cycle in rods (twilight vision) 1 KOX78431.1 MetaCyc: PWY-8055 Palmitoyl ethanolamide biosynthesis 8 KOX80284.1;KOX80280.1;KOX76514.1;KOX77858.1;KOX79114.1;KOX67863.1;KOX67923.1;KOX75990.1 MetaCyc: PWY-5532 Nucleoside and nucleotide degradation (archaea) 2 KOX78203.1;KOX77619.1 Reactome: R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 29 KOX73198.1;KOX81203.1;KOX77063.1;KOX69719.1;KOX74919.1;KOX81398.1;KOX71842.1;KOX67200.1;KOX71518.1;KOX77418.1;KOX70044.1;KOX69540.1;KOX74030.1;KOX77626.1;KOX68729.1;KOX77334.1;KOX74930.1;KOX74806.1;KOX69085.1;KOX69897.1;KOX68559.1;KOX81403.1;KOX77062.1;KOX72538.1;KOX78263.1;KOX79649.1;KOX71363.1;KOX73785.1;KOX77907.1 MetaCyc: PWY-6922 L-Ndelta-acetylornithine biosynthesis 2 KOX79798.1;KOX79797.1 KEGG: 00310+4.2.1.17 Lysine degradation 1 KOX76405.1 KEGG: 00230+3.5.4.3 Purine metabolism 1 KOX73844.1 MetaCyc: PWY-6737 Starch degradation V 2 KOX80377.1;KOX74487.1 KEGG: 00230+4.6.1.2 Purine metabolism 6 KOX68414.1;KOX70985.1;KOX76795.1;KOX76796.1;KOX71960.1;KOX70464.1 Reactome: R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 17 KOX79196.1;KOX68243.1;KOX67941.1;KOX71786.1;KOX68858.1;KOX68054.1;KOX71763.1;KOX77923.1;KOX78861.1;KOX72024.1;KOX69173.1;KOX74812.1;KOX73599.1;KOX76598.1;KOX67721.1;KOX80977.1;KOX68669.1 KEGG: 00260+2.3.1.29 Glycine, serine and threonine metabolism 1 KOX71147.1 Reactome: R-HSA-5083635 Defective B3GALTL causes Peters-plus syndrome (PpS) 19 KOX72278.1;KOX70980.1;KOX79000.1;KOX68783.1;KOX70747.1;KOX75240.1;KOX72277.1;KOX70799.1;KOX67248.1;KOX71822.1;KOX67449.1;KOX76316.1;KOX70907.1;KOX71782.1;KOX75564.1;KOX72276.1;KOX75881.1;KOX80303.1;KOX70163.1 Reactome: R-HSA-937039 IRAK1 recruits IKK complex 5 KOX74906.1;KOX79433.1;KOX79430.1;KOX72105.1;KOX67229.1 MetaCyc: PWY-5054 D-sorbitol biosynthesis I 1 KOX67919.1 Reactome: R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 96 KOX73120.1;KOX78826.1;KOX74044.1;KOX78116.1;KOX67227.1;KOX77318.1;KOX73889.1;KOX77319.1;KOX74804.1;KOX78289.1;KOX73450.1;KOX68042.1;KOX78670.1;KOX75358.1;KOX70874.1;KOX68107.1;KOX79860.1;KOX68744.1;KOX79611.1;KOX72330.1;KOX77750.1;KOX67935.1;KOX79069.1;KOX81212.1;KOX79430.1;KOX70147.1;KOX67698.1;KOX69831.1;KOX67699.1;KOX71358.1;KOX67682.1;KOX67229.1;KOX71403.1;KOX75143.1;KOX77188.1;KOX70176.1;KOX71394.1;KOX71471.1;KOX78800.1;KOX67795.1;KOX70724.1;KOX72074.1;KOX73308.1;KOX75958.1;KOX67807.1;KOX72644.1;KOX74668.1;KOX67280.1;KOX77134.1;KOX76312.1;KOX72105.1;KOX73982.1;KOX74407.1;KOX81388.1;KOX74170.1;KOX79914.1;KOX69807.1;KOX77911.1;KOX74637.1;KOX71605.1;KOX68431.1;KOX71988.1;KOX81215.1;KOX72660.1;KOX78350.1;KOX71077.1;KOX75483.1;KOX76065.1;KOX72185.1;KOX75024.1;KOX74357.1;KOX79166.1;KOX75797.1;KOX71651.1;KOX75227.1;KOX80864.1;KOX73371.1;KOX77016.1;KOX73344.1;KOX79160.1;KOX68575.1;KOX74556.1;KOX67361.1;KOX75432.1;KOX75336.1;KOX74909.1;KOX75945.1;KOX72125.1;KOX72904.1;KOX67237.1;KOX70024.1;KOX74908.1;KOX79738.1;KOX79433.1;KOX78568.1;KOX76900.1 Reactome: R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin 48 KOX73209.1;KOX74011.1;KOX74924.1;KOX79433.1;KOX72749.1;KOX75984.1;KOX74910.1;KOX71992.1;KOX80582.1;KOX71606.1;KOX79389.1;KOX72468.1;KOX78268.1;KOX76684.1;KOX67229.1;KOX76416.1;KOX73060.1;KOX76009.1;KOX70009.1;KOX70598.1;KOX72154.1;KOX72411.1;KOX68314.1;KOX79430.1;KOX76879.1;KOX78266.1;KOX69414.1;KOX78273.1;KOX68748.1;KOX69333.1;KOX74256.1;KOX75968.1;KOX70760.1;KOX80008.1;KOX79626.1;KOX70383.1;KOX78786.1;KOX68313.1;KOX72982.1;KOX76210.1;KOX79363.1;KOX77271.1;KOX73267.1;KOX79230.1;KOX70419.1;KOX72105.1;KOX79601.1;KOX71898.1 KEGG: 00860+4.2.1.24 Porphyrin and chlorophyll metabolism 1 KOX79366.1 Reactome: R-HSA-982772 Growth hormone receptor signaling 3 KOX67619.1;KOX68500.1;KOX69723.1 KEGG: 04070+2.7.4.24+2.7.4.21 Phosphatidylinositol signaling system 2 KOX81239.1;KOX81238.1 KEGG: 00650+4.2.1.17 Butanoate metabolism 1 KOX76405.1 KEGG: 00520+1.1.1.271 Amino sugar and nucleotide sugar metabolism 1 KOX72980.1 Reactome: R-HSA-5576892 Phase 0 - rapid depolarisation 8 KOX69774.1;KOX71756.1;KOX68226.1;KOX79241.1;KOX69225.1;KOX70317.1;KOX70316.1;KOX68791.1 Reactome: R-HSA-1912420 Pre-NOTCH Processing in Golgi 2 KOX76050.1;KOX69108.1 Reactome: R-HSA-5625740 RHO GTPases activate PKNs 4 KOX69543.1;KOX78362.1;KOX77703.1;KOX67865.1 Reactome: R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 5 KOX67775.1;KOX76191.1;KOX67931.1;KOX77097.1;KOX78779.1 MetaCyc: PWY-7141 (3S)-linalool biosynthesis 1 KOX72808.1 MetaCyc: PWY-7920 Complex N-linked glycan biosynthesis (plants) 1 KOX79732.1 MetaCyc: PWY-5663 Erythro-tetrahydrobiopterin biosynthesis I 1 KOX73788.1 MetaCyc: PWY-7894 Procollagen hydroxylation and glycosylation 2 KOX71492.1;KOX71490.1 Reactome: R-HSA-209968 Thyroxine biosynthesis 2 KOX68568.1;KOX71116.1 KEGG: 00052+2.7.1.11 Galactose metabolism 1 KOX67867.1 Reactome: R-HSA-1362277 Transcription of E2F targets under negative control by DREAM complex 8 KOX73662.1;KOX78024.1;KOX76415.1;KOX70054.1;KOX70592.1;KOX80899.1;KOX74615.1;KOX68519.1 Reactome: R-HSA-4793954 Defective MOGS causes MOGS-CDG (CDG-2b) 1 KOX72748.1 KEGG: 00950+1.14.16.2 Isoquinoline alkaloid biosynthesis 1 KOX71846.1 Reactome: R-HSA-5632681 Ligand-receptor interactions 2 KOX80704.1;KOX75983.1 Reactome: R-HSA-8863795 Downregulation of ERBB2 signaling 7 KOX67229.1;KOX77551.1;KOX73791.1;KOX72629.1;KOX72105.1;KOX79433.1;KOX79430.1 MetaCyc: PWY-6724 Starch degradation II 1 KOX74487.1 Reactome: R-HSA-1989781 PPARA activates gene expression 42 KOX70063.1;KOX70422.1;KOX77410.1;KOX68771.1;KOX78565.1;KOX74904.1;KOX80339.1;KOX68963.1;KOX71407.1;KOX70325.1;KOX75722.1;KOX70293.1;KOX76309.1;KOX71620.1;KOX70405.1;KOX75721.1;KOX67402.1;KOX79974.1;KOX74616.1;KOX71059.1;KOX69665.1;KOX76194.1;KOX79676.1;KOX72486.1;KOX67461.1;KOX68772.1;KOX70975.1;KOX73868.1;KOX72224.1;KOX75944.1;KOX80746.1;KOX78052.1;KOX72755.1;KOX70259.1;KOX77181.1;KOX79845.1;KOX71552.1;KOX68229.1;KOX74031.1;KOX71879.1;KOX74632.1;KOX76141.1 Reactome: R-HSA-163841 Gamma carboxylation, hypusine formation and arylsulfatase activation 1 KOX75593.1 Reactome: R-HSA-194840 Rho GTPase cycle 41 KOX79097.1;KOX73438.1;KOX68811.1;KOX70636.1;KOX80130.1;KOX69925.1;KOX68654.1;KOX73383.1;KOX70824.1;KOX81333.1;KOX71878.1;KOX70014.1;KOX67850.1;KOX76827.1;KOX80890.1;KOX70393.1;KOX71583.1;KOX78917.1;KOX79855.1;KOX71884.1;KOX78779.1;KOX71191.1;KOX67328.1;KOX74663.1;KOX73980.1;KOX74133.1;KOX73861.1;KOX70804.1;KOX75106.1;KOX67551.1;KOX68807.1;KOX67890.1;KOX76191.1;KOX74173.1;KOX72761.1;KOX79248.1;KOX75499.1;KOX73859.1;KOX70004.1;KOX78997.1;KOX69686.1 MetaCyc: PWY-5188 Tetrapyrrole biosynthesis I (from glutamate) 5 KOX68068.1;KOX76511.1;KOX73781.1;KOX79366.1;KOX78820.1 Reactome: R-HSA-450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 12 KOX70791.1;KOX70145.1;KOX75605.1;KOX79092.1;KOX68794.1;KOX68192.1;KOX71022.1;KOX71950.1;KOX69500.1;KOX68469.1;KOX79938.1;KOX76988.1 KEGG: 00592+1.3.3.6 alpha-Linolenic acid metabolism 2 KOX71616.1;KOX73119.1 KEGG: 00785+6.3.1.20 Lipoic acid metabolism 1 KOX71375.1 Reactome: R-HSA-8866423 VLDL assembly 9 KOX73736.1;KOX73734.1;KOX69335.1;KOX73735.1;KOX73976.1;KOX68248.1;KOX73997.1;KOX80996.1;KOX74771.1 Reactome: R-HSA-167044 Signalling to RAS 2 KOX81204.1;KOX67779.1 Reactome: R-HSA-163765 ChREBP activates metabolic gene expression 5 KOX74316.1;KOX73549.1;KOX70011.1;KOX69550.1;KOX80707.1 MetaCyc: PWY-7723 Bacterial bioluminescence 2 KOX73549.1;KOX69550.1 Reactome: R-HSA-77289 Mitochondrial Fatty Acid Beta-Oxidation 2 KOX68433.1;KOX69439.1 MetaCyc: PWY-6519 8-amino-7-oxononanoate biosynthesis I 2 KOX73549.1;KOX69550.1 KEGG: 04660+2.7.10.2 T cell receptor signaling pathway 5 KOX80895.1;KOX78564.1;KOX72190.1;KOX73463.1;KOX72079.1 Reactome: R-HSA-389513 CTLA4 inhibitory signaling 4 KOX71037.1;KOX69536.1;KOX72400.1;KOX76312.1 Reactome: R-HSA-445355 Smooth Muscle Contraction 8 KOX71960.1;KOX69310.1;KOX76795.1;KOX76719.1;KOX70464.1;KOX76796.1;KOX76718.1;KOX79918.1 Reactome: R-HSA-936964 Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon 6 KOX68495.1;KOX67229.1;KOX72105.1;KOX70261.1;KOX79433.1;KOX79430.1 KEGG: 00473+5.1.1.1 D-Alanine metabolism 1 KOX79794.1 Reactome: R-HSA-179409 APC-Cdc20 mediated degradation of Nek2A 13 KOX72105.1;KOX79389.1;KOX79430.1;KOX71898.1;KOX73267.1;KOX71992.1;KOX72154.1;KOX76210.1;KOX79433.1;KOX74256.1;KOX72749.1;KOX76684.1;KOX67229.1 Reactome: R-HSA-3238698 WNT ligand biogenesis and trafficking 11 KOX74260.1;KOX76787.1;KOX74858.1;KOX77371.1;KOX73809.1;KOX71666.1;KOX74261.1;KOX73031.1;KOX77372.1;KOX71425.1;KOX76015.1 KEGG: 00330+2.5.1.22 Arginine and proline metabolism 1 KOX80905.1 MetaCyc: PWY-2261 Ascorbate glutathione cycle 2 KOX71878.1;KOX69433.1 MetaCyc: PWY-6545 Pyrimidine deoxyribonucleotides de novo biosynthesis III 9 KOX74853.1;KOX76865.1;KOX80826.1;KOX79122.1;KOX71458.1;KOX69334.1;KOX78412.1;KOX79885.1;KOX78158.1 KEGG: 00760+3.6.1.9 Nicotinate and nicotinamide metabolism 2 KOX80826.1;KOX69334.1 Reactome: R-HSA-6803529 FGFR2 alternative splicing 13 KOX77062.1;KOX74908.1;KOX77063.1;KOX81203.1;KOX74806.1;KOX73198.1;KOX68207.1;KOX77626.1;KOX74909.1;KOX70044.1;KOX79649.1;KOX77418.1;KOX67200.1 Reactome: R-HSA-1475029 Reversible hydration of carbon dioxide 2 KOX68932.1;KOX80775.1 MetaCyc: PWY-5265 Peptidoglycan biosynthesis II (staphylococci) 1 KOX77790.1 KEGG: 00780+1.1.1.100+4.2.1.59+2.3.1.41 Biotin metabolism 2 KOX69550.1;KOX73549.1 KEGG: 00790+3.4.19.9 Folate biosynthesis 1 KOX80762.1 KEGG: 00230+1.17.1.4+1.17.3.2 Purine metabolism 1 KOX71781.1 Reactome: R-HSA-3656237 Defective EXT2 causes exostoses 2 6 KOX80364.1;KOX76492.1;KOX73118.1;KOX74836.1;KOX77892.1;KOX80363.1 Reactome: R-HSA-76005 Response to elevated platelet cytosolic Ca2+ 1 KOX79275.1 Reactome: R-HSA-72187 mRNA 3'-end processing 31 KOX71803.1;KOX67341.1;KOX67153.1;KOX73449.1;KOX69435.1;KOX74745.1;KOX68575.1;KOX81159.1;KOX68477.1;KOX74386.1;KOX72220.1;KOX79349.1;KOX72752.1;KOX73304.1;KOX74909.1;KOX75893.1;KOX77867.1;KOX75336.1;KOX71605.1;KOX74624.1;KOX74908.1;KOX72920.1;KOX73274.1;KOX73851.1;KOX79860.1;KOX79897.1;KOX75816.1;KOX71437.1;KOX68896.1;KOX77767.1;KOX75678.1 Reactome: R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 41 KOX72468.1;KOX78268.1;KOX71606.1;KOX80582.1;KOX75984.1;KOX74910.1;KOX74924.1;KOX79433.1;KOX74011.1;KOX73209.1;KOX72082.1;KOX79430.1;KOX78266.1;KOX76879.1;KOX72411.1;KOX68314.1;KOX70598.1;KOX76009.1;KOX70009.1;KOX76416.1;KOX67229.1;KOX73060.1;KOX79626.1;KOX80008.1;KOX70760.1;KOX75968.1;KOX68748.1;KOX69333.1;KOX78273.1;KOX69414.1;KOX79601.1;KOX70419.1;KOX72105.1;KOX79230.1;KOX77271.1;KOX79363.1;KOX67622.1;KOX72982.1;KOX78786.1;KOX68313.1;KOX70383.1 Reactome: R-HSA-1250196 SHC1 events in ERBB2 signaling 2 KOX81204.1;KOX72629.1 KEGG: 00260+1.8.1.4 Glycine, serine and threonine metabolism 1 KOX75086.1 KEGG: 00010+4.1.2.13 Glycolysis / Gluconeogenesis 2 KOX76361.1;KOX76362.1 Reactome: R-HSA-9033500 TYSND1 cleaves peroxisomal proteins 2 KOX77488.1;KOX67833.1 Reactome: R-HSA-4755583 Defective DOLK causes DOLK-CDG (CDG-1m) 1 KOX67918.1 KEGG: 00790+2.8.1.9 Folate biosynthesis 1 KOX76132.1 Reactome: R-HSA-114508 Effects of PIP2 hydrolysis 6 KOX79421.1;KOX76676.1;KOX68067.1;KOX73249.1;KOX77054.1;KOX73812.1 Reactome: R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence 8 KOX74812.1;KOX74214.1;KOX68243.1;KOX80977.1;KOX71786.1;KOX68054.1;KOX74217.1;KOX77330.1 Reactome: R-HSA-1474228 Degradation of the extracellular matrix 7 KOX70021.1;KOX79435.1;KOX81397.1;KOX69792.1;KOX71497.1;KOX76464.1;KOX75270.1 KEGG: 00900+5.3.3.2 Terpenoid backbone biosynthesis 1 KOX74855.1 Reactome: R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling 2 KOX81204.1;KOX70804.1 Reactome: R-HSA-8931987 RUNX1 regulates estrogen receptor mediated transcription 1 KOX79878.1 KEGG: 00380+2.3.1.61 Tryptophan metabolism 1 KOX70384.1 KEGG: 00130+1.17.4.4 Ubiquinone and other terpenoid-quinone biosynthesis 1 KOX79863.1 MetaCyc: PWY-7818 Type IV lipoteichoic acid biosynthesis (S. pneumoniae) 1 KOX67207.1 KEGG: 00983+2.7.4.6 Drug metabolism - other enzymes 4 KOX78158.1;KOX76865.1;KOX78412.1;KOX71458.1 Reactome: R-HSA-2206307 MPS IIIA - Sanfilippo syndrome A 1 KOX72773.1 MetaCyc: PWY-6999 Theophylline degradation 1 KOX71781.1 Reactome: R-HSA-73728 RNA Polymerase I Promoter Opening 3 KOX77330.1;KOX74214.1;KOX74217.1 Reactome: R-HSA-5673000 RAF activation 5 KOX80917.1;KOX71037.1;KOX69536.1;KOX76312.1;KOX68226.1 Reactome: R-HSA-420499 Class C/3 (Metabotropic glutamate/pheromone receptors) 7 KOX73290.1;KOX79450.1;KOX72109.1;KOX67188.1;KOX70661.1;KOX70660.1;KOX70662.1 Reactome: R-HSA-5658034 HHAT G278V abrogates palmitoylation of Hh-Np 1 KOX80704.1 Reactome: R-HSA-71384 Ethanol oxidation 3 KOX67600.1;KOX77804.1;KOX69522.1 KEGG: 00790+2.8.1.12 Folate biosynthesis 1 KOX71043.1 KEGG: 00710+5.3.1.6 Carbon fixation in photosynthetic organisms 1 KOX80223.1 Reactome: R-HSA-5689896 Ovarian tumor domain proteases 10 KOX79430.1;KOX72105.1;KOX78521.1;KOX81261.1;KOX79433.1;KOX75788.1;KOX68925.1;KOX73320.1;KOX67229.1;KOX71940.1 KEGG: 00565+3.1.1.4 Ether lipid metabolism 10 KOX78316.1;KOX79218.1;KOX69497.1;KOX78399.1;KOX77917.1;KOX72448.1;KOX70330.1;KOX78275.1;KOX69576.1;KOX75783.1 MetaCyc: PWY-5892 Menaquinol-12 biosynthesis 1 KOX75964.1 KEGG: 00910+6.3.1.2 Nitrogen metabolism 1 KOX75490.1 Reactome: R-HSA-5602680 MyD88 deficiency (TLR5) 1 KOX68497.1 Reactome: R-HSA-880009 Interconversion of 2-oxoglutarate and 2-hydroxyglutarate 1 KOX72506.1 MetaCyc: PWY-2301 Myo-inositol biosynthesis 4 KOX71857.1;KOX75545.1;KOX75546.1;KOX68055.1 Reactome: R-HSA-9033241 Peroxisomal protein import 25 KOX79433.1;KOX77488.1;KOX80501.1;KOX73119.1;KOX73332.1;KOX72741.1;KOX76478.1;KOX81337.1;KOX76704.1;KOX77090.1;KOX69300.1;KOX69757.1;KOX72779.1;KOX80585.1;KOX77088.1;KOX69613.1;KOX69329.1;KOX67229.1;KOX80043.1;KOX73333.1;KOX75952.1;KOX67833.1;KOX79430.1;KOX72105.1;KOX71616.1 KEGG: 00250+6.3.5.5 Alanine, aspartate and glutamate metabolism 1 KOX80440.1 MetaCyc: PWY-7255 Ergothioneine biosynthesis I (bacteria) 1 KOX78147.1 KEGG: 00710+1.2.1.12 Carbon fixation in photosynthetic organisms 1 KOX72508.1 KEGG: 00051+5.3.1.1 Fructose and mannose metabolism 1 KOX67171.1 Reactome: R-HSA-73762 RNA Polymerase I Transcription Initiation 24 KOX77063.1;KOX71263.1;KOX72899.1;KOX69719.1;KOX74919.1;KOX73198.1;KOX70030.1;KOX81203.1;KOX77626.1;KOX74030.1;KOX69540.1;KOX67437.1;KOX69897.1;KOX81403.1;KOX77062.1;KOX72380.1;KOX70373.1;KOX73785.1;KOX67158.1;KOX68859.1;KOX72538.1;KOX77394.1;KOX79649.1;KOX81200.1 Reactome: R-HSA-2980766 Nuclear Envelope Breakdown 1 KOX81389.1 Reactome: R-HSA-71064 Lysine catabolism 2 KOX75086.1;KOX70384.1 KEGG: 00130+4.1.1.90 Ubiquinone and other terpenoid-quinone biosynthesis 1 KOX69948.1 MetaCyc: PWY-7416 Phospholipid remodeling (phosphatidylcholine, yeast) 10 KOX77917.1;KOX70330.1;KOX72448.1;KOX69576.1;KOX78275.1;KOX75783.1;KOX78316.1;KOX79218.1;KOX78399.1;KOX69497.1 MetaCyc: PWY-5101 L-isoleucine biosynthesis II 1 KOX72274.1 MetaCyc: PWY-8041 Ultra-long-chain fatty acid biosynthesis 21 KOX67486.1;KOX78650.1;KOX78662.1;KOX78657.1;KOX79701.1;KOX77795.1;KOX78654.1;KOX67350.1;KOX68696.1;KOX80068.1;KOX75202.1;KOX78659.1;KOX78660.1;KOX78651.1;KOX78653.1;KOX68278.1;KOX74597.1;KOX78236.1;KOX78713.1;KOX73201.1;KOX68279.1 Reactome: R-HSA-5676590 NIK-->noncanonical NF-kB signaling 42 KOX72982.1;KOX80285.1;KOX79363.1;KOX77271.1;KOX70383.1;KOX78786.1;KOX68313.1;KOX70419.1;KOX72105.1;KOX79601.1;KOX79230.1;KOX68748.1;KOX69333.1;KOX69414.1;KOX78273.1;KOX80008.1;KOX79626.1;KOX68215.1;KOX75968.1;KOX70760.1;KOX76009.1;KOX70009.1;KOX67229.1;KOX76416.1;KOX73060.1;KOX79430.1;KOX78266.1;KOX76879.1;KOX70598.1;KOX72411.1;KOX68314.1;KOX74924.1;KOX69688.1;KOX79433.1;KOX75984.1;KOX74910.1;KOX73209.1;KOX74011.1;KOX71606.1;KOX72468.1;KOX78268.1;KOX80582.1 Reactome: R-HSA-9635465 Suppression of apoptosis 1 KOX68500.1 Reactome: R-HSA-202427 Phosphorylation of CD3 and TCR zeta chains 1 KOX75253.1 Reactome: R-HSA-196783 Coenzyme A biosynthesis 5 KOX72192.1;KOX67569.1;KOX72290.1;KOX75398.1;KOX76985.1 Reactome: R-HSA-111463 SMAC (DIABLO) binds to IAPs 5 KOX78217.1;KOX69899.1;KOX73754.1;KOX78094.1;KOX69910.1 KEGG: 00603+3.2.1.52 Glycosphingolipid biosynthesis - globo and isoglobo series 4 KOX74395.1;KOX74631.1;KOX73530.1;KOX74285.1 KEGG: 00533+2.4.1.68 Glycosaminoglycan biosynthesis - keratan sulfate 1 KOX77864.1 Reactome: R-HSA-5627123 RHO GTPases activate PAKs 2 KOX78779.1;KOX76191.1 KEGG: 00720+2.3.3.8 Carbon fixation pathways in prokaryotes 1 KOX74316.1 Reactome: R-HSA-1855183 Synthesis of IP2, IP, and Ins in the cytosol 10 KOX75106.1;KOX69866.1;KOX74178.1;KOX78498.1;KOX74115.1;KOX68055.1;KOX75546.1;KOX75545.1;KOX71993.1;KOX71857.1 MetaCyc: PWY-6168 Flavin biosynthesis III (fungi) 1 KOX78122.1 KEGG: 00564+2.7.1.32+2.7.1.82 Glycerophospholipid metabolism 1 KOX67207.1 MetaCyc: PWY-5514 UDP-N-acetyl-D-galactosamine biosynthesis II 4 KOX81368.1;KOX74440.1;KOX67919.1;KOX67942.1 Reactome: R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 18 KOX72186.1;KOX80895.1;KOX78779.1;KOX79097.1;KOX74888.1;KOX76112.1;KOX68500.1;KOX76825.1;KOX72811.1;KOX76191.1;KOX80062.1;KOX77415.1;KOX78337.1;KOX69804.1;KOX81204.1;KOX68066.1;KOX74872.1;KOX78334.1 KEGG: 00630+1.11.1.6 Glyoxylate and dicarboxylate metabolism 1 KOX76704.1 KEGG: 00680+1.1.1.95 Methane metabolism 1 KOX74576.1 Reactome: R-HSA-114608 Platelet degranulation 5 KOX79365.1;KOX71944.1;KOX79918.1;KOX71266.1;KOX80468.1 KEGG: 00500+2.4.1.11 Starch and sucrose metabolism 1 KOX72681.1 KEGG: 00500+5.3.1.9 Starch and sucrose metabolism 1 KOX67919.1 MetaCyc: PWY-6958 Icosapentaenoate biosynthesis I (lower eukaryotes) 2 KOX78236.1;KOX79701.1 KEGG: 04070+2.7.1.158 Phosphatidylinositol signaling system 2 KOX81095.1;KOX81098.1 Reactome: R-HSA-6798695 Neutrophil degranulation 94 KOX71867.1;KOX72469.1;KOX74643.1;KOX74910.1;KOX80762.1;KOX75984.1;KOX78431.1;KOX74384.1;KOX80480.1;KOX78268.1;KOX80383.1;KOX79918.1;KOX76416.1;KOX71272.1;KOX71096.1;KOX67259.1;KOX78035.1;KOX73315.1;KOX78341.1;KOX75579.1;KOX72766.1;KOX78266.1;KOX80589.1;KOX77076.1;KOX76704.1;KOX74487.1;KOX69333.1;KOX71685.1;KOX80222.1;KOX70760.1;KOX72546.1;KOX75392.1;KOX68786.1;KOX70253.1;KOX75808.1;KOX68313.1;KOX73754.1;KOX78224.1;KOX75809.1;KOX68214.1;KOX70575.1;KOX73082.1;KOX67723.1;KOX74011.1;KOX70849.1;KOX73209.1;KOX79369.1;KOX69794.1;KOX77910.1;KOX74924.1;KOX75568.1;KOX75409.1;KOX73246.1;KOX76688.1;KOX79366.1;KOX70996.1;KOX67371.1;KOX70411.1;KOX75731.1;KOX76507.1;KOX70009.1;KOX76009.1;KOX72820.1;KOX81363.1;KOX76760.1;KOX67899.1;KOX78203.1;KOX76879.1;KOX78273.1;KOX71979.1;KOX75458.1;KOX69414.1;KOX70021.1;KOX72128.1;KOX74349.1;KOX73869.1;KOX78201.1;KOX80754.1;KOX78850.1;KOX75994.1;KOX68934.1;KOX76903.1;KOX80008.1;KOX78887.1;KOX67635.1;KOX74316.1;KOX68929.1;KOX75253.1;KOX72912.1;KOX67919.1;KOX68049.1;KOX79230.1;KOX69240.1;KOX81109.1 KEGG: 00270+2.1.1.37 Cysteine and methionine metabolism 4 KOX71481.1;KOX77963.1;KOX74005.1;KOX74441.1 MetaCyc: PWY-5079 L-phenylalanine degradation III 1 KOX67600.1 Reactome: R-HSA-3304356 SMAD2/3 Phosphorylation Motif Mutants in Cancer 1 KOX74896.1 Reactome: R-HSA-901042 Calnexin/calreticulin cycle 2 KOX78325.1;KOX69658.1 Reactome: R-HSA-426486 Small interfering RNA (siRNA) biogenesis 6 KOX78743.1;KOX67889.1;KOX68332.1;KOX79620.1;KOX70787.1;KOX74828.1 Reactome: R-HSA-8934903 Receptor Mediated Mitophagy 3 KOX79229.1;KOX79369.1;KOX80344.1 Reactome: R-HSA-9020702 Interleukin-1 signaling 45 KOX69414.1;KOX78273.1;KOX71979.1;KOX69333.1;KOX68748.1;KOX75968.1;KOX70760.1;KOX75998.1;KOX80008.1;KOX79626.1;KOX70383.1;KOX68313.1;KOX78786.1;KOX72982.1;KOX77271.1;KOX79363.1;KOX79230.1;KOX72105.1;KOX70419.1;KOX74906.1;KOX79601.1;KOX73209.1;KOX74011.1;KOX79433.1;KOX74924.1;KOX69688.1;KOX74910.1;KOX75984.1;KOX80582.1;KOX71606.1;KOX78268.1;KOX72468.1;KOX73643.1;KOX73060.1;KOX67229.1;KOX76416.1;KOX70009.1;KOX76009.1;KOX70598.1;KOX68314.1;KOX72411.1;KOX68497.1;KOX76879.1;KOX78266.1;KOX79430.1 KEGG: 00640+2.6.1.19 Propanoate metabolism 1 KOX75380.1 Reactome: R-HSA-2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX) 8 KOX76314.1;KOX70888.1;KOX69991.1;KOX71899.1;KOX81309.1;KOX71712.1;KOX74679.1;KOX70890.1 Reactome: R-HSA-9603505 NTRK3 as a dependence receptor 1 KOX71506.1 MetaCyc: PWY-6471 Peptidoglycan biosynthesis IV (Enterococcus faecium) 1 KOX77790.1 MetaCyc: PWY-5826 Hypoglycin biosynthesis 3 KOX79924.1;KOX71346.1;KOX78785.1 Reactome: R-HSA-5576894 Phase 1 - inactivation of fast Na+ channels 2 KOX70819.1;KOX70822.1 MetaCyc: PWY-8010 L-cysteine biosynthesis IX (Trichomonas vaginalis) 1 KOX74576.1 Reactome: R-HSA-3214842 HDMs demethylate histones 8 KOX74214.1;KOX73732.1;KOX74217.1;KOX77330.1;KOX74003.1;KOX81382.1;KOX73609.1;KOX71511.1 KEGG: 00500+3.6.1.9 Starch and sucrose metabolism 2 KOX80826.1;KOX69334.1 KEGG: 00970+6.1.1.20 Aminoacyl-tRNA biosynthesis 5 KOX72205.1;KOX76349.1;KOX72180.1;KOX72206.1;KOX75798.1 MetaCyc: PWY-7800 Ac/N-end rule pathway 3 KOX79625.1;KOX71937.1;KOX75083.1 Reactome: R-HSA-425381 Bicarbonate transporters 2 KOX70859.1;KOX78417.1 MetaCyc: PWY-7290 Escherichia coli serotype O86 O-antigen biosynthesis 1 KOX71619.1 KEGG: 00970+6.1.1.5 Aminoacyl-tRNA biosynthesis 2 KOX79232.1;KOX67618.1 KEGG: 00052+2.7.7.9 Galactose metabolism 1 KOX67374.1 MetaCyc: PWY-7388 Octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast) 2 KOX73549.1;KOX69550.1 MetaCyc: PWY-5177 Glutaryl-coa degradation 2 KOX75101.1;KOX76405.1 Reactome: R-HSA-3214847 HATs acetylate histones 49 KOX73266.1;KOX70978.1;KOX72073.1;KOX74555.1;KOX69085.1;KOX74214.1;KOX78054.1;KOX73348.1;KOX80586.1;KOX72680.1;KOX77699.1;KOX71241.1;KOX67159.1;KOX73324.1;KOX77330.1;KOX74226.1;KOX78410.1;KOX75067.1;KOX78119.1;KOX69665.1;KOX68729.1;KOX68601.1;KOX68903.1;KOX69059.1;KOX68759.1;KOX74217.1;KOX71724.1;KOX73331.1;KOX79220.1;KOX75848.1;KOX77096.1;KOX78754.1;KOX79025.1;KOX74812.1;KOX73326.1;KOX69820.1;KOX75352.1;KOX67158.1;KOX73830.1;KOX68998.1;KOX77288.1;KOX78767.1;KOX74640.1;KOX79675.1;KOX74602.1;KOX67798.1;KOX80897.1;KOX79622.1;KOX80276.1 Reactome: R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A 48 KOX72468.1;KOX78268.1;KOX71606.1;KOX79389.1;KOX80582.1;KOX71992.1;KOX72749.1;KOX75984.1;KOX74910.1;KOX79433.1;KOX74924.1;KOX74011.1;KOX73209.1;KOX79430.1;KOX76879.1;KOX78266.1;KOX72154.1;KOX72411.1;KOX68314.1;KOX70598.1;KOX76009.1;KOX70009.1;KOX76416.1;KOX67229.1;KOX73060.1;KOX76684.1;KOX79626.1;KOX80008.1;KOX70760.1;KOX75968.1;KOX74256.1;KOX68748.1;KOX69333.1;KOX78273.1;KOX69414.1;KOX79601.1;KOX71898.1;KOX70419.1;KOX72105.1;KOX79230.1;KOX73267.1;KOX79363.1;KOX77271.1;KOX72982.1;KOX76210.1;KOX78786.1;KOX68313.1;KOX70383.1 Reactome: R-HSA-6809371 Formation of the cornified envelope 12 KOX68734.1;KOX69087.1;KOX78516.1;KOX68098.1;KOX68109.1;KOX71607.1;KOX67815.1;KOX72949.1;KOX72947.1;KOX67430.1;KOX67654.1;KOX72864.1 Reactome: R-HSA-8949275 RUNX3 Regulates Immune Response and Cell Migration 1 KOX79878.1 KEGG: 00030+2.7.1.15 Pentose phosphate pathway 1 KOX78189.1 KEGG: 05163+2.7.1.153 Human cytomegalovirus infection 1 KOX79243.1 Reactome: R-HSA-72163 mRNA Splicing - Major Pathway 86 KOX79403.1;KOX70267.1;KOX75678.1;KOX75852.1;KOX78415.1;KOX79860.1;KOX78510.1;KOX77626.1;KOX69604.1;KOX72174.1;KOX78065.1;KOX73198.1;KOX78669.1;KOX71659.1;KOX72432.1;KOX69435.1;KOX77063.1;KOX70045.1;KOX76182.1;KOX73321.1;KOX71743.1;KOX70374.1;KOX68896.1;KOX78050.1;KOX69307.1;KOX75063.1;KOX69494.1;KOX74311.1;KOX67200.1;KOX67341.1;KOX67590.1;KOX67508.1;KOX78408.1;KOX80507.1;KOX77023.1;KOX77020.1;KOX79304.1;KOX79920.1;KOX68599.1;KOX72752.1;KOX71018.1;KOX81295.1;KOX70268.1;KOX81159.1;KOX68848.1;KOX71605.1;KOX73257.1;KOX77840.1;KOX79815.1;KOX74806.1;KOX79897.1;KOX67153.1;KOX77740.1;KOX69886.1;KOX70044.1;KOX71368.1;KOX80923.1;KOX72329.1;KOX79307.1;KOX68671.1;KOX79649.1;KOX80608.1;KOX75336.1;KOX77867.1;KOX71440.1;KOX74909.1;KOX75893.1;KOX77062.1;KOX80307.1;KOX74908.1;KOX71737.1;KOX77418.1;KOX70084.1;KOX68485.1;KOX68675.1;KOX71803.1;KOX74267.1;KOX72220.1;KOX78200.1;KOX79349.1;KOX81203.1;KOX78035.1;KOX79313.1;KOX74386.1;KOX79743.1;KOX68575.1 MetaCyc: PWY-7586 Beta-1,4-d-mannosyl-n-acetyl-d-glucosamine degradation 2 KOX72772.1;KOX74805.1 MetaCyc: PWY-5994 Palmitate biosynthesis (animals and fungi, cytoplasm) 2 KOX69550.1;KOX73549.1 Reactome: R-HSA-69166 Removal of the Flap Intermediate 13 KOX69330.1;KOX78024.1;KOX77326.1;KOX72024.1;KOX70402.1;KOX70179.1;KOX81364.1;KOX77356.1;KOX78863.1;KOX79678.1;KOX78132.1;KOX72417.1;KOX81161.1 KEGG: 00514+2.4.1.255 Other types of O-glycan biosynthesis 1 KOX78410.1 Reactome: R-HSA-75953 RNA Polymerase II Transcription Initiation 29 KOX71363.1;KOX79649.1;KOX72538.1;KOX78263.1;KOX77907.1;KOX73785.1;KOX69085.1;KOX74930.1;KOX74806.1;KOX68559.1;KOX81403.1;KOX77062.1;KOX69897.1;KOX71518.1;KOX77418.1;KOX71842.1;KOX67200.1;KOX68729.1;KOX77334.1;KOX70044.1;KOX69540.1;KOX74030.1;KOX77626.1;KOX81203.1;KOX73198.1;KOX69719.1;KOX74919.1;KOX81398.1;KOX77063.1 MetaCyc: PWY-5664 Erythro-tetrahydrobiopterin biosynthesis II 1 KOX73788.1 MetaCyc: PWY-6883 Pyruvate fermentation to butanol II (engineered) 2 KOX75101.1;KOX76405.1 MetaCyc: PWY-7892 Trna-uridine 2-thiolation and selenation (bacteria) 1 KOX71682.1 MetaCyc: PWY-6829 Trna methylation (yeast) 8 KOX73653.1;KOX79251.1;KOX80212.1;KOX72896.1;KOX67520.1;KOX67568.1;KOX72874.1;KOX71948.1 KEGG: 00565+3.1.3.4 Ether lipid metabolism 2 KOX80284.1;KOX67863.1 Reactome: R-HSA-5218921 VEGFR2 mediated cell proliferation 3 KOX73812.1;KOX78362.1;KOX69748.1 KEGG: 00130+2.1.1.222+2.1.1.64 Ubiquinone and other terpenoid-quinone biosynthesis 1 KOX72023.1 Reactome: R-HSA-8939211 ESR-mediated signaling 3 KOX68500.1;KOX76543.1;KOX74854.1 Reactome: R-HSA-1296052 Ca2+ activated K+ channels 4 KOX75453.1;KOX76457.1;KOX75450.1;KOX76461.1 KEGG: 00250+3.5.1.1 Alanine, aspartate and glutamate metabolism 2 KOX71052.1;KOX72380.1 MetaCyc: PWY-5132 Lupulone and humulone biosynthesis 1 KOX74892.1 Reactome: R-HSA-5619078 Defective SLC35C1 causes congenital disorder of glycosylation 2C (CDG2C) 1 KOX79925.1 MetaCyc: PWY-5874 Heme degradation I 1 KOX70144.1 KEGG: 00510+2.4.1.258 N-Glycan biosynthesis 1 KOX71269.1 KEGG: 00450+4.4.1.13 Selenocompound metabolism 1 KOX80071.1 Reactome: R-HSA-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter 22 KOX81203.1;KOX73198.1;KOX72899.1;KOX77063.1;KOX74448.1;KOX78581.1;KOX70382.1;KOX77626.1;KOX79544.1;KOX77836.1;KOX71970.1;KOX68921.1;KOX76947.1;KOX67791.1;KOX74451.1;KOX77413.1;KOX68645.1;KOX77062.1;KOX81200.1;KOX79649.1;KOX67394.1;KOX77884.1 Reactome: R-HSA-6807505 RNA polymerase II transcribes snRNA genes 42 KOX77836.1;KOX74806.1;KOX69587.1;KOX71507.1;KOX76741.1;KOX69070.1;KOX73198.1;KOX78581.1;KOX77063.1;KOX68573.1;KOX71842.1;KOX70044.1;KOX79544.1;KOX77626.1;KOX74930.1;KOX71123.1;KOX77062.1;KOX76737.1;KOX74908.1;KOX79649.1;KOX79427.1;KOX77907.1;KOX74909.1;KOX71710.1;KOX67799.1;KOX69502.1;KOX78667.1;KOX81203.1;KOX73792.1;KOX75369.1;KOX79919.1;KOX68827.1;KOX81398.1;KOX76735.1;KOX77418.1;KOX71282.1;KOX67200.1;KOX76497.1;KOX81211.1;KOX78143.1;KOX79304.1;KOX78553.1 KEGG: 00970+6.1.1.6 Aminoacyl-tRNA biosynthesis 1 KOX71409.1 MetaCyc: PWY-1861 Formaldehyde assimilation II (assimilatory RuMP Cycle) 5 KOX67867.1;KOX67931.1;KOX80223.1;KOX76362.1;KOX76361.1 KEGG: 00970+6.1.1.2 Aminoacyl-tRNA biosynthesis 2 KOX74666.1;KOX75890.1 Reactome: R-HSA-9610379 HCMV Late Events 32 KOX69061.1;KOX80074.1;KOX72473.1;KOX73226.1;KOX73877.1;KOX79436.1;KOX75539.1;KOX72429.1;KOX77330.1;KOX78305.1;KOX71636.1;KOX68874.1;KOX79242.1;KOX75540.1;KOX74214.1;KOX77058.1;KOX72168.1;KOX74311.1;KOX78183.1;KOX80341.1;KOX68732.1;KOX80793.1;KOX75630.1;KOX81376.1;KOX75811.1;KOX69076.1;KOX73678.1;KOX73131.1;KOX74217.1;KOX73664.1;KOX77505.1;KOX80787.1 Reactome: R-HSA-1538133 G0 and Early G1 5 KOX80899.1;KOX70592.1;KOX73662.1;KOX70054.1;KOX68519.1 KEGG: 00281+4.1.3.4 Geraniol degradation 1 KOX72741.1 MetaCyc: PWY-7721 Methyl phomopsenoate biosynthesis 1 KOX72808.1 Reactome: R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 20 KOX68199.1;KOX77330.1;KOX70913.1;KOX77101.1;KOX73082.1;KOX68054.1;KOX71786.1;KOX71763.1;KOX68243.1;KOX72766.1;KOX79065.1;KOX72221.1;KOX68522.1;KOX71648.1;KOX74217.1;KOX67692.1;KOX80977.1;KOX68851.1;KOX74214.1;KOX74812.1 Reactome: R-HSA-352230 Amino acid transport across the plasma membrane 1 KOX71035.1 MetaCyc: PWY-7574 Propanoyl-coa degradation II 2 KOX71616.1;KOX73119.1 Reactome: R-HSA-196780 Biotin transport and metabolism 6 KOX70011.1;KOX79144.1;KOX68340.1;KOX79449.1;KOX67840.1;KOX79954.1 Reactome: R-HSA-432720 Lysosome Vesicle Biogenesis 6 KOX74577.1;KOX71483.1;KOX68619.1;KOX69308.1;KOX72889.1;KOX76831.1 Reactome: R-HSA-8941326 RUNX2 regulates bone development 1 KOX79878.1 KEGG: 00051+4.2.1.47 Fructose and mannose metabolism 1 KOX69413.1 Reactome: R-HSA-168927 TICAM1, RIP1-mediated IKK complex recruitment 4 KOX67229.1;KOX72105.1;KOX79430.1;KOX79433.1 Reactome: R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 83 KOX79914.1;KOX74170.1;KOX69807.1;KOX81388.1;KOX74407.1;KOX72105.1;KOX77134.1;KOX73982.1;KOX74668.1;KOX72644.1;KOX67280.1;KOX75483.1;KOX71077.1;KOX76065.1;KOX72185.1;KOX75797.1;KOX74357.1;KOX75024.1;KOX81215.1;KOX78350.1;KOX72660.1;KOX68431.1;KOX71988.1;KOX77911.1;KOX74637.1;KOX67361.1;KOX73344.1;KOX79160.1;KOX80864.1;KOX77016.1;KOX71651.1;KOX75227.1;KOX79738.1;KOX79433.1;KOX78568.1;KOX76900.1;KOX70024.1;KOX74908.1;KOX72904.1;KOX67237.1;KOX75432.1;KOX72125.1;KOX74909.1;KOX75945.1;KOX73889.1;KOX77318.1;KOX77319.1;KOX67227.1;KOX78826.1;KOX73120.1;KOX70874.1;KOX75358.1;KOX68744.1;KOX68107.1;KOX78670.1;KOX68042.1;KOX78289.1;KOX74804.1;KOX73450.1;KOX77188.1;KOX70176.1;KOX69831.1;KOX67699.1;KOX75143.1;KOX67229.1;KOX71403.1;KOX67698.1;KOX70147.1;KOX81212.1;KOX67935.1;KOX79069.1;KOX79430.1;KOX79611.1;KOX72330.1;KOX73308.1;KOX72074.1;KOX67807.1;KOX75958.1;KOX70724.1;KOX78800.1;KOX67795.1;KOX71471.1;KOX71394.1 Reactome: R-HSA-5675221 Negative regulation of MAPK pathway 12 KOX75570.1;KOX69536.1;KOX79433.1;KOX68500.1;KOX67229.1;KOX78816.1;KOX72105.1;KOX76312.1;KOX74854.1;KOX79430.1;KOX71037.1;KOX80917.1 Reactome: R-HSA-877312 Regulation of IFNG signaling 1 KOX69445.1 Reactome: R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins 22 KOX78024.1;KOX69300.1;KOX68873.1;KOX68526.1;KOX73332.1;KOX73258.1;KOX80501.1;KOX67209.1;KOX79433.1;KOX69201.1;KOX72105.1;KOX80906.1;KOX79430.1;KOX75952.1;KOX73333.1;KOX75631.1;KOX73587.1;KOX80043.1;KOX70864.1;KOX67229.1;KOX69613.1;KOX72967.1 KEGG: 00250+1.2.1.88 Alanine, aspartate and glutamate metabolism 1 KOX67769.1 Reactome: R-HSA-9656256 Defective OGG1 Substrate Processing 1 KOX70328.1 MetaCyc: PWY-6642 (R)-cysteate degradation 2 KOX79912.1;KOX71428.1 Reactome: R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants 23 KOX69604.1;KOX69665.1;KOX72040.1;KOX74031.1;KOX67229.1;KOX72334.1;KOX77003.1;KOX79430.1;KOX72105.1;KOX74673.1;KOX67619.1;KOX79433.1;KOX69688.1;KOX68228.1;KOX69998.1;KOX70021.1;KOX71242.1;KOX72031.1;KOX79254.1;KOX67158.1;KOX79871.1;KOX72702.1;KOX77051.1 KEGG: 00030+4.1.2.4 Pentose phosphate pathway 1 KOX77910.1 Reactome: R-HSA-5362768 Hh mutants that don't undergo autocatalytic processing are degraded by ERAD 41 KOX72411.1;KOX68314.1;KOX70598.1;KOX79430.1;KOX76879.1;KOX78266.1;KOX67229.1;KOX76416.1;KOX73060.1;KOX76009.1;KOX70009.1;KOX80582.1;KOX72468.1;KOX78268.1;KOX71606.1;KOX74011.1;KOX73209.1;KOX75984.1;KOX74910.1;KOX74924.1;KOX79433.1;KOX79230.1;KOX79601.1;KOX70419.1;KOX70394.1;KOX72105.1;KOX78786.1;KOX68313.1;KOX70383.1;KOX79363.1;KOX77271.1;KOX72982.1;KOX70760.1;KOX75968.1;KOX79626.1;KOX80008.1;KOX78273.1;KOX69414.1;KOX75337.1;KOX68748.1;KOX69333.1 Reactome: R-HSA-418597 G alpha (z) signalling events 10 KOX79275.1;KOX73149.1;KOX78343.1;KOX69402.1;KOX79467.1;KOX77054.1;KOX78138.1;KOX69081.1;KOX79656.1;KOX76508.1 MetaCyc: PWY-7836 Ganglio-series glycosphingolipids biosynthesis 1 KOX74918.1 MetaCyc: PWY-5530 Sorbitol biosynthesis II 1 KOX69067.1 Reactome: R-HSA-196741 Cobalamin (Cbl, vitamin B12) transport and metabolism 4 KOX67948.1;KOX74544.1;KOX71101.1;KOX76209.1 KEGG: 00071+4.2.1.17+1.1.1.35 Fatty acid degradation 2 KOX75101.1;KOX76405.1 KEGG: 00010+6.2.1.1 Glycolysis / Gluconeogenesis 1 KOX74892.1 KEGG: 00220+3.5.1.2 Arginine biosynthesis 1 KOX80357.1 Reactome: R-HSA-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex 6 KOX75998.1;KOX72105.1;KOX79430.1;KOX79433.1;KOX72966.1;KOX67229.1 MetaCyc: PWY-6367 D-myo-inositol-5-phosphate metabolism 5 KOX74728.1;KOX74989.1;KOX78048.1;KOX75330.1;KOX71582.1 Reactome: R-HSA-5602498 MyD88 deficiency (TLR2/4) 1 KOX68497.1 KEGG: 00010+2.7.2.3 Glycolysis / Gluconeogenesis 1 KOX67203.1 KEGG: 00790+1.5.1.3 Folate biosynthesis 1 KOX80540.1 Reactome: R-HSA-5625900 RHO GTPases activate CIT 1 KOX76700.1 MetaCyc: PWY-7736 Stellatic acid biosynthesis 1 KOX72808.1 Reactome: R-HSA-211897 Cytochrome P450 - arranged by substrate type 1 KOX67363.1 Reactome: R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21 39 KOX79430.1;KOX78266.1;KOX76879.1;KOX70598.1;KOX68314.1;KOX72411.1;KOX76009.1;KOX70009.1;KOX67229.1;KOX76416.1;KOX73060.1;KOX71606.1;KOX72468.1;KOX78268.1;KOX80582.1;KOX74924.1;KOX69688.1;KOX79433.1;KOX75984.1;KOX74910.1;KOX73209.1;KOX74011.1;KOX72105.1;KOX79601.1;KOX79230.1;KOX72982.1;KOX79363.1;KOX77271.1;KOX70383.1;KOX78786.1;KOX68313.1;KOX80008.1;KOX79626.1;KOX75968.1;KOX70760.1;KOX68748.1;KOX69333.1;KOX69414.1;KOX78273.1 Reactome: R-HSA-9620244 Long-term potentiation 3 KOX68537.1;KOX68226.1;KOX78706.1 Reactome: R-HSA-5626978 TNFR1-mediated ceramide production 1 KOX76826.1 Reactome: R-HSA-9607240 FLT3 Signaling 1 KOX81204.1 Reactome: R-HSA-71288 Creatine metabolism 3 KOX70640.1;KOX76532.1;KOX79881.1 Reactome: R-HSA-9027284 Erythropoietin activates RAS 1 KOX81204.1 Reactome: R-HSA-171007 p38MAPK events 2 KOX71145.1;KOX73800.1 KEGG: 04070+2.7.8.11 Phosphatidylinositol signaling system 1 KOX76348.1 Reactome: R-HSA-1660499 Synthesis of PIPs at the plasma membrane 10 KOX77152.1;KOX79807.1;KOX69612.1;KOX70804.1;KOX79243.1;KOX78564.1;KOX75731.1;KOX78498.1;KOX76722.1;KOX74178.1 MetaCyc: PWY-7854 Crotonyl-coa/ethylmalonyl-coa/hydroxybutyryl-coa cycle (engineered) 2 KOX71616.1;KOX73119.1 Reactome: R-HSA-9619483 Activation of AMPK downstream of NMDARs 17 KOX75272.1;KOX79174.1;KOX79744.1;KOX72302.1;KOX69879.1;KOX70129.1;KOX72162.1;KOX72895.1;KOX72163.1;KOX69814.1;KOX72161.1;KOX72843.1;KOX72164.1;KOX77793.1;KOX75316.1;KOX68198.1;KOX81246.1 Reactome: R-HSA-418555 G alpha (s) signalling events 9 KOX78138.1;KOX79656.1;KOX69081.1;KOX76508.1;KOX79013.1;KOX69402.1;KOX73149.1;KOX78343.1;KOX79467.1 KEGG: 00240+1.3.5.2 Pyrimidine metabolism 1 KOX72385.1 Reactome: R-HSA-72649 Translation initiation complex formation 52 KOX77134.1;KOX75967.1;KOX67969.1;KOX70175.1;KOX72644.1;KOX74668.1;KOX72470.1;KOX78826.1;KOX68213.1;KOX70202.1;KOX77634.1;KOX73889.1;KOX79914.1;KOX79833.1;KOX75064.1;KOX71988.1;KOX68431.1;KOX74637.1;KOX77911.1;KOX68107.1;KOX70174.1;KOX75024.1;KOX75797.1;KOX75483.1;KOX76065.1;KOX70874.1;KOX71077.1;KOX69171.1;KOX77016.1;KOX79430.1;KOX81212.1;KOX80864.1;KOX75227.1;KOX80902.1;KOX70176.1;KOX67229.1;KOX69831.1;KOX67237.1;KOX72904.1;KOX78800.1;KOX67795.1;KOX71394.1;KOX72125.1;KOX69593.1;KOX80758.1;KOX75958.1;KOX76900.1;KOX67807.1;KOX79433.1;KOX72074.1;KOX67810.1;KOX70024.1 Reactome: R-HSA-3295583 TRP channels 10 KOX76526.1;KOX80705.1;KOX80578.1;KOX72182.1;KOX75314.1;KOX70909.1;KOX75313.1;KOX71097.1;KOX75310.1;KOX68915.1 KEGG: 00564+2.7.7.41 Glycerophospholipid metabolism 2 KOX67877.1;KOX68030.1 MetaCyc: PWY-6823 Molybdenum cofactor biosynthesis 3 KOX81080.1;KOX69728.1;KOX71043.1 KEGG: 00130+2.1.1.163 Ubiquinone and other terpenoid-quinone biosynthesis 1 KOX75964.1 MetaCyc: PWY-7919 Protein N-glycosylation processing phase (plants and animals) 1 KOX72748.1 Reactome: R-HSA-6803207 TP53 Regulates Transcription of Caspase Activators and Caspases 3 KOX68054.1;KOX73754.1;KOX80158.1 Reactome: R-HSA-202040 G-protein activation 7 KOX79656.1;KOX78343.1;KOX69081.1;KOX67335.1;KOX79467.1;KOX76508.1;KOX74177.1 KEGG: 00720+6.2.1.1 Carbon fixation pathways in prokaryotes 1 KOX74892.1 KEGG: 00230+2.7.4.6 Purine metabolism 4 KOX78412.1;KOX71458.1;KOX78158.1;KOX76865.1 KEGG: 00520+5.1.3.2 Amino sugar and nucleotide sugar metabolism 2 KOX72084.1;KOX77926.1 KEGG: 00220+3.5.1.14 Arginine biosynthesis 1 KOX69073.1 Reactome: R-HSA-5632684 Hedgehog 'on' state 43 KOX79626.1;KOX80008.1;KOX72837.1;KOX70760.1;KOX68621.1;KOX75968.1;KOX68748.1;KOX69333.1;KOX80704.1;KOX78273.1;KOX69414.1;KOX79601.1;KOX70419.1;KOX72105.1;KOX79230.1;KOX79363.1;KOX77271.1;KOX72982.1;KOX78786.1;KOX68313.1;KOX70383.1;KOX72468.1;KOX78268.1;KOX71606.1;KOX80582.1;KOX75984.1;KOX74910.1;KOX74924.1;KOX79433.1;KOX74011.1;KOX73209.1;KOX75631.1;KOX79430.1;KOX76879.1;KOX78266.1;KOX72411.1;KOX68314.1;KOX70598.1;KOX76009.1;KOX70009.1;KOX67229.1;KOX76416.1;KOX73060.1 Reactome: R-HSA-8866427 VLDLR internalisation and degradation 4 KOX68797.1;KOX72138.1;KOX76387.1;KOX69299.1 Reactome: R-HSA-9027277 Erythropoietin activates Phospholipase C gamma (PLCG) 1 KOX71582.1 Reactome: R-HSA-390522 Striated Muscle Contraction 5 KOX76719.1;KOX76679.1;KOX69310.1;KOX70943.1;KOX76718.1 MetaCyc: PWY-7560 Methylerythritol phosphate pathway II 2 KOX74855.1;KOX69770.1 KEGG: 00250+2.6.1.1 Alanine, aspartate and glutamate metabolism 2 KOX79912.1;KOX71428.1 Reactome: R-HSA-69091 Polymerase switching 16 KOX77326.1;KOX67310.1;KOX78863.1;KOX73285.1;KOX81161.1;KOX70673.1;KOX79548.1;KOX69330.1;KOX78024.1;KOX74923.1;KOX77356.1;KOX79678.1;KOX81364.1;KOX71969.1;KOX71452.1;KOX78132.1 MetaCyc: PWY-7619 Juniperonate biosynthesis 21 KOX67486.1;KOX78650.1;KOX79701.1;KOX78657.1;KOX78662.1;KOX77795.1;KOX78654.1;KOX67350.1;KOX68696.1;KOX80068.1;KOX78659.1;KOX75202.1;KOX78660.1;KOX78651.1;KOX68278.1;KOX78653.1;KOX74597.1;KOX78236.1;KOX68279.1;KOX73201.1;KOX78713.1 KEGG: 00360+1.14.16.1 Phenylalanine metabolism 1 KOX77562.1 KEGG: 04070+2.7.1.159 Phosphatidylinositol signaling system 1 KOX80873.1 KEGG: 00051+5.3.1.8 Fructose and mannose metabolism 1 KOX74805.1 Reactome: R-HSA-418594 G alpha (i) signalling events 21 KOX69903.1;KOX70895.1;KOX76508.1;KOX71113.1;KOX79656.1;KOX78138.1;KOX68742.1;KOX71542.1;KOX73149.1;KOX78343.1;KOX79736.1;KOX67335.1;KOX69081.1;KOX70896.1;KOX74177.1;KOX68412.1;KOX79467.1;KOX75383.1;KOX69402.1;KOX76463.1;KOX67385.1 Reactome: R-HSA-6793080 rRNA modification in the mitochondrion 1 KOX70204.1 Reactome: R-HSA-71403 Citric acid cycle (TCA cycle) 20 KOX77849.1;KOX76358.1;KOX75086.1;KOX79547.1;KOX71536.1;KOX79891.1;KOX70384.1;KOX79460.1;KOX76727.1;KOX70768.1;KOX79892.1;KOX75664.1;KOX77859.1;KOX79046.1;KOX72987.1;KOX75738.1;KOX69541.1;KOX79955.1;KOX68680.1;KOX71883.1 Reactome: R-HSA-77387 Insulin receptor recycling 13 KOX69852.1;KOX77098.1;KOX72144.1;KOX75459.1;KOX72760.1;KOX75953.1;KOX74155.1;KOX71792.1;KOX79728.1;KOX78327.1;KOX73541.1;KOX76903.1;KOX70575.1 Reactome: R-HSA-1963640 GRB2 events in ERBB2 signaling 1 KOX81204.1 KEGG: 00230+6.3.5.3 Purine metabolism 1 KOX70064.1 Reactome: R-HSA-381042 PERK regulates gene expression 3 KOX79365.1;KOX70175.1;KOX70174.1 MetaCyc: PWY-3661-1 Glycine betaine degradation II (mammalian) 1 KOX69033.1 Reactome: R-HSA-937042 IRAK2 mediated activation of TAK1 complex 5 KOX67229.1;KOX75998.1;KOX72105.1;KOX79433.1;KOX79430.1 KEGG: 00760+6.3.5.1 Nicotinate and nicotinamide metabolism 1 KOX78680.1 MetaCyc: PWY-7391 Isoprene biosynthesis II (engineered) 4 KOX74855.1;KOX69440.1;KOX70405.1;KOX70146.1 KEGG: 00240+3.1.3.5 Pyrimidine metabolism 2 KOX75972.1;KOX75971.1 KEGG: 00230+6.3.4.13 Purine metabolism 1 KOX79954.1 Reactome: R-HSA-111464 SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes 5 KOX78094.1;KOX69910.1;KOX69899.1;KOX73754.1;KOX78217.1 Reactome: R-HSA-111957 Cam-PDE 1 activation 1 KOX72593.1 MetaCyc: PWY-7799 Arg/N-end rule pathway (eukaryotic) 6 KOX79625.1;KOX75083.1;KOX74650.1;KOX79842.1;KOX71937.1;KOX80535.1 KEGG: 00350+1.1.1.1 Tyrosine metabolism 1 KOX67600.1 KEGG: 00750+1.4.3.5 Vitamin B6 metabolism 2 KOX70645.1;KOX80439.1 Reactome: R-HSA-9028731 Activated NTRK2 signals through FRS2 and FRS3 2 KOX81204.1;KOX67928.1 Reactome: R-HSA-156902 Peptide chain elongation 77 KOX68431.1;KOX71988.1;KOX74637.1;KOX77911.1;KOX71077.1;KOX75483.1;KOX72185.1;KOX76065.1;KOX75024.1;KOX74357.1;KOX75797.1;KOX81215.1;KOX72660.1;KOX78350.1;KOX77134.1;KOX72105.1;KOX73982.1;KOX74668.1;KOX72644.1;KOX67280.1;KOX74170.1;KOX79914.1;KOX69807.1;KOX74407.1;KOX81388.1;KOX72904.1;KOX67237.1;KOX75432.1;KOX75945.1;KOX72125.1;KOX79433.1;KOX79738.1;KOX76900.1;KOX78568.1;KOX70024.1;KOX80864.1;KOX77016.1;KOX71651.1;KOX75227.1;KOX67361.1;KOX73344.1;KOX79160.1;KOX68042.1;KOX74804.1;KOX78289.1;KOX73450.1;KOX75358.1;KOX70874.1;KOX68107.1;KOX68744.1;KOX78670.1;KOX67227.1;KOX73120.1;KOX78826.1;KOX73889.1;KOX71471.1;KOX78800.1;KOX70724.1;KOX67795.1;KOX71394.1;KOX72074.1;KOX73308.1;KOX75958.1;KOX67807.1;KOX67935.1;KOX81212.1;KOX79430.1;KOX67698.1;KOX70147.1;KOX72330.1;KOX79611.1;KOX77188.1;KOX70176.1;KOX67699.1;KOX67229.1;KOX71403.1;KOX75143.1 MetaCyc: PWY-6834 Spermidine biosynthesis III 2 KOX68063.1;KOX68062.1 MetaCyc: PWY-7049 Icosapentaenoate biosynthesis II (6-desaturase, mammals) 2 KOX79701.1;KOX78236.1 MetaCyc: PWY-7606 Docosahexaenoate biosynthesis III (6-desaturase, mammals) 6 KOX76405.1;KOX71616.1;KOX78236.1;KOX75101.1;KOX79701.1;KOX73119.1 MetaCyc: PWY-2781 Cis-zeatin biosynthesis 2 KOX76647.1;KOX76640.1 Reactome: R-HSA-2029485 Role of phospholipids in phagocytosis 4 KOX73812.1;KOX80284.1;KOX71582.1;KOX74104.1 MetaCyc: PWY-6859 All-trans-farnesol biosynthesis 2 KOX72808.1;KOX74855.1 Reactome: R-HSA-6794361 Neurexins and neuroligins 12 KOX76197.1;KOX73876.1;KOX80414.1;KOX78201.1;KOX75367.1;KOX76789.1;KOX80552.1;KOX68338.1;KOX74772.1;KOX76332.1;KOX68537.1;KOX75507.1 Reactome: R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 39 KOX71506.1;KOX73785.1;KOX70744.1;KOX79649.1;KOX77062.1;KOX74030.1;KOX79742.1;KOX78553.1;KOX76250.1;KOX67200.1;KOX72082.1;KOX71763.1;KOX77418.1;KOX68054.1;KOX69424.1;KOX69719.1;KOX74919.1;KOX80229.1;KOX67799.1;KOX81203.1;KOX75987.1;KOX72538.1;KOX73517.1;KOX69897.1;KOX79522.1;KOX81403.1;KOX80159.1;KOX74806.1;KOX70044.1;KOX69540.1;KOX77626.1;KOX81395.1;KOX74945.1;KOX70730.1;KOX68573.1;KOX77063.1;KOX67622.1;KOX73198.1;KOX78696.1 Reactome: R-HSA-8949613 Cristae formation 19 KOX68460.1;KOX72898.1;KOX79945.1;KOX77486.1;KOX78342.1;KOX78865.1;KOX75607.1;KOX78160.1;KOX75213.1;KOX74466.1;KOX67478.1;KOX73329.1;KOX79538.1;KOX74025.1;KOX77829.1;KOX70867.1;KOX67479.1;KOX80220.1;KOX79165.1 KEGG: 00230+2.7.4.8 Purine metabolism 6 KOX72712.1;KOX70499.1;KOX78444.1;KOX73158.1;KOX78842.1;KOX72404.1 MetaCyc: PWY-7778 2-methylpropene degradation 2 KOX75101.1;KOX76405.1 Reactome: R-HSA-77595 Processing of Intronless Pre-mRNAs 11 KOX77867.1;KOX75893.1;KOX74909.1;KOX71803.1;KOX67153.1;KOX67341.1;KOX81159.1;KOX69435.1;KOX74908.1;KOX75678.1;KOX79349.1 KEGG: 00860+1.16.3.1 Porphyrin and chlorophyll metabolism 1 KOX74978.1 KEGG: 00280+1.8.1.4 Valine, leucine and isoleucine degradation 1 KOX75086.1 KEGG: 00330+1.14.11.2 Arginine and proline metabolism 2 KOX71490.1;KOX71492.1 MetaCyc: PWY-7546 Diphthamide biosynthesis II (eukaryotes) 3 KOX81155.1;KOX77844.1;KOX77355.1 Reactome: R-HSA-5362798 Release of Hh-Np from the secreting cell 2 KOX80704.1;KOX67619.1 Reactome: R-HSA-75153 Apoptotic execution phase 1 KOX74157.1 Reactome: R-HSA-5689877 Josephin domain DUBs 8 KOX81152.1;KOX67229.1;KOX81224.1;KOX79433.1;KOX75938.1;KOX78340.1;KOX72105.1;KOX79430.1 Reactome: R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex 17 KOX75547.1;KOX74812.1;KOX74214.1;KOX74217.1;KOX76731.1;KOX79675.1;KOX73641.1;KOX75631.1;KOX69059.1;KOX69586.1;KOX80906.1;KOX75454.1;KOX77330.1;KOX69665.1;KOX67626.1;KOX72153.1;KOX72851.1 Reactome: R-HSA-193648 NRAGE signals death through JNK 13 KOX74663.1;KOX73980.1;KOX74133.1;KOX80890.1;KOX71583.1;KOX78997.1;KOX78917.1;KOX71644.1;KOX79097.1;KOX71191.1;KOX81333.1;KOX69925.1;KOX68654.1 MetaCyc: PWY-5912 2'-deoxymugineic acid phytosiderophore biosynthesis 1 KOX77579.1 MetaCyc: PWY-7111 Pyruvate fermentation to isobutanol (engineered) 1 KOX67600.1 MetaCyc: PWY-7216 (R)- and (S)-3-hydroxybutanoate biosynthesis (engineered) 2 KOX76405.1;KOX75101.1 Reactome: R-HSA-175474 Assembly Of The HIV Virion 4 KOX79430.1;KOX79433.1;KOX72105.1;KOX67229.1 Reactome: R-HSA-9027276 Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 1 KOX79243.1 Reactome: R-HSA-3785653 Myoclonic epilepsy of Lafora 4 KOX79433.1;KOX79430.1;KOX72105.1;KOX67229.1 KEGG: 00270+4.4.1.13 Cysteine and methionine metabolism 1 KOX80071.1 Reactome: R-HSA-433137 Sodium-coupled sulphate, di- and tri-carboxylate transporters 2 KOX74545.1;KOX74553.1 Reactome: R-HSA-6802948 Signaling by high-kinase activity BRAF mutants 3 KOX68500.1;KOX68521.1;KOX79918.1 MetaCyc: PWY-7013 (S)-propane-1,2-diol degradation 1 KOX67600.1 MetaCyc: PWY-5890 Menaquinol-10 biosynthesis 1 KOX75964.1 Reactome: R-HSA-112409 RAF-independent MAPK1/3 activation 3 KOX78816.1;KOX68500.1;KOX75570.1 Reactome: R-HSA-70895 Branched-chain amino acid catabolism 6 KOX67897.1;KOX74518.1;KOX81134.1;KOX72274.1;KOX75285.1;KOX75086.1 MetaCyc: PWY-7344 UDP-alpha-D-galactose biosynthesis 2 KOX77926.1;KOX72084.1 Reactome: R-HSA-420029 Tight junction interactions 4 KOX69840.1;KOX72404.1;KOX69841.1;KOX72455.1 MetaCyc: PWY-5189 Tetrapyrrole biosynthesis II (from glycine) 4 KOX79366.1;KOX73781.1;KOX78820.1;KOX74171.1 KEGG: 00232+1.17.3.2 Caffeine metabolism 1 KOX71781.1 Reactome: R-HSA-9645135 STAT5 Activation 1 KOX81204.1 KEGG: 00790+3.5.4.16 Folate biosynthesis 1 KOX73788.1 Reactome: R-HSA-159740 Gamma-carboxylation of protein precursors 1 KOX69948.1 Reactome: R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation 30 KOX79649.1;KOX81200.1;KOX75217.1;KOX80740.1;KOX77100.1;KOX74869.1;KOX67394.1;KOX77884.1;KOX68921.1;KOX76947.1;KOX71970.1;KOX77836.1;KOX81254.1;KOX74451.1;KOX67791.1;KOX68645.1;KOX77062.1;KOX77413.1;KOX70382.1;KOX79353.1;KOX67688.1;KOX79544.1;KOX77626.1;KOX81203.1;KOX73198.1;KOX72899.1;KOX72891.1;KOX74448.1;KOX78581.1;KOX77063.1 Reactome: R-HSA-5649702 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway 2 KOX79322.1;KOX70328.1 KEGG: 00970+6.1.1.4 Aminoacyl-tRNA biosynthesis 1 KOX74356.1 KEGG: 00100+1.3.1.70 Steroid biosynthesis 1 KOX78838.1 KEGG: 00720+4.2.1.2 Carbon fixation pathways in prokaryotes 1 KOX77859.1 Reactome: R-HSA-73930 Abasic sugar-phosphate removal via the single-nucleotide replacement pathway 1 KOX77974.1 Reactome: R-HSA-429958 mRNA decay by 3' to 5' exoribonuclease 14 KOX71950.1;KOX77417.1;KOX77059.1;KOX71022.1;KOX79938.1;KOX68469.1;KOX76988.1;KOX69500.1;KOX67373.1;KOX70791.1;KOX71869.1;KOX68192.1;KOX79092.1;KOX68794.1 KEGG: 05163+2.7.11.1 Human cytomegalovirus infection 40 KOX79039.1;KOX68566.1;KOX77803.1;KOX70561.1;KOX68521.1;KOX74479.1;KOX79033.1;KOX77506.1;KOX73800.1;KOX68654.1;KOX68084.1;KOX79166.1;KOX73362.1;KOX71595.1;KOX79522.1;KOX78362.1;KOX73724.1;KOX79817.1;KOX69619.1;KOX71579.1;KOX68054.1;KOX70861.1;KOX74186.1;KOX72201.1;KOX77898.1;KOX79675.1;KOX78509.1;KOX74477.1;KOX68647.1;KOX76214.1;KOX81246.1;KOX77364.1;KOX78841.1;KOX72400.1;KOX73463.1;KOX69995.1;KOX79225.1;KOX76221.1;KOX70676.1;KOX79935.1 Reactome: R-HSA-68877 Mitotic Prometaphase 46 KOX73340.1;KOX74302.1;KOX74202.1;KOX75516.1;KOX70729.1;KOX72895.1;KOX77505.1;KOX80503.1;KOX75211.1;KOX69536.1;KOX78000.1;KOX72843.1;KOX68198.1;KOX72021.1;KOX68732.1;KOX69417.1;KOX81286.1;KOX76379.1;KOX72068.1;KOX80793.1;KOX75601.1;KOX68210.1;KOX76545.1;KOX72302.1;KOX79744.1;KOX81328.1;KOX79174.1;KOX79242.1;KOX71037.1;KOX75272.1;KOX71089.1;KOX69879.1;KOX72162.1;KOX70129.1;KOX77058.1;KOX78195.1;KOX78693.1;KOX72164.1;KOX77793.1;KOX79039.1;KOX69061.1;KOX72161.1;KOX72163.1;KOX72473.1;KOX68498.1;KOX76312.1 MetaCyc: PWY-7822 Chitin degradation III (Serratia) 10 KOX79324.1;KOX75966.1;KOX74395.1;KOX74285.1;KOX74631.1;KOX73530.1;KOX77106.1;KOX72270.1;KOX79466.1;KOX79627.1 Reactome: R-HSA-75109 Triglyceride biosynthesis 4 KOX71603.1;KOX72546.1;KOX74206.1;KOX67863.1 Reactome: R-HSA-180910 Vpr-mediated nuclear import of PICs 20 KOX69061.1;KOX72473.1;KOX78183.1;KOX68732.1;KOX73226.1;KOX80341.1;KOX80793.1;KOX79436.1;KOX75630.1;KOX75539.1;KOX72429.1;KOX81376.1;KOX68874.1;KOX75811.1;KOX79242.1;KOX75540.1;KOX77058.1;KOX73131.1;KOX73664.1;KOX77505.1 Reactome: R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA 21 KOX67394.1;KOX79649.1;KOX81200.1;KOX77884.1;KOX67791.1;KOX74451.1;KOX68921.1;KOX76947.1;KOX71970.1;KOX68645.1;KOX77062.1;KOX77413.1;KOX73082.1;KOX70382.1;KOX77626.1;KOX68243.1;KOX72766.1;KOX73198.1;KOX81203.1;KOX77063.1;KOX72899.1 KEGG: 00071+5.1.2.3+4.2.1.17+1.1.1.35 Fatty acid degradation 2 KOX75101.1;KOX76405.1 MetaCyc: PWY-5695 Inosine 5'-phosphate degradation 5 KOX78850.1;KOX78203.1;KOX75971.1;KOX75972.1;KOX71781.1 Reactome: R-HSA-3371453 Regulation of HSF1-mediated heat shock response 38 KOX75811.1;KOX81376.1;KOX74550.1;KOX73871.1;KOX73131.1;KOX77505.1;KOX73664.1;KOX68500.1;KOX75410.1;KOX78218.1;KOX68054.1;KOX73554.1;KOX78183.1;KOX80341.1;KOX79365.1;KOX76184.1;KOX68732.1;KOX80793.1;KOX75630.1;KOX77678.1;KOX68874.1;KOX80230.1;KOX81288.1;KOX79242.1;KOX75540.1;KOX77058.1;KOX79522.1;KOX76183.1;KOX69061.1;KOX78349.1;KOX72473.1;KOX73226.1;KOX70402.1;KOX79436.1;KOX72417.1;KOX75539.1;KOX69775.1;KOX72429.1 Reactome: R-HSA-2129379 Molecules associated with elastic fibres 3 KOX81084.1;KOX70786.1;KOX70849.1 Reactome: R-HSA-2408522 Selenoamino acid metabolism 8 KOX67618.1;KOX71397.1;KOX71409.1;KOX76511.1;KOX71972.1;KOX78851.1;KOX79545.1;KOX75798.1 Reactome: R-HSA-9635644 Inhibition of membrane repair 1 KOX71483.1 MetaCyc: PWYG-321 2 KOX69550.1;KOX73549.1 Reactome: R-HSA-156842 Eukaryotic Translation Elongation 5 KOX75059.1;KOX74266.1;KOX78929.1;KOX67704.1;KOX72467.1 Reactome: R-HSA-110320 Translesion Synthesis by POLH 19 KOX73285.1;KOX72802.1;KOX67229.1;KOX70673.1;KOX72417.1;KOX79430.1;KOX72105.1;KOX67310.1;KOX67472.1;KOX70402.1;KOX79433.1;KOX72804.1;KOX71427.1;KOX71452.1;KOX71969.1;KOX79548.1;KOX77378.1;KOX78024.1;KOX74923.1 KEGG: 00680+3.1.3.11 Methane metabolism 1 KOX68814.1 Reactome: R-HSA-8941332 RUNX2 regulates genes involved in cell migration 2 KOX72400.1;KOX79878.1 Reactome: R-HSA-933542 TRAF6 mediated NF-kB activation 1 KOX72966.1 Reactome: R-HSA-9029558 NR1H2 & NR1H3 regulate gene expression linked to lipogenesis 2 KOX69550.1;KOX73549.1 Reactome: R-HSA-75955 RNA Polymerase II Transcription Elongation 40 KOX77062.1;KOX74916.1;KOX79649.1;KOX71506.1;KOX73785.1;KOX79279.1;KOX81203.1;KOX67799.1;KOX72967.1;KOX69719.1;KOX73587.1;KOX74919.1;KOX69424.1;KOX80906.1;KOX77418.1;KOX72082.1;KOX75631.1;KOX67200.1;KOX78553.1;KOX74030.1;KOX74806.1;KOX80159.1;KOX81403.1;KOX69309.1;KOX73186.1;KOX69897.1;KOX72538.1;KOX75987.1;KOX78696.1;KOX73198.1;KOX67622.1;KOX68573.1;KOX70730.1;KOX70864.1;KOX77063.1;KOX74945.1;KOX81395.1;KOX77626.1;KOX69540.1;KOX70044.1 Reactome: R-HSA-73780 RNA Polymerase III Chain Elongation 18 KOX73198.1;KOX81203.1;KOX77063.1;KOX72899.1;KOX70382.1;KOX77626.1;KOX74451.1;KOX67791.1;KOX76947.1;KOX68921.1;KOX71970.1;KOX68645.1;KOX77413.1;KOX77062.1;KOX67394.1;KOX79649.1;KOX81200.1;KOX77884.1 KEGG: 00520+5.4.2.10 Amino sugar and nucleotide sugar metabolism 3 KOX74440.1;KOX79915.1;KOX70795.1 KEGG: 00020+6.2.1.5 Citrate cycle (TCA cycle) 4 KOX79460.1;KOX79892.1;KOX79891.1;KOX74316.1 MetaCyc: PWY-6731 Starch degradation III 1 KOX80377.1 KEGG: 00740+3.6.1.9 Riboflavin metabolism 2 KOX69334.1;KOX80826.1 KEGG: 04070+3.1.3.56 Phosphatidylinositol signaling system 1 KOX69866.1 KEGG: 00908+2.5.1.75 Zeatin biosynthesis 2 KOX76647.1;KOX76640.1 KEGG: 00630+2.1.2.1 Glyoxylate and dicarboxylate metabolism 1 KOX69033.1 Reactome: R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 41 KOX78158.1;KOX79428.1;KOX76312.1;KOX72163.1;KOX72161.1;KOX77793.1;KOX72164.1;KOX71404.1;KOX68021.1;KOX70798.1;KOX72162.1;KOX70129.1;KOX69879.1;KOX79985.1;KOX74238.1;KOX75272.1;KOX79174.1;KOX80122.1;KOX79744.1;KOX72302.1;KOX77754.1;KOX68936.1;KOX73600.1;KOX69877.1;KOX68198.1;KOX71516.1;KOX78129.1;KOX75429.1;KOX72843.1;KOX72931.1;KOX76822.1;KOX72895.1;KOX79233.1;KOX75699.1;KOX75516.1;KOX71287.1;KOX73591.1;KOX79004.1;KOX78488.1;KOX69780.1;KOX75559.1 Reactome: R-HSA-4719360 Defective DPM3 causes DPM3-CDG (CDG-1o) 3 KOX72243.1;KOX73553.1;KOX78339.1 Reactome: R-HSA-5678895 Defective CFTR causes cystic fibrosis 43 KOX74011.1;KOX72942.1;KOX73209.1;KOX74910.1;KOX75984.1;KOX79433.1;KOX74924.1;KOX80582.1;KOX78268.1;KOX72468.1;KOX71606.1;KOX73060.1;KOX76416.1;KOX67229.1;KOX70009.1;KOX76009.1;KOX72411.1;KOX68314.1;KOX70598.1;KOX76879.1;KOX78266.1;KOX79430.1;KOX78273.1;KOX69414.1;KOX69333.1;KOX68043.1;KOX75337.1;KOX68748.1;KOX70760.1;KOX75968.1;KOX79626.1;KOX80008.1;KOX68313.1;KOX78786.1;KOX70383.1;KOX79363.1;KOX77271.1;KOX72982.1;KOX79230.1;KOX79601.1;KOX72913.1;KOX72105.1;KOX70419.1 KEGG: 00860+2.5.1.17 Porphyrin and chlorophyll metabolism 1 KOX67948.1 KEGG: 00561+3.1.1.3 Glycerolipid metabolism 1 KOX67326.1 Reactome: R-HSA-5635838 Activation of SMO 4 KOX68621.1;KOX67570.1;KOX80704.1;KOX75983.1 Reactome: R-HSA-163615 PKA activation 5 KOX74139.1;KOX69402.1;KOX73149.1;KOX78138.1;KOX71184.1 Reactome: R-HSA-9013695 NOTCH4 Intracellular Domain Regulates Transcription 4 KOX69665.1;KOX67158.1;KOX69604.1;KOX71242.1 KEGG: 00980+1.1.1.1 Metabolism of xenobiotics by cytochrome P450 1 KOX67600.1 MetaCyc: PWY-6369 Inositol diphosphates biosynthesis 4 KOX81238.1;KOX81095.1;KOX81239.1;KOX81098.1 KEGG: 00770+2.7.8.7 Pantothenate and CoA biosynthesis 1 KOX75794.1 KEGG: 00480+1.1.1.49 Glutathione metabolism 1 KOX73807.1 KEGG: 00510+2.4.1.260 N-Glycan biosynthesis 1 KOX77289.1 Reactome: R-HSA-5576886 Phase 4 - resting membrane potential 9 KOX80623.1;KOX75883.1;KOX71128.1;KOX72086.1;KOX77421.1;KOX69800.1;KOX71130.1;KOX78676.1;KOX73074.1 KEGG: 00520+1.1.1.22 Amino sugar and nucleotide sugar metabolism 1 KOX69806.1 MetaCyc: PWY-6891 Thiazole biosynthesis II (aerobic bacteria) 1 KOX69770.1 MetaCyc: PWY-6583 Pyruvate fermentation to butanol I 2 KOX75101.1;KOX76405.1 Reactome: R-HSA-8957275 Post-translational protein phosphorylation 11 KOX69868.1;KOX78325.1;KOX73976.1;KOX80996.1;KOX73997.1;KOX72153.1;KOX69658.1;KOX68929.1;KOX68248.1;KOX69335.1;KOX71944.1 Reactome: R-HSA-1251985 Nuclear signaling by ERBB4 5 KOX69998.1;KOX70021.1;KOX68228.1;KOX67619.1;KOX77051.1 KEGG: 00250+6.3.4.4 Alanine, aspartate and glutamate metabolism 1 KOX81300.1 Reactome: R-HSA-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 2 KOX69543.1;KOX67865.1 KEGG: 00564+3.1.1.4+3.1.1.5 Glycerophospholipid metabolism 3 KOX78275.1;KOX78399.1;KOX78316.1 Reactome: R-HSA-112311 Neurotransmitter clearance 3 KOX79335.1;KOX80407.1;KOX70692.1 KEGG: 00514+2.4.1.109 Other types of O-glycan biosynthesis 5 KOX81252.1;KOX77837.1;KOX70674.1;KOX71057.1;KOX72250.1 KEGG: 00982+2.5.1.18 Drug metabolism - cytochrome P450 3 KOX69433.1;KOX71878.1;KOX71611.1 MetaCyc: PWY-7158 L-phenylalanine degradation V 2 KOX75737.1;KOX77562.1 Reactome: R-HSA-5676934 Protein repair 2 KOX68083.1;KOX80913.1 Reactome: R-HSA-5467348 Truncations of AMER1 destabilize the destruction complex 5 KOX76312.1;KOX73320.1;KOX71037.1;KOX75788.1;KOX69536.1 Reactome: R-HSA-196836 Vitamin C (ascorbate) metabolism 2 KOX71878.1;KOX69433.1 KEGG: 00620+6.2.1.1 Pyruvate metabolism 1 KOX74892.1 Reactome: R-HSA-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 10 KOX71269.1;KOX77790.1;KOX71738.1;KOX77289.1;KOX74948.1;KOX76984.1;KOX74903.1;KOX73088.1;KOX72002.1;KOX72671.1 KEGG: 00550+2.7.8.13 Peptidoglycan biosynthesis 1 KOX77790.1 Reactome: R-HSA-209905 Catecholamine biosynthesis 1 KOX71846.1 Reactome: R-HSA-200425 Carnitine metabolism 3 KOX70011.1;KOX69814.1;KOX81293.1 Reactome: R-HSA-5656169 Termination of translesion DNA synthesis 22 KOX77276.1;KOX70402.1;KOX77326.1;KOX67310.1;KOX79430.1;KOX72105.1;KOX67229.1;KOX70673.1;KOX72417.1;KOX73285.1;KOX80464.1;KOX78024.1;KOX74923.1;KOX79548.1;KOX77830.1;KOX71969.1;KOX73720.1;KOX71452.1;KOX75918.1;KOX79433.1;KOX77356.1;KOX81364.1 Reactome: R-HSA-177504 Retrograde neurotrophin signalling 3 KOX69299.1;KOX68797.1;KOX76387.1 KEGG: 00480+3.4.11.1 Glutathione metabolism 2 KOX80189.1;KOX72754.1 Reactome: R-HSA-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 6 KOX80039.1;KOX67229.1;KOX75998.1;KOX72105.1;KOX79430.1;KOX79433.1 Reactome: R-HSA-2151209 Activation of PPARGC1A (PGC-1alpha) by phosphorylation 2 KOX69814.1;KOX75316.1 KEGG: 00020+1.1.1.42 Citrate cycle (TCA cycle) 1 KOX79046.1 Reactome: R-HSA-9609523 Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 7 KOX68060.1;KOX71146.1;KOX68636.1;KOX69034.1;KOX77820.1;KOX70253.1;KOX70579.1 Reactome: R-HSA-8963693 Aspartate and asparagine metabolism 2 KOX69818.1;KOX71052.1 KEGG: 00480+1.11.1.15 Glutathione metabolism 8 KOX80161.1;KOX69212.1;KOX72875.1;KOX75462.1;KOX74953.1;KOX80160.1;KOX75562.1;KOX73557.1 Reactome: R-HSA-4570464 SUMOylation of RNA binding proteins 21 KOX72473.1;KOX74311.1;KOX69061.1;KOX68732.1;KOX73226.1;KOX80341.1;KOX78183.1;KOX75630.1;KOX80793.1;KOX79436.1;KOX72429.1;KOX75539.1;KOX79242.1;KOX68874.1;KOX81376.1;KOX75811.1;KOX75540.1;KOX73131.1;KOX77058.1;KOX77505.1;KOX73664.1 MetaCyc: PWY-7831 ABH and Lewis epitopes biosynthesis from type 2 precursor disaccharide 1 KOX67571.1 KEGG: 00983+2.7.4.14 Drug metabolism - other enzymes 1 KOX77775.1 Reactome: R-HSA-163359 Glucagon signaling in metabolic regulation 7 KOX73149.1;KOX78138.1;KOX79656.1;KOX69402.1;KOX78343.1;KOX69081.1;KOX79467.1 Reactome: R-HSA-1482788 Acyl chain remodelling of PC 8 KOX75783.1;KOX69576.1;KOX78275.1;KOX72448.1;KOX78399.1;KOX69497.1;KOX79218.1;KOX78316.1 Reactome: R-HSA-418359 Reduction of cytosolic Ca++ levels 4 KOX71030.1;KOX72009.1;KOX76050.1;KOX71026.1 KEGG: 04660+3.1.3.16 T cell receptor signaling pathway 30 KOX72941.1;KOX71414.1;KOX69703.1;KOX72757.1;KOX74854.1;KOX68760.1;KOX68258.1;KOX74165.1;KOX68259.1;KOX78476.1;KOX71725.1;KOX76691.1;KOX75891.1;KOX70730.1;KOX68255.1;KOX78816.1;KOX80916.1;KOX69134.1;KOX79996.1;KOX73439.1;KOX71507.1;KOX78718.1;KOX75570.1;KOX74437.1;KOX74359.1;KOX71123.1;KOX73821.1;KOX81157.1;KOX72905.1;KOX67474.1 Reactome: R-HSA-5576893 Phase 2 - plateau phase 5 KOX69774.1;KOX69225.1;KOX79241.1;KOX70316.1;KOX70317.1 MetaCyc: PWY-8061 8-oxo-(d)GTP detoxification II 1 KOX73945.1 Reactome: R-HSA-6804759 Regulation of TP53 Activity through Association with Co-factors 3 KOX80158.1;KOX78699.1;KOX72400.1 KEGG: 00900+2.3.3.10 Terpenoid backbone biosynthesis 1 KOX70405.1 MetaCyc: PWY-6282 Palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate) 2 KOX69550.1;KOX73549.1 Reactome: R-HSA-9645460 Alpha-protein kinase 1 signaling pathway 5 KOX67229.1;KOX75998.1;KOX72105.1;KOX79433.1;KOX79430.1 Reactome: R-HSA-1169091 Activation of NF-kappaB in B cells 42 KOX73060.1;KOX67229.1;KOX76416.1;KOX70009.1;KOX76009.1;KOX70598.1;KOX68314.1;KOX72411.1;KOX76879.1;KOX78266.1;KOX79430.1;KOX73209.1;KOX74011.1;KOX79433.1;KOX69688.1;KOX74924.1;KOX74910.1;KOX75984.1;KOX80582.1;KOX71606.1;KOX78268.1;KOX72468.1;KOX70383.1;KOX68313.1;KOX78786.1;KOX80285.1;KOX72982.1;KOX77271.1;KOX79363.1;KOX79230.1;KOX72105.1;KOX70419.1;KOX79601.1;KOX69414.1;KOX78273.1;KOX69333.1;KOX68748.1;KOX75968.1;KOX70760.1;KOX75998.1;KOX80008.1;KOX79626.1 Reactome: R-HSA-111469 SMAC, XIAP-regulated apoptotic response 1 KOX78217.1 Reactome: R-HSA-191859 snRNP Assembly 36 KOX75630.1;KOX69502.1;KOX72122.1;KOX75619.1;KOX80793.1;KOX80374.1;KOX75618.1;KOX80341.1;KOX78052.1;KOX67590.1;KOX68732.1;KOX78183.1;KOX78050.1;KOX73131.1;KOX73664.1;KOX77505.1;KOX74908.1;KOX81376.1;KOX75811.1;KOX74043.1;KOX74909.1;KOX73321.1;KOX70728.1;KOX79436.1;KOX78065.1;KOX72429.1;KOX75539.1;KOX72473.1;KOX69061.1;KOX73226.1;KOX77058.1;KOX79242.1;KOX68874.1;KOX75540.1;KOX69369.1;KOX72487.1 MetaCyc: PWY-4061 Glutathione-mediated detoxification I 6 KOX69433.1;KOX79924.1;KOX71878.1;KOX78785.1;KOX71346.1;KOX71611.1 MetaCyc: PWY-6537 4-aminobutanoate degradation II 1 KOX75380.1 KEGG: 00562+3.1.3.66 Inositol phosphate metabolism 1 KOX78498.1 Reactome: R-HSA-5083628 Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 1 KOX80772.1 MetaCyc: PWY-7233 Ubiquinol-6 bypass biosynthesis (eukaryotic) 2 KOX70323.1;KOX72023.1 Reactome: R-HSA-5675482 Regulation of necroptotic cell death 4 KOX67229.1;KOX72105.1;KOX79433.1;KOX79430.1 Reactome: R-HSA-264642 Acetylcholine Neurotransmitter Release Cycle 2 KOX74367.1;KOX74364.1 KEGG: 00250+2.4.2.14 Alanine, aspartate and glutamate metabolism 1 KOX67689.1 Reactome: R-HSA-9022699 MECP2 regulates neuronal receptors and channels 1 KOX71680.1 MetaCyc: PWY-7918 Protein N-glycosylation processing phase (yeast) 1 KOX72748.1 MetaCyc: PWY-7494 Choline degradation IV 4 KOX71151.1;KOX67667.1;KOX78880.1;KOX69462.1 MetaCyc: PWY-6129 Dolichol and dolichyl phosphate biosynthesis 2 KOX67918.1;KOX80579.1 Reactome: R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 21 KOX75539.1;KOX72429.1;KOX79436.1;KOX80793.1;KOX75630.1;KOX78183.1;KOX68732.1;KOX73226.1;KOX80341.1;KOX69061.1;KOX72473.1;KOX77505.1;KOX73664.1;KOX77058.1;KOX73131.1;KOX75540.1;KOX68874.1;KOX75811.1;KOX81376.1;KOX79264.1;KOX79242.1 MetaCyc: PWY-7198 Pyrimidine deoxyribonucleotides de novo biosynthesis IV 8 KOX74853.1;KOX76865.1;KOX78158.1;KOX79885.1;KOX71982.1;KOX78412.1;KOX71458.1;KOX79122.1 Reactome: R-HSA-163125 Post-translational modification: synthesis of GPI-anchored proteins 1 KOX79399.1 KEGG: 00260+1.2.1.8+1.1.99.1 Glycine, serine and threonine metabolism 4 KOX78880.1;KOX69462.1;KOX71151.1;KOX67667.1 MetaCyc: PWY-7382 Lipoate biosynthesis and incorporation IV (yeast) 4 KOX75142.1;KOX75475.1;KOX71375.1;KOX79449.1 MetaCyc: PWY-7445 Luteolin triglucuronide degradation 2 KOX69438.1;KOX77231.1 Reactome: R-HSA-1614558 Degradation of cysteine and homocysteine 3 KOX69981.1;KOX76293.1;KOX69327.1 MetaCyc: PWY-7124 Ethylene biosynthesis V (engineered) 3 KOX81104.1;KOX71859.1;KOX79046.1 Reactome: R-HSA-72689 Formation of a pool of free 40S subunits 89 KOX79433.1;KOX79738.1;KOX76900.1;KOX78568.1;KOX70024.1;KOX72904.1;KOX67237.1;KOX75432.1;KOX69593.1;KOX80758.1;KOX75945.1;KOX72125.1;KOX67361.1;KOX73344.1;KOX79160.1;KOX80864.1;KOX77016.1;KOX71651.1;KOX75227.1;KOX76065.1;KOX75483.1;KOX71077.1;KOX72185.1;KOX75024.1;KOX74357.1;KOX75797.1;KOX81215.1;KOX72660.1;KOX78350.1;KOX68431.1;KOX71988.1;KOX75064.1;KOX77911.1;KOX74637.1;KOX74170.1;KOX79914.1;KOX77634.1;KOX70202.1;KOX69807.1;KOX74407.1;KOX81388.1;KOX79833.1;KOX77134.1;KOX72105.1;KOX73982.1;KOX72644.1;KOX72470.1;KOX74668.1;KOX67280.1;KOX72074.1;KOX73308.1;KOX75958.1;KOX67807.1;KOX67810.1;KOX71471.1;KOX67795.1;KOX78800.1;KOX70724.1;KOX71394.1;KOX77188.1;KOX70176.1;KOX67699.1;KOX71403.1;KOX67229.1;KOX75143.1;KOX67935.1;KOX79430.1;KOX81212.1;KOX70147.1;KOX67698.1;KOX69171.1;KOX80902.1;KOX72330.1;KOX79611.1;KOX75358.1;KOX70874.1;KOX68107.1;KOX68744.1;KOX78670.1;KOX68042.1;KOX74804.1;KOX78289.1;KOX73450.1;KOX73889.1;KOX75967.1;KOX67227.1;KOX67969.1;KOX73120.1;KOX78826.1 Reactome: R-HSA-5674499 Negative feedback regulation of MAPK pathway 1 KOX68500.1 Reactome: R-HSA-400253 Circadian Clock 16 KOX79433.1;KOX69688.1;KOX70968.1;KOX74904.1;KOX68963.1;KOX69665.1;KOX71725.1;KOX67229.1;KOX76309.1;KOX78228.1;KOX72105.1;KOX79430.1;KOX69703.1;KOX70971.1;KOX78052.1;KOX67887.1 MetaCyc: PWY-5856 Ubiquinol-9 biosynthesis (prokaryotic) 3 KOX70323.1;KOX72023.1;KOX77776.1 KEGG: 00680+6.2.1.1 Methane metabolism 1 KOX74892.1 Reactome: R-HSA-390450 Folding of actin by CCT/TriC 8 KOX78324.1;KOX76507.1;KOX67167.1;KOX69602.1;KOX76721.1;KOX81218.1;KOX76688.1;KOX69322.1 KEGG: 00660+6.2.1.5 C5-Branched dibasic acid metabolism 4 KOX74316.1;KOX79460.1;KOX79892.1;KOX79891.1 Reactome: R-HSA-8866907 Activation of the TFAP2 (AP-2) family of transcription factors 2 KOX73958.1;KOX69665.1 MetaCyc: PWY-6435 4-hydroxybenzoate biosynthesis III (plants) 2 KOX75101.1;KOX76405.1 MetaCyc: PWY-5030 L-histidine degradation III 2 KOX77269.1;KOX67514.1 Reactome: R-HSA-3560783 Defective B4GALT7 causes EDS, progeroid type 4 KOX73118.1;KOX76492.1;KOX80364.1;KOX80363.1 Reactome: R-HSA-5358749 S37 mutants of beta-catenin aren't phosphorylated 5 KOX69536.1;KOX75788.1;KOX71037.1;KOX73320.1;KOX76312.1 KEGG: 00230+3.5.4.10+2.1.2.3 Purine metabolism 1 KOX71802.1 KEGG: 00565+2.5.1.26 Ether lipid metabolism 1 KOX77488.1 MetaCyc: PWY-7791 UMP biosynthesis III 3 KOX80442.1;KOX80440.1;KOX71473.1 Reactome: R-HSA-110328 Recognition and association of DNA glycosylase with site containing an affected pyrimidine 8 KOX77019.1;KOX74217.1;KOX77330.1;KOX74010.1;KOX75509.1;KOX70328.1;KOX77492.1;KOX74214.1 MetaCyc: PWY-6901 Superpathway of glucose and xylose degradation 8 KOX77687.1;KOX72508.1;KOX81104.1;KOX74974.1;KOX67203.1;KOX77688.1;KOX71859.1;KOX74975.1 MetaCyc: PWY-5484 Glycolysis II (from fructose 6-phosphate) 12 KOX73085.1;KOX74975.1;KOX71859.1;KOX67171.1;KOX74974.1;KOX81104.1;KOX67867.1;KOX67203.1;KOX72508.1;KOX68814.1;KOX76361.1;KOX76362.1 Reactome: R-HSA-8853338 Signaling by FGFR3 point mutants in cancer 1 KOX81204.1 KEGG: 00900+2.2.1.7 Terpenoid backbone biosynthesis 1 KOX69770.1 Reactome: R-HSA-6784531 tRNA processing in the nucleus 41 KOX73226.1;KOX69061.1;KOX72473.1;KOX72787.1;KOX67154.1;KOX75539.1;KOX72429.1;KOX67333.1;KOX68417.1;KOX79436.1;KOX68781.1;KOX75540.1;KOX78031.1;KOX68874.1;KOX79242.1;KOX70336.1;KOX67279.1;KOX76615.1;KOX77609.1;KOX77058.1;KOX71722.1;KOX78183.1;KOX77706.1;KOX71803.1;KOX80341.1;KOX68732.1;KOX67341.1;KOX76516.1;KOX80010.1;KOX80793.1;KOX75986.1;KOX75630.1;KOX78198.1;KOX75811.1;KOX81376.1;KOX79264.1;KOX77505.1;KOX73664.1;KOX75956.1;KOX73131.1;KOX78029.1 KEGG: 00910+4.2.1.1 Nitrogen metabolism 3 KOX68087.1;KOX68932.1;KOX80775.1 Reactome: R-HSA-8851805 MET activates RAS signaling 1 KOX81204.1 KEGG: 00562+2.7.1.158 Inositol phosphate metabolism 2 KOX81098.1;KOX81095.1 Reactome: R-HSA-6814848 Glycerophospholipid catabolism 1 KOX79375.1 Reactome: R-HSA-5625970 RHO GTPases activate KTN1 3 KOX78779.1;KOX70569.1;KOX76191.1 Reactome: R-HSA-8963889 Assembly of active LPL and LIPC lipase complexes 2 KOX73944.1;KOX72214.1