Accession_ID	Pathway_Count	Pathway_IDs	Pathway_Names
XP_046423338.1	2	Reactome: R-HSA-180024;KEGG: 00230+3.1.4.53	"DARPP-32 events";"Purine metabolism"
XP_046424014.1	1	Reactome: R-HSA-8873719	"RAB geranylgeranylation"
XP_046433179.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046428542.1	2	KEGG: 00260+2.1.2.10;KEGG: 00670+2.1.2.10	"Glycine, serine and threonine metabolism";"One carbon pool by folate"
XP_046431870.1	8	Reactome: R-HSA-8856828;Reactome: R-HSA-8856825;Reactome: R-HSA-5099900;Reactome: R-HSA-5140745;Reactome: R-HSA-190873;Reactome: R-HSA-196025;Reactome: R-HSA-432720;Reactome: R-HSA-3928665	"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis";"WNT5A-dependent internalization of FZD4";"WNT5A-dependent internalization of FZD2, FZD5 and ROR2";"Gap junction degradation";"Formation of annular gap junctions";"Lysosome Vesicle Biogenesis";"EPH-ephrin mediated repulsion of cells"
XP_046417147.1	3	Reactome: R-HSA-5657562;Reactome: R-HSA-70350;KEGG: 00051+2.7.1.3	"Essential fructosuria";"Fructose catabolism";"Fructose and mannose metabolism"
XP_046420645.1	11	Reactome: R-HSA-5358606;Reactome: R-HSA-5693568;Reactome: R-HSA-5693579;Reactome: R-HSA-5693607;Reactome: R-HSA-5685942;Reactome: R-HSA-69473;Reactome: R-HSA-6804756;Reactome: R-HSA-5685938;Reactome: R-HSA-5693554;Reactome: R-HSA-5693616;Reactome: R-HSA-5358565	"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"Resolution of D-loop Structures through Holliday Junction Intermediates";"Homologous DNA Pairing and Strand Exchange";"Processing of DNA double-strand break ends";"HDR through Homologous Recombination (HRR)";"G2/M DNA damage checkpoint";"Regulation of TP53 Activity through Phosphorylation";"HDR through Single Strand Annealing (SSA)";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Presynaptic phase of homologous DNA pairing and strand exchange";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)"
XP_046414043.1	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
XP_046411400.1	6	Reactome: R-HSA-380994;Reactome: R-HSA-429958;Reactome: R-HSA-450604;Reactome: R-HSA-450513;Reactome: R-HSA-6791226;Reactome: R-HSA-450385	"ATF4 activates genes in response to endoplasmic reticulum stress";"mRNA decay by 3' to 5' exoribonuclease";"KSRP (KHSRP) binds and destabilizes mRNA";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"Major pathway of rRNA processing in the nucleolus and cytosol";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA"
XP_046413552.1	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
XP_046420719.1	14	MetaCyc: PWY-6433;MetaCyc: PWY-7724;Reactome: R-HSA-75876;MetaCyc: PWY-5972;MetaCyc: PWY-7619;MetaCyc: PWY-7725;MetaCyc: PWY-5080;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7601;MetaCyc: PWY-8041;MetaCyc: PWY-6598;MetaCyc: PWY-7036;MetaCyc: PWY-7602;MetaCyc: PWY-7035	"Hydroxylated fatty acid biosynthesis (plants)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Synthesis of very long-chain fatty acyl-CoAs";"Stearate biosynthesis I (animals)";"Juniperonate biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Very long chain fatty acid biosynthesis I";"Fatty acid elongation";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Ultra-long-chain fatty acid biosynthesis";"Sciadonate biosynthesis";"Very long chain fatty acid biosynthesis II";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"(9Z)-tricosene biosynthesis"
XP_046419584.1	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
XP_046425393.1	5	Reactome: R-HSA-211976;Reactome: R-HSA-2395516;Reactome: R-HSA-5579026;Reactome: R-HSA-1362409;Reactome: R-HSA-196108	"Endogenous sterols";"Electron transport from NADPH to Ferredoxin";"Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)";"Mitochondrial iron-sulfur cluster biogenesis";"Pregnenolone biosynthesis"
XP_046415403.1	1	Reactome: R-HSA-114608	"Platelet degranulation"
XP_046415994.1	4	MetaCyc: PWY-4361;Reactome: R-HSA-1237112;MetaCyc: PWY-7174;KEGG: 00270+5.3.1.23	"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I";"Methionine salvage pathway";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation II";"Cysteine and methionine metabolism"
XP_046427070.1	1	Reactome: R-HSA-6803204	"TP53 Regulates Transcription of Genes Involved in Cytochrome C Release"
XP_046419504.1	3	Reactome: R-HSA-3000157;Reactome: R-HSA-8874081;Reactome: R-HSA-3000171	"Laminin interactions";"MET activates PTK2 signaling";"Non-integrin membrane-ECM interactions"
XP_046424074.1	13	Reactome: R-HSA-1799339;Reactome: R-HSA-72706;Reactome: R-HSA-2408557;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-192823;Reactome: R-HSA-72689;Reactome: R-HSA-9633012;Reactome: R-HSA-72764;Reactome: R-HSA-156902;Reactome: R-HSA-975956;Reactome: R-HSA-6791226;Reactome: R-HSA-975957	"SRP-dependent cotranslational protein targeting to membrane";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Selenocysteine synthesis";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Viral mRNA Translation";"Formation of a pool of free 40S subunits";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Eukaryotic Translation Termination";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
XP_046426126.1	1	Reactome: R-HSA-5658442	"Regulation of RAS by GAPs"
XP_046433086.1	3	Reactome: R-HSA-6807004;Reactome: R-HSA-202427;Reactome: R-HSA-6798695	"Negative regulation of MET activity";"Phosphorylation of CD3 and TCR zeta chains";"Neutrophil degranulation"
XP_046421300.1	7	KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1	"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Relaxin signaling pathway";"Thermogenesis";"Human cytomegalovirus infection"
XP_046422729.1	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
XP_046410554.1	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
XP_046418885.1	8	Reactome: R-HSA-164378;Reactome: R-HSA-432040;Reactome: R-HSA-983231;Reactome: R-HSA-163615;Reactome: R-HSA-180024;Reactome: R-HSA-381676;Reactome: R-HSA-442720;Reactome: R-HSA-5610787	"PKA activation in glucagon signalling";"Vasopressin regulates renal water homeostasis via Aquaporins";"Factors involved in megakaryocyte development and platelet production";"PKA activation";"DARPP-32 events";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"CREB1 phosphorylation through the activation of Adenylate Cyclase";"Hedgehog 'off' state"
XP_046423731.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_046418388.1	1	Reactome: R-HSA-1483191	"Synthesis of PC"
XP_046427485.1	2	Reactome: R-HSA-5576893;Reactome: R-HSA-5576892	"Phase 2 - plateau phase";"Phase 0 - rapid depolarisation"
XP_046415161.1	2	MetaCyc: PWY-7221;KEGG: 00230+2.7.4.8	"Guanosine ribonucleotides de novo biosynthesis";"Purine metabolism"
XP_046425289.1	17	KEGG: 05163+2.7.11.1;Reactome: R-HSA-6804756;Reactome: R-HSA-69473;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;Reactome: R-HSA-6796648;KEGG: 04151+2.7.11.1;Reactome: R-HSA-176187;Reactome: R-HSA-5693616;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;Reactome: R-HSA-3371453;Reactome: R-HSA-6783310;Reactome: R-HSA-1221632;Reactome: R-HSA-5685938;KEGG: 05165+2.7.11.1;Reactome: R-HSA-5693607	"Human cytomegalovirus infection";"Regulation of TP53 Activity through Phosphorylation";"G2/M DNA damage checkpoint";"Relaxin signaling pathway";"mTOR signaling pathway";"TP53 Regulates Transcription of DNA Repair Genes";"PI3K-Akt signaling pathway";"Activation of ATR in response to replication stress";"Presynaptic phase of homologous DNA pairing and strand exchange";"Thermogenesis";"Human immunodeficiency virus 1 infection";"Regulation of HSF1-mediated heat shock response";"Fanconi Anemia Pathway";"Meiotic synapsis";"HDR through Single Strand Annealing (SSA)";"Human papillomavirus infection";"Processing of DNA double-strand break ends"
XP_046421172.1	2	KEGG: 00480+1.11.1.15;Reactome: R-HSA-3299685	"Glutathione metabolism";"Detoxification of Reactive Oxygen Species"
XP_046416967.1	1	Reactome: R-HSA-191859	"snRNP Assembly"
XP_046423792.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_046427986.1	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276	"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination"
XP_046421328.1	7	KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1	"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Relaxin signaling pathway";"Thermogenesis";"Human cytomegalovirus infection"
XP_046415171.1	2	KEGG: 00230+2.7.4.8;MetaCyc: PWY-7221	"Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis"
XP_046418581.1	5	Reactome: R-HSA-1222556;Reactome: R-HSA-77387;Reactome: R-HSA-9639288;Reactome: R-HSA-917977;Reactome: R-HSA-983712	"ROS and RNS production in phagocytes";"Insulin receptor recycling";"Amino acids regulate mTORC1";"Transferrin endocytosis and recycling";"Ion channel transport"
XP_046413456.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_046435164.1	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
XP_046427309.1	56	Reactome: R-HSA-349425;Reactome: R-HSA-174084;Reactome: R-HSA-5689880;Reactome: R-HSA-8951664;Reactome: R-HSA-4641257;Reactome: R-HSA-4608870;Reactome: R-HSA-75815;Reactome: R-HSA-202424;Reactome: R-HSA-1236978;Reactome: R-HSA-5610785;Reactome: R-HSA-180585;Reactome: R-HSA-5678895;Reactome: R-HSA-8939236;Reactome: R-HSA-983168;Reactome: R-HSA-5658442;Reactome: R-HSA-5607761;Reactome: R-HSA-174184;Reactome: R-HSA-8939902;Reactome: R-HSA-174154;Reactome: R-HSA-2467813;Reactome: R-HSA-8854050;Reactome: R-HSA-9020702;Reactome: R-HSA-5687128;Reactome: R-HSA-174113;Reactome: R-HSA-5607764;Reactome: R-HSA-187577;Reactome: R-HSA-180534;Reactome: R-HSA-5689603;Reactome: R-HSA-68827;Reactome: R-HSA-8852276;Reactome: R-HSA-5610783;Reactome: R-HSA-8948751;Reactome: R-HSA-1234176;Reactome: R-HSA-69481;Reactome: R-HSA-5632684;Reactome: R-HSA-211733;Reactome: R-HSA-4641258;Reactome: R-HSA-1236974;Reactome: R-HSA-5610780;Reactome: R-HSA-450408;Reactome: R-HSA-5668541;Reactome: R-HSA-350562;Reactome: R-HSA-9010553;Reactome: R-HSA-8941858;Reactome: R-HSA-69601;Reactome: R-HSA-5358346;Reactome: R-HSA-69017;Reactome: R-HSA-9604323;Reactome: R-HSA-5676590;Reactome: R-HSA-5362768;Reactome: R-HSA-2871837;Reactome: R-HSA-174178;Reactome: R-HSA-195253;Reactome: R-HSA-1169091;Reactome: R-HSA-382556;Reactome: R-HSA-68949	"Autodegradation of the E3 ubiquitin ligase COP1";"Autodegradation of Cdh1 by Cdh1:APC/C";"Ub-specific processing proteases";"Neddylation";"Degradation of AXIN";"Asymmetric localization of PCP proteins";"Ubiquitin-dependent degradation of Cyclin D";"Downstream TCR signaling";"Cross-presentation of soluble exogenous antigens (endosomes)";"GLI3 is processed to GLI3R by the proteasome";"Vif-mediated degradation of APOBEC3G";"Defective CFTR causes cystic fibrosis";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Antigen processing: Ubiquitination & Proteasome degradation";"Regulation of RAS by GAPs";"Dectin-1 mediated noncanonical NF-kB signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Regulation of RUNX2 expression and activity";"APC/C:Cdc20 mediated degradation of Securin";"Separation of Sister Chromatids";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Interleukin-1 signaling";"MAPK6/MAPK4 signaling";"SCF-beta-TrCP mediated degradation of Emi1";"CLEC7A (Dectin-1) signaling";"SCF(Skp2)-mediated degradation of p27/p21";"Vpu mediated degradation of CD4";"UCH proteinases";"CDT1 association with the CDC6:ORC:origin complex";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Degradation of GLI2 by the proteasome";"Regulation of PTEN stability and activity";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"G2/M Checkpoints";"Hedgehog 'on' state";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Degradation of DVL";"ER-Phagosome pathway";"Degradation of GLI1 by the proteasome";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"TNFR2 non-canonical NF-kB pathway";"Regulation of ornithine decarboxylase (ODC)";"Regulation of expression of SLITs and ROBOs";"Regulation of RUNX3 expression and activity";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Hedgehog ligand biogenesis";"CDK-mediated phosphorylation and removal of Cdc6";"Negative regulation of NOTCH4 signaling";"NIK-->noncanonical NF-kB signaling";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"FCERI mediated NF-kB activation";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Degradation of beta-catenin by the destruction complex";"Activation of NF-kappaB in B cells";"ABC-family proteins mediated transport";"Orc1 removal from chromatin"
XP_046435562.1	6	Reactome: R-HSA-5358565;Reactome: R-HSA-6796648;Reactome: R-HSA-5632928;Reactome: R-HSA-5358606;Reactome: R-HSA-5632927;Reactome: R-HSA-5632968	"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"TP53 Regulates Transcription of DNA Repair Genes";"Defective Mismatch Repair Associated With MSH2";"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"Defective Mismatch Repair Associated With MSH3";"Defective Mismatch Repair Associated With MSH6"
XP_046421897.1	3	Reactome: R-HSA-189451;MetaCyc: PWY-7856;KEGG: 00860+2.5.1.141	"Heme biosynthesis";"Heme a biosynthesis";"Porphyrin and chlorophyll metabolism"
XP_046424195.1	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
XP_046422710.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_046413278.1	16	Reactome: R-HSA-8853884;Reactome: R-HSA-5687128;Reactome: R-HSA-9022692;Reactome: R-HSA-426496;Reactome: R-HSA-9029569;Reactome: R-HSA-2559580;Reactome: R-HSA-8934593;Reactome: R-HSA-4086398;Reactome: R-HSA-8936459;Reactome: R-HSA-9018519;Reactome: R-HSA-2559585;Reactome: R-HSA-8948700;Reactome: R-HSA-5628897;Reactome: R-HSA-1912408;Reactome: R-HSA-8943723;Reactome: R-HSA-8986944	"Transcriptional Regulation by VENTX";"MAPK6/MAPK4 signaling";"Regulation of MECP2 expression and activity";"Post-transcriptional silencing by small RNAs";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Oxidative Stress Induced Senescence";"Regulation of RUNX1 Expression and Activity";"Ca2+ pathway";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Estrogen-dependent gene expression";"Oncogene Induced Senescence";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"TP53 Regulates Metabolic Genes";"Pre-NOTCH Transcription and Translation";"Regulation of PTEN mRNA translation";"Transcriptional Regulation by MECP2"
XP_046435687.1	2	Reactome: R-HSA-196783;KEGG: 00770+6.3.2.5	"Coenzyme A biosynthesis";"Pantothenate and CoA biosynthesis"
XP_046429112.1	19	Reactome: R-HSA-975634;Reactome: R-HSA-202733;Reactome: R-HSA-3000471;Reactome: R-HSA-5686938;Reactome: R-HSA-8964046;Reactome: R-HSA-3000480;Reactome: R-HSA-3000497;Reactome: R-HSA-8963888;Reactome: R-HSA-8866423;Reactome: R-HSA-8964041;Reactome: R-HSA-381426;Reactome: R-HSA-3000484;Reactome: R-HSA-8856828;Reactome: R-HSA-432142;Reactome: R-HSA-8964026;Reactome: R-HSA-8963901;Reactome: R-HSA-8957275;Reactome: R-HSA-8964038;Reactome: R-HSA-8856825	"Retinoid metabolism and transport";"Cell surface interactions at the vascular wall";"Scavenging by Class B Receptors";"Regulation of TLR by endogenous ligand";"VLDL clearance";"Scavenging by Class A Receptors";"Scavenging by Class H Receptors";"Chylomicron assembly";"VLDL assembly";"LDL remodeling";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"Scavenging by Class F Receptors";"Clathrin-mediated endocytosis";"Platelet sensitization by LDL";"Chylomicron clearance";"Chylomicron remodeling";"Post-translational protein phosphorylation";"LDL clearance";"Cargo recognition for clathrin-mediated endocytosis"
XP_046415609.1	14	MetaCyc: PWY-7587;MetaCyc: PWY-7411;Reactome: R-HSA-1483166;MetaCyc: PWY-5667;MetaCyc: PWY-8055;KEGG: 00561+2.3.1.51;MetaCyc: PWY-8051;KEGG: 00564+2.3.1.51;MetaCyc: PWY-6453;MetaCyc: PWY-7417;MetaCyc: PWY-5981;MetaCyc: PWY-8053;MetaCyc: PWY-7589;MetaCyc: PWY-7782	"Oleate biosynthesis III (cyanobacteria)";"Phosphatidate biosynthesis (yeast)";"Synthesis of PA";"CDP-diacylglycerol biosynthesis I";"Palmitoyl ethanolamide biosynthesis";"Glycerolipid metabolism";"Anandamide biosynthesis I";"Glycerophospholipid metabolism";"Stigma estolide biosynthesis";"Phospholipid remodeling (phosphatidate, yeast)";"CDP-diacylglycerol biosynthesis III";"Anandamide biosynthesis II";"Palmitoleate biosynthesis III (cyanobacteria)";"Plasmalogen biosynthesis"
XP_046418474.1	1	Reactome: R-HSA-8854214	"TBC/RABGAPs"
XP_046427794.1	10	MetaCyc: PWY-6842;MetaCyc: PWY-5826;KEGG: 00480+2.3.2.2+3.4.19.13;MetaCyc: PWY-7559;KEGG: 00430+2.3.2.2;KEGG: 00460+2.3.2.2;MetaCyc: PWY-4041;MetaCyc: PWY-8001;MetaCyc: PWY-7112;MetaCyc: PWY-4061	"Glutathione-mediated detoxification II";"Hypoglycin biosynthesis";"Glutathione metabolism";"Glutathione degradation (DUG pathway";"Taurine and hypotaurine metabolism";"Cyanoamino acid metabolism";"Gamma-glutamyl cycle";"Felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis";"4-hydroxy-2-nonenal detoxification";"Glutathione-mediated detoxification I"
XP_046428245.1	1	Reactome: R-HSA-83936	"Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"
XP_046424012.1	1	Reactome: R-HSA-8873719	"RAB geranylgeranylation"
XP_046420334.1	7	MetaCyc: PWY-5469;MetaCyc: PWY-5466;KEGG: 00940+1.11.1.7;MetaCyc: PWY-7445;MetaCyc: PWY-7214;MetaCyc: PWY-6824;MetaCyc: PWY-5461	"Sesamin biosynthesis";"Matairesinol biosynthesis";"Phenylpropanoid biosynthesis";"Luteolin triglucuronide degradation";"Baicalein degradation (hydrogen peroxide detoxification)";"Justicidin B biosynthesis";"Betanidin degradation"
XP_046434389.1	2	Reactome: R-HSA-72163;Reactome: R-HSA-430039	"mRNA Splicing - Major Pathway";"mRNA decay by 5' to 3' exoribonuclease"
XP_046427824.1	1	Reactome: R-HSA-429958	"mRNA decay by 3' to 5' exoribonuclease"
XP_046436718.1	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
XP_046421962.1	2	Reactome: R-HSA-418457;Reactome: R-HSA-1296052	"cGMP effects";"Ca2+ activated K+ channels"
XP_046421924.1	12	KEGG: 00565+3.1.1.4;MetaCyc: PWY-6803;MetaCyc: PWY-8051;KEGG: 00592+3.1.1.4;MetaCyc: PWY-7783;KEGG: 00590+3.1.1.4;MetaCyc: PWY-8053;MetaCyc: PWY-7416;MetaCyc: PWY-7409;KEGG: 00564+3.1.1.4;MetaCyc: PWY-7417;KEGG: 00591+3.1.1.4	"Ether lipid metabolism";"Phosphatidylcholine acyl editing";"Anandamide biosynthesis I";"alpha-Linolenic acid metabolism";"Plasmalogen degradation";"Arachidonic acid metabolism";"Anandamide biosynthesis II";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Glycerophospholipid metabolism";"Phospholipid remodeling (phosphatidate, yeast)";"Linoleic acid metabolism"
XP_046435327.1	2	Reactome: R-HSA-8951664;Reactome: R-HSA-983168	"Neddylation";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046431331.1	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
XP_046433283.1	52	Reactome: R-HSA-75953;Reactome: R-HSA-427413;Reactome: R-HSA-76066;Reactome: R-HSA-167246;Reactome: R-HSA-72165;Reactome: R-HSA-73980;Reactome: R-HSA-167238;Reactome: R-HSA-73779;Reactome: R-HSA-6782135;Reactome: R-HSA-5250924;Reactome: R-HSA-167160;Reactome: R-HSA-167172;Reactome: R-HSA-5601884;Reactome: R-HSA-73863;Reactome: R-HSA-76071;Reactome: R-HSA-674695;Reactome: R-HSA-167242;Reactome: R-HSA-76061;Reactome: R-HSA-167200;Reactome: R-HSA-6796648;Reactome: R-HSA-77075;Reactome: R-HSA-73772;Reactome: R-HSA-167290;Reactome: R-HSA-167152;Reactome: R-HSA-6803529;Reactome: R-HSA-1834949;Reactome: R-HSA-749476;Reactome: R-HSA-6781823;Reactome: R-HSA-6807505;Reactome: R-HSA-167162;Reactome: R-HSA-113418;Reactome: R-HSA-6782210;Reactome: R-HSA-203927;Reactome: R-HSA-6781827;Reactome: R-HSA-167158;Reactome: R-HSA-167287;Reactome: R-HSA-73762;Reactome: R-HSA-5578749;Reactome: R-HSA-76042;Reactome: R-HSA-5617472;Reactome: R-HSA-72203;Reactome: R-HSA-75955;Reactome: R-HSA-73780;Reactome: R-HSA-112382;Reactome: R-HSA-167243;Reactome: R-HSA-72163;Reactome: R-HSA-72086;Reactome: R-HSA-73776;Reactome: R-HSA-168325;Reactome: R-HSA-167161;Reactome: R-HSA-8851708;Reactome: R-HSA-9018519	"RNA Polymerase II Transcription Initiation";"NoRC negatively regulates rRNA expression";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"Tat-mediated elongation of the HIV-1 transcript";"mRNA Splicing - Minor Pathway";"RNA Polymerase III Transcription Termination";"Pausing and recovery of Tat-mediated HIV elongation";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Dual incision in TC-NER";"B-WICH complex positively regulates rRNA expression";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Transcription of the HIV genome";"PIWI-interacting RNA (piRNA) biogenesis";"RNA Polymerase I Transcription Termination";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase II Pre-transcription Events";"Abortive elongation of HIV-1 transcript in the absence of Tat";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Pol II CTD phosphorylation and interaction with CE";"RNA Polymerase I Promoter Escape";"Pausing and recovery of HIV elongation";"Formation of HIV elongation complex in the absence of HIV Tat";"FGFR2 alternative splicing";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Abortive And Retractive Initiation";"Formation of TC-NER Pre-Incision Complex";"RNA polymerase II transcribes snRNA genes";"RNA Polymerase II HIV Promoter Escape";"Formation of the Early Elongation Complex";"Gap-filling DNA repair synthesis and ligation in TC-NER";"MicroRNA (miRNA) biogenesis";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Formation of the HIV-1 Early Elongation Complex";"HIV elongation arrest and recovery";"RNA Polymerase I Transcription Initiation";"Transcriptional regulation by small RNAs";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Processing of Capped Intron-Containing Pre-mRNA";"RNA Polymerase II Transcription Elongation";"RNA Polymerase III Chain Elongation";"Formation of RNA Pol II elongation complex";"Tat-mediated HIV elongation arrest and recovery";"mRNA Splicing - Major Pathway";"mRNA Capping";"RNA Polymerase II Promoter Escape";"Viral Messenger RNA Synthesis";"HIV Transcription Initiation";"Signaling by FGFR2 IIIa TM";"Estrogen-dependent gene expression"
XP_046416950.1	1	Reactome: R-HSA-9037629	"Lewis blood group biosynthesis"
XP_046424141.1	2	Reactome: R-HSA-1268020;Reactome: R-HSA-8869496	"Mitochondrial protein import";"TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation"
XP_046414683.1	1	Reactome: R-HSA-432720	"Lysosome Vesicle Biogenesis"
XP_046421295.1	3	Reactome: R-HSA-5423646;MetaCyc: PWY-7533;Reactome: R-HSA-2142691	"Aflatoxin activation and detoxification";"Gliotoxin biosynthesis";"Synthesis of Leukotrienes (LT) and Eoxins (EX)"
XP_046429820.1	2	Reactome: R-HSA-5635838;Reactome: R-HSA-5632681	"Activation of SMO";"Ligand-receptor interactions"
XP_046423035.1	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046410502.1	2	Reactome: R-HSA-5682910;Reactome: R-HSA-5250971	"LGI-ADAM interactions";"Toxicity of botulinum toxin type C (BoNT/C)"
XP_046427738.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_046422257.1	6	KEGG: 04070+2.7.11.13;Reactome: R-HSA-418597;Reactome: R-HSA-5099900;Reactome: R-HSA-416993;Reactome: R-HSA-114516;Reactome: R-HSA-76005	"Phosphatidylinositol signaling system";"G alpha (z) signalling events";"WNT5A-dependent internalization of FZD4";"Trafficking of GluR2-containing AMPA receptors";"Disinhibition of SNARE formation";"Response to elevated platelet cytosolic Ca2+"
XP_046423760.1	8	Reactome: R-HSA-68827;Reactome: R-HSA-176187;Reactome: R-HSA-68962;Reactome: R-HSA-68949;Reactome: R-HSA-68867;Reactome: R-HSA-113507;Reactome: R-HSA-68689;Reactome: R-HSA-68616	"CDT1 association with the CDC6:ORC:origin complex";"Activation of ATR in response to replication stress";"Activation of the pre-replicative complex";"Orc1 removal from chromatin";"Assembly of the pre-replicative complex";"E2F-enabled inhibition of pre-replication complex formation";"CDC6 association with the ORC:origin complex";"Assembly of the ORC complex at the origin of replication"
XP_046426431.1	9	Reactome: R-HSA-5689880;Reactome: R-HSA-8856825;Reactome: R-HSA-9615710;Reactome: R-HSA-9613829;Reactome: R-HSA-5678895;Reactome: R-HSA-8856828;Reactome: R-HSA-5627083;Reactome: R-HSA-382556;Reactome: R-HSA-9646399	"Ub-specific processing proteases";"Cargo recognition for clathrin-mediated endocytosis";"Late endosomal microautophagy";"Chaperone Mediated Autophagy";"Defective CFTR causes cystic fibrosis";"Clathrin-mediated endocytosis";"RHO GTPases regulate CFTR trafficking";"ABC-family proteins mediated transport";"Aggrephagy"
XP_046436337.1	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
XP_046417373.1	6	Reactome: R-HSA-674695;Reactome: R-HSA-5632684;Reactome: R-HSA-75955;Reactome: R-HSA-8866654;Reactome: R-HSA-112382;Reactome: R-HSA-201722	"RNA Polymerase II Pre-transcription Events";"Hedgehog 'on' state";"RNA Polymerase II Transcription Elongation";"E3 ubiquitin ligases ubiquitinate target proteins";"Formation of RNA Pol II elongation complex";"Formation of the beta-catenin:TCF transactivating complex"
XP_046416855.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_046416083.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-5628897	"Respiratory electron transport";"TP53 Regulates Metabolic Genes"
XP_046409570.1	3	Reactome: R-HSA-1989781;Reactome: R-HSA-381340;Reactome: R-HSA-212436	"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation";"Generic Transcription Pathway"
XP_046416587.1	5	Reactome: R-HSA-1834941;Reactome: R-HSA-3270619;Reactome: R-HSA-3249367;Reactome: R-HSA-3134975;Reactome: R-HSA-6798695	"STING mediated induction of host immune responses";"IRF3-mediated induction of type I IFN";"STAT6-mediated induction of chemokines";"Regulation of innate immune responses to cytosolic DNA";"Neutrophil degranulation"
XP_046418134.1	1	Reactome: R-HSA-3214858	"RMTs methylate histone arginines"
XP_046418370.1	2	Reactome: R-HSA-6783310;Reactome: R-HSA-5693568	"Fanconi Anemia Pathway";"Resolution of D-loop Structures through Holliday Junction Intermediates"
XP_046415764.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_046423843.1	1	Reactome: R-HSA-3214858	"RMTs methylate histone arginines"
XP_046413377.1	3	Reactome: R-HSA-73843;KEGG: 00230+2.7.6.1;KEGG: 00030+2.7.6.1	"5-Phosphoribose 1-diphosphate biosynthesis";"Purine metabolism";"Pentose phosphate pathway"
XP_046414345.1	13	MetaCyc: PWY-6351;MetaCyc: PWY-7039;Reactome: R-HSA-2424491;Reactome: R-HSA-2871809;Reactome: R-HSA-202433;KEGG: 00562+3.1.4.11;Reactome: R-HSA-9027277;Reactome: R-HSA-1855204;Reactome: R-HSA-2029485;Reactome: R-HSA-2871796;KEGG: 04070+3.1.4.11;MetaCyc: PWY-6367;MetaCyc: PWY-8052	"D-myo-inositol (1,4,5)-trisphosphate biosynthesis";"Phosphatidate metabolism, as a signaling molecule";"DAP12 signaling";"FCERI mediated Ca+2 mobilization";"Generation of second messenger molecules";"Inositol phosphate metabolism";"Erythropoietin activates Phospholipase C gamma (PLCG)";"Synthesis of IP3 and IP4 in the cytosol";"Role of phospholipids in phagocytosis";"FCERI mediated MAPK activation";"Phosphatidylinositol signaling system";"D-myo-inositol-5-phosphate metabolism";"2-arachidonoylglycerol biosynthesis"
XP_046431122.1	2	Reactome: R-HSA-390522;Reactome: R-HSA-445355	"Striated Muscle Contraction";"Smooth Muscle Contraction"
XP_046430616.1	3	Reactome: R-HSA-6798695;Reactome: R-HSA-6807004;Reactome: R-HSA-202427	"Neutrophil degranulation";"Negative regulation of MET activity";"Phosphorylation of CD3 and TCR zeta chains"
XP_046411250.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_046427364.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046431503.1	3	MetaCyc: PWY-6619;KEGG: 00230+2.7.1.20;Reactome: R-HSA-74217	"Adenine and adenosine salvage VI";"Purine metabolism";"Purine salvage"
XP_046412693.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046412739.1	1	Reactome: R-HSA-1799339	"SRP-dependent cotranslational protein targeting to membrane"
XP_046427489.1	2	Reactome: R-HSA-5576892;Reactome: R-HSA-5576893	"Phase 0 - rapid depolarisation";"Phase 2 - plateau phase"
XP_046427421.1	9	KEGG: 05163+2.7.11.1;Reactome: R-HSA-6804756;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;Reactome: R-HSA-6782315;KEGG: 04151+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1	"Human cytomegalovirus infection";"Regulation of TP53 Activity through Phosphorylation";"Relaxin signaling pathway";"mTOR signaling pathway";"tRNA modification in the nucleus and cytosol";"PI3K-Akt signaling pathway";"Thermogenesis";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection"
XP_046426970.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046428314.1	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
XP_046420640.1	2	Reactome: R-HSA-379726;KEGG: 00970+6.1.1.5	"Mitochondrial tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis"
XP_046425051.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_046422715.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_046420814.1	5	Reactome: R-HSA-9633012;KEGG: 00250+6.3.5.4;Reactome: R-HSA-8963693;Reactome: R-HSA-380994;Reactome: R-HSA-9648895	"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Alanine, aspartate and glutamate metabolism";"Aspartate and asparagine metabolism";"ATF4 activates genes in response to endoplasmic reticulum stress";"Response of EIF2AK1 (HRI) to heme deficiency"
XP_046428325.1	3	MetaCyc: PWY-7887;MetaCyc: PWY-7892;Reactome: R-HSA-6787450	"Protein SAMPylation and SAMP-mediated thiolation";"Trna-uridine 2-thiolation and selenation (bacteria)";"tRNA modification in the mitochondrion"
XP_046430683.1	3	MetaCyc: PWY-3961;KEGG: 00770+2.7.1.33;Reactome: R-HSA-196783	"Phosphopantothenate biosynthesis II";"Pantothenate and CoA biosynthesis";"Coenzyme A biosynthesis"
XP_046436054.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_046431325.1	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
XP_046432764.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_046429189.1	6	MetaCyc: PWY-7433;MetaCyc: PWY-7290;KEGG: 00514+2.4.1.122;Reactome: R-HSA-913709;KEGG: 00512+2.4.1.122;Reactome: R-HSA-5083632	"Mucin core 1 and core 2 O-glycosylation";"Escherichia coli serotype O86 O-antigen biosynthesis";"Other types of O-glycan biosynthesis";"O-linked glycosylation of mucins";"Mucin type O-glycan biosynthesis";"Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)"
XP_046422659.1	4	Reactome: R-HSA-159236;Reactome: R-HSA-72187;Reactome: R-HSA-72163;Reactome: R-HSA-73856	"Transport of Mature mRNA derived from an Intron-Containing Transcript";"mRNA 3'-end processing";"mRNA Splicing - Major Pathway";"RNA Polymerase II Transcription Termination"
XP_046419773.1	1	Reactome: R-HSA-390522	"Striated Muscle Contraction"
XP_046422924.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046427911.1	6	MetaCyc: PWY-7039;KEGG: 00561+2.7.1.107;MetaCyc: PWY-7817;Reactome: R-HSA-114508;KEGG: 00564+2.7.1.107;KEGG: 04070+2.7.1.107	"Phosphatidate metabolism, as a signaling molecule";"Glycerolipid metabolism";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Effects of PIP2 hydrolysis";"Glycerophospholipid metabolism";"Phosphatidylinositol signaling system"
XP_046417882.1	3	Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-212436	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"Generic Transcription Pathway"
XP_046428321.1	3	KEGG: 00730+3.1.3.1;MetaCyc: PWY-5491;KEGG: 00790+3.1.3.1	"Thiamine metabolism";"Diethylphosphate degradation";"Folate biosynthesis"
XP_046434714.1	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
XP_046422049.1	1	Reactome: R-HSA-425561	"Sodium/Calcium exchangers"
XP_046420233.1	10	Reactome: R-HSA-8936459;Reactome: R-HSA-9615017;Reactome: R-HSA-400206;Reactome: R-HSA-9022702;Reactome: R-HSA-9022538;Reactome: R-HSA-3899300;Reactome: R-HSA-9022699;Reactome: R-HSA-9022692;Reactome: R-HSA-427413;Reactome: R-HSA-983231	"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"Regulation of lipid metabolism by PPARalpha";"MECP2 regulates transcription of neuronal ligands";"Loss of MECP2 binding ability to 5mC-DNA";"SUMOylation of transcription cofactors";"MECP2 regulates neuronal receptors and channels";"Regulation of MECP2 expression and activity";"NoRC negatively regulates rRNA expression";"Factors involved in megakaryocyte development and platelet production"
XP_046430917.1	5	MetaCyc: PWY-5531;KEGG: 00860+4.1.1.37;MetaCyc: PWY-7766;MetaCyc: PWY-7159;Reactome: R-HSA-189451	"3,8-divinyl-chlorophyllide a biosynthesis II (anaerobic)";"Porphyrin and chlorophyll metabolism";"Heme b biosynthesis IV (Gram-positive bacteria)";"3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent)";"Heme biosynthesis"
XP_046428420.1	7	KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1	"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Relaxin signaling pathway";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Human cytomegalovirus infection";"Thermogenesis"
XP_046427566.1	57	Reactome: R-HSA-5610783;Reactome: R-HSA-8852276;Reactome: R-HSA-69481;Reactome: R-HSA-1234176;Reactome: R-HSA-8948751;Reactome: R-HSA-180534;Reactome: R-HSA-187577;Reactome: R-HSA-5607764;Reactome: R-HSA-68827;Reactome: R-HSA-5689603;Reactome: R-HSA-5687128;Reactome: R-HSA-174113;Reactome: R-HSA-8854050;Reactome: R-HSA-9020702;Reactome: R-HSA-195253;Reactome: R-HSA-174178;Reactome: R-HSA-2871837;Reactome: R-HSA-1169091;Reactome: R-HSA-382556;Reactome: R-HSA-68949;Reactome: R-HSA-9604323;Reactome: R-HSA-5676590;Reactome: R-HSA-5362768;Reactome: R-HSA-5358346;Reactome: R-HSA-69601;Reactome: R-HSA-69017;Reactome: R-HSA-350562;Reactome: R-HSA-8941858;Reactome: R-HSA-9010553;Reactome: R-HSA-5668541;Reactome: R-HSA-4641258;Reactome: R-HSA-211733;Reactome: R-HSA-5632684;Reactome: R-HSA-5610780;Reactome: R-HSA-450408;Reactome: R-HSA-1236974;Reactome: R-HSA-8939236;Reactome: R-HSA-5610785;Reactome: R-HSA-5678895;Reactome: R-HSA-180585;Reactome: R-HSA-75815;Reactome: R-HSA-202424;Reactome: R-HSA-4608870;Reactome: R-HSA-4641257;Reactome: R-HSA-1236978;Reactome: R-HSA-349425;Reactome: R-HSA-8951664;Reactome: R-HSA-5689880;Reactome: R-HSA-174084;Reactome: R-HSA-2467813;Reactome: R-HSA-8939902;Reactome: R-HSA-174184;Reactome: R-HSA-174154;Reactome: R-HSA-6798695;Reactome: R-HSA-5658442;Reactome: R-HSA-983168;Reactome: R-HSA-5607761	"Degradation of GLI2 by the proteasome";"The role of GTSE1 in G2/M progression after G2 checkpoint";"G2/M Checkpoints";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of PTEN stability and activity";"Vpu mediated degradation of CD4";"SCF(Skp2)-mediated degradation of p27/p21";"CLEC7A (Dectin-1) signaling";"CDT1 association with the CDC6:ORC:origin complex";"UCH proteinases";"MAPK6/MAPK4 signaling";"SCF-beta-TrCP mediated degradation of Emi1";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Interleukin-1 signaling";"Degradation of beta-catenin by the destruction complex";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"FCERI mediated NF-kB activation";"Activation of NF-kappaB in B cells";"ABC-family proteins mediated transport";"Orc1 removal from chromatin";"Negative regulation of NOTCH4 signaling";"NIK-->noncanonical NF-kB signaling";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Hedgehog ligand biogenesis";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"CDK-mediated phosphorylation and removal of Cdc6";"Regulation of ornithine decarboxylase (ODC)";"Regulation of RUNX3 expression and activity";"Regulation of expression of SLITs and ROBOs";"TNFR2 non-canonical NF-kB pathway";"Degradation of DVL";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Hedgehog 'on' state";"Degradation of GLI1 by the proteasome";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"ER-Phagosome pathway";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"GLI3 is processed to GLI3R by the proteasome";"Defective CFTR causes cystic fibrosis";"Vif-mediated degradation of APOBEC3G";"Ubiquitin-dependent degradation of Cyclin D";"Downstream TCR signaling";"Asymmetric localization of PCP proteins";"Degradation of AXIN";"Cross-presentation of soluble exogenous antigens (endosomes)";"Autodegradation of the E3 ubiquitin ligase COP1";"Neddylation";"Ub-specific processing proteases";"Autodegradation of Cdh1 by Cdh1:APC/C";"Separation of Sister Chromatids";"Regulation of RUNX2 expression and activity";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"APC/C:Cdc20 mediated degradation of Securin";"Neutrophil degranulation";"Regulation of RAS by GAPs";"Antigen processing: Ubiquitination & Proteasome degradation";"Dectin-1 mediated noncanonical NF-kB signaling"
XP_046413023.1	11	MetaCyc: PWY-5154;KEGG: 00250+2.1.3.2;KEGG: 00240+2.1.3.2;MetaCyc: PWY-7790;Reactome: R-HSA-500753;KEGG: 00250+6.3.5.5;MetaCyc: PWY-7400;KEGG: 00240+3.5.2.3;MetaCyc: PWY-5686;MetaCyc: PWY-7791;KEGG: 00240+6.3.5.5	"L-arginine biosynthesis III (via N-acetyl-L-citrulline)";"Alanine, aspartate and glutamate metabolism";"Pyrimidine metabolism";"UMP biosynthesis II";"Pyrimidine biosynthesis";"Alanine, aspartate and glutamate metabolism";"L-arginine biosynthesis IV (archaebacteria)";"Pyrimidine metabolism";"UMP biosynthesis I";"UMP biosynthesis III";"Pyrimidine metabolism"
XP_046435079.1	7	KEGG: 04926+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1	"Relaxin signaling pathway";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Human cytomegalovirus infection";"Thermogenesis";"PI3K-Akt signaling pathway";"mTOR signaling pathway"
XP_046414897.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046423562.1	1	Reactome: R-HSA-6784531	"tRNA processing in the nucleus"
XP_046436179.1	17	Reactome: R-HSA-5689880;Reactome: R-HSA-937042;Reactome: R-HSA-450321;Reactome: R-HSA-9020702;Reactome: R-HSA-9645460;Reactome: R-HSA-168638;Reactome: R-HSA-202424;Reactome: R-HSA-4086398;Reactome: R-HSA-5357956;Reactome: R-HSA-445989;Reactome: R-HSA-5607764;Reactome: R-HSA-450302;Reactome: R-HSA-975163;Reactome: R-HSA-937072;Reactome: R-HSA-9014325;Reactome: R-HSA-1169091;Reactome: R-HSA-2871837	"Ub-specific processing proteases";"IRAK2 mediated activation of TAK1 complex";"JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1";"Interleukin-1 signaling";"Alpha-protein kinase 1 signaling pathway";"NOD1/2 Signaling Pathway";"Downstream TCR signaling";"Ca2+ pathway";"TNFR1-induced NFkappaB signaling pathway";"TAK1 activates NFkB by phosphorylation and activation of IKKs complex";"CLEC7A (Dectin-1) signaling";"activated TAK1 mediates p38 MAPK activation";"IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation";"TRAF6-mediated induction of TAK1 complex within TLR4 complex";"TICAM1,TRAF6-dependent induction of TAK1 complex";"Activation of NF-kappaB in B cells";"FCERI mediated NF-kB activation"
XP_046432949.1	1	Reactome: R-HSA-110362	"POLB-Dependent Long Patch Base Excision Repair"
XP_046412688.1	5	MetaCyc: PWY-7822;MetaCyc: PWY-6902;MetaCyc: PWY-6855;KEGG: 00520+3.2.1.14;Reactome: R-HSA-189085	"Chitin degradation III (Serratia)";"Chitin degradation II (Vibrio)";"Chitin degradation I (archaea)";"Amino sugar and nucleotide sugar metabolism";"Digestion of dietary carbohydrate"
XP_046409933.1	14	MetaCyc: PWY-8055;MetaCyc: PWY-8051;MetaCyc: PWY-6453;Reactome: R-HSA-75109;Reactome: R-HSA-4419969;KEGG: 00565+3.1.3.4;MetaCyc: PWY-8052;Reactome: R-HSA-1483213;KEGG: 00561+3.1.3.4;MetaCyc: PWY-8053;MetaCyc: PWY-7782;Reactome: R-HSA-1483191;KEGG: 00564+3.1.3.4;KEGG: 00600+3.1.3.4	"Palmitoyl ethanolamide biosynthesis";"Anandamide biosynthesis I";"Stigma estolide biosynthesis";"Triglyceride biosynthesis";"Depolymerisation of the Nuclear Lamina";"Ether lipid metabolism";"2-arachidonoylglycerol biosynthesis";"Synthesis of PE";"Glycerolipid metabolism";"Anandamide biosynthesis II";"Plasmalogen biosynthesis";"Synthesis of PC";"Glycerophospholipid metabolism";"Sphingolipid metabolism"
XP_046436147.1	2	Reactome: R-HSA-168276;Reactome: R-HSA-1169408	"NS1 Mediated Effects on Host Pathways";"ISG15 antiviral mechanism"
XP_046418787.1	2	Reactome: R-HSA-983168;Reactome: R-HSA-6798695	"Antigen processing: Ubiquitination & Proteasome degradation";"Neutrophil degranulation"
XP_046414618.1	1	Reactome: R-HSA-1660661	"Sphingolipid de novo biosynthesis"
XP_046431123.1	2	Reactome: R-HSA-445355;Reactome: R-HSA-390522	"Smooth Muscle Contraction";"Striated Muscle Contraction"
XP_046426255.1	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
XP_046411479.1	5	KEGG: 00760+2.7.1.23;MetaCyc: PWY-7269;MetaCyc: PWY-5083;MetaCyc: PWY-7268;Reactome: R-HSA-196807	"Nicotinate and nicotinamide metabolism";"NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)";"NAD/NADH phosphorylation and dephosphorylation";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"Nicotinate metabolism"
XP_046415499.1	3	Reactome: R-HSA-6804757;Reactome: R-HSA-9609690;Reactome: R-HSA-3899300	"Regulation of TP53 Degradation";"HCMV Early Events";"SUMOylation of transcription cofactors"
XP_046425106.1	2	Reactome: R-HSA-376176;Reactome: R-HSA-202433	"Signaling by ROBO receptors";"Generation of second messenger molecules"
XP_046417308.1	12	MetaCyc: PWY-2821;KEGG: 00450+4.4.1.13;KEGG: 00380+2.6.1.7;MetaCyc: PWY-6936;MetaCyc: PWY-1187;MetaCyc: PWY-6842;KEGG: 00270+4.4.1.13;MetaCyc: PWY-6309;MetaCyc: PWY-7901;Reactome: R-HSA-71240;MetaCyc: PWY-801;MetaCyc: PWY-601	"Glucosinolate biosynthesis from phenylalanine";"Selenocompound metabolism";"Tryptophan metabolism";"Seleno-amino acid biosynthesis (plants)";"Glucosinolate biosynthesis from homomethionine";"Glutathione-mediated detoxification II";"Cysteine and methionine metabolism";"L-tryptophan degradation XI (mammalian, via kynurenine)";"Glucosinolate biosynthesis from tyrosine";"Tryptophan catabolism";"Homocysteine and cysteine interconversion";"Glucosinolate biosynthesis from tryptophan"
XP_046429434.1	1	Reactome: R-HSA-1632852	"Macroautophagy"
XP_046410972.1	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
XP_046431166.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_046435747.1	2	Reactome: R-HSA-380095;Reactome: R-HSA-416476	"Tachykinin receptors bind tachykinins";"G alpha (q) signalling events"
XP_046426252.1	1	Reactome: R-HSA-71288	"Creatine metabolism"
XP_046418293.1	6	Reactome: R-HSA-72163;Reactome: R-HSA-6782210;Reactome: R-HSA-6781823;Reactome: R-HSA-6782135;Reactome: R-HSA-6781827;MetaCyc: PWY-7511	"mRNA Splicing - Major Pathway";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Formation of TC-NER Pre-Incision Complex";"Dual incision in TC-NER";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Protein ubiquitination"
XP_046432443.1	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
XP_046420720.1	14	MetaCyc: PWY-7619;MetaCyc: PWY-7725;MetaCyc: PWY-5080;MetaCyc: PWY-7601;KEGG: 00062+2.3.1.199;MetaCyc: PWY-8041;MetaCyc: PWY-7602;MetaCyc: PWY-6598;MetaCyc: PWY-7036;MetaCyc: PWY-7035;MetaCyc: PWY-6433;MetaCyc: PWY-7724;MetaCyc: PWY-5972;Reactome: R-HSA-75876	"Juniperonate biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Very long chain fatty acid biosynthesis I";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Fatty acid elongation";"Ultra-long-chain fatty acid biosynthesis";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Sciadonate biosynthesis";"Very long chain fatty acid biosynthesis II";"(9Z)-tricosene biosynthesis";"Hydroxylated fatty acid biosynthesis (plants)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Stearate biosynthesis I (animals)";"Synthesis of very long-chain fatty acyl-CoAs"
XP_046431774.1	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840	"Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation"
XP_046427902.1	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276	"Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination"
XP_046422175.1	2	Reactome: R-HSA-379716;KEGG: 00970+6.1.1.21	"Cytosolic tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis"
XP_046413380.1	3	Reactome: R-HSA-73843;KEGG: 00230+2.7.6.1;KEGG: 00030+2.7.6.1	"5-Phosphoribose 1-diphosphate biosynthesis";"Purine metabolism";"Pentose phosphate pathway"
XP_046424412.1	3	Reactome: R-HSA-430039;Reactome: R-HSA-450513;Reactome: R-HSA-450385	"mRNA decay by 5' to 3' exoribonuclease";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA"
XP_046421747.1	2	MetaCyc: PWY-7800;MetaCyc: PWY-7799	"Ac/N-end rule pathway";"Arg/N-end rule pathway (eukaryotic)"
XP_046411617.1	5	KEGG: 00520+2.7.1.6;KEGG: 00052+2.7.1.6;MetaCyc: PWY-6527;MetaCyc: PWY-6317;MetaCyc: PWY-3821	"Amino sugar and nucleotide sugar metabolism";"Galactose metabolism";"Stachyose degradation";"D-galactose degradation I (Leloir pathway)";"D-galactose detoxification"
XP_046429390.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_046429370.1	7	KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1	"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Relaxin signaling pathway";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Human cytomegalovirus infection";"Thermogenesis"
XP_046420823.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046423765.1	4	Reactome: R-HSA-381771;Reactome: R-HSA-400511;Reactome: R-HSA-1799339;Reactome: R-HSA-422085	"Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)";"Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)";"SRP-dependent cotranslational protein targeting to membrane";"Synthesis, secretion, and deacylation of Ghrelin"
XP_046411176.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_046412493.1	4	Reactome: R-HSA-6798163;KEGG: 00260+1.2.1.8+1.1.99.1;MetaCyc: PWY-3722;MetaCyc: PWY-7494	"Choline catabolism";"Glycine, serine and threonine metabolism";"Glycine betaine biosynthesis II (Gram-positive bacteria)";"Choline degradation IV"
XP_046433942.1	5	Reactome: R-HSA-6781827;Reactome: R-HSA-6782135;Reactome: R-HSA-6781823;Reactome: R-HSA-6782210;Reactome: R-HSA-72163	"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Dual incision in TC-NER";"Formation of TC-NER Pre-Incision Complex";"Gap-filling DNA repair synthesis and ligation in TC-NER";"mRNA Splicing - Major Pathway"
XP_046411542.1	16	Reactome: R-HSA-72695;Reactome: R-HSA-1799339;Reactome: R-HSA-72689;Reactome: R-HSA-192823;Reactome: R-HSA-156902;Reactome: R-HSA-72764;Reactome: R-HSA-72649;Reactome: R-HSA-975957;Reactome: R-HSA-2408557;Reactome: R-HSA-72706;Reactome: R-HSA-9633012;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-72702;Reactome: R-HSA-975956;Reactome: R-HSA-6791226	"Formation of the ternary complex, and subsequently, the 43S complex";"SRP-dependent cotranslational protein targeting to membrane";"Formation of a pool of free 40S subunits";"Viral mRNA Translation";"Peptide chain elongation";"Eukaryotic Translation Termination";"Translation initiation complex formation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Selenocysteine synthesis";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Ribosomal scanning and start codon recognition";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046422873.1	1	Reactome: R-HSA-6794361	"Neurexins and neuroligins"
XP_046432471.1	6	Reactome: R-HSA-400253;KEGG: 04660+3.1.3.16;Reactome: R-HSA-2173788;KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16;Reactome: R-HSA-163560	"Circadian Clock";"T cell receptor signaling pathway";"Downregulation of TGF-beta receptor signaling";"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Triglyceride catabolism"
XP_046421039.1	2	Reactome: R-HSA-3295583;Reactome: R-HSA-418890	"TRP channels";"Role of second messengers in netrin-1 signaling"
XP_046427069.1	1	Reactome: R-HSA-6803204	"TP53 Regulates Transcription of Genes Involved in Cytochrome C Release"
XP_046420276.1	15	Reactome: R-HSA-5467333;Reactome: R-HSA-5358751;Reactome: R-HSA-5358752;Reactome: R-HSA-195253;Reactome: R-HSA-5358747;Reactome: R-HSA-4641262;Reactome: R-HSA-111465;Reactome: R-HSA-5339716;Reactome: R-HSA-5467340;Reactome: R-HSA-3769402;Reactome: R-HSA-5689896;Reactome: R-HSA-5358749;Reactome: R-HSA-196299;Reactome: R-HSA-5467337;Reactome: R-HSA-5467348	"APC truncation mutants are not K63 polyubiquitinated";"S45 mutants of beta-catenin aren't phosphorylated";"T41 mutants of beta-catenin aren't phosphorylated";"Degradation of beta-catenin by the destruction complex";"S33 mutants of beta-catenin aren't phosphorylated";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"Apoptotic cleavage of cellular proteins";"Misspliced GSK3beta mutants stabilize beta-catenin";"AXIN missense mutants destabilize the destruction complex";"Deactivation of the beta-catenin transactivating complex";"Ovarian tumor domain proteases";"S37 mutants of beta-catenin aren't phosphorylated";"Beta-catenin phosphorylation cascade";"APC truncation mutants have impaired AXIN binding";"Truncations of AMER1 destabilize the destruction complex"
XP_046412677.1	7	Reactome: R-HSA-5620912;Reactome: R-HSA-380284;Reactome: R-HSA-380320;Reactome: R-HSA-2565942;Reactome: R-HSA-380270;Reactome: R-HSA-8854518;Reactome: R-HSA-380259	"Anchoring of the basal body to the plasma membrane";"Loss of proteins required for interphase microtubule organization from the centrosome";"Recruitment of NuMA to mitotic centrosomes";"Regulation of PLK1 Activity at G2/M Transition";"Recruitment of mitotic centrosome proteins and complexes";"AURKA Activation by TPX2";"Loss of Nlp from mitotic centrosomes"
XP_046430926.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_046411518.1	1	Reactome: R-HSA-6804759	"Regulation of TP53 Activity through Association with Co-factors"
XP_046412153.1	1	Reactome: R-HSA-6814848	"Glycerophospholipid catabolism"
XP_046430456.1	1	Reactome: R-HSA-1483191	"Synthesis of PC"
XP_046430595.1	24	Reactome: R-HSA-9634635;KEGG: 05170+2.7.11.1;Reactome: R-HSA-5218921;KEGG: 04714+2.7.11.1;Reactome: R-HSA-444257;KEGG: 04151+2.7.11.1;Reactome: R-HSA-114604;KEGG: 04150+2.7.11.1;KEGG: 04926+2.7.11.1;Reactome: R-HSA-5625740;Reactome: R-HSA-2730905;Reactome: R-HSA-389357;Reactome: R-HSA-2871837;KEGG: 05163+2.7.11.1;Reactome: R-HSA-392451;Reactome: R-HSA-1257604;Reactome: R-HSA-6804757;Reactome: R-HSA-5674400;Reactome: R-HSA-165158;Reactome: R-HSA-5218920;KEGG: 05165+2.7.11.1;Reactome: R-HSA-202424;Reactome: R-HSA-5607764;Reactome: R-HSA-354192	"Estrogen-stimulated signaling through PRKCZ";"Human immunodeficiency virus 1 infection";"VEGFR2 mediated cell proliferation";"Thermogenesis";"RSK activation";"PI3K-Akt signaling pathway";"GPVI-mediated activation cascade";"mTOR signaling pathway";"Relaxin signaling pathway";"RHO GTPases activate PKNs";"Role of LAT2/NTAL/LAB on calcium mobilization";"CD28 dependent PI3K/Akt signaling";"FCERI mediated NF-kB activation";"Human cytomegalovirus infection";"G beta:gamma signalling through PI3Kgamma";"PIP3 activates AKT signaling";"Regulation of TP53 Degradation";"Constitutive Signaling by AKT1 E17K in Cancer";"Activation of AKT2";"VEGFR2 mediated vascular permeability";"Human papillomavirus infection";"Downstream TCR signaling";"CLEC7A (Dectin-1) signaling";"Integrin signaling"
XP_046431174.1	1	Reactome: R-HSA-6811434	"COPI-dependent Golgi-to-ER retrograde traffic"
XP_046418118.1	6	MetaCyc: PWY-6807;KEGG: 00604+3.2.1.23;KEGG: 00052+3.2.1.23;KEGG: 00531+3.2.1.23;KEGG: 00600+3.2.1.23;KEGG: 00511+3.2.1.23	"Xyloglucan degradation II (exoglucanase)";"Glycosphingolipid biosynthesis - ganglio series";"Galactose metabolism";"Glycosaminoglycan degradation";"Sphingolipid metabolism";"Other glycan degradation"
XP_046411907.1	2	Reactome: R-HSA-3214847;Reactome: R-HSA-427413	"HATs acetylate histones";"NoRC negatively regulates rRNA expression"
XP_046422856.1	1	Reactome: R-HSA-426048	"Arachidonate production from DAG"
XP_046423152.1	6	Reactome: R-HSA-6804756;Reactome: R-HSA-69473;Reactome: R-HSA-5685938;Reactome: R-HSA-5693607;Reactome: R-HSA-5693616;Reactome: R-HSA-176187	"Regulation of TP53 Activity through Phosphorylation";"G2/M DNA damage checkpoint";"HDR through Single Strand Annealing (SSA)";"Processing of DNA double-strand break ends";"Presynaptic phase of homologous DNA pairing and strand exchange";"Activation of ATR in response to replication stress"
XP_046409580.1	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
XP_046417361.1	42	Reactome: R-HSA-5334118;Reactome: R-HSA-427359;Reactome: R-HSA-2559586;Reactome: R-HSA-110330;Reactome: R-HSA-912446;Reactome: R-HSA-977225;Reactome: R-HSA-5578749;Reactome: R-HSA-201722;Reactome: R-HSA-1221632;Reactome: R-HSA-5617472;Reactome: R-HSA-5625886;Reactome: R-HSA-73728;Reactome: R-HSA-9609690;Reactome: R-HSA-2559582;Reactome: R-HSA-69473;Reactome: R-HSA-9018519;Reactome: R-HSA-5693571;Reactome: R-HSA-110328;Reactome: R-HSA-110331;Reactome: R-HSA-427413;Reactome: R-HSA-2559580;Reactome: R-HSA-5693607;Reactome: R-HSA-3214858;Reactome: R-HSA-427389;Reactome: R-HSA-5250924;Reactome: R-HSA-3214847;Reactome: R-HSA-8939236;Reactome: R-HSA-606279;Reactome: R-HSA-3214842;Reactome: R-HSA-9616222;Reactome: R-HSA-3214815;Reactome: R-HSA-212300;Reactome: R-HSA-4551638;Reactome: R-HSA-3214841;Reactome: R-HSA-5693565;Reactome: R-HSA-171306;Reactome: R-HSA-73772;Reactome: R-HSA-8936459;Reactome: R-HSA-1912408;Reactome: R-HSA-2299718;Reactome: R-HSA-9610379;Reactome: R-HSA-110329	"DNA methylation";"SIRT1 negatively regulates rRNA expression";"DNA Damage/Telomere Stress Induced Senescence";"Recognition and association of DNA glycosylase with site containing an affected purine";"Meiotic recombination";"Amyloid fiber formation";"Transcriptional regulation by small RNAs";"Formation of the beta-catenin:TCF transactivating complex";"Meiotic synapsis";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3";"RNA Polymerase I Promoter Opening";"HCMV Early Events";"Senescence-Associated Secretory Phenotype (SASP)";"G2/M DNA damage checkpoint";"Estrogen-dependent gene expression";"Nonhomologous End-Joining (NHEJ)";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"Cleavage of the damaged purine";"NoRC negatively regulates rRNA expression";"Oxidative Stress Induced Senescence";"Processing of DNA double-strand break ends";"RMTs methylate histone arginines";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"B-WICH complex positively regulates rRNA expression";"HATs acetylate histones";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Deposition of new CENPA-containing nucleosomes at the centromere";"HDMs demethylate histones";"Transcriptional regulation of granulopoiesis";"HDACs deacetylate histones";"PRC2 methylates histones and DNA";"SUMOylation of chromatin organization proteins";"PKMTs methylate histone lysines";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Packaging Of Telomere Ends";"RNA Polymerase I Promoter Escape";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Pre-NOTCH Transcription and Translation";"Condensation of Prophase Chromosomes";"HCMV Late Events";"Cleavage of the damaged pyrimidine"
XP_046432137.1	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
XP_046429694.1	1	Reactome: R-HSA-388844	"Receptor-type tyrosine-protein phosphatases"
XP_046426908.1	1	Reactome: R-HSA-5620922	"BBSome-mediated cargo-targeting to cilium"
XP_046417526.1	24	Reactome: R-HSA-5626467;Reactome: R-HSA-6807878;Reactome: R-HSA-9619483;Reactome: R-HSA-1445148;Reactome: R-HSA-983189;Reactome: R-HSA-2500257;Reactome: R-HSA-9648025;Reactome: R-HSA-380320;Reactome: R-HSA-9609690;Reactome: R-HSA-2467813;Reactome: R-HSA-6811434;Reactome: R-HSA-3371497;Reactome: R-HSA-5663220;Reactome: R-HSA-437239;Reactome: R-HSA-8955332;Reactome: R-HSA-9609736;Reactome: R-HSA-8852276;Reactome: R-HSA-68877;Reactome: R-HSA-190840;Reactome: R-HSA-190861;Reactome: R-HSA-9646399;Reactome: R-HSA-6811436;Reactome: R-HSA-5617833;Reactome: R-HSA-2132295	"RHO GTPases activate IQGAPs";"COPI-mediated anterograde transport";"Activation of AMPK downstream of NMDARs";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Kinesins";"Resolution of Sister Chromatid Cohesion";"EML4 and NUDC in mitotic spindle formation";"Recruitment of NuMA to mitotic centrosomes";"HCMV Early Events";"Separation of Sister Chromatids";"COPI-dependent Golgi-to-ER retrograde traffic";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"RHO GTPases Activate Formins";"Recycling pathway of L1";"Carboxyterminal post-translational modifications of tubulin";"Assembly and cell surface presentation of NMDA receptors";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Mitotic Prometaphase";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Gap junction assembly";"Aggrephagy";"COPI-independent Golgi-to-ER retrograde traffic";"Cilium Assembly";"MHC class II antigen presentation"
XP_046409867.1	1	Reactome: R-HSA-6783984	"Glycine degradation"
XP_046432840.1	3	Reactome: R-HSA-72187;Reactome: R-HSA-159236;Reactome: R-HSA-73856	"mRNA 3'-end processing";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"RNA Polymerase II Transcription Termination"
XP_046420660.1	5	Reactome: R-HSA-1222556;Reactome: R-HSA-77387;Reactome: R-HSA-9639288;Reactome: R-HSA-917977;Reactome: R-HSA-983712	"ROS and RNS production in phagocytes";"Insulin receptor recycling";"Amino acids regulate mTORC1";"Transferrin endocytosis and recycling";"Ion channel transport"
XP_046422763.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_046433408.1	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
XP_046431998.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_046412931.1	1	Reactome: R-HSA-1483166	"Synthesis of PA"
XP_046418918.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_046435877.1	3	Reactome: R-HSA-6807878;Reactome: R-HSA-8963901;Reactome: R-HSA-445095	"COPI-mediated anterograde transport";"Chylomicron remodeling";"Interaction between L1 and Ankyrins"
XP_046427975.1	14	Reactome: R-HSA-9022692;Reactome: R-HSA-203927;Reactome: R-HSA-5687128;Reactome: R-HSA-426496;Reactome: R-HSA-9029569;Reactome: R-HSA-8934593;Reactome: R-HSA-9018519;Reactome: R-HSA-426486;Reactome: R-HSA-1912408;Reactome: R-HSA-8943723;Reactome: R-HSA-8986944;Reactome: R-HSA-4086398;Reactome: R-HSA-5628897;Reactome: R-HSA-8948700	"Regulation of MECP2 expression and activity";"MicroRNA (miRNA) biogenesis";"MAPK6/MAPK4 signaling";"Post-transcriptional silencing by small RNAs";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Regulation of RUNX1 Expression and Activity";"Estrogen-dependent gene expression";"Small interfering RNA (siRNA) biogenesis";"Pre-NOTCH Transcription and Translation";"Regulation of PTEN mRNA translation";"Transcriptional Regulation by MECP2";"Ca2+ pathway";"TP53 Regulates Metabolic Genes";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation"
XP_046413549.1	7	Reactome: R-HSA-2979096;MetaCyc: PWY-7511;Reactome: R-HSA-2691232;Reactome: R-HSA-2894862;Reactome: R-HSA-2122948;Reactome: R-HSA-9013507;Reactome: R-HSA-2644606	"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Protein ubiquitination";"Constitutive Signaling by NOTCH1 HD Domain Mutants";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Activated NOTCH1 Transmits Signal to the Nucleus";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Constitutive Signaling by NOTCH1 PEST Domain Mutants"
XP_046420080.1	16	Reactome: R-HSA-2408557;Reactome: R-HSA-72706;Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-72702;Reactome: R-HSA-6791226;Reactome: R-HSA-72695;Reactome: R-HSA-1799339;Reactome: R-HSA-72689;Reactome: R-HSA-192823;Reactome: R-HSA-156902;Reactome: R-HSA-72764;Reactome: R-HSA-72649;Reactome: R-HSA-975957	"Selenocysteine synthesis";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Ribosomal scanning and start codon recognition";"Major pathway of rRNA processing in the nucleolus and cytosol";"Formation of the ternary complex, and subsequently, the 43S complex";"SRP-dependent cotranslational protein targeting to membrane";"Formation of a pool of free 40S subunits";"Viral mRNA Translation";"Peptide chain elongation";"Eukaryotic Translation Termination";"Translation initiation complex formation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
XP_046411343.1	5	MetaCyc: PWY-7269;KEGG: 00760+2.7.1.23;MetaCyc: PWY-5083;Reactome: R-HSA-196807;MetaCyc: PWY-7268	"NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)";"Nicotinate and nicotinamide metabolism";"NAD/NADH phosphorylation and dephosphorylation";"Nicotinate metabolism";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)"
XP_046416155.1	1	Reactome: R-HSA-70221	"Glycogen breakdown (glycogenolysis)"
XP_046435902.1	2	Reactome: R-HSA-445095;Reactome: R-HSA-6807878	"Interaction between L1 and Ankyrins";"COPI-mediated anterograde transport"
XP_046435895.1	3	Reactome: R-HSA-8963901;Reactome: R-HSA-6807878;Reactome: R-HSA-445095	"Chylomicron remodeling";"COPI-mediated anterograde transport";"Interaction between L1 and Ankyrins"
XP_046432613.1	3	KEGG: 00510+2.4.1.117;Reactome: R-HSA-480985;Reactome: R-HSA-913709	"N-Glycan biosynthesis";"Synthesis of dolichyl-phosphate-glucose";"O-linked glycosylation of mucins"
XP_046413428.1	11	Reactome: R-HSA-6785631;Reactome: R-HSA-2219530;Reactome: R-HSA-9664565;Reactome: R-HSA-8847993;Reactome: R-HSA-1257604;Reactome: R-HSA-5673001;Reactome: R-HSA-1227986;Reactome: R-HSA-1250196;Reactome: R-HSA-1963642;Reactome: R-HSA-8863795;Reactome: R-HSA-6811558	"ERBB2 Regulates Cell Motility";"Constitutive Signaling by Aberrant PI3K in Cancer";"Signaling by ERBB2 KD Mutants";"ERBB2 Activates PTK6 Signaling";"PIP3 activates AKT signaling";"RAF/MAP kinase cascade";"Signaling by ERBB2";"SHC1 events in ERBB2 signaling";"PI3K events in ERBB2 signaling";"Downregulation of ERBB2 signaling";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"
XP_046421523.1	3	Reactome: R-HSA-192456;MetaCyc: PWY-6857;KEGG: 00561+3.1.1.3	"Digestion of dietary lipid";"Retinol biosynthesis";"Glycerolipid metabolism"
XP_046414771.1	8	Reactome: R-HSA-8866652;Reactome: R-HSA-6782135;Reactome: R-HSA-8948747;Reactome: R-HSA-6781827;Reactome: R-HSA-6782210;Reactome: R-HSA-5689880;Reactome: R-HSA-6781823;Reactome: R-HSA-6804757	"Synthesis of active ubiquitin: roles of E1 and E2 enzymes";"Dual incision in TC-NER";"Regulation of PTEN localization";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Ub-specific processing proteases";"Formation of TC-NER Pre-Incision Complex";"Regulation of TP53 Degradation"
XP_046434696.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_046411288.1	2	Reactome: R-HSA-167826;Reactome: R-HSA-167827	"The fatty acid cycling model";"The proton buffering model"
XP_046413191.1	8	KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;Reactome: R-HSA-975957;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1	"Thermogenesis";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Human cytomegalovirus infection";"Relaxin signaling pathway"
XP_046432799.1	3	Reactome: R-HSA-8951664;MetaCyc: PWY-7511;Reactome: R-HSA-349425	"Neddylation";"Protein ubiquitination";"Autodegradation of the E3 ubiquitin ligase COP1"
XP_046420518.1	1	Reactome: R-HSA-426117	"Cation-coupled Chloride cotransporters"
XP_046425750.1	2	Reactome: R-HSA-2682334;Reactome: R-HSA-3928665	"EPH-Ephrin signaling";"EPH-ephrin mediated repulsion of cells"
XP_046419987.1	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
XP_046417470.1	30	Reactome: R-HSA-5610780;Reactome: R-HSA-5607761;Reactome: R-HSA-69231;Reactome: R-HSA-983168;Reactome: R-HSA-9604323;Reactome: R-HSA-5676590;Reactome: R-HSA-8939902;Reactome: R-HSA-1169091;Reactome: R-HSA-400253;Reactome: R-HSA-2894862;Reactome: R-HSA-68949;Reactome: R-HSA-2871837;Reactome: R-HSA-195253;Reactome: R-HSA-8951664;Reactome: R-HSA-917937;Reactome: R-HSA-8854050;Reactome: R-HSA-9020702;Reactome: R-HSA-174113;Reactome: R-HSA-2122947;Reactome: R-HSA-2644606;Reactome: R-HSA-202424;Reactome: R-HSA-5607764;Reactome: R-HSA-5610785;Reactome: R-HSA-1170546;Reactome: R-HSA-187577;Reactome: R-HSA-180534;Reactome: R-HSA-5684264;Reactome: R-HSA-2565942;Reactome: R-HSA-2644607;Reactome: R-HSA-5610783	"Degradation of GLI1 by the proteasome";"Dectin-1 mediated noncanonical NF-kB signaling";"Cyclin D associated events in G1";"Antigen processing: Ubiquitination & Proteasome degradation";"Negative regulation of NOTCH4 signaling";"NIK-->noncanonical NF-kB signaling";"Regulation of RUNX2 expression and activity";"Activation of NF-kappaB in B cells";"Circadian Clock";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Orc1 removal from chromatin";"FCERI mediated NF-kB activation";"Degradation of beta-catenin by the destruction complex";"Neddylation";"Iron uptake and transport";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Interleukin-1 signaling";"SCF-beta-TrCP mediated degradation of Emi1";"NOTCH1 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Downstream TCR signaling";"CLEC7A (Dectin-1) signaling";"GLI3 is processed to GLI3R by the proteasome";"Prolactin receptor signaling";"SCF(Skp2)-mediated degradation of p27/p21";"Vpu mediated degradation of CD4";"MAP3K8 (TPL2)-dependent MAPK1/3 activation";"Regulation of PLK1 Activity at G2/M Transition";"Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling";"Degradation of GLI2 by the proteasome"
XP_046433841.1	1	Reactome: R-HSA-1474228	"Degradation of the extracellular matrix"
XP_046429497.1	5	Reactome: R-HSA-5687128;KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16;Reactome: R-HSA-176407	"MAPK6/MAPK4 signaling";"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase"
XP_046411262.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046410807.1	2	Reactome: R-HSA-1483148;Reactome: R-HSA-1483166	"Synthesis of PG";"Synthesis of PA"
XP_046432541.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046418786.1	2	Reactome: R-HSA-983168;Reactome: R-HSA-6798695	"Antigen processing: Ubiquitination & Proteasome degradation";"Neutrophil degranulation"
XP_046436609.1	1	Reactome: R-HSA-6799198	"Complex I biogenesis"
XP_046419597.1	3	KEGG: 00010+5.1.3.3;KEGG: 00052+5.1.3.3;MetaCyc: PWY-6317	"Glycolysis / Gluconeogenesis";"Galactose metabolism";"D-galactose degradation I (Leloir pathway)"
XP_046431879.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046413242.1	7	KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1	"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Relaxin signaling pathway";"Thermogenesis";"Human cytomegalovirus infection";"mTOR signaling pathway";"PI3K-Akt signaling pathway"
XP_046424615.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046409802.1	11	Reactome: R-HSA-5685938;Reactome: R-HSA-2029482;Reactome: R-HSA-8939236;Reactome: R-HSA-5663213;Reactome: R-HSA-428890;Reactome: R-HSA-983231;Reactome: R-HSA-8940973;Reactome: R-HSA-69231;Reactome: R-HSA-5693565;KEGG: 04660+2.7.10.2;Reactome: R-HSA-525793	"HDR through Single Strand Annealing (SSA)";"Regulation of actin dynamics for phagocytic cup formation";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"RHO GTPases Activate WASPs and WAVEs";"Role of ABL in ROBO-SLIT signaling";"Factors involved in megakaryocyte development and platelet production";"RUNX2 regulates osteoblast differentiation";"Cyclin D associated events in G1";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"T cell receptor signaling pathway";"Myogenesis"
XP_046410453.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046419611.1	14	MetaCyc: PWY-7417;MetaCyc: PWY-7782;MetaCyc: PWY-7589;MetaCyc: PWY-5981;MetaCyc: PWY-8053;Reactome: R-HSA-1483166;MetaCyc: PWY-7411;MetaCyc: PWY-7587;MetaCyc: PWY-8051;MetaCyc: PWY-6453;KEGG: 00564+2.3.1.51;KEGG: 00561+2.3.1.51;MetaCyc: PWY-8055;MetaCyc: PWY-5667	"Phospholipid remodeling (phosphatidate, yeast)";"Plasmalogen biosynthesis";"Palmitoleate biosynthesis III (cyanobacteria)";"CDP-diacylglycerol biosynthesis III";"Anandamide biosynthesis II";"Synthesis of PA";"Phosphatidate biosynthesis (yeast)";"Oleate biosynthesis III (cyanobacteria)";"Anandamide biosynthesis I";"Stigma estolide biosynthesis";"Glycerophospholipid metabolism";"Glycerolipid metabolism";"Palmitoyl ethanolamide biosynthesis";"CDP-diacylglycerol biosynthesis I"
XP_046434579.1	3	Reactome: R-HSA-418597;KEGG: 04070+2.7.11.13;Reactome: R-HSA-114508	"G alpha (z) signalling events";"Phosphatidylinositol signaling system";"Effects of PIP2 hydrolysis"
XP_046416221.1	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
XP_046429274.1	1	Reactome: R-HSA-8856828	"Clathrin-mediated endocytosis"
XP_046432481.1	15	MetaCyc: PWY-7003;Reactome: R-HSA-70171;MetaCyc: PWY-5484;KEGG: 00230+2.7.1.40;KEGG: 00620+2.7.1.40;MetaCyc: PWY-7383;MetaCyc: PWY-1042;KEGG: 00010+2.7.1.40;MetaCyc: PWY-6142;MetaCyc: PWY-5723;MetaCyc: PWY-8004;MetaCyc: PWY-2221;MetaCyc: PWY-6901;MetaCyc: PWY-7218;MetaCyc: PWY-6886	"Glycerol degradation to butanol";"Glycolysis";"Glycolysis II (from fructose 6-phosphate)";"Purine metabolism";"Pyruvate metabolism";"Anaerobic energy metabolism (invertebrates, cytosol)";"Glycolysis IV (plant cytosol)";"Glycolysis / Gluconeogenesis";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Rubisco shunt";"Entner-Doudoroff pathway I";"Entner-Doudoroff pathway III (semi-phosphorylative)";"Superpathway of glucose and xylose degradation";"Photosynthetic 3-hydroxybutanoate biosynthesis (engineered)";"1-butanol autotrophic biosynthesis (engineered)"
XP_046436312.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_046416801.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046419151.1	2	Reactome: R-HSA-8939243;Reactome: R-HSA-3214858	"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RMTs methylate histone arginines"
XP_046436669.1	12	Reactome: R-HSA-9648025;Reactome: R-HSA-141444;Reactome: R-HSA-9609690;Reactome: R-HSA-68877;Reactome: R-HSA-6811436;Reactome: R-HSA-2467813;Reactome: R-HSA-9646399;Reactome: R-HSA-2132295;Reactome: R-HSA-3371497;Reactome: R-HSA-6807878;Reactome: R-HSA-5663220;Reactome: R-HSA-2500257	"EML4 and NUDC in mitotic spindle formation";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"HCMV Early Events";"Mitotic Prometaphase";"COPI-independent Golgi-to-ER retrograde traffic";"Separation of Sister Chromatids";"Aggrephagy";"MHC class II antigen presentation";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-mediated anterograde transport";"RHO GTPases Activate Formins";"Resolution of Sister Chromatid Cohesion"
XP_046415011.1	7	KEGG: 00471+3.5.1.2;Reactome: R-HSA-8964539;KEGG: 00220+3.5.1.2;Reactome: R-HSA-210500;KEGG: 00250+3.5.1.2;MetaCyc: PWY-5921;Reactome: R-HSA-5628897	"D-Glutamine and D-glutamate metabolism";"Glutamate and glutamine metabolism";"Arginine biosynthesis";"Glutamate Neurotransmitter Release Cycle";"Alanine, aspartate and glutamate metabolism";"Glutaminyl-trnagln biosynthesis via transamidation";"TP53 Regulates Metabolic Genes"
XP_046421978.1	2	Reactome: R-HSA-418457;Reactome: R-HSA-1296052	"cGMP effects";"Ca2+ activated K+ channels"
XP_046419634.1	2	Reactome: R-HSA-983168;Reactome: R-HSA-8951664	"Antigen processing: Ubiquitination & Proteasome degradation";"Neddylation"
XP_046434312.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_046427065.1	3	KEGG: 00680+3.1.3.3;Reactome: R-HSA-977347;KEGG: 00260+3.1.3.3	"Methane metabolism";"Serine biosynthesis";"Glycine, serine and threonine metabolism"
XP_046430617.1	3	Reactome: R-HSA-202427;Reactome: R-HSA-6807004;Reactome: R-HSA-6798695	"Phosphorylation of CD3 and TCR zeta chains";"Negative regulation of MET activity";"Neutrophil degranulation"
XP_046412678.1	7	Reactome: R-HSA-380284;Reactome: R-HSA-5620912;Reactome: R-HSA-2565942;Reactome: R-HSA-380270;Reactome: R-HSA-380320;Reactome: R-HSA-380259;Reactome: R-HSA-8854518	"Loss of proteins required for interphase microtubule organization from the centrosome";"Anchoring of the basal body to the plasma membrane";"Regulation of PLK1 Activity at G2/M Transition";"Recruitment of mitotic centrosome proteins and complexes";"Recruitment of NuMA to mitotic centrosomes";"Loss of Nlp from mitotic centrosomes";"AURKA Activation by TPX2"
XP_046422326.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046434968.1	2	Reactome: R-HSA-375276;Reactome: R-HSA-416476	"Peptide ligand-binding receptors";"G alpha (q) signalling events"
XP_046411896.1	1	Reactome: R-HSA-5221030	"TET1,2,3 and TDG demethylate DNA"
XP_046412989.1	25	Reactome: R-HSA-8941332;Reactome: R-HSA-8931987;Reactome: R-HSA-8941326;Reactome: R-HSA-8939256;Reactome: R-HSA-9616222;Reactome: R-HSA-8941333;Reactome: R-HSA-8939242;Reactome: R-HSA-8951936;Reactome: R-HSA-8941284;Reactome: R-HSA-8939236;Reactome: R-HSA-8934593;Reactome: R-HSA-8877330;Reactome: R-HSA-8949275;Reactome: R-HSA-8939247;Reactome: R-HSA-8935964;Reactome: R-HSA-8940973;Reactome: R-HSA-8878166;Reactome: R-HSA-8951911;Reactome: R-HSA-8939243;Reactome: R-HSA-8941858;Reactome: R-HSA-8939902;Reactome: R-HSA-8939246;Reactome: R-HSA-8936459;Reactome: R-HSA-9018519;Reactome: R-HSA-8939245	"RUNX2 regulates genes involved in cell migration";"RUNX1 regulates estrogen receptor mediated transcription";"RUNX2 regulates bone development";"RUNX1 regulates transcription of genes involved in WNT signaling";"Transcriptional regulation of granulopoiesis";"RUNX2 regulates genes involved in differentiation of myeloid cells";"RUNX1 regulates transcription of genes involved in differentiation of keratinocytes";"RUNX3 regulates p14-ARF";"RUNX2 regulates chondrocyte maturation";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Regulation of RUNX1 Expression and Activity";"RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)";"RUNX3 Regulates Immune Response and Cell Migration";"RUNX1 regulates transcription of genes involved in interleukin signaling";"RUNX1 regulates expression of components of tight junctions";"RUNX2 regulates osteoblast differentiation";"Transcriptional regulation by RUNX2";"RUNX3 regulates RUNX1-mediated transcription";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"Regulation of RUNX3 expression and activity";"Regulation of RUNX2 expression and activity";"RUNX1 regulates transcription of genes involved in differentiation of myeloid cells";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Estrogen-dependent gene expression";"RUNX1 regulates transcription of genes involved in BCR signaling"
XP_046422248.1	3	Reactome: R-HSA-749476;Reactome: R-HSA-76061;Reactome: R-HSA-76066	"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Transcription Initiation From Type 2 Promoter"
XP_046415181.1	2	Reactome: R-HSA-3295583;Reactome: R-HSA-418890	"TRP channels";"Role of second messengers in netrin-1 signaling"
XP_046432977.1	1	Reactome: R-HSA-70221	"Glycogen breakdown (glycogenolysis)"
XP_046417612.1	2	Reactome: R-HSA-375281;Reactome: R-HSA-416476	"Hormone ligand-binding receptors";"G alpha (q) signalling events"
XP_046428574.1	2	Reactome: R-HSA-164843;Reactome: R-HSA-5693571	"2-LTR circle formation";"Nonhomologous End-Joining (NHEJ)"
XP_046434740.1	3	Reactome: R-HSA-418594;Reactome: R-HSA-375276;Reactome: R-HSA-416476	"G alpha (i) signalling events";"Peptide ligand-binding receptors";"G alpha (q) signalling events"
XP_046410274.1	2	Reactome: R-HSA-6804115;Reactome: R-HSA-429947	"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Deadenylation of mRNA"
XP_046419247.1	1	Reactome: R-HSA-352230	"Amino acid transport across the plasma membrane"
XP_046426573.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046427739.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_046425448.1	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286	"Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation"
XP_046416061.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_046434866.1	1	Reactome: R-HSA-1445148	"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
XP_046419680.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_046432827.1	3	Reactome: R-HSA-5576893;Reactome: R-HSA-5576890;Reactome: R-HSA-1296072	"Phase 2 - plateau phase";"Phase 3 - rapid repolarisation";"Voltage gated Potassium channels"
XP_046411620.1	5	MetaCyc: PWY-6527;KEGG: 00052+2.7.1.6;KEGG: 00520+2.7.1.6;MetaCyc: PWY-6317;MetaCyc: PWY-3821	"Stachyose degradation";"Galactose metabolism";"Amino sugar and nucleotide sugar metabolism";"D-galactose degradation I (Leloir pathway)";"D-galactose detoxification"
XP_046422167.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046422974.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-5628897	"Respiratory electron transport";"TP53 Regulates Metabolic Genes"
XP_046410786.1	6	Reactome: R-HSA-6791226;Reactome: R-HSA-450385;Reactome: R-HSA-450604;Reactome: R-HSA-450513;Reactome: R-HSA-380994;Reactome: R-HSA-429958	"Major pathway of rRNA processing in the nucleolus and cytosol";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"KSRP (KHSRP) binds and destabilizes mRNA";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"ATF4 activates genes in response to endoplasmic reticulum stress";"mRNA decay by 3' to 5' exoribonuclease"
XP_046418304.1	1	Reactome: R-HSA-211945	"Phase I - Functionalization of compounds"
XP_046427642.1	1	Reactome: R-HSA-1660661	"Sphingolipid de novo biosynthesis"
XP_046424103.1	4	Reactome: R-HSA-6798695;Reactome: R-HSA-6802952;Reactome: R-HSA-1632852;Reactome: R-HSA-983168	"Neutrophil degranulation";"Signaling by BRAF and RAF fusions";"Macroautophagy";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046419058.1	1	Reactome: R-HSA-196843	"Vitamin B2 (riboflavin) metabolism"
XP_046410498.1	2	Reactome: R-HSA-5682910;Reactome: R-HSA-5250971	"LGI-ADAM interactions";"Toxicity of botulinum toxin type C (BoNT/C)"
XP_046412986.1	25	Reactome: R-HSA-9616222;Reactome: R-HSA-8939242;Reactome: R-HSA-8941333;Reactome: R-HSA-8951936;Reactome: R-HSA-8941284;Reactome: R-HSA-8934593;Reactome: R-HSA-8939236;Reactome: R-HSA-8949275;Reactome: R-HSA-8877330;Reactome: R-HSA-8941332;Reactome: R-HSA-8931987;Reactome: R-HSA-8941326;Reactome: R-HSA-8939256;Reactome: R-HSA-8939902;Reactome: R-HSA-8936459;Reactome: R-HSA-8939246;Reactome: R-HSA-8939245;Reactome: R-HSA-9018519;Reactome: R-HSA-8939247;Reactome: R-HSA-8940973;Reactome: R-HSA-8935964;Reactome: R-HSA-8951911;Reactome: R-HSA-8878166;Reactome: R-HSA-8941858;Reactome: R-HSA-8939243	"Transcriptional regulation of granulopoiesis";"RUNX1 regulates transcription of genes involved in differentiation of keratinocytes";"RUNX2 regulates genes involved in differentiation of myeloid cells";"RUNX3 regulates p14-ARF";"RUNX2 regulates chondrocyte maturation";"Regulation of RUNX1 Expression and Activity";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"RUNX3 Regulates Immune Response and Cell Migration";"RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)";"RUNX2 regulates genes involved in cell migration";"RUNX1 regulates estrogen receptor mediated transcription";"RUNX2 regulates bone development";"RUNX1 regulates transcription of genes involved in WNT signaling";"Regulation of RUNX2 expression and activity";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"RUNX1 regulates transcription of genes involved in differentiation of myeloid cells";"RUNX1 regulates transcription of genes involved in BCR signaling";"Estrogen-dependent gene expression";"RUNX1 regulates transcription of genes involved in interleukin signaling";"RUNX2 regulates osteoblast differentiation";"RUNX1 regulates expression of components of tight junctions";"RUNX3 regulates RUNX1-mediated transcription";"Transcriptional regulation by RUNX2";"Regulation of RUNX3 expression and activity";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"
XP_046424772.1	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
XP_046420548.1	3	Reactome: R-HSA-383280;Reactome: R-HSA-8939236;Reactome: R-HSA-983231	"Nuclear Receptor transcription pathway";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Factors involved in megakaryocyte development and platelet production"
XP_046418325.1	7	Reactome: R-HSA-156711;Reactome: R-HSA-1362300;Reactome: R-HSA-69656;Reactome: R-HSA-69202;Reactome: R-HSA-1538133;Reactome: R-HSA-1362277;Reactome: R-HSA-69205	"Polo-like kinase mediated events";"Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1";"Cyclin A:Cdk2-associated events at S phase entry";"Cyclin E associated events during G1/S transition";"G0 and Early G1";"Transcription of E2F targets under negative control by DREAM complex";"G1/S-Specific Transcription"
XP_046421061.1	4	Reactome: R-HSA-6811434;Reactome: R-HSA-5625970;Reactome: R-HSA-2132295;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"RHO GTPases activate KTN1";"MHC class II antigen presentation";"Kinesins"
XP_046421630.1	3	Reactome: R-HSA-1855167;MetaCyc: PWY-6369;KEGG: 04070+2.7.4.24+2.7.4.21	"Synthesis of pyrophosphates in the cytosol";"Inositol diphosphates biosynthesis";"Phosphatidylinositol signaling system"
XP_046433388.1	3	Reactome: R-HSA-194840;Reactome: R-HSA-416482;Reactome: R-HSA-193648	"Rho GTPase cycle";"G alpha (12/13) signalling events";"NRAGE signals death through JNK"
XP_046413371.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_046418404.1	8	MetaCyc: PWY-6545;MetaCyc: PWY-7210;MetaCyc: PWY-7184;Reactome: R-HSA-499943;MetaCyc: PWY-7187;KEGG: 00240+2.7.4.9;MetaCyc: PWY-7198;MetaCyc: PWY-7197	"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Interconversion of nucleotide di- and triphosphates";"Pyrimidine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Pyrimidine deoxyribonucleotide phosphorylation"
XP_046420807.1	5	Reactome: R-HSA-9648895;Reactome: R-HSA-380994;Reactome: R-HSA-9633012;Reactome: R-HSA-8963693;KEGG: 00250+6.3.5.4	"Response of EIF2AK1 (HRI) to heme deficiency";"ATF4 activates genes in response to endoplasmic reticulum stress";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Aspartate and asparagine metabolism";"Alanine, aspartate and glutamate metabolism"
XP_046419179.1	2	Reactome: R-HSA-390471;Reactome: R-HSA-1660662	"Association of TriC/CCT with target proteins during biosynthesis";"Glycosphingolipid metabolism"
XP_046424684.1	5	MetaCyc: PWY-7921;KEGG: 00514+2.4.1.109;MetaCyc: PWY-7979;KEGG: 00515+2.4.1.109;MetaCyc: PWY-7922	"Protein O-mannosylation I (yeast)";"Other types of O-glycan biosynthesis";"Protein O-mannosylation III (mammals, core M3)";"Mannose type O-glycan biosynthesis";"Protein O-mannosylation II (mammals, core M1 and core M2)"
XP_046423813.1	10	KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;Reactome: R-HSA-3214847;Reactome: R-HSA-201722;Reactome: R-HSA-5689880;KEGG: 04714+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1	"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Human cytomegalovirus infection";"Relaxin signaling pathway";"HATs acetylate histones";"Formation of the beta-catenin:TCF transactivating complex";"Ub-specific processing proteases";"Thermogenesis";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection"
XP_046431885.1	6	Reactome: R-HSA-8876198;Reactome: R-HSA-9615710;Reactome: R-HSA-174490;Reactome: R-HSA-917729;Reactome: R-HSA-162588;Reactome: R-HSA-9610379	"RAB GEFs exchange GTP for GDP on RABs";"Late endosomal microautophagy";"Membrane binding and targetting of GAG proteins";"Endosomal Sorting Complex Required For Transport (ESCRT)";"Budding and maturation of HIV virion";"HCMV Late Events"
XP_046425126.1	1	Reactome: R-HSA-975957	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
XP_046420500.1	1	Reactome: R-HSA-428359	"Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA"
XP_046419521.1	3	Reactome: R-HSA-3000157;Reactome: R-HSA-3000171;Reactome: R-HSA-8874081	"Laminin interactions";"Non-integrin membrane-ECM interactions";"MET activates PTK2 signaling"
XP_046412050.1	3	Reactome: R-HSA-6811434;Reactome: R-HSA-983189;Reactome: R-HSA-390471	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins";"Association of TriC/CCT with target proteins during biosynthesis"
XP_046416977.1	1	Reactome: R-HSA-6794361	"Neurexins and neuroligins"
XP_046423529.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046412915.1	4	KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16;Reactome: R-HSA-6807505;KEGG: 05235+3.1.3.16	"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation";"RNA polymerase II transcribes snRNA genes";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
XP_046418403.1	1	Reactome: R-HSA-204005	"COPII-mediated vesicle transport"
XP_046416860.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_046414642.1	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
XP_046435714.1	2	Reactome: R-HSA-2142753;KEGG: 00970+6.3.5.7	"Arachidonic acid metabolism";"Aminoacyl-tRNA biosynthesis"
XP_046412145.1	1	Reactome: R-HSA-9616222	"Transcriptional regulation of granulopoiesis"
XP_046411207.1	5	Reactome: R-HSA-77387;Reactome: R-HSA-1222556;Reactome: R-HSA-917977;Reactome: R-HSA-9639288;Reactome: R-HSA-983712	"Insulin receptor recycling";"ROS and RNS production in phagocytes";"Transferrin endocytosis and recycling";"Amino acids regulate mTORC1";"Ion channel transport"
XP_046414206.1	2	KEGG: 00510+2.4.1.142;KEGG: 00513+2.4.1.142	"N-Glycan biosynthesis";"Various types of N-glycan biosynthesis"
XP_046414394.1	2	Reactome: R-HSA-9634600;KEGG: 00051+2.7.1.105+3.1.3.46	"Regulation of glycolysis by fructose 2,6-bisphosphate metabolism";"Fructose and mannose metabolism"
XP_046414509.1	2	Reactome: R-HSA-1483115;Reactome: R-HSA-1483152	"Hydrolysis of LPC";"Hydrolysis of LPE"
XP_046435268.1	3	KEGG: 00740+3.1.3.2;MetaCyc: PWY-6348;KEGG: 00730+3.1.3.2	"Riboflavin metabolism";"Phosphate acquisition";"Thiamine metabolism"
XP_046419721.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046424601.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046418310.1	1	Reactome: R-HSA-1855231	"Synthesis of IPs in the ER lumen"
XP_046435370.1	2	Reactome: R-HSA-8856828;Reactome: R-HSA-8856825	"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis"
XP_046432690.1	2	Reactome: R-HSA-445095;Reactome: R-HSA-5576892	"Interaction between L1 and Ankyrins";"Phase 0 - rapid depolarisation"
XP_046436627.1	1	Reactome: R-HSA-5601884	"PIWI-interacting RNA (piRNA) biogenesis"
XP_046411298.1	2	Reactome: R-HSA-8949215;Reactome: R-HSA-5689880	"Mitochondrial calcium ion transport";"Ub-specific processing proteases"
XP_046426359.1	8	Reactome: R-HSA-5683826;MetaCyc: PWY-7179-1;Reactome: R-HSA-74217;MetaCyc: PWY-7179;Reactome: R-HSA-6798695;MetaCyc: PWY-6611;MetaCyc: PWY-6609;KEGG: 00230+3.5.4.4	"Surfactant metabolism";"Purine deoxyribonucleosides degradation II";"Purine salvage";"Purine deoxyribonucleosides degradation I";"Neutrophil degranulation";"Adenine and adenosine salvage V";"Adenine and adenosine salvage III";"Purine metabolism"
XP_046410247.1	1	Reactome: R-HSA-975957	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
XP_046429256.1	11	MetaCyc: PWY-6549;MetaCyc: PWY-7268;KEGG: 00720+1.1.1.42;Reactome: R-HSA-71403;KEGG: 00480+1.1.1.42;MetaCyc: PWY-5913;MetaCyc: PWY-7124;MetaCyc: PWY-6728;KEGG: 00020+1.1.1.42;MetaCyc: PWY-6969;MetaCyc: PWY-7254	"L-glutamine biosynthesis III";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"Carbon fixation pathways in prokaryotes";"Citric acid cycle (TCA cycle)";"Glutathione metabolism";"Partial TCA cycle (obligate autotrophs)";"Ethylene biosynthesis V (engineered)";"Methylaspartate cycle";"Citrate cycle (TCA cycle)";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"TCA cycle VII (acetate-producers)"
XP_046409361.1	3	Reactome: R-HSA-74259;Reactome: R-HSA-196807;Reactome: R-HSA-73621	"Purine catabolism";"Nicotinate metabolism";"Pyrimidine catabolism"
XP_046433184.1	1	Reactome: R-HSA-2022377	"Metabolism of Angiotensinogen to Angiotensins"
XP_046429299.1	1	Reactome: R-HSA-400253	"Circadian Clock"
XP_046410883.1	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840	"Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation"
XP_046420198.1	1	Reactome: R-HSA-159236	"Transport of Mature mRNA derived from an Intron-Containing Transcript"
XP_046411089.1	3	Reactome: R-HSA-9018519;Reactome: R-HSA-1989781;Reactome: R-HSA-381340	"Estrogen-dependent gene expression";"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation"
XP_046415762.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046413653.1	2	Reactome: R-HSA-8856825;Reactome: R-HSA-8856828	"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis"
XP_046424517.1	1	Reactome: R-HSA-156842	"Eukaryotic Translation Elongation"
XP_046426559.1	1	Reactome: R-HSA-912446	"Meiotic recombination"
XP_046426621.1	4	MetaCyc: PWY-8004;KEGG: 00030+1.1.1.49;MetaCyc: PWY-7268;KEGG: 00480+1.1.1.49	"Entner-Doudoroff pathway I";"Pentose phosphate pathway";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"Glutathione metabolism"
XP_046432713.1	2	Reactome: R-HSA-8862803;Reactome: R-HSA-69273	"Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models";"Cyclin A/B1/B2 associated events during G2/M transition"
XP_046426586.1	2	MetaCyc: PWY-5041;KEGG: 00270+3.3.1.1	"S-adenosyl-L-methionine cycle II";"Cysteine and methionine metabolism"
XP_046429054.1	1	Reactome: R-HSA-1632852	"Macroautophagy"
XP_046416075.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046420213.1	6	Reactome: R-HSA-9640463;MetaCyc: PWY-6733;KEGG: 00073+1.2.1.84;MetaCyc: PWY-7656;MetaCyc: PWY-5884;MetaCyc: PWY-7782	"Wax biosynthesis";"Sporopollenin precursors biosynthesis";"Cutin, suberine and wax biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Wax esters biosynthesis I";"Plasmalogen biosynthesis"
XP_046417884.1	6	Reactome: R-HSA-141444;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813;Reactome: R-HSA-68877;Reactome: R-HSA-2500257;Reactome: R-HSA-5663220	"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids";"Mitotic Prometaphase";"Resolution of Sister Chromatid Cohesion";"RHO GTPases Activate Formins"
XP_046421535.1	1	Reactome: R-HSA-204005	"COPII-mediated vesicle transport"
XP_046418017.1	1	Reactome: R-HSA-5223345	"Miscellaneous transport and binding events"
XP_046429319.1	3	MetaCyc: PWY-7546;Reactome: R-HSA-5358493;MetaCyc: PWY-6482	"Diphthamide biosynthesis II (eukaryotes)";"Synthesis of diphthamide-EEF2";"Diphthamide biosynthesis I (archaea)"
XP_046429524.1	2	Reactome: R-HSA-8876198;Reactome: R-HSA-5357905	"RAB GEFs exchange GTP for GDP on RABs";"Regulation of TNFR1 signaling"
XP_046427496.1	2	Reactome: R-HSA-5576893;Reactome: R-HSA-5576892	"Phase 2 - plateau phase";"Phase 0 - rapid depolarisation"
XP_046409675.1	5	Reactome: R-HSA-9639288;Reactome: R-HSA-917977;Reactome: R-HSA-77387;Reactome: R-HSA-1222556;Reactome: R-HSA-983712	"Amino acids regulate mTORC1";"Transferrin endocytosis and recycling";"Insulin receptor recycling";"ROS and RNS production in phagocytes";"Ion channel transport"
XP_046422918.1	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
XP_046426301.1	2	KEGG: 00450+2.7.9.3;MetaCyc: PWY-6281	"Selenocompound metabolism";"L-selenocysteine biosynthesis II (archaea and eukaryotes)"
XP_046420665.1	2	KEGG: 00030+2.7.6.1;KEGG: 00230+2.7.6.1	"Pentose phosphate pathway";"Purine metabolism"
XP_046419989.1	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
XP_046427725.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_046425158.1	1	Reactome: R-HSA-418990	"Adherens junctions interactions"
XP_046431972.1	34	Reactome: R-HSA-73779;Reactome: R-HSA-6782135;Reactome: R-HSA-8939236;Reactome: R-HSA-167160;Reactome: R-HSA-167246;Reactome: R-HSA-69656;Reactome: R-HSA-427413;Reactome: R-HSA-75953;Reactome: R-HSA-69202;Reactome: R-HSA-167200;Reactome: R-HSA-6796648;Reactome: R-HSA-77075;Reactome: R-HSA-674695;Reactome: R-HSA-5696395;Reactome: R-HSA-167152;Reactome: R-HSA-73772;Reactome: R-HSA-167172;Reactome: R-HSA-69231;Reactome: R-HSA-73863;Reactome: R-HSA-6781827;Reactome: R-HSA-167158;Reactome: R-HSA-73762;Reactome: R-HSA-6781823;Reactome: R-HSA-6807505;Reactome: R-HSA-167162;Reactome: R-HSA-69273;Reactome: R-HSA-113418;Reactome: R-HSA-6782210;Reactome: R-HSA-72086;Reactome: R-HSA-73776;Reactome: R-HSA-167161;Reactome: R-HSA-75955;Reactome: R-HSA-76042;Reactome: R-HSA-112382	"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Dual incision in TC-NER";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Tat-mediated elongation of the HIV-1 transcript";"Cyclin A:Cdk2-associated events at S phase entry";"NoRC negatively regulates rRNA expression";"RNA Polymerase II Transcription Initiation";"Cyclin E associated events during G1/S transition";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Pol II CTD phosphorylation and interaction with CE";"RNA Polymerase II Pre-transcription Events";"Formation of Incision Complex in GG-NER";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Polymerase I Promoter Escape";"Transcription of the HIV genome";"Cyclin D associated events in G1";"RNA Polymerase I Transcription Termination";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Formation of the HIV-1 Early Elongation Complex";"RNA Polymerase I Transcription Initiation";"Formation of TC-NER Pre-Incision Complex";"RNA polymerase II transcribes snRNA genes";"RNA Polymerase II HIV Promoter Escape";"Cyclin A/B1/B2 associated events during G2/M transition";"Formation of the Early Elongation Complex";"Gap-filling DNA repair synthesis and ligation in TC-NER";"mRNA Capping";"RNA Polymerase II Promoter Escape";"HIV Transcription Initiation";"RNA Polymerase II Transcription Elongation";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Formation of RNA Pol II elongation complex"
XP_046428745.1	2	Reactome: R-HSA-983168;Reactome: R-HSA-8951664	"Antigen processing: Ubiquitination & Proteasome degradation";"Neddylation"
XP_046427232.1	8	MetaCyc: PWY-7193;Reactome: R-HSA-6798695;Reactome: R-HSA-73614;MetaCyc: PWY-7199;MetaCyc: PWY-6556;KEGG: 00240+3.5.4.5;KEGG: 00983+3.5.4.5;MetaCyc: PWY-7181	"Pyrimidine ribonucleosides salvage I";"Neutrophil degranulation";"Pyrimidine salvage";"Pyrimidine deoxyribonucleosides salvage";"Pyrimidine ribonucleosides salvage II";"Pyrimidine metabolism";"Drug metabolism - other enzymes";"Pyrimidine deoxyribonucleosides degradation"
XP_046423144.1	18	KEGG: 00240+2.7.4.6;MetaCyc: PWY-7198;MetaCyc: PWY-7222;MetaCyc: PWY-7221;MetaCyc: PWY-6545;KEGG: 00230+2.7.4.6;MetaCyc: PWY-7187;Reactome: R-HSA-499943;MetaCyc: PWY-7184;MetaCyc: PWY-7210;MetaCyc: PWY-7197;MetaCyc: PWY-7224;MetaCyc: PWY-7227;MetaCyc: PWY-7226;MetaCyc: PWY-7220;KEGG: 00983+2.7.4.6;MetaCyc: PWY-7176;MetaCyc: PWY-7205	"Pyrimidine metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Guanosine deoxyribonucleotides de novo biosynthesis II";"Guanosine ribonucleotides de novo biosynthesis";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Purine metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis II";"Interconversion of nucleotide di- and triphosphates";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Pyrimidine deoxyribonucleotide phosphorylation";"Purine deoxyribonucleosides salvage";"Adenosine deoxyribonucleotides de novo biosynthesis";"Guanosine deoxyribonucleotides de novo biosynthesis I";"Adenosine deoxyribonucleotides de novo biosynthesis II";"Drug metabolism - other enzymes";"UTP and CTP de novo biosynthesis";"CMP phosphorylation"
XP_046420527.1	40	Reactome: R-HSA-5601884;Reactome: R-HSA-167172;Reactome: R-HSA-6803529;Reactome: R-HSA-167152;Reactome: R-HSA-167290;Reactome: R-HSA-167200;Reactome: R-HSA-6796648;Reactome: R-HSA-77075;Reactome: R-HSA-167242;Reactome: R-HSA-674695;Reactome: R-HSA-167238;Reactome: R-HSA-72165;Reactome: R-HSA-167246;Reactome: R-HSA-75953;Reactome: R-HSA-167160;Reactome: R-HSA-6782135;Reactome: R-HSA-73779;Reactome: R-HSA-167243;Reactome: R-HSA-72163;Reactome: R-HSA-112382;Reactome: R-HSA-75955;Reactome: R-HSA-72203;Reactome: R-HSA-76042;Reactome: R-HSA-5617472;Reactome: R-HSA-9018519;Reactome: R-HSA-8851708;Reactome: R-HSA-167161;Reactome: R-HSA-168325;Reactome: R-HSA-73776;Reactome: R-HSA-72086;Reactome: R-HSA-203927;Reactome: R-HSA-113418;Reactome: R-HSA-6782210;Reactome: R-HSA-167162;Reactome: R-HSA-6807505;Reactome: R-HSA-6781823;Reactome: R-HSA-5578749;Reactome: R-HSA-167287;Reactome: R-HSA-167158;Reactome: R-HSA-6781827	"PIWI-interacting RNA (piRNA) biogenesis";"Transcription of the HIV genome";"FGFR2 alternative splicing";"Formation of HIV elongation complex in the absence of HIV Tat";"Pausing and recovery of HIV elongation";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Pol II CTD phosphorylation and interaction with CE";"Abortive elongation of HIV-1 transcript in the absence of Tat";"RNA Polymerase II Pre-transcription Events";"Pausing and recovery of Tat-mediated HIV elongation";"mRNA Splicing - Minor Pathway";"Tat-mediated elongation of the HIV-1 transcript";"RNA Polymerase II Transcription Initiation";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Dual incision in TC-NER";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Tat-mediated HIV elongation arrest and recovery";"mRNA Splicing - Major Pathway";"Formation of RNA Pol II elongation complex";"RNA Polymerase II Transcription Elongation";"Processing of Capped Intron-Containing Pre-mRNA";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Estrogen-dependent gene expression";"Signaling by FGFR2 IIIa TM";"HIV Transcription Initiation";"Viral Messenger RNA Synthesis";"RNA Polymerase II Promoter Escape";"mRNA Capping";"MicroRNA (miRNA) biogenesis";"Formation of the Early Elongation Complex";"Gap-filling DNA repair synthesis and ligation in TC-NER";"RNA Polymerase II HIV Promoter Escape";"RNA polymerase II transcribes snRNA genes";"Formation of TC-NER Pre-Incision Complex";"Transcriptional regulation by small RNAs";"HIV elongation arrest and recovery";"Formation of the HIV-1 Early Elongation Complex";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)"
XP_046421879.1	3	Reactome: R-HSA-8939902;Reactome: R-HSA-6785807;Reactome: R-HSA-8878166	"Regulation of RUNX2 expression and activity";"Interleukin-4 and Interleukin-13 signaling";"Transcriptional regulation by RUNX2"
XP_046416720.1	6	Reactome: R-HSA-4086398;Reactome: R-HSA-4411364;Reactome: R-HSA-3769402;Reactome: R-HSA-201722;Reactome: R-HSA-4641265;Reactome: R-HSA-8951430	"Ca2+ pathway";"Binding of TCF/LEF:CTNNB1 to target gene promoters";"Deactivation of the beta-catenin transactivating complex";"Formation of the beta-catenin:TCF transactivating complex";"Repression of WNT target genes";"RUNX3 regulates WNT signaling"
XP_046424310.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_046421285.1	6	Reactome: R-HSA-2467813;Reactome: R-HSA-68877;Reactome: R-HSA-141444;Reactome: R-HSA-9648025;Reactome: R-HSA-2500257;Reactome: R-HSA-5663220	"Separation of Sister Chromatids";"Mitotic Prometaphase";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"EML4 and NUDC in mitotic spindle formation";"Resolution of Sister Chromatid Cohesion";"RHO GTPases Activate Formins"
XP_046435391.1	2	Reactome: R-HSA-196783;KEGG: 00770+6.3.2.5	"Coenzyme A biosynthesis";"Pantothenate and CoA biosynthesis"
XP_046419127.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_046435790.1	2	Reactome: R-HSA-5576892;Reactome: R-HSA-5576893	"Phase 0 - rapid depolarisation";"Phase 2 - plateau phase"
XP_046417805.1	5	Reactome: R-HSA-1266695;Reactome: R-HSA-201722;Reactome: R-HSA-8939243;Reactome: R-HSA-3247509;Reactome: R-HSA-3214858	"Interleukin-7 signaling";"Formation of the beta-catenin:TCF transactivating complex";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"Chromatin modifying enzymes";"RMTs methylate histone arginines"
XP_046435513.1	14	Reactome: R-HSA-112382;Reactome: R-HSA-113418;Reactome: R-HSA-167243;Reactome: R-HSA-167238;Reactome: R-HSA-75955;Reactome: R-HSA-167246;Reactome: R-HSA-167290;Reactome: R-HSA-167152;Reactome: R-HSA-167158;Reactome: R-HSA-167242;Reactome: R-HSA-674695;Reactome: R-HSA-6796648;Reactome: R-HSA-167200;Reactome: R-HSA-167287	"Formation of RNA Pol II elongation complex";"Formation of the Early Elongation Complex";"Tat-mediated HIV elongation arrest and recovery";"Pausing and recovery of Tat-mediated HIV elongation";"RNA Polymerase II Transcription Elongation";"Tat-mediated elongation of the HIV-1 transcript";"Pausing and recovery of HIV elongation";"Formation of HIV elongation complex in the absence of HIV Tat";"Formation of the HIV-1 Early Elongation Complex";"Abortive elongation of HIV-1 transcript in the absence of Tat";"RNA Polymerase II Pre-transcription Events";"TP53 Regulates Transcription of DNA Repair Genes";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"HIV elongation arrest and recovery"
XP_046430396.1	1	Reactome: R-HSA-1474228	"Degradation of the extracellular matrix"
XP_046415100.1	4	Reactome: R-HSA-2408522;Reactome: R-HSA-379726;KEGG: 00970+6.1.1.18;Reactome: R-HSA-379716	"Selenoamino acid metabolism";"Mitochondrial tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis";"Cytosolic tRNA aminoacylation"
XP_046411164.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046424036.1	1	Reactome: R-HSA-2022928	"HS-GAG biosynthesis"
XP_046431034.1	5	Reactome: R-HSA-5693571;Reactome: R-HSA-3232118;Reactome: R-HSA-69473;Reactome: R-HSA-5693607;Reactome: R-HSA-5693565	"Nonhomologous End-Joining (NHEJ)";"SUMOylation of transcription factors";"G2/M DNA damage checkpoint";"Processing of DNA double-strand break ends";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"
XP_046421622.1	3	Reactome: R-HSA-1855167;MetaCyc: PWY-6369;KEGG: 04070+2.7.4.24+2.7.4.21	"Synthesis of pyrophosphates in the cytosol";"Inositol diphosphates biosynthesis";"Phosphatidylinositol signaling system"
XP_046414792.1	16	Reactome: R-HSA-8866427;Reactome: R-HSA-182218;Reactome: R-HSA-167590;Reactome: R-HSA-416993;Reactome: R-HSA-3928665;Reactome: R-HSA-196025;Reactome: R-HSA-5140745;Reactome: R-HSA-5099900;Reactome: R-HSA-190873;Reactome: R-HSA-164939;Reactome: R-HSA-2132295;Reactome: R-HSA-8856828;Reactome: R-HSA-177504;Reactome: R-HSA-8964038;Reactome: R-HSA-437239;Reactome: R-HSA-8856825	"VLDLR internalisation and degradation";"Nef Mediated CD8 Down-regulation";"Nef Mediated CD4 Down-regulation";"Trafficking of GluR2-containing AMPA receptors";"EPH-ephrin mediated repulsion of cells";"Formation of annular gap junctions";"WNT5A-dependent internalization of FZD2, FZD5 and ROR2";"WNT5A-dependent internalization of FZD4";"Gap junction degradation";"Nef mediated downregulation of CD28 cell surface expression";"MHC class II antigen presentation";"Clathrin-mediated endocytosis";"Retrograde neurotrophin signalling";"LDL clearance";"Recycling pathway of L1";"Cargo recognition for clathrin-mediated endocytosis"
XP_046410266.1	2	KEGG: 00620+3.1.2.6;MetaCyc: PWY-5386	"Pyruvate metabolism";"Methylglyoxal degradation I"
XP_046414691.1	1	Reactome: R-HSA-432720	"Lysosome Vesicle Biogenesis"
XP_046421020.1	6	MetaCyc: PWY-5884;MetaCyc: PWY-7782;KEGG: 00073+1.2.1.84;MetaCyc: PWY-7656;Reactome: R-HSA-9640463;MetaCyc: PWY-6733	"Wax esters biosynthesis I";"Plasmalogen biosynthesis";"Cutin, suberine and wax biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Wax biosynthesis";"Sporopollenin precursors biosynthesis"
XP_046435660.1	1	Reactome: R-HSA-611105	"Respiratory electron transport"
XP_046414663.1	3	MetaCyc: PWY-4361;Reactome: R-HSA-1237112;KEGG: 00270+1.13.11.54	"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I";"Methionine salvage pathway";"Cysteine and methionine metabolism"
XP_046428788.1	1	Reactome: R-HSA-977225	"Amyloid fiber formation"
XP_046416553.1	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
XP_046412499.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_046416355.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046433039.1	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
XP_046429173.1	2	Reactome: R-HSA-381340;Reactome: R-HSA-1989781	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression"
XP_046417581.1	12	Reactome: R-HSA-167243;Reactome: R-HSA-167238;Reactome: R-HSA-112382;Reactome: R-HSA-75955;Reactome: R-HSA-167246;Reactome: R-HSA-6804756;Reactome: R-HSA-167152;Reactome: R-HSA-167290;Reactome: R-HSA-167200;Reactome: R-HSA-6796648;Reactome: R-HSA-167287;Reactome: R-HSA-674695	"Tat-mediated HIV elongation arrest and recovery";"Pausing and recovery of Tat-mediated HIV elongation";"Formation of RNA Pol II elongation complex";"RNA Polymerase II Transcription Elongation";"Tat-mediated elongation of the HIV-1 transcript";"Regulation of TP53 Activity through Phosphorylation";"Formation of HIV elongation complex in the absence of HIV Tat";"Pausing and recovery of HIV elongation";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"TP53 Regulates Transcription of DNA Repair Genes";"HIV elongation arrest and recovery";"RNA Polymerase II Pre-transcription Events"
XP_046422211.1	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
XP_046423275.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046431871.1	8	Reactome: R-HSA-8856828;Reactome: R-HSA-196025;Reactome: R-HSA-5099900;Reactome: R-HSA-5140745;Reactome: R-HSA-8856825;Reactome: R-HSA-190873;Reactome: R-HSA-432720;Reactome: R-HSA-3928665	"Clathrin-mediated endocytosis";"Formation of annular gap junctions";"WNT5A-dependent internalization of FZD4";"WNT5A-dependent internalization of FZD2, FZD5 and ROR2";"Cargo recognition for clathrin-mediated endocytosis";"Gap junction degradation";"Lysosome Vesicle Biogenesis";"EPH-ephrin mediated repulsion of cells"
XP_046418195.1	3	Reactome: R-HSA-6794361;Reactome: R-HSA-6798695;Reactome: R-HSA-264870	"Neurexins and neuroligins";"Neutrophil degranulation";"Caspase-mediated cleavage of cytoskeletal proteins"
XP_046430934.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_046412054.1	3	Reactome: R-HSA-983189;Reactome: R-HSA-6811434;Reactome: R-HSA-390471	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic";"Association of TriC/CCT with target proteins during biosynthesis"
XP_046418183.1	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
XP_046425166.1	1	Reactome: R-HSA-418990	"Adherens junctions interactions"
XP_046423729.1	2	Reactome: R-HSA-71336;KEGG: 00710+2.7.1.14	"Pentose phosphate pathway";"Carbon fixation in photosynthetic organisms"
XP_046426149.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046413159.1	1	Reactome: R-HSA-156842	"Eukaryotic Translation Elongation"
XP_046434647.1	1	Reactome: R-HSA-209968	"Thyroxine biosynthesis"
XP_046421614.1	3	KEGG: 04070+2.7.4.24+2.7.4.21;MetaCyc: PWY-6369;Reactome: R-HSA-1855167	"Phosphatidylinositol signaling system";"Inositol diphosphates biosynthesis";"Synthesis of pyrophosphates in the cytosol"
XP_046429442.1	1	Reactome: R-HSA-611105	"Respiratory electron transport"
XP_046422644.1	1	Reactome: R-HSA-2022377	"Metabolism of Angiotensinogen to Angiotensins"
XP_046428704.1	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046415104.1	11	KEGG: 00230+1.17.1.4;MetaCyc: PWY-5497;MetaCyc: PWY-6596;MetaCyc: PWY-6608;MetaCyc: PWY-6999;MetaCyc: PWY-6606;Reactome: R-HSA-74259;MetaCyc: PWY-5695;MetaCyc: PWY-6607;Reactome: R-HSA-8851680;MetaCyc: PWY-6538	"Purine metabolism";"Purine nucleobases degradation II (anaerobic)";"Adenosine nucleotides degradation I";"Guanosine nucleotides degradation III";"Theophylline degradation";"Guanosine nucleotides degradation II";"Purine catabolism";"Inosine 5'-phosphate degradation";"Guanosine nucleotides degradation I";"Butyrophilin (BTN) family interactions";"Caffeine degradation III (bacteria, via demethylation)"
XP_046425305.1	15	Reactome: R-HSA-167200;Reactome: R-HSA-6796648;Reactome: R-HSA-176034;Reactome: R-HSA-167287;Reactome: R-HSA-674695;Reactome: R-HSA-9018519;Reactome: R-HSA-167152;Reactome: R-HSA-167290;Reactome: R-HSA-6807505;Reactome: R-HSA-75955;Reactome: R-HSA-167246;Reactome: R-HSA-167243;Reactome: R-HSA-167238;Reactome: R-HSA-2173796;Reactome: R-HSA-112382	"Formation of HIV-1 elongation complex containing HIV-1 Tat";"TP53 Regulates Transcription of DNA Repair Genes";"Interactions of Tat with host cellular proteins";"HIV elongation arrest and recovery";"RNA Polymerase II Pre-transcription Events";"Estrogen-dependent gene expression";"Formation of HIV elongation complex in the absence of HIV Tat";"Pausing and recovery of HIV elongation";"RNA polymerase II transcribes snRNA genes";"RNA Polymerase II Transcription Elongation";"Tat-mediated elongation of the HIV-1 transcript";"Tat-mediated HIV elongation arrest and recovery";"Pausing and recovery of Tat-mediated HIV elongation";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"Formation of RNA Pol II elongation complex"
XP_046417346.1	2	MetaCyc: PWY-7802;MetaCyc: PWY-7799	"N-end rule pathway II (prokaryotic)";"Arg/N-end rule pathway (eukaryotic)"
XP_046425913.1	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
XP_046426114.1	16	Reactome: R-HSA-975871;Reactome: R-HSA-209543;Reactome: R-HSA-3134963;Reactome: R-HSA-9020702;Reactome: R-HSA-975138;Reactome: R-HSA-1257604;Reactome: R-HSA-5603041;Reactome: R-HSA-975155;Reactome: R-HSA-5603037;Reactome: R-HSA-5602498;Reactome: R-HSA-5602680;Reactome: R-HSA-1236974;Reactome: R-HSA-975110;Reactome: R-HSA-166058;Reactome: R-HSA-1810476;Reactome: R-HSA-6811558	"MyD88 cascade initiated on plasma membrane";"p75NTR recruits signalling complexes";"DEx/H-box helicases activate type I IFN and inflammatory cytokines production";"Interleukin-1 signaling";"TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation";"PIP3 activates AKT signaling";"IRAK4 deficiency (TLR2/4)";"MyD88 dependent cascade initiated on endosome";"IRAK4 deficiency (TLR5)";"MyD88 deficiency (TLR2/4)";"MyD88 deficiency (TLR5)";"ER-Phagosome pathway";"TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling";"MyD88:MAL(TIRAP) cascade initiated on plasma membrane";"RIP-mediated NFkB activation via ZBP1";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"
XP_046410284.1	2	Reactome: R-HSA-8869496;Reactome: R-HSA-6790901	"TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation";"rRNA modification in the nucleus and cytosol"
XP_046416487.1	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276	"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination"
XP_046424043.1	1	Reactome: R-HSA-435368	"Zinc efflux and compartmentalization by the SLC30 family"
XP_046433150.1	1	Reactome: R-HSA-1632852	"Macroautophagy"
XP_046430964.1	1	Reactome: R-HSA-8850843	"Phosphate bond hydrolysis by NTPDase proteins"
XP_046436105.1	1	KEGG: 00970+6.1.1.2	"Aminoacyl-tRNA biosynthesis"
XP_046435961.1	13	MetaCyc: PWY-6545;KEGG: 00240+1.17.4.1;MetaCyc: PWY-7222;MetaCyc: PWY-7184;MetaCyc: PWY-7210;Reactome: R-HSA-499943;MetaCyc: PWY-7227;MetaCyc: PWY-7198;MetaCyc: PWY-7226;KEGG: 00480+1.17.4.1;KEGG: 00230+1.17.4.1;KEGG: 00983+1.17.4.1;MetaCyc: PWY-7220	"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Pyrimidine metabolism";"Guanosine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Interconversion of nucleotide di- and triphosphates";"Adenosine deoxyribonucleotides de novo biosynthesis";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Guanosine deoxyribonucleotides de novo biosynthesis I";"Glutathione metabolism";"Purine metabolism";"Drug metabolism - other enzymes";"Adenosine deoxyribonucleotides de novo biosynthesis II"
XP_046431642.1	2	Reactome: R-HSA-380320;Reactome: R-HSA-380270	"Recruitment of NuMA to mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes"
XP_046411463.1	2	KEGG: 00230+2.7.4.8;MetaCyc: PWY-7221	"Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis"
XP_046432155.1	1	Reactome: R-HSA-390522	"Striated Muscle Contraction"
XP_046416766.1	2	Reactome: R-HSA-1989781;Reactome: R-HSA-381340	"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation"
XP_046419486.1	5	Reactome: R-HSA-77595;Reactome: R-HSA-73856;Reactome: R-HSA-72187;Reactome: R-HSA-72163;Reactome: R-HSA-6784531	"Processing of Intronless Pre-mRNAs";"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing";"mRNA Splicing - Major Pathway";"tRNA processing in the nucleus"
XP_046435380.1	2	Reactome: R-HSA-8856825;Reactome: R-HSA-8856828	"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis"
XP_046416588.1	5	Reactome: R-HSA-917977;Reactome: R-HSA-9639288;Reactome: R-HSA-1222556;Reactome: R-HSA-77387;Reactome: R-HSA-983712	"Transferrin endocytosis and recycling";"Amino acids regulate mTORC1";"ROS and RNS production in phagocytes";"Insulin receptor recycling";"Ion channel transport"
XP_046432737.1	7	Reactome: R-HSA-380284;Reactome: R-HSA-5620912;Reactome: R-HSA-8854518;Reactome: R-HSA-380259;Reactome: R-HSA-380320;Reactome: R-HSA-380270;Reactome: R-HSA-2565942	"Loss of proteins required for interphase microtubule organization from the centrosome";"Anchoring of the basal body to the plasma membrane";"AURKA Activation by TPX2";"Loss of Nlp from mitotic centrosomes";"Recruitment of NuMA to mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes";"Regulation of PLK1 Activity at G2/M Transition"
XP_046429586.1	5	Reactome: R-HSA-532668;Reactome: R-HSA-901042;Reactome: R-HSA-8957275;Reactome: R-HSA-381426;Reactome: R-HSA-879415	"N-glycan trimming in the ER and Calnexin/Calreticulin cycle";"Calnexin/calreticulin cycle";"Post-translational protein phosphorylation";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"Advanced glycosylation endproduct receptor signaling"
XP_046423331.1	2	Reactome: R-HSA-983231;Reactome: R-HSA-8949215	"Factors involved in megakaryocyte development and platelet production";"Mitochondrial calcium ion transport"
XP_046433891.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_046423390.1	34	Reactome: R-HSA-3301854;Reactome: R-HSA-5578749;Reactome: R-HSA-180746;Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-168333;Reactome: R-HSA-159227;Reactome: R-HSA-4570464;Reactome: R-HSA-9639288;Reactome: R-HSA-159236;Reactome: R-HSA-141444;Reactome: R-HSA-168325;Reactome: R-HSA-9609690;Reactome: R-HSA-170822;Reactome: R-HSA-180910;Reactome: R-HSA-4085377;Reactome: R-HSA-165054;Reactome: R-HSA-6784531;Reactome: R-HSA-5619107;Reactome: R-HSA-168276;Reactome: R-HSA-191859;Reactome: R-HSA-159230;Reactome: R-HSA-4615885;Reactome: R-HSA-168271;Reactome: R-HSA-9610379;Reactome: R-HSA-9648025;Reactome: R-HSA-3108214;Reactome: R-HSA-1169408;Reactome: R-HSA-2467813;Reactome: R-HSA-159231;Reactome: R-HSA-3232142;Reactome: R-HSA-3371453;Reactome: R-HSA-2500257;Reactome: R-HSA-4551638	"Nuclear Pore Complex (NPC) Disassembly";"Transcriptional regulation by small RNAs";"Nuclear import of Rev protein";"Mitotic Prometaphase";"RHO GTPases Activate Formins";"NEP/NS2 Interacts with the Cellular Export Machinery";"Transport of the SLBP independent Mature mRNA";"SUMOylation of RNA binding proteins";"Amino acids regulate mTORC1";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Viral Messenger RNA Synthesis";"HCMV Early Events";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Vpr-mediated nuclear import of PICs";"SUMOylation of SUMOylation proteins";"Rev-mediated nuclear export of HIV RNA";"tRNA processing in the nucleus";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"NS1 Mediated Effects on Host Pathways";"snRNP Assembly";"Transport of the SLBP Dependant Mature mRNA";"SUMOylation of DNA replication proteins";"Transport of Ribonucleoproteins into the Host Nucleus";"HCMV Late Events";"EML4 and NUDC in mitotic spindle formation";"SUMOylation of DNA damage response and repair proteins";"ISG15 antiviral mechanism";"Separation of Sister Chromatids";"Transport of Mature mRNA Derived from an Intronless Transcript";"SUMOylation of ubiquitinylation proteins";"Regulation of HSF1-mediated heat shock response";"Resolution of Sister Chromatid Cohesion";"SUMOylation of chromatin organization proteins"
XP_046416936.1	9	Reactome: R-HSA-5693579;Reactome: R-HSA-5685942;Reactome: R-HSA-5693607;Reactome: R-HSA-5693568;Reactome: R-HSA-5685938;Reactome: R-HSA-5693554;Reactome: R-HSA-5693616;Reactome: R-HSA-6804756;Reactome: R-HSA-69473	"Homologous DNA Pairing and Strand Exchange";"HDR through Homologous Recombination (HRR)";"Processing of DNA double-strand break ends";"Resolution of D-loop Structures through Holliday Junction Intermediates";"HDR through Single Strand Annealing (SSA)";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Presynaptic phase of homologous DNA pairing and strand exchange";"Regulation of TP53 Activity through Phosphorylation";"G2/M DNA damage checkpoint"
XP_046414112.1	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
XP_046412523.1	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_046419508.1	3	Reactome: R-HSA-3000171;Reactome: R-HSA-8874081;Reactome: R-HSA-3000157	"Non-integrin membrane-ECM interactions";"MET activates PTK2 signaling";"Laminin interactions"
XP_046431844.1	14	Reactome: R-HSA-426496;Reactome: R-HSA-9029569;Reactome: R-HSA-5687128;Reactome: R-HSA-9022692;Reactome: R-HSA-203927;Reactome: R-HSA-8948700;Reactome: R-HSA-5628897;Reactome: R-HSA-8943723;Reactome: R-HSA-1912408;Reactome: R-HSA-4086398;Reactome: R-HSA-8986944;Reactome: R-HSA-8934593;Reactome: R-HSA-9018519;Reactome: R-HSA-426486	"Post-transcriptional silencing by small RNAs";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"MAPK6/MAPK4 signaling";"Regulation of MECP2 expression and activity";"MicroRNA (miRNA) biogenesis";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"TP53 Regulates Metabolic Genes";"Regulation of PTEN mRNA translation";"Pre-NOTCH Transcription and Translation";"Ca2+ pathway";"Transcriptional Regulation by MECP2";"Regulation of RUNX1 Expression and Activity";"Estrogen-dependent gene expression";"Small interfering RNA (siRNA) biogenesis"
XP_046419988.1	19	Reactome: R-HSA-5578775;Reactome: R-HSA-399719;Reactome: R-HSA-936837;Reactome: R-HSA-9609736;Reactome: R-HSA-9617324;Reactome: R-HSA-5576892;Reactome: R-HSA-877300;Reactome: R-HSA-9022692;Reactome: R-HSA-111932;Reactome: R-HSA-438066;Reactome: R-HSA-6802955;Reactome: R-HSA-6802952;Reactome: R-HSA-9649948;Reactome: R-HSA-3371571;Reactome: R-HSA-442982;Reactome: R-HSA-9620244;Reactome: R-HSA-5673000;Reactome: R-HSA-6802946;Reactome: R-HSA-5673001	"Ion homeostasis";"Trafficking of AMPA receptors";"Ion transport by P-type ATPases";"Assembly and cell surface presentation of NMDA receptors";"Negative regulation of NMDA receptor-mediated neuronal transmission";"Phase 0 - rapid depolarisation";"Interferon gamma signaling";"Regulation of MECP2 expression and activity";"CaMK IV-mediated phosphorylation of CREB";"Unblocking of NMDA receptors, glutamate binding and activation";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"Signaling by BRAF and RAF fusions";"Signaling downstream of RAS mutants";"HSF1-dependent transactivation";"Ras activation upon Ca2+ influx through NMDA receptor";"Long-term potentiation";"RAF activation";"Signaling by moderate kinase activity BRAF mutants";"RAF/MAP kinase cascade"
XP_046428575.1	3	Reactome: R-HSA-193648;Reactome: R-HSA-194840;Reactome: R-HSA-416482	"NRAGE signals death through JNK";"Rho GTPase cycle";"G alpha (12/13) signalling events"
XP_046413383.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_046430966.1	1	Reactome: R-HSA-8850843	"Phosphate bond hydrolysis by NTPDase proteins"
XP_046429529.1	2	Reactome: R-HSA-5357905;Reactome: R-HSA-8876198	"Regulation of TNFR1 signaling";"RAB GEFs exchange GTP for GDP on RABs"
XP_046434691.1	3	KEGG: 00230+3.5.4.6;Reactome: R-HSA-74217;MetaCyc: PWY-6596	"Purine metabolism";"Purine salvage";"Adenosine nucleotides degradation I"
XP_046433912.1	1	Reactome: R-HSA-8876725	"Protein methylation"
XP_046412155.1	1	Reactome: R-HSA-6814848	"Glycerophospholipid catabolism"
XP_046420377.1	3	Reactome: R-HSA-5663213;Reactome: R-HSA-2029482;Reactome: R-HSA-4420097	"RHO GTPases Activate WASPs and WAVEs";"Regulation of actin dynamics for phagocytic cup formation";"VEGFA-VEGFR2 Pathway"
XP_046414849.1	1	Reactome: R-HSA-212300	"PRC2 methylates histones and DNA"
XP_046422851.1	1	Reactome: R-HSA-426048	"Arachidonate production from DAG"
XP_046419522.1	3	Reactome: R-HSA-3000171;Reactome: R-HSA-8874081;Reactome: R-HSA-3000157	"Non-integrin membrane-ECM interactions";"MET activates PTK2 signaling";"Laminin interactions"
XP_046434405.1	1	Reactome: R-HSA-4085001	"Sialic acid metabolism"
XP_046433256.1	13	MetaCyc: PWY-6613;KEGG: 00670+6.3.4.3;MetaCyc: PWY-5030;Reactome: R-HSA-196757;KEGG: 00670+1.5.1.5+3.5.4.9;MetaCyc: PWY-7909;MetaCyc: PWY-3841;MetaCyc: PWY-1722;MetaCyc: PWY-2161;MetaCyc: PWY-5497;KEGG: 00720+6.3.4.3;KEGG: 00720+1.5.1.5+3.5.4.9;MetaCyc: PWY-2201	"Tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate";"One carbon pool by folate";"L-histidine degradation III";"Metabolism of folate and pterines";"One carbon pool by folate";"Formaldehyde oxidation VII (THF pathway)";"Folate transformations II (plants)";"Formate assimilation into 5,10-methylenetetrahydrofolate";"Folate polyglutamylation";"Purine nucleobases degradation II (anaerobic)";"Carbon fixation pathways in prokaryotes";"Carbon fixation pathways in prokaryotes";"Folate transformations I"
XP_046412649.1	4	Reactome: R-HSA-350054;Reactome: R-HSA-2894862;Reactome: R-HSA-2122947;Reactome: R-HSA-2644606	"Notch-HLH transcription pathway";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"NOTCH1 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 PEST Domain Mutants"
XP_046421001.1	1	Reactome: R-HSA-432047	"Passive transport by Aquaporins"
XP_046421671.1	2	Reactome: R-HSA-72165;Reactome: R-HSA-72163	"mRNA Splicing - Minor Pathway";"mRNA Splicing - Major Pathway"
XP_046416159.1	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
XP_046419893.1	19	Reactome: R-HSA-399719;Reactome: R-HSA-5578775;Reactome: R-HSA-936837;Reactome: R-HSA-9609736;Reactome: R-HSA-877300;Reactome: R-HSA-5576892;Reactome: R-HSA-9617324;Reactome: R-HSA-438066;Reactome: R-HSA-9022692;Reactome: R-HSA-111932;Reactome: R-HSA-6802955;Reactome: R-HSA-3371571;Reactome: R-HSA-9649948;Reactome: R-HSA-6802952;Reactome: R-HSA-442982;Reactome: R-HSA-6802946;Reactome: R-HSA-5673000;Reactome: R-HSA-9620244;Reactome: R-HSA-5673001	"Trafficking of AMPA receptors";"Ion homeostasis";"Ion transport by P-type ATPases";"Assembly and cell surface presentation of NMDA receptors";"Interferon gamma signaling";"Phase 0 - rapid depolarisation";"Negative regulation of NMDA receptor-mediated neuronal transmission";"Unblocking of NMDA receptors, glutamate binding and activation";"Regulation of MECP2 expression and activity";"CaMK IV-mediated phosphorylation of CREB";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"HSF1-dependent transactivation";"Signaling downstream of RAS mutants";"Signaling by BRAF and RAF fusions";"Ras activation upon Ca2+ influx through NMDA receptor";"Signaling by moderate kinase activity BRAF mutants";"RAF activation";"Long-term potentiation";"RAF/MAP kinase cascade"
XP_046426102.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046431773.1	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840	"Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation"
XP_046425267.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_046417172.1	2	Reactome: R-HSA-390471;Reactome: R-HSA-1660662	"Association of TriC/CCT with target proteins during biosynthesis";"Glycosphingolipid metabolism"
XP_046419253.1	2	Reactome: R-HSA-909733;Reactome: R-HSA-8983711	"Interferon alpha/beta signaling";"OAS antiviral response"
XP_046412963.1	13	KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;Reactome: R-HSA-3928662;Reactome: R-HSA-5627117;Reactome: R-HSA-416572;Reactome: R-HSA-4420097;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;Reactome: R-HSA-3928663;KEGG: 04150+2.7.11.1;Reactome: R-HSA-416482;KEGG: 04151+2.7.11.1	"Thermogenesis";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"EPHB-mediated forward signaling";"RHO GTPases Activate ROCKs";"Sema4D induced cell migration and growth-cone collapse";"VEGFA-VEGFR2 Pathway";"Human cytomegalovirus infection";"Relaxin signaling pathway";"EPHA-mediated growth cone collapse";"mTOR signaling pathway";"G alpha (12/13) signalling events";"PI3K-Akt signaling pathway"
XP_046415607.1	3	KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16	"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
XP_046432034.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_046414446.1	1	Reactome: R-HSA-5389840	"Mitochondrial translation elongation"
XP_046419501.1	3	Reactome: R-HSA-3000157;Reactome: R-HSA-3000171;Reactome: R-HSA-8874081	"Laminin interactions";"Non-integrin membrane-ECM interactions";"MET activates PTK2 signaling"
XP_046424980.1	11	Reactome: R-HSA-163359;Reactome: R-HSA-164378;Reactome: R-HSA-418555;Reactome: R-HSA-418597;Reactome: R-HSA-170660;Reactome: R-HSA-418594;Reactome: R-HSA-432040;Reactome: R-HSA-163615;Reactome: R-HSA-5610787;KEGG: 00230+4.6.1.1;Reactome: R-HSA-170670	"Glucagon signaling in metabolic regulation";"PKA activation in glucagon signalling";"G alpha (s) signalling events";"G alpha (z) signalling events";"Adenylate cyclase activating pathway";"G alpha (i) signalling events";"Vasopressin regulates renal water homeostasis via Aquaporins";"PKA activation";"Hedgehog 'off' state";"Purine metabolism";"Adenylate cyclase inhibitory pathway"
XP_046428998.1	1	Reactome: R-HSA-3299685	"Detoxification of Reactive Oxygen Species"
XP_046423464.1	1	Reactome: R-HSA-201681	"TCF dependent signaling in response to WNT"
XP_046414186.1	1	Reactome: R-HSA-1660662	"Glycosphingolipid metabolism"
XP_046429731.1	5	KEGG: 00510+1.3.1.94;Reactome: R-HSA-446199;Reactome: R-HSA-193048;MetaCyc: PWY-6129;Reactome: R-HSA-4755579	"N-Glycan biosynthesis";"Synthesis of Dolichyl-phosphate";"Androgen biosynthesis";"Dolichol and dolichyl phosphate biosynthesis";"Defective SRD5A3 causes SRD5A3-CDG (CDG-1q) and KHRZ"
XP_046423888.1	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
XP_046427066.1	3	KEGG: 00260+3.1.3.3;Reactome: R-HSA-977347;KEGG: 00680+3.1.3.3	"Glycine, serine and threonine metabolism";"Serine biosynthesis";"Methane metabolism"
XP_046423725.1	2	KEGG: 00710+2.7.1.14;Reactome: R-HSA-71336	"Carbon fixation in photosynthetic organisms";"Pentose phosphate pathway"
XP_046427956.1	2	Reactome: R-HSA-1989781;Reactome: R-HSA-2151201	"PPARA activates gene expression";"Transcriptional activation of mitochondrial biogenesis"
XP_046421919.1	12	KEGG: 00592+3.1.1.4;MetaCyc: PWY-7783;KEGG: 00590+3.1.1.4;KEGG: 00565+3.1.1.4;MetaCyc: PWY-6803;MetaCyc: PWY-8051;KEGG: 00564+3.1.1.4;MetaCyc: PWY-7417;KEGG: 00591+3.1.1.4;MetaCyc: PWY-7416;MetaCyc: PWY-8053;MetaCyc: PWY-7409	"alpha-Linolenic acid metabolism";"Plasmalogen degradation";"Arachidonic acid metabolism";"Ether lipid metabolism";"Phosphatidylcholine acyl editing";"Anandamide biosynthesis I";"Glycerophospholipid metabolism";"Phospholipid remodeling (phosphatidate, yeast)";"Linoleic acid metabolism";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Anandamide biosynthesis II";"Phospholipid remodeling (phosphatidylethanolamine, yeast)"
XP_046432138.1	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
XP_046424377.1	2	Reactome: R-HSA-6814122;Reactome: R-HSA-418594	"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"G alpha (i) signalling events"
XP_046419648.1	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276	"Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination"
XP_046435845.1	16	Reactome: R-HSA-6811558;Reactome: R-HSA-1963640;Reactome: R-HSA-1251985;Reactome: R-HSA-1250347;Reactome: R-HSA-5673001;Reactome: R-HSA-1250342;Reactome: R-HSA-6785631;Reactome: R-HSA-1236394;Reactome: R-HSA-8863795;Reactome: R-HSA-1963642;Reactome: R-HSA-1250196;Reactome: R-HSA-1227986;Reactome: R-HSA-8847993;Reactome: R-HSA-1257604;Reactome: R-HSA-9664565;Reactome: R-HSA-2219530	"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"GRB2 events in ERBB2 signaling";"Nuclear signaling by ERBB4";"SHC1 events in ERBB4 signaling";"RAF/MAP kinase cascade";"PI3K events in ERBB4 signaling";"ERBB2 Regulates Cell Motility";"Signaling by ERBB4";"Downregulation of ERBB2 signaling";"PI3K events in ERBB2 signaling";"SHC1 events in ERBB2 signaling";"Signaling by ERBB2";"ERBB2 Activates PTK6 Signaling";"PIP3 activates AKT signaling";"Signaling by ERBB2 KD Mutants";"Constitutive Signaling by Aberrant PI3K in Cancer"
XP_046410692.1	1	Reactome: R-HSA-1474228	"Degradation of the extracellular matrix"
XP_046430646.1	4	Reactome: R-HSA-3371497;Reactome: R-HSA-6811436;Reactome: R-HSA-6807878;Reactome: R-HSA-2132295	"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-independent Golgi-to-ER retrograde traffic";"COPI-mediated anterograde transport";"MHC class II antigen presentation"
XP_046431471.1	1	Reactome: R-HSA-163560	"Triglyceride catabolism"
XP_046421007.1	1	Reactome: R-HSA-432047	"Passive transport by Aquaporins"
XP_046417823.1	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046429540.1	1	Reactome: R-HSA-5620922	"BBSome-mediated cargo-targeting to cilium"
XP_046425000.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046427018.1	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
XP_046413827.1	1	Reactome: R-HSA-912446	"Meiotic recombination"
XP_046433227.1	3	Reactome: R-HSA-2024096;Reactome: R-HSA-6798695;Reactome: R-HSA-2206291	"HS-GAG degradation";"Neutrophil degranulation";"MPS IIIC - Sanfilippo syndrome C"
XP_046428253.1	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
XP_046421480.1	8	Reactome: R-HSA-165159;Reactome: R-HSA-380972;Reactome: R-HSA-1632852;Reactome: R-HSA-6798695;Reactome: R-HSA-166208;Reactome: R-HSA-5628897;Reactome: R-HSA-8943724;Reactome: R-HSA-9639288	"mTOR signalling";"Energy dependent regulation of mTOR by LKB1-AMPK";"Macroautophagy";"Neutrophil degranulation";"mTORC1-mediated signalling";"TP53 Regulates Metabolic Genes";"Regulation of PTEN gene transcription";"Amino acids regulate mTORC1"
XP_046427465.1	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_046420808.1	5	Reactome: R-HSA-9648895;Reactome: R-HSA-380994;Reactome: R-HSA-9633012;Reactome: R-HSA-8963693;KEGG: 00250+6.3.5.4	"Response of EIF2AK1 (HRI) to heme deficiency";"ATF4 activates genes in response to endoplasmic reticulum stress";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Aspartate and asparagine metabolism";"Alanine, aspartate and glutamate metabolism"
XP_046426145.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046423525.1	1	Reactome: R-HSA-8854214	"TBC/RABGAPs"
XP_046427950.1	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
XP_046409491.1	7	KEGG: 00983+1.1.1.205;Reactome: R-HSA-73817;KEGG: 00230+1.1.1.205;MetaCyc: PWY-7221;MetaCyc: PWY-5695;MetaCyc: PWY-6596;Reactome: R-HSA-6798695	"Drug metabolism - other enzymes";"Purine ribonucleoside monophosphate biosynthesis";"Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis";"Inosine 5'-phosphate degradation";"Adenosine nucleotides degradation I";"Neutrophil degranulation"
XP_046427515.1	2	Reactome: R-HSA-446193;KEGG: 00510+2.4.1.256	"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"N-Glycan biosynthesis"
XP_046436229.1	3	Reactome: R-HSA-5696394;Reactome: R-HSA-3214847;Reactome: R-HSA-5689603	"DNA Damage Recognition in GG-NER";"HATs acetylate histones";"UCH proteinases"
XP_046424286.1	18	MetaCyc: PWY-7417;Reactome: R-HSA-1482801;Reactome: R-HSA-1482922;MetaCyc: PWY-8051;Reactome: R-HSA-1482788;KEGG: 00565+3.1.1.4;Reactome: R-HSA-1483166;KEGG: 00590+3.1.1.4;KEGG: 00592+3.1.1.4;MetaCyc: PWY-7409;Reactome: R-HSA-1482839;MetaCyc: PWY-8053;MetaCyc: PWY-7416;KEGG: 00591+3.1.1.4;KEGG: 00564+3.1.1.4;MetaCyc: PWY-6803;Reactome: R-HSA-1482925;MetaCyc: PWY-7783	"Phospholipid remodeling (phosphatidate, yeast)";"Acyl chain remodelling of PS";"Acyl chain remodelling of PI";"Anandamide biosynthesis I";"Acyl chain remodelling of PC";"Ether lipid metabolism";"Synthesis of PA";"Arachidonic acid metabolism";"alpha-Linolenic acid metabolism";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Acyl chain remodelling of PE";"Anandamide biosynthesis II";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Linoleic acid metabolism";"Glycerophospholipid metabolism";"Phosphatidylcholine acyl editing";"Acyl chain remodelling of PG";"Plasmalogen degradation"
XP_046422797.1	7	MetaCyc: PWY-6724;MetaCyc: PWY-5941;Reactome: R-HSA-6798695;MetaCyc: PWY-7238;MetaCyc: PWY-6737;Reactome: R-HSA-70221;KEGG: 00500+2.4.1.25	"Starch degradation II";"Glycogen degradation II";"Neutrophil degranulation";"Sucrose biosynthesis II";"Starch degradation V";"Glycogen breakdown (glycogenolysis)";"Starch and sucrose metabolism"
XP_046427161.1	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
XP_046429122.1	2	Reactome: R-HSA-72163;Reactome: R-HSA-6807505	"mRNA Splicing - Major Pathway";"RNA polymerase II transcribes snRNA genes"
XP_046414136.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_046415778.1	2	Reactome: R-HSA-8866907;Reactome: R-HSA-8866904	"Activation of the TFAP2 (AP-2) family of transcription factors";"Negative regulation of activity of TFAP2 (AP-2) family transcription factors"
XP_046416144.1	10	MetaCyc: PWY-7587;MetaCyc: PWY-7411;Reactome: R-HSA-1483166;MetaCyc: PWY-5667;KEGG: 00564+2.3.1.15;KEGG: 00561+2.3.1.15;MetaCyc: PWY-8055;MetaCyc: PWY-8051;MetaCyc: PWY-6453;MetaCyc: PWY-8053	"Oleate biosynthesis III (cyanobacteria)";"Phosphatidate biosynthesis (yeast)";"Synthesis of PA";"CDP-diacylglycerol biosynthesis I";"Glycerophospholipid metabolism";"Glycerolipid metabolism";"Palmitoyl ethanolamide biosynthesis";"Anandamide biosynthesis I";"Stigma estolide biosynthesis";"Anandamide biosynthesis II"
XP_046427174.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046412855.1	2	KEGG: 00230+2.7.4.8;MetaCyc: PWY-7221	"Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis"
XP_046413044.1	3	Reactome: R-HSA-3000157;Reactome: R-HSA-8874081;Reactome: R-HSA-3000171	"Laminin interactions";"MET activates PTK2 signaling";"Non-integrin membrane-ECM interactions"
XP_046424640.1	6	MetaCyc: PWY-6807;KEGG: 00052+3.2.1.23;KEGG: 00604+3.2.1.23;KEGG: 00531+3.2.1.23;KEGG: 00511+3.2.1.23;KEGG: 00600+3.2.1.23	"Xyloglucan degradation II (exoglucanase)";"Galactose metabolism";"Glycosphingolipid biosynthesis - ganglio series";"Glycosaminoglycan degradation";"Other glycan degradation";"Sphingolipid metabolism"
XP_046414643.1	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
XP_046434905.1	30	Reactome: R-HSA-6782210;Reactome: R-HSA-113418;Reactome: R-HSA-167162;Reactome: R-HSA-6781823;Reactome: R-HSA-167246;Reactome: R-HSA-427413;Reactome: R-HSA-75953;Reactome: R-HSA-167160;Reactome: R-HSA-73762;Reactome: R-HSA-2564830;Reactome: R-HSA-6782135;Reactome: R-HSA-73779;Reactome: R-HSA-167158;Reactome: R-HSA-5696400;Reactome: R-HSA-6781827;Reactome: R-HSA-112382;Reactome: R-HSA-73863;Reactome: R-HSA-75955;Reactome: R-HSA-167172;Reactome: R-HSA-76042;Reactome: R-HSA-5696395;Reactome: R-HSA-167152;Reactome: R-HSA-167161;Reactome: R-HSA-73772;Reactome: R-HSA-77075;Reactome: R-HSA-167200;Reactome: R-HSA-6796648;Reactome: R-HSA-73776;Reactome: R-HSA-72086;Reactome: R-HSA-674695	"Gap-filling DNA repair synthesis and ligation in TC-NER";"Formation of the Early Elongation Complex";"RNA Polymerase II HIV Promoter Escape";"Formation of TC-NER Pre-Incision Complex";"Tat-mediated elongation of the HIV-1 transcript";"NoRC negatively regulates rRNA expression";"RNA Polymerase II Transcription Initiation";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"RNA Polymerase I Transcription Initiation";"Cytosolic iron-sulfur cluster assembly";"Dual incision in TC-NER";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Formation of the HIV-1 Early Elongation Complex";"Dual Incision in GG-NER";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Formation of RNA Pol II elongation complex";"RNA Polymerase I Transcription Termination";"RNA Polymerase II Transcription Elongation";"Transcription of the HIV genome";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Formation of Incision Complex in GG-NER";"Formation of HIV elongation complex in the absence of HIV Tat";"HIV Transcription Initiation";"RNA Polymerase I Promoter Escape";"RNA Pol II CTD phosphorylation and interaction with CE";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Promoter Escape";"mRNA Capping";"RNA Polymerase II Pre-transcription Events"
XP_046415819.1	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
XP_046428694.1	22	MetaCyc: PWY-7725;MetaCyc: PWY-7619;MetaCyc: PWY-5080;MetaCyc: PWY-8041;MetaCyc: PWY-7035;MetaCyc: PWY-7727;MetaCyc: PWY-6433;MetaCyc: PWY-7049;MetaCyc: PWY-6958;MetaCyc: PWY-5353;MetaCyc: PWY-7601;MetaCyc: PWY-7053;MetaCyc: PWY-7602;MetaCyc: PWY-6598;MetaCyc: PWY-7036;KEGG: 00062+4.2.1.134;MetaCyc: PWY-7726;Reactome: R-HSA-75876;MetaCyc: PWY-7724;MetaCyc: PWY-7728;MetaCyc: PWY-7606;MetaCyc: PWY-7592	"Arachidonate biosynthesis V (8-detaturase, mammals)";"Juniperonate biosynthesis";"Very long chain fatty acid biosynthesis I";"Ultra-long-chain fatty acid biosynthesis";"(9Z)-tricosene biosynthesis";"Docosahexaenoate biosynthesis IV (4-desaturase, mammals)";"Hydroxylated fatty acid biosynthesis (plants)";"Icosapentaenoate biosynthesis II (6-desaturase, mammals)";"Icosapentaenoate biosynthesis I (lower eukaryotes)";"Arachidonate biosynthesis I (6-desaturase, lower eukaryotes)";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Docosahexaenoate biosynthesis I (lower eukaryotes)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Sciadonate biosynthesis";"Very long chain fatty acid biosynthesis II";"Fatty acid elongation";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"Synthesis of very long-chain fatty acyl-CoAs";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Arachidonate biosynthesis III (6-desaturase, mammals)"
XP_046415427.1	6	Reactome: R-HSA-264642;Reactome: R-HSA-181430;Reactome: R-HSA-212676;Reactome: R-HSA-388844;Reactome: R-HSA-181429;Reactome: R-HSA-210500	"Acetylcholine Neurotransmitter Release Cycle";"Norepinephrine Neurotransmitter Release Cycle";"Dopamine Neurotransmitter Release Cycle";"Receptor-type tyrosine-protein phosphatases";"Serotonin Neurotransmitter Release Cycle";"Glutamate Neurotransmitter Release Cycle"
XP_046421668.1	3	Reactome: R-HSA-212436;Reactome: R-HSA-381340;Reactome: R-HSA-1989781	"Generic Transcription Pathway";"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression"
XP_046418450.1	2	Reactome: R-HSA-5687128;KEGG: 04150+2.7.11.24	"MAPK6/MAPK4 signaling";"mTOR signaling pathway"
XP_046425594.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046413187.1	2	KEGG: 00627+3.6.1.7;KEGG: 00620+3.6.1.7	"Aminobenzoate degradation";"Pyruvate metabolism"
XP_046421751.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_046425142.1	1	Reactome: R-HSA-1221632	"Meiotic synapsis"
XP_046420863.1	33	Reactome: R-HSA-5663220;Reactome: R-HSA-159227;Reactome: R-HSA-168333;Reactome: R-HSA-3301854;Reactome: R-HSA-5578749;Reactome: R-HSA-180746;Reactome: R-HSA-68877;Reactome: R-HSA-170822;Reactome: R-HSA-180910;Reactome: R-HSA-165054;Reactome: R-HSA-6784531;Reactome: R-HSA-4085377;Reactome: R-HSA-4570464;Reactome: R-HSA-141444;Reactome: R-HSA-159236;Reactome: R-HSA-9609690;Reactome: R-HSA-168325;Reactome: R-HSA-168271;Reactome: R-HSA-168276;Reactome: R-HSA-5619107;Reactome: R-HSA-159230;Reactome: R-HSA-191859;Reactome: R-HSA-4615885;Reactome: R-HSA-3232142;Reactome: R-HSA-2500257;Reactome: R-HSA-3371453;Reactome: R-HSA-4551638;Reactome: R-HSA-9610379;Reactome: R-HSA-9648025;Reactome: R-HSA-3108214;Reactome: R-HSA-159231;Reactome: R-HSA-1169408;Reactome: R-HSA-2467813	"RHO GTPases Activate Formins";"Transport of the SLBP independent Mature mRNA";"NEP/NS2 Interacts with the Cellular Export Machinery";"Nuclear Pore Complex (NPC) Disassembly";"Transcriptional regulation by small RNAs";"Nuclear import of Rev protein";"Mitotic Prometaphase";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Vpr-mediated nuclear import of PICs";"Rev-mediated nuclear export of HIV RNA";"tRNA processing in the nucleus";"SUMOylation of SUMOylation proteins";"SUMOylation of RNA binding proteins";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"HCMV Early Events";"Viral Messenger RNA Synthesis";"Transport of Ribonucleoproteins into the Host Nucleus";"NS1 Mediated Effects on Host Pathways";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Transport of the SLBP Dependant Mature mRNA";"snRNP Assembly";"SUMOylation of DNA replication proteins";"SUMOylation of ubiquitinylation proteins";"Resolution of Sister Chromatid Cohesion";"Regulation of HSF1-mediated heat shock response";"SUMOylation of chromatin organization proteins";"HCMV Late Events";"EML4 and NUDC in mitotic spindle formation";"SUMOylation of DNA damage response and repair proteins";"Transport of Mature mRNA Derived from an Intronless Transcript";"ISG15 antiviral mechanism";"Separation of Sister Chromatids"
XP_046430949.1	1	Reactome: R-HSA-8854691	"Interleukin-20 family signaling"
XP_046433945.1	5	Reactome: R-HSA-72163;Reactome: R-HSA-6782210;Reactome: R-HSA-6782135;Reactome: R-HSA-6781823;Reactome: R-HSA-6781827	"mRNA Splicing - Major Pathway";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Dual incision in TC-NER";"Formation of TC-NER Pre-Incision Complex";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)"
XP_046419321.1	1	Reactome: R-HSA-5693565	"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"
XP_046423847.1	1	Reactome: R-HSA-71384	"Ethanol oxidation"
XP_046435156.1	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_046421167.1	9	MetaCyc: PWY-7411;MetaCyc: PWY-6118;Reactome: R-HSA-1483166;MetaCyc: PWY-7902;MetaCyc: PWY-5667;KEGG: 00564+1.1.1.8;KEGG: 00564+1.1.1.94;MetaCyc: PWY-7385;MetaCyc: PWY-5981	"Phosphatidate biosynthesis (yeast)";"Glycerol-3-phosphate shuttle";"Synthesis of PA";"Glucosylglycerol biosynthesis";"CDP-diacylglycerol biosynthesis I";"Glycerophospholipid metabolism";"Glycerophospholipid metabolism";"1,3-propanediol biosynthesis (engineered)";"CDP-diacylglycerol biosynthesis III"
XP_046413491.1	11	KEGG: 00230+4.6.1.1;Reactome: R-HSA-170670;Reactome: R-HSA-163615;Reactome: R-HSA-5610787;Reactome: R-HSA-432040;Reactome: R-HSA-418594;Reactome: R-HSA-418597;Reactome: R-HSA-170660;Reactome: R-HSA-418555;Reactome: R-HSA-164378;Reactome: R-HSA-163359	"Purine metabolism";"Adenylate cyclase inhibitory pathway";"PKA activation";"Hedgehog 'off' state";"Vasopressin regulates renal water homeostasis via Aquaporins";"G alpha (i) signalling events";"G alpha (z) signalling events";"Adenylate cyclase activating pathway";"G alpha (s) signalling events";"PKA activation in glucagon signalling";"Glucagon signaling in metabolic regulation"
XP_046432161.1	1	Reactome: R-HSA-390522	"Striated Muscle Contraction"
XP_046416113.1	5	Reactome: R-HSA-5693579;Reactome: R-HSA-5685942;Reactome: R-HSA-5693616;Reactome: R-HSA-5693554;Reactome: R-HSA-5693568	"Homologous DNA Pairing and Strand Exchange";"HDR through Homologous Recombination (HRR)";"Presynaptic phase of homologous DNA pairing and strand exchange";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Resolution of D-loop Structures through Holliday Junction Intermediates"
XP_046412434.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_046435371.1	2	Reactome: R-HSA-8856825;Reactome: R-HSA-8856828	"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis"
XP_046433832.1	1	Reactome: R-HSA-1474228	"Degradation of the extracellular matrix"
XP_046425053.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_046411471.1	8	Reactome: R-HSA-68877;Reactome: R-HSA-4615885;Reactome: R-HSA-2467813;Reactome: R-HSA-9648025;Reactome: R-HSA-141444;Reactome: R-HSA-165054;Reactome: R-HSA-5663220;Reactome: R-HSA-2500257	"Mitotic Prometaphase";"SUMOylation of DNA replication proteins";"Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Rev-mediated nuclear export of HIV RNA";"RHO GTPases Activate Formins";"Resolution of Sister Chromatid Cohesion"
XP_046416129.1	1	Reactome: R-HSA-6802952	"Signaling by BRAF and RAF fusions"
XP_046420507.1	1	Reactome: R-HSA-428359	"Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA"
XP_046421106.1	4	Reactome: R-HSA-389661;MetaCyc: PWY-6987;KEGG: 00785+2.3.1.181;MetaCyc: PWY-7382	"Glyoxylate metabolism and glycine degradation";"Lipoate biosynthesis and incorporation III (Bacillus)";"Lipoic acid metabolism";"Lipoate biosynthesis and incorporation IV (yeast)"
XP_046415234.1	4	Reactome: R-HSA-2500257;Reactome: R-HSA-2470946;Reactome: R-HSA-2467813;Reactome: R-HSA-2468052	"Resolution of Sister Chromatid Cohesion";"Cohesin Loading onto Chromatin";"Separation of Sister Chromatids";"Establishment of Sister Chromatid Cohesion"
XP_046424838.1	1	KEGG: 00450+1.8.1.9	"Selenocompound metabolism"
XP_046430066.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_046424936.1	1	Reactome: R-HSA-432720	"Lysosome Vesicle Biogenesis"
XP_046413669.1	6	MetaCyc: PWY-7656;KEGG: 00073+1.2.1.84;MetaCyc: PWY-6733;Reactome: R-HSA-9640463;MetaCyc: PWY-5884;MetaCyc: PWY-7782	"Spodoptera littoralis pheromone biosynthesis";"Cutin, suberine and wax biosynthesis";"Sporopollenin precursors biosynthesis";"Wax biosynthesis";"Wax esters biosynthesis I";"Plasmalogen biosynthesis"
XP_046432153.1	1	Reactome: R-HSA-390522	"Striated Muscle Contraction"
XP_046422852.1	1	Reactome: R-HSA-426048	"Arachidonate production from DAG"
XP_046427971.1	24	Reactome: R-HSA-442720;Reactome: R-HSA-180024;Reactome: R-HSA-163615;Reactome: R-HSA-5687128;Reactome: R-HSA-983231;Reactome: R-HSA-5610783;Reactome: R-HSA-5610785;Reactome: R-HSA-163358;Reactome: R-HSA-5621575;Reactome: R-HSA-163560;Reactome: R-HSA-392517;Reactome: R-HSA-164378;Reactome: R-HSA-5610787;Reactome: R-HSA-381676;Reactome: R-HSA-8963896;Reactome: R-HSA-111931;Reactome: R-HSA-432040;Reactome: R-HSA-5610780;Reactome: R-HSA-4420097;KEGG: 04150+2.7.11.11;Reactome: R-HSA-8853659;Reactome: R-HSA-9634600;Reactome: R-HSA-422356;Reactome: R-HSA-9010642	"CREB1 phosphorylation through the activation of Adenylate Cyclase";"DARPP-32 events";"PKA activation";"MAPK6/MAPK4 signaling";"Factors involved in megakaryocyte development and platelet production";"Degradation of GLI2 by the proteasome";"GLI3 is processed to GLI3R by the proteasome";"PKA-mediated phosphorylation of key metabolic factors";"CD209 (DC-SIGN) signaling";"Triglyceride catabolism";"Rap1 signalling";"PKA activation in glucagon signalling";"Hedgehog 'off' state";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"HDL assembly";"PKA-mediated phosphorylation of CREB";"Vasopressin regulates renal water homeostasis via Aquaporins";"Degradation of GLI1 by the proteasome";"VEGFA-VEGFR2 Pathway";"mTOR signaling pathway";"RET signaling";"Regulation of glycolysis by fructose 2,6-bisphosphate metabolism";"Regulation of insulin secretion";"ROBO receptors bind AKAP5"
XP_046429572.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_046436437.1	5	Reactome: R-HSA-2871796;KEGG: 04150+2.7.11.24;Reactome: R-HSA-450321;Reactome: R-HSA-2559580;Reactome: R-HSA-450341	"FCERI mediated MAPK activation";"mTOR signaling pathway";"JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1";"Oxidative Stress Induced Senescence";"Activation of the AP-1 family of transcription factors"
XP_046427918.1	4	Reactome: R-HSA-379726;KEGG: 00970+6.1.1.17;MetaCyc: PWY-5188;KEGG: 00860+6.1.1.17	"Mitochondrial tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis";"Tetrapyrrole biosynthesis I (from glutamate)";"Porphyrin and chlorophyll metabolism"
XP_046413907.1	13	KEGG: 00562+3.1.4.11;Reactome: R-HSA-202433;Reactome: R-HSA-2871809;Reactome: R-HSA-2424491;MetaCyc: PWY-7039;MetaCyc: PWY-6351;MetaCyc: PWY-8052;MetaCyc: PWY-6367;KEGG: 04070+3.1.4.11;Reactome: R-HSA-2029485;Reactome: R-HSA-9027277;Reactome: R-HSA-1855204;Reactome: R-HSA-2871796	"Inositol phosphate metabolism";"Generation of second messenger molecules";"FCERI mediated Ca+2 mobilization";"DAP12 signaling";"Phosphatidate metabolism, as a signaling molecule";"D-myo-inositol (1,4,5)-trisphosphate biosynthesis";"2-arachidonoylglycerol biosynthesis";"D-myo-inositol-5-phosphate metabolism";"Phosphatidylinositol signaling system";"Role of phospholipids in phagocytosis";"Erythropoietin activates Phospholipase C gamma (PLCG)";"Synthesis of IP3 and IP4 in the cytosol";"FCERI mediated MAPK activation"
XP_046428097.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_046424098.1	12	Reactome: R-HSA-1169408;Reactome: R-HSA-975957;Reactome: R-HSA-72649;Reactome: R-HSA-72702;Reactome: R-HSA-975956;Reactome: R-HSA-166208;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-72662;Reactome: R-HSA-429947;Reactome: R-HSA-450408;Reactome: R-HSA-72706	"ISG15 antiviral mechanism";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Translation initiation complex formation";"Ribosomal scanning and start codon recognition";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"mTORC1-mediated signalling";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S";"Deadenylation of mRNA";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"GTP hydrolysis and joining of the 60S ribosomal subunit"
XP_046411125.1	1	Reactome: R-HSA-420029	"Tight junction interactions"
XP_046416917.1	14	MetaCyc: PWY-6803;Reactome: R-HSA-1482788;KEGG: 00565+3.1.1.4;KEGG: 00564+3.1.1.4+3.1.1.5;MetaCyc: PWY-8051;MetaCyc: PWY-7783;KEGG: 00592+3.1.1.4;Reactome: R-HSA-975634;KEGG: 00590+3.1.1.4;MetaCyc: PWY-8053;MetaCyc: PWY-7416;MetaCyc: PWY-7409;MetaCyc: PWY-7417;KEGG: 00591+3.1.1.4	"Phosphatidylcholine acyl editing";"Acyl chain remodelling of PC";"Ether lipid metabolism";"Glycerophospholipid metabolism";"Anandamide biosynthesis I";"Plasmalogen degradation";"alpha-Linolenic acid metabolism";"Retinoid metabolism and transport";"Arachidonic acid metabolism";"Anandamide biosynthesis II";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Phospholipid remodeling (phosphatidate, yeast)";"Linoleic acid metabolism"
XP_046415779.1	2	Reactome: R-HSA-8866904;Reactome: R-HSA-8866907	"Negative regulation of activity of TFAP2 (AP-2) family transcription factors";"Activation of the TFAP2 (AP-2) family of transcription factors"
XP_046435022.1	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286	"Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation"
XP_046421625.1	3	Reactome: R-HSA-1855167;MetaCyc: PWY-6369;KEGG: 04070+2.7.4.24+2.7.4.21	"Synthesis of pyrophosphates in the cytosol";"Inositol diphosphates biosynthesis";"Phosphatidylinositol signaling system"
XP_046414470.1	2	KEGG: 00073+2.3.1.20;KEGG: 00561+2.3.1.20	"Cutin, suberine and wax biosynthesis";"Glycerolipid metabolism"
XP_046410871.1	6	Reactome: R-HSA-73856;Reactome: R-HSA-975957;Reactome: R-HSA-72163;Reactome: R-HSA-9010553;Reactome: R-HSA-159236;Reactome: R-HSA-72187	"RNA Polymerase II Transcription Termination";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"mRNA Splicing - Major Pathway";"Regulation of expression of SLITs and ROBOs";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"mRNA 3'-end processing"
XP_046431032.1	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
XP_046414165.1	1	Reactome: R-HSA-8849932	"Synaptic adhesion-like molecules"
XP_046415420.1	2	Reactome: R-HSA-5578998;Reactome: R-HSA-174403	"Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD)";"Glutathione synthesis and recycling"
XP_046415448.1	31	Reactome: R-HSA-2426168;MetaCyc: PWYG-321;MetaCyc: PWY-8049;MetaCyc: PWY-8012;Reactome: R-HSA-199220;KEGG: 00780+1.1.1.100+4.2.1.59+2.3.1.41;MetaCyc: PWY-5367;MetaCyc: PWY-5142;MetaCyc: PWY-7664;MetaCyc: PWY-5966-1;MetaCyc: PWY-7388;MetaCyc: PWY-4381;MetaCyc: PWY-6799;MetaCyc: PWY-5994;MetaCyc: PWY-6113;MetaCyc: PWY-7663;MetaCyc: PWY-6519;MetaCyc: PWY-5971;Reactome: R-HSA-163765;MetaCyc: PWY-5366;KEGG: 00061+1.1.1.100+2.3.1.85+4.2.1.59+2.3.1.39+2.3.1.41+3.1.2.14;MetaCyc: PWY-8047;MetaCyc: PWY-5973;Reactome: R-HSA-75105;MetaCyc: PWY-6282;MetaCyc: PWY-7858;Reactome: R-HSA-9029558;MetaCyc: PWY-5147;MetaCyc: PWY-5989;MetaCyc: PWY-7723;MetaCyc: PWY-7746	"Activation of gene expression by SREBF (SREBP)";"";"Pederin biosynthesis";"Mupirocin biosynthesis";"Vitamin B5 (pantothenate) metabolism";"Biotin metabolism";"Petroselinate biosynthesis";"Acyl-[acyl-carrier protein] thioesterase pathway";"Oleate biosynthesis IV (anaerobic)";"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)";"Octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast)";"Fatty acid biosynthesis initiation (bacteria and plants)";"Fatty acid biosynthesis initiation (plant mitochondria)";"Palmitate biosynthesis (animals and fungi, cytoplasm)";"Superpathway of mycolate biosynthesis";"Gondoate biosynthesis (anaerobic)";"8-amino-7-oxononanoate biosynthesis I";"Palmitate biosynthesis II (bacteria and plant cytoplasm)";"ChREBP activates metabolic gene expression";"Palmitoleate biosynthesis II (plants and bacteria)";"Fatty acid biosynthesis";"Bryostatin biosynthesis";"Cis-vaccenate biosynthesis";"Fatty acyl-CoA biosynthesis";"Palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate)";"(5Z)-dodecenoate biosynthesis II";"NR1H2 & NR1H3 regulate gene expression linked to lipogenesis";"Oleate biosynthesis I (plants)";"Stearate biosynthesis II (bacteria and plants)";"Bacterial bioluminescence";"Mycobacterial sulfolipid biosynthesis"
XP_046433723.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_046416444.1	4	Reactome: R-HSA-6781823;Reactome: R-HSA-8951664;Reactome: R-HSA-5696394;Reactome: R-HSA-8856825	"Formation of TC-NER Pre-Incision Complex";"Neddylation";"DNA Damage Recognition in GG-NER";"Cargo recognition for clathrin-mediated endocytosis"
XP_046410310.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_046415450.1	31	MetaCyc: PWY-6113;MetaCyc: PWY-5994;Reactome: R-HSA-163765;MetaCyc: PWY-5971;MetaCyc: PWY-6519;MetaCyc: PWY-7663;MetaCyc: PWY-6282;Reactome: R-HSA-75105;MetaCyc: PWY-5973;KEGG: 00061+1.1.1.100+2.3.1.85+4.2.1.59+2.3.1.39+2.3.1.41+3.1.2.14;MetaCyc: PWY-8047;MetaCyc: PWY-5147;MetaCyc: PWY-5989;MetaCyc: PWY-7723;MetaCyc: PWY-7746;Reactome: R-HSA-9029558;MetaCyc: PWY-7858;MetaCyc: PWY-5366;MetaCyc: PWY-5367;KEGG: 00780+1.1.1.100+4.2.1.59+2.3.1.41;MetaCyc: PWY-7664;MetaCyc: PWY-5142;Reactome: R-HSA-2426168;Reactome: R-HSA-199220;MetaCyc: PWYG-321;MetaCyc: PWY-8012;MetaCyc: PWY-8049;MetaCyc: PWY-4381;MetaCyc: PWY-6799;MetaCyc: PWY-5966-1;MetaCyc: PWY-7388	"Superpathway of mycolate biosynthesis";"Palmitate biosynthesis (animals and fungi, cytoplasm)";"ChREBP activates metabolic gene expression";"Palmitate biosynthesis II (bacteria and plant cytoplasm)";"8-amino-7-oxononanoate biosynthesis I";"Gondoate biosynthesis (anaerobic)";"Palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate)";"Fatty acyl-CoA biosynthesis";"Cis-vaccenate biosynthesis";"Fatty acid biosynthesis";"Bryostatin biosynthesis";"Oleate biosynthesis I (plants)";"Stearate biosynthesis II (bacteria and plants)";"Bacterial bioluminescence";"Mycobacterial sulfolipid biosynthesis";"NR1H2 & NR1H3 regulate gene expression linked to lipogenesis";"(5Z)-dodecenoate biosynthesis II";"Palmitoleate biosynthesis II (plants and bacteria)";"Petroselinate biosynthesis";"Biotin metabolism";"Oleate biosynthesis IV (anaerobic)";"Acyl-[acyl-carrier protein] thioesterase pathway";"Activation of gene expression by SREBF (SREBP)";"Vitamin B5 (pantothenate) metabolism";"";"Mupirocin biosynthesis";"Pederin biosynthesis";"Fatty acid biosynthesis initiation (bacteria and plants)";"Fatty acid biosynthesis initiation (plant mitochondria)";"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)";"Octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast)"
XP_046435212.1	1	Reactome: R-HSA-72165	"mRNA Splicing - Minor Pathway"
XP_046436334.1	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
XP_046417741.1	2	Reactome: R-HSA-416993;Reactome: R-HSA-202733	"Trafficking of GluR2-containing AMPA receptors";"Cell surface interactions at the vascular wall"
XP_046415849.1	2	Reactome: R-HSA-204174;Reactome: R-HSA-5362517	"Regulation of pyruvate dehydrogenase (PDH) complex";"Signaling by Retinoic Acid"
XP_046410703.1	3	Reactome: R-HSA-6782315;MetaCyc: PWY-8106;MetaCyc: PWY-6700	"tRNA modification in the nucleus and cytosol";"Queuosine biosynthesis III (queuosine salvage)";"Queuosine biosynthesis I (de novo)"
XP_046430478.1	4	Reactome: R-HSA-201722;Reactome: R-HSA-2122947;Reactome: R-HSA-4641265;Reactome: R-HSA-3769402	"Formation of the beta-catenin:TCF transactivating complex";"NOTCH1 Intracellular Domain Regulates Transcription";"Repression of WNT target genes";"Deactivation of the beta-catenin transactivating complex"
XP_046411683.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_046427633.1	1	Reactome: R-HSA-6807878	"COPI-mediated anterograde transport"
XP_046427669.1	29	Reactome: R-HSA-167161;Reactome: R-HSA-5696395;Reactome: R-HSA-167152;Reactome: R-HSA-73772;Reactome: R-HSA-167200;Reactome: R-HSA-6796648;Reactome: R-HSA-77075;Reactome: R-HSA-73776;Reactome: R-HSA-72086;Reactome: R-HSA-674695;Reactome: R-HSA-73863;Reactome: R-HSA-112382;Reactome: R-HSA-75955;Reactome: R-HSA-167172;Reactome: R-HSA-76042;Reactome: R-HSA-167160;Reactome: R-HSA-73762;Reactome: R-HSA-6782135;Reactome: R-HSA-73779;Reactome: R-HSA-167158;Reactome: R-HSA-5696400;Reactome: R-HSA-6781827;Reactome: R-HSA-113418;Reactome: R-HSA-6782210;Reactome: R-HSA-167162;Reactome: R-HSA-6781823;Reactome: R-HSA-167246;Reactome: R-HSA-75953;Reactome: R-HSA-427413	"HIV Transcription Initiation";"Formation of Incision Complex in GG-NER";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Polymerase I Promoter Escape";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Pol II CTD phosphorylation and interaction with CE";"RNA Polymerase II Promoter Escape";"mRNA Capping";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase I Transcription Termination";"Formation of RNA Pol II elongation complex";"RNA Polymerase II Transcription Elongation";"Transcription of the HIV genome";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"RNA Polymerase I Transcription Initiation";"Dual incision in TC-NER";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Formation of the HIV-1 Early Elongation Complex";"Dual Incision in GG-NER";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Formation of the Early Elongation Complex";"Gap-filling DNA repair synthesis and ligation in TC-NER";"RNA Polymerase II HIV Promoter Escape";"Formation of TC-NER Pre-Incision Complex";"Tat-mediated elongation of the HIV-1 transcript";"RNA Polymerase II Transcription Initiation";"NoRC negatively regulates rRNA expression"
XP_046419806.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046431712.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046411753.1	1	KEGG: 00480+3.4.11.2	"Glutathione metabolism"
XP_046416630.1	7	Reactome: R-HSA-4086400;Reactome: R-HSA-201681;Reactome: R-HSA-201688;Reactome: R-HSA-5368598;Reactome: R-HSA-5663220;Reactome: R-HSA-4641258;Reactome: R-HSA-4641262	"PCP/CE pathway";"TCF dependent signaling in response to WNT";"WNT mediated activation of DVL";"Negative regulation of TCF-dependent signaling by DVL-interacting proteins";"RHO GTPases Activate Formins";"Degradation of DVL";"Disassembly of the destruction complex and recruitment of AXIN to the membrane"
XP_046414626.1	4	Reactome: R-HSA-350054;Reactome: R-HSA-2894862;Reactome: R-HSA-2122947;Reactome: R-HSA-2644606	"Notch-HLH transcription pathway";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"NOTCH1 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 PEST Domain Mutants"
XP_046435334.1	3	MetaCyc: PWY-6348;KEGG: 00740+3.1.3.2;KEGG: 00730+3.1.3.2	"Phosphate acquisition";"Riboflavin metabolism";"Thiamine metabolism"
XP_046425064.1	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
XP_046435575.1	1	Reactome: R-HSA-2028269	"Signaling by Hippo"
XP_046422039.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046427791.1	10	MetaCyc: PWY-5826;MetaCyc: PWY-6842;MetaCyc: PWY-7559;KEGG: 00480+2.3.2.2+3.4.19.13;KEGG: 00430+2.3.2.2;MetaCyc: PWY-7112;MetaCyc: PWY-4061;KEGG: 00460+2.3.2.2;MetaCyc: PWY-4041;MetaCyc: PWY-8001	"Hypoglycin biosynthesis";"Glutathione-mediated detoxification II";"Glutathione degradation (DUG pathway";"Glutathione metabolism";"Taurine and hypotaurine metabolism";"4-hydroxy-2-nonenal detoxification";"Glutathione-mediated detoxification I";"Cyanoamino acid metabolism";"Gamma-glutamyl cycle";"Felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis"
XP_046423426.1	11	Reactome: R-HSA-512988;Reactome: R-HSA-877312;Reactome: R-HSA-210990;Reactome: R-HSA-388841;Reactome: R-HSA-391160;Reactome: R-HSA-912694;Reactome: R-HSA-389948;Reactome: R-HSA-114604;Reactome: R-HSA-432142;Reactome: R-HSA-909733;Reactome: R-HSA-9008059	"Interleukin-3, Interleukin-5 and GM-CSF signaling";"Regulation of IFNG signaling";"PECAM1 interactions";"Costimulation by the CD28 family";"Signal regulatory protein family interactions";"Regulation of IFNA signaling";"PD-1 signaling";"GPVI-mediated activation cascade";"Platelet sensitization by LDL";"Interferon alpha/beta signaling";"Interleukin-37 signaling"
XP_046421035.1	2	Reactome: R-HSA-418890;Reactome: R-HSA-3295583	"Role of second messengers in netrin-1 signaling";"TRP channels"
XP_046417619.1	2	Reactome: R-HSA-416476;Reactome: R-HSA-375281	"G alpha (q) signalling events";"Hormone ligand-binding receptors"
XP_046430162.1	12	MetaCyc: PWY-5871;MetaCyc: PWY-6978;MetaCyc: PWY-5873;Reactome: R-HSA-2142789;MetaCyc: PWY-5872;Reactome: R-HSA-1268020;KEGG: 00130+2.5.1.39;MetaCyc: PWY-5856;MetaCyc: PWY-5870;MetaCyc: PWY-5855;MetaCyc: PWY-5857;MetaCyc: PWY-6708	"Ubiquinol-9 biosynthesis (eukaryotic)";"Plastoquinol-9 biosynthesis II";"Ubiquinol-7 biosynthesis (eukaryotic)";"Ubiquinol biosynthesis";"Ubiquinol-10 biosynthesis (eukaryotic)";"Mitochondrial protein import";"Ubiquinone and other terpenoid-quinone biosynthesis";"Ubiquinol-9 biosynthesis (prokaryotic)";"Ubiquinol-8 biosynthesis (eukaryotic)";"Ubiquinol-7 biosynthesis (prokaryotic)";"Ubiquinol-10 biosynthesis (prokaryotic)";"Ubiquinol-8 biosynthesis (prokaryotic)"
XP_046414747.1	1	Reactome: R-HSA-425986	"Sodium/Proton exchangers"
XP_046426293.1	2	Reactome: R-HSA-749476;Reactome: R-HSA-73980	"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Termination"
XP_046422461.1	2	Reactome: R-HSA-388479;Reactome: R-HSA-416476	"Vasopressin-like receptors";"G alpha (q) signalling events"
XP_046419146.1	2	Reactome: R-HSA-3214858;Reactome: R-HSA-8939243	"RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"
XP_046426296.1	2	Reactome: R-HSA-749476;Reactome: R-HSA-73980	"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Termination"
XP_046428715.1	6	MetaCyc: PWY-7817;MetaCyc: PWY-7039;KEGG: 00561+2.7.1.107;KEGG: 04070+2.7.1.107;Reactome: R-HSA-114508;KEGG: 00564+2.7.1.107	"Type I lipoteichoic acid biosynthesis (S. aureus)";"Phosphatidate metabolism, as a signaling molecule";"Glycerolipid metabolism";"Phosphatidylinositol signaling system";"Effects of PIP2 hydrolysis";"Glycerophospholipid metabolism"
XP_046426589.1	2	KEGG: 00561+2.7.1.30;MetaCyc: PWY-4261	"Glycerolipid metabolism";"Glycerol degradation I"
XP_046410645.1	1	Reactome: R-HSA-8949664	"Processing of SMDT1"
XP_046416530.1	5	Reactome: R-HSA-5693565;Reactome: R-HSA-5693607;Reactome: R-HSA-5689901;Reactome: R-HSA-5693571;Reactome: R-HSA-69473	"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Processing of DNA double-strand break ends";"Metalloprotease DUBs";"Nonhomologous End-Joining (NHEJ)";"G2/M DNA damage checkpoint"
XP_046413855.1	2	Reactome: R-HSA-373080;Reactome: R-HSA-3238698	"Class B/2 (Secretin family receptors)";"WNT ligand biogenesis and trafficking"
XP_046412223.1	4	Reactome: R-HSA-5656169;Reactome: R-HSA-5656121;Reactome: R-HSA-110312;Reactome: R-HSA-5655862	"Termination of translesion DNA synthesis";"Translesion synthesis by POLI";"Translesion synthesis by REV1";"Translesion synthesis by POLK"
XP_046432222.1	5	Reactome: R-HSA-75955;Reactome: R-HSA-674695;Reactome: R-HSA-201722;Reactome: R-HSA-112382;Reactome: R-HSA-8866654	"RNA Polymerase II Transcription Elongation";"RNA Polymerase II Pre-transcription Events";"Formation of the beta-catenin:TCF transactivating complex";"Formation of RNA Pol II elongation complex";"E3 ubiquitin ligases ubiquitinate target proteins"
XP_046426219.1	1	Reactome: R-HSA-6803157	"Antimicrobial peptides"
XP_046412535.1	2	Reactome: R-HSA-5205685;Reactome: R-HSA-983231	"Pink/Parkin Mediated Mitophagy";"Factors involved in megakaryocyte development and platelet production"
XP_046411190.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_046430525.1	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046436731.1	1	Reactome: R-HSA-8949613	"Cristae formation"
XP_046419318.1	1	Reactome: R-HSA-2132295	"MHC class II antigen presentation"
XP_046422762.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_046423657.1	1	Reactome: R-HSA-419037	"NCAM1 interactions"
XP_046412465.1	1	Reactome: R-HSA-110362	"POLB-Dependent Long Patch Base Excision Repair"
XP_046425265.1	4	MetaCyc: PWY-6963;KEGG: 00910+1.4.1.14;KEGG: 00250+1.4.1.14;Reactome: R-HSA-73621	"Ammonia assimilation cycle I";"Nitrogen metabolism";"Alanine, aspartate and glutamate metabolism";"Pyrimidine catabolism"
XP_046418336.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046414400.1	1	Reactome: R-HSA-71403	"Citric acid cycle (TCA cycle)"
XP_046428596.1	1	Reactome: R-HSA-75153	"Apoptotic execution phase"
XP_046416800.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046428180.1	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276	"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination"
XP_046432018.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_046432233.1	1	Reactome: R-HSA-6811440	"Retrograde transport at the Trans-Golgi-Network"
XP_046418396.1	1	Reactome: R-HSA-204005	"COPII-mediated vesicle transport"
XP_046424896.1	14	Reactome: R-HSA-380284;Reactome: R-HSA-68877;Reactome: R-HSA-380259;Reactome: R-HSA-6811436;Reactome: R-HSA-2467813;Reactome: R-HSA-2565942;Reactome: R-HSA-9648025;Reactome: R-HSA-380320;Reactome: R-HSA-141444;Reactome: R-HSA-5663220;Reactome: R-HSA-5620912;Reactome: R-HSA-2500257;Reactome: R-HSA-8854518;Reactome: R-HSA-380270	"Loss of proteins required for interphase microtubule organization from the centrosome";"Mitotic Prometaphase";"Loss of Nlp from mitotic centrosomes";"COPI-independent Golgi-to-ER retrograde traffic";"Separation of Sister Chromatids";"Regulation of PLK1 Activity at G2/M Transition";"EML4 and NUDC in mitotic spindle formation";"Recruitment of NuMA to mitotic centrosomes";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"RHO GTPases Activate Formins";"Anchoring of the basal body to the plasma membrane";"Resolution of Sister Chromatid Cohesion";"AURKA Activation by TPX2";"Recruitment of mitotic centrosome proteins and complexes"
XP_046410732.1	4	Reactome: R-HSA-112308;Reactome: R-HSA-5576893;Reactome: R-HSA-419037;Reactome: R-HSA-5576892	"Presynaptic depolarization and calcium channel opening";"Phase 2 - plateau phase";"NCAM1 interactions";"Phase 0 - rapid depolarisation"
XP_046428267.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046431746.1	4	KEGG: 00640+1.2.1.27;KEGG: 00280+1.2.1.27;MetaCyc: PWY-5642;Reactome: R-HSA-70895	"Propanoate metabolism";"Valine, leucine and isoleucine degradation";"2,4-dinitrotoluene degradation";"Branched-chain amino acid catabolism"
XP_046434764.1	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
XP_046410579.1	2	Reactome: R-HSA-418990;Reactome: R-HSA-5218920	"Adherens junctions interactions";"VEGFR2 mediated vascular permeability"
XP_046424979.1	2	Reactome: R-HSA-5205685;Reactome: R-HSA-1268020	"Pink/Parkin Mediated Mitophagy";"Mitochondrial protein import"
XP_046421044.1	5	MetaCyc: PWY-5084;KEGG: 00380+1.2.4.2;KEGG: 00310+1.2.4.2;Reactome: R-HSA-389661;KEGG: 00020+1.2.4.2	"2-oxoglutarate decarboxylation to succinyl-CoA";"Tryptophan metabolism";"Lysine degradation";"Glyoxylate metabolism and glycine degradation";"Citrate cycle (TCA cycle)"
XP_046419462.1	13	Reactome: R-HSA-9633012;Reactome: R-HSA-72689;Reactome: R-HSA-192823;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-2408557;Reactome: R-HSA-72706;Reactome: R-HSA-1799339;Reactome: R-HSA-975957;Reactome: R-HSA-6791226;Reactome: R-HSA-975956;Reactome: R-HSA-156902;Reactome: R-HSA-72764	"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Formation of a pool of free 40S subunits";"Viral mRNA Translation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Selenocysteine synthesis";"GTP hydrolysis and joining of the 60S ribosomal subunit";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Peptide chain elongation";"Eukaryotic Translation Termination"
XP_046430381.1	1	Reactome: R-HSA-3108214	"SUMOylation of DNA damage response and repair proteins"
XP_046432988.1	3	Reactome: R-HSA-1989781;Reactome: R-HSA-381340;Reactome: R-HSA-212436	"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation";"Generic Transcription Pathway"
XP_046421019.1	6	MetaCyc: PWY-7782;MetaCyc: PWY-5884;Reactome: R-HSA-9640463;MetaCyc: PWY-6733;MetaCyc: PWY-7656;KEGG: 00073+1.2.1.84	"Plasmalogen biosynthesis";"Wax esters biosynthesis I";"Wax biosynthesis";"Sporopollenin precursors biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Cutin, suberine and wax biosynthesis"
XP_046422703.1	18	KEGG: 00564+3.1.1.4;KEGG: 00591+3.1.1.4;MetaCyc: PWY-8053;Reactome: R-HSA-1482839;MetaCyc: PWY-7416;MetaCyc: PWY-7409;MetaCyc: PWY-7783;MetaCyc: PWY-6803;Reactome: R-HSA-1482925;Reactome: R-HSA-1482801;MetaCyc: PWY-7417;KEGG: 00592+3.1.1.4;KEGG: 00590+3.1.1.4;Reactome: R-HSA-1483166;KEGG: 00565+3.1.1.4;Reactome: R-HSA-1482788;MetaCyc: PWY-8051;Reactome: R-HSA-1482922	"Glycerophospholipid metabolism";"Linoleic acid metabolism";"Anandamide biosynthesis II";"Acyl chain remodelling of PE";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Plasmalogen degradation";"Phosphatidylcholine acyl editing";"Acyl chain remodelling of PG";"Acyl chain remodelling of PS";"Phospholipid remodeling (phosphatidate, yeast)";"alpha-Linolenic acid metabolism";"Arachidonic acid metabolism";"Synthesis of PA";"Ether lipid metabolism";"Acyl chain remodelling of PC";"Anandamide biosynthesis I";"Acyl chain remodelling of PI"
XP_046427910.1	6	KEGG: 04070+2.7.1.107;KEGG: 00564+2.7.1.107;Reactome: R-HSA-114508;MetaCyc: PWY-7817;KEGG: 00561+2.7.1.107;MetaCyc: PWY-7039	"Phosphatidylinositol signaling system";"Glycerophospholipid metabolism";"Effects of PIP2 hydrolysis";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Glycerolipid metabolism";"Phosphatidate metabolism, as a signaling molecule"
XP_046417747.1	1	Reactome: R-HSA-201451	"Signaling by BMP"
XP_046421715.1	1	Reactome: R-HSA-425410	"Metal ion SLC transporters"
XP_046420365.1	3	Reactome: R-HSA-947581;KEGG: 00790+2.8.1.9;MetaCyc: PWY-5963	"Molybdenum cofactor biosynthesis";"Folate biosynthesis";"Thio-molybdenum cofactor biosynthesis"
XP_046410379.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_046415552.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046424475.1	6	KEGG: 00073+1.2.1.84;MetaCyc: PWY-7656;Reactome: R-HSA-9640463;MetaCyc: PWY-6733;MetaCyc: PWY-5884;MetaCyc: PWY-7782	"Cutin, suberine and wax biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Wax biosynthesis";"Sporopollenin precursors biosynthesis";"Wax esters biosynthesis I";"Plasmalogen biosynthesis"
XP_046429621.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_046419652.1	1	Reactome: R-HSA-5689880	"Ub-specific processing proteases"
XP_046422139.1	6	MetaCyc: PWY-5067;MetaCyc: PWY-7900;MetaCyc: PWY-622;Reactome: R-HSA-189085;KEGG: 00500+2.4.1.18;KEGG: 00500+3.2.1.1	"Glycogen biosynthesis II (from UDP-D-Glucose)";"Glycogen biosynthesis III (from alpha-maltose 1-phosphate)";"Starch biosynthesis";"Digestion of dietary carbohydrate";"Starch and sucrose metabolism";"Starch and sucrose metabolism"
XP_046419390.1	6	MetaCyc: PWY-5884;MetaCyc: PWY-7782;Reactome: R-HSA-9640463;MetaCyc: PWY-6733;MetaCyc: PWY-7656;KEGG: 00073+1.2.1.84	"Wax esters biosynthesis I";"Plasmalogen biosynthesis";"Wax biosynthesis";"Sporopollenin precursors biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Cutin, suberine and wax biosynthesis"
XP_046416829.1	14	MetaCyc: PWY-7409;MetaCyc: PWY-8053;MetaCyc: PWY-7416;KEGG: 00591+3.1.1.4;MetaCyc: PWY-7417;MetaCyc: PWY-8051;KEGG: 00564+3.1.1.4+3.1.1.5;KEGG: 00565+3.1.1.4;Reactome: R-HSA-1482788;MetaCyc: PWY-6803;KEGG: 00590+3.1.1.4;Reactome: R-HSA-975634;KEGG: 00592+3.1.1.4;MetaCyc: PWY-7783	"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Anandamide biosynthesis II";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Linoleic acid metabolism";"Phospholipid remodeling (phosphatidate, yeast)";"Anandamide biosynthesis I";"Glycerophospholipid metabolism";"Ether lipid metabolism";"Acyl chain remodelling of PC";"Phosphatidylcholine acyl editing";"Arachidonic acid metabolism";"Retinoid metabolism and transport";"alpha-Linolenic acid metabolism";"Plasmalogen degradation"
XP_046416794.1	6	Reactome: R-HSA-427413;Reactome: R-HSA-73762;Reactome: R-HSA-5250924;Reactome: R-HSA-427359;Reactome: R-HSA-73772;Reactome: R-HSA-73863	"NoRC negatively regulates rRNA expression";"RNA Polymerase I Transcription Initiation";"B-WICH complex positively regulates rRNA expression";"SIRT1 negatively regulates rRNA expression";"RNA Polymerase I Promoter Escape";"RNA Polymerase I Transcription Termination"
XP_046418262.1	29	KEGG: 05163+2.7.11.1;Reactome: R-HSA-69541;Reactome: R-HSA-6804760;Reactome: R-HSA-69473;KEGG: 04926+2.7.11.1;Reactome: R-HSA-5693571;Reactome: R-HSA-6804756;KEGG: 04151+2.7.11.1;Reactome: R-HSA-5693616;Reactome: R-HSA-6796648;KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;Reactome: R-HSA-6803207;KEGG: 05170+2.7.11.1;Reactome: R-HSA-5693565;Reactome: R-HSA-3371453;Reactome: R-HSA-5685938;Reactome: R-HSA-5693554;Reactome: R-HSA-6803204;Reactome: R-HSA-5693568;KEGG: 05165+2.7.11.1;Reactome: R-HSA-349425;Reactome: R-HSA-5693579;Reactome: R-HSA-2559586;Reactome: R-HSA-5693607;Reactome: R-HSA-912446;Reactome: R-HSA-5693548;Reactome: R-HSA-5685942;Reactome: R-HSA-6804757	"Human cytomegalovirus infection";"Stabilization of p53";"Regulation of TP53 Activity through Methylation";"G2/M DNA damage checkpoint";"Relaxin signaling pathway";"Nonhomologous End-Joining (NHEJ)";"Regulation of TP53 Activity through Phosphorylation";"PI3K-Akt signaling pathway";"Presynaptic phase of homologous DNA pairing and strand exchange";"TP53 Regulates Transcription of DNA Repair Genes";"mTOR signaling pathway";"Thermogenesis";"TP53 Regulates Transcription of Caspase Activators and Caspases";"Human immunodeficiency virus 1 infection";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Regulation of HSF1-mediated heat shock response";"HDR through Single Strand Annealing (SSA)";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"TP53 Regulates Transcription of Genes Involved in Cytochrome C Release";"Resolution of D-loop Structures through Holliday Junction Intermediates";"Human papillomavirus infection";"Autodegradation of the E3 ubiquitin ligase COP1";"Homologous DNA Pairing and Strand Exchange";"DNA Damage/Telomere Stress Induced Senescence";"Processing of DNA double-strand break ends";"Meiotic recombination";"Sensing of DNA Double Strand Breaks";"HDR through Homologous Recombination (HRR)";"Regulation of TP53 Degradation"
XP_046421217.1	7	Reactome: R-HSA-1855204;MetaCyc: PWY-6351;MetaCyc: PWY-7039;KEGG: 04070+3.1.4.11;MetaCyc: PWY-6367;MetaCyc: PWY-8052;KEGG: 00562+3.1.4.11	"Synthesis of IP3 and IP4 in the cytosol";"D-myo-inositol (1,4,5)-trisphosphate biosynthesis";"Phosphatidate metabolism, as a signaling molecule";"Phosphatidylinositol signaling system";"D-myo-inositol-5-phosphate metabolism";"2-arachidonoylglycerol biosynthesis";"Inositol phosphate metabolism"
XP_046425836.1	1	Reactome: R-HSA-196836	"Vitamin C (ascorbate) metabolism"
XP_046431415.1	3	KEGG: 00230+4.6.1.2;Reactome: R-HSA-445355;Reactome: R-HSA-392154	"Purine metabolism";"Smooth Muscle Contraction";"Nitric oxide stimulates guanylate cyclase"
XP_046436440.1	5	Reactome: R-HSA-2871796;KEGG: 04150+2.7.11.24;Reactome: R-HSA-450341;Reactome: R-HSA-450321;Reactome: R-HSA-2559580	"FCERI mediated MAPK activation";"mTOR signaling pathway";"Activation of the AP-1 family of transcription factors";"JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1";"Oxidative Stress Induced Senescence"
XP_046429425.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046420164.1	2	Reactome: R-HSA-1369062;Reactome: R-HSA-9603798	"ABC transporters in lipid homeostasis";"Class I peroxisomal membrane protein import"
XP_046409778.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_046424920.1	3	Reactome: R-HSA-6798695;Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Neutrophil degranulation";"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_046424334.1	4	Reactome: R-HSA-2243919;Reactome: R-HSA-2214320;Reactome: R-HSA-1474228;Reactome: R-HSA-1650814	"Crosslinking of collagen fibrils";"Anchoring fibril formation";"Degradation of the extracellular matrix";"Collagen biosynthesis and modifying enzymes"
XP_046419459.1	1	Reactome: R-HSA-2559584	"Formation of Senescence-Associated Heterochromatin Foci (SAHF)"
XP_046419649.1	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
XP_046419072.1	1	Reactome: R-HSA-5658442	"Regulation of RAS by GAPs"
XP_046428062.1	1	Reactome: R-HSA-201681	"TCF dependent signaling in response to WNT"
XP_046421389.1	3	Reactome: R-HSA-203615;KEGG: 00790+1.1.1.153;Reactome: R-HSA-1474151	"eNOS activation";"Folate biosynthesis";"Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation"
XP_046426218.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_046425261.1	2	Reactome: R-HSA-5696394;Reactome: R-HSA-5689603	"DNA Damage Recognition in GG-NER";"UCH proteinases"
XP_046424827.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046422481.1	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
XP_046420710.1	14	MetaCyc: PWY-5080;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7601;MetaCyc: PWY-7619;MetaCyc: PWY-7725;MetaCyc: PWY-7035;MetaCyc: PWY-8041;MetaCyc: PWY-6598;MetaCyc: PWY-7602;MetaCyc: PWY-7036;MetaCyc: PWY-6433;MetaCyc: PWY-7724;MetaCyc: PWY-5972;Reactome: R-HSA-75876	"Very long chain fatty acid biosynthesis I";"Fatty acid elongation";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Juniperonate biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"(9Z)-tricosene biosynthesis";"Ultra-long-chain fatty acid biosynthesis";"Sciadonate biosynthesis";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis II";"Hydroxylated fatty acid biosynthesis (plants)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Stearate biosynthesis I (animals)";"Synthesis of very long-chain fatty acyl-CoAs"
XP_046413373.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_046424947.1	5	Reactome: R-HSA-73863;Reactome: R-HSA-5250924;Reactome: R-HSA-73772;Reactome: R-HSA-73762;Reactome: R-HSA-427413	"RNA Polymerase I Transcription Termination";"B-WICH complex positively regulates rRNA expression";"RNA Polymerase I Promoter Escape";"RNA Polymerase I Transcription Initiation";"NoRC negatively regulates rRNA expression"
XP_046424758.1	8	Reactome: R-HSA-8953750;Reactome: R-HSA-111464;Reactome: R-HSA-111458;Reactome: R-HSA-6803207;Reactome: R-HSA-6798695;Reactome: R-HSA-9627069;Reactome: R-HSA-111459;Reactome: R-HSA-111463	"Transcriptional Regulation by E2F6";"SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes";"Formation of apoptosome";"TP53 Regulates Transcription of Caspase Activators and Caspases";"Neutrophil degranulation";"Regulation of the apoptosome activity";"Activation of caspases through apoptosome-mediated cleavage";"SMAC (DIABLO) binds to IAPs"
XP_046413883.1	5	KEGG: 00520+3.2.1.14;Reactome: R-HSA-189085;MetaCyc: PWY-6855;MetaCyc: PWY-6902;MetaCyc: PWY-7822	"Amino sugar and nucleotide sugar metabolism";"Digestion of dietary carbohydrate";"Chitin degradation I (archaea)";"Chitin degradation II (Vibrio)";"Chitin degradation III (Serratia)"
XP_046436406.1	3	MetaCyc: PWY-5996;MetaCyc: PWY-5987;Reactome: R-HSA-75105	"Oleate biosynthesis II (animals and fungi)";"Sorgoleone biosynthesis";"Fatty acyl-CoA biosynthesis"
XP_046431390.1	3	Reactome: R-HSA-6785470;Reactome: R-HSA-6787450;Reactome: R-HSA-8868766	"tRNA processing in the mitochondrion";"tRNA modification in the mitochondrion";"rRNA processing in the mitochondrion"
XP_046426039.1	1	Reactome: R-HSA-6784531	"tRNA processing in the nucleus"
XP_046420983.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_046419954.1	19	Reactome: R-HSA-6802946;Reactome: R-HSA-5673000;Reactome: R-HSA-9620244;Reactome: R-HSA-5673001;Reactome: R-HSA-3371571;Reactome: R-HSA-6802952;Reactome: R-HSA-9649948;Reactome: R-HSA-442982;Reactome: R-HSA-6802955;Reactome: R-HSA-5576892;Reactome: R-HSA-877300;Reactome: R-HSA-9617324;Reactome: R-HSA-438066;Reactome: R-HSA-111932;Reactome: R-HSA-9022692;Reactome: R-HSA-9609736;Reactome: R-HSA-399719;Reactome: R-HSA-5578775;Reactome: R-HSA-936837	"Signaling by moderate kinase activity BRAF mutants";"RAF activation";"Long-term potentiation";"RAF/MAP kinase cascade";"HSF1-dependent transactivation";"Signaling by BRAF and RAF fusions";"Signaling downstream of RAS mutants";"Ras activation upon Ca2+ influx through NMDA receptor";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"Phase 0 - rapid depolarisation";"Interferon gamma signaling";"Negative regulation of NMDA receptor-mediated neuronal transmission";"Unblocking of NMDA receptors, glutamate binding and activation";"CaMK IV-mediated phosphorylation of CREB";"Regulation of MECP2 expression and activity";"Assembly and cell surface presentation of NMDA receptors";"Trafficking of AMPA receptors";"Ion homeostasis";"Ion transport by P-type ATPases"
XP_046424066.1	11	Reactome: R-HSA-3560783;Reactome: R-HSA-3560801;Reactome: R-HSA-4420332;Reactome: R-HSA-3000170;Reactome: R-HSA-2024096;Reactome: R-HSA-3656237;Reactome: R-HSA-2022928;Reactome: R-HSA-1971475;Reactome: R-HSA-3656253;Reactome: R-HSA-202733;Reactome: R-HSA-975634	"Defective B4GALT7 causes EDS, progeroid type";"Defective B3GAT3 causes JDSSDHD";"Defective B3GALT6 causes EDSP2 and SEMDJL1";"Syndecan interactions";"HS-GAG degradation";"Defective EXT2 causes exostoses 2";"HS-GAG biosynthesis";"A tetrasaccharide linker sequence is required for GAG synthesis";"Defective EXT1 causes exostoses 1, TRPS2 and CHDS";"Cell surface interactions at the vascular wall";"Retinoid metabolism and transport"
XP_046411194.1	4	KEGG: 00270+4.2.1.22;KEGG: 00260+4.2.1.22;MetaCyc: PWY-801;Reactome: R-HSA-1614603	"Cysteine and methionine metabolism";"Glycine, serine and threonine metabolism";"Homocysteine and cysteine interconversion";"Cysteine formation from homocysteine"
XP_046418337.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046420817.1	5	Reactome: R-HSA-9633012;Reactome: R-HSA-8963693;KEGG: 00250+6.3.5.4;Reactome: R-HSA-9648895;Reactome: R-HSA-380994	"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Aspartate and asparagine metabolism";"Alanine, aspartate and glutamate metabolism";"Response of EIF2AK1 (HRI) to heme deficiency";"ATF4 activates genes in response to endoplasmic reticulum stress"
XP_046421637.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046421270.1	4	Reactome: R-HSA-69656;Reactome: R-HSA-69202;Reactome: R-HSA-1362277;Reactome: R-HSA-8953750	"Cyclin A:Cdk2-associated events at S phase entry";"Cyclin E associated events during G1/S transition";"Transcription of E2F targets under negative control by DREAM complex";"Transcriptional Regulation by E2F6"
XP_046418397.1	1	Reactome: R-HSA-204005	"COPII-mediated vesicle transport"
XP_046410456.1	17	Reactome: R-HSA-5685942;Reactome: R-HSA-5358606;Reactome: R-HSA-174437;Reactome: R-HSA-6782210;Reactome: R-HSA-5358565;Reactome: R-HSA-6782135;Reactome: R-HSA-5696400;Reactome: R-HSA-174417;Reactome: R-HSA-174414;Reactome: R-HSA-69183;Reactome: R-HSA-174411;Reactome: R-HSA-5651801;Reactome: R-HSA-69166;Reactome: R-HSA-69091;Reactome: R-HSA-5696397;Reactome: R-HSA-110314;Reactome: R-HSA-5656169	"HDR through Homologous Recombination (HRR)";"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"Removal of the Flap Intermediate from the C-strand";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"Dual incision in TC-NER";"Dual Incision in GG-NER";"Telomere C-strand (Lagging Strand) Synthesis";"Processive synthesis on the C-strand of the telomere";"Processive synthesis on the lagging strand";"Polymerase switching on the C-strand of the telomere";"PCNA-Dependent Long Patch Base Excision Repair";"Removal of the Flap Intermediate";"Polymerase switching";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Recognition of DNA damage by PCNA-containing replication complex";"Termination of translesion DNA synthesis"
XP_046434867.1	1	Reactome: R-HSA-1445148	"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
XP_046425001.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_046413513.1	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
XP_046421575.1	7	KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1	"Relaxin signaling pathway";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Human cytomegalovirus infection";"Thermogenesis";"PI3K-Akt signaling pathway";"mTOR signaling pathway"
XP_046414518.1	4	Reactome: R-HSA-72163;Reactome: R-HSA-72187;Reactome: R-HSA-159236;Reactome: R-HSA-73856	"mRNA Splicing - Major Pathway";"mRNA 3'-end processing";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"RNA Polymerase II Transcription Termination"
XP_046423341.1	2	Reactome: R-HSA-180024;KEGG: 00230+3.1.4.53	"DARPP-32 events";"Purine metabolism"
XP_046419418.1	1	Reactome: R-HSA-432722	"Golgi Associated Vesicle Biogenesis"
XP_046421746.1	3	Reactome: R-HSA-75955;Reactome: R-HSA-674695;Reactome: R-HSA-112382	"RNA Polymerase II Transcription Elongation";"RNA Polymerase II Pre-transcription Events";"Formation of RNA Pol II elongation complex"
XP_046423559.1	4	Reactome: R-HSA-72163;Reactome: R-HSA-72187;Reactome: R-HSA-77595;Reactome: R-HSA-73856	"mRNA Splicing - Major Pathway";"mRNA 3'-end processing";"Processing of Intronless Pre-mRNAs";"RNA Polymerase II Transcription Termination"
XP_046409404.1	3	Reactome: R-HSA-74259;Reactome: R-HSA-73621;Reactome: R-HSA-196807	"Purine catabolism";"Pyrimidine catabolism";"Nicotinate metabolism"
XP_046431710.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046413222.1	7	KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1	"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Human cytomegalovirus infection";"Thermogenesis";"Relaxin signaling pathway";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection"
XP_046421077.1	2	Reactome: R-HSA-72702;Reactome: R-HSA-72706	"Ribosomal scanning and start codon recognition";"GTP hydrolysis and joining of the 60S ribosomal subunit"
XP_046415455.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_046413046.1	2	Reactome: R-HSA-4090294;Reactome: R-HSA-383280	"SUMOylation of intracellular receptors";"Nuclear Receptor transcription pathway"
XP_046427204.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046411412.1	1	Reactome: R-HSA-420499	"Class C/3 (Metabotropic glutamate/pheromone receptors)"
XP_046410128.1	6	KEGG: 04070+3.1.3.66;Reactome: R-HSA-1660499;Reactome: R-HSA-1660516;Reactome: R-HSA-1855183;KEGG: 00562+3.1.3.66;MetaCyc: PWY-6368	"Phosphatidylinositol signaling system";"Synthesis of PIPs at the plasma membrane";"Synthesis of PIPs at the early endosome membrane";"Synthesis of IP2, IP, and Ins in the cytosol";"Inositol phosphate metabolism";"3-phosphoinositide degradation"
XP_046415774.1	1	Reactome: R-HSA-3295583	"TRP channels"
XP_046409470.1	5	Reactome: R-HSA-432722;Reactome: R-HSA-8856828;Reactome: R-HSA-6798695;Reactome: R-HSA-8856825;Reactome: R-HSA-6811440	"Golgi Associated Vesicle Biogenesis";"Clathrin-mediated endocytosis";"Neutrophil degranulation";"Cargo recognition for clathrin-mediated endocytosis";"Retrograde transport at the Trans-Golgi-Network"
XP_046412395.1	4	Reactome: R-HSA-110312;Reactome: R-HSA-5655862;Reactome: R-HSA-5656169;Reactome: R-HSA-5656121	"Translesion synthesis by REV1";"Translesion synthesis by POLK";"Termination of translesion DNA synthesis";"Translesion synthesis by POLI"
XP_046428350.1	2	Reactome: R-HSA-4641265;Reactome: R-HSA-5339700	"Repression of WNT target genes";"TCF7L2 mutants don't bind CTBP"
XP_046413470.1	9	Reactome: R-HSA-2151201;Reactome: R-HSA-2426168;Reactome: R-HSA-1368108;Reactome: R-HSA-381340;Reactome: R-HSA-5617472;Reactome: R-HSA-400253;Reactome: R-HSA-1368082;Reactome: R-HSA-400206;Reactome: R-HSA-1989781	"Transcriptional activation of mitochondrial biogenesis";"Activation of gene expression by SREBF (SREBP)";"BMAL1:CLOCK,NPAS2 activates circadian gene expression";"Transcriptional regulation of white adipocyte differentiation";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Circadian Clock";"RORA activates gene expression";"Regulation of lipid metabolism by PPARalpha";"PPARA activates gene expression"
XP_046428750.1	13	Reactome: R-HSA-156902;Reactome: R-HSA-975956;Reactome: R-HSA-72764;Reactome: R-HSA-975957;Reactome: R-HSA-6791226;Reactome: R-HSA-72706;Reactome: R-HSA-2408557;Reactome: R-HSA-1799339;Reactome: R-HSA-72689;Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-192823	"Peptide chain elongation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Selenocysteine synthesis";"SRP-dependent cotranslational protein targeting to membrane";"Formation of a pool of free 40S subunits";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Viral mRNA Translation"
XP_046422027.1	5	Reactome: R-HSA-5675221;KEGG: 05235+3.1.3.16;Reactome: R-HSA-112409;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16	"Negative regulation of MAPK pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"RAF-independent MAPK1/3 activation";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation"
XP_046431756.1	5	KEGG: 04150+2.7.11.24;Reactome: R-HSA-171007;Reactome: R-HSA-4420097;Reactome: R-HSA-168638;Reactome: R-HSA-376172	"mTOR signaling pathway";"p38MAPK events";"VEGFA-VEGFR2 Pathway";"NOD1/2 Signaling Pathway";"DSCAM interactions"
XP_046415678.1	1	Reactome: R-HSA-5576886	"Phase 4 - resting membrane potential"
XP_046416188.1	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
XP_046433955.1	2	Reactome: R-HSA-388479;Reactome: R-HSA-416476	"Vasopressin-like receptors";"G alpha (q) signalling events"
XP_046420422.1	4	Reactome: R-HSA-5693579;Reactome: R-HSA-5693554;Reactome: R-HSA-5685942;Reactome: R-HSA-5693568	"Homologous DNA Pairing and Strand Exchange";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"HDR through Homologous Recombination (HRR)";"Resolution of D-loop Structures through Holliday Junction Intermediates"
XP_046413496.1	11	Reactome: R-HSA-418594;Reactome: R-HSA-432040;Reactome: R-HSA-5610787;Reactome: R-HSA-163615;Reactome: R-HSA-170670;KEGG: 00230+4.6.1.1;Reactome: R-HSA-164378;Reactome: R-HSA-163359;Reactome: R-HSA-418555;Reactome: R-HSA-170660;Reactome: R-HSA-418597	"G alpha (i) signalling events";"Vasopressin regulates renal water homeostasis via Aquaporins";"Hedgehog 'off' state";"PKA activation";"Adenylate cyclase inhibitory pathway";"Purine metabolism";"PKA activation in glucagon signalling";"Glucagon signaling in metabolic regulation";"G alpha (s) signalling events";"Adenylate cyclase activating pathway";"G alpha (z) signalling events"
XP_046426953.1	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
XP_046431383.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046418840.1	5	Reactome: R-HSA-159231;Reactome: R-HSA-72163;Reactome: R-HSA-72187;Reactome: R-HSA-73856;Reactome: R-HSA-77595	"Transport of Mature mRNA Derived from an Intronless Transcript";"mRNA Splicing - Major Pathway";"mRNA 3'-end processing";"RNA Polymerase II Transcription Termination";"Processing of Intronless Pre-mRNAs"
XP_046409801.1	11	Reactome: R-HSA-5685938;Reactome: R-HSA-428890;Reactome: R-HSA-2029482;Reactome: R-HSA-8939236;Reactome: R-HSA-5663213;Reactome: R-HSA-983231;Reactome: R-HSA-8940973;Reactome: R-HSA-5693565;KEGG: 04660+2.7.10.2;Reactome: R-HSA-69231;Reactome: R-HSA-525793	"HDR through Single Strand Annealing (SSA)";"Role of ABL in ROBO-SLIT signaling";"Regulation of actin dynamics for phagocytic cup formation";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"RHO GTPases Activate WASPs and WAVEs";"Factors involved in megakaryocyte development and platelet production";"RUNX2 regulates osteoblast differentiation";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"T cell receptor signaling pathway";"Cyclin D associated events in G1";"Myogenesis"
XP_046417979.1	1	Reactome: R-HSA-71384	"Ethanol oxidation"
XP_046421669.1	2	Reactome: R-HSA-72165;Reactome: R-HSA-72163	"mRNA Splicing - Minor Pathway";"mRNA Splicing - Major Pathway"
XP_046416843.1	6	MetaCyc: PWY-5884;MetaCyc: PWY-7782;MetaCyc: PWY-6733;Reactome: R-HSA-9640463;MetaCyc: PWY-7656;KEGG: 00073+1.2.1.84	"Wax esters biosynthesis I";"Plasmalogen biosynthesis";"Sporopollenin precursors biosynthesis";"Wax biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Cutin, suberine and wax biosynthesis"
XP_046415295.1	5	Reactome: R-HSA-5696395;Reactome: R-HSA-6783310;Reactome: R-HSA-5685938;Reactome: R-HSA-5696400;Reactome: R-HSA-6782135	"Formation of Incision Complex in GG-NER";"Fanconi Anemia Pathway";"HDR through Single Strand Annealing (SSA)";"Dual Incision in GG-NER";"Dual incision in TC-NER"
XP_046433245.1	1	Reactome: R-HSA-3295583	"TRP channels"
XP_046412675.1	7	Reactome: R-HSA-2565942;Reactome: R-HSA-380270;Reactome: R-HSA-380320;Reactome: R-HSA-380259;Reactome: R-HSA-8854518;Reactome: R-HSA-5620912;Reactome: R-HSA-380284	"Regulation of PLK1 Activity at G2/M Transition";"Recruitment of mitotic centrosome proteins and complexes";"Recruitment of NuMA to mitotic centrosomes";"Loss of Nlp from mitotic centrosomes";"AURKA Activation by TPX2";"Anchoring of the basal body to the plasma membrane";"Loss of proteins required for interphase microtubule organization from the centrosome"
XP_046423485.1	3	Reactome: R-HSA-429947;Reactome: R-HSA-5617472;Reactome: R-HSA-6804115	"Deadenylation of mRNA";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"
XP_046420060.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046424413.1	3	Reactome: R-HSA-450385;Reactome: R-HSA-430039;Reactome: R-HSA-450513	"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"mRNA decay by 5' to 3' exoribonuclease";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA"
XP_046433525.1	1	Reactome: R-HSA-5620912	"Anchoring of the basal body to the plasma membrane"
XP_046415109.1	1	Reactome: R-HSA-162791	"Attachment of GPI anchor to uPAR"
XP_046431724.1	1	KEGG: 04150+2.7.11.24	"mTOR signaling pathway"
XP_046429530.1	2	Reactome: R-HSA-8876198;Reactome: R-HSA-5357905	"RAB GEFs exchange GTP for GDP on RABs";"Regulation of TNFR1 signaling"
XP_046425825.1	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
XP_046423328.1	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046422209.1	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
XP_046423941.1	14	MetaCyc: PWY-7724;Reactome: R-HSA-75876;MetaCyc: PWY-5972;MetaCyc: PWY-6433;MetaCyc: PWY-7035;MetaCyc: PWY-8041;MetaCyc: PWY-7602;MetaCyc: PWY-6598;MetaCyc: PWY-7036;MetaCyc: PWY-5080;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7601;MetaCyc: PWY-7619;MetaCyc: PWY-7725	"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Synthesis of very long-chain fatty acyl-CoAs";"Stearate biosynthesis I (animals)";"Hydroxylated fatty acid biosynthesis (plants)";"(9Z)-tricosene biosynthesis";"Ultra-long-chain fatty acid biosynthesis";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Sciadonate biosynthesis";"Very long chain fatty acid biosynthesis II";"Very long chain fatty acid biosynthesis I";"Fatty acid elongation";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Juniperonate biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)"
XP_046412867.1	26	Reactome: R-HSA-6804114;Reactome: R-HSA-5656169;Reactome: R-HSA-69091;Reactome: R-HSA-110314;Reactome: R-HSA-5696397;Reactome: R-HSA-5656121;Reactome: R-HSA-5655862;Reactome: R-HSA-5358565;Reactome: R-HSA-110320;Reactome: R-HSA-6782135;Reactome: R-HSA-5696400;Reactome: R-HSA-174414;Reactome: R-HSA-174411;Reactome: R-HSA-174417;Reactome: R-HSA-69183;Reactome: R-HSA-110312;Reactome: R-HSA-8866654;Reactome: R-HSA-5651801;Reactome: R-HSA-69166;Reactome: R-HSA-4615885;Reactome: R-HSA-5685942;Reactome: R-HSA-69205;Reactome: R-HSA-1362277;Reactome: R-HSA-174437;Reactome: R-HSA-5358606;Reactome: R-HSA-6782210	"TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest";"Termination of translesion DNA synthesis";"Polymerase switching";"Recognition of DNA damage by PCNA-containing replication complex";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Translesion synthesis by POLI";"Translesion synthesis by POLK";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"Translesion Synthesis by POLH";"Dual incision in TC-NER";"Dual Incision in GG-NER";"Processive synthesis on the C-strand of the telomere";"Polymerase switching on the C-strand of the telomere";"Telomere C-strand (Lagging Strand) Synthesis";"Processive synthesis on the lagging strand";"Translesion synthesis by REV1";"E3 ubiquitin ligases ubiquitinate target proteins";"PCNA-Dependent Long Patch Base Excision Repair";"Removal of the Flap Intermediate";"SUMOylation of DNA replication proteins";"HDR through Homologous Recombination (HRR)";"G1/S-Specific Transcription";"Transcription of E2F targets under negative control by DREAM complex";"Removal of the Flap Intermediate from the C-strand";"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"Gap-filling DNA repair synthesis and ligation in TC-NER"
XP_046415961.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046419067.1	4	Reactome: R-HSA-72731;MetaCyc: PWY-4361;MetaCyc: PWY-7174;KEGG: 00270+5.3.1.23	"Recycling of eIF2:GDP";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation II";"Cysteine and methionine metabolism"
XP_046419938.1	19	Reactome: R-HSA-5673001;Reactome: R-HSA-5673000;Reactome: R-HSA-6802946;Reactome: R-HSA-9620244;Reactome: R-HSA-6802955;Reactome: R-HSA-442982;Reactome: R-HSA-3371571;Reactome: R-HSA-9649948;Reactome: R-HSA-6802952;Reactome: R-HSA-438066;Reactome: R-HSA-111932;Reactome: R-HSA-9022692;Reactome: R-HSA-877300;Reactome: R-HSA-5576892;Reactome: R-HSA-9617324;Reactome: R-HSA-936837;Reactome: R-HSA-5578775;Reactome: R-HSA-399719;Reactome: R-HSA-9609736	"RAF/MAP kinase cascade";"RAF activation";"Signaling by moderate kinase activity BRAF mutants";"Long-term potentiation";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"Ras activation upon Ca2+ influx through NMDA receptor";"HSF1-dependent transactivation";"Signaling downstream of RAS mutants";"Signaling by BRAF and RAF fusions";"Unblocking of NMDA receptors, glutamate binding and activation";"CaMK IV-mediated phosphorylation of CREB";"Regulation of MECP2 expression and activity";"Interferon gamma signaling";"Phase 0 - rapid depolarisation";"Negative regulation of NMDA receptor-mediated neuronal transmission";"Ion transport by P-type ATPases";"Ion homeostasis";"Trafficking of AMPA receptors";"Assembly and cell surface presentation of NMDA receptors"
XP_046415651.1	3	Reactome: R-HSA-71262;MetaCyc: PWY-6100;KEGG: 00310+1.14.11.8	"Carnitine synthesis";"L-carnitine biosynthesis";"Lysine degradation"
XP_046431079.1	4	Reactome: R-HSA-3769402;Reactome: R-HSA-2122947;Reactome: R-HSA-201722;Reactome: R-HSA-4641265	"Deactivation of the beta-catenin transactivating complex";"NOTCH1 Intracellular Domain Regulates Transcription";"Formation of the beta-catenin:TCF transactivating complex";"Repression of WNT target genes"
XP_046421038.1	2	Reactome: R-HSA-418890;Reactome: R-HSA-3295583	"Role of second messengers in netrin-1 signaling";"TRP channels"
XP_046422276.1	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
XP_046419930.1	8	MetaCyc: PWY-7921;KEGG: 00514+2.4.1.109;MetaCyc: PWY-7922;Reactome: R-HSA-5083629;Reactome: R-HSA-5173105;KEGG: 00515+2.4.1.109;MetaCyc: PWY-7979;Reactome: R-HSA-5083633	"Protein O-mannosylation I (yeast)";"Other types of O-glycan biosynthesis";"Protein O-mannosylation II (mammals, core M1 and core M2)";"Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2";"O-linked glycosylation";"Mannose type O-glycan biosynthesis";"Protein O-mannosylation III (mammals, core M3)";"Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1"
XP_046424128.1	3	MetaCyc: PWY-7800;MetaCyc: PWY-7799;Reactome: R-HSA-2514859	"Ac/N-end rule pathway";"Arg/N-end rule pathway (eukaryotic)";"Inactivation, recovery and regulation of the phototransduction cascade"
XP_046410696.1	16	Reactome: R-HSA-179409;Reactome: R-HSA-176412;Reactome: R-HSA-174048;Reactome: R-HSA-8853884;Reactome: R-HSA-176409;Reactome: R-HSA-174084;Reactome: R-HSA-2467813;Reactome: R-HSA-174178;Reactome: R-HSA-2559582;Reactome: R-HSA-176407;Reactome: R-HSA-174184;Reactome: R-HSA-176408;Reactome: R-HSA-174154;Reactome: R-HSA-69017;Reactome: R-HSA-983168;Reactome: R-HSA-141430	"APC-Cdc20 mediated degradation of Nek2A";"Phosphorylation of the APC/C";"APC/C:Cdc20 mediated degradation of Cyclin B";"Transcriptional Regulation by VENTX";"APC/C:Cdc20 mediated degradation of mitotic proteins";"Autodegradation of Cdh1 by Cdh1:APC/C";"Separation of Sister Chromatids";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Senescence-Associated Secretory Phenotype (SASP)";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Regulation of APC/C activators between G1/S and early anaphase";"APC/C:Cdc20 mediated degradation of Securin";"CDK-mediated phosphorylation and removal of Cdc6";"Antigen processing: Ubiquitination & Proteasome degradation";"Inactivation of APC/C via direct inhibition of the APC/C complex"
XP_046427811.1	42	MetaCyc: PWY-7654;MetaCyc: PWY-5177;KEGG: 00623+1.1.1.35;KEGG: 00410+4.2.1.17;KEGG: 00720+4.2.1.17+1.1.1.35;KEGG: 00310+4.2.1.17+1.1.1.35;MetaCyc: PWY-7778;MetaCyc: PWY-5138;MetaCyc: PWY-7094;MetaCyc: PWY-5109;MetaCyc: PWY-6944;KEGG: 00360+4.2.1.17;KEGG: 00071+4.2.1.17+1.1.1.35;KEGG: 00627+4.2.1.17;MetaCyc: PWY-7216;MetaCyc: PWY-5789;KEGG: 00930+4.2.1.17+1.1.1.35;KEGG: 00903+4.2.1.17;KEGG: 00650+4.2.1.17+1.1.1.35;KEGG: 00062+4.2.1.17+1.1.1.35;MetaCyc: PWY-5136;MetaCyc: PWY-6863;KEGG: 00380+4.2.1.17+1.1.1.35;MetaCyc: PWY-1361;KEGG: 00592+4.2.1.17;KEGG: 00650+5.1.2.3+4.2.1.17+1.1.1.35;KEGG: 00281+4.2.1.17+1.1.1.35;KEGG: 00280+4.2.1.17+1.1.1.35;MetaCyc: PWY-7779;MetaCyc: PWY-6435;MetaCyc: PWY-6583;MetaCyc: PWY-7401;KEGG: 00071+5.1.2.3+4.2.1.17+1.1.1.35;KEGG: 00640+4.2.1.17;MetaCyc: PWY-7656;MetaCyc: PWY-6945;MetaCyc: PWY-6883;MetaCyc: PWY-7606;MetaCyc: PWY-6946;MetaCyc: PWY-7726;MetaCyc: PWY-7007;KEGG: 00362+4.2.1.17+1.1.1.35	"(8E,10E)-dodeca-8,10-dienol biosynthesis";"Glutaryl-coa degradation";"Toluene degradation";"beta-Alanine metabolism";"Carbon fixation pathways in prokaryotes";"Lysine degradation";"2-methylpropene degradation";"Fatty acid beta-oxidation IV (unsaturated, even number)";"Fatty acid salvage";"Fermentation to 2-methylbutanoate";"Androstenedione degradation";"Phenylalanine metabolism";"Fatty acid degradation";"Aminobenzoate degradation";"(R)- and (S)-3-hydroxybutanoate biosynthesis (engineered)";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Caprolactam degradation";"Limonene and pinene degradation";"Butanoate metabolism";"Fatty acid elongation";"Fatty acid beta-oxidation II (plant peroxisome)";"Pyruvate fermentation to hexanol (engineered)";"Tryptophan metabolism";"Benzoyl-coa degradation I (aerobic)";"alpha-Linolenic acid metabolism";"Butanoate metabolism";"Geraniol degradation";"Valine, leucine and isoleucine degradation";"Methyl tert-butyl ether degradation";"4-hydroxybenzoate biosynthesis III (plants)";"Pyruvate fermentation to butanol I";"Crotonate fermentation (to acetate and cyclohexane carboxylate)";"Fatty acid degradation";"Propanoate metabolism";"Spodoptera littoralis pheromone biosynthesis";"Cholesterol degradation to androstenedione I (cholesterol oxidase)";"Pyruvate fermentation to butanol II (engineered)";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Cholesterol degradation to androstenedione II (cholesterol dehydrogenase)";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"Methyl ketone biosynthesis (engineered)";"Benzoate degradation"
XP_046416570.1	1	Reactome: R-HSA-420499	"Class C/3 (Metabotropic glutamate/pheromone receptors)"
XP_046430938.1	1	Reactome: R-HSA-373753	"Nephrin family interactions"
XP_046435506.1	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
XP_046418548.1	16	Reactome: R-HSA-72695;Reactome: R-HSA-1799339;Reactome: R-HSA-72689;Reactome: R-HSA-192823;Reactome: R-HSA-156902;Reactome: R-HSA-72649;Reactome: R-HSA-72764;Reactome: R-HSA-975957;Reactome: R-HSA-72706;Reactome: R-HSA-2408557;Reactome: R-HSA-9633012;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-975956;Reactome: R-HSA-72702;Reactome: R-HSA-6791226	"Formation of the ternary complex, and subsequently, the 43S complex";"SRP-dependent cotranslational protein targeting to membrane";"Formation of a pool of free 40S subunits";"Viral mRNA Translation";"Peptide chain elongation";"Translation initiation complex formation";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Selenocysteine synthesis";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Ribosomal scanning and start codon recognition";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046432826.1	3	Reactome: R-HSA-1296072;Reactome: R-HSA-5576890;Reactome: R-HSA-5576893	"Voltage gated Potassium channels";"Phase 3 - rapid repolarisation";"Phase 2 - plateau phase"
XP_046418364.1	1	Reactome: R-HSA-6790901	"rRNA modification in the nucleus and cytosol"
XP_046410647.1	1	Reactome: R-HSA-8949664	"Processing of SMDT1"
XP_046427532.1	1	Reactome: R-HSA-1632852	"Macroautophagy"
XP_046426135.1	10	MetaCyc: PWY-4661;KEGG: 04070+2.7.1.158;MetaCyc: PWY-6372;MetaCyc: PWY-6369;MetaCyc: PWY-6554;KEGG: 00562+2.7.1.158;MetaCyc: PWY-6362;MetaCyc: PWY-6361;Reactome: R-HSA-1855167;Reactome: R-HSA-1855191	"1D-myo-inositol hexakisphosphate biosynthesis III (Spirodela polyrrhiza)";"Phosphatidylinositol signaling system";"1D-myo-inositol hexakisphosphate biosynthesis IV (Dictyostelium)";"Inositol diphosphates biosynthesis";"1D-myo-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3)";"Inositol phosphate metabolism";"1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)";"1D-myo-inositol hexakisphosphate biosynthesis I (from Ins(1,4,5)P3)";"Synthesis of pyrophosphates in the cytosol";"Synthesis of IPs in the nucleus"
XP_046414915.1	4	Reactome: R-HSA-2467813;Reactome: R-HSA-2468052;Reactome: R-HSA-2500257;Reactome: R-HSA-2470946	"Separation of Sister Chromatids";"Establishment of Sister Chromatid Cohesion";"Resolution of Sister Chromatid Cohesion";"Cohesin Loading onto Chromatin"
XP_046416985.1	2	Reactome: R-HSA-6811438;Reactome: R-HSA-6811440	"Intra-Golgi traffic";"Retrograde transport at the Trans-Golgi-Network"
XP_046414333.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046426426.1	9	Reactome: R-HSA-5689880;Reactome: R-HSA-9613829;Reactome: R-HSA-9615710;Reactome: R-HSA-8856825;Reactome: R-HSA-8856828;Reactome: R-HSA-5678895;Reactome: R-HSA-9646399;Reactome: R-HSA-5627083;Reactome: R-HSA-382556	"Ub-specific processing proteases";"Chaperone Mediated Autophagy";"Late endosomal microautophagy";"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis";"Defective CFTR causes cystic fibrosis";"Aggrephagy";"RHO GTPases regulate CFTR trafficking";"ABC-family proteins mediated transport"
XP_046413706.1	13	Reactome: R-HSA-975956;Reactome: R-HSA-156902;Reactome: R-HSA-72764;Reactome: R-HSA-975957;Reactome: R-HSA-6791226;Reactome: R-HSA-2408557;Reactome: R-HSA-72706;Reactome: R-HSA-1799339;Reactome: R-HSA-72689;Reactome: R-HSA-9633012;Reactome: R-HSA-192823;Reactome: R-HSA-9010553;Reactome: R-HSA-156827	"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Peptide chain elongation";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"Selenocysteine synthesis";"GTP hydrolysis and joining of the 60S ribosomal subunit";"SRP-dependent cotranslational protein targeting to membrane";"Formation of a pool of free 40S subunits";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression"
XP_046420794.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_046431742.1	9	KEGG: 00620+6.4.1.1;Reactome: R-HSA-3371599;KEGG: 00720+6.4.1.1;MetaCyc: PWY-6142;Reactome: R-HSA-70263;Reactome: R-HSA-196780;MetaCyc: PWY-6146;MetaCyc: PWY-8086;KEGG: 00020+6.4.1.1	"Pyruvate metabolism";"Defective HLCS causes multiple carboxylase deficiency";"Carbon fixation pathways in prokaryotes";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Gluconeogenesis";"Biotin transport and metabolism";"Methanobacterium thermoautotrophicum biosynthetic metabolism";"(S)-lactate fermentation to propanoate, acetate and hydrogen";"Citrate cycle (TCA cycle)"
XP_046422653.1	4	Reactome: R-HSA-72163;Reactome: R-HSA-72187;Reactome: R-HSA-159236;Reactome: R-HSA-73856	"mRNA Splicing - Major Pathway";"mRNA 3'-end processing";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"RNA Polymerase II Transcription Termination"
XP_046434969.1	3	Reactome: R-HSA-8876198;Reactome: R-HSA-6811440;Reactome: R-HSA-6811438	"RAB GEFs exchange GTP for GDP on RABs";"Retrograde transport at the Trans-Golgi-Network";"Intra-Golgi traffic"
XP_046434970.1	3	Reactome: R-HSA-6811438;Reactome: R-HSA-8876198;Reactome: R-HSA-6811440	"Intra-Golgi traffic";"RAB GEFs exchange GTP for GDP on RABs";"Retrograde transport at the Trans-Golgi-Network"
XP_046421136.1	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276	"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination"
XP_046422869.1	1	Reactome: R-HSA-6794361	"Neurexins and neuroligins"
XP_046423434.1	1	Reactome: R-HSA-2565942	"Regulation of PLK1 Activity at G2/M Transition"
XP_046430929.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_046423774.1	14	Reactome: R-HSA-205043;Reactome: R-HSA-3928665;Reactome: R-HSA-1474228;Reactome: R-HSA-2644606;Reactome: R-HSA-6798695;Reactome: R-HSA-2979096;Reactome: R-HSA-1251985;Reactome: R-HSA-9013507;Reactome: R-HSA-9017802;Reactome: R-HSA-193692;Reactome: R-HSA-977225;Reactome: R-HSA-2122948;Reactome: R-HSA-2894862;Reactome: R-HSA-9013700	"NRIF signals cell death from the nucleus";"EPH-ephrin mediated repulsion of cells";"Degradation of the extracellular matrix";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Neutrophil degranulation";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Nuclear signaling by ERBB4";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Noncanonical activation of NOTCH3";"Regulated proteolysis of p75NTR";"Amyloid fiber formation";"Activated NOTCH1 Transmits Signal to the Nucleus";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"NOTCH4 Activation and Transmission of Signal to the Nucleus"
XP_046428978.1	2	Reactome: R-HSA-8866654;Reactome: R-HSA-9033241	"E3 ubiquitin ligases ubiquitinate target proteins";"Peroxisomal protein import"
XP_046413379.1	3	Reactome: R-HSA-73843;KEGG: 00230+2.7.6.1;KEGG: 00030+2.7.6.1	"5-Phosphoribose 1-diphosphate biosynthesis";"Purine metabolism";"Pentose phosphate pathway"
XP_046420927.1	1	Reactome: R-HSA-201681	"TCF dependent signaling in response to WNT"
XP_046433939.1	5	Reactome: R-HSA-6781823;Reactome: R-HSA-6782135;Reactome: R-HSA-6781827;Reactome: R-HSA-72163;Reactome: R-HSA-6782210	"Formation of TC-NER Pre-Incision Complex";"Dual incision in TC-NER";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"mRNA Splicing - Major Pathway";"Gap-filling DNA repair synthesis and ligation in TC-NER"
XP_046436335.1	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
XP_046424332.1	14	MetaCyc: PWY-6433;Reactome: R-HSA-75876;MetaCyc: PWY-5972;MetaCyc: PWY-7724;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7601;MetaCyc: PWY-5080;MetaCyc: PWY-7725;MetaCyc: PWY-7619;MetaCyc: PWY-7035;MetaCyc: PWY-7602;MetaCyc: PWY-6598;MetaCyc: PWY-7036;MetaCyc: PWY-8041	"Hydroxylated fatty acid biosynthesis (plants)";"Synthesis of very long-chain fatty acyl-CoAs";"Stearate biosynthesis I (animals)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Fatty acid elongation";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis I";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Juniperonate biosynthesis";"(9Z)-tricosene biosynthesis";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Sciadonate biosynthesis";"Very long chain fatty acid biosynthesis II";"Ultra-long-chain fatty acid biosynthesis"
XP_046433457.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_046420642.1	2	KEGG: 00970+6.1.1.5;Reactome: R-HSA-379726	"Aminoacyl-tRNA biosynthesis";"Mitochondrial tRNA aminoacylation"
XP_046415816.1	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
XP_046426671.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_046420722.1	14	MetaCyc: PWY-7602;MetaCyc: PWY-6598;MetaCyc: PWY-7036;MetaCyc: PWY-8041;MetaCyc: PWY-7035;MetaCyc: PWY-7725;MetaCyc: PWY-7619;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7601;MetaCyc: PWY-5080;Reactome: R-HSA-75876;MetaCyc: PWY-5972;MetaCyc: PWY-7724;MetaCyc: PWY-6433	"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Sciadonate biosynthesis";"Very long chain fatty acid biosynthesis II";"Ultra-long-chain fatty acid biosynthesis";"(9Z)-tricosene biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Juniperonate biosynthesis";"Fatty acid elongation";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis I";"Synthesis of very long-chain fatty acyl-CoAs";"Stearate biosynthesis I (animals)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Hydroxylated fatty acid biosynthesis (plants)"
XP_046434734.1	1	Reactome: R-HSA-191859	"snRNP Assembly"
XP_046435424.1	3	MetaCyc: PWY-4261;Reactome: R-HSA-75109;KEGG: 00561+2.7.1.30	"Glycerol degradation I";"Triglyceride biosynthesis";"Glycerolipid metabolism"
XP_046435709.1	2	Reactome: R-HSA-2142753;KEGG: 00970+6.3.5.7	"Arachidonic acid metabolism";"Aminoacyl-tRNA biosynthesis"
XP_046411563.1	1	Reactome: R-HSA-429947	"Deadenylation of mRNA"
XP_046420005.1	11	KEGG: 04151+2.7.11.1;Reactome: R-HSA-3270619;KEGG: 04150+2.7.11.1;KEGG: 05163+2.7.11.1;Reactome: R-HSA-8866654;KEGG: 04926+2.7.11.1;Reactome: R-HSA-1834949;Reactome: R-HSA-5693571;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1	"PI3K-Akt signaling pathway";"IRF3-mediated induction of type I IFN";"mTOR signaling pathway";"Human cytomegalovirus infection";"E3 ubiquitin ligases ubiquitinate target proteins";"Relaxin signaling pathway";"Cytosolic sensors of pathogen-associated DNA";"Nonhomologous End-Joining (NHEJ)";"Thermogenesis";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection"
XP_046409401.1	3	Reactome: R-HSA-74259;Reactome: R-HSA-196807;Reactome: R-HSA-73621	"Purine catabolism";"Nicotinate metabolism";"Pyrimidine catabolism"
XP_046419904.1	4	Reactome: R-HSA-983712;Reactome: R-HSA-1222556;Reactome: R-HSA-77387;Reactome: R-HSA-917977	"Ion channel transport";"ROS and RNS production in phagocytes";"Insulin receptor recycling";"Transferrin endocytosis and recycling"
XP_046427243.1	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
XP_046410164.1	1	Reactome: R-HSA-77289	"Mitochondrial Fatty Acid Beta-Oxidation"
XP_046429688.1	1	Reactome: R-HSA-388844	"Receptor-type tyrosine-protein phosphatases"
XP_046419073.1	1	Reactome: R-HSA-5658442	"Regulation of RAS by GAPs"
XP_046410598.1	1	Reactome: R-HSA-6799198	"Complex I biogenesis"
XP_046422660.1	4	Reactome: R-HSA-73856;Reactome: R-HSA-72163;Reactome: R-HSA-72187;Reactome: R-HSA-159236	"RNA Polymerase II Transcription Termination";"mRNA Splicing - Major Pathway";"mRNA 3'-end processing";"Transport of Mature mRNA derived from an Intron-Containing Transcript"
XP_046425179.1	1	Reactome: R-HSA-4615885	"SUMOylation of DNA replication proteins"
XP_046434976.1	1	Reactome: R-HSA-390651	"Dopamine receptors"
XP_046424959.1	4	Reactome: R-HSA-6781823;Reactome: R-HSA-8951664;Reactome: R-HSA-5696394;Reactome: R-HSA-8856825	"Formation of TC-NER Pre-Incision Complex";"Neddylation";"DNA Damage Recognition in GG-NER";"Cargo recognition for clathrin-mediated endocytosis"
XP_046420816.1	5	Reactome: R-HSA-9648895;Reactome: R-HSA-380994;Reactome: R-HSA-9633012;KEGG: 00250+6.3.5.4;Reactome: R-HSA-8963693	"Response of EIF2AK1 (HRI) to heme deficiency";"ATF4 activates genes in response to endoplasmic reticulum stress";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Alanine, aspartate and glutamate metabolism";"Aspartate and asparagine metabolism"
XP_046424393.1	1	Reactome: R-HSA-2393930	"Phosphate bond hydrolysis by NUDT proteins"
XP_046426543.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_046420074.1	7	KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1	"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Relaxin signaling pathway";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Human cytomegalovirus infection";"Thermogenesis"
XP_046429300.1	1	Reactome: R-HSA-400253	"Circadian Clock"
XP_046418323.1	7	Reactome: R-HSA-1362300;Reactome: R-HSA-156711;Reactome: R-HSA-69205;Reactome: R-HSA-1362277;Reactome: R-HSA-69656;Reactome: R-HSA-69202;Reactome: R-HSA-1538133	"Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1";"Polo-like kinase mediated events";"G1/S-Specific Transcription";"Transcription of E2F targets under negative control by DREAM complex";"Cyclin A:Cdk2-associated events at S phase entry";"Cyclin E associated events during G1/S transition";"G0 and Early G1"
XP_046428323.1	2	Reactome: R-HSA-4641265;Reactome: R-HSA-5339700	"Repression of WNT target genes";"TCF7L2 mutants don't bind CTBP"
XP_046431205.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_046417637.1	4	KEGG: 00592+3.1.1.32;MetaCyc: PWY-8051;MetaCyc: PWY-6803;KEGG: 00564+3.1.1.32	"alpha-Linolenic acid metabolism";"Anandamide biosynthesis I";"Phosphatidylcholine acyl editing";"Glycerophospholipid metabolism"
XP_046436193.1	1	Reactome: R-HSA-418594	"G alpha (i) signalling events"
XP_046418624.1	6	Reactome: R-HSA-72689;Reactome: R-HSA-156827;Reactome: R-HSA-72706;Reactome: R-HSA-72695;Reactome: R-HSA-72702;Reactome: R-HSA-72649	"Formation of a pool of free 40S subunits";"L13a-mediated translational silencing of Ceruloplasmin expression";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Formation of the ternary complex, and subsequently, the 43S complex";"Ribosomal scanning and start codon recognition";"Translation initiation complex formation"
XP_046421634.1	3	MetaCyc: PWY-6369;Reactome: R-HSA-1855167;KEGG: 04070+2.7.4.24+2.7.4.21	"Inositol diphosphates biosynthesis";"Synthesis of pyrophosphates in the cytosol";"Phosphatidylinositol signaling system"
XP_046421615.1	3	KEGG: 04070+2.7.4.24+2.7.4.21;MetaCyc: PWY-6369;Reactome: R-HSA-1855167	"Phosphatidylinositol signaling system";"Inositol diphosphates biosynthesis";"Synthesis of pyrophosphates in the cytosol"
XP_046420150.1	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
XP_046420273.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046426968.1	10	KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;Reactome: R-HSA-5357905;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;Reactome: R-HSA-5357956;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04660+2.7.10.2	"Human cytomegalovirus infection";"Relaxin signaling pathway";"Regulation of TNFR1 signaling";"mTOR signaling pathway";"PI3K-Akt signaling pathway";"TNFR1-induced NFkappaB signaling pathway";"Thermogenesis";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"T cell receptor signaling pathway"
XP_046435343.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_046436680.1	12	Reactome: R-HSA-2500257;Reactome: R-HSA-5663220;Reactome: R-HSA-3371497;Reactome: R-HSA-6807878;Reactome: R-HSA-2132295;Reactome: R-HSA-141444;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813;Reactome: R-HSA-9646399;Reactome: R-HSA-6811436;Reactome: R-HSA-68877;Reactome: R-HSA-9609690	"Resolution of Sister Chromatid Cohesion";"RHO GTPases Activate Formins";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-mediated anterograde transport";"MHC class II antigen presentation";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids";"Aggrephagy";"COPI-independent Golgi-to-ER retrograde traffic";"Mitotic Prometaphase";"HCMV Early Events"
XP_046430198.1	2	Reactome: R-HSA-3928665;Reactome: R-HSA-2682334	"EPH-ephrin mediated repulsion of cells";"EPH-Ephrin signaling"
XP_046434314.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_046427727.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_046425447.1	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286	"Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation"
XP_046415587.1	1	Reactome: R-HSA-433137	"Sodium-coupled sulphate, di- and tri-carboxylate transporters"
XP_046413877.1	3	Reactome: R-HSA-6784531;MetaCyc: PWY-7803;MetaCyc: PWY-6689	"tRNA processing in the nucleus";"Trna splicing II";"Trna splicing I"
XP_046420117.1	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
XP_046433943.1	5	Reactome: R-HSA-6782135;Reactome: R-HSA-6781823;Reactome: R-HSA-6781827;Reactome: R-HSA-72163;Reactome: R-HSA-6782210	"Dual incision in TC-NER";"Formation of TC-NER Pre-Incision Complex";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"mRNA Splicing - Major Pathway";"Gap-filling DNA repair synthesis and ligation in TC-NER"
XP_046415756.1	7	KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1	"Human cytomegalovirus infection";"Thermogenesis";"Relaxin signaling pathway";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"mTOR signaling pathway"
XP_046435293.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_046420944.1	3	Reactome: R-HSA-5423646;MetaCyc: PWY-7533;Reactome: R-HSA-2142691	"Aflatoxin activation and detoxification";"Gliotoxin biosynthesis";"Synthesis of Leukotrienes (LT) and Eoxins (EX)"
XP_046431336.1	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
XP_046415303.1	2	Reactome: R-HSA-6811438;Reactome: R-HSA-6807878	"Intra-Golgi traffic";"COPI-mediated anterograde transport"
XP_046434914.1	5	Reactome: R-HSA-2029482;Reactome: R-HSA-6798695;Reactome: R-HSA-5663213;Reactome: R-HSA-8856828;Reactome: R-HSA-3928662	"Regulation of actin dynamics for phagocytic cup formation";"Neutrophil degranulation";"RHO GTPases Activate WASPs and WAVEs";"Clathrin-mediated endocytosis";"EPHB-mediated forward signaling"
XP_046435694.1	1	MetaCyc: PWY-6308	"L-cysteine biosynthesis II (tRNA-dependent)"
XP_046433158.1	13	Reactome: R-HSA-72689;Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-192823;Reactome: R-HSA-72706;Reactome: R-HSA-2408557;Reactome: R-HSA-1799339;Reactome: R-HSA-975957;Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-975956;Reactome: R-HSA-72764	"Formation of a pool of free 40S subunits";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Viral mRNA Translation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Selenocysteine synthesis";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination"
XP_046415569.1	4	Reactome: R-HSA-196108;Reactome: R-HSA-5579026;Reactome: R-HSA-2395516;Reactome: R-HSA-211976	"Pregnenolone biosynthesis";"Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)";"Electron transport from NADPH to Ferredoxin";"Endogenous sterols"
XP_046411763.1	4	Reactome: R-HSA-983712;Reactome: R-HSA-917977;Reactome: R-HSA-77387;Reactome: R-HSA-1222556	"Ion channel transport";"Transferrin endocytosis and recycling";"Insulin receptor recycling";"ROS and RNS production in phagocytes"
XP_046427498.1	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
XP_046421543.1	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046419979.1	19	Reactome: R-HSA-936837;Reactome: R-HSA-5578775;Reactome: R-HSA-399719;Reactome: R-HSA-9609736;Reactome: R-HSA-9022692;Reactome: R-HSA-111932;Reactome: R-HSA-438066;Reactome: R-HSA-9617324;Reactome: R-HSA-5576892;Reactome: R-HSA-877300;Reactome: R-HSA-6802955;Reactome: R-HSA-442982;Reactome: R-HSA-9649948;Reactome: R-HSA-6802952;Reactome: R-HSA-3371571;Reactome: R-HSA-5673001;Reactome: R-HSA-9620244;Reactome: R-HSA-5673000;Reactome: R-HSA-6802946	"Ion transport by P-type ATPases";"Ion homeostasis";"Trafficking of AMPA receptors";"Assembly and cell surface presentation of NMDA receptors";"Regulation of MECP2 expression and activity";"CaMK IV-mediated phosphorylation of CREB";"Unblocking of NMDA receptors, glutamate binding and activation";"Negative regulation of NMDA receptor-mediated neuronal transmission";"Phase 0 - rapid depolarisation";"Interferon gamma signaling";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"Ras activation upon Ca2+ influx through NMDA receptor";"Signaling downstream of RAS mutants";"Signaling by BRAF and RAF fusions";"HSF1-dependent transactivation";"RAF/MAP kinase cascade";"Long-term potentiation";"RAF activation";"Signaling by moderate kinase activity BRAF mutants"
XP_046421889.1	2	Reactome: R-HSA-1660661;KEGG: 04070+2.7.11.13	"Sphingolipid de novo biosynthesis";"Phosphatidylinositol signaling system"
XP_046420982.1	13	Reactome: R-HSA-9633012;Reactome: R-HSA-72689;Reactome: R-HSA-192823;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-2408557;Reactome: R-HSA-72706;Reactome: R-HSA-1799339;Reactome: R-HSA-975957;Reactome: R-HSA-6791226;Reactome: R-HSA-975956;Reactome: R-HSA-156902;Reactome: R-HSA-72764	"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Formation of a pool of free 40S subunits";"Viral mRNA Translation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Selenocysteine synthesis";"GTP hydrolysis and joining of the 60S ribosomal subunit";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Peptide chain elongation";"Eukaryotic Translation Termination"
XP_046419766.1	1	Reactome: R-HSA-420499	"Class C/3 (Metabotropic glutamate/pheromone receptors)"
XP_046415752.1	7	KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1	"Thermogenesis";"Human cytomegalovirus infection";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Relaxin signaling pathway";"mTOR signaling pathway";"PI3K-Akt signaling pathway"
XP_046426632.1	4	Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-1268020;Reactome: R-HSA-5419276	"Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial protein import";"Mitochondrial translation termination"
XP_046436676.1	12	Reactome: R-HSA-2132295;Reactome: R-HSA-9648025;Reactome: R-HSA-141444;Reactome: R-HSA-68877;Reactome: R-HSA-9609690;Reactome: R-HSA-9646399;Reactome: R-HSA-2467813;Reactome: R-HSA-6811436;Reactome: R-HSA-5663220;Reactome: R-HSA-2500257;Reactome: R-HSA-3371497;Reactome: R-HSA-6807878	"MHC class II antigen presentation";"EML4 and NUDC in mitotic spindle formation";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Mitotic Prometaphase";"HCMV Early Events";"Aggrephagy";"Separation of Sister Chromatids";"COPI-independent Golgi-to-ER retrograde traffic";"RHO GTPases Activate Formins";"Resolution of Sister Chromatid Cohesion";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-mediated anterograde transport"
XP_046421574.1	3	Reactome: R-HSA-5632968;Reactome: R-HSA-5632928;Reactome: R-HSA-5358565	"Defective Mismatch Repair Associated With MSH6";"Defective Mismatch Repair Associated With MSH2";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)"
XP_046433407.1	2	Reactome: R-HSA-163210;Reactome: R-HSA-8949613	"Formation of ATP by chemiosmotic coupling";"Cristae formation"
XP_046418778.1	7	Reactome: R-HSA-5358346;Reactome: R-HSA-5632681;Reactome: R-HSA-5632684;Reactome: R-HSA-5658034;Reactome: R-HSA-373080;Reactome: R-HSA-5635838;Reactome: R-HSA-5362798	"Hedgehog ligand biogenesis";"Ligand-receptor interactions";"Hedgehog 'on' state";"HHAT G278V abrogates palmitoylation of Hh-Np";"Class B/2 (Secretin family receptors)";"Activation of SMO";"Release of Hh-Np from the secreting cell"
XP_046433789.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046423921.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_046419364.1	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
XP_046421984.1	2	Reactome: R-HSA-418457;Reactome: R-HSA-1296052	"cGMP effects";"Ca2+ activated K+ channels"
XP_046419329.1	4	Reactome: R-HSA-8856828;Reactome: R-HSA-6794361;Reactome: R-HSA-8856825;Reactome: R-HSA-5250958	"Clathrin-mediated endocytosis";"Neurexins and neuroligins";"Cargo recognition for clathrin-mediated endocytosis";"Toxicity of botulinum toxin type B (BoNT/B)"
XP_046429942.1	3	Reactome: R-HSA-5083627;Reactome: R-HSA-5173105;Reactome: R-HSA-2022854	"Defective LARGE causes MDDGA6 and MDDGB6";"O-linked glycosylation";"Keratan sulfate biosynthesis"
XP_046422483.1	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
XP_046434516.1	1	Reactome: R-HSA-176974	"Unwinding of DNA"
XP_046423993.1	1	Reactome: R-HSA-901032	"ER Quality Control Compartment (ERQC)"
XP_046410514.1	6	Reactome: R-HSA-114508;KEGG: 00564+2.7.1.107;KEGG: 04070+2.7.1.107;KEGG: 00561+2.7.1.107;MetaCyc: PWY-7039;MetaCyc: PWY-7817	"Effects of PIP2 hydrolysis";"Glycerophospholipid metabolism";"Phosphatidylinositol signaling system";"Glycerolipid metabolism";"Phosphatidate metabolism, as a signaling molecule";"Type I lipoteichoic acid biosynthesis (S. aureus)"
XP_046426481.1	2	Reactome: R-HSA-426117;Reactome: R-HSA-5619039	"Cation-coupled Chloride cotransporters";"Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)"
XP_046420271.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046409412.1	2	Reactome: R-HSA-416476;Reactome: R-HSA-375276	"G alpha (q) signalling events";"Peptide ligand-binding receptors"
XP_046419495.1	3	Reactome: R-HSA-8874081;Reactome: R-HSA-3000171;Reactome: R-HSA-3000157	"MET activates PTK2 signaling";"Non-integrin membrane-ECM interactions";"Laminin interactions"
XP_046432421.1	15	MetaCyc: PWY-6901;MetaCyc: PWY-6886;MetaCyc: PWY-7218;MetaCyc: PWY-6142;MetaCyc: PWY-5723;KEGG: 00010+2.7.1.40;MetaCyc: PWY-2221;MetaCyc: PWY-8004;MetaCyc: PWY-1042;MetaCyc: PWY-7383;Reactome: R-HSA-70171;MetaCyc: PWY-7003;KEGG: 00620+2.7.1.40;MetaCyc: PWY-5484;KEGG: 00230+2.7.1.40	"Superpathway of glucose and xylose degradation";"1-butanol autotrophic biosynthesis (engineered)";"Photosynthetic 3-hydroxybutanoate biosynthesis (engineered)";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Rubisco shunt";"Glycolysis / Gluconeogenesis";"Entner-Doudoroff pathway III (semi-phosphorylative)";"Entner-Doudoroff pathway I";"Glycolysis IV (plant cytosol)";"Anaerobic energy metabolism (invertebrates, cytosol)";"Glycolysis";"Glycerol degradation to butanol";"Pyruvate metabolism";"Glycolysis II (from fructose 6-phosphate)";"Purine metabolism"
XP_046410594.1	1	Reactome: R-HSA-6799198	"Complex I biogenesis"
XP_046432317.1	3	Reactome: R-HSA-6811440;Reactome: R-HSA-6807878;Reactome: R-HSA-6811438	"Retrograde transport at the Trans-Golgi-Network";"COPI-mediated anterograde transport";"Intra-Golgi traffic"
XP_046413788.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046427728.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_046421027.1	6	Reactome: R-HSA-9640463;MetaCyc: PWY-6733;KEGG: 00073+1.2.1.84;MetaCyc: PWY-7656;MetaCyc: PWY-7782;MetaCyc: PWY-5884	"Wax biosynthesis";"Sporopollenin precursors biosynthesis";"Cutin, suberine and wax biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Plasmalogen biosynthesis";"Wax esters biosynthesis I"
XP_046427789.1	10	MetaCyc: PWY-5826;MetaCyc: PWY-6842;MetaCyc: PWY-7559;KEGG: 00480+2.3.2.2+3.4.19.13;KEGG: 00430+2.3.2.2;MetaCyc: PWY-4061;MetaCyc: PWY-7112;KEGG: 00460+2.3.2.2;MetaCyc: PWY-8001;MetaCyc: PWY-4041	"Hypoglycin biosynthesis";"Glutathione-mediated detoxification II";"Glutathione degradation (DUG pathway";"Glutathione metabolism";"Taurine and hypotaurine metabolism";"Glutathione-mediated detoxification I";"4-hydroxy-2-nonenal detoxification";"Cyanoamino acid metabolism";"Felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis";"Gamma-glutamyl cycle"
XP_046436012.1	1	Reactome: R-HSA-216083	"Integrin cell surface interactions"
XP_046421036.1	2	Reactome: R-HSA-3295583;Reactome: R-HSA-418890	"TRP channels";"Role of second messengers in netrin-1 signaling"
XP_046431322.1	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
XP_046417582.1	1	Reactome: R-HSA-162791	"Attachment of GPI anchor to uPAR"
XP_046425003.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_046427809.1	4	Reactome: R-HSA-5693579;Reactome: R-HSA-5685942;Reactome: R-HSA-5693554;Reactome: R-HSA-5693568	"Homologous DNA Pairing and Strand Exchange";"HDR through Homologous Recombination (HRR)";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Resolution of D-loop Structures through Holliday Junction Intermediates"
XP_046421050.1	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
XP_046419161.1	9	Reactome: R-HSA-6802952;Reactome: R-HSA-6802948;Reactome: R-HSA-9649948;Reactome: R-HSA-5674135;Reactome: R-HSA-6802955;Reactome: R-HSA-114608;Reactome: R-HSA-445355;Reactome: R-HSA-6798695;Reactome: R-HSA-6802946	"Signaling by BRAF and RAF fusions";"Signaling by high-kinase activity BRAF mutants";"Signaling downstream of RAS mutants";"MAP2K and MAPK activation";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"Platelet degranulation";"Smooth Muscle Contraction";"Neutrophil degranulation";"Signaling by moderate kinase activity BRAF mutants"
XP_046422128.1	1	Reactome: R-HSA-2564830	"Cytosolic iron-sulfur cluster assembly"
XP_046429539.1	1	Reactome: R-HSA-5620922	"BBSome-mediated cargo-targeting to cilium"
XP_046410158.1	13	Reactome: R-HSA-72764;Reactome: R-HSA-975956;Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-975957;Reactome: R-HSA-1799339;Reactome: R-HSA-2408557;Reactome: R-HSA-72706;Reactome: R-HSA-192823;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-72689	"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"Selenocysteine synthesis";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Formation of a pool of free 40S subunits"
XP_046433884.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_046429188.1	6	KEGG: 00512+2.4.1.122;Reactome: R-HSA-5083632;Reactome: R-HSA-913709;KEGG: 00514+2.4.1.122;MetaCyc: PWY-7433;MetaCyc: PWY-7290	"Mucin type O-glycan biosynthesis";"Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)";"O-linked glycosylation of mucins";"Other types of O-glycan biosynthesis";"Mucin core 1 and core 2 O-glycosylation";"Escherichia coli serotype O86 O-antigen biosynthesis"
XP_046409665.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_046431788.1	10	Reactome: R-HSA-8951664;Reactome: R-HSA-5607761;Reactome: R-HSA-983168;Reactome: R-HSA-202424;Reactome: R-HSA-5676590;Reactome: R-HSA-5607764;Reactome: R-HSA-5684264;Reactome: R-HSA-1169091;Reactome: R-HSA-2565942;Reactome: R-HSA-2871837	"Neddylation";"Dectin-1 mediated noncanonical NF-kB signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Downstream TCR signaling";"NIK-->noncanonical NF-kB signaling";"CLEC7A (Dectin-1) signaling";"MAP3K8 (TPL2)-dependent MAPK1/3 activation";"Activation of NF-kappaB in B cells";"Regulation of PLK1 Activity at G2/M Transition";"FCERI mediated NF-kB activation"
XP_046412231.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046420451.1	2	Reactome: R-HSA-6798695;Reactome: R-HSA-2022377	"Neutrophil degranulation";"Metabolism of Angiotensinogen to Angiotensins"
XP_046421817.1	5	Reactome: R-HSA-6814122;Reactome: R-HSA-389960;Reactome: R-HSA-389957;Reactome: R-HSA-390450;Reactome: R-HSA-390471	"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"Formation of tubulin folding intermediates by CCT/TriC";"Prefoldin mediated transfer of substrate to CCT/TriC";"Folding of actin by CCT/TriC";"Association of TriC/CCT with target proteins during biosynthesis"
XP_046427622.1	1	Reactome: R-HSA-3214842	"HDMs demethylate histones"
XP_046418511.1	4	Reactome: R-HSA-76066;Reactome: R-HSA-76061;Reactome: R-HSA-76071;Reactome: R-HSA-749476	"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Abortive And Retractive Initiation"
XP_046410923.1	14	MetaCyc: PWY-7035;MetaCyc: PWY-8041;MetaCyc: PWY-7602;MetaCyc: PWY-6598;MetaCyc: PWY-7036;MetaCyc: PWY-5080;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7601;MetaCyc: PWY-7619;MetaCyc: PWY-7725;MetaCyc: PWY-7724;MetaCyc: PWY-5972;Reactome: R-HSA-75876;MetaCyc: PWY-6433	"(9Z)-tricosene biosynthesis";"Ultra-long-chain fatty acid biosynthesis";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Sciadonate biosynthesis";"Very long chain fatty acid biosynthesis II";"Very long chain fatty acid biosynthesis I";"Fatty acid elongation";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Juniperonate biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Stearate biosynthesis I (animals)";"Synthesis of very long-chain fatty acyl-CoAs";"Hydroxylated fatty acid biosynthesis (plants)"
XP_046435692.1	1	MetaCyc: PWY-6308	"L-cysteine biosynthesis II (tRNA-dependent)"
XP_046432995.1	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840	"Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation"
XP_046412112.1	17	Reactome: R-HSA-8953750;Reactome: R-HSA-9616222;Reactome: R-HSA-1362300;Reactome: R-HSA-113501;Reactome: R-HSA-1362277;Reactome: R-HSA-69205;Reactome: R-HSA-2559580;Reactome: R-HSA-69656;Reactome: R-HSA-69202;Reactome: R-HSA-111448;Reactome: R-HSA-1912408;Reactome: R-HSA-6804114;Reactome: R-HSA-2559585;Reactome: R-HSA-139915;Reactome: R-HSA-2173796;Reactome: R-HSA-1538133;Reactome: R-HSA-69231	"Transcriptional Regulation by E2F6";"Transcriptional regulation of granulopoiesis";"Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1";"Inhibition of replication initiation of damaged DNA by RB1/E2F1";"Transcription of E2F targets under negative control by DREAM complex";"G1/S-Specific Transcription";"Oxidative Stress Induced Senescence";"Cyclin A:Cdk2-associated events at S phase entry";"Cyclin E associated events during G1/S transition";"Activation of NOXA and translocation to mitochondria";"Pre-NOTCH Transcription and Translation";"TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest";"Oncogene Induced Senescence";"Activation of PUMA and translocation to mitochondria";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"G0 and Early G1";"Cyclin D associated events in G1"
XP_046418936.1	1	Reactome: R-HSA-5693571	"Nonhomologous End-Joining (NHEJ)"
XP_046433810.1	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
XP_046424629.1	4	Reactome: R-HSA-4655427;KEGG: 00270+2.1.1.37;Reactome: R-HSA-5334118;Reactome: R-HSA-212300	"SUMOylation of DNA methylation proteins";"Cysteine and methionine metabolism";"DNA methylation";"PRC2 methylates histones and DNA"
XP_046432830.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_046434136.1	13	MetaCyc: PWY-6902;MetaCyc: PWY-7822;KEGG: 00513+3.2.1.52;Reactome: R-HSA-2160916;KEGG: 00531+3.2.1.52;KEGG: 00520+3.2.1.52;Reactome: R-HSA-2024101;Reactome: R-HSA-1660662;MetaCyc: PWY-7883;Reactome: R-HSA-2022857;KEGG: 00604+3.2.1.52;KEGG: 00511+3.2.1.52;KEGG: 00603+3.2.1.52	"Chitin degradation II (Vibrio)";"Chitin degradation III (Serratia)";"Various types of N-glycan biosynthesis";"Hyaluronan uptake and degradation";"Glycosaminoglycan degradation";"Amino sugar and nucleotide sugar metabolism";"CS/DS degradation";"Glycosphingolipid metabolism";"Anhydromuropeptides recycling II";"Keratan sulfate degradation";"Glycosphingolipid biosynthesis - ganglio series";"Other glycan degradation";"Glycosphingolipid biosynthesis - globo and isoglobo series"
XP_046431847.1	2	Reactome: R-HSA-8939243;Reactome: R-HSA-3214858	"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RMTs methylate histone arginines"
XP_046424137.1	6	Reactome: R-HSA-399997;Reactome: R-HSA-418592;Reactome: R-HSA-434316;Reactome: R-HSA-416476;Reactome: R-HSA-456926;Reactome: R-HSA-428930	"Acetylcholine regulates insulin secretion";"ADP signalling through P2Y purinoceptor 1";"Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion";"G alpha (q) signalling events";"Thrombin signalling through proteinase activated receptors (PARs)";"Thromboxane signalling through TP receptor"
XP_046429938.1	3	Reactome: R-HSA-5173105;Reactome: R-HSA-5083627;Reactome: R-HSA-2022854	"O-linked glycosylation";"Defective LARGE causes MDDGA6 and MDDGB6";"Keratan sulfate biosynthesis"
XP_046435039.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_046436677.1	12	Reactome: R-HSA-2132295;Reactome: R-HSA-141444;Reactome: R-HSA-9648025;Reactome: R-HSA-6811436;Reactome: R-HSA-2467813;Reactome: R-HSA-9646399;Reactome: R-HSA-9609690;Reactome: R-HSA-68877;Reactome: R-HSA-2500257;Reactome: R-HSA-5663220;Reactome: R-HSA-3371497;Reactome: R-HSA-6807878	"MHC class II antigen presentation";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"EML4 and NUDC in mitotic spindle formation";"COPI-independent Golgi-to-ER retrograde traffic";"Separation of Sister Chromatids";"Aggrephagy";"HCMV Early Events";"Mitotic Prometaphase";"Resolution of Sister Chromatid Cohesion";"RHO GTPases Activate Formins";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-mediated anterograde transport"
XP_046425874.1	3	Reactome: R-HSA-418359;Reactome: R-HSA-5578775;Reactome: R-HSA-936837	"Reduction of cytosolic Ca++ levels";"Ion homeostasis";"Ion transport by P-type ATPases"
XP_046434586.1	22	Reactome: R-HSA-432142;Reactome: R-HSA-5675221;Reactome: R-HSA-5339716;Reactome: R-HSA-4641262;Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-5467348;Reactome: R-HSA-5467337;Reactome: R-HSA-196299;Reactome: R-HSA-5358749;Reactome: R-HSA-6811558;Reactome: R-HSA-5358747;Reactome: R-HSA-5467340;Reactome: R-HSA-9648025;Reactome: R-HSA-5358751;Reactome: R-HSA-141444;Reactome: R-HSA-195253;Reactome: R-HSA-5358752;Reactome: R-HSA-2467813;Reactome: R-HSA-2500257;Reactome: R-HSA-5673000;Reactome: R-HSA-389513	"Platelet sensitization by LDL";"Negative regulation of MAPK pathway";"Misspliced GSK3beta mutants stabilize beta-catenin";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"Mitotic Prometaphase";"RHO GTPases Activate Formins";"Truncations of AMER1 destabilize the destruction complex";"APC truncation mutants have impaired AXIN binding";"Beta-catenin phosphorylation cascade";"S37 mutants of beta-catenin aren't phosphorylated";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"S33 mutants of beta-catenin aren't phosphorylated";"AXIN missense mutants destabilize the destruction complex";"EML4 and NUDC in mitotic spindle formation";"S45 mutants of beta-catenin aren't phosphorylated";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Degradation of beta-catenin by the destruction complex";"T41 mutants of beta-catenin aren't phosphorylated";"Separation of Sister Chromatids";"Resolution of Sister Chromatid Cohesion";"RAF activation";"CTLA4 inhibitory signaling"
XP_046423230.1	20	KEGG: 00592+1.3.3.6;KEGG: 00640+1.3.3.6;MetaCyc: PWY-735;MetaCyc: PWY-6837;Reactome: R-HSA-9033241;KEGG: 00410+1.3.3.6;MetaCyc: PWY-5136;MetaCyc: PWY-7291;MetaCyc: PWY-7858;MetaCyc: PWY-6920;MetaCyc: PWY-7338;KEGG: 00071+1.3.3.6;MetaCyc: PWY-7288;MetaCyc: PWY-7340;MetaCyc: PWY-7574;MetaCyc: PWY-7337;MetaCyc: PWY-7007;MetaCyc: PWY-7854;MetaCyc: PWY-7606;MetaCyc: PWY-7726	"alpha-Linolenic acid metabolism";"Propanoate metabolism";"Jasmonic acid biosynthesis";"Fatty acid beta-oxidation V (unsaturated, odd number, di-isomerase-dependent)";"Peroxisomal protein import";"beta-Alanine metabolism";"Fatty acid beta-oxidation II (plant peroxisome)";"Oleate beta-oxidation (isomerase-dependent, yeast)";"(5Z)-dodecenoate biosynthesis II";"6-gingerol analog biosynthesis (engineered)";"10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast)";"Fatty acid degradation";"Fatty acid beta-oxidation VII (yeast peroxisome)";"9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast)";"Propanoyl-coa degradation II";"10-cis-heptadecenoyl-CoA degradation (yeast)";"Methyl ketone biosynthesis (engineered)";"Crotonyl-coa/ethylmalonyl-coa/hydroxybutyryl-coa cycle (engineered)";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)"
XP_046421524.1	3	Reactome: R-HSA-192456;MetaCyc: PWY-6857;KEGG: 00561+3.1.1.3	"Digestion of dietary lipid";"Retinol biosynthesis";"Glycerolipid metabolism"
XP_046428582.1	3	Reactome: R-HSA-193648;Reactome: R-HSA-194840;Reactome: R-HSA-416482	"NRAGE signals death through JNK";"Rho GTPase cycle";"G alpha (12/13) signalling events"
XP_046416923.1	14	MetaCyc: PWY-7417;KEGG: 00591+3.1.1.4;MetaCyc: PWY-8053;MetaCyc: PWY-7416;MetaCyc: PWY-7409;KEGG: 00592+3.1.1.4;MetaCyc: PWY-7783;KEGG: 00590+3.1.1.4;Reactome: R-HSA-975634;KEGG: 00565+3.1.1.4;Reactome: R-HSA-1482788;MetaCyc: PWY-6803;MetaCyc: PWY-8051;KEGG: 00564+3.1.1.4+3.1.1.5	"Phospholipid remodeling (phosphatidate, yeast)";"Linoleic acid metabolism";"Anandamide biosynthesis II";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"alpha-Linolenic acid metabolism";"Plasmalogen degradation";"Arachidonic acid metabolism";"Retinoid metabolism and transport";"Ether lipid metabolism";"Acyl chain remodelling of PC";"Phosphatidylcholine acyl editing";"Anandamide biosynthesis I";"Glycerophospholipid metabolism"
XP_046430147.1	13	Reactome: R-HSA-2408557;Reactome: R-HSA-72706;Reactome: R-HSA-1799339;Reactome: R-HSA-72689;Reactome: R-HSA-9633012;Reactome: R-HSA-192823;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-975956;Reactome: R-HSA-156902;Reactome: R-HSA-72764;Reactome: R-HSA-975957;Reactome: R-HSA-6791226	"Selenocysteine synthesis";"GTP hydrolysis and joining of the 60S ribosomal subunit";"SRP-dependent cotranslational protein targeting to membrane";"Formation of a pool of free 40S subunits";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Peptide chain elongation";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046418295.1	1	Reactome: R-HSA-418886	"Netrin mediated repulsion signals"
XP_046424985.1	11	Reactome: R-HSA-418594;Reactome: R-HSA-432040;Reactome: R-HSA-163615;Reactome: R-HSA-5610787;KEGG: 00230+4.6.1.1;Reactome: R-HSA-170670;Reactome: R-HSA-163359;Reactome: R-HSA-164378;Reactome: R-HSA-418555;Reactome: R-HSA-418597;Reactome: R-HSA-170660	"G alpha (i) signalling events";"Vasopressin regulates renal water homeostasis via Aquaporins";"PKA activation";"Hedgehog 'off' state";"Purine metabolism";"Adenylate cyclase inhibitory pathway";"Glucagon signaling in metabolic regulation";"PKA activation in glucagon signalling";"G alpha (s) signalling events";"G alpha (z) signalling events";"Adenylate cyclase activating pathway"
XP_046423924.1	6	Reactome: R-HSA-9640463;MetaCyc: PWY-6733;MetaCyc: PWY-7656;KEGG: 00073+1.2.1.84;MetaCyc: PWY-7782;MetaCyc: PWY-5884	"Wax biosynthesis";"Sporopollenin precursors biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Cutin, suberine and wax biosynthesis";"Plasmalogen biosynthesis";"Wax esters biosynthesis I"
XP_046422329.1	1	Reactome: R-HSA-5663220	"RHO GTPases Activate Formins"
XP_046433895.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046424292.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-5628897	"Respiratory electron transport";"TP53 Regulates Metabolic Genes"
XP_046409868.1	1	Reactome: R-HSA-6783984	"Glycine degradation"
XP_046412692.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046418014.1	4	Reactome: R-HSA-382556;Reactome: R-HSA-5678895;Reactome: R-HSA-5362768;Reactome: R-HSA-5358346	"ABC-family proteins mediated transport";"Defective CFTR causes cystic fibrosis";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Hedgehog ligand biogenesis"
XP_046417230.1	2	Reactome: R-HSA-5689880;Reactome: R-HSA-110320	"Ub-specific processing proteases";"Translesion Synthesis by POLH"
XP_046424505.1	9	Reactome: R-HSA-1475029;KEGG: 00910+4.2.1.1;MetaCyc: PWY-241;MetaCyc: PWY-5789;MetaCyc: PWY-6142;MetaCyc: PWY-5743;MetaCyc: PWY-7117;MetaCyc: PWY-5744;MetaCyc: PWY-7115	"Reversible hydration of carbon dioxide";"Nitrogen metabolism";"C4 photosynthetic carbon assimilation cycle, NADP-ME type";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"3-hydroxypropanoate cycle";"C4 photosynthetic carbon assimilation cycle, PEPCK type";"Glyoxylate assimilation";"C4 photosynthetic carbon assimilation cycle, NAD-ME type"
XP_046422280.1	1	KEGG: 00970+6.1.1.3	"Aminoacyl-tRNA biosynthesis"
XP_046417112.1	4	MetaCyc: PWY-5912;MetaCyc: PWY-5041;Reactome: R-HSA-156581;KEGG: 00270+2.5.1.6	"2'-deoxymugineic acid phytosiderophore biosynthesis";"S-adenosyl-L-methionine cycle II";"Methylation";"Cysteine and methionine metabolism"
XP_046436415.1	5	KEGG: 00983+2.4.2.3;Reactome: R-HSA-73614;KEGG: 00240+2.4.2.3;MetaCyc: PWY-5532;Reactome: R-HSA-73621	"Drug metabolism - other enzymes";"Pyrimidine salvage";"Pyrimidine metabolism";"Nucleoside and nucleotide degradation (archaea)";"Pyrimidine catabolism"
XP_046414118.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_046418409.1	1	Reactome: R-HSA-381038	"XBP1(S) activates chaperone genes"
XP_046436195.1	1	Reactome: R-HSA-418594	"G alpha (i) signalling events"
XP_046428983.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_046415484.1	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
XP_046428713.1	6	KEGG: 04070+2.7.1.107;Reactome: R-HSA-114508;KEGG: 00564+2.7.1.107;MetaCyc: PWY-7817;MetaCyc: PWY-7039;KEGG: 00561+2.7.1.107	"Phosphatidylinositol signaling system";"Effects of PIP2 hydrolysis";"Glycerophospholipid metabolism";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Phosphatidate metabolism, as a signaling molecule";"Glycerolipid metabolism"
XP_046416650.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046414361.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046433281.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-8876725	"Respiratory electron transport";"Protein methylation"
XP_046416919.1	14	MetaCyc: PWY-7416;MetaCyc: PWY-8053;MetaCyc: PWY-7409;MetaCyc: PWY-7417;KEGG: 00591+3.1.1.4;KEGG: 00565+3.1.1.4;MetaCyc: PWY-6803;Reactome: R-HSA-1482788;MetaCyc: PWY-8051;KEGG: 00564+3.1.1.4+3.1.1.5;KEGG: 00592+3.1.1.4;MetaCyc: PWY-7783;KEGG: 00590+3.1.1.4;Reactome: R-HSA-975634	"Phospholipid remodeling (phosphatidylcholine, yeast)";"Anandamide biosynthesis II";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Phospholipid remodeling (phosphatidate, yeast)";"Linoleic acid metabolism";"Ether lipid metabolism";"Phosphatidylcholine acyl editing";"Acyl chain remodelling of PC";"Anandamide biosynthesis I";"Glycerophospholipid metabolism";"alpha-Linolenic acid metabolism";"Plasmalogen degradation";"Arachidonic acid metabolism";"Retinoid metabolism and transport"
XP_046427007.1	3	KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16	"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
XP_046414168.1	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
XP_046425270.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046429008.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_046423333.1	2	KEGG: 00230+3.1.4.53;Reactome: R-HSA-180024	"Purine metabolism";"DARPP-32 events"
XP_046421677.1	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
XP_046433133.1	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
XP_046421030.1	6	KEGG: 00073+1.2.1.84;MetaCyc: PWY-7656;Reactome: R-HSA-9640463;MetaCyc: PWY-6733;MetaCyc: PWY-7782;MetaCyc: PWY-5884	"Cutin, suberine and wax biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Wax biosynthesis";"Sporopollenin precursors biosynthesis";"Plasmalogen biosynthesis";"Wax esters biosynthesis I"
XP_046427051.1	2	Reactome: R-HSA-6782315;MetaCyc: PWY-6829	"tRNA modification in the nucleus and cytosol";"Trna methylation (yeast)"
XP_046418962.1	2	KEGG: 04660+2.7.10.2;Reactome: R-HSA-1433557	"T cell receptor signaling pathway";"Signaling by SCF-KIT"
XP_046432335.1	7	Reactome: R-HSA-380320;Reactome: R-HSA-380270;Reactome: R-HSA-2565942;Reactome: R-HSA-8854518;Reactome: R-HSA-380259;Reactome: R-HSA-380284;Reactome: R-HSA-5620912	"Recruitment of NuMA to mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes";"Regulation of PLK1 Activity at G2/M Transition";"AURKA Activation by TPX2";"Loss of Nlp from mitotic centrosomes";"Loss of proteins required for interphase microtubule organization from the centrosome";"Anchoring of the basal body to the plasma membrane"
XP_046426081.1	2	MetaCyc: PWY-4261;KEGG: 00561+2.7.1.30	"Glycerol degradation I";"Glycerolipid metabolism"
XP_046435151.1	7	Reactome: R-HSA-380284;Reactome: R-HSA-5620912;Reactome: R-HSA-380270;Reactome: R-HSA-2565942;Reactome: R-HSA-380320;Reactome: R-HSA-380259;Reactome: R-HSA-8854518	"Loss of proteins required for interphase microtubule organization from the centrosome";"Anchoring of the basal body to the plasma membrane";"Recruitment of mitotic centrosome proteins and complexes";"Regulation of PLK1 Activity at G2/M Transition";"Recruitment of NuMA to mitotic centrosomes";"Loss of Nlp from mitotic centrosomes";"AURKA Activation by TPX2"
XP_046413228.1	1	Reactome: R-HSA-70221	"Glycogen breakdown (glycogenolysis)"
XP_046426496.1	7	KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04926+2.7.11.1	"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Thermogenesis";"Human cytomegalovirus infection";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Relaxin signaling pathway"
XP_046436327.1	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
XP_046433471.1	2	Reactome: R-HSA-8964038;Reactome: R-HSA-6798695	"LDL clearance";"Neutrophil degranulation"
XP_046413632.1	1	KEGG: 00970+6.3.5.7	"Aminoacyl-tRNA biosynthesis"
XP_046425043.1	10	Reactome: R-HSA-6798695;Reactome: R-HSA-2160916;KEGG: 00600+3.2.1.23;MetaCyc: PWY-6807;KEGG: 00604+3.2.1.23;KEGG: 00531+3.2.1.23;Reactome: R-HSA-2024096;KEGG: 00511+3.2.1.23;Reactome: R-HSA-2206292;KEGG: 00052+3.2.1.23	"Neutrophil degranulation";"Hyaluronan uptake and degradation";"Sphingolipid metabolism";"Xyloglucan degradation II (exoglucanase)";"Glycosphingolipid biosynthesis - ganglio series";"Glycosaminoglycan degradation";"HS-GAG degradation";"Other glycan degradation";"MPS VII - Sly syndrome";"Galactose metabolism"
XP_046418390.1	1	Reactome: R-HSA-204005	"COPII-mediated vesicle transport"
XP_046431163.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_046411739.1	1	KEGG: 00480+3.4.11.2	"Glutathione metabolism"
XP_046429085.1	13	MetaCyc: PWY-7102;MetaCyc: PWY-6859;MetaCyc: PWY-7410;MetaCyc: PWY-7182;MetaCyc: PWY-7141;MetaCyc: PWY-5122;MetaCyc: PWY-7721;MetaCyc: PWY-7736;MetaCyc: PWY-5123;KEGG: 00900+2.5.1.10+2.5.1.1;MetaCyc: PWY-7709;MetaCyc: PWY-6383;MetaCyc: PWY-7659	"Bisabolene biosynthesis (engineered)";"All-trans-farnesol biosynthesis";"Ipsdienol biosynthesis";"Linalool biosynthesis I";"(3S)-linalool biosynthesis";"Geranyl diphosphate biosynthesis";"Methyl phomopsenoate biosynthesis";"Stellatic acid biosynthesis";"Trans, trans-farnesyl diphosphate biosynthesis";"Terpenoid backbone biosynthesis";"(3R)-linalool biosynthesis";"Mono-trans, poly-cis decaprenyl phosphate biosynthesis";"Viridicatumtoxin biosynthesis"
XP_046412475.1	4	KEGG: 00260+1.2.1.8+1.1.99.1;Reactome: R-HSA-6798163;MetaCyc: PWY-3722;MetaCyc: PWY-7494	"Glycine, serine and threonine metabolism";"Choline catabolism";"Glycine betaine biosynthesis II (Gram-positive bacteria)";"Choline degradation IV"
XP_046431804.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046423832.1	1	KEGG: 00051+4.2.1.68	"Fructose and mannose metabolism"
XP_046410643.1	1	Reactome: R-HSA-8949664	"Processing of SMDT1"
XP_046426479.1	1	MetaCyc: PWY-6308	"L-cysteine biosynthesis II (tRNA-dependent)"
XP_046434603.1	57	Reactome: R-HSA-6798695;Reactome: R-HSA-5607761;Reactome: R-HSA-983168;Reactome: R-HSA-5658442;Reactome: R-HSA-2467813;Reactome: R-HSA-174154;Reactome: R-HSA-174184;Reactome: R-HSA-8939902;Reactome: R-HSA-1236978;Reactome: R-HSA-4608870;Reactome: R-HSA-4641257;Reactome: R-HSA-202424;Reactome: R-HSA-75815;Reactome: R-HSA-8951664;Reactome: R-HSA-174084;Reactome: R-HSA-5689880;Reactome: R-HSA-349425;Reactome: R-HSA-8939236;Reactome: R-HSA-5678895;Reactome: R-HSA-180585;Reactome: R-HSA-5610785;Reactome: R-HSA-5668541;Reactome: R-HSA-8941858;Reactome: R-HSA-350562;Reactome: R-HSA-9010553;Reactome: R-HSA-1236974;Reactome: R-HSA-5610780;Reactome: R-HSA-450408;Reactome: R-HSA-5632684;Reactome: R-HSA-4641258;Reactome: R-HSA-211733;Reactome: R-HSA-68949;Reactome: R-HSA-1169091;Reactome: R-HSA-382556;Reactome: R-HSA-174178;Reactome: R-HSA-2871837;Reactome: R-HSA-195253;Reactome: R-HSA-69601;Reactome: R-HSA-5358346;Reactome: R-HSA-69017;Reactome: R-HSA-5676590;Reactome: R-HSA-9604323;Reactome: R-HSA-5362768;Reactome: R-HSA-174113;Reactome: R-HSA-5687128;Reactome: R-HSA-9020702;Reactome: R-HSA-8854050;Reactome: R-HSA-1234176;Reactome: R-HSA-8948751;Reactome: R-HSA-69481;Reactome: R-HSA-8852276;Reactome: R-HSA-5610783;Reactome: R-HSA-5689603;Reactome: R-HSA-68827;Reactome: R-HSA-5607764;Reactome: R-HSA-180534;Reactome: R-HSA-187577	"Neutrophil degranulation";"Dectin-1 mediated noncanonical NF-kB signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Regulation of RAS by GAPs";"Separation of Sister Chromatids";"APC/C:Cdc20 mediated degradation of Securin";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Regulation of RUNX2 expression and activity";"Cross-presentation of soluble exogenous antigens (endosomes)";"Asymmetric localization of PCP proteins";"Degradation of AXIN";"Downstream TCR signaling";"Ubiquitin-dependent degradation of Cyclin D";"Neddylation";"Autodegradation of Cdh1 by Cdh1:APC/C";"Ub-specific processing proteases";"Autodegradation of the E3 ubiquitin ligase COP1";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Defective CFTR causes cystic fibrosis";"Vif-mediated degradation of APOBEC3G";"GLI3 is processed to GLI3R by the proteasome";"TNFR2 non-canonical NF-kB pathway";"Regulation of RUNX3 expression and activity";"Regulation of ornithine decarboxylase (ODC)";"Regulation of expression of SLITs and ROBOs";"ER-Phagosome pathway";"Degradation of GLI1 by the proteasome";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Hedgehog 'on' state";"Degradation of DVL";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Orc1 removal from chromatin";"Activation of NF-kappaB in B cells";"ABC-family proteins mediated transport";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"FCERI mediated NF-kB activation";"Degradation of beta-catenin by the destruction complex";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Hedgehog ligand biogenesis";"CDK-mediated phosphorylation and removal of Cdc6";"NIK-->noncanonical NF-kB signaling";"Negative regulation of NOTCH4 signaling";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"SCF-beta-TrCP mediated degradation of Emi1";"MAPK6/MAPK4 signaling";"Interleukin-1 signaling";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of PTEN stability and activity";"G2/M Checkpoints";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Degradation of GLI2 by the proteasome";"UCH proteinases";"CDT1 association with the CDC6:ORC:origin complex";"CLEC7A (Dectin-1) signaling";"Vpu mediated degradation of CD4";"SCF(Skp2)-mediated degradation of p27/p21"
XP_046423784.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_046417345.1	2	Reactome: R-HSA-8936459;Reactome: R-HSA-3214841	"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"PKMTs methylate histone lysines"
XP_046421871.1	7	KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1	"Thermogenesis";"Human cytomegalovirus infection";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Relaxin signaling pathway";"mTOR signaling pathway";"PI3K-Akt signaling pathway"
XP_046435267.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_046424268.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_046413132.1	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276	"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination"
XP_046428418.1	7	KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1	"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Thermogenesis";"Human cytomegalovirus infection";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Relaxin signaling pathway"
XP_046423350.1	2	Reactome: R-HSA-180024;KEGG: 00230+3.1.4.53	"DARPP-32 events";"Purine metabolism"
XP_046436052.1	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
XP_046435789.1	2	Reactome: R-HSA-5576893;Reactome: R-HSA-5576892	"Phase 2 - plateau phase";"Phase 0 - rapid depolarisation"
XP_046414783.1	14	MetaCyc: PWY-2201;MetaCyc: PWY-1622;KEGG: 00630+2.1.2.1;KEGG: 00460+2.1.2.1;MetaCyc: PWY-5497;MetaCyc: PWY-2161;KEGG: 00260+2.1.2.1;MetaCyc: PWY-3661;MetaCyc: PWY-3841;KEGG: 00680+2.1.2.1;MetaCyc: PWY-3661-1;KEGG: 00670+2.1.2.1;Reactome: R-HSA-196757;MetaCyc: PWY-181	"Folate transformations I";"Formaldehyde assimilation I (serine pathway)";"Glyoxylate and dicarboxylate metabolism";"Cyanoamino acid metabolism";"Purine nucleobases degradation II (anaerobic)";"Folate polyglutamylation";"Glycine, serine and threonine metabolism";"Glycine betaine degradation I";"Folate transformations II (plants)";"Methane metabolism";"Glycine betaine degradation II (mammalian)";"One carbon pool by folate";"Metabolism of folate and pterines";"Photorespiration "
XP_046426038.1	1	Reactome: R-HSA-6784531	"tRNA processing in the nucleus"
XP_046435515.1	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
XP_046430249.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046430858.1	4	Reactome: R-HSA-196741;Reactome: R-HSA-3359463;Reactome: R-HSA-3359462;Reactome: R-HSA-8964011	"Cobalamin (Cbl, vitamin B12) transport and metabolism";"Defective CUBN causes hereditary megaloblastic anemia 1";"Defective AMN causes hereditary megaloblastic anemia 1";"HDL clearance"
XP_046428801.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_046436197.1	17	Reactome: R-HSA-975163;Reactome: R-HSA-937072;Reactome: R-HSA-9014325;Reactome: R-HSA-1169091;Reactome: R-HSA-2871837;Reactome: R-HSA-5689880;Reactome: R-HSA-450321;Reactome: R-HSA-937042;Reactome: R-HSA-9020702;Reactome: R-HSA-9645460;Reactome: R-HSA-202424;Reactome: R-HSA-168638;Reactome: R-HSA-4086398;Reactome: R-HSA-5357956;Reactome: R-HSA-445989;Reactome: R-HSA-5607764;Reactome: R-HSA-450302	"IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation";"TRAF6-mediated induction of TAK1 complex within TLR4 complex";"TICAM1,TRAF6-dependent induction of TAK1 complex";"Activation of NF-kappaB in B cells";"FCERI mediated NF-kB activation";"Ub-specific processing proteases";"JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1";"IRAK2 mediated activation of TAK1 complex";"Interleukin-1 signaling";"Alpha-protein kinase 1 signaling pathway";"Downstream TCR signaling";"NOD1/2 Signaling Pathway";"Ca2+ pathway";"TNFR1-induced NFkappaB signaling pathway";"TAK1 activates NFkB by phosphorylation and activation of IKKs complex";"CLEC7A (Dectin-1) signaling";"activated TAK1 mediates p38 MAPK activation"
XP_046423761.1	8	Reactome: R-HSA-68867;Reactome: R-HSA-68616;Reactome: R-HSA-113507;Reactome: R-HSA-68689;Reactome: R-HSA-176187;Reactome: R-HSA-68827;Reactome: R-HSA-68949;Reactome: R-HSA-68962	"Assembly of the pre-replicative complex";"Assembly of the ORC complex at the origin of replication";"E2F-enabled inhibition of pre-replication complex formation";"CDC6 association with the ORC:origin complex";"Activation of ATR in response to replication stress";"CDT1 association with the CDC6:ORC:origin complex";"Orc1 removal from chromatin";"Activation of the pre-replicative complex"
XP_046413979.1	8	KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;Reactome: R-HSA-2028269;KEGG: 04150+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1	"Thermogenesis";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"PI3K-Akt signaling pathway";"Signaling by Hippo";"mTOR signaling pathway";"Human cytomegalovirus infection";"Relaxin signaling pathway"
XP_046421999.1	2	Reactome: R-HSA-418457;Reactome: R-HSA-1296052	"cGMP effects";"Ca2+ activated K+ channels"
XP_046423419.1	1	Reactome: R-HSA-4551638	"SUMOylation of chromatin organization proteins"
XP_046422256.1	6	Reactome: R-HSA-418597;Reactome: R-HSA-5099900;KEGG: 04070+2.7.11.13;Reactome: R-HSA-76005;Reactome: R-HSA-114516;Reactome: R-HSA-416993	"G alpha (z) signalling events";"WNT5A-dependent internalization of FZD4";"Phosphatidylinositol signaling system";"Response to elevated platelet cytosolic Ca2+";"Disinhibition of SNARE formation";"Trafficking of GluR2-containing AMPA receptors"
XP_046415856.1	7	Reactome: R-HSA-1474151;KEGG: 00790+1.5.1.3;KEGG: 00670+1.5.1.3;Reactome: R-HSA-69205;Reactome: R-HSA-196757;MetaCyc: PWY-6614;MetaCyc: PWY-3841	"Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation";"Folate biosynthesis";"One carbon pool by folate";"G1/S-Specific Transcription";"Metabolism of folate and pterines";"Tetrahydrofolate biosynthesis";"Folate transformations II (plants)"
XP_046420327.1	7	MetaCyc: PWY-5466;MetaCyc: PWY-5469;MetaCyc: PWY-5461;MetaCyc: PWY-7445;KEGG: 00940+1.11.1.7;MetaCyc: PWY-7214;MetaCyc: PWY-6824	"Matairesinol biosynthesis";"Sesamin biosynthesis";"Betanidin degradation";"Luteolin triglucuronide degradation";"Phenylpropanoid biosynthesis";"Baicalein degradation (hydrogen peroxide detoxification)";"Justicidin B biosynthesis"
XP_046413059.1	2	Reactome: R-HSA-389661;Reactome: R-HSA-6783984	"Glyoxylate metabolism and glycine degradation";"Glycine degradation"
XP_046421620.1	3	Reactome: R-HSA-1855167;MetaCyc: PWY-6369;KEGG: 04070+2.7.4.24+2.7.4.21	"Synthesis of pyrophosphates in the cytosol";"Inositol diphosphates biosynthesis";"Phosphatidylinositol signaling system"
XP_046427720.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_046410976.1	1	Reactome: R-HSA-5576886	"Phase 4 - resting membrane potential"
XP_046422327.1	1	Reactome: R-HSA-5663220	"RHO GTPases Activate Formins"
XP_046429771.1	3	Reactome: R-HSA-73856;Reactome: R-HSA-77588;Reactome: R-HSA-159230	"RNA Polymerase II Transcription Termination";"SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs";"Transport of the SLBP Dependant Mature mRNA"
XP_046411350.1	3	Reactome: R-HSA-72163;Reactome: R-HSA-191859;Reactome: R-HSA-72165	"mRNA Splicing - Major Pathway";"snRNP Assembly";"mRNA Splicing - Minor Pathway"
XP_046430974.1	1	Reactome: R-HSA-420029	"Tight junction interactions"
XP_046415294.1	5	Reactome: R-HSA-5696400;Reactome: R-HSA-5685938;Reactome: R-HSA-6782135;Reactome: R-HSA-6783310;Reactome: R-HSA-5696395	"Dual Incision in GG-NER";"HDR through Single Strand Annealing (SSA)";"Dual incision in TC-NER";"Fanconi Anemia Pathway";"Formation of Incision Complex in GG-NER"
XP_046412670.1	7	Reactome: R-HSA-5620912;Reactome: R-HSA-380284;Reactome: R-HSA-380259;Reactome: R-HSA-8854518;Reactome: R-HSA-2565942;Reactome: R-HSA-380270;Reactome: R-HSA-380320	"Anchoring of the basal body to the plasma membrane";"Loss of proteins required for interphase microtubule organization from the centrosome";"Loss of Nlp from mitotic centrosomes";"AURKA Activation by TPX2";"Regulation of PLK1 Activity at G2/M Transition";"Recruitment of mitotic centrosome proteins and complexes";"Recruitment of NuMA to mitotic centrosomes"
XP_046413277.1	16	Reactome: R-HSA-2559580;Reactome: R-HSA-426496;Reactome: R-HSA-9029569;Reactome: R-HSA-5687128;Reactome: R-HSA-8853884;Reactome: R-HSA-9022692;Reactome: R-HSA-4086398;Reactome: R-HSA-8934593;Reactome: R-HSA-8948700;Reactome: R-HSA-5628897;Reactome: R-HSA-2559585;Reactome: R-HSA-8986944;Reactome: R-HSA-8943723;Reactome: R-HSA-1912408;Reactome: R-HSA-8936459;Reactome: R-HSA-9018519	"Oxidative Stress Induced Senescence";"Post-transcriptional silencing by small RNAs";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"MAPK6/MAPK4 signaling";"Transcriptional Regulation by VENTX";"Regulation of MECP2 expression and activity";"Ca2+ pathway";"Regulation of RUNX1 Expression and Activity";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"TP53 Regulates Metabolic Genes";"Oncogene Induced Senescence";"Transcriptional Regulation by MECP2";"Regulation of PTEN mRNA translation";"Pre-NOTCH Transcription and Translation";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Estrogen-dependent gene expression"
XP_046422391.1	1	Reactome: R-HSA-606279	"Deposition of new CENPA-containing nucleosomes at the centromere"
XP_046413587.1	10	KEGG: 00680+2.7.1.11;MetaCyc: PWY-7385;MetaCyc: PWY-1042;MetaCyc: PWY-1861;Reactome: R-HSA-70171;KEGG: 00010+2.7.1.11;MetaCyc: PWY-5484;KEGG: 00052+2.7.1.11;KEGG: 00051+2.7.1.11;KEGG: 00030+2.7.1.11	"Methane metabolism";"1,3-propanediol biosynthesis (engineered)";"Glycolysis IV (plant cytosol)";"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"Glycolysis";"Glycolysis / Gluconeogenesis";"Glycolysis II (from fructose 6-phosphate)";"Galactose metabolism";"Fructose and mannose metabolism";"Pentose phosphate pathway"
XP_046421714.1	1	Reactome: R-HSA-425410	"Metal ion SLC transporters"
XP_046436434.1	5	Reactome: R-HSA-2871796;KEGG: 04150+2.7.11.24;Reactome: R-HSA-2559580;Reactome: R-HSA-450321;Reactome: R-HSA-450341	"FCERI mediated MAPK activation";"mTOR signaling pathway";"Oxidative Stress Induced Senescence";"JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1";"Activation of the AP-1 family of transcription factors"
XP_046413958.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046422170.1	1	Reactome: R-HSA-5576886	"Phase 4 - resting membrane potential"
XP_046433681.1	1	Reactome: R-HSA-69273	"Cyclin A/B1/B2 associated events during G2/M transition"
XP_046420905.1	2	Reactome: R-HSA-3214841;Reactome: R-HSA-8936459	"PKMTs methylate histone lysines";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"
XP_046419986.1	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
XP_046428844.1	1	Reactome: R-HSA-6799198	"Complex I biogenesis"
XP_046409730.1	2	Reactome: R-HSA-983231;Reactome: R-HSA-383280	"Factors involved in megakaryocyte development and platelet production";"Nuclear Receptor transcription pathway"
XP_046413164.1	5	Reactome: R-HSA-389661;KEGG: 00020+1.2.4.2;MetaCyc: PWY-5084;KEGG: 00380+1.2.4.2;KEGG: 00310+1.2.4.2	"Glyoxylate metabolism and glycine degradation";"Citrate cycle (TCA cycle)";"2-oxoglutarate decarboxylation to succinyl-CoA";"Tryptophan metabolism";"Lysine degradation"
XP_046425360.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_046410013.1	1	Reactome: R-HSA-2022928	"HS-GAG biosynthesis"
XP_046413980.1	8	KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;Reactome: R-HSA-2028269;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1	"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Signaling by Hippo";"Human cytomegalovirus infection";"Relaxin signaling pathway";"Thermogenesis";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection"
XP_046431723.1	3	Reactome: R-HSA-6811434;Reactome: R-HSA-6807878;Reactome: R-HSA-6798695	"COPI-dependent Golgi-to-ER retrograde traffic";"COPI-mediated anterograde transport";"Neutrophil degranulation"
XP_046420021.1	19	Reactome: R-HSA-9609736;Reactome: R-HSA-399719;Reactome: R-HSA-5578775;Reactome: R-HSA-936837;Reactome: R-HSA-5576892;Reactome: R-HSA-877300;Reactome: R-HSA-9617324;Reactome: R-HSA-438066;Reactome: R-HSA-9022692;Reactome: R-HSA-111932;Reactome: R-HSA-3371571;Reactome: R-HSA-9649948;Reactome: R-HSA-6802952;Reactome: R-HSA-442982;Reactome: R-HSA-6802955;Reactome: R-HSA-5673000;Reactome: R-HSA-6802946;Reactome: R-HSA-9620244;Reactome: R-HSA-5673001	"Assembly and cell surface presentation of NMDA receptors";"Trafficking of AMPA receptors";"Ion homeostasis";"Ion transport by P-type ATPases";"Phase 0 - rapid depolarisation";"Interferon gamma signaling";"Negative regulation of NMDA receptor-mediated neuronal transmission";"Unblocking of NMDA receptors, glutamate binding and activation";"Regulation of MECP2 expression and activity";"CaMK IV-mediated phosphorylation of CREB";"HSF1-dependent transactivation";"Signaling downstream of RAS mutants";"Signaling by BRAF and RAF fusions";"Ras activation upon Ca2+ influx through NMDA receptor";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"RAF activation";"Signaling by moderate kinase activity BRAF mutants";"Long-term potentiation";"RAF/MAP kinase cascade"
XP_046425348.1	1	Reactome: R-HSA-390648	"Muscarinic acetylcholine receptors"
XP_046428270.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046418389.1	1	Reactome: R-HSA-204005	"COPII-mediated vesicle transport"
XP_046430225.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_046430230.1	10	KEGG: 00332+1.2.1.41+2.7.2.11;MetaCyc: PWY-6922;KEGG: 00332+1.2.1.41;KEGG: 00330+1.2.1.41+2.7.2.11;KEGG: 00330+2.7.2.11+1.2.1.41;KEGG: 00332+2.7.2.11;KEGG: 00330+1.2.1.41;Reactome: R-HSA-8964539;KEGG: 00332+2.7.2.11+1.2.1.41;KEGG: 00330+2.7.2.11	"Carbapenem biosynthesis";"L-Ndelta-acetylornithine biosynthesis";"Carbapenem biosynthesis";"Arginine and proline metabolism";"Arginine and proline metabolism";"Carbapenem biosynthesis";"Arginine and proline metabolism";"Glutamate and glutamine metabolism";"Carbapenem biosynthesis";"Arginine and proline metabolism"
XP_046435561.1	6	Reactome: R-HSA-5632928;Reactome: R-HSA-6796648;Reactome: R-HSA-5358565;Reactome: R-HSA-5632968;Reactome: R-HSA-5358606;Reactome: R-HSA-5632927	"Defective Mismatch Repair Associated With MSH2";"TP53 Regulates Transcription of DNA Repair Genes";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"Defective Mismatch Repair Associated With MSH6";"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"Defective Mismatch Repair Associated With MSH3"
XP_046412295.1	4	KEGG: 00600+3.5.1.23;Reactome: R-HSA-1660662;MetaCyc: PWY-7119;MetaCyc: PWY-6483	"Sphingolipid metabolism";"Glycosphingolipid metabolism";"Ceramide and sphingolipid recycling and degradation (yeast)";"Ceramide degradation (generic)"
XP_046410809.1	2	Reactome: R-HSA-1483166;Reactome: R-HSA-1483148	"Synthesis of PA";"Synthesis of PG"
XP_046412233.1	1	Reactome: R-HSA-8866654	"E3 ubiquitin ligases ubiquitinate target proteins"
XP_046422322.1	6	Reactome: R-HSA-73856;Reactome: R-HSA-975957;Reactome: R-HSA-72163;Reactome: R-HSA-72187;Reactome: R-HSA-159236;Reactome: R-HSA-9010553	"RNA Polymerase II Transcription Termination";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"mRNA Splicing - Major Pathway";"mRNA 3'-end processing";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Regulation of expression of SLITs and ROBOs"
XP_046426754.1	1	Reactome: R-HSA-110320	"Translesion Synthesis by POLH"
XP_046423850.1	1	Reactome: R-HSA-71384	"Ethanol oxidation"
XP_046414119.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_046412790.1	1	Reactome: R-HSA-380972	"Energy dependent regulation of mTOR by LKB1-AMPK"
XP_046422252.1	6	Reactome: R-HSA-114516;Reactome: R-HSA-416993;Reactome: R-HSA-76005;KEGG: 04070+2.7.11.13;Reactome: R-HSA-418597;Reactome: R-HSA-5099900	"Disinhibition of SNARE formation";"Trafficking of GluR2-containing AMPA receptors";"Response to elevated platelet cytosolic Ca2+";"Phosphatidylinositol signaling system";"G alpha (z) signalling events";"WNT5A-dependent internalization of FZD4"
XP_046418398.1	1	Reactome: R-HSA-204005	"COPII-mediated vesicle transport"
XP_046426147.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046424466.1	1	Reactome: R-HSA-1483148	"Synthesis of PG"
XP_046410975.1	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
XP_046426362.1	8	Reactome: R-HSA-6798695;Reactome: R-HSA-74217;MetaCyc: PWY-7179;MetaCyc: PWY-6609;KEGG: 00230+3.5.4.4;MetaCyc: PWY-6611;Reactome: R-HSA-5683826;MetaCyc: PWY-7179-1	"Neutrophil degranulation";"Purine salvage";"Purine deoxyribonucleosides degradation I";"Adenine and adenosine salvage III";"Purine metabolism";"Adenine and adenosine salvage V";"Surfactant metabolism";"Purine deoxyribonucleosides degradation II"
XP_046429729.1	7	Reactome: R-HSA-5083629;Reactome: R-HSA-5173105;Reactome: R-HSA-9010553;Reactome: R-HSA-5083633;Reactome: R-HSA-3000171;Reactome: R-HSA-3000178;Reactome: R-HSA-5083628	"Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2";"O-linked glycosylation";"Regulation of expression of SLITs and ROBOs";"Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1";"Non-integrin membrane-ECM interactions";"ECM proteoglycans";"Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3"
XP_046428480.1	6	Reactome: R-HSA-1655829;Reactome: R-HSA-8874211;Reactome: R-HSA-8963889;Reactome: R-HSA-8957275;Reactome: R-HSA-381426;Reactome: R-HSA-381033	"Regulation of cholesterol biosynthesis by SREBP (SREBF)";"CREB3 factors activate genes";"Assembly of active LPL and LIPC lipase complexes";"Post-translational protein phosphorylation";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"ATF6 (ATF6-alpha) activates chaperones"
XP_046425473.1	3	Reactome: R-HSA-112311;Reactome: R-HSA-422085;Reactome: R-HSA-1483191	"Neurotransmitter clearance";"Synthesis, secretion, and deacylation of Ghrelin";"Synthesis of PC"
XP_046419077.1	4	Reactome: R-HSA-72731;MetaCyc: PWY-4361;MetaCyc: PWY-7174;KEGG: 00270+5.3.1.23	"Recycling of eIF2:GDP";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation II";"Cysteine and methionine metabolism"
XP_046410260.1	2	Reactome: R-HSA-5678895;Reactome: R-HSA-382556	"Defective CFTR causes cystic fibrosis";"ABC-family proteins mediated transport"
XP_046424083.1	1	Reactome: R-HSA-5676934	"Protein repair"
XP_046435768.1	16	Reactome: R-HSA-72764;Reactome: R-HSA-72649;Reactome: R-HSA-156902;Reactome: R-HSA-975957;Reactome: R-HSA-1799339;Reactome: R-HSA-72695;Reactome: R-HSA-192823;Reactome: R-HSA-72689;Reactome: R-HSA-975956;Reactome: R-HSA-72702;Reactome: R-HSA-6791226;Reactome: R-HSA-2408557;Reactome: R-HSA-72706;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-9633012	"Eukaryotic Translation Termination";"Translation initiation complex formation";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"Formation of the ternary complex, and subsequently, the 43S complex";"Viral mRNA Translation";"Formation of a pool of free 40S subunits";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Ribosomal scanning and start codon recognition";"Major pathway of rRNA processing in the nucleolus and cytosol";"Selenocysteine synthesis";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency"
XP_046413767.1	27	Reactome: R-HSA-168271;Reactome: R-HSA-159227;Reactome: R-HSA-168333;Reactome: R-HSA-168276;Reactome: R-HSA-3301854;Reactome: R-HSA-5619107;Reactome: R-HSA-159230;Reactome: R-HSA-180746;Reactome: R-HSA-5578749;Reactome: R-HSA-191859;Reactome: R-HSA-4615885;Reactome: R-HSA-3232142;Reactome: R-HSA-170822;Reactome: R-HSA-180910;Reactome: R-HSA-3371453;Reactome: R-HSA-4551638;Reactome: R-HSA-165054;Reactome: R-HSA-4085377;Reactome: R-HSA-6784531;Reactome: R-HSA-4570464;Reactome: R-HSA-9610379;Reactome: R-HSA-159236;Reactome: R-HSA-9609690;Reactome: R-HSA-1169408;Reactome: R-HSA-159231;Reactome: R-HSA-168325;Reactome: R-HSA-3108214	"Transport of Ribonucleoproteins into the Host Nucleus";"Transport of the SLBP independent Mature mRNA";"NEP/NS2 Interacts with the Cellular Export Machinery";"NS1 Mediated Effects on Host Pathways";"Nuclear Pore Complex (NPC) Disassembly";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Transport of the SLBP Dependant Mature mRNA";"Nuclear import of Rev protein";"Transcriptional regulation by small RNAs";"snRNP Assembly";"SUMOylation of DNA replication proteins";"SUMOylation of ubiquitinylation proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Vpr-mediated nuclear import of PICs";"Regulation of HSF1-mediated heat shock response";"SUMOylation of chromatin organization proteins";"Rev-mediated nuclear export of HIV RNA";"SUMOylation of SUMOylation proteins";"tRNA processing in the nucleus";"SUMOylation of RNA binding proteins";"HCMV Late Events";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"HCMV Early Events";"ISG15 antiviral mechanism";"Transport of Mature mRNA Derived from an Intronless Transcript";"Viral Messenger RNA Synthesis";"SUMOylation of DNA damage response and repair proteins"
XP_046432446.1	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
XP_046430642.1	13	Reactome: R-HSA-1799339;Reactome: R-HSA-72706;Reactome: R-HSA-2408557;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-192823;Reactome: R-HSA-9633012;Reactome: R-HSA-72689;Reactome: R-HSA-72764;Reactome: R-HSA-156902;Reactome: R-HSA-975956;Reactome: R-HSA-6791226;Reactome: R-HSA-975957	"SRP-dependent cotranslational protein targeting to membrane";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Selenocysteine synthesis";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Viral mRNA Translation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Formation of a pool of free 40S subunits";"Eukaryotic Translation Termination";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
XP_046429573.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_046424730.1	7	Reactome: R-HSA-3108214;Reactome: R-HSA-2467813;Reactome: R-HSA-2468052;Reactome: R-HSA-1221632;Reactome: R-HSA-9018519;Reactome: R-HSA-2500257;Reactome: R-HSA-2470946	"SUMOylation of DNA damage response and repair proteins";"Separation of Sister Chromatids";"Establishment of Sister Chromatid Cohesion";"Meiotic synapsis";"Estrogen-dependent gene expression";"Resolution of Sister Chromatid Cohesion";"Cohesin Loading onto Chromatin"
XP_046435642.1	1	Reactome: R-HSA-611105	"Respiratory electron transport"
XP_046418725.1	16	Reactome: R-HSA-167290;Reactome: R-HSA-167152;Reactome: R-HSA-674695;Reactome: R-HSA-167200;Reactome: R-HSA-6796648;Reactome: R-HSA-112382;Reactome: R-HSA-9010553;Reactome: R-HSA-167243;Reactome: R-HSA-983168;Reactome: R-HSA-75955;Reactome: R-HSA-1234176;Reactome: R-HSA-167287;Reactome: R-HSA-180585;Reactome: R-HSA-167238;Reactome: R-HSA-167246;Reactome: R-HSA-8951664	"Pausing and recovery of HIV elongation";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Polymerase II Pre-transcription Events";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"TP53 Regulates Transcription of DNA Repair Genes";"Formation of RNA Pol II elongation complex";"Regulation of expression of SLITs and ROBOs";"Tat-mediated HIV elongation arrest and recovery";"Antigen processing: Ubiquitination & Proteasome degradation";"RNA Polymerase II Transcription Elongation";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"HIV elongation arrest and recovery";"Vif-mediated degradation of APOBEC3G";"Pausing and recovery of Tat-mediated HIV elongation";"Tat-mediated elongation of the HIV-1 transcript";"Neddylation"
XP_046420757.1	13	KEGG: 00603+3.2.1.52;KEGG: 00511+3.2.1.52;KEGG: 00604+3.2.1.52;Reactome: R-HSA-2022857;MetaCyc: PWY-7883;Reactome: R-HSA-1660662;Reactome: R-HSA-2024101;KEGG: 00520+3.2.1.52;KEGG: 00531+3.2.1.52;Reactome: R-HSA-2160916;MetaCyc: PWY-7822;KEGG: 00513+3.2.1.52;MetaCyc: PWY-6902	"Glycosphingolipid biosynthesis - globo and isoglobo series";"Other glycan degradation";"Glycosphingolipid biosynthesis - ganglio series";"Keratan sulfate degradation";"Anhydromuropeptides recycling II";"Glycosphingolipid metabolism";"CS/DS degradation";"Amino sugar and nucleotide sugar metabolism";"Glycosaminoglycan degradation";"Hyaluronan uptake and degradation";"Chitin degradation III (Serratia)";"Various types of N-glycan biosynthesis";"Chitin degradation II (Vibrio)"
XP_046425465.1	16	KEGG: 00020+6.2.1.4;KEGG: 00020+6.2.1.5;MetaCyc: PWY-7384;MetaCyc: PWY-5690;Reactome: R-HSA-71403;KEGG: 00660+6.2.1.5;MetaCyc: PWY-5392;MetaCyc: PWY-5913;KEGG: 00640+6.2.1.5;MetaCyc: PWY-5749;KEGG: 00640+6.2.1.4;KEGG: 00720+6.2.1.5;MetaCyc: PWY-5537;MetaCyc: PWY-6969;MetaCyc: PWY-5538;MetaCyc: PWY-6728	"Citrate cycle (TCA cycle)";"Citrate cycle (TCA cycle)";"Anaerobic energy metabolism (invertebrates, mitochondrial)";"TCA cycle II (plants and fungi)";"Citric acid cycle (TCA cycle)";"C5-Branched dibasic acid metabolism";"Reductive TCA cycle II";"Partial TCA cycle (obligate autotrophs)";"Propanoate metabolism";"Itaconate degradation";"Propanoate metabolism";"Carbon fixation pathways in prokaryotes";"Pyruvate fermentation to acetate V";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Pyruvate fermentation to acetate VI";"Methylaspartate cycle"
XP_046423427.1	11	Reactome: R-HSA-9008059;Reactome: R-HSA-909733;Reactome: R-HSA-912694;Reactome: R-HSA-389948;Reactome: R-HSA-114604;Reactome: R-HSA-432142;Reactome: R-HSA-391160;Reactome: R-HSA-388841;Reactome: R-HSA-877312;Reactome: R-HSA-512988;Reactome: R-HSA-210990	"Interleukin-37 signaling";"Interferon alpha/beta signaling";"Regulation of IFNA signaling";"PD-1 signaling";"GPVI-mediated activation cascade";"Platelet sensitization by LDL";"Signal regulatory protein family interactions";"Costimulation by the CD28 family";"Regulation of IFNG signaling";"Interleukin-3, Interleukin-5 and GM-CSF signaling";"PECAM1 interactions"
XP_046431392.1	27	Reactome: R-HSA-5467340;Reactome: R-HSA-8939902;Reactome: R-HSA-5358747;Reactome: R-HSA-198323;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05163+2.7.11.1;Reactome: R-HSA-195253;Reactome: R-HSA-5358752;KEGG: 04926+2.7.11.1;Reactome: R-HSA-5358751;Reactome: R-HSA-3371453;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;Reactome: R-HSA-5610785;Reactome: R-HSA-4641262;Reactome: R-HSA-5339716;Reactome: R-HSA-5250924;Reactome: R-HSA-5610783;Reactome: R-HSA-5674400;Reactome: R-HSA-5467337;Reactome: R-HSA-5467348;Reactome: R-HSA-196299;Reactome: R-HSA-75815;Reactome: R-HSA-5358749;Reactome: R-HSA-399956;KEGG: 05165+2.7.11.1	"AXIN missense mutants destabilize the destruction complex";"Regulation of RUNX2 expression and activity";"S33 mutants of beta-catenin aren't phosphorylated";"AKT phosphorylates targets in the cytosol";"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Human cytomegalovirus infection";"Degradation of beta-catenin by the destruction complex";"T41 mutants of beta-catenin aren't phosphorylated";"Relaxin signaling pathway";"S45 mutants of beta-catenin aren't phosphorylated";"Regulation of HSF1-mediated heat shock response";"Thermogenesis";"Human immunodeficiency virus 1 infection";"GLI3 is processed to GLI3R by the proteasome";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"Misspliced GSK3beta mutants stabilize beta-catenin";"B-WICH complex positively regulates rRNA expression";"Degradation of GLI2 by the proteasome";"Constitutive Signaling by AKT1 E17K in Cancer";"APC truncation mutants have impaired AXIN binding";"Truncations of AMER1 destabilize the destruction complex";"Beta-catenin phosphorylation cascade";"Ubiquitin-dependent degradation of Cyclin D";"S37 mutants of beta-catenin aren't phosphorylated";"CRMPs in Sema3A signaling";"Human papillomavirus infection"
XP_046429356.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_046431397.1	27	Reactome: R-HSA-3371453;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;Reactome: R-HSA-8939902;Reactome: R-HSA-5358747;Reactome: R-HSA-198323;Reactome: R-HSA-5467340;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05163+2.7.11.1;Reactome: R-HSA-195253;Reactome: R-HSA-5358752;KEGG: 04926+2.7.11.1;Reactome: R-HSA-5358751;Reactome: R-HSA-5467337;Reactome: R-HSA-5674400;Reactome: R-HSA-5467348;Reactome: R-HSA-196299;Reactome: R-HSA-5358749;Reactome: R-HSA-75815;Reactome: R-HSA-399956;KEGG: 05165+2.7.11.1;Reactome: R-HSA-5610785;Reactome: R-HSA-4641262;Reactome: R-HSA-5339716;Reactome: R-HSA-5610783;Reactome: R-HSA-5250924	"Regulation of HSF1-mediated heat shock response";"Thermogenesis";"Human immunodeficiency virus 1 infection";"Regulation of RUNX2 expression and activity";"S33 mutants of beta-catenin aren't phosphorylated";"AKT phosphorylates targets in the cytosol";"AXIN missense mutants destabilize the destruction complex";"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Human cytomegalovirus infection";"Degradation of beta-catenin by the destruction complex";"T41 mutants of beta-catenin aren't phosphorylated";"Relaxin signaling pathway";"S45 mutants of beta-catenin aren't phosphorylated";"APC truncation mutants have impaired AXIN binding";"Constitutive Signaling by AKT1 E17K in Cancer";"Truncations of AMER1 destabilize the destruction complex";"Beta-catenin phosphorylation cascade";"S37 mutants of beta-catenin aren't phosphorylated";"Ubiquitin-dependent degradation of Cyclin D";"CRMPs in Sema3A signaling";"Human papillomavirus infection";"GLI3 is processed to GLI3R by the proteasome";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"Misspliced GSK3beta mutants stabilize beta-catenin";"Degradation of GLI2 by the proteasome";"B-WICH complex positively regulates rRNA expression"
XP_046434185.1	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
XP_046427307.1	1	Reactome: R-HSA-5389840	"Mitochondrial translation elongation"
XP_046430997.1	4	Reactome: R-HSA-180024;KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16	"DARPP-32 events";"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
XP_046423912.1	1	Reactome: R-HSA-162658	"Golgi Cisternae Pericentriolar Stack Reorganization"
XP_046429172.1	2	Reactome: R-HSA-1989781;Reactome: R-HSA-381340	"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation"
XP_046414137.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_046433693.1	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
XP_046412881.1	1	KEGG: 00970+6.1.1.3	"Aminoacyl-tRNA biosynthesis"
XP_046426931.1	6	MetaCyc: PWY-5497;MetaCyc: PWY-7442;Reactome: R-HSA-74259;MetaCyc: PWY-6608;MetaCyc: PWY-6606;KEGG: 00230+3.5.4.3	"Purine nucleobases degradation II (anaerobic)";"Drosopterin and aurodrosopterin biosynthesis";"Purine catabolism";"Guanosine nucleotides degradation III";"Guanosine nucleotides degradation II";"Purine metabolism"
XP_046414583.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046433579.1	1	Reactome: R-HSA-429958	"mRNA decay by 3' to 5' exoribonuclease"
XP_046419729.1	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046425722.1	2	Reactome: R-HSA-8854214;Reactome: R-HSA-977225	"TBC/RABGAPs";"Amyloid fiber formation"
XP_046414966.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_046434258.1	3	Reactome: R-HSA-193648;Reactome: R-HSA-194840;Reactome: R-HSA-416482	"NRAGE signals death through JNK";"Rho GTPase cycle";"G alpha (12/13) signalling events"
XP_046419610.1	14	MetaCyc: PWY-7782;MetaCyc: PWY-7589;MetaCyc: PWY-5981;MetaCyc: PWY-8053;MetaCyc: PWY-7417;MetaCyc: PWY-6453;MetaCyc: PWY-8051;KEGG: 00564+2.3.1.51;MetaCyc: PWY-8055;KEGG: 00561+2.3.1.51;MetaCyc: PWY-5667;Reactome: R-HSA-1483166;MetaCyc: PWY-7411;MetaCyc: PWY-7587	"Plasmalogen biosynthesis";"Palmitoleate biosynthesis III (cyanobacteria)";"CDP-diacylglycerol biosynthesis III";"Anandamide biosynthesis II";"Phospholipid remodeling (phosphatidate, yeast)";"Stigma estolide biosynthesis";"Anandamide biosynthesis I";"Glycerophospholipid metabolism";"Palmitoyl ethanolamide biosynthesis";"Glycerolipid metabolism";"CDP-diacylglycerol biosynthesis I";"Synthesis of PA";"Phosphatidate biosynthesis (yeast)";"Oleate biosynthesis III (cyanobacteria)"
XP_046426934.1	6	MetaCyc: PWY-5497;Reactome: R-HSA-74259;MetaCyc: PWY-7442;MetaCyc: PWY-6608;KEGG: 00230+3.5.4.3;MetaCyc: PWY-6606	"Purine nucleobases degradation II (anaerobic)";"Purine catabolism";"Drosopterin and aurodrosopterin biosynthesis";"Guanosine nucleotides degradation III";"Purine metabolism";"Guanosine nucleotides degradation II"
XP_046413905.1	3	KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation"
XP_046414363.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046426656.1	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
XP_046435274.1	6	KEGG: 04070+3.1.3.78;MetaCyc: PWY-6367;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;MetaCyc: PWY-6368;Reactome: R-HSA-5419276	"Phosphatidylinositol signaling system";"D-myo-inositol-5-phosphate metabolism";"Mitochondrial translation elongation";"Mitochondrial translation initiation";"3-phosphoinositide degradation";"Mitochondrial translation termination"
XP_046421392.1	3	Reactome: R-HSA-1474151;KEGG: 00790+1.1.1.153;Reactome: R-HSA-203615	"Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation";"Folate biosynthesis";"eNOS activation"
XP_046421716.1	1	Reactome: R-HSA-425410	"Metal ion SLC transporters"
XP_046418319.1	44	Reactome: R-HSA-9634638;Reactome: R-HSA-9635465;Reactome: R-HSA-2559580;Reactome: R-HSA-456926;Reactome: R-HSA-5675221;Reactome: R-HSA-198753;Reactome: R-HSA-2029482;Reactome: R-HSA-879415;Reactome: R-HSA-3371453;Reactome: R-HSA-8940973;Reactome: R-HSA-881907;Reactome: R-HSA-375165;Reactome: R-HSA-2559585;Reactome: R-HSA-444257;Reactome: R-HSA-6802955;KEGG: 04150+2.7.11.24;Reactome: R-HSA-9627069;Reactome: R-HSA-170968;Reactome: R-HSA-445144;Reactome: R-HSA-162658;Reactome: R-HSA-5654732;Reactome: R-HSA-202670;Reactome: R-HSA-8943724;Reactome: R-HSA-2871796;Reactome: R-HSA-450341;Reactome: R-HSA-6802946;Reactome: R-HSA-5673001;Reactome: R-HSA-74749;Reactome: R-HSA-5654726;Reactome: R-HSA-5674499;Reactome: R-HSA-1295596;Reactome: R-HSA-982772;Reactome: R-HSA-8939211;Reactome: R-HSA-5654727;Reactome: R-HSA-5668599;Reactome: R-HSA-6811558;Reactome: R-HSA-6802952;Reactome: R-HSA-9649948;Reactome: R-HSA-2559582;Reactome: R-HSA-6802948;Reactome: R-HSA-5663213;Reactome: R-HSA-112409;Reactome: R-HSA-5674135;Reactome: R-HSA-5654733	"Estrogen-dependent nuclear events downstream of ESR-membrane signaling";"Suppression of apoptosis";"Oxidative Stress Induced Senescence";"Thrombin signalling through proteinase activated receptors (PARs)";"Negative regulation of MAPK pathway";"ERK/MAPK targets";"Regulation of actin dynamics for phagocytic cup formation";"Advanced glycosylation endproduct receptor signaling";"Regulation of HSF1-mediated heat shock response";"RUNX2 regulates osteoblast differentiation";"Gastrin-CREB signalling pathway via PKC and MAPK";"NCAM signaling for neurite out-growth";"Oncogene Induced Senescence";"RSK activation";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"mTOR signaling pathway";"Regulation of the apoptosome activity";"Frs2-mediated activation";"Signal transduction by L1";"Golgi Cisternae Pericentriolar Stack Reorganization";"Negative regulation of FGFR3 signaling";"ERKs are inactivated";"Regulation of PTEN gene transcription";"FCERI mediated MAPK activation";"Activation of the AP-1 family of transcription factors";"Signaling by moderate kinase activity BRAF mutants";"RAF/MAP kinase cascade";"Signal attenuation";"Negative regulation of FGFR1 signaling";"Negative feedback regulation of MAPK pathway";"Spry regulation of FGF signaling";"Growth hormone receptor signaling";"ESR-mediated signaling";"Negative regulation of FGFR2 signaling";"RHO GTPases Activate NADPH Oxidases";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"Signaling by BRAF and RAF fusions";"Signaling downstream of RAS mutants";"Senescence-Associated Secretory Phenotype (SASP)";"Signaling by high-kinase activity BRAF mutants";"RHO GTPases Activate WASPs and WAVEs";"RAF-independent MAPK1/3 activation";"MAP2K and MAPK activation";"Negative regulation of FGFR4 signaling"
XP_046418991.1	2	KEGG: 04660+2.7.10.2;Reactome: R-HSA-1433557	"T cell receptor signaling pathway";"Signaling by SCF-KIT"
XP_046415610.1	14	MetaCyc: PWY-7589;MetaCyc: PWY-7782;MetaCyc: PWY-8053;MetaCyc: PWY-5981;MetaCyc: PWY-7417;KEGG: 00561+2.3.1.51;MetaCyc: PWY-8055;MetaCyc: PWY-8051;KEGG: 00564+2.3.1.51;MetaCyc: PWY-6453;MetaCyc: PWY-5667;MetaCyc: PWY-7411;Reactome: R-HSA-1483166;MetaCyc: PWY-7587	"Palmitoleate biosynthesis III (cyanobacteria)";"Plasmalogen biosynthesis";"Anandamide biosynthesis II";"CDP-diacylglycerol biosynthesis III";"Phospholipid remodeling (phosphatidate, yeast)";"Glycerolipid metabolism";"Palmitoyl ethanolamide biosynthesis";"Anandamide biosynthesis I";"Glycerophospholipid metabolism";"Stigma estolide biosynthesis";"CDP-diacylglycerol biosynthesis I";"Phosphatidate biosynthesis (yeast)";"Synthesis of PA";"Oleate biosynthesis III (cyanobacteria)"
XP_046409757.1	1	Reactome: R-HSA-6803157	"Antimicrobial peptides"
XP_046413083.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046431855.1	1	Reactome: R-HSA-2995383	"Initiation of Nuclear Envelope Reformation"
XP_046435767.1	1	Reactome: R-HSA-5625900	"RHO GTPases activate CIT"
XP_046420188.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_046418153.1	1	Reactome: R-HSA-1445148	"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
XP_046410510.1	6	MetaCyc: PWY-7817;MetaCyc: PWY-7039;KEGG: 00561+2.7.1.107;KEGG: 04070+2.7.1.107;Reactome: R-HSA-114508;KEGG: 00564+2.7.1.107	"Type I lipoteichoic acid biosynthesis (S. aureus)";"Phosphatidate metabolism, as a signaling molecule";"Glycerolipid metabolism";"Phosphatidylinositol signaling system";"Effects of PIP2 hydrolysis";"Glycerophospholipid metabolism"
XP_046412810.1	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
XP_046435462.1	3	Reactome: R-HSA-1660662;KEGG: 00511+3.2.1.45;KEGG: 00600+3.2.1.45	"Glycosphingolipid metabolism";"Other glycan degradation";"Sphingolipid metabolism"
XP_046415199.1	2	Reactome: R-HSA-383280;Reactome: R-HSA-983231	"Nuclear Receptor transcription pathway";"Factors involved in megakaryocyte development and platelet production"
XP_046432522.1	5	MetaCyc: PWY-6368;MetaCyc: PWY-6580;Reactome: R-HSA-1660499;KEGG: 04070+3.1.3.64;KEGG: 00562+3.1.3.64	"3-phosphoinositide degradation";"Phosphatidylinositol biosynthesis I (bacteria)";"Synthesis of PIPs at the plasma membrane";"Phosphatidylinositol signaling system";"Inositol phosphate metabolism"
XP_046424995.1	1	Reactome: R-HSA-1483101	"Synthesis of PS"
XP_046430152.1	5	MetaCyc: PWY-6855;KEGG: 00520+3.5.99.6;MetaCyc: PWY-6906;MetaCyc: PWY-5514;Reactome: R-HSA-70171	"Chitin degradation I (archaea)";"Amino sugar and nucleotide sugar metabolism";"Chitin derivatives degradation";"UDP-N-acetyl-D-galactosamine biosynthesis II";"Glycolysis"
XP_046435849.1	3	KEGG: 00240+1.3.5.2;MetaCyc: PWY-5686;Reactome: R-HSA-500753	"Pyrimidine metabolism";"UMP biosynthesis I";"Pyrimidine biosynthesis"
XP_046426007.1	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046428712.1	6	KEGG: 04070+2.7.1.107;KEGG: 00564+2.7.1.107;Reactome: R-HSA-114508;MetaCyc: PWY-7817;MetaCyc: PWY-7039;KEGG: 00561+2.7.1.107	"Phosphatidylinositol signaling system";"Glycerophospholipid metabolism";"Effects of PIP2 hydrolysis";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Phosphatidate metabolism, as a signaling molecule";"Glycerolipid metabolism"
XP_046426463.1	3	Reactome: R-HSA-75109;KEGG: 00561+2.7.1.30;MetaCyc: PWY-4261	"Triglyceride biosynthesis";"Glycerolipid metabolism";"Glycerol degradation I"
XP_046410377.1	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
XP_046431505.1	3	Reactome: R-HSA-74217;KEGG: 00230+2.7.1.20;MetaCyc: PWY-6619	"Purine salvage";"Purine metabolism";"Adenine and adenosine salvage VI"
XP_046430059.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_046434887.1	12	MetaCyc: PWY-6672;MetaCyc: PWY-7857;KEGG: 00680+6.2.1.1;MetaCyc: PWY-5133;KEGG: 00640+6.2.1.1;MetaCyc: PWY-7118;MetaCyc: PWY-5132;KEGG: 00620+6.2.1.1;KEGG: 00720+6.2.1.1;KEGG: 00630+6.2.1.1;KEGG: 00010+6.2.1.1;MetaCyc: PWY-5108	"Cis-genanyl-coa degradation";"Adlupulone and adhumulone biosynthesis";"Methane metabolism";"Colupulone and cohumulone biosynthesis";"Propanoate metabolism";"Chitin degradation to ethanol";"Lupulone and humulone biosynthesis";"Pyruvate metabolism";"Carbon fixation pathways in prokaryotes";"Glyoxylate and dicarboxylate metabolism";"Glycolysis / Gluconeogenesis";"L-isoleucine biosynthesis V"
XP_046412369.1	32	Reactome: R-HSA-167290;Reactome: R-HSA-6803529;Reactome: R-HSA-167152;Reactome: R-HSA-674695;Reactome: R-HSA-167242;Reactome: R-HSA-167200;Reactome: R-HSA-77075;Reactome: R-HSA-6796648;Reactome: R-HSA-167172;Reactome: R-HSA-167160;Reactome: R-HSA-73779;Reactome: R-HSA-167238;Reactome: R-HSA-75953;Reactome: R-HSA-167246;Reactome: R-HSA-72165;Reactome: R-HSA-168325;Reactome: R-HSA-167161;Reactome: R-HSA-8851708;Reactome: R-HSA-9018519;Reactome: R-HSA-72086;Reactome: R-HSA-73776;Reactome: R-HSA-112382;Reactome: R-HSA-72163;Reactome: R-HSA-167243;Reactome: R-HSA-72203;Reactome: R-HSA-76042;Reactome: R-HSA-75955;Reactome: R-HSA-167158;Reactome: R-HSA-167287;Reactome: R-HSA-113418;Reactome: R-HSA-167162;Reactome: R-HSA-6807505	"Pausing and recovery of HIV elongation";"FGFR2 alternative splicing";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Polymerase II Pre-transcription Events";"Abortive elongation of HIV-1 transcript in the absence of Tat";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Pol II CTD phosphorylation and interaction with CE";"TP53 Regulates Transcription of DNA Repair Genes";"Transcription of the HIV genome";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Pausing and recovery of Tat-mediated HIV elongation";"RNA Polymerase II Transcription Initiation";"Tat-mediated elongation of the HIV-1 transcript";"mRNA Splicing - Minor Pathway";"Viral Messenger RNA Synthesis";"HIV Transcription Initiation";"Signaling by FGFR2 IIIa TM";"Estrogen-dependent gene expression";"mRNA Capping";"RNA Polymerase II Promoter Escape";"Formation of RNA Pol II elongation complex";"mRNA Splicing - Major Pathway";"Tat-mediated HIV elongation arrest and recovery";"Processing of Capped Intron-Containing Pre-mRNA";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II Transcription Elongation";"Formation of the HIV-1 Early Elongation Complex";"HIV elongation arrest and recovery";"Formation of the Early Elongation Complex";"RNA Polymerase II HIV Promoter Escape";"RNA polymerase II transcribes snRNA genes"
XP_046410074.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-5628897	"Respiratory electron transport";"TP53 Regulates Metabolic Genes"
XP_046435830.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_046427620.1	1	Reactome: R-HSA-3214842	"HDMs demethylate histones"
XP_046433068.1	6	Reactome: R-HSA-8874081;Reactome: R-HSA-1650814;Reactome: R-HSA-3000171;Reactome: R-HSA-2022090;Reactome: R-HSA-8948216;Reactome: R-HSA-1442490	"MET activates PTK2 signaling";"Collagen biosynthesis and modifying enzymes";"Non-integrin membrane-ECM interactions";"Assembly of collagen fibrils and other multimeric structures";"Collagen chain trimerization";"Collagen degradation"
XP_046412848.1	7	Reactome: R-HSA-380320;Reactome: R-HSA-2565942;Reactome: R-HSA-380270;Reactome: R-HSA-8854518;Reactome: R-HSA-380259;Reactome: R-HSA-5620912;Reactome: R-HSA-380284	"Recruitment of NuMA to mitotic centrosomes";"Regulation of PLK1 Activity at G2/M Transition";"Recruitment of mitotic centrosome proteins and complexes";"AURKA Activation by TPX2";"Loss of Nlp from mitotic centrosomes";"Anchoring of the basal body to the plasma membrane";"Loss of proteins required for interphase microtubule organization from the centrosome"
XP_046424775.1	8	Reactome: R-HSA-77387;Reactome: R-HSA-9639288;KEGG: 00195+7.1.2.2;Reactome: R-HSA-1222556;Reactome: R-HSA-917977;MetaCyc: PWY-7980;KEGG: 00190+7.1.2.2;Reactome: R-HSA-983712	"Insulin receptor recycling";"Amino acids regulate mTORC1";"Photosynthesis";"ROS and RNS production in phagocytes";"Transferrin endocytosis and recycling";"ATP biosynthesis";"Oxidative phosphorylation";"Ion channel transport"
XP_046419323.1	1	Reactome: R-HSA-5693565	"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"
XP_046429009.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_046431433.1	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
XP_046418395.1	3	Reactome: R-HSA-193648;Reactome: R-HSA-194840;Reactome: R-HSA-416482	"NRAGE signals death through JNK";"Rho GTPase cycle";"G alpha (12/13) signalling events"
XP_046424427.1	3	Reactome: R-HSA-983189;Reactome: R-HSA-2132295;Reactome: R-HSA-6811434	"Kinesins";"MHC class II antigen presentation";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_046422106.1	1	Reactome: R-HSA-8949613	"Cristae formation"
XP_046420196.1	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
XP_046410789.1	6	Reactome: R-HSA-6791226;Reactome: R-HSA-450385;Reactome: R-HSA-380994;Reactome: R-HSA-429958;Reactome: R-HSA-450604;Reactome: R-HSA-450513	"Major pathway of rRNA processing in the nucleolus and cytosol";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"ATF4 activates genes in response to endoplasmic reticulum stress";"mRNA decay by 3' to 5' exoribonuclease";"KSRP (KHSRP) binds and destabilizes mRNA";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA"
XP_046434578.1	3	Reactome: R-HSA-418597;KEGG: 04070+2.7.11.13;Reactome: R-HSA-114508	"G alpha (z) signalling events";"Phosphatidylinositol signaling system";"Effects of PIP2 hydrolysis"
XP_046411240.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046425856.1	56	Reactome: R-HSA-5676590;Reactome: R-HSA-5362768;Reactome: R-HSA-9604323;Reactome: R-HSA-69601;Reactome: R-HSA-69017;Reactome: R-HSA-5358346;Reactome: R-HSA-195253;Reactome: R-HSA-2871837;Reactome: R-HSA-174178;Reactome: R-HSA-1169091;Reactome: R-HSA-68949;Reactome: R-HSA-382556;Reactome: R-HSA-4641258;Reactome: R-HSA-211733;Reactome: R-HSA-5632684;Reactome: R-HSA-450408;Reactome: R-HSA-5610780;Reactome: R-HSA-1236974;Reactome: R-HSA-350562;Reactome: R-HSA-8941858;Reactome: R-HSA-9010553;Reactome: R-HSA-5668541;Reactome: R-HSA-180534;Reactome: R-HSA-187577;Reactome: R-HSA-5607764;Reactome: R-HSA-68827;Reactome: R-HSA-5689603;Reactome: R-HSA-5610783;Reactome: R-HSA-8852276;Reactome: R-HSA-69481;Reactome: R-HSA-8948751;Reactome: R-HSA-1234176;Reactome: R-HSA-9020702;Reactome: R-HSA-8854050;Reactome: R-HSA-5687128;Reactome: R-HSA-174113;Reactome: R-HSA-8939902;Reactome: R-HSA-174184;Reactome: R-HSA-174154;Reactome: R-HSA-2467813;Reactome: R-HSA-5658442;Reactome: R-HSA-983168;Reactome: R-HSA-5607761;Reactome: R-HSA-5610785;Reactome: R-HSA-180585;Reactome: R-HSA-5678895;Reactome: R-HSA-8939236;Reactome: R-HSA-349425;Reactome: R-HSA-5689880;Reactome: R-HSA-8951664;Reactome: R-HSA-174084;Reactome: R-HSA-202424;Reactome: R-HSA-75815;Reactome: R-HSA-4608870;Reactome: R-HSA-4641257;Reactome: R-HSA-1236978	"NIK-->noncanonical NF-kB signaling";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Negative regulation of NOTCH4 signaling";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"CDK-mediated phosphorylation and removal of Cdc6";"Hedgehog ligand biogenesis";"Degradation of beta-catenin by the destruction complex";"FCERI mediated NF-kB activation";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Activation of NF-kappaB in B cells";"Orc1 removal from chromatin";"ABC-family proteins mediated transport";"Degradation of DVL";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Hedgehog 'on' state";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Degradation of GLI1 by the proteasome";"ER-Phagosome pathway";"Regulation of ornithine decarboxylase (ODC)";"Regulation of RUNX3 expression and activity";"Regulation of expression of SLITs and ROBOs";"TNFR2 non-canonical NF-kB pathway";"Vpu mediated degradation of CD4";"SCF(Skp2)-mediated degradation of p27/p21";"CLEC7A (Dectin-1) signaling";"CDT1 association with the CDC6:ORC:origin complex";"UCH proteinases";"Degradation of GLI2 by the proteasome";"The role of GTSE1 in G2/M progression after G2 checkpoint";"G2/M Checkpoints";"Regulation of PTEN stability and activity";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Interleukin-1 signaling";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"MAPK6/MAPK4 signaling";"SCF-beta-TrCP mediated degradation of Emi1";"Regulation of RUNX2 expression and activity";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"APC/C:Cdc20 mediated degradation of Securin";"Separation of Sister Chromatids";"Regulation of RAS by GAPs";"Antigen processing: Ubiquitination & Proteasome degradation";"Dectin-1 mediated noncanonical NF-kB signaling";"GLI3 is processed to GLI3R by the proteasome";"Vif-mediated degradation of APOBEC3G";"Defective CFTR causes cystic fibrosis";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Autodegradation of the E3 ubiquitin ligase COP1";"Ub-specific processing proteases";"Neddylation";"Autodegradation of Cdh1 by Cdh1:APC/C";"Downstream TCR signaling";"Ubiquitin-dependent degradation of Cyclin D";"Asymmetric localization of PCP proteins";"Degradation of AXIN";"Cross-presentation of soluble exogenous antigens (endosomes)"
XP_046429636.1	16	Reactome: R-HSA-1799339;Reactome: R-HSA-72695;Reactome: R-HSA-192823;Reactome: R-HSA-72689;Reactome: R-HSA-72649;Reactome: R-HSA-72764;Reactome: R-HSA-156902;Reactome: R-HSA-975957;Reactome: R-HSA-72706;Reactome: R-HSA-2408557;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-975956;Reactome: R-HSA-72702;Reactome: R-HSA-6791226	"SRP-dependent cotranslational protein targeting to membrane";"Formation of the ternary complex, and subsequently, the 43S complex";"Viral mRNA Translation";"Formation of a pool of free 40S subunits";"Translation initiation complex formation";"Eukaryotic Translation Termination";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Selenocysteine synthesis";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Ribosomal scanning and start codon recognition";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046420151.1	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
XP_046422503.1	1	Reactome: R-HSA-69231	"Cyclin D associated events in G1"
XP_046428646.1	1	Reactome: R-HSA-525793	"Myogenesis"
XP_046434884.1	12	MetaCyc: PWY-5108;KEGG: 00010+6.2.1.1;KEGG: 00630+6.2.1.1;KEGG: 00720+6.2.1.1;MetaCyc: PWY-5132;KEGG: 00620+6.2.1.1;KEGG: 00640+6.2.1.1;MetaCyc: PWY-7118;KEGG: 00680+6.2.1.1;MetaCyc: PWY-5133;MetaCyc: PWY-6672;MetaCyc: PWY-7857	"L-isoleucine biosynthesis V";"Glycolysis / Gluconeogenesis";"Glyoxylate and dicarboxylate metabolism";"Carbon fixation pathways in prokaryotes";"Lupulone and humulone biosynthesis";"Pyruvate metabolism";"Propanoate metabolism";"Chitin degradation to ethanol";"Methane metabolism";"Colupulone and cohumulone biosynthesis";"Cis-genanyl-coa degradation";"Adlupulone and adhumulone biosynthesis"
XP_046434741.1	2	Reactome: R-HSA-3299685;MetaCyc: PWY-6854	"Detoxification of Reactive Oxygen Species";"Ethylene biosynthesis III (microbes)"
XP_046422613.1	3	Reactome: R-HSA-3322077;KEGG: 00500+2.4.1.11;MetaCyc: PWY-5067	"Glycogen synthesis";"Starch and sucrose metabolism";"Glycogen biosynthesis II (from UDP-D-Glucose)"
XP_046428705.1	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
XP_046412647.1	4	Reactome: R-HSA-350054;Reactome: R-HSA-2644606;Reactome: R-HSA-2894862;Reactome: R-HSA-2122947	"Notch-HLH transcription pathway";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"NOTCH1 Intracellular Domain Regulates Transcription"
XP_046420044.1	3	Reactome: R-HSA-8866654;MetaCyc: PWY-7511;Reactome: R-HSA-110314	"E3 ubiquitin ligases ubiquitinate target proteins";"Protein ubiquitination";"Recognition of DNA damage by PCNA-containing replication complex"
XP_046413651.1	4	MetaCyc: PWY-6829;MetaCyc: PWY-7285;MetaCyc: PWY-7286;Reactome: R-HSA-6782315	"Trna methylation (yeast)";"Methylwyosine biosynthesis";"7-(3-amino-3-carboxypropyl)-wyosine biosynthesis";"tRNA modification in the nucleus and cytosol"
XP_046431685.1	3	Reactome: R-HSA-446193;KEGG: 00510+2.4.1.265;Reactome: R-HSA-4724325	"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"N-Glycan biosynthesis";"Defective ALG8 causes ALG8-CDG (CDG-1h)"
XP_046420020.1	5	Reactome: R-HSA-389960;Reactome: R-HSA-389957;Reactome: R-HSA-390471;Reactome: R-HSA-390450;Reactome: R-HSA-6814122	"Formation of tubulin folding intermediates by CCT/TriC";"Prefoldin mediated transfer of substrate to CCT/TriC";"Association of TriC/CCT with target proteins during biosynthesis";"Folding of actin by CCT/TriC";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"
XP_046420819.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046415689.1	2	Reactome: R-HSA-5576892;Reactome: R-HSA-445095	"Phase 0 - rapid depolarisation";"Interaction between L1 and Ankyrins"
XP_046429230.1	3	Reactome: R-HSA-6798695;Reactome: R-HSA-6807004;Reactome: R-HSA-202427	"Neutrophil degranulation";"Negative regulation of MET activity";"Phosphorylation of CD3 and TCR zeta chains"
XP_046417701.1	1	Reactome: R-HSA-432047	"Passive transport by Aquaporins"
XP_046417742.1	2	Reactome: R-HSA-202733;Reactome: R-HSA-416993	"Cell surface interactions at the vascular wall";"Trafficking of GluR2-containing AMPA receptors"
XP_046423337.1	2	Reactome: R-HSA-180024;KEGG: 00230+3.1.4.53	"DARPP-32 events";"Purine metabolism"
XP_046424480.1	6	MetaCyc: PWY-7782;MetaCyc: PWY-5884;Reactome: R-HSA-9640463;MetaCyc: PWY-6733;KEGG: 00073+1.2.1.84;MetaCyc: PWY-7656	"Plasmalogen biosynthesis";"Wax esters biosynthesis I";"Wax biosynthesis";"Sporopollenin precursors biosynthesis";"Cutin, suberine and wax biosynthesis";"Spodoptera littoralis pheromone biosynthesis"
XP_046415086.1	1	Reactome: R-HSA-2132295	"MHC class II antigen presentation"
XP_046417053.1	2	Reactome: R-HSA-983231;Reactome: R-HSA-383280	"Factors involved in megakaryocyte development and platelet production";"Nuclear Receptor transcription pathway"
XP_046422080.1	3	Reactome: R-HSA-194840;Reactome: R-HSA-416482;Reactome: R-HSA-193648	"Rho GTPase cycle";"G alpha (12/13) signalling events";"NRAGE signals death through JNK"
XP_046420390.1	3	Reactome: R-HSA-8963684;KEGG: 00643+3.7.1.2;KEGG: 00350+3.7.1.2	"Tyrosine catabolism";"Styrene degradation";"Tyrosine metabolism"
XP_046412977.1	14	Reactome: R-HSA-5655862;Reactome: R-HSA-6782210;Reactome: R-HSA-69091;Reactome: R-HSA-5685942;Reactome: R-HSA-5696397;Reactome: R-HSA-110314;Reactome: R-HSA-5656121;Reactome: R-HSA-110312;Reactome: R-HSA-174411;Reactome: R-HSA-5651801;Reactome: R-HSA-6782135;Reactome: R-HSA-110320;Reactome: R-HSA-5696400;Reactome: R-HSA-5656169	"Translesion synthesis by POLK";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Polymerase switching";"HDR through Homologous Recombination (HRR)";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Recognition of DNA damage by PCNA-containing replication complex";"Translesion synthesis by POLI";"Translesion synthesis by REV1";"Polymerase switching on the C-strand of the telomere";"PCNA-Dependent Long Patch Base Excision Repair";"Dual incision in TC-NER";"Translesion Synthesis by POLH";"Dual Incision in GG-NER";"Termination of translesion DNA synthesis"
XP_046422770.1	8	Reactome: R-HSA-113507;Reactome: R-HSA-68689;Reactome: R-HSA-68616;Reactome: R-HSA-68867;Reactome: R-HSA-68962;Reactome: R-HSA-68949;Reactome: R-HSA-68827;Reactome: R-HSA-176187	"E2F-enabled inhibition of pre-replication complex formation";"CDC6 association with the ORC:origin complex";"Assembly of the ORC complex at the origin of replication";"Assembly of the pre-replicative complex";"Activation of the pre-replicative complex";"Orc1 removal from chromatin";"CDT1 association with the CDC6:ORC:origin complex";"Activation of ATR in response to replication stress"
XP_046411084.1	3	Reactome: R-HSA-1989781;Reactome: R-HSA-381340;Reactome: R-HSA-9018519	"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation";"Estrogen-dependent gene expression"
XP_046426073.1	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
XP_046434608.1	10	Reactome: R-HSA-70370;KEGG: 00052+5.1.3.2;KEGG: 00520+5.1.3.2;Reactome: R-HSA-5609977;MetaCyc: PWY-6397;MetaCyc: PWY-3821;MetaCyc: PWY-6317;MetaCyc: PWY-7328;MetaCyc: PWY-6527;MetaCyc: PWY-7344	"Galactose catabolism";"Galactose metabolism";"Amino sugar and nucleotide sugar metabolism";"Defective GALE can cause Epimerase-deficiency galactosemia (EDG)";"Mycolyl-arabinogalactan-peptidoglycan complex biosynthesis";"D-galactose detoxification";"D-galactose degradation I (Leloir pathway)";"Superpathway of UDP-glucose-derived O-antigen building blocks biosynthesis";"Stachyose degradation";"UDP-alpha-D-galactose biosynthesis"
XP_046413596.1	5	Reactome: R-HSA-5625740;Reactome: R-HSA-5628897;Reactome: R-HSA-111447;Reactome: R-HSA-1445148;Reactome: R-HSA-75035	"RHO GTPases activate PKNs";"TP53 Regulates Metabolic Genes";"Activation of BAD and translocation to mitochondria";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex"
XP_046428014.1	3	Reactome: R-HSA-73856;Reactome: R-HSA-159236;Reactome: R-HSA-72187	"RNA Polymerase II Transcription Termination";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"mRNA 3'-end processing"
XP_046430121.1	3	Reactome: R-HSA-193681;Reactome: R-HSA-5626978;Reactome: R-HSA-1660662	"Ceramide signalling";"TNFR1-mediated ceramide production";"Glycosphingolipid metabolism"
XP_046417799.1	5	Reactome: R-HSA-3247509;Reactome: R-HSA-3214858;Reactome: R-HSA-1266695;Reactome: R-HSA-8939243;Reactome: R-HSA-201722	"Chromatin modifying enzymes";"RMTs methylate histone arginines";"Interleukin-7 signaling";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"Formation of the beta-catenin:TCF transactivating complex"
XP_046422853.1	1	Reactome: R-HSA-426048	"Arachidonate production from DAG"
XP_046425415.1	2	Reactome: R-HSA-8856828;Reactome: R-HSA-8856825	"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis"
XP_046428790.1	3	KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16	"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
XP_046428835.1	1	Reactome: R-HSA-191859	"snRNP Assembly"
XP_046431686.1	13	Reactome: R-HSA-2160916;KEGG: 00531+3.2.1.52;MetaCyc: PWY-6902;KEGG: 00513+3.2.1.52;MetaCyc: PWY-7822;Reactome: R-HSA-2024101;KEGG: 00520+3.2.1.52;MetaCyc: PWY-7883;Reactome: R-HSA-2022857;Reactome: R-HSA-1660662;KEGG: 00511+3.2.1.52;KEGG: 00603+3.2.1.52;KEGG: 00604+3.2.1.52	"Hyaluronan uptake and degradation";"Glycosaminoglycan degradation";"Chitin degradation II (Vibrio)";"Various types of N-glycan biosynthesis";"Chitin degradation III (Serratia)";"CS/DS degradation";"Amino sugar and nucleotide sugar metabolism";"Anhydromuropeptides recycling II";"Keratan sulfate degradation";"Glycosphingolipid metabolism";"Other glycan degradation";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Glycosphingolipid biosynthesis - ganglio series"
XP_046413676.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_046415069.1	1	Reactome: R-HSA-1660661	"Sphingolipid de novo biosynthesis"
XP_046432700.1	1	Reactome: R-HSA-381753	"Olfactory Signaling Pathway"
XP_046412359.1	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
XP_046417050.1	2	Reactome: R-HSA-983231;Reactome: R-HSA-383280	"Factors involved in megakaryocyte development and platelet production";"Nuclear Receptor transcription pathway"
XP_046433016.1	7	Reactome: R-HSA-1362300;Reactome: R-HSA-156711;Reactome: R-HSA-69656;Reactome: R-HSA-1538133;Reactome: R-HSA-69202;Reactome: R-HSA-69205;Reactome: R-HSA-1362277	"Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1";"Polo-like kinase mediated events";"Cyclin A:Cdk2-associated events at S phase entry";"G0 and Early G1";"Cyclin E associated events during G1/S transition";"G1/S-Specific Transcription";"Transcription of E2F targets under negative control by DREAM complex"
XP_046431149.1	14	MetaCyc: PWY-7587;MetaCyc: PWY-7411;Reactome: R-HSA-1483166;MetaCyc: PWY-5667;MetaCyc: PWY-8055;KEGG: 00561+2.3.1.51;MetaCyc: PWY-8051;MetaCyc: PWY-6453;KEGG: 00564+2.3.1.51;MetaCyc: PWY-7417;MetaCyc: PWY-5981;MetaCyc: PWY-8053;MetaCyc: PWY-7589;MetaCyc: PWY-7782	"Oleate biosynthesis III (cyanobacteria)";"Phosphatidate biosynthesis (yeast)";"Synthesis of PA";"CDP-diacylglycerol biosynthesis I";"Palmitoyl ethanolamide biosynthesis";"Glycerolipid metabolism";"Anandamide biosynthesis I";"Stigma estolide biosynthesis";"Glycerophospholipid metabolism";"Phospholipid remodeling (phosphatidate, yeast)";"CDP-diacylglycerol biosynthesis III";"Anandamide biosynthesis II";"Palmitoleate biosynthesis III (cyanobacteria)";"Plasmalogen biosynthesis"
XP_046429876.1	27	Reactome: R-HSA-159236;Reactome: R-HSA-9609690;Reactome: R-HSA-3108214;Reactome: R-HSA-168325;Reactome: R-HSA-1169408;Reactome: R-HSA-159231;Reactome: R-HSA-4570464;Reactome: R-HSA-9610379;Reactome: R-HSA-4551638;Reactome: R-HSA-165054;Reactome: R-HSA-6784531;Reactome: R-HSA-4085377;Reactome: R-HSA-170822;Reactome: R-HSA-3232142;Reactome: R-HSA-180910;Reactome: R-HSA-3371453;Reactome: R-HSA-159230;Reactome: R-HSA-5578749;Reactome: R-HSA-180746;Reactome: R-HSA-191859;Reactome: R-HSA-4615885;Reactome: R-HSA-168276;Reactome: R-HSA-3301854;Reactome: R-HSA-5619107;Reactome: R-HSA-168333;Reactome: R-HSA-159227;Reactome: R-HSA-168271	"Transport of Mature mRNA derived from an Intron-Containing Transcript";"HCMV Early Events";"SUMOylation of DNA damage response and repair proteins";"Viral Messenger RNA Synthesis";"ISG15 antiviral mechanism";"Transport of Mature mRNA Derived from an Intronless Transcript";"SUMOylation of RNA binding proteins";"HCMV Late Events";"SUMOylation of chromatin organization proteins";"Rev-mediated nuclear export of HIV RNA";"tRNA processing in the nucleus";"SUMOylation of SUMOylation proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"SUMOylation of ubiquitinylation proteins";"Vpr-mediated nuclear import of PICs";"Regulation of HSF1-mediated heat shock response";"Transport of the SLBP Dependant Mature mRNA";"Transcriptional regulation by small RNAs";"Nuclear import of Rev protein";"snRNP Assembly";"SUMOylation of DNA replication proteins";"NS1 Mediated Effects on Host Pathways";"Nuclear Pore Complex (NPC) Disassembly";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"NEP/NS2 Interacts with the Cellular Export Machinery";"Transport of the SLBP independent Mature mRNA";"Transport of Ribonucleoproteins into the Host Nucleus"
XP_046430195.1	2	Reactome: R-HSA-3928665;Reactome: R-HSA-2682334	"EPH-ephrin mediated repulsion of cells";"EPH-Ephrin signaling"
XP_046421011.1	6	KEGG: 00073+1.2.1.84;MetaCyc: PWY-7656;MetaCyc: PWY-6733;Reactome: R-HSA-9640463;MetaCyc: PWY-7782;MetaCyc: PWY-5884	"Cutin, suberine and wax biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Sporopollenin precursors biosynthesis";"Wax biosynthesis";"Plasmalogen biosynthesis";"Wax esters biosynthesis I"
XP_046432958.1	1	Reactome: R-HSA-110362	"POLB-Dependent Long Patch Base Excision Repair"
XP_046430919.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_046419717.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046426066.1	12	Reactome: R-HSA-112382;Reactome: R-HSA-167243;Reactome: R-HSA-167238;Reactome: R-HSA-75955;Reactome: R-HSA-167246;Reactome: R-HSA-167290;Reactome: R-HSA-6804756;Reactome: R-HSA-167152;Reactome: R-HSA-674695;Reactome: R-HSA-6796648;Reactome: R-HSA-167200;Reactome: R-HSA-167287	"Formation of RNA Pol II elongation complex";"Tat-mediated HIV elongation arrest and recovery";"Pausing and recovery of Tat-mediated HIV elongation";"RNA Polymerase II Transcription Elongation";"Tat-mediated elongation of the HIV-1 transcript";"Pausing and recovery of HIV elongation";"Regulation of TP53 Activity through Phosphorylation";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Polymerase II Pre-transcription Events";"TP53 Regulates Transcription of DNA Repair Genes";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"HIV elongation arrest and recovery"
XP_046435671.1	2	Reactome: R-HSA-5628897;Reactome: R-HSA-611105	"TP53 Regulates Metabolic Genes";"Respiratory electron transport"
XP_046434366.1	1	Reactome: R-HSA-8949613	"Cristae formation"
XP_046420643.1	11	Reactome: R-HSA-5358606;Reactome: R-HSA-5693568;Reactome: R-HSA-5693579;Reactome: R-HSA-5693607;Reactome: R-HSA-5685942;Reactome: R-HSA-69473;Reactome: R-HSA-6804756;Reactome: R-HSA-5685938;Reactome: R-HSA-5693554;Reactome: R-HSA-5693616;Reactome: R-HSA-5358565	"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"Resolution of D-loop Structures through Holliday Junction Intermediates";"Homologous DNA Pairing and Strand Exchange";"Processing of DNA double-strand break ends";"HDR through Homologous Recombination (HRR)";"G2/M DNA damage checkpoint";"Regulation of TP53 Activity through Phosphorylation";"HDR through Single Strand Annealing (SSA)";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Presynaptic phase of homologous DNA pairing and strand exchange";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)"
XP_046432844.1	13	Reactome: R-HSA-1799339;Reactome: R-HSA-2408557;Reactome: R-HSA-72706;Reactome: R-HSA-192823;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-72689;Reactome: R-HSA-9633012;Reactome: R-HSA-72764;Reactome: R-HSA-975956;Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-975957	"SRP-dependent cotranslational protein targeting to membrane";"Selenocysteine synthesis";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Formation of a pool of free 40S subunits";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
XP_046432689.1	2	Reactome: R-HSA-5576892;Reactome: R-HSA-445095	"Phase 0 - rapid depolarisation";"Interaction between L1 and Ankyrins"
XP_046409402.1	3	Reactome: R-HSA-74259;Reactome: R-HSA-196807;Reactome: R-HSA-73621	"Purine catabolism";"Nicotinate metabolism";"Pyrimidine catabolism"
XP_046429371.1	7	KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1	"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Thermogenesis";"Human cytomegalovirus infection";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Relaxin signaling pathway"
XP_046425772.1	1	Reactome: R-HSA-211981	"Xenobiotics"
XP_046424771.1	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
XP_046429944.1	3	Reactome: R-HSA-5083627;Reactome: R-HSA-5173105;Reactome: R-HSA-2022854	"Defective LARGE causes MDDGA6 and MDDGB6";"O-linked glycosylation";"Keratan sulfate biosynthesis"
XP_046412574.1	3	Reactome: R-HSA-373080;Reactome: R-HSA-4608870;Reactome: R-HSA-4086400	"Class B/2 (Secretin family receptors)";"Asymmetric localization of PCP proteins";"PCP/CE pathway"
XP_046428540.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_046427765.1	6	KEGG: 05235+3.1.3.16;Reactome: R-HSA-5693565;Reactome: R-HSA-5675221;KEGG: 04658+3.1.3.16;Reactome: R-HSA-8939211;KEGG: 04660+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Negative regulation of MAPK pathway";"Th1 and Th2 cell differentiation";"ESR-mediated signaling";"T cell receptor signaling pathway"
XP_046415911.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_046420977.1	1	Reactome: R-HSA-6784531	"tRNA processing in the nucleus"
XP_046411541.1	16	Reactome: R-HSA-6791226;Reactome: R-HSA-72702;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-72706;Reactome: R-HSA-2408557;Reactome: R-HSA-975957;Reactome: R-HSA-72649;Reactome: R-HSA-72764;Reactome: R-HSA-156902;Reactome: R-HSA-192823;Reactome: R-HSA-72689;Reactome: R-HSA-1799339;Reactome: R-HSA-72695	"Major pathway of rRNA processing in the nucleolus and cytosol";"Ribosomal scanning and start codon recognition";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Selenocysteine synthesis";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Translation initiation complex formation";"Eukaryotic Translation Termination";"Peptide chain elongation";"Viral mRNA Translation";"Formation of a pool of free 40S subunits";"SRP-dependent cotranslational protein targeting to membrane";"Formation of the ternary complex, and subsequently, the 43S complex"
XP_046436737.1	2	Reactome: R-HSA-380270;Reactome: R-HSA-380320	"Recruitment of mitotic centrosome proteins and complexes";"Recruitment of NuMA to mitotic centrosomes"
XP_046431699.1	1	Reactome: R-HSA-1237044	"Erythrocytes take up carbon dioxide and release oxygen"
XP_046427356.1	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
XP_046435688.1	2	KEGG: 00480+1.11.1.15;Reactome: R-HSA-3299685	"Glutathione metabolism";"Detoxification of Reactive Oxygen Species"
XP_046424918.1	3	Reactome: R-HSA-983168;MetaCyc: PWY-7511;Reactome: R-HSA-6798695	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination";"Neutrophil degranulation"
XP_046412082.1	1	Reactome: R-HSA-5663220	"RHO GTPases Activate Formins"
XP_046416649.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046423528.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046415441.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046434601.1	57	Reactome: R-HSA-174154;Reactome: R-HSA-174184;Reactome: R-HSA-8939902;Reactome: R-HSA-2467813;Reactome: R-HSA-5607761;Reactome: R-HSA-5658442;Reactome: R-HSA-983168;Reactome: R-HSA-6798695;Reactome: R-HSA-5678895;Reactome: R-HSA-180585;Reactome: R-HSA-5610785;Reactome: R-HSA-8939236;Reactome: R-HSA-174084;Reactome: R-HSA-8951664;Reactome: R-HSA-5689880;Reactome: R-HSA-349425;Reactome: R-HSA-1236978;Reactome: R-HSA-4608870;Reactome: R-HSA-4641257;Reactome: R-HSA-202424;Reactome: R-HSA-75815;Reactome: R-HSA-69017;Reactome: R-HSA-5358346;Reactome: R-HSA-69601;Reactome: R-HSA-5676590;Reactome: R-HSA-5362768;Reactome: R-HSA-9604323;Reactome: R-HSA-1169091;Reactome: R-HSA-382556;Reactome: R-HSA-68949;Reactome: R-HSA-174178;Reactome: R-HSA-2871837;Reactome: R-HSA-195253;Reactome: R-HSA-1236974;Reactome: R-HSA-5610780;Reactome: R-HSA-450408;Reactome: R-HSA-5632684;Reactome: R-HSA-4641258;Reactome: R-HSA-211733;Reactome: R-HSA-5668541;Reactome: R-HSA-9010553;Reactome: R-HSA-8941858;Reactome: R-HSA-350562;Reactome: R-HSA-5689603;Reactome: R-HSA-68827;Reactome: R-HSA-5607764;Reactome: R-HSA-180534;Reactome: R-HSA-187577;Reactome: R-HSA-1234176;Reactome: R-HSA-8948751;Reactome: R-HSA-69481;Reactome: R-HSA-8852276;Reactome: R-HSA-5610783;Reactome: R-HSA-8854050;Reactome: R-HSA-9020702;Reactome: R-HSA-174113;Reactome: R-HSA-5687128	"APC/C:Cdc20 mediated degradation of Securin";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Regulation of RUNX2 expression and activity";"Separation of Sister Chromatids";"Dectin-1 mediated noncanonical NF-kB signaling";"Regulation of RAS by GAPs";"Antigen processing: Ubiquitination & Proteasome degradation";"Neutrophil degranulation";"Defective CFTR causes cystic fibrosis";"Vif-mediated degradation of APOBEC3G";"GLI3 is processed to GLI3R by the proteasome";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Autodegradation of Cdh1 by Cdh1:APC/C";"Neddylation";"Ub-specific processing proteases";"Autodegradation of the E3 ubiquitin ligase COP1";"Cross-presentation of soluble exogenous antigens (endosomes)";"Asymmetric localization of PCP proteins";"Degradation of AXIN";"Downstream TCR signaling";"Ubiquitin-dependent degradation of Cyclin D";"CDK-mediated phosphorylation and removal of Cdc6";"Hedgehog ligand biogenesis";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"NIK-->noncanonical NF-kB signaling";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Negative regulation of NOTCH4 signaling";"Activation of NF-kappaB in B cells";"ABC-family proteins mediated transport";"Orc1 removal from chromatin";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"FCERI mediated NF-kB activation";"Degradation of beta-catenin by the destruction complex";"ER-Phagosome pathway";"Degradation of GLI1 by the proteasome";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Hedgehog 'on' state";"Degradation of DVL";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"TNFR2 non-canonical NF-kB pathway";"Regulation of expression of SLITs and ROBOs";"Regulation of RUNX3 expression and activity";"Regulation of ornithine decarboxylase (ODC)";"UCH proteinases";"CDT1 association with the CDC6:ORC:origin complex";"CLEC7A (Dectin-1) signaling";"Vpu mediated degradation of CD4";"SCF(Skp2)-mediated degradation of p27/p21";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of PTEN stability and activity";"G2/M Checkpoints";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Degradation of GLI2 by the proteasome";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Interleukin-1 signaling";"SCF-beta-TrCP mediated degradation of Emi1";"MAPK6/MAPK4 signaling"
XP_046423216.1	1	KEGG: 04660+2.7.10.2	"T cell receptor signaling pathway"
XP_046410721.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046426457.1	6	Reactome: R-HSA-68877;Reactome: R-HSA-2467813;Reactome: R-HSA-9648025;Reactome: R-HSA-141444;Reactome: R-HSA-5663220;Reactome: R-HSA-2500257	"Mitotic Prometaphase";"Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"RHO GTPases Activate Formins";"Resolution of Sister Chromatid Cohesion"
XP_046433910.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_046429767.1	6	KEGG: 00010+5.4.2.11;MetaCyc: PWY-1622;KEGG: 00260+5.4.2.11;KEGG: 00680+5.4.2.11;MetaCyc: PWY-8004;MetaCyc: PWY-5484	"Glycolysis / Gluconeogenesis";"Formaldehyde assimilation I (serine pathway)";"Glycine, serine and threonine metabolism";"Methane metabolism";"Entner-Doudoroff pathway I";"Glycolysis II (from fructose 6-phosphate)"
XP_046416734.1	5	MetaCyc: PWY-7921;KEGG: 00514+2.4.1.109;MetaCyc: PWY-7979;KEGG: 00515+2.4.1.109;MetaCyc: PWY-7922	"Protein O-mannosylation I (yeast)";"Other types of O-glycan biosynthesis";"Protein O-mannosylation III (mammals, core M3)";"Mannose type O-glycan biosynthesis";"Protein O-mannosylation II (mammals, core M1 and core M2)"
XP_046409772.1	12	Reactome: R-HSA-193648;KEGG: 04926+2.7.11.1;Reactome: R-HSA-416476;KEGG: 05163+2.7.11.1;Reactome: R-HSA-416482;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;Reactome: R-HSA-418885;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;Reactome: R-HSA-194840	"NRAGE signals death through JNK";"Relaxin signaling pathway";"G alpha (q) signalling events";"Human cytomegalovirus infection";"G alpha (12/13) signalling events";"PI3K-Akt signaling pathway";"mTOR signaling pathway";"DCC mediated attractive signaling";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Thermogenesis";"Rho GTPase cycle"
XP_046417684.1	1	KEGG: 00970+6.1.1.3	"Aminoacyl-tRNA biosynthesis"
XP_046417753.1	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
XP_046419774.1	1	Reactome: R-HSA-390522	"Striated Muscle Contraction"
XP_046423875.1	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_046429732.1	10	Reactome: R-HSA-499943;MetaCyc: PWY-3841;MetaCyc: PWY-7187;MetaCyc: PWY-7210;MetaCyc: PWY-7184;KEGG: 00240+2.1.1.45;MetaCyc: PWY-7198;MetaCyc: PWY-7199;KEGG: 00670+2.1.1.45;Reactome: R-HSA-69205	"Interconversion of nucleotide di- and triphosphates";"Folate transformations II (plants)";"Pyrimidine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Pyrimidine metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Pyrimidine deoxyribonucleosides salvage";"One carbon pool by folate";"G1/S-Specific Transcription"
XP_046425178.1	1	Reactome: R-HSA-4615885	"SUMOylation of DNA replication proteins"
XP_046415551.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046412593.1	1	Reactome: R-HSA-419771	"Opsins"
XP_046422713.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_046415813.1	2	Reactome: R-HSA-196299;Reactome: R-HSA-4641262	"Beta-catenin phosphorylation cascade";"Disassembly of the destruction complex and recruitment of AXIN to the membrane"
XP_046428220.1	2	Reactome: R-HSA-6804115;Reactome: R-HSA-429947	"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Deadenylation of mRNA"
XP_046426818.1	3	MetaCyc: PWY-6700;MetaCyc: PWY-8106;Reactome: R-HSA-6782315	"Queuosine biosynthesis I (de novo)";"Queuosine biosynthesis III (queuosine salvage)";"tRNA modification in the nucleus and cytosol"
XP_046417197.1	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
XP_046420211.1	6	KEGG: 00073+1.2.1.84;MetaCyc: PWY-7656;MetaCyc: PWY-6733;Reactome: R-HSA-9640463;MetaCyc: PWY-5884;MetaCyc: PWY-7782	"Cutin, suberine and wax biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Sporopollenin precursors biosynthesis";"Wax biosynthesis";"Wax esters biosynthesis I";"Plasmalogen biosynthesis"
XP_046418152.1	1	Reactome: R-HSA-1445148	"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
XP_046425412.1	2	Reactome: R-HSA-917729;Reactome: R-HSA-162588	"Endosomal Sorting Complex Required For Transport (ESCRT)";"Budding and maturation of HIV virion"
XP_046428738.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046422101.1	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
XP_046411236.1	1	Reactome: R-HSA-8949613	"Cristae formation"
XP_046423404.1	11	Reactome: R-HSA-3214847;Reactome: R-HSA-6804756;Reactome: R-HSA-167161;Reactome: R-HSA-73779;Reactome: R-HSA-73776;Reactome: R-HSA-674695;Reactome: R-HSA-5689880;Reactome: R-HSA-167162;Reactome: R-HSA-167172;Reactome: R-HSA-75953;Reactome: R-HSA-76042	"HATs acetylate histones";"Regulation of TP53 Activity through Phosphorylation";"HIV Transcription Initiation";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Pre-transcription Events";"Ub-specific processing proteases";"RNA Polymerase II HIV Promoter Escape";"Transcription of the HIV genome";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Transcription Initiation And Promoter Clearance"
XP_046410722.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046427064.1	3	Reactome: R-HSA-140837;Reactome: R-HSA-9645722;Reactome: R-HSA-111471	"Intrinsic Pathway of Fibrin Clot Formation";"Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function";"Apoptotic factor-mediated response"
XP_046436732.1	1	Reactome: R-HSA-8949613	"Cristae formation"
XP_046419841.1	3	KEGG: 00730+3.1.3.2;KEGG: 00740+3.1.3.2;MetaCyc: PWY-6348	"Thiamine metabolism";"Riboflavin metabolism";"Phosphate acquisition"
XP_046418810.1	3	Reactome: R-HSA-5250924;Reactome: R-HSA-72163;Reactome: R-HSA-72165	"B-WICH complex positively regulates rRNA expression";"mRNA Splicing - Major Pathway";"mRNA Splicing - Minor Pathway"
XP_046432735.1	7	Reactome: R-HSA-380259;Reactome: R-HSA-8854518;Reactome: R-HSA-2565942;Reactome: R-HSA-380270;Reactome: R-HSA-380320;Reactome: R-HSA-5620912;Reactome: R-HSA-380284	"Loss of Nlp from mitotic centrosomes";"AURKA Activation by TPX2";"Regulation of PLK1 Activity at G2/M Transition";"Recruitment of mitotic centrosome proteins and complexes";"Recruitment of NuMA to mitotic centrosomes";"Anchoring of the basal body to the plasma membrane";"Loss of proteins required for interphase microtubule organization from the centrosome"
XP_046412315.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_046430930.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_046427509.1	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
XP_046416220.1	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
XP_046409413.1	2	Reactome: R-HSA-375276;Reactome: R-HSA-416476	"Peptide ligand-binding receptors";"G alpha (q) signalling events"
XP_046432760.1	2	Reactome: R-HSA-194840;Reactome: R-HSA-8876198	"Rho GTPase cycle";"RAB GEFs exchange GTP for GDP on RABs"
XP_046412445.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_046431931.1	12	Reactome: R-HSA-2408550;KEGG: 00920+2.7.1.25;KEGG: 00450+2.7.7.4;KEGG: 00230+2.7.1.25;MetaCyc: PWY-5278;KEGG: 00261+2.7.7.4;KEGG: 00230+2.7.7.4;MetaCyc: PWY-5340;MetaCyc: PWY-6683;Reactome: R-HSA-174362;KEGG: 00920+2.7.7.4;MetaCyc: PWY-6932	"Metabolism of ingested H2SeO4 and H2SeO3 into H2Se";"Sulfur metabolism";"Selenocompound metabolism";"Purine metabolism";"Sulfite oxidation III";"Monobactam biosynthesis";"Purine metabolism";"Sulfate activation for sulfonation";"Assimilatory sulfate reduction III";"Transport and synthesis of PAPS";"Sulfur metabolism";"Selenate reduction"
XP_046435847.1	3	KEGG: 00240+1.3.5.2;Reactome: R-HSA-500753;MetaCyc: PWY-5686	"Pyrimidine metabolism";"Pyrimidine biosynthesis";"UMP biosynthesis I"
XP_046425975.1	1	Reactome: R-HSA-3214842	"HDMs demethylate histones"
XP_046429787.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046431915.1	1	Reactome: R-HSA-430039	"mRNA decay by 5' to 3' exoribonuclease"
XP_046423727.1	2	Reactome: R-HSA-71336;KEGG: 00710+2.7.1.14	"Pentose phosphate pathway";"Carbon fixation in photosynthetic organisms"
XP_046426256.1	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
XP_046430613.1	39	Reactome: R-HSA-5655253;Reactome: R-HSA-190371;Reactome: R-HSA-8853338;Reactome: R-HSA-5654704;Reactome: R-HSA-5654720;Reactome: R-HSA-109704;Reactome: R-HSA-1839122;Reactome: R-HSA-2219530;Reactome: R-HSA-2033519;Reactome: R-HSA-5654719;Reactome: R-HSA-5654699;Reactome: R-HSA-5654700;Reactome: R-HSA-5654693;Reactome: R-HSA-1839130;Reactome: R-HSA-2033514;Reactome: R-HSA-190373;Reactome: R-HSA-5654221;Reactome: R-HSA-5654732;Reactome: R-HSA-5655302;Reactome: R-HSA-190372;Reactome: R-HSA-5658623;Reactome: R-HSA-5654712;Reactome: R-HSA-1257604;Reactome: R-HSA-5654695;Reactome: R-HSA-6811558;Reactome: R-HSA-5654727;Reactome: R-HSA-5654687;Reactome: R-HSA-5654706;Reactome: R-HSA-5654688;Reactome: R-HSA-5654689;Reactome: R-HSA-5654733;Reactome: R-HSA-5654710;Reactome: R-HSA-5673001;Reactome: R-HSA-5654219;Reactome: R-HSA-190375;Reactome: R-HSA-5654227;Reactome: R-HSA-5654228;Reactome: R-HSA-5654726;Reactome: R-HSA-190322	"Signaling by FGFR2 in disease";"FGFR3b ligand binding and activation";"Signaling by FGFR3 point mutants in cancer";"SHC-mediated cascade:FGFR3";"PI-3K cascade:FGFR4";"PI3K Cascade";"Signaling by activated point mutants of FGFR1";"Constitutive Signaling by Aberrant PI3K in Cancer";"Activated point mutants of FGFR2";"SHC-mediated cascade:FGFR4";"SHC-mediated cascade:FGFR2";"FRS-mediated FGFR2 signaling";"FRS-mediated FGFR1 signaling";"Signaling by activated point mutants of FGFR3";"FGFR3 mutant receptor activation";"FGFR1c ligand binding and activation";"Phospholipase C-mediated cascade, FGFR2";"Negative regulation of FGFR3 signaling";"Signaling by FGFR1 in disease";"FGFR3c ligand binding and activation";"FGFRL1 modulation of FGFR1 signaling";"FRS-mediated FGFR4 signaling";"PIP3 activates AKT signaling";"PI-3K cascade:FGFR2";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"Negative regulation of FGFR2 signaling";"Downstream signaling of activated FGFR1";"FRS-mediated FGFR3 signaling";"SHC-mediated cascade:FGFR1";"PI-3K cascade:FGFR1";"Negative regulation of FGFR4 signaling";"PI-3K cascade:FGFR3";"RAF/MAP kinase cascade";"Phospholipase C-mediated cascade: FGFR1";"FGFR2c ligand binding and activation";"Phospholipase C-mediated cascade, FGFR3";"Phospholipase C-mediated cascade, FGFR4";"Negative regulation of FGFR1 signaling";"FGFR4 ligand binding and activation"
XP_046425754.1	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
XP_046435223.1	2	Reactome: R-HSA-6783310;Reactome: R-HSA-5693568	"Fanconi Anemia Pathway";"Resolution of D-loop Structures through Holliday Junction Intermediates"
XP_046436686.1	12	Reactome: R-HSA-6807878;Reactome: R-HSA-3371497;Reactome: R-HSA-2500257;Reactome: R-HSA-5663220;Reactome: R-HSA-2467813;Reactome: R-HSA-6811436;Reactome: R-HSA-9646399;Reactome: R-HSA-9609690;Reactome: R-HSA-68877;Reactome: R-HSA-141444;Reactome: R-HSA-9648025;Reactome: R-HSA-2132295	"COPI-mediated anterograde transport";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Resolution of Sister Chromatid Cohesion";"RHO GTPases Activate Formins";"Separation of Sister Chromatids";"COPI-independent Golgi-to-ER retrograde traffic";"Aggrephagy";"HCMV Early Events";"Mitotic Prometaphase";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"EML4 and NUDC in mitotic spindle formation";"MHC class II antigen presentation"
XP_046424496.1	3	Reactome: R-HSA-6807878;Reactome: R-HSA-6811440;Reactome: R-HSA-6811438	"COPI-mediated anterograde transport";"Retrograde transport at the Trans-Golgi-Network";"Intra-Golgi traffic"
XP_046432847.1	3	Reactome: R-HSA-3108214;Reactome: R-HSA-5696394;Reactome: R-HSA-5696395	"SUMOylation of DNA damage response and repair proteins";"DNA Damage Recognition in GG-NER";"Formation of Incision Complex in GG-NER"
XP_046430206.1	2	Reactome: R-HSA-3928665;Reactome: R-HSA-2682334	"EPH-ephrin mediated repulsion of cells";"EPH-Ephrin signaling"
XP_046415013.1	7	KEGG: 00220+3.5.1.2;KEGG: 00471+3.5.1.2;Reactome: R-HSA-8964539;Reactome: R-HSA-5628897;MetaCyc: PWY-5921;KEGG: 00250+3.5.1.2;Reactome: R-HSA-210500	"Arginine biosynthesis";"D-Glutamine and D-glutamate metabolism";"Glutamate and glutamine metabolism";"TP53 Regulates Metabolic Genes";"Glutaminyl-trnagln biosynthesis via transamidation";"Alanine, aspartate and glutamate metabolism";"Glutamate Neurotransmitter Release Cycle"
XP_046426005.1	2	Reactome: R-HSA-8866654;MetaCyc: PWY-7511	"E3 ubiquitin ligases ubiquitinate target proteins";"Protein ubiquitination"
XP_046434718.1	4	Reactome: R-HSA-3304356;Reactome: R-HSA-2173788;Reactome: R-HSA-3656532;Reactome: R-HSA-2173789	"SMAD2/3 Phosphorylation Motif Mutants in Cancer";"Downregulation of TGF-beta receptor signaling";"TGFBR1 KD Mutants in Cancer";"TGF-beta receptor signaling activates SMADs"
XP_046420904.1	2	Reactome: R-HSA-8936459;Reactome: R-HSA-3214841	"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"PKMTs methylate histone lysines"
XP_046418327.1	7	Reactome: R-HSA-1362300;Reactome: R-HSA-156711;Reactome: R-HSA-1538133;Reactome: R-HSA-69202;Reactome: R-HSA-69656;Reactome: R-HSA-69205;Reactome: R-HSA-1362277	"Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1";"Polo-like kinase mediated events";"G0 and Early G1";"Cyclin E associated events during G1/S transition";"Cyclin A:Cdk2-associated events at S phase entry";"G1/S-Specific Transcription";"Transcription of E2F targets under negative control by DREAM complex"
XP_046418402.1	1	Reactome: R-HSA-204005	"COPII-mediated vesicle transport"
XP_046420799.1	10	Reactome: R-HSA-2151209;Reactome: R-HSA-9619483;Reactome: R-HSA-380972;Reactome: R-HSA-1445148;Reactome: R-HSA-1632852;Reactome: R-HSA-9613354;Reactome: R-HSA-5628897;Reactome: R-HSA-163680;Reactome: R-HSA-200425;Reactome: R-HSA-6804756	"Activation of PPARGC1A (PGC-1alpha) by phosphorylation";"Activation of AMPK downstream of NMDARs";"Energy dependent regulation of mTOR by LKB1-AMPK";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Macroautophagy";"Lipophagy";"TP53 Regulates Metabolic Genes";"AMPK inhibits chREBP transcriptional activation activity";"Carnitine metabolism";"Regulation of TP53 Activity through Phosphorylation"
XP_046432498.1	1	Reactome: R-HSA-8876725	"Protein methylation"
XP_046435389.1	1	KEGG: 00970+6.1.1.19	"Aminoacyl-tRNA biosynthesis"
XP_046427990.1	3	Reactome: R-HSA-194840;Reactome: R-HSA-416482;Reactome: R-HSA-193648	"Rho GTPase cycle";"G alpha (12/13) signalling events";"NRAGE signals death through JNK"
XP_046414595.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046416990.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046436257.1	1	KEGG: 00480+3.4.11.1	"Glutathione metabolism"
XP_046418382.1	6	Reactome: R-HSA-5654712;Reactome: R-HSA-9028731;Reactome: R-HSA-5654700;Reactome: R-HSA-5654706;Reactome: R-HSA-5654693;Reactome: R-HSA-5673001	"FRS-mediated FGFR4 signaling";"Activated NTRK2 signals through FRS2 and FRS3";"FRS-mediated FGFR2 signaling";"FRS-mediated FGFR3 signaling";"FRS-mediated FGFR1 signaling";"RAF/MAP kinase cascade"
XP_046413280.1	16	Reactome: R-HSA-8936459;Reactome: R-HSA-9018519;Reactome: R-HSA-2559585;Reactome: R-HSA-8948700;Reactome: R-HSA-5628897;Reactome: R-HSA-8943723;Reactome: R-HSA-1912408;Reactome: R-HSA-8986944;Reactome: R-HSA-8934593;Reactome: R-HSA-4086398;Reactome: R-HSA-8853884;Reactome: R-HSA-5687128;Reactome: R-HSA-9022692;Reactome: R-HSA-426496;Reactome: R-HSA-9029569;Reactome: R-HSA-2559580	"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Estrogen-dependent gene expression";"Oncogene Induced Senescence";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"TP53 Regulates Metabolic Genes";"Regulation of PTEN mRNA translation";"Pre-NOTCH Transcription and Translation";"Transcriptional Regulation by MECP2";"Regulation of RUNX1 Expression and Activity";"Ca2+ pathway";"Transcriptional Regulation by VENTX";"MAPK6/MAPK4 signaling";"Regulation of MECP2 expression and activity";"Post-transcriptional silencing by small RNAs";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Oxidative Stress Induced Senescence"
XP_046428760.1	13	Reactome: R-HSA-6791226;Reactome: R-HSA-975957;Reactome: R-HSA-72764;Reactome: R-HSA-975956;Reactome: R-HSA-156902;Reactome: R-HSA-192823;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-72689;Reactome: R-HSA-9633012;Reactome: R-HSA-1799339;Reactome: R-HSA-2408557;Reactome: R-HSA-72706	"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Peptide chain elongation";"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Formation of a pool of free 40S subunits";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"SRP-dependent cotranslational protein targeting to membrane";"Selenocysteine synthesis";"GTP hydrolysis and joining of the 60S ribosomal subunit"
XP_046424926.1	1	Reactome: R-HSA-432720	"Lysosome Vesicle Biogenesis"
XP_046417171.1	1	Reactome: R-HSA-5576886	"Phase 4 - resting membrane potential"
XP_046415293.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046423272.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046417175.1	2	Reactome: R-HSA-390471;Reactome: R-HSA-1660662	"Association of TriC/CCT with target proteins during biosynthesis";"Glycosphingolipid metabolism"
XP_046433162.1	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286	"Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation"
XP_046416938.1	9	Reactome: R-HSA-5685938;Reactome: R-HSA-5693616;Reactome: R-HSA-5693554;Reactome: R-HSA-6804756;Reactome: R-HSA-69473;Reactome: R-HSA-5693579;Reactome: R-HSA-5685942;Reactome: R-HSA-5693607;Reactome: R-HSA-5693568	"HDR through Single Strand Annealing (SSA)";"Presynaptic phase of homologous DNA pairing and strand exchange";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Regulation of TP53 Activity through Phosphorylation";"G2/M DNA damage checkpoint";"Homologous DNA Pairing and Strand Exchange";"HDR through Homologous Recombination (HRR)";"Processing of DNA double-strand break ends";"Resolution of D-loop Structures through Holliday Junction Intermediates"
XP_046421880.1	3	Reactome: R-HSA-8939902;Reactome: R-HSA-6785807;Reactome: R-HSA-8878166	"Regulation of RUNX2 expression and activity";"Interleukin-4 and Interleukin-13 signaling";"Transcriptional regulation by RUNX2"
XP_046412595.1	1	Reactome: R-HSA-419771	"Opsins"
XP_046422105.1	1	Reactome: R-HSA-8949613	"Cristae formation"
XP_046433011.1	7	Reactome: R-HSA-69656;Reactome: R-HSA-69202;Reactome: R-HSA-1538133;Reactome: R-HSA-1362277;Reactome: R-HSA-69205;Reactome: R-HSA-156711;Reactome: R-HSA-1362300	"Cyclin A:Cdk2-associated events at S phase entry";"Cyclin E associated events during G1/S transition";"G0 and Early G1";"Transcription of E2F targets under negative control by DREAM complex";"G1/S-Specific Transcription";"Polo-like kinase mediated events";"Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1"
XP_046426425.1	9	Reactome: R-HSA-5678895;Reactome: R-HSA-8856828;Reactome: R-HSA-382556;Reactome: R-HSA-5627083;Reactome: R-HSA-9646399;Reactome: R-HSA-5689880;Reactome: R-HSA-9615710;Reactome: R-HSA-8856825;Reactome: R-HSA-9613829	"Defective CFTR causes cystic fibrosis";"Clathrin-mediated endocytosis";"ABC-family proteins mediated transport";"RHO GTPases regulate CFTR trafficking";"Aggrephagy";"Ub-specific processing proteases";"Late endosomal microautophagy";"Cargo recognition for clathrin-mediated endocytosis";"Chaperone Mediated Autophagy"
XP_046434677.1	1	Reactome: R-HSA-5358493	"Synthesis of diphthamide-EEF2"
XP_046427792.1	10	MetaCyc: PWY-7559;KEGG: 00480+2.3.2.2+3.4.19.13;MetaCyc: PWY-5826;MetaCyc: PWY-6842;MetaCyc: PWY-4061;MetaCyc: PWY-7112;MetaCyc: PWY-4041;KEGG: 00460+2.3.2.2;MetaCyc: PWY-8001;KEGG: 00430+2.3.2.2	"Glutathione degradation (DUG pathway";"Glutathione metabolism";"Hypoglycin biosynthesis";"Glutathione-mediated detoxification II";"Glutathione-mediated detoxification I";"4-hydroxy-2-nonenal detoxification";"Gamma-glutamyl cycle";"Cyanoamino acid metabolism";"Felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis";"Taurine and hypotaurine metabolism"
XP_046421271.1	1	Reactome: R-HSA-425561	"Sodium/Calcium exchangers"
XP_046416744.1	2	Reactome: R-HSA-3214841;Reactome: R-HSA-8936459	"PKMTs methylate histone lysines";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"
XP_046416793.1	5	KEGG: 00534+2.4.1.224+2.4.1.225;Reactome: R-HSA-3656253;Reactome: R-HSA-2022928;Reactome: R-HSA-3656237;MetaCyc: PWY-6558	"Glycosaminoglycan biosynthesis - heparan sulfate / heparin";"Defective EXT1 causes exostoses 1, TRPS2 and CHDS";"HS-GAG biosynthesis";"Defective EXT2 causes exostoses 2";"Heparan sulfate biosynthesis (late stages)"
XP_046430952.1	8	KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05163+2.7.11.1;Reactome: R-HSA-428540;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1	"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Human cytomegalovirus infection";"Activation of RAC1";"Relaxin signaling pathway";"Thermogenesis";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection"
XP_046409691.1	1	Reactome: R-HSA-163125	"Post-translational modification: synthesis of GPI-anchored proteins"
XP_046421107.1	4	KEGG: 00785+2.3.1.181;MetaCyc: PWY-6987;Reactome: R-HSA-389661;MetaCyc: PWY-7382	"Lipoic acid metabolism";"Lipoate biosynthesis and incorporation III (Bacillus)";"Glyoxylate metabolism and glycine degradation";"Lipoate biosynthesis and incorporation IV (yeast)"
XP_046416783.1	1	Reactome: R-HSA-2151201	"Transcriptional activation of mitochondrial biogenesis"
XP_046425934.1	3	Reactome: R-HSA-8876198;Reactome: R-HSA-6811440;Reactome: R-HSA-6811438	"RAB GEFs exchange GTP for GDP on RABs";"Retrograde transport at the Trans-Golgi-Network";"Intra-Golgi traffic"
XP_046435950.1	9	Reactome: R-HSA-5696394;Reactome: R-HSA-6782210;Reactome: R-HSA-110314;Reactome: R-HSA-6781823;Reactome: R-HSA-8951664;Reactome: R-HSA-5696395;Reactome: R-HSA-6781827;Reactome: R-HSA-5696400;Reactome: R-HSA-6782135	"DNA Damage Recognition in GG-NER";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Recognition of DNA damage by PCNA-containing replication complex";"Formation of TC-NER Pre-Incision Complex";"Neddylation";"Formation of Incision Complex in GG-NER";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Dual Incision in GG-NER";"Dual incision in TC-NER"
XP_046419592.1	3	MetaCyc: PWY-6317;KEGG: 00010+5.1.3.3;KEGG: 00052+5.1.3.3	"D-galactose degradation I (Leloir pathway)";"Glycolysis / Gluconeogenesis";"Galactose metabolism"
XP_046423608.1	1	Reactome: R-HSA-2022377	"Metabolism of Angiotensinogen to Angiotensins"
XP_046413469.1	9	Reactome: R-HSA-400206;Reactome: R-HSA-400253;Reactome: R-HSA-1368082;Reactome: R-HSA-1989781;Reactome: R-HSA-2426168;Reactome: R-HSA-2151201;Reactome: R-HSA-1368108;Reactome: R-HSA-381340;Reactome: R-HSA-5617472	"Regulation of lipid metabolism by PPARalpha";"Circadian Clock";"RORA activates gene expression";"PPARA activates gene expression";"Activation of gene expression by SREBF (SREBP)";"Transcriptional activation of mitochondrial biogenesis";"BMAL1:CLOCK,NPAS2 activates circadian gene expression";"Transcriptional regulation of white adipocyte differentiation";"Activation of anterior HOX genes in hindbrain development during early embryogenesis"
XP_046414295.1	6	Reactome: R-HSA-68877;Reactome: R-HSA-2467813;Reactome: R-HSA-9648025;Reactome: R-HSA-141444;Reactome: R-HSA-5663220;Reactome: R-HSA-2500257	"Mitotic Prometaphase";"Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"RHO GTPases Activate Formins";"Resolution of Sister Chromatid Cohesion"
XP_046427577.1	1	Reactome: R-HSA-5620922	"BBSome-mediated cargo-targeting to cilium"
XP_046422078.1	3	Reactome: R-HSA-416482;Reactome: R-HSA-194840;Reactome: R-HSA-193648	"G alpha (12/13) signalling events";"Rho GTPase cycle";"NRAGE signals death through JNK"
XP_046419565.1	7	Reactome: R-HSA-2894862;Reactome: R-HSA-2122948;Reactome: R-HSA-9013507;Reactome: R-HSA-2644606;Reactome: R-HSA-2979096;MetaCyc: PWY-7511;Reactome: R-HSA-2691232	"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Activated NOTCH1 Transmits Signal to the Nucleus";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Protein ubiquitination";"Constitutive Signaling by NOTCH1 HD Domain Mutants"
XP_046420052.1	1	Reactome: R-HSA-3214842	"HDMs demethylate histones"
XP_046429269.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046416966.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046429387.1	9	Reactome: R-HSA-110328;Reactome: R-HSA-110329;Reactome: R-HSA-9656255;Reactome: R-HSA-5649702;Reactome: R-HSA-9657050;Reactome: R-HSA-110357;Reactome: R-HSA-110330;Reactome: R-HSA-110331;Reactome: R-HSA-9656256	"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"Cleavage of the damaged pyrimidine";"Defective OGG1 Substrate Binding";"APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway";"Defective OGG1 Localization";"Displacement of DNA glycosylase by APEX1";"Recognition and association of DNA glycosylase with site containing an affected purine";"Cleavage of the damaged purine";"Defective OGG1 Substrate Processing"
XP_046425414.1	2	Reactome: R-HSA-8856828;Reactome: R-HSA-8856825	"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis"
XP_046416914.1	14	KEGG: 00564+3.1.1.4+3.1.1.5;MetaCyc: PWY-8051;Reactome: R-HSA-1482788;MetaCyc: PWY-6803;KEGG: 00565+3.1.1.4;Reactome: R-HSA-975634;KEGG: 00590+3.1.1.4;MetaCyc: PWY-7783;KEGG: 00592+3.1.1.4;MetaCyc: PWY-7409;MetaCyc: PWY-7416;MetaCyc: PWY-8053;KEGG: 00591+3.1.1.4;MetaCyc: PWY-7417	"Glycerophospholipid metabolism";"Anandamide biosynthesis I";"Acyl chain remodelling of PC";"Phosphatidylcholine acyl editing";"Ether lipid metabolism";"Retinoid metabolism and transport";"Arachidonic acid metabolism";"Plasmalogen degradation";"alpha-Linolenic acid metabolism";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Anandamide biosynthesis II";"Linoleic acid metabolism";"Phospholipid remodeling (phosphatidate, yeast)"
XP_046415459.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_046426665.1	1	Reactome: R-HSA-196783	"Coenzyme A biosynthesis"
XP_046423273.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046413043.1	3	Reactome: R-HSA-3000157;Reactome: R-HSA-8874081;Reactome: R-HSA-3000171	"Laminin interactions";"MET activates PTK2 signaling";"Non-integrin membrane-ECM interactions"
XP_046427417.1	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
XP_046416449.1	2	MetaCyc: PWY-5381;KEGG: 00760+2.7.1.173+2.7.1.22	"Pyridine nucleotide cycling (plants)";"Nicotinate and nicotinamide metabolism"
XP_046435556.1	1	Reactome: R-HSA-1799339	"SRP-dependent cotranslational protein targeting to membrane"
XP_046410276.1	2	Reactome: R-HSA-6804115;Reactome: R-HSA-429947	"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Deadenylation of mRNA"
XP_046412330.1	4	MetaCyc: PWY-6483;KEGG: 00600+3.5.1.23;Reactome: R-HSA-1660662;MetaCyc: PWY-7119	"Ceramide degradation (generic)";"Sphingolipid metabolism";"Glycosphingolipid metabolism";"Ceramide and sphingolipid recycling and degradation (yeast)"
XP_046433930.1	2	KEGG: 00230+3.5.3.4;MetaCyc: PWY-5697	"Purine metabolism";"Allantoin degradation to ureidoglycolate I (urea producing)"
XP_046420266.1	15	Reactome: R-HSA-5358747;Reactome: R-HSA-4641262;Reactome: R-HSA-111465;Reactome: R-HSA-5339716;Reactome: R-HSA-5467340;Reactome: R-HSA-3769402;Reactome: R-HSA-5467333;Reactome: R-HSA-5358751;Reactome: R-HSA-5358752;Reactome: R-HSA-195253;Reactome: R-HSA-5467337;Reactome: R-HSA-5467348;Reactome: R-HSA-5689896;Reactome: R-HSA-5358749;Reactome: R-HSA-196299	"S33 mutants of beta-catenin aren't phosphorylated";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"Apoptotic cleavage of cellular proteins";"Misspliced GSK3beta mutants stabilize beta-catenin";"AXIN missense mutants destabilize the destruction complex";"Deactivation of the beta-catenin transactivating complex";"APC truncation mutants are not K63 polyubiquitinated";"S45 mutants of beta-catenin aren't phosphorylated";"T41 mutants of beta-catenin aren't phosphorylated";"Degradation of beta-catenin by the destruction complex";"APC truncation mutants have impaired AXIN binding";"Truncations of AMER1 destabilize the destruction complex";"Ovarian tumor domain proteases";"S37 mutants of beta-catenin aren't phosphorylated";"Beta-catenin phosphorylation cascade"
XP_046428012.1	1	Reactome: R-HSA-159236	"Transport of Mature mRNA derived from an Intron-Containing Transcript"
XP_046410686.1	6	Reactome: R-HSA-72702;Reactome: R-HSA-72695;Reactome: R-HSA-72706;Reactome: R-HSA-72649;Reactome: R-HSA-72689;Reactome: R-HSA-156827	"Ribosomal scanning and start codon recognition";"Formation of the ternary complex, and subsequently, the 43S complex";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Translation initiation complex formation";"Formation of a pool of free 40S subunits";"L13a-mediated translational silencing of Ceruloplasmin expression"
XP_046431696.1	1	Reactome: R-HSA-1237044	"Erythrocytes take up carbon dioxide and release oxygen"
XP_046415565.1	2	Reactome: R-HSA-4090294;Reactome: R-HSA-383280	"SUMOylation of intracellular receptors";"Nuclear Receptor transcription pathway"
XP_046428085.1	4	Reactome: R-HSA-5578775;Reactome: R-HSA-1912420;Reactome: R-HSA-936837;Reactome: R-HSA-418359	"Ion homeostasis";"Pre-NOTCH Processing in Golgi";"Ion transport by P-type ATPases";"Reduction of cytosolic Ca++ levels"
XP_046421929.1	3	Reactome: R-HSA-6787639;Reactome: R-HSA-5619078;Reactome: R-HSA-727802	"GDP-fucose biosynthesis";"Defective SLC35C1 causes congenital disorder of glycosylation 2C (CDG2C)";"Transport of nucleotide sugars"
XP_046428707.1	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_046410744.1	4	Reactome: R-HSA-112308;Reactome: R-HSA-5576893;Reactome: R-HSA-5576892;Reactome: R-HSA-419037	"Presynaptic depolarization and calcium channel opening";"Phase 2 - plateau phase";"Phase 0 - rapid depolarisation";"NCAM1 interactions"
XP_046427308.1	24	Reactome: R-HSA-456926;Reactome: R-HSA-392451;Reactome: R-HSA-418594;Reactome: R-HSA-202040;Reactome: R-HSA-6814122;Reactome: R-HSA-4086398;Reactome: R-HSA-163359;Reactome: R-HSA-9009391;Reactome: R-HSA-8964616;Reactome: R-HSA-392170;Reactome: R-HSA-418217;Reactome: R-HSA-428930;Reactome: R-HSA-420092;Reactome: R-HSA-381676;Reactome: R-HSA-8964315;Reactome: R-HSA-432040;Reactome: R-HSA-418597;Reactome: R-HSA-416476;Reactome: R-HSA-418555;Reactome: R-HSA-392851;Reactome: R-HSA-400042;Reactome: R-HSA-500657;Reactome: R-HSA-418592;Reactome: R-HSA-416482	"Thrombin signalling through proteinase activated receptors (PARs)";"G beta:gamma signalling through PI3Kgamma";"G alpha (i) signalling events";"G-protein activation";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"Ca2+ pathway";"Glucagon signaling in metabolic regulation";"Extra-nuclear estrogen signaling";"G beta:gamma signalling through CDC42";"ADP signalling through P2Y purinoceptor 12";"G beta:gamma signalling through PLC beta";"Thromboxane signalling through TP receptor";"Glucagon-type ligand receptors";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"G beta:gamma signalling through BTK";"Vasopressin regulates renal water homeostasis via Aquaporins";"G alpha (z) signalling events";"G alpha (q) signalling events";"G alpha (s) signalling events";"Prostacyclin signalling through prostacyclin receptor";"Adrenaline,noradrenaline inhibits insulin secretion";"Presynaptic function of Kainate receptors";"ADP signalling through P2Y purinoceptor 1";"G alpha (12/13) signalling events"
XP_046429121.1	2	Reactome: R-HSA-6807505;Reactome: R-HSA-72163	"RNA polymerase II transcribes snRNA genes";"mRNA Splicing - Major Pathway"
XP_046430160.1	12	KEGG: 00130+2.5.1.39;MetaCyc: PWY-5856;MetaCyc: PWY-5870;MetaCyc: PWY-5857;MetaCyc: PWY-5855;MetaCyc: PWY-6708;MetaCyc: PWY-6978;MetaCyc: PWY-5871;MetaCyc: PWY-5873;Reactome: R-HSA-2142789;MetaCyc: PWY-5872;Reactome: R-HSA-1268020	"Ubiquinone and other terpenoid-quinone biosynthesis";"Ubiquinol-9 biosynthesis (prokaryotic)";"Ubiquinol-8 biosynthesis (eukaryotic)";"Ubiquinol-10 biosynthesis (prokaryotic)";"Ubiquinol-7 biosynthesis (prokaryotic)";"Ubiquinol-8 biosynthesis (prokaryotic)";"Plastoquinol-9 biosynthesis II";"Ubiquinol-9 biosynthesis (eukaryotic)";"Ubiquinol-7 biosynthesis (eukaryotic)";"Ubiquinol biosynthesis";"Ubiquinol-10 biosynthesis (eukaryotic)";"Mitochondrial protein import"
XP_046412360.1	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
XP_046409800.1	11	Reactome: R-HSA-428890;Reactome: R-HSA-5663213;Reactome: R-HSA-8939236;Reactome: R-HSA-2029482;Reactome: R-HSA-5685938;Reactome: R-HSA-525793;Reactome: R-HSA-5693565;KEGG: 04660+2.7.10.2;Reactome: R-HSA-69231;Reactome: R-HSA-983231;Reactome: R-HSA-8940973	"Role of ABL in ROBO-SLIT signaling";"RHO GTPases Activate WASPs and WAVEs";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Regulation of actin dynamics for phagocytic cup formation";"HDR through Single Strand Annealing (SSA)";"Myogenesis";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"T cell receptor signaling pathway";"Cyclin D associated events in G1";"Factors involved in megakaryocyte development and platelet production";"RUNX2 regulates osteoblast differentiation"
XP_046410922.1	14	MetaCyc: PWY-6433;MetaCyc: PWY-7724;Reactome: R-HSA-75876;MetaCyc: PWY-5972;MetaCyc: PWY-7619;MetaCyc: PWY-7725;MetaCyc: PWY-5080;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7601;MetaCyc: PWY-8041;MetaCyc: PWY-7036;MetaCyc: PWY-6598;MetaCyc: PWY-7602;MetaCyc: PWY-7035	"Hydroxylated fatty acid biosynthesis (plants)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Synthesis of very long-chain fatty acyl-CoAs";"Stearate biosynthesis I (animals)";"Juniperonate biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Very long chain fatty acid biosynthesis I";"Fatty acid elongation";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Ultra-long-chain fatty acid biosynthesis";"Very long chain fatty acid biosynthesis II";"Sciadonate biosynthesis";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"(9Z)-tricosene biosynthesis"
XP_046430136.1	6	Reactome: R-HSA-450604;Reactome: R-HSA-450513;Reactome: R-HSA-380994;Reactome: R-HSA-429958;Reactome: R-HSA-6791226;Reactome: R-HSA-450385	"KSRP (KHSRP) binds and destabilizes mRNA";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"ATF4 activates genes in response to endoplasmic reticulum stress";"mRNA decay by 3' to 5' exoribonuclease";"Major pathway of rRNA processing in the nucleolus and cytosol";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA"
XP_046420822.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046436053.1	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
XP_046435863.1	2	Reactome: R-HSA-429947;Reactome: R-HSA-6804115	"Deadenylation of mRNA";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"
XP_046416451.1	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
XP_046419739.1	5	KEGG: 00670+1.5.1.20;MetaCyc: PWY-2201;MetaCyc: PWY-3841;Reactome: R-HSA-196757;KEGG: 00720+1.5.1.20	"One carbon pool by folate";"Folate transformations I";"Folate transformations II (plants)";"Metabolism of folate and pterines";"Carbon fixation pathways in prokaryotes"
XP_046415996.1	4	KEGG: 00270+5.3.1.23;MetaCyc: PWY-7174;Reactome: R-HSA-1237112;MetaCyc: PWY-4361	"Cysteine and methionine metabolism";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation II";"Methionine salvage pathway";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I"
XP_046410497.1	2	Reactome: R-HSA-72702;Reactome: R-HSA-72706	"Ribosomal scanning and start codon recognition";"GTP hydrolysis and joining of the 60S ribosomal subunit"
XP_046410720.1	2	Reactome: R-HSA-977443;Reactome: R-HSA-1236394	"GABA receptor activation";"Signaling by ERBB4"
XP_046427989.1	3	Reactome: R-HSA-193648;Reactome: R-HSA-194840;Reactome: R-HSA-416482	"NRAGE signals death through JNK";"Rho GTPase cycle";"G alpha (12/13) signalling events"
XP_046435665.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
XP_046409642.1	5	Reactome: R-HSA-432722;Reactome: R-HSA-8856828;Reactome: R-HSA-6811440;Reactome: R-HSA-6798695;Reactome: R-HSA-8856825	"Golgi Associated Vesicle Biogenesis";"Clathrin-mediated endocytosis";"Retrograde transport at the Trans-Golgi-Network";"Neutrophil degranulation";"Cargo recognition for clathrin-mediated endocytosis"
XP_046428808.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_046426755.1	1	Reactome: R-HSA-110320	"Translesion Synthesis by POLH"
XP_046416899.1	3	MetaCyc: PWY-7426;KEGG: 00510+2.4.1.144;Reactome: R-HSA-975574	"Complex N-linked glycan biosynthesis (vertebrates)";"N-Glycan biosynthesis";"Reactions specific to the hybrid N-glycan synthesis pathway"
XP_046419004.1	2	Reactome: R-HSA-5357905;Reactome: R-HSA-5357956	"Regulation of TNFR1 signaling";"TNFR1-induced NFkappaB signaling pathway"
XP_046411519.1	1	Reactome: R-HSA-6804759	"Regulation of TP53 Activity through Association with Co-factors"
XP_046431762.1	1	Reactome: R-HSA-1799339	"SRP-dependent cotranslational protein targeting to membrane"
XP_046413592.1	10	KEGG: 00030+2.7.1.11;KEGG: 00051+2.7.1.11;KEGG: 00052+2.7.1.11;MetaCyc: PWY-5484;Reactome: R-HSA-70171;KEGG: 00010+2.7.1.11;MetaCyc: PWY-1861;MetaCyc: PWY-1042;MetaCyc: PWY-7385;KEGG: 00680+2.7.1.11	"Pentose phosphate pathway";"Fructose and mannose metabolism";"Galactose metabolism";"Glycolysis II (from fructose 6-phosphate)";"Glycolysis";"Glycolysis / Gluconeogenesis";"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"Glycolysis IV (plant cytosol)";"1,3-propanediol biosynthesis (engineered)";"Methane metabolism"
XP_046418230.1	7	Reactome: R-HSA-2500257;Reactome: R-HSA-6811434;Reactome: R-HSA-5663220;Reactome: R-HSA-2467813;Reactome: R-HSA-68877;Reactome: R-HSA-141444;Reactome: R-HSA-9648025	"Resolution of Sister Chromatid Cohesion";"COPI-dependent Golgi-to-ER retrograde traffic";"RHO GTPases Activate Formins";"Separation of Sister Chromatids";"Mitotic Prometaphase";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"EML4 and NUDC in mitotic spindle formation"
XP_046427187.1	11	KEGG: 04714+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;Reactome: R-HSA-2559580;Reactome: R-HSA-171007;KEGG: 05163+2.7.11.1;Reactome: R-HSA-4420097;Reactome: R-HSA-450302;KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1	"Thermogenesis";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Oxidative Stress Induced Senescence";"p38MAPK events";"Human cytomegalovirus infection";"VEGFA-VEGFR2 Pathway";"activated TAK1 mediates p38 MAPK activation";"Relaxin signaling pathway";"PI3K-Akt signaling pathway";"mTOR signaling pathway"
XP_046412036.1	29	Reactome: R-HSA-112382;Reactome: R-HSA-73863;Reactome: R-HSA-76042;Reactome: R-HSA-167172;Reactome: R-HSA-75955;Reactome: R-HSA-73772;Reactome: R-HSA-167161;Reactome: R-HSA-167152;Reactome: R-HSA-5696395;Reactome: R-HSA-72086;Reactome: R-HSA-674695;Reactome: R-HSA-73776;Reactome: R-HSA-77075;Reactome: R-HSA-6796648;Reactome: R-HSA-167200;Reactome: R-HSA-6782210;Reactome: R-HSA-113418;Reactome: R-HSA-75953;Reactome: R-HSA-427413;Reactome: R-HSA-6781823;Reactome: R-HSA-167246;Reactome: R-HSA-167162;Reactome: R-HSA-73762;Reactome: R-HSA-167160;Reactome: R-HSA-6781827;Reactome: R-HSA-5696400;Reactome: R-HSA-167158;Reactome: R-HSA-73779;Reactome: R-HSA-6782135	"Formation of RNA Pol II elongation complex";"RNA Polymerase I Transcription Termination";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Transcription of the HIV genome";"RNA Polymerase II Transcription Elongation";"RNA Polymerase I Promoter Escape";"HIV Transcription Initiation";"Formation of HIV elongation complex in the absence of HIV Tat";"Formation of Incision Complex in GG-NER";"mRNA Capping";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Promoter Escape";"RNA Pol II CTD phosphorylation and interaction with CE";"TP53 Regulates Transcription of DNA Repair Genes";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Formation of the Early Elongation Complex";"RNA Polymerase II Transcription Initiation";"NoRC negatively regulates rRNA expression";"Formation of TC-NER Pre-Incision Complex";"Tat-mediated elongation of the HIV-1 transcript";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase I Transcription Initiation";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Dual Incision in GG-NER";"Formation of the HIV-1 Early Elongation Complex";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Dual incision in TC-NER"
XP_046426430.1	9	Reactome: R-HSA-5678895;Reactome: R-HSA-8856828;Reactome: R-HSA-382556;Reactome: R-HSA-5627083;Reactome: R-HSA-9646399;Reactome: R-HSA-5689880;Reactome: R-HSA-9615710;Reactome: R-HSA-8856825;Reactome: R-HSA-9613829	"Defective CFTR causes cystic fibrosis";"Clathrin-mediated endocytosis";"ABC-family proteins mediated transport";"RHO GTPases regulate CFTR trafficking";"Aggrephagy";"Ub-specific processing proteases";"Late endosomal microautophagy";"Cargo recognition for clathrin-mediated endocytosis";"Chaperone Mediated Autophagy"
XP_046435049.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_046428605.1	2	KEGG: 00970+6.1.1.4;Reactome: R-HSA-379726	"Aminoacyl-tRNA biosynthesis";"Mitochondrial tRNA aminoacylation"
XP_046413668.1	6	MetaCyc: PWY-7782;MetaCyc: PWY-5884;MetaCyc: PWY-7656;KEGG: 00073+1.2.1.84;MetaCyc: PWY-6733;Reactome: R-HSA-9640463	"Plasmalogen biosynthesis";"Wax esters biosynthesis I";"Spodoptera littoralis pheromone biosynthesis";"Cutin, suberine and wax biosynthesis";"Sporopollenin precursors biosynthesis";"Wax biosynthesis"
XP_046433900.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_046425182.1	1	Reactome: R-HSA-4615885	"SUMOylation of DNA replication proteins"
XP_046413639.1	4	Reactome: R-HSA-446203;Reactome: R-HSA-6798695;Reactome: R-HSA-879415;Reactome: R-HSA-1799339	"Asparagine N-linked glycosylation";"Neutrophil degranulation";"Advanced glycosylation endproduct receptor signaling";"SRP-dependent cotranslational protein targeting to membrane"
XP_046418439.1	1	Reactome: R-HSA-3238698	"WNT ligand biogenesis and trafficking"
XP_046433505.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_046425455.1	3	Reactome: R-HSA-8939243;Reactome: R-HSA-8943724;Reactome: R-HSA-2559580	"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"Regulation of PTEN gene transcription";"Oxidative Stress Induced Senescence"
XP_046431872.1	8	Reactome: R-HSA-8856828;Reactome: R-HSA-432720;Reactome: R-HSA-3928665;Reactome: R-HSA-196025;Reactome: R-HSA-5140745;Reactome: R-HSA-5099900;Reactome: R-HSA-8856825;Reactome: R-HSA-190873	"Clathrin-mediated endocytosis";"Lysosome Vesicle Biogenesis";"EPH-ephrin mediated repulsion of cells";"Formation of annular gap junctions";"WNT5A-dependent internalization of FZD2, FZD5 and ROR2";"WNT5A-dependent internalization of FZD4";"Cargo recognition for clathrin-mediated endocytosis";"Gap junction degradation"
XP_046414122.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_046419846.1	3	KEGG: 00730+3.1.3.2;MetaCyc: PWY-6348;KEGG: 00740+3.1.3.2	"Thiamine metabolism";"Phosphate acquisition";"Riboflavin metabolism"
XP_046426862.1	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276	"Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination"
XP_046415382.1	1	Reactome: R-HSA-111957	"Cam-PDE 1 activation"
XP_046431378.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046428537.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_046420528.1	3	Reactome: R-HSA-948021;Reactome: R-HSA-5694530;Reactome: R-HSA-204005	"Transport to the Golgi and subsequent modification";"Cargo concentration in the ER";"COPII-mediated vesicle transport"
XP_046431653.1	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
XP_046410116.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
XP_046417405.1	1	Reactome: R-HSA-432047	"Passive transport by Aquaporins"
XP_046419057.1	1	Reactome: R-HSA-196843	"Vitamin B2 (riboflavin) metabolism"
XP_046409870.1	1	Reactome: R-HSA-204005	"COPII-mediated vesicle transport"
XP_046425873.1	3	Reactome: R-HSA-418359;Reactome: R-HSA-936837;Reactome: R-HSA-5578775	"Reduction of cytosolic Ca++ levels";"Ion transport by P-type ATPases";"Ion homeostasis"
XP_046421293.1	3	Reactome: R-HSA-5423646;Reactome: R-HSA-2142691;MetaCyc: PWY-7533	"Aflatoxin activation and detoxification";"Synthesis of Leukotrienes (LT) and Eoxins (EX)";"Gliotoxin biosynthesis"
XP_046419598.1	3	KEGG: 00010+5.1.3.3;KEGG: 00052+5.1.3.3;MetaCyc: PWY-6317	"Glycolysis / Gluconeogenesis";"Galactose metabolism";"D-galactose degradation I (Leloir pathway)"
XP_046421338.1	7	KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1	"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Relaxin signaling pathway";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Human cytomegalovirus infection";"Thermogenesis"
XP_046422654.1	4	Reactome: R-HSA-73856;Reactome: R-HSA-72163;Reactome: R-HSA-159236;Reactome: R-HSA-72187	"RNA Polymerase II Transcription Termination";"mRNA Splicing - Major Pathway";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"mRNA 3'-end processing"
XP_046411906.1	2	Reactome: R-HSA-427413;Reactome: R-HSA-3214847	"NoRC negatively regulates rRNA expression";"HATs acetylate histones"
XP_046436322.1	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
XP_046416875.1	42	Reactome: R-HSA-73772;Reactome: R-HSA-8936459;Reactome: R-HSA-2299718;Reactome: R-HSA-110329;Reactome: R-HSA-9610379;Reactome: R-HSA-1912408;Reactome: R-HSA-3214841;Reactome: R-HSA-212300;Reactome: R-HSA-4551638;Reactome: R-HSA-171306;Reactome: R-HSA-5693565;Reactome: R-HSA-5250924;Reactome: R-HSA-427389;Reactome: R-HSA-606279;Reactome: R-HSA-3214847;Reactome: R-HSA-8939236;Reactome: R-HSA-3214842;Reactome: R-HSA-3214815;Reactome: R-HSA-9616222;Reactome: R-HSA-427413;Reactome: R-HSA-2559580;Reactome: R-HSA-110331;Reactome: R-HSA-3214858;Reactome: R-HSA-5693607;Reactome: R-HSA-2559582;Reactome: R-HSA-9609690;Reactome: R-HSA-5693571;Reactome: R-HSA-9018519;Reactome: R-HSA-69473;Reactome: R-HSA-110328;Reactome: R-HSA-5617472;Reactome: R-HSA-5625886;Reactome: R-HSA-73728;Reactome: R-HSA-1221632;Reactome: R-HSA-201722;Reactome: R-HSA-977225;Reactome: R-HSA-5578749;Reactome: R-HSA-427359;Reactome: R-HSA-5334118;Reactome: R-HSA-2559586;Reactome: R-HSA-912446;Reactome: R-HSA-110330	"RNA Polymerase I Promoter Escape";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Condensation of Prophase Chromosomes";"Cleavage of the damaged pyrimidine";"HCMV Late Events";"Pre-NOTCH Transcription and Translation";"PKMTs methylate histone lysines";"PRC2 methylates histones and DNA";"SUMOylation of chromatin organization proteins";"Packaging Of Telomere Ends";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"B-WICH complex positively regulates rRNA expression";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"Deposition of new CENPA-containing nucleosomes at the centromere";"HATs acetylate histones";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"HDMs demethylate histones";"HDACs deacetylate histones";"Transcriptional regulation of granulopoiesis";"NoRC negatively regulates rRNA expression";"Oxidative Stress Induced Senescence";"Cleavage of the damaged purine";"RMTs methylate histone arginines";"Processing of DNA double-strand break ends";"Senescence-Associated Secretory Phenotype (SASP)";"HCMV Early Events";"Nonhomologous End-Joining (NHEJ)";"Estrogen-dependent gene expression";"G2/M DNA damage checkpoint";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3";"RNA Polymerase I Promoter Opening";"Meiotic synapsis";"Formation of the beta-catenin:TCF transactivating complex";"Amyloid fiber formation";"Transcriptional regulation by small RNAs";"SIRT1 negatively regulates rRNA expression";"DNA methylation";"DNA Damage/Telomere Stress Induced Senescence";"Meiotic recombination";"Recognition and association of DNA glycosylase with site containing an affected purine"
XP_046415447.1	31	MetaCyc: PWY-6282;Reactome: R-HSA-75105;MetaCyc: PWY-5973;KEGG: 00061+1.1.1.100+2.3.1.85+4.2.1.59+2.3.1.39+2.3.1.41+3.1.2.14;MetaCyc: PWY-8047;MetaCyc: PWY-5989;MetaCyc: PWY-5147;MetaCyc: PWY-7723;MetaCyc: PWY-7746;MetaCyc: PWY-7858;Reactome: R-HSA-9029558;MetaCyc: PWY-5366;MetaCyc: PWY-6113;MetaCyc: PWY-5994;MetaCyc: PWY-5971;Reactome: R-HSA-163765;MetaCyc: PWY-7663;MetaCyc: PWY-6519;MetaCyc: PWY-4381;MetaCyc: PWY-6799;MetaCyc: PWY-5966-1;MetaCyc: PWY-7388;MetaCyc: PWY-5367;KEGG: 00780+1.1.1.100+4.2.1.59+2.3.1.41;MetaCyc: PWY-7664;MetaCyc: PWY-5142;Reactome: R-HSA-2426168;Reactome: R-HSA-199220;MetaCyc: PWY-8049;MetaCyc: PWY-8012;MetaCyc: PWYG-321	"Palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate)";"Fatty acyl-CoA biosynthesis";"Cis-vaccenate biosynthesis";"Fatty acid biosynthesis";"Bryostatin biosynthesis";"Stearate biosynthesis II (bacteria and plants)";"Oleate biosynthesis I (plants)";"Bacterial bioluminescence";"Mycobacterial sulfolipid biosynthesis";"(5Z)-dodecenoate biosynthesis II";"NR1H2 & NR1H3 regulate gene expression linked to lipogenesis";"Palmitoleate biosynthesis II (plants and bacteria)";"Superpathway of mycolate biosynthesis";"Palmitate biosynthesis (animals and fungi, cytoplasm)";"Palmitate biosynthesis II (bacteria and plant cytoplasm)";"ChREBP activates metabolic gene expression";"Gondoate biosynthesis (anaerobic)";"8-amino-7-oxononanoate biosynthesis I";"Fatty acid biosynthesis initiation (bacteria and plants)";"Fatty acid biosynthesis initiation (plant mitochondria)";"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)";"Octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast)";"Petroselinate biosynthesis";"Biotin metabolism";"Oleate biosynthesis IV (anaerobic)";"Acyl-[acyl-carrier protein] thioesterase pathway";"Activation of gene expression by SREBF (SREBP)";"Vitamin B5 (pantothenate) metabolism";"Pederin biosynthesis";"Mupirocin biosynthesis";""
XP_046423135.1	3	Reactome: R-HSA-8868766;Reactome: R-HSA-6784531;Reactome: R-HSA-6785470	"rRNA processing in the mitochondrion";"tRNA processing in the nucleus";"tRNA processing in the mitochondrion"
XP_046430987.1	4	KEGG: 05235+3.1.3.16;Reactome: R-HSA-180024;KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"DARPP-32 events";"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway"
XP_046414504.1	1	Reactome: R-HSA-9609523	"Insertion of tail-anchored proteins into the endoplasmic reticulum membrane"
XP_046426209.1	33	Reactome: R-HSA-165054;Reactome: R-HSA-4085377;Reactome: R-HSA-6784531;Reactome: R-HSA-170822;Reactome: R-HSA-180910;Reactome: R-HSA-141444;Reactome: R-HSA-159236;Reactome: R-HSA-9609690;Reactome: R-HSA-168325;Reactome: R-HSA-4570464;Reactome: R-HSA-159227;Reactome: R-HSA-168333;Reactome: R-HSA-5663220;Reactome: R-HSA-180746;Reactome: R-HSA-5578749;Reactome: R-HSA-68877;Reactome: R-HSA-3301854;Reactome: R-HSA-4551638;Reactome: R-HSA-3232142;Reactome: R-HSA-2500257;Reactome: R-HSA-3371453;Reactome: R-HSA-9648025;Reactome: R-HSA-3108214;Reactome: R-HSA-2467813;Reactome: R-HSA-159231;Reactome: R-HSA-1169408;Reactome: R-HSA-9610379;Reactome: R-HSA-168271;Reactome: R-HSA-159230;Reactome: R-HSA-191859;Reactome: R-HSA-4615885;Reactome: R-HSA-168276;Reactome: R-HSA-5619107	"Rev-mediated nuclear export of HIV RNA";"SUMOylation of SUMOylation proteins";"tRNA processing in the nucleus";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Vpr-mediated nuclear import of PICs";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"HCMV Early Events";"Viral Messenger RNA Synthesis";"SUMOylation of RNA binding proteins";"Transport of the SLBP independent Mature mRNA";"NEP/NS2 Interacts with the Cellular Export Machinery";"RHO GTPases Activate Formins";"Nuclear import of Rev protein";"Transcriptional regulation by small RNAs";"Mitotic Prometaphase";"Nuclear Pore Complex (NPC) Disassembly";"SUMOylation of chromatin organization proteins";"SUMOylation of ubiquitinylation proteins";"Resolution of Sister Chromatid Cohesion";"Regulation of HSF1-mediated heat shock response";"EML4 and NUDC in mitotic spindle formation";"SUMOylation of DNA damage response and repair proteins";"Separation of Sister Chromatids";"Transport of Mature mRNA Derived from an Intronless Transcript";"ISG15 antiviral mechanism";"HCMV Late Events";"Transport of Ribonucleoproteins into the Host Nucleus";"Transport of the SLBP Dependant Mature mRNA";"snRNP Assembly";"SUMOylation of DNA replication proteins";"NS1 Mediated Effects on Host Pathways";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)"
XP_046421618.1	3	MetaCyc: PWY-6369;Reactome: R-HSA-1855167;KEGG: 04070+2.7.4.24+2.7.4.21	"Inositol diphosphates biosynthesis";"Synthesis of pyrophosphates in the cytosol";"Phosphatidylinositol signaling system"
XP_046410603.1	5	Reactome: R-HSA-427413;Reactome: R-HSA-73772;Reactome: R-HSA-73762;Reactome: R-HSA-5250924;Reactome: R-HSA-73863	"NoRC negatively regulates rRNA expression";"RNA Polymerase I Promoter Escape";"RNA Polymerase I Transcription Initiation";"B-WICH complex positively regulates rRNA expression";"RNA Polymerase I Transcription Termination"
XP_046412232.1	1	Reactome: R-HSA-8866654	"E3 ubiquitin ligases ubiquitinate target proteins"
XP_046411460.1	5	MetaCyc: PWY-7268;Reactome: R-HSA-196807;MetaCyc: PWY-5083;MetaCyc: PWY-7269;KEGG: 00760+2.7.1.23	"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"Nicotinate metabolism";"NAD/NADH phosphorylation and dephosphorylation";"NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)";"Nicotinate and nicotinamide metabolism"
XP_046423833.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046428752.1	5	Reactome: R-HSA-168164;Reactome: R-HSA-937041;Reactome: R-HSA-936964;Reactome: R-HSA-937072;Reactome: R-HSA-166166	"Toll Like Receptor 3 (TLR3) Cascade";"IKK complex recruitment mediated by RIP1";"Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon";"TRAF6-mediated induction of TAK1 complex within TLR4 complex";"MyD88-independent TLR4 cascade"
XP_046433589.1	2	Reactome: R-HSA-5619061;Reactome: R-HSA-425397	"Defective SLC33A1 causes spastic paraplegia 42 (SPG42)";"Transport of vitamins, nucleosides, and related molecules"
XP_046429935.1	5	KEGG: 00514+2.4.1.109;MetaCyc: PWY-7921;MetaCyc: PWY-7922;KEGG: 00515+2.4.1.109;MetaCyc: PWY-7979	"Other types of O-glycan biosynthesis";"Protein O-mannosylation I (yeast)";"Protein O-mannosylation II (mammals, core M1 and core M2)";"Mannose type O-glycan biosynthesis";"Protein O-mannosylation III (mammals, core M3)"
XP_046414610.1	1	Reactome: R-HSA-1660661	"Sphingolipid de novo biosynthesis"
XP_046432408.1	26	Reactome: R-HSA-5617833;Reactome: R-HSA-2132295;Reactome: R-HSA-9609736;Reactome: R-HSA-8955332;Reactome: R-HSA-9646399;Reactome: R-HSA-190861;Reactome: R-HSA-6811436;Reactome: R-HSA-190840;Reactome: R-HSA-68877;Reactome: R-HSA-8852276;Reactome: R-HSA-437239;Reactome: R-HSA-389977;Reactome: R-HSA-5663220;Reactome: R-HSA-3371497;Reactome: R-HSA-6811434;Reactome: R-HSA-380320;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813;Reactome: R-HSA-9609690;Reactome: R-HSA-9619483;Reactome: R-HSA-389960;Reactome: R-HSA-983189;Reactome: R-HSA-2500257;Reactome: R-HSA-1445148;Reactome: R-HSA-5626467;Reactome: R-HSA-6807878	"Cilium Assembly";"MHC class II antigen presentation";"Assembly and cell surface presentation of NMDA receptors";"Carboxyterminal post-translational modifications of tubulin";"Aggrephagy";"Gap junction assembly";"COPI-independent Golgi-to-ER retrograde traffic";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Mitotic Prometaphase";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Recycling pathway of L1";"Post-chaperonin tubulin folding pathway";"RHO GTPases Activate Formins";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-dependent Golgi-to-ER retrograde traffic";"Recruitment of NuMA to mitotic centrosomes";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids";"HCMV Early Events";"Activation of AMPK downstream of NMDARs";"Formation of tubulin folding intermediates by CCT/TriC";"Kinesins";"Resolution of Sister Chromatid Cohesion";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"RHO GTPases activate IQGAPs";"COPI-mediated anterograde transport"
XP_046436719.1	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
XP_046413429.1	11	Reactome: R-HSA-1963642;Reactome: R-HSA-8863795;Reactome: R-HSA-6811558;Reactome: R-HSA-1250196;Reactome: R-HSA-9664565;Reactome: R-HSA-1257604;Reactome: R-HSA-8847993;Reactome: R-HSA-1227986;Reactome: R-HSA-5673001;Reactome: R-HSA-6785631;Reactome: R-HSA-2219530	"PI3K events in ERBB2 signaling";"Downregulation of ERBB2 signaling";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"SHC1 events in ERBB2 signaling";"Signaling by ERBB2 KD Mutants";"PIP3 activates AKT signaling";"ERBB2 Activates PTK6 Signaling";"Signaling by ERBB2";"RAF/MAP kinase cascade";"ERBB2 Regulates Cell Motility";"Constitutive Signaling by Aberrant PI3K in Cancer"
XP_046427453.1	11	MetaCyc: PWY-7586;KEGG: 00051+5.3.1.8;MetaCyc: PWY-5659;MetaCyc: PWY-6992;MetaCyc: PWY-7456;MetaCyc: PWY-3861;Reactome: R-HSA-446205;MetaCyc: PWY-3881;MetaCyc: PWY-882;Reactome: R-HSA-4043916;KEGG: 00520+5.3.1.8	"Beta-1,4-d-mannosyl-n-acetyl-d-glucosamine degradation";"Fructose and mannose metabolism";"GDP-mannose biosynthesis";"1,5-anhydrofructose degradation";"Beta-(1,4)-mannan degradation";"Mannitol degradation II";"Synthesis of GDP-mannose";"Mannitol biosynthesis";"L-ascorbate biosynthesis I (L-galactose pathway)";"Defective MPI causes MPI-CDG (CDG-1b)";"Amino sugar and nucleotide sugar metabolism"
XP_046426363.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046428633.1	7	Reactome: R-HSA-8856828;Reactome: R-HSA-1855183;Reactome: R-HSA-1660499;KEGG: 04070+3.1.3.36;KEGG: 00562+3.1.3.36;MetaCyc: PWY-6368;Reactome: R-HSA-1855204	"Clathrin-mediated endocytosis";"Synthesis of IP2, IP, and Ins in the cytosol";"Synthesis of PIPs at the plasma membrane";"Phosphatidylinositol signaling system";"Inositol phosphate metabolism";"3-phosphoinositide degradation";"Synthesis of IP3 and IP4 in the cytosol"
XP_046424078.1	1	Reactome: R-HSA-5676934	"Protein repair"
XP_046434698.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_046425879.1	3	Reactome: R-HSA-936837;Reactome: R-HSA-5578775;Reactome: R-HSA-418359	"Ion transport by P-type ATPases";"Ion homeostasis";"Reduction of cytosolic Ca++ levels"
XP_046427860.1	33	Reactome: R-HSA-4570464;Reactome: R-HSA-159236;Reactome: R-HSA-141444;Reactome: R-HSA-9609690;Reactome: R-HSA-168325;Reactome: R-HSA-170822;Reactome: R-HSA-180910;Reactome: R-HSA-165054;Reactome: R-HSA-4085377;Reactome: R-HSA-6784531;Reactome: R-HSA-3301854;Reactome: R-HSA-180746;Reactome: R-HSA-5578749;Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-168333;Reactome: R-HSA-159227;Reactome: R-HSA-9610379;Reactome: R-HSA-9648025;Reactome: R-HSA-159231;Reactome: R-HSA-1169408;Reactome: R-HSA-2467813;Reactome: R-HSA-3108214;Reactome: R-HSA-3232142;Reactome: R-HSA-3371453;Reactome: R-HSA-2500257;Reactome: R-HSA-4551638;Reactome: R-HSA-168276;Reactome: R-HSA-5619107;Reactome: R-HSA-159230;Reactome: R-HSA-191859;Reactome: R-HSA-4615885;Reactome: R-HSA-168271	"SUMOylation of RNA binding proteins";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"HCMV Early Events";"Viral Messenger RNA Synthesis";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Vpr-mediated nuclear import of PICs";"Rev-mediated nuclear export of HIV RNA";"SUMOylation of SUMOylation proteins";"tRNA processing in the nucleus";"Nuclear Pore Complex (NPC) Disassembly";"Nuclear import of Rev protein";"Transcriptional regulation by small RNAs";"Mitotic Prometaphase";"RHO GTPases Activate Formins";"NEP/NS2 Interacts with the Cellular Export Machinery";"Transport of the SLBP independent Mature mRNA";"HCMV Late Events";"EML4 and NUDC in mitotic spindle formation";"Transport of Mature mRNA Derived from an Intronless Transcript";"ISG15 antiviral mechanism";"Separation of Sister Chromatids";"SUMOylation of DNA damage response and repair proteins";"SUMOylation of ubiquitinylation proteins";"Regulation of HSF1-mediated heat shock response";"Resolution of Sister Chromatid Cohesion";"SUMOylation of chromatin organization proteins";"NS1 Mediated Effects on Host Pathways";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Transport of the SLBP Dependant Mature mRNA";"snRNP Assembly";"SUMOylation of DNA replication proteins";"Transport of Ribonucleoproteins into the Host Nucleus"
XP_046421967.1	2	Reactome: R-HSA-1296052;Reactome: R-HSA-418457	"Ca2+ activated K+ channels";"cGMP effects"
XP_046414460.1	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286	"Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation"
XP_046421550.1	1	KEGG: 00480+3.4.11.2	"Glutathione metabolism"
XP_046435463.1	1	Reactome: R-HSA-1660661	"Sphingolipid de novo biosynthesis"
XP_046428700.1	16	Reactome: R-HSA-975956;Reactome: R-HSA-72702;Reactome: R-HSA-6791226;Reactome: R-HSA-2408557;Reactome: R-HSA-72706;Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-156902;Reactome: R-HSA-72764;Reactome: R-HSA-72649;Reactome: R-HSA-975957;Reactome: R-HSA-72695;Reactome: R-HSA-1799339;Reactome: R-HSA-72689;Reactome: R-HSA-192823	"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Ribosomal scanning and start codon recognition";"Major pathway of rRNA processing in the nucleolus and cytosol";"Selenocysteine synthesis";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Peptide chain elongation";"Eukaryotic Translation Termination";"Translation initiation complex formation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Formation of the ternary complex, and subsequently, the 43S complex";"SRP-dependent cotranslational protein targeting to membrane";"Formation of a pool of free 40S subunits";"Viral mRNA Translation"
XP_046421184.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046423668.1	1	Reactome: R-HSA-196843	"Vitamin B2 (riboflavin) metabolism"
XP_046421956.1	2	Reactome: R-HSA-1296052;Reactome: R-HSA-418457	"Ca2+ activated K+ channels";"cGMP effects"
XP_046424474.1	6	Reactome: R-HSA-9640463;MetaCyc: PWY-6733;MetaCyc: PWY-7656;KEGG: 00073+1.2.1.84;MetaCyc: PWY-5884;MetaCyc: PWY-7782	"Wax biosynthesis";"Sporopollenin precursors biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax esters biosynthesis I";"Plasmalogen biosynthesis"
XP_046422272.1	4	Reactome: R-HSA-975144;Reactome: R-HSA-937039;Reactome: R-HSA-9020702;MetaCyc: PWY-7511	"IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation";"IRAK1 recruits IKK complex";"Interleukin-1 signaling";"Protein ubiquitination"
XP_046435861.1	2	Reactome: R-HSA-6804115;Reactome: R-HSA-429947	"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Deadenylation of mRNA"
XP_046420206.1	7	MetaCyc: PWY-5469;MetaCyc: PWY-5466;MetaCyc: PWY-7445;MetaCyc: PWY-7214;KEGG: 00940+1.11.1.7;MetaCyc: PWY-6824;MetaCyc: PWY-5461	"Sesamin biosynthesis";"Matairesinol biosynthesis";"Luteolin triglucuronide degradation";"Baicalein degradation (hydrogen peroxide detoxification)";"Phenylpropanoid biosynthesis";"Justicidin B biosynthesis";"Betanidin degradation"
XP_046410730.1	4	Reactome: R-HSA-112308;Reactome: R-HSA-5576893;Reactome: R-HSA-419037;Reactome: R-HSA-5576892	"Presynaptic depolarization and calcium channel opening";"Phase 2 - plateau phase";"NCAM1 interactions";"Phase 0 - rapid depolarisation"
XP_046424499.1	2	Reactome: R-HSA-8964539;Reactome: R-HSA-2151201	"Glutamate and glutamine metabolism";"Transcriptional activation of mitochondrial biogenesis"
XP_046424485.1	6	MetaCyc: PWY-7782;MetaCyc: PWY-5884;MetaCyc: PWY-6733;Reactome: R-HSA-9640463;MetaCyc: PWY-7656;KEGG: 00073+1.2.1.84	"Plasmalogen biosynthesis";"Wax esters biosynthesis I";"Sporopollenin precursors biosynthesis";"Wax biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Cutin, suberine and wax biosynthesis"
XP_046413232.1	1	Reactome: R-HSA-70221	"Glycogen breakdown (glycogenolysis)"
XP_046436670.1	12	Reactome: R-HSA-9648025;Reactome: R-HSA-141444;Reactome: R-HSA-68877;Reactome: R-HSA-9609690;Reactome: R-HSA-6811436;Reactome: R-HSA-2467813;Reactome: R-HSA-9646399;Reactome: R-HSA-2132295;Reactome: R-HSA-3371497;Reactome: R-HSA-6807878;Reactome: R-HSA-5663220;Reactome: R-HSA-2500257	"EML4 and NUDC in mitotic spindle formation";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Mitotic Prometaphase";"HCMV Early Events";"COPI-independent Golgi-to-ER retrograde traffic";"Separation of Sister Chromatids";"Aggrephagy";"MHC class II antigen presentation";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-mediated anterograde transport";"RHO GTPases Activate Formins";"Resolution of Sister Chromatid Cohesion"
XP_046420435.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
XP_046421985.1	2	Reactome: R-HSA-1296052;Reactome: R-HSA-418457	"Ca2+ activated K+ channels";"cGMP effects"
XP_046418919.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046410888.1	3	KEGG: 00230+1.7.3.3;MetaCyc: PWY-5691;KEGG: 00232+1.7.3.3	"Purine metabolism";"Urate conversion to allantoin I";"Caffeine metabolism"
XP_046421317.1	7	KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1	"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Thermogenesis";"Human cytomegalovirus infection";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Relaxin signaling pathway"
XP_046430927.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_046412950.1	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
XP_046435163.1	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
XP_046427365.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046435920.1	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
XP_046415309.1	2	KEGG: 00500+2.4.1.15;Reactome: R-HSA-446205	"Starch and sucrose metabolism";"Synthesis of GDP-mannose"
XP_046415853.1	7	KEGG: 00670+1.5.1.3;Reactome: R-HSA-1474151;KEGG: 00790+1.5.1.3;MetaCyc: PWY-6614;MetaCyc: PWY-3841;Reactome: R-HSA-69205;Reactome: R-HSA-196757	"One carbon pool by folate";"Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation";"Folate biosynthesis";"Tetrahydrofolate biosynthesis";"Folate transformations II (plants)";"G1/S-Specific Transcription";"Metabolism of folate and pterines"
XP_046434583.1	3	Reactome: R-HSA-418597;KEGG: 04070+2.7.11.13;Reactome: R-HSA-114508	"G alpha (z) signalling events";"Phosphatidylinositol signaling system";"Effects of PIP2 hydrolysis"
XP_046434646.1	1	Reactome: R-HSA-209968	"Thyroxine biosynthesis"
XP_046427420.1	9	KEGG: 04926+2.7.11.1;Reactome: R-HSA-6804756;KEGG: 05163+2.7.11.1;Reactome: R-HSA-6782315;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1	"Relaxin signaling pathway";"Regulation of TP53 Activity through Phosphorylation";"Human cytomegalovirus infection";"tRNA modification in the nucleus and cytosol";"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Thermogenesis"
XP_046420141.1	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840	"Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation"
XP_046414585.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046409694.1	1	Reactome: R-HSA-112126	"ALKBH3 mediated reversal of alkylation damage"
XP_046410580.1	2	Reactome: R-HSA-5218920;Reactome: R-HSA-418990	"VEGFR2 mediated vascular permeability";"Adherens junctions interactions"
XP_046410313.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_046426030.1	1	Reactome: R-HSA-2564830	"Cytosolic iron-sulfur cluster assembly"
XP_046428264.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046435701.1	1	Reactome: R-HSA-1237044	"Erythrocytes take up carbon dioxide and release oxygen"
XP_046414899.1	1	Reactome: R-HSA-204626	"Hypusine synthesis from eIF5A-lysine"
XP_046419120.1	1	Reactome: R-HSA-382556	"ABC-family proteins mediated transport"
XP_046428834.1	1	Reactome: R-HSA-191859	"snRNP Assembly"
XP_046409892.1	1	Reactome: R-HSA-77289	"Mitochondrial Fatty Acid Beta-Oxidation"
XP_046421678.1	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
XP_046419246.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046434585.1	22	Reactome: R-HSA-389513;Reactome: R-HSA-2500257;Reactome: R-HSA-5673000;Reactome: R-HSA-2467813;Reactome: R-HSA-195253;Reactome: R-HSA-5358752;Reactome: R-HSA-9648025;Reactome: R-HSA-5358751;Reactome: R-HSA-141444;Reactome: R-HSA-5358747;Reactome: R-HSA-5467340;Reactome: R-HSA-6811558;Reactome: R-HSA-196299;Reactome: R-HSA-5358749;Reactome: R-HSA-5663220;Reactome: R-HSA-5467348;Reactome: R-HSA-5467337;Reactome: R-HSA-68877;Reactome: R-HSA-4641262;Reactome: R-HSA-5339716;Reactome: R-HSA-5675221;Reactome: R-HSA-432142	"CTLA4 inhibitory signaling";"Resolution of Sister Chromatid Cohesion";"RAF activation";"Separation of Sister Chromatids";"Degradation of beta-catenin by the destruction complex";"T41 mutants of beta-catenin aren't phosphorylated";"EML4 and NUDC in mitotic spindle formation";"S45 mutants of beta-catenin aren't phosphorylated";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"S33 mutants of beta-catenin aren't phosphorylated";"AXIN missense mutants destabilize the destruction complex";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"Beta-catenin phosphorylation cascade";"S37 mutants of beta-catenin aren't phosphorylated";"RHO GTPases Activate Formins";"Truncations of AMER1 destabilize the destruction complex";"APC truncation mutants have impaired AXIN binding";"Mitotic Prometaphase";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"Misspliced GSK3beta mutants stabilize beta-catenin";"Negative regulation of MAPK pathway";"Platelet sensitization by LDL"
XP_046413621.1	1	Reactome: R-HSA-6809371	"Formation of the cornified envelope"
XP_046432261.1	3	Reactome: R-HSA-212436;Reactome: R-HSA-1989781;Reactome: R-HSA-381340	"Generic Transcription Pathway";"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation"
XP_046415959.1	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
XP_046419400.1	1	Reactome: R-HSA-1614517	"Sulfide oxidation to sulfate"
XP_046432614.1	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
XP_046411239.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046420552.1	2	Reactome: R-HSA-416476;Reactome: R-HSA-388479	"G alpha (q) signalling events";"Vasopressin-like receptors"
XP_046435784.1	12	Reactome: R-HSA-5620912;Reactome: R-HSA-3371497;Reactome: R-HSA-380270;Reactome: R-HSA-8854518;Reactome: R-HSA-6807878;Reactome: R-HSA-381038;Reactome: R-HSA-2132295;Reactome: R-HSA-380284;Reactome: R-HSA-380320;Reactome: R-HSA-2565942;Reactome: R-HSA-6811436;Reactome: R-HSA-380259	"Anchoring of the basal body to the plasma membrane";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Recruitment of mitotic centrosome proteins and complexes";"AURKA Activation by TPX2";"COPI-mediated anterograde transport";"XBP1(S) activates chaperone genes";"MHC class II antigen presentation";"Loss of proteins required for interphase microtubule organization from the centrosome";"Recruitment of NuMA to mitotic centrosomes";"Regulation of PLK1 Activity at G2/M Transition";"COPI-independent Golgi-to-ER retrograde traffic";"Loss of Nlp from mitotic centrosomes"
XP_046416940.1	8	KEGG: 00195+7.1.2.2;Reactome: R-HSA-77387;Reactome: R-HSA-9639288;MetaCyc: PWY-7980;KEGG: 00190+7.1.2.2;Reactome: R-HSA-983712;Reactome: R-HSA-1222556;Reactome: R-HSA-917977	"Photosynthesis";"Insulin receptor recycling";"Amino acids regulate mTORC1";"ATP biosynthesis";"Oxidative phosphorylation";"Ion channel transport";"ROS and RNS production in phagocytes";"Transferrin endocytosis and recycling"
XP_046422894.1	1	Reactome: R-HSA-427652	"Sodium-coupled phosphate cotransporters"
XP_046419401.1	1	Reactome: R-HSA-1614517	"Sulfide oxidation to sulfate"
XP_046427643.1	1	Reactome: R-HSA-912446	"Meiotic recombination"
XP_046417739.1	2	Reactome: R-HSA-416993;Reactome: R-HSA-202733	"Trafficking of GluR2-containing AMPA receptors";"Cell surface interactions at the vascular wall"
XP_046417618.1	2	Reactome: R-HSA-416476;Reactome: R-HSA-375281	"G alpha (q) signalling events";"Hormone ligand-binding receptors"
XP_046430384.1	7	Reactome: R-HSA-1632852;Reactome: R-HSA-166208;Reactome: R-HSA-165159;Reactome: R-HSA-380972;Reactome: R-HSA-5628897;Reactome: R-HSA-9639288;Reactome: R-HSA-8943724	"Macroautophagy";"mTORC1-mediated signalling";"mTOR signalling";"Energy dependent regulation of mTOR by LKB1-AMPK";"TP53 Regulates Metabolic Genes";"Amino acids regulate mTORC1";"Regulation of PTEN gene transcription"
XP_046436408.1	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
XP_046412229.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046415875.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_046432187.1	1	Reactome: R-HSA-1296052	"Ca2+ activated K+ channels"
XP_046412230.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046430994.1	2	Reactome: R-HSA-389661;Reactome: R-HSA-2408508	"Glyoxylate metabolism and glycine degradation";"Metabolism of ingested SeMet, Sec, MeSec into H2Se"
XP_046428754.1	5	Reactome: R-HSA-168164;Reactome: R-HSA-937041;Reactome: R-HSA-936964;Reactome: R-HSA-166166;Reactome: R-HSA-937072	"Toll Like Receptor 3 (TLR3) Cascade";"IKK complex recruitment mediated by RIP1";"Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon";"MyD88-independent TLR4 cascade";"TRAF6-mediated induction of TAK1 complex within TLR4 complex"
XP_046413253.1	7	KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04926+2.7.11.1	"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Thermogenesis";"Human cytomegalovirus infection";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Relaxin signaling pathway"
XP_046436472.1	2	Reactome: R-HSA-6807878;Reactome: R-HSA-445095	"COPI-mediated anterograde transport";"Interaction between L1 and Ankyrins"
XP_046413250.1	1	Reactome: R-HSA-6811440	"Retrograde transport at the Trans-Golgi-Network"
XP_046425858.1	18	Reactome: R-HSA-5693565;Reactome: R-HSA-3108214;Reactome: R-HSA-5689901;Reactome: R-HSA-6804756;Reactome: R-HSA-5693571;Reactome: R-HSA-69473;Reactome: R-HSA-5693616;Reactome: R-HSA-6796648;Reactome: R-HSA-5693568;Reactome: R-HSA-5693579;Reactome: R-HSA-5685942;Reactome: R-HSA-912446;Reactome: R-HSA-5693607;Reactome: R-HSA-1221632;Reactome: R-HSA-8953750;MetaCyc: PWY-7511;Reactome: R-HSA-5685938;Reactome: R-HSA-5693554	"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"SUMOylation of DNA damage response and repair proteins";"Metalloprotease DUBs";"Regulation of TP53 Activity through Phosphorylation";"Nonhomologous End-Joining (NHEJ)";"G2/M DNA damage checkpoint";"Presynaptic phase of homologous DNA pairing and strand exchange";"TP53 Regulates Transcription of DNA Repair Genes";"Resolution of D-loop Structures through Holliday Junction Intermediates";"Homologous DNA Pairing and Strand Exchange";"HDR through Homologous Recombination (HRR)";"Meiotic recombination";"Processing of DNA double-strand break ends";"Meiotic synapsis";"Transcriptional Regulation by E2F6";"Protein ubiquitination";"HDR through Single Strand Annealing (SSA)";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)"
XP_046418357.1	5	Reactome: R-HSA-6798695;Reactome: R-HSA-3134975;Reactome: R-HSA-3270619;Reactome: R-HSA-3249367;Reactome: R-HSA-1834941	"Neutrophil degranulation";"Regulation of innate immune responses to cytosolic DNA";"IRF3-mediated induction of type I IFN";"STAT6-mediated induction of chemokines";"STING mediated induction of host immune responses"
XP_046432855.1	8	MetaCyc: PWY-1861;Reactome: R-HSA-8950505;Reactome: R-HSA-6791462;KEGG: 00030+2.2.1.2;Reactome: R-HSA-71336;Reactome: R-HSA-163754;MetaCyc: PWY-5723;Reactome: R-HSA-6791055	"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation";"TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P";"Pentose phosphate pathway";"Pentose phosphate pathway";"Insulin effects increased synthesis of Xylulose-5-Phosphate";"Rubisco shunt";"TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P"
XP_046428082.1	4	Reactome: R-HSA-5578775;Reactome: R-HSA-936837;Reactome: R-HSA-1912420;Reactome: R-HSA-418359	"Ion homeostasis";"Ion transport by P-type ATPases";"Pre-NOTCH Processing in Golgi";"Reduction of cytosolic Ca++ levels"
XP_046430298.1	6	Reactome: R-HSA-176187;Reactome: R-HSA-68867;Reactome: R-HSA-176974;Reactome: R-HSA-69052;Reactome: R-HSA-68949;Reactome: R-HSA-68962	"Activation of ATR in response to replication stress";"Assembly of the pre-replicative complex";"Unwinding of DNA";"Switching of origins to a post-replicative state";"Orc1 removal from chromatin";"Activation of the pre-replicative complex"
XP_046417962.1	1	Reactome: R-HSA-428890	"Role of ABL in ROBO-SLIT signaling"
XP_046412392.1	1	Reactome: R-HSA-9609523	"Insertion of tail-anchored proteins into the endoplasmic reticulum membrane"
XP_046419242.1	5	Reactome: R-HSA-1445148;Reactome: R-HSA-6811434;Reactome: R-HSA-2132295;Reactome: R-HSA-983189;Reactome: R-HSA-5620924	"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"COPI-dependent Golgi-to-ER retrograde traffic";"MHC class II antigen presentation";"Kinesins";"Intraflagellar transport"
XP_046433603.1	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
XP_046429050.1	5	Reactome: R-HSA-5693571;Reactome: R-HSA-1834949;Reactome: R-HSA-6798695;Reactome: R-HSA-3270619;Reactome: R-HSA-164843	"Nonhomologous End-Joining (NHEJ)";"Cytosolic sensors of pathogen-associated DNA";"Neutrophil degranulation";"IRF3-mediated induction of type I IFN";"2-LTR circle formation"
XP_046415048.1	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
XP_046435082.1	7	KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1	"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Relaxin signaling pathway";"Thermogenesis";"Human cytomegalovirus infection"
XP_046426912.1	1	Reactome: R-HSA-3238698	"WNT ligand biogenesis and trafficking"
XP_046427062.1	20	Reactome: R-HSA-8943724;Reactome: R-HSA-1632852;KEGG: 05165+2.7.11.1;Reactome: R-HSA-5218920;Reactome: R-HSA-165159;Reactome: R-HSA-380972;Reactome: R-HSA-5674400;Reactome: R-HSA-1257604;Reactome: R-HSA-6804757;Reactome: R-HSA-3371571;KEGG: 05163+2.7.11.1;Reactome: R-HSA-389357;KEGG: 04926+2.7.11.1;Reactome: R-HSA-5628897;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;Reactome: R-HSA-9639288;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;Reactome: R-HSA-166208	"Regulation of PTEN gene transcription";"Macroautophagy";"Human papillomavirus infection";"VEGFR2 mediated vascular permeability";"mTOR signalling";"Energy dependent regulation of mTOR by LKB1-AMPK";"Constitutive Signaling by AKT1 E17K in Cancer";"PIP3 activates AKT signaling";"Regulation of TP53 Degradation";"HSF1-dependent transactivation";"Human cytomegalovirus infection";"CD28 dependent PI3K/Akt signaling";"Relaxin signaling pathway";"TP53 Regulates Metabolic Genes";"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Amino acids regulate mTORC1";"Thermogenesis";"Human immunodeficiency virus 1 infection";"mTORC1-mediated signalling"
XP_046416504.1	2	KEGG: 00260+2.1.2.10;KEGG: 00670+2.1.2.10	"Glycine, serine and threonine metabolism";"One carbon pool by folate"
XP_046434103.1	2	Reactome: R-HSA-426486;Reactome: R-HSA-203927	"Small interfering RNA (siRNA) biogenesis";"MicroRNA (miRNA) biogenesis"
XP_046433811.1	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
XP_046409411.1	2	Reactome: R-HSA-375276;Reactome: R-HSA-416476	"Peptide ligand-binding receptors";"G alpha (q) signalling events"
XP_046414309.1	56	Reactome: R-HSA-5607761;Reactome: R-HSA-5658442;Reactome: R-HSA-983168;Reactome: R-HSA-2467813;Reactome: R-HSA-174154;Reactome: R-HSA-8939902;Reactome: R-HSA-174184;Reactome: R-HSA-1236978;Reactome: R-HSA-75815;Reactome: R-HSA-202424;Reactome: R-HSA-4608870;Reactome: R-HSA-4641257;Reactome: R-HSA-5689880;Reactome: R-HSA-8951664;Reactome: R-HSA-174084;Reactome: R-HSA-349425;Reactome: R-HSA-8939236;Reactome: R-HSA-5678895;Reactome: R-HSA-180585;Reactome: R-HSA-5610785;Reactome: R-HSA-9010553;Reactome: R-HSA-8941858;Reactome: R-HSA-350562;Reactome: R-HSA-5668541;Reactome: R-HSA-450408;Reactome: R-HSA-5610780;Reactome: R-HSA-1236974;Reactome: R-HSA-211733;Reactome: R-HSA-4641258;Reactome: R-HSA-5632684;Reactome: R-HSA-1169091;Reactome: R-HSA-68949;Reactome: R-HSA-382556;Reactome: R-HSA-195253;Reactome: R-HSA-2871837;Reactome: R-HSA-174178;Reactome: R-HSA-5676590;Reactome: R-HSA-5362768;Reactome: R-HSA-9604323;Reactome: R-HSA-69017;Reactome: R-HSA-5358346;Reactome: R-HSA-69601;Reactome: R-HSA-174113;Reactome: R-HSA-5687128;Reactome: R-HSA-8854050;Reactome: R-HSA-9020702;Reactome: R-HSA-69481;Reactome: R-HSA-1234176;Reactome: R-HSA-8948751;Reactome: R-HSA-5610783;Reactome: R-HSA-8852276;Reactome: R-HSA-68827;Reactome: R-HSA-5689603;Reactome: R-HSA-180534;Reactome: R-HSA-187577;Reactome: R-HSA-5607764	"Dectin-1 mediated noncanonical NF-kB signaling";"Regulation of RAS by GAPs";"Antigen processing: Ubiquitination & Proteasome degradation";"Separation of Sister Chromatids";"APC/C:Cdc20 mediated degradation of Securin";"Regulation of RUNX2 expression and activity";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Cross-presentation of soluble exogenous antigens (endosomes)";"Ubiquitin-dependent degradation of Cyclin D";"Downstream TCR signaling";"Asymmetric localization of PCP proteins";"Degradation of AXIN";"Ub-specific processing proteases";"Neddylation";"Autodegradation of Cdh1 by Cdh1:APC/C";"Autodegradation of the E3 ubiquitin ligase COP1";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Defective CFTR causes cystic fibrosis";"Vif-mediated degradation of APOBEC3G";"GLI3 is processed to GLI3R by the proteasome";"Regulation of expression of SLITs and ROBOs";"Regulation of RUNX3 expression and activity";"Regulation of ornithine decarboxylase (ODC)";"TNFR2 non-canonical NF-kB pathway";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Degradation of GLI1 by the proteasome";"ER-Phagosome pathway";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Degradation of DVL";"Hedgehog 'on' state";"Activation of NF-kappaB in B cells";"Orc1 removal from chromatin";"ABC-family proteins mediated transport";"Degradation of beta-catenin by the destruction complex";"FCERI mediated NF-kB activation";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"NIK-->noncanonical NF-kB signaling";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Negative regulation of NOTCH4 signaling";"CDK-mediated phosphorylation and removal of Cdc6";"Hedgehog ligand biogenesis";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"SCF-beta-TrCP mediated degradation of Emi1";"MAPK6/MAPK4 signaling";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Interleukin-1 signaling";"G2/M Checkpoints";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of PTEN stability and activity";"Degradation of GLI2 by the proteasome";"The role of GTSE1 in G2/M progression after G2 checkpoint";"CDT1 association with the CDC6:ORC:origin complex";"UCH proteinases";"Vpu mediated degradation of CD4";"SCF(Skp2)-mediated degradation of p27/p21";"CLEC7A (Dectin-1) signaling"
XP_046416746.1	2	Reactome: R-HSA-3214841;Reactome: R-HSA-8936459	"PKMTs methylate histone lysines";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"
XP_046412447.1	24	Reactome: R-HSA-2132295;Reactome: R-HSA-5617833;Reactome: R-HSA-190861;Reactome: R-HSA-9646399;Reactome: R-HSA-6811436;Reactome: R-HSA-8852276;Reactome: R-HSA-68877;Reactome: R-HSA-190840;Reactome: R-HSA-9609736;Reactome: R-HSA-8955332;Reactome: R-HSA-437239;Reactome: R-HSA-5663220;Reactome: R-HSA-3371497;Reactome: R-HSA-6811434;Reactome: R-HSA-2467813;Reactome: R-HSA-9609690;Reactome: R-HSA-380320;Reactome: R-HSA-9648025;Reactome: R-HSA-2500257;Reactome: R-HSA-983189;Reactome: R-HSA-1445148;Reactome: R-HSA-9619483;Reactome: R-HSA-6807878;Reactome: R-HSA-5626467	"MHC class II antigen presentation";"Cilium Assembly";"Gap junction assembly";"Aggrephagy";"COPI-independent Golgi-to-ER retrograde traffic";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Mitotic Prometaphase";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Assembly and cell surface presentation of NMDA receptors";"Carboxyterminal post-translational modifications of tubulin";"Recycling pathway of L1";"RHO GTPases Activate Formins";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-dependent Golgi-to-ER retrograde traffic";"Separation of Sister Chromatids";"HCMV Early Events";"Recruitment of NuMA to mitotic centrosomes";"EML4 and NUDC in mitotic spindle formation";"Resolution of Sister Chromatid Cohesion";"Kinesins";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Activation of AMPK downstream of NMDARs";"COPI-mediated anterograde transport";"RHO GTPases activate IQGAPs"
XP_046431959.1	12	MetaCyc: PWY-6932;KEGG: 00920+2.7.7.4;Reactome: R-HSA-174362;MetaCyc: PWY-6683;MetaCyc: PWY-5278;KEGG: 00261+2.7.7.4;KEGG: 00230+2.7.7.4;MetaCyc: PWY-5340;KEGG: 00230+2.7.1.25;Reactome: R-HSA-2408550;KEGG: 00450+2.7.7.4;KEGG: 00920+2.7.1.25	"Selenate reduction";"Sulfur metabolism";"Transport and synthesis of PAPS";"Assimilatory sulfate reduction III";"Sulfite oxidation III";"Monobactam biosynthesis";"Purine metabolism";"Sulfate activation for sulfonation";"Purine metabolism";"Metabolism of ingested H2SeO4 and H2SeO3 into H2Se";"Selenocompound metabolism";"Sulfur metabolism"
XP_046413486.1	4	KEGG: 00562+1.13.99.1;MetaCyc: PWY-4841;KEGG: 00053+1.13.99.1;Reactome: R-HSA-1855183	"Inositol phosphate metabolism";"UDP-alpha-D-glucuronate biosynthesis (from myo-inositol)";"Ascorbate and aldarate metabolism";"Synthesis of IP2, IP, and Ins in the cytosol"
XP_046430163.1	12	MetaCyc: PWY-6708;MetaCyc: PWY-5855;MetaCyc: PWY-5857;MetaCyc: PWY-5856;MetaCyc: PWY-5870;KEGG: 00130+2.5.1.39;Reactome: R-HSA-1268020;MetaCyc: PWY-5872;Reactome: R-HSA-2142789;MetaCyc: PWY-5873;MetaCyc: PWY-5871;MetaCyc: PWY-6978	"Ubiquinol-8 biosynthesis (prokaryotic)";"Ubiquinol-7 biosynthesis (prokaryotic)";"Ubiquinol-10 biosynthesis (prokaryotic)";"Ubiquinol-9 biosynthesis (prokaryotic)";"Ubiquinol-8 biosynthesis (eukaryotic)";"Ubiquinone and other terpenoid-quinone biosynthesis";"Mitochondrial protein import";"Ubiquinol-10 biosynthesis (eukaryotic)";"Ubiquinol biosynthesis";"Ubiquinol-7 biosynthesis (eukaryotic)";"Ubiquinol-9 biosynthesis (eukaryotic)";"Plastoquinol-9 biosynthesis II"
XP_046418330.1	3	Reactome: R-HSA-193648;Reactome: R-HSA-416482;Reactome: R-HSA-194840	"NRAGE signals death through JNK";"G alpha (12/13) signalling events";"Rho GTPase cycle"
XP_046419933.1	8	Reactome: R-HSA-5083633;KEGG: 00515+2.4.1.109;MetaCyc: PWY-7979;KEGG: 00514+2.4.1.109;MetaCyc: PWY-7921;Reactome: R-HSA-5173105;Reactome: R-HSA-5083629;MetaCyc: PWY-7922	"Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1";"Mannose type O-glycan biosynthesis";"Protein O-mannosylation III (mammals, core M3)";"Other types of O-glycan biosynthesis";"Protein O-mannosylation I (yeast)";"O-linked glycosylation";"Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2";"Protein O-mannosylation II (mammals, core M1 and core M2)"
XP_046422572.1	4	Reactome: R-HSA-5693579;Reactome: R-HSA-5693554;Reactome: R-HSA-5685942;Reactome: R-HSA-5693568	"Homologous DNA Pairing and Strand Exchange";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"HDR through Homologous Recombination (HRR)";"Resolution of D-loop Structures through Holliday Junction Intermediates"
XP_046418582.1	5	Reactome: R-HSA-1222556;Reactome: R-HSA-77387;Reactome: R-HSA-917977;Reactome: R-HSA-9639288;Reactome: R-HSA-983712	"ROS and RNS production in phagocytes";"Insulin receptor recycling";"Transferrin endocytosis and recycling";"Amino acids regulate mTORC1";"Ion channel transport"
XP_046419683.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_046427917.1	6	MetaCyc: PWY-7817;KEGG: 00561+2.7.1.107;MetaCyc: PWY-7039;KEGG: 04070+2.7.1.107;KEGG: 00564+2.7.1.107;Reactome: R-HSA-114508	"Type I lipoteichoic acid biosynthesis (S. aureus)";"Glycerolipid metabolism";"Phosphatidate metabolism, as a signaling molecule";"Phosphatidylinositol signaling system";"Glycerophospholipid metabolism";"Effects of PIP2 hydrolysis"
XP_046435531.1	2	Reactome: R-HSA-400253;Reactome: R-HSA-2151201	"Circadian Clock";"Transcriptional activation of mitochondrial biogenesis"
XP_046427252.1	8	MetaCyc: PWY-7181;KEGG: 00983+3.5.4.5;KEGG: 00240+3.5.4.5;MetaCyc: PWY-6556;Reactome: R-HSA-73614;MetaCyc: PWY-7199;Reactome: R-HSA-6798695;MetaCyc: PWY-7193	"Pyrimidine deoxyribonucleosides degradation";"Drug metabolism - other enzymes";"Pyrimidine metabolism";"Pyrimidine ribonucleosides salvage II";"Pyrimidine salvage";"Pyrimidine deoxyribonucleosides salvage";"Neutrophil degranulation";"Pyrimidine ribonucleosides salvage I"
XP_046435375.1	2	Reactome: R-HSA-8856828;Reactome: R-HSA-8856825	"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis"
XP_046426721.1	3	Reactome: R-HSA-3359471;KEGG: 00860+2.5.1.17;Reactome: R-HSA-196741	"Defective MMAB causes methylmalonic aciduria type cblB";"Porphyrin and chlorophyll metabolism";"Cobalamin (Cbl, vitamin B12) transport and metabolism"
XP_046421640.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046428851.1	6	Reactome: R-HSA-5545483;Reactome: R-HSA-5358606;Reactome: R-HSA-5358565;Reactome: R-HSA-912446;Reactome: R-HSA-6796648;Reactome: R-HSA-5632987	"Defective Mismatch Repair Associated With MLH1";"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"Meiotic recombination";"TP53 Regulates Transcription of DNA Repair Genes";"Defective Mismatch Repair Associated With PMS2"
XP_046418472.1	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
XP_046431986.1	3	Reactome: R-HSA-2206296;Reactome: R-HSA-2024096;Reactome: R-HSA-2024101	"MPS II - Hunter syndrome";"HS-GAG degradation";"CS/DS degradation"
XP_046414790.1	16	Reactome: R-HSA-177504;Reactome: R-HSA-2132295;Reactome: R-HSA-8856828;Reactome: R-HSA-8964038;Reactome: R-HSA-437239;Reactome: R-HSA-8856825;Reactome: R-HSA-8866427;Reactome: R-HSA-167590;Reactome: R-HSA-182218;Reactome: R-HSA-3928665;Reactome: R-HSA-416993;Reactome: R-HSA-5140745;Reactome: R-HSA-5099900;Reactome: R-HSA-190873;Reactome: R-HSA-164939;Reactome: R-HSA-196025	"Retrograde neurotrophin signalling";"MHC class II antigen presentation";"Clathrin-mediated endocytosis";"LDL clearance";"Recycling pathway of L1";"Cargo recognition for clathrin-mediated endocytosis";"VLDLR internalisation and degradation";"Nef Mediated CD4 Down-regulation";"Nef Mediated CD8 Down-regulation";"EPH-ephrin mediated repulsion of cells";"Trafficking of GluR2-containing AMPA receptors";"WNT5A-dependent internalization of FZD2, FZD5 and ROR2";"WNT5A-dependent internalization of FZD4";"Gap junction degradation";"Nef mediated downregulation of CD28 cell surface expression";"Formation of annular gap junctions"
XP_046433517.1	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
XP_046422224.1	1	Reactome: R-HSA-6802952	"Signaling by BRAF and RAF fusions"
XP_046419997.1	19	Reactome: R-HSA-9620244;Reactome: R-HSA-6802946;Reactome: R-HSA-5673000;Reactome: R-HSA-5673001;Reactome: R-HSA-6802955;Reactome: R-HSA-6802952;Reactome: R-HSA-9649948;Reactome: R-HSA-3371571;Reactome: R-HSA-442982;Reactome: R-HSA-9617324;Reactome: R-HSA-877300;Reactome: R-HSA-5576892;Reactome: R-HSA-111932;Reactome: R-HSA-9022692;Reactome: R-HSA-438066;Reactome: R-HSA-5578775;Reactome: R-HSA-399719;Reactome: R-HSA-936837;Reactome: R-HSA-9609736	"Long-term potentiation";"Signaling by moderate kinase activity BRAF mutants";"RAF activation";"RAF/MAP kinase cascade";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"Signaling by BRAF and RAF fusions";"Signaling downstream of RAS mutants";"HSF1-dependent transactivation";"Ras activation upon Ca2+ influx through NMDA receptor";"Negative regulation of NMDA receptor-mediated neuronal transmission";"Interferon gamma signaling";"Phase 0 - rapid depolarisation";"CaMK IV-mediated phosphorylation of CREB";"Regulation of MECP2 expression and activity";"Unblocking of NMDA receptors, glutamate binding and activation";"Ion homeostasis";"Trafficking of AMPA receptors";"Ion transport by P-type ATPases";"Assembly and cell surface presentation of NMDA receptors"
XP_046434404.1	3	Reactome: R-HSA-110331;Reactome: R-HSA-110357;Reactome: R-HSA-110330	"Cleavage of the damaged purine";"Displacement of DNA glycosylase by APEX1";"Recognition and association of DNA glycosylase with site containing an affected purine"
XP_046429297.1	1	Reactome: R-HSA-400253	"Circadian Clock"
XP_046432146.1	3	KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16	"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
XP_046427158.1	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
XP_046431134.1	2	Reactome: R-HSA-445355;Reactome: R-HSA-390522	"Smooth Muscle Contraction";"Striated Muscle Contraction"
XP_046419460.1	1	Reactome: R-HSA-2559584	"Formation of Senescence-Associated Heterochromatin Foci (SAHF)"
XP_046432499.1	1	Reactome: R-HSA-8876725	"Protein methylation"
XP_046415190.1	4	MetaCyc: PWY-6803;KEGG: 00592+3.1.1.32;MetaCyc: PWY-8051;KEGG: 00564+3.1.1.32	"Phosphatidylcholine acyl editing";"alpha-Linolenic acid metabolism";"Anandamide biosynthesis I";"Glycerophospholipid metabolism"
XP_046416968.1	26	Reactome: R-HSA-3371497;Reactome: R-HSA-437239;Reactome: R-HSA-389977;Reactome: R-HSA-5663220;Reactome: R-HSA-9609736;Reactome: R-HSA-8955332;Reactome: R-HSA-6811436;Reactome: R-HSA-9646399;Reactome: R-HSA-190861;Reactome: R-HSA-190840;Reactome: R-HSA-68877;Reactome: R-HSA-8852276;Reactome: R-HSA-5617833;Reactome: R-HSA-2132295;Reactome: R-HSA-5626467;Reactome: R-HSA-6807878;Reactome: R-HSA-9619483;Reactome: R-HSA-389960;Reactome: R-HSA-2500257;Reactome: R-HSA-983189;Reactome: R-HSA-1445148;Reactome: R-HSA-380320;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813;Reactome: R-HSA-9609690;Reactome: R-HSA-6811434	"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Recycling pathway of L1";"Post-chaperonin tubulin folding pathway";"RHO GTPases Activate Formins";"Assembly and cell surface presentation of NMDA receptors";"Carboxyterminal post-translational modifications of tubulin";"COPI-independent Golgi-to-ER retrograde traffic";"Aggrephagy";"Gap junction assembly";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Mitotic Prometaphase";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Cilium Assembly";"MHC class II antigen presentation";"RHO GTPases activate IQGAPs";"COPI-mediated anterograde transport";"Activation of AMPK downstream of NMDARs";"Formation of tubulin folding intermediates by CCT/TriC";"Resolution of Sister Chromatid Cohesion";"Kinesins";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Recruitment of NuMA to mitotic centrosomes";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids";"HCMV Early Events";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_046424837.1	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
XP_046433401.1	9	MetaCyc: PWY-5664;KEGG: 00790+3.5.4.16;MetaCyc: PWY-6147;MetaCyc: PWY-7442;Reactome: R-HSA-1474151;MetaCyc: PWY-6703;MetaCyc: PWY-5663;MetaCyc: PWY-6983;MetaCyc: PWY-7852	"Erythro-tetrahydrobiopterin biosynthesis II";"Folate biosynthesis";"6-hydroxymethyl-dihydropterin diphosphate biosynthesis I";"Drosopterin and aurodrosopterin biosynthesis";"Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation";"Preq0 biosynthesis";"Erythro-tetrahydrobiopterin biosynthesis I";"Threo-tetrahydrobiopterin biosynthesis";"6-hydroxymethyl-dihydropterin diphosphate biosynthesis IV (Plasmodium)"
XP_046413081.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046429499.1	5	KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16;Reactome: R-HSA-5687128;Reactome: R-HSA-176407;KEGG: 05235+3.1.3.16	"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation";"MAPK6/MAPK4 signaling";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
XP_046419783.1	1	Reactome: R-HSA-390522	"Striated Muscle Contraction"
XP_046436301.1	7	Reactome: R-HSA-5620912;Reactome: R-HSA-380284;Reactome: R-HSA-380320;Reactome: R-HSA-2565942;Reactome: R-HSA-380270;Reactome: R-HSA-8854518;Reactome: R-HSA-380259	"Anchoring of the basal body to the plasma membrane";"Loss of proteins required for interphase microtubule organization from the centrosome";"Recruitment of NuMA to mitotic centrosomes";"Regulation of PLK1 Activity at G2/M Transition";"Recruitment of mitotic centrosome proteins and complexes";"AURKA Activation by TPX2";"Loss of Nlp from mitotic centrosomes"
XP_046422104.1	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
XP_046410108.1	1	Reactome: R-HSA-2151201	"Transcriptional activation of mitochondrial biogenesis"
XP_046415671.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_046409416.1	2	Reactome: R-HSA-416476;Reactome: R-HSA-375276	"G alpha (q) signalling events";"Peptide ligand-binding receptors"
XP_046420717.1	14	MetaCyc: PWY-7724;Reactome: R-HSA-75876;MetaCyc: PWY-5972;MetaCyc: PWY-6433;MetaCyc: PWY-7035;MetaCyc: PWY-8041;MetaCyc: PWY-6598;MetaCyc: PWY-7036;MetaCyc: PWY-7602;MetaCyc: PWY-5080;MetaCyc: PWY-7601;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7619;MetaCyc: PWY-7725	"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Synthesis of very long-chain fatty acyl-CoAs";"Stearate biosynthesis I (animals)";"Hydroxylated fatty acid biosynthesis (plants)";"(9Z)-tricosene biosynthesis";"Ultra-long-chain fatty acid biosynthesis";"Sciadonate biosynthesis";"Very long chain fatty acid biosynthesis II";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis I";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Fatty acid elongation";"Juniperonate biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)"
XP_046435857.1	2	Reactome: R-HSA-429947;Reactome: R-HSA-6804115	"Deadenylation of mRNA";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"
XP_046418041.1	8	Reactome: R-HSA-68949;Reactome: R-HSA-68962;Reactome: R-HSA-176187;Reactome: R-HSA-68827;Reactome: R-HSA-113507;Reactome: R-HSA-68689;Reactome: R-HSA-68616;Reactome: R-HSA-68867	"Orc1 removal from chromatin";"Activation of the pre-replicative complex";"Activation of ATR in response to replication stress";"CDT1 association with the CDC6:ORC:origin complex";"E2F-enabled inhibition of pre-replication complex formation";"CDC6 association with the ORC:origin complex";"Assembly of the ORC complex at the origin of replication";"Assembly of the pre-replicative complex"
XP_046429533.1	2	Reactome: R-HSA-8876198;Reactome: R-HSA-5357905	"RAB GEFs exchange GTP for GDP on RABs";"Regulation of TNFR1 signaling"
XP_046428095.1	2	Reactome: R-HSA-5628897;Reactome: R-HSA-611105	"TP53 Regulates Metabolic Genes";"Respiratory electron transport"
XP_046419177.1	2	Reactome: R-HSA-390471;Reactome: R-HSA-1660662	"Association of TriC/CCT with target proteins during biosynthesis";"Glycosphingolipid metabolism"
XP_046429449.1	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
XP_046428460.1	6	Reactome: R-HSA-8963889;Reactome: R-HSA-8957275;Reactome: R-HSA-381426;Reactome: R-HSA-8874211;Reactome: R-HSA-1655829;Reactome: R-HSA-381033	"Assembly of active LPL and LIPC lipase complexes";"Post-translational protein phosphorylation";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"CREB3 factors activate genes";"Regulation of cholesterol biosynthesis by SREBP (SREBF)";"ATF6 (ATF6-alpha) activates chaperones"
XP_046425596.1	1	Reactome: R-HSA-6811434	"COPI-dependent Golgi-to-ER retrograde traffic"
XP_046431715.1	1	Reactome: R-HSA-6809371	"Formation of the cornified envelope"
XP_046426021.1	2	KEGG: 00561+2.7.1.30;MetaCyc: PWY-4261	"Glycerolipid metabolism";"Glycerol degradation I"
XP_046435915.1	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
XP_046420652.1	2	Reactome: R-HSA-429947;Reactome: R-HSA-6804115	"Deadenylation of mRNA";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"
XP_046413223.1	1	Reactome: R-HSA-70221	"Glycogen breakdown (glycogenolysis)"
XP_046434738.1	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286	"Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation"
XP_046413863.1	2	Reactome: R-HSA-5625740;KEGG: 04070+2.7.11.13	"RHO GTPases activate PKNs";"Phosphatidylinositol signaling system"
XP_046428635.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_046434102.1	2	Reactome: R-HSA-203927;Reactome: R-HSA-426486	"MicroRNA (miRNA) biogenesis";"Small interfering RNA (siRNA) biogenesis"
XP_046418258.1	1	Reactome: R-HSA-110357	"Displacement of DNA glycosylase by APEX1"
XP_046432200.1	4	Reactome: R-HSA-445095;Reactome: R-HSA-6807878;Reactome: R-HSA-375165;Reactome: R-HSA-5673001	"Interaction between L1 and Ankyrins";"COPI-mediated anterograde transport";"NCAM signaling for neurite out-growth";"RAF/MAP kinase cascade"
XP_046434499.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046414502.1	1	Reactome: R-HSA-9609523	"Insertion of tail-anchored proteins into the endoplasmic reticulum membrane"
XP_046424554.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046424022.1	8	KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;Reactome: R-HSA-428540;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1	"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Relaxin signaling pathway";"Human cytomegalovirus infection";"Activation of RAC1";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Thermogenesis"
XP_046421980.1	2	Reactome: R-HSA-418457;Reactome: R-HSA-1296052	"cGMP effects";"Ca2+ activated K+ channels"
XP_046418828.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046430531.1	14	MetaCyc: PWY-6433;MetaCyc: PWY-7724;Reactome: R-HSA-75876;MetaCyc: PWY-5972;MetaCyc: PWY-7619;MetaCyc: PWY-7725;MetaCyc: PWY-5080;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7601;MetaCyc: PWY-8041;MetaCyc: PWY-6598;MetaCyc: PWY-7036;MetaCyc: PWY-7602;MetaCyc: PWY-7035	"Hydroxylated fatty acid biosynthesis (plants)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Synthesis of very long-chain fatty acyl-CoAs";"Stearate biosynthesis I (animals)";"Juniperonate biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Very long chain fatty acid biosynthesis I";"Fatty acid elongation";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Ultra-long-chain fatty acid biosynthesis";"Sciadonate biosynthesis";"Very long chain fatty acid biosynthesis II";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"(9Z)-tricosene biosynthesis"
XP_046410715.1	2	Reactome: R-HSA-1236394;Reactome: R-HSA-977443	"Signaling by ERBB4";"GABA receptor activation"
XP_046431786.1	3	Reactome: R-HSA-8856828;Reactome: R-HSA-8875656;Reactome: R-HSA-8854214	"Clathrin-mediated endocytosis";"MET receptor recycling";"TBC/RABGAPs"
XP_046425435.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046432126.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_046436575.1	1	Reactome: R-HSA-432047	"Passive transport by Aquaporins"
XP_046429810.1	1	Reactome: R-HSA-6806664	"Metabolism of vitamin K"
XP_046432733.1	7	Reactome: R-HSA-380284;Reactome: R-HSA-5620912;Reactome: R-HSA-380270;Reactome: R-HSA-2565942;Reactome: R-HSA-380320;Reactome: R-HSA-380259;Reactome: R-HSA-8854518	"Loss of proteins required for interphase microtubule organization from the centrosome";"Anchoring of the basal body to the plasma membrane";"Recruitment of mitotic centrosome proteins and complexes";"Regulation of PLK1 Activity at G2/M Transition";"Recruitment of NuMA to mitotic centrosomes";"Loss of Nlp from mitotic centrosomes";"AURKA Activation by TPX2"
XP_046428807.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_046431426.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046427286.1	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
XP_046422399.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046410281.1	2	Reactome: R-HSA-6804115;Reactome: R-HSA-429947	"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Deadenylation of mRNA"
XP_046420867.1	33	Reactome: R-HSA-9610379;Reactome: R-HSA-9648025;Reactome: R-HSA-3108214;Reactome: R-HSA-159231;Reactome: R-HSA-1169408;Reactome: R-HSA-2467813;Reactome: R-HSA-3232142;Reactome: R-HSA-2500257;Reactome: R-HSA-3371453;Reactome: R-HSA-4551638;Reactome: R-HSA-5619107;Reactome: R-HSA-168276;Reactome: R-HSA-191859;Reactome: R-HSA-159230;Reactome: R-HSA-4615885;Reactome: R-HSA-168271;Reactome: R-HSA-4570464;Reactome: R-HSA-141444;Reactome: R-HSA-159236;Reactome: R-HSA-168325;Reactome: R-HSA-9609690;Reactome: R-HSA-170822;Reactome: R-HSA-180910;Reactome: R-HSA-165054;Reactome: R-HSA-6784531;Reactome: R-HSA-4085377;Reactome: R-HSA-3301854;Reactome: R-HSA-180746;Reactome: R-HSA-5578749;Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-168333;Reactome: R-HSA-159227	"HCMV Late Events";"EML4 and NUDC in mitotic spindle formation";"SUMOylation of DNA damage response and repair proteins";"Transport of Mature mRNA Derived from an Intronless Transcript";"ISG15 antiviral mechanism";"Separation of Sister Chromatids";"SUMOylation of ubiquitinylation proteins";"Resolution of Sister Chromatid Cohesion";"Regulation of HSF1-mediated heat shock response";"SUMOylation of chromatin organization proteins";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"NS1 Mediated Effects on Host Pathways";"snRNP Assembly";"Transport of the SLBP Dependant Mature mRNA";"SUMOylation of DNA replication proteins";"Transport of Ribonucleoproteins into the Host Nucleus";"SUMOylation of RNA binding proteins";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Viral Messenger RNA Synthesis";"HCMV Early Events";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Vpr-mediated nuclear import of PICs";"Rev-mediated nuclear export of HIV RNA";"tRNA processing in the nucleus";"SUMOylation of SUMOylation proteins";"Nuclear Pore Complex (NPC) Disassembly";"Nuclear import of Rev protein";"Transcriptional regulation by small RNAs";"Mitotic Prometaphase";"RHO GTPases Activate Formins";"NEP/NS2 Interacts with the Cellular Export Machinery";"Transport of the SLBP independent Mature mRNA"
XP_046429520.1	1	Reactome: R-HSA-419771	"Opsins"
XP_046411445.1	1	Reactome: R-HSA-8949664	"Processing of SMDT1"
XP_046427696.1	7	Reactome: R-HSA-2467813;Reactome: R-HSA-68877;Reactome: R-HSA-141444;Reactome: R-HSA-606279;Reactome: R-HSA-9648025;Reactome: R-HSA-2500257;Reactome: R-HSA-5663220	"Separation of Sister Chromatids";"Mitotic Prometaphase";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Deposition of new CENPA-containing nucleosomes at the centromere";"EML4 and NUDC in mitotic spindle formation";"Resolution of Sister Chromatid Cohesion";"RHO GTPases Activate Formins"
XP_046417009.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046423265.1	17	MetaCyc: PWY-4381;MetaCyc: PWY-5789;KEGG: 00061+6.4.1.2;Reactome: R-HSA-3371599;KEGG: 00640+6.4.1.2;Reactome: R-HSA-200425;MetaCyc: PWY-5966-1;Reactome: R-HSA-196780;MetaCyc: PWY-6679;Reactome: R-HSA-2426168;MetaCyc: PWY-5743;KEGG: 00720+6.4.1.2;KEGG: 00620+6.4.1.2;Reactome: R-HSA-163765;MetaCyc: PWY-5744;KEGG: 00254+6.4.1.2;MetaCyc: PWY-6722	"Fatty acid biosynthesis initiation (bacteria and plants)";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Fatty acid biosynthesis";"Defective HLCS causes multiple carboxylase deficiency";"Propanoate metabolism";"Carnitine metabolism";"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)";"Biotin transport and metabolism";"Jadomycin biosynthesis";"Activation of gene expression by SREBF (SREBP)";"3-hydroxypropanoate cycle";"Carbon fixation pathways in prokaryotes";"Pyruvate metabolism";"ChREBP activates metabolic gene expression";"Glyoxylate assimilation";"Aflatoxin biosynthesis";"Candicidin biosynthesis"
XP_046426745.1	3	MetaCyc: PWY-7511;Reactome: R-HSA-349425;Reactome: R-HSA-8951664	"Protein ubiquitination";"Autodegradation of the E3 ubiquitin ligase COP1";"Neddylation"
XP_046420447.1	7	Reactome: R-HSA-2894862;Reactome: R-HSA-2122948;Reactome: R-HSA-2644606;Reactome: R-HSA-9013507;Reactome: R-HSA-2979096;Reactome: R-HSA-2660826;Reactome: R-HSA-2691232	"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Activated NOTCH1 Transmits Signal to the Nucleus";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant";"Constitutive Signaling by NOTCH1 HD Domain Mutants"
XP_046435448.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046421355.1	1	Reactome: R-HSA-9037629	"Lewis blood group biosynthesis"
XP_046414393.1	2	KEGG: 00051+2.7.1.105+3.1.3.46;Reactome: R-HSA-9634600	"Fructose and mannose metabolism";"Regulation of glycolysis by fructose 2,6-bisphosphate metabolism"
XP_046413304.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046414591.1	1	Reactome: R-HSA-1660661	"Sphingolipid de novo biosynthesis"
XP_046436074.1	6	KEGG: 00564+2.7.1.107;Reactome: R-HSA-114508;KEGG: 04070+2.7.1.107;KEGG: 00561+2.7.1.107;MetaCyc: PWY-7039;MetaCyc: PWY-7817	"Glycerophospholipid metabolism";"Effects of PIP2 hydrolysis";"Phosphatidylinositol signaling system";"Glycerolipid metabolism";"Phosphatidate metabolism, as a signaling molecule";"Type I lipoteichoic acid biosynthesis (S. aureus)"
XP_046410954.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_046417711.1	3	KEGG: 00230+3.6.1.17;Reactome: R-HSA-3299685;KEGG: 00240+3.6.1.17	"Purine metabolism";"Detoxification of Reactive Oxygen Species";"Pyrimidine metabolism"
XP_046436612.1	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
XP_046419251.1	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
XP_046429639.1	29	Reactome: R-HSA-76042;Reactome: R-HSA-75955;Reactome: R-HSA-167172;Reactome: R-HSA-73863;Reactome: R-HSA-112382;Reactome: R-HSA-73776;Reactome: R-HSA-674695;Reactome: R-HSA-72086;Reactome: R-HSA-77075;Reactome: R-HSA-6796648;Reactome: R-HSA-167200;Reactome: R-HSA-73772;Reactome: R-HSA-5696395;Reactome: R-HSA-167161;Reactome: R-HSA-167152;Reactome: R-HSA-75953;Reactome: R-HSA-427413;Reactome: R-HSA-167162;Reactome: R-HSA-167246;Reactome: R-HSA-6781823;Reactome: R-HSA-113418;Reactome: R-HSA-6782210;Reactome: R-HSA-167158;Reactome: R-HSA-5696400;Reactome: R-HSA-6781827;Reactome: R-HSA-6782135;Reactome: R-HSA-73779;Reactome: R-HSA-167160;Reactome: R-HSA-73762	"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II Transcription Elongation";"Transcription of the HIV genome";"RNA Polymerase I Transcription Termination";"Formation of RNA Pol II elongation complex";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Pre-transcription Events";"mRNA Capping";"RNA Pol II CTD phosphorylation and interaction with CE";"TP53 Regulates Transcription of DNA Repair Genes";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Polymerase I Promoter Escape";"Formation of Incision Complex in GG-NER";"HIV Transcription Initiation";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Polymerase II Transcription Initiation";"NoRC negatively regulates rRNA expression";"RNA Polymerase II HIV Promoter Escape";"Tat-mediated elongation of the HIV-1 transcript";"Formation of TC-NER Pre-Incision Complex";"Formation of the Early Elongation Complex";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Formation of the HIV-1 Early Elongation Complex";"Dual Incision in GG-NER";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Dual incision in TC-NER";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"RNA Polymerase I Transcription Initiation"
XP_046412636.1	5	Reactome: R-HSA-5694530;Reactome: R-HSA-983170;Reactome: R-HSA-1655829;Reactome: R-HSA-204005;Reactome: R-HSA-2132295	"Cargo concentration in the ER";"Antigen Presentation: Folding, assembly and peptide loading of class I MHC";"Regulation of cholesterol biosynthesis by SREBP (SREBF)";"COPII-mediated vesicle transport";"MHC class II antigen presentation"
XP_046410556.1	2	Reactome: R-HSA-3108214;MetaCyc: PWY-7511	"SUMOylation of DNA damage response and repair proteins";"Protein ubiquitination"
XP_046426216.1	2	Reactome: R-HSA-6791226;Reactome: R-HSA-390471	"Major pathway of rRNA processing in the nucleolus and cytosol";"Association of TriC/CCT with target proteins during biosynthesis"
XP_046426737.1	8	Reactome: R-HSA-380972;Reactome: R-HSA-165159;Reactome: R-HSA-1632852;Reactome: R-HSA-166208;Reactome: R-HSA-5628897;Reactome: R-HSA-9639288;Reactome: R-HSA-8943724;Reactome: R-HSA-3371571	"Energy dependent regulation of mTOR by LKB1-AMPK";"mTOR signalling";"Macroautophagy";"mTORC1-mediated signalling";"TP53 Regulates Metabolic Genes";"Amino acids regulate mTORC1";"Regulation of PTEN gene transcription";"HSF1-dependent transactivation"
XP_046413555.1	12	Reactome: R-HSA-5663220;Reactome: R-HSA-2500257;Reactome: R-HSA-3371497;Reactome: R-HSA-6807878;Reactome: R-HSA-2132295;Reactome: R-HSA-9648025;Reactome: R-HSA-141444;Reactome: R-HSA-68877;Reactome: R-HSA-9609690;Reactome: R-HSA-2467813;Reactome: R-HSA-9646399;Reactome: R-HSA-6811436	"RHO GTPases Activate Formins";"Resolution of Sister Chromatid Cohesion";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-mediated anterograde transport";"MHC class II antigen presentation";"EML4 and NUDC in mitotic spindle formation";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Mitotic Prometaphase";"HCMV Early Events";"Separation of Sister Chromatids";"Aggrephagy";"COPI-independent Golgi-to-ER retrograde traffic"
XP_046412474.1	4	Reactome: R-HSA-5656121;Reactome: R-HSA-5656169;Reactome: R-HSA-5655862;Reactome: R-HSA-110312	"Translesion synthesis by POLI";"Termination of translesion DNA synthesis";"Translesion synthesis by POLK";"Translesion synthesis by REV1"
XP_046415701.1	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046432248.1	2	Reactome: R-HSA-8951664;Reactome: R-HSA-983168	"Neddylation";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046428299.1	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
XP_046419800.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046422215.1	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
XP_046434278.1	4	Reactome: R-HSA-6798163;KEGG: 00260+1.2.1.8+1.1.99.1;MetaCyc: PWY-7494;MetaCyc: PWY-3722	"Choline catabolism";"Glycine, serine and threonine metabolism";"Choline degradation IV";"Glycine betaine biosynthesis II (Gram-positive bacteria)"
XP_046411110.1	15	Reactome: R-HSA-5693568;Reactome: R-HSA-2559586;Reactome: R-HSA-5693579;Reactome: R-HSA-5693565;Reactome: R-HSA-5685942;Reactome: R-HSA-5693548;Reactome: R-HSA-5693607;Reactome: R-HSA-912446;Reactome: R-HSA-5693571;Reactome: R-HSA-6804756;Reactome: R-HSA-69473;Reactome: R-HSA-5685939;Reactome: R-HSA-5685938;Reactome: R-HSA-5693554;Reactome: R-HSA-5693616	"Resolution of D-loop Structures through Holliday Junction Intermediates";"DNA Damage/Telomere Stress Induced Senescence";"Homologous DNA Pairing and Strand Exchange";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"HDR through Homologous Recombination (HRR)";"Sensing of DNA Double Strand Breaks";"Processing of DNA double-strand break ends";"Meiotic recombination";"Nonhomologous End-Joining (NHEJ)";"Regulation of TP53 Activity through Phosphorylation";"G2/M DNA damage checkpoint";"HDR through MMEJ (alt-NHEJ)";"HDR through Single Strand Annealing (SSA)";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Presynaptic phase of homologous DNA pairing and strand exchange"
XP_046434986.1	4	Reactome: R-HSA-3214815;Reactome: R-HSA-8943724;Reactome: R-HSA-73762;Reactome: R-HSA-427389	"HDACs deacetylate histones";"Regulation of PTEN gene transcription";"RNA Polymerase I Transcription Initiation";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression"
XP_046421654.1	2	Reactome: R-HSA-373752;Reactome: R-HSA-525793	"Netrin-1 signaling";"Myogenesis"
XP_046425733.1	1	Reactome: R-HSA-1660662	"Glycosphingolipid metabolism"
XP_046426295.1	2	Reactome: R-HSA-73980;Reactome: R-HSA-749476	"RNA Polymerase III Transcription Termination";"RNA Polymerase III Abortive And Retractive Initiation"
XP_046435011.1	2	Reactome: R-HSA-2151201;Reactome: R-HSA-163282	"Transcriptional activation of mitochondrial biogenesis";"Mitochondrial transcription initiation"
XP_046411638.1	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
XP_046413113.1	2	Reactome: R-HSA-379716;KEGG: 00970+6.1.1.7	"Cytosolic tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis"
XP_046414963.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_046433355.1	1	Reactome: R-HSA-216083	"Integrin cell surface interactions"
XP_046436633.1	2	Reactome: R-HSA-418457;Reactome: R-HSA-4086398	"cGMP effects";"Ca2+ pathway"
XP_046430267.1	9	KEGG: 00562+3.1.4.11;MetaCyc: PWY-7039;MetaCyc: PWY-6351;MetaCyc: PWY-8052;Reactome: R-HSA-112043;MetaCyc: PWY-6367;KEGG: 04070+3.1.4.11;Reactome: R-HSA-1855204;Reactome: R-HSA-416476	"Inositol phosphate metabolism";"Phosphatidate metabolism, as a signaling molecule";"D-myo-inositol (1,4,5)-trisphosphate biosynthesis";"2-arachidonoylglycerol biosynthesis";"PLC beta mediated events";"D-myo-inositol-5-phosphate metabolism";"Phosphatidylinositol signaling system";"Synthesis of IP3 and IP4 in the cytosol";"G alpha (q) signalling events"
XP_046427576.1	1	Reactome: R-HSA-5620922	"BBSome-mediated cargo-targeting to cilium"
XP_046410731.1	4	Reactome: R-HSA-5576892;Reactome: R-HSA-419037;Reactome: R-HSA-5576893;Reactome: R-HSA-112308	"Phase 0 - rapid depolarisation";"NCAM1 interactions";"Phase 2 - plateau phase";"Presynaptic depolarization and calcium channel opening"
XP_046435149.1	7	Reactome: R-HSA-8854518;Reactome: R-HSA-380259;Reactome: R-HSA-380320;Reactome: R-HSA-380270;Reactome: R-HSA-2565942;Reactome: R-HSA-380284;Reactome: R-HSA-5620912	"AURKA Activation by TPX2";"Loss of Nlp from mitotic centrosomes";"Recruitment of NuMA to mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes";"Regulation of PLK1 Activity at G2/M Transition";"Loss of proteins required for interphase microtubule organization from the centrosome";"Anchoring of the basal body to the plasma membrane"
XP_046429827.1	8	KEGG: 00052+2.7.1.1;KEGG: 00500+2.7.1.1;KEGG: 00520+2.7.1.1;KEGG: 00010+2.7.1.1;KEGG: 00051+2.7.1.1;Reactome: R-HSA-70171;KEGG: 00521+2.7.1.1;KEGG: 00524+2.7.1.1	"Galactose metabolism";"Starch and sucrose metabolism";"Amino sugar and nucleotide sugar metabolism";"Glycolysis / Gluconeogenesis";"Fructose and mannose metabolism";"Glycolysis";"Streptomycin biosynthesis";"Neomycin, kanamycin and gentamicin biosynthesis"
XP_046412507.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_046412125.1	2	Reactome: R-HSA-9033241;Reactome: R-HSA-389661	"Peroxisomal protein import";"Glyoxylate metabolism and glycine degradation"
XP_046423348.1	2	KEGG: 00230+3.1.4.53;Reactome: R-HSA-180024	"Purine metabolism";"DARPP-32 events"
XP_046428490.1	6	Reactome: R-HSA-381033;Reactome: R-HSA-381426;Reactome: R-HSA-8957275;Reactome: R-HSA-8963889;Reactome: R-HSA-8874211;Reactome: R-HSA-1655829	"ATF6 (ATF6-alpha) activates chaperones";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"Post-translational protein phosphorylation";"Assembly of active LPL and LIPC lipase complexes";"CREB3 factors activate genes";"Regulation of cholesterol biosynthesis by SREBP (SREBF)"
XP_046436224.1	3	Reactome: R-HSA-1445148;Reactome: R-HSA-5620916;Reactome: R-HSA-264876	"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"VxPx cargo-targeting to cilium";"Insulin processing"
XP_046434186.1	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286	"Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation"
XP_046435367.1	2	Reactome: R-HSA-8856825;Reactome: R-HSA-8856828	"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis"
XP_046425819.1	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
XP_046436622.1	1	Reactome: R-HSA-2428928	"IRS-related events triggered by IGF1R"
XP_046420375.1	3	Reactome: R-HSA-4420097;Reactome: R-HSA-5663213;Reactome: R-HSA-2029482	"VEGFA-VEGFR2 Pathway";"RHO GTPases Activate WASPs and WAVEs";"Regulation of actin dynamics for phagocytic cup formation"
XP_046433837.1	1	Reactome: R-HSA-1474228	"Degradation of the extracellular matrix"
XP_046430194.1	2	Reactome: R-HSA-2682334;Reactome: R-HSA-3928665	"EPH-Ephrin signaling";"EPH-ephrin mediated repulsion of cells"
XP_046415970.1	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
XP_046434429.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_046422717.1	2	Reactome: R-HSA-1663150;Reactome: R-HSA-1660662	"The activation of arylsulfatases";"Glycosphingolipid metabolism"
XP_046434175.1	52	Reactome: R-HSA-167162;Reactome: R-HSA-6807505;Reactome: R-HSA-6781823;Reactome: R-HSA-203927;Reactome: R-HSA-113418;Reactome: R-HSA-6782210;Reactome: R-HSA-167287;Reactome: R-HSA-167158;Reactome: R-HSA-6781827;Reactome: R-HSA-5578749;Reactome: R-HSA-73762;Reactome: R-HSA-75955;Reactome: R-HSA-5617472;Reactome: R-HSA-76042;Reactome: R-HSA-72203;Reactome: R-HSA-72163;Reactome: R-HSA-167243;Reactome: R-HSA-112382;Reactome: R-HSA-73780;Reactome: R-HSA-73776;Reactome: R-HSA-72086;Reactome: R-HSA-9018519;Reactome: R-HSA-8851708;Reactome: R-HSA-167161;Reactome: R-HSA-168325;Reactome: R-HSA-72165;Reactome: R-HSA-167246;Reactome: R-HSA-76066;Reactome: R-HSA-427413;Reactome: R-HSA-75953;Reactome: R-HSA-167238;Reactome: R-HSA-73980;Reactome: R-HSA-6782135;Reactome: R-HSA-73779;Reactome: R-HSA-167160;Reactome: R-HSA-5250924;Reactome: R-HSA-167172;Reactome: R-HSA-76071;Reactome: R-HSA-73863;Reactome: R-HSA-5601884;Reactome: R-HSA-77075;Reactome: R-HSA-167200;Reactome: R-HSA-6796648;Reactome: R-HSA-76061;Reactome: R-HSA-167242;Reactome: R-HSA-674695;Reactome: R-HSA-1834949;Reactome: R-HSA-167152;Reactome: R-HSA-6803529;Reactome: R-HSA-749476;Reactome: R-HSA-167290;Reactome: R-HSA-73772	"RNA Polymerase II HIV Promoter Escape";"RNA polymerase II transcribes snRNA genes";"Formation of TC-NER Pre-Incision Complex";"MicroRNA (miRNA) biogenesis";"Formation of the Early Elongation Complex";"Gap-filling DNA repair synthesis and ligation in TC-NER";"HIV elongation arrest and recovery";"Formation of the HIV-1 Early Elongation Complex";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Transcriptional regulation by small RNAs";"RNA Polymerase I Transcription Initiation";"RNA Polymerase II Transcription Elongation";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Processing of Capped Intron-Containing Pre-mRNA";"mRNA Splicing - Major Pathway";"Tat-mediated HIV elongation arrest and recovery";"Formation of RNA Pol II elongation complex";"RNA Polymerase III Chain Elongation";"RNA Polymerase II Promoter Escape";"mRNA Capping";"Estrogen-dependent gene expression";"Signaling by FGFR2 IIIa TM";"HIV Transcription Initiation";"Viral Messenger RNA Synthesis";"mRNA Splicing - Minor Pathway";"Tat-mediated elongation of the HIV-1 transcript";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"NoRC negatively regulates rRNA expression";"RNA Polymerase II Transcription Initiation";"Pausing and recovery of Tat-mediated HIV elongation";"RNA Polymerase III Transcription Termination";"Dual incision in TC-NER";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"B-WICH complex positively regulates rRNA expression";"Transcription of the HIV genome";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase I Transcription Termination";"PIWI-interacting RNA (piRNA) biogenesis";"RNA Pol II CTD phosphorylation and interaction with CE";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"Abortive elongation of HIV-1 transcript in the absence of Tat";"RNA Polymerase II Pre-transcription Events";"Cytosolic sensors of pathogen-associated DNA";"Formation of HIV elongation complex in the absence of HIV Tat";"FGFR2 alternative splicing";"RNA Polymerase III Abortive And Retractive Initiation";"Pausing and recovery of HIV elongation";"RNA Polymerase I Promoter Escape"
XP_046436504.1	8	KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04151+2.7.11.1;Reactome: R-HSA-2028269;KEGG: 04150+2.7.11.1	"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Thermogenesis";"Relaxin signaling pathway";"Human cytomegalovirus infection";"PI3K-Akt signaling pathway";"Signaling by Hippo";"mTOR signaling pathway"
XP_046429690.1	3	Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-212436	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"Generic Transcription Pathway"
XP_046424814.1	13	Reactome: R-HSA-4086398;Reactome: R-HSA-112043;Reactome: R-HSA-5578775;Reactome: R-HSA-422356;Reactome: R-HSA-2029485;Reactome: R-HSA-1489509;Reactome: R-HSA-2871809;Reactome: R-HSA-5607763;Reactome: R-HSA-139853;Reactome: R-HSA-114508;Reactome: R-HSA-5218921;Reactome: R-HSA-983695;Reactome: R-HSA-381676	"Ca2+ pathway";"PLC beta mediated events";"Ion homeostasis";"Regulation of insulin secretion";"Role of phospholipids in phagocytosis";"DAG and IP3 signaling";"FCERI mediated Ca+2 mobilization";"CLEC7A (Dectin-1) induces NFAT activation";"Elevation of cytosolic Ca2+ levels";"Effects of PIP2 hydrolysis";"VEGFR2 mediated cell proliferation";"Antigen activates B Cell Receptor (BCR) leading to generation of second messengers";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion"
XP_046436338.1	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
XP_046416458.1	31	Reactome: R-HSA-2426168;MetaCyc: PWY-8012;MetaCyc: PWYG-321;MetaCyc: PWY-8049;Reactome: R-HSA-199220;KEGG: 00780+1.1.1.100+4.2.1.59+2.3.1.41;MetaCyc: PWY-5367;MetaCyc: PWY-5142;MetaCyc: PWY-7664;MetaCyc: PWY-5966-1;MetaCyc: PWY-7388;MetaCyc: PWY-4381;MetaCyc: PWY-6799;MetaCyc: PWY-5994;MetaCyc: PWY-6113;MetaCyc: PWY-7663;MetaCyc: PWY-6519;MetaCyc: PWY-5971;Reactome: R-HSA-163765;MetaCyc: PWY-5366;KEGG: 00061+1.1.1.100+2.3.1.85+4.2.1.59+2.3.1.39+2.3.1.41+3.1.2.14;MetaCyc: PWY-8047;MetaCyc: PWY-5973;MetaCyc: PWY-6282;Reactome: R-HSA-75105;MetaCyc: PWY-7858;Reactome: R-HSA-9029558;MetaCyc: PWY-5147;MetaCyc: PWY-7746;MetaCyc: PWY-5989;MetaCyc: PWY-7723	"Activation of gene expression by SREBF (SREBP)";"Mupirocin biosynthesis";"";"Pederin biosynthesis";"Vitamin B5 (pantothenate) metabolism";"Biotin metabolism";"Petroselinate biosynthesis";"Acyl-[acyl-carrier protein] thioesterase pathway";"Oleate biosynthesis IV (anaerobic)";"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)";"Octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast)";"Fatty acid biosynthesis initiation (bacteria and plants)";"Fatty acid biosynthesis initiation (plant mitochondria)";"Palmitate biosynthesis (animals and fungi, cytoplasm)";"Superpathway of mycolate biosynthesis";"Gondoate biosynthesis (anaerobic)";"8-amino-7-oxononanoate biosynthesis I";"Palmitate biosynthesis II (bacteria and plant cytoplasm)";"ChREBP activates metabolic gene expression";"Palmitoleate biosynthesis II (plants and bacteria)";"Fatty acid biosynthesis";"Bryostatin biosynthesis";"Cis-vaccenate biosynthesis";"Palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate)";"Fatty acyl-CoA biosynthesis";"(5Z)-dodecenoate biosynthesis II";"NR1H2 & NR1H3 regulate gene expression linked to lipogenesis";"Oleate biosynthesis I (plants)";"Mycobacterial sulfolipid biosynthesis";"Stearate biosynthesis II (bacteria and plants)";"Bacterial bioluminescence"
XP_046434380.1	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
XP_046424272.1	1	Reactome: R-HSA-77108	"Utilization of Ketone Bodies"
XP_046411085.1	3	Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-9018519	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"Estrogen-dependent gene expression"
XP_046433131.1	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
XP_046409737.1	9	Reactome: R-HSA-6804756;Reactome: R-HSA-167161;Reactome: R-HSA-674695;Reactome: R-HSA-73776;Reactome: R-HSA-73779;Reactome: R-HSA-75953;Reactome: R-HSA-76042;Reactome: R-HSA-167172;Reactome: R-HSA-167162	"Regulation of TP53 Activity through Phosphorylation";"HIV Transcription Initiation";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Transcription of the HIV genome";"RNA Polymerase II HIV Promoter Escape"
XP_046430832.1	1	Reactome: R-HSA-977443	"GABA receptor activation"
XP_046417395.1	5	Reactome: R-HSA-174490;Reactome: R-HSA-917729;Reactome: R-HSA-162588;Reactome: R-HSA-9610379;Reactome: R-HSA-9615710	"Membrane binding and targetting of GAG proteins";"Endosomal Sorting Complex Required For Transport (ESCRT)";"Budding and maturation of HIV virion";"HCMV Late Events";"Late endosomal microautophagy"
XP_046416577.1	3	KEGG: 00970+2.1.2.9;KEGG: 00670+2.1.2.9;Reactome: R-HSA-5368286	"Aminoacyl-tRNA biosynthesis";"One carbon pool by folate";"Mitochondrial translation initiation"
XP_046436678.1	12	Reactome: R-HSA-2132295;Reactome: R-HSA-141444;Reactome: R-HSA-9648025;Reactome: R-HSA-6811436;Reactome: R-HSA-2467813;Reactome: R-HSA-9646399;Reactome: R-HSA-9609690;Reactome: R-HSA-68877;Reactome: R-HSA-2500257;Reactome: R-HSA-5663220;Reactome: R-HSA-3371497;Reactome: R-HSA-6807878	"MHC class II antigen presentation";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"EML4 and NUDC in mitotic spindle formation";"COPI-independent Golgi-to-ER retrograde traffic";"Separation of Sister Chromatids";"Aggrephagy";"HCMV Early Events";"Mitotic Prometaphase";"Resolution of Sister Chromatid Cohesion";"RHO GTPases Activate Formins";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-mediated anterograde transport"
XP_046411260.1	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046418880.1	1	Reactome: R-HSA-212436	"Generic Transcription Pathway"
XP_046418365.1	1	Reactome: R-HSA-6790901	"rRNA modification in the nucleus and cytosol"
XP_046427437.1	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_046411854.1	5	Reactome: R-HSA-1482883;KEGG: 00561+2.3.1.20;Reactome: R-HSA-6798695;Reactome: R-HSA-75109;KEGG: 00073+2.3.1.20	"Acyl chain remodeling of DAG and TAG";"Glycerolipid metabolism";"Neutrophil degranulation";"Triglyceride biosynthesis";"Cutin, suberine and wax biosynthesis"
XP_046415268.1	8	KEGG: 00230+2.7.4.8;Reactome: R-HSA-9620244;Reactome: R-HSA-5673001;Reactome: R-HSA-9617324;Reactome: R-HSA-438066;MetaCyc: PWY-7221;Reactome: R-HSA-442982;Reactome: R-HSA-9609736	"Purine metabolism";"Long-term potentiation";"RAF/MAP kinase cascade";"Negative regulation of NMDA receptor-mediated neuronal transmission";"Unblocking of NMDA receptors, glutamate binding and activation";"Guanosine ribonucleotides de novo biosynthesis";"Ras activation upon Ca2+ influx through NMDA receptor";"Assembly and cell surface presentation of NMDA receptors"
XP_046419331.1	4	Reactome: R-HSA-8856825;Reactome: R-HSA-5250958;Reactome: R-HSA-8856828;Reactome: R-HSA-6794361	"Cargo recognition for clathrin-mediated endocytosis";"Toxicity of botulinum toxin type B (BoNT/B)";"Clathrin-mediated endocytosis";"Neurexins and neuroligins"
XP_046424842.1	2	Reactome: R-HSA-6798695;Reactome: R-HSA-532668	"Neutrophil degranulation";"N-glycan trimming in the ER and Calnexin/Calreticulin cycle"
XP_046418583.1	2	Reactome: R-HSA-380270;Reactome: R-HSA-380320	"Recruitment of mitotic centrosome proteins and complexes";"Recruitment of NuMA to mitotic centrosomes"
XP_046426896.1	2	Reactome: R-HSA-1268020;Reactome: R-HSA-1482798	"Mitochondrial protein import";"Acyl chain remodeling of CL"
XP_046429202.1	16	Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-2408557;Reactome: R-HSA-72706;Reactome: R-HSA-6791226;Reactome: R-HSA-72702;Reactome: R-HSA-975956;Reactome: R-HSA-72689;Reactome: R-HSA-192823;Reactome: R-HSA-72695;Reactome: R-HSA-1799339;Reactome: R-HSA-975957;Reactome: R-HSA-156902;Reactome: R-HSA-72764;Reactome: R-HSA-72649	"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Selenocysteine synthesis";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Major pathway of rRNA processing in the nucleolus and cytosol";"Ribosomal scanning and start codon recognition";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Formation of a pool of free 40S subunits";"Viral mRNA Translation";"Formation of the ternary complex, and subsequently, the 43S complex";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Peptide chain elongation";"Eukaryotic Translation Termination";"Translation initiation complex formation"
XP_046432414.1	15	Reactome: R-HSA-70171;MetaCyc: PWY-7003;KEGG: 00620+2.7.1.40;KEGG: 00230+2.7.1.40;MetaCyc: PWY-5484;MetaCyc: PWY-1042;MetaCyc: PWY-7383;MetaCyc: PWY-6142;MetaCyc: PWY-5723;KEGG: 00010+2.7.1.40;MetaCyc: PWY-8004;MetaCyc: PWY-2221;MetaCyc: PWY-6901;MetaCyc: PWY-6886;MetaCyc: PWY-7218	"Glycolysis";"Glycerol degradation to butanol";"Pyruvate metabolism";"Purine metabolism";"Glycolysis II (from fructose 6-phosphate)";"Glycolysis IV (plant cytosol)";"Anaerobic energy metabolism (invertebrates, cytosol)";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Rubisco shunt";"Glycolysis / Gluconeogenesis";"Entner-Doudoroff pathway I";"Entner-Doudoroff pathway III (semi-phosphorylative)";"Superpathway of glucose and xylose degradation";"1-butanol autotrophic biosynthesis (engineered)";"Photosynthetic 3-hydroxybutanoate biosynthesis (engineered)"
XP_046415223.1	2	MetaCyc: PWY-7221;KEGG: 00230+2.7.4.8	"Guanosine ribonucleotides de novo biosynthesis";"Purine metabolism"
XP_046420316.1	7	MetaCyc: PWY-5461;MetaCyc: PWY-6824;MetaCyc: PWY-7445;MetaCyc: PWY-7214;KEGG: 00940+1.11.1.7;MetaCyc: PWY-5466;MetaCyc: PWY-5469	"Betanidin degradation";"Justicidin B biosynthesis";"Luteolin triglucuronide degradation";"Baicalein degradation (hydrogen peroxide detoxification)";"Phenylpropanoid biosynthesis";"Matairesinol biosynthesis";"Sesamin biosynthesis"
XP_046418229.1	1	Reactome: R-HSA-2468052	"Establishment of Sister Chromatid Cohesion"
XP_046435100.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046430205.1	2	Reactome: R-HSA-2682334;Reactome: R-HSA-3928665	"EPH-Ephrin signaling";"EPH-ephrin mediated repulsion of cells"
XP_046418442.1	1	Reactome: R-HSA-3238698	"WNT ligand biogenesis and trafficking"
XP_046426480.1	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
XP_046425288.1	17	KEGG: 04150+2.7.11.1;Reactome: R-HSA-6796648;Reactome: R-HSA-176187;KEGG: 04151+2.7.11.1;Reactome: R-HSA-5693616;Reactome: R-HSA-6804756;Reactome: R-HSA-69473;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;Reactome: R-HSA-3371453;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;Reactome: R-HSA-5685938;Reactome: R-HSA-1221632;Reactome: R-HSA-6783310;Reactome: R-HSA-5693607;KEGG: 05165+2.7.11.1	"mTOR signaling pathway";"TP53 Regulates Transcription of DNA Repair Genes";"Activation of ATR in response to replication stress";"PI3K-Akt signaling pathway";"Presynaptic phase of homologous DNA pairing and strand exchange";"Regulation of TP53 Activity through Phosphorylation";"G2/M DNA damage checkpoint";"Relaxin signaling pathway";"Human cytomegalovirus infection";"Regulation of HSF1-mediated heat shock response";"Human immunodeficiency virus 1 infection";"Thermogenesis";"HDR through Single Strand Annealing (SSA)";"Meiotic synapsis";"Fanconi Anemia Pathway";"Processing of DNA double-strand break ends";"Human papillomavirus infection"
XP_046421588.1	5	MetaCyc: PWY-5046;KEGG: 00280+1.2.4.4;KEGG: 00640+1.2.4.4;Reactome: R-HSA-389661;Reactome: R-HSA-70895	"2-oxoisovalerate decarboxylation to isobutanoyl-CoA";"Valine, leucine and isoleucine degradation";"Propanoate metabolism";"Glyoxylate metabolism and glycine degradation";"Branched-chain amino acid catabolism"
XP_046423218.1	1	KEGG: 04660+2.7.10.2	"T cell receptor signaling pathway"
XP_046435363.1	6	KEGG: 00790+4.2.3.12;MetaCyc: PWY-7442;MetaCyc: PWY-6983;MetaCyc: PWY-5663;Reactome: R-HSA-1474151;MetaCyc: PWY-5664	"Folate biosynthesis";"Drosopterin and aurodrosopterin biosynthesis";"Threo-tetrahydrobiopterin biosynthesis";"Erythro-tetrahydrobiopterin biosynthesis I";"Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation";"Erythro-tetrahydrobiopterin biosynthesis II"
XP_046429534.1	2	Reactome: R-HSA-5357905;Reactome: R-HSA-8876198	"Regulation of TNFR1 signaling";"RAB GEFs exchange GTP for GDP on RABs"
XP_046409693.1	1	Reactome: R-HSA-163125	"Post-translational modification: synthesis of GPI-anchored proteins"
XP_046429588.1	7	KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1	"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Relaxin signaling pathway";"Thermogenesis";"Human cytomegalovirus infection";"mTOR signaling pathway";"PI3K-Akt signaling pathway"
XP_046428221.1	2	Reactome: R-HSA-429947;Reactome: R-HSA-6804115	"Deadenylation of mRNA";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"
XP_046414795.1	1	Reactome: R-HSA-9609523	"Insertion of tail-anchored proteins into the endoplasmic reticulum membrane"
XP_046419518.1	3	Reactome: R-HSA-3000157;Reactome: R-HSA-3000171;Reactome: R-HSA-8874081	"Laminin interactions";"Non-integrin membrane-ECM interactions";"MET activates PTK2 signaling"
XP_046413341.1	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276	"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination"
XP_046426009.1	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046432738.1	7	Reactome: R-HSA-2565942;Reactome: R-HSA-380270;Reactome: R-HSA-380320;Reactome: R-HSA-380259;Reactome: R-HSA-8854518;Reactome: R-HSA-380284;Reactome: R-HSA-5620912	"Regulation of PLK1 Activity at G2/M Transition";"Recruitment of mitotic centrosome proteins and complexes";"Recruitment of NuMA to mitotic centrosomes";"Loss of Nlp from mitotic centrosomes";"AURKA Activation by TPX2";"Loss of proteins required for interphase microtubule organization from the centrosome";"Anchoring of the basal body to the plasma membrane"
XP_046425358.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_046418479.1	1	Reactome: R-HSA-8854214	"TBC/RABGAPs"
XP_046432800.1	3	MetaCyc: PWY-7511;Reactome: R-HSA-349425;Reactome: R-HSA-8951664	"Protein ubiquitination";"Autodegradation of the E3 ubiquitin ligase COP1";"Neddylation"
XP_046414629.1	9	Reactome: R-HSA-6782135;Reactome: R-HSA-5696400;Reactome: R-HSA-6781827;Reactome: R-HSA-5696395;Reactome: R-HSA-8951664;Reactome: R-HSA-6781823;Reactome: R-HSA-110314;Reactome: R-HSA-6782210;Reactome: R-HSA-5696394	"Dual incision in TC-NER";"Dual Incision in GG-NER";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Formation of Incision Complex in GG-NER";"Neddylation";"Formation of TC-NER Pre-Incision Complex";"Recognition of DNA damage by PCNA-containing replication complex";"Gap-filling DNA repair synthesis and ligation in TC-NER";"DNA Damage Recognition in GG-NER"
XP_046430409.1	27	Reactome: R-HSA-4551638;Reactome: R-HSA-4085377;Reactome: R-HSA-6784531;Reactome: R-HSA-165054;Reactome: R-HSA-3371453;Reactome: R-HSA-180910;Reactome: R-HSA-170822;Reactome: R-HSA-3232142;Reactome: R-HSA-9609690;Reactome: R-HSA-3108214;Reactome: R-HSA-168325;Reactome: R-HSA-1169408;Reactome: R-HSA-159231;Reactome: R-HSA-159236;Reactome: R-HSA-4570464;Reactome: R-HSA-9610379;Reactome: R-HSA-168333;Reactome: R-HSA-159227;Reactome: R-HSA-168271;Reactome: R-HSA-4615885;Reactome: R-HSA-159230;Reactome: R-HSA-180746;Reactome: R-HSA-5578749;Reactome: R-HSA-191859;Reactome: R-HSA-168276;Reactome: R-HSA-3301854;Reactome: R-HSA-5619107	"SUMOylation of chromatin organization proteins";"SUMOylation of SUMOylation proteins";"tRNA processing in the nucleus";"Rev-mediated nuclear export of HIV RNA";"Regulation of HSF1-mediated heat shock response";"Vpr-mediated nuclear import of PICs";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"SUMOylation of ubiquitinylation proteins";"HCMV Early Events";"SUMOylation of DNA damage response and repair proteins";"Viral Messenger RNA Synthesis";"ISG15 antiviral mechanism";"Transport of Mature mRNA Derived from an Intronless Transcript";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"SUMOylation of RNA binding proteins";"HCMV Late Events";"NEP/NS2 Interacts with the Cellular Export Machinery";"Transport of the SLBP independent Mature mRNA";"Transport of Ribonucleoproteins into the Host Nucleus";"SUMOylation of DNA replication proteins";"Transport of the SLBP Dependant Mature mRNA";"Nuclear import of Rev protein";"Transcriptional regulation by small RNAs";"snRNP Assembly";"NS1 Mediated Effects on Host Pathways";"Nuclear Pore Complex (NPC) Disassembly";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)"
XP_046414746.1	1	Reactome: R-HSA-425986	"Sodium/Proton exchangers"
XP_046416916.1	14	MetaCyc: PWY-7416;MetaCyc: PWY-8053;MetaCyc: PWY-7409;MetaCyc: PWY-7417;KEGG: 00591+3.1.1.4;Reactome: R-HSA-1482788;MetaCyc: PWY-6803;KEGG: 00565+3.1.1.4;KEGG: 00564+3.1.1.4+3.1.1.5;MetaCyc: PWY-8051;MetaCyc: PWY-7783;KEGG: 00592+3.1.1.4;Reactome: R-HSA-975634;KEGG: 00590+3.1.1.4	"Phospholipid remodeling (phosphatidylcholine, yeast)";"Anandamide biosynthesis II";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Phospholipid remodeling (phosphatidate, yeast)";"Linoleic acid metabolism";"Acyl chain remodelling of PC";"Phosphatidylcholine acyl editing";"Ether lipid metabolism";"Glycerophospholipid metabolism";"Anandamide biosynthesis I";"Plasmalogen degradation";"alpha-Linolenic acid metabolism";"Retinoid metabolism and transport";"Arachidonic acid metabolism"
XP_046420076.1	7	KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1	"Thermogenesis";"Human cytomegalovirus infection";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Relaxin signaling pathway";"mTOR signaling pathway";"PI3K-Akt signaling pathway"
XP_046417808.1	5	Reactome: R-HSA-8939243;Reactome: R-HSA-201722;Reactome: R-HSA-1266695;Reactome: R-HSA-3214858;Reactome: R-HSA-3247509	"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"Formation of the beta-catenin:TCF transactivating complex";"Interleukin-7 signaling";"RMTs methylate histone arginines";"Chromatin modifying enzymes"
XP_046419686.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_046429933.1	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
XP_046415402.1	1	Reactome: R-HSA-114608	"Platelet degranulation"
XP_046412905.1	15	Reactome: R-HSA-167290;Reactome: R-HSA-167152;Reactome: R-HSA-674695;Reactome: R-HSA-167242;Reactome: R-HSA-167158;Reactome: R-HSA-167287;Reactome: R-HSA-6796648;Reactome: R-HSA-167200;Reactome: R-HSA-113418;Reactome: R-HSA-112382;Reactome: R-HSA-167238;Reactome: R-HSA-167243;Reactome: R-HSA-9603505;Reactome: R-HSA-167246;Reactome: R-HSA-75955	"Pausing and recovery of HIV elongation";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Polymerase II Pre-transcription Events";"Abortive elongation of HIV-1 transcript in the absence of Tat";"Formation of the HIV-1 Early Elongation Complex";"HIV elongation arrest and recovery";"TP53 Regulates Transcription of DNA Repair Genes";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Formation of the Early Elongation Complex";"Formation of RNA Pol II elongation complex";"Pausing and recovery of Tat-mediated HIV elongation";"Tat-mediated HIV elongation arrest and recovery";"NTRK3 as a dependence receptor";"Tat-mediated elongation of the HIV-1 transcript";"RNA Polymerase II Transcription Elongation"
XP_046434319.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_046426794.1	4	KEGG: 00230+2.7.4.3;Reactome: R-HSA-499943;KEGG: 00730+2.7.4.3;MetaCyc: PWY-7219	"Purine metabolism";"Interconversion of nucleotide di- and triphosphates";"Thiamine metabolism";"Adenosine ribonucleotides de novo biosynthesis"
XP_046425183.1	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
XP_046430778.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_046424330.1	14	MetaCyc: PWY-6433;MetaCyc: PWY-7724;MetaCyc: PWY-5972;Reactome: R-HSA-75876;MetaCyc: PWY-7619;MetaCyc: PWY-7725;MetaCyc: PWY-5080;MetaCyc: PWY-7601;KEGG: 00062+2.3.1.199;MetaCyc: PWY-8041;MetaCyc: PWY-6598;MetaCyc: PWY-7036;MetaCyc: PWY-7602;MetaCyc: PWY-7035	"Hydroxylated fatty acid biosynthesis (plants)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Stearate biosynthesis I (animals)";"Synthesis of very long-chain fatty acyl-CoAs";"Juniperonate biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Very long chain fatty acid biosynthesis I";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Fatty acid elongation";"Ultra-long-chain fatty acid biosynthesis";"Sciadonate biosynthesis";"Very long chain fatty acid biosynthesis II";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"(9Z)-tricosene biosynthesis"
XP_046429056.1	1	Reactome: R-HSA-1632852	"Macroautophagy"
XP_046427004.1	1	Reactome: R-HSA-5689880	"Ub-specific processing proteases"
XP_046423592.1	6	MetaCyc: PWY-6362;Reactome: R-HSA-1855183;MetaCyc: PWY-6364;KEGG: 04070+3.1.3.56;MetaCyc: PWY-6363;KEGG: 00562+3.1.3.56	"1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)";"Synthesis of IP2, IP, and Ins in the cytosol";"D-myo-inositol (1,3,4)-trisphosphate biosynthesis";"Phosphatidylinositol signaling system";"D-myo-inositol (1,4,5)-trisphosphate degradation";"Inositol phosphate metabolism"
XP_046422245.1	1	Reactome: R-HSA-6784531	"tRNA processing in the nucleus"
XP_046433533.1	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
XP_046414335.1	6	Reactome: R-HSA-68962;Reactome: R-HSA-68949;Reactome: R-HSA-69052;Reactome: R-HSA-176974;Reactome: R-HSA-68867;Reactome: R-HSA-176187	"Activation of the pre-replicative complex";"Orc1 removal from chromatin";"Switching of origins to a post-replicative state";"Unwinding of DNA";"Assembly of the pre-replicative complex";"Activation of ATR in response to replication stress"
XP_046432388.1	1	Reactome: R-HSA-70350	"Fructose catabolism"
XP_046429423.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046431427.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046422274.1	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
XP_046427722.1	3	Reactome: R-HSA-6784531;MetaCyc: PWY-6689;MetaCyc: PWY-7803	"tRNA processing in the nucleus";"Trna splicing I";"Trna splicing II"
XP_046423400.1	34	Reactome: R-HSA-168271;Reactome: R-HSA-168276;Reactome: R-HSA-5619107;Reactome: R-HSA-4615885;Reactome: R-HSA-159230;Reactome: R-HSA-191859;Reactome: R-HSA-3371453;Reactome: R-HSA-2500257;Reactome: R-HSA-3232142;Reactome: R-HSA-4551638;Reactome: R-HSA-9610379;Reactome: R-HSA-3108214;Reactome: R-HSA-1169408;Reactome: R-HSA-2467813;Reactome: R-HSA-159231;Reactome: R-HSA-9648025;Reactome: R-HSA-5663220;Reactome: R-HSA-168333;Reactome: R-HSA-159227;Reactome: R-HSA-3301854;Reactome: R-HSA-68877;Reactome: R-HSA-5578749;Reactome: R-HSA-180746;Reactome: R-HSA-180910;Reactome: R-HSA-170822;Reactome: R-HSA-4085377;Reactome: R-HSA-165054;Reactome: R-HSA-6784531;Reactome: R-HSA-9639288;Reactome: R-HSA-4570464;Reactome: R-HSA-9609690;Reactome: R-HSA-168325;Reactome: R-HSA-141444;Reactome: R-HSA-159236	"Transport of Ribonucleoproteins into the Host Nucleus";"NS1 Mediated Effects on Host Pathways";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"SUMOylation of DNA replication proteins";"Transport of the SLBP Dependant Mature mRNA";"snRNP Assembly";"Regulation of HSF1-mediated heat shock response";"Resolution of Sister Chromatid Cohesion";"SUMOylation of ubiquitinylation proteins";"SUMOylation of chromatin organization proteins";"HCMV Late Events";"SUMOylation of DNA damage response and repair proteins";"ISG15 antiviral mechanism";"Separation of Sister Chromatids";"Transport of Mature mRNA Derived from an Intronless Transcript";"EML4 and NUDC in mitotic spindle formation";"RHO GTPases Activate Formins";"NEP/NS2 Interacts with the Cellular Export Machinery";"Transport of the SLBP independent Mature mRNA";"Nuclear Pore Complex (NPC) Disassembly";"Mitotic Prometaphase";"Transcriptional regulation by small RNAs";"Nuclear import of Rev protein";"Vpr-mediated nuclear import of PICs";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"SUMOylation of SUMOylation proteins";"Rev-mediated nuclear export of HIV RNA";"tRNA processing in the nucleus";"Amino acids regulate mTORC1";"SUMOylation of RNA binding proteins";"HCMV Early Events";"Viral Messenger RNA Synthesis";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Transport of Mature mRNA derived from an Intron-Containing Transcript"
XP_046435260.1	3	KEGG: 00740+3.1.3.2;MetaCyc: PWY-6348;KEGG: 00730+3.1.3.2	"Riboflavin metabolism";"Phosphate acquisition";"Thiamine metabolism"
XP_046409733.1	5	Reactome: R-HSA-159236;Reactome: R-HSA-72187;Reactome: R-HSA-72163;Reactome: R-HSA-73856;Reactome: R-HSA-72165	"Transport of Mature mRNA derived from an Intron-Containing Transcript";"mRNA 3'-end processing";"mRNA Splicing - Major Pathway";"RNA Polymerase II Transcription Termination";"mRNA Splicing - Minor Pathway"
XP_046419637.1	1	Reactome: R-HSA-211897	"Cytochrome P450 - arranged by substrate type"
XP_046415091.1	2	Reactome: R-HSA-3214858;Reactome: R-HSA-8939243	"RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"
XP_046430736.1	3	Reactome: R-HSA-1445148;Reactome: R-HSA-5620916;Reactome: R-HSA-264876	"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"VxPx cargo-targeting to cilium";"Insulin processing"
XP_046430924.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_046429803.1	2	Reactome: R-HSA-445355;Reactome: R-HSA-390522	"Smooth Muscle Contraction";"Striated Muscle Contraction"
XP_046418287.1	1	Reactome: R-HSA-418886	"Netrin mediated repulsion signals"
XP_046411537.1	7	KEGG: 00562+3.1.3.25;Reactome: R-HSA-1855183;KEGG: 04070+3.1.3.25;MetaCyc: PWY-4702;MetaCyc: PWY-2301;KEGG: 00521+3.1.3.25;MetaCyc: PWY-6363	"Inositol phosphate metabolism";"Synthesis of IP2, IP, and Ins in the cytosol";"Phosphatidylinositol signaling system";"Phytate degradation I";"Myo-inositol biosynthesis";"Streptomycin biosynthesis";"D-myo-inositol (1,4,5)-trisphosphate degradation"
XP_046422470.1	2	Reactome: R-HSA-388479;Reactome: R-HSA-416476	"Vasopressin-like receptors";"G alpha (q) signalling events"
XP_046416939.1	56	Reactome: R-HSA-8854050;Reactome: R-HSA-9020702;Reactome: R-HSA-174113;Reactome: R-HSA-5687128;Reactome: R-HSA-68827;Reactome: R-HSA-5689603;Reactome: R-HSA-180534;Reactome: R-HSA-187577;Reactome: R-HSA-5607764;Reactome: R-HSA-69481;Reactome: R-HSA-1234176;Reactome: R-HSA-8948751;Reactome: R-HSA-5610783;Reactome: R-HSA-8852276;Reactome: R-HSA-450408;Reactome: R-HSA-5610780;Reactome: R-HSA-1236974;Reactome: R-HSA-211733;Reactome: R-HSA-4641258;Reactome: R-HSA-5632684;Reactome: R-HSA-8941858;Reactome: R-HSA-9010553;Reactome: R-HSA-350562;Reactome: R-HSA-5668541;Reactome: R-HSA-5362768;Reactome: R-HSA-5676590;Reactome: R-HSA-9604323;Reactome: R-HSA-69017;Reactome: R-HSA-5358346;Reactome: R-HSA-69601;Reactome: R-HSA-382556;Reactome: R-HSA-68949;Reactome: R-HSA-1169091;Reactome: R-HSA-195253;Reactome: R-HSA-174178;Reactome: R-HSA-2871837;Reactome: R-HSA-8951664;Reactome: R-HSA-5689880;Reactome: R-HSA-174084;Reactome: R-HSA-349425;Reactome: R-HSA-1236978;Reactome: R-HSA-202424;Reactome: R-HSA-75815;Reactome: R-HSA-4641257;Reactome: R-HSA-4608870;Reactome: R-HSA-5678895;Reactome: R-HSA-180585;Reactome: R-HSA-5610785;Reactome: R-HSA-8939236;Reactome: R-HSA-5607761;Reactome: R-HSA-983168;Reactome: R-HSA-5658442;Reactome: R-HSA-174154;Reactome: R-HSA-8939902;Reactome: R-HSA-174184;Reactome: R-HSA-2467813	"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Interleukin-1 signaling";"SCF-beta-TrCP mediated degradation of Emi1";"MAPK6/MAPK4 signaling";"CDT1 association with the CDC6:ORC:origin complex";"UCH proteinases";"Vpu mediated degradation of CD4";"SCF(Skp2)-mediated degradation of p27/p21";"CLEC7A (Dectin-1) signaling";"G2/M Checkpoints";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of PTEN stability and activity";"Degradation of GLI2 by the proteasome";"The role of GTSE1 in G2/M progression after G2 checkpoint";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Degradation of GLI1 by the proteasome";"ER-Phagosome pathway";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Degradation of DVL";"Hedgehog 'on' state";"Regulation of RUNX3 expression and activity";"Regulation of expression of SLITs and ROBOs";"Regulation of ornithine decarboxylase (ODC)";"TNFR2 non-canonical NF-kB pathway";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"NIK-->noncanonical NF-kB signaling";"Negative regulation of NOTCH4 signaling";"CDK-mediated phosphorylation and removal of Cdc6";"Hedgehog ligand biogenesis";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"ABC-family proteins mediated transport";"Orc1 removal from chromatin";"Activation of NF-kappaB in B cells";"Degradation of beta-catenin by the destruction complex";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"FCERI mediated NF-kB activation";"Neddylation";"Ub-specific processing proteases";"Autodegradation of Cdh1 by Cdh1:APC/C";"Autodegradation of the E3 ubiquitin ligase COP1";"Cross-presentation of soluble exogenous antigens (endosomes)";"Downstream TCR signaling";"Ubiquitin-dependent degradation of Cyclin D";"Degradation of AXIN";"Asymmetric localization of PCP proteins";"Defective CFTR causes cystic fibrosis";"Vif-mediated degradation of APOBEC3G";"GLI3 is processed to GLI3R by the proteasome";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Dectin-1 mediated noncanonical NF-kB signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Regulation of RAS by GAPs";"APC/C:Cdc20 mediated degradation of Securin";"Regulation of RUNX2 expression and activity";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Separation of Sister Chromatids"
XP_046424288.1	2	Reactome: R-HSA-2142700;Reactome: R-HSA-2142691	"Synthesis of Lipoxins (LX)";"Synthesis of Leukotrienes (LT) and Eoxins (EX)"
XP_046420169.1	1	Reactome: R-HSA-5662702	"Melanin biosynthesis"
XP_046427110.1	1	Reactome: R-HSA-8964038	"LDL clearance"
XP_046426201.1	2	Reactome: R-HSA-2514853;Reactome: R-HSA-2299718	"Condensation of Prometaphase Chromosomes";"Condensation of Prophase Chromosomes"
XP_046411761.1	4	Reactome: R-HSA-983712;Reactome: R-HSA-77387;Reactome: R-HSA-1222556;Reactome: R-HSA-917977	"Ion channel transport";"Insulin receptor recycling";"ROS and RNS production in phagocytes";"Transferrin endocytosis and recycling"
XP_046425730.1	1	Reactome: R-HSA-1660662	"Glycosphingolipid metabolism"
XP_046427324.1	2	Reactome: R-HSA-8856828;Reactome: R-HSA-8856825	"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis"
XP_046418263.1	29	Reactome: R-HSA-3371453;Reactome: R-HSA-5693565;KEGG: 05170+2.7.11.1;Reactome: R-HSA-6803207;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;Reactome: R-HSA-5693616;KEGG: 04151+2.7.11.1;Reactome: R-HSA-6796648;Reactome: R-HSA-5693571;Reactome: R-HSA-6804756;Reactome: R-HSA-69473;KEGG: 04926+2.7.11.1;Reactome: R-HSA-69541;Reactome: R-HSA-6804760;KEGG: 05163+2.7.11.1;Reactome: R-HSA-5685942;Reactome: R-HSA-6804757;Reactome: R-HSA-5693548;Reactome: R-HSA-912446;Reactome: R-HSA-5693607;Reactome: R-HSA-5693579;Reactome: R-HSA-349425;Reactome: R-HSA-2559586;KEGG: 05165+2.7.11.1;Reactome: R-HSA-5693568;Reactome: R-HSA-5693554;Reactome: R-HSA-6803204;Reactome: R-HSA-5685938	"Regulation of HSF1-mediated heat shock response";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Human immunodeficiency virus 1 infection";"TP53 Regulates Transcription of Caspase Activators and Caspases";"Thermogenesis";"mTOR signaling pathway";"Presynaptic phase of homologous DNA pairing and strand exchange";"PI3K-Akt signaling pathway";"TP53 Regulates Transcription of DNA Repair Genes";"Nonhomologous End-Joining (NHEJ)";"Regulation of TP53 Activity through Phosphorylation";"G2/M DNA damage checkpoint";"Relaxin signaling pathway";"Stabilization of p53";"Regulation of TP53 Activity through Methylation";"Human cytomegalovirus infection";"HDR through Homologous Recombination (HRR)";"Regulation of TP53 Degradation";"Sensing of DNA Double Strand Breaks";"Meiotic recombination";"Processing of DNA double-strand break ends";"Homologous DNA Pairing and Strand Exchange";"Autodegradation of the E3 ubiquitin ligase COP1";"DNA Damage/Telomere Stress Induced Senescence";"Human papillomavirus infection";"Resolution of D-loop Structures through Holliday Junction Intermediates";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"TP53 Regulates Transcription of Genes Involved in Cytochrome C Release";"HDR through Single Strand Annealing (SSA)"
XP_046412472.1	1	KEGG: 00970+6.3.5.7	"Aminoacyl-tRNA biosynthesis"
XP_046430459.1	1	Reactome: R-HSA-1483191	"Synthesis of PC"
XP_046422273.1	4	Reactome: R-HSA-975144;Reactome: R-HSA-937039;Reactome: R-HSA-9020702;MetaCyc: PWY-7511	"IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation";"IRAK1 recruits IKK complex";"Interleukin-1 signaling";"Protein ubiquitination"
XP_046434633.1	8	KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;Reactome: R-HSA-437239	"Human cytomegalovirus infection";"Relaxin signaling pathway";"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Thermogenesis";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Recycling pathway of L1"
XP_046421032.1	16	Reactome: R-HSA-72695;Reactome: R-HSA-1799339;Reactome: R-HSA-72689;Reactome: R-HSA-192823;Reactome: R-HSA-156902;Reactome: R-HSA-72649;Reactome: R-HSA-72764;Reactome: R-HSA-975957;Reactome: R-HSA-72706;Reactome: R-HSA-2408557;Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-72702;Reactome: R-HSA-6791226	"Formation of the ternary complex, and subsequently, the 43S complex";"SRP-dependent cotranslational protein targeting to membrane";"Formation of a pool of free 40S subunits";"Viral mRNA Translation";"Peptide chain elongation";"Translation initiation complex formation";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Selenocysteine synthesis";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Ribosomal scanning and start codon recognition";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046418458.1	2	Reactome: R-HSA-5576893;Reactome: R-HSA-5576892	"Phase 2 - plateau phase";"Phase 0 - rapid depolarisation"
XP_046432334.1	7	Reactome: R-HSA-380270;Reactome: R-HSA-2565942;Reactome: R-HSA-380320;Reactome: R-HSA-380259;Reactome: R-HSA-8854518;Reactome: R-HSA-5620912;Reactome: R-HSA-380284	"Recruitment of mitotic centrosome proteins and complexes";"Regulation of PLK1 Activity at G2/M Transition";"Recruitment of NuMA to mitotic centrosomes";"Loss of Nlp from mitotic centrosomes";"AURKA Activation by TPX2";"Anchoring of the basal body to the plasma membrane";"Loss of proteins required for interphase microtubule organization from the centrosome"
XP_046412274.1	7	MetaCyc: PWY-6124;Reactome: R-HSA-73817;KEGG: 00230+4.3.2.2;MetaCyc: PWY-6123;MetaCyc: PWY-7234;KEGG: 00250+4.3.2.2;MetaCyc: PWY-7219	"Inosine-5'-phosphate biosynthesis II";"Purine ribonucleoside monophosphate biosynthesis";"Purine metabolism";"Inosine-5'-phosphate biosynthesis I";"Inosine-5'-phosphate biosynthesis III";"Alanine, aspartate and glutamate metabolism";"Adenosine ribonucleotides de novo biosynthesis"
XP_046409320.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_046421712.1	1	Reactome: R-HSA-425410	"Metal ion SLC transporters"
XP_046421997.1	2	Reactome: R-HSA-418457;Reactome: R-HSA-1296052	"cGMP effects";"Ca2+ activated K+ channels"
XP_046411738.1	1	KEGG: 00480+3.4.11.2	"Glutathione metabolism"
XP_046433474.1	2	Reactome: R-HSA-8964038;Reactome: R-HSA-6798695	"LDL clearance";"Neutrophil degranulation"
XP_046434071.1	1	Reactome: R-HSA-1296061	"HCN channels"
XP_046418077.1	57	Reactome: R-HSA-6798695;Reactome: R-HSA-983168;Reactome: R-HSA-5658442;Reactome: R-HSA-5607761;Reactome: R-HSA-2467813;Reactome: R-HSA-8939902;Reactome: R-HSA-174184;Reactome: R-HSA-174154;Reactome: R-HSA-202424;Reactome: R-HSA-75815;Reactome: R-HSA-4608870;Reactome: R-HSA-4641257;Reactome: R-HSA-1236978;Reactome: R-HSA-349425;Reactome: R-HSA-8951664;Reactome: R-HSA-5689880;Reactome: R-HSA-174084;Reactome: R-HSA-8939236;Reactome: R-HSA-5610785;Reactome: R-HSA-5678895;Reactome: R-HSA-180585;Reactome: R-HSA-350562;Reactome: R-HSA-9010553;Reactome: R-HSA-8941858;Reactome: R-HSA-5668541;Reactome: R-HSA-211733;Reactome: R-HSA-4641258;Reactome: R-HSA-5632684;Reactome: R-HSA-450408;Reactome: R-HSA-5610780;Reactome: R-HSA-1236974;Reactome: R-HSA-195253;Reactome: R-HSA-2871837;Reactome: R-HSA-174178;Reactome: R-HSA-1169091;Reactome: R-HSA-382556;Reactome: R-HSA-68949;Reactome: R-HSA-5362768;Reactome: R-HSA-5676590;Reactome: R-HSA-9604323;Reactome: R-HSA-69601;Reactome: R-HSA-69017;Reactome: R-HSA-5358346;Reactome: R-HSA-5687128;Reactome: R-HSA-174113;Reactome: R-HSA-9020702;Reactome: R-HSA-8854050;Reactome: R-HSA-5610783;Reactome: R-HSA-8852276;Reactome: R-HSA-69481;Reactome: R-HSA-1234176;Reactome: R-HSA-8948751;Reactome: R-HSA-187577;Reactome: R-HSA-180534;Reactome: R-HSA-5607764;Reactome: R-HSA-68827;Reactome: R-HSA-5689603	"Neutrophil degranulation";"Antigen processing: Ubiquitination & Proteasome degradation";"Regulation of RAS by GAPs";"Dectin-1 mediated noncanonical NF-kB signaling";"Separation of Sister Chromatids";"Regulation of RUNX2 expression and activity";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"APC/C:Cdc20 mediated degradation of Securin";"Downstream TCR signaling";"Ubiquitin-dependent degradation of Cyclin D";"Asymmetric localization of PCP proteins";"Degradation of AXIN";"Cross-presentation of soluble exogenous antigens (endosomes)";"Autodegradation of the E3 ubiquitin ligase COP1";"Neddylation";"Ub-specific processing proteases";"Autodegradation of Cdh1 by Cdh1:APC/C";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"GLI3 is processed to GLI3R by the proteasome";"Defective CFTR causes cystic fibrosis";"Vif-mediated degradation of APOBEC3G";"Regulation of ornithine decarboxylase (ODC)";"Regulation of expression of SLITs and ROBOs";"Regulation of RUNX3 expression and activity";"TNFR2 non-canonical NF-kB pathway";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Degradation of DVL";"Hedgehog 'on' state";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Degradation of GLI1 by the proteasome";"ER-Phagosome pathway";"Degradation of beta-catenin by the destruction complex";"FCERI mediated NF-kB activation";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Activation of NF-kappaB in B cells";"ABC-family proteins mediated transport";"Orc1 removal from chromatin";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"NIK-->noncanonical NF-kB signaling";"Negative regulation of NOTCH4 signaling";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"CDK-mediated phosphorylation and removal of Cdc6";"Hedgehog ligand biogenesis";"MAPK6/MAPK4 signaling";"SCF-beta-TrCP mediated degradation of Emi1";"Interleukin-1 signaling";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Degradation of GLI2 by the proteasome";"The role of GTSE1 in G2/M progression after G2 checkpoint";"G2/M Checkpoints";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of PTEN stability and activity";"SCF(Skp2)-mediated degradation of p27/p21";"Vpu mediated degradation of CD4";"CLEC7A (Dectin-1) signaling";"CDT1 association with the CDC6:ORC:origin complex";"UCH proteinases"
XP_046415098.1	1	MetaCyc: PWY-6308	"L-cysteine biosynthesis II (tRNA-dependent)"
XP_046423728.1	2	KEGG: 00710+2.7.1.14;Reactome: R-HSA-71336	"Carbon fixation in photosynthetic organisms";"Pentose phosphate pathway"
XP_046423428.1	11	Reactome: R-HSA-512988;Reactome: R-HSA-877312;Reactome: R-HSA-210990;Reactome: R-HSA-388841;Reactome: R-HSA-391160;Reactome: R-HSA-912694;Reactome: R-HSA-389948;Reactome: R-HSA-432142;Reactome: R-HSA-114604;Reactome: R-HSA-909733;Reactome: R-HSA-9008059	"Interleukin-3, Interleukin-5 and GM-CSF signaling";"Regulation of IFNG signaling";"PECAM1 interactions";"Costimulation by the CD28 family";"Signal regulatory protein family interactions";"Regulation of IFNA signaling";"PD-1 signaling";"Platelet sensitization by LDL";"GPVI-mediated activation cascade";"Interferon alpha/beta signaling";"Interleukin-37 signaling"
XP_046433082.1	3	Reactome: R-HSA-6798695;Reactome: R-HSA-6807004;Reactome: R-HSA-202427	"Neutrophil degranulation";"Negative regulation of MET activity";"Phosphorylation of CD3 and TCR zeta chains"
XP_046411450.1	5	Reactome: R-HSA-196807;MetaCyc: PWY-7268;MetaCyc: PWY-5083;MetaCyc: PWY-7269;KEGG: 00760+2.7.1.23	"Nicotinate metabolism";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"NAD/NADH phosphorylation and dephosphorylation";"NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)";"Nicotinate and nicotinamide metabolism"
XP_046428850.1	6	Reactome: R-HSA-5358565;Reactome: R-HSA-912446;Reactome: R-HSA-6796648;Reactome: R-HSA-5632987;Reactome: R-HSA-5358606;Reactome: R-HSA-5545483	"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"Meiotic recombination";"TP53 Regulates Transcription of DNA Repair Genes";"Defective Mismatch Repair Associated With PMS2";"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"Defective Mismatch Repair Associated With MLH1"
XP_046425273.1	1	Reactome: R-HSA-5689880	"Ub-specific processing proteases"
XP_046418877.1	1	Reactome: R-HSA-212436	"Generic Transcription Pathway"
XP_046431481.1	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276	"Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination"
XP_046417736.1	2	Reactome: R-HSA-416993;Reactome: R-HSA-202733	"Trafficking of GluR2-containing AMPA receptors";"Cell surface interactions at the vascular wall"
XP_046421706.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_046432579.1	1	Reactome: R-HSA-71403	"Citric acid cycle (TCA cycle)"
XP_046428748.1	5	Reactome: R-HSA-168164;Reactome: R-HSA-937041;Reactome: R-HSA-936964;Reactome: R-HSA-166166;Reactome: R-HSA-937072	"Toll Like Receptor 3 (TLR3) Cascade";"IKK complex recruitment mediated by RIP1";"Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon";"MyD88-independent TLR4 cascade";"TRAF6-mediated induction of TAK1 complex within TLR4 complex"
XP_046430048.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046424925.1	1	Reactome: R-HSA-432720	"Lysosome Vesicle Biogenesis"
XP_046430262.1	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
XP_046426497.1	2	Reactome: R-HSA-5619039;Reactome: R-HSA-426117	"Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)";"Cation-coupled Chloride cotransporters"
XP_046431574.1	6	KEGG: 00760+6.3.5.1;KEGG: 00760+6.3.1.5;MetaCyc: PWY-5653;MetaCyc: PWY-5381;MetaCyc: PWY-7761;Reactome: R-HSA-196807	"Nicotinate and nicotinamide metabolism";"Nicotinate and nicotinamide metabolism";"NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde";"Pyridine nucleotide cycling (plants)";"NAD salvage pathway II (PNC IV cycle)";"Nicotinate metabolism"
XP_046410174.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_046422621.1	6	MetaCyc: PWY-7782;MetaCyc: PWY-5884;MetaCyc: PWY-6733;Reactome: R-HSA-9640463;MetaCyc: PWY-7656;KEGG: 00073+1.2.1.84	"Plasmalogen biosynthesis";"Wax esters biosynthesis I";"Sporopollenin precursors biosynthesis";"Wax biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Cutin, suberine and wax biosynthesis"
XP_046413426.1	11	Reactome: R-HSA-1250196;Reactome: R-HSA-6811558;Reactome: R-HSA-8863795;Reactome: R-HSA-1963642;Reactome: R-HSA-2219530;Reactome: R-HSA-6785631;Reactome: R-HSA-5673001;Reactome: R-HSA-1227986;Reactome: R-HSA-1257604;Reactome: R-HSA-8847993;Reactome: R-HSA-9664565	"SHC1 events in ERBB2 signaling";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"Downregulation of ERBB2 signaling";"PI3K events in ERBB2 signaling";"Constitutive Signaling by Aberrant PI3K in Cancer";"ERBB2 Regulates Cell Motility";"RAF/MAP kinase cascade";"Signaling by ERBB2";"PIP3 activates AKT signaling";"ERBB2 Activates PTK6 Signaling";"Signaling by ERBB2 KD Mutants"
XP_046410134.1	6	KEGG: 00562+3.1.3.66;MetaCyc: PWY-6368;Reactome: R-HSA-1855183;Reactome: R-HSA-1660516;Reactome: R-HSA-1660499;KEGG: 04070+3.1.3.66	"Inositol phosphate metabolism";"3-phosphoinositide degradation";"Synthesis of IP2, IP, and Ins in the cytosol";"Synthesis of PIPs at the early endosome membrane";"Synthesis of PIPs at the plasma membrane";"Phosphatidylinositol signaling system"
XP_046428805.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_046425984.1	1	Reactome: R-HSA-399956	"CRMPs in Sema3A signaling"
XP_046423624.1	6	Reactome: R-HSA-6791226;Reactome: R-HSA-450385;Reactome: R-HSA-450604;Reactome: R-HSA-450513;Reactome: R-HSA-429958;Reactome: R-HSA-380994	"Major pathway of rRNA processing in the nucleolus and cytosol";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"KSRP (KHSRP) binds and destabilizes mRNA";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"mRNA decay by 3' to 5' exoribonuclease";"ATF4 activates genes in response to endoplasmic reticulum stress"
XP_046410010.1	1	Reactome: R-HSA-2022928	"HS-GAG biosynthesis"
XP_046413339.1	5	MetaCyc: PWY-6527;KEGG: 00520+2.7.1.6;KEGG: 00052+2.7.1.6;MetaCyc: PWY-3821;MetaCyc: PWY-6317	"Stachyose degradation";"Amino sugar and nucleotide sugar metabolism";"Galactose metabolism";"D-galactose detoxification";"D-galactose degradation I (Leloir pathway)"
XP_046416792.1	5	MetaCyc: PWY-6558;KEGG: 00534+2.4.1.224+2.4.1.225;Reactome: R-HSA-3656237;Reactome: R-HSA-2022928;Reactome: R-HSA-3656253	"Heparan sulfate biosynthesis (late stages)";"Glycosaminoglycan biosynthesis - heparan sulfate / heparin";"Defective EXT2 causes exostoses 2";"HS-GAG biosynthesis";"Defective EXT1 causes exostoses 1, TRPS2 and CHDS"
XP_046425392.1	5	Reactome: R-HSA-196108;Reactome: R-HSA-5579026;Reactome: R-HSA-1362409;Reactome: R-HSA-2395516;Reactome: R-HSA-211976	"Pregnenolone biosynthesis";"Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)";"Mitochondrial iron-sulfur cluster biogenesis";"Electron transport from NADPH to Ferredoxin";"Endogenous sterols"
XP_046424031.1	1	Reactome: R-HSA-880009	"Interconversion of 2-oxoglutarate and 2-hydroxyglutarate"
XP_046419568.1	7	MetaCyc: PWY-7511;Reactome: R-HSA-2691232;Reactome: R-HSA-2979096;Reactome: R-HSA-9013507;Reactome: R-HSA-2644606;Reactome: R-HSA-2894862;Reactome: R-HSA-2122948	"Protein ubiquitination";"Constitutive Signaling by NOTCH1 HD Domain Mutants";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Activated NOTCH1 Transmits Signal to the Nucleus"
XP_046410892.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_046420990.1	1	Reactome: R-HSA-1655829	"Regulation of cholesterol biosynthesis by SREBP (SREBF)"
XP_046421859.1	3	Reactome: R-HSA-1445148;Reactome: R-HSA-264876;Reactome: R-HSA-5620916	"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Insulin processing";"VxPx cargo-targeting to cilium"
XP_046420294.1	15	Reactome: R-HSA-5467348;Reactome: R-HSA-5467337;Reactome: R-HSA-5358749;Reactome: R-HSA-5689896;Reactome: R-HSA-196299;Reactome: R-HSA-5358747;Reactome: R-HSA-111465;Reactome: R-HSA-4641262;Reactome: R-HSA-5467340;Reactome: R-HSA-5339716;Reactome: R-HSA-3769402;Reactome: R-HSA-5358751;Reactome: R-HSA-5467333;Reactome: R-HSA-195253;Reactome: R-HSA-5358752	"Truncations of AMER1 destabilize the destruction complex";"APC truncation mutants have impaired AXIN binding";"S37 mutants of beta-catenin aren't phosphorylated";"Ovarian tumor domain proteases";"Beta-catenin phosphorylation cascade";"S33 mutants of beta-catenin aren't phosphorylated";"Apoptotic cleavage of cellular proteins";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"AXIN missense mutants destabilize the destruction complex";"Misspliced GSK3beta mutants stabilize beta-catenin";"Deactivation of the beta-catenin transactivating complex";"S45 mutants of beta-catenin aren't phosphorylated";"APC truncation mutants are not K63 polyubiquitinated";"Degradation of beta-catenin by the destruction complex";"T41 mutants of beta-catenin aren't phosphorylated"
XP_046431025.1	4	KEGG: 04660+3.1.3.16;Reactome: R-HSA-180024;KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16	"T cell receptor signaling pathway";"DARPP-32 events";"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
XP_046412812.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_046427718.1	14	MetaCyc: PWY-561;MetaCyc: PWY-7254;MetaCyc: PWY-4302;MetaCyc: PWY-6969;MetaCyc: PWY-6728;KEGG: 00650+1.3.5.1;Reactome: R-HSA-611105;KEGG: 00720+1.3.5.1;KEGG: 00190+1.3.5.1;KEGG: 00020+1.3.5.1;MetaCyc: PWY-5690;Reactome: R-HSA-71403;MetaCyc: PWY-7279;MetaCyc: PWY-3781	"Superpathway of glyoxylate cycle and fatty acid degradation";"TCA cycle VII (acetate-producers)";"Aerobic respiration III (alternative oxidase pathway)";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Methylaspartate cycle";"Butanoate metabolism";"Respiratory electron transport";"Carbon fixation pathways in prokaryotes";"Oxidative phosphorylation";"Citrate cycle (TCA cycle)";"TCA cycle II (plants and fungi)";"Citric acid cycle (TCA cycle)";"Aerobic respiration II (cytochrome c) (yeast)";"Aerobic respiration I (cytochrome c)"
XP_046434363.1	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
XP_046421041.1	2	Reactome: R-HSA-3295583;Reactome: R-HSA-418890	"TRP channels";"Role of second messengers in netrin-1 signaling"
XP_046425818.1	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
XP_046418451.1	2	Reactome: R-HSA-5687128;KEGG: 04150+2.7.11.24	"MAPK6/MAPK4 signaling";"mTOR signaling pathway"
XP_046436695.1	12	Reactome: R-HSA-2132295;Reactome: R-HSA-141444;Reactome: R-HSA-9648025;Reactome: R-HSA-9646399;Reactome: R-HSA-2467813;Reactome: R-HSA-6811436;Reactome: R-HSA-68877;Reactome: R-HSA-9609690;Reactome: R-HSA-2500257;Reactome: R-HSA-5663220;Reactome: R-HSA-3371497;Reactome: R-HSA-6807878	"MHC class II antigen presentation";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"EML4 and NUDC in mitotic spindle formation";"Aggrephagy";"Separation of Sister Chromatids";"COPI-independent Golgi-to-ER retrograde traffic";"Mitotic Prometaphase";"HCMV Early Events";"Resolution of Sister Chromatid Cohesion";"RHO GTPases Activate Formins";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-mediated anterograde transport"
XP_046426620.1	4	MetaCyc: PWY-8004;KEGG: 00030+1.1.1.49;KEGG: 00480+1.1.1.49;MetaCyc: PWY-7268	"Entner-Doudoroff pathway I";"Pentose phosphate pathway";"Glutathione metabolism";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)"
XP_046431043.1	3	Reactome: R-HSA-420029;MetaCyc: PWY-7221;KEGG: 00230+2.7.4.8	"Tight junction interactions";"Guanosine ribonucleotides de novo biosynthesis";"Purine metabolism"
XP_046426011.1	20	MetaCyc: PWY-7854;MetaCyc: PWY-7007;MetaCyc: PWY-7726;MetaCyc: PWY-7606;MetaCyc: PWY-7340;MetaCyc: PWY-7288;MetaCyc: PWY-7337;MetaCyc: PWY-7574;MetaCyc: PWY-6920;MetaCyc: PWY-7858;MetaCyc: PWY-7291;KEGG: 00071+1.3.3.6;MetaCyc: PWY-7338;MetaCyc: PWY-6837;MetaCyc: PWY-735;KEGG: 00640+1.3.3.6;KEGG: 00592+1.3.3.6;MetaCyc: PWY-5136;KEGG: 00410+1.3.3.6;Reactome: R-HSA-9033241	"Crotonyl-coa/ethylmalonyl-coa/hydroxybutyryl-coa cycle (engineered)";"Methyl ketone biosynthesis (engineered)";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast)";"Fatty acid beta-oxidation VII (yeast peroxisome)";"10-cis-heptadecenoyl-CoA degradation (yeast)";"Propanoyl-coa degradation II";"6-gingerol analog biosynthesis (engineered)";"(5Z)-dodecenoate biosynthesis II";"Oleate beta-oxidation (isomerase-dependent, yeast)";"Fatty acid degradation";"10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast)";"Fatty acid beta-oxidation V (unsaturated, odd number, di-isomerase-dependent)";"Jasmonic acid biosynthesis";"Propanoate metabolism";"alpha-Linolenic acid metabolism";"Fatty acid beta-oxidation II (plant peroxisome)";"beta-Alanine metabolism";"Peroxisomal protein import"
XP_046433053.1	57	Reactome: R-HSA-2467813;Reactome: R-HSA-174154;Reactome: R-HSA-8939902;Reactome: R-HSA-174184;Reactome: R-HSA-6798695;Reactome: R-HSA-5607761;Reactome: R-HSA-5658442;Reactome: R-HSA-983168;Reactome: R-HSA-8939236;Reactome: R-HSA-5678895;Reactome: R-HSA-180585;Reactome: R-HSA-5610785;Reactome: R-HSA-1236978;Reactome: R-HSA-202424;Reactome: R-HSA-75815;Reactome: R-HSA-4641257;Reactome: R-HSA-4608870;Reactome: R-HSA-8951664;Reactome: R-HSA-174084;Reactome: R-HSA-5689880;Reactome: R-HSA-349425;Reactome: R-HSA-382556;Reactome: R-HSA-1169091;Reactome: R-HSA-68949;Reactome: R-HSA-195253;Reactome: R-HSA-2871837;Reactome: R-HSA-174178;Reactome: R-HSA-5676590;Reactome: R-HSA-9604323;Reactome: R-HSA-5362768;Reactome: R-HSA-69601;Reactome: R-HSA-5358346;Reactome: R-HSA-69017;Reactome: R-HSA-9010553;Reactome: R-HSA-350562;Reactome: R-HSA-8941858;Reactome: R-HSA-5668541;Reactome: R-HSA-5610780;Reactome: R-HSA-450408;Reactome: R-HSA-1236974;Reactome: R-HSA-4641258;Reactome: R-HSA-211733;Reactome: R-HSA-5632684;Reactome: R-HSA-69481;Reactome: R-HSA-8948751;Reactome: R-HSA-1234176;Reactome: R-HSA-5610783;Reactome: R-HSA-8852276;Reactome: R-HSA-68827;Reactome: R-HSA-5689603;Reactome: R-HSA-180534;Reactome: R-HSA-187577;Reactome: R-HSA-5607764;Reactome: R-HSA-174113;Reactome: R-HSA-5687128;Reactome: R-HSA-8854050;Reactome: R-HSA-9020702	"Separation of Sister Chromatids";"APC/C:Cdc20 mediated degradation of Securin";"Regulation of RUNX2 expression and activity";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Neutrophil degranulation";"Dectin-1 mediated noncanonical NF-kB signaling";"Regulation of RAS by GAPs";"Antigen processing: Ubiquitination & Proteasome degradation";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Defective CFTR causes cystic fibrosis";"Vif-mediated degradation of APOBEC3G";"GLI3 is processed to GLI3R by the proteasome";"Cross-presentation of soluble exogenous antigens (endosomes)";"Downstream TCR signaling";"Ubiquitin-dependent degradation of Cyclin D";"Degradation of AXIN";"Asymmetric localization of PCP proteins";"Neddylation";"Autodegradation of Cdh1 by Cdh1:APC/C";"Ub-specific processing proteases";"Autodegradation of the E3 ubiquitin ligase COP1";"ABC-family proteins mediated transport";"Activation of NF-kappaB in B cells";"Orc1 removal from chromatin";"Degradation of beta-catenin by the destruction complex";"FCERI mediated NF-kB activation";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"NIK-->noncanonical NF-kB signaling";"Negative regulation of NOTCH4 signaling";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Hedgehog ligand biogenesis";"CDK-mediated phosphorylation and removal of Cdc6";"Regulation of expression of SLITs and ROBOs";"Regulation of ornithine decarboxylase (ODC)";"Regulation of RUNX3 expression and activity";"TNFR2 non-canonical NF-kB pathway";"Degradation of GLI1 by the proteasome";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"ER-Phagosome pathway";"Degradation of DVL";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Hedgehog 'on' state";"G2/M Checkpoints";"Regulation of PTEN stability and activity";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Degradation of GLI2 by the proteasome";"The role of GTSE1 in G2/M progression after G2 checkpoint";"CDT1 association with the CDC6:ORC:origin complex";"UCH proteinases";"Vpu mediated degradation of CD4";"SCF(Skp2)-mediated degradation of p27/p21";"CLEC7A (Dectin-1) signaling";"SCF-beta-TrCP mediated degradation of Emi1";"MAPK6/MAPK4 signaling";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Interleukin-1 signaling"
XP_046425832.1	6	Reactome: R-HSA-2500257;Reactome: R-HSA-5663220;Reactome: R-HSA-2467813;Reactome: R-HSA-68877;Reactome: R-HSA-141444;Reactome: R-HSA-9648025	"Resolution of Sister Chromatid Cohesion";"RHO GTPases Activate Formins";"Separation of Sister Chromatids";"Mitotic Prometaphase";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"EML4 and NUDC in mitotic spindle formation"
XP_046419675.1	10	KEGG: 04150+2.7.1.153;KEGG: 04070+2.7.1.153;Reactome: R-HSA-1660499;KEGG: 04151+2.7.1.153;Reactome: R-HSA-9027276;MetaCyc: PWY-6352;KEGG: 00562+2.7.1.153;KEGG: 05163+2.7.1.153;KEGG: 05170+2.7.1.153;KEGG: 05165+2.7.1.153	"mTOR signaling pathway";"Phosphatidylinositol signaling system";"Synthesis of PIPs at the plasma membrane";"PI3K-Akt signaling pathway";"Erythropoietin activates Phosphoinositide-3-kinase (PI3K)";"3-phosphoinositide biosynthesis";"Inositol phosphate metabolism";"Human cytomegalovirus infection";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection"
XP_046432091.1	7	KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04926+2.7.11.1	"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Thermogenesis";"Human cytomegalovirus infection";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Relaxin signaling pathway"
XP_046426422.1	9	Reactome: R-HSA-382556;Reactome: R-HSA-5627083;Reactome: R-HSA-9646399;Reactome: R-HSA-5678895;Reactome: R-HSA-8856828;Reactome: R-HSA-8856825;Reactome: R-HSA-9615710;Reactome: R-HSA-9613829;Reactome: R-HSA-5689880	"ABC-family proteins mediated transport";"RHO GTPases regulate CFTR trafficking";"Aggrephagy";"Defective CFTR causes cystic fibrosis";"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis";"Late endosomal microautophagy";"Chaperone Mediated Autophagy";"Ub-specific processing proteases"
XP_046427670.1	3	Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-212436	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"Generic Transcription Pathway"
XP_046422868.1	1	Reactome: R-HSA-6794361	"Neurexins and neuroligins"
XP_046434482.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_046416013.1	1	Reactome: R-HSA-389957	"Prefoldin mediated transfer of substrate to CCT/TriC"
XP_046432538.1	5	KEGG: 00052+3.2.1.22;MetaCyc: PWY-6527;KEGG: 00603+3.2.1.22;KEGG: 00600+3.2.1.22;KEGG: 00561+3.2.1.22	"Galactose metabolism";"Stachyose degradation";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Sphingolipid metabolism";"Glycerolipid metabolism"
XP_046423942.1	14	MetaCyc: PWY-7035;MetaCyc: PWY-8041;MetaCyc: PWY-6598;MetaCyc: PWY-7602;MetaCyc: PWY-7036;MetaCyc: PWY-5080;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7601;MetaCyc: PWY-7619;MetaCyc: PWY-7725;MetaCyc: PWY-7724;Reactome: R-HSA-75876;MetaCyc: PWY-5972;MetaCyc: PWY-6433	"(9Z)-tricosene biosynthesis";"Ultra-long-chain fatty acid biosynthesis";"Sciadonate biosynthesis";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis II";"Very long chain fatty acid biosynthesis I";"Fatty acid elongation";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Juniperonate biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Synthesis of very long-chain fatty acyl-CoAs";"Stearate biosynthesis I (animals)";"Hydroxylated fatty acid biosynthesis (plants)"
XP_046422730.1	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
XP_046434936.1	3	Reactome: R-HSA-73856;Reactome: R-HSA-159236;Reactome: R-HSA-72187	"RNA Polymerase II Transcription Termination";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"mRNA 3'-end processing"
XP_046427131.1	1	Reactome: R-HSA-420499	"Class C/3 (Metabotropic glutamate/pheromone receptors)"
XP_046413066.1	5	Reactome: R-HSA-9649948;Reactome: R-HSA-5675221;Reactome: R-HSA-6802955;Reactome: R-HSA-6802946;Reactome: R-HSA-5673000	"Signaling downstream of RAS mutants";"Negative regulation of MAPK pathway";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"Signaling by moderate kinase activity BRAF mutants";"RAF activation"
XP_046418753.1	14	MetaCyc: PWY-7039;MetaCyc: PWY-6351;KEGG: 00562+3.1.4.11;KEGG: 04070+3.1.4.11;Reactome: R-HSA-500657;Reactome: R-HSA-1855204;Reactome: R-HSA-416476;Reactome: R-HSA-418217;MetaCyc: PWY-8052;Reactome: R-HSA-434316;Reactome: R-HSA-4086398;Reactome: R-HSA-112043;MetaCyc: PWY-6367;Reactome: R-HSA-399997	"Phosphatidate metabolism, as a signaling molecule";"D-myo-inositol (1,4,5)-trisphosphate biosynthesis";"Inositol phosphate metabolism";"Phosphatidylinositol signaling system";"Presynaptic function of Kainate receptors";"Synthesis of IP3 and IP4 in the cytosol";"G alpha (q) signalling events";"G beta:gamma signalling through PLC beta";"2-arachidonoylglycerol biosynthesis";"Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion";"Ca2+ pathway";"PLC beta mediated events";"D-myo-inositol-5-phosphate metabolism";"Acetylcholine regulates insulin secretion"
XP_046417871.1	12	MetaCyc: PWY-1042;KEGG: 00051+4.1.2.13;MetaCyc: PWY-7385;MetaCyc: PWY-1861;KEGG: 00680+4.1.2.13;Reactome: R-HSA-70171;KEGG: 00010+4.1.2.13;MetaCyc: PWY-5484;Reactome: R-HSA-70263;MetaCyc: PWY-6142;KEGG: 00710+4.1.2.13;KEGG: 00030+4.1.2.13	"Glycolysis IV (plant cytosol)";"Fructose and mannose metabolism";"1,3-propanediol biosynthesis (engineered)";"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"Methane metabolism";"Glycolysis";"Glycolysis / Gluconeogenesis";"Glycolysis II (from fructose 6-phosphate)";"Gluconeogenesis";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Carbon fixation in photosynthetic organisms";"Pentose phosphate pathway"
XP_046435026.1	8	Reactome: R-HSA-2565942;Reactome: R-HSA-380320;Reactome: R-HSA-380259;Reactome: R-HSA-380284;Reactome: R-HSA-380270;Reactome: R-HSA-6798695;Reactome: R-HSA-8854518;Reactome: R-HSA-5620912	"Regulation of PLK1 Activity at G2/M Transition";"Recruitment of NuMA to mitotic centrosomes";"Loss of Nlp from mitotic centrosomes";"Loss of proteins required for interphase microtubule organization from the centrosome";"Recruitment of mitotic centrosome proteins and complexes";"Neutrophil degranulation";"AURKA Activation by TPX2";"Anchoring of the basal body to the plasma membrane"
XP_046426517.1	1	Reactome: R-HSA-72203	"Processing of Capped Intron-Containing Pre-mRNA"
XP_046434873.1	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
XP_046409312.1	9	KEGG: 00511+3.2.1.52;KEGG: 00603+3.2.1.52;KEGG: 00604+3.2.1.52;MetaCyc: PWY-7883;KEGG: 00520+3.2.1.52;KEGG: 00531+3.2.1.52;MetaCyc: PWY-6902;KEGG: 00513+3.2.1.52;MetaCyc: PWY-7822	"Other glycan degradation";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Glycosphingolipid biosynthesis - ganglio series";"Anhydromuropeptides recycling II";"Amino sugar and nucleotide sugar metabolism";"Glycosaminoglycan degradation";"Chitin degradation II (Vibrio)";"Various types of N-glycan biosynthesis";"Chitin degradation III (Serratia)"
XP_046429186.1	6	KEGG: 00512+2.4.1.122;Reactome: R-HSA-5083632;Reactome: R-HSA-913709;KEGG: 00514+2.4.1.122;MetaCyc: PWY-7433;MetaCyc: PWY-7290	"Mucin type O-glycan biosynthesis";"Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)";"O-linked glycosylation of mucins";"Other types of O-glycan biosynthesis";"Mucin core 1 and core 2 O-glycosylation";"Escherichia coli serotype O86 O-antigen biosynthesis"
XP_046427052.1	2	Reactome: R-HSA-72163;Reactome: R-HSA-72165	"mRNA Splicing - Major Pathway";"mRNA Splicing - Minor Pathway"
XP_046431719.1	1	Reactome: R-HSA-2151201	"Transcriptional activation of mitochondrial biogenesis"
XP_046412987.1	25	Reactome: R-HSA-8939256;Reactome: R-HSA-8941326;Reactome: R-HSA-8931987;Reactome: R-HSA-8941332;Reactome: R-HSA-8949275;Reactome: R-HSA-8877330;Reactome: R-HSA-8934593;Reactome: R-HSA-8939236;Reactome: R-HSA-8951936;Reactome: R-HSA-8941284;Reactome: R-HSA-8941333;Reactome: R-HSA-8939242;Reactome: R-HSA-9616222;Reactome: R-HSA-8941858;Reactome: R-HSA-8939243;Reactome: R-HSA-8878166;Reactome: R-HSA-8951911;Reactome: R-HSA-8940973;Reactome: R-HSA-8935964;Reactome: R-HSA-8939247;Reactome: R-HSA-9018519;Reactome: R-HSA-8939245;Reactome: R-HSA-8939246;Reactome: R-HSA-8936459;Reactome: R-HSA-8939902	"RUNX1 regulates transcription of genes involved in WNT signaling";"RUNX2 regulates bone development";"RUNX1 regulates estrogen receptor mediated transcription";"RUNX2 regulates genes involved in cell migration";"RUNX3 Regulates Immune Response and Cell Migration";"RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)";"Regulation of RUNX1 Expression and Activity";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"RUNX3 regulates p14-ARF";"RUNX2 regulates chondrocyte maturation";"RUNX2 regulates genes involved in differentiation of myeloid cells";"RUNX1 regulates transcription of genes involved in differentiation of keratinocytes";"Transcriptional regulation of granulopoiesis";"Regulation of RUNX3 expression and activity";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"Transcriptional regulation by RUNX2";"RUNX3 regulates RUNX1-mediated transcription";"RUNX2 regulates osteoblast differentiation";"RUNX1 regulates expression of components of tight junctions";"RUNX1 regulates transcription of genes involved in interleukin signaling";"Estrogen-dependent gene expression";"RUNX1 regulates transcription of genes involved in BCR signaling";"RUNX1 regulates transcription of genes involved in differentiation of myeloid cells";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Regulation of RUNX2 expression and activity"
XP_046425186.1	1	Reactome: R-HSA-418990	"Adherens junctions interactions"
XP_046419065.1	1	Reactome: R-HSA-5658442	"Regulation of RAS by GAPs"
XP_046424603.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046409366.1	9	MetaCyc: PWY-6142;MetaCyc: PWY-5789;MetaCyc: PWY-241;Reactome: R-HSA-1475029;KEGG: 00910+4.2.1.1;MetaCyc: PWY-7115;MetaCyc: PWY-7117;MetaCyc: PWY-5744;MetaCyc: PWY-5743	"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"3-hydroxypropanoate/4-hydroxybutanate cycle";"C4 photosynthetic carbon assimilation cycle, NADP-ME type";"Reversible hydration of carbon dioxide";"Nitrogen metabolism";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"C4 photosynthetic carbon assimilation cycle, PEPCK type";"Glyoxylate assimilation";"3-hydroxypropanoate cycle"
XP_046436715.1	4	Reactome: R-HSA-5607761;Reactome: R-HSA-5676590;Reactome: R-HSA-8951664;Reactome: R-HSA-983168	"Dectin-1 mediated noncanonical NF-kB signaling";"NIK-->noncanonical NF-kB signaling";"Neddylation";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046417109.1	3	Reactome: R-HSA-4420097;Reactome: R-HSA-5663213;Reactome: R-HSA-2029482	"VEGFA-VEGFR2 Pathway";"RHO GTPases Activate WASPs and WAVEs";"Regulation of actin dynamics for phagocytic cup formation"
XP_046434098.1	2	Reactome: R-HSA-426486;Reactome: R-HSA-203927	"Small interfering RNA (siRNA) biogenesis";"MicroRNA (miRNA) biogenesis"
XP_046416974.1	1	Reactome: R-HSA-6794361	"Neurexins and neuroligins"
XP_046413138.1	6	Reactome: R-HSA-173599;KEGG: 00053+1.1.1.22;KEGG: 00520+1.1.1.22;KEGG: 00040+1.1.1.22;MetaCyc: PWY-7820;MetaCyc: PWY-7346	"Formation of the active cofactor, UDP-glucuronate";"Ascorbate and aldarate metabolism";"Amino sugar and nucleotide sugar metabolism";"Pentose and glucuronate interconversions";"Teichuronic acid biosynthesis (B. subtilis 168)";"UDP-alpha-D-glucuronate biosynthesis (from UDP-glucose)"
XP_046415720.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_046432449.1	5	Reactome: R-HSA-8856828;Reactome: R-HSA-8875360;Reactome: R-HSA-6807004;Reactome: R-HSA-182971;Reactome: R-HSA-8856825	"Clathrin-mediated endocytosis";"InlB-mediated entry of Listeria monocytogenes into host cell";"Negative regulation of MET activity";"EGFR downregulation";"Cargo recognition for clathrin-mediated endocytosis"
XP_046416078.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046434817.1	3	Reactome: R-HSA-5620916;Reactome: R-HSA-264876;Reactome: R-HSA-1445148	"VxPx cargo-targeting to cilium";"Insulin processing";"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
XP_046419458.1	1	Reactome: R-HSA-2559584	"Formation of Senescence-Associated Heterochromatin Foci (SAHF)"
XP_046435691.1	1	MetaCyc: PWY-6308	"L-cysteine biosynthesis II (tRNA-dependent)"
XP_046410758.1	1	Reactome: R-HSA-9609523	"Insertion of tail-anchored proteins into the endoplasmic reticulum membrane"
XP_046415236.1	10	Reactome: R-HSA-72706;Reactome: R-HSA-72695;Reactome: R-HSA-9648895;Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-72731;Reactome: R-HSA-72702;Reactome: R-HSA-72649;Reactome: R-HSA-381042;Reactome: R-HSA-382556	"GTP hydrolysis and joining of the 60S ribosomal subunit";"Formation of the ternary complex, and subsequently, the 43S complex";"Response of EIF2AK1 (HRI) to heme deficiency";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"Recycling of eIF2:GDP";"Ribosomal scanning and start codon recognition";"Translation initiation complex formation";"PERK regulates gene expression";"ABC-family proteins mediated transport"
XP_046423268.1	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
XP_046436453.1	2	Reactome: R-HSA-8866654;Reactome: R-HSA-9033241	"E3 ubiquitin ligases ubiquitinate target proteins";"Peroxisomal protein import"
XP_046433788.1	9	Reactome: R-HSA-6781827;Reactome: R-HSA-5696400;Reactome: R-HSA-6782135;Reactome: R-HSA-5696395;Reactome: R-HSA-110314;Reactome: R-HSA-6781823;Reactome: R-HSA-8951664;Reactome: R-HSA-6782210;Reactome: R-HSA-5696394	"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Dual Incision in GG-NER";"Dual incision in TC-NER";"Formation of Incision Complex in GG-NER";"Recognition of DNA damage by PCNA-containing replication complex";"Formation of TC-NER Pre-Incision Complex";"Neddylation";"Gap-filling DNA repair synthesis and ligation in TC-NER";"DNA Damage Recognition in GG-NER"
XP_046422704.1	1	Reactome: R-HSA-425561	"Sodium/Calcium exchangers"
XP_046424084.1	2	Reactome: R-HSA-71403;Reactome: R-HSA-611105	"Citric acid cycle (TCA cycle)";"Respiratory electron transport"
XP_046432092.1	7	KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1	"Thermogenesis";"Human cytomegalovirus infection";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Relaxin signaling pathway";"mTOR signaling pathway";"PI3K-Akt signaling pathway"
XP_046428737.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_046417384.1	14	Reactome: R-HSA-168333;Reactome: R-HSA-165054;Reactome: R-HSA-5687128;Reactome: R-HSA-450520;Reactome: R-HSA-69273;Reactome: R-HSA-5663220;Reactome: R-HSA-2500257;Reactome: R-HSA-9634638;Reactome: R-HSA-9648025;Reactome: R-HSA-141444;Reactome: R-HSA-68877;Reactome: R-HSA-2173788;Reactome: R-HSA-2467813;Reactome: R-HSA-3769402	"NEP/NS2 Interacts with the Cellular Export Machinery";"Rev-mediated nuclear export of HIV RNA";"MAPK6/MAPK4 signaling";"HuR (ELAVL1) binds and stabilizes mRNA";"Cyclin A/B1/B2 associated events during G2/M transition";"RHO GTPases Activate Formins";"Resolution of Sister Chromatid Cohesion";"Estrogen-dependent nuclear events downstream of ESR-membrane signaling";"EML4 and NUDC in mitotic spindle formation";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Mitotic Prometaphase";"Downregulation of TGF-beta receptor signaling";"Separation of Sister Chromatids";"Deactivation of the beta-catenin transactivating complex"
XP_046435702.1	1	Reactome: R-HSA-1237044	"Erythrocytes take up carbon dioxide and release oxygen"
XP_046432931.1	1	Reactome: R-HSA-1971475	"A tetrasaccharide linker sequence is required for GAG synthesis"
XP_046420708.1	14	MetaCyc: PWY-8041;MetaCyc: PWY-7036;MetaCyc: PWY-6598;MetaCyc: PWY-7602;MetaCyc: PWY-7035;MetaCyc: PWY-7619;MetaCyc: PWY-7725;MetaCyc: PWY-5080;MetaCyc: PWY-7601;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7724;Reactome: R-HSA-75876;MetaCyc: PWY-5972;MetaCyc: PWY-6433	"Ultra-long-chain fatty acid biosynthesis";"Very long chain fatty acid biosynthesis II";"Sciadonate biosynthesis";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"(9Z)-tricosene biosynthesis";"Juniperonate biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Very long chain fatty acid biosynthesis I";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Fatty acid elongation";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Synthesis of very long-chain fatty acyl-CoAs";"Stearate biosynthesis I (animals)";"Hydroxylated fatty acid biosynthesis (plants)"
XP_046412357.1	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
XP_046421757.1	2	Reactome: R-HSA-6798695;Reactome: R-HSA-8951664	"Neutrophil degranulation";"Neddylation"
XP_046427033.1	3	KEGG: 00730+3.1.3.1;KEGG: 00790+3.1.3.1;MetaCyc: PWY-5491	"Thiamine metabolism";"Folate biosynthesis";"Diethylphosphate degradation"
XP_046428305.1	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
XP_046431232.1	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286	"Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation"
XP_046419064.1	1	Reactome: R-HSA-5658442	"Regulation of RAS by GAPs"
XP_046412853.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046418413.1	7	MetaCyc: PWY-7625;Reactome: R-HSA-1483226;MetaCyc: PWY-6352;KEGG: 00562+2.7.8.11;MetaCyc: PWY-6351;KEGG: 00564+2.7.8.11;KEGG: 04070+2.7.8.11	"Phosphatidylinositol biosynthesis II (eukaryotes)";"Synthesis of PI";"3-phosphoinositide biosynthesis";"Inositol phosphate metabolism";"D-myo-inositol (1,4,5)-trisphosphate biosynthesis";"Glycerophospholipid metabolism";"Phosphatidylinositol signaling system"
XP_046413247.1	1	Reactome: R-HSA-6811440	"Retrograde transport at the Trans-Golgi-Network"
XP_046410808.1	2	Reactome: R-HSA-1483148;Reactome: R-HSA-1483166	"Synthesis of PG";"Synthesis of PA"
XP_046429489.1	5	KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16;Reactome: R-HSA-5687128;KEGG: 05235+3.1.3.16;Reactome: R-HSA-176407	"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation";"MAPK6/MAPK4 signaling";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase"
XP_046422646.1	1	Reactome: R-HSA-2022377	"Metabolism of Angiotensinogen to Angiotensins"
XP_046428735.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_046412124.1	13	Reactome: R-HSA-975957;Reactome: R-HSA-6791226;Reactome: R-HSA-975956;Reactome: R-HSA-156902;Reactome: R-HSA-72764;Reactome: R-HSA-9633012;Reactome: R-HSA-72689;Reactome: R-HSA-192823;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-2408557;Reactome: R-HSA-72706;Reactome: R-HSA-1799339	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Peptide chain elongation";"Eukaryotic Translation Termination";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Formation of a pool of free 40S subunits";"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Selenocysteine synthesis";"GTP hydrolysis and joining of the 60S ribosomal subunit";"SRP-dependent cotranslational protein targeting to membrane"
XP_046420476.1	2	Reactome: R-HSA-975577;Reactome: R-HSA-2022854	"N-Glycan antennae elongation";"Keratan sulfate biosynthesis"
XP_046419651.1	1	Reactome: R-HSA-5689880	"Ub-specific processing proteases"
XP_046427265.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046433555.1	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_046434881.1	2	Reactome: R-HSA-444821;Reactome: R-HSA-418555	"Relaxin receptors";"G alpha (s) signalling events"
XP_046435307.1	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
XP_046416511.1	5	Reactome: R-HSA-73817;KEGG: 00230+6.3.2.6;MetaCyc: PWY-6124;MetaCyc: PWY-6123;MetaCyc: PWY-7234	"Purine ribonucleoside monophosphate biosynthesis";"Purine metabolism";"Inosine-5'-phosphate biosynthesis II";"Inosine-5'-phosphate biosynthesis I";"Inosine-5'-phosphate biosynthesis III"
XP_046411765.1	4	Reactome: R-HSA-983712;Reactome: R-HSA-917977;Reactome: R-HSA-1222556;Reactome: R-HSA-77387	"Ion channel transport";"Transferrin endocytosis and recycling";"ROS and RNS production in phagocytes";"Insulin receptor recycling"
XP_046429082.1	19	Reactome: R-HSA-8856825;Reactome: R-HSA-8964026;Reactome: R-HSA-8963901;Reactome: R-HSA-8964038;Reactome: R-HSA-8957275;Reactome: R-HSA-8856828;Reactome: R-HSA-432142;Reactome: R-HSA-8964041;Reactome: R-HSA-3000484;Reactome: R-HSA-381426;Reactome: R-HSA-8963888;Reactome: R-HSA-8866423;Reactome: R-HSA-3000497;Reactome: R-HSA-3000480;Reactome: R-HSA-202733;Reactome: R-HSA-8964046;Reactome: R-HSA-3000471;Reactome: R-HSA-5686938;Reactome: R-HSA-975634	"Cargo recognition for clathrin-mediated endocytosis";"Chylomicron clearance";"Chylomicron remodeling";"LDL clearance";"Post-translational protein phosphorylation";"Clathrin-mediated endocytosis";"Platelet sensitization by LDL";"LDL remodeling";"Scavenging by Class F Receptors";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"Chylomicron assembly";"VLDL assembly";"Scavenging by Class H Receptors";"Scavenging by Class A Receptors";"Cell surface interactions at the vascular wall";"VLDL clearance";"Scavenging by Class B Receptors";"Regulation of TLR by endogenous ligand";"Retinoid metabolism and transport"
XP_046428742.1	2	Reactome: R-HSA-983168;Reactome: R-HSA-8951664	"Antigen processing: Ubiquitination & Proteasome degradation";"Neddylation"
XP_046422602.1	8	KEGG: 00052+2.7.1.1;KEGG: 00500+2.7.1.1;KEGG: 00521+2.7.1.1;KEGG: 00520+2.7.1.1;KEGG: 00051+2.7.1.1;KEGG: 00010+2.7.1.1;Reactome: R-HSA-70171;KEGG: 00524+2.7.1.1	"Galactose metabolism";"Starch and sucrose metabolism";"Streptomycin biosynthesis";"Amino sugar and nucleotide sugar metabolism";"Fructose and mannose metabolism";"Glycolysis / Gluconeogenesis";"Glycolysis";"Neomycin, kanamycin and gentamicin biosynthesis"
XP_046430723.1	1	Reactome: R-HSA-156842	"Eukaryotic Translation Elongation"
XP_046425347.1	1	Reactome: R-HSA-390648	"Muscarinic acetylcholine receptors"
XP_046434849.1	56	Reactome: R-HSA-5610783;Reactome: R-HSA-8852276;Reactome: R-HSA-69481;Reactome: R-HSA-8948751;Reactome: R-HSA-1234176;Reactome: R-HSA-187577;Reactome: R-HSA-180534;Reactome: R-HSA-5607764;Reactome: R-HSA-68827;Reactome: R-HSA-5689603;Reactome: R-HSA-5687128;Reactome: R-HSA-174113;Reactome: R-HSA-9020702;Reactome: R-HSA-8854050;Reactome: R-HSA-195253;Reactome: R-HSA-2871837;Reactome: R-HSA-174178;Reactome: R-HSA-68949;Reactome: R-HSA-382556;Reactome: R-HSA-1169091;Reactome: R-HSA-5676590;Reactome: R-HSA-5362768;Reactome: R-HSA-9604323;Reactome: R-HSA-69017;Reactome: R-HSA-69601;Reactome: R-HSA-5358346;Reactome: R-HSA-9010553;Reactome: R-HSA-8941858;Reactome: R-HSA-350562;Reactome: R-HSA-5668541;Reactome: R-HSA-4641258;Reactome: R-HSA-211733;Reactome: R-HSA-5632684;Reactome: R-HSA-5610780;Reactome: R-HSA-450408;Reactome: R-HSA-1236974;Reactome: R-HSA-8939236;Reactome: R-HSA-5610785;Reactome: R-HSA-180585;Reactome: R-HSA-5678895;Reactome: R-HSA-202424;Reactome: R-HSA-75815;Reactome: R-HSA-4641257;Reactome: R-HSA-4608870;Reactome: R-HSA-1236978;Reactome: R-HSA-349425;Reactome: R-HSA-5689880;Reactome: R-HSA-8951664;Reactome: R-HSA-174084;Reactome: R-HSA-2467813;Reactome: R-HSA-8939902;Reactome: R-HSA-174184;Reactome: R-HSA-174154;Reactome: R-HSA-983168;Reactome: R-HSA-5658442;Reactome: R-HSA-5607761	"Degradation of GLI2 by the proteasome";"The role of GTSE1 in G2/M progression after G2 checkpoint";"G2/M Checkpoints";"Regulation of PTEN stability and activity";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"SCF(Skp2)-mediated degradation of p27/p21";"Vpu mediated degradation of CD4";"CLEC7A (Dectin-1) signaling";"CDT1 association with the CDC6:ORC:origin complex";"UCH proteinases";"MAPK6/MAPK4 signaling";"SCF-beta-TrCP mediated degradation of Emi1";"Interleukin-1 signaling";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Degradation of beta-catenin by the destruction complex";"FCERI mediated NF-kB activation";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Orc1 removal from chromatin";"ABC-family proteins mediated transport";"Activation of NF-kappaB in B cells";"NIK-->noncanonical NF-kB signaling";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Negative regulation of NOTCH4 signaling";"CDK-mediated phosphorylation and removal of Cdc6";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Hedgehog ligand biogenesis";"Regulation of expression of SLITs and ROBOs";"Regulation of RUNX3 expression and activity";"Regulation of ornithine decarboxylase (ODC)";"TNFR2 non-canonical NF-kB pathway";"Degradation of DVL";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Hedgehog 'on' state";"Degradation of GLI1 by the proteasome";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"ER-Phagosome pathway";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"GLI3 is processed to GLI3R by the proteasome";"Vif-mediated degradation of APOBEC3G";"Defective CFTR causes cystic fibrosis";"Downstream TCR signaling";"Ubiquitin-dependent degradation of Cyclin D";"Degradation of AXIN";"Asymmetric localization of PCP proteins";"Cross-presentation of soluble exogenous antigens (endosomes)";"Autodegradation of the E3 ubiquitin ligase COP1";"Ub-specific processing proteases";"Neddylation";"Autodegradation of Cdh1 by Cdh1:APC/C";"Separation of Sister Chromatids";"Regulation of RUNX2 expression and activity";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"APC/C:Cdc20 mediated degradation of Securin";"Antigen processing: Ubiquitination & Proteasome degradation";"Regulation of RAS by GAPs";"Dectin-1 mediated noncanonical NF-kB signaling"
XP_046413430.1	11	Reactome: R-HSA-5673001;Reactome: R-HSA-1227986;Reactome: R-HSA-8847993;Reactome: R-HSA-1257604;Reactome: R-HSA-9664565;Reactome: R-HSA-2219530;Reactome: R-HSA-6785631;Reactome: R-HSA-6811558;Reactome: R-HSA-8863795;Reactome: R-HSA-1963642;Reactome: R-HSA-1250196	"RAF/MAP kinase cascade";"Signaling by ERBB2";"ERBB2 Activates PTK6 Signaling";"PIP3 activates AKT signaling";"Signaling by ERBB2 KD Mutants";"Constitutive Signaling by Aberrant PI3K in Cancer";"ERBB2 Regulates Cell Motility";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"Downregulation of ERBB2 signaling";"PI3K events in ERBB2 signaling";"SHC1 events in ERBB2 signaling"
XP_046419332.1	4	Reactome: R-HSA-8856828;Reactome: R-HSA-6794361;Reactome: R-HSA-5250958;Reactome: R-HSA-8856825	"Clathrin-mediated endocytosis";"Neurexins and neuroligins";"Toxicity of botulinum toxin type B (BoNT/B)";"Cargo recognition for clathrin-mediated endocytosis"
XP_046425176.1	1	Reactome: R-HSA-4615885	"SUMOylation of DNA replication proteins"
XP_046423383.1	3	Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-212436	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"Generic Transcription Pathway"
XP_046433124.1	7	Reactome: R-HSA-9018519;Reactome: R-HSA-1221632;Reactome: R-HSA-2468052;Reactome: R-HSA-3108214;Reactome: R-HSA-2467813;Reactome: R-HSA-2470946;Reactome: R-HSA-2500257	"Estrogen-dependent gene expression";"Meiotic synapsis";"Establishment of Sister Chromatid Cohesion";"SUMOylation of DNA damage response and repair proteins";"Separation of Sister Chromatids";"Cohesin Loading onto Chromatin";"Resolution of Sister Chromatid Cohesion"
XP_046423471.1	2	Reactome: R-HSA-804914;Reactome: R-HSA-9029569	"Transport of fatty acids";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux"
XP_046413789.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046411281.1	4	Reactome: R-HSA-2408522;Reactome: R-HSA-379726;KEGG: 00970+6.1.1.6;Reactome: R-HSA-379716	"Selenoamino acid metabolism";"Mitochondrial tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis";"Cytosolic tRNA aminoacylation"
XP_046433991.1	14	MetaCyc: PWY-6433;MetaCyc: PWY-7724;Reactome: R-HSA-75876;MetaCyc: PWY-5972;MetaCyc: PWY-5080;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7601;MetaCyc: PWY-7619;MetaCyc: PWY-7725;MetaCyc: PWY-7035;MetaCyc: PWY-8041;MetaCyc: PWY-6598;MetaCyc: PWY-7036;MetaCyc: PWY-7602	"Hydroxylated fatty acid biosynthesis (plants)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Synthesis of very long-chain fatty acyl-CoAs";"Stearate biosynthesis I (animals)";"Very long chain fatty acid biosynthesis I";"Fatty acid elongation";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Juniperonate biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"(9Z)-tricosene biosynthesis";"Ultra-long-chain fatty acid biosynthesis";"Sciadonate biosynthesis";"Very long chain fatty acid biosynthesis II";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)"
XP_046418452.1	4	Reactome: R-HSA-76071;Reactome: R-HSA-749476;Reactome: R-HSA-76066;Reactome: R-HSA-76061	"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Transcription Initiation From Type 1 Promoter"
XP_046410283.1	2	Reactome: R-HSA-429947;Reactome: R-HSA-6804115	"Deadenylation of mRNA";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"
XP_046421245.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046432152.1	1	Reactome: R-HSA-390522	"Striated Muscle Contraction"
XP_046424011.1	1	Reactome: R-HSA-8873719	"RAB geranylgeranylation"
XP_046420055.1	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
XP_046436566.1	9	Reactome: R-HSA-3304356;Reactome: R-HSA-3656535;Reactome: R-HSA-3642279;Reactome: R-HSA-2173788;Reactome: R-HSA-3645790;Reactome: R-HSA-5689603;Reactome: R-HSA-2173789;Reactome: R-HSA-2173791;Reactome: R-HSA-3656532	"SMAD2/3 Phosphorylation Motif Mutants in Cancer";"TGFBR1 LBD Mutants in Cancer";"TGFBR2 MSI Frameshift Mutants in Cancer";"Downregulation of TGF-beta receptor signaling";"TGFBR2 Kinase Domain Mutants in Cancer";"UCH proteinases";"TGF-beta receptor signaling activates SMADs";"TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)";"TGFBR1 KD Mutants in Cancer"
XP_046419130.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_046409726.1	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
XP_046412645.1	4	Reactome: R-HSA-2894862;Reactome: R-HSA-2122947;Reactome: R-HSA-2644606;Reactome: R-HSA-350054	"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"NOTCH1 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Notch-HLH transcription pathway"
XP_046432680.1	3	KEGG: 00270+5.3.1.23;MetaCyc: PWY-4361;MetaCyc: PWY-7174	"Cysteine and methionine metabolism";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation II"
XP_046419752.1	6	MetaCyc: PWY-6722;Reactome: R-HSA-196780;MetaCyc: PWY-5744;MetaCyc: PWY-5743;MetaCyc: PWY-5789;MetaCyc: PWY-4381	"Candicidin biosynthesis";"Biotin transport and metabolism";"Glyoxylate assimilation";"3-hydroxypropanoate cycle";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Fatty acid biosynthesis initiation (bacteria and plants)"
XP_046423952.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_046421960.1	2	Reactome: R-HSA-1296052;Reactome: R-HSA-418457	"Ca2+ activated K+ channels";"cGMP effects"
XP_046424981.1	11	Reactome: R-HSA-170670;KEGG: 00230+4.6.1.1;Reactome: R-HSA-5610787;Reactome: R-HSA-163615;Reactome: R-HSA-432040;Reactome: R-HSA-418594;Reactome: R-HSA-170660;Reactome: R-HSA-418597;Reactome: R-HSA-418555;Reactome: R-HSA-163359;Reactome: R-HSA-164378	"Adenylate cyclase inhibitory pathway";"Purine metabolism";"Hedgehog 'off' state";"PKA activation";"Vasopressin regulates renal water homeostasis via Aquaporins";"G alpha (i) signalling events";"Adenylate cyclase activating pathway";"G alpha (z) signalling events";"G alpha (s) signalling events";"Glucagon signaling in metabolic regulation";"PKA activation in glucagon signalling"
XP_046428842.1	1	Reactome: R-HSA-6799198	"Complex I biogenesis"
XP_046424498.1	5	Reactome: R-HSA-6811438;Reactome: R-HSA-6811434;Reactome: R-HSA-204005;Reactome: R-HSA-6807878;Reactome: R-HSA-6811440	"Intra-Golgi traffic";"COPI-dependent Golgi-to-ER retrograde traffic";"COPII-mediated vesicle transport";"COPI-mediated anterograde transport";"Retrograde transport at the Trans-Golgi-Network"
XP_046416520.1	1	Reactome: R-HSA-5649702	"APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway"
XP_046423269.1	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
XP_046419250.1	1	Reactome: R-HSA-352230	"Amino acid transport across the plasma membrane"
XP_046432186.1	1	Reactome: R-HSA-1296052	"Ca2+ activated K+ channels"
XP_046421356.1	1	Reactome: R-HSA-9037629	"Lewis blood group biosynthesis"
XP_046426943.1	2	Reactome: R-HSA-427413;Reactome: R-HSA-3214815	"NoRC negatively regulates rRNA expression";"HDACs deacetylate histones"
XP_046414639.1	14	MetaCyc: PWY-8051;MetaCyc: PWY-6453;KEGG: 00564+2.3.1.51;MetaCyc: PWY-8055;KEGG: 00561+2.3.1.51;MetaCyc: PWY-5667;Reactome: R-HSA-1483166;MetaCyc: PWY-7411;MetaCyc: PWY-7587;MetaCyc: PWY-7782;MetaCyc: PWY-7589;MetaCyc: PWY-5981;MetaCyc: PWY-8053;MetaCyc: PWY-7417	"Anandamide biosynthesis I";"Stigma estolide biosynthesis";"Glycerophospholipid metabolism";"Palmitoyl ethanolamide biosynthesis";"Glycerolipid metabolism";"CDP-diacylglycerol biosynthesis I";"Synthesis of PA";"Phosphatidate biosynthesis (yeast)";"Oleate biosynthesis III (cyanobacteria)";"Plasmalogen biosynthesis";"Palmitoleate biosynthesis III (cyanobacteria)";"CDP-diacylglycerol biosynthesis III";"Anandamide biosynthesis II";"Phospholipid remodeling (phosphatidate, yeast)"
XP_046416851.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_046418117.1	6	KEGG: 00531+3.2.1.23;KEGG: 00511+3.2.1.23;KEGG: 00600+3.2.1.23;MetaCyc: PWY-6807;KEGG: 00604+3.2.1.23;KEGG: 00052+3.2.1.23	"Glycosaminoglycan degradation";"Other glycan degradation";"Sphingolipid metabolism";"Xyloglucan degradation II (exoglucanase)";"Glycosphingolipid biosynthesis - ganglio series";"Galactose metabolism"
XP_046417351.1	8	Reactome: R-HSA-1445148;Reactome: R-HSA-380972;Reactome: R-HSA-2151209;Reactome: R-HSA-9619483;Reactome: R-HSA-1632852;Reactome: R-HSA-9613354;Reactome: R-HSA-5628897;Reactome: R-HSA-6804756	"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Energy dependent regulation of mTOR by LKB1-AMPK";"Activation of PPARGC1A (PGC-1alpha) by phosphorylation";"Activation of AMPK downstream of NMDARs";"Macroautophagy";"Lipophagy";"TP53 Regulates Metabolic Genes";"Regulation of TP53 Activity through Phosphorylation"
XP_046427514.1	2	KEGG: 00510+2.4.1.256;Reactome: R-HSA-446193	"N-Glycan biosynthesis";"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein"
XP_046430053.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046416457.1	31	MetaCyc: PWY-5366;MetaCyc: PWY-7858;Reactome: R-HSA-9029558;MetaCyc: PWY-5147;MetaCyc: PWY-7723;MetaCyc: PWY-5989;MetaCyc: PWY-7746;KEGG: 00061+1.1.1.100+2.3.1.85+4.2.1.59+2.3.1.39+2.3.1.41+3.1.2.14;MetaCyc: PWY-8047;MetaCyc: PWY-5973;MetaCyc: PWY-6282;Reactome: R-HSA-75105;MetaCyc: PWY-7663;MetaCyc: PWY-6519;Reactome: R-HSA-163765;MetaCyc: PWY-5971;MetaCyc: PWY-5994;MetaCyc: PWY-6113;MetaCyc: PWY-7388;MetaCyc: PWY-5966-1;MetaCyc: PWY-6799;MetaCyc: PWY-4381;MetaCyc: PWY-8012;MetaCyc: PWY-8049;MetaCyc: PWYG-321;Reactome: R-HSA-199220;Reactome: R-HSA-2426168;MetaCyc: PWY-5142;MetaCyc: PWY-7664;KEGG: 00780+1.1.1.100+4.2.1.59+2.3.1.41;MetaCyc: PWY-5367	"Palmitoleate biosynthesis II (plants and bacteria)";"(5Z)-dodecenoate biosynthesis II";"NR1H2 & NR1H3 regulate gene expression linked to lipogenesis";"Oleate biosynthesis I (plants)";"Bacterial bioluminescence";"Stearate biosynthesis II (bacteria and plants)";"Mycobacterial sulfolipid biosynthesis";"Fatty acid biosynthesis";"Bryostatin biosynthesis";"Cis-vaccenate biosynthesis";"Palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate)";"Fatty acyl-CoA biosynthesis";"Gondoate biosynthesis (anaerobic)";"8-amino-7-oxononanoate biosynthesis I";"ChREBP activates metabolic gene expression";"Palmitate biosynthesis II (bacteria and plant cytoplasm)";"Palmitate biosynthesis (animals and fungi, cytoplasm)";"Superpathway of mycolate biosynthesis";"Octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast)";"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)";"Fatty acid biosynthesis initiation (plant mitochondria)";"Fatty acid biosynthesis initiation (bacteria and plants)";"Mupirocin biosynthesis";"Pederin biosynthesis";"";"Vitamin B5 (pantothenate) metabolism";"Activation of gene expression by SREBF (SREBP)";"Acyl-[acyl-carrier protein] thioesterase pathway";"Oleate biosynthesis IV (anaerobic)";"Biotin metabolism";"Petroselinate biosynthesis"
XP_046425242.1	57	Reactome: R-HSA-5658442;Reactome: R-HSA-983168;Reactome: R-HSA-5607761;Reactome: R-HSA-6798695;Reactome: R-HSA-8939902;Reactome: R-HSA-174184;Reactome: R-HSA-174154;Reactome: R-HSA-2467813;Reactome: R-HSA-349425;Reactome: R-HSA-174084;Reactome: R-HSA-8951664;Reactome: R-HSA-5689880;Reactome: R-HSA-75815;Reactome: R-HSA-202424;Reactome: R-HSA-4608870;Reactome: R-HSA-4641257;Reactome: R-HSA-1236978;Reactome: R-HSA-5610785;Reactome: R-HSA-5678895;Reactome: R-HSA-180585;Reactome: R-HSA-8939236;Reactome: R-HSA-211733;Reactome: R-HSA-4641258;Reactome: R-HSA-5632684;Reactome: R-HSA-5610780;Reactome: R-HSA-450408;Reactome: R-HSA-1236974;Reactome: R-HSA-8941858;Reactome: R-HSA-350562;Reactome: R-HSA-9010553;Reactome: R-HSA-5668541;Reactome: R-HSA-5676590;Reactome: R-HSA-5362768;Reactome: R-HSA-9604323;Reactome: R-HSA-69017;Reactome: R-HSA-5358346;Reactome: R-HSA-69601;Reactome: R-HSA-195253;Reactome: R-HSA-174178;Reactome: R-HSA-2871837;Reactome: R-HSA-1169091;Reactome: R-HSA-68949;Reactome: R-HSA-382556;Reactome: R-HSA-9020702;Reactome: R-HSA-8854050;Reactome: R-HSA-5687128;Reactome: R-HSA-174113;Reactome: R-HSA-187577;Reactome: R-HSA-180534;Reactome: R-HSA-5607764;Reactome: R-HSA-68827;Reactome: R-HSA-5689603;Reactome: R-HSA-5610783;Reactome: R-HSA-8852276;Reactome: R-HSA-69481;Reactome: R-HSA-1234176;Reactome: R-HSA-8948751	"Regulation of RAS by GAPs";"Antigen processing: Ubiquitination & Proteasome degradation";"Dectin-1 mediated noncanonical NF-kB signaling";"Neutrophil degranulation";"Regulation of RUNX2 expression and activity";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"APC/C:Cdc20 mediated degradation of Securin";"Separation of Sister Chromatids";"Autodegradation of the E3 ubiquitin ligase COP1";"Autodegradation of Cdh1 by Cdh1:APC/C";"Neddylation";"Ub-specific processing proteases";"Ubiquitin-dependent degradation of Cyclin D";"Downstream TCR signaling";"Asymmetric localization of PCP proteins";"Degradation of AXIN";"Cross-presentation of soluble exogenous antigens (endosomes)";"GLI3 is processed to GLI3R by the proteasome";"Defective CFTR causes cystic fibrosis";"Vif-mediated degradation of APOBEC3G";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Degradation of DVL";"Hedgehog 'on' state";"Degradation of GLI1 by the proteasome";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"ER-Phagosome pathway";"Regulation of RUNX3 expression and activity";"Regulation of ornithine decarboxylase (ODC)";"Regulation of expression of SLITs and ROBOs";"TNFR2 non-canonical NF-kB pathway";"NIK-->noncanonical NF-kB signaling";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Negative regulation of NOTCH4 signaling";"CDK-mediated phosphorylation and removal of Cdc6";"Hedgehog ligand biogenesis";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Degradation of beta-catenin by the destruction complex";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"FCERI mediated NF-kB activation";"Activation of NF-kappaB in B cells";"Orc1 removal from chromatin";"ABC-family proteins mediated transport";"Interleukin-1 signaling";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"MAPK6/MAPK4 signaling";"SCF-beta-TrCP mediated degradation of Emi1";"SCF(Skp2)-mediated degradation of p27/p21";"Vpu mediated degradation of CD4";"CLEC7A (Dectin-1) signaling";"CDT1 association with the CDC6:ORC:origin complex";"UCH proteinases";"Degradation of GLI2 by the proteasome";"The role of GTSE1 in G2/M progression after G2 checkpoint";"G2/M Checkpoints";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of PTEN stability and activity"
XP_046413971.1	1	Reactome: R-HSA-112308	"Presynaptic depolarization and calcium channel opening"
XP_046430833.1	2	Reactome: R-HSA-1236394;Reactome: R-HSA-977443	"Signaling by ERBB4";"GABA receptor activation"
XP_046425971.1	1	Reactome: R-HSA-3214842	"HDMs demethylate histones"
XP_046411851.1	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
XP_046421976.1	2	Reactome: R-HSA-1296052;Reactome: R-HSA-418457	"Ca2+ activated K+ channels";"cGMP effects"
XP_046435898.1	1	Reactome: R-HSA-8963901	"Chylomicron remodeling"
XP_046426911.1	1	Reactome: R-HSA-3238698	"WNT ligand biogenesis and trafficking"
XP_046423326.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046413082.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046413019.1	1	Reactome: R-HSA-83936	"Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"
XP_046432696.1	1	Reactome: R-HSA-381753	"Olfactory Signaling Pathway"
XP_046431513.1	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
XP_046419494.1	3	Reactome: R-HSA-8874081;Reactome: R-HSA-3000171;Reactome: R-HSA-3000157	"MET activates PTK2 signaling";"Non-integrin membrane-ECM interactions";"Laminin interactions"
XP_046428532.1	2	KEGG: 00670+2.1.2.10;KEGG: 00260+2.1.2.10	"One carbon pool by folate";"Glycine, serine and threonine metabolism"
XP_046415204.1	2	KEGG: 00230+2.7.4.8;MetaCyc: PWY-7221	"Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis"
XP_046416283.1	17	Reactome: R-HSA-5656169;Reactome: R-HSA-5696397;Reactome: R-HSA-110314;Reactome: R-HSA-69091;Reactome: R-HSA-5696400;Reactome: R-HSA-5358565;Reactome: R-HSA-6782135;Reactome: R-HSA-5651801;Reactome: R-HSA-69166;Reactome: R-HSA-69183;Reactome: R-HSA-174414;Reactome: R-HSA-174411;Reactome: R-HSA-174417;Reactome: R-HSA-5685942;Reactome: R-HSA-5358606;Reactome: R-HSA-174437;Reactome: R-HSA-6782210	"Termination of translesion DNA synthesis";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Recognition of DNA damage by PCNA-containing replication complex";"Polymerase switching";"Dual Incision in GG-NER";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"Dual incision in TC-NER";"PCNA-Dependent Long Patch Base Excision Repair";"Removal of the Flap Intermediate";"Processive synthesis on the lagging strand";"Processive synthesis on the C-strand of the telomere";"Polymerase switching on the C-strand of the telomere";"Telomere C-strand (Lagging Strand) Synthesis";"HDR through Homologous Recombination (HRR)";"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"Removal of the Flap Intermediate from the C-strand";"Gap-filling DNA repair synthesis and ligation in TC-NER"
XP_046419116.1	1	Reactome: R-HSA-382556	"ABC-family proteins mediated transport"
XP_046424041.1	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046429437.1	1	Reactome: R-HSA-1632852	"Macroautophagy"
XP_046409738.1	9	Reactome: R-HSA-76042;Reactome: R-HSA-75953;Reactome: R-HSA-167172;Reactome: R-HSA-167162;Reactome: R-HSA-6804756;Reactome: R-HSA-167161;Reactome: R-HSA-674695;Reactome: R-HSA-73776;Reactome: R-HSA-73779	"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II Transcription Initiation";"Transcription of the HIV genome";"RNA Polymerase II HIV Promoter Escape";"Regulation of TP53 Activity through Phosphorylation";"HIV Transcription Initiation";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"
XP_046436296.1	7	Reactome: R-HSA-380320;Reactome: R-HSA-2565942;Reactome: R-HSA-380270;Reactome: R-HSA-8854518;Reactome: R-HSA-380259;Reactome: R-HSA-380284;Reactome: R-HSA-5620912	"Recruitment of NuMA to mitotic centrosomes";"Regulation of PLK1 Activity at G2/M Transition";"Recruitment of mitotic centrosome proteins and complexes";"AURKA Activation by TPX2";"Loss of Nlp from mitotic centrosomes";"Loss of proteins required for interphase microtubule organization from the centrosome";"Anchoring of the basal body to the plasma membrane"
XP_046424649.1	6	KEGG: 00511+3.2.1.23;KEGG: 00600+3.2.1.23;KEGG: 00531+3.2.1.23;KEGG: 00052+3.2.1.23;KEGG: 00604+3.2.1.23;MetaCyc: PWY-6807	"Other glycan degradation";"Sphingolipid metabolism";"Glycosaminoglycan degradation";"Galactose metabolism";"Glycosphingolipid biosynthesis - ganglio series";"Xyloglucan degradation II (exoglucanase)"
XP_046428521.1	2	KEGG: 00670+2.1.2.10;KEGG: 00260+2.1.2.10	"One carbon pool by folate";"Glycine, serine and threonine metabolism"
XP_046418669.1	2	Reactome: R-HSA-1989781;Reactome: R-HSA-381340	"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation"
XP_046416352.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046412949.1	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
XP_046424020.1	8	KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;Reactome: R-HSA-428540;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1	"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Thermogenesis";"Relaxin signaling pathway";"Human cytomegalovirus infection";"Activation of RAC1";"PI3K-Akt signaling pathway";"mTOR signaling pathway"
XP_046418483.1	1	Reactome: R-HSA-8854214	"TBC/RABGAPs"
XP_046430618.1	3	Reactome: R-HSA-6798695;Reactome: R-HSA-202427;Reactome: R-HSA-6807004	"Neutrophil degranulation";"Phosphorylation of CD3 and TCR zeta chains";"Negative regulation of MET activity"
XP_046420009.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
XP_046415307.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046419178.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046428379.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
XP_046429678.1	15	Reactome: R-HSA-9029569;Reactome: R-HSA-2559580;Reactome: R-HSA-9022692;Reactome: R-HSA-8853884;Reactome: R-HSA-5687128;Reactome: R-HSA-8943723;Reactome: R-HSA-1912408;Reactome: R-HSA-4086398;Reactome: R-HSA-8986944;Reactome: R-HSA-2559585;Reactome: R-HSA-8948700;Reactome: R-HSA-5628897;Reactome: R-HSA-8934593;Reactome: R-HSA-9018519;Reactome: R-HSA-8936459	"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Oxidative Stress Induced Senescence";"Regulation of MECP2 expression and activity";"Transcriptional Regulation by VENTX";"MAPK6/MAPK4 signaling";"Regulation of PTEN mRNA translation";"Pre-NOTCH Transcription and Translation";"Ca2+ pathway";"Transcriptional Regulation by MECP2";"Oncogene Induced Senescence";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"TP53 Regulates Metabolic Genes";"Regulation of RUNX1 Expression and Activity";"Estrogen-dependent gene expression";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"
XP_046429757.1	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276	"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination"
XP_046426065.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
XP_046430995.1	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276	"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination"
XP_046434297.1	6	Reactome: R-HSA-975634;Reactome: R-HSA-3000171;Reactome: R-HSA-2453864;Reactome: R-HSA-977225;Reactome: R-HSA-2453902;Reactome: R-HSA-6798695	"Retinoid metabolism and transport";"Non-integrin membrane-ECM interactions";"Retinoid cycle disease events";"Amyloid fiber formation";"The canonical retinoid cycle in rods (twilight vision)";"Neutrophil degranulation"
XP_046424675.1	13	Reactome: R-HSA-72706;Reactome: R-HSA-2408557;Reactome: R-HSA-1799339;Reactome: R-HSA-9633012;Reactome: R-HSA-72689;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-192823;Reactome: R-HSA-156902;Reactome: R-HSA-975956;Reactome: R-HSA-72764;Reactome: R-HSA-975957;Reactome: R-HSA-6791226	"GTP hydrolysis and joining of the 60S ribosomal subunit";"Selenocysteine synthesis";"SRP-dependent cotranslational protein targeting to membrane";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Formation of a pool of free 40S subunits";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Viral mRNA Translation";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046410994.1	5	Reactome: R-HSA-1912399;Reactome: R-HSA-5083630;Reactome: R-HSA-350054;Reactome: R-HSA-1912420;Reactome: R-HSA-1912408	"Pre-NOTCH Processing in the Endoplasmic Reticulum";"Defective LFNG causes SCDO3";"Notch-HLH transcription pathway";"Pre-NOTCH Processing in Golgi";"Pre-NOTCH Transcription and Translation"
XP_046412590.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046432702.1	1	Reactome: R-HSA-381753	"Olfactory Signaling Pathway"
XP_046436313.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_046428823.1	3	MetaCyc: PWY-4041;KEGG: 00480+4.3.2.9;Reactome: R-HSA-174403	"Gamma-glutamyl cycle";"Glutathione metabolism";"Glutathione synthesis and recycling"
XP_046429676.1	15	Reactome: R-HSA-8853884;Reactome: R-HSA-5687128;Reactome: R-HSA-9022692;Reactome: R-HSA-9029569;Reactome: R-HSA-2559580;Reactome: R-HSA-8936459;Reactome: R-HSA-9018519;Reactome: R-HSA-8934593;Reactome: R-HSA-2559585;Reactome: R-HSA-5628897;Reactome: R-HSA-8948700;Reactome: R-HSA-8943723;Reactome: R-HSA-1912408;Reactome: R-HSA-4086398;Reactome: R-HSA-8986944	"Transcriptional Regulation by VENTX";"MAPK6/MAPK4 signaling";"Regulation of MECP2 expression and activity";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Oxidative Stress Induced Senescence";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Estrogen-dependent gene expression";"Regulation of RUNX1 Expression and Activity";"Oncogene Induced Senescence";"TP53 Regulates Metabolic Genes";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"Regulation of PTEN mRNA translation";"Pre-NOTCH Transcription and Translation";"Ca2+ pathway";"Transcriptional Regulation by MECP2"
XP_046427188.1	11	KEGG: 04714+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;Reactome: R-HSA-2559580;Reactome: R-HSA-171007;Reactome: R-HSA-4420097;KEGG: 05163+2.7.11.1;Reactome: R-HSA-450302;KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1	"Thermogenesis";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Oxidative Stress Induced Senescence";"p38MAPK events";"VEGFA-VEGFR2 Pathway";"Human cytomegalovirus infection";"activated TAK1 mediates p38 MAPK activation";"Relaxin signaling pathway";"PI3K-Akt signaling pathway";"mTOR signaling pathway"
XP_046411351.1	3	Reactome: R-HSA-191859;Reactome: R-HSA-72163;Reactome: R-HSA-72165	"snRNP Assembly";"mRNA Splicing - Major Pathway";"mRNA Splicing - Minor Pathway"
XP_046424797.1	7	Reactome: R-HSA-380284;Reactome: R-HSA-5620912;Reactome: R-HSA-380270;Reactome: R-HSA-2565942;Reactome: R-HSA-380320;Reactome: R-HSA-380259;Reactome: R-HSA-8854518	"Loss of proteins required for interphase microtubule organization from the centrosome";"Anchoring of the basal body to the plasma membrane";"Recruitment of mitotic centrosome proteins and complexes";"Regulation of PLK1 Activity at G2/M Transition";"Recruitment of NuMA to mitotic centrosomes";"Loss of Nlp from mitotic centrosomes";"AURKA Activation by TPX2"
XP_046425773.1	1	Reactome: R-HSA-211981	"Xenobiotics"
XP_046426500.1	7	KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1	"Human cytomegalovirus infection";"Thermogenesis";"Relaxin signaling pathway";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"PI3K-Akt signaling pathway";"mTOR signaling pathway"
XP_046432948.1	4	Reactome: R-HSA-8949613;Reactome: R-HSA-8950505;Reactome: R-HSA-3371453;Reactome: R-HSA-1268020	"Cristae formation";"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation";"Regulation of HSF1-mediated heat shock response";"Mitochondrial protein import"
XP_046425202.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046432474.1	6	Reactome: R-HSA-163560;KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;Reactome: R-HSA-400253;KEGG: 04658+3.1.3.16;Reactome: R-HSA-2173788	"Triglyceride catabolism";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"Circadian Clock";"Th1 and Th2 cell differentiation";"Downregulation of TGF-beta receptor signaling"
XP_046433001.1	5	Reactome: R-HSA-6798695;Reactome: R-HSA-1834949;Reactome: R-HSA-5693571;Reactome: R-HSA-164843;Reactome: R-HSA-3270619	"Neutrophil degranulation";"Cytosolic sensors of pathogen-associated DNA";"Nonhomologous End-Joining (NHEJ)";"2-LTR circle formation";"IRF3-mediated induction of type I IFN"
XP_046422614.1	3	MetaCyc: PWY-5067;KEGG: 00500+2.4.1.11;Reactome: R-HSA-3322077	"Glycogen biosynthesis II (from UDP-D-Glucose)";"Starch and sucrose metabolism";"Glycogen synthesis"
XP_046433247.1	1	Reactome: R-HSA-3295583	"TRP channels"
XP_046410739.1	4	Reactome: R-HSA-5576892;Reactome: R-HSA-419037;Reactome: R-HSA-5576893;Reactome: R-HSA-112308	"Phase 0 - rapid depolarisation";"NCAM1 interactions";"Phase 2 - plateau phase";"Presynaptic depolarization and calcium channel opening"
XP_046423738.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046428422.1	7	KEGG: 04926+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1	"Relaxin signaling pathway";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Human cytomegalovirus infection";"Thermogenesis";"PI3K-Akt signaling pathway";"mTOR signaling pathway"
XP_046414546.1	1	Reactome: R-HSA-5617833	"Cilium Assembly"
XP_046434424.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_046420861.1	33	Reactome: R-HSA-159227;Reactome: R-HSA-168333;Reactome: R-HSA-5663220;Reactome: R-HSA-5578749;Reactome: R-HSA-180746;Reactome: R-HSA-68877;Reactome: R-HSA-3301854;Reactome: R-HSA-6784531;Reactome: R-HSA-165054;Reactome: R-HSA-4085377;Reactome: R-HSA-170822;Reactome: R-HSA-180910;Reactome: R-HSA-141444;Reactome: R-HSA-159236;Reactome: R-HSA-168325;Reactome: R-HSA-9609690;Reactome: R-HSA-4570464;Reactome: R-HSA-168271;Reactome: R-HSA-191859;Reactome: R-HSA-159230;Reactome: R-HSA-4615885;Reactome: R-HSA-5619107;Reactome: R-HSA-168276;Reactome: R-HSA-4551638;Reactome: R-HSA-3232142;Reactome: R-HSA-3371453;Reactome: R-HSA-2500257;Reactome: R-HSA-9648025;Reactome: R-HSA-159231;Reactome: R-HSA-3108214;Reactome: R-HSA-1169408;Reactome: R-HSA-2467813;Reactome: R-HSA-9610379	"Transport of the SLBP independent Mature mRNA";"NEP/NS2 Interacts with the Cellular Export Machinery";"RHO GTPases Activate Formins";"Transcriptional regulation by small RNAs";"Nuclear import of Rev protein";"Mitotic Prometaphase";"Nuclear Pore Complex (NPC) Disassembly";"tRNA processing in the nucleus";"Rev-mediated nuclear export of HIV RNA";"SUMOylation of SUMOylation proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Vpr-mediated nuclear import of PICs";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Viral Messenger RNA Synthesis";"HCMV Early Events";"SUMOylation of RNA binding proteins";"Transport of Ribonucleoproteins into the Host Nucleus";"snRNP Assembly";"Transport of the SLBP Dependant Mature mRNA";"SUMOylation of DNA replication proteins";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"NS1 Mediated Effects on Host Pathways";"SUMOylation of chromatin organization proteins";"SUMOylation of ubiquitinylation proteins";"Regulation of HSF1-mediated heat shock response";"Resolution of Sister Chromatid Cohesion";"EML4 and NUDC in mitotic spindle formation";"Transport of Mature mRNA Derived from an Intronless Transcript";"SUMOylation of DNA damage response and repair proteins";"ISG15 antiviral mechanism";"Separation of Sister Chromatids";"HCMV Late Events"
XP_046431102.1	30	Reactome: R-HSA-8876198;Reactome: R-HSA-198693;KEGG: 05165+2.7.11.1;Reactome: R-HSA-5218920;Reactome: R-HSA-69202;Reactome: R-HSA-5674400;Reactome: R-HSA-6804759;Reactome: R-HSA-9634638;Reactome: R-HSA-69656;Reactome: R-HSA-392451;Reactome: R-HSA-8941332;Reactome: R-HSA-1257604;Reactome: R-HSA-6804757;Reactome: R-HSA-211163;Reactome: R-HSA-8948751;Reactome: R-HSA-1358803;Reactome: R-HSA-9614399;Reactome: R-HSA-199418;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;Reactome: R-HSA-389513;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;Reactome: R-HSA-389357;Reactome: R-HSA-6804758;Reactome: R-HSA-5628897;Reactome: R-HSA-111447;Reactome: R-HSA-198323;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1	"RAB GEFs exchange GTP for GDP on RABs";"AKT phosphorylates targets in the nucleus";"Human papillomavirus infection";"VEGFR2 mediated vascular permeability";"Cyclin E associated events during G1/S transition";"Constitutive Signaling by AKT1 E17K in Cancer";"Regulation of TP53 Activity through Association with Co-factors";"Estrogen-dependent nuclear events downstream of ESR-membrane signaling";"Cyclin A:Cdk2-associated events at S phase entry";"G beta:gamma signalling through PI3Kgamma";"RUNX2 regulates genes involved in cell migration";"PIP3 activates AKT signaling";"Regulation of TP53 Degradation";"AKT-mediated inactivation of FOXO1A";"Regulation of PTEN stability and activity";"Downregulation of ERBB2:ERBB3 signaling";"Regulation of localization of FOXO transcription factors";"Negative regulation of the PI3K/AKT network";"Thermogenesis";"Human immunodeficiency virus 1 infection";"CTLA4 inhibitory signaling";"Human cytomegalovirus infection";"Relaxin signaling pathway";"CD28 dependent PI3K/Akt signaling";"Regulation of TP53 Activity through Acetylation";"TP53 Regulates Metabolic Genes";"Activation of BAD and translocation to mitochondria";"AKT phosphorylates targets in the cytosol";"PI3K-Akt signaling pathway";"mTOR signaling pathway"
XP_046418664.1	27	Reactome: R-HSA-168333;Reactome: R-HSA-159227;Reactome: R-HSA-168271;Reactome: R-HSA-4615885;Reactome: R-HSA-159230;Reactome: R-HSA-180746;Reactome: R-HSA-5578749;Reactome: R-HSA-191859;Reactome: R-HSA-168276;Reactome: R-HSA-3301854;Reactome: R-HSA-5619107;Reactome: R-HSA-4551638;Reactome: R-HSA-165054;Reactome: R-HSA-4085377;Reactome: R-HSA-6784531;Reactome: R-HSA-180910;Reactome: R-HSA-3371453;Reactome: R-HSA-170822;Reactome: R-HSA-3232142;Reactome: R-HSA-9609690;Reactome: R-HSA-3108214;Reactome: R-HSA-159231;Reactome: R-HSA-1169408;Reactome: R-HSA-168325;Reactome: R-HSA-159236;Reactome: R-HSA-4570464;Reactome: R-HSA-9610379	"NEP/NS2 Interacts with the Cellular Export Machinery";"Transport of the SLBP independent Mature mRNA";"Transport of Ribonucleoproteins into the Host Nucleus";"SUMOylation of DNA replication proteins";"Transport of the SLBP Dependant Mature mRNA";"Nuclear import of Rev protein";"Transcriptional regulation by small RNAs";"snRNP Assembly";"NS1 Mediated Effects on Host Pathways";"Nuclear Pore Complex (NPC) Disassembly";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"SUMOylation of chromatin organization proteins";"Rev-mediated nuclear export of HIV RNA";"SUMOylation of SUMOylation proteins";"tRNA processing in the nucleus";"Vpr-mediated nuclear import of PICs";"Regulation of HSF1-mediated heat shock response";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"SUMOylation of ubiquitinylation proteins";"HCMV Early Events";"SUMOylation of DNA damage response and repair proteins";"Transport of Mature mRNA Derived from an Intronless Transcript";"ISG15 antiviral mechanism";"Viral Messenger RNA Synthesis";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"SUMOylation of RNA binding proteins";"HCMV Late Events"
XP_046422758.1	3	Reactome: R-HSA-8963684;Reactome: R-HSA-156590;Reactome: R-HSA-204174	"Tyrosine catabolism";"Glutathione conjugation";"Regulation of pyruvate dehydrogenase (PDH) complex"
XP_046431133.1	2	Reactome: R-HSA-445355;Reactome: R-HSA-390522	"Smooth Muscle Contraction";"Striated Muscle Contraction"
XP_046429191.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_046422413.1	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
XP_046419046.1	6	MetaCyc: PWY-5723;MetaCyc: PWY-1861;KEGG: 00030+5.1.3.1;Reactome: R-HSA-71336;KEGG: 00040+5.1.3.1;KEGG: 00710+5.1.3.1	"Rubisco shunt";"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"Pentose phosphate pathway";"Pentose phosphate pathway";"Pentose and glucuronate interconversions";"Carbon fixation in photosynthetic organisms"
XP_046425184.1	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
XP_046412471.1	1	KEGG: 00970+6.3.5.7	"Aminoacyl-tRNA biosynthesis"
XP_046410268.1	2	KEGG: 00620+3.1.2.6;MetaCyc: PWY-5386	"Pyruvate metabolism";"Methylglyoxal degradation I"
XP_046425787.1	2	Reactome: R-HSA-3299685;MetaCyc: PWY-6854	"Detoxification of Reactive Oxygen Species";"Ethylene biosynthesis III (microbes)"
XP_046418311.1	1	Reactome: R-HSA-1855231	"Synthesis of IPs in the ER lumen"
XP_046432698.1	1	Reactome: R-HSA-381753	"Olfactory Signaling Pathway"
XP_046421170.1	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046409500.1	1	Reactome: R-HSA-425366	"Transport of bile salts and organic acids, metal ions and amine compounds"
XP_046426585.1	2	KEGG: 00270+3.3.1.1;MetaCyc: PWY-5041	"Cysteine and methionine metabolism";"S-adenosyl-L-methionine cycle II"
XP_046419745.1	2	KEGG: 00563+2.4.1.198;Reactome: R-HSA-162710	"Glycosylphosphatidylinositol (GPI)-anchor biosynthesis";"Synthesis of glycosylphosphatidylinositol (GPI)"
XP_046421860.1	3	Reactome: R-HSA-5620916;Reactome: R-HSA-264876;Reactome: R-HSA-1445148	"VxPx cargo-targeting to cilium";"Insulin processing";"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
XP_046424872.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046432106.1	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
XP_046424841.1	3	Reactome: R-HSA-1442490;Reactome: R-HSA-1474228;Reactome: R-HSA-1592389	"Collagen degradation";"Degradation of the extracellular matrix";"Activation of Matrix Metalloproteinases"
XP_046410384.1	56	Reactome: R-HSA-5678895;Reactome: R-HSA-180585;Reactome: R-HSA-5610785;Reactome: R-HSA-8939236;Reactome: R-HSA-5689880;Reactome: R-HSA-8951664;Reactome: R-HSA-174084;Reactome: R-HSA-349425;Reactome: R-HSA-1236978;Reactome: R-HSA-4608870;Reactome: R-HSA-4641257;Reactome: R-HSA-202424;Reactome: R-HSA-75815;Reactome: R-HSA-174154;Reactome: R-HSA-174184;Reactome: R-HSA-8939902;Reactome: R-HSA-2467813;Reactome: R-HSA-5607761;Reactome: R-HSA-5658442;Reactome: R-HSA-983168;Reactome: R-HSA-5689603;Reactome: R-HSA-68827;Reactome: R-HSA-5607764;Reactome: R-HSA-187577;Reactome: R-HSA-180534;Reactome: R-HSA-1234176;Reactome: R-HSA-8948751;Reactome: R-HSA-69481;Reactome: R-HSA-8852276;Reactome: R-HSA-5610783;Reactome: R-HSA-9020702;Reactome: R-HSA-8854050;Reactome: R-HSA-174113;Reactome: R-HSA-5687128;Reactome: R-HSA-5358346;Reactome: R-HSA-69017;Reactome: R-HSA-69601;Reactome: R-HSA-5362768;Reactome: R-HSA-5676590;Reactome: R-HSA-9604323;Reactome: R-HSA-68949;Reactome: R-HSA-1169091;Reactome: R-HSA-382556;Reactome: R-HSA-2871837;Reactome: R-HSA-174178;Reactome: R-HSA-195253;Reactome: R-HSA-1236974;Reactome: R-HSA-450408;Reactome: R-HSA-5610780;Reactome: R-HSA-5632684;Reactome: R-HSA-4641258;Reactome: R-HSA-211733;Reactome: R-HSA-5668541;Reactome: R-HSA-350562;Reactome: R-HSA-9010553;Reactome: R-HSA-8941858	"Defective CFTR causes cystic fibrosis";"Vif-mediated degradation of APOBEC3G";"GLI3 is processed to GLI3R by the proteasome";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Ub-specific processing proteases";"Neddylation";"Autodegradation of Cdh1 by Cdh1:APC/C";"Autodegradation of the E3 ubiquitin ligase COP1";"Cross-presentation of soluble exogenous antigens (endosomes)";"Asymmetric localization of PCP proteins";"Degradation of AXIN";"Downstream TCR signaling";"Ubiquitin-dependent degradation of Cyclin D";"APC/C:Cdc20 mediated degradation of Securin";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Regulation of RUNX2 expression and activity";"Separation of Sister Chromatids";"Dectin-1 mediated noncanonical NF-kB signaling";"Regulation of RAS by GAPs";"Antigen processing: Ubiquitination & Proteasome degradation";"UCH proteinases";"CDT1 association with the CDC6:ORC:origin complex";"CLEC7A (Dectin-1) signaling";"SCF(Skp2)-mediated degradation of p27/p21";"Vpu mediated degradation of CD4";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of PTEN stability and activity";"G2/M Checkpoints";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Degradation of GLI2 by the proteasome";"Interleukin-1 signaling";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"SCF-beta-TrCP mediated degradation of Emi1";"MAPK6/MAPK4 signaling";"Hedgehog ligand biogenesis";"CDK-mediated phosphorylation and removal of Cdc6";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"NIK-->noncanonical NF-kB signaling";"Negative regulation of NOTCH4 signaling";"Orc1 removal from chromatin";"Activation of NF-kappaB in B cells";"ABC-family proteins mediated transport";"FCERI mediated NF-kB activation";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Degradation of beta-catenin by the destruction complex";"ER-Phagosome pathway";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Degradation of GLI1 by the proteasome";"Hedgehog 'on' state";"Degradation of DVL";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"TNFR2 non-canonical NF-kB pathway";"Regulation of ornithine decarboxylase (ODC)";"Regulation of expression of SLITs and ROBOs";"Regulation of RUNX3 expression and activity"
XP_046428266.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046413830.1	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046426400.1	1	KEGG: 00970+6.1.1.16	"Aminoacyl-tRNA biosynthesis"
XP_046434493.1	2	Reactome: R-HSA-6807878;Reactome: R-HSA-6811434	"COPI-mediated anterograde transport";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_046434877.1	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
XP_046420197.1	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
XP_046432406.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_046429487.1	5	MetaCyc: PWY-6891;KEGG: 00900+2.2.1.7;MetaCyc: PWY-7560;MetaCyc: PWY-6892;KEGG: 00730+2.2.1.7	"Thiazole biosynthesis II (aerobic bacteria)";"Terpenoid backbone biosynthesis";"Methylerythritol phosphate pathway II";"Thiazole biosynthesis I (facultative anaerobic bacteria)";"Thiamine metabolism"
XP_046418974.1	27	Reactome: R-HSA-3371453;Reactome: R-HSA-180910;Reactome: R-HSA-3232142;Reactome: R-HSA-170822;Reactome: R-HSA-165054;Reactome: R-HSA-6784531;Reactome: R-HSA-4085377;Reactome: R-HSA-4551638;Reactome: R-HSA-9610379;Reactome: R-HSA-4570464;Reactome: R-HSA-159231;Reactome: R-HSA-1169408;Reactome: R-HSA-3108214;Reactome: R-HSA-168325;Reactome: R-HSA-9609690;Reactome: R-HSA-159236;Reactome: R-HSA-168271;Reactome: R-HSA-159227;Reactome: R-HSA-168333;Reactome: R-HSA-3301854;Reactome: R-HSA-5619107;Reactome: R-HSA-168276;Reactome: R-HSA-4615885;Reactome: R-HSA-191859;Reactome: R-HSA-5578749;Reactome: R-HSA-159230;Reactome: R-HSA-180746	"Regulation of HSF1-mediated heat shock response";"Vpr-mediated nuclear import of PICs";"SUMOylation of ubiquitinylation proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Rev-mediated nuclear export of HIV RNA";"tRNA processing in the nucleus";"SUMOylation of SUMOylation proteins";"SUMOylation of chromatin organization proteins";"HCMV Late Events";"SUMOylation of RNA binding proteins";"Transport of Mature mRNA Derived from an Intronless Transcript";"ISG15 antiviral mechanism";"SUMOylation of DNA damage response and repair proteins";"Viral Messenger RNA Synthesis";"HCMV Early Events";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Transport of Ribonucleoproteins into the Host Nucleus";"Transport of the SLBP independent Mature mRNA";"NEP/NS2 Interacts with the Cellular Export Machinery";"Nuclear Pore Complex (NPC) Disassembly";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"NS1 Mediated Effects on Host Pathways";"SUMOylation of DNA replication proteins";"snRNP Assembly";"Transcriptional regulation by small RNAs";"Transport of the SLBP Dependant Mature mRNA";"Nuclear import of Rev protein"
XP_046412388.1	5	Reactome: R-HSA-6811436;Reactome: R-HSA-6807878;Reactome: R-HSA-3371497;Reactome: R-HSA-2132295;Reactome: R-HSA-983231	"COPI-independent Golgi-to-ER retrograde traffic";"COPI-mediated anterograde transport";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"MHC class II antigen presentation";"Factors involved in megakaryocyte development and platelet production"
XP_046413901.1	1	Reactome: R-HSA-1632852	"Macroautophagy"
XP_046425086.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046426571.1	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
XP_046423197.1	1	Reactome: R-HSA-8949664	"Processing of SMDT1"
XP_046422147.1	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
XP_046435592.1	2	Reactome: R-HSA-8876198;Reactome: R-HSA-8873719	"RAB GEFs exchange GTP for GDP on RABs";"RAB geranylgeranylation"
XP_046411692.1	13	MetaCyc: PWY-6902;KEGG: 00513+3.2.1.52;MetaCyc: PWY-7822;Reactome: R-HSA-2160916;KEGG: 00531+3.2.1.52;KEGG: 00520+3.2.1.52;Reactome: R-HSA-2024101;Reactome: R-HSA-1660662;MetaCyc: PWY-7883;Reactome: R-HSA-2022857;KEGG: 00604+3.2.1.52;KEGG: 00511+3.2.1.52;KEGG: 00603+3.2.1.52	"Chitin degradation II (Vibrio)";"Various types of N-glycan biosynthesis";"Chitin degradation III (Serratia)";"Hyaluronan uptake and degradation";"Glycosaminoglycan degradation";"Amino sugar and nucleotide sugar metabolism";"CS/DS degradation";"Glycosphingolipid metabolism";"Anhydromuropeptides recycling II";"Keratan sulfate degradation";"Glycosphingolipid biosynthesis - ganglio series";"Other glycan degradation";"Glycosphingolipid biosynthesis - globo and isoglobo series"
XP_046434147.1	1	Reactome: R-HSA-6809371	"Formation of the cornified envelope"
XP_046418869.1	1	Reactome: R-HSA-6811438	"Intra-Golgi traffic"
XP_046418095.1	1	Reactome: R-HSA-3214858	"RMTs methylate histone arginines"
XP_046412962.1	16	Reactome: R-HSA-1799339;Reactome: R-HSA-72695;Reactome: R-HSA-192823;Reactome: R-HSA-72689;Reactome: R-HSA-72764;Reactome: R-HSA-72649;Reactome: R-HSA-156902;Reactome: R-HSA-975957;Reactome: R-HSA-2408557;Reactome: R-HSA-72706;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-9633012;Reactome: R-HSA-72702;Reactome: R-HSA-975956;Reactome: R-HSA-6791226	"SRP-dependent cotranslational protein targeting to membrane";"Formation of the ternary complex, and subsequently, the 43S complex";"Viral mRNA Translation";"Formation of a pool of free 40S subunits";"Eukaryotic Translation Termination";"Translation initiation complex formation";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Selenocysteine synthesis";"GTP hydrolysis and joining of the 60S ribosomal subunit";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Ribosomal scanning and start codon recognition";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046430620.1	3	Reactome: R-HSA-6798695;Reactome: R-HSA-6807004;Reactome: R-HSA-202427	"Neutrophil degranulation";"Negative regulation of MET activity";"Phosphorylation of CD3 and TCR zeta chains"
XP_046410951.1	2	Reactome: R-HSA-532668;KEGG: 00511+3.2.1.96	"N-glycan trimming in the ER and Calnexin/Calreticulin cycle";"Other glycan degradation"
XP_046433812.1	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
XP_046420930.1	11	Reactome: R-HSA-380972;KEGG: 04714+2.7.11.1;Reactome: R-HSA-9614657;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05163+2.7.11.1;Reactome: R-HSA-163680;Reactome: R-HSA-6804756;KEGG: 04926+2.7.11.1	"Energy dependent regulation of mTOR by LKB1-AMPK";"Thermogenesis";"FOXO-mediated transcription of cell death genes";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Human cytomegalovirus infection";"AMPK inhibits chREBP transcriptional activation activity";"Regulation of TP53 Activity through Phosphorylation";"Relaxin signaling pathway"
XP_046419799.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046432456.1	5	Reactome: R-HSA-182971;Reactome: R-HSA-8856825;Reactome: R-HSA-8875360;Reactome: R-HSA-8856828;Reactome: R-HSA-6807004	"EGFR downregulation";"Cargo recognition for clathrin-mediated endocytosis";"InlB-mediated entry of Listeria monocytogenes into host cell";"Clathrin-mediated endocytosis";"Negative regulation of MET activity"
XP_046425742.1	11	Reactome: R-HSA-2132295;Reactome: R-HSA-380284;Reactome: R-HSA-6811436;Reactome: R-HSA-380259;Reactome: R-HSA-380320;Reactome: R-HSA-2565942;Reactome: R-HSA-5620912;Reactome: R-HSA-8854518;Reactome: R-HSA-6807878;Reactome: R-HSA-3371497;Reactome: R-HSA-380270	"MHC class II antigen presentation";"Loss of proteins required for interphase microtubule organization from the centrosome";"COPI-independent Golgi-to-ER retrograde traffic";"Loss of Nlp from mitotic centrosomes";"Recruitment of NuMA to mitotic centrosomes";"Regulation of PLK1 Activity at G2/M Transition";"Anchoring of the basal body to the plasma membrane";"AURKA Activation by TPX2";"COPI-mediated anterograde transport";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Recruitment of mitotic centrosome proteins and complexes"
XP_046424928.1	1	Reactome: R-HSA-432720	"Lysosome Vesicle Biogenesis"
XP_046416891.1	1	Reactome: R-HSA-4551638	"SUMOylation of chromatin organization proteins"
XP_046412158.1	1	Reactome: R-HSA-6814848	"Glycerophospholipid catabolism"
XP_046422874.1	1	Reactome: R-HSA-6794361	"Neurexins and neuroligins"
XP_046416686.1	6	Reactome: R-HSA-8951430;Reactome: R-HSA-201722;Reactome: R-HSA-4641265;Reactome: R-HSA-3769402;Reactome: R-HSA-4086398;Reactome: R-HSA-4411364	"RUNX3 regulates WNT signaling";"Formation of the beta-catenin:TCF transactivating complex";"Repression of WNT target genes";"Deactivation of the beta-catenin transactivating complex";"Ca2+ pathway";"Binding of TCF/LEF:CTNNB1 to target gene promoters"
XP_046434507.1	4	Reactome: R-HSA-112043;Reactome: R-HSA-418594;Reactome: R-HSA-202040;Reactome: R-HSA-6814122	"PLC beta mediated events";"G alpha (i) signalling events";"G-protein activation";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"
XP_046419696.1	1	Reactome: R-HSA-77289	"Mitochondrial Fatty Acid Beta-Oxidation"
XP_046418784.1	2	Reactome: R-HSA-983168;Reactome: R-HSA-6798695	"Antigen processing: Ubiquitination & Proteasome degradation";"Neutrophil degranulation"
XP_046425972.1	1	Reactome: R-HSA-3214842	"HDMs demethylate histones"
XP_046420622.1	1	Reactome: R-HSA-2132295	"MHC class II antigen presentation"
XP_046425757.1	1	Reactome: R-HSA-532668	"N-glycan trimming in the ER and Calnexin/Calreticulin cycle"
XP_046436423.1	7	KEGG: 00983+1.1.1.205;Reactome: R-HSA-73817;KEGG: 00230+1.1.1.205;MetaCyc: PWY-6596;MetaCyc: PWY-5695;MetaCyc: PWY-7221;Reactome: R-HSA-6798695	"Drug metabolism - other enzymes";"Purine ribonucleoside monophosphate biosynthesis";"Purine metabolism";"Adenosine nucleotides degradation I";"Inosine 5'-phosphate degradation";"Guanosine ribonucleotides de novo biosynthesis";"Neutrophil degranulation"
XP_046412985.1	1	Reactome: R-HSA-112126	"ALKBH3 mediated reversal of alkylation damage"
XP_046431734.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_046434381.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046436321.1	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
XP_046430084.1	1	Reactome: R-HSA-5693607	"Processing of DNA double-strand break ends"
XP_046425167.1	1	Reactome: R-HSA-69231	"Cyclin D associated events in G1"
XP_046424482.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046421494.1	1	Reactome: R-HSA-2299718	"Condensation of Prophase Chromosomes"
XP_046409813.1	4	KEGG: 00514+2.4.1.255;Reactome: R-HSA-3214847;MetaCyc: PWY-7437;Reactome: R-HSA-5689603	"Other types of O-glycan biosynthesis";"HATs acetylate histones";"Protein O-[N-acetyl]-glucosylation";"UCH proteinases"
XP_046429049.1	5	Reactome: R-HSA-6798695;Reactome: R-HSA-5693571;Reactome: R-HSA-1834949;Reactome: R-HSA-3270619;Reactome: R-HSA-164843	"Neutrophil degranulation";"Nonhomologous End-Joining (NHEJ)";"Cytosolic sensors of pathogen-associated DNA";"IRF3-mediated induction of type I IFN";"2-LTR circle formation"
XP_046424543.1	1	KEGG: 00240+3.1.3.89	"Pyrimidine metabolism"
XP_046419662.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046411884.1	8	KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;Reactome: R-HSA-6791226	"Thermogenesis";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Human cytomegalovirus infection";"Relaxin signaling pathway";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046428419.1	7	KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1	"Thermogenesis";"Human cytomegalovirus infection";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Relaxin signaling pathway";"mTOR signaling pathway";"PI3K-Akt signaling pathway"
XP_046411372.1	9	KEGG: 00511+3.2.1.52;KEGG: 00603+3.2.1.52;KEGG: 00604+3.2.1.52;MetaCyc: PWY-7883;KEGG: 00520+3.2.1.52;KEGG: 00531+3.2.1.52;MetaCyc: PWY-6902;MetaCyc: PWY-7822;KEGG: 00513+3.2.1.52	"Other glycan degradation";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Glycosphingolipid biosynthesis - ganglio series";"Anhydromuropeptides recycling II";"Amino sugar and nucleotide sugar metabolism";"Glycosaminoglycan degradation";"Chitin degradation II (Vibrio)";"Chitin degradation III (Serratia)";"Various types of N-glycan biosynthesis"
XP_046423846.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046418972.1	2	KEGG: 04660+2.7.10.2;Reactome: R-HSA-1433557	"T cell receptor signaling pathway";"Signaling by SCF-KIT"
XP_046411747.1	1	KEGG: 00480+3.4.11.2	"Glutathione metabolism"
XP_046428431.1	7	KEGG: 04926+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1	"Relaxin signaling pathway";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Human cytomegalovirus infection";"Thermogenesis";"PI3K-Akt signaling pathway";"mTOR signaling pathway"
XP_046411562.1	7	Reactome: R-HSA-76061;Reactome: R-HSA-76066;Reactome: R-HSA-73780;Reactome: R-HSA-73980;Reactome: R-HSA-749476;Reactome: R-HSA-1834949;Reactome: R-HSA-76071	"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Chain Elongation";"RNA Polymerase III Transcription Termination";"RNA Polymerase III Abortive And Retractive Initiation";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Transcription Initiation From Type 3 Promoter"
XP_046429443.1	1	Reactome: R-HSA-611105	"Respiratory electron transport"
XP_046434920.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046424019.1	8	KEGG: 04714+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;Reactome: R-HSA-428540;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1	"Thermogenesis";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Activation of RAC1";"Human cytomegalovirus infection";"Relaxin signaling pathway";"mTOR signaling pathway";"PI3K-Akt signaling pathway"
XP_046422999.1	1	Reactome: R-HSA-216083	"Integrin cell surface interactions"
XP_046427634.1	1	Reactome: R-HSA-6807878	"COPI-mediated anterograde transport"
XP_046428545.1	2	Reactome: R-HSA-6804756;Reactome: R-HSA-8854518	"Regulation of TP53 Activity through Phosphorylation";"AURKA Activation by TPX2"
XP_046431988.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_046423220.1	1	Reactome: R-HSA-418886	"Netrin mediated repulsion signals"
XP_046435372.1	2	Reactome: R-HSA-8856828;Reactome: R-HSA-8856825	"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis"
XP_046416079.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046429314.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046429294.1	1	Reactome: R-HSA-400253	"Circadian Clock"
XP_046412172.1	4	Reactome: R-HSA-73614;KEGG: 00983+2.7.1.48;MetaCyc: PWY-7193;KEGG: 00240+2.7.1.48	"Pyrimidine salvage";"Drug metabolism - other enzymes";"Pyrimidine ribonucleosides salvage I";"Pyrimidine metabolism"
XP_046431873.1	14	Reactome: R-HSA-5687128;Reactome: R-HSA-203927;Reactome: R-HSA-9022692;Reactome: R-HSA-9029569;Reactome: R-HSA-426496;Reactome: R-HSA-8934593;Reactome: R-HSA-9018519;Reactome: R-HSA-426486;Reactome: R-HSA-8948700;Reactome: R-HSA-5628897;Reactome: R-HSA-1912408;Reactome: R-HSA-8943723;Reactome: R-HSA-8986944;Reactome: R-HSA-4086398	"MAPK6/MAPK4 signaling";"MicroRNA (miRNA) biogenesis";"Regulation of MECP2 expression and activity";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Post-transcriptional silencing by small RNAs";"Regulation of RUNX1 Expression and Activity";"Estrogen-dependent gene expression";"Small interfering RNA (siRNA) biogenesis";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"TP53 Regulates Metabolic Genes";"Pre-NOTCH Transcription and Translation";"Regulation of PTEN mRNA translation";"Transcriptional Regulation by MECP2";"Ca2+ pathway"
XP_046424465.1	1	Reactome: R-HSA-1483148	"Synthesis of PG"
XP_046415436.1	1	Reactome: R-HSA-373080	"Class B/2 (Secretin family receptors)"
XP_046409403.1	3	Reactome: R-HSA-196807;Reactome: R-HSA-73621;Reactome: R-HSA-74259	"Nicotinate metabolism";"Pyrimidine catabolism";"Purine catabolism"
XP_046435200.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_046410848.1	3	Reactome: R-HSA-749476;Reactome: R-HSA-76061;Reactome: R-HSA-76066	"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Transcription Initiation From Type 2 Promoter"
XP_046417885.1	5	Reactome: R-HSA-190873;Reactome: R-HSA-8856825;Reactome: R-HSA-196025;Reactome: R-HSA-3928665;Reactome: R-HSA-8856828	"Gap junction degradation";"Cargo recognition for clathrin-mediated endocytosis";"Formation of annular gap junctions";"EPH-ephrin mediated repulsion of cells";"Clathrin-mediated endocytosis"
XP_046418960.1	1	Reactome: R-HSA-200425	"Carnitine metabolism"
XP_046415590.1	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
XP_046423966.1	6	Reactome: R-HSA-72695;Reactome: R-HSA-72702;Reactome: R-HSA-72706;Reactome: R-HSA-72649;Reactome: R-HSA-72689;Reactome: R-HSA-156827	"Formation of the ternary complex, and subsequently, the 43S complex";"Ribosomal scanning and start codon recognition";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Translation initiation complex formation";"Formation of a pool of free 40S subunits";"L13a-mediated translational silencing of Ceruloplasmin expression"
XP_046415697.1	2	Reactome: R-HSA-5576892;Reactome: R-HSA-445095	"Phase 0 - rapid depolarisation";"Interaction between L1 and Ankyrins"
XP_046413020.1	1	Reactome: R-HSA-83936	"Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"
XP_046419010.1	2	KEGG: 04660+2.7.10.2;Reactome: R-HSA-1433557	"T cell receptor signaling pathway";"Signaling by SCF-KIT"
XP_046414411.1	5	Reactome: R-HSA-73856;Reactome: R-HSA-77595;Reactome: R-HSA-159231;Reactome: R-HSA-72187;Reactome: R-HSA-72163	"RNA Polymerase II Transcription Termination";"Processing of Intronless Pre-mRNAs";"Transport of Mature mRNA Derived from an Intronless Transcript";"mRNA 3'-end processing";"mRNA Splicing - Major Pathway"
XP_046415547.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046430882.1	2	Reactome: R-HSA-917729;Reactome: R-HSA-9610379	"Endosomal Sorting Complex Required For Transport (ESCRT)";"HCMV Late Events"
XP_046424561.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046417111.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046430688.1	3	MetaCyc: PWY-7831;MetaCyc: PWY-7833;Reactome: R-HSA-9033807	"ABH and Lewis epitopes biosynthesis from type 2 precursor disaccharide";"Biosynthesis of Lewis epitopes (H. pylori)";"ABO blood group biosynthesis"
XP_046426173.1	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_046428789.1	1	Reactome: R-HSA-977225	"Amyloid fiber formation"
XP_046431165.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_046430831.1	1	Reactome: R-HSA-977443	"GABA receptor activation"
XP_046418779.1	7	Reactome: R-HSA-5358346;Reactome: R-HSA-5632681;Reactome: R-HSA-5632684;Reactome: R-HSA-5658034;Reactome: R-HSA-373080;Reactome: R-HSA-5635838;Reactome: R-HSA-5362798	"Hedgehog ligand biogenesis";"Ligand-receptor interactions";"Hedgehog 'on' state";"HHAT G278V abrogates palmitoylation of Hh-Np";"Class B/2 (Secretin family receptors)";"Activation of SMO";"Release of Hh-Np from the secreting cell"
XP_046420561.1	6	Reactome: R-HSA-72689;Reactome: R-HSA-156827;Reactome: R-HSA-72706;Reactome: R-HSA-72702;Reactome: R-HSA-72695;Reactome: R-HSA-72649	"Formation of a pool of free 40S subunits";"L13a-mediated translational silencing of Ceruloplasmin expression";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Ribosomal scanning and start codon recognition";"Formation of the ternary complex, and subsequently, the 43S complex";"Translation initiation complex formation"
XP_046416847.1	6	MetaCyc: PWY-5884;MetaCyc: PWY-7782;Reactome: R-HSA-9640463;MetaCyc: PWY-6733;MetaCyc: PWY-7656;KEGG: 00073+1.2.1.84	"Wax esters biosynthesis I";"Plasmalogen biosynthesis";"Wax biosynthesis";"Sporopollenin precursors biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Cutin, suberine and wax biosynthesis"
XP_046420641.1	2	Reactome: R-HSA-379726;KEGG: 00970+6.1.1.5	"Mitochondrial tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis"
XP_046425820.1	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_046415700.1	2	Reactome: R-HSA-390471;Reactome: R-HSA-1660662	"Association of TriC/CCT with target proteins during biosynthesis";"Glycosphingolipid metabolism"
XP_046416913.1	14	KEGG: 00590+3.1.1.4;Reactome: R-HSA-975634;KEGG: 00592+3.1.1.4;MetaCyc: PWY-7783;MetaCyc: PWY-8051;KEGG: 00564+3.1.1.4+3.1.1.5;KEGG: 00565+3.1.1.4;Reactome: R-HSA-1482788;MetaCyc: PWY-6803;KEGG: 00591+3.1.1.4;MetaCyc: PWY-7417;MetaCyc: PWY-7409;MetaCyc: PWY-8053;MetaCyc: PWY-7416	"Arachidonic acid metabolism";"Retinoid metabolism and transport";"alpha-Linolenic acid metabolism";"Plasmalogen degradation";"Anandamide biosynthesis I";"Glycerophospholipid metabolism";"Ether lipid metabolism";"Acyl chain remodelling of PC";"Phosphatidylcholine acyl editing";"Linoleic acid metabolism";"Phospholipid remodeling (phosphatidate, yeast)";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Anandamide biosynthesis II";"Phospholipid remodeling (phosphatidylcholine, yeast)"
XP_046428773.1	7	KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1	"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Human cytomegalovirus infection";"Thermogenesis";"Relaxin signaling pathway";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection"
XP_046414711.1	1	Reactome: R-HSA-432720	"Lysosome Vesicle Biogenesis"
XP_046413932.1	4	Reactome: R-HSA-8951664;Reactome: R-HSA-6781823;Reactome: R-HSA-8856825;Reactome: R-HSA-5696394	"Neddylation";"Formation of TC-NER Pre-Incision Complex";"Cargo recognition for clathrin-mediated endocytosis";"DNA Damage Recognition in GG-NER"
XP_046424188.1	12	Reactome: R-HSA-173599;MetaCyc: PWY-3801;KEGG: 00561+2.7.7.9;KEGG: 00500+2.7.7.9;KEGG: 00040+2.7.7.9;MetaCyc: PWY-6527;MetaCyc: PWY-7343;MetaCyc: PWY-7817;KEGG: 00052+2.7.7.9;KEGG: 00520+2.7.7.9;Reactome: R-HSA-3322077;MetaCyc: PWY-7238	"Formation of the active cofactor, UDP-glucuronate";"Sucrose degradation II (sucrose synthase)";"Glycerolipid metabolism";"Starch and sucrose metabolism";"Pentose and glucuronate interconversions";"Stachyose degradation";"UDP-alpha-D-glucose biosynthesis I";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Galactose metabolism";"Amino sugar and nucleotide sugar metabolism";"Glycogen synthesis";"Sucrose biosynthesis II"
XP_046430466.1	5	Reactome: R-HSA-77595;Reactome: R-HSA-73856;Reactome: R-HSA-72187;Reactome: R-HSA-72163;Reactome: R-HSA-168315	"Processing of Intronless Pre-mRNAs";"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing";"mRNA Splicing - Major Pathway";"Inhibition of Host mRNA Processing and RNA Silencing"
XP_046419990.1	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
XP_046433246.1	1	Reactome: R-HSA-3295583	"TRP channels"
XP_046412051.1	3	Reactome: R-HSA-983189;Reactome: R-HSA-6811434;Reactome: R-HSA-390471	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic";"Association of TriC/CCT with target proteins during biosynthesis"
XP_046419150.1	2	Reactome: R-HSA-8939243;Reactome: R-HSA-3214858	"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RMTs methylate histone arginines"
XP_046420732.1	42	Reactome: R-HSA-2559580;Reactome: R-HSA-427413;Reactome: R-HSA-110331;Reactome: R-HSA-3214858;Reactome: R-HSA-5693607;Reactome: R-HSA-3214842;Reactome: R-HSA-3214815;Reactome: R-HSA-9616222;Reactome: R-HSA-5250924;Reactome: R-HSA-427389;Reactome: R-HSA-606279;Reactome: R-HSA-3214847;Reactome: R-HSA-8939236;Reactome: R-HSA-171306;Reactome: R-HSA-5693565;Reactome: R-HSA-3214841;Reactome: R-HSA-4551638;Reactome: R-HSA-212300;Reactome: R-HSA-110329;Reactome: R-HSA-2299718;Reactome: R-HSA-9610379;Reactome: R-HSA-1912408;Reactome: R-HSA-73772;Reactome: R-HSA-8936459;Reactome: R-HSA-2559586;Reactome: R-HSA-912446;Reactome: R-HSA-110330;Reactome: R-HSA-427359;Reactome: R-HSA-5334118;Reactome: R-HSA-1221632;Reactome: R-HSA-201722;Reactome: R-HSA-5578749;Reactome: R-HSA-977225;Reactome: R-HSA-5617472;Reactome: R-HSA-5625886;Reactome: R-HSA-73728;Reactome: R-HSA-110328;Reactome: R-HSA-2559582;Reactome: R-HSA-9609690;Reactome: R-HSA-5693571;Reactome: R-HSA-69473;Reactome: R-HSA-9018519	"Oxidative Stress Induced Senescence";"NoRC negatively regulates rRNA expression";"Cleavage of the damaged purine";"RMTs methylate histone arginines";"Processing of DNA double-strand break ends";"HDMs demethylate histones";"HDACs deacetylate histones";"Transcriptional regulation of granulopoiesis";"B-WICH complex positively regulates rRNA expression";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"Deposition of new CENPA-containing nucleosomes at the centromere";"HATs acetylate histones";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Packaging Of Telomere Ends";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"PKMTs methylate histone lysines";"SUMOylation of chromatin organization proteins";"PRC2 methylates histones and DNA";"Cleavage of the damaged pyrimidine";"Condensation of Prophase Chromosomes";"HCMV Late Events";"Pre-NOTCH Transcription and Translation";"RNA Polymerase I Promoter Escape";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"DNA Damage/Telomere Stress Induced Senescence";"Meiotic recombination";"Recognition and association of DNA glycosylase with site containing an affected purine";"SIRT1 negatively regulates rRNA expression";"DNA methylation";"Meiotic synapsis";"Formation of the beta-catenin:TCF transactivating complex";"Transcriptional regulation by small RNAs";"Amyloid fiber formation";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3";"RNA Polymerase I Promoter Opening";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"Senescence-Associated Secretory Phenotype (SASP)";"HCMV Early Events";"Nonhomologous End-Joining (NHEJ)";"G2/M DNA damage checkpoint";"Estrogen-dependent gene expression"
XP_046411611.1	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276	"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination"
XP_046409755.1	1	Reactome: R-HSA-6803157	"Antimicrobial peptides"
XP_046434852.1	1	Reactome: R-HSA-418594	"G alpha (i) signalling events"
XP_046436667.1	12	Reactome: R-HSA-141444;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813;Reactome: R-HSA-9646399;Reactome: R-HSA-6811436;Reactome: R-HSA-9609690;Reactome: R-HSA-68877;Reactome: R-HSA-2132295;Reactome: R-HSA-3371497;Reactome: R-HSA-6807878;Reactome: R-HSA-2500257;Reactome: R-HSA-5663220	"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids";"Aggrephagy";"COPI-independent Golgi-to-ER retrograde traffic";"HCMV Early Events";"Mitotic Prometaphase";"MHC class II antigen presentation";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-mediated anterograde transport";"Resolution of Sister Chromatid Cohesion";"RHO GTPases Activate Formins"
XP_046432864.1	2	Reactome: R-HSA-9020702;Reactome: R-HSA-6798695	"Interleukin-1 signaling";"Neutrophil degranulation"
XP_046417518.1	6	MetaCyc: PWY-7782;MetaCyc: PWY-5884;KEGG: 00073+1.2.1.84;MetaCyc: PWY-7656;Reactome: R-HSA-9640463;MetaCyc: PWY-6733	"Plasmalogen biosynthesis";"Wax esters biosynthesis I";"Cutin, suberine and wax biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Wax biosynthesis";"Sporopollenin precursors biosynthesis"
XP_046433826.1	7	KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1	"Thermogenesis";"Human cytomegalovirus infection";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Relaxin signaling pathway";"mTOR signaling pathway";"PI3K-Akt signaling pathway"
XP_046435886.1	3	Reactome: R-HSA-445095;Reactome: R-HSA-6807878;Reactome: R-HSA-8963901	"Interaction between L1 and Ankyrins";"COPI-mediated anterograde transport";"Chylomicron remodeling"
XP_046424964.1	1	MetaCyc: PWY-7942	"5-oxo-L-proline metabolism"
XP_046418019.1	1	Reactome: R-HSA-5223345	"Miscellaneous transport and binding events"
XP_046434246.1	1	Reactome: R-HSA-373080	"Class B/2 (Secretin family receptors)"
XP_046421992.1	2	Reactome: R-HSA-418457;Reactome: R-HSA-1296052	"cGMP effects";"Ca2+ activated K+ channels"
XP_046422466.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_046434590.1	22	Reactome: R-HSA-4641262;Reactome: R-HSA-5339716;Reactome: R-HSA-5675221;Reactome: R-HSA-432142;Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-5467348;Reactome: R-HSA-5467337;Reactome: R-HSA-196299;Reactome: R-HSA-5358749;Reactome: R-HSA-5358747;Reactome: R-HSA-5467340;Reactome: R-HSA-6811558;Reactome: R-HSA-195253;Reactome: R-HSA-2467813;Reactome: R-HSA-5358752;Reactome: R-HSA-9648025;Reactome: R-HSA-141444;Reactome: R-HSA-5358751;Reactome: R-HSA-5673000;Reactome: R-HSA-2500257;Reactome: R-HSA-389513	"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"Misspliced GSK3beta mutants stabilize beta-catenin";"Negative regulation of MAPK pathway";"Platelet sensitization by LDL";"Mitotic Prometaphase";"RHO GTPases Activate Formins";"Truncations of AMER1 destabilize the destruction complex";"APC truncation mutants have impaired AXIN binding";"Beta-catenin phosphorylation cascade";"S37 mutants of beta-catenin aren't phosphorylated";"S33 mutants of beta-catenin aren't phosphorylated";"AXIN missense mutants destabilize the destruction complex";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"Degradation of beta-catenin by the destruction complex";"Separation of Sister Chromatids";"T41 mutants of beta-catenin aren't phosphorylated";"EML4 and NUDC in mitotic spindle formation";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"S45 mutants of beta-catenin aren't phosphorylated";"RAF activation";"Resolution of Sister Chromatid Cohesion";"CTLA4 inhibitory signaling"
XP_046429007.1	2	Reactome: R-HSA-429947;Reactome: R-HSA-6804115	"Deadenylation of mRNA";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"
XP_046432523.1	5	MetaCyc: PWY-6368;MetaCyc: PWY-6580;Reactome: R-HSA-1660499;KEGG: 00562+3.1.3.64;KEGG: 04070+3.1.3.64	"3-phosphoinositide degradation";"Phosphatidylinositol biosynthesis I (bacteria)";"Synthesis of PIPs at the plasma membrane";"Inositol phosphate metabolism";"Phosphatidylinositol signaling system"
XP_046424515.1	1	Reactome: R-HSA-156842	"Eukaryotic Translation Elongation"
XP_046433712.1	2	Reactome: R-HSA-8949664;Reactome: R-HSA-8949215	"Processing of SMDT1";"Mitochondrial calcium ion transport"
XP_046416883.1	3	Reactome: R-HSA-2299718;Reactome: R-HSA-6804760;Reactome: R-HSA-3214841	"Condensation of Prophase Chromosomes";"Regulation of TP53 Activity through Methylation";"PKMTs methylate histone lysines"
XP_046436223.1	3	Reactome: R-HSA-1445148;Reactome: R-HSA-5620916;Reactome: R-HSA-264876	"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"VxPx cargo-targeting to cilium";"Insulin processing"
XP_046421218.1	3	Reactome: R-HSA-1445148;Reactome: R-HSA-5620916;Reactome: R-HSA-264876	"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"VxPx cargo-targeting to cilium";"Insulin processing"
XP_046412174.1	4	KEGG: 00240+2.7.1.48;MetaCyc: PWY-7193;KEGG: 00983+2.7.1.48;Reactome: R-HSA-73614	"Pyrimidine metabolism";"Pyrimidine ribonucleosides salvage I";"Drug metabolism - other enzymes";"Pyrimidine salvage"
XP_046415780.1	2	Reactome: R-HSA-8866907;Reactome: R-HSA-8866904	"Activation of the TFAP2 (AP-2) family of transcription factors";"Negative regulation of activity of TFAP2 (AP-2) family transcription factors"
XP_046428060.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_046412066.1	1	Reactome: R-HSA-977347	"Serine biosynthesis"
XP_046419537.1	27	Reactome: R-HSA-170822;Reactome: R-HSA-3232142;Reactome: R-HSA-180910;Reactome: R-HSA-3371453;Reactome: R-HSA-4551638;Reactome: R-HSA-6784531;Reactome: R-HSA-4085377;Reactome: R-HSA-165054;Reactome: R-HSA-4570464;Reactome: R-HSA-9610379;Reactome: R-HSA-159236;Reactome: R-HSA-9609690;Reactome: R-HSA-168325;Reactome: R-HSA-1169408;Reactome: R-HSA-3108214;Reactome: R-HSA-159231;Reactome: R-HSA-168271;Reactome: R-HSA-168333;Reactome: R-HSA-159227;Reactome: R-HSA-168276;Reactome: R-HSA-5619107;Reactome: R-HSA-3301854;Reactome: R-HSA-159230;Reactome: R-HSA-5578749;Reactome: R-HSA-180746;Reactome: R-HSA-191859;Reactome: R-HSA-4615885	"Regulation of Glucokinase by Glucokinase Regulatory Protein";"SUMOylation of ubiquitinylation proteins";"Vpr-mediated nuclear import of PICs";"Regulation of HSF1-mediated heat shock response";"SUMOylation of chromatin organization proteins";"tRNA processing in the nucleus";"SUMOylation of SUMOylation proteins";"Rev-mediated nuclear export of HIV RNA";"SUMOylation of RNA binding proteins";"HCMV Late Events";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"HCMV Early Events";"Viral Messenger RNA Synthesis";"ISG15 antiviral mechanism";"SUMOylation of DNA damage response and repair proteins";"Transport of Mature mRNA Derived from an Intronless Transcript";"Transport of Ribonucleoproteins into the Host Nucleus";"NEP/NS2 Interacts with the Cellular Export Machinery";"Transport of the SLBP independent Mature mRNA";"NS1 Mediated Effects on Host Pathways";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Nuclear Pore Complex (NPC) Disassembly";"Transport of the SLBP Dependant Mature mRNA";"Transcriptional regulation by small RNAs";"Nuclear import of Rev protein";"snRNP Assembly";"SUMOylation of DNA replication proteins"
XP_046429447.1	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
XP_046434067.1	2	Reactome: R-HSA-8939243;Reactome: R-HSA-3214858	"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RMTs methylate histone arginines"
XP_046409746.1	3	KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16	"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
XP_046424157.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046433081.1	3	Reactome: R-HSA-6798695;Reactome: R-HSA-6807004;Reactome: R-HSA-202427	"Neutrophil degranulation";"Negative regulation of MET activity";"Phosphorylation of CD3 and TCR zeta chains"
XP_046431996.1	1	Reactome: R-HSA-1474228	"Degradation of the extracellular matrix"
XP_046417767.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046425974.1	1	Reactome: R-HSA-3214842	"HDMs demethylate histones"
XP_046411749.1	1	KEGG: 00480+3.4.11.2	"Glutathione metabolism"
XP_046431808.1	2	Reactome: R-HSA-6804115;Reactome: R-HSA-429947	"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Deadenylation of mRNA"
XP_046428673.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_046421008.1	1	Reactome: R-HSA-432047	"Passive transport by Aquaporins"
XP_046413108.1	1	Reactome: R-HSA-1632852	"Macroautophagy"
XP_046416544.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046418266.1	7	Reactome: R-HSA-68877;Reactome: R-HSA-2467813;Reactome: R-HSA-9648025;Reactome: R-HSA-5626467;Reactome: R-HSA-141444;Reactome: R-HSA-5663220;Reactome: R-HSA-2500257	"Mitotic Prometaphase";"Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation";"RHO GTPases activate IQGAPs";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"RHO GTPases Activate Formins";"Resolution of Sister Chromatid Cohesion"
XP_046418318.1	44	Reactome: R-HSA-198753;Reactome: R-HSA-879415;Reactome: R-HSA-2029482;Reactome: R-HSA-5675221;Reactome: R-HSA-456926;Reactome: R-HSA-9634638;Reactome: R-HSA-9635465;Reactome: R-HSA-2559580;KEGG: 04150+2.7.11.24;Reactome: R-HSA-2559585;Reactome: R-HSA-444257;Reactome: R-HSA-6802955;Reactome: R-HSA-375165;Reactome: R-HSA-3371453;Reactome: R-HSA-8940973;Reactome: R-HSA-881907;Reactome: R-HSA-2871796;Reactome: R-HSA-162658;Reactome: R-HSA-5654732;Reactome: R-HSA-202670;Reactome: R-HSA-8943724;Reactome: R-HSA-9627069;Reactome: R-HSA-170968;Reactome: R-HSA-445144;Reactome: R-HSA-9649948;Reactome: R-HSA-6802952;Reactome: R-HSA-2559582;Reactome: R-HSA-6802948;Reactome: R-HSA-5663213;Reactome: R-HSA-5674135;Reactome: R-HSA-5654733;Reactome: R-HSA-112409;Reactome: R-HSA-5668599;Reactome: R-HSA-5654727;Reactome: R-HSA-6811558;Reactome: R-HSA-74749;Reactome: R-HSA-5654726;Reactome: R-HSA-1295596;Reactome: R-HSA-982772;Reactome: R-HSA-5674499;Reactome: R-HSA-8939211;Reactome: R-HSA-450341;Reactome: R-HSA-6802946;Reactome: R-HSA-5673001	"ERK/MAPK targets";"Advanced glycosylation endproduct receptor signaling";"Regulation of actin dynamics for phagocytic cup formation";"Negative regulation of MAPK pathway";"Thrombin signalling through proteinase activated receptors (PARs)";"Estrogen-dependent nuclear events downstream of ESR-membrane signaling";"Suppression of apoptosis";"Oxidative Stress Induced Senescence";"mTOR signaling pathway";"Oncogene Induced Senescence";"RSK activation";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"NCAM signaling for neurite out-growth";"Regulation of HSF1-mediated heat shock response";"RUNX2 regulates osteoblast differentiation";"Gastrin-CREB signalling pathway via PKC and MAPK";"FCERI mediated MAPK activation";"Golgi Cisternae Pericentriolar Stack Reorganization";"Negative regulation of FGFR3 signaling";"ERKs are inactivated";"Regulation of PTEN gene transcription";"Regulation of the apoptosome activity";"Frs2-mediated activation";"Signal transduction by L1";"Signaling downstream of RAS mutants";"Signaling by BRAF and RAF fusions";"Senescence-Associated Secretory Phenotype (SASP)";"Signaling by high-kinase activity BRAF mutants";"RHO GTPases Activate WASPs and WAVEs";"MAP2K and MAPK activation";"Negative regulation of FGFR4 signaling";"RAF-independent MAPK1/3 activation";"RHO GTPases Activate NADPH Oxidases";"Negative regulation of FGFR2 signaling";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"Signal attenuation";"Negative regulation of FGFR1 signaling";"Spry regulation of FGF signaling";"Growth hormone receptor signaling";"Negative feedback regulation of MAPK pathway";"ESR-mediated signaling";"Activation of the AP-1 family of transcription factors";"Signaling by moderate kinase activity BRAF mutants";"RAF/MAP kinase cascade"
XP_046432712.1	2	Reactome: R-HSA-8862803;Reactome: R-HSA-69273	"Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models";"Cyclin A/B1/B2 associated events during G2/M transition"
XP_046422573.1	4	Reactome: R-HSA-5693579;Reactome: R-HSA-5685942;Reactome: R-HSA-5693554;Reactome: R-HSA-5693568	"Homologous DNA Pairing and Strand Exchange";"HDR through Homologous Recombination (HRR)";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Resolution of D-loop Structures through Holliday Junction Intermediates"
XP_046412391.1	1	Reactome: R-HSA-912446	"Meiotic recombination"
XP_046434123.1	13	MetaCyc: PWY-6902;MetaCyc: PWY-7822;KEGG: 00513+3.2.1.52;Reactome: R-HSA-2160916;KEGG: 00531+3.2.1.52;KEGG: 00520+3.2.1.52;Reactome: R-HSA-2024101;Reactome: R-HSA-1660662;MetaCyc: PWY-7883;Reactome: R-HSA-2022857;KEGG: 00604+3.2.1.52;KEGG: 00511+3.2.1.52;KEGG: 00603+3.2.1.52	"Chitin degradation II (Vibrio)";"Chitin degradation III (Serratia)";"Various types of N-glycan biosynthesis";"Hyaluronan uptake and degradation";"Glycosaminoglycan degradation";"Amino sugar and nucleotide sugar metabolism";"CS/DS degradation";"Glycosphingolipid metabolism";"Anhydromuropeptides recycling II";"Keratan sulfate degradation";"Glycosphingolipid biosynthesis - ganglio series";"Other glycan degradation";"Glycosphingolipid biosynthesis - globo and isoglobo series"
XP_046418715.1	3	KEGG: 04660+2.7.10.2;Reactome: R-HSA-391160;Reactome: R-HSA-4420097	"T cell receptor signaling pathway";"Signal regulatory protein family interactions";"VEGFA-VEGFR2 Pathway"
XP_046411187.1	2	Reactome: R-HSA-376176;Reactome: R-HSA-5663220	"Signaling by ROBO receptors";"RHO GTPases Activate Formins"
XP_046417796.1	5	Reactome: R-HSA-8939243;Reactome: R-HSA-201722;Reactome: R-HSA-1266695;Reactome: R-HSA-3214858;Reactome: R-HSA-3247509	"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"Formation of the beta-catenin:TCF transactivating complex";"Interleukin-7 signaling";"RMTs methylate histone arginines";"Chromatin modifying enzymes"
XP_046417584.1	3	Reactome: R-HSA-264876;Reactome: R-HSA-5620916;Reactome: R-HSA-1445148	"Insulin processing";"VxPx cargo-targeting to cilium";"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
XP_046429695.1	1	Reactome: R-HSA-388844	"Receptor-type tyrosine-protein phosphatases"
XP_046413974.1	7	Reactome: R-HSA-380284;Reactome: R-HSA-5620912;Reactome: R-HSA-8854518;Reactome: R-HSA-380259;Reactome: R-HSA-380320;Reactome: R-HSA-380270;Reactome: R-HSA-2565942	"Loss of proteins required for interphase microtubule organization from the centrosome";"Anchoring of the basal body to the plasma membrane";"AURKA Activation by TPX2";"Loss of Nlp from mitotic centrosomes";"Recruitment of NuMA to mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes";"Regulation of PLK1 Activity at G2/M Transition"
XP_046419325.1	6	Reactome: R-HSA-5685938;Reactome: R-HSA-5693607;Reactome: R-HSA-176187;Reactome: R-HSA-5693616;Reactome: R-HSA-6804756;Reactome: R-HSA-69473	"HDR through Single Strand Annealing (SSA)";"Processing of DNA double-strand break ends";"Activation of ATR in response to replication stress";"Presynaptic phase of homologous DNA pairing and strand exchange";"Regulation of TP53 Activity through Phosphorylation";"G2/M DNA damage checkpoint"
XP_046427737.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_046409395.1	3	Reactome: R-HSA-74259;Reactome: R-HSA-196807;Reactome: R-HSA-73621	"Purine catabolism";"Nicotinate metabolism";"Pyrimidine catabolism"
XP_046434975.1	1	Reactome: R-HSA-390651	"Dopamine receptors"
XP_046427554.1	1	Reactome: R-HSA-1660661	"Sphingolipid de novo biosynthesis"
XP_046431775.1	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840	"Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation"
XP_046435736.1	1	Reactome: R-HSA-1221632	"Meiotic synapsis"
XP_046421988.1	2	Reactome: R-HSA-418457;Reactome: R-HSA-1296052	"cGMP effects";"Ca2+ activated K+ channels"
XP_046433770.1	1	Reactome: R-HSA-6811440	"Retrograde transport at the Trans-Golgi-Network"
XP_046426157.1	4	KEGG: 00100+1.3.1.72;MetaCyc: PWY-8026;Reactome: R-HSA-6807047;Reactome: R-HSA-6807062	"Steroid biosynthesis";"Sterol biosynthesis (methylotrophs)";"Cholesterol biosynthesis via desmosterol";"Cholesterol biosynthesis via lathosterol"
XP_046415990.1	1	Reactome: R-HSA-70895	"Branched-chain amino acid catabolism"
XP_046414676.1	1	Reactome: R-HSA-432720	"Lysosome Vesicle Biogenesis"
XP_046415670.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_046427519.1	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_046410974.1	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
XP_046423854.1	1	Reactome: R-HSA-71384	"Ethanol oxidation"
XP_046428094.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_046427454.1	11	MetaCyc: PWY-3881;MetaCyc: PWY-882;Reactome: R-HSA-4043916;KEGG: 00520+5.3.1.8;MetaCyc: PWY-7456;MetaCyc: PWY-5659;MetaCyc: PWY-6992;MetaCyc: PWY-3861;Reactome: R-HSA-446205;MetaCyc: PWY-7586;KEGG: 00051+5.3.1.8	"Mannitol biosynthesis";"L-ascorbate biosynthesis I (L-galactose pathway)";"Defective MPI causes MPI-CDG (CDG-1b)";"Amino sugar and nucleotide sugar metabolism";"Beta-(1,4)-mannan degradation";"GDP-mannose biosynthesis";"1,5-anhydrofructose degradation";"Mannitol degradation II";"Synthesis of GDP-mannose";"Beta-1,4-d-mannosyl-n-acetyl-d-glucosamine degradation";"Fructose and mannose metabolism"
XP_046434037.1	1	Reactome: R-HSA-1296061	"HCN channels"
XP_046422255.1	6	Reactome: R-HSA-76005;Reactome: R-HSA-416993;Reactome: R-HSA-114516;Reactome: R-HSA-5099900;Reactome: R-HSA-418597;KEGG: 04070+2.7.11.13	"Response to elevated platelet cytosolic Ca2+";"Trafficking of GluR2-containing AMPA receptors";"Disinhibition of SNARE formation";"WNT5A-dependent internalization of FZD4";"G alpha (z) signalling events";"Phosphatidylinositol signaling system"
XP_046432030.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_046419406.1	2	KEGG: 00900+2.5.1.58;Reactome: R-HSA-2514859	"Terpenoid backbone biosynthesis";"Inactivation, recovery and regulation of the phototransduction cascade"
XP_046411904.1	2	Reactome: R-HSA-3214847;Reactome: R-HSA-427413	"HATs acetylate histones";"NoRC negatively regulates rRNA expression"
XP_046431927.1	13	Reactome: R-HSA-416993;Reactome: R-HSA-437239;Reactome: R-HSA-3928665;Reactome: R-HSA-8856825;Reactome: R-HSA-5140745;Reactome: R-HSA-5099900;Reactome: R-HSA-8856828;Reactome: R-HSA-2132295;Reactome: R-HSA-177504;Reactome: R-HSA-8866427;Reactome: R-HSA-182218;Reactome: R-HSA-8964038;Reactome: R-HSA-167590	"Trafficking of GluR2-containing AMPA receptors";"Recycling pathway of L1";"EPH-ephrin mediated repulsion of cells";"Cargo recognition for clathrin-mediated endocytosis";"WNT5A-dependent internalization of FZD2, FZD5 and ROR2";"WNT5A-dependent internalization of FZD4";"Clathrin-mediated endocytosis";"MHC class II antigen presentation";"Retrograde neurotrophin signalling";"VLDLR internalisation and degradation";"Nef Mediated CD8 Down-regulation";"LDL clearance";"Nef Mediated CD4 Down-regulation"
XP_046430481.1	4	Reactome: R-HSA-2122947;Reactome: R-HSA-201722;Reactome: R-HSA-4641265;Reactome: R-HSA-3769402	"NOTCH1 Intracellular Domain Regulates Transcription";"Formation of the beta-catenin:TCF transactivating complex";"Repression of WNT target genes";"Deactivation of the beta-catenin transactivating complex"
XP_046411178.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_046427455.1	11	MetaCyc: PWY-3881;KEGG: 00520+5.3.1.8;MetaCyc: PWY-882;Reactome: R-HSA-4043916;MetaCyc: PWY-6992;MetaCyc: PWY-5659;MetaCyc: PWY-7456;Reactome: R-HSA-446205;MetaCyc: PWY-3861;MetaCyc: PWY-7586;KEGG: 00051+5.3.1.8	"Mannitol biosynthesis";"Amino sugar and nucleotide sugar metabolism";"L-ascorbate biosynthesis I (L-galactose pathway)";"Defective MPI causes MPI-CDG (CDG-1b)";"1,5-anhydrofructose degradation";"GDP-mannose biosynthesis";"Beta-(1,4)-mannan degradation";"Synthesis of GDP-mannose";"Mannitol degradation II";"Beta-1,4-d-mannosyl-n-acetyl-d-glucosamine degradation";"Fructose and mannose metabolism"
XP_046421546.1	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286	"Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation"
XP_046428744.1	2	Reactome: R-HSA-8951664;Reactome: R-HSA-983168	"Neddylation";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046430726.1	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286	"Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation"
XP_046432430.1	15	MetaCyc: PWY-7218;MetaCyc: PWY-6886;MetaCyc: PWY-6901;MetaCyc: PWY-2221;MetaCyc: PWY-8004;KEGG: 00010+2.7.1.40;MetaCyc: PWY-5723;MetaCyc: PWY-6142;MetaCyc: PWY-7383;MetaCyc: PWY-1042;KEGG: 00230+2.7.1.40;MetaCyc: PWY-5484;KEGG: 00620+2.7.1.40;MetaCyc: PWY-7003;Reactome: R-HSA-70171	"Photosynthetic 3-hydroxybutanoate biosynthesis (engineered)";"1-butanol autotrophic biosynthesis (engineered)";"Superpathway of glucose and xylose degradation";"Entner-Doudoroff pathway III (semi-phosphorylative)";"Entner-Doudoroff pathway I";"Glycolysis / Gluconeogenesis";"Rubisco shunt";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Anaerobic energy metabolism (invertebrates, cytosol)";"Glycolysis IV (plant cytosol)";"Purine metabolism";"Glycolysis II (from fructose 6-phosphate)";"Pyruvate metabolism";"Glycerol degradation to butanol";"Glycolysis"
XP_046430443.1	5	Reactome: R-HSA-8948751;Reactome: R-HSA-4641257;Reactome: R-HSA-201681;Reactome: R-HSA-5689880;Reactome: R-HSA-5545619	"Regulation of PTEN stability and activity";"Degradation of AXIN";"TCF dependent signaling in response to WNT";"Ub-specific processing proteases";"XAV939 inhibits tankyrase, stabilizing AXIN"
XP_046424139.1	6	Reactome: R-HSA-434316;Reactome: R-HSA-399997;Reactome: R-HSA-418592;Reactome: R-HSA-428930;Reactome: R-HSA-416476;Reactome: R-HSA-456926	"Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion";"Acetylcholine regulates insulin secretion";"ADP signalling through P2Y purinoceptor 1";"Thromboxane signalling through TP receptor";"G alpha (q) signalling events";"Thrombin signalling through proteinase activated receptors (PARs)"
XP_046433029.1	10	Reactome: R-HSA-1912408;Reactome: R-HSA-210744;Reactome: R-HSA-2197563;Reactome: R-HSA-2894862;Reactome: R-HSA-8941856;Reactome: R-HSA-9013695;Reactome: R-HSA-350054;Reactome: R-HSA-2122947;Reactome: R-HSA-2644606;Reactome: R-HSA-9013508	"Pre-NOTCH Transcription and Translation";"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"NOTCH2 intracellular domain regulates transcription";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"RUNX3 regulates NOTCH signaling";"NOTCH4 Intracellular Domain Regulates Transcription";"Notch-HLH transcription pathway";"NOTCH1 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH3 Intracellular Domain Regulates Transcription"
XP_046431971.1	3	Reactome: R-HSA-3928662;Reactome: R-HSA-5663213;Reactome: R-HSA-2029482	"EPHB-mediated forward signaling";"RHO GTPases Activate WASPs and WAVEs";"Regulation of actin dynamics for phagocytic cup formation"
XP_046418904.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046421655.1	2	Reactome: R-HSA-525793;Reactome: R-HSA-373752	"Myogenesis";"Netrin-1 signaling"
XP_046435077.1	7	KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1	"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Relaxin signaling pathway";"Thermogenesis";"Human cytomegalovirus infection"
XP_046420033.1	1	Reactome: R-HSA-203927	"MicroRNA (miRNA) biogenesis"
XP_046425731.1	1	Reactome: R-HSA-1660662	"Glycosphingolipid metabolism"
XP_046422862.1	1	Reactome: R-HSA-426048	"Arachidonate production from DAG"
XP_046428775.1	7	KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1	"Thermogenesis";"Human cytomegalovirus infection";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Relaxin signaling pathway";"mTOR signaling pathway";"PI3K-Akt signaling pathway"
XP_046417402.1	1	Reactome: R-HSA-432047	"Passive transport by Aquaporins"
XP_046422201.1	2	Reactome: R-HSA-8939243;Reactome: R-HSA-3214858	"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RMTs methylate histone arginines"
XP_046429685.1	1	Reactome: R-HSA-388844	"Receptor-type tyrosine-protein phosphatases"
XP_046435887.1	3	Reactome: R-HSA-6807878;Reactome: R-HSA-8963901;Reactome: R-HSA-445095	"COPI-mediated anterograde transport";"Chylomicron remodeling";"Interaction between L1 and Ankyrins"
XP_046431675.1	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
XP_046412198.1	2	Reactome: R-HSA-168276;Reactome: R-HSA-1169408	"NS1 Mediated Effects on Host Pathways";"ISG15 antiviral mechanism"
XP_046411655.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_046418387.1	1	Reactome: R-HSA-1483191	"Synthesis of PC"
XP_046420244.1	20	Reactome: R-HSA-75105;KEGG: 00020+2.3.3.8;KEGG: 00720+2.3.3.8;MetaCyc: PWY-5537;KEGG: 00720+6.2.1.5;Reactome: R-HSA-163765;MetaCyc: PWY-5172;Reactome: R-HSA-6798695;MetaCyc: PWY-6728;MetaCyc: PWY-5538;Reactome: R-HSA-1268020;MetaCyc: PWY-6969;MetaCyc: PWY-7384;Reactome: R-HSA-71403;MetaCyc: PWY-5690;KEGG: 00020+6.2.1.5;MetaCyc: PWY-5392;KEGG: 00660+6.2.1.5;KEGG: 00640+6.2.1.5;MetaCyc: PWY-5913	"Fatty acyl-CoA biosynthesis";"Citrate cycle (TCA cycle)";"Carbon fixation pathways in prokaryotes";"Pyruvate fermentation to acetate V";"Carbon fixation pathways in prokaryotes";"ChREBP activates metabolic gene expression";"Acetyl-coa biosynthesis III (from citrate)";"Neutrophil degranulation";"Methylaspartate cycle";"Pyruvate fermentation to acetate VI";"Mitochondrial protein import";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Anaerobic energy metabolism (invertebrates, mitochondrial)";"Citric acid cycle (TCA cycle)";"TCA cycle II (plants and fungi)";"Citrate cycle (TCA cycle)";"Reductive TCA cycle II";"C5-Branched dibasic acid metabolism";"Propanoate metabolism";"Partial TCA cycle (obligate autotrophs)"
XP_046419602.1	7	MetaCyc: PWY-7886;MetaCyc: PWY-3385;Reactome: R-HSA-1483213;MetaCyc: PWY-7782;MetaCyc: PWY-7818;KEGG: 00564+2.7.1.32+2.7.1.82;Reactome: R-HSA-1483191	"Cell-surface glycoconjugate-linked phosphocholine biosynthesis";"Choline biosynthesis I";"Synthesis of PE";"Plasmalogen biosynthesis";"Type IV lipoteichoic acid biosynthesis (S. pneumoniae)";"Glycerophospholipid metabolism";"Synthesis of PC"
XP_046411748.1	1	KEGG: 00480+3.4.11.2	"Glutathione metabolism"
XP_046419334.1	4	Reactome: R-HSA-8856825;Reactome: R-HSA-5250958;Reactome: R-HSA-8856828;Reactome: R-HSA-6794361	"Cargo recognition for clathrin-mediated endocytosis";"Toxicity of botulinum toxin type B (BoNT/B)";"Clathrin-mediated endocytosis";"Neurexins and neuroligins"
XP_046416045.1	1	Reactome: R-HSA-4419969	"Depolymerisation of the Nuclear Lamina"
XP_046433840.1	1	Reactome: R-HSA-1474228	"Degradation of the extracellular matrix"
XP_046429788.1	1	Reactome: R-HSA-1660499	"Synthesis of PIPs at the plasma membrane"
XP_046431128.1	2	Reactome: R-HSA-390522;Reactome: R-HSA-445355	"Striated Muscle Contraction";"Smooth Muscle Contraction"
XP_046409773.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_046413655.1	2	Reactome: R-HSA-8856825;Reactome: R-HSA-8856828	"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis"
XP_046418852.1	1	Reactome: R-HSA-5620912	"Anchoring of the basal body to the plasma membrane"
XP_046422095.1	1	Reactome: R-HSA-6804754	"Regulation of TP53 Expression"
XP_046413021.1	1	Reactome: R-HSA-83936	"Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"
XP_046413933.1	4	Reactome: R-HSA-8951664;Reactome: R-HSA-6781823;Reactome: R-HSA-5696394;Reactome: R-HSA-8856825	"Neddylation";"Formation of TC-NER Pre-Incision Complex";"DNA Damage Recognition in GG-NER";"Cargo recognition for clathrin-mediated endocytosis"
XP_046413286.1	16	Reactome: R-HSA-8934593;Reactome: R-HSA-4086398;Reactome: R-HSA-9022692;Reactome: R-HSA-8853884;Reactome: R-HSA-5687128;Reactome: R-HSA-9029569;Reactome: R-HSA-426496;Reactome: R-HSA-2559580;Reactome: R-HSA-9018519;Reactome: R-HSA-8936459;Reactome: R-HSA-8943723;Reactome: R-HSA-1912408;Reactome: R-HSA-8986944;Reactome: R-HSA-2559585;Reactome: R-HSA-5628897;Reactome: R-HSA-8948700	"Regulation of RUNX1 Expression and Activity";"Ca2+ pathway";"Regulation of MECP2 expression and activity";"Transcriptional Regulation by VENTX";"MAPK6/MAPK4 signaling";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Post-transcriptional silencing by small RNAs";"Oxidative Stress Induced Senescence";"Estrogen-dependent gene expression";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Regulation of PTEN mRNA translation";"Pre-NOTCH Transcription and Translation";"Transcriptional Regulation by MECP2";"Oncogene Induced Senescence";"TP53 Regulates Metabolic Genes";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation"
XP_046429741.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
XP_046425965.1	29	Reactome: R-HSA-75953;Reactome: R-HSA-427413;Reactome: R-HSA-6781823;Reactome: R-HSA-167246;Reactome: R-HSA-167162;Reactome: R-HSA-6782210;Reactome: R-HSA-113418;Reactome: R-HSA-6781827;Reactome: R-HSA-167158;Reactome: R-HSA-5696400;Reactome: R-HSA-73779;Reactome: R-HSA-6782135;Reactome: R-HSA-73762;Reactome: R-HSA-167160;Reactome: R-HSA-76042;Reactome: R-HSA-167172;Reactome: R-HSA-75955;Reactome: R-HSA-73863;Reactome: R-HSA-112382;Reactome: R-HSA-72086;Reactome: R-HSA-674695;Reactome: R-HSA-73776;Reactome: R-HSA-6796648;Reactome: R-HSA-77075;Reactome: R-HSA-167200;Reactome: R-HSA-73772;Reactome: R-HSA-167161;Reactome: R-HSA-167152;Reactome: R-HSA-5696395	"RNA Polymerase II Transcription Initiation";"NoRC negatively regulates rRNA expression";"Formation of TC-NER Pre-Incision Complex";"Tat-mediated elongation of the HIV-1 transcript";"RNA Polymerase II HIV Promoter Escape";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Formation of the Early Elongation Complex";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Formation of the HIV-1 Early Elongation Complex";"Dual Incision in GG-NER";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Dual incision in TC-NER";"RNA Polymerase I Transcription Initiation";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Transcription of the HIV genome";"RNA Polymerase II Transcription Elongation";"RNA Polymerase I Transcription Termination";"Formation of RNA Pol II elongation complex";"mRNA Capping";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Promoter Escape";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Pol II CTD phosphorylation and interaction with CE";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Polymerase I Promoter Escape";"HIV Transcription Initiation";"Formation of HIV elongation complex in the absence of HIV Tat";"Formation of Incision Complex in GG-NER"
XP_046423258.1	17	MetaCyc: PWY-6679;KEGG: 00720+6.4.1.2;Reactome: R-HSA-2426168;MetaCyc: PWY-5743;MetaCyc: PWY-5789;KEGG: 00061+6.4.1.2;Reactome: R-HSA-3371599;MetaCyc: PWY-4381;Reactome: R-HSA-196780;KEGG: 00640+6.4.1.2;Reactome: R-HSA-200425;MetaCyc: PWY-5966-1;KEGG: 00620+6.4.1.2;Reactome: R-HSA-163765;MetaCyc: PWY-6722;KEGG: 00254+6.4.1.2;MetaCyc: PWY-5744	"Jadomycin biosynthesis";"Carbon fixation pathways in prokaryotes";"Activation of gene expression by SREBF (SREBP)";"3-hydroxypropanoate cycle";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Fatty acid biosynthesis";"Defective HLCS causes multiple carboxylase deficiency";"Fatty acid biosynthesis initiation (bacteria and plants)";"Biotin transport and metabolism";"Propanoate metabolism";"Carnitine metabolism";"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)";"Pyruvate metabolism";"ChREBP activates metabolic gene expression";"Candicidin biosynthesis";"Aflatoxin biosynthesis";"Glyoxylate assimilation"
XP_046416827.1	14	MetaCyc: PWY-7409;MetaCyc: PWY-7416;MetaCyc: PWY-8053;KEGG: 00591+3.1.1.4;MetaCyc: PWY-7417;KEGG: 00564+3.1.1.4+3.1.1.5;MetaCyc: PWY-8051;Reactome: R-HSA-1482788;MetaCyc: PWY-6803;KEGG: 00565+3.1.1.4;Reactome: R-HSA-975634;KEGG: 00590+3.1.1.4;MetaCyc: PWY-7783;KEGG: 00592+3.1.1.4	"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Anandamide biosynthesis II";"Linoleic acid metabolism";"Phospholipid remodeling (phosphatidate, yeast)";"Glycerophospholipid metabolism";"Anandamide biosynthesis I";"Acyl chain remodelling of PC";"Phosphatidylcholine acyl editing";"Ether lipid metabolism";"Retinoid metabolism and transport";"Arachidonic acid metabolism";"Plasmalogen degradation";"alpha-Linolenic acid metabolism"
XP_046426132.1	10	MetaCyc: PWY-6369;MetaCyc: PWY-6372;KEGG: 04070+2.7.1.158;MetaCyc: PWY-4661;Reactome: R-HSA-1855191;Reactome: R-HSA-1855167;MetaCyc: PWY-6361;MetaCyc: PWY-6362;KEGG: 00562+2.7.1.158;MetaCyc: PWY-6554	"Inositol diphosphates biosynthesis";"1D-myo-inositol hexakisphosphate biosynthesis IV (Dictyostelium)";"Phosphatidylinositol signaling system";"1D-myo-inositol hexakisphosphate biosynthesis III (Spirodela polyrrhiza)";"Synthesis of IPs in the nucleus";"Synthesis of pyrophosphates in the cytosol";"1D-myo-inositol hexakisphosphate biosynthesis I (from Ins(1,4,5)P3)";"1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)";"Inositol phosphate metabolism";"1D-myo-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3)"
XP_046432095.1	7	KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1	"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Human cytomegalovirus infection";"Thermogenesis";"Relaxin signaling pathway";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection"
XP_046435063.1	7	Reactome: R-HSA-76061;Reactome: R-HSA-76066;Reactome: R-HSA-73980;Reactome: R-HSA-73780;Reactome: R-HSA-76071;Reactome: R-HSA-1834949;Reactome: R-HSA-749476	"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Transcription Termination";"RNA Polymerase III Chain Elongation";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Abortive And Retractive Initiation"
XP_046420712.1	14	MetaCyc: PWY-7724;Reactome: R-HSA-75876;MetaCyc: PWY-5972;MetaCyc: PWY-6433;MetaCyc: PWY-7035;MetaCyc: PWY-8041;MetaCyc: PWY-7602;MetaCyc: PWY-6598;MetaCyc: PWY-7036;MetaCyc: PWY-5080;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7601;MetaCyc: PWY-7619;MetaCyc: PWY-7725	"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Synthesis of very long-chain fatty acyl-CoAs";"Stearate biosynthesis I (animals)";"Hydroxylated fatty acid biosynthesis (plants)";"(9Z)-tricosene biosynthesis";"Ultra-long-chain fatty acid biosynthesis";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Sciadonate biosynthesis";"Very long chain fatty acid biosynthesis II";"Very long chain fatty acid biosynthesis I";"Fatty acid elongation";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Juniperonate biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)"
XP_046431504.1	3	KEGG: 00230+2.7.1.20;Reactome: R-HSA-74217;MetaCyc: PWY-6619	"Purine metabolism";"Purine salvage";"Adenine and adenosine salvage VI"
XP_046434875.1	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
XP_046414141.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_046432093.1	7	KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1	"Relaxin signaling pathway";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Human cytomegalovirus infection";"Thermogenesis";"PI3K-Akt signaling pathway";"mTOR signaling pathway"
XP_046436130.1	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046420227.1	10	Reactome: R-HSA-400206;Reactome: R-HSA-9615017;Reactome: R-HSA-9022702;Reactome: R-HSA-8936459;Reactome: R-HSA-9022692;Reactome: R-HSA-9022538;Reactome: R-HSA-3899300;Reactome: R-HSA-9022699;Reactome: R-HSA-983231;Reactome: R-HSA-427413	"Regulation of lipid metabolism by PPARalpha";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"MECP2 regulates transcription of neuronal ligands";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Regulation of MECP2 expression and activity";"Loss of MECP2 binding ability to 5mC-DNA";"SUMOylation of transcription cofactors";"MECP2 regulates neuronal receptors and channels";"Factors involved in megakaryocyte development and platelet production";"NoRC negatively regulates rRNA expression"
XP_046436727.1	11	Reactome: R-HSA-8862803;Reactome: R-HSA-9018519;Reactome: R-HSA-2871796;Reactome: R-HSA-2559582;Reactome: R-HSA-6796648;Reactome: R-HSA-1912408;Reactome: R-HSA-8943724;Reactome: R-HSA-5687128;Reactome: R-HSA-450341;Reactome: R-HSA-5617472;Reactome: R-HSA-2559580	"Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models";"Estrogen-dependent gene expression";"FCERI mediated MAPK activation";"Senescence-Associated Secretory Phenotype (SASP)";"TP53 Regulates Transcription of DNA Repair Genes";"Pre-NOTCH Transcription and Translation";"Regulation of PTEN gene transcription";"MAPK6/MAPK4 signaling";"Activation of the AP-1 family of transcription factors";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Oxidative Stress Induced Senescence"
XP_046430410.1	27	Reactome: R-HSA-191859;Reactome: R-HSA-159230;Reactome: R-HSA-5578749;Reactome: R-HSA-180746;Reactome: R-HSA-4615885;Reactome: R-HSA-3301854;Reactome: R-HSA-5619107;Reactome: R-HSA-168276;Reactome: R-HSA-168333;Reactome: R-HSA-159227;Reactome: R-HSA-168271;Reactome: R-HSA-159236;Reactome: R-HSA-3108214;Reactome: R-HSA-1169408;Reactome: R-HSA-159231;Reactome: R-HSA-168325;Reactome: R-HSA-9609690;Reactome: R-HSA-9610379;Reactome: R-HSA-4570464;Reactome: R-HSA-6784531;Reactome: R-HSA-4085377;Reactome: R-HSA-165054;Reactome: R-HSA-4551638;Reactome: R-HSA-3232142;Reactome: R-HSA-170822;Reactome: R-HSA-180910;Reactome: R-HSA-3371453	"snRNP Assembly";"Transport of the SLBP Dependant Mature mRNA";"Transcriptional regulation by small RNAs";"Nuclear import of Rev protein";"SUMOylation of DNA replication proteins";"Nuclear Pore Complex (NPC) Disassembly";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"NS1 Mediated Effects on Host Pathways";"NEP/NS2 Interacts with the Cellular Export Machinery";"Transport of the SLBP independent Mature mRNA";"Transport of Ribonucleoproteins into the Host Nucleus";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"SUMOylation of DNA damage response and repair proteins";"ISG15 antiviral mechanism";"Transport of Mature mRNA Derived from an Intronless Transcript";"Viral Messenger RNA Synthesis";"HCMV Early Events";"HCMV Late Events";"SUMOylation of RNA binding proteins";"tRNA processing in the nucleus";"SUMOylation of SUMOylation proteins";"Rev-mediated nuclear export of HIV RNA";"SUMOylation of chromatin organization proteins";"SUMOylation of ubiquitinylation proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Vpr-mediated nuclear import of PICs";"Regulation of HSF1-mediated heat shock response"
XP_046421578.1	7	KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1	"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Relaxin signaling pathway";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Human cytomegalovirus infection";"Thermogenesis"
XP_046425960.1	2	Reactome: R-HSA-5673001;Reactome: R-HSA-8853659	"RAF/MAP kinase cascade";"RET signaling"
XP_046422333.1	1	Reactome: R-HSA-5663220	"RHO GTPases Activate Formins"
XP_046419782.1	1	Reactome: R-HSA-390522	"Striated Muscle Contraction"
XP_046424068.1	3	Reactome: R-HSA-194313;Reactome: R-HSA-195399;Reactome: R-HSA-114608	"VEGF ligand-receptor interactions";"VEGF binds to VEGFR leading to receptor dimerization";"Platelet degranulation"
XP_046411865.1	1	Reactome: R-HSA-5221030	"TET1,2,3 and TDG demethylate DNA"
XP_046436471.1	2	Reactome: R-HSA-6807878;Reactome: R-HSA-445095	"COPI-mediated anterograde transport";"Interaction between L1 and Ankyrins"
XP_046422480.1	13	Reactome: R-HSA-156902;Reactome: R-HSA-975956;Reactome: R-HSA-72764;Reactome: R-HSA-975957;Reactome: R-HSA-6791226;Reactome: R-HSA-72706;Reactome: R-HSA-2408557;Reactome: R-HSA-1799339;Reactome: R-HSA-9633012;Reactome: R-HSA-72689;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-192823	"Peptide chain elongation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Selenocysteine synthesis";"SRP-dependent cotranslational protein targeting to membrane";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Formation of a pool of free 40S subunits";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Viral mRNA Translation"
XP_046418854.1	1	Reactome: R-HSA-5620912	"Anchoring of the basal body to the plasma membrane"
XP_046421767.1	4	Reactome: R-HSA-1799339;Reactome: R-HSA-422085;Reactome: R-HSA-400511;Reactome: R-HSA-381771	"SRP-dependent cotranslational protein targeting to membrane";"Synthesis, secretion, and deacylation of Ghrelin";"Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)";"Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)"
XP_046416935.1	9	Reactome: R-HSA-5693568;Reactome: R-HSA-5693579;Reactome: R-HSA-5693607;Reactome: R-HSA-5685942;Reactome: R-HSA-69473;Reactome: R-HSA-6804756;Reactome: R-HSA-5685938;Reactome: R-HSA-5693554;Reactome: R-HSA-5693616	"Resolution of D-loop Structures through Holliday Junction Intermediates";"Homologous DNA Pairing and Strand Exchange";"Processing of DNA double-strand break ends";"HDR through Homologous Recombination (HRR)";"G2/M DNA damage checkpoint";"Regulation of TP53 Activity through Phosphorylation";"HDR through Single Strand Annealing (SSA)";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Presynaptic phase of homologous DNA pairing and strand exchange"
XP_046428170.1	2	Reactome: R-HSA-2206307;Reactome: R-HSA-2024096	"MPS IIIA - Sanfilippo syndrome A";"HS-GAG degradation"
XP_046432140.1	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
XP_046436665.1	4	Reactome: R-HSA-379716;KEGG: 00970+6.1.1.18;Reactome: R-HSA-2408522;Reactome: R-HSA-379726	"Cytosolic tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis";"Selenoamino acid metabolism";"Mitochondrial tRNA aminoacylation"
XP_046425388.1	2	Reactome: R-HSA-6807878;Reactome: R-HSA-6811434	"COPI-mediated anterograde transport";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_046434262.1	3	Reactome: R-HSA-416482;Reactome: R-HSA-194840;Reactome: R-HSA-193648	"G alpha (12/13) signalling events";"Rho GTPase cycle";"NRAGE signals death through JNK"
XP_046422202.1	2	Reactome: R-HSA-3214858;Reactome: R-HSA-8939243	"RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"
XP_046420054.1	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046427428.1	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
XP_046409956.1	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
XP_046423319.1	5	KEGG: 00260+1.1.1.95;MetaCyc: PWY-8010;KEGG: 00680+1.1.1.95;KEGG: 00270+1.1.1.95;Reactome: R-HSA-977347	"Glycine, serine and threonine metabolism";"L-cysteine biosynthesis IX (Trichomonas vaginalis)";"Methane metabolism";"Cysteine and methionine metabolism";"Serine biosynthesis"
XP_046420452.1	2	Reactome: R-HSA-6798695;Reactome: R-HSA-2022377	"Neutrophil degranulation";"Metabolism of Angiotensinogen to Angiotensins"
XP_046436702.1	3	Reactome: R-HSA-1650814;KEGG: 00330+1.14.11.2;MetaCyc: PWY-7894	"Collagen biosynthesis and modifying enzymes";"Arginine and proline metabolism";"Procollagen hydroxylation and glycosylation"
XP_046431932.1	5	Reactome: R-HSA-189085;KEGG: 00520+3.2.1.14;MetaCyc: PWY-6902;MetaCyc: PWY-6855;MetaCyc: PWY-7822	"Digestion of dietary carbohydrate";"Amino sugar and nucleotide sugar metabolism";"Chitin degradation II (Vibrio)";"Chitin degradation I (archaea)";"Chitin degradation III (Serratia)"
XP_046436216.1	2	Reactome: R-HSA-3238698;Reactome: R-HSA-373080	"WNT ligand biogenesis and trafficking";"Class B/2 (Secretin family receptors)"
XP_046423620.1	5	MetaCyc: PWY-5653;MetaCyc: PWY-5381;MetaCyc: PWY-7761;Reactome: R-HSA-196807;KEGG: 00760+2.7.7.18	"NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde";"Pyridine nucleotide cycling (plants)";"NAD salvage pathway II (PNC IV cycle)";"Nicotinate metabolism";"Nicotinate and nicotinamide metabolism"
XP_046425968.1	6	Reactome: R-HSA-380994;Reactome: R-HSA-429958;Reactome: R-HSA-450513;Reactome: R-HSA-450604;Reactome: R-HSA-450385;Reactome: R-HSA-6791226	"ATF4 activates genes in response to endoplasmic reticulum stress";"mRNA decay by 3' to 5' exoribonuclease";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"KSRP (KHSRP) binds and destabilizes mRNA";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046426236.1	1	Reactome: R-HSA-1474228	"Degradation of the extracellular matrix"
XP_046421534.1	1	Reactome: R-HSA-204005	"COPII-mediated vesicle transport"
XP_046421957.1	2	Reactome: R-HSA-418457;Reactome: R-HSA-1296052	"cGMP effects";"Ca2+ activated K+ channels"
XP_046414741.1	1	Reactome: R-HSA-425986	"Sodium/Proton exchangers"
XP_046425747.1	13	Reactome: R-HSA-1799339;Reactome: R-HSA-2408557;Reactome: R-HSA-72706;Reactome: R-HSA-192823;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-72689;Reactome: R-HSA-72764;Reactome: R-HSA-975956;Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-975957	"SRP-dependent cotranslational protein targeting to membrane";"Selenocysteine synthesis";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Formation of a pool of free 40S subunits";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
XP_046428467.1	1	Reactome: R-HSA-5610787	"Hedgehog 'off' state"
XP_046421856.1	1	Reactome: R-HSA-8873719	"RAB geranylgeranylation"
XP_046414461.1	2	Reactome: R-HSA-8949613;Reactome: R-HSA-163210	"Cristae formation";"Formation of ATP by chemiosmotic coupling"
XP_046432701.1	1	Reactome: R-HSA-381753	"Olfactory Signaling Pathway"
XP_046435393.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_046411212.1	9	Reactome: R-HSA-6798695;Reactome: R-HSA-166208;Reactome: R-HSA-1632852;Reactome: R-HSA-380972;Reactome: R-HSA-165159;Reactome: R-HSA-5674135;Reactome: R-HSA-8943724;Reactome: R-HSA-9639288;Reactome: R-HSA-5628897	"Neutrophil degranulation";"mTORC1-mediated signalling";"Macroautophagy";"Energy dependent regulation of mTOR by LKB1-AMPK";"mTOR signalling";"MAP2K and MAPK activation";"Regulation of PTEN gene transcription";"Amino acids regulate mTORC1";"TP53 Regulates Metabolic Genes"
XP_046427322.1	2	Reactome: R-HSA-8856828;Reactome: R-HSA-8856825	"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis"
XP_046417761.1	1	Reactome: R-HSA-2022377	"Metabolism of Angiotensinogen to Angiotensins"
XP_046413402.1	16	KEGG: 00680+4.2.1.11;MetaCyc: PWY-5484;MetaCyc: PWY-7003;MetaCyc: PWY-1042;MetaCyc: PWY-2221;KEGG: 00010+4.2.1.11;MetaCyc: PWY-8004;MetaCyc: PWY-7218;MetaCyc: PWY-6901;MetaCyc: PWY-1622;Reactome: R-HSA-70263;Reactome: R-HSA-70171;MetaCyc: PWY-7124;MetaCyc: PWY-5723;MetaCyc: PWY-6142;MetaCyc: PWY-6886	"Methane metabolism";"Glycolysis II (from fructose 6-phosphate)";"Glycerol degradation to butanol";"Glycolysis IV (plant cytosol)";"Entner-Doudoroff pathway III (semi-phosphorylative)";"Glycolysis / Gluconeogenesis";"Entner-Doudoroff pathway I";"Photosynthetic 3-hydroxybutanoate biosynthesis (engineered)";"Superpathway of glucose and xylose degradation";"Formaldehyde assimilation I (serine pathway)";"Gluconeogenesis";"Glycolysis";"Ethylene biosynthesis V (engineered)";"Rubisco shunt";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"1-butanol autotrophic biosynthesis (engineered)"
XP_046423713.1	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
XP_046424035.1	1	Reactome: R-HSA-2022928	"HS-GAG biosynthesis"
XP_046435385.1	2	Reactome: R-HSA-8856825;Reactome: R-HSA-8856828	"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis"
XP_046431521.1	5	Reactome: R-HSA-111463;Reactome: R-HSA-9627069;Reactome: R-HSA-111457;Reactome: R-HSA-111469;Reactome: R-HSA-111464	"SMAC (DIABLO) binds to IAPs";"Regulation of the apoptosome activity";"Release of apoptotic factors from the mitochondria";"SMAC, XIAP-regulated apoptotic response";"SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes"
XP_046425116.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_046428011.1	1	Reactome: R-HSA-159236	"Transport of Mature mRNA derived from an Intron-Containing Transcript"
XP_046411656.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_046422655.1	4	Reactome: R-HSA-73856;Reactome: R-HSA-72163;Reactome: R-HSA-72187;Reactome: R-HSA-159236	"RNA Polymerase II Transcription Termination";"mRNA Splicing - Major Pathway";"mRNA 3'-end processing";"Transport of Mature mRNA derived from an Intron-Containing Transcript"
XP_046427148.1	26	Reactome: R-HSA-5663220;Reactome: R-HSA-437239;Reactome: R-HSA-389977;Reactome: R-HSA-3371497;Reactome: R-HSA-5617833;Reactome: R-HSA-2132295;Reactome: R-HSA-8955332;Reactome: R-HSA-9609736;Reactome: R-HSA-8852276;Reactome: R-HSA-190840;Reactome: R-HSA-68877;Reactome: R-HSA-190861;Reactome: R-HSA-9646399;Reactome: R-HSA-6811436;Reactome: R-HSA-9619483;Reactome: R-HSA-1445148;Reactome: R-HSA-389960;Reactome: R-HSA-983189;Reactome: R-HSA-2500257;Reactome: R-HSA-5626467;Reactome: R-HSA-6807878;Reactome: R-HSA-6811434;Reactome: R-HSA-9648025;Reactome: R-HSA-380320;Reactome: R-HSA-9609690;Reactome: R-HSA-2467813	"RHO GTPases Activate Formins";"Recycling pathway of L1";"Post-chaperonin tubulin folding pathway";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Cilium Assembly";"MHC class II antigen presentation";"Carboxyterminal post-translational modifications of tubulin";"Assembly and cell surface presentation of NMDA receptors";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Mitotic Prometaphase";"Gap junction assembly";"Aggrephagy";"COPI-independent Golgi-to-ER retrograde traffic";"Activation of AMPK downstream of NMDARs";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Formation of tubulin folding intermediates by CCT/TriC";"Kinesins";"Resolution of Sister Chromatid Cohesion";"RHO GTPases activate IQGAPs";"COPI-mediated anterograde transport";"COPI-dependent Golgi-to-ER retrograde traffic";"EML4 and NUDC in mitotic spindle formation";"Recruitment of NuMA to mitotic centrosomes";"HCMV Early Events";"Separation of Sister Chromatids"
XP_046425304.1	15	Reactome: R-HSA-167246;Reactome: R-HSA-6807505;Reactome: R-HSA-75955;Reactome: R-HSA-112382;Reactome: R-HSA-167238;Reactome: R-HSA-2173796;Reactome: R-HSA-167243;Reactome: R-HSA-674695;Reactome: R-HSA-167287;Reactome: R-HSA-176034;Reactome: R-HSA-167200;Reactome: R-HSA-6796648;Reactome: R-HSA-167290;Reactome: R-HSA-167152;Reactome: R-HSA-9018519	"Tat-mediated elongation of the HIV-1 transcript";"RNA polymerase II transcribes snRNA genes";"RNA Polymerase II Transcription Elongation";"Formation of RNA Pol II elongation complex";"Pausing and recovery of Tat-mediated HIV elongation";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"Tat-mediated HIV elongation arrest and recovery";"RNA Polymerase II Pre-transcription Events";"HIV elongation arrest and recovery";"Interactions of Tat with host cellular proteins";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"TP53 Regulates Transcription of DNA Repair Genes";"Pausing and recovery of HIV elongation";"Formation of HIV elongation complex in the absence of HIV Tat";"Estrogen-dependent gene expression"
XP_046411770.1	1	Reactome: R-HSA-83936	"Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"
XP_046412856.1	2	KEGG: 00230+2.7.4.8;MetaCyc: PWY-7221	"Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis"
XP_046418893.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_046409632.1	10	Reactome: R-HSA-2151201;Reactome: R-HSA-111457;Reactome: R-HSA-3299685;Reactome: R-HSA-111459;Reactome: R-HSA-9627069;Reactome: R-HSA-111463;Reactome: R-HSA-111464;Reactome: R-HSA-611105;Reactome: R-HSA-5628897;Reactome: R-HSA-111458	"Transcriptional activation of mitochondrial biogenesis";"Release of apoptotic factors from the mitochondria";"Detoxification of Reactive Oxygen Species";"Activation of caspases through apoptosome-mediated cleavage";"Regulation of the apoptosome activity";"SMAC (DIABLO) binds to IAPs";"SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes";"Respiratory electron transport";"TP53 Regulates Metabolic Genes";"Formation of apoptosome"
XP_046428697.1	7	KEGG: 00710+3.1.3.11;KEGG: 00680+3.1.3.11;KEGG: 00010+3.1.3.11;Reactome: R-HSA-70263;KEGG: 00051+3.1.3.11;MetaCyc: PWY-5484;KEGG: 00030+3.1.3.11	"Carbon fixation in photosynthetic organisms";"Methane metabolism";"Glycolysis / Gluconeogenesis";"Gluconeogenesis";"Fructose and mannose metabolism";"Glycolysis II (from fructose 6-phosphate)";"Pentose phosphate pathway"
XP_046417544.1	2	Reactome: R-HSA-6798695;Reactome: R-HSA-936837	"Neutrophil degranulation";"Ion transport by P-type ATPases"
XP_046428187.1	3	Reactome: R-HSA-418359;Reactome: R-HSA-425561;Reactome: R-HSA-5578775	"Reduction of cytosolic Ca++ levels";"Sodium/Calcium exchangers";"Ion homeostasis"
XP_046431164.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_046428696.1	7	KEGG: 00010+3.1.3.11;Reactome: R-HSA-70263;KEGG: 00051+3.1.3.11;KEGG: 00710+3.1.3.11;KEGG: 00680+3.1.3.11;MetaCyc: PWY-5484;KEGG: 00030+3.1.3.11	"Glycolysis / Gluconeogenesis";"Gluconeogenesis";"Fructose and mannose metabolism";"Carbon fixation in photosynthetic organisms";"Methane metabolism";"Glycolysis II (from fructose 6-phosphate)";"Pentose phosphate pathway"
XP_046421661.1	2	Reactome: R-HSA-3299685;MetaCyc: PWY-6854	"Detoxification of Reactive Oxygen Species";"Ethylene biosynthesis III (microbes)"
XP_046415068.1	1	Reactome: R-HSA-1660661	"Sphingolipid de novo biosynthesis"
XP_046419405.1	2	Reactome: R-HSA-2514859;KEGG: 00900+2.5.1.58	"Inactivation, recovery and regulation of the phototransduction cascade";"Terpenoid backbone biosynthesis"
XP_046431930.1	5	Reactome: R-HSA-189085;KEGG: 00520+3.2.1.14;MetaCyc: PWY-6855;MetaCyc: PWY-6902;MetaCyc: PWY-7822	"Digestion of dietary carbohydrate";"Amino sugar and nucleotide sugar metabolism";"Chitin degradation I (archaea)";"Chitin degradation II (Vibrio)";"Chitin degradation III (Serratia)"
XP_046430655.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_046420907.1	2	Reactome: R-HSA-8936459;Reactome: R-HSA-3214841	"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"PKMTs methylate histone lysines"
XP_046428145.1	2	Reactome: R-HSA-195253;Reactome: R-HSA-5689896	"Degradation of beta-catenin by the destruction complex";"Ovarian tumor domain proteases"
XP_046409919.1	1	Reactome: R-HSA-373080	"Class B/2 (Secretin family receptors)"
XP_046430479.1	4	Reactome: R-HSA-3769402;Reactome: R-HSA-4641265;Reactome: R-HSA-201722;Reactome: R-HSA-2122947	"Deactivation of the beta-catenin transactivating complex";"Repression of WNT target genes";"Formation of the beta-catenin:TCF transactivating complex";"NOTCH1 Intracellular Domain Regulates Transcription"
XP_046425881.1	3	Reactome: R-HSA-936837;Reactome: R-HSA-5578775;Reactome: R-HSA-418359	"Ion transport by P-type ATPases";"Ion homeostasis";"Reduction of cytosolic Ca++ levels"
XP_046417745.1	1	Reactome: R-HSA-201451	"Signaling by BMP"
XP_046409871.1	2	Reactome: R-HSA-110320;Reactome: R-HSA-983168	"Translesion Synthesis by POLH";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046414787.1	2	Reactome: R-HSA-379726;KEGG: 00970+6.1.1.1	"Mitochondrial tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis"
XP_046418922.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_046435711.1	2	KEGG: 00970+6.3.5.7;Reactome: R-HSA-2142753	"Aminoacyl-tRNA biosynthesis";"Arachidonic acid metabolism"
XP_046424430.1	1	Reactome: R-HSA-2467813	"Separation of Sister Chromatids"
XP_046417813.1	4	Reactome: R-HSA-982772;Reactome: R-HSA-1170546;Reactome: R-HSA-983231;Reactome: R-HSA-2586552	"Growth hormone receptor signaling";"Prolactin receptor signaling";"Factors involved in megakaryocyte development and platelet production";"Signaling by Leptin"
XP_046433662.1	2	Reactome: R-HSA-201722;Reactome: R-HSA-171319	"Formation of the beta-catenin:TCF transactivating complex";"Telomere Extension By Telomerase"
XP_046415940.1	1	Reactome: R-HSA-5620912	"Anchoring of the basal body to the plasma membrane"
XP_046434313.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_046426477.1	1	Reactome: R-HSA-3299685	"Detoxification of Reactive Oxygen Species"
XP_046420147.1	2	Reactome: R-HSA-5628897;Reactome: R-HSA-611105	"TP53 Regulates Metabolic Genes";"Respiratory electron transport"
XP_046419594.1	3	MetaCyc: PWY-6317;KEGG: 00052+5.1.3.3;KEGG: 00010+5.1.3.3	"D-galactose degradation I (Leloir pathway)";"Galactose metabolism";"Glycolysis / Gluconeogenesis"
XP_046434707.1	1	Reactome: R-HSA-5620912	"Anchoring of the basal body to the plasma membrane"
XP_046415570.1	4	Reactome: R-HSA-2395516;Reactome: R-HSA-211976;Reactome: R-HSA-5579026;Reactome: R-HSA-196108	"Electron transport from NADPH to Ferredoxin";"Endogenous sterols";"Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)";"Pregnenolone biosynthesis"
XP_046428774.1	7	KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1	"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Relaxin signaling pathway";"Thermogenesis";"Human cytomegalovirus infection";"mTOR signaling pathway";"PI3K-Akt signaling pathway"
XP_046409399.1	3	Reactome: R-HSA-196807;Reactome: R-HSA-73621;Reactome: R-HSA-74259	"Nicotinate metabolism";"Pyrimidine catabolism";"Purine catabolism"
XP_046419230.1	9	Reactome: R-HSA-6794361;Reactome: R-HSA-8849932;Reactome: R-HSA-9609736;Reactome: R-HSA-442982;Reactome: R-HSA-5673001;Reactome: R-HSA-3928662;Reactome: R-HSA-9620244;Reactome: R-HSA-438066;Reactome: R-HSA-9617324	"Neurexins and neuroligins";"Synaptic adhesion-like molecules";"Assembly and cell surface presentation of NMDA receptors";"Ras activation upon Ca2+ influx through NMDA receptor";"RAF/MAP kinase cascade";"EPHB-mediated forward signaling";"Long-term potentiation";"Unblocking of NMDA receptors, glutamate binding and activation";"Negative regulation of NMDA receptor-mediated neuronal transmission"
XP_046421186.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046427054.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_046423297.1	57	Reactome: R-HSA-8939902;Reactome: R-HSA-174184;Reactome: R-HSA-174154;Reactome: R-HSA-2467813;Reactome: R-HSA-5658442;Reactome: R-HSA-983168;Reactome: R-HSA-5607761;Reactome: R-HSA-6798695;Reactome: R-HSA-5610785;Reactome: R-HSA-180585;Reactome: R-HSA-5678895;Reactome: R-HSA-8939236;Reactome: R-HSA-349425;Reactome: R-HSA-174084;Reactome: R-HSA-5689880;Reactome: R-HSA-8951664;Reactome: R-HSA-75815;Reactome: R-HSA-202424;Reactome: R-HSA-4608870;Reactome: R-HSA-4641257;Reactome: R-HSA-1236978;Reactome: R-HSA-5362768;Reactome: R-HSA-9604323;Reactome: R-HSA-5676590;Reactome: R-HSA-5358346;Reactome: R-HSA-69017;Reactome: R-HSA-69601;Reactome: R-HSA-195253;Reactome: R-HSA-174178;Reactome: R-HSA-2871837;Reactome: R-HSA-1169091;Reactome: R-HSA-382556;Reactome: R-HSA-68949;Reactome: R-HSA-211733;Reactome: R-HSA-4641258;Reactome: R-HSA-5632684;Reactome: R-HSA-450408;Reactome: R-HSA-5610780;Reactome: R-HSA-1236974;Reactome: R-HSA-350562;Reactome: R-HSA-9010553;Reactome: R-HSA-8941858;Reactome: R-HSA-5668541;Reactome: R-HSA-187577;Reactome: R-HSA-180534;Reactome: R-HSA-5607764;Reactome: R-HSA-68827;Reactome: R-HSA-5689603;Reactome: R-HSA-5610783;Reactome: R-HSA-8852276;Reactome: R-HSA-69481;Reactome: R-HSA-1234176;Reactome: R-HSA-8948751;Reactome: R-HSA-9020702;Reactome: R-HSA-8854050;Reactome: R-HSA-5687128;Reactome: R-HSA-174113	"Regulation of RUNX2 expression and activity";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"APC/C:Cdc20 mediated degradation of Securin";"Separation of Sister Chromatids";"Regulation of RAS by GAPs";"Antigen processing: Ubiquitination & Proteasome degradation";"Dectin-1 mediated noncanonical NF-kB signaling";"Neutrophil degranulation";"GLI3 is processed to GLI3R by the proteasome";"Vif-mediated degradation of APOBEC3G";"Defective CFTR causes cystic fibrosis";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Autodegradation of the E3 ubiquitin ligase COP1";"Autodegradation of Cdh1 by Cdh1:APC/C";"Ub-specific processing proteases";"Neddylation";"Ubiquitin-dependent degradation of Cyclin D";"Downstream TCR signaling";"Asymmetric localization of PCP proteins";"Degradation of AXIN";"Cross-presentation of soluble exogenous antigens (endosomes)";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Negative regulation of NOTCH4 signaling";"NIK-->noncanonical NF-kB signaling";"Hedgehog ligand biogenesis";"CDK-mediated phosphorylation and removal of Cdc6";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Degradation of beta-catenin by the destruction complex";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"FCERI mediated NF-kB activation";"Activation of NF-kappaB in B cells";"ABC-family proteins mediated transport";"Orc1 removal from chromatin";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Degradation of DVL";"Hedgehog 'on' state";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Degradation of GLI1 by the proteasome";"ER-Phagosome pathway";"Regulation of ornithine decarboxylase (ODC)";"Regulation of expression of SLITs and ROBOs";"Regulation of RUNX3 expression and activity";"TNFR2 non-canonical NF-kB pathway";"SCF(Skp2)-mediated degradation of p27/p21";"Vpu mediated degradation of CD4";"CLEC7A (Dectin-1) signaling";"CDT1 association with the CDC6:ORC:origin complex";"UCH proteinases";"Degradation of GLI2 by the proteasome";"The role of GTSE1 in G2/M progression after G2 checkpoint";"G2/M Checkpoints";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of PTEN stability and activity";"Interleukin-1 signaling";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"MAPK6/MAPK4 signaling";"SCF-beta-TrCP mediated degradation of Emi1"
XP_046423694.1	4	KEGG: 00510+2.4.1.260;KEGG: 00513+2.4.1.260;Reactome: R-HSA-4720489;Reactome: R-HSA-446193	"N-Glycan biosynthesis";"Various types of N-glycan biosynthesis";"Defective ALG12 causes ALG12-CDG (CDG-1g)";"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein"
XP_046432562.1	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
XP_046409342.1	1	KEGG: 04070+2.7.11.13	"Phosphatidylinositol signaling system"
XP_046429452.1	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
XP_046415317.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046430253.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046414916.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_046431573.1	6	KEGG: 00760+6.3.1.5;MetaCyc: PWY-5653;KEGG: 00760+6.3.5.1;MetaCyc: PWY-5381;MetaCyc: PWY-7761;Reactome: R-HSA-196807	"Nicotinate and nicotinamide metabolism";"NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde";"Nicotinate and nicotinamide metabolism";"Pyridine nucleotide cycling (plants)";"NAD salvage pathway II (PNC IV cycle)";"Nicotinate metabolism"
XP_046425345.1	2	Reactome: R-HSA-162588;Reactome: R-HSA-917729	"Budding and maturation of HIV virion";"Endosomal Sorting Complex Required For Transport (ESCRT)"
XP_046426397.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046415237.1	16	Reactome: R-HSA-975956;Reactome: R-HSA-72702;Reactome: R-HSA-6791226;Reactome: R-HSA-72706;Reactome: R-HSA-2408557;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-72649;Reactome: R-HSA-72764;Reactome: R-HSA-156902;Reactome: R-HSA-975957;Reactome: R-HSA-1799339;Reactome: R-HSA-72695;Reactome: R-HSA-192823;Reactome: R-HSA-72689	"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Ribosomal scanning and start codon recognition";"Major pathway of rRNA processing in the nucleolus and cytosol";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Selenocysteine synthesis";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Translation initiation complex formation";"Eukaryotic Translation Termination";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"Formation of the ternary complex, and subsequently, the 43S complex";"Viral mRNA Translation";"Formation of a pool of free 40S subunits"
XP_046419572.1	7	Reactome: R-HSA-2122948;Reactome: R-HSA-2894862;Reactome: R-HSA-9013507;Reactome: R-HSA-2644606;Reactome: R-HSA-2979096;MetaCyc: PWY-7511;Reactome: R-HSA-2691232	"Activated NOTCH1 Transmits Signal to the Nucleus";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Protein ubiquitination";"Constitutive Signaling by NOTCH1 HD Domain Mutants"
XP_046419154.1	9	Reactome: R-HSA-6802946;Reactome: R-HSA-6798695;Reactome: R-HSA-445355;Reactome: R-HSA-114608;Reactome: R-HSA-6802955;Reactome: R-HSA-5674135;Reactome: R-HSA-6802948;Reactome: R-HSA-6802952;Reactome: R-HSA-9649948	"Signaling by moderate kinase activity BRAF mutants";"Neutrophil degranulation";"Smooth Muscle Contraction";"Platelet degranulation";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"MAP2K and MAPK activation";"Signaling by high-kinase activity BRAF mutants";"Signaling by BRAF and RAF fusions";"Signaling downstream of RAS mutants"
XP_046417703.1	1	Reactome: R-HSA-432047	"Passive transport by Aquaporins"
XP_046415785.1	2	Reactome: R-HSA-379726;KEGG: 00970+6.1.1.20	"Mitochondrial tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis"
XP_046425408.1	2	Reactome: R-HSA-8856825;Reactome: R-HSA-8856828	"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis"
XP_046423076.1	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840	"Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation"
XP_046435449.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046412794.1	2	Reactome: R-HSA-3299685;KEGG: 00480+1.11.1.15	"Detoxification of Reactive Oxygen Species";"Glutathione metabolism"
XP_046419661.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046426249.1	2	MetaCyc: PWY-4261;KEGG: 00561+2.7.1.30	"Glycerol degradation I";"Glycerolipid metabolism"
XP_046431315.1	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
XP_046426772.1	4	MetaCyc: PWY-7494;MetaCyc: PWY-3722;KEGG: 00260+1.2.1.8+1.1.99.1;Reactome: R-HSA-6798163	"Choline degradation IV";"Glycine betaine biosynthesis II (Gram-positive bacteria)";"Glycine, serine and threonine metabolism";"Choline catabolism"
XP_046436416.1	1	Reactome: R-HSA-5689896	"Ovarian tumor domain proteases"
XP_046409966.1	2	Reactome: R-HSA-74217;KEGG: 00230+1.7.1.7	"Purine salvage";"Purine metabolism"
XP_046410804.1	3	Reactome: R-HSA-73856;Reactome: R-HSA-159236;Reactome: R-HSA-72187	"RNA Polymerase II Transcription Termination";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"mRNA 3'-end processing"
XP_046436689.1	12	Reactome: R-HSA-9648025;Reactome: R-HSA-141444;Reactome: R-HSA-68877;Reactome: R-HSA-9609690;Reactome: R-HSA-2467813;Reactome: R-HSA-9646399;Reactome: R-HSA-6811436;Reactome: R-HSA-2132295;Reactome: R-HSA-3371497;Reactome: R-HSA-6807878;Reactome: R-HSA-5663220;Reactome: R-HSA-2500257	"EML4 and NUDC in mitotic spindle formation";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Mitotic Prometaphase";"HCMV Early Events";"Separation of Sister Chromatids";"Aggrephagy";"COPI-independent Golgi-to-ER retrograde traffic";"MHC class II antigen presentation";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-mediated anterograde transport";"RHO GTPases Activate Formins";"Resolution of Sister Chromatid Cohesion"
XP_046427140.1	1	Reactome: R-HSA-420499	"Class C/3 (Metabotropic glutamate/pheromone receptors)"
XP_046416715.1	18	MetaCyc: PWY-7783;Reactome: R-HSA-1482925;MetaCyc: PWY-6803;KEGG: 00564+3.1.1.4;KEGG: 00591+3.1.1.4;MetaCyc: PWY-7416;Reactome: R-HSA-1482839;MetaCyc: PWY-8053;MetaCyc: PWY-7409;KEGG: 00592+3.1.1.4;Reactome: R-HSA-1483166;KEGG: 00590+3.1.1.4;KEGG: 00565+3.1.1.4;Reactome: R-HSA-1482788;MetaCyc: PWY-8051;Reactome: R-HSA-1482922;Reactome: R-HSA-1482801;MetaCyc: PWY-7417	"Plasmalogen degradation";"Acyl chain remodelling of PG";"Phosphatidylcholine acyl editing";"Glycerophospholipid metabolism";"Linoleic acid metabolism";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Acyl chain remodelling of PE";"Anandamide biosynthesis II";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"alpha-Linolenic acid metabolism";"Synthesis of PA";"Arachidonic acid metabolism";"Ether lipid metabolism";"Acyl chain remodelling of PC";"Anandamide biosynthesis I";"Acyl chain remodelling of PI";"Acyl chain remodelling of PS";"Phospholipid remodeling (phosphatidate, yeast)"
XP_046430939.1	1	Reactome: R-HSA-373753	"Nephrin family interactions"
XP_046435737.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_046416848.1	6	KEGG: 00073+1.2.1.84;MetaCyc: PWY-7656;Reactome: R-HSA-9640463;MetaCyc: PWY-6733;MetaCyc: PWY-5884;MetaCyc: PWY-7782	"Cutin, suberine and wax biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Wax biosynthesis";"Sporopollenin precursors biosynthesis";"Wax esters biosynthesis I";"Plasmalogen biosynthesis"
XP_046433621.1	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
XP_046430251.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046415308.1	2	Reactome: R-HSA-446205;KEGG: 00500+2.4.1.15	"Synthesis of GDP-mannose";"Starch and sucrose metabolism"
XP_046419503.1	3	Reactome: R-HSA-3000157;Reactome: R-HSA-3000171;Reactome: R-HSA-8874081	"Laminin interactions";"Non-integrin membrane-ECM interactions";"MET activates PTK2 signaling"
XP_046421378.1	2	Reactome: R-HSA-6783310;MetaCyc: PWY-7511	"Fanconi Anemia Pathway";"Protein ubiquitination"
XP_046416833.1	14	MetaCyc: PWY-7417;KEGG: 00591+3.1.1.4;MetaCyc: PWY-7416;MetaCyc: PWY-8053;MetaCyc: PWY-7409;MetaCyc: PWY-7783;KEGG: 00592+3.1.1.4;Reactome: R-HSA-975634;KEGG: 00590+3.1.1.4;MetaCyc: PWY-6803;Reactome: R-HSA-1482788;KEGG: 00565+3.1.1.4;KEGG: 00564+3.1.1.4+3.1.1.5;MetaCyc: PWY-8051	"Phospholipid remodeling (phosphatidate, yeast)";"Linoleic acid metabolism";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Anandamide biosynthesis II";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Plasmalogen degradation";"alpha-Linolenic acid metabolism";"Retinoid metabolism and transport";"Arachidonic acid metabolism";"Phosphatidylcholine acyl editing";"Acyl chain remodelling of PC";"Ether lipid metabolism";"Glycerophospholipid metabolism";"Anandamide biosynthesis I"
XP_046427451.1	11	MetaCyc: PWY-3881;Reactome: R-HSA-4043916;MetaCyc: PWY-882;KEGG: 00520+5.3.1.8;MetaCyc: PWY-5659;MetaCyc: PWY-6992;MetaCyc: PWY-7456;MetaCyc: PWY-3861;Reactome: R-HSA-446205;MetaCyc: PWY-7586;KEGG: 00051+5.3.1.8	"Mannitol biosynthesis";"Defective MPI causes MPI-CDG (CDG-1b)";"L-ascorbate biosynthesis I (L-galactose pathway)";"Amino sugar and nucleotide sugar metabolism";"GDP-mannose biosynthesis";"1,5-anhydrofructose degradation";"Beta-(1,4)-mannan degradation";"Mannitol degradation II";"Synthesis of GDP-mannose";"Beta-1,4-d-mannosyl-n-acetyl-d-glucosamine degradation";"Fructose and mannose metabolism"
XP_046424565.1	17	Reactome: R-HSA-5358565;Reactome: R-HSA-6782135;Reactome: R-HSA-5696400;Reactome: R-HSA-174417;Reactome: R-HSA-174414;Reactome: R-HSA-69183;Reactome: R-HSA-174411;Reactome: R-HSA-5651801;Reactome: R-HSA-69166;Reactome: R-HSA-5685942;Reactome: R-HSA-174437;Reactome: R-HSA-5358606;Reactome: R-HSA-6782210;Reactome: R-HSA-5656169;Reactome: R-HSA-69091;Reactome: R-HSA-5696397;Reactome: R-HSA-110314	"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"Dual incision in TC-NER";"Dual Incision in GG-NER";"Telomere C-strand (Lagging Strand) Synthesis";"Processive synthesis on the C-strand of the telomere";"Processive synthesis on the lagging strand";"Polymerase switching on the C-strand of the telomere";"PCNA-Dependent Long Patch Base Excision Repair";"Removal of the Flap Intermediate";"HDR through Homologous Recombination (HRR)";"Removal of the Flap Intermediate from the C-strand";"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Termination of translesion DNA synthesis";"Polymerase switching";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Recognition of DNA damage by PCNA-containing replication complex"
XP_046435460.1	3	Reactome: R-HSA-212436;Reactome: R-HSA-1989781;Reactome: R-HSA-381340	"Generic Transcription Pathway";"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation"
XP_046430109.1	1	Reactome: R-HSA-6790901	"rRNA modification in the nucleus and cytosol"
XP_046411693.1	13	KEGG: 00603+3.2.1.52;KEGG: 00511+3.2.1.52;KEGG: 00604+3.2.1.52;Reactome: R-HSA-2022857;MetaCyc: PWY-7883;Reactome: R-HSA-1660662;Reactome: R-HSA-2024101;KEGG: 00520+3.2.1.52;KEGG: 00531+3.2.1.52;Reactome: R-HSA-2160916;MetaCyc: PWY-7822;KEGG: 00513+3.2.1.52;MetaCyc: PWY-6902	"Glycosphingolipid biosynthesis - globo and isoglobo series";"Other glycan degradation";"Glycosphingolipid biosynthesis - ganglio series";"Keratan sulfate degradation";"Anhydromuropeptides recycling II";"Glycosphingolipid metabolism";"CS/DS degradation";"Amino sugar and nucleotide sugar metabolism";"Glycosaminoglycan degradation";"Hyaluronan uptake and degradation";"Chitin degradation III (Serratia)";"Various types of N-glycan biosynthesis";"Chitin degradation II (Vibrio)"
XP_046417777.1	1	Reactome: R-HSA-2022377	"Metabolism of Angiotensinogen to Angiotensins"
XP_046412141.1	1	Reactome: R-HSA-9616222	"Transcriptional regulation of granulopoiesis"
XP_046423905.1	6	Reactome: R-HSA-429958;Reactome: R-HSA-380994;Reactome: R-HSA-450604;Reactome: R-HSA-450513;Reactome: R-HSA-6791226;Reactome: R-HSA-450385	"mRNA decay by 3' to 5' exoribonuclease";"ATF4 activates genes in response to endoplasmic reticulum stress";"KSRP (KHSRP) binds and destabilizes mRNA";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"Major pathway of rRNA processing in the nucleolus and cytosol";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA"
XP_046416869.1	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046410875.1	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
XP_046427315.1	3	Reactome: R-HSA-1660514;Reactome: R-HSA-1660516;Reactome: R-HSA-1660517	"Synthesis of PIPs at the Golgi membrane";"Synthesis of PIPs at the early endosome membrane";"Synthesis of PIPs at the late endosome membrane"
XP_046412839.1	5	KEGG: 00330+1.14.13.39;KEGG: 00220+1.14.13.39;Reactome: R-HSA-392154;MetaCyc: PWY-4983;Reactome: R-HSA-1222556	"Arginine and proline metabolism";"Arginine biosynthesis";"Nitric oxide stimulates guanylate cyclase";"Nitric oxide biosynthesis II (mammals)";"ROS and RNS production in phagocytes"
XP_046432854.1	8	Reactome: R-HSA-71336;Reactome: R-HSA-163754;Reactome: R-HSA-6791462;KEGG: 00030+2.2.1.2;Reactome: R-HSA-8950505;MetaCyc: PWY-1861;Reactome: R-HSA-6791055;MetaCyc: PWY-5723	"Pentose phosphate pathway";"Insulin effects increased synthesis of Xylulose-5-Phosphate";"TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P";"Pentose phosphate pathway";"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation";"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P";"Rubisco shunt"
XP_046425286.1	17	KEGG: 04150+2.7.11.1;Reactome: R-HSA-176187;Reactome: R-HSA-6796648;KEGG: 04151+2.7.11.1;Reactome: R-HSA-5693616;Reactome: R-HSA-6804756;KEGG: 04926+2.7.11.1;Reactome: R-HSA-69473;KEGG: 05163+2.7.11.1;Reactome: R-HSA-3371453;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;Reactome: R-HSA-5685938;Reactome: R-HSA-6783310;Reactome: R-HSA-1221632;Reactome: R-HSA-5693607;KEGG: 05165+2.7.11.1	"mTOR signaling pathway";"Activation of ATR in response to replication stress";"TP53 Regulates Transcription of DNA Repair Genes";"PI3K-Akt signaling pathway";"Presynaptic phase of homologous DNA pairing and strand exchange";"Regulation of TP53 Activity through Phosphorylation";"Relaxin signaling pathway";"G2/M DNA damage checkpoint";"Human cytomegalovirus infection";"Regulation of HSF1-mediated heat shock response";"Human immunodeficiency virus 1 infection";"Thermogenesis";"HDR through Single Strand Annealing (SSA)";"Fanconi Anemia Pathway";"Meiotic synapsis";"Processing of DNA double-strand break ends";"Human papillomavirus infection"
XP_046414955.1	1	Reactome: R-HSA-3295583	"TRP channels"
XP_046417597.1	6	Reactome: R-HSA-2173788;Reactome: R-HSA-8948751;Reactome: R-HSA-8939902;Reactome: R-HSA-983168;Reactome: R-HSA-8863795;MetaCyc: PWY-7511	"Downregulation of TGF-beta receptor signaling";"Regulation of PTEN stability and activity";"Regulation of RUNX2 expression and activity";"Antigen processing: Ubiquitination & Proteasome degradation";"Downregulation of ERBB2 signaling";"Protein ubiquitination"
XP_046420655.1	1	Reactome: R-HSA-6785631	"ERBB2 Regulates Cell Motility"
XP_046430144.1	4	Reactome: R-HSA-381771;Reactome: R-HSA-422085;Reactome: R-HSA-1799339;Reactome: R-HSA-400511	"Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)";"Synthesis, secretion, and deacylation of Ghrelin";"SRP-dependent cotranslational protein targeting to membrane";"Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)"
XP_046424264.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_046419186.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046432535.1	5	KEGG: 00561+3.2.1.22;KEGG: 00600+3.2.1.22;MetaCyc: PWY-6527;KEGG: 00052+3.2.1.22;KEGG: 00603+3.2.1.22	"Glycerolipid metabolism";"Sphingolipid metabolism";"Stachyose degradation";"Galactose metabolism";"Glycosphingolipid biosynthesis - globo and isoglobo series"
XP_046418728.1	16	Reactome: R-HSA-180585;Reactome: R-HSA-167287;Reactome: R-HSA-1234176;Reactome: R-HSA-167246;Reactome: R-HSA-8951664;Reactome: R-HSA-167238;Reactome: R-HSA-167200;Reactome: R-HSA-6796648;Reactome: R-HSA-674695;Reactome: R-HSA-167152;Reactome: R-HSA-167290;Reactome: R-HSA-75955;Reactome: R-HSA-983168;Reactome: R-HSA-9010553;Reactome: R-HSA-167243;Reactome: R-HSA-112382	"Vif-mediated degradation of APOBEC3G";"HIV elongation arrest and recovery";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Tat-mediated elongation of the HIV-1 transcript";"Neddylation";"Pausing and recovery of Tat-mediated HIV elongation";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Pre-transcription Events";"Formation of HIV elongation complex in the absence of HIV Tat";"Pausing and recovery of HIV elongation";"RNA Polymerase II Transcription Elongation";"Antigen processing: Ubiquitination & Proteasome degradation";"Regulation of expression of SLITs and ROBOs";"Tat-mediated HIV elongation arrest and recovery";"Formation of RNA Pol II elongation complex"
XP_046416830.1	14	MetaCyc: PWY-7409;MetaCyc: PWY-8053;MetaCyc: PWY-7416;KEGG: 00591+3.1.1.4;MetaCyc: PWY-7417;KEGG: 00564+3.1.1.4+3.1.1.5;MetaCyc: PWY-8051;Reactome: R-HSA-1482788;MetaCyc: PWY-6803;KEGG: 00565+3.1.1.4;Reactome: R-HSA-975634;KEGG: 00590+3.1.1.4;MetaCyc: PWY-7783;KEGG: 00592+3.1.1.4	"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Anandamide biosynthesis II";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Linoleic acid metabolism";"Phospholipid remodeling (phosphatidate, yeast)";"Glycerophospholipid metabolism";"Anandamide biosynthesis I";"Acyl chain remodelling of PC";"Phosphatidylcholine acyl editing";"Ether lipid metabolism";"Retinoid metabolism and transport";"Arachidonic acid metabolism";"Plasmalogen degradation";"alpha-Linolenic acid metabolism"
XP_046416518.1	27	Reactome: R-HSA-168271;Reactome: R-HSA-159227;Reactome: R-HSA-168333;Reactome: R-HSA-3301854;Reactome: R-HSA-5619107;Reactome: R-HSA-168276;Reactome: R-HSA-4615885;Reactome: R-HSA-191859;Reactome: R-HSA-180746;Reactome: R-HSA-159230;Reactome: R-HSA-5578749;Reactome: R-HSA-3371453;Reactome: R-HSA-180910;Reactome: R-HSA-170822;Reactome: R-HSA-3232142;Reactome: R-HSA-6784531;Reactome: R-HSA-4085377;Reactome: R-HSA-165054;Reactome: R-HSA-4551638;Reactome: R-HSA-9610379;Reactome: R-HSA-4570464;Reactome: R-HSA-168325;Reactome: R-HSA-1169408;Reactome: R-HSA-159231;Reactome: R-HSA-3108214;Reactome: R-HSA-9609690;Reactome: R-HSA-159236	"Transport of Ribonucleoproteins into the Host Nucleus";"Transport of the SLBP independent Mature mRNA";"NEP/NS2 Interacts with the Cellular Export Machinery";"Nuclear Pore Complex (NPC) Disassembly";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"NS1 Mediated Effects on Host Pathways";"SUMOylation of DNA replication proteins";"snRNP Assembly";"Nuclear import of Rev protein";"Transport of the SLBP Dependant Mature mRNA";"Transcriptional regulation by small RNAs";"Regulation of HSF1-mediated heat shock response";"Vpr-mediated nuclear import of PICs";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"SUMOylation of ubiquitinylation proteins";"tRNA processing in the nucleus";"SUMOylation of SUMOylation proteins";"Rev-mediated nuclear export of HIV RNA";"SUMOylation of chromatin organization proteins";"HCMV Late Events";"SUMOylation of RNA binding proteins";"Viral Messenger RNA Synthesis";"ISG15 antiviral mechanism";"Transport of Mature mRNA Derived from an Intronless Transcript";"SUMOylation of DNA damage response and repair proteins";"HCMV Early Events";"Transport of Mature mRNA derived from an Intron-Containing Transcript"
XP_046411446.1	1	Reactome: R-HSA-8949664	"Processing of SMDT1"
XP_046428887.1	20	MetaCyc: PWY-7288;MetaCyc: PWY-7340;MetaCyc: PWY-7574;MetaCyc: PWY-7337;MetaCyc: PWY-7007;MetaCyc: PWY-7854;MetaCyc: PWY-7606;MetaCyc: PWY-7726;KEGG: 00592+1.3.3.6;KEGG: 00640+1.3.3.6;MetaCyc: PWY-735;MetaCyc: PWY-6837;Reactome: R-HSA-9033241;KEGG: 00410+1.3.3.6;MetaCyc: PWY-5136;MetaCyc: PWY-7291;MetaCyc: PWY-7858;MetaCyc: PWY-6920;MetaCyc: PWY-7338;KEGG: 00071+1.3.3.6	"Fatty acid beta-oxidation VII (yeast peroxisome)";"9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast)";"Propanoyl-coa degradation II";"10-cis-heptadecenoyl-CoA degradation (yeast)";"Methyl ketone biosynthesis (engineered)";"Crotonyl-coa/ethylmalonyl-coa/hydroxybutyryl-coa cycle (engineered)";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"alpha-Linolenic acid metabolism";"Propanoate metabolism";"Jasmonic acid biosynthesis";"Fatty acid beta-oxidation V (unsaturated, odd number, di-isomerase-dependent)";"Peroxisomal protein import";"beta-Alanine metabolism";"Fatty acid beta-oxidation II (plant peroxisome)";"Oleate beta-oxidation (isomerase-dependent, yeast)";"(5Z)-dodecenoate biosynthesis II";"6-gingerol analog biosynthesis (engineered)";"10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast)";"Fatty acid degradation"
XP_046424464.1	1	Reactome: R-HSA-1483148	"Synthesis of PG"
XP_046410069.1	3	Reactome: R-HSA-9603798;Reactome: R-HSA-9033241;Reactome: R-HSA-8866654	"Class I peroxisomal membrane protein import";"Peroxisomal protein import";"E3 ubiquitin ligases ubiquitinate target proteins"
XP_046418269.1	7	Reactome: R-HSA-5626467;Reactome: R-HSA-141444;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813;Reactome: R-HSA-68877;Reactome: R-HSA-2500257;Reactome: R-HSA-5663220	"RHO GTPases activate IQGAPs";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids";"Mitotic Prometaphase";"Resolution of Sister Chromatid Cohesion";"RHO GTPases Activate Formins"
XP_046421537.1	5	KEGG: 00534+2.4.1.224+2.4.1.225;Reactome: R-HSA-3656237;Reactome: R-HSA-2022928;Reactome: R-HSA-3656253;MetaCyc: PWY-6558	"Glycosaminoglycan biosynthesis - heparan sulfate / heparin";"Defective EXT2 causes exostoses 2";"HS-GAG biosynthesis";"Defective EXT1 causes exostoses 1, TRPS2 and CHDS";"Heparan sulfate biosynthesis (late stages)"
XP_046425916.1	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
XP_046436294.1	7	Reactome: R-HSA-5620912;Reactome: R-HSA-380284;Reactome: R-HSA-8854518;Reactome: R-HSA-380259;Reactome: R-HSA-380320;Reactome: R-HSA-380270;Reactome: R-HSA-2565942	"Anchoring of the basal body to the plasma membrane";"Loss of proteins required for interphase microtubule organization from the centrosome";"AURKA Activation by TPX2";"Loss of Nlp from mitotic centrosomes";"Recruitment of NuMA to mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes";"Regulation of PLK1 Activity at G2/M Transition"
XP_046431168.1	7	MetaCyc: PWY-6922;MetaCyc: PWY-46;MetaCyc: PWY-4984;KEGG: 00330+3.5.3.1;MetaCyc: PWY-31;KEGG: 00220+3.5.3.1;Reactome: R-HSA-70635	"L-Ndelta-acetylornithine biosynthesis";"Putrescine biosynthesis III";"Urea cycle";"Arginine and proline metabolism";"Canavanine degradation";"Arginine biosynthesis";"Urea cycle"
XP_046431726.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046419636.1	1	Reactome: R-HSA-211897	"Cytochrome P450 - arranged by substrate type"
XP_046431912.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046430370.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046433237.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046429830.1	8	KEGG: 00524+2.7.1.1;KEGG: 00521+2.7.1.1;Reactome: R-HSA-70171;KEGG: 00051+2.7.1.1;KEGG: 00520+2.7.1.1;KEGG: 00010+2.7.1.1;KEGG: 00500+2.7.1.1;KEGG: 00052+2.7.1.1	"Neomycin, kanamycin and gentamicin biosynthesis";"Streptomycin biosynthesis";"Glycolysis";"Fructose and mannose metabolism";"Amino sugar and nucleotide sugar metabolism";"Glycolysis / Gluconeogenesis";"Starch and sucrose metabolism";"Galactose metabolism"
XP_046410714.1	2	Reactome: R-HSA-1236394;Reactome: R-HSA-977443	"Signaling by ERBB4";"GABA receptor activation"
XP_046421577.1	7	KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1	"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Relaxin signaling pathway";"Thermogenesis";"Human cytomegalovirus infection";"mTOR signaling pathway";"PI3K-Akt signaling pathway"
XP_046430942.1	1	Reactome: R-HSA-8854691	"Interleukin-20 family signaling"
XP_046421718.1	2	Reactome: R-HSA-2408522;Reactome: R-HSA-379716	"Selenoamino acid metabolism";"Cytosolic tRNA aminoacylation"
XP_046416659.1	1	Reactome: R-HSA-6794361	"Neurexins and neuroligins"
XP_046434843.1	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
XP_046434316.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_046412129.1	1	Reactome: R-HSA-9603798	"Class I peroxisomal membrane protein import"
XP_046432688.1	2	Reactome: R-HSA-445095;Reactome: R-HSA-5576892	"Interaction between L1 and Ankyrins";"Phase 0 - rapid depolarisation"
XP_046417144.1	3	Reactome: R-HSA-5657562;Reactome: R-HSA-70350;KEGG: 00051+2.7.1.3	"Essential fructosuria";"Fructose catabolism";"Fructose and mannose metabolism"
XP_046426972.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046436271.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046417915.1	3	Reactome: R-HSA-8856828;Reactome: R-HSA-6811440;Reactome: R-HSA-8856825	"Clathrin-mediated endocytosis";"Retrograde transport at the Trans-Golgi-Network";"Cargo recognition for clathrin-mediated endocytosis"
XP_046425109.1	2	Reactome: R-HSA-202433;Reactome: R-HSA-376176	"Generation of second messenger molecules";"Signaling by ROBO receptors"
XP_046432473.1	6	Reactome: R-HSA-400253;KEGG: 04660+3.1.3.16;Reactome: R-HSA-2173788;KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16;Reactome: R-HSA-163560	"Circadian Clock";"T cell receptor signaling pathway";"Downregulation of TGF-beta receptor signaling";"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Triglyceride catabolism"
XP_046434726.1	17	Reactome: R-HSA-167242;Reactome: R-HSA-674695;Reactome: R-HSA-6796648;Reactome: R-HSA-167200;Reactome: R-HSA-167290;Reactome: R-HSA-167152;KEGG: 05235+3.1.3.16;Reactome: R-HSA-75955;Reactome: R-HSA-112382;Reactome: R-HSA-167243;KEGG: 04660+3.1.3.16;Reactome: R-HSA-167158;Reactome: R-HSA-167287;Reactome: R-HSA-167246;Reactome: R-HSA-113418;KEGG: 04658+3.1.3.16;Reactome: R-HSA-167238	"Abortive elongation of HIV-1 transcript in the absence of Tat";"RNA Polymerase II Pre-transcription Events";"TP53 Regulates Transcription of DNA Repair Genes";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Pausing and recovery of HIV elongation";"Formation of HIV elongation complex in the absence of HIV Tat";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"RNA Polymerase II Transcription Elongation";"Formation of RNA Pol II elongation complex";"Tat-mediated HIV elongation arrest and recovery";"T cell receptor signaling pathway";"Formation of the HIV-1 Early Elongation Complex";"HIV elongation arrest and recovery";"Tat-mediated elongation of the HIV-1 transcript";"Formation of the Early Elongation Complex";"Th1 and Th2 cell differentiation";"Pausing and recovery of Tat-mediated HIV elongation"
XP_046434063.1	1	Reactome: R-HSA-1296061	"HCN channels"
XP_046412841.1	1	Reactome: R-HSA-216083	"Integrin cell surface interactions"
XP_046417807.1	5	Reactome: R-HSA-3247509;Reactome: R-HSA-3214858;Reactome: R-HSA-1266695;Reactome: R-HSA-201722;Reactome: R-HSA-8939243	"Chromatin modifying enzymes";"RMTs methylate histone arginines";"Interleukin-7 signaling";"Formation of the beta-catenin:TCF transactivating complex";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"
XP_046436579.1	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
XP_046426165.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_046432703.1	1	Reactome: R-HSA-381753	"Olfactory Signaling Pathway"
XP_046429190.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046415126.1	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
XP_046435693.1	1	MetaCyc: PWY-6308	"L-cysteine biosynthesis II (tRNA-dependent)"
XP_046413638.1	2	Reactome: R-HSA-6804756;Reactome: R-HSA-8854518	"Regulation of TP53 Activity through Phosphorylation";"AURKA Activation by TPX2"
XP_046425755.1	3	Reactome: R-HSA-8854691;Reactome: R-HSA-6785807;KEGG: 04660+2.7.10.2	"Interleukin-20 family signaling";"Interleukin-4 and Interleukin-13 signaling";"T cell receptor signaling pathway"
XP_046426174.1	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_046414773.1	8	Reactome: R-HSA-6782210;Reactome: R-HSA-6804757;Reactome: R-HSA-6781823;Reactome: R-HSA-5689880;Reactome: R-HSA-8866652;Reactome: R-HSA-8948747;Reactome: R-HSA-6781827;Reactome: R-HSA-6782135	"Gap-filling DNA repair synthesis and ligation in TC-NER";"Regulation of TP53 Degradation";"Formation of TC-NER Pre-Incision Complex";"Ub-specific processing proteases";"Synthesis of active ubiquitin: roles of E1 and E2 enzymes";"Regulation of PTEN localization";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Dual incision in TC-NER"
XP_046434767.1	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
XP_046415145.1	2	Reactome: R-HSA-196741;Reactome: R-HSA-3359473	"Cobalamin (Cbl, vitamin B12) transport and metabolism";"Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD"
XP_046425878.1	3	Reactome: R-HSA-5578775;Reactome: R-HSA-936837;Reactome: R-HSA-418359	"Ion homeostasis";"Ion transport by P-type ATPases";"Reduction of cytosolic Ca++ levels"
XP_046413612.1	1	Reactome: R-HSA-6809371	"Formation of the cornified envelope"
XP_046433271.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046423999.1	3	Reactome: R-HSA-6807878;Reactome: R-HSA-162658;Reactome: R-HSA-204005	"COPI-mediated anterograde transport";"Golgi Cisternae Pericentriolar Stack Reorganization";"COPII-mediated vesicle transport"
XP_046432245.1	3	Reactome: R-HSA-392154;Reactome: R-HSA-445355;KEGG: 00230+4.6.1.2	"Nitric oxide stimulates guanylate cyclase";"Smooth Muscle Contraction";"Purine metabolism"
XP_046420423.1	4	Reactome: R-HSA-5693554;Reactome: R-HSA-5685942;Reactome: R-HSA-5693579;Reactome: R-HSA-5693568	"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"HDR through Homologous Recombination (HRR)";"Homologous DNA Pairing and Strand Exchange";"Resolution of D-loop Structures through Holliday Junction Intermediates"
XP_046427904.1	1	Reactome: R-HSA-1660661	"Sphingolipid de novo biosynthesis"
XP_046415722.1	1	Reactome: R-HSA-5576886	"Phase 4 - resting membrane potential"
XP_046412914.1	4	KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16;Reactome: R-HSA-6807505	"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"RNA polymerase II transcribes snRNA genes"
XP_046411472.1	8	Reactome: R-HSA-141444;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813;Reactome: R-HSA-4615885;Reactome: R-HSA-68877;Reactome: R-HSA-2500257;Reactome: R-HSA-5663220;Reactome: R-HSA-165054	"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids";"SUMOylation of DNA replication proteins";"Mitotic Prometaphase";"Resolution of Sister Chromatid Cohesion";"RHO GTPases Activate Formins";"Rev-mediated nuclear export of HIV RNA"
XP_046412975.1	8	MetaCyc: PWY-7922;Reactome: R-HSA-5173105;Reactome: R-HSA-5083629;MetaCyc: PWY-7921;KEGG: 00514+2.4.1.109;KEGG: 00515+2.4.1.109;MetaCyc: PWY-7979;Reactome: R-HSA-5083633	"Protein O-mannosylation II (mammals, core M1 and core M2)";"O-linked glycosylation";"Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2";"Protein O-mannosylation I (yeast)";"Other types of O-glycan biosynthesis";"Mannose type O-glycan biosynthesis";"Protein O-mannosylation III (mammals, core M3)";"Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1"
XP_046422001.1	2	Reactome: R-HSA-1296052;Reactome: R-HSA-418457	"Ca2+ activated K+ channels";"cGMP effects"
XP_046435884.1	3	Reactome: R-HSA-8963901;Reactome: R-HSA-6807878;Reactome: R-HSA-445095	"Chylomicron remodeling";"COPI-mediated anterograde transport";"Interaction between L1 and Ankyrins"
XP_046412501.1	4	KEGG: 00260+1.2.1.8+1.1.99.1;Reactome: R-HSA-6798163;MetaCyc: PWY-7494;MetaCyc: PWY-3722	"Glycine, serine and threonine metabolism";"Choline catabolism";"Choline degradation IV";"Glycine betaine biosynthesis II (Gram-positive bacteria)"
XP_046429488.1	5	MetaCyc: PWY-7560;MetaCyc: PWY-6892;KEGG: 00730+2.2.1.7;MetaCyc: PWY-6891;KEGG: 00900+2.2.1.7	"Methylerythritol phosphate pathway II";"Thiazole biosynthesis I (facultative anaerobic bacteria)";"Thiamine metabolism";"Thiazole biosynthesis II (aerobic bacteria)";"Terpenoid backbone biosynthesis"
XP_046435276.1	3	KEGG: 00730+3.1.3.2;KEGG: 00740+3.1.3.2;MetaCyc: PWY-6348	"Thiamine metabolism";"Riboflavin metabolism";"Phosphate acquisition"
XP_046436505.1	2	Reactome: R-HSA-8853383;KEGG: 00511+3.2.1.24	"Lysosomal oligosaccharide catabolism";"Other glycan degradation"
XP_046413586.1	10	MetaCyc: PWY-7385;MetaCyc: PWY-1042;KEGG: 00680+2.7.1.11;KEGG: 00010+2.7.1.11;Reactome: R-HSA-70171;MetaCyc: PWY-1861;MetaCyc: PWY-5484;KEGG: 00052+2.7.1.11;KEGG: 00051+2.7.1.11;KEGG: 00030+2.7.1.11	"1,3-propanediol biosynthesis (engineered)";"Glycolysis IV (plant cytosol)";"Methane metabolism";"Glycolysis / Gluconeogenesis";"Glycolysis";"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"Glycolysis II (from fructose 6-phosphate)";"Galactose metabolism";"Fructose and mannose metabolism";"Pentose phosphate pathway"
XP_046436681.1	12	Reactome: R-HSA-3371497;Reactome: R-HSA-6807878;Reactome: R-HSA-5663220;Reactome: R-HSA-2500257;Reactome: R-HSA-9648025;Reactome: R-HSA-141444;Reactome: R-HSA-9609690;Reactome: R-HSA-68877;Reactome: R-HSA-2467813;Reactome: R-HSA-6811436;Reactome: R-HSA-9646399;Reactome: R-HSA-2132295	"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-mediated anterograde transport";"RHO GTPases Activate Formins";"Resolution of Sister Chromatid Cohesion";"EML4 and NUDC in mitotic spindle formation";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"HCMV Early Events";"Mitotic Prometaphase";"Separation of Sister Chromatids";"COPI-independent Golgi-to-ER retrograde traffic";"Aggrephagy";"MHC class II antigen presentation"
XP_046420658.1	1	Reactome: R-HSA-6785631	"ERBB2 Regulates Cell Motility"
XP_046433591.1	2	Reactome: R-HSA-425397;Reactome: R-HSA-5619061	"Transport of vitamins, nucleosides, and related molecules";"Defective SLC33A1 causes spastic paraplegia 42 (SPG42)"
XP_046416885.1	13	KEGG: 00230+1.17.4.1;KEGG: 00480+1.17.4.1;MetaCyc: PWY-7226;MetaCyc: PWY-7198;MetaCyc: PWY-7227;MetaCyc: PWY-7220;KEGG: 00983+1.17.4.1;MetaCyc: PWY-7222;MetaCyc: PWY-6545;KEGG: 00240+1.17.4.1;Reactome: R-HSA-499943;MetaCyc: PWY-7210;MetaCyc: PWY-7184	"Purine metabolism";"Glutathione metabolism";"Guanosine deoxyribonucleotides de novo biosynthesis I";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Adenosine deoxyribonucleotides de novo biosynthesis";"Adenosine deoxyribonucleotides de novo biosynthesis II";"Drug metabolism - other enzymes";"Guanosine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Pyrimidine metabolism";"Interconversion of nucleotide di- and triphosphates";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Pyrimidine deoxyribonucleotides de novo biosynthesis I"
XP_046428150.1	16	Reactome: R-HSA-975957;Reactome: R-HSA-156902;Reactome: R-HSA-72649;Reactome: R-HSA-72764;Reactome: R-HSA-72689;Reactome: R-HSA-192823;Reactome: R-HSA-72695;Reactome: R-HSA-1799339;Reactome: R-HSA-6791226;Reactome: R-HSA-72702;Reactome: R-HSA-975956;Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-72706;Reactome: R-HSA-2408557	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Peptide chain elongation";"Translation initiation complex formation";"Eukaryotic Translation Termination";"Formation of a pool of free 40S subunits";"Viral mRNA Translation";"Formation of the ternary complex, and subsequently, the 43S complex";"SRP-dependent cotranslational protein targeting to membrane";"Major pathway of rRNA processing in the nucleolus and cytosol";"Ribosomal scanning and start codon recognition";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Selenocysteine synthesis"
XP_046428736.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046412854.1	2	KEGG: 00230+2.7.4.8;MetaCyc: PWY-7221	"Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis"
XP_046415963.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046427389.1	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_046431968.1	4	Reactome: R-HSA-72764;Reactome: R-HSA-975956;Reactome: R-HSA-9010553;Reactome: R-HSA-975957	"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
XP_046423724.1	2	Reactome: R-HSA-71336;KEGG: 00710+2.7.1.14	"Pentose phosphate pathway";"Carbon fixation in photosynthetic organisms"
XP_046431342.1	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
XP_046433838.1	1	Reactome: R-HSA-1474228	"Degradation of the extracellular matrix"
XP_046430838.1	33	Reactome: R-HSA-191859;Reactome: R-HSA-159230;Reactome: R-HSA-4615885;Reactome: R-HSA-5619107;Reactome: R-HSA-168276;Reactome: R-HSA-168271;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813;Reactome: R-HSA-1169408;Reactome: R-HSA-159231;Reactome: R-HSA-3108214;Reactome: R-HSA-9610379;Reactome: R-HSA-4551638;Reactome: R-HSA-3232142;Reactome: R-HSA-2500257;Reactome: R-HSA-3371453;Reactome: R-HSA-180746;Reactome: R-HSA-5578749;Reactome: R-HSA-68877;Reactome: R-HSA-3301854;Reactome: R-HSA-168333;Reactome: R-HSA-159227;Reactome: R-HSA-5663220;Reactome: R-HSA-141444;Reactome: R-HSA-159236;Reactome: R-HSA-168325;Reactome: R-HSA-9609690;Reactome: R-HSA-4570464;Reactome: R-HSA-165054;Reactome: R-HSA-4085377;Reactome: R-HSA-6784531;Reactome: R-HSA-170822;Reactome: R-HSA-180910	"snRNP Assembly";"Transport of the SLBP Dependant Mature mRNA";"SUMOylation of DNA replication proteins";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"NS1 Mediated Effects on Host Pathways";"Transport of Ribonucleoproteins into the Host Nucleus";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids";"ISG15 antiviral mechanism";"Transport of Mature mRNA Derived from an Intronless Transcript";"SUMOylation of DNA damage response and repair proteins";"HCMV Late Events";"SUMOylation of chromatin organization proteins";"SUMOylation of ubiquitinylation proteins";"Resolution of Sister Chromatid Cohesion";"Regulation of HSF1-mediated heat shock response";"Nuclear import of Rev protein";"Transcriptional regulation by small RNAs";"Mitotic Prometaphase";"Nuclear Pore Complex (NPC) Disassembly";"NEP/NS2 Interacts with the Cellular Export Machinery";"Transport of the SLBP independent Mature mRNA";"RHO GTPases Activate Formins";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Viral Messenger RNA Synthesis";"HCMV Early Events";"SUMOylation of RNA binding proteins";"Rev-mediated nuclear export of HIV RNA";"SUMOylation of SUMOylation proteins";"tRNA processing in the nucleus";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Vpr-mediated nuclear import of PICs"
XP_046432199.1	4	Reactome: R-HSA-445095;Reactome: R-HSA-375165;Reactome: R-HSA-6807878;Reactome: R-HSA-5673001	"Interaction between L1 and Ankyrins";"NCAM signaling for neurite out-growth";"COPI-mediated anterograde transport";"RAF/MAP kinase cascade"
XP_046417815.1	4	Reactome: R-HSA-176187;Reactome: R-HSA-69205;Reactome: R-HSA-176974;Reactome: R-HSA-68962	"Activation of ATR in response to replication stress";"G1/S-Specific Transcription";"Unwinding of DNA";"Activation of the pre-replicative complex"
XP_046426935.1	2	KEGG: 00561+2.7.1.30;MetaCyc: PWY-4261	"Glycerolipid metabolism";"Glycerol degradation I"
XP_046434995.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046422293.1	1	Reactome: R-HSA-191273	"Cholesterol biosynthesis"
XP_046431237.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-5628897	"Respiratory electron transport";"TP53 Regulates Metabolic Genes"
XP_046425470.1	2	Reactome: R-HSA-380270;Reactome: R-HSA-380320	"Recruitment of mitotic centrosome proteins and complexes";"Recruitment of NuMA to mitotic centrosomes"
XP_046412870.1	3	Reactome: R-HSA-75109;KEGG: 00561+2.7.1.30;MetaCyc: PWY-4261	"Triglyceride biosynthesis";"Glycerolipid metabolism";"Glycerol degradation I"
XP_046420243.1	20	KEGG: 00660+6.2.1.5;MetaCyc: PWY-5392;MetaCyc: PWY-5913;KEGG: 00640+6.2.1.5;KEGG: 00020+6.2.1.5;Reactome: R-HSA-71403;MetaCyc: PWY-7384;MetaCyc: PWY-5690;MetaCyc: PWY-5172;Reactome: R-HSA-163765;KEGG: 00720+6.2.1.5;MetaCyc: PWY-5537;Reactome: R-HSA-1268020;MetaCyc: PWY-6969;MetaCyc: PWY-5538;MetaCyc: PWY-6728;Reactome: R-HSA-6798695;Reactome: R-HSA-75105;KEGG: 00020+2.3.3.8;KEGG: 00720+2.3.3.8	"C5-Branched dibasic acid metabolism";"Reductive TCA cycle II";"Partial TCA cycle (obligate autotrophs)";"Propanoate metabolism";"Citrate cycle (TCA cycle)";"Citric acid cycle (TCA cycle)";"Anaerobic energy metabolism (invertebrates, mitochondrial)";"TCA cycle II (plants and fungi)";"Acetyl-coa biosynthesis III (from citrate)";"ChREBP activates metabolic gene expression";"Carbon fixation pathways in prokaryotes";"Pyruvate fermentation to acetate V";"Mitochondrial protein import";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Pyruvate fermentation to acetate VI";"Methylaspartate cycle";"Neutrophil degranulation";"Fatty acyl-CoA biosynthesis";"Citrate cycle (TCA cycle)";"Carbon fixation pathways in prokaryotes"
XP_046425456.1	3	Reactome: R-HSA-8939243;Reactome: R-HSA-2559580;Reactome: R-HSA-8943724	"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"Oxidative Stress Induced Senescence";"Regulation of PTEN gene transcription"
XP_046416854.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_046416154.1	1	Reactome: R-HSA-70221	"Glycogen breakdown (glycogenolysis)"
XP_046416714.1	6	Reactome: R-HSA-4641265;Reactome: R-HSA-201722;Reactome: R-HSA-8951430;Reactome: R-HSA-4411364;Reactome: R-HSA-4086398;Reactome: R-HSA-3769402	"Repression of WNT target genes";"Formation of the beta-catenin:TCF transactivating complex";"RUNX3 regulates WNT signaling";"Binding of TCF/LEF:CTNNB1 to target gene promoters";"Ca2+ pathway";"Deactivation of the beta-catenin transactivating complex"
XP_046434851.1	1	Reactome: R-HSA-418594	"G alpha (i) signalling events"
XP_046418541.1	4	KEGG: 00640+4.1.1.9;Reactome: R-HSA-9033241;Reactome: R-HSA-390247;KEGG: 00410+4.1.1.9	"Propanoate metabolism";"Peroxisomal protein import";"Beta-oxidation of very long chain fatty acids";"beta-Alanine metabolism"
XP_046434309.1	1	Reactome: R-HSA-6802952	"Signaling by BRAF and RAF fusions"
XP_046430247.1	7	Reactome: R-HSA-380320;Reactome: R-HSA-380270;Reactome: R-HSA-2565942;Reactome: R-HSA-8854518;Reactome: R-HSA-380259;Reactome: R-HSA-380284;Reactome: R-HSA-5620912	"Recruitment of NuMA to mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes";"Regulation of PLK1 Activity at G2/M Transition";"AURKA Activation by TPX2";"Loss of Nlp from mitotic centrosomes";"Loss of proteins required for interphase microtubule organization from the centrosome";"Anchoring of the basal body to the plasma membrane"
XP_046419061.1	1	Reactome: R-HSA-5658442	"Regulation of RAS by GAPs"
XP_046428711.1	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
XP_046409546.1	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276	"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination"
XP_046424690.1	3	Reactome: R-HSA-749476;Reactome: R-HSA-76071;Reactome: R-HSA-6807505	"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA polymerase II transcribes snRNA genes"
XP_046427480.1	2	Reactome: R-HSA-5576893;Reactome: R-HSA-5576892	"Phase 2 - plateau phase";"Phase 0 - rapid depolarisation"
XP_046414760.1	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6784531	"Major pathway of rRNA processing in the nucleolus and cytosol";"tRNA processing in the nucleus"
XP_046434977.1	1	Reactome: R-HSA-390651	"Dopamine receptors"
XP_046427010.1	1	KEGG: 00230+4.6.1.2	"Purine metabolism"
XP_046432709.1	2	Reactome: R-HSA-69273;Reactome: R-HSA-8862803	"Cyclin A/B1/B2 associated events during G2/M transition";"Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models"
XP_046421868.1	7	KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04926+2.7.11.1	"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Thermogenesis";"Human cytomegalovirus infection";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Relaxin signaling pathway"
XP_046434462.1	1	Reactome: R-HSA-5662702	"Melanin biosynthesis"
XP_046419524.1	3	Reactome: R-HSA-3000157;Reactome: R-HSA-8874081;Reactome: R-HSA-3000171	"Laminin interactions";"MET activates PTK2 signaling";"Non-integrin membrane-ECM interactions"
XP_046426119.1	1	Reactome: R-HSA-5658442	"Regulation of RAS by GAPs"
XP_046422705.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_046413114.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_046435101.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046432904.1	1	Reactome: R-HSA-110362	"POLB-Dependent Long Patch Base Excision Repair"
XP_046430190.1	2	Reactome: R-HSA-8951671;Reactome: R-HSA-2032785	"RUNX3 regulates YAP1-mediated transcription";"YAP1- and WWTR1 (TAZ)-stimulated gene expression"
XP_046418120.1	6	KEGG: 00531+3.2.1.23;KEGG: 00511+3.2.1.23;KEGG: 00600+3.2.1.23;MetaCyc: PWY-6807;KEGG: 00052+3.2.1.23;KEGG: 00604+3.2.1.23	"Glycosaminoglycan degradation";"Other glycan degradation";"Sphingolipid metabolism";"Xyloglucan degradation II (exoglucanase)";"Galactose metabolism";"Glycosphingolipid biosynthesis - ganglio series"
XP_046430208.1	2	Reactome: R-HSA-3928665;Reactome: R-HSA-2682334	"EPH-ephrin mediated repulsion of cells";"EPH-Ephrin signaling"
XP_046428845.1	1	Reactome: R-HSA-6799198	"Complex I biogenesis"
XP_046412656.1	4	Reactome: R-HSA-2644606;Reactome: R-HSA-2122947;Reactome: R-HSA-2894862;Reactome: R-HSA-350054	"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH1 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Notch-HLH transcription pathway"
XP_046430933.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_046423597.1	3	Reactome: R-HSA-381426;Reactome: R-HSA-8957275;Reactome: R-HSA-381038	"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"Post-translational protein phosphorylation";"XBP1(S) activates chaperone genes"
XP_046413403.1	16	Reactome: R-HSA-70171;MetaCyc: PWY-7124;MetaCyc: PWY-6142;MetaCyc: PWY-5723;MetaCyc: PWY-6886;KEGG: 00680+4.2.1.11;MetaCyc: PWY-5484;MetaCyc: PWY-7003;MetaCyc: PWY-1042;KEGG: 00010+4.2.1.11;MetaCyc: PWY-2221;MetaCyc: PWY-8004;MetaCyc: PWY-7218;MetaCyc: PWY-1622;MetaCyc: PWY-6901;Reactome: R-HSA-70263	"Glycolysis";"Ethylene biosynthesis V (engineered)";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Rubisco shunt";"1-butanol autotrophic biosynthesis (engineered)";"Methane metabolism";"Glycolysis II (from fructose 6-phosphate)";"Glycerol degradation to butanol";"Glycolysis IV (plant cytosol)";"Glycolysis / Gluconeogenesis";"Entner-Doudoroff pathway III (semi-phosphorylative)";"Entner-Doudoroff pathway I";"Photosynthetic 3-hydroxybutanoate biosynthesis (engineered)";"Formaldehyde assimilation I (serine pathway)";"Superpathway of glucose and xylose degradation";"Gluconeogenesis"
XP_046427202.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046432459.1	4	MetaCyc: PWY-5188;Reactome: R-HSA-189451;MetaCyc: PWY-5189;KEGG: 00860+4.2.1.75	"Tetrapyrrole biosynthesis I (from glutamate)";"Heme biosynthesis";"Tetrapyrrole biosynthesis II (from glycine)";"Porphyrin and chlorophyll metabolism"
XP_046413376.1	3	Reactome: R-HSA-73843;KEGG: 00030+2.7.6.1;KEGG: 00230+2.7.6.1	"5-Phosphoribose 1-diphosphate biosynthesis";"Pentose phosphate pathway";"Purine metabolism"
XP_046427169.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046421881.1	3	Reactome: R-HSA-8939902;Reactome: R-HSA-6785807;Reactome: R-HSA-8878166	"Regulation of RUNX2 expression and activity";"Interleukin-4 and Interleukin-13 signaling";"Transcriptional regulation by RUNX2"
XP_046431057.1	3	Reactome: R-HSA-375276;Reactome: R-HSA-416476;Reactome: R-HSA-418594	"Peptide ligand-binding receptors";"G alpha (q) signalling events";"G alpha (i) signalling events"
XP_046428902.1	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
XP_046428512.1	1	KEGG: 00970+6.3.5.7	"Aminoacyl-tRNA biosynthesis"
XP_046413230.1	1	Reactome: R-HSA-70221	"Glycogen breakdown (glycogenolysis)"
XP_046423483.1	3	Reactome: R-HSA-429947;Reactome: R-HSA-6804115;Reactome: R-HSA-5617472	"Deadenylation of mRNA";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Activation of anterior HOX genes in hindbrain development during early embryogenesis"
XP_046417102.1	6	MetaCyc: PWY-7782;MetaCyc: PWY-5884;MetaCyc: PWY-7656;KEGG: 00073+1.2.1.84;Reactome: R-HSA-9640463;MetaCyc: PWY-6733	"Plasmalogen biosynthesis";"Wax esters biosynthesis I";"Spodoptera littoralis pheromone biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax biosynthesis";"Sporopollenin precursors biosynthesis"
XP_046416446.1	1	Reactome: R-HSA-2564830	"Cytosolic iron-sulfur cluster assembly"
XP_046424138.1	6	Reactome: R-HSA-434316;Reactome: R-HSA-418592;Reactome: R-HSA-399997;Reactome: R-HSA-428930;Reactome: R-HSA-456926;Reactome: R-HSA-416476	"Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion";"ADP signalling through P2Y purinoceptor 1";"Acetylcholine regulates insulin secretion";"Thromboxane signalling through TP receptor";"Thrombin signalling through proteinase activated receptors (PARs)";"G alpha (q) signalling events"
XP_046423732.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_046431951.1	12	KEGG: 00230+2.7.1.25;MetaCyc: PWY-5340;KEGG: 00230+2.7.7.4;MetaCyc: PWY-5278;KEGG: 00261+2.7.7.4;KEGG: 00920+2.7.1.25;Reactome: R-HSA-2408550;KEGG: 00450+2.7.7.4;KEGG: 00920+2.7.7.4;MetaCyc: PWY-6932;MetaCyc: PWY-6683;Reactome: R-HSA-174362	"Purine metabolism";"Sulfate activation for sulfonation";"Purine metabolism";"Sulfite oxidation III";"Monobactam biosynthesis";"Sulfur metabolism";"Metabolism of ingested H2SeO4 and H2SeO3 into H2Se";"Selenocompound metabolism";"Sulfur metabolism";"Selenate reduction";"Assimilatory sulfate reduction III";"Transport and synthesis of PAPS"
XP_046421900.1	3	KEGG: 00860+2.5.1.141;Reactome: R-HSA-189451;MetaCyc: PWY-7856	"Porphyrin and chlorophyll metabolism";"Heme biosynthesis";"Heme a biosynthesis"
XP_046411901.1	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840	"Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation"
XP_046423537.1	2	Reactome: R-HSA-917729;Reactome: R-HSA-9610379	"Endosomal Sorting Complex Required For Transport (ESCRT)";"HCMV Late Events"
XP_046418278.1	1	Reactome: R-HSA-418886	"Netrin mediated repulsion signals"
XP_046421951.1	2	Reactome: R-HSA-1296052;Reactome: R-HSA-418457	"Ca2+ activated K+ channels";"cGMP effects"
XP_046430052.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046409971.1	2	Reactome: R-HSA-416476;Reactome: R-HSA-388479	"G alpha (q) signalling events";"Vasopressin-like receptors"
XP_046412339.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_046421272.1	1	Reactome: R-HSA-425561	"Sodium/Calcium exchangers"
XP_046429518.1	1	Reactome: R-HSA-419771	"Opsins"
XP_046410803.1	3	Reactome: R-HSA-159236;Reactome: R-HSA-72187;Reactome: R-HSA-73856	"Transport of Mature mRNA derived from an Intron-Containing Transcript";"mRNA 3'-end processing";"RNA Polymerase II Transcription Termination"
XP_046418911.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_046410610.1	17	Reactome: R-HSA-192823;Reactome: R-HSA-72689;Reactome: R-HSA-1799339;Reactome: R-HSA-72695;Reactome: R-HSA-975957;Reactome: R-HSA-72649;Reactome: R-HSA-72764;Reactome: R-HSA-156902;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-9633012;Reactome: R-HSA-72706;Reactome: R-HSA-2408557;Reactome: R-HSA-6790901;Reactome: R-HSA-6791226;Reactome: R-HSA-975956;Reactome: R-HSA-72702	"Viral mRNA Translation";"Formation of a pool of free 40S subunits";"SRP-dependent cotranslational protein targeting to membrane";"Formation of the ternary complex, and subsequently, the 43S complex";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Translation initiation complex formation";"Eukaryotic Translation Termination";"Peptide chain elongation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Selenocysteine synthesis";"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Ribosomal scanning and start codon recognition"
XP_046427762.1	182	Reactome: R-HSA-2672351;Reactome: R-HSA-2173788;Reactome: R-HSA-2559582;Reactome: R-HSA-5654733;Reactome: R-HSA-9636383;Reactome: R-HSA-6804756;Reactome: R-HSA-175474;Reactome: R-HSA-68949;Reactome: R-HSA-400253;Reactome: R-HSA-5676590;Reactome: R-HSA-6807004;Reactome: R-HSA-5358346;Reactome: R-HSA-1295596;Reactome: R-HSA-211733;Reactome: R-HSA-174490;Reactome: R-HSA-5610780;Reactome: R-HSA-5610783;Reactome: R-HSA-1234176;Reactome: R-HSA-180534;Reactome: R-HSA-6781827;Reactome: R-HSA-5696400;Reactome: R-HSA-5357905;Reactome: R-HSA-2979096;Reactome: R-HSA-174048;Reactome: R-HSA-68827;Reactome: R-HSA-5654732;Reactome: R-HSA-5689603;Reactome: R-HSA-5689896;Reactome: R-HSA-9637628;Reactome: R-HSA-2173795;Reactome: R-HSA-174113;Reactome: R-HSA-8854050;Reactome: R-HSA-6781823;Reactome: R-HSA-917937;Reactome: R-HSA-6791226;Reactome: R-HSA-937041;Reactome: R-HSA-5656169;Reactome: R-HSA-8939902;Reactome: R-HSA-9033241;Reactome: R-HSA-72706;Reactome: R-HSA-2691232;Reactome: R-HSA-5607761;Reactome: R-HSA-8866654;Reactome: R-HSA-5684264;Reactome: R-HSA-180585;Reactome: R-HSA-5675221;Reactome: R-HSA-72764;Reactome: R-HSA-162588;Reactome: R-HSA-4641257;Reactome: R-HSA-5689880;Reactome: R-HSA-6804760;Reactome: R-HSA-69541;Reactome: R-HSA-195253;Reactome: R-HSA-5689901;Reactome: R-HSA-975110;Reactome: R-HSA-901032;Reactome: R-HSA-9014325;Reactome: R-HSA-2122948;Reactome: R-HSA-1169091;Reactome: R-HSA-9604323;Reactome: R-HSA-937072;Reactome: R-HSA-69601;Reactome: R-HSA-9633012;Reactome: R-HSA-4641258;Reactome: R-HSA-5632684;Reactome: R-HSA-209560;Reactome: R-HSA-2173791;Reactome: R-HSA-8849469;Reactome: R-HSA-6782210;Reactome: R-HSA-72689;Reactome: R-HSA-209543;Reactome: R-HSA-937042;Reactome: R-HSA-72695;Reactome: R-HSA-9020702;Reactome: R-HSA-1169408;Reactome: R-HSA-8948747;Reactome: R-HSA-2559585;Reactome: R-HSA-936440;Reactome: R-HSA-5696394;Reactome: R-HSA-2173796;Reactome: R-HSA-156827;Reactome: R-HSA-5696397;Reactome: R-HSA-110314;Reactome: R-HSA-156902;Reactome: R-HSA-5357956;Reactome: R-HSA-6782135;Reactome: R-HSA-75815;Reactome: R-HSA-2644606;Reactome: R-HSA-5689877;Reactome: R-HSA-8856825;Reactome: R-HSA-9615710;Reactome: R-HSA-8875360;Reactome: R-HSA-2559580;Reactome: R-HSA-2871837;Reactome: R-HSA-174178;Reactome: R-HSA-9013973;Reactome: R-HSA-72702;Reactome: R-HSA-5362768;Reactome: R-HSA-69017;Reactome: R-HSA-9613829;Reactome: R-HSA-4641263;Reactome: R-HSA-8941858;Reactome: R-HSA-5656121;Reactome: R-HSA-532668;Reactome: R-HSA-975957;Reactome: R-HSA-8866652;Reactome: R-HSA-8852276;Reactome: R-HSA-2565942;Reactome: R-HSA-912631;Reactome: R-HSA-187577;Reactome: R-HSA-5607764;Reactome: R-HSA-445989;Reactome: R-HSA-168638;Reactome: R-HSA-1236382;Reactome: R-HSA-5675482;Reactome: R-HSA-1799339;Reactome: R-HSA-201681;Reactome: R-HSA-2467813;Reactome: R-HSA-5205685;Reactome: R-HSA-9013507;Reactome: R-HSA-5696395;Reactome: R-HSA-975144;Reactome: R-HSA-174184;Reactome: R-HSA-975163;Reactome: R-HSA-5658442;Reactome: R-HSA-179409;Reactome: R-HSA-8876493;Reactome: R-HSA-110312;Reactome: R-HSA-8939236;Reactome: R-HSA-1358803;Reactome: R-HSA-168928;Reactome: R-HSA-192823;Reactome: R-HSA-5685942;Reactome: R-HSA-5693607;Reactome: R-HSA-382556;Reactome: R-HSA-975956;Reactome: R-HSA-5654727;Reactome: R-HSA-5654726;Reactome: R-HSA-9010553;Reactome: R-HSA-5668541;Reactome: R-HSA-2408557;Reactome: R-HSA-450408;Reactome: R-HSA-1236974;Reactome: R-HSA-182971;Reactome: R-HSA-69481;Reactome: R-HSA-977225;Reactome: R-HSA-8948751;Reactome: R-HSA-8863795;Reactome: R-HSA-3134975;Reactome: R-HSA-5687128;Reactome: R-HSA-2122947;Reactome: R-HSA-9645460;Reactome: R-HSA-205043;Reactome: R-HSA-6804757;Reactome: R-HSA-2894862;Reactome: R-HSA-917729;Reactome: R-HSA-174154;Reactome: R-HSA-5655862;Reactome: R-HSA-168927;Reactome: R-HSA-983168;Reactome: R-HSA-5693565;Reactome: R-HSA-69231;Reactome: R-HSA-9646399;Reactome: R-HSA-450302;Reactome: R-HSA-3785653;Reactome: R-HSA-6783310;Reactome: R-HSA-8856828;Reactome: R-HSA-5610785;Reactome: R-HSA-3769402;Reactome: R-HSA-5678895;Reactome: R-HSA-3322077;Reactome: R-HSA-72649;Reactome: R-HSA-110320;Reactome: R-HSA-202424;Reactome: R-HSA-4608870;Reactome: R-HSA-1253288;Reactome: R-HSA-450321;Reactome: R-HSA-936964;Reactome: R-HSA-937039;Reactome: R-HSA-349425;Reactome: R-HSA-8951664;Reactome: R-HSA-174084	"Stimuli-sensing channels";"Downregulation of TGF-beta receptor signaling";"Senescence-Associated Secretory Phenotype (SASP)";"Negative regulation of FGFR4 signaling";"Prevention of phagosomal-lysosomal fusion";"Regulation of TP53 Activity through Phosphorylation";"Assembly Of The HIV Virion";"Orc1 removal from chromatin";"Circadian Clock";"NIK-->noncanonical NF-kB signaling";"Negative regulation of MET activity";"Hedgehog ligand biogenesis";"Spry regulation of FGF signaling";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Membrane binding and targetting of GAG proteins";"Degradation of GLI1 by the proteasome";"Degradation of GLI2 by the proteasome";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Vpu mediated degradation of CD4";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Dual Incision in GG-NER";"Regulation of TNFR1 signaling";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"APC/C:Cdc20 mediated degradation of Cyclin B";"CDT1 association with the CDC6:ORC:origin complex";"Negative regulation of FGFR3 signaling";"UCH proteinases";"Ovarian tumor domain proteases";"Modulation by Mtb of host immune system";"Downregulation of SMAD2/3:SMAD4 transcriptional activity";"SCF-beta-TrCP mediated degradation of Emi1";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Formation of TC-NER Pre-Incision Complex";"Iron uptake and transport";"Major pathway of rRNA processing in the nucleolus and cytosol";"IKK complex recruitment mediated by RIP1";"Termination of translesion DNA synthesis";"Regulation of RUNX2 expression and activity";"Peroxisomal protein import";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Constitutive Signaling by NOTCH1 HD Domain Mutants";"Dectin-1 mediated noncanonical NF-kB signaling";"E3 ubiquitin ligases ubiquitinate target proteins";"MAP3K8 (TPL2)-dependent MAPK1/3 activation";"Vif-mediated degradation of APOBEC3G";"Negative regulation of MAPK pathway";"Eukaryotic Translation Termination";"Budding and maturation of HIV virion";"Degradation of AXIN";"Ub-specific processing proteases";"Regulation of TP53 Activity through Methylation";"Stabilization of p53";"Degradation of beta-catenin by the destruction complex";"Metalloprotease DUBs";"TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling";"ER Quality Control Compartment (ERQC)";"TICAM1,TRAF6-dependent induction of TAK1 complex";"Activated NOTCH1 Transmits Signal to the Nucleus";"Activation of NF-kappaB in B cells";"Negative regulation of NOTCH4 signaling";"TRAF6-mediated induction of TAK1 complex within TLR4 complex";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Degradation of DVL";"Hedgehog 'on' state";"NF-kB is activated and signals survival";"TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)";"PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Formation of a pool of free 40S subunits";"p75NTR recruits signalling complexes";"IRAK2 mediated activation of TAK1 complex";"Formation of the ternary complex, and subsequently, the 43S complex";"Interleukin-1 signaling";"ISG15 antiviral mechanism";"Regulation of PTEN localization";"Oncogene Induced Senescence";"Negative regulators of DDX58/IFIH1 signaling";"DNA Damage Recognition in GG-NER";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"L13a-mediated translational silencing of Ceruloplasmin expression";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Recognition of DNA damage by PCNA-containing replication complex";"Peptide chain elongation";"TNFR1-induced NFkappaB signaling pathway";"Dual incision in TC-NER";"Ubiquitin-dependent degradation of Cyclin D";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Josephin domain DUBs";"Cargo recognition for clathrin-mediated endocytosis";"Late endosomal microautophagy";"InlB-mediated entry of Listeria monocytogenes into host cell";"Oxidative Stress Induced Senescence";"FCERI mediated NF-kB activation";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"TICAM1-dependent activation of IRF3/IRF7";"Ribosomal scanning and start codon recognition";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"CDK-mediated phosphorylation and removal of Cdc6";"Chaperone Mediated Autophagy";"Regulation of FZD by ubiquitination";"Regulation of RUNX3 expression and activity";"Translesion synthesis by POLI";"N-glycan trimming in the ER and Calnexin/Calreticulin cycle";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Synthesis of active ubiquitin: roles of E1 and E2 enzymes";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Regulation of PLK1 Activity at G2/M Transition";"Regulation of signaling by CBL";"SCF(Skp2)-mediated degradation of p27/p21";"CLEC7A (Dectin-1) signaling";"TAK1 activates NFkB by phosphorylation and activation of IKKs complex";"NOD1/2 Signaling Pathway";"Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants";"Regulation of necroptotic cell death";"SRP-dependent cotranslational protein targeting to membrane";"TCF dependent signaling in response to WNT";"Separation of Sister Chromatids";"Pink/Parkin Mediated Mitophagy";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Formation of Incision Complex in GG-NER";"IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation";"Regulation of RAS by GAPs";"APC-Cdc20 mediated degradation of Nek2A";"InlA-mediated entry of Listeria monocytogenes into host cells";"Translesion synthesis by REV1";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Downregulation of ERBB2:ERBB3 signaling";"DDX58/IFIH1-mediated induction of interferon-alpha/beta";"Viral mRNA Translation";"HDR through Homologous Recombination (HRR)";"Processing of DNA double-strand break ends";"ABC-family proteins mediated transport";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Negative regulation of FGFR2 signaling";"Negative regulation of FGFR1 signaling";"Regulation of expression of SLITs and ROBOs";"TNFR2 non-canonical NF-kB pathway";"Selenocysteine synthesis";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"ER-Phagosome pathway";"EGFR downregulation";"G2/M Checkpoints";"Amyloid fiber formation";"Regulation of PTEN stability and activity";"Downregulation of ERBB2 signaling";"Regulation of innate immune responses to cytosolic DNA";"MAPK6/MAPK4 signaling";"NOTCH1 Intracellular Domain Regulates Transcription";"Alpha-protein kinase 1 signaling pathway";"NRIF signals cell death from the nucleus";"Regulation of TP53 Degradation";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Endosomal Sorting Complex Required For Transport (ESCRT)";"APC/C:Cdc20 mediated degradation of Securin";"Translesion synthesis by POLK";"TICAM1, RIP1-mediated IKK complex recruitment";"Antigen processing: Ubiquitination & Proteasome degradation";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Cyclin D associated events in G1";"Aggrephagy";"activated TAK1 mediates p38 MAPK activation";"Myoclonic epilepsy of Lafora";"Fanconi Anemia Pathway";"Clathrin-mediated endocytosis";"GLI3 is processed to GLI3R by the proteasome";"Deactivation of the beta-catenin transactivating complex";"Defective CFTR causes cystic fibrosis";"Glycogen synthesis";"Translation initiation complex formation";"Translesion Synthesis by POLH";"Downstream TCR signaling";"Asymmetric localization of PCP proteins";"Downregulation of ERBB4 signaling";"JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1";"Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon";"IRAK1 recruits IKK complex";"Autodegradation of the E3 ubiquitin ligase COP1";"Neddylation";"Autodegradation of Cdh1 by Cdh1:APC/C"
XP_046422997.1	1	Reactome: R-HSA-204005	"COPII-mediated vesicle transport"
XP_046413208.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046427166.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046420812.1	5	Reactome: R-HSA-9633012;Reactome: R-HSA-8963693;KEGG: 00250+6.3.5.4;Reactome: R-HSA-9648895;Reactome: R-HSA-380994	"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Aspartate and asparagine metabolism";"Alanine, aspartate and glutamate metabolism";"Response of EIF2AK1 (HRI) to heme deficiency";"ATF4 activates genes in response to endoplasmic reticulum stress"
XP_046428778.1	7	KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1	"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Human cytomegalovirus infection";"Thermogenesis";"Relaxin signaling pathway";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection"
XP_046433230.1	3	KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16	"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
XP_046419784.1	1	Reactome: R-HSA-390522	"Striated Muscle Contraction"
XP_046427797.1	1	Reactome: R-HSA-196819	"Vitamin B1 (thiamin) metabolism"
XP_046418626.1	1	Reactome: R-HSA-162791	"Attachment of GPI anchor to uPAR"
XP_046433269.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046436194.1	1	Reactome: R-HSA-418594	"G alpha (i) signalling events"
XP_046431340.1	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
XP_046435712.1	2	KEGG: 00970+6.3.5.7;Reactome: R-HSA-2142753	"Aminoacyl-tRNA biosynthesis";"Arachidonic acid metabolism"
XP_046412148.1	1	Reactome: R-HSA-9616222	"Transcriptional regulation of granulopoiesis"
XP_046435474.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_046430475.1	4	Reactome: R-HSA-2122947;Reactome: R-HSA-201722;Reactome: R-HSA-4641265;Reactome: R-HSA-3769402	"NOTCH1 Intracellular Domain Regulates Transcription";"Formation of the beta-catenin:TCF transactivating complex";"Repression of WNT target genes";"Deactivation of the beta-catenin transactivating complex"
XP_046417869.1	1	Reactome: R-HSA-196741	"Cobalamin (Cbl, vitamin B12) transport and metabolism"
XP_046431656.1	1	Reactome: R-HSA-435368	"Zinc efflux and compartmentalization by the SLC30 family"
XP_046425724.1	13	Reactome: R-HSA-1632852;Reactome: R-HSA-166208;Reactome: R-HSA-5218920;Reactome: R-HSA-165159;Reactome: R-HSA-380972;Reactome: R-HSA-5674400;Reactome: R-HSA-6804757;Reactome: R-HSA-1257604;Reactome: R-HSA-3371571;Reactome: R-HSA-389357;Reactome: R-HSA-5628897;Reactome: R-HSA-9639288;Reactome: R-HSA-8943724	"Macroautophagy";"mTORC1-mediated signalling";"VEGFR2 mediated vascular permeability";"mTOR signalling";"Energy dependent regulation of mTOR by LKB1-AMPK";"Constitutive Signaling by AKT1 E17K in Cancer";"Regulation of TP53 Degradation";"PIP3 activates AKT signaling";"HSF1-dependent transactivation";"CD28 dependent PI3K/Akt signaling";"TP53 Regulates Metabolic Genes";"Amino acids regulate mTORC1";"Regulation of PTEN gene transcription"
XP_046420062.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046436418.1	7	Reactome: R-HSA-76061;Reactome: R-HSA-76066;Reactome: R-HSA-76071;Reactome: R-HSA-749476;Reactome: R-HSA-1834949;Reactome: R-HSA-73980;Reactome: R-HSA-73780	"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Abortive And Retractive Initiation";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Transcription Termination";"RNA Polymerase III Chain Elongation"
XP_046434862.1	1	Reactome: R-HSA-203615	"eNOS activation"
XP_046431125.1	2	Reactome: R-HSA-445355;Reactome: R-HSA-390522	"Smooth Muscle Contraction";"Striated Muscle Contraction"
XP_046432223.1	42	KEGG: 00310+4.2.1.17+1.1.1.35;MetaCyc: PWY-7778;MetaCyc: PWY-5138;KEGG: 00623+1.1.1.35;KEGG: 00720+4.2.1.17+1.1.1.35;KEGG: 00410+4.2.1.17;MetaCyc: PWY-5177;MetaCyc: PWY-7654;KEGG: 00930+4.2.1.17+1.1.1.35;MetaCyc: PWY-5789;KEGG: 00627+4.2.1.17;MetaCyc: PWY-7216;KEGG: 00071+4.2.1.17+1.1.1.35;MetaCyc: PWY-5109;MetaCyc: PWY-7094;KEGG: 00360+4.2.1.17;MetaCyc: PWY-6944;KEGG: 00650+5.1.2.3+4.2.1.17+1.1.1.35;KEGG: 00592+4.2.1.17;MetaCyc: PWY-1361;KEGG: 00380+4.2.1.17+1.1.1.35;MetaCyc: PWY-6863;MetaCyc: PWY-5136;KEGG: 00062+4.2.1.17+1.1.1.35;KEGG: 00650+4.2.1.17+1.1.1.35;KEGG: 00903+4.2.1.17;KEGG: 00362+4.2.1.17+1.1.1.35;MetaCyc: PWY-7007;MetaCyc: PWY-7606;MetaCyc: PWY-6946;MetaCyc: PWY-6883;MetaCyc: PWY-6945;MetaCyc: PWY-7726;MetaCyc: PWY-6435;KEGG: 00640+4.2.1.17;KEGG: 00071+5.1.2.3+4.2.1.17+1.1.1.35;MetaCyc: PWY-7656;MetaCyc: PWY-7401;MetaCyc: PWY-6583;KEGG: 00281+4.2.1.17+1.1.1.35;MetaCyc: PWY-7779;KEGG: 00280+4.2.1.17+1.1.1.35	"Lysine degradation";"2-methylpropene degradation";"Fatty acid beta-oxidation IV (unsaturated, even number)";"Toluene degradation";"Carbon fixation pathways in prokaryotes";"beta-Alanine metabolism";"Glutaryl-coa degradation";"(8E,10E)-dodeca-8,10-dienol biosynthesis";"Caprolactam degradation";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Aminobenzoate degradation";"(R)- and (S)-3-hydroxybutanoate biosynthesis (engineered)";"Fatty acid degradation";"Fermentation to 2-methylbutanoate";"Fatty acid salvage";"Phenylalanine metabolism";"Androstenedione degradation";"Butanoate metabolism";"alpha-Linolenic acid metabolism";"Benzoyl-coa degradation I (aerobic)";"Tryptophan metabolism";"Pyruvate fermentation to hexanol (engineered)";"Fatty acid beta-oxidation II (plant peroxisome)";"Fatty acid elongation";"Butanoate metabolism";"Limonene and pinene degradation";"Benzoate degradation";"Methyl ketone biosynthesis (engineered)";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Cholesterol degradation to androstenedione II (cholesterol dehydrogenase)";"Pyruvate fermentation to butanol II (engineered)";"Cholesterol degradation to androstenedione I (cholesterol oxidase)";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"4-hydroxybenzoate biosynthesis III (plants)";"Propanoate metabolism";"Fatty acid degradation";"Spodoptera littoralis pheromone biosynthesis";"Crotonate fermentation (to acetate and cyclohexane carboxylate)";"Pyruvate fermentation to butanol I";"Geraniol degradation";"Methyl tert-butyl ether degradation";"Valine, leucine and isoleucine degradation"
XP_046415383.1	1	Reactome: R-HSA-111957	"Cam-PDE 1 activation"
XP_046420991.1	1	Reactome: R-HSA-1655829	"Regulation of cholesterol biosynthesis by SREBP (SREBF)"
XP_046429916.1	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
XP_046428884.1	20	MetaCyc: PWY-7858;MetaCyc: PWY-7291;MetaCyc: PWY-6920;KEGG: 00071+1.3.3.6;MetaCyc: PWY-7338;MetaCyc: PWY-735;KEGG: 00640+1.3.3.6;KEGG: 00592+1.3.3.6;MetaCyc: PWY-6837;KEGG: 00410+1.3.3.6;Reactome: R-HSA-9033241;MetaCyc: PWY-5136;MetaCyc: PWY-7854;MetaCyc: PWY-7007;MetaCyc: PWY-7606;MetaCyc: PWY-7726;MetaCyc: PWY-7288;MetaCyc: PWY-7340;MetaCyc: PWY-7574;MetaCyc: PWY-7337	"(5Z)-dodecenoate biosynthesis II";"Oleate beta-oxidation (isomerase-dependent, yeast)";"6-gingerol analog biosynthesis (engineered)";"Fatty acid degradation";"10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast)";"Jasmonic acid biosynthesis";"Propanoate metabolism";"alpha-Linolenic acid metabolism";"Fatty acid beta-oxidation V (unsaturated, odd number, di-isomerase-dependent)";"beta-Alanine metabolism";"Peroxisomal protein import";"Fatty acid beta-oxidation II (plant peroxisome)";"Crotonyl-coa/ethylmalonyl-coa/hydroxybutyryl-coa cycle (engineered)";"Methyl ketone biosynthesis (engineered)";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"Fatty acid beta-oxidation VII (yeast peroxisome)";"9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast)";"Propanoyl-coa degradation II";"10-cis-heptadecenoyl-CoA degradation (yeast)"
XP_046425092.1	7	Reactome: R-HSA-1362300;Reactome: R-HSA-2173796;Reactome: R-HSA-1538133;Reactome: R-HSA-69231;Reactome: R-HSA-6804114;Reactome: R-HSA-1362277;Reactome: R-HSA-69205	"Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"G0 and Early G1";"Cyclin D associated events in G1";"TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest";"Transcription of E2F targets under negative control by DREAM complex";"G1/S-Specific Transcription"
XP_046411924.1	13	Reactome: R-HSA-499943;MetaCyc: PWY-7210;MetaCyc: PWY-7184;MetaCyc: PWY-7222;MetaCyc: PWY-6545;KEGG: 00240+1.17.4.1;MetaCyc: PWY-7220;KEGG: 00983+1.17.4.1;KEGG: 00230+1.17.4.1;KEGG: 00480+1.17.4.1;MetaCyc: PWY-7226;MetaCyc: PWY-7227;MetaCyc: PWY-7198	"Interconversion of nucleotide di- and triphosphates";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Guanosine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Pyrimidine metabolism";"Adenosine deoxyribonucleotides de novo biosynthesis II";"Drug metabolism - other enzymes";"Purine metabolism";"Glutathione metabolism";"Guanosine deoxyribonucleotides de novo biosynthesis I";"Adenosine deoxyribonucleotides de novo biosynthesis";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV"
XP_046433177.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046436025.1	1	Reactome: R-HSA-5662702	"Melanin biosynthesis"
XP_046415771.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_046415240.1	2	KEGG: 00230+2.7.4.8;MetaCyc: PWY-7221	"Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis"
XP_046433781.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
XP_046413616.1	1	Reactome: R-HSA-6809371	"Formation of the cornified envelope"
XP_046418346.1	1	Reactome: R-HSA-9022692	"Regulation of MECP2 expression and activity"
XP_046429183.1	18	KEGG: 00564+3.1.1.4;KEGG: 00591+3.1.1.4;MetaCyc: PWY-8053;Reactome: R-HSA-1482839;MetaCyc: PWY-7416;MetaCyc: PWY-7409;MetaCyc: PWY-7783;MetaCyc: PWY-6803;Reactome: R-HSA-1482925;Reactome: R-HSA-1482801;MetaCyc: PWY-7417;KEGG: 00592+3.1.1.4;Reactome: R-HSA-1483166;KEGG: 00590+3.1.1.4;KEGG: 00565+3.1.1.4;Reactome: R-HSA-1482788;MetaCyc: PWY-8051;Reactome: R-HSA-1482922	"Glycerophospholipid metabolism";"Linoleic acid metabolism";"Anandamide biosynthesis II";"Acyl chain remodelling of PE";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Plasmalogen degradation";"Phosphatidylcholine acyl editing";"Acyl chain remodelling of PG";"Acyl chain remodelling of PS";"Phospholipid remodeling (phosphatidate, yeast)";"alpha-Linolenic acid metabolism";"Synthesis of PA";"Arachidonic acid metabolism";"Ether lipid metabolism";"Acyl chain remodelling of PC";"Anandamide biosynthesis I";"Acyl chain remodelling of PI"
XP_046409419.1	2	Reactome: R-HSA-375276;Reactome: R-HSA-416476	"Peptide ligand-binding receptors";"G alpha (q) signalling events"
XP_046432440.1	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
XP_046414621.1	7	MetaCyc: PWY-7158;MetaCyc: PWY-6134;KEGG: 00400+1.14.16.1;Reactome: R-HSA-2160456;KEGG: 00790+1.14.16.1;Reactome: R-HSA-8964208;KEGG: 00360+1.14.16.1	"L-phenylalanine degradation V";"L-tyrosine biosynthesis IV";"Phenylalanine, tyrosine and tryptophan biosynthesis";"Phenylketonuria";"Folate biosynthesis";"Phenylalanine metabolism";"Phenylalanine metabolism"
XP_046431181.1	2	Reactome: R-HSA-9627069;Reactome: R-HSA-111458	"Regulation of the apoptosome activity";"Formation of apoptosome"
XP_046424059.1	3	Reactome: R-HSA-3065676;Reactome: R-HSA-983168;Reactome: R-HSA-3065678	"SUMO is conjugated to E1 (UBA2:SAE1)";"Antigen processing: Ubiquitination & Proteasome degradation";"SUMO is transferred from E1 to E2 (UBE2I, UBC9)"
XP_046414184.1	1	Reactome: R-HSA-1660662	"Glycosphingolipid metabolism"
XP_046414337.1	2	Reactome: R-HSA-6814122;Reactome: R-HSA-418594	"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"G alpha (i) signalling events"
XP_046421653.1	2	Reactome: R-HSA-373752;Reactome: R-HSA-525793	"Netrin-1 signaling";"Myogenesis"
XP_046410312.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_046426752.1	1	Reactome: R-HSA-110320	"Translesion Synthesis by POLH"
XP_046413283.1	16	Reactome: R-HSA-8943723;Reactome: R-HSA-1912408;Reactome: R-HSA-8986944;Reactome: R-HSA-2559585;Reactome: R-HSA-5628897;Reactome: R-HSA-8948700;Reactome: R-HSA-9018519;Reactome: R-HSA-8936459;Reactome: R-HSA-426496;Reactome: R-HSA-9029569;Reactome: R-HSA-2559580;Reactome: R-HSA-9022692;Reactome: R-HSA-8853884;Reactome: R-HSA-5687128;Reactome: R-HSA-4086398;Reactome: R-HSA-8934593	"Regulation of PTEN mRNA translation";"Pre-NOTCH Transcription and Translation";"Transcriptional Regulation by MECP2";"Oncogene Induced Senescence";"TP53 Regulates Metabolic Genes";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"Estrogen-dependent gene expression";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Post-transcriptional silencing by small RNAs";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Oxidative Stress Induced Senescence";"Regulation of MECP2 expression and activity";"Transcriptional Regulation by VENTX";"MAPK6/MAPK4 signaling";"Ca2+ pathway";"Regulation of RUNX1 Expression and Activity"
XP_046410421.1	3	Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-212436	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"Generic Transcription Pathway"
XP_046421693.1	3	Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-212436	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"Generic Transcription Pathway"
XP_046430944.1	1	Reactome: R-HSA-8854691	"Interleukin-20 family signaling"
XP_046436227.1	3	Reactome: R-HSA-5620916;Reactome: R-HSA-264876;Reactome: R-HSA-1445148	"VxPx cargo-targeting to cilium";"Insulin processing";"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
XP_046428856.1	4	MetaCyc: PWY-8051;KEGG: 00592+3.1.1.32;MetaCyc: PWY-6803;KEGG: 00564+3.1.1.32	"Anandamide biosynthesis I";"alpha-Linolenic acid metabolism";"Phosphatidylcholine acyl editing";"Glycerophospholipid metabolism"
XP_046431393.1	9	KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04714+2.7.11.1;Reactome: R-HSA-5674400;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;Reactome: R-HSA-198323	"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Thermogenesis";"Constitutive Signaling by AKT1 E17K in Cancer";"Relaxin signaling pathway";"Human cytomegalovirus infection";"PI3K-Akt signaling pathway";"mTOR signaling pathway";"AKT phosphorylates targets in the cytosol"
XP_046412991.1	1	Reactome: R-HSA-6811434	"COPI-dependent Golgi-to-ER retrograde traffic"
XP_046429651.1	5	Reactome: R-HSA-975578;MetaCyc: PWY-7426;KEGG: 00513+2.4.1.68;KEGG: 00533+2.4.1.68;KEGG: 00510+2.4.1.68	"Reactions specific to the complex N-glycan synthesis pathway";"Complex N-linked glycan biosynthesis (vertebrates)";"Various types of N-glycan biosynthesis";"Glycosaminoglycan biosynthesis - keratan sulfate";"N-Glycan biosynthesis"
XP_046427631.1	1	Reactome: R-HSA-426486	"Small interfering RNA (siRNA) biogenesis"
XP_046424497.1	5	Reactome: R-HSA-6807878;Reactome: R-HSA-6811440;Reactome: R-HSA-6811438;Reactome: R-HSA-204005;Reactome: R-HSA-6811434	"COPI-mediated anterograde transport";"Retrograde transport at the Trans-Golgi-Network";"Intra-Golgi traffic";"COPII-mediated vesicle transport";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_046418126.1	1	Reactome: R-HSA-5610787	"Hedgehog 'off' state"
XP_046424221.1	5	Reactome: R-HSA-197264;MetaCyc: PWY-5381;Reactome: R-HSA-6798695;Reactome: R-HSA-1368108;KEGG: 00760+6.3.4.21	"Nicotinamide salvaging";"Pyridine nucleotide cycling (plants)";"Neutrophil degranulation";"BMAL1:CLOCK,NPAS2 activates circadian gene expression";"Nicotinate and nicotinamide metabolism"
XP_046425363.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_046420775.1	2	KEGG: 00770+2.7.1.24;MetaCyc: PWY-7851	"Pantothenate and CoA biosynthesis";"Coenzyme A biosynthesis II (eukaryotic)"
XP_046435514.1	14	Reactome: R-HSA-113418;Reactome: R-HSA-112382;Reactome: R-HSA-167238;Reactome: R-HSA-167243;Reactome: R-HSA-167246;Reactome: R-HSA-75955;Reactome: R-HSA-167290;Reactome: R-HSA-167152;Reactome: R-HSA-674695;Reactome: R-HSA-167158;Reactome: R-HSA-167242;Reactome: R-HSA-167287;Reactome: R-HSA-167200;Reactome: R-HSA-6796648	"Formation of the Early Elongation Complex";"Formation of RNA Pol II elongation complex";"Pausing and recovery of Tat-mediated HIV elongation";"Tat-mediated HIV elongation arrest and recovery";"Tat-mediated elongation of the HIV-1 transcript";"RNA Polymerase II Transcription Elongation";"Pausing and recovery of HIV elongation";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Polymerase II Pre-transcription Events";"Formation of the HIV-1 Early Elongation Complex";"Abortive elongation of HIV-1 transcript in the absence of Tat";"HIV elongation arrest and recovery";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"TP53 Regulates Transcription of DNA Repair Genes"
XP_046433015.1	7	Reactome: R-HSA-1362277;Reactome: R-HSA-69205;Reactome: R-HSA-69656;Reactome: R-HSA-69202;Reactome: R-HSA-1538133;Reactome: R-HSA-1362300;Reactome: R-HSA-156711	"Transcription of E2F targets under negative control by DREAM complex";"G1/S-Specific Transcription";"Cyclin A:Cdk2-associated events at S phase entry";"Cyclin E associated events during G1/S transition";"G0 and Early G1";"Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1";"Polo-like kinase mediated events"
XP_046421755.1	56	Reactome: R-HSA-1234176;Reactome: R-HSA-8948751;Reactome: R-HSA-69481;Reactome: R-HSA-8852276;Reactome: R-HSA-5610783;Reactome: R-HSA-5689603;Reactome: R-HSA-68827;Reactome: R-HSA-5607764;Reactome: R-HSA-187577;Reactome: R-HSA-180534;Reactome: R-HSA-174113;Reactome: R-HSA-5687128;Reactome: R-HSA-9020702;Reactome: R-HSA-8854050;Reactome: R-HSA-68949;Reactome: R-HSA-1169091;Reactome: R-HSA-382556;Reactome: R-HSA-2871837;Reactome: R-HSA-174178;Reactome: R-HSA-195253;Reactome: R-HSA-69017;Reactome: R-HSA-5358346;Reactome: R-HSA-69601;Reactome: R-HSA-5676590;Reactome: R-HSA-5362768;Reactome: R-HSA-9604323;Reactome: R-HSA-5668541;Reactome: R-HSA-350562;Reactome: R-HSA-8941858;Reactome: R-HSA-9010553;Reactome: R-HSA-1236974;Reactome: R-HSA-5610780;Reactome: R-HSA-450408;Reactome: R-HSA-5632684;Reactome: R-HSA-211733;Reactome: R-HSA-4641258;Reactome: R-HSA-8939236;Reactome: R-HSA-180585;Reactome: R-HSA-5678895;Reactome: R-HSA-5610785;Reactome: R-HSA-1236978;Reactome: R-HSA-4641257;Reactome: R-HSA-4608870;Reactome: R-HSA-202424;Reactome: R-HSA-75815;Reactome: R-HSA-174084;Reactome: R-HSA-8951664;Reactome: R-HSA-5689880;Reactome: R-HSA-349425;Reactome: R-HSA-2467813;Reactome: R-HSA-174154;Reactome: R-HSA-174184;Reactome: R-HSA-8939902;Reactome: R-HSA-5607761;Reactome: R-HSA-983168;Reactome: R-HSA-5658442	"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of PTEN stability and activity";"G2/M Checkpoints";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Degradation of GLI2 by the proteasome";"UCH proteinases";"CDT1 association with the CDC6:ORC:origin complex";"CLEC7A (Dectin-1) signaling";"SCF(Skp2)-mediated degradation of p27/p21";"Vpu mediated degradation of CD4";"SCF-beta-TrCP mediated degradation of Emi1";"MAPK6/MAPK4 signaling";"Interleukin-1 signaling";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Orc1 removal from chromatin";"Activation of NF-kappaB in B cells";"ABC-family proteins mediated transport";"FCERI mediated NF-kB activation";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Degradation of beta-catenin by the destruction complex";"CDK-mediated phosphorylation and removal of Cdc6";"Hedgehog ligand biogenesis";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"NIK-->noncanonical NF-kB signaling";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Negative regulation of NOTCH4 signaling";"TNFR2 non-canonical NF-kB pathway";"Regulation of ornithine decarboxylase (ODC)";"Regulation of RUNX3 expression and activity";"Regulation of expression of SLITs and ROBOs";"ER-Phagosome pathway";"Degradation of GLI1 by the proteasome";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Hedgehog 'on' state";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Degradation of DVL";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Vif-mediated degradation of APOBEC3G";"Defective CFTR causes cystic fibrosis";"GLI3 is processed to GLI3R by the proteasome";"Cross-presentation of soluble exogenous antigens (endosomes)";"Degradation of AXIN";"Asymmetric localization of PCP proteins";"Downstream TCR signaling";"Ubiquitin-dependent degradation of Cyclin D";"Autodegradation of Cdh1 by Cdh1:APC/C";"Neddylation";"Ub-specific processing proteases";"Autodegradation of the E3 ubiquitin ligase COP1";"Separation of Sister Chromatids";"APC/C:Cdc20 mediated degradation of Securin";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Regulation of RUNX2 expression and activity";"Dectin-1 mediated noncanonical NF-kB signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Regulation of RAS by GAPs"
XP_046426476.1	1	Reactome: R-HSA-3299685	"Detoxification of Reactive Oxygen Species"
XP_046436687.1	12	Reactome: R-HSA-9648025;Reactome: R-HSA-141444;Reactome: R-HSA-68877;Reactome: R-HSA-9609690;Reactome: R-HSA-2467813;Reactome: R-HSA-6811436;Reactome: R-HSA-9646399;Reactome: R-HSA-2132295;Reactome: R-HSA-3371497;Reactome: R-HSA-6807878;Reactome: R-HSA-5663220;Reactome: R-HSA-2500257	"EML4 and NUDC in mitotic spindle formation";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Mitotic Prometaphase";"HCMV Early Events";"Separation of Sister Chromatids";"COPI-independent Golgi-to-ER retrograde traffic";"Aggrephagy";"MHC class II antigen presentation";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-mediated anterograde transport";"RHO GTPases Activate Formins";"Resolution of Sister Chromatid Cohesion"
XP_046422893.1	1	Reactome: R-HSA-427652	"Sodium-coupled phosphate cotransporters"
XP_046419487.1	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046417961.1	1	Reactome: R-HSA-428890	"Role of ABL in ROBO-SLIT signaling"
XP_046422141.1	6	MetaCyc: PWY-622;MetaCyc: PWY-7900;MetaCyc: PWY-5067;KEGG: 00500+3.2.1.1;KEGG: 00500+2.4.1.18;Reactome: R-HSA-189085	"Starch biosynthesis";"Glycogen biosynthesis III (from alpha-maltose 1-phosphate)";"Glycogen biosynthesis II (from UDP-D-Glucose)";"Starch and sucrose metabolism";"Starch and sucrose metabolism";"Digestion of dietary carbohydrate"
XP_046413332.1	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
XP_046420212.1	6	MetaCyc: PWY-7782;MetaCyc: PWY-5884;MetaCyc: PWY-7656;KEGG: 00073+1.2.1.84;MetaCyc: PWY-6733;Reactome: R-HSA-9640463	"Plasmalogen biosynthesis";"Wax esters biosynthesis I";"Spodoptera littoralis pheromone biosynthesis";"Cutin, suberine and wax biosynthesis";"Sporopollenin precursors biosynthesis";"Wax biosynthesis"
XP_046410967.1	1	Reactome: R-HSA-5576886	"Phase 4 - resting membrane potential"
XP_046435252.1	1	Reactome: R-HSA-1474228	"Degradation of the extracellular matrix"
XP_046434113.1	1	Reactome: R-HSA-2129379	"Molecules associated with elastic fibres"
XP_046424691.1	3	Reactome: R-HSA-6807505;Reactome: R-HSA-76071;Reactome: R-HSA-749476	"RNA polymerase II transcribes snRNA genes";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Abortive And Retractive Initiation"
XP_046435559.1	6	Reactome: R-HSA-5358606;Reactome: R-HSA-5632927;Reactome: R-HSA-5632968;Reactome: R-HSA-5358565;Reactome: R-HSA-6796648;Reactome: R-HSA-5632928	"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"Defective Mismatch Repair Associated With MSH3";"Defective Mismatch Repair Associated With MSH6";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"TP53 Regulates Transcription of DNA Repair Genes";"Defective Mismatch Repair Associated With MSH2"
XP_046431889.1	1	Reactome: R-HSA-212436	"Generic Transcription Pathway"
XP_046424273.1	1	Reactome: R-HSA-156842	"Eukaryotic Translation Elongation"
XP_046412349.1	1	Reactome: R-HSA-71064	"Lysine catabolism"
XP_046425180.1	1	Reactome: R-HSA-4615885	"SUMOylation of DNA replication proteins"
XP_046435310.1	2	Reactome: R-HSA-72165;Reactome: R-HSA-72163	"mRNA Splicing - Minor Pathway";"mRNA Splicing - Major Pathway"
XP_046416795.1	6	Reactome: R-HSA-73863;Reactome: R-HSA-73762;Reactome: R-HSA-73772;Reactome: R-HSA-427359;Reactome: R-HSA-5250924;Reactome: R-HSA-427413	"RNA Polymerase I Transcription Termination";"RNA Polymerase I Transcription Initiation";"RNA Polymerase I Promoter Escape";"SIRT1 negatively regulates rRNA expression";"B-WICH complex positively regulates rRNA expression";"NoRC negatively regulates rRNA expression"
XP_046420433.1	6	MetaCyc: PWY-7900;MetaCyc: PWY-622;MetaCyc: PWY-5067;KEGG: 00500+2.4.1.18;KEGG: 00500+3.2.1.1;Reactome: R-HSA-189085	"Glycogen biosynthesis III (from alpha-maltose 1-phosphate)";"Starch biosynthesis";"Glycogen biosynthesis II (from UDP-D-Glucose)";"Starch and sucrose metabolism";"Starch and sucrose metabolism";"Digestion of dietary carbohydrate"
XP_046423726.1	2	KEGG: 00710+2.7.1.14;Reactome: R-HSA-71336	"Carbon fixation in photosynthetic organisms";"Pentose phosphate pathway"
XP_046421623.1	3	MetaCyc: PWY-6369;Reactome: R-HSA-1855167;KEGG: 04070+2.7.4.24+2.7.4.21	"Inositol diphosphates biosynthesis";"Synthesis of pyrophosphates in the cytosol";"Phosphatidylinositol signaling system"
XP_046426333.1	1	Reactome: R-HSA-5601884	"PIWI-interacting RNA (piRNA) biogenesis"
XP_046428252.1	1	Reactome: R-HSA-5689877	"Josephin domain DUBs"
XP_046433114.1	4	Reactome: R-HSA-674695;Reactome: R-HSA-75955;Reactome: R-HSA-112382;Reactome: R-HSA-8866654	"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Elongation";"Formation of RNA Pol II elongation complex";"E3 ubiquitin ligases ubiquitinate target proteins"
XP_046418369.1	2	Reactome: R-HSA-5693568;Reactome: R-HSA-6783310	"Resolution of D-loop Structures through Holliday Junction Intermediates";"Fanconi Anemia Pathway"
XP_046410650.1	12	MetaCyc: PWY-6672;MetaCyc: PWY-7857;MetaCyc: PWY-5133;KEGG: 00680+6.2.1.1;KEGG: 00620+6.2.1.1;MetaCyc: PWY-5132;KEGG: 00640+6.2.1.1;MetaCyc: PWY-7118;KEGG: 00720+6.2.1.1;KEGG: 00630+6.2.1.1;MetaCyc: PWY-5108;KEGG: 00010+6.2.1.1	"Cis-genanyl-coa degradation";"Adlupulone and adhumulone biosynthesis";"Colupulone and cohumulone biosynthesis";"Methane metabolism";"Pyruvate metabolism";"Lupulone and humulone biosynthesis";"Propanoate metabolism";"Chitin degradation to ethanol";"Carbon fixation pathways in prokaryotes";"Glyoxylate and dicarboxylate metabolism";"L-isoleucine biosynthesis V";"Glycolysis / Gluconeogenesis"
XP_046424037.1	1	Reactome: R-HSA-2022928	"HS-GAG biosynthesis"
XP_046423621.1	5	MetaCyc: PWY-5381;MetaCyc: PWY-7761;Reactome: R-HSA-196807;KEGG: 00760+2.7.7.18;MetaCyc: PWY-5653	"Pyridine nucleotide cycling (plants)";"NAD salvage pathway II (PNC IV cycle)";"Nicotinate metabolism";"Nicotinate and nicotinamide metabolism";"NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde"
XP_046422323.1	2	Reactome: R-HSA-1989781;Reactome: R-HSA-381340	"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation"
XP_046436331.1	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
XP_046428809.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_046431183.1	2	Reactome: R-HSA-390522;Reactome: R-HSA-445355	"Striated Muscle Contraction";"Smooth Muscle Contraction"
XP_046420339.1	1	Reactome: R-HSA-8866654	"E3 ubiquitin ligases ubiquitinate target proteins"
XP_046433352.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046416010.1	8	KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;Reactome: R-HSA-6791226;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1	"Thermogenesis";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Human cytomegalovirus infection";"Relaxin signaling pathway";"Major pathway of rRNA processing in the nucleolus and cytosol";"PI3K-Akt signaling pathway";"mTOR signaling pathway"
XP_046427825.1	1	Reactome: R-HSA-429958	"mRNA decay by 3' to 5' exoribonuclease"
XP_046414923.1	5	Reactome: R-HSA-427413;Reactome: R-HSA-73762;Reactome: R-HSA-73772;Reactome: R-HSA-5250924;Reactome: R-HSA-73863	"NoRC negatively regulates rRNA expression";"RNA Polymerase I Transcription Initiation";"RNA Polymerase I Promoter Escape";"B-WICH complex positively regulates rRNA expression";"RNA Polymerase I Transcription Termination"
XP_046418464.1	2	Reactome: R-HSA-5576892;Reactome: R-HSA-5576893	"Phase 0 - rapid depolarisation";"Phase 2 - plateau phase"
XP_046432987.1	3	Reactome: R-HSA-1989781;Reactome: R-HSA-381340;Reactome: R-HSA-212436	"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation";"Generic Transcription Pathway"
XP_046434489.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046411663.1	2	Reactome: R-HSA-168276;Reactome: R-HSA-1169408	"NS1 Mediated Effects on Host Pathways";"ISG15 antiviral mechanism"
XP_046426290.1	2	Reactome: R-HSA-749476;Reactome: R-HSA-73980	"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Termination"
XP_046409307.1	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046432679.1	3	MetaCyc: PWY-4361;MetaCyc: PWY-7174;KEGG: 00270+5.3.1.23	"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation II";"Cysteine and methionine metabolism"
XP_046426360.1	8	MetaCyc: PWY-6611;KEGG: 00230+3.5.4.4;MetaCyc: PWY-6609;MetaCyc: PWY-7179;Reactome: R-HSA-74217;Reactome: R-HSA-6798695;MetaCyc: PWY-7179-1;Reactome: R-HSA-5683826	"Adenine and adenosine salvage V";"Purine metabolism";"Adenine and adenosine salvage III";"Purine deoxyribonucleosides degradation I";"Purine salvage";"Neutrophil degranulation";"Purine deoxyribonucleosides degradation II";"Surfactant metabolism"
XP_046412502.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_046421005.1	1	Reactome: R-HSA-432047	"Passive transport by Aquaporins"
XP_046430969.1	4	KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16;Reactome: R-HSA-180024	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation";"DARPP-32 events"
XP_046432941.1	1	Reactome: R-HSA-110362	"POLB-Dependent Long Patch Base Excision Repair"
XP_046432539.1	5	KEGG: 00600+3.2.1.22;KEGG: 00052+3.2.1.22;MetaCyc: PWY-6527;KEGG: 00603+3.2.1.22;KEGG: 00561+3.2.1.22	"Sphingolipid metabolism";"Galactose metabolism";"Stachyose degradation";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Glycerolipid metabolism"
XP_046418180.1	4	Reactome: R-HSA-9031525;Reactome: R-HSA-983168;MetaCyc: PWY-7511;Reactome: R-HSA-8866427	"NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake";"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination";"VLDLR internalisation and degradation"
XP_046413231.1	1	Reactome: R-HSA-70221	"Glycogen breakdown (glycogenolysis)"
XP_046412642.1	4	Reactome: R-HSA-350054;Reactome: R-HSA-2644606;Reactome: R-HSA-2894862;Reactome: R-HSA-2122947	"Notch-HLH transcription pathway";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"NOTCH1 Intracellular Domain Regulates Transcription"
XP_046426162.1	2	KEGG: 00561+2.7.1.30;MetaCyc: PWY-4261	"Glycerolipid metabolism";"Glycerol degradation I"
XP_046425944.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_046433468.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_046430619.1	3	Reactome: R-HSA-202427;Reactome: R-HSA-6807004;Reactome: R-HSA-6798695	"Phosphorylation of CD3 and TCR zeta chains";"Negative regulation of MET activity";"Neutrophil degranulation"
XP_046426788.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_046423251.1	1	Reactome: R-HSA-72165	"mRNA Splicing - Minor Pathway"
XP_046426460.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_046431177.1	2	Reactome: R-HSA-6811434;Reactome: R-HSA-6807878	"COPI-dependent Golgi-to-ER retrograde traffic";"COPI-mediated anterograde transport"
XP_046413906.1	3	KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16	"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
XP_046411238.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046411733.1	2	Reactome: R-HSA-432722;Reactome: R-HSA-432720	"Golgi Associated Vesicle Biogenesis";"Lysosome Vesicle Biogenesis"
XP_046428173.1	7	Reactome: R-HSA-446205;KEGG: 00051+5.4.2.8;MetaCyc: PWY-7456;MetaCyc: PWY-5659;KEGG: 00520+5.4.2.8;MetaCyc: PWY-882;MetaCyc: PWY-7586	"Synthesis of GDP-mannose";"Fructose and mannose metabolism";"Beta-(1,4)-mannan degradation";"GDP-mannose biosynthesis";"Amino sugar and nucleotide sugar metabolism";"L-ascorbate biosynthesis I (L-galactose pathway)";"Beta-1,4-d-mannosyl-n-acetyl-d-glucosamine degradation"
XP_046421991.1	2	Reactome: R-HSA-418457;Reactome: R-HSA-1296052	"cGMP effects";"Ca2+ activated K+ channels"
XP_046431519.1	10	Reactome: R-HSA-1855167;Reactome: R-HSA-1855204;KEGG: 00562+2.7.1.134+2.7.1.159;KEGG: 04070+2.7.1.159;MetaCyc: PWY-6554;MetaCyc: PWY-6366;MetaCyc: PWY-6362;MetaCyc: PWY-6365;MetaCyc: PWY-4661;Reactome: R-HSA-983231	"Synthesis of pyrophosphates in the cytosol";"Synthesis of IP3 and IP4 in the cytosol";"Inositol phosphate metabolism";"Phosphatidylinositol signaling system";"1D-myo-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3)";"D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis";"1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)";"D-myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis";"1D-myo-inositol hexakisphosphate biosynthesis III (Spirodela polyrrhiza)";"Factors involved in megakaryocyte development and platelet production"
XP_046418906.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046412536.1	2	Reactome: R-HSA-983231;Reactome: R-HSA-5205685	"Factors involved in megakaryocyte development and platelet production";"Pink/Parkin Mediated Mitophagy"
XP_046412706.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046416991.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046433259.1	13	MetaCyc: PWY-7909;KEGG: 00670+1.5.1.5+3.5.4.9;MetaCyc: PWY-5030;Reactome: R-HSA-196757;KEGG: 00670+6.3.4.3;MetaCyc: PWY-6613;MetaCyc: PWY-2201;KEGG: 00720+1.5.1.5+3.5.4.9;KEGG: 00720+6.3.4.3;MetaCyc: PWY-2161;MetaCyc: PWY-5497;MetaCyc: PWY-1722;MetaCyc: PWY-3841	"Formaldehyde oxidation VII (THF pathway)";"One carbon pool by folate";"L-histidine degradation III";"Metabolism of folate and pterines";"One carbon pool by folate";"Tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate";"Folate transformations I";"Carbon fixation pathways in prokaryotes";"Carbon fixation pathways in prokaryotes";"Folate polyglutamylation";"Purine nucleobases degradation II (anaerobic)";"Formate assimilation into 5,10-methylenetetrahydrofolate";"Folate transformations II (plants)"
XP_046430051.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046429260.1	7	Reactome: R-HSA-8943724;Reactome: R-HSA-9639288;Reactome: R-HSA-5628897;Reactome: R-HSA-165159;Reactome: R-HSA-380972;Reactome: R-HSA-166208;Reactome: R-HSA-1632852	"Regulation of PTEN gene transcription";"Amino acids regulate mTORC1";"TP53 Regulates Metabolic Genes";"mTOR signalling";"Energy dependent regulation of mTOR by LKB1-AMPK";"mTORC1-mediated signalling";"Macroautophagy"
XP_046413397.1	1	Reactome: R-HSA-71288	"Creatine metabolism"
XP_046415187.1	16	Reactome: R-HSA-176408;Reactome: R-HSA-174184;Reactome: R-HSA-176407;Reactome: R-HSA-69017;Reactome: R-HSA-174154;Reactome: R-HSA-2559582;Reactome: R-HSA-174178;Reactome: R-HSA-2467813;Reactome: R-HSA-983168;Reactome: R-HSA-141430;Reactome: R-HSA-174048;Reactome: R-HSA-179409;Reactome: R-HSA-176412;Reactome: R-HSA-174084;Reactome: R-HSA-8853884;Reactome: R-HSA-176409	"Regulation of APC/C activators between G1/S and early anaphase";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"CDK-mediated phosphorylation and removal of Cdc6";"APC/C:Cdc20 mediated degradation of Securin";"Senescence-Associated Secretory Phenotype (SASP)";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Separation of Sister Chromatids";"Antigen processing: Ubiquitination & Proteasome degradation";"Inactivation of APC/C via direct inhibition of the APC/C complex";"APC/C:Cdc20 mediated degradation of Cyclin B";"APC-Cdc20 mediated degradation of Nek2A";"Phosphorylation of the APC/C";"Autodegradation of Cdh1 by Cdh1:APC/C";"Transcriptional Regulation by VENTX";"APC/C:Cdc20 mediated degradation of mitotic proteins"
XP_046428585.1	3	Reactome: R-HSA-194840;Reactome: R-HSA-416482;Reactome: R-HSA-193648	"Rho GTPase cycle";"G alpha (12/13) signalling events";"NRAGE signals death through JNK"
XP_046415099.1	16	Reactome: R-HSA-975957;Reactome: R-HSA-156902;Reactome: R-HSA-72649;Reactome: R-HSA-72764;Reactome: R-HSA-72689;Reactome: R-HSA-192823;Reactome: R-HSA-72695;Reactome: R-HSA-1799339;Reactome: R-HSA-6791226;Reactome: R-HSA-72702;Reactome: R-HSA-975956;Reactome: R-HSA-9633012;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-72706;Reactome: R-HSA-2408557	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Peptide chain elongation";"Translation initiation complex formation";"Eukaryotic Translation Termination";"Formation of a pool of free 40S subunits";"Viral mRNA Translation";"Formation of the ternary complex, and subsequently, the 43S complex";"SRP-dependent cotranslational protein targeting to membrane";"Major pathway of rRNA processing in the nucleolus and cytosol";"Ribosomal scanning and start codon recognition";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Selenocysteine synthesis"
XP_046432384.1	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
XP_046436292.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_046426654.1	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
XP_046425665.1	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
XP_046414360.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046412484.1	4	MetaCyc: PWY-3722;MetaCyc: PWY-7494;KEGG: 00260+1.2.1.8+1.1.99.1;Reactome: R-HSA-6798163	"Glycine betaine biosynthesis II (Gram-positive bacteria)";"Choline degradation IV";"Glycine, serine and threonine metabolism";"Choline catabolism"
XP_046433661.1	2	Reactome: R-HSA-171319;Reactome: R-HSA-201722	"Telomere Extension By Telomerase";"Formation of the beta-catenin:TCF transactivating complex"
XP_046435817.1	1	Reactome: R-HSA-2028269	"Signaling by Hippo"
XP_046434651.1	1	Reactome: R-HSA-209968	"Thyroxine biosynthesis"
XP_046420911.1	2	Reactome: R-HSA-3214841;Reactome: R-HSA-8936459	"PKMTs methylate histone lysines";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"
XP_046421579.1	7	KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1	"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Human cytomegalovirus infection";"Thermogenesis";"Relaxin signaling pathway";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection"
XP_046431132.1	2	Reactome: R-HSA-445355;Reactome: R-HSA-390522	"Smooth Muscle Contraction";"Striated Muscle Contraction"
XP_046409362.1	3	Reactome: R-HSA-73621;Reactome: R-HSA-196807;Reactome: R-HSA-74259	"Pyrimidine catabolism";"Nicotinate metabolism";"Purine catabolism"
XP_046427244.1	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
XP_046431572.1	6	KEGG: 00760+6.3.5.1;KEGG: 00760+6.3.1.5;MetaCyc: PWY-5653;MetaCyc: PWY-7761;MetaCyc: PWY-5381;Reactome: R-HSA-196807	"Nicotinate and nicotinamide metabolism";"Nicotinate and nicotinamide metabolism";"NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde";"NAD salvage pathway II (PNC IV cycle)";"Pyridine nucleotide cycling (plants)";"Nicotinate metabolism"
XP_046421676.1	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
XP_046419570.1	7	Reactome: R-HSA-2979096;Reactome: R-HSA-2691232;MetaCyc: PWY-7511;Reactome: R-HSA-2894862;Reactome: R-HSA-2122948;Reactome: R-HSA-2644606;Reactome: R-HSA-9013507	"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Constitutive Signaling by NOTCH1 HD Domain Mutants";"Protein ubiquitination";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Activated NOTCH1 Transmits Signal to the Nucleus";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH3 Activation and Transmission of Signal to the Nucleus"
XP_046426083.1	7	Reactome: R-HSA-5663220;Reactome: R-HSA-2500257;Reactome: R-HSA-68877;Reactome: R-HSA-2467813;Reactome: R-HSA-9648025;Reactome: R-HSA-606279;Reactome: R-HSA-141444	"RHO GTPases Activate Formins";"Resolution of Sister Chromatid Cohesion";"Mitotic Prometaphase";"Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation";"Deposition of new CENPA-containing nucleosomes at the centromere";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"
XP_046428743.1	2	Reactome: R-HSA-983168;Reactome: R-HSA-8951664	"Antigen processing: Ubiquitination & Proteasome degradation";"Neddylation"
XP_046427713.1	3	Reactome: R-HSA-6784531;MetaCyc: PWY-6689;MetaCyc: PWY-7803	"tRNA processing in the nucleus";"Trna splicing I";"Trna splicing II"
XP_046431432.1	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
XP_046426579.1	2	Reactome: R-HSA-5576894;Reactome: R-HSA-1296072	"Phase 1 - inactivation of fast Na+ channels";"Voltage gated Potassium channels"
XP_046433701.1	2	KEGG: 00970+6.1.1.1;Reactome: R-HSA-379716	"Aminoacyl-tRNA biosynthesis";"Cytosolic tRNA aminoacylation"
XP_046415454.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_046422500.1	1	Reactome: R-HSA-69231	"Cyclin D associated events in G1"
XP_046435035.1	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
XP_046436366.1	4	KEGG: 00633+2.3.1.5;Reactome: R-HSA-156582;KEGG: 00983+2.3.1.5;KEGG: 00232+2.3.1.5	"Nitrotoluene degradation";"Acetylation";"Drug metabolism - other enzymes";"Caffeine metabolism"
XP_046410496.1	2	Reactome: R-HSA-72706;Reactome: R-HSA-72702	"GTP hydrolysis and joining of the 60S ribosomal subunit";"Ribosomal scanning and start codon recognition"
XP_046415553.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046427216.1	5	Reactome: R-HSA-6804758;Reactome: R-HSA-427389;Reactome: R-HSA-73762;Reactome: R-HSA-8943724;Reactome: R-HSA-3214815	"Regulation of TP53 Activity through Acetylation";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"RNA Polymerase I Transcription Initiation";"Regulation of PTEN gene transcription";"HDACs deacetylate histones"
XP_046427197.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046426999.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046431379.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046430596.1	24	Reactome: R-HSA-444257;KEGG: 04151+2.7.11.1;Reactome: R-HSA-114604;KEGG: 04150+2.7.11.1;Reactome: R-HSA-5625740;KEGG: 04926+2.7.11.1;Reactome: R-HSA-2730905;Reactome: R-HSA-389357;Reactome: R-HSA-2871837;KEGG: 05163+2.7.11.1;Reactome: R-HSA-9634635;Reactome: R-HSA-5218921;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;Reactome: R-HSA-5607764;Reactome: R-HSA-354192;Reactome: R-HSA-392451;Reactome: R-HSA-1257604;Reactome: R-HSA-6804757;Reactome: R-HSA-5674400;Reactome: R-HSA-165158;Reactome: R-HSA-5218920;KEGG: 05165+2.7.11.1;Reactome: R-HSA-202424	"RSK activation";"PI3K-Akt signaling pathway";"GPVI-mediated activation cascade";"mTOR signaling pathway";"RHO GTPases activate PKNs";"Relaxin signaling pathway";"Role of LAT2/NTAL/LAB on calcium mobilization";"CD28 dependent PI3K/Akt signaling";"FCERI mediated NF-kB activation";"Human cytomegalovirus infection";"Estrogen-stimulated signaling through PRKCZ";"VEGFR2 mediated cell proliferation";"Human immunodeficiency virus 1 infection";"Thermogenesis";"CLEC7A (Dectin-1) signaling";"Integrin signaling";"G beta:gamma signalling through PI3Kgamma";"PIP3 activates AKT signaling";"Regulation of TP53 Degradation";"Constitutive Signaling by AKT1 E17K in Cancer";"Activation of AKT2";"VEGFR2 mediated vascular permeability";"Human papillomavirus infection";"Downstream TCR signaling"
XP_046417055.1	2	Reactome: R-HSA-983231;Reactome: R-HSA-383280	"Factors involved in megakaryocyte development and platelet production";"Nuclear Receptor transcription pathway"
XP_046431697.1	1	Reactome: R-HSA-1237044	"Erythrocytes take up carbon dioxide and release oxygen"
XP_046431089.1	4	Reactome: R-HSA-8849175;Reactome: R-HSA-5358493;MetaCyc: PWY-7546;MetaCyc: PWY-6482	"Threonine catabolism";"Synthesis of diphthamide-EEF2";"Diphthamide biosynthesis II (eukaryotes)";"Diphthamide biosynthesis I (archaea)"
XP_046414438.1	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
XP_046424596.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046430936.1	2	Reactome: R-HSA-8939243;Reactome: R-HSA-3214858	"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RMTs methylate histone arginines"
XP_046432024.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_046434024.1	4	MetaCyc: PWY-8051;KEGG: 00592+3.1.1.32;MetaCyc: PWY-6803;KEGG: 00564+3.1.1.32	"Anandamide biosynthesis I";"alpha-Linolenic acid metabolism";"Phosphatidylcholine acyl editing";"Glycerophospholipid metabolism"
XP_046422331.1	1	Reactome: R-HSA-5663220	"RHO GTPases Activate Formins"
XP_046434183.1	56	Reactome: R-HSA-382556;Reactome: R-HSA-1169091;Reactome: R-HSA-68949;Reactome: R-HSA-174178;Reactome: R-HSA-2871837;Reactome: R-HSA-195253;Reactome: R-HSA-69017;Reactome: R-HSA-5358346;Reactome: R-HSA-69601;Reactome: R-HSA-9604323;Reactome: R-HSA-5676590;Reactome: R-HSA-5362768;Reactome: R-HSA-5668541;Reactome: R-HSA-350562;Reactome: R-HSA-8941858;Reactome: R-HSA-9010553;Reactome: R-HSA-1236974;Reactome: R-HSA-450408;Reactome: R-HSA-5610780;Reactome: R-HSA-5632684;Reactome: R-HSA-4641258;Reactome: R-HSA-211733;Reactome: R-HSA-1234176;Reactome: R-HSA-8948751;Reactome: R-HSA-69481;Reactome: R-HSA-8852276;Reactome: R-HSA-5610783;Reactome: R-HSA-5689603;Reactome: R-HSA-68827;Reactome: R-HSA-5607764;Reactome: R-HSA-187577;Reactome: R-HSA-180534;Reactome: R-HSA-174113;Reactome: R-HSA-5687128;Reactome: R-HSA-9020702;Reactome: R-HSA-8854050;Reactome: R-HSA-2467813;Reactome: R-HSA-174154;Reactome: R-HSA-174184;Reactome: R-HSA-8939902;Reactome: R-HSA-5607761;Reactome: R-HSA-5658442;Reactome: R-HSA-983168;Reactome: R-HSA-8939236;Reactome: R-HSA-5678895;Reactome: R-HSA-180585;Reactome: R-HSA-5610785;Reactome: R-HSA-1236978;Reactome: R-HSA-4641257;Reactome: R-HSA-4608870;Reactome: R-HSA-75815;Reactome: R-HSA-202424;Reactome: R-HSA-8951664;Reactome: R-HSA-5689880;Reactome: R-HSA-174084;Reactome: R-HSA-349425	"ABC-family proteins mediated transport";"Activation of NF-kappaB in B cells";"Orc1 removal from chromatin";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"FCERI mediated NF-kB activation";"Degradation of beta-catenin by the destruction complex";"CDK-mediated phosphorylation and removal of Cdc6";"Hedgehog ligand biogenesis";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Negative regulation of NOTCH4 signaling";"NIK-->noncanonical NF-kB signaling";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"TNFR2 non-canonical NF-kB pathway";"Regulation of ornithine decarboxylase (ODC)";"Regulation of RUNX3 expression and activity";"Regulation of expression of SLITs and ROBOs";"ER-Phagosome pathway";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Degradation of GLI1 by the proteasome";"Hedgehog 'on' state";"Degradation of DVL";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of PTEN stability and activity";"G2/M Checkpoints";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Degradation of GLI2 by the proteasome";"UCH proteinases";"CDT1 association with the CDC6:ORC:origin complex";"CLEC7A (Dectin-1) signaling";"SCF(Skp2)-mediated degradation of p27/p21";"Vpu mediated degradation of CD4";"SCF-beta-TrCP mediated degradation of Emi1";"MAPK6/MAPK4 signaling";"Interleukin-1 signaling";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Separation of Sister Chromatids";"APC/C:Cdc20 mediated degradation of Securin";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Regulation of RUNX2 expression and activity";"Dectin-1 mediated noncanonical NF-kB signaling";"Regulation of RAS by GAPs";"Antigen processing: Ubiquitination & Proteasome degradation";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Defective CFTR causes cystic fibrosis";"Vif-mediated degradation of APOBEC3G";"GLI3 is processed to GLI3R by the proteasome";"Cross-presentation of soluble exogenous antigens (endosomes)";"Degradation of AXIN";"Asymmetric localization of PCP proteins";"Ubiquitin-dependent degradation of Cyclin D";"Downstream TCR signaling";"Neddylation";"Ub-specific processing proteases";"Autodegradation of Cdh1 by Cdh1:APC/C";"Autodegradation of the E3 ubiquitin ligase COP1"
XP_046430146.1	13	Reactome: R-HSA-72764;Reactome: R-HSA-156902;Reactome: R-HSA-975956;Reactome: R-HSA-6791226;Reactome: R-HSA-975957;Reactome: R-HSA-1799339;Reactome: R-HSA-72706;Reactome: R-HSA-2408557;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-192823;Reactome: R-HSA-72689;Reactome: R-HSA-9633012	"Eukaryotic Translation Termination";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Selenocysteine synthesis";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Viral mRNA Translation";"Formation of a pool of free 40S subunits";"Response of EIF2AK4 (GCN2) to amino acid deficiency"
XP_046428301.1	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
XP_046418938.1	1	Reactome: R-HSA-5693571	"Nonhomologous End-Joining (NHEJ)"
XP_046421182.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046410501.1	2	Reactome: R-HSA-5250971;Reactome: R-HSA-5682910	"Toxicity of botulinum toxin type C (BoNT/C)";"LGI-ADAM interactions"
XP_046411180.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_046419905.1	4	Reactome: R-HSA-917977;Reactome: R-HSA-1222556;Reactome: R-HSA-77387;Reactome: R-HSA-983712	"Transferrin endocytosis and recycling";"ROS and RNS production in phagocytes";"Insulin receptor recycling";"Ion channel transport"
XP_046418623.1	5	Reactome: R-HSA-917729;Reactome: R-HSA-174490;Reactome: R-HSA-9610379;Reactome: R-HSA-162588;Reactome: R-HSA-9615710	"Endosomal Sorting Complex Required For Transport (ESCRT)";"Membrane binding and targetting of GAG proteins";"HCMV Late Events";"Budding and maturation of HIV virion";"Late endosomal microautophagy"
XP_046415608.1	14	MetaCyc: PWY-7587;Reactome: R-HSA-1483166;MetaCyc: PWY-7411;MetaCyc: PWY-5667;MetaCyc: PWY-8051;KEGG: 00564+2.3.1.51;MetaCyc: PWY-6453;KEGG: 00561+2.3.1.51;MetaCyc: PWY-8055;MetaCyc: PWY-7417;MetaCyc: PWY-8053;MetaCyc: PWY-5981;MetaCyc: PWY-7782;MetaCyc: PWY-7589	"Oleate biosynthesis III (cyanobacteria)";"Synthesis of PA";"Phosphatidate biosynthesis (yeast)";"CDP-diacylglycerol biosynthesis I";"Anandamide biosynthesis I";"Glycerophospholipid metabolism";"Stigma estolide biosynthesis";"Glycerolipid metabolism";"Palmitoyl ethanolamide biosynthesis";"Phospholipid remodeling (phosphatidate, yeast)";"Anandamide biosynthesis II";"CDP-diacylglycerol biosynthesis III";"Plasmalogen biosynthesis";"Palmitoleate biosynthesis III (cyanobacteria)"
XP_046430676.1	1	Reactome: R-HSA-189451	"Heme biosynthesis"
XP_046421979.1	2	Reactome: R-HSA-1296052;Reactome: R-HSA-418457	"Ca2+ activated K+ channels";"cGMP effects"
XP_046420646.1	11	Reactome: R-HSA-5685938;Reactome: R-HSA-5693554;Reactome: R-HSA-5693616;Reactome: R-HSA-5358565;Reactome: R-HSA-69473;Reactome: R-HSA-6804756;Reactome: R-HSA-5693579;Reactome: R-HSA-5693607;Reactome: R-HSA-5685942;Reactome: R-HSA-5358606;Reactome: R-HSA-5693568	"HDR through Single Strand Annealing (SSA)";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Presynaptic phase of homologous DNA pairing and strand exchange";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"G2/M DNA damage checkpoint";"Regulation of TP53 Activity through Phosphorylation";"Homologous DNA Pairing and Strand Exchange";"Processing of DNA double-strand break ends";"HDR through Homologous Recombination (HRR)";"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"Resolution of D-loop Structures through Holliday Junction Intermediates"
XP_046421958.1	2	Reactome: R-HSA-1296052;Reactome: R-HSA-418457	"Ca2+ activated K+ channels";"cGMP effects"
XP_046422896.1	1	Reactome: R-HSA-6811438	"Intra-Golgi traffic"
XP_046411088.1	3	Reactome: R-HSA-9018519;Reactome: R-HSA-381340;Reactome: R-HSA-1989781	"Estrogen-dependent gene expression";"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression"
XP_046419265.1	1	Reactome: R-HSA-379716	"Cytosolic tRNA aminoacylation"
XP_046419962.1	19	Reactome: R-HSA-442982;Reactome: R-HSA-9649948;Reactome: R-HSA-6802952;Reactome: R-HSA-3371571;Reactome: R-HSA-6802955;Reactome: R-HSA-5673001;Reactome: R-HSA-9620244;Reactome: R-HSA-5673000;Reactome: R-HSA-6802946;Reactome: R-HSA-9609736;Reactome: R-HSA-936837;Reactome: R-HSA-399719;Reactome: R-HSA-5578775;Reactome: R-HSA-111932;Reactome: R-HSA-9022692;Reactome: R-HSA-438066;Reactome: R-HSA-9617324;Reactome: R-HSA-5576892;Reactome: R-HSA-877300	"Ras activation upon Ca2+ influx through NMDA receptor";"Signaling downstream of RAS mutants";"Signaling by BRAF and RAF fusions";"HSF1-dependent transactivation";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"RAF/MAP kinase cascade";"Long-term potentiation";"RAF activation";"Signaling by moderate kinase activity BRAF mutants";"Assembly and cell surface presentation of NMDA receptors";"Ion transport by P-type ATPases";"Trafficking of AMPA receptors";"Ion homeostasis";"CaMK IV-mediated phosphorylation of CREB";"Regulation of MECP2 expression and activity";"Unblocking of NMDA receptors, glutamate binding and activation";"Negative regulation of NMDA receptor-mediated neuronal transmission";"Phase 0 - rapid depolarisation";"Interferon gamma signaling"
XP_046419665.1	11	KEGG: 00230+4.6.1.1;Reactome: R-HSA-170670;Reactome: R-HSA-163615;Reactome: R-HSA-5610787;Reactome: R-HSA-432040;Reactome: R-HSA-418594;Reactome: R-HSA-418597;Reactome: R-HSA-170660;Reactome: R-HSA-418555;Reactome: R-HSA-163359;Reactome: R-HSA-164378	"Purine metabolism";"Adenylate cyclase inhibitory pathway";"PKA activation";"Hedgehog 'off' state";"Vasopressin regulates renal water homeostasis via Aquaporins";"G alpha (i) signalling events";"G alpha (z) signalling events";"Adenylate cyclase activating pathway";"G alpha (s) signalling events";"Glucagon signaling in metabolic regulation";"PKA activation in glucagon signalling"
XP_046436333.1	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
XP_046429744.1	4	MetaCyc: PWY-6129;KEGG: 00510+2.7.1.108;Reactome: R-HSA-446199;Reactome: R-HSA-4755583	"Dolichol and dolichyl phosphate biosynthesis";"N-Glycan biosynthesis";"Synthesis of Dolichyl-phosphate";"Defective DOLK causes DOLK-CDG (CDG-1m)"
XP_046409669.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_046430603.1	1	Reactome: R-HSA-197264	"Nicotinamide salvaging"
XP_046425433.1	2	Reactome: R-HSA-375280;Reactome: R-HSA-416476	"Amine ligand-binding receptors";"G alpha (q) signalling events"
XP_046410258.1	4	Reactome: R-HSA-6781823;Reactome: R-HSA-8951664;Reactome: R-HSA-5696394;Reactome: R-HSA-8856825	"Formation of TC-NER Pre-Incision Complex";"Neddylation";"DNA Damage Recognition in GG-NER";"Cargo recognition for clathrin-mediated endocytosis"
XP_046433717.1	2	Reactome: R-HSA-8949215;Reactome: R-HSA-8949664	"Mitochondrial calcium ion transport";"Processing of SMDT1"
XP_046422736.1	3	Reactome: R-HSA-8963684;KEGG: 00350+1.13.11.5;KEGG: 00643+1.13.11.5	"Tyrosine catabolism";"Tyrosine metabolism";"Styrene degradation"
XP_046433799.1	6	Reactome: R-HSA-176187;Reactome: R-HSA-68867;Reactome: R-HSA-176974;Reactome: R-HSA-68949;Reactome: R-HSA-68962;Reactome: R-HSA-69052	"Activation of ATR in response to replication stress";"Assembly of the pre-replicative complex";"Unwinding of DNA";"Orc1 removal from chromatin";"Activation of the pre-replicative complex";"Switching of origins to a post-replicative state"
XP_046409981.1	2	Reactome: R-HSA-381038;Reactome: R-HSA-1799339	"XBP1(S) activates chaperone genes";"SRP-dependent cotranslational protein targeting to membrane"
XP_046422407.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046435550.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_046434477.1	4	Reactome: R-HSA-499943;KEGG: 00230+2.7.4.3;MetaCyc: PWY-7219;KEGG: 00730+2.7.4.3	"Interconversion of nucleotide di- and triphosphates";"Purine metabolism";"Adenosine ribonucleotides de novo biosynthesis";"Thiamine metabolism"
XP_046419317.1	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
XP_046420241.1	7	KEGG: 00565+3.1.4.4;Reactome: R-HSA-1483166;KEGG: 00564+3.1.4.4;MetaCyc: PWY-7039;MetaCyc: PWY-3561;Reactome: R-HSA-1483148;Reactome: R-HSA-2029485	"Ether lipid metabolism";"Synthesis of PA";"Glycerophospholipid metabolism";"Phosphatidate metabolism, as a signaling molecule";"Choline biosynthesis III";"Synthesis of PG";"Role of phospholipids in phagocytosis"
XP_046411076.1	13	Reactome: R-HSA-3000157;Reactome: R-HSA-3000178;Reactome: R-HSA-2214320;Reactome: R-HSA-1650814;Reactome: R-HSA-3000171;Reactome: R-HSA-2022090;Reactome: R-HSA-8948216;Reactome: R-HSA-1474244;Reactome: R-HSA-1442490;Reactome: R-HSA-186797;Reactome: R-HSA-2243919;Reactome: R-HSA-419037;Reactome: R-HSA-216083	"Laminin interactions";"ECM proteoglycans";"Anchoring fibril formation";"Collagen biosynthesis and modifying enzymes";"Non-integrin membrane-ECM interactions";"Assembly of collagen fibrils and other multimeric structures";"Collagen chain trimerization";"Extracellular matrix organization";"Collagen degradation";"Signaling by PDGF";"Crosslinking of collagen fibrils";"NCAM1 interactions";"Integrin cell surface interactions"
XP_046431477.1	2	Reactome: R-HSA-3238698;Reactome: R-HSA-373080	"WNT ligand biogenesis and trafficking";"Class B/2 (Secretin family receptors)"
XP_046425519.1	2	Reactome: R-HSA-380320;Reactome: R-HSA-380270	"Recruitment of NuMA to mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes"
XP_046411853.1	5	Reactome: R-HSA-1482883;Reactome: R-HSA-6798695;KEGG: 00561+2.3.1.20;KEGG: 00073+2.3.1.20;Reactome: R-HSA-75109	"Acyl chain remodeling of DAG and TAG";"Neutrophil degranulation";"Glycerolipid metabolism";"Cutin, suberine and wax biosynthesis";"Triglyceride biosynthesis"
XP_046426302.1	2	KEGG: 00450+2.7.9.3;MetaCyc: PWY-6281	"Selenocompound metabolism";"L-selenocysteine biosynthesis II (archaea and eukaryotes)"
XP_046431695.1	1	Reactome: R-HSA-1237044	"Erythrocytes take up carbon dioxide and release oxygen"
XP_046429490.1	5	Reactome: R-HSA-176407;KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16;Reactome: R-HSA-5687128	"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation";"MAPK6/MAPK4 signaling"
XP_046419599.1	7	Reactome: R-HSA-1483213;MetaCyc: PWY-3385;MetaCyc: PWY-7886;KEGG: 00564+2.7.1.32+2.7.1.82;MetaCyc: PWY-7782;MetaCyc: PWY-7818;Reactome: R-HSA-1483191	"Synthesis of PE";"Choline biosynthesis I";"Cell-surface glycoconjugate-linked phosphocholine biosynthesis";"Glycerophospholipid metabolism";"Plasmalogen biosynthesis";"Type IV lipoteichoic acid biosynthesis (S. pneumoniae)";"Synthesis of PC"
XP_046435366.1	2	Reactome: R-HSA-8856825;Reactome: R-HSA-8856828	"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis"
XP_046418086.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046420190.1	3	Reactome: R-HSA-416482;Reactome: R-HSA-194840;Reactome: R-HSA-193648	"G alpha (12/13) signalling events";"Rho GTPase cycle";"NRAGE signals death through JNK"
XP_046411850.1	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
XP_046413163.1	5	Reactome: R-HSA-389661;KEGG: 00020+1.2.4.2;KEGG: 00310+1.2.4.2;MetaCyc: PWY-5084;KEGG: 00380+1.2.4.2	"Glyoxylate metabolism and glycine degradation";"Citrate cycle (TCA cycle)";"Lysine degradation";"2-oxoglutarate decarboxylation to succinyl-CoA";"Tryptophan metabolism"
XP_046418411.1	1	KEGG: 00970+6.1.1.20	"Aminoacyl-tRNA biosynthesis"
XP_046414972.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046431075.1	4	Reactome: R-HSA-3769402;Reactome: R-HSA-201722;Reactome: R-HSA-2122947;Reactome: R-HSA-4641265	"Deactivation of the beta-catenin transactivating complex";"Formation of the beta-catenin:TCF transactivating complex";"NOTCH1 Intracellular Domain Regulates Transcription";"Repression of WNT target genes"
XP_046415876.1	3	Reactome: R-HSA-420029;Reactome: R-HSA-4608870;Reactome: R-HSA-2173791	"Tight junction interactions";"Asymmetric localization of PCP proteins";"TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)"
XP_046422023.1	7	Reactome: R-HSA-5689603;Reactome: R-HSA-5689880;Reactome: R-HSA-3214847;Reactome: R-HSA-606279;Reactome: R-HSA-201722;Reactome: R-HSA-5696394;Reactome: R-HSA-171319	"UCH proteinases";"Ub-specific processing proteases";"HATs acetylate histones";"Deposition of new CENPA-containing nucleosomes at the centromere";"Formation of the beta-catenin:TCF transactivating complex";"DNA Damage Recognition in GG-NER";"Telomere Extension By Telomerase"
XP_046427177.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046410342.1	1	Reactome: R-HSA-5620912	"Anchoring of the basal body to the plasma membrane"
XP_046429046.1	52	Reactome: R-HSA-167242;Reactome: R-HSA-674695;Reactome: R-HSA-6796648;Reactome: R-HSA-77075;Reactome: R-HSA-167200;Reactome: R-HSA-76061;Reactome: R-HSA-167290;Reactome: R-HSA-73772;Reactome: R-HSA-1834949;Reactome: R-HSA-6803529;Reactome: R-HSA-749476;Reactome: R-HSA-167152;Reactome: R-HSA-167172;Reactome: R-HSA-73863;Reactome: R-HSA-5601884;Reactome: R-HSA-76071;Reactome: R-HSA-6782135;Reactome: R-HSA-73779;Reactome: R-HSA-167160;Reactome: R-HSA-5250924;Reactome: R-HSA-75953;Reactome: R-HSA-427413;Reactome: R-HSA-72165;Reactome: R-HSA-167246;Reactome: R-HSA-76066;Reactome: R-HSA-73980;Reactome: R-HSA-167238;Reactome: R-HSA-73776;Reactome: R-HSA-72086;Reactome: R-HSA-168325;Reactome: R-HSA-9018519;Reactome: R-HSA-167161;Reactome: R-HSA-8851708;Reactome: R-HSA-5617472;Reactome: R-HSA-72203;Reactome: R-HSA-76042;Reactome: R-HSA-75955;Reactome: R-HSA-112382;Reactome: R-HSA-73780;Reactome: R-HSA-167243;Reactome: R-HSA-72163;Reactome: R-HSA-167158;Reactome: R-HSA-6781827;Reactome: R-HSA-167287;Reactome: R-HSA-73762;Reactome: R-HSA-5578749;Reactome: R-HSA-167162;Reactome: R-HSA-6807505;Reactome: R-HSA-6781823;Reactome: R-HSA-6782210;Reactome: R-HSA-113418;Reactome: R-HSA-203927	"Abortive elongation of HIV-1 transcript in the absence of Tat";"RNA Polymerase II Pre-transcription Events";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Pol II CTD phosphorylation and interaction with CE";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"Pausing and recovery of HIV elongation";"RNA Polymerase I Promoter Escape";"Cytosolic sensors of pathogen-associated DNA";"FGFR2 alternative splicing";"RNA Polymerase III Abortive And Retractive Initiation";"Formation of HIV elongation complex in the absence of HIV Tat";"Transcription of the HIV genome";"RNA Polymerase I Transcription Termination";"PIWI-interacting RNA (piRNA) biogenesis";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"Dual incision in TC-NER";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"B-WICH complex positively regulates rRNA expression";"RNA Polymerase II Transcription Initiation";"NoRC negatively regulates rRNA expression";"mRNA Splicing - Minor Pathway";"Tat-mediated elongation of the HIV-1 transcript";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Transcription Termination";"Pausing and recovery of Tat-mediated HIV elongation";"RNA Polymerase II Promoter Escape";"mRNA Capping";"Viral Messenger RNA Synthesis";"Estrogen-dependent gene expression";"HIV Transcription Initiation";"Signaling by FGFR2 IIIa TM";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Processing of Capped Intron-Containing Pre-mRNA";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II Transcription Elongation";"Formation of RNA Pol II elongation complex";"RNA Polymerase III Chain Elongation";"Tat-mediated HIV elongation arrest and recovery";"mRNA Splicing - Major Pathway";"Formation of the HIV-1 Early Elongation Complex";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"HIV elongation arrest and recovery";"RNA Polymerase I Transcription Initiation";"Transcriptional regulation by small RNAs";"RNA Polymerase II HIV Promoter Escape";"RNA polymerase II transcribes snRNA genes";"Formation of TC-NER Pre-Incision Complex";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Formation of the Early Elongation Complex";"MicroRNA (miRNA) biogenesis"
XP_046432163.1	1	Reactome: R-HSA-390522	"Striated Muscle Contraction"
XP_046428799.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_046413224.1	1	Reactome: R-HSA-70221	"Glycogen breakdown (glycogenolysis)"
XP_046416082.1	2	Reactome: R-HSA-5628897;Reactome: R-HSA-611105	"TP53 Regulates Metabolic Genes";"Respiratory electron transport"
XP_046421310.1	7	KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1	"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Relaxin signaling pathway";"Thermogenesis";"Human cytomegalovirus infection";"mTOR signaling pathway";"PI3K-Akt signaling pathway"
XP_046426215.1	2	Reactome: R-HSA-6791226;Reactome: R-HSA-390471	"Major pathway of rRNA processing in the nucleolus and cytosol";"Association of TriC/CCT with target proteins during biosynthesis"
XP_046427362.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046418040.1	8	Reactome: R-HSA-68616;Reactome: R-HSA-68689;Reactome: R-HSA-113507;Reactome: R-HSA-68867;Reactome: R-HSA-68962;Reactome: R-HSA-68949;Reactome: R-HSA-68827;Reactome: R-HSA-176187	"Assembly of the ORC complex at the origin of replication";"CDC6 association with the ORC:origin complex";"E2F-enabled inhibition of pre-replication complex formation";"Assembly of the pre-replicative complex";"Activation of the pre-replicative complex";"Orc1 removal from chromatin";"CDT1 association with the CDC6:ORC:origin complex";"Activation of ATR in response to replication stress"
XP_046429141.1	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286	"Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation"
XP_046424061.1	3	MetaCyc: PWY-1801;KEGG: 00680+3.1.2.12;Reactome: R-HSA-156590	"Formaldehyde oxidation II (glutathione-dependent)";"Methane metabolism";"Glutathione conjugation"
XP_046424431.1	1	Reactome: R-HSA-2467813	"Separation of Sister Chromatids"
XP_046421177.1	1	Reactome: R-HSA-3108214	"SUMOylation of DNA damage response and repair proteins"
XP_046422998.1	1	Reactome: R-HSA-216083	"Integrin cell surface interactions"
XP_046418376.1	3	Reactome: R-HSA-193648;Reactome: R-HSA-194840;Reactome: R-HSA-416482	"NRAGE signals death through JNK";"Rho GTPase cycle";"G alpha (12/13) signalling events"
XP_046422465.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_046419511.1	3	Reactome: R-HSA-3000157;Reactome: R-HSA-3000171;Reactome: R-HSA-8874081	"Laminin interactions";"Non-integrin membrane-ECM interactions";"MET activates PTK2 signaling"
XP_046410369.1	15	Reactome: R-HSA-5693568;Reactome: R-HSA-912446;Reactome: R-HSA-5693607;Reactome: R-HSA-5693548;Reactome: R-HSA-5685942;Reactome: R-HSA-5693579;Reactome: R-HSA-2559586;Reactome: R-HSA-5693565;Reactome: R-HSA-69473;Reactome: R-HSA-5693571;Reactome: R-HSA-6804756;Reactome: R-HSA-5693554;Reactome: R-HSA-5693616;Reactome: R-HSA-5685939;Reactome: R-HSA-5685938	"Resolution of D-loop Structures through Holliday Junction Intermediates";"Meiotic recombination";"Processing of DNA double-strand break ends";"Sensing of DNA Double Strand Breaks";"HDR through Homologous Recombination (HRR)";"Homologous DNA Pairing and Strand Exchange";"DNA Damage/Telomere Stress Induced Senescence";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"G2/M DNA damage checkpoint";"Nonhomologous End-Joining (NHEJ)";"Regulation of TP53 Activity through Phosphorylation";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Presynaptic phase of homologous DNA pairing and strand exchange";"HDR through MMEJ (alt-NHEJ)";"HDR through Single Strand Annealing (SSA)"
XP_046435670.1	1	Reactome: R-HSA-611105	"Respiratory electron transport"
XP_046411920.1	1	Reactome: R-HSA-5221030	"TET1,2,3 and TDG demethylate DNA"
XP_046416902.1	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
XP_046425257.1	4	MetaCyc: PWY-6963;KEGG: 00250+1.4.1.14;KEGG: 00910+1.4.1.14;Reactome: R-HSA-73621	"Ammonia assimilation cycle I";"Alanine, aspartate and glutamate metabolism";"Nitrogen metabolism";"Pyrimidine catabolism"
XP_046417219.1	24	Reactome: R-HSA-5617833;Reactome: R-HSA-2132295;Reactome: R-HSA-9609736;Reactome: R-HSA-8955332;Reactome: R-HSA-190861;Reactome: R-HSA-9646399;Reactome: R-HSA-6811436;Reactome: R-HSA-68877;Reactome: R-HSA-8852276;Reactome: R-HSA-190840;Reactome: R-HSA-437239;Reactome: R-HSA-5663220;Reactome: R-HSA-3371497;Reactome: R-HSA-6811434;Reactome: R-HSA-380320;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813;Reactome: R-HSA-9609690;Reactome: R-HSA-9619483;Reactome: R-HSA-2500257;Reactome: R-HSA-983189;Reactome: R-HSA-1445148;Reactome: R-HSA-5626467;Reactome: R-HSA-6807878	"Cilium Assembly";"MHC class II antigen presentation";"Assembly and cell surface presentation of NMDA receptors";"Carboxyterminal post-translational modifications of tubulin";"Gap junction assembly";"Aggrephagy";"COPI-independent Golgi-to-ER retrograde traffic";"Mitotic Prometaphase";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Recycling pathway of L1";"RHO GTPases Activate Formins";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-dependent Golgi-to-ER retrograde traffic";"Recruitment of NuMA to mitotic centrosomes";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids";"HCMV Early Events";"Activation of AMPK downstream of NMDARs";"Resolution of Sister Chromatid Cohesion";"Kinesins";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"RHO GTPases activate IQGAPs";"COPI-mediated anterograde transport"
XP_046410953.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_046432444.1	6	Reactome: R-HSA-977347;KEGG: 00680+2.6.1.52;KEGG: 00270+2.6.1.52;MetaCyc: PWY-8010;KEGG: 00260+2.6.1.52;KEGG: 00750+2.6.1.52	"Serine biosynthesis";"Methane metabolism";"Cysteine and methionine metabolism";"L-cysteine biosynthesis IX (Trichomonas vaginalis)";"Glycine, serine and threonine metabolism";"Vitamin B6 metabolism"
XP_046430673.1	1	Reactome: R-HSA-189451	"Heme biosynthesis"
XP_046428802.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_046417549.1	2	Reactome: R-HSA-936837;Reactome: R-HSA-6798695	"Ion transport by P-type ATPases";"Neutrophil degranulation"
XP_046420924.1	16	Reactome: R-HSA-975957;Reactome: R-HSA-156902;Reactome: R-HSA-72764;Reactome: R-HSA-72649;Reactome: R-HSA-72689;Reactome: R-HSA-192823;Reactome: R-HSA-72695;Reactome: R-HSA-1799339;Reactome: R-HSA-6791226;Reactome: R-HSA-72702;Reactome: R-HSA-975956;Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-2408557;Reactome: R-HSA-72706	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Peptide chain elongation";"Eukaryotic Translation Termination";"Translation initiation complex formation";"Formation of a pool of free 40S subunits";"Viral mRNA Translation";"Formation of the ternary complex, and subsequently, the 43S complex";"SRP-dependent cotranslational protein targeting to membrane";"Major pathway of rRNA processing in the nucleolus and cytosol";"Ribosomal scanning and start codon recognition";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Selenocysteine synthesis";"GTP hydrolysis and joining of the 60S ribosomal subunit"
XP_046428885.1	20	MetaCyc: PWY-5136;KEGG: 00410+1.3.3.6;Reactome: R-HSA-9033241;MetaCyc: PWY-6837;MetaCyc: PWY-735;KEGG: 00640+1.3.3.6;KEGG: 00592+1.3.3.6;KEGG: 00071+1.3.3.6;MetaCyc: PWY-7338;MetaCyc: PWY-6920;MetaCyc: PWY-7858;MetaCyc: PWY-7291;MetaCyc: PWY-7337;MetaCyc: PWY-7574;MetaCyc: PWY-7340;MetaCyc: PWY-7288;MetaCyc: PWY-7726;MetaCyc: PWY-7606;MetaCyc: PWY-7854;MetaCyc: PWY-7007	"Fatty acid beta-oxidation II (plant peroxisome)";"beta-Alanine metabolism";"Peroxisomal protein import";"Fatty acid beta-oxidation V (unsaturated, odd number, di-isomerase-dependent)";"Jasmonic acid biosynthesis";"Propanoate metabolism";"alpha-Linolenic acid metabolism";"Fatty acid degradation";"10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast)";"6-gingerol analog biosynthesis (engineered)";"(5Z)-dodecenoate biosynthesis II";"Oleate beta-oxidation (isomerase-dependent, yeast)";"10-cis-heptadecenoyl-CoA degradation (yeast)";"Propanoyl-coa degradation II";"9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast)";"Fatty acid beta-oxidation VII (yeast peroxisome)";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Crotonyl-coa/ethylmalonyl-coa/hydroxybutyryl-coa cycle (engineered)";"Methyl ketone biosynthesis (engineered)"
XP_046415857.1	5	KEGG: 00790+1.5.1.3;KEGG: 00670+1.5.1.3;Reactome: R-HSA-196757;MetaCyc: PWY-3841;MetaCyc: PWY-6614	"Folate biosynthesis";"One carbon pool by folate";"Metabolism of folate and pterines";"Folate transformations II (plants)";"Tetrahydrofolate biosynthesis"
XP_046435738.1	12	Reactome: R-HSA-1442490;Reactome: R-HSA-2691232;Reactome: R-HSA-982772;Reactome: R-HSA-2644606;Reactome: R-HSA-5362798;Reactome: R-HSA-2660826;Reactome: R-HSA-2894862;Reactome: R-HSA-2122948;Reactome: R-HSA-75893;Reactome: R-HSA-193692;Reactome: R-HSA-177929;Reactome: R-HSA-1251985	"Collagen degradation";"Constitutive Signaling by NOTCH1 HD Domain Mutants";"Growth hormone receptor signaling";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Release of Hh-Np from the secreting cell";"Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Activated NOTCH1 Transmits Signal to the Nucleus";"TNF signaling";"Regulated proteolysis of p75NTR";"Signaling by EGFR";"Nuclear signaling by ERBB4"
XP_046409606.1	9	MetaCyc: PWY-8004;MetaCyc: PWY-6901;Reactome: R-HSA-70263;KEGG: 00010+1.2.1.12;MetaCyc: PWY-5484;MetaCyc: PWY-7003;KEGG: 00710+1.2.1.12;Reactome: R-HSA-70171;MetaCyc: PWY-1042	"Entner-Doudoroff pathway I";"Superpathway of glucose and xylose degradation";"Gluconeogenesis";"Glycolysis / Gluconeogenesis";"Glycolysis II (from fructose 6-phosphate)";"Glycerol degradation to butanol";"Carbon fixation in photosynthetic organisms";"Glycolysis";"Glycolysis IV (plant cytosol)"
XP_046427009.1	1	KEGG: 00230+4.6.1.2	"Purine metabolism"
XP_046419726.1	6	Reactome: R-HSA-141444;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813;Reactome: R-HSA-68877;Reactome: R-HSA-2500257;Reactome: R-HSA-5663220	"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids";"Mitotic Prometaphase";"Resolution of Sister Chromatid Cohesion";"RHO GTPases Activate Formins"
XP_046422271.1	4	Reactome: R-HSA-9020702;Reactome: R-HSA-937039;Reactome: R-HSA-975144;MetaCyc: PWY-7511	"Interleukin-1 signaling";"IRAK1 recruits IKK complex";"IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation";"Protein ubiquitination"
XP_046434315.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_046411063.1	2	Reactome: R-HSA-5689880;Reactome: R-HSA-1632852	"Ub-specific processing proteases";"Macroautophagy"
XP_046413724.1	3	MetaCyc: PWY-6807;KEGG: 00511+3.2.1.51;Reactome: R-HSA-6798695	"Xyloglucan degradation II (exoglucanase)";"Other glycan degradation";"Neutrophil degranulation"
XP_046414414.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046415550.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046413873.1	3	Reactome: R-HSA-6811438;Reactome: R-HSA-6807878;Reactome: R-HSA-6811440	"Intra-Golgi traffic";"COPI-mediated anterograde transport";"Retrograde transport at the Trans-Golgi-Network"
XP_046410856.1	4	Reactome: R-HSA-73856;Reactome: R-HSA-72187;Reactome: R-HSA-159236;Reactome: R-HSA-72163	"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"mRNA Splicing - Major Pathway"
XP_046412144.1	1	Reactome: R-HSA-9616222	"Transcriptional regulation of granulopoiesis"
XP_046419498.1	3	Reactome: R-HSA-8874081;Reactome: R-HSA-3000171;Reactome: R-HSA-3000157	"MET activates PTK2 signaling";"Non-integrin membrane-ECM interactions";"Laminin interactions"
XP_046424526.1	4	Reactome: R-HSA-9614399;Reactome: R-HSA-5674400;Reactome: R-HSA-198693;Reactome: R-HSA-9615017	"Regulation of localization of FOXO transcription factors";"Constitutive Signaling by AKT1 E17K in Cancer";"AKT phosphorylates targets in the nucleus";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes"
XP_046419002.1	2	Reactome: R-HSA-5357956;Reactome: R-HSA-5357905	"TNFR1-induced NFkappaB signaling pathway";"Regulation of TNFR1 signaling"
XP_046433127.1	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
XP_046423563.1	1	Reactome: R-HSA-6784531	"tRNA processing in the nucleus"
XP_046428554.1	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
XP_046416644.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046415753.1	7	KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1	"Thermogenesis";"Human cytomegalovirus infection";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Relaxin signaling pathway";"mTOR signaling pathway";"PI3K-Akt signaling pathway"
XP_046416806.1	2	Reactome: R-HSA-8949664;Reactome: R-HSA-8949215	"Processing of SMDT1";"Mitochondrial calcium ion transport"
XP_046419659.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046425920.1	16	Reactome: R-HSA-192823;Reactome: R-HSA-72689;Reactome: R-HSA-1799339;Reactome: R-HSA-72695;Reactome: R-HSA-975957;Reactome: R-HSA-72764;Reactome: R-HSA-72649;Reactome: R-HSA-156902;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-2408557;Reactome: R-HSA-72706;Reactome: R-HSA-6791226;Reactome: R-HSA-975956;Reactome: R-HSA-72702	"Viral mRNA Translation";"Formation of a pool of free 40S subunits";"SRP-dependent cotranslational protein targeting to membrane";"Formation of the ternary complex, and subsequently, the 43S complex";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Translation initiation complex formation";"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Selenocysteine synthesis";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Ribosomal scanning and start codon recognition"
XP_046426795.1	4	KEGG: 00730+2.7.4.3;MetaCyc: PWY-7219;KEGG: 00230+2.7.4.3;Reactome: R-HSA-499943	"Thiamine metabolism";"Adenosine ribonucleotides de novo biosynthesis";"Purine metabolism";"Interconversion of nucleotide di- and triphosphates"
XP_046431845.1	2	Reactome: R-HSA-3214858;Reactome: R-HSA-8939243	"RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"
XP_046416657.1	1	Reactome: R-HSA-6794361	"Neurexins and neuroligins"
XP_046436205.1	10	Reactome: R-HSA-111459;Reactome: R-HSA-9627069;Reactome: R-HSA-111457;Reactome: R-HSA-3299685;Reactome: R-HSA-2151201;Reactome: R-HSA-111463;Reactome: R-HSA-111464;Reactome: R-HSA-111458;Reactome: R-HSA-5628897;Reactome: R-HSA-611105	"Activation of caspases through apoptosome-mediated cleavage";"Regulation of the apoptosome activity";"Release of apoptotic factors from the mitochondria";"Detoxification of Reactive Oxygen Species";"Transcriptional activation of mitochondrial biogenesis";"SMAC (DIABLO) binds to IAPs";"SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes";"Formation of apoptosome";"TP53 Regulates Metabolic Genes";"Respiratory electron transport"
XP_046435083.1	7	KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1	"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Thermogenesis";"Human cytomegalovirus infection";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Relaxin signaling pathway"
XP_046413517.1	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
XP_046416476.1	179	Reactome: R-HSA-937042;Reactome: R-HSA-9020702;Reactome: R-HSA-6782210;Reactome: R-HSA-72689;Reactome: R-HSA-209543;Reactome: R-HSA-2173791;Reactome: R-HSA-8849469;Reactome: R-HSA-209560;Reactome: R-HSA-4641258;Reactome: R-HSA-5632684;Reactome: R-HSA-9633012;Reactome: R-HSA-9604323;Reactome: R-HSA-937072;Reactome: R-HSA-69601;Reactome: R-HSA-195253;Reactome: R-HSA-5689901;Reactome: R-HSA-6804760;Reactome: R-HSA-69541;Reactome: R-HSA-975110;Reactome: R-HSA-901032;Reactome: R-HSA-2122948;Reactome: R-HSA-1169091;Reactome: R-HSA-9014325;Reactome: R-HSA-2559580;Reactome: R-HSA-8875360;Reactome: R-HSA-5689877;Reactome: R-HSA-75815;Reactome: R-HSA-2644606;Reactome: R-HSA-8856825;Reactome: R-HSA-9615710;Reactome: R-HSA-156902;Reactome: R-HSA-5357956;Reactome: R-HSA-6782135;Reactome: R-HSA-110314;Reactome: R-HSA-5696397;Reactome: R-HSA-5696394;Reactome: R-HSA-156827;Reactome: R-HSA-2173796;Reactome: R-HSA-8948747;Reactome: R-HSA-2559585;Reactome: R-HSA-936440;Reactome: R-HSA-1169408;Reactome: R-HSA-8854050;Reactome: R-HSA-6781823;Reactome: R-HSA-917937;Reactome: R-HSA-5689896;Reactome: R-HSA-9637628;Reactome: R-HSA-2173795;Reactome: R-HSA-174113;Reactome: R-HSA-180534;Reactome: R-HSA-6781827;Reactome: R-HSA-5696400;Reactome: R-HSA-174048;Reactome: R-HSA-68827;Reactome: R-HSA-5357905;Reactome: R-HSA-2979096;Reactome: R-HSA-5654732;Reactome: R-HSA-5689603;Reactome: R-HSA-5610783;Reactome: R-HSA-1234176;Reactome: R-HSA-211733;Reactome: R-HSA-174490;Reactome: R-HSA-5610780;Reactome: R-HSA-1295596;Reactome: R-HSA-5676590;Reactome: R-HSA-5358346;Reactome: R-HSA-6807004;Reactome: R-HSA-2672351;Reactome: R-HSA-2173788;Reactome: R-HSA-2559582;Reactome: R-HSA-6804756;Reactome: R-HSA-5654733;Reactome: R-HSA-9636383;Reactome: R-HSA-400253;Reactome: R-HSA-68949;Reactome: R-HSA-175474;Reactome: R-HSA-5689880;Reactome: R-HSA-4641257;Reactome: R-HSA-180585;Reactome: R-HSA-5675221;Reactome: R-HSA-162588;Reactome: R-HSA-72764;Reactome: R-HSA-8866654;Reactome: R-HSA-5684264;Reactome: R-HSA-72706;Reactome: R-HSA-2691232;Reactome: R-HSA-5607761;Reactome: R-HSA-9033241;Reactome: R-HSA-5656169;Reactome: R-HSA-8939902;Reactome: R-HSA-6791226;Reactome: R-HSA-937041;Reactome: R-HSA-9645460;Reactome: R-HSA-205043;Reactome: R-HSA-6804757;Reactome: R-HSA-3134975;Reactome: R-HSA-5687128;Reactome: R-HSA-2122947;Reactome: R-HSA-8863795;Reactome: R-HSA-182971;Reactome: R-HSA-69481;Reactome: R-HSA-977225;Reactome: R-HSA-8948751;Reactome: R-HSA-2408557;Reactome: R-HSA-450408;Reactome: R-HSA-1236974;Reactome: R-HSA-5654726;Reactome: R-HSA-9010553;Reactome: R-HSA-5668541;Reactome: R-HSA-975956;Reactome: R-HSA-5654727;Reactome: R-HSA-382556;Reactome: R-HSA-936964;Reactome: R-HSA-450321;Reactome: R-HSA-349425;Reactome: R-HSA-937039;Reactome: R-HSA-8951664;Reactome: R-HSA-174084;Reactome: R-HSA-202424;Reactome: R-HSA-4608870;Reactome: R-HSA-1253288;Reactome: R-HSA-3769402;Reactome: R-HSA-8856828;Reactome: R-HSA-5610785;Reactome: R-HSA-5678895;Reactome: R-HSA-3322077;Reactome: R-HSA-110320;Reactome: R-HSA-450302;Reactome: R-HSA-9646399;Reactome: R-HSA-3785653;Reactome: R-HSA-6783310;Reactome: R-HSA-983168;Reactome: R-HSA-168927;Reactome: R-HSA-69231;Reactome: R-HSA-5693565;Reactome: R-HSA-5655862;Reactome: R-HSA-917729;Reactome: R-HSA-174154;Reactome: R-HSA-2894862;Reactome: R-HSA-5675482;Reactome: R-HSA-1799339;Reactome: R-HSA-201681;Reactome: R-HSA-168638;Reactome: R-HSA-1236382;Reactome: R-HSA-187577;Reactome: R-HSA-5607764;Reactome: R-HSA-445989;Reactome: R-HSA-8866652;Reactome: R-HSA-975957;Reactome: R-HSA-8852276;Reactome: R-HSA-2565942;Reactome: R-HSA-912631;Reactome: R-HSA-5656121;Reactome: R-HSA-532668;Reactome: R-HSA-9613829;Reactome: R-HSA-4641263;Reactome: R-HSA-8941858;Reactome: R-HSA-5362768;Reactome: R-HSA-69017;Reactome: R-HSA-174178;Reactome: R-HSA-2871837;Reactome: R-HSA-9013973;Reactome: R-HSA-5685942;Reactome: R-HSA-5693607;Reactome: R-HSA-192823;Reactome: R-HSA-1358803;Reactome: R-HSA-168928;Reactome: R-HSA-8876493;Reactome: R-HSA-179409;Reactome: R-HSA-8939236;Reactome: R-HSA-110312;Reactome: R-HSA-5658442;Reactome: R-HSA-975163;Reactome: R-HSA-975144;Reactome: R-HSA-174184;Reactome: R-HSA-2467813;Reactome: R-HSA-5205685;Reactome: R-HSA-9013507;Reactome: R-HSA-5696395	"IRAK2 mediated activation of TAK1 complex";"Interleukin-1 signaling";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Formation of a pool of free 40S subunits";"p75NTR recruits signalling complexes";"TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)";"PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1";"NF-kB is activated and signals survival";"Degradation of DVL";"Hedgehog 'on' state";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Negative regulation of NOTCH4 signaling";"TRAF6-mediated induction of TAK1 complex within TLR4 complex";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Degradation of beta-catenin by the destruction complex";"Metalloprotease DUBs";"Regulation of TP53 Activity through Methylation";"Stabilization of p53";"TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling";"ER Quality Control Compartment (ERQC)";"Activated NOTCH1 Transmits Signal to the Nucleus";"Activation of NF-kappaB in B cells";"TICAM1,TRAF6-dependent induction of TAK1 complex";"Oxidative Stress Induced Senescence";"InlB-mediated entry of Listeria monocytogenes into host cell";"Josephin domain DUBs";"Ubiquitin-dependent degradation of Cyclin D";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Cargo recognition for clathrin-mediated endocytosis";"Late endosomal microautophagy";"Peptide chain elongation";"TNFR1-induced NFkappaB signaling pathway";"Dual incision in TC-NER";"Recognition of DNA damage by PCNA-containing replication complex";"Gap-filling DNA repair synthesis and ligation in GG-NER";"DNA Damage Recognition in GG-NER";"L13a-mediated translational silencing of Ceruloplasmin expression";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"Regulation of PTEN localization";"Oncogene Induced Senescence";"Negative regulators of DDX58/IFIH1 signaling";"ISG15 antiviral mechanism";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Formation of TC-NER Pre-Incision Complex";"Iron uptake and transport";"Ovarian tumor domain proteases";"Modulation by Mtb of host immune system";"Downregulation of SMAD2/3:SMAD4 transcriptional activity";"SCF-beta-TrCP mediated degradation of Emi1";"Vpu mediated degradation of CD4";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Dual Incision in GG-NER";"APC/C:Cdc20 mediated degradation of Cyclin B";"CDT1 association with the CDC6:ORC:origin complex";"Regulation of TNFR1 signaling";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Negative regulation of FGFR3 signaling";"UCH proteinases";"Degradation of GLI2 by the proteasome";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Membrane binding and targetting of GAG proteins";"Degradation of GLI1 by the proteasome";"Spry regulation of FGF signaling";"NIK-->noncanonical NF-kB signaling";"Hedgehog ligand biogenesis";"Negative regulation of MET activity";"Stimuli-sensing channels";"Downregulation of TGF-beta receptor signaling";"Senescence-Associated Secretory Phenotype (SASP)";"Regulation of TP53 Activity through Phosphorylation";"Negative regulation of FGFR4 signaling";"Prevention of phagosomal-lysosomal fusion";"Circadian Clock";"Orc1 removal from chromatin";"Assembly Of The HIV Virion";"Ub-specific processing proteases";"Degradation of AXIN";"Vif-mediated degradation of APOBEC3G";"Negative regulation of MAPK pathway";"Budding and maturation of HIV virion";"Eukaryotic Translation Termination";"E3 ubiquitin ligases ubiquitinate target proteins";"MAP3K8 (TPL2)-dependent MAPK1/3 activation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Constitutive Signaling by NOTCH1 HD Domain Mutants";"Dectin-1 mediated noncanonical NF-kB signaling";"Peroxisomal protein import";"Termination of translesion DNA synthesis";"Regulation of RUNX2 expression and activity";"Major pathway of rRNA processing in the nucleolus and cytosol";"IKK complex recruitment mediated by RIP1";"Alpha-protein kinase 1 signaling pathway";"NRIF signals cell death from the nucleus";"Regulation of TP53 Degradation";"Regulation of innate immune responses to cytosolic DNA";"MAPK6/MAPK4 signaling";"NOTCH1 Intracellular Domain Regulates Transcription";"Downregulation of ERBB2 signaling";"EGFR downregulation";"G2/M Checkpoints";"Amyloid fiber formation";"Regulation of PTEN stability and activity";"Selenocysteine synthesis";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"ER-Phagosome pathway";"Negative regulation of FGFR1 signaling";"Regulation of expression of SLITs and ROBOs";"TNFR2 non-canonical NF-kB pathway";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Negative regulation of FGFR2 signaling";"ABC-family proteins mediated transport";"Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon";"JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1";"Autodegradation of the E3 ubiquitin ligase COP1";"IRAK1 recruits IKK complex";"Neddylation";"Autodegradation of Cdh1 by Cdh1:APC/C";"Downstream TCR signaling";"Asymmetric localization of PCP proteins";"Downregulation of ERBB4 signaling";"Deactivation of the beta-catenin transactivating complex";"Clathrin-mediated endocytosis";"GLI3 is processed to GLI3R by the proteasome";"Defective CFTR causes cystic fibrosis";"Glycogen synthesis";"Translesion Synthesis by POLH";"activated TAK1 mediates p38 MAPK activation";"Aggrephagy";"Myoclonic epilepsy of Lafora";"Fanconi Anemia Pathway";"Antigen processing: Ubiquitination & Proteasome degradation";"TICAM1, RIP1-mediated IKK complex recruitment";"Cyclin D associated events in G1";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Translesion synthesis by POLK";"Endosomal Sorting Complex Required For Transport (ESCRT)";"APC/C:Cdc20 mediated degradation of Securin";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Regulation of necroptotic cell death";"SRP-dependent cotranslational protein targeting to membrane";"TCF dependent signaling in response to WNT";"NOD1/2 Signaling Pathway";"Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants";"SCF(Skp2)-mediated degradation of p27/p21";"CLEC7A (Dectin-1) signaling";"TAK1 activates NFkB by phosphorylation and activation of IKKs complex";"Synthesis of active ubiquitin: roles of E1 and E2 enzymes";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Regulation of PLK1 Activity at G2/M Transition";"Regulation of signaling by CBL";"Translesion synthesis by POLI";"N-glycan trimming in the ER and Calnexin/Calreticulin cycle";"Chaperone Mediated Autophagy";"Regulation of FZD by ubiquitination";"Regulation of RUNX3 expression and activity";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"CDK-mediated phosphorylation and removal of Cdc6";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"FCERI mediated NF-kB activation";"TICAM1-dependent activation of IRF3/IRF7";"HDR through Homologous Recombination (HRR)";"Processing of DNA double-strand break ends";"Viral mRNA Translation";"Downregulation of ERBB2:ERBB3 signaling";"DDX58/IFIH1-mediated induction of interferon-alpha/beta";"InlA-mediated entry of Listeria monocytogenes into host cells";"APC-Cdc20 mediated degradation of Nek2A";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Translesion synthesis by REV1";"Regulation of RAS by GAPs";"IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation";"IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Separation of Sister Chromatids";"Pink/Parkin Mediated Mitophagy";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Formation of Incision Complex in GG-NER"
XP_046424190.1	12	MetaCyc: PWY-6527;KEGG: 00040+2.7.7.9;Reactome: R-HSA-173599;KEGG: 00500+2.7.7.9;KEGG: 00561+2.7.7.9;MetaCyc: PWY-3801;Reactome: R-HSA-3322077;MetaCyc: PWY-7238;MetaCyc: PWY-7817;MetaCyc: PWY-7343;KEGG: 00052+2.7.7.9;KEGG: 00520+2.7.7.9	"Stachyose degradation";"Pentose and glucuronate interconversions";"Formation of the active cofactor, UDP-glucuronate";"Starch and sucrose metabolism";"Glycerolipid metabolism";"Sucrose degradation II (sucrose synthase)";"Glycogen synthesis";"Sucrose biosynthesis II";"Type I lipoteichoic acid biosynthesis (S. aureus)";"UDP-alpha-D-glucose biosynthesis I";"Galactose metabolism";"Amino sugar and nucleotide sugar metabolism"
XP_046409400.1	3	Reactome: R-HSA-73621;Reactome: R-HSA-196807;Reactome: R-HSA-74259	"Pyrimidine catabolism";"Nicotinate metabolism";"Purine catabolism"
XP_046430165.1	7	KEGG: 00983+2.7.4.14;Reactome: R-HSA-499943;MetaCyc: PWY-7176;KEGG: 00230+2.7.4.3;KEGG: 00240+2.7.4.14;MetaCyc: PWY-7219;KEGG: 00730+2.7.4.3	"Drug metabolism - other enzymes";"Interconversion of nucleotide di- and triphosphates";"UTP and CTP de novo biosynthesis";"Purine metabolism";"Pyrimidine metabolism";"Adenosine ribonucleotides de novo biosynthesis";"Thiamine metabolism"
XP_046419243.1	5	Reactome: R-HSA-6811434;Reactome: R-HSA-1445148;Reactome: R-HSA-983189;Reactome: R-HSA-2132295;Reactome: R-HSA-5620924	"COPI-dependent Golgi-to-ER retrograde traffic";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Kinesins";"MHC class II antigen presentation";"Intraflagellar transport"
XP_046419798.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046415719.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_046409620.1	5	MetaCyc: PWY-5981;MetaCyc: PWY-5667;MetaCyc: PWY-7817;KEGG: 00564+2.7.7.41;KEGG: 04070+2.7.7.41	"CDP-diacylglycerol biosynthesis III";"CDP-diacylglycerol biosynthesis I";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Glycerophospholipid metabolism";"Phosphatidylinositol signaling system"
XP_046435876.1	3	Reactome: R-HSA-445095;Reactome: R-HSA-8963901;Reactome: R-HSA-6807878	"Interaction between L1 and Ankyrins";"Chylomicron remodeling";"COPI-mediated anterograde transport"
XP_046410267.1	2	MetaCyc: PWY-5386;KEGG: 00620+3.1.2.6	"Methylglyoxal degradation I";"Pyruvate metabolism"
XP_046415421.1	2	Reactome: R-HSA-5578998;Reactome: R-HSA-174403	"Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD)";"Glutathione synthesis and recycling"
XP_046410325.1	1	Reactome: R-HSA-432722	"Golgi Associated Vesicle Biogenesis"
XP_046433847.1	1	Reactome: R-HSA-1474228	"Degradation of the extracellular matrix"
XP_046421033.1	2	Reactome: R-HSA-418890;Reactome: R-HSA-3295583	"Role of second messengers in netrin-1 signaling";"TRP channels"
XP_046426897.1	2	Reactome: R-HSA-1268020;Reactome: R-HSA-1482798	"Mitochondrial protein import";"Acyl chain remodeling of CL"
XP_046424513.1	1	Reactome: R-HSA-1445148	"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
XP_046433458.1	2	Reactome: R-HSA-204005;Reactome: R-HSA-8876198	"COPII-mediated vesicle transport";"RAB GEFs exchange GTP for GDP on RABs"
XP_046423927.1	6	MetaCyc: PWY-7782;MetaCyc: PWY-5884;MetaCyc: PWY-6733;Reactome: R-HSA-9640463;KEGG: 00073+1.2.1.84;MetaCyc: PWY-7656	"Plasmalogen biosynthesis";"Wax esters biosynthesis I";"Sporopollenin precursors biosynthesis";"Wax biosynthesis";"Cutin, suberine and wax biosynthesis";"Spodoptera littoralis pheromone biosynthesis"
XP_046416341.1	1	Reactome: R-HSA-1483255	"PI Metabolism"
XP_046427477.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_046412108.1	17	Reactome: R-HSA-8953750;Reactome: R-HSA-9616222;Reactome: R-HSA-113501;Reactome: R-HSA-1362300;Reactome: R-HSA-69202;Reactome: R-HSA-69656;Reactome: R-HSA-2559580;Reactome: R-HSA-69205;Reactome: R-HSA-1362277;Reactome: R-HSA-139915;Reactome: R-HSA-2559585;Reactome: R-HSA-6804114;Reactome: R-HSA-1912408;Reactome: R-HSA-111448;Reactome: R-HSA-2173796;Reactome: R-HSA-1538133;Reactome: R-HSA-69231	"Transcriptional Regulation by E2F6";"Transcriptional regulation of granulopoiesis";"Inhibition of replication initiation of damaged DNA by RB1/E2F1";"Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1";"Cyclin E associated events during G1/S transition";"Cyclin A:Cdk2-associated events at S phase entry";"Oxidative Stress Induced Senescence";"G1/S-Specific Transcription";"Transcription of E2F targets under negative control by DREAM complex";"Activation of PUMA and translocation to mitochondria";"Oncogene Induced Senescence";"TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest";"Pre-NOTCH Transcription and Translation";"Activation of NOXA and translocation to mitochondria";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"G0 and Early G1";"Cyclin D associated events in G1"
XP_046427117.1	1	Reactome: R-HSA-111465	"Apoptotic cleavage of cellular proteins"
XP_046420006.1	11	KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;Reactome: R-HSA-3270619;KEGG: 04151+2.7.11.1;Reactome: R-HSA-5693571;Reactome: R-HSA-1834949;KEGG: 04926+2.7.11.1;Reactome: R-HSA-8866654;KEGG: 05163+2.7.11.1	"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Thermogenesis";"mTOR signaling pathway";"IRF3-mediated induction of type I IFN";"PI3K-Akt signaling pathway";"Nonhomologous End-Joining (NHEJ)";"Cytosolic sensors of pathogen-associated DNA";"Relaxin signaling pathway";"E3 ubiquitin ligases ubiquitinate target proteins";"Human cytomegalovirus infection"
XP_046417738.1	2	Reactome: R-HSA-202733;Reactome: R-HSA-416993	"Cell surface interactions at the vascular wall";"Trafficking of GluR2-containing AMPA receptors"
XP_046415425.1	6	Reactome: R-HSA-210500;Reactome: R-HSA-181429;Reactome: R-HSA-388844;Reactome: R-HSA-212676;Reactome: R-HSA-264642;Reactome: R-HSA-181430	"Glutamate Neurotransmitter Release Cycle";"Serotonin Neurotransmitter Release Cycle";"Receptor-type tyrosine-protein phosphatases";"Dopamine Neurotransmitter Release Cycle";"Acetylcholine Neurotransmitter Release Cycle";"Norepinephrine Neurotransmitter Release Cycle"
XP_046418883.1	8	Reactome: R-HSA-164378;Reactome: R-HSA-432040;Reactome: R-HSA-983231;Reactome: R-HSA-163615;Reactome: R-HSA-381676;Reactome: R-HSA-180024;Reactome: R-HSA-442720;Reactome: R-HSA-5610787	"PKA activation in glucagon signalling";"Vasopressin regulates renal water homeostasis via Aquaporins";"Factors involved in megakaryocyte development and platelet production";"PKA activation";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"DARPP-32 events";"CREB1 phosphorylation through the activation of Adenylate Cyclase";"Hedgehog 'off' state"
XP_046433521.1	1	Reactome: R-HSA-391908	"Prostanoid ligand receptors"
XP_046433403.1	9	MetaCyc: PWY-5664;KEGG: 00790+3.5.4.16;MetaCyc: PWY-6147;MetaCyc: PWY-7442;Reactome: R-HSA-1474151;MetaCyc: PWY-6703;MetaCyc: PWY-5663;MetaCyc: PWY-6983;MetaCyc: PWY-7852	"Erythro-tetrahydrobiopterin biosynthesis II";"Folate biosynthesis";"6-hydroxymethyl-dihydropterin diphosphate biosynthesis I";"Drosopterin and aurodrosopterin biosynthesis";"Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation";"Preq0 biosynthesis";"Erythro-tetrahydrobiopterin biosynthesis I";"Threo-tetrahydrobiopterin biosynthesis";"6-hydroxymethyl-dihydropterin diphosphate biosynthesis IV (Plasmodium)"
XP_046427217.1	1	Reactome: R-HSA-2470946	"Cohesin Loading onto Chromatin"
XP_046427481.1	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_046411163.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046417113.1	4	KEGG: 00270+2.5.1.6;Reactome: R-HSA-156581;MetaCyc: PWY-5912;MetaCyc: PWY-5041	"Cysteine and methionine metabolism";"Methylation";"2'-deoxymugineic acid phytosiderophore biosynthesis";"S-adenosyl-L-methionine cycle II"
XP_046415180.1	2	MetaCyc: PWY-7221;KEGG: 00230+2.7.4.8	"Guanosine ribonucleotides de novo biosynthesis";"Purine metabolism"
XP_046422661.1	4	Reactome: R-HSA-159236;Reactome: R-HSA-72187;Reactome: R-HSA-72163;Reactome: R-HSA-73856	"Transport of Mature mRNA derived from an Intron-Containing Transcript";"mRNA 3'-end processing";"mRNA Splicing - Major Pathway";"RNA Polymerase II Transcription Termination"
XP_046433149.1	1	Reactome: R-HSA-1632852	"Macroautophagy"
XP_046431843.1	2	Reactome: R-HSA-8939243;Reactome: R-HSA-3214858	"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RMTs methylate histone arginines"
XP_046430258.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_046425149.1	1	Reactome: R-HSA-418990	"Adherens junctions interactions"
XP_046411883.1	8	KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05163+2.7.11.1;Reactome: R-HSA-6791226;KEGG: 04926+2.7.11.1	"Thermogenesis";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Human cytomegalovirus infection";"Major pathway of rRNA processing in the nucleolus and cytosol";"Relaxin signaling pathway"
XP_046420593.1	2	Reactome: R-HSA-71403;Reactome: R-HSA-611105	"Citric acid cycle (TCA cycle)";"Respiratory electron transport"
XP_046410636.1	7	Reactome: R-HSA-5696400;Reactome: R-HSA-5685939;Reactome: R-HSA-110362;Reactome: R-HSA-2173795;Reactome: R-HSA-5696395;Reactome: R-HSA-5696394;Reactome: R-HSA-3108214	"Dual Incision in GG-NER";"HDR through MMEJ (alt-NHEJ)";"POLB-Dependent Long Patch Base Excision Repair";"Downregulation of SMAD2/3:SMAD4 transcriptional activity";"Formation of Incision Complex in GG-NER";"DNA Damage Recognition in GG-NER";"SUMOylation of DNA damage response and repair proteins"
XP_046431167.1	7	KEGG: 00220+3.5.3.1;Reactome: R-HSA-70635;MetaCyc: PWY-31;KEGG: 00330+3.5.3.1;MetaCyc: PWY-6922;MetaCyc: PWY-4984;MetaCyc: PWY-46	"Arginine biosynthesis";"Urea cycle";"Canavanine degradation";"Arginine and proline metabolism";"L-Ndelta-acetylornithine biosynthesis";"Urea cycle";"Putrescine biosynthesis III"
XP_046410104.1	10	MetaCyc: PWY-7394;MetaCyc: PWY-7849;KEGG: 00230+3.5.2.17;Reactome: R-HSA-6798695;Reactome: R-HSA-2453902;Reactome: R-HSA-975634;Reactome: R-HSA-977225;Reactome: R-HSA-2453864;Reactome: R-HSA-3000171;MetaCyc: PWY-5691	"Urate conversion to allantoin II";"Urate conversion to allantoin III";"Purine metabolism";"Neutrophil degranulation";"The canonical retinoid cycle in rods (twilight vision)";"Retinoid metabolism and transport";"Amyloid fiber formation";"Retinoid cycle disease events";"Non-integrin membrane-ECM interactions";"Urate conversion to allantoin I"
XP_046427215.1	5	Reactome: R-HSA-6804758;Reactome: R-HSA-73762;Reactome: R-HSA-427389;Reactome: R-HSA-3214815;Reactome: R-HSA-8943724	"Regulation of TP53 Activity through Acetylation";"RNA Polymerase I Transcription Initiation";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"HDACs deacetylate histones";"Regulation of PTEN gene transcription"
XP_046424585.1	7	Reactome: R-HSA-198323;Reactome: R-HSA-5628897;Reactome: R-HSA-5674400;Reactome: R-HSA-380972;Reactome: R-HSA-8854214;Reactome: R-HSA-165181;Reactome: R-HSA-1632852	"AKT phosphorylates targets in the cytosol";"TP53 Regulates Metabolic Genes";"Constitutive Signaling by AKT1 E17K in Cancer";"Energy dependent regulation of mTOR by LKB1-AMPK";"TBC/RABGAPs";"Inhibition of TSC complex formation by PKB";"Macroautophagy"
XP_046432221.1	5	Reactome: R-HSA-674695;Reactome: R-HSA-75955;Reactome: R-HSA-112382;Reactome: R-HSA-8866654;Reactome: R-HSA-201722	"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Elongation";"Formation of RNA Pol II elongation complex";"E3 ubiquitin ligases ubiquitinate target proteins";"Formation of the beta-catenin:TCF transactivating complex"
XP_046418478.1	1	Reactome: R-HSA-8854214	"TBC/RABGAPs"
XP_046428547.1	2	Reactome: R-HSA-6804756;Reactome: R-HSA-8854518	"Regulation of TP53 Activity through Phosphorylation";"AURKA Activation by TPX2"
XP_046415721.1	1	Reactome: R-HSA-5576886	"Phase 4 - resting membrane potential"
XP_046421197.1	2	Reactome: R-HSA-381340;Reactome: R-HSA-1989781	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression"
XP_046427619.1	1	Reactome: R-HSA-3214842	"HDMs demethylate histones"
XP_046428269.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_046419075.1	1	Reactome: R-HSA-5658442	"Regulation of RAS by GAPs"
XP_046414744.1	1	Reactome: R-HSA-425986	"Sodium/Proton exchangers"
XP_046434950.1	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
XP_046433354.1	1	Reactome: R-HSA-216083	"Integrin cell surface interactions"
XP_046426502.1	7	KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1	"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Relaxin signaling pathway";"Thermogenesis";"Human cytomegalovirus infection";"mTOR signaling pathway";"PI3K-Akt signaling pathway"
XP_046430444.1	5	Reactome: R-HSA-4641257;Reactome: R-HSA-8948751;Reactome: R-HSA-5689880;Reactome: R-HSA-201681;Reactome: R-HSA-5545619	"Degradation of AXIN";"Regulation of PTEN stability and activity";"Ub-specific processing proteases";"TCF dependent signaling in response to WNT";"XAV939 inhibits tankyrase, stabilizing AXIN"
XP_046409940.1	2	Reactome: R-HSA-71403;Reactome: R-HSA-611105	"Citric acid cycle (TCA cycle)";"Respiratory electron transport"
XP_046434625.1	1	Reactome: R-HSA-1362409	"Mitochondrial iron-sulfur cluster biogenesis"
XP_046426580.1	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
XP_046420369.1	1	Reactome: R-HSA-70350	"Fructose catabolism"
XP_046434273.1	5	Reactome: R-HSA-5205685;Reactome: R-HSA-209560;Reactome: R-HSA-209543;Reactome: R-HSA-205043;Reactome: R-HSA-9020702	"Pink/Parkin Mediated Mitophagy";"NF-kB is activated and signals survival";"p75NTR recruits signalling complexes";"NRIF signals cell death from the nucleus";"Interleukin-1 signaling"
XP_046434133.1	2	Reactome: R-HSA-6784531;Reactome: R-HSA-6785470	"tRNA processing in the nucleus";"tRNA processing in the mitochondrion"
XP_046410280.1	2	Reactome: R-HSA-6804115;Reactome: R-HSA-429947	"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Deadenylation of mRNA"
XP_046421482.1	8	Reactome: R-HSA-165159;Reactome: R-HSA-380972;Reactome: R-HSA-166208;Reactome: R-HSA-6798695;Reactome: R-HSA-1632852;Reactome: R-HSA-9639288;Reactome: R-HSA-8943724;Reactome: R-HSA-5628897	"mTOR signalling";"Energy dependent regulation of mTOR by LKB1-AMPK";"mTORC1-mediated signalling";"Neutrophil degranulation";"Macroautophagy";"Amino acids regulate mTORC1";"Regulation of PTEN gene transcription";"TP53 Regulates Metabolic Genes"
XP_046431338.1	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
XP_046419330.1	4	Reactome: R-HSA-8856828;Reactome: R-HSA-6794361;Reactome: R-HSA-5250958;Reactome: R-HSA-8856825	"Clathrin-mediated endocytosis";"Neurexins and neuroligins";"Toxicity of botulinum toxin type B (BoNT/B)";"Cargo recognition for clathrin-mediated endocytosis"
XP_046433274.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046418475.1	1	Reactome: R-HSA-8854214	"TBC/RABGAPs"
XP_046419302.1	2	Reactome: R-HSA-8866423;Reactome: R-HSA-8963888	"VLDL assembly";"Chylomicron assembly"
XP_046416225.1	1	Reactome: R-HSA-2514853	"Condensation of Prometaphase Chromosomes"
XP_046422079.1	3	Reactome: R-HSA-193648;Reactome: R-HSA-194840;Reactome: R-HSA-416482	"NRAGE signals death through JNK";"Rho GTPase cycle";"G alpha (12/13) signalling events"
XP_046414786.1	2	Reactome: R-HSA-379726;KEGG: 00970+6.1.1.1	"Mitochondrial tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis"
XP_046434257.1	3	Reactome: R-HSA-193648;Reactome: R-HSA-416482;Reactome: R-HSA-194840	"NRAGE signals death through JNK";"G alpha (12/13) signalling events";"Rho GTPase cycle"
XP_046424079.1	1	Reactome: R-HSA-5676934	"Protein repair"
XP_046426127.1	1	Reactome: R-HSA-5658442	"Regulation of RAS by GAPs"
XP_046435777.1	1	Reactome: R-HSA-390651	"Dopamine receptors"
XP_046412242.1	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276	"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination"
XP_046430891.1	2	Reactome: R-HSA-917729;Reactome: R-HSA-9610379	"Endosomal Sorting Complex Required For Transport (ESCRT)";"HCMV Late Events"
XP_046434426.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_046432968.1	1	Reactome: R-HSA-110362	"POLB-Dependent Long Patch Base Excision Repair"
XP_046412671.1	7	Reactome: R-HSA-380284;Reactome: R-HSA-5620912;Reactome: R-HSA-2565942;Reactome: R-HSA-380270;Reactome: R-HSA-380320;Reactome: R-HSA-380259;Reactome: R-HSA-8854518	"Loss of proteins required for interphase microtubule organization from the centrosome";"Anchoring of the basal body to the plasma membrane";"Regulation of PLK1 Activity at G2/M Transition";"Recruitment of mitotic centrosome proteins and complexes";"Recruitment of NuMA to mitotic centrosomes";"Loss of Nlp from mitotic centrosomes";"AURKA Activation by TPX2"
XP_046420913.1	2	Reactome: R-HSA-8936459;Reactome: R-HSA-3214841	"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"PKMTs methylate histone lysines"
XP_046435759.1	2	Reactome: R-HSA-3299685;KEGG: 00480+1.11.1.15	"Detoxification of Reactive Oxygen Species";"Glutathione metabolism"
XP_046421201.1	33	Reactome: R-HSA-167172;Reactome: R-HSA-69231;Reactome: R-HSA-73863;Reactome: R-HSA-6796648;Reactome: R-HSA-167200;Reactome: R-HSA-77075;Reactome: R-HSA-674695;Reactome: R-HSA-5696395;Reactome: R-HSA-167152;Reactome: R-HSA-73772;Reactome: R-HSA-167246;Reactome: R-HSA-69656;Reactome: R-HSA-75953;Reactome: R-HSA-427413;Reactome: R-HSA-69202;Reactome: R-HSA-73779;Reactome: R-HSA-6782135;Reactome: R-HSA-8939236;Reactome: R-HSA-167160;Reactome: R-HSA-75955;Reactome: R-HSA-76042;Reactome: R-HSA-112382;Reactome: R-HSA-72086;Reactome: R-HSA-73776;Reactome: R-HSA-167161;Reactome: R-HSA-6781823;Reactome: R-HSA-167162;Reactome: R-HSA-69273;Reactome: R-HSA-6782210;Reactome: R-HSA-113418;Reactome: R-HSA-6781827;Reactome: R-HSA-167158;Reactome: R-HSA-73762	"Transcription of the HIV genome";"Cyclin D associated events in G1";"RNA Polymerase I Transcription Termination";"TP53 Regulates Transcription of DNA Repair Genes";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Pol II CTD phosphorylation and interaction with CE";"RNA Polymerase II Pre-transcription Events";"Formation of Incision Complex in GG-NER";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Polymerase I Promoter Escape";"Tat-mediated elongation of the HIV-1 transcript";"Cyclin A:Cdk2-associated events at S phase entry";"RNA Polymerase II Transcription Initiation";"NoRC negatively regulates rRNA expression";"Cyclin E associated events during G1/S transition";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Dual incision in TC-NER";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"RNA Polymerase II Transcription Elongation";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Formation of RNA Pol II elongation complex";"mRNA Capping";"RNA Polymerase II Promoter Escape";"HIV Transcription Initiation";"Formation of TC-NER Pre-Incision Complex";"RNA Polymerase II HIV Promoter Escape";"Cyclin A/B1/B2 associated events during G2/M transition";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Formation of the Early Elongation Complex";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Formation of the HIV-1 Early Elongation Complex";"RNA Polymerase I Transcription Initiation"
XP_046434497.1	2	Reactome: R-HSA-430039;MetaCyc: PWY-6938	"mRNA decay by 5' to 3' exoribonuclease";"NADH repair"
XP_046428820.1	2	Reactome: R-HSA-5658442;Reactome: R-HSA-6802953	"Regulation of RAS by GAPs";"RAS signaling downstream of NF1 loss-of-function variants"
XP_046411095.1	1	Reactome: R-HSA-1474151	"Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation"
XP_046413670.1	6	MetaCyc: PWY-6733;Reactome: R-HSA-9640463;KEGG: 00073+1.2.1.84;MetaCyc: PWY-7656;MetaCyc: PWY-5884;MetaCyc: PWY-7782	"Sporopollenin precursors biosynthesis";"Wax biosynthesis";"Cutin, suberine and wax biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Wax esters biosynthesis I";"Plasmalogen biosynthesis"
XP_046416771.1	13	Reactome: R-HSA-72764;Reactome: R-HSA-156902;Reactome: R-HSA-975956;Reactome: R-HSA-6791226;Reactome: R-HSA-975957;Reactome: R-HSA-1799339;Reactome: R-HSA-72706;Reactome: R-HSA-2408557;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-192823;Reactome: R-HSA-9633012;Reactome: R-HSA-72689	"Eukaryotic Translation Termination";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Selenocysteine synthesis";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Viral mRNA Translation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Formation of a pool of free 40S subunits"
XP_046420091.1	16	Reactome: R-HSA-975956;Reactome: R-HSA-72702;Reactome: R-HSA-6791226;Reactome: R-HSA-72706;Reactome: R-HSA-2408557;Reactome: R-HSA-9633012;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-156902;Reactome: R-HSA-72649;Reactome: R-HSA-72764;Reactome: R-HSA-975957;Reactome: R-HSA-72695;Reactome: R-HSA-1799339;Reactome: R-HSA-72689;Reactome: R-HSA-192823	"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Ribosomal scanning and start codon recognition";"Major pathway of rRNA processing in the nucleolus and cytosol";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Selenocysteine synthesis";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Peptide chain elongation";"Translation initiation complex formation";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Formation of the ternary complex, and subsequently, the 43S complex";"SRP-dependent cotranslational protein targeting to membrane";"Formation of a pool of free 40S subunits";"Viral mRNA Translation"
XP_046432247.1	3	KEGG: 00230+4.6.1.2;Reactome: R-HSA-445355;Reactome: R-HSA-392154	"Purine metabolism";"Smooth Muscle Contraction";"Nitric oxide stimulates guanylate cyclase"
XP_046410014.1	1	Reactome: R-HSA-2022928	"HS-GAG biosynthesis"
XP_046421761.1	7	KEGG: 00270+2.5.1.22;KEGG: 00480+2.5.1.22;Reactome: R-HSA-351202;KEGG: 00330+2.5.1.16;KEGG: 00330+2.5.1.22;KEGG: 00270+2.5.1.16;KEGG: 00480+2.5.1.16	"Cysteine and methionine metabolism";"Glutathione metabolism";"Metabolism of polyamines";"Arginine and proline metabolism";"Arginine and proline metabolism";"Cysteine and methionine metabolism";"Glutathione metabolism"
XP_046410729.1	4	Reactome: R-HSA-5576892;Reactome: R-HSA-419037;Reactome: R-HSA-5576893;Reactome: R-HSA-112308	"Phase 0 - rapid depolarisation";"NCAM1 interactions";"Phase 2 - plateau phase";"Presynaptic depolarization and calcium channel opening"
XP_046429421.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046418261.1	29	Reactome: R-HSA-6803207;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;Reactome: R-HSA-5693565;Reactome: R-HSA-3371453;KEGG: 04926+2.7.11.1;Reactome: R-HSA-69473;Reactome: R-HSA-5693571;Reactome: R-HSA-6804756;KEGG: 05163+2.7.11.1;Reactome: R-HSA-69541;Reactome: R-HSA-6804760;Reactome: R-HSA-6796648;Reactome: R-HSA-5693616;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;Reactome: R-HSA-5693568;KEGG: 05165+2.7.11.1;Reactome: R-HSA-5693607;Reactome: R-HSA-912446;Reactome: R-HSA-5693548;Reactome: R-HSA-5685942;Reactome: R-HSA-6804757;Reactome: R-HSA-2559586;Reactome: R-HSA-349425;Reactome: R-HSA-5693579;Reactome: R-HSA-6803204;Reactome: R-HSA-5693554;Reactome: R-HSA-5685938	"TP53 Regulates Transcription of Caspase Activators and Caspases";"Human immunodeficiency virus 1 infection";"Thermogenesis";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Regulation of HSF1-mediated heat shock response";"Relaxin signaling pathway";"G2/M DNA damage checkpoint";"Nonhomologous End-Joining (NHEJ)";"Regulation of TP53 Activity through Phosphorylation";"Human cytomegalovirus infection";"Stabilization of p53";"Regulation of TP53 Activity through Methylation";"TP53 Regulates Transcription of DNA Repair Genes";"Presynaptic phase of homologous DNA pairing and strand exchange";"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Resolution of D-loop Structures through Holliday Junction Intermediates";"Human papillomavirus infection";"Processing of DNA double-strand break ends";"Meiotic recombination";"Sensing of DNA Double Strand Breaks";"HDR through Homologous Recombination (HRR)";"Regulation of TP53 Degradation";"DNA Damage/Telomere Stress Induced Senescence";"Autodegradation of the E3 ubiquitin ligase COP1";"Homologous DNA Pairing and Strand Exchange";"TP53 Regulates Transcription of Genes Involved in Cytochrome C Release";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"HDR through Single Strand Annealing (SSA)"
XP_046413061.1	2	Reactome: R-HSA-389661;Reactome: R-HSA-6783984	"Glyoxylate metabolism and glycine degradation";"Glycine degradation"
XP_046423918.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046432893.1	2	Reactome: R-HSA-6783310;Reactome: R-HSA-5693568	"Fanconi Anemia Pathway";"Resolution of D-loop Structures through Holliday Junction Intermediates"
XP_046420257.1	15	Reactome: R-HSA-3769402;Reactome: R-HSA-5358747;Reactome: R-HSA-111465;Reactome: R-HSA-5339716;Reactome: R-HSA-4641262;Reactome: R-HSA-5467340;Reactome: R-HSA-5358752;Reactome: R-HSA-195253;Reactome: R-HSA-5358751;Reactome: R-HSA-5467333;Reactome: R-HSA-5467337;Reactome: R-HSA-5467348;Reactome: R-HSA-196299;Reactome: R-HSA-5358749;Reactome: R-HSA-5689896	"Deactivation of the beta-catenin transactivating complex";"S33 mutants of beta-catenin aren't phosphorylated";"Apoptotic cleavage of cellular proteins";"Misspliced GSK3beta mutants stabilize beta-catenin";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"AXIN missense mutants destabilize the destruction complex";"T41 mutants of beta-catenin aren't phosphorylated";"Degradation of beta-catenin by the destruction complex";"S45 mutants of beta-catenin aren't phosphorylated";"APC truncation mutants are not K63 polyubiquitinated";"APC truncation mutants have impaired AXIN binding";"Truncations of AMER1 destabilize the destruction complex";"Beta-catenin phosphorylation cascade";"S37 mutants of beta-catenin aren't phosphorylated";"Ovarian tumor domain proteases"
XP_046435700.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046415787.1	2	KEGG: 00970+6.1.1.20;Reactome: R-HSA-379726	"Aminoacyl-tRNA biosynthesis";"Mitochondrial tRNA aminoacylation"
XP_046421026.1	6	MetaCyc: PWY-5884;MetaCyc: PWY-7782;Reactome: R-HSA-9640463;MetaCyc: PWY-6733;KEGG: 00073+1.2.1.84;MetaCyc: PWY-7656	"Wax esters biosynthesis I";"Plasmalogen biosynthesis";"Wax biosynthesis";"Sporopollenin precursors biosynthesis";"Cutin, suberine and wax biosynthesis";"Spodoptera littoralis pheromone biosynthesis"
XP_046417075.1	4	KEGG: 00270+4.1.1.50;MetaCyc: PWY-6834;Reactome: R-HSA-351202;KEGG: 00330+4.1.1.50	"Cysteine and methionine metabolism";"Spermidine biosynthesis III";"Metabolism of polyamines";"Arginine and proline metabolism"
XP_046430935.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_046421349.1	1	Reactome: R-HSA-9037629	"Lewis blood group biosynthesis"
XP_046417190.1	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
XP_046435851.1	3	KEGG: 00240+1.3.5.2;Reactome: R-HSA-500753;MetaCyc: PWY-5686	"Pyrimidine metabolism";"Pyrimidine biosynthesis";"UMP biosynthesis I"
XP_046415960.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046419338.1	2	Reactome: R-HSA-5610787;Reactome: R-HSA-5620924	"Hedgehog 'off' state";"Intraflagellar transport"
XP_046414628.1	9	Reactome: R-HSA-110314;Reactome: R-HSA-6781823;Reactome: R-HSA-8951664;Reactome: R-HSA-5696394;Reactome: R-HSA-6782210;Reactome: R-HSA-6781827;Reactome: R-HSA-5696400;Reactome: R-HSA-6782135;Reactome: R-HSA-5696395	"Recognition of DNA damage by PCNA-containing replication complex";"Formation of TC-NER Pre-Incision Complex";"Neddylation";"DNA Damage Recognition in GG-NER";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Dual Incision in GG-NER";"Dual incision in TC-NER";"Formation of Incision Complex in GG-NER"
XP_046428693.1	22	MetaCyc: PWY-6598;MetaCyc: PWY-7602;MetaCyc: PWY-7036;KEGG: 00062+4.2.1.134;MetaCyc: PWY-7601;MetaCyc: PWY-7053;MetaCyc: PWY-5353;MetaCyc: PWY-6958;MetaCyc: PWY-7728;MetaCyc: PWY-7606;MetaCyc: PWY-7592;Reactome: R-HSA-75876;MetaCyc: PWY-7726;MetaCyc: PWY-7724;MetaCyc: PWY-7035;MetaCyc: PWY-8041;MetaCyc: PWY-5080;MetaCyc: PWY-7725;MetaCyc: PWY-7619;MetaCyc: PWY-7049;MetaCyc: PWY-6433;MetaCyc: PWY-7727	"Sciadonate biosynthesis";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis II";"Fatty acid elongation";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Docosahexaenoate biosynthesis I (lower eukaryotes)";"Arachidonate biosynthesis I (6-desaturase, lower eukaryotes)";"Icosapentaenoate biosynthesis I (lower eukaryotes)";"(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Arachidonate biosynthesis III (6-desaturase, mammals)";"Synthesis of very long-chain fatty acyl-CoAs";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"(9Z)-tricosene biosynthesis";"Ultra-long-chain fatty acid biosynthesis";"Very long chain fatty acid biosynthesis I";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Juniperonate biosynthesis";"Icosapentaenoate biosynthesis II (6-desaturase, mammals)";"Hydroxylated fatty acid biosynthesis (plants)";"Docosahexaenoate biosynthesis IV (4-desaturase, mammals)"
XP_046413275.1	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276	"Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination"
XP_046419655.1	2	Reactome: R-HSA-2132295;Reactome: R-HSA-877300	"MHC class II antigen presentation";"Interferon gamma signaling"
XP_046416770.1	13	Reactome: R-HSA-6791226;Reactome: R-HSA-975957;Reactome: R-HSA-72764;Reactome: R-HSA-975956;Reactome: R-HSA-156902;Reactome: R-HSA-192823;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-72689;Reactome: R-HSA-9633012;Reactome: R-HSA-1799339;Reactome: R-HSA-2408557;Reactome: R-HSA-72706	"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Peptide chain elongation";"Viral mRNA Translation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Formation of a pool of free 40S subunits";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"SRP-dependent cotranslational protein targeting to membrane";"Selenocysteine synthesis";"GTP hydrolysis and joining of the 60S ribosomal subunit"
XP_046430201.1	2	Reactome: R-HSA-3928665;Reactome: R-HSA-2682334	"EPH-ephrin mediated repulsion of cells";"EPH-Ephrin signaling"
XP_046425312.1	1	Reactome: R-HSA-216083	"Integrin cell surface interactions"
XP_046420199.1	1	Reactome: R-HSA-159236	"Transport of Mature mRNA derived from an Intron-Containing Transcript"
XP_046434924.1	2	Reactome: R-HSA-8964038;Reactome: R-HSA-6798695	"LDL clearance";"Neutrophil degranulation"
XP_046412127.1	2	Reactome: R-HSA-8873719;Reactome: R-HSA-6803205	"RAB geranylgeranylation";"TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain"
XP_046431933.1	5	MetaCyc: PWY-6902;MetaCyc: PWY-6855;MetaCyc: PWY-7822;KEGG: 00520+3.2.1.14;Reactome: R-HSA-189085	"Chitin degradation II (Vibrio)";"Chitin degradation I (archaea)";"Chitin degradation III (Serratia)";"Amino sugar and nucleotide sugar metabolism";"Digestion of dietary carbohydrate"
XP_046410445.1	6	Reactome: R-HSA-2426168;MetaCyc: PWY-922;KEGG: 00900+4.1.1.33;Reactome: R-HSA-446199;Reactome: R-HSA-191273;MetaCyc: PWY-7391	"Activation of gene expression by SREBF (SREBP)";"Mevalonate pathway I";"Terpenoid backbone biosynthesis";"Synthesis of Dolichyl-phosphate";"Cholesterol biosynthesis";"Isoprene biosynthesis II (engineered)"
XP_046425732.1	1	Reactome: R-HSA-1660662	"Glycosphingolipid metabolism"
XP_046427865.1	3	KEGG: 00730+3.1.3.1;KEGG: 00790+3.1.3.1;MetaCyc: PWY-5491	"Thiamine metabolism";"Folate biosynthesis";"Diethylphosphate degradation"
XP_046427157.1	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
XP_046418870.1	2	Reactome: R-HSA-9603798;Reactome: R-HSA-1369062	"Class I peroxisomal membrane protein import";"ABC transporters in lipid homeostasis"
XP_046426361.1	8	MetaCyc: PWY-7179-1;Reactome: R-HSA-5683826;MetaCyc: PWY-6609;KEGG: 00230+3.5.4.4;MetaCyc: PWY-6611;Reactome: R-HSA-6798695;Reactome: R-HSA-74217;MetaCyc: PWY-7179	"Purine deoxyribonucleosides degradation II";"Surfactant metabolism";"Adenine and adenosine salvage III";"Purine metabolism";"Adenine and adenosine salvage V";"Neutrophil degranulation";"Purine salvage";"Purine deoxyribonucleosides degradation I"
XP_046423267.1	17	Reactome: R-HSA-2426168;MetaCyc: PWY-5743;KEGG: 00720+6.4.1.2;MetaCyc: PWY-6679;Reactome: R-HSA-200425;KEGG: 00640+6.4.1.2;MetaCyc: PWY-5966-1;Reactome: R-HSA-196780;MetaCyc: PWY-4381;MetaCyc: PWY-5789;Reactome: R-HSA-3371599;KEGG: 00061+6.4.1.2;MetaCyc: PWY-5744;MetaCyc: PWY-6722;KEGG: 00254+6.4.1.2;KEGG: 00620+6.4.1.2;Reactome: R-HSA-163765	"Activation of gene expression by SREBF (SREBP)";"3-hydroxypropanoate cycle";"Carbon fixation pathways in prokaryotes";"Jadomycin biosynthesis";"Carnitine metabolism";"Propanoate metabolism";"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)";"Biotin transport and metabolism";"Fatty acid biosynthesis initiation (bacteria and plants)";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Defective HLCS causes multiple carboxylase deficiency";"Fatty acid biosynthesis";"Glyoxylate assimilation";"Candicidin biosynthesis";"Aflatoxin biosynthesis";"Pyruvate metabolism";"ChREBP activates metabolic gene expression"
XP_046420053.1	1	Reactome: R-HSA-3214842	"HDMs demethylate histones"
XP_046434431.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_046422545.1	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
XP_046427575.1	1	Reactome: R-HSA-5620922	"BBSome-mediated cargo-targeting to cilium"
XP_046421826.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_046418858.1	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
XP_046431396.1	27	Reactome: R-HSA-3371453;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;Reactome: R-HSA-5358747;Reactome: R-HSA-8939902;Reactome: R-HSA-5467340;Reactome: R-HSA-198323;Reactome: R-HSA-5358751;KEGG: 04926+2.7.11.1;Reactome: R-HSA-195253;Reactome: R-HSA-5358752;KEGG: 05163+2.7.11.1;Reactome: R-HSA-5467337;Reactome: R-HSA-5467348;Reactome: R-HSA-5674400;KEGG: 05165+2.7.11.1;Reactome: R-HSA-5358749;Reactome: R-HSA-75815;Reactome: R-HSA-399956;Reactome: R-HSA-196299;Reactome: R-HSA-5339716;Reactome: R-HSA-4641262;Reactome: R-HSA-5610785;Reactome: R-HSA-5250924;Reactome: R-HSA-5610783	"Regulation of HSF1-mediated heat shock response";"Human immunodeficiency virus 1 infection";"Thermogenesis";"mTOR signaling pathway";"PI3K-Akt signaling pathway";"S33 mutants of beta-catenin aren't phosphorylated";"Regulation of RUNX2 expression and activity";"AXIN missense mutants destabilize the destruction complex";"AKT phosphorylates targets in the cytosol";"S45 mutants of beta-catenin aren't phosphorylated";"Relaxin signaling pathway";"Degradation of beta-catenin by the destruction complex";"T41 mutants of beta-catenin aren't phosphorylated";"Human cytomegalovirus infection";"APC truncation mutants have impaired AXIN binding";"Truncations of AMER1 destabilize the destruction complex";"Constitutive Signaling by AKT1 E17K in Cancer";"Human papillomavirus infection";"S37 mutants of beta-catenin aren't phosphorylated";"Ubiquitin-dependent degradation of Cyclin D";"CRMPs in Sema3A signaling";"Beta-catenin phosphorylation cascade";"Misspliced GSK3beta mutants stabilize beta-catenin";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"GLI3 is processed to GLI3R by the proteasome";"B-WICH complex positively regulates rRNA expression";"Degradation of GLI2 by the proteasome"
XP_046433181.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046429426.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046429312.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_046434492.1	2	Reactome: R-HSA-6811434;Reactome: R-HSA-6807878	"COPI-dependent Golgi-to-ER retrograde traffic";"COPI-mediated anterograde transport"
XP_046412742.1	1	Reactome: R-HSA-1799339	"SRP-dependent cotranslational protein targeting to membrane"
XP_046411072.1	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
XP_046433087.1	3	Reactome: R-HSA-881907;Reactome: R-HSA-416476;Reactome: R-HSA-375276	"Gastrin-CREB signalling pathway via PKC and MAPK";"G alpha (q) signalling events";"Peptide ligand-binding receptors"
XP_046436448.1	5	Reactome: R-HSA-2871796;KEGG: 04150+2.7.11.24;Reactome: R-HSA-450321;Reactome: R-HSA-450341;Reactome: R-HSA-2559580	"FCERI mediated MAPK activation";"mTOR signaling pathway";"JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1";"Activation of the AP-1 family of transcription factors";"Oxidative Stress Induced Senescence"
XP_046418381.1	2	MetaCyc: PWY-6749;KEGG: 00520+5.4.2.10	"CMP-legionaminate biosynthesis I";"Amino sugar and nucleotide sugar metabolism"
XP_046428302.1	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
XP_046430520.1	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
XP_046428281.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_046436407.1	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
XP_046413160.1	2	Reactome: R-HSA-72165;Reactome: R-HSA-72163	"mRNA Splicing - Minor Pathway";"mRNA Splicing - Major Pathway"
XP_046432984.1	5	KEGG: 00230+6.3.5.3;MetaCyc: PWY-6277;Reactome: R-HSA-73817;MetaCyc: PWY-6122;MetaCyc: PWY-6121	"Purine metabolism";"Superpathway of 5-aminoimidazole ribonucleotide biosynthesis";"Purine ribonucleoside monophosphate biosynthesis";"5-aminoimidazole ribonucleotide biosynthesis II";"5-aminoimidazole ribonucleotide biosynthesis I"
XP_046414848.1	1	Reactome: R-HSA-212300	"PRC2 methylates histones and DNA"
XP_046428666.1	4	KEGG: 00592+3.1.1.32;MetaCyc: PWY-8051;MetaCyc: PWY-6803;KEGG: 00564+3.1.1.32	"alpha-Linolenic acid metabolism";"Anandamide biosynthesis I";"Phosphatidylcholine acyl editing";"Glycerophospholipid metabolism"
XP_046434735.1	1	Reactome: R-HSA-191859	"snRNP Assembly"
XP_046420813.1	5	Reactome: R-HSA-380994;Reactome: R-HSA-9648895;Reactome: R-HSA-9633012;KEGG: 00250+6.3.5.4;Reactome: R-HSA-8963693	"ATF4 activates genes in response to endoplasmic reticulum stress";"Response of EIF2AK1 (HRI) to heme deficiency";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Alanine, aspartate and glutamate metabolism";"Aspartate and asparagine metabolism"
XP_046427011.1	1	KEGG: 00230+4.6.1.2	"Purine metabolism"
XP_046417258.1	1	KEGG: 00760+2.3.1.286	"Nicotinate and nicotinamide metabolism"
XP_046420733.1	42	Reactome: R-HSA-1912408;Reactome: R-HSA-2299718;Reactome: R-HSA-110329;Reactome: R-HSA-9610379;Reactome: R-HSA-73772;Reactome: R-HSA-8936459;Reactome: R-HSA-5693565;Reactome: R-HSA-171306;Reactome: R-HSA-4551638;Reactome: R-HSA-212300;Reactome: R-HSA-3214841;Reactome: R-HSA-3214842;Reactome: R-HSA-9616222;Reactome: R-HSA-3214815;Reactome: R-HSA-427389;Reactome: R-HSA-5250924;Reactome: R-HSA-8939236;Reactome: R-HSA-3214847;Reactome: R-HSA-606279;Reactome: R-HSA-110331;Reactome: R-HSA-2559580;Reactome: R-HSA-427413;Reactome: R-HSA-5693607;Reactome: R-HSA-3214858;Reactome: R-HSA-110328;Reactome: R-HSA-9609690;Reactome: R-HSA-2559582;Reactome: R-HSA-69473;Reactome: R-HSA-9018519;Reactome: R-HSA-5693571;Reactome: R-HSA-5617472;Reactome: R-HSA-73728;Reactome: R-HSA-5625886;Reactome: R-HSA-5578749;Reactome: R-HSA-977225;Reactome: R-HSA-1221632;Reactome: R-HSA-201722;Reactome: R-HSA-2559586;Reactome: R-HSA-912446;Reactome: R-HSA-110330;Reactome: R-HSA-5334118;Reactome: R-HSA-427359	"Pre-NOTCH Transcription and Translation";"Condensation of Prophase Chromosomes";"Cleavage of the damaged pyrimidine";"HCMV Late Events";"RNA Polymerase I Promoter Escape";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Packaging Of Telomere Ends";"SUMOylation of chromatin organization proteins";"PRC2 methylates histones and DNA";"PKMTs methylate histone lysines";"HDMs demethylate histones";"Transcriptional regulation of granulopoiesis";"HDACs deacetylate histones";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"B-WICH complex positively regulates rRNA expression";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"HATs acetylate histones";"Deposition of new CENPA-containing nucleosomes at the centromere";"Cleavage of the damaged purine";"Oxidative Stress Induced Senescence";"NoRC negatively regulates rRNA expression";"Processing of DNA double-strand break ends";"RMTs methylate histone arginines";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"HCMV Early Events";"Senescence-Associated Secretory Phenotype (SASP)";"G2/M DNA damage checkpoint";"Estrogen-dependent gene expression";"Nonhomologous End-Joining (NHEJ)";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"RNA Polymerase I Promoter Opening";"Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3";"Transcriptional regulation by small RNAs";"Amyloid fiber formation";"Meiotic synapsis";"Formation of the beta-catenin:TCF transactivating complex";"DNA Damage/Telomere Stress Induced Senescence";"Meiotic recombination";"Recognition and association of DNA glycosylase with site containing an affected purine";"DNA methylation";"SIRT1 negatively regulates rRNA expression"
XP_046431161.1	1	Reactome: R-HSA-156581	"Methylation"
XP_046431221.1	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_046425120.1	10	KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;Reactome: R-HSA-437239;Reactome: R-HSA-442742;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;Reactome: R-HSA-444257	"Thermogenesis";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Recycling pathway of L1";"CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling";"Human cytomegalovirus infection";"Relaxin signaling pathway";"mTOR signaling pathway";"PI3K-Akt signaling pathway";"RSK activation"
XP_046434589.1	22	Reactome: R-HSA-5673000;Reactome: R-HSA-2500257;Reactome: R-HSA-389513;Reactome: R-HSA-5358747;Reactome: R-HSA-5467340;Reactome: R-HSA-6811558;Reactome: R-HSA-2467813;Reactome: R-HSA-195253;Reactome: R-HSA-5358752;Reactome: R-HSA-5358751;Reactome: R-HSA-141444;Reactome: R-HSA-9648025;Reactome: R-HSA-5467348;Reactome: R-HSA-5663220;Reactome: R-HSA-5467337;Reactome: R-HSA-5358749;Reactome: R-HSA-196299;Reactome: R-HSA-4641262;Reactome: R-HSA-5339716;Reactome: R-HSA-5675221;Reactome: R-HSA-432142;Reactome: R-HSA-68877	"RAF activation";"Resolution of Sister Chromatid Cohesion";"CTLA4 inhibitory signaling";"S33 mutants of beta-catenin aren't phosphorylated";"AXIN missense mutants destabilize the destruction complex";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"Separation of Sister Chromatids";"Degradation of beta-catenin by the destruction complex";"T41 mutants of beta-catenin aren't phosphorylated";"S45 mutants of beta-catenin aren't phosphorylated";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"EML4 and NUDC in mitotic spindle formation";"Truncations of AMER1 destabilize the destruction complex";"RHO GTPases Activate Formins";"APC truncation mutants have impaired AXIN binding";"S37 mutants of beta-catenin aren't phosphorylated";"Beta-catenin phosphorylation cascade";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"Misspliced GSK3beta mutants stabilize beta-catenin";"Negative regulation of MAPK pathway";"Platelet sensitization by LDL";"Mitotic Prometaphase"
XP_046418143.1	1	Reactome: R-HSA-1445148	"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
XP_046417218.1	24	Reactome: R-HSA-3371497;Reactome: R-HSA-437239;Reactome: R-HSA-5663220;Reactome: R-HSA-9646399;Reactome: R-HSA-190861;Reactome: R-HSA-6811436;Reactome: R-HSA-8852276;Reactome: R-HSA-68877;Reactome: R-HSA-190840;Reactome: R-HSA-9609736;Reactome: R-HSA-8955332;Reactome: R-HSA-2132295;Reactome: R-HSA-5617833;Reactome: R-HSA-6807878;Reactome: R-HSA-5626467;Reactome: R-HSA-2500257;Reactome: R-HSA-983189;Reactome: R-HSA-1445148;Reactome: R-HSA-9619483;Reactome: R-HSA-2467813;Reactome: R-HSA-9609690;Reactome: R-HSA-380320;Reactome: R-HSA-9648025;Reactome: R-HSA-6811434	"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Recycling pathway of L1";"RHO GTPases Activate Formins";"Aggrephagy";"Gap junction assembly";"COPI-independent Golgi-to-ER retrograde traffic";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Mitotic Prometaphase";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Assembly and cell surface presentation of NMDA receptors";"Carboxyterminal post-translational modifications of tubulin";"MHC class II antigen presentation";"Cilium Assembly";"COPI-mediated anterograde transport";"RHO GTPases activate IQGAPs";"Resolution of Sister Chromatid Cohesion";"Kinesins";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Activation of AMPK downstream of NMDARs";"Separation of Sister Chromatids";"HCMV Early Events";"Recruitment of NuMA to mitotic centrosomes";"EML4 and NUDC in mitotic spindle formation";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_046431460.1	2	Reactome: R-HSA-373080;Reactome: R-HSA-3238698	"Class B/2 (Secretin family receptors)";"WNT ligand biogenesis and trafficking"
XP_046413625.1	2	Reactome: R-HSA-2029482;Reactome: R-HSA-5663213	"Regulation of actin dynamics for phagocytic cup formation";"RHO GTPases Activate WASPs and WAVEs"
XP_046418933.1	1	Reactome: R-HSA-5693571	"Nonhomologous End-Joining (NHEJ)"
XP_046425721.1	2	Reactome: R-HSA-977225;Reactome: R-HSA-8854214	"Amyloid fiber formation";"TBC/RABGAPs"
XP_046423595.1	6	KEGG: 00562+3.1.3.56;KEGG: 04070+3.1.3.56;MetaCyc: PWY-6363;MetaCyc: PWY-6364;MetaCyc: PWY-6362;Reactome: R-HSA-1855183	"Inositol phosphate metabolism";"Phosphatidylinositol signaling system";"D-myo-inositol (1,4,5)-trisphosphate degradation";"D-myo-inositol (1,3,4)-trisphosphate biosynthesis";"1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)";"Synthesis of IP2, IP, and Ins in the cytosol"
XP_046421605.1	12	Reactome: R-HSA-2979096;Reactome: R-HSA-9017802;Reactome: R-HSA-193692;Reactome: R-HSA-9013507;Reactome: R-HSA-1251985;Reactome: R-HSA-9013700;Reactome: R-HSA-2894862;Reactome: R-HSA-2122948;Reactome: R-HSA-977225;Reactome: R-HSA-205043;Reactome: R-HSA-3928665;Reactome: R-HSA-2644606	"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Noncanonical activation of NOTCH3";"Regulated proteolysis of p75NTR";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Nuclear signaling by ERBB4";"NOTCH4 Activation and Transmission of Signal to the Nucleus";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Activated NOTCH1 Transmits Signal to the Nucleus";"Amyloid fiber formation";"NRIF signals cell death from the nucleus";"EPH-ephrin mediated repulsion of cells";"Constitutive Signaling by NOTCH1 PEST Domain Mutants"
XP_046420871.1	2	MetaCyc: PWY-6019;KEGG: 00240+4.2.1.70	"Pseudouridine degradation";"Pyrimidine metabolism"
XP_046415879.1	2	Reactome: R-HSA-1660662;Reactome: R-HSA-390471	"Glycosphingolipid metabolism";"Association of TriC/CCT with target proteins during biosynthesis"
XP_046421883.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046410413.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046425340.1	1	Reactome: R-HSA-216083	"Integrin cell surface interactions"
XP_046419062.1	1	Reactome: R-HSA-5658442	"Regulation of RAS by GAPs"
XP_046436704.1	3	KEGG: 00330+1.14.11.2;Reactome: R-HSA-1650814;MetaCyc: PWY-7894	"Arginine and proline metabolism";"Collagen biosynthesis and modifying enzymes";"Procollagen hydroxylation and glycosylation"
XP_046427827.1	1	Reactome: R-HSA-429958	"mRNA decay by 3' to 5' exoribonuclease"
XP_046418321.1	3	Reactome: R-HSA-193648;Reactome: R-HSA-416482;Reactome: R-HSA-194840	"NRAGE signals death through JNK";"G alpha (12/13) signalling events";"Rho GTPase cycle"
XP_046424144.1	10	MetaCyc: PWY-1042;KEGG: 00051+5.3.1.1;MetaCyc: PWY-5484;KEGG: 00010+5.3.1.1;MetaCyc: PWY-7003;Reactome: R-HSA-70171;Reactome: R-HSA-70263;KEGG: 00562+5.3.1.1;KEGG: 00710+5.3.1.1;MetaCyc: PWY-6142	"Glycolysis IV (plant cytosol)";"Fructose and mannose metabolism";"Glycolysis II (from fructose 6-phosphate)";"Glycolysis / Gluconeogenesis";"Glycerol degradation to butanol";"Glycolysis";"Gluconeogenesis";"Inositol phosphate metabolism";"Carbon fixation in photosynthetic organisms";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)"
XP_046413425.1	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
XP_046425431.1	2	Reactome: R-HSA-375280;Reactome: R-HSA-416476	"Amine ligand-binding receptors";"G alpha (q) signalling events"
XP_046429503.1	1	Reactome: R-HSA-419771	"Opsins"
XP_046435354.1	1	Reactome: R-HSA-611105	"Respiratory electron transport"
XP_046416272.1	1	Reactome: R-HSA-5576886	"Phase 4 - resting membrane potential"
XP_046427484.1	2	Reactome: R-HSA-5576893;Reactome: R-HSA-5576892	"Phase 2 - plateau phase";"Phase 0 - rapid depolarisation"
XP_046424405.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046409970.1	6	Reactome: R-HSA-156827;Reactome: R-HSA-72689;Reactome: R-HSA-72649;Reactome: R-HSA-72706;Reactome: R-HSA-72702;Reactome: R-HSA-72695	"L13a-mediated translational silencing of Ceruloplasmin expression";"Formation of a pool of free 40S subunits";"Translation initiation complex formation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Ribosomal scanning and start codon recognition";"Formation of the ternary complex, and subsequently, the 43S complex"
XP_046410985.1	6	Reactome: R-HSA-8874081;Reactome: R-HSA-3000171;Reactome: R-HSA-1650814;Reactome: R-HSA-2022090;Reactome: R-HSA-8948216;Reactome: R-HSA-1442490	"MET activates PTK2 signaling";"Non-integrin membrane-ECM interactions";"Collagen biosynthesis and modifying enzymes";"Assembly of collagen fibrils and other multimeric structures";"Collagen chain trimerization";"Collagen degradation"
XP_046425678.1	4	Reactome: R-HSA-8951664;Reactome: R-HSA-6781823;Reactome: R-HSA-8856825;Reactome: R-HSA-5696394	"Neddylation";"Formation of TC-NER Pre-Incision Complex";"Cargo recognition for clathrin-mediated endocytosis";"DNA Damage Recognition in GG-NER"
XP_046419529.1	1	Reactome: R-HSA-975957	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
XP_046435290.1	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
XP_046418241.1	7	Reactome: R-HSA-73980;Reactome: R-HSA-73780;Reactome: R-HSA-76071;Reactome: R-HSA-1834949;Reactome: R-HSA-749476;Reactome: R-HSA-76066;Reactome: R-HSA-76061	"RNA Polymerase III Transcription Termination";"RNA Polymerase III Chain Elongation";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Transcription Initiation From Type 1 Promoter"
XP_046426503.1	7	KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1	"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Thermogenesis";"Human cytomegalovirus infection";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Relaxin signaling pathway"
XP_046428309.1	2	Reactome: R-HSA-5339700;Reactome: R-HSA-4641265	"TCF7L2 mutants don't bind CTBP";"Repression of WNT target genes"
XP_046426578.1	2	Reactome: R-HSA-5576894;Reactome: R-HSA-1296072	"Phase 1 - inactivation of fast Na+ channels";"Voltage gated Potassium channels"
XP_046431337.1	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
XP_046435300.1	3	KEGG: 00561+3.1.1.23;Reactome: R-HSA-426048;MetaCyc: PWY-7420	"Glycerolipid metabolism";"Arachidonate production from DAG";"Monoacylglycerol metabolism (yeast)"
XP_046416365.1	2	Reactome: R-HSA-5576892;Reactome: R-HSA-5576893	"Phase 0 - rapid depolarisation";"Phase 2 - plateau phase"
XP_046427162.1	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
XP_046433626.1	1	MetaCyc: PWY-7799	"Arg/N-end rule pathway (eukaryotic)"
XP_046412173.1	4	Reactome: R-HSA-73614;KEGG: 00983+2.7.1.48;MetaCyc: PWY-7193;KEGG: 00240+2.7.1.48	"Pyrimidine salvage";"Drug metabolism - other enzymes";"Pyrimidine ribonucleosides salvage I";"Pyrimidine metabolism"
XP_046426933.1	6	MetaCyc: PWY-7442;Reactome: R-HSA-74259;MetaCyc: PWY-6608;KEGG: 00230+3.5.4.3;MetaCyc: PWY-6606;MetaCyc: PWY-5497	"Drosopterin and aurodrosopterin biosynthesis";"Purine catabolism";"Guanosine nucleotides degradation III";"Purine metabolism";"Guanosine nucleotides degradation II";"Purine nucleobases degradation II (anaerobic)"
XP_046425518.1	2	Reactome: R-HSA-380270;Reactome: R-HSA-380320	"Recruitment of mitotic centrosome proteins and complexes";"Recruitment of NuMA to mitotic centrosomes"
XP_046417686.1	1	KEGG: 00970+6.1.1.3	"Aminoacyl-tRNA biosynthesis"
XP_046411467.1	2	KEGG: 00230+2.7.4.8;MetaCyc: PWY-7221	"Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis"
XP_046431394.1	27	Reactome: R-HSA-5250924;Reactome: R-HSA-5610783;Reactome: R-HSA-5610785;Reactome: R-HSA-4641262;Reactome: R-HSA-5339716;Reactome: R-HSA-196299;Reactome: R-HSA-5358749;Reactome: R-HSA-75815;Reactome: R-HSA-399956;KEGG: 05165+2.7.11.1;Reactome: R-HSA-5467348;Reactome: R-HSA-5467337;Reactome: R-HSA-5674400;KEGG: 05163+2.7.11.1;Reactome: R-HSA-5358752;Reactome: R-HSA-195253;KEGG: 04926+2.7.11.1;Reactome: R-HSA-5358751;Reactome: R-HSA-5358747;Reactome: R-HSA-8939902;Reactome: R-HSA-5467340;Reactome: R-HSA-198323;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;Reactome: R-HSA-3371453	"B-WICH complex positively regulates rRNA expression";"Degradation of GLI2 by the proteasome";"GLI3 is processed to GLI3R by the proteasome";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"Misspliced GSK3beta mutants stabilize beta-catenin";"Beta-catenin phosphorylation cascade";"S37 mutants of beta-catenin aren't phosphorylated";"Ubiquitin-dependent degradation of Cyclin D";"CRMPs in Sema3A signaling";"Human papillomavirus infection";"Truncations of AMER1 destabilize the destruction complex";"APC truncation mutants have impaired AXIN binding";"Constitutive Signaling by AKT1 E17K in Cancer";"Human cytomegalovirus infection";"T41 mutants of beta-catenin aren't phosphorylated";"Degradation of beta-catenin by the destruction complex";"Relaxin signaling pathway";"S45 mutants of beta-catenin aren't phosphorylated";"S33 mutants of beta-catenin aren't phosphorylated";"Regulation of RUNX2 expression and activity";"AXIN missense mutants destabilize the destruction complex";"AKT phosphorylates targets in the cytosol";"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Thermogenesis";"Human immunodeficiency virus 1 infection";"Regulation of HSF1-mediated heat shock response"
XP_046413431.1	11	Reactome: R-HSA-2219530;Reactome: R-HSA-6785631;Reactome: R-HSA-1227986;Reactome: R-HSA-5673001;Reactome: R-HSA-1257604;Reactome: R-HSA-8847993;Reactome: R-HSA-9664565;Reactome: R-HSA-1250196;Reactome: R-HSA-6811558;Reactome: R-HSA-8863795;Reactome: R-HSA-1963642	"Constitutive Signaling by Aberrant PI3K in Cancer";"ERBB2 Regulates Cell Motility";"Signaling by ERBB2";"RAF/MAP kinase cascade";"PIP3 activates AKT signaling";"ERBB2 Activates PTK6 Signaling";"Signaling by ERBB2 KD Mutants";"SHC1 events in ERBB2 signaling";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"Downregulation of ERBB2 signaling";"PI3K events in ERBB2 signaling"
XP_046417750.1	1	Reactome: R-HSA-201451	"Signaling by BMP"
XP_046420873.1	7	KEGG: 00480+6.3.2.2;KEGG: 00270+6.3.2.2;Reactome: R-HSA-5578999;MetaCyc: PWY-8043;MetaCyc: PWY-6840;MetaCyc: PWY-7255;Reactome: R-HSA-174403	"Glutathione metabolism";"Cysteine and methionine metabolism";"Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD)";"Ophthalmate biosynthesis";"Homoglutathione biosynthesis";"Ergothioneine biosynthesis I (bacteria)";"Glutathione synthesis and recycling"
XP_046414864.1	2	Reactome: R-HSA-114608;KEGG: 00970+6.1.1.3	"Platelet degranulation";"Aminoacyl-tRNA biosynthesis"
XP_046413097.1	2	Reactome: R-HSA-72165;Reactome: R-HSA-72163	"mRNA Splicing - Minor Pathway";"mRNA Splicing - Major Pathway"
XP_046421531.1	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
XP_046419639.1	1	Reactome: R-HSA-211897	"Cytochrome P450 - arranged by substrate type"
XP_046432133.1	3	MetaCyc: PWY-5491;KEGG: 00790+3.1.3.1;KEGG: 00730+3.1.3.1	"Diethylphosphate degradation";"Folate biosynthesis";"Thiamine metabolism"
XP_046410288.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046429435.1	1	Reactome: R-HSA-1632852	"Macroautophagy"
XP_046418463.1	2	Reactome: R-HSA-5576893;Reactome: R-HSA-5576892	"Phase 2 - plateau phase";"Phase 0 - rapid depolarisation"
XP_046430586.1	1	Reactome: R-HSA-426117	"Cation-coupled Chloride cotransporters"
XP_046432892.1	2	Reactome: R-HSA-5693568;Reactome: R-HSA-6783310	"Resolution of D-loop Structures through Holliday Junction Intermediates";"Fanconi Anemia Pathway"
XP_046436419.1	2	Reactome: R-HSA-204005;Reactome: R-HSA-8876198	"COPII-mediated vesicle transport";"RAB GEFs exchange GTP for GDP on RABs"
XP_046412071.1	1	Reactome: R-HSA-977347	"Serine biosynthesis"
XP_046425262.1	13	Reactome: R-HSA-72706;Reactome: R-HSA-2408557;Reactome: R-HSA-1799339;Reactome: R-HSA-9633012;Reactome: R-HSA-72689;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-192823;Reactome: R-HSA-156902;Reactome: R-HSA-975956;Reactome: R-HSA-72764;Reactome: R-HSA-975957;Reactome: R-HSA-6791226	"GTP hydrolysis and joining of the 60S ribosomal subunit";"Selenocysteine synthesis";"SRP-dependent cotranslational protein targeting to membrane";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Formation of a pool of free 40S subunits";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Viral mRNA Translation";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046435704.1	1	Reactome: R-HSA-1237044	"Erythrocytes take up carbon dioxide and release oxygen"
XP_046409585.1	1	Reactome: R-HSA-1362409	"Mitochondrial iron-sulfur cluster biogenesis"
XP_046419168.1	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
XP_046419496.1	3	Reactome: R-HSA-3000157;Reactome: R-HSA-3000171;Reactome: R-HSA-8874081	"Laminin interactions";"Non-integrin membrane-ECM interactions";"MET activates PTK2 signaling"
XP_046434655.1	3	Reactome: R-HSA-73856;Reactome: R-HSA-72187;Reactome: R-HSA-159236	"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing";"Transport of Mature mRNA derived from an Intron-Containing Transcript"
XP_046410067.1	3	Reactome: R-HSA-9603798;Reactome: R-HSA-9033241;Reactome: R-HSA-8866654	"Class I peroxisomal membrane protein import";"Peroxisomal protein import";"E3 ubiquitin ligases ubiquitinate target proteins"
XP_046414310.1	56	Reactome: R-HSA-9604323;Reactome: R-HSA-5362768;Reactome: R-HSA-5676590;Reactome: R-HSA-69601;Reactome: R-HSA-69017;Reactome: R-HSA-5358346;Reactome: R-HSA-382556;Reactome: R-HSA-1169091;Reactome: R-HSA-68949;Reactome: R-HSA-195253;Reactome: R-HSA-174178;Reactome: R-HSA-2871837;Reactome: R-HSA-450408;Reactome: R-HSA-5610780;Reactome: R-HSA-1236974;Reactome: R-HSA-211733;Reactome: R-HSA-4641258;Reactome: R-HSA-5632684;Reactome: R-HSA-350562;Reactome: R-HSA-9010553;Reactome: R-HSA-8941858;Reactome: R-HSA-5668541;Reactome: R-HSA-68827;Reactome: R-HSA-5689603;Reactome: R-HSA-187577;Reactome: R-HSA-180534;Reactome: R-HSA-5607764;Reactome: R-HSA-69481;Reactome: R-HSA-1234176;Reactome: R-HSA-8948751;Reactome: R-HSA-5610783;Reactome: R-HSA-8852276;Reactome: R-HSA-9020702;Reactome: R-HSA-8854050;Reactome: R-HSA-174113;Reactome: R-HSA-5687128;Reactome: R-HSA-174154;Reactome: R-HSA-8939902;Reactome: R-HSA-174184;Reactome: R-HSA-2467813;Reactome: R-HSA-5607761;Reactome: R-HSA-5658442;Reactome: R-HSA-983168;Reactome: R-HSA-180585;Reactome: R-HSA-5678895;Reactome: R-HSA-5610785;Reactome: R-HSA-8939236;Reactome: R-HSA-174084;Reactome: R-HSA-8951664;Reactome: R-HSA-5689880;Reactome: R-HSA-349425;Reactome: R-HSA-1236978;Reactome: R-HSA-202424;Reactome: R-HSA-75815;Reactome: R-HSA-4641257;Reactome: R-HSA-4608870	"Negative regulation of NOTCH4 signaling";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"NIK-->noncanonical NF-kB signaling";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"CDK-mediated phosphorylation and removal of Cdc6";"Hedgehog ligand biogenesis";"ABC-family proteins mediated transport";"Activation of NF-kappaB in B cells";"Orc1 removal from chromatin";"Degradation of beta-catenin by the destruction complex";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"FCERI mediated NF-kB activation";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Degradation of GLI1 by the proteasome";"ER-Phagosome pathway";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Degradation of DVL";"Hedgehog 'on' state";"Regulation of ornithine decarboxylase (ODC)";"Regulation of expression of SLITs and ROBOs";"Regulation of RUNX3 expression and activity";"TNFR2 non-canonical NF-kB pathway";"CDT1 association with the CDC6:ORC:origin complex";"UCH proteinases";"SCF(Skp2)-mediated degradation of p27/p21";"Vpu mediated degradation of CD4";"CLEC7A (Dectin-1) signaling";"G2/M Checkpoints";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of PTEN stability and activity";"Degradation of GLI2 by the proteasome";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Interleukin-1 signaling";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"SCF-beta-TrCP mediated degradation of Emi1";"MAPK6/MAPK4 signaling";"APC/C:Cdc20 mediated degradation of Securin";"Regulation of RUNX2 expression and activity";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Separation of Sister Chromatids";"Dectin-1 mediated noncanonical NF-kB signaling";"Regulation of RAS by GAPs";"Antigen processing: Ubiquitination & Proteasome degradation";"Vif-mediated degradation of APOBEC3G";"Defective CFTR causes cystic fibrosis";"GLI3 is processed to GLI3R by the proteasome";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Autodegradation of Cdh1 by Cdh1:APC/C";"Neddylation";"Ub-specific processing proteases";"Autodegradation of the E3 ubiquitin ligase COP1";"Cross-presentation of soluble exogenous antigens (endosomes)";"Downstream TCR signaling";"Ubiquitin-dependent degradation of Cyclin D";"Degradation of AXIN";"Asymmetric localization of PCP proteins"
XP_046435222.1	2	Reactome: R-HSA-5693568;Reactome: R-HSA-6783310	"Resolution of D-loop Structures through Holliday Junction Intermediates";"Fanconi Anemia Pathway"
XP_046412473.1	1	KEGG: 00970+6.3.5.7	"Aminoacyl-tRNA biosynthesis"
XP_046432380.1	3	Reactome: R-HSA-168928;Reactome: R-HSA-70350;Reactome: R-HSA-9639288	"DDX58/IFIH1-mediated induction of interferon-alpha/beta";"Fructose catabolism";"Amino acids regulate mTORC1"
XP_046435778.1	1	Reactome: R-HSA-390651	"Dopamine receptors"
XP_046418460.1	4	Reactome: R-HSA-76066;Reactome: R-HSA-76061;Reactome: R-HSA-76071;Reactome: R-HSA-749476	"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Abortive And Retractive Initiation"
XP_046414266.1	1	Reactome: R-HSA-198933	"Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"
XP_046416356.1	2	Reactome: R-HSA-5576893;Reactome: R-HSA-5576892	"Phase 2 - plateau phase";"Phase 0 - rapid depolarisation"
XP_046419117.1	1	Reactome: R-HSA-382556	"ABC-family proteins mediated transport"
XP_046428771.1	7	KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1	"Thermogenesis";"Human cytomegalovirus infection";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Relaxin signaling pathway";"mTOR signaling pathway";"PI3K-Akt signaling pathway"
XP_046426771.1	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
XP_046434300.1	1	Reactome: R-HSA-1855231	"Synthesis of IPs in the ER lumen"
XP_046413654.1	2	Reactome: R-HSA-8856828;Reactome: R-HSA-8856825	"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis"
XP_046433258.1	13	MetaCyc: PWY-3841;MetaCyc: PWY-2161;MetaCyc: PWY-1722;MetaCyc: PWY-5497;KEGG: 00720+6.3.4.3;KEGG: 00720+1.5.1.5+3.5.4.9;MetaCyc: PWY-2201;MetaCyc: PWY-6613;KEGG: 00670+6.3.4.3;Reactome: R-HSA-196757;MetaCyc: PWY-5030;KEGG: 00670+1.5.1.5+3.5.4.9;MetaCyc: PWY-7909	"Folate transformations II (plants)";"Folate polyglutamylation";"Formate assimilation into 5,10-methylenetetrahydrofolate";"Purine nucleobases degradation II (anaerobic)";"Carbon fixation pathways in prokaryotes";"Carbon fixation pathways in prokaryotes";"Folate transformations I";"Tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate";"One carbon pool by folate";"Metabolism of folate and pterines";"L-histidine degradation III";"One carbon pool by folate";"Formaldehyde oxidation VII (THF pathway)"
XP_046412668.1	1	Reactome: R-HSA-389957	"Prefoldin mediated transfer of substrate to CCT/TriC"
XP_046417583.1	1	Reactome: R-HSA-162791	"Attachment of GPI anchor to uPAR"
XP_046423287.1	1	KEGG: 04660+2.7.10.2	"T cell receptor signaling pathway"
XP_046410282.1	2	Reactome: R-HSA-6804115;Reactome: R-HSA-429947	"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Deadenylation of mRNA"
XP_046430864.1	4	MetaCyc: PWY-7221;Reactome: R-HSA-2161541;KEGG: 00230+2.7.4.8;Reactome: R-HSA-499943	"Guanosine ribonucleotides de novo biosynthesis";"Abacavir metabolism";"Purine metabolism";"Interconversion of nucleotide di- and triphosphates"
XP_046421250.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046420709.1	14	MetaCyc: PWY-5972;Reactome: R-HSA-75876;MetaCyc: PWY-7724;MetaCyc: PWY-6433;MetaCyc: PWY-7035;MetaCyc: PWY-6598;MetaCyc: PWY-7036;MetaCyc: PWY-7602;MetaCyc: PWY-8041;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7601;MetaCyc: PWY-5080;MetaCyc: PWY-7725;MetaCyc: PWY-7619	"Stearate biosynthesis I (animals)";"Synthesis of very long-chain fatty acyl-CoAs";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Hydroxylated fatty acid biosynthesis (plants)";"(9Z)-tricosene biosynthesis";"Sciadonate biosynthesis";"Very long chain fatty acid biosynthesis II";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Ultra-long-chain fatty acid biosynthesis";"Fatty acid elongation";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis I";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Juniperonate biosynthesis"
XP_046409601.1	7	Reactome: R-HSA-3928662;Reactome: R-HSA-418885;Reactome: R-HSA-8856828;Reactome: R-HSA-373753;Reactome: R-HSA-2029482;Reactome: R-HSA-203641;Reactome: R-HSA-5663213	"EPHB-mediated forward signaling";"DCC mediated attractive signaling";"Clathrin-mediated endocytosis";"Nephrin family interactions";"Regulation of actin dynamics for phagocytic cup formation";"NOSTRIN mediated eNOS trafficking";"RHO GTPases Activate WASPs and WAVEs"
XP_046433243.1	1	Reactome: R-HSA-3295583	"TRP channels"
XP_046426466.1	3	Reactome: R-HSA-75109;KEGG: 00561+2.7.1.30;MetaCyc: PWY-4261	"Triglyceride biosynthesis";"Glycerolipid metabolism";"Glycerol degradation I"
XP_046415548.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046433887.1	1	Reactome: R-HSA-380320	"Recruitment of NuMA to mitotic centrosomes"
XP_046431414.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046415652.1	3	Reactome: R-HSA-71262;KEGG: 00310+1.14.11.8;MetaCyc: PWY-6100	"Carnitine synthesis";"Lysine degradation";"L-carnitine biosynthesis"
XP_046419244.1	5	Reactome: R-HSA-1445148;Reactome: R-HSA-6811434;Reactome: R-HSA-983189;Reactome: R-HSA-2132295;Reactome: R-HSA-5620924	"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins";"MHC class II antigen presentation";"Intraflagellar transport"
XP_046416533.1	1	Reactome: R-HSA-163765	"ChREBP activates metabolic gene expression"
XP_046418898.1	6	Reactome: R-HSA-6782135;Reactome: R-HSA-6781823;Reactome: R-HSA-6781827;Reactome: R-HSA-72163;Reactome: R-HSA-6798695;Reactome: R-HSA-6782210	"Dual incision in TC-NER";"Formation of TC-NER Pre-Incision Complex";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"mRNA Splicing - Major Pathway";"Neutrophil degranulation";"Gap-filling DNA repair synthesis and ligation in TC-NER"
XP_046427176.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046418235.1	2	Reactome: R-HSA-5628897;Reactome: R-HSA-611105	"TP53 Regulates Metabolic Genes";"Respiratory electron transport"
XP_046416554.1	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
XP_046428175.1	7	MetaCyc: PWY-7586;KEGG: 00520+5.4.2.8;MetaCyc: PWY-882;MetaCyc: PWY-5659;KEGG: 00051+5.4.2.8;MetaCyc: PWY-7456;Reactome: R-HSA-446205	"Beta-1,4-d-mannosyl-n-acetyl-d-glucosamine degradation";"Amino sugar and nucleotide sugar metabolism";"L-ascorbate biosynthesis I (L-galactose pathway)";"GDP-mannose biosynthesis";"Fructose and mannose metabolism";"Beta-(1,4)-mannan degradation";"Synthesis of GDP-mannose"
XP_046413825.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046422097.1	1	Reactome: R-HSA-6804754	"Regulation of TP53 Expression"
XP_046417350.1	8	Reactome: R-HSA-380972;Reactome: R-HSA-1445148;Reactome: R-HSA-2151209;Reactome: R-HSA-9619483;Reactome: R-HSA-1632852;Reactome: R-HSA-9613354;Reactome: R-HSA-5628897;Reactome: R-HSA-6804756	"Energy dependent regulation of mTOR by LKB1-AMPK";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Activation of PPARGC1A (PGC-1alpha) by phosphorylation";"Activation of AMPK downstream of NMDARs";"Macroautophagy";"Lipophagy";"TP53 Regulates Metabolic Genes";"Regulation of TP53 Activity through Phosphorylation"
XP_046418129.1	1	Reactome: R-HSA-68962	"Activation of the pre-replicative complex"
XP_046414267.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046434903.1	30	Reactome: R-HSA-73776;Reactome: R-HSA-72086;Reactome: R-HSA-674695;Reactome: R-HSA-167200;Reactome: R-HSA-77075;Reactome: R-HSA-6796648;Reactome: R-HSA-73772;Reactome: R-HSA-167152;Reactome: R-HSA-5696395;Reactome: R-HSA-167161;Reactome: R-HSA-76042;Reactome: R-HSA-75955;Reactome: R-HSA-167172;Reactome: R-HSA-73863;Reactome: R-HSA-112382;Reactome: R-HSA-5696400;Reactome: R-HSA-167158;Reactome: R-HSA-6781827;Reactome: R-HSA-2564830;Reactome: R-HSA-6782135;Reactome: R-HSA-73779;Reactome: R-HSA-167160;Reactome: R-HSA-73762;Reactome: R-HSA-75953;Reactome: R-HSA-427413;Reactome: R-HSA-167162;Reactome: R-HSA-6781823;Reactome: R-HSA-167246;Reactome: R-HSA-6782210;Reactome: R-HSA-113418	"RNA Polymerase II Promoter Escape";"mRNA Capping";"RNA Polymerase II Pre-transcription Events";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Pol II CTD phosphorylation and interaction with CE";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase I Promoter Escape";"Formation of HIV elongation complex in the absence of HIV Tat";"Formation of Incision Complex in GG-NER";"HIV Transcription Initiation";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II Transcription Elongation";"Transcription of the HIV genome";"RNA Polymerase I Transcription Termination";"Formation of RNA Pol II elongation complex";"Dual Incision in GG-NER";"Formation of the HIV-1 Early Elongation Complex";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Cytosolic iron-sulfur cluster assembly";"Dual incision in TC-NER";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"RNA Polymerase I Transcription Initiation";"RNA Polymerase II Transcription Initiation";"NoRC negatively regulates rRNA expression";"RNA Polymerase II HIV Promoter Escape";"Formation of TC-NER Pre-Incision Complex";"Tat-mediated elongation of the HIV-1 transcript";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Formation of the Early Elongation Complex"
XP_046428649.1	1	Reactome: R-HSA-525793	"Myogenesis"
XP_046420547.1	2	Reactome: R-HSA-383280;Reactome: R-HSA-983231	"Nuclear Receptor transcription pathway";"Factors involved in megakaryocyte development and platelet production"
XP_046426789.1	6	KEGG: 00564+1.1.5.3;Reactome: R-HSA-1483166;Reactome: R-HSA-163560;MetaCyc: PWY-6118;MetaCyc: PWY-6952;MetaCyc: PWY-4261	"Glycerophospholipid metabolism";"Synthesis of PA";"Triglyceride catabolism";"Glycerol-3-phosphate shuttle";"Glycerophosphodiester degradation";"Glycerol degradation I"
XP_046435010.1	2	Reactome: R-HSA-163282;Reactome: R-HSA-2151201	"Mitochondrial transcription initiation";"Transcriptional activation of mitochondrial biogenesis"
XP_046431990.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_046422744.1	22	Reactome: R-HSA-6811558;Reactome: R-HSA-5467340;Reactome: R-HSA-5358747;Reactome: R-HSA-9648025;Reactome: R-HSA-5358751;Reactome: R-HSA-141444;Reactome: R-HSA-2467813;Reactome: R-HSA-195253;Reactome: R-HSA-5358752;Reactome: R-HSA-2500257;Reactome: R-HSA-5673000;Reactome: R-HSA-389513;Reactome: R-HSA-5675221;Reactome: R-HSA-432142;Reactome: R-HSA-5339716;Reactome: R-HSA-4641262;Reactome: R-HSA-68877;Reactome: R-HSA-5467348;Reactome: R-HSA-5467337;Reactome: R-HSA-5663220;Reactome: R-HSA-196299;Reactome: R-HSA-5358749	"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"AXIN missense mutants destabilize the destruction complex";"S33 mutants of beta-catenin aren't phosphorylated";"EML4 and NUDC in mitotic spindle formation";"S45 mutants of beta-catenin aren't phosphorylated";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Separation of Sister Chromatids";"Degradation of beta-catenin by the destruction complex";"T41 mutants of beta-catenin aren't phosphorylated";"Resolution of Sister Chromatid Cohesion";"RAF activation";"CTLA4 inhibitory signaling";"Negative regulation of MAPK pathway";"Platelet sensitization by LDL";"Misspliced GSK3beta mutants stabilize beta-catenin";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"Mitotic Prometaphase";"Truncations of AMER1 destabilize the destruction complex";"APC truncation mutants have impaired AXIN binding";"RHO GTPases Activate Formins";"Beta-catenin phosphorylation cascade";"S37 mutants of beta-catenin aren't phosphorylated"
XP_046415318.1	14	Reactome: R-HSA-141444;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813;Reactome: R-HSA-9646399;Reactome: R-HSA-6811436;Reactome: R-HSA-68877;Reactome: R-HSA-9609690;Reactome: R-HSA-2132295;Reactome: R-HSA-3371497;Reactome: R-HSA-1632852;Reactome: R-HSA-6807878;Reactome: R-HSA-5620924;Reactome: R-HSA-2500257;Reactome: R-HSA-5663220	"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids";"Aggrephagy";"COPI-independent Golgi-to-ER retrograde traffic";"Mitotic Prometaphase";"HCMV Early Events";"MHC class II antigen presentation";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Macroautophagy";"COPI-mediated anterograde transport";"Intraflagellar transport";"Resolution of Sister Chromatid Cohesion";"RHO GTPases Activate Formins"
XP_046421440.1	5	Reactome: R-HSA-917729;Reactome: R-HSA-174490;Reactome: R-HSA-9610379;Reactome: R-HSA-162588;Reactome: R-HSA-9615710	"Endosomal Sorting Complex Required For Transport (ESCRT)";"Membrane binding and targetting of GAG proteins";"HCMV Late Events";"Budding and maturation of HIV virion";"Late endosomal microautophagy"
XP_046410257.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_046434693.1	3	Reactome: R-HSA-74217;KEGG: 00230+3.5.4.6;MetaCyc: PWY-6596	"Purine salvage";"Purine metabolism";"Adenosine nucleotides degradation I"
XP_046414342.1	13	MetaCyc: PWY-8052;MetaCyc: PWY-6367;KEGG: 04070+3.1.4.11;Reactome: R-HSA-2029485;Reactome: R-HSA-9027277;Reactome: R-HSA-2871796;Reactome: R-HSA-1855204;KEGG: 00562+3.1.4.11;Reactome: R-HSA-202433;Reactome: R-HSA-2871809;Reactome: R-HSA-2424491;MetaCyc: PWY-7039;MetaCyc: PWY-6351	"2-arachidonoylglycerol biosynthesis";"D-myo-inositol-5-phosphate metabolism";"Phosphatidylinositol signaling system";"Role of phospholipids in phagocytosis";"Erythropoietin activates Phospholipase C gamma (PLCG)";"FCERI mediated MAPK activation";"Synthesis of IP3 and IP4 in the cytosol";"Inositol phosphate metabolism";"Generation of second messenger molecules";"FCERI mediated Ca+2 mobilization";"DAP12 signaling";"Phosphatidate metabolism, as a signaling molecule";"D-myo-inositol (1,4,5)-trisphosphate biosynthesis"
XP_046409299.1	3	Reactome: R-HSA-74217;KEGG: 00230+2.7.1.20;MetaCyc: PWY-6619	"Purine salvage";"Purine metabolism";"Adenine and adenosine salvage VI"
XP_046420615.1	1	Reactome: R-HSA-400253	"Circadian Clock"
XP_046435534.1	2	Reactome: R-HSA-2151201;Reactome: R-HSA-400253	"Transcriptional activation of mitochondrial biogenesis";"Circadian Clock"
XP_046409743.1	1	Reactome: R-HSA-429958	"mRNA decay by 3' to 5' exoribonuclease"
XP_046411247.1	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
XP_046436020.1	7	Reactome: R-HSA-73863;Reactome: R-HSA-5250924;Reactome: R-HSA-73772;Reactome: R-HSA-73762;Reactome: R-HSA-6811434;Reactome: R-HSA-983189;Reactome: R-HSA-427413	"RNA Polymerase I Transcription Termination";"B-WICH complex positively regulates rRNA expression";"RNA Polymerase I Promoter Escape";"RNA Polymerase I Transcription Initiation";"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins";"NoRC negatively regulates rRNA expression"
XP_046433976.1	6	Reactome: R-HSA-5693568;Reactome: R-HSA-5685942;Reactome: R-HSA-5693554;Reactome: R-HSA-5693616;Reactome: R-HSA-912446;Reactome: R-HSA-5693579	"Resolution of D-loop Structures through Holliday Junction Intermediates";"HDR through Homologous Recombination (HRR)";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Presynaptic phase of homologous DNA pairing and strand exchange";"Meiotic recombination";"Homologous DNA Pairing and Strand Exchange"
XP_046410642.1	1	Reactome: R-HSA-8949664	"Processing of SMDT1"
XP_046427297.1	6	Reactome: R-HSA-8949613;MetaCyc: PWY-7980;Reactome: R-HSA-1268020;KEGG: 00190+7.1.2.2;KEGG: 00195+7.1.2.2;Reactome: R-HSA-163210	"Cristae formation";"ATP biosynthesis";"Mitochondrial protein import";"Oxidative phosphorylation";"Photosynthesis";"Formation of ATP by chemiosmotic coupling"
XP_046413045.1	1	KEGG: 00970+6.1.1.9	"Aminoacyl-tRNA biosynthesis"
XP_046421959.1	2	Reactome: R-HSA-418457;Reactome: R-HSA-1296052	"cGMP effects";"Ca2+ activated K+ channels"
XP_046426369.1	2	Reactome: R-HSA-2022854;Reactome: R-HSA-975577	"Keratan sulfate biosynthesis";"N-Glycan antennae elongation"
XP_046418119.1	6	KEGG: 00052+3.2.1.23;KEGG: 00604+3.2.1.23;MetaCyc: PWY-6807;KEGG: 00600+3.2.1.23;KEGG: 00511+3.2.1.23;KEGG: 00531+3.2.1.23	"Galactose metabolism";"Glycosphingolipid biosynthesis - ganglio series";"Xyloglucan degradation II (exoglucanase)";"Sphingolipid metabolism";"Other glycan degradation";"Glycosaminoglycan degradation"
XP_046430945.1	1	Reactome: R-HSA-8854691	"Interleukin-20 family signaling"
XP_046411571.1	7	Reactome: R-HSA-76071;Reactome: R-HSA-1834949;Reactome: R-HSA-749476;Reactome: R-HSA-73980;Reactome: R-HSA-73780;Reactome: R-HSA-76061;Reactome: R-HSA-76066	"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Termination";"RNA Polymerase III Chain Elongation";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Transcription Initiation From Type 2 Promoter"
XP_046417173.1	2	Reactome: R-HSA-1660662;Reactome: R-HSA-390471	"Glycosphingolipid metabolism";"Association of TriC/CCT with target proteins during biosynthesis"
XP_046412197.1	2	Reactome: R-HSA-1169408;Reactome: R-HSA-168276	"ISG15 antiviral mechanism";"NS1 Mediated Effects on Host Pathways"
XP_046436445.1	5	Reactome: R-HSA-450321;Reactome: R-HSA-2559580;Reactome: R-HSA-450341;KEGG: 04150+2.7.11.24;Reactome: R-HSA-2871796	"JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1";"Oxidative Stress Induced Senescence";"Activation of the AP-1 family of transcription factors";"mTOR signaling pathway";"FCERI mediated MAPK activation"
XP_046409482.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046434840.1	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
XP_046433647.1	3	Reactome: R-HSA-9609523;Reactome: R-HSA-6798695;Reactome: R-HSA-1660661	"Insertion of tail-anchored proteins into the endoplasmic reticulum membrane";"Neutrophil degranulation";"Sphingolipid de novo biosynthesis"
XP_046428814.1	1	Reactome: R-HSA-264876	"Insulin processing"
XP_046412049.1	3	Reactome: R-HSA-983189;Reactome: R-HSA-6811434;Reactome: R-HSA-390471	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic";"Association of TriC/CCT with target proteins during biosynthesis"
XP_046422632.1	2	Reactome: R-HSA-5696394;Reactome: R-HSA-5689603	"DNA Damage Recognition in GG-NER";"UCH proteinases"
XP_046412553.1	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
XP_046426010.1	20	MetaCyc: PWY-7337;MetaCyc: PWY-7574;MetaCyc: PWY-7340;MetaCyc: PWY-7288;MetaCyc: PWY-7726;MetaCyc: PWY-7606;MetaCyc: PWY-7007;MetaCyc: PWY-7854;MetaCyc: PWY-5136;Reactome: R-HSA-9033241;KEGG: 00410+1.3.3.6;MetaCyc: PWY-6837;KEGG: 00640+1.3.3.6;KEGG: 00592+1.3.3.6;MetaCyc: PWY-735;MetaCyc: PWY-7338;KEGG: 00071+1.3.3.6;MetaCyc: PWY-6920;MetaCyc: PWY-7291;MetaCyc: PWY-7858	"10-cis-heptadecenoyl-CoA degradation (yeast)";"Propanoyl-coa degradation II";"9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast)";"Fatty acid beta-oxidation VII (yeast peroxisome)";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Methyl ketone biosynthesis (engineered)";"Crotonyl-coa/ethylmalonyl-coa/hydroxybutyryl-coa cycle (engineered)";"Fatty acid beta-oxidation II (plant peroxisome)";"Peroxisomal protein import";"beta-Alanine metabolism";"Fatty acid beta-oxidation V (unsaturated, odd number, di-isomerase-dependent)";"Propanoate metabolism";"alpha-Linolenic acid metabolism";"Jasmonic acid biosynthesis";"10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast)";"Fatty acid degradation";"6-gingerol analog biosynthesis (engineered)";"Oleate beta-oxidation (isomerase-dependent, yeast)";"(5Z)-dodecenoate biosynthesis II"
XP_046431868.1	8	Reactome: R-HSA-8856828;Reactome: R-HSA-3928665;Reactome: R-HSA-432720;Reactome: R-HSA-190873;Reactome: R-HSA-5140745;Reactome: R-HSA-5099900;Reactome: R-HSA-8856825;Reactome: R-HSA-196025	"Clathrin-mediated endocytosis";"EPH-ephrin mediated repulsion of cells";"Lysosome Vesicle Biogenesis";"Gap junction degradation";"WNT5A-dependent internalization of FZD2, FZD5 and ROR2";"WNT5A-dependent internalization of FZD4";"Cargo recognition for clathrin-mediated endocytosis";"Formation of annular gap junctions"
XP_046427951.1	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
XP_046411395.1	5	MetaCyc: PWY-7269;KEGG: 00760+2.7.1.23;MetaCyc: PWY-5083;Reactome: R-HSA-196807;MetaCyc: PWY-7268	"NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)";"Nicotinate and nicotinamide metabolism";"NAD/NADH phosphorylation and dephosphorylation";"Nicotinate metabolism";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)"
XP_046409809.1	4	KEGG: 00514+2.4.1.255;Reactome: R-HSA-3214847;MetaCyc: PWY-7437;Reactome: R-HSA-5689603	"Other types of O-glycan biosynthesis";"HATs acetylate histones";"Protein O-[N-acetyl]-glucosylation";"UCH proteinases"
XP_046435526.1	2	Reactome: R-HSA-400253;Reactome: R-HSA-2151201	"Circadian Clock";"Transcriptional activation of mitochondrial biogenesis"
XP_046414437.1	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
XP_046429147.1	4	Reactome: R-HSA-3371497;Reactome: R-HSA-6811436;Reactome: R-HSA-6807878;Reactome: R-HSA-2132295	"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-independent Golgi-to-ER retrograde traffic";"COPI-mediated anterograde transport";"MHC class II antigen presentation"
XP_046422588.1	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046428769.1	7	KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1	"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Relaxin signaling pathway";"Thermogenesis";"Human cytomegalovirus infection"
XP_046423660.1	1	Reactome: R-HSA-419037	"NCAM1 interactions"
XP_046412338.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_046434731.1	11	Reactome: R-HSA-9013695;Reactome: R-HSA-8941856;Reactome: R-HSA-2894862;Reactome: R-HSA-210744;Reactome: R-HSA-1912408;Reactome: R-HSA-2644606;Reactome: R-HSA-9013508;Reactome: R-HSA-72163;Reactome: R-HSA-2122947;Reactome: R-HSA-2173796;Reactome: R-HSA-350054	"NOTCH4 Intracellular Domain Regulates Transcription";"RUNX3 regulates NOTCH signaling";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"Pre-NOTCH Transcription and Translation";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH3 Intracellular Domain Regulates Transcription";"mRNA Splicing - Major Pathway";"NOTCH1 Intracellular Domain Regulates Transcription";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"Notch-HLH transcription pathway"
XP_046413203.1	7	KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1	"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Relaxin signaling pathway";"Thermogenesis";"Human cytomegalovirus infection"
XP_046436701.1	3	MetaCyc: PWY-7894;KEGG: 00330+1.14.11.2;Reactome: R-HSA-1650814	"Procollagen hydroxylation and glycosylation";"Arginine and proline metabolism";"Collagen biosynthesis and modifying enzymes"
XP_046431495.1	2	Reactome: R-HSA-373080;Reactome: R-HSA-3238698	"Class B/2 (Secretin family receptors)";"WNT ligand biogenesis and trafficking"
XP_046424075.1	13	Reactome: R-HSA-72689;Reactome: R-HSA-9633012;Reactome: R-HSA-192823;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-2408557;Reactome: R-HSA-72706;Reactome: R-HSA-1799339;Reactome: R-HSA-975957;Reactome: R-HSA-6791226;Reactome: R-HSA-975956;Reactome: R-HSA-156902;Reactome: R-HSA-72764	"Formation of a pool of free 40S subunits";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Selenocysteine synthesis";"GTP hydrolysis and joining of the 60S ribosomal subunit";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Peptide chain elongation";"Eukaryotic Translation Termination"
XP_046421166.1	3	Reactome: R-HSA-2514859;MetaCyc: PWY-7799;MetaCyc: PWY-7800	"Inactivation, recovery and regulation of the phototransduction cascade";"Arg/N-end rule pathway (eukaryotic)";"Ac/N-end rule pathway"
XP_046429842.1	1	KEGG: 00970+6.1.1.22	"Aminoacyl-tRNA biosynthesis"
XP_046422332.1	1	Reactome: R-HSA-5663220	"RHO GTPases Activate Formins"
XP_046412146.1	1	Reactome: R-HSA-9616222	"Transcriptional regulation of granulopoiesis"
XP_046417221.1	24	Reactome: R-HSA-5617833;Reactome: R-HSA-2132295;Reactome: R-HSA-8955332;Reactome: R-HSA-9609736;Reactome: R-HSA-8852276;Reactome: R-HSA-68877;Reactome: R-HSA-190840;Reactome: R-HSA-6811436;Reactome: R-HSA-9646399;Reactome: R-HSA-190861;Reactome: R-HSA-5663220;Reactome: R-HSA-437239;Reactome: R-HSA-3371497;Reactome: R-HSA-6811434;Reactome: R-HSA-9648025;Reactome: R-HSA-380320;Reactome: R-HSA-9609690;Reactome: R-HSA-2467813;Reactome: R-HSA-9619483;Reactome: R-HSA-1445148;Reactome: R-HSA-983189;Reactome: R-HSA-2500257;Reactome: R-HSA-5626467;Reactome: R-HSA-6807878	"Cilium Assembly";"MHC class II antigen presentation";"Carboxyterminal post-translational modifications of tubulin";"Assembly and cell surface presentation of NMDA receptors";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Mitotic Prometaphase";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"COPI-independent Golgi-to-ER retrograde traffic";"Aggrephagy";"Gap junction assembly";"RHO GTPases Activate Formins";"Recycling pathway of L1";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-dependent Golgi-to-ER retrograde traffic";"EML4 and NUDC in mitotic spindle formation";"Recruitment of NuMA to mitotic centrosomes";"HCMV Early Events";"Separation of Sister Chromatids";"Activation of AMPK downstream of NMDARs";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Kinesins";"Resolution of Sister Chromatid Cohesion";"RHO GTPases activate IQGAPs";"COPI-mediated anterograde transport"
XP_046419528.1	1	Reactome: R-HSA-975957	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
XP_046422330.1	1	Reactome: R-HSA-5663220	"RHO GTPases Activate Formins"
XP_046421043.1	5	KEGG: 00380+1.2.4.2;KEGG: 00310+1.2.4.2;MetaCyc: PWY-5084;KEGG: 00020+1.2.4.2;Reactome: R-HSA-389661	"Tryptophan metabolism";"Lysine degradation";"2-oxoglutarate decarboxylation to succinyl-CoA";"Citrate cycle (TCA cycle)";"Glyoxylate metabolism and glycine degradation"
XP_046412988.1	25	Reactome: R-HSA-8940973;Reactome: R-HSA-8935964;Reactome: R-HSA-8939247;Reactome: R-HSA-8939243;Reactome: R-HSA-8941858;Reactome: R-HSA-8878166;Reactome: R-HSA-8951911;Reactome: R-HSA-8939902;Reactome: R-HSA-9018519;Reactome: R-HSA-8939245;Reactome: R-HSA-8936459;Reactome: R-HSA-8939246;Reactome: R-HSA-8931987;Reactome: R-HSA-8941332;Reactome: R-HSA-8939256;Reactome: R-HSA-8941326;Reactome: R-HSA-8941333;Reactome: R-HSA-8939242;Reactome: R-HSA-9616222;Reactome: R-HSA-8949275;Reactome: R-HSA-8877330;Reactome: R-HSA-8934593;Reactome: R-HSA-8939236;Reactome: R-HSA-8941284;Reactome: R-HSA-8951936	"RUNX2 regulates osteoblast differentiation";"RUNX1 regulates expression of components of tight junctions";"RUNX1 regulates transcription of genes involved in interleukin signaling";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"Regulation of RUNX3 expression and activity";"Transcriptional regulation by RUNX2";"RUNX3 regulates RUNX1-mediated transcription";"Regulation of RUNX2 expression and activity";"Estrogen-dependent gene expression";"RUNX1 regulates transcription of genes involved in BCR signaling";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"RUNX1 regulates transcription of genes involved in differentiation of myeloid cells";"RUNX1 regulates estrogen receptor mediated transcription";"RUNX2 regulates genes involved in cell migration";"RUNX1 regulates transcription of genes involved in WNT signaling";"RUNX2 regulates bone development";"RUNX2 regulates genes involved in differentiation of myeloid cells";"RUNX1 regulates transcription of genes involved in differentiation of keratinocytes";"Transcriptional regulation of granulopoiesis";"RUNX3 Regulates Immune Response and Cell Migration";"RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)";"Regulation of RUNX1 Expression and Activity";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"RUNX2 regulates chondrocyte maturation";"RUNX3 regulates p14-ARF"
XP_046411196.1	1	Reactome: R-HSA-202733	"Cell surface interactions at the vascular wall"
XP_046414494.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046425441.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046421105.1	4	MetaCyc: PWY-7382;KEGG: 00785+2.3.1.181;Reactome: R-HSA-389661;MetaCyc: PWY-6987	"Lipoate biosynthesis and incorporation IV (yeast)";"Lipoic acid metabolism";"Glyoxylate metabolism and glycine degradation";"Lipoate biosynthesis and incorporation III (Bacillus)"
XP_046436608.1	1	Reactome: R-HSA-6799198	"Complex I biogenesis"
XP_046431522.1	5	Reactome: R-HSA-111463;Reactome: R-HSA-9627069;Reactome: R-HSA-111457;Reactome: R-HSA-111464;Reactome: R-HSA-111469	"SMAC (DIABLO) binds to IAPs";"Regulation of the apoptosome activity";"Release of apoptotic factors from the mitochondria";"SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes";"SMAC, XIAP-regulated apoptotic response"
XP_046433595.1	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_046410391.1	13	Reactome: R-HSA-192823;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-9633012;Reactome: R-HSA-72689;Reactome: R-HSA-1799339;Reactome: R-HSA-2408557;Reactome: R-HSA-72706;Reactome: R-HSA-6791226;Reactome: R-HSA-975957;Reactome: R-HSA-72764;Reactome: R-HSA-975956;Reactome: R-HSA-156902	"Viral mRNA Translation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Formation of a pool of free 40S subunits";"SRP-dependent cotranslational protein targeting to membrane";"Selenocysteine synthesis";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Peptide chain elongation"
XP_046422125.1	3	KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16	"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
XP_046429567.1	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
XP_046416632.1	7	Reactome: R-HSA-4086400;Reactome: R-HSA-5368598;Reactome: R-HSA-201681;Reactome: R-HSA-201688;Reactome: R-HSA-4641258;Reactome: R-HSA-4641262;Reactome: R-HSA-5663220	"PCP/CE pathway";"Negative regulation of TCF-dependent signaling by DVL-interacting proteins";"TCF dependent signaling in response to WNT";"WNT mediated activation of DVL";"Degradation of DVL";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"RHO GTPases Activate Formins"
XP_046413209.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046432835.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_046414127.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_046416536.1	6	Reactome: R-HSA-73856;Reactome: R-HSA-975957;Reactome: R-HSA-72163;Reactome: R-HSA-9010553;Reactome: R-HSA-159236;Reactome: R-HSA-72187	"RNA Polymerase II Transcription Termination";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"mRNA Splicing - Major Pathway";"Regulation of expression of SLITs and ROBOs";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"mRNA 3'-end processing"
XP_046419071.1	1	Reactome: R-HSA-5658442	"Regulation of RAS by GAPs"
XP_046412236.1	1	Reactome: R-HSA-8866654	"E3 ubiquitin ligases ubiquitinate target proteins"
XP_046436033.1	14	MetaCyc: PWY-6728;MetaCyc: PWY-6969;MetaCyc: PWY-4302;MetaCyc: PWY-7254;MetaCyc: PWY-561;MetaCyc: PWY-3781;MetaCyc: PWY-7279;Reactome: R-HSA-71403;MetaCyc: PWY-5690;KEGG: 00190+1.3.5.1;KEGG: 00020+1.3.5.1;KEGG: 00720+1.3.5.1;Reactome: R-HSA-611105;KEGG: 00650+1.3.5.1	"Methylaspartate cycle";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Aerobic respiration III (alternative oxidase pathway)";"TCA cycle VII (acetate-producers)";"Superpathway of glyoxylate cycle and fatty acid degradation";"Aerobic respiration I (cytochrome c)";"Aerobic respiration II (cytochrome c) (yeast)";"Citric acid cycle (TCA cycle)";"TCA cycle II (plants and fungi)";"Oxidative phosphorylation";"Citrate cycle (TCA cycle)";"Carbon fixation pathways in prokaryotes";"Respiratory electron transport";"Butanoate metabolism"
XP_046429495.1	5	KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16;Reactome: R-HSA-5687128;KEGG: 05235+3.1.3.16;Reactome: R-HSA-176407	"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation";"MAPK6/MAPK4 signaling";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase"
XP_046412149.1	1	Reactome: R-HSA-6814848	"Glycerophospholipid catabolism"
XP_046428096.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_046432141.1	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
XP_046410269.1	2	KEGG: 00620+3.1.2.6;MetaCyc: PWY-5386	"Pyruvate metabolism";"Methylglyoxal degradation I"
XP_046421294.1	3	Reactome: R-HSA-5423646;MetaCyc: PWY-7533;Reactome: R-HSA-2142691	"Aflatoxin activation and detoxification";"Gliotoxin biosynthesis";"Synthesis of Leukotrienes (LT) and Eoxins (EX)"
XP_046428174.1	7	Reactome: R-HSA-446205;MetaCyc: PWY-5659;KEGG: 00051+5.4.2.8;MetaCyc: PWY-7456;MetaCyc: PWY-882;KEGG: 00520+5.4.2.8;MetaCyc: PWY-7586	"Synthesis of GDP-mannose";"GDP-mannose biosynthesis";"Fructose and mannose metabolism";"Beta-(1,4)-mannan degradation";"L-ascorbate biosynthesis I (L-galactose pathway)";"Amino sugar and nucleotide sugar metabolism";"Beta-1,4-d-mannosyl-n-acetyl-d-glucosamine degradation"
XP_046412347.1	1	Reactome: R-HSA-71064	"Lysine catabolism"
XP_046419132.1	2	Reactome: R-HSA-380095;Reactome: R-HSA-416476	"Tachykinin receptors bind tachykinins";"G alpha (q) signalling events"
XP_046416790.1	5	Reactome: R-HSA-3656237;Reactome: R-HSA-2022928;Reactome: R-HSA-3656253;KEGG: 00534+2.4.1.224+2.4.1.225;MetaCyc: PWY-6558	"Defective EXT2 causes exostoses 2";"HS-GAG biosynthesis";"Defective EXT1 causes exostoses 1, TRPS2 and CHDS";"Glycosaminoglycan biosynthesis - heparan sulfate / heparin";"Heparan sulfate biosynthesis (late stages)"
XP_046430680.1	3	MetaCyc: PWY-3961;KEGG: 00770+2.7.1.33;Reactome: R-HSA-196783	"Phosphopantothenate biosynthesis II";"Pantothenate and CoA biosynthesis";"Coenzyme A biosynthesis"
XP_046420650.1	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
XP_046431335.1	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
XP_046413609.1	1	Reactome: R-HSA-5689877	"Josephin domain DUBs"
XP_046428507.1	1	Reactome: R-HSA-1799339	"SRP-dependent cotranslational protein targeting to membrane"
XP_046424631.1	5	Reactome: R-HSA-5221030;Reactome: R-HSA-110328;Reactome: R-HSA-110329;Reactome: R-HSA-110357;Reactome: R-HSA-3108214	"TET1,2,3 and TDG demethylate DNA";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"Cleavage of the damaged pyrimidine";"Displacement of DNA glycosylase by APEX1";"SUMOylation of DNA damage response and repair proteins"
XP_046429677.1	15	Reactome: R-HSA-1912408;Reactome: R-HSA-8943723;Reactome: R-HSA-4086398;Reactome: R-HSA-8986944;Reactome: R-HSA-2559585;Reactome: R-HSA-5628897;Reactome: R-HSA-8948700;Reactome: R-HSA-9018519;Reactome: R-HSA-8934593;Reactome: R-HSA-8936459;Reactome: R-HSA-9029569;Reactome: R-HSA-2559580;Reactome: R-HSA-9022692;Reactome: R-HSA-8853884;Reactome: R-HSA-5687128	"Pre-NOTCH Transcription and Translation";"Regulation of PTEN mRNA translation";"Ca2+ pathway";"Transcriptional Regulation by MECP2";"Oncogene Induced Senescence";"TP53 Regulates Metabolic Genes";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"Estrogen-dependent gene expression";"Regulation of RUNX1 Expression and Activity";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Oxidative Stress Induced Senescence";"Regulation of MECP2 expression and activity";"Transcriptional Regulation by VENTX";"MAPK6/MAPK4 signaling"
XP_046428172.1	7	KEGG: 00520+5.4.2.8;MetaCyc: PWY-882;MetaCyc: PWY-7586;Reactome: R-HSA-446205;MetaCyc: PWY-5659;KEGG: 00051+5.4.2.8;MetaCyc: PWY-7456	"Amino sugar and nucleotide sugar metabolism";"L-ascorbate biosynthesis I (L-galactose pathway)";"Beta-1,4-d-mannosyl-n-acetyl-d-glucosamine degradation";"Synthesis of GDP-mannose";"GDP-mannose biosynthesis";"Fructose and mannose metabolism";"Beta-(1,4)-mannan degradation"
XP_046427819.1	4	Reactome: R-HSA-6799198;Reactome: R-HSA-611105;Reactome: R-HSA-77289;Reactome: R-HSA-389661	"Complex I biogenesis";"Respiratory electron transport";"Mitochondrial Fatty Acid Beta-Oxidation";"Glyoxylate metabolism and glycine degradation"
XP_046426938.1	6	MetaCyc: PWY-5497;KEGG: 00230+3.5.4.3;MetaCyc: PWY-6608;MetaCyc: PWY-6606;MetaCyc: PWY-7442;Reactome: R-HSA-74259	"Purine nucleobases degradation II (anaerobic)";"Purine metabolism";"Guanosine nucleotides degradation III";"Guanosine nucleotides degradation II";"Drosopterin and aurodrosopterin biosynthesis";"Purine catabolism"
XP_046436135.1	1	Reactome: R-HSA-6802952	"Signaling by BRAF and RAF fusions"
XP_046415269.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_046412648.1	4	Reactome: R-HSA-2644606;Reactome: R-HSA-2122947;Reactome: R-HSA-2894862;Reactome: R-HSA-350054	"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH1 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Notch-HLH transcription pathway"
XP_046435075.1	7	KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1	"Thermogenesis";"Human cytomegalovirus infection";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Relaxin signaling pathway";"mTOR signaling pathway";"PI3K-Akt signaling pathway"
XP_046423349.1	2	Reactome: R-HSA-180024;KEGG: 00230+3.1.4.53	"DARPP-32 events";"Purine metabolism"
XP_046428858.1	4	MetaCyc: PWY-6803;MetaCyc: PWY-8051;KEGG: 00592+3.1.1.32;KEGG: 00564+3.1.1.32	"Phosphatidylcholine acyl editing";"Anandamide biosynthesis I";"alpha-Linolenic acid metabolism";"Glycerophospholipid metabolism"
XP_046435361.1	6	Reactome: R-HSA-1474151;MetaCyc: PWY-5663;MetaCyc: PWY-7442;MetaCyc: PWY-6983;KEGG: 00790+4.2.3.12;MetaCyc: PWY-5664	"Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation";"Erythro-tetrahydrobiopterin biosynthesis I";"Drosopterin and aurodrosopterin biosynthesis";"Threo-tetrahydrobiopterin biosynthesis";"Folate biosynthesis";"Erythro-tetrahydrobiopterin biosynthesis II"
XP_046421901.1	3	KEGG: 00860+2.5.1.141;MetaCyc: PWY-7856;Reactome: R-HSA-189451	"Porphyrin and chlorophyll metabolism";"Heme a biosynthesis";"Heme biosynthesis"
XP_046427763.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_046416224.1	1	Reactome: R-HSA-2514853	"Condensation of Prometaphase Chromosomes"
XP_046428662.1	4	KEGG: 00564+3.1.1.32;MetaCyc: PWY-6803;KEGG: 00592+3.1.1.32;MetaCyc: PWY-8051	"Glycerophospholipid metabolism";"Phosphatidylcholine acyl editing";"alpha-Linolenic acid metabolism";"Anandamide biosynthesis I"
XP_046421899.1	3	KEGG: 00860+2.5.1.141;Reactome: R-HSA-189451;MetaCyc: PWY-7856	"Porphyrin and chlorophyll metabolism";"Heme biosynthesis";"Heme a biosynthesis"
XP_046414211.1	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
XP_046431964.1	8	KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;Reactome: R-HSA-418889;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1	"Human cytomegalovirus infection";"Relaxin signaling pathway";"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Caspase activation via Dependence Receptors in the absence of ligand";"Thermogenesis";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection"
XP_046416340.1	1	Reactome: R-HSA-1483255	"PI Metabolism"
XP_046435313.1	3	KEGG: 00730+3.1.3.2;MetaCyc: PWY-6348;KEGG: 00740+3.1.3.2	"Thiamine metabolism";"Phosphate acquisition";"Riboflavin metabolism"
XP_046426566.1	1	Reactome: R-HSA-5693571	"Nonhomologous End-Joining (NHEJ)"
XP_046412432.1	2	Reactome: R-HSA-9010553;Reactome: R-HSA-975957	"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
XP_046424591.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046425121.1	10	KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04714+2.7.11.1;Reactome: R-HSA-442742;Reactome: R-HSA-437239;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;Reactome: R-HSA-444257	"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Thermogenesis";"CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling";"Recycling pathway of L1";"Relaxin signaling pathway";"Human cytomegalovirus infection";"mTOR signaling pathway";"PI3K-Akt signaling pathway";"RSK activation"
XP_046435892.1	3	Reactome: R-HSA-6807878;Reactome: R-HSA-8963901;Reactome: R-HSA-445095	"COPI-mediated anterograde transport";"Chylomicron remodeling";"Interaction between L1 and Ankyrins"
XP_046424407.1	1	Reactome: R-HSA-8856828	"Clathrin-mediated endocytosis"
XP_046419420.1	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046435161.1	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
XP_046423904.1	6	Reactome: R-HSA-450604;Reactome: R-HSA-450513;Reactome: R-HSA-429958;Reactome: R-HSA-380994;Reactome: R-HSA-6791226;Reactome: R-HSA-450385	"KSRP (KHSRP) binds and destabilizes mRNA";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"mRNA decay by 3' to 5' exoribonuclease";"ATF4 activates genes in response to endoplasmic reticulum stress";"Major pathway of rRNA processing in the nucleolus and cytosol";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA"
XP_046413158.1	1	Reactome: R-HSA-156842	"Eukaryotic Translation Elongation"
XP_046415315.1	14	Reactome: R-HSA-2467813;Reactome: R-HSA-9646399;Reactome: R-HSA-6811436;Reactome: R-HSA-68877;Reactome: R-HSA-9609690;Reactome: R-HSA-141444;Reactome: R-HSA-9648025;Reactome: R-HSA-2132295;Reactome: R-HSA-1632852;Reactome: R-HSA-6807878;Reactome: R-HSA-3371497;Reactome: R-HSA-2500257;Reactome: R-HSA-5663220;Reactome: R-HSA-5620924	"Separation of Sister Chromatids";"Aggrephagy";"COPI-independent Golgi-to-ER retrograde traffic";"Mitotic Prometaphase";"HCMV Early Events";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"EML4 and NUDC in mitotic spindle formation";"MHC class II antigen presentation";"Macroautophagy";"COPI-mediated anterograde transport";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Resolution of Sister Chromatid Cohesion";"RHO GTPases Activate Formins";"Intraflagellar transport"
XP_046420653.1	2	Reactome: R-HSA-429947;Reactome: R-HSA-6804115	"Deadenylation of mRNA";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"
XP_046435860.1	2	Reactome: R-HSA-6804115;Reactome: R-HSA-429947	"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Deadenylation of mRNA"
XP_046421603.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_046421952.1	2	Reactome: R-HSA-418457;Reactome: R-HSA-1296052	"cGMP effects";"Ca2+ activated K+ channels"
XP_046429150.1	5	Reactome: R-HSA-1989781;Reactome: R-HSA-211976;Reactome: R-HSA-211981;Reactome: R-HSA-211945;Reactome: R-HSA-8937144	"PPARA activates gene expression";"Endogenous sterols";"Xenobiotics";"Phase I - Functionalization of compounds";"Aryl hydrocarbon receptor signalling"
XP_046428664.1	4	KEGG: 00564+3.1.1.32;MetaCyc: PWY-8051;KEGG: 00592+3.1.1.32;MetaCyc: PWY-6803	"Glycerophospholipid metabolism";"Anandamide biosynthesis I";"alpha-Linolenic acid metabolism";"Phosphatidylcholine acyl editing"
XP_046415012.1	7	Reactome: R-HSA-5628897;Reactome: R-HSA-210500;KEGG: 00250+3.5.1.2;MetaCyc: PWY-5921;KEGG: 00220+3.5.1.2;KEGG: 00471+3.5.1.2;Reactome: R-HSA-8964539	"TP53 Regulates Metabolic Genes";"Glutamate Neurotransmitter Release Cycle";"Alanine, aspartate and glutamate metabolism";"Glutaminyl-trnagln biosynthesis via transamidation";"Arginine biosynthesis";"D-Glutamine and D-glutamate metabolism";"Glutamate and glutamine metabolism"
XP_046434844.1	11	Reactome: R-HSA-174430;Reactome: R-HSA-6782135;Reactome: R-HSA-5696400;Reactome: R-HSA-5656169;Reactome: R-HSA-68962;Reactome: R-HSA-5651801;Reactome: R-HSA-5685942;Reactome: R-HSA-110314;Reactome: R-HSA-5696397;Reactome: R-HSA-6782210;Reactome: R-HSA-68952	"Telomere C-strand synthesis initiation";"Dual incision in TC-NER";"Dual Incision in GG-NER";"Termination of translesion DNA synthesis";"Activation of the pre-replicative complex";"PCNA-Dependent Long Patch Base Excision Repair";"HDR through Homologous Recombination (HRR)";"Recognition of DNA damage by PCNA-containing replication complex";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Gap-filling DNA repair synthesis and ligation in TC-NER";"DNA replication initiation"
XP_046421733.1	2	Reactome: R-HSA-1221632;Reactome: R-HSA-5601884	"Meiotic synapsis";"PIWI-interacting RNA (piRNA) biogenesis"
XP_046424063.1	8	MetaCyc: PWY-241;MetaCyc: PWY-5789;MetaCyc: PWY-6142;KEGG: 00910+4.2.1.1;MetaCyc: PWY-7115;MetaCyc: PWY-7117;MetaCyc: PWY-5744;MetaCyc: PWY-5743	"C4 photosynthetic carbon assimilation cycle, NADP-ME type";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Nitrogen metabolism";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"C4 photosynthetic carbon assimilation cycle, PEPCK type";"Glyoxylate assimilation";"3-hydroxypropanoate cycle"
XP_046421769.1	3	Reactome: R-HSA-112382;Reactome: R-HSA-674695;Reactome: R-HSA-75955	"Formation of RNA Pol II elongation complex";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Elongation"
XP_046410048.1	5	Reactome: R-HSA-196843;MetaCyc: PWY-5523;MetaCyc: PWY-6168;KEGG: 00740+2.7.1.26;MetaCyc: PWY-7863	"Vitamin B2 (riboflavin) metabolism";"5,6-dimethylbenzimidazole biosynthesis I (aerobic)";"Flavin biosynthesis III (fungi)";"Riboflavin metabolism";"Roseoflavin biosynthesis"
XP_046427318.1	2	Reactome: R-HSA-8856828;Reactome: R-HSA-8856825	"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis"
XP_046424399.1	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
XP_046432974.1	1	Reactome: R-HSA-70221	"Glycogen breakdown (glycogenolysis)"
XP_046424426.1	2	Reactome: R-HSA-203927;Reactome: R-HSA-426486	"MicroRNA (miRNA) biogenesis";"Small interfering RNA (siRNA) biogenesis"
XP_046418443.1	1	Reactome: R-HSA-3238698	"WNT ligand biogenesis and trafficking"
XP_046425471.1	7	Reactome: R-HSA-165159;Reactome: R-HSA-380972;Reactome: R-HSA-5628897;Reactome: R-HSA-9639288;Reactome: R-HSA-8943724;Reactome: R-HSA-1632852;Reactome: R-HSA-166208	"mTOR signalling";"Energy dependent regulation of mTOR by LKB1-AMPK";"TP53 Regulates Metabolic Genes";"Amino acids regulate mTORC1";"Regulation of PTEN gene transcription";"Macroautophagy";"mTORC1-mediated signalling"
XP_046419826.1	5	KEGG: 00250+2.6.1.16;MetaCyc: PWY-6749;MetaCyc: PWY-8013;KEGG: 00520+2.6.1.16;Reactome: R-HSA-446210	"Alanine, aspartate and glutamate metabolism";"CMP-legionaminate biosynthesis I";"UDP-N-acetyl-D-galactosamine biosynthesis III";"Amino sugar and nucleotide sugar metabolism";"Synthesis of UDP-N-acetyl-glucosamine"
XP_046427445.1	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
XP_046431882.1	6	Reactome: R-HSA-9610379;Reactome: R-HSA-162588;Reactome: R-HSA-917729;Reactome: R-HSA-174490;Reactome: R-HSA-9615710;Reactome: R-HSA-8876198	"HCMV Late Events";"Budding and maturation of HIV virion";"Endosomal Sorting Complex Required For Transport (ESCRT)";"Membrane binding and targetting of GAG proteins";"Late endosomal microautophagy";"RAB GEFs exchange GTP for GDP on RABs"
XP_046431083.1	4	Reactome: R-HSA-201722;Reactome: R-HSA-2122947;Reactome: R-HSA-4641265;Reactome: R-HSA-3769402	"Formation of the beta-catenin:TCF transactivating complex";"NOTCH1 Intracellular Domain Regulates Transcription";"Repression of WNT target genes";"Deactivation of the beta-catenin transactivating complex"
XP_046409525.1	7	MetaCyc: PWY-7221;MetaCyc: PWY-6596;MetaCyc: PWY-5695;Reactome: R-HSA-6798695;Reactome: R-HSA-73817;KEGG: 00983+1.1.1.205;KEGG: 00230+1.1.1.205	"Guanosine ribonucleotides de novo biosynthesis";"Adenosine nucleotides degradation I";"Inosine 5'-phosphate degradation";"Neutrophil degranulation";"Purine ribonucleoside monophosphate biosynthesis";"Drug metabolism - other enzymes";"Purine metabolism"
XP_046430712.1	1	Reactome: R-HSA-159236	"Transport of Mature mRNA derived from an Intron-Containing Transcript"
XP_046423450.1	1	Reactome: R-HSA-9617828	"FOXO-mediated transcription of cell cycle genes"
XP_046426211.1	3	Reactome: R-HSA-193648;Reactome: R-HSA-416482;Reactome: R-HSA-194840	"NRAGE signals death through JNK";"G alpha (12/13) signalling events";"Rho GTPase cycle"
XP_046415858.1	5	MetaCyc: PWY-3841;MetaCyc: PWY-6614;Reactome: R-HSA-196757;KEGG: 00670+1.5.1.3;KEGG: 00790+1.5.1.3	"Folate transformations II (plants)";"Tetrahydrofolate biosynthesis";"Metabolism of folate and pterines";"One carbon pool by folate";"Folate biosynthesis"
XP_046428188.1	3	Reactome: R-HSA-5578775;Reactome: R-HSA-418359;Reactome: R-HSA-425561	"Ion homeostasis";"Reduction of cytosolic Ca++ levels";"Sodium/Calcium exchangers"
XP_046417403.1	1	Reactome: R-HSA-432047	"Passive transport by Aquaporins"
XP_046423698.1	4	KEGG: 00513+2.4.1.260;Reactome: R-HSA-4720489;Reactome: R-HSA-446193;KEGG: 00510+2.4.1.260	"Various types of N-glycan biosynthesis";"Defective ALG12 causes ALG12-CDG (CDG-1g)";"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"N-Glycan biosynthesis"
XP_046428263.1	1	Reactome: R-HSA-420499	"Class C/3 (Metabotropic glutamate/pheromone receptors)"
XP_046435890.1	3	Reactome: R-HSA-445095;Reactome: R-HSA-8963901;Reactome: R-HSA-6807878	"Interaction between L1 and Ankyrins";"Chylomicron remodeling";"COPI-mediated anterograde transport"
XP_046432004.1	2	Reactome: R-HSA-72163;Reactome: R-HSA-72165	"mRNA Splicing - Major Pathway";"mRNA Splicing - Minor Pathway"
XP_046409410.1	2	Reactome: R-HSA-375276;Reactome: R-HSA-416476	"Peptide ligand-binding receptors";"G alpha (q) signalling events"
XP_046434261.1	3	Reactome: R-HSA-416482;Reactome: R-HSA-194840;Reactome: R-HSA-193648	"G alpha (12/13) signalling events";"Rho GTPase cycle";"NRAGE signals death through JNK"
XP_046435867.1	2	KEGG: 00520+5.4.2.10;MetaCyc: PWY-6749	"Amino sugar and nucleotide sugar metabolism";"CMP-legionaminate biosynthesis I"
XP_046429568.1	2	Reactome: R-HSA-8951664;Reactome: R-HSA-983168	"Neddylation";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046413773.1	3	Reactome: R-HSA-3000171;Reactome: R-HSA-8874081;Reactome: R-HSA-3000157	"Non-integrin membrane-ECM interactions";"MET activates PTK2 signaling";"Laminin interactions"
XP_046421059.1	4	Reactome: R-HSA-983189;Reactome: R-HSA-2132295;Reactome: R-HSA-5625970;Reactome: R-HSA-6811434	"Kinesins";"MHC class II antigen presentation";"RHO GTPases activate KTN1";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_046426194.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_046420870.1	2	KEGG: 00240+4.2.1.70;MetaCyc: PWY-6019	"Pyrimidine metabolism";"Pseudouridine degradation"
XP_046429576.1	2	Reactome: R-HSA-1369007;Reactome: R-HSA-5683371	"Mitochondrial ABC transporters";"Defective ABCB6 causes isolated colobomatous microphthalmia 7 (MCOPCB7)"
XP_046432246.1	3	Reactome: R-HSA-445355;KEGG: 00230+4.6.1.2;Reactome: R-HSA-392154	"Smooth Muscle Contraction";"Purine metabolism";"Nitric oxide stimulates guanylate cyclase"
XP_046428083.1	4	Reactome: R-HSA-418359;Reactome: R-HSA-5578775;Reactome: R-HSA-1912420;Reactome: R-HSA-936837	"Reduction of cytosolic Ca++ levels";"Ion homeostasis";"Pre-NOTCH Processing in Golgi";"Ion transport by P-type ATPases"
XP_046410971.1	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
XP_046428428.1	7	KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1	"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Thermogenesis";"Human cytomegalovirus infection";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Relaxin signaling pathway"
XP_046428504.1	3	Reactome: R-HSA-212436;Reactome: R-HSA-1989781;Reactome: R-HSA-381340	"Generic Transcription Pathway";"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation"
XP_046423911.1	1	Reactome: R-HSA-162658	"Golgi Cisternae Pericentriolar Stack Reorganization"
XP_046417492.1	2	Reactome: R-HSA-418890;Reactome: R-HSA-3295583	"Role of second messengers in netrin-1 signaling";"TRP channels"
XP_046429542.1	1	Reactome: R-HSA-977443	"GABA receptor activation"
XP_046419255.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046413260.1	3	MetaCyc: PWY-7159;Reactome: R-HSA-189451;KEGG: 00860+1.3.3.4	"3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent)";"Heme biosynthesis";"Porphyrin and chlorophyll metabolism"
XP_046410464.1	5	KEGG: 00480+6.3.2.3;Reactome: R-HSA-5579006;KEGG: 00270+6.3.2.3;Reactome: R-HSA-174403;MetaCyc: PWY-8043	"Glutathione metabolism";"Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)";"Cysteine and methionine metabolism";"Glutathione synthesis and recycling";"Ophthalmate biosynthesis"
XP_046416357.1	1	Reactome: R-HSA-5693568	"Resolution of D-loop Structures through Holliday Junction Intermediates"
XP_046413489.1	11	Reactome: R-HSA-432040;Reactome: R-HSA-418594;KEGG: 00230+4.6.1.1;Reactome: R-HSA-170670;Reactome: R-HSA-163615;Reactome: R-HSA-5610787;Reactome: R-HSA-163359;Reactome: R-HSA-164378;Reactome: R-HSA-418597;Reactome: R-HSA-170660;Reactome: R-HSA-418555	"Vasopressin regulates renal water homeostasis via Aquaporins";"G alpha (i) signalling events";"Purine metabolism";"Adenylate cyclase inhibitory pathway";"PKA activation";"Hedgehog 'off' state";"Glucagon signaling in metabolic regulation";"PKA activation in glucagon signalling";"G alpha (z) signalling events";"Adenylate cyclase activating pathway";"G alpha (s) signalling events"
XP_046416143.1	10	MetaCyc: PWY-6453;MetaCyc: PWY-8051;MetaCyc: PWY-8055;MetaCyc: PWY-5667;KEGG: 00564+2.3.1.15;KEGG: 00561+2.3.1.15;Reactome: R-HSA-1483166;MetaCyc: PWY-7411;MetaCyc: PWY-7587;MetaCyc: PWY-8053	"Stigma estolide biosynthesis";"Anandamide biosynthesis I";"Palmitoyl ethanolamide biosynthesis";"CDP-diacylglycerol biosynthesis I";"Glycerophospholipid metabolism";"Glycerolipid metabolism";"Synthesis of PA";"Phosphatidate biosynthesis (yeast)";"Oleate biosynthesis III (cyanobacteria)";"Anandamide biosynthesis II"
XP_046409503.1	1	MetaCyc: PWY-6938	"NADH repair"
XP_046417548.1	2	Reactome: R-HSA-6798695;Reactome: R-HSA-936837	"Neutrophil degranulation";"Ion transport by P-type ATPases"
XP_046419801.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046412837.1	2	Reactome: R-HSA-5620924;Reactome: R-HSA-5610787	"Intraflagellar transport";"Hedgehog 'off' state"
XP_046430674.1	1	Reactome: R-HSA-189451	"Heme biosynthesis"
XP_046426086.1	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
XP_046420687.1	2	KEGG: 00970+6.1.1.20;Reactome: R-HSA-379716	"Aminoacyl-tRNA biosynthesis";"Cytosolic tRNA aminoacylation"
XP_046435751.1	7	Reactome: R-HSA-389661;Reactome: R-HSA-5362517;Reactome: R-HSA-204174;KEGG: 00020+1.2.4.1;KEGG: 00010+1.2.4.1;KEGG: 00620+1.2.4.1;Reactome: R-HSA-70268	"Glyoxylate metabolism and glycine degradation";"Signaling by Retinoic Acid";"Regulation of pyruvate dehydrogenase (PDH) complex";"Citrate cycle (TCA cycle)";"Glycolysis / Gluconeogenesis";"Pyruvate metabolism";"Pyruvate metabolism"
XP_046413190.1	8	KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05163+2.7.11.1;Reactome: R-HSA-975957;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1	"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Human cytomegalovirus infection";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Relaxin signaling pathway";"Thermogenesis";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection"
XP_046425743.1	11	Reactome: R-HSA-2132295;Reactome: R-HSA-380284;Reactome: R-HSA-6811436;Reactome: R-HSA-380259;Reactome: R-HSA-380320;Reactome: R-HSA-2565942;Reactome: R-HSA-5620912;Reactome: R-HSA-8854518;Reactome: R-HSA-6807878;Reactome: R-HSA-3371497;Reactome: R-HSA-380270	"MHC class II antigen presentation";"Loss of proteins required for interphase microtubule organization from the centrosome";"COPI-independent Golgi-to-ER retrograde traffic";"Loss of Nlp from mitotic centrosomes";"Recruitment of NuMA to mitotic centrosomes";"Regulation of PLK1 Activity at G2/M Transition";"Anchoring of the basal body to the plasma membrane";"AURKA Activation by TPX2";"COPI-mediated anterograde transport";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Recruitment of mitotic centrosome proteins and complexes"
XP_046430835.1	2	Reactome: R-HSA-1236394;Reactome: R-HSA-977443	"Signaling by ERBB4";"GABA receptor activation"
XP_046414738.1	1	Reactome: R-HSA-432720	"Lysosome Vesicle Biogenesis"
XP_046410704.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_046410992.1	5	Reactome: R-HSA-1912399;Reactome: R-HSA-5083630;Reactome: R-HSA-1912408;Reactome: R-HSA-350054;Reactome: R-HSA-1912420	"Pre-NOTCH Processing in the Endoplasmic Reticulum";"Defective LFNG causes SCDO3";"Pre-NOTCH Transcription and Translation";"Notch-HLH transcription pathway";"Pre-NOTCH Processing in Golgi"
XP_046410969.1	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
XP_046424800.1	12	KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;Reactome: R-HSA-5628897;Reactome: R-HSA-6804756;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;Reactome: R-HSA-9619483;Reactome: R-HSA-380972;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;Reactome: R-HSA-1632852;KEGG: 04714+2.7.11.1	"mTOR signaling pathway";"PI3K-Akt signaling pathway";"TP53 Regulates Metabolic Genes";"Regulation of TP53 Activity through Phosphorylation";"Relaxin signaling pathway";"Human cytomegalovirus infection";"Activation of AMPK downstream of NMDARs";"Energy dependent regulation of mTOR by LKB1-AMPK";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Macroautophagy";"Thermogenesis"
XP_046416953.1	1	Reactome: R-HSA-9037629	"Lewis blood group biosynthesis"
XP_046422712.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_046417766.1	5	Reactome: R-HSA-72163;Reactome: R-HSA-159236;Reactome: R-HSA-72187;Reactome: R-HSA-73856;Reactome: R-HSA-72165	"mRNA Splicing - Major Pathway";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"mRNA 3'-end processing";"RNA Polymerase II Transcription Termination";"mRNA Splicing - Minor Pathway"
XP_046424400.1	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
XP_046420008.1	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
XP_046427537.1	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_046436108.1	2	Reactome: R-HSA-379726;KEGG: 00970+6.1.1.2	"Mitochondrial tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis"
XP_046435094.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_046420651.1	2	Reactome: R-HSA-6804115;Reactome: R-HSA-429947	"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Deadenylation of mRNA"
XP_046428376.1	2	KEGG: 00230+2.7.4.8;MetaCyc: PWY-7221	"Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis"
XP_046411832.1	8	MetaCyc: PWY-6901;KEGG: 00010+1.1.1.27;KEGG: 00640+1.1.1.27;MetaCyc: PWY-8086;Reactome: R-HSA-70268;MetaCyc: PWY-5481;KEGG: 00270+1.1.1.27;KEGG: 00620+1.1.1.27	"Superpathway of glucose and xylose degradation";"Glycolysis / Gluconeogenesis";"Propanoate metabolism";"(S)-lactate fermentation to propanoate, acetate and hydrogen";"Pyruvate metabolism";"Pyruvate fermentation to (S)-lactate";"Cysteine and methionine metabolism";"Pyruvate metabolism"
XP_046427625.1	2	KEGG: 00500+3.2.1.28;Reactome: R-HSA-189085	"Starch and sucrose metabolism";"Digestion of dietary carbohydrate"
XP_046411762.1	4	Reactome: R-HSA-77387;Reactome: R-HSA-1222556;Reactome: R-HSA-917977;Reactome: R-HSA-983712	"Insulin receptor recycling";"ROS and RNS production in phagocytes";"Transferrin endocytosis and recycling";"Ion channel transport"
XP_046435437.1	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
XP_046432104.1	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
XP_046424932.1	1	Reactome: R-HSA-432720	"Lysosome Vesicle Biogenesis"
XP_046415913.1	1	Reactome: R-HSA-389957	"Prefoldin mediated transfer of substrate to CCT/TriC"
XP_046410380.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_046425313.1	1	Reactome: R-HSA-216083	"Integrin cell surface interactions"
XP_046423324.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046431867.1	8	Reactome: R-HSA-432720;Reactome: R-HSA-3928665;Reactome: R-HSA-5140745;Reactome: R-HSA-8856825;Reactome: R-HSA-5099900;Reactome: R-HSA-190873;Reactome: R-HSA-196025;Reactome: R-HSA-8856828	"Lysosome Vesicle Biogenesis";"EPH-ephrin mediated repulsion of cells";"WNT5A-dependent internalization of FZD2, FZD5 and ROR2";"Cargo recognition for clathrin-mediated endocytosis";"WNT5A-dependent internalization of FZD4";"Gap junction degradation";"Formation of annular gap junctions";"Clathrin-mediated endocytosis"
XP_046420800.1	10	Reactome: R-HSA-1445148;Reactome: R-HSA-380972;Reactome: R-HSA-2151209;Reactome: R-HSA-9619483;Reactome: R-HSA-1632852;Reactome: R-HSA-9613354;Reactome: R-HSA-5628897;Reactome: R-HSA-200425;Reactome: R-HSA-163680;Reactome: R-HSA-6804756	"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Energy dependent regulation of mTOR by LKB1-AMPK";"Activation of PPARGC1A (PGC-1alpha) by phosphorylation";"Activation of AMPK downstream of NMDARs";"Macroautophagy";"Lipophagy";"TP53 Regulates Metabolic Genes";"Carnitine metabolism";"AMPK inhibits chREBP transcriptional activation activity";"Regulation of TP53 Activity through Phosphorylation"
XP_046414890.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_046434317.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_046424894.1	14	Reactome: R-HSA-9648025;Reactome: R-HSA-2565942;Reactome: R-HSA-141444;Reactome: R-HSA-380320;Reactome: R-HSA-68877;Reactome: R-HSA-380259;Reactome: R-HSA-6811436;Reactome: R-HSA-2467813;Reactome: R-HSA-380284;Reactome: R-HSA-380270;Reactome: R-HSA-8854518;Reactome: R-HSA-5663220;Reactome: R-HSA-5620912;Reactome: R-HSA-2500257	"EML4 and NUDC in mitotic spindle formation";"Regulation of PLK1 Activity at G2/M Transition";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Recruitment of NuMA to mitotic centrosomes";"Mitotic Prometaphase";"Loss of Nlp from mitotic centrosomes";"COPI-independent Golgi-to-ER retrograde traffic";"Separation of Sister Chromatids";"Loss of proteins required for interphase microtubule organization from the centrosome";"Recruitment of mitotic centrosome proteins and complexes";"AURKA Activation by TPX2";"RHO GTPases Activate Formins";"Anchoring of the basal body to the plasma membrane";"Resolution of Sister Chromatid Cohesion"
XP_046432009.1	8	KEGG: 00195+7.1.2.2;Reactome: R-HSA-9639288;Reactome: R-HSA-77387;KEGG: 00190+7.1.2.2;Reactome: R-HSA-983712;MetaCyc: PWY-7980;Reactome: R-HSA-917977;Reactome: R-HSA-1222556	"Photosynthesis";"Amino acids regulate mTORC1";"Insulin receptor recycling";"Oxidative phosphorylation";"Ion channel transport";"ATP biosynthesis";"Transferrin endocytosis and recycling";"ROS and RNS production in phagocytes"
XP_046429918.1	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
XP_046428812.1	29	Reactome: R-HSA-167160;Reactome: R-HSA-73762;Reactome: R-HSA-6782135;Reactome: R-HSA-73779;Reactome: R-HSA-167158;Reactome: R-HSA-5696400;Reactome: R-HSA-6781827;Reactome: R-HSA-113418;Reactome: R-HSA-6782210;Reactome: R-HSA-167162;Reactome: R-HSA-167246;Reactome: R-HSA-6781823;Reactome: R-HSA-427413;Reactome: R-HSA-75953;Reactome: R-HSA-5696395;Reactome: R-HSA-167161;Reactome: R-HSA-167152;Reactome: R-HSA-73772;Reactome: R-HSA-77075;Reactome: R-HSA-6796648;Reactome: R-HSA-167200;Reactome: R-HSA-73776;Reactome: R-HSA-72086;Reactome: R-HSA-674695;Reactome: R-HSA-112382;Reactome: R-HSA-73863;Reactome: R-HSA-75955;Reactome: R-HSA-167172;Reactome: R-HSA-76042	"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"RNA Polymerase I Transcription Initiation";"Dual incision in TC-NER";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Formation of the HIV-1 Early Elongation Complex";"Dual Incision in GG-NER";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Formation of the Early Elongation Complex";"Gap-filling DNA repair synthesis and ligation in TC-NER";"RNA Polymerase II HIV Promoter Escape";"Tat-mediated elongation of the HIV-1 transcript";"Formation of TC-NER Pre-Incision Complex";"NoRC negatively regulates rRNA expression";"RNA Polymerase II Transcription Initiation";"Formation of Incision Complex in GG-NER";"HIV Transcription Initiation";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Polymerase I Promoter Escape";"RNA Pol II CTD phosphorylation and interaction with CE";"TP53 Regulates Transcription of DNA Repair Genes";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Polymerase II Promoter Escape";"mRNA Capping";"RNA Polymerase II Pre-transcription Events";"Formation of RNA Pol II elongation complex";"RNA Polymerase I Transcription Termination";"RNA Polymerase II Transcription Elongation";"Transcription of the HIV genome";"RNA Polymerase II Transcription Initiation And Promoter Clearance"
XP_046427735.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_046420962.1	4	KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16;Reactome: R-HSA-6807505;KEGG: 05235+3.1.3.16	"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation";"RNA polymerase II transcribes snRNA genes";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
XP_046432198.1	4	Reactome: R-HSA-445095;Reactome: R-HSA-6807878;Reactome: R-HSA-375165;Reactome: R-HSA-5673001	"Interaction between L1 and Ankyrins";"COPI-mediated anterograde transport";"NCAM signaling for neurite out-growth";"RAF/MAP kinase cascade"
XP_046409630.1	10	Reactome: R-HSA-111459;Reactome: R-HSA-9627069;Reactome: R-HSA-111457;Reactome: R-HSA-3299685;Reactome: R-HSA-2151201;Reactome: R-HSA-111463;Reactome: R-HSA-111464;Reactome: R-HSA-111458;Reactome: R-HSA-5628897;Reactome: R-HSA-611105	"Activation of caspases through apoptosome-mediated cleavage";"Regulation of the apoptosome activity";"Release of apoptotic factors from the mitochondria";"Detoxification of Reactive Oxygen Species";"Transcriptional activation of mitochondrial biogenesis";"SMAC (DIABLO) binds to IAPs";"SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes";"Formation of apoptosome";"TP53 Regulates Metabolic Genes";"Respiratory electron transport"
XP_046412952.1	1	Reactome: R-HSA-2299718	"Condensation of Prophase Chromosomes"
XP_046424080.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046430424.1	1	Reactome: R-HSA-5689901	"Metalloprotease DUBs"
XP_046419894.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046416255.1	4	Reactome: R-HSA-2132295;Reactome: R-HSA-3371497;Reactome: R-HSA-6811436;Reactome: R-HSA-6807878	"MHC class II antigen presentation";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-independent Golgi-to-ER retrograde traffic";"COPI-mediated anterograde transport"
XP_046435369.1	2	Reactome: R-HSA-8856825;Reactome: R-HSA-8856828	"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis"
XP_046428710.1	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
XP_046425056.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_046428160.1	2	Reactome: R-HSA-195253;Reactome: R-HSA-5689896	"Degradation of beta-catenin by the destruction complex";"Ovarian tumor domain proteases"
XP_046410512.1	6	KEGG: 00561+2.7.1.107;MetaCyc: PWY-7039;MetaCyc: PWY-7817;KEGG: 00564+2.7.1.107;Reactome: R-HSA-114508;KEGG: 04070+2.7.1.107	"Glycerolipid metabolism";"Phosphatidate metabolism, as a signaling molecule";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Glycerophospholipid metabolism";"Effects of PIP2 hydrolysis";"Phosphatidylinositol signaling system"
XP_046423791.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_046434378.1	1	Reactome: R-HSA-216083	"Integrin cell surface interactions"
XP_046434656.1	3	Reactome: R-HSA-72187;Reactome: R-HSA-159236;Reactome: R-HSA-73856	"mRNA 3'-end processing";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"RNA Polymerase II Transcription Termination"
XP_046432693.1	2	Reactome: R-HSA-445095;Reactome: R-HSA-5576892	"Interaction between L1 and Ankyrins";"Phase 0 - rapid depolarisation"
XP_046416915.1	14	KEGG: 00591+3.1.1.4;MetaCyc: PWY-7417;MetaCyc: PWY-7409;MetaCyc: PWY-7416;MetaCyc: PWY-8053;KEGG: 00590+3.1.1.4;Reactome: R-HSA-975634;KEGG: 00592+3.1.1.4;MetaCyc: PWY-7783;MetaCyc: PWY-8051;KEGG: 00564+3.1.1.4+3.1.1.5;KEGG: 00565+3.1.1.4;Reactome: R-HSA-1482788;MetaCyc: PWY-6803	"Linoleic acid metabolism";"Phospholipid remodeling (phosphatidate, yeast)";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Anandamide biosynthesis II";"Arachidonic acid metabolism";"Retinoid metabolism and transport";"alpha-Linolenic acid metabolism";"Plasmalogen degradation";"Anandamide biosynthesis I";"Glycerophospholipid metabolism";"Ether lipid metabolism";"Acyl chain remodelling of PC";"Phosphatidylcholine acyl editing"
XP_046410740.1	4	Reactome: R-HSA-5576893;Reactome: R-HSA-5576892;Reactome: R-HSA-419037;Reactome: R-HSA-112308	"Phase 2 - plateau phase";"Phase 0 - rapid depolarisation";"NCAM1 interactions";"Presynaptic depolarization and calcium channel opening"
XP_046423759.1	2	Reactome: R-HSA-8949613;Reactome: R-HSA-163210	"Cristae formation";"Formation of ATP by chemiosmotic coupling"
XP_046428979.1	2	Reactome: R-HSA-9033241;Reactome: R-HSA-8866654	"Peroxisomal protein import";"E3 ubiquitin ligases ubiquitinate target proteins"
XP_046434985.1	4	Reactome: R-HSA-3214815;Reactome: R-HSA-8943724;Reactome: R-HSA-427389;Reactome: R-HSA-73762	"HDACs deacetylate histones";"Regulation of PTEN gene transcription";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"RNA Polymerase I Transcription Initiation"
XP_046422050.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-5628897	"Respiratory electron transport";"TP53 Regulates Metabolic Genes"
XP_046434863.1	13	Reactome: R-HSA-72689;Reactome: R-HSA-9633012;Reactome: R-HSA-192823;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-2408557;Reactome: R-HSA-72706;Reactome: R-HSA-1799339;Reactome: R-HSA-975957;Reactome: R-HSA-6791226;Reactome: R-HSA-975956;Reactome: R-HSA-156902;Reactome: R-HSA-72764	"Formation of a pool of free 40S subunits";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Viral mRNA Translation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Selenocysteine synthesis";"GTP hydrolysis and joining of the 60S ribosomal subunit";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Peptide chain elongation";"Eukaryotic Translation Termination"
XP_046425366.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_046427072.1	11	Reactome: R-HSA-418594;Reactome: R-HSA-432040;Reactome: R-HSA-5610787;Reactome: R-HSA-163615;Reactome: R-HSA-170670;KEGG: 00230+4.6.1.1;Reactome: R-HSA-164378;Reactome: R-HSA-163359;Reactome: R-HSA-418555;Reactome: R-HSA-170660;Reactome: R-HSA-418597	"G alpha (i) signalling events";"Vasopressin regulates renal water homeostasis via Aquaporins";"Hedgehog 'off' state";"PKA activation";"Adenylate cyclase inhibitory pathway";"Purine metabolism";"PKA activation in glucagon signalling";"Glucagon signaling in metabolic regulation";"G alpha (s) signalling events";"Adenylate cyclase activating pathway";"G alpha (z) signalling events"
XP_046418655.1	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276	"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination"
XP_046413493.1	11	Reactome: R-HSA-170670;KEGG: 00230+4.6.1.1;Reactome: R-HSA-5610787;Reactome: R-HSA-163615;Reactome: R-HSA-432040;Reactome: R-HSA-418594;Reactome: R-HSA-170660;Reactome: R-HSA-418597;Reactome: R-HSA-418555;Reactome: R-HSA-163359;Reactome: R-HSA-164378	"Adenylate cyclase inhibitory pathway";"Purine metabolism";"Hedgehog 'off' state";"PKA activation";"Vasopressin regulates renal water homeostasis via Aquaporins";"G alpha (i) signalling events";"Adenylate cyclase activating pathway";"G alpha (z) signalling events";"G alpha (s) signalling events";"Glucagon signaling in metabolic regulation";"PKA activation in glucagon signalling"
XP_046410326.1	1	Reactome: R-HSA-432722	"Golgi Associated Vesicle Biogenesis"
XP_046414115.1	1	Reactome: R-HSA-6811440	"Retrograde transport at the Trans-Golgi-Network"
XP_046429464.1	1	Reactome: R-HSA-419771	"Opsins"
XP_046430199.1	2	Reactome: R-HSA-2682334;Reactome: R-HSA-3928665	"EPH-Ephrin signaling";"EPH-ephrin mediated repulsion of cells"
XP_046429716.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_046430469.1	4	Reactome: R-HSA-3769402;Reactome: R-HSA-201722;Reactome: R-HSA-2122947;Reactome: R-HSA-4641265	"Deactivation of the beta-catenin transactivating complex";"Formation of the beta-catenin:TCF transactivating complex";"NOTCH1 Intracellular Domain Regulates Transcription";"Repression of WNT target genes"
XP_046410286.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046417744.1	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
XP_046424392.1	1	Reactome: R-HSA-2393930	"Phosphate bond hydrolysis by NUDT proteins"
XP_046409950.1	2	Reactome: R-HSA-8876198;Reactome: R-HSA-204005	"RAB GEFs exchange GTP for GDP on RABs";"COPII-mediated vesicle transport"
XP_046432834.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_046430677.1	3	MetaCyc: PWY-3961;Reactome: R-HSA-196783;KEGG: 00770+2.7.1.33	"Phosphopantothenate biosynthesis II";"Coenzyme A biosynthesis";"Pantothenate and CoA biosynthesis"
XP_046429936.1	5	KEGG: 00514+2.4.1.109;MetaCyc: PWY-7921;MetaCyc: PWY-7922;KEGG: 00515+2.4.1.109;MetaCyc: PWY-7979	"Other types of O-glycan biosynthesis";"Protein O-mannosylation I (yeast)";"Protein O-mannosylation II (mammals, core M1 and core M2)";"Mannose type O-glycan biosynthesis";"Protein O-mannosylation III (mammals, core M3)"
XP_046431970.1	4	Reactome: R-HSA-9010553;Reactome: R-HSA-975957;Reactome: R-HSA-72764;Reactome: R-HSA-975956	"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"
XP_046430682.1	3	KEGG: 00770+2.7.1.33;Reactome: R-HSA-196783;MetaCyc: PWY-3961	"Pantothenate and CoA biosynthesis";"Coenzyme A biosynthesis";"Phosphopantothenate biosynthesis II"
XP_046419591.1	3	MetaCyc: PWY-6317;KEGG: 00052+5.1.3.3;KEGG: 00010+5.1.3.3	"D-galactose degradation I (Leloir pathway)";"Galactose metabolism";"Glycolysis / Gluconeogenesis"
XP_046412156.1	1	Reactome: R-HSA-6814848	"Glycerophospholipid catabolism"
XP_046425514.1	2	KEGG: 00520+2.4.1.16;MetaCyc: PWY-6981	"Amino sugar and nucleotide sugar metabolism";"Chitin biosynthesis"
XP_046435195.1	1	Reactome: R-HSA-2465910	"MASTL Facilitates Mitotic Progression"
XP_046434023.1	4	KEGG: 00564+3.1.1.32;MetaCyc: PWY-8051;KEGG: 00592+3.1.1.32;MetaCyc: PWY-6803	"Glycerophospholipid metabolism";"Anandamide biosynthesis I";"alpha-Linolenic acid metabolism";"Phosphatidylcholine acyl editing"
XP_046429689.1	1	Reactome: R-HSA-388844	"Receptor-type tyrosine-protein phosphatases"
XP_046411229.1	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046422631.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
XP_046421025.1	6	KEGG: 00073+1.2.1.84;MetaCyc: PWY-7656;Reactome: R-HSA-9640463;MetaCyc: PWY-6733;MetaCyc: PWY-7782;MetaCyc: PWY-5884	"Cutin, suberine and wax biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Wax biosynthesis";"Sporopollenin precursors biosynthesis";"Plasmalogen biosynthesis";"Wax esters biosynthesis I"
XP_046417352.1	8	Reactome: R-HSA-5628897;Reactome: R-HSA-9613354;Reactome: R-HSA-6804756;Reactome: R-HSA-380972;Reactome: R-HSA-1445148;Reactome: R-HSA-9619483;Reactome: R-HSA-2151209;Reactome: R-HSA-1632852	"TP53 Regulates Metabolic Genes";"Lipophagy";"Regulation of TP53 Activity through Phosphorylation";"Energy dependent regulation of mTOR by LKB1-AMPK";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Activation of AMPK downstream of NMDARs";"Activation of PPARGC1A (PGC-1alpha) by phosphorylation";"Macroautophagy"
XP_046413248.1	1	Reactome: R-HSA-6811440	"Retrograde transport at the Trans-Golgi-Network"
XP_046419129.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_046416186.1	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
XP_046424484.1	6	KEGG: 00073+1.2.1.84;MetaCyc: PWY-7656;Reactome: R-HSA-9640463;MetaCyc: PWY-6733;MetaCyc: PWY-5884;MetaCyc: PWY-7782	"Cutin, suberine and wax biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Wax biosynthesis";"Sporopollenin precursors biosynthesis";"Wax esters biosynthesis I";"Plasmalogen biosynthesis"
XP_046431483.1	3	Reactome: R-HSA-2029482;Reactome: R-HSA-5663213;Reactome: R-HSA-4420097	"Regulation of actin dynamics for phagocytic cup formation";"RHO GTPases Activate WASPs and WAVEs";"VEGFA-VEGFR2 Pathway"
XP_046424916.1	3	Reactome: R-HSA-983168;MetaCyc: PWY-7511;Reactome: R-HSA-6798695	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination";"Neutrophil degranulation"
XP_046434687.1	3	KEGG: 00230+3.5.4.6;Reactome: R-HSA-74217;MetaCyc: PWY-6596	"Purine metabolism";"Purine salvage";"Adenosine nucleotides degradation I"
XP_046412057.1	3	Reactome: R-HSA-390471;Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Association of TriC/CCT with target proteins during biosynthesis";"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_046416832.1	14	MetaCyc: PWY-7409;MetaCyc: PWY-7416;MetaCyc: PWY-8053;KEGG: 00591+3.1.1.4;MetaCyc: PWY-7417;MetaCyc: PWY-8051;KEGG: 00564+3.1.1.4+3.1.1.5;KEGG: 00565+3.1.1.4;Reactome: R-HSA-1482788;MetaCyc: PWY-6803;KEGG: 00590+3.1.1.4;Reactome: R-HSA-975634;KEGG: 00592+3.1.1.4;MetaCyc: PWY-7783	"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Anandamide biosynthesis II";"Linoleic acid metabolism";"Phospholipid remodeling (phosphatidate, yeast)";"Anandamide biosynthesis I";"Glycerophospholipid metabolism";"Ether lipid metabolism";"Acyl chain remodelling of PC";"Phosphatidylcholine acyl editing";"Arachidonic acid metabolism";"Retinoid metabolism and transport";"alpha-Linolenic acid metabolism";"Plasmalogen degradation"
XP_046412387.1	1	Reactome: R-HSA-2142789	"Ubiquinol biosynthesis"
XP_046433148.1	1	Reactome: R-HSA-1632852	"Macroautophagy"
XP_046420163.1	10	MetaCyc: PWY-7003;Reactome: R-HSA-70171;MetaCyc: PWY-5484;KEGG: 00710+2.7.2.3;MetaCyc: PWY-1042;KEGG: 00010+2.7.2.3;MetaCyc: PWY-8004;Reactome: R-HSA-70263;MetaCyc: PWY-6901;MetaCyc: PWY-6886	"Glycerol degradation to butanol";"Glycolysis";"Glycolysis II (from fructose 6-phosphate)";"Carbon fixation in photosynthetic organisms";"Glycolysis IV (plant cytosol)";"Glycolysis / Gluconeogenesis";"Entner-Doudoroff pathway I";"Gluconeogenesis";"Superpathway of glucose and xylose degradation";"1-butanol autotrophic biosynthesis (engineered)"
XP_046425042.1	10	Reactome: R-HSA-2160916;KEGG: 00600+3.2.1.23;Reactome: R-HSA-6798695;KEGG: 00604+3.2.1.23;MetaCyc: PWY-6807;KEGG: 00511+3.2.1.23;KEGG: 00531+3.2.1.23;Reactome: R-HSA-2024096;KEGG: 00052+3.2.1.23;Reactome: R-HSA-2206292	"Hyaluronan uptake and degradation";"Sphingolipid metabolism";"Neutrophil degranulation";"Glycosphingolipid biosynthesis - ganglio series";"Xyloglucan degradation II (exoglucanase)";"Other glycan degradation";"Glycosaminoglycan degradation";"HS-GAG degradation";"Galactose metabolism";"MPS VII - Sly syndrome"
XP_046435464.1	1	Reactome: R-HSA-1660661	"Sphingolipid de novo biosynthesis"
XP_046419620.1	11	Reactome: R-HSA-1368108;Reactome: R-HSA-2426168;Reactome: R-HSA-2151201;Reactome: R-HSA-381340;Reactome: R-HSA-383280;Reactome: R-HSA-212436;Reactome: R-HSA-400253;Reactome: R-HSA-9018519;Reactome: R-HSA-1368082;Reactome: R-HSA-400206;Reactome: R-HSA-1989781	"BMAL1:CLOCK,NPAS2 activates circadian gene expression";"Activation of gene expression by SREBF (SREBP)";"Transcriptional activation of mitochondrial biogenesis";"Transcriptional regulation of white adipocyte differentiation";"Nuclear Receptor transcription pathway";"Generic Transcription Pathway";"Circadian Clock";"Estrogen-dependent gene expression";"RORA activates gene expression";"Regulation of lipid metabolism by PPARalpha";"PPARA activates gene expression"
XP_046409562.1	4	MetaCyc: PWY-6557;Reactome: R-HSA-1971475;KEGG: 00534+2.4.2.26;KEGG: 00532+2.4.2.26	"Glycosaminoglycan-protein linkage region biosynthesis";"A tetrasaccharide linker sequence is required for GAG synthesis";"Glycosaminoglycan biosynthesis - heparan sulfate / heparin";"Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate"
XP_046417683.1	1	KEGG: 00970+6.1.1.3	"Aminoacyl-tRNA biosynthesis"
XP_046427991.1	3	Reactome: R-HSA-194840;Reactome: R-HSA-416482;Reactome: R-HSA-193648	"Rho GTPase cycle";"G alpha (12/13) signalling events";"NRAGE signals death through JNK"
XP_046412167.1	3	Reactome: R-HSA-196757;MetaCyc: PWY-2161;KEGG: 00790+6.3.2.17	"Metabolism of folate and pterines";"Folate polyglutamylation";"Folate biosynthesis"
XP_046427501.1	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_046431255.1	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
XP_046417325.1	2	MetaCyc: PWY-7802;MetaCyc: PWY-7799	"N-end rule pathway II (prokaryotic)";"Arg/N-end rule pathway (eukaryotic)"
XP_046417536.1	1	Reactome: R-HSA-186797	"Signaling by PDGF"
XP_046424586.1	7	Reactome: R-HSA-8854214;Reactome: R-HSA-165181;Reactome: R-HSA-198323;Reactome: R-HSA-5628897;Reactome: R-HSA-380972;Reactome: R-HSA-5674400;Reactome: R-HSA-1632852	"TBC/RABGAPs";"Inhibition of TSC complex formation by PKB";"AKT phosphorylates targets in the cytosol";"TP53 Regulates Metabolic Genes";"Energy dependent regulation of mTOR by LKB1-AMPK";"Constitutive Signaling by AKT1 E17K in Cancer";"Macroautophagy"
XP_046434425.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_046432561.1	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
XP_046419803.1	1	KEGG: 00760+2.3.1.286	"Nicotinate and nicotinamide metabolism"
XP_046428426.1	7	KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04926+2.7.11.1	"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Thermogenesis";"Human cytomegalovirus infection";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Relaxin signaling pathway"
XP_046422771.1	4	MetaCyc: PWY-7822;MetaCyc: PWY-6855;MetaCyc: PWY-6902;KEGG: 00520+3.2.1.14	"Chitin degradation III (Serratia)";"Chitin degradation I (archaea)";"Chitin degradation II (Vibrio)";"Amino sugar and nucleotide sugar metabolism"
XP_046422250.1	3	Reactome: R-HSA-76066;Reactome: R-HSA-76061;Reactome: R-HSA-749476	"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Abortive And Retractive Initiation"
XP_046414199.1	1	Reactome: R-HSA-5620912	"Anchoring of the basal body to the plasma membrane"
XP_046429120.1	2	Reactome: R-HSA-72163;Reactome: R-HSA-6807505	"mRNA Splicing - Major Pathway";"RNA polymerase II transcribes snRNA genes"
XP_046423212.1	1	Reactome: R-HSA-418886	"Netrin mediated repulsion signals"
XP_046419735.1	3	KEGG: 00480+1.1.1.44;Reactome: R-HSA-71336;KEGG: 00030+1.1.1.44	"Glutathione metabolism";"Pentose phosphate pathway";"Pentose phosphate pathway"
XP_046431117.1	2	Reactome: R-HSA-445355;Reactome: R-HSA-390522	"Smooth Muscle Contraction";"Striated Muscle Contraction"
XP_046422532.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_046416175.1	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
XP_046425771.1	1	Reactome: R-HSA-211981	"Xenobiotics"
XP_046428355.1	1	Reactome: R-HSA-5389840	"Mitochondrial translation elongation"
XP_046412195.1	1	Reactome: R-HSA-8949613	"Cristae formation"
XP_046424263.1	2	Reactome: R-HSA-6811434;Reactome: R-HSA-6807878	"COPI-dependent Golgi-to-ER retrograde traffic";"COPI-mediated anterograde transport"
XP_046412142.1	1	Reactome: R-HSA-9616222	"Transcriptional regulation of granulopoiesis"
XP_046412704.1	9	Reactome: R-HSA-9630222;Reactome: R-HSA-110329;Reactome: R-HSA-110328;Reactome: R-HSA-9608287;Reactome: R-HSA-9608290;Reactome: R-HSA-110331;Reactome: R-HSA-110357;Reactome: R-HSA-110330;Reactome: R-HSA-9630221	"Defective NTHL1 substrate binding";"Cleavage of the damaged pyrimidine";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"Defective MUTYH substrate binding";"Defective MUTYH substrate processing";"Cleavage of the damaged purine";"Displacement of DNA glycosylase by APEX1";"Recognition and association of DNA glycosylase with site containing an affected purine";"Defective NTHL1 substrate processing"
XP_046428811.1	3	KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16	"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
XP_046430007.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046427801.1	1	Reactome: R-HSA-196819	"Vitamin B1 (thiamin) metabolism"
XP_046425449.1	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286	"Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation"
XP_046421953.1	2	Reactome: R-HSA-1296052;Reactome: R-HSA-418457	"Ca2+ activated K+ channels";"cGMP effects"
XP_046412703.1	9	Reactome: R-HSA-9608290;Reactome: R-HSA-110329;Reactome: R-HSA-110328;Reactome: R-HSA-9608287;Reactome: R-HSA-9630222;Reactome: R-HSA-110330;Reactome: R-HSA-110357;Reactome: R-HSA-110331;Reactome: R-HSA-9630221	"Defective MUTYH substrate processing";"Cleavage of the damaged pyrimidine";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"Defective MUTYH substrate binding";"Defective NTHL1 substrate binding";"Recognition and association of DNA glycosylase with site containing an affected purine";"Displacement of DNA glycosylase by APEX1";"Cleavage of the damaged purine";"Defective NTHL1 substrate processing"
XP_046430711.1	16	Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-72706;Reactome: R-HSA-2408557;Reactome: R-HSA-6791226;Reactome: R-HSA-72702;Reactome: R-HSA-975956;Reactome: R-HSA-192823;Reactome: R-HSA-72689;Reactome: R-HSA-1799339;Reactome: R-HSA-72695;Reactome: R-HSA-975957;Reactome: R-HSA-72649;Reactome: R-HSA-72764;Reactome: R-HSA-156902	"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Selenocysteine synthesis";"Major pathway of rRNA processing in the nucleolus and cytosol";"Ribosomal scanning and start codon recognition";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Viral mRNA Translation";"Formation of a pool of free 40S subunits";"SRP-dependent cotranslational protein targeting to membrane";"Formation of the ternary complex, and subsequently, the 43S complex";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Translation initiation complex formation";"Eukaryotic Translation Termination";"Peptide chain elongation"
XP_046436258.1	1	KEGG: 00480+3.4.11.1	"Glutathione metabolism"
XP_046432404.1	17	Reactome: R-HSA-5693579;Reactome: R-HSA-2559586;Reactome: R-HSA-5693607;Reactome: R-HSA-912446;Reactome: R-HSA-5693548;Reactome: R-HSA-5685942;Reactome: R-HSA-5693568;Reactome: R-HSA-5685938;Reactome: R-HSA-5685939;Reactome: R-HSA-5693554;Reactome: R-HSA-5693565;Reactome: R-HSA-5693616;Reactome: R-HSA-3270619;Reactome: R-HSA-69473;Reactome: R-HSA-5693571;Reactome: R-HSA-6804756;Reactome: R-HSA-1834949	"Homologous DNA Pairing and Strand Exchange";"DNA Damage/Telomere Stress Induced Senescence";"Processing of DNA double-strand break ends";"Meiotic recombination";"Sensing of DNA Double Strand Breaks";"HDR through Homologous Recombination (HRR)";"Resolution of D-loop Structures through Holliday Junction Intermediates";"HDR through Single Strand Annealing (SSA)";"HDR through MMEJ (alt-NHEJ)";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Presynaptic phase of homologous DNA pairing and strand exchange";"IRF3-mediated induction of type I IFN";"G2/M DNA damage checkpoint";"Nonhomologous End-Joining (NHEJ)";"Regulation of TP53 Activity through Phosphorylation";"Cytosolic sensors of pathogen-associated DNA"
XP_046411403.1	5	MetaCyc: PWY-7269;KEGG: 00760+2.7.1.23;MetaCyc: PWY-5083;Reactome: R-HSA-196807;MetaCyc: PWY-7268	"NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)";"Nicotinate and nicotinamide metabolism";"NAD/NADH phosphorylation and dephosphorylation";"Nicotinate metabolism";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)"
XP_046423914.1	1	Reactome: R-HSA-162658	"Golgi Cisternae Pericentriolar Stack Reorganization"
XP_046434144.1	13	Reactome: R-HSA-2024101;KEGG: 00520+3.2.1.52;KEGG: 00531+3.2.1.52;Reactome: R-HSA-2160916;KEGG: 00513+3.2.1.52;MetaCyc: PWY-7822;MetaCyc: PWY-6902;KEGG: 00603+3.2.1.52;KEGG: 00511+3.2.1.52;KEGG: 00604+3.2.1.52;Reactome: R-HSA-2022857;MetaCyc: PWY-7883;Reactome: R-HSA-1660662	"CS/DS degradation";"Amino sugar and nucleotide sugar metabolism";"Glycosaminoglycan degradation";"Hyaluronan uptake and degradation";"Various types of N-glycan biosynthesis";"Chitin degradation III (Serratia)";"Chitin degradation II (Vibrio)";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Other glycan degradation";"Glycosphingolipid biosynthesis - ganglio series";"Keratan sulfate degradation";"Anhydromuropeptides recycling II";"Glycosphingolipid metabolism"
XP_046423908.1	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
XP_046427497.1	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
XP_046431124.1	2	Reactome: R-HSA-390522;Reactome: R-HSA-445355	"Striated Muscle Contraction";"Smooth Muscle Contraction"
XP_046436250.1	2	Reactome: R-HSA-2022928;MetaCyc: PWY-6558	"HS-GAG biosynthesis";"Heparan sulfate biosynthesis (late stages)"
XP_046426179.1	2	Reactome: R-HSA-9033241;Reactome: R-HSA-389661	"Peroxisomal protein import";"Glyoxylate metabolism and glycine degradation"
XP_046413057.1	1	Reactome: R-HSA-6811440	"Retrograde transport at the Trans-Golgi-Network"
XP_046421023.1	6	MetaCyc: PWY-7782;MetaCyc: PWY-5884;MetaCyc: PWY-6733;Reactome: R-HSA-9640463;MetaCyc: PWY-7656;KEGG: 00073+1.2.1.84	"Plasmalogen biosynthesis";"Wax esters biosynthesis I";"Sporopollenin precursors biosynthesis";"Wax biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Cutin, suberine and wax biosynthesis"
XP_046422098.1	1	Reactome: R-HSA-6804754	"Regulation of TP53 Expression"
XP_046427245.1	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
XP_046419252.1	1	Reactome: R-HSA-352230	"Amino acid transport across the plasma membrane"
XP_046417994.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_046413569.1	9	Reactome: R-HSA-76042;Reactome: R-HSA-75953;Reactome: R-HSA-167172;Reactome: R-HSA-167162;Reactome: R-HSA-6807505;Reactome: R-HSA-167161;Reactome: R-HSA-674695;Reactome: R-HSA-73776;Reactome: R-HSA-73779	"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II Transcription Initiation";"Transcription of the HIV genome";"RNA Polymerase II HIV Promoter Escape";"RNA polymerase II transcribes snRNA genes";"HIV Transcription Initiation";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"
XP_046414799.1	1	Reactome: R-HSA-2173788	"Downregulation of TGF-beta receptor signaling"
XP_046410567.1	2	Reactome: R-HSA-375276;Reactome: R-HSA-418594	"Peptide ligand-binding receptors";"G alpha (i) signalling events"
XP_046421872.1	7	KEGG: 04926+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1	"Relaxin signaling pathway";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Human cytomegalovirus infection";"Thermogenesis";"PI3K-Akt signaling pathway";"mTOR signaling pathway"
XP_046428772.1	7	KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1	"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Relaxin signaling pathway";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Human cytomegalovirus infection";"Thermogenesis"
XP_046419805.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046433560.1	3	MetaCyc: PWY-7511;Reactome: R-HSA-1358803;Reactome: R-HSA-983168	"Protein ubiquitination";"Downregulation of ERBB2:ERBB3 signaling";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046425004.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_046419839.1	3	KEGG: 00730+3.1.3.2;KEGG: 00740+3.1.3.2;MetaCyc: PWY-6348	"Thiamine metabolism";"Riboflavin metabolism";"Phosphate acquisition"
XP_046431658.1	6	Reactome: R-HSA-446210;KEGG: 00520+3.5.1.25;KEGG: 00052+3.5.1.25;MetaCyc: PWY-6906;MetaCyc: PWY-7395;MetaCyc: PWY-7077	"Synthesis of UDP-N-acetyl-glucosamine";"Amino sugar and nucleotide sugar metabolism";"Galactose metabolism";"Chitin derivatives degradation";"D-galactosamine and N-acetyl-D-galactosamine degradation";"N-acetyl-D-galactosamine degradation"
XP_046418528.1	1	Reactome: R-HSA-975957	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
XP_046413064.1	7	Reactome: R-HSA-3371453;Reactome: R-HSA-381033;Reactome: R-HSA-381070;Reactome: R-HSA-114608;Reactome: R-HSA-381042;Reactome: R-HSA-983170;Reactome: R-HSA-381183	"Regulation of HSF1-mediated heat shock response";"ATF6 (ATF6-alpha) activates chaperones";"IRE1alpha activates chaperones";"Platelet degranulation";"PERK regulates gene expression";"Antigen Presentation: Folding, assembly and peptide loading of class I MHC";"ATF6 (ATF6-alpha) activates chaperone genes"
XP_046433655.1	8	Reactome: R-HSA-2426168;KEGG: 00900+1.1.1.34;MetaCyc: PWY-7524;Reactome: R-HSA-191273;MetaCyc: PWY-922;MetaCyc: PWY-7391;MetaCyc: PWY-6174;Reactome: R-HSA-1989781	"Activation of gene expression by SREBF (SREBP)";"Terpenoid backbone biosynthesis";"Mevalonate pathway III (archaea)";"Cholesterol biosynthesis";"Mevalonate pathway I";"Isoprene biosynthesis II (engineered)";"Mevalonate pathway II (archaea)";"PPARA activates gene expression"
XP_046430875.1	1	Reactome: R-HSA-5576886	"Phase 4 - resting membrane potential"
XP_046424104.1	4	Reactome: R-HSA-6798695;Reactome: R-HSA-6802952;Reactome: R-HSA-1632852;Reactome: R-HSA-983168	"Neutrophil degranulation";"Signaling by BRAF and RAF fusions";"Macroautophagy";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046412194.1	1	Reactome: R-HSA-8949613	"Cristae formation"
XP_046423629.1	3	Reactome: R-HSA-2206282;Reactome: R-HSA-2024096;KEGG: 00531+3.2.1.50	"MPS IIIB - Sanfilippo syndrome B";"HS-GAG degradation";"Glycosaminoglycan degradation"
XP_046429492.1	5	KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16;Reactome: R-HSA-5687128;KEGG: 05235+3.1.3.16;Reactome: R-HSA-176407	"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation";"MAPK6/MAPK4 signaling";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase"
XP_046430153.1	5	Reactome: R-HSA-70171;MetaCyc: PWY-5514;MetaCyc: PWY-6906;KEGG: 00520+3.5.99.6;MetaCyc: PWY-6855	"Glycolysis";"UDP-N-acetyl-D-galactosamine biosynthesis II";"Chitin derivatives degradation";"Amino sugar and nucleotide sugar metabolism";"Chitin degradation I (archaea)"
XP_046424127.1	18	Reactome: R-HSA-5362517;Reactome: R-HSA-71064;KEGG: 00020+1.8.1.4;KEGG: 00280+1.8.1.4;Reactome: R-HSA-6783984;KEGG: 00380+1.8.1.4;Reactome: R-HSA-70895;MetaCyc: PWY-5084;KEGG: 00640+1.8.1.4;Reactome: R-HSA-389661;Reactome: R-HSA-71403;KEGG: 00010+1.8.1.4;Reactome: R-HSA-204174;KEGG: 00260+1.8.1.4;MetaCyc: PWY-5046;KEGG: 00620+1.8.1.4;Reactome: R-HSA-70268;KEGG: 00310+1.8.1.4	"Signaling by Retinoic Acid";"Lysine catabolism";"Citrate cycle (TCA cycle)";"Valine, leucine and isoleucine degradation";"Glycine degradation";"Tryptophan metabolism";"Branched-chain amino acid catabolism";"2-oxoglutarate decarboxylation to succinyl-CoA";"Propanoate metabolism";"Glyoxylate metabolism and glycine degradation";"Citric acid cycle (TCA cycle)";"Glycolysis / Gluconeogenesis";"Regulation of pyruvate dehydrogenase (PDH) complex";"Glycine, serine and threonine metabolism";"2-oxoisovalerate decarboxylation to isobutanoyl-CoA";"Pyruvate metabolism";"Pyruvate metabolism";"Lysine degradation"
XP_046424065.1	11	Reactome: R-HSA-975634;Reactome: R-HSA-202733;Reactome: R-HSA-2024096;Reactome: R-HSA-2022928;Reactome: R-HSA-3656237;Reactome: R-HSA-1971475;Reactome: R-HSA-3656253;Reactome: R-HSA-3000170;Reactome: R-HSA-4420332;Reactome: R-HSA-3560801;Reactome: R-HSA-3560783	"Retinoid metabolism and transport";"Cell surface interactions at the vascular wall";"HS-GAG degradation";"HS-GAG biosynthesis";"Defective EXT2 causes exostoses 2";"A tetrasaccharide linker sequence is required for GAG synthesis";"Defective EXT1 causes exostoses 1, TRPS2 and CHDS";"Syndecan interactions";"Defective B3GALT6 causes EDSP2 and SEMDJL1";"Defective B3GAT3 causes JDSSDHD";"Defective B4GALT7 causes EDS, progeroid type"
XP_046426633.1	4	Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-1268020;Reactome: R-HSA-5419276	"Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial protein import";"Mitochondrial translation termination"
XP_046427983.1	2	Reactome: R-HSA-1989781;Reactome: R-HSA-2151201	"PPARA activates gene expression";"Transcriptional activation of mitochondrial biogenesis"
XP_046426442.1	3	Reactome: R-HSA-6782135;Reactome: R-HSA-5696400;Reactome: R-HSA-5696395	"Dual incision in TC-NER";"Dual Incision in GG-NER";"Formation of Incision Complex in GG-NER"
XP_046433240.1	1	Reactome: R-HSA-3295583	"TRP channels"
XP_046424516.1	1	Reactome: R-HSA-156842	"Eukaryotic Translation Elongation"
XP_046413533.1	1	Reactome: R-HSA-1632852	"Macroautophagy"
XP_046431716.1	1	Reactome: R-HSA-6809371	"Formation of the cornified envelope"
XP_046434697.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_046422593.1	1	Reactome: R-HSA-191859	"snRNP Assembly"
XP_046425293.1	1	Reactome: R-HSA-73621	"Pyrimidine catabolism"
XP_046431967.1	6	Reactome: R-HSA-5620922;Reactome: R-HSA-389957;Reactome: R-HSA-389960;Reactome: R-HSA-390471;Reactome: R-HSA-390450;Reactome: R-HSA-6814122	"BBSome-mediated cargo-targeting to cilium";"Prefoldin mediated transfer of substrate to CCT/TriC";"Formation of tubulin folding intermediates by CCT/TriC";"Association of TriC/CCT with target proteins during biosynthesis";"Folding of actin by CCT/TriC";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"
XP_046434450.1	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
XP_046421244.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046420364.1	3	MetaCyc: PWY-5963;KEGG: 00790+2.8.1.9;Reactome: R-HSA-947581	"Thio-molybdenum cofactor biosynthesis";"Folate biosynthesis";"Molybdenum cofactor biosynthesis"
XP_046420954.1	3	Reactome: R-HSA-2142691;MetaCyc: PWY-7533;Reactome: R-HSA-5423646	"Synthesis of Leukotrienes (LT) and Eoxins (EX)";"Gliotoxin biosynthesis";"Aflatoxin activation and detoxification"
XP_046409504.1	1	Reactome: R-HSA-5689603	"UCH proteinases"
XP_046416081.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-5628897	"Respiratory electron transport";"TP53 Regulates Metabolic Genes"
XP_046420311.1	7	MetaCyc: PWY-5469;MetaCyc: PWY-5466;MetaCyc: PWY-7445;MetaCyc: PWY-6824;MetaCyc: PWY-7214;KEGG: 00940+1.11.1.7;MetaCyc: PWY-5461	"Sesamin biosynthesis";"Matairesinol biosynthesis";"Luteolin triglucuronide degradation";"Justicidin B biosynthesis";"Baicalein degradation (hydrogen peroxide detoxification)";"Phenylpropanoid biosynthesis";"Betanidin degradation"
XP_046419923.1	8	Reactome: R-HSA-5083633;MetaCyc: PWY-7979;KEGG: 00515+2.4.1.109;KEGG: 00514+2.4.1.109;MetaCyc: PWY-7921;Reactome: R-HSA-5173105;Reactome: R-HSA-5083629;MetaCyc: PWY-7922	"Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1";"Protein O-mannosylation III (mammals, core M3)";"Mannose type O-glycan biosynthesis";"Other types of O-glycan biosynthesis";"Protein O-mannosylation I (yeast)";"O-linked glycosylation";"Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2";"Protein O-mannosylation II (mammals, core M1 and core M2)"
XP_046429369.1	7	KEGG: 04926+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1	"Relaxin signaling pathway";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Human cytomegalovirus infection";"Thermogenesis";"PI3K-Akt signaling pathway";"mTOR signaling pathway"
XP_046427461.1	5	KEGG: 00520+3.2.1.14;Reactome: R-HSA-189085;MetaCyc: PWY-6902;MetaCyc: PWY-6855;MetaCyc: PWY-7822	"Amino sugar and nucleotide sugar metabolism";"Digestion of dietary carbohydrate";"Chitin degradation II (Vibrio)";"Chitin degradation I (archaea)";"Chitin degradation III (Serratia)"
XP_046415654.1	8	Reactome: R-HSA-4641263;Reactome: R-HSA-4608870;Reactome: R-HSA-5099900;Reactome: R-HSA-8856825;Reactome: R-HSA-5340588;Reactome: R-HSA-373080;Reactome: R-HSA-8856828;Reactome: R-HSA-4086398	"Regulation of FZD by ubiquitination";"Asymmetric localization of PCP proteins";"WNT5A-dependent internalization of FZD4";"Cargo recognition for clathrin-mediated endocytosis";"RNF mutants show enhanced WNT signaling and proliferation";"Class B/2 (Secretin family receptors)";"Clathrin-mediated endocytosis";"Ca2+ pathway"
XP_046435894.1	3	Reactome: R-HSA-8963901;Reactome: R-HSA-6807878;Reactome: R-HSA-445095	"Chylomicron remodeling";"COPI-mediated anterograde transport";"Interaction between L1 and Ankyrins"
XP_046417356.1	2	Reactome: R-HSA-8876198;Reactome: R-HSA-204005	"RAB GEFs exchange GTP for GDP on RABs";"COPII-mediated vesicle transport"
XP_046433952.1	2	Reactome: R-HSA-388479;Reactome: R-HSA-416476	"Vasopressin-like receptors";"G alpha (q) signalling events"
XP_046417126.1	2	Reactome: R-HSA-390471;Reactome: R-HSA-1660662	"Association of TriC/CCT with target proteins during biosynthesis";"Glycosphingolipid metabolism"
XP_046431428.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046423686.1	11	Reactome: R-HSA-6782210;Reactome: R-HSA-68952;Reactome: R-HSA-5696397;Reactome: R-HSA-110314;Reactome: R-HSA-5685942;Reactome: R-HSA-5651801;Reactome: R-HSA-68962;Reactome: R-HSA-5696400;Reactome: R-HSA-5656169;Reactome: R-HSA-6782135;Reactome: R-HSA-174430	"Gap-filling DNA repair synthesis and ligation in TC-NER";"DNA replication initiation";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Recognition of DNA damage by PCNA-containing replication complex";"HDR through Homologous Recombination (HRR)";"PCNA-Dependent Long Patch Base Excision Repair";"Activation of the pre-replicative complex";"Dual Incision in GG-NER";"Termination of translesion DNA synthesis";"Dual incision in TC-NER";"Telomere C-strand synthesis initiation"
XP_046411469.1	8	Reactome: R-HSA-141444;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813;Reactome: R-HSA-4615885;Reactome: R-HSA-68877;Reactome: R-HSA-165054;Reactome: R-HSA-2500257;Reactome: R-HSA-5663220	"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids";"SUMOylation of DNA replication proteins";"Mitotic Prometaphase";"Rev-mediated nuclear export of HIV RNA";"Resolution of Sister Chromatid Cohesion";"RHO GTPases Activate Formins"
XP_046427376.1	5	Reactome: R-HSA-68949;Reactome: R-HSA-68962;Reactome: R-HSA-69205;Reactome: R-HSA-68867;Reactome: R-HSA-68827	"Orc1 removal from chromatin";"Activation of the pre-replicative complex";"G1/S-Specific Transcription";"Assembly of the pre-replicative complex";"CDT1 association with the CDC6:ORC:origin complex"
XP_046430244.1	5	KEGG: 00630+4.2.1.3;KEGG: 00720+4.2.1.3;Reactome: R-HSA-917937;KEGG: 00290+4.2.1.33;KEGG: 00020+4.2.1.3	"Glyoxylate and dicarboxylate metabolism";"Carbon fixation pathways in prokaryotes";"Iron uptake and transport";"Valine, leucine and isoleucine biosynthesis";"Citrate cycle (TCA cycle)"
XP_046427354.1	2	Reactome: R-HSA-1989781;Reactome: R-HSA-381340	"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation"
XP_046430299.1	6	Reactome: R-HSA-68962;Reactome: R-HSA-68949;Reactome: R-HSA-69052;Reactome: R-HSA-68867;Reactome: R-HSA-176974;Reactome: R-HSA-176187	"Activation of the pre-replicative complex";"Orc1 removal from chromatin";"Switching of origins to a post-replicative state";"Assembly of the pre-replicative complex";"Unwinding of DNA";"Activation of ATR in response to replication stress"
XP_046417977.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_046413553.1	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
XP_046410701.1	3	MetaCyc: PWY-8106;Reactome: R-HSA-6782315;MetaCyc: PWY-6700	"Queuosine biosynthesis III (queuosine salvage)";"tRNA modification in the nucleus and cytosol";"Queuosine biosynthesis I (de novo)"
XP_046418151.1	1	Reactome: R-HSA-1445148	"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
XP_046427264.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046416928.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046430046.1	26	Reactome: R-HSA-9013508;Reactome: R-HSA-2644606;Reactome: R-HSA-3899300;Reactome: R-HSA-2122947;Reactome: R-HSA-8941856;Reactome: R-HSA-9013695;Reactome: R-HSA-201722;Reactome: R-HSA-3214847;Reactome: R-HSA-5621575;Reactome: R-HSA-210744;Reactome: R-HSA-3371568;Reactome: R-HSA-918233;Reactome: R-HSA-9614657;Reactome: R-HSA-1234158;Reactome: R-HSA-5617472;Reactome: R-HSA-381340;Reactome: R-HSA-9617629;Reactome: R-HSA-3134973;Reactome: R-HSA-8866907;Reactome: R-HSA-933541;Reactome: R-HSA-2894862;Reactome: R-HSA-1368082;Reactome: R-HSA-400253;Reactome: R-HSA-9018519;Reactome: R-HSA-1989781;Reactome: R-HSA-1912408	"NOTCH3 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"SUMOylation of transcription cofactors";"NOTCH1 Intracellular Domain Regulates Transcription";"RUNX3 regulates NOTCH signaling";"NOTCH4 Intracellular Domain Regulates Transcription";"Formation of the beta-catenin:TCF transactivating complex";"HATs acetylate histones";"CD209 (DC-SIGN) signaling";"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"Attenuation phase";"TRAF3-dependent IRF activation pathway";"FOXO-mediated transcription of cell death genes";"Regulation of gene expression by Hypoxia-inducible Factor";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Transcriptional regulation of white adipocyte differentiation";"Regulation of FOXO transcriptional activity by acetylation";"LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production";"Activation of the TFAP2 (AP-2) family of transcription factors";"TRAF6 mediated IRF7 activation";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"RORA activates gene expression";"Circadian Clock";"Estrogen-dependent gene expression";"PPARA activates gene expression";"Pre-NOTCH Transcription and Translation"
XP_046425795.1	60	MetaCyc: PWY-6435;KEGG: 00310+4.2.1.17;MetaCyc: PWY-6583;MetaCyc: PWY-7401;KEGG: 00071+5.1.2.3+4.2.1.17+1.1.1.35;KEGG: 00640+4.2.1.17;MetaCyc: PWY-7656;KEGG: 00281+4.2.1.17+1.1.1.35;KEGG: 00280+4.2.1.17+1.1.1.35;MetaCyc: PWY-7779;Reactome: R-HSA-1482798;MetaCyc: PWY-7007;KEGG: 00362+4.2.1.17+1.1.1.35;Reactome: R-HSA-77346;Reactome: R-HSA-77350;KEGG: 00650+4.2.1.17;MetaCyc: PWY-6945;MetaCyc: PWY-6883;MetaCyc: PWY-7606;MetaCyc: PWY-6946;KEGG: 00930+4.2.1.17;MetaCyc: PWY-7726;MetaCyc: PWY-6863;Reactome: R-HSA-77305;KEGG: 00062+4.2.1.17+1.1.1.35;KEGG: 00650+4.2.1.17+1.1.1.35;KEGG: 00903+4.2.1.17;MetaCyc: PWY-5136;KEGG: 00281+4.2.1.17;KEGG: 00650+5.1.2.3+4.2.1.17+1.1.1.35;Reactome: R-HSA-77285;KEGG: 00380+4.2.1.17+1.1.1.35;KEGG: 00362+4.2.1.17;MetaCyc: PWY-1361;KEGG: 00592+4.2.1.17;KEGG: 00071+4.2.1.17+1.1.1.35;KEGG: 00720+4.2.1.17;Reactome: R-HSA-77348;Reactome: R-HSA-77288;MetaCyc: PWY-7094;MetaCyc: PWY-5109;MetaCyc: PWY-6944;KEGG: 00360+4.2.1.17;KEGG: 00062+4.2.1.17+1.1.1.211;MetaCyc: PWY-5789;KEGG: 00930+4.2.1.17+1.1.1.35;KEGG: 00071+4.2.1.17+1.1.1.211;KEGG: 00627+4.2.1.17;MetaCyc: PWY-7216;MetaCyc: PWY-5177;KEGG: 00380+4.2.1.17;MetaCyc: PWY-7654;MetaCyc: PWY-7778;KEGG: 00310+4.2.1.17+1.1.1.35;KEGG: 00280+4.2.1.17;MetaCyc: PWY-5138;Reactome: R-HSA-77310;KEGG: 00623+1.1.1.35;KEGG: 00410+4.2.1.17;KEGG: 00720+4.2.1.17+1.1.1.35	"4-hydroxybenzoate biosynthesis III (plants)";"Lysine degradation";"Pyruvate fermentation to butanol I";"Crotonate fermentation (to acetate and cyclohexane carboxylate)";"Fatty acid degradation";"Propanoate metabolism";"Spodoptera littoralis pheromone biosynthesis";"Geraniol degradation";"Valine, leucine and isoleucine degradation";"Methyl tert-butyl ether degradation";"Acyl chain remodeling of CL";"Methyl ketone biosynthesis (engineered)";"Benzoate degradation";"Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA";"Beta oxidation of hexanoyl-CoA to butanoyl-CoA";"Butanoate metabolism";"Cholesterol degradation to androstenedione I (cholesterol oxidase)";"Pyruvate fermentation to butanol II (engineered)";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Cholesterol degradation to androstenedione II (cholesterol dehydrogenase)";"Caprolactam degradation";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"Pyruvate fermentation to hexanol (engineered)";"Beta oxidation of palmitoyl-CoA to myristoyl-CoA";"Fatty acid elongation";"Butanoate metabolism";"Limonene and pinene degradation";"Fatty acid beta-oxidation II (plant peroxisome)";"Geraniol degradation";"Butanoate metabolism";"Beta oxidation of myristoyl-CoA to lauroyl-CoA";"Tryptophan metabolism";"Benzoate degradation";"Benzoyl-coa degradation I (aerobic)";"alpha-Linolenic acid metabolism";"Fatty acid degradation";"Carbon fixation pathways in prokaryotes";"Beta oxidation of octanoyl-CoA to hexanoyl-CoA";"mitochondrial fatty acid beta-oxidation of unsaturated fatty acids";"Fatty acid salvage";"Fermentation to 2-methylbutanoate";"Androstenedione degradation";"Phenylalanine metabolism";"Fatty acid elongation";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Caprolactam degradation";"Fatty acid degradation";"Aminobenzoate degradation";"(R)- and (S)-3-hydroxybutanoate biosynthesis (engineered)";"Glutaryl-coa degradation";"Tryptophan metabolism";"(8E,10E)-dodeca-8,10-dienol biosynthesis";"2-methylpropene degradation";"Lysine degradation";"Valine, leucine and isoleucine degradation";"Fatty acid beta-oxidation IV (unsaturated, even number)";"Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA";"Toluene degradation";"beta-Alanine metabolism";"Carbon fixation pathways in prokaryotes"
XP_046434086.1	1	Reactome: R-HSA-1296061	"HCN channels"
XP_046412891.1	14	MetaCyc: PWY-3781;MetaCyc: PWY-5690;Reactome: R-HSA-71403;MetaCyc: PWY-7279;KEGG: 00720+1.3.5.1;KEGG: 00190+1.3.5.1;KEGG: 00020+1.3.5.1;KEGG: 00650+1.3.5.1;Reactome: R-HSA-611105;MetaCyc: PWY-6969;MetaCyc: PWY-6728;MetaCyc: PWY-7254;MetaCyc: PWY-4302;MetaCyc: PWY-561	"Aerobic respiration I (cytochrome c)";"TCA cycle II (plants and fungi)";"Citric acid cycle (TCA cycle)";"Aerobic respiration II (cytochrome c) (yeast)";"Carbon fixation pathways in prokaryotes";"Oxidative phosphorylation";"Citrate cycle (TCA cycle)";"Butanoate metabolism";"Respiratory electron transport";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Methylaspartate cycle";"TCA cycle VII (acetate-producers)";"Aerobic respiration III (alternative oxidase pathway)";"Superpathway of glyoxylate cycle and fatty acid degradation"
XP_046416084.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_046434622.1	1	Reactome: R-HSA-5620912	"Anchoring of the basal body to the plasma membrane"
XP_046426094.1	1	MetaCyc: PWY-6829	"Trna methylation (yeast)"
XP_046410295.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_046414298.1	6	Reactome: R-HSA-9648025;Reactome: R-HSA-141444;Reactome: R-HSA-68877;Reactome: R-HSA-2467813;Reactome: R-HSA-5663220;Reactome: R-HSA-2500257	"EML4 and NUDC in mitotic spindle formation";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Mitotic Prometaphase";"Separation of Sister Chromatids";"RHO GTPases Activate Formins";"Resolution of Sister Chromatid Cohesion"
XP_046424487.1	4	MetaCyc: PWY-6281;Reactome: R-HSA-379716;KEGG: 00970+6.1.1.11;Reactome: R-HSA-2408557	"L-selenocysteine biosynthesis II (archaea and eukaryotes)";"Cytosolic tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis";"Selenocysteine synthesis"
XP_046412109.1	17	Reactome: R-HSA-139915;Reactome: R-HSA-2559585;Reactome: R-HSA-6804114;Reactome: R-HSA-1912408;Reactome: R-HSA-111448;Reactome: R-HSA-2173796;Reactome: R-HSA-1538133;Reactome: R-HSA-69231;Reactome: R-HSA-8953750;Reactome: R-HSA-9616222;Reactome: R-HSA-1362300;Reactome: R-HSA-113501;Reactome: R-HSA-69202;Reactome: R-HSA-69656;Reactome: R-HSA-2559580;Reactome: R-HSA-1362277;Reactome: R-HSA-69205	"Activation of PUMA and translocation to mitochondria";"Oncogene Induced Senescence";"TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest";"Pre-NOTCH Transcription and Translation";"Activation of NOXA and translocation to mitochondria";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"G0 and Early G1";"Cyclin D associated events in G1";"Transcriptional Regulation by E2F6";"Transcriptional regulation of granulopoiesis";"Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1";"Inhibition of replication initiation of damaged DNA by RB1/E2F1";"Cyclin E associated events during G1/S transition";"Cyclin A:Cdk2-associated events at S phase entry";"Oxidative Stress Induced Senescence";"Transcription of E2F targets under negative control by DREAM complex";"G1/S-Specific Transcription"
XP_046429934.1	5	MetaCyc: PWY-7921;KEGG: 00514+2.4.1.109;MetaCyc: PWY-7979;KEGG: 00515+2.4.1.109;MetaCyc: PWY-7922	"Protein O-mannosylation I (yeast)";"Other types of O-glycan biosynthesis";"Protein O-mannosylation III (mammals, core M3)";"Mannose type O-glycan biosynthesis";"Protein O-mannosylation II (mammals, core M1 and core M2)"
XP_046415316.1	14	Reactome: R-HSA-2132295;Reactome: R-HSA-9648025;Reactome: R-HSA-141444;Reactome: R-HSA-9609690;Reactome: R-HSA-68877;Reactome: R-HSA-9646399;Reactome: R-HSA-6811436;Reactome: R-HSA-2467813;Reactome: R-HSA-5620924;Reactome: R-HSA-5663220;Reactome: R-HSA-2500257;Reactome: R-HSA-3371497;Reactome: R-HSA-6807878;Reactome: R-HSA-1632852	"MHC class II antigen presentation";"EML4 and NUDC in mitotic spindle formation";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"HCMV Early Events";"Mitotic Prometaphase";"Aggrephagy";"COPI-independent Golgi-to-ER retrograde traffic";"Separation of Sister Chromatids";"Intraflagellar transport";"RHO GTPases Activate Formins";"Resolution of Sister Chromatid Cohesion";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-mediated anterograde transport";"Macroautophagy"
XP_046425362.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_046414161.1	1	Reactome: R-HSA-163560	"Triglyceride catabolism"
XP_046417749.1	1	Reactome: R-HSA-5693607	"Processing of DNA double-strand break ends"
XP_046428813.1	29	Reactome: R-HSA-167158;Reactome: R-HSA-5696400;Reactome: R-HSA-6781827;Reactome: R-HSA-6782135;Reactome: R-HSA-73779;Reactome: R-HSA-167160;Reactome: R-HSA-73762;Reactome: R-HSA-75953;Reactome: R-HSA-427413;Reactome: R-HSA-167162;Reactome: R-HSA-6781823;Reactome: R-HSA-167246;Reactome: R-HSA-6782210;Reactome: R-HSA-113418;Reactome: R-HSA-73776;Reactome: R-HSA-72086;Reactome: R-HSA-674695;Reactome: R-HSA-77075;Reactome: R-HSA-6796648;Reactome: R-HSA-167200;Reactome: R-HSA-73772;Reactome: R-HSA-167161;Reactome: R-HSA-167152;Reactome: R-HSA-5696395;Reactome: R-HSA-76042;Reactome: R-HSA-75955;Reactome: R-HSA-167172;Reactome: R-HSA-73863;Reactome: R-HSA-112382	"Formation of the HIV-1 Early Elongation Complex";"Dual Incision in GG-NER";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Dual incision in TC-NER";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"RNA Polymerase I Transcription Initiation";"RNA Polymerase II Transcription Initiation";"NoRC negatively regulates rRNA expression";"RNA Polymerase II HIV Promoter Escape";"Formation of TC-NER Pre-Incision Complex";"Tat-mediated elongation of the HIV-1 transcript";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Formation of the Early Elongation Complex";"RNA Polymerase II Promoter Escape";"mRNA Capping";"RNA Polymerase II Pre-transcription Events";"RNA Pol II CTD phosphorylation and interaction with CE";"TP53 Regulates Transcription of DNA Repair Genes";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Polymerase I Promoter Escape";"HIV Transcription Initiation";"Formation of HIV elongation complex in the absence of HIV Tat";"Formation of Incision Complex in GG-NER";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II Transcription Elongation";"Transcription of the HIV genome";"RNA Polymerase I Transcription Termination";"Formation of RNA Pol II elongation complex"
XP_046411785.1	6	MetaCyc: PWY-7356;KEGG: 00730+2.7.6.2;MetaCyc: PWY-6908;Reactome: R-HSA-196819;MetaCyc: PWY-6898;MetaCyc: PWY-6907	"Thiamine salvage IV (yeast)";"Thiamine metabolism";"Thiamine diphosphate biosynthesis IV (eukaryotes)";"Vitamin B1 (thiamin) metabolism";"Thiamine salvage III";"Thiamine diphosphate biosynthesis III (Staphylococcus)"
XP_046436620.1	1	Reactome: R-HSA-2428928	"IRS-related events triggered by IGF1R"
XP_046413985.1	8	KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;Reactome: R-HSA-2028269;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04714+2.7.11.1	"Relaxin signaling pathway";"Human cytomegalovirus infection";"Signaling by Hippo";"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Thermogenesis"
XP_046429585.1	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046425961.1	2	Reactome: R-HSA-8853659;Reactome: R-HSA-5673001	"RET signaling";"RAF/MAP kinase cascade"
XP_046431293.1	1	Reactome: R-HSA-426117	"Cation-coupled Chloride cotransporters"
XP_046423758.1	10	Reactome: R-HSA-167172;Reactome: R-HSA-6807505;Reactome: R-HSA-167162;Reactome: R-HSA-76042;Reactome: R-HSA-75953;Reactome: R-HSA-73779;Reactome: R-HSA-674695;Reactome: R-HSA-73776;Reactome: R-HSA-167161;Reactome: R-HSA-9018519	"Transcription of the HIV genome";"RNA polymerase II transcribes snRNA genes";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Promoter Escape";"HIV Transcription Initiation";"Estrogen-dependent gene expression"
XP_046432464.1	6	KEGG: 00270+2.6.1.52;Reactome: R-HSA-977347;KEGG: 00680+2.6.1.52;KEGG: 00750+2.6.1.52;KEGG: 00260+2.6.1.52;MetaCyc: PWY-8010	"Cysteine and methionine metabolism";"Serine biosynthesis";"Methane metabolism";"Vitamin B6 metabolism";"Glycine, serine and threonine metabolism";"L-cysteine biosynthesis IX (Trichomonas vaginalis)"
XP_046421522.1	3	Reactome: R-HSA-192456;MetaCyc: PWY-6857;KEGG: 00561+3.1.1.3	"Digestion of dietary lipid";"Retinol biosynthesis";"Glycerolipid metabolism"
XP_046415429.1	6	Reactome: R-HSA-181430;Reactome: R-HSA-264642;Reactome: R-HSA-181429;Reactome: R-HSA-210500;Reactome: R-HSA-212676;Reactome: R-HSA-388844	"Norepinephrine Neurotransmitter Release Cycle";"Acetylcholine Neurotransmitter Release Cycle";"Serotonin Neurotransmitter Release Cycle";"Glutamate Neurotransmitter Release Cycle";"Dopamine Neurotransmitter Release Cycle";"Receptor-type tyrosine-protein phosphatases"
XP_046433823.1	7	KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1	"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Human cytomegalovirus infection";"Thermogenesis";"Relaxin signaling pathway";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection"
XP_046413424.1	11	Reactome: R-HSA-2219530;Reactome: R-HSA-6785631;Reactome: R-HSA-5673001;Reactome: R-HSA-1227986;Reactome: R-HSA-8847993;Reactome: R-HSA-1257604;Reactome: R-HSA-9664565;Reactome: R-HSA-1250196;Reactome: R-HSA-6811558;Reactome: R-HSA-8863795;Reactome: R-HSA-1963642	"Constitutive Signaling by Aberrant PI3K in Cancer";"ERBB2 Regulates Cell Motility";"RAF/MAP kinase cascade";"Signaling by ERBB2";"ERBB2 Activates PTK6 Signaling";"PIP3 activates AKT signaling";"Signaling by ERBB2 KD Mutants";"SHC1 events in ERBB2 signaling";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"Downregulation of ERBB2 signaling";"PI3K events in ERBB2 signaling"
XP_046418907.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046424364.1	2	Reactome: R-HSA-399719;Reactome: R-HSA-190873	"Trafficking of AMPA receptors";"Gap junction degradation"
XP_046431610.1	2	Reactome: R-HSA-5693554;Reactome: R-HSA-2564830	"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Cytosolic iron-sulfur cluster assembly"
XP_046425908.1	3	Reactome: R-HSA-6807878;Reactome: R-HSA-6811440;Reactome: R-HSA-6811438	"COPI-mediated anterograde transport";"Retrograde transport at the Trans-Golgi-Network";"Intra-Golgi traffic"
XP_046421923.1	12	MetaCyc: PWY-7417;KEGG: 00564+3.1.1.4;KEGG: 00591+3.1.1.4;MetaCyc: PWY-8053;MetaCyc: PWY-7416;MetaCyc: PWY-7409;MetaCyc: PWY-7783;KEGG: 00592+3.1.1.4;KEGG: 00590+3.1.1.4;MetaCyc: PWY-6803;KEGG: 00565+3.1.1.4;MetaCyc: PWY-8051	"Phospholipid remodeling (phosphatidate, yeast)";"Glycerophospholipid metabolism";"Linoleic acid metabolism";"Anandamide biosynthesis II";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Plasmalogen degradation";"alpha-Linolenic acid metabolism";"Arachidonic acid metabolism";"Phosphatidylcholine acyl editing";"Ether lipid metabolism";"Anandamide biosynthesis I"
XP_046416975.1	1	Reactome: R-HSA-6794361	"Neurexins and neuroligins"
XP_046428289.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_046422140.1	6	KEGG: 00500+2.4.1.18;KEGG: 00500+3.2.1.1;Reactome: R-HSA-189085;MetaCyc: PWY-622;MetaCyc: PWY-7900;MetaCyc: PWY-5067	"Starch and sucrose metabolism";"Starch and sucrose metabolism";"Digestion of dietary carbohydrate";"Starch biosynthesis";"Glycogen biosynthesis III (from alpha-maltose 1-phosphate)";"Glycogen biosynthesis II (from UDP-D-Glucose)"
XP_046412996.1	27	Reactome: R-HSA-4551638;Reactome: R-HSA-165054;Reactome: R-HSA-4085377;Reactome: R-HSA-6784531;Reactome: R-HSA-3232142;Reactome: R-HSA-170822;Reactome: R-HSA-180910;Reactome: R-HSA-3371453;Reactome: R-HSA-159236;Reactome: R-HSA-9609690;Reactome: R-HSA-3108214;Reactome: R-HSA-168325;Reactome: R-HSA-1169408;Reactome: R-HSA-159231;Reactome: R-HSA-4570464;Reactome: R-HSA-9610379;Reactome: R-HSA-159227;Reactome: R-HSA-168333;Reactome: R-HSA-168271;Reactome: R-HSA-159230;Reactome: R-HSA-180746;Reactome: R-HSA-5578749;Reactome: R-HSA-191859;Reactome: R-HSA-4615885;Reactome: R-HSA-168276;Reactome: R-HSA-3301854;Reactome: R-HSA-5619107	"SUMOylation of chromatin organization proteins";"Rev-mediated nuclear export of HIV RNA";"SUMOylation of SUMOylation proteins";"tRNA processing in the nucleus";"SUMOylation of ubiquitinylation proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Vpr-mediated nuclear import of PICs";"Regulation of HSF1-mediated heat shock response";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"HCMV Early Events";"SUMOylation of DNA damage response and repair proteins";"Viral Messenger RNA Synthesis";"ISG15 antiviral mechanism";"Transport of Mature mRNA Derived from an Intronless Transcript";"SUMOylation of RNA binding proteins";"HCMV Late Events";"Transport of the SLBP independent Mature mRNA";"NEP/NS2 Interacts with the Cellular Export Machinery";"Transport of Ribonucleoproteins into the Host Nucleus";"Transport of the SLBP Dependant Mature mRNA";"Nuclear import of Rev protein";"Transcriptional regulation by small RNAs";"snRNP Assembly";"SUMOylation of DNA replication proteins";"NS1 Mediated Effects on Host Pathways";"Nuclear Pore Complex (NPC) Disassembly";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)"
XP_046420505.1	1	Reactome: R-HSA-428359	"Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA"
XP_046410469.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046419551.1	2	KEGG: 00240+3.6.1.23;KEGG: 00983+3.6.1.23	"Pyrimidine metabolism";"Drug metabolism - other enzymes"
XP_046413927.1	4	Reactome: R-HSA-8856825;Reactome: R-HSA-5696394;Reactome: R-HSA-8951664;Reactome: R-HSA-6781823	"Cargo recognition for clathrin-mediated endocytosis";"DNA Damage Recognition in GG-NER";"Neddylation";"Formation of TC-NER Pre-Incision Complex"
XP_046418881.1	8	Reactome: R-HSA-163615;Reactome: R-HSA-180024;Reactome: R-HSA-5610787;Reactome: R-HSA-442720;Reactome: R-HSA-381676;Reactome: R-HSA-983231;Reactome: R-HSA-432040;Reactome: R-HSA-164378	"PKA activation";"DARPP-32 events";"Hedgehog 'off' state";"CREB1 phosphorylation through the activation of Adenylate Cyclase";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"Factors involved in megakaryocyte development and platelet production";"Vasopressin regulates renal water homeostasis via Aquaporins";"PKA activation in glucagon signalling"
XP_046422048.1	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
XP_046424506.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_046428658.1	1	Reactome: R-HSA-197264	"Nicotinamide salvaging"
XP_046431674.1	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
XP_046422212.1	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
XP_046421386.1	1	Reactome: R-HSA-1237044	"Erythrocytes take up carbon dioxide and release oxygen"
XP_046433613.1	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_046420986.1	1	Reactome: R-HSA-4551638	"SUMOylation of chromatin organization proteins"
XP_046416222.1	1	Reactome: R-HSA-2514853	"Condensation of Prometaphase Chromosomes"
XP_046425587.1	1	Reactome: R-HSA-2132295	"MHC class II antigen presentation"
XP_046415989.1	1	Reactome: R-HSA-70895	"Branched-chain amino acid catabolism"
XP_046410970.1	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
XP_046416645.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046418916.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046434768.1	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
XP_046432717.1	6	MetaCyc: PWY-7920;KEGG: 00513+2.4.1.143;Reactome: R-HSA-4793952;KEGG: 00510+2.4.1.143;MetaCyc: PWY-7426;Reactome: R-HSA-975578	"Complex N-linked glycan biosynthesis (plants)";"Various types of N-glycan biosynthesis";"Defective MGAT2 causes MGAT2-CDG (CDG-2a)";"N-Glycan biosynthesis";"Complex N-linked glycan biosynthesis (vertebrates)";"Reactions specific to the complex N-glycan synthesis pathway"
XP_046430735.1	3	Reactome: R-HSA-1445148;Reactome: R-HSA-5620916;Reactome: R-HSA-264876	"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"VxPx cargo-targeting to cilium";"Insulin processing"
XP_046430204.1	2	Reactome: R-HSA-3928665;Reactome: R-HSA-2682334	"EPH-ephrin mediated repulsion of cells";"EPH-Ephrin signaling"
XP_046433252.1	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046429564.1	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
XP_046423342.1	2	KEGG: 00230+3.1.4.53;Reactome: R-HSA-180024	"Purine metabolism";"DARPP-32 events"
XP_046428594.1	2	Reactome: R-HSA-164843;Reactome: R-HSA-5693571	"2-LTR circle formation";"Nonhomologous End-Joining (NHEJ)"
XP_046434510.1	2	Reactome: R-HSA-6783310;Reactome: R-HSA-5693568	"Fanconi Anemia Pathway";"Resolution of D-loop Structures through Holliday Junction Intermediates"
XP_046425970.1	19	Reactome: R-HSA-8856825;Reactome: R-HSA-432142;Reactome: R-HSA-8856828;Reactome: R-HSA-8964038;Reactome: R-HSA-8957275;Reactome: R-HSA-8964026;Reactome: R-HSA-8963901;Reactome: R-HSA-8866423;Reactome: R-HSA-8963888;Reactome: R-HSA-3000480;Reactome: R-HSA-3000497;Reactome: R-HSA-3000484;Reactome: R-HSA-381426;Reactome: R-HSA-8964041;Reactome: R-HSA-975634;Reactome: R-HSA-8964046;Reactome: R-HSA-5686938;Reactome: R-HSA-3000471;Reactome: R-HSA-202733	"Cargo recognition for clathrin-mediated endocytosis";"Platelet sensitization by LDL";"Clathrin-mediated endocytosis";"LDL clearance";"Post-translational protein phosphorylation";"Chylomicron clearance";"Chylomicron remodeling";"VLDL assembly";"Chylomicron assembly";"Scavenging by Class A Receptors";"Scavenging by Class H Receptors";"Scavenging by Class F Receptors";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"LDL remodeling";"Retinoid metabolism and transport";"VLDL clearance";"Regulation of TLR by endogenous ligand";"Scavenging by Class B Receptors";"Cell surface interactions at the vascular wall"
XP_046427866.1	3	KEGG: 00790+3.1.3.1;MetaCyc: PWY-5491;KEGG: 00730+3.1.3.1	"Folate biosynthesis";"Diethylphosphate degradation";"Thiamine metabolism"
XP_046431452.1	2	Reactome: R-HSA-3238698;Reactome: R-HSA-373080	"WNT ligand biogenesis and trafficking";"Class B/2 (Secretin family receptors)"
XP_046412354.1	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
XP_046420943.1	13	Reactome: R-HSA-6791226;Reactome: R-HSA-975957;Reactome: R-HSA-72764;Reactome: R-HSA-975956;Reactome: R-HSA-156902;Reactome: R-HSA-192823;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-72689;Reactome: R-HSA-1799339;Reactome: R-HSA-2408557;Reactome: R-HSA-72706	"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Peptide chain elongation";"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Formation of a pool of free 40S subunits";"SRP-dependent cotranslational protein targeting to membrane";"Selenocysteine synthesis";"GTP hydrolysis and joining of the 60S ribosomal subunit"
XP_046430200.1	2	Reactome: R-HSA-3928665;Reactome: R-HSA-2682334	"EPH-ephrin mediated repulsion of cells";"EPH-Ephrin signaling"
XP_046425287.1	17	KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;Reactome: R-HSA-3371453;KEGG: 04926+2.7.11.1;Reactome: R-HSA-69473;Reactome: R-HSA-6804756;KEGG: 05163+2.7.11.1;Reactome: R-HSA-176187;Reactome: R-HSA-6796648;KEGG: 04151+2.7.11.1;Reactome: R-HSA-5693616;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;Reactome: R-HSA-5693607;Reactome: R-HSA-1221632;Reactome: R-HSA-6783310;Reactome: R-HSA-5685938	"Human immunodeficiency virus 1 infection";"Thermogenesis";"Regulation of HSF1-mediated heat shock response";"Relaxin signaling pathway";"G2/M DNA damage checkpoint";"Regulation of TP53 Activity through Phosphorylation";"Human cytomegalovirus infection";"Activation of ATR in response to replication stress";"TP53 Regulates Transcription of DNA Repair Genes";"PI3K-Akt signaling pathway";"Presynaptic phase of homologous DNA pairing and strand exchange";"mTOR signaling pathway";"Human papillomavirus infection";"Processing of DNA double-strand break ends";"Meiotic synapsis";"Fanconi Anemia Pathway";"HDR through Single Strand Annealing (SSA)"
XP_046424476.1	6	MetaCyc: PWY-7782;MetaCyc: PWY-5884;KEGG: 00073+1.2.1.84;MetaCyc: PWY-7656;Reactome: R-HSA-9640463;MetaCyc: PWY-6733	"Plasmalogen biosynthesis";"Wax esters biosynthesis I";"Cutin, suberine and wax biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Wax biosynthesis";"Sporopollenin precursors biosynthesis"
XP_046410635.1	7	Reactome: R-HSA-5696400;Reactome: R-HSA-5685939;Reactome: R-HSA-3108214;Reactome: R-HSA-5696394;Reactome: R-HSA-5696395;Reactome: R-HSA-2173795;Reactome: R-HSA-110362	"Dual Incision in GG-NER";"HDR through MMEJ (alt-NHEJ)";"SUMOylation of DNA damage response and repair proteins";"DNA Damage Recognition in GG-NER";"Formation of Incision Complex in GG-NER";"Downregulation of SMAD2/3:SMAD4 transcriptional activity";"POLB-Dependent Long Patch Base Excision Repair"
XP_046426075.1	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
XP_046416007.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_046416951.1	1	Reactome: R-HSA-9037629	"Lewis blood group biosynthesis"
XP_046415442.1	6	Reactome: R-HSA-77588;Reactome: R-HSA-73856;Reactome: R-HSA-72165;Reactome: R-HSA-111367;Reactome: R-HSA-72163;Reactome: R-HSA-191859	"SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs";"RNA Polymerase II Transcription Termination";"mRNA Splicing - Minor Pathway";"SLBP independent Processing of Histone Pre-mRNAs";"mRNA Splicing - Major Pathway";"snRNP Assembly"
XP_046416187.1	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
XP_046433936.1	4	KEGG: 00790+4.1.99.22;MetaCyc: PWY-6823;KEGG: 00790+4.6.1.17;Reactome: R-HSA-947581	"Folate biosynthesis";"Molybdenum cofactor biosynthesis";"Folate biosynthesis";"Molybdenum cofactor biosynthesis"
XP_046436630.1	3	Reactome: R-HSA-4086398;Reactome: R-HSA-392517;Reactome: R-HSA-418457	"Ca2+ pathway";"Rap1 signalling";"cGMP effects"
XP_046416609.1	5	MetaCyc: PWY-7918;Reactome: R-HSA-4793954;Reactome: R-HSA-532668;MetaCyc: PWY-7919;KEGG: 00510+3.2.1.106	"Protein N-glycosylation processing phase (yeast)";"Defective MOGS causes MOGS-CDG (CDG-2b)";"N-glycan trimming in the ER and Calnexin/Calreticulin cycle";"Protein N-glycosylation processing phase (plants and animals)";"N-Glycan biosynthesis"
XP_046417001.1	5	KEGG: 00531+3.1.6.14;Reactome: R-HSA-2022857;Reactome: R-HSA-6798695;Reactome: R-HSA-2206305;Reactome: R-HSA-432720	"Glycosaminoglycan degradation";"Keratan sulfate degradation";"Neutrophil degranulation";"MPS IIID - Sanfilippo syndrome D";"Lysosome Vesicle Biogenesis"
XP_046426966.1	16	Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-2408557;Reactome: R-HSA-72706;Reactome: R-HSA-6791226;Reactome: R-HSA-72702;Reactome: R-HSA-975956;Reactome: R-HSA-192823;Reactome: R-HSA-72689;Reactome: R-HSA-1799339;Reactome: R-HSA-72695;Reactome: R-HSA-975957;Reactome: R-HSA-72764;Reactome: R-HSA-72649;Reactome: R-HSA-156902	"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Selenocysteine synthesis";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Major pathway of rRNA processing in the nucleolus and cytosol";"Ribosomal scanning and start codon recognition";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Viral mRNA Translation";"Formation of a pool of free 40S subunits";"SRP-dependent cotranslational protein targeting to membrane";"Formation of the ternary complex, and subsequently, the 43S complex";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Translation initiation complex formation";"Peptide chain elongation"
XP_046409646.1	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
XP_046417541.1	2	Reactome: R-HSA-6798695;Reactome: R-HSA-936837	"Neutrophil degranulation";"Ion transport by P-type ATPases"
XP_046429837.1	2	Reactome: R-HSA-5635838;Reactome: R-HSA-5632681	"Activation of SMO";"Ligand-receptor interactions"
XP_046436507.1	2	Reactome: R-HSA-8853383;KEGG: 00511+3.2.1.24	"Lysosomal oligosaccharide catabolism";"Other glycan degradation"
XP_046428659.1	1	Reactome: R-HSA-197264	"Nicotinamide salvaging"
XP_046425101.1	11	Reactome: R-HSA-6804114;Reactome: R-HSA-1989781;Reactome: R-HSA-400206;Reactome: R-HSA-1368082;Reactome: R-HSA-400253;Reactome: R-HSA-9018519;Reactome: R-HSA-381340;Reactome: R-HSA-3214858;Reactome: R-HSA-1368108;Reactome: R-HSA-2426168;Reactome: R-HSA-2151201	"TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest";"PPARA activates gene expression";"Regulation of lipid metabolism by PPARalpha";"RORA activates gene expression";"Circadian Clock";"Estrogen-dependent gene expression";"Transcriptional regulation of white adipocyte differentiation";"RMTs methylate histone arginines";"BMAL1:CLOCK,NPAS2 activates circadian gene expression";"Activation of gene expression by SREBF (SREBP)";"Transcriptional activation of mitochondrial biogenesis"
XP_046410132.1	6	Reactome: R-HSA-1855183;Reactome: R-HSA-1660516;Reactome: R-HSA-1660499;KEGG: 04070+3.1.3.66;MetaCyc: PWY-6368;KEGG: 00562+3.1.3.66	"Synthesis of IP2, IP, and Ins in the cytosol";"Synthesis of PIPs at the early endosome membrane";"Synthesis of PIPs at the plasma membrane";"Phosphatidylinositol signaling system";"3-phosphoinositide degradation";"Inositol phosphate metabolism"
XP_046410716.1	2	Reactome: R-HSA-1236394;Reactome: R-HSA-977443	"Signaling by ERBB4";"GABA receptor activation"
XP_046435908.1	3	Reactome: R-HSA-379716;KEGG: 00970+6.1.1.5;Reactome: R-HSA-2408522	"Cytosolic tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis";"Selenoamino acid metabolism"
XP_046410702.1	3	MetaCyc: PWY-6700;Reactome: R-HSA-6782315;MetaCyc: PWY-8106	"Queuosine biosynthesis I (de novo)";"tRNA modification in the nucleus and cytosol";"Queuosine biosynthesis III (queuosine salvage)"
XP_046410569.1	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
XP_046412470.1	1	KEGG: 00970+6.3.5.7	"Aminoacyl-tRNA biosynthesis"
XP_046428513.1	2	KEGG: 00670+2.1.2.10;KEGG: 00260+2.1.2.10	"One carbon pool by folate";"Glycine, serine and threonine metabolism"
XP_046431103.1	13	MetaCyc: PWY-6728;MetaCyc: PWY-5913;MetaCyc: PWY-6969;KEGG: 00020+4.2.1.2;MetaCyc: PWY-7254;MetaCyc: PWY-8086;MetaCyc: PWY-561;MetaCyc: PWY-5392;MetaCyc: PWY-5690;MetaCyc: PWY-7384;Reactome: R-HSA-71403;KEGG: 00620+4.2.1.2;KEGG: 00720+4.2.1.2	"Methylaspartate cycle";"Partial TCA cycle (obligate autotrophs)";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Citrate cycle (TCA cycle)";"TCA cycle VII (acetate-producers)";"(S)-lactate fermentation to propanoate, acetate and hydrogen";"Superpathway of glyoxylate cycle and fatty acid degradation";"Reductive TCA cycle II";"TCA cycle II (plants and fungi)";"Anaerobic energy metabolism (invertebrates, mitochondrial)";"Citric acid cycle (TCA cycle)";"Pyruvate metabolism";"Carbon fixation pathways in prokaryotes"
XP_046430561.1	16	Reactome: R-HSA-192823;Reactome: R-HSA-72689;Reactome: R-HSA-1799339;Reactome: R-HSA-72695;Reactome: R-HSA-975957;Reactome: R-HSA-72764;Reactome: R-HSA-72649;Reactome: R-HSA-156902;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-2408557;Reactome: R-HSA-72706;Reactome: R-HSA-6791226;Reactome: R-HSA-72702;Reactome: R-HSA-975956	"Viral mRNA Translation";"Formation of a pool of free 40S subunits";"SRP-dependent cotranslational protein targeting to membrane";"Formation of the ternary complex, and subsequently, the 43S complex";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Translation initiation complex formation";"Peptide chain elongation";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Selenocysteine synthesis";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Major pathway of rRNA processing in the nucleolus and cytosol";"Ribosomal scanning and start codon recognition";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"
XP_046432110.1	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
XP_046424406.1	1	Reactome: R-HSA-8856828	"Clathrin-mediated endocytosis"
XP_046415229.1	4	Reactome: R-HSA-2470946;Reactome: R-HSA-2500257;Reactome: R-HSA-2468052;Reactome: R-HSA-2467813	"Cohesin Loading onto Chromatin";"Resolution of Sister Chromatid Cohesion";"Establishment of Sister Chromatid Cohesion";"Separation of Sister Chromatids"
XP_046412842.1	1	Reactome: R-HSA-216083	"Integrin cell surface interactions"
XP_046425949.1	29	Reactome: R-HSA-73779;Reactome: R-HSA-6782135;Reactome: R-HSA-6781827;Reactome: R-HSA-5696400;Reactome: R-HSA-167158;Reactome: R-HSA-73762;Reactome: R-HSA-167160;Reactome: R-HSA-6781823;Reactome: R-HSA-167246;Reactome: R-HSA-167162;Reactome: R-HSA-427413;Reactome: R-HSA-75953;Reactome: R-HSA-6782210;Reactome: R-HSA-113418;Reactome: R-HSA-167200;Reactome: R-HSA-6796648;Reactome: R-HSA-77075;Reactome: R-HSA-72086;Reactome: R-HSA-674695;Reactome: R-HSA-73776;Reactome: R-HSA-167161;Reactome: R-HSA-167152;Reactome: R-HSA-5696395;Reactome: R-HSA-73772;Reactome: R-HSA-167172;Reactome: R-HSA-75955;Reactome: R-HSA-76042;Reactome: R-HSA-73863;Reactome: R-HSA-112382	"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Dual incision in TC-NER";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Dual Incision in GG-NER";"Formation of the HIV-1 Early Elongation Complex";"RNA Polymerase I Transcription Initiation";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Formation of TC-NER Pre-Incision Complex";"Tat-mediated elongation of the HIV-1 transcript";"RNA Polymerase II HIV Promoter Escape";"NoRC negatively regulates rRNA expression";"RNA Polymerase II Transcription Initiation";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Formation of the Early Elongation Complex";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Pol II CTD phosphorylation and interaction with CE";"mRNA Capping";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Promoter Escape";"HIV Transcription Initiation";"Formation of HIV elongation complex in the absence of HIV Tat";"Formation of Incision Complex in GG-NER";"RNA Polymerase I Promoter Escape";"Transcription of the HIV genome";"RNA Polymerase II Transcription Elongation";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase I Transcription Termination";"Formation of RNA Pol II elongation complex"
XP_046436442.1	5	Reactome: R-HSA-2871796;KEGG: 04150+2.7.11.24;Reactome: R-HSA-450321;Reactome: R-HSA-2559580;Reactome: R-HSA-450341	"FCERI mediated MAPK activation";"mTOR signaling pathway";"JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1";"Oxidative Stress Induced Senescence";"Activation of the AP-1 family of transcription factors"
XP_046425311.1	1	Reactome: R-HSA-216083	"Integrin cell surface interactions"
XP_046431592.1	2	Reactome: R-HSA-5576893;Reactome: R-HSA-5576892	"Phase 2 - plateau phase";"Phase 0 - rapid depolarisation"
XP_046433383.1	3	Reactome: R-HSA-194840;Reactome: R-HSA-416482;Reactome: R-HSA-193648	"Rho GTPase cycle";"G alpha (12/13) signalling events";"NRAGE signals death through JNK"
XP_046427820.1	1	Reactome: R-HSA-1660661	"Sphingolipid de novo biosynthesis"
XP_046434907.1	4	Reactome: R-HSA-674695;Reactome: R-HSA-75955;Reactome: R-HSA-8866654;Reactome: R-HSA-112382	"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Elongation";"E3 ubiquitin ligases ubiquitinate target proteins";"Formation of RNA Pol II elongation complex"
XP_046425745.1	13	Reactome: R-HSA-6791226;Reactome: R-HSA-975957;Reactome: R-HSA-72764;Reactome: R-HSA-975956;Reactome: R-HSA-156902;Reactome: R-HSA-192823;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-72689;Reactome: R-HSA-1799339;Reactome: R-HSA-2408557;Reactome: R-HSA-72706	"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Peptide chain elongation";"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Formation of a pool of free 40S subunits";"SRP-dependent cotranslational protein targeting to membrane";"Selenocysteine synthesis";"GTP hydrolysis and joining of the 60S ribosomal subunit"
XP_046411097.1	2	Reactome: R-HSA-6784531;Reactome: R-HSA-6791226	"tRNA processing in the nucleus";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046411877.1	1	Reactome: R-HSA-5221030	"TET1,2,3 and TDG demethylate DNA"
XP_046433239.1	1	Reactome: R-HSA-3295583	"TRP channels"
XP_046418440.1	1	Reactome: R-HSA-3238698	"WNT ligand biogenesis and trafficking"
XP_046412894.1	13	MetaCyc: PWY-7112;MetaCyc: PWY-4061;KEGG: 00983+2.5.1.18;MetaCyc: PWY-2261;KEGG: 00982+2.5.1.18;MetaCyc: PWY-6370;Reactome: R-HSA-156590;KEGG: 00053+1.8.5.1;Reactome: R-HSA-196836;MetaCyc: PWY-7533;KEGG: 00980+2.5.1.18;MetaCyc: PWY-6842;KEGG: 00480+2.5.1.18+1.8.5.1	"4-hydroxy-2-nonenal detoxification";"Glutathione-mediated detoxification I";"Drug metabolism - other enzymes";"Ascorbate glutathione cycle";"Drug metabolism - cytochrome P450";"Ascorbate recycling (cytosolic)";"Glutathione conjugation";"Ascorbate and aldarate metabolism";"Vitamin C (ascorbate) metabolism";"Gliotoxin biosynthesis";"Metabolism of xenobiotics by cytochrome P450";"Glutathione-mediated detoxification II";"Glutathione metabolism"
XP_046436308.1	4	Reactome: R-HSA-6798163;KEGG: 00260+1.2.1.8+1.1.99.1;MetaCyc: PWY-3722;MetaCyc: PWY-7494	"Choline catabolism";"Glycine, serine and threonine metabolism";"Glycine betaine biosynthesis II (Gram-positive bacteria)";"Choline degradation IV"
XP_046409360.1	3	Reactome: R-HSA-74259;Reactome: R-HSA-73621;Reactome: R-HSA-196807	"Purine catabolism";"Pyrimidine catabolism";"Nicotinate metabolism"
XP_046414042.1	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
XP_046429296.1	1	Reactome: R-HSA-400253	"Circadian Clock"
XP_046416695.1	6	Reactome: R-HSA-4411364;Reactome: R-HSA-4086398;Reactome: R-HSA-3769402;Reactome: R-HSA-4641265;Reactome: R-HSA-201722;Reactome: R-HSA-8951430	"Binding of TCF/LEF:CTNNB1 to target gene promoters";"Ca2+ pathway";"Deactivation of the beta-catenin transactivating complex";"Repression of WNT target genes";"Formation of the beta-catenin:TCF transactivating complex";"RUNX3 regulates WNT signaling"
XP_046427443.1	5	Reactome: R-HSA-6814122;Reactome: R-HSA-389957;Reactome: R-HSA-389960;Reactome: R-HSA-390471;Reactome: R-HSA-390450	"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"Prefoldin mediated transfer of substrate to CCT/TriC";"Formation of tubulin folding intermediates by CCT/TriC";"Association of TriC/CCT with target proteins during biosynthesis";"Folding of actin by CCT/TriC"
XP_046430770.1	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
XP_046420762.1	13	MetaCyc: PWY-7220;KEGG: 00983+1.17.4.1;KEGG: 00230+1.17.4.1;KEGG: 00480+1.17.4.1;MetaCyc: PWY-7226;MetaCyc: PWY-7198;MetaCyc: PWY-7227;Reactome: R-HSA-499943;MetaCyc: PWY-7210;MetaCyc: PWY-7184;MetaCyc: PWY-7222;KEGG: 00240+1.17.4.1;MetaCyc: PWY-6545	"Adenosine deoxyribonucleotides de novo biosynthesis II";"Drug metabolism - other enzymes";"Purine metabolism";"Glutathione metabolism";"Guanosine deoxyribonucleotides de novo biosynthesis I";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Adenosine deoxyribonucleotides de novo biosynthesis";"Interconversion of nucleotide di- and triphosphates";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Guanosine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis III"
XP_046415071.1	10	Reactome: R-HSA-913709;MetaCyc: PWY-7922;Reactome: R-HSA-4717374;MetaCyc: PWY-7661;Reactome: R-HSA-4719360;MetaCyc: PWY-7921;KEGG: 00510+2.4.1.83;MetaCyc: PWY-7979;Reactome: R-HSA-162699;Reactome: R-HSA-4719377	"O-linked glycosylation of mucins";"Protein O-mannosylation II (mammals, core M1 and core M2)";"Defective DPM1 causes DPM1-CDG (CDG-1e)";"Protein N-glycosylation (Haloferax volcanii)";"Defective DPM3 causes DPM3-CDG (CDG-1o)";"Protein O-mannosylation I (yeast)";"N-Glycan biosynthesis";"Protein O-mannosylation III (mammals, core M3)";"Synthesis of dolichyl-phosphate mannose";"Defective DPM2 causes DPM2-CDG (CDG-1u)"
XP_046413117.1	3	Reactome: R-HSA-390471;Reactome: R-HSA-8951664;Reactome: R-HSA-983168	"Association of TriC/CCT with target proteins during biosynthesis";"Neddylation";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046419358.1	2	Reactome: R-HSA-5578999;Reactome: R-HSA-174403	"Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD)";"Glutathione synthesis and recycling"
XP_046409490.1	7	Reactome: R-HSA-6798695;MetaCyc: PWY-7221;MetaCyc: PWY-5695;MetaCyc: PWY-6596;KEGG: 00230+1.1.1.205;Reactome: R-HSA-73817;KEGG: 00983+1.1.1.205	"Neutrophil degranulation";"Guanosine ribonucleotides de novo biosynthesis";"Inosine 5'-phosphate degradation";"Adenosine nucleotides degradation I";"Purine metabolism";"Purine ribonucleoside monophosphate biosynthesis";"Drug metabolism - other enzymes"
XP_046409770.1	12	KEGG: 05163+2.7.11.1;Reactome: R-HSA-416476;Reactome: R-HSA-193648;KEGG: 04926+2.7.11.1;Reactome: R-HSA-418885;KEGG: 04150+2.7.11.1;Reactome: R-HSA-416482;KEGG: 04151+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;Reactome: R-HSA-194840	"Human cytomegalovirus infection";"G alpha (q) signalling events";"NRAGE signals death through JNK";"Relaxin signaling pathway";"DCC mediated attractive signaling";"mTOR signaling pathway";"G alpha (12/13) signalling events";"PI3K-Akt signaling pathway";"Thermogenesis";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Rho GTPase cycle"
XP_046418878.1	1	Reactome: R-HSA-212436	"Generic Transcription Pathway"
XP_046431561.1	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
XP_046428183.1	3	Reactome: R-HSA-425561;Reactome: R-HSA-418359;Reactome: R-HSA-5578775	"Sodium/Calcium exchangers";"Reduction of cytosolic Ca++ levels";"Ion homeostasis"
XP_046427500.1	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
XP_046419687.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_046420051.1	1	Reactome: R-HSA-3214842	"HDMs demethylate histones"
XP_046411080.1	3	Reactome: R-HSA-1989781;Reactome: R-HSA-381340;Reactome: R-HSA-9018519	"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation";"Estrogen-dependent gene expression"
XP_046426456.1	6	Reactome: R-HSA-5663220;Reactome: R-HSA-2500257;Reactome: R-HSA-68877;Reactome: R-HSA-2467813;Reactome: R-HSA-9648025;Reactome: R-HSA-141444	"RHO GTPases Activate Formins";"Resolution of Sister Chromatid Cohesion";"Mitotic Prometaphase";"Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"
XP_046419512.1	3	Reactome: R-HSA-3000157;Reactome: R-HSA-8874081;Reactome: R-HSA-3000171	"Laminin interactions";"MET activates PTK2 signaling";"Non-integrin membrane-ECM interactions"
XP_046420359.1	2	Reactome: R-HSA-5689603;Reactome: R-HSA-5696394	"UCH proteinases";"DNA Damage Recognition in GG-NER"
XP_046435917.1	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
XP_046435683.1	7	Reactome: R-HSA-429947;Reactome: R-HSA-72649;Reactome: R-HSA-72662;Reactome: R-HSA-72706;Reactome: R-HSA-72702;Reactome: R-HSA-156827;Reactome: R-HSA-166208	"Deadenylation of mRNA";"Translation initiation complex formation";"Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Ribosomal scanning and start codon recognition";"L13a-mediated translational silencing of Ceruloplasmin expression";"mTORC1-mediated signalling"
XP_046410719.1	2	Reactome: R-HSA-977443;Reactome: R-HSA-1236394	"GABA receptor activation";"Signaling by ERBB4"
XP_046430143.1	4	Reactome: R-HSA-400511;Reactome: R-HSA-1799339;Reactome: R-HSA-422085;Reactome: R-HSA-381771	"Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)";"SRP-dependent cotranslational protein targeting to membrane";"Synthesis, secretion, and deacylation of Ghrelin";"Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)"
XP_046415418.1	2	Reactome: R-HSA-5578998;Reactome: R-HSA-174403	"Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD)";"Glutathione synthesis and recycling"
XP_046412850.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046424593.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046436319.1	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
XP_046421525.1	3	Reactome: R-HSA-192456;MetaCyc: PWY-6857;KEGG: 00561+3.1.1.3	"Digestion of dietary lipid";"Retinol biosynthesis";"Glycerolipid metabolism"
XP_046424333.1	4	Reactome: R-HSA-2243919;Reactome: R-HSA-1650814;Reactome: R-HSA-1474228;Reactome: R-HSA-2214320	"Crosslinking of collagen fibrils";"Collagen biosynthesis and modifying enzymes";"Degradation of the extracellular matrix";"Anchoring fibril formation"
XP_046413588.1	10	MetaCyc: PWY-7385;MetaCyc: PWY-1042;KEGG: 00680+2.7.1.11;KEGG: 00010+2.7.1.11;Reactome: R-HSA-70171;MetaCyc: PWY-1861;MetaCyc: PWY-5484;KEGG: 00052+2.7.1.11;KEGG: 00051+2.7.1.11;KEGG: 00030+2.7.1.11	"1,3-propanediol biosynthesis (engineered)";"Glycolysis IV (plant cytosol)";"Methane metabolism";"Glycolysis / Gluconeogenesis";"Glycolysis";"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"Glycolysis II (from fructose 6-phosphate)";"Galactose metabolism";"Fructose and mannose metabolism";"Pentose phosphate pathway"
XP_046436217.1	2	Reactome: R-HSA-3238698;Reactome: R-HSA-373080	"WNT ligand biogenesis and trafficking";"Class B/2 (Secretin family receptors)"
XP_046412378.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_046429751.1	7	Reactome: R-HSA-5083633;Reactome: R-HSA-3000171;Reactome: R-HSA-9010553;Reactome: R-HSA-5083629;Reactome: R-HSA-5173105;Reactome: R-HSA-3000178;Reactome: R-HSA-5083628	"Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1";"Non-integrin membrane-ECM interactions";"Regulation of expression of SLITs and ROBOs";"Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2";"O-linked glycosylation";"ECM proteoglycans";"Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3"
XP_046435745.1	2	Reactome: R-HSA-416476;Reactome: R-HSA-380095	"G alpha (q) signalling events";"Tachykinin receptors bind tachykinins"
XP_046411938.1	13	MetaCyc: PWY-6545;KEGG: 00240+1.17.4.1;MetaCyc: PWY-7222;MetaCyc: PWY-7184;MetaCyc: PWY-7210;Reactome: R-HSA-499943;MetaCyc: PWY-7198;MetaCyc: PWY-7227;MetaCyc: PWY-7226;KEGG: 00480+1.17.4.1;KEGG: 00230+1.17.4.1;KEGG: 00983+1.17.4.1;MetaCyc: PWY-7220	"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Pyrimidine metabolism";"Guanosine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Interconversion of nucleotide di- and triphosphates";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Adenosine deoxyribonucleotides de novo biosynthesis";"Guanosine deoxyribonucleotides de novo biosynthesis I";"Glutathione metabolism";"Purine metabolism";"Drug metabolism - other enzymes";"Adenosine deoxyribonucleotides de novo biosynthesis II"
XP_046420354.1	6	Reactome: R-HSA-204005;Reactome: R-HSA-416993;Reactome: R-HSA-6811434;Reactome: R-HSA-6811438;Reactome: R-HSA-6811440;Reactome: R-HSA-6807878	"COPII-mediated vesicle transport";"Trafficking of GluR2-containing AMPA receptors";"COPI-dependent Golgi-to-ER retrograde traffic";"Intra-Golgi traffic";"Retrograde transport at the Trans-Golgi-Network";"COPI-mediated anterograde transport"
XP_046416505.1	2	KEGG: 00670+2.1.2.10;KEGG: 00260+2.1.2.10	"One carbon pool by folate";"Glycine, serine and threonine metabolism"
XP_046427736.1	2	Reactome: R-HSA-6790901;Reactome: R-HSA-171319	"rRNA modification in the nucleus and cytosol";"Telomere Extension By Telomerase"
XP_046427695.1	7	Reactome: R-HSA-9648025;Reactome: R-HSA-141444;Reactome: R-HSA-606279;Reactome: R-HSA-68877;Reactome: R-HSA-2467813;Reactome: R-HSA-5663220;Reactome: R-HSA-2500257	"EML4 and NUDC in mitotic spindle formation";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Deposition of new CENPA-containing nucleosomes at the centromere";"Mitotic Prometaphase";"Separation of Sister Chromatids";"RHO GTPases Activate Formins";"Resolution of Sister Chromatid Cohesion"
XP_046417822.1	7	Reactome: R-HSA-1855183;KEGG: 04070+3.1.3.25;KEGG: 00562+3.1.3.25;KEGG: 00521+3.1.3.25;MetaCyc: PWY-6363;MetaCyc: PWY-4702;MetaCyc: PWY-2301	"Synthesis of IP2, IP, and Ins in the cytosol";"Phosphatidylinositol signaling system";"Inositol phosphate metabolism";"Streptomycin biosynthesis";"D-myo-inositol (1,4,5)-trisphosphate degradation";"Phytate degradation I";"Myo-inositol biosynthesis"
XP_046434221.1	1	Reactome: R-HSA-5662702	"Melanin biosynthesis"
XP_046433085.1	3	Reactome: R-HSA-202427;Reactome: R-HSA-6807004;Reactome: R-HSA-6798695	"Phosphorylation of CD3 and TCR zeta chains";"Negative regulation of MET activity";"Neutrophil degranulation"
XP_046428852.1	6	Reactome: R-HSA-912446;Reactome: R-HSA-5632987;Reactome: R-HSA-6796648;Reactome: R-HSA-5358565;Reactome: R-HSA-5545483;Reactome: R-HSA-5358606	"Meiotic recombination";"Defective Mismatch Repair Associated With PMS2";"TP53 Regulates Transcription of DNA Repair Genes";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"Defective Mismatch Repair Associated With MLH1";"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)"
XP_046411015.1	5	Reactome: R-HSA-1632852;Reactome: R-HSA-5628897;Reactome: R-HSA-380972;Reactome: R-HSA-8854214;Reactome: R-HSA-165181	"Macroautophagy";"TP53 Regulates Metabolic Genes";"Energy dependent regulation of mTOR by LKB1-AMPK";"TBC/RABGAPs";"Inhibition of TSC complex formation by PKB"
XP_046431657.1	1	Reactome: R-HSA-435368	"Zinc efflux and compartmentalization by the SLC30 family"
XP_046411086.1	3	Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-9018519	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"Estrogen-dependent gene expression"
XP_046409608.1	9	KEGG: 00710+1.2.1.12;MetaCyc: PWY-7003;Reactome: R-HSA-70171;KEGG: 00010+1.2.1.12;MetaCyc: PWY-5484;MetaCyc: PWY-1042;MetaCyc: PWY-8004;MetaCyc: PWY-6901;Reactome: R-HSA-70263	"Carbon fixation in photosynthetic organisms";"Glycerol degradation to butanol";"Glycolysis";"Glycolysis / Gluconeogenesis";"Glycolysis II (from fructose 6-phosphate)";"Glycolysis IV (plant cytosol)";"Entner-Doudoroff pathway I";"Superpathway of glucose and xylose degradation";"Gluconeogenesis"
XP_046416382.1	2	Reactome: R-HSA-5576893;Reactome: R-HSA-5576892	"Phase 2 - plateau phase";"Phase 0 - rapid depolarisation"
XP_046416546.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046412348.1	1	Reactome: R-HSA-71064	"Lysine catabolism"
XP_046417820.1	7	MetaCyc: PWY-4702;MetaCyc: PWY-2301;MetaCyc: PWY-6363;KEGG: 00521+3.1.3.25;KEGG: 00562+3.1.3.25;Reactome: R-HSA-1855183;KEGG: 04070+3.1.3.25	"Phytate degradation I";"Myo-inositol biosynthesis";"D-myo-inositol (1,4,5)-trisphosphate degradation";"Streptomycin biosynthesis";"Inositol phosphate metabolism";"Synthesis of IP2, IP, and Ins in the cytosol";"Phosphatidylinositol signaling system"
XP_046431550.1	2	MetaCyc: PWY-6281;KEGG: 00970+6.1.1.11	"L-selenocysteine biosynthesis II (archaea and eukaryotes)";"Aminoacyl-tRNA biosynthesis"
XP_046414961.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_046413109.1	1	Reactome: R-HSA-1632852	"Macroautophagy"
XP_046432184.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_046429498.1	5	KEGG: 05235+3.1.3.16;Reactome: R-HSA-176407;KEGG: 04658+3.1.3.16;Reactome: R-HSA-5687128;KEGG: 04660+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"Th1 and Th2 cell differentiation";"MAPK6/MAPK4 signaling";"T cell receptor signaling pathway"
XP_046421388.1	3	Reactome: R-HSA-1474151;Reactome: R-HSA-203615;KEGG: 00790+1.1.1.153	"Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation";"eNOS activation";"Folate biosynthesis"
XP_046411241.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046417757.1	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
XP_046428977.1	2	Reactome: R-HSA-8866654;Reactome: R-HSA-9033241	"E3 ubiquitin ligases ubiquitinate target proteins";"Peroxisomal protein import"
XP_046427629.1	6	Reactome: R-HSA-8950505;MetaCyc: PWY-6854;Reactome: R-HSA-3299685;Reactome: R-HSA-8862803;Reactome: R-HSA-2151201;Reactome: R-HSA-9615017	"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation";"Ethylene biosynthesis III (microbes)";"Detoxification of Reactive Oxygen Species";"Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models";"Transcriptional activation of mitochondrial biogenesis";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes"
XP_046432090.1	7	KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1	"Human cytomegalovirus infection";"Thermogenesis";"Relaxin signaling pathway";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"mTOR signaling pathway"
XP_046419000.1	2	Reactome: R-HSA-5357956;Reactome: R-HSA-5357905	"TNFR1-induced NFkappaB signaling pathway";"Regulation of TNFR1 signaling"
XP_046423689.1	1	KEGG: 00970+6.1.1.7	"Aminoacyl-tRNA biosynthesis"
XP_046418347.1	1	Reactome: R-HSA-9022692	"Regulation of MECP2 expression and activity"
XP_046426200.1	2	Reactome: R-HSA-2299718;Reactome: R-HSA-2514853	"Condensation of Prophase Chromosomes";"Condensation of Prometaphase Chromosomes"
XP_046435698.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046418257.1	1	Reactome: R-HSA-110357	"Displacement of DNA glycosylase by APEX1"
XP_046434318.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_046428474.1	3	Reactome: R-HSA-6798695;Reactome: R-HSA-2024096;Reactome: R-HSA-2206291	"Neutrophil degranulation";"HS-GAG degradation";"MPS IIIC - Sanfilippo syndrome C"
XP_046426946.1	6	Reactome: R-HSA-6798695;KEGG: 00511+3.2.1.25;Reactome: R-HSA-2024096;Reactome: R-HSA-2160916;Reactome: R-HSA-8853383;Reactome: R-HSA-2206292	"Neutrophil degranulation";"Other glycan degradation";"HS-GAG degradation";"Hyaluronan uptake and degradation";"Lysosomal oligosaccharide catabolism";"MPS VII - Sly syndrome"
XP_046419579.1	2	Reactome: R-HSA-9603798;Reactome: R-HSA-1369062	"Class I peroxisomal membrane protein import";"ABC transporters in lipid homeostasis"
XP_046434993.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046435668.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-5628897	"Respiratory electron transport";"TP53 Regulates Metabolic Genes"
XP_046424630.1	4	Reactome: R-HSA-212300;Reactome: R-HSA-5334118;KEGG: 00270+2.1.1.37;Reactome: R-HSA-4655427	"PRC2 methylates histones and DNA";"DNA methylation";"Cysteine and methionine metabolism";"SUMOylation of DNA methylation proteins"
XP_046415703.1	2	Reactome: R-HSA-5576892;Reactome: R-HSA-445095	"Phase 0 - rapid depolarisation";"Interaction between L1 and Ankyrins"
XP_046425783.1	2	MetaCyc: PWY-6854;Reactome: R-HSA-3299685	"Ethylene biosynthesis III (microbes)";"Detoxification of Reactive Oxygen Species"
XP_046421975.1	2	Reactome: R-HSA-418457;Reactome: R-HSA-1296052	"cGMP effects";"Ca2+ activated K+ channels"
XP_046415585.1	1	Reactome: R-HSA-433137	"Sodium-coupled sulphate, di- and tri-carboxylate transporters"
XP_046428544.1	1	Reactome: R-HSA-1632852	"Macroautophagy"
XP_046411206.1	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
XP_046413337.1	5	KEGG: 00520+2.7.1.6;KEGG: 00052+2.7.1.6;MetaCyc: PWY-6527;MetaCyc: PWY-6317;MetaCyc: PWY-3821	"Amino sugar and nucleotide sugar metabolism";"Galactose metabolism";"Stachyose degradation";"D-galactose degradation I (Leloir pathway)";"D-galactose detoxification"
XP_046431711.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046420934.1	3	Reactome: R-HSA-212436;Reactome: R-HSA-381340;Reactome: R-HSA-1989781	"Generic Transcription Pathway";"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression"
XP_046425774.1	20	Reactome: R-HSA-5656121;Reactome: R-HSA-5696397;Reactome: R-HSA-110314;Reactome: R-HSA-69091;Reactome: R-HSA-5655862;Reactome: R-HSA-5656169;Reactome: R-HSA-176187;Reactome: R-HSA-5693616;Reactome: R-HSA-6804756;Reactome: R-HSA-69473;Reactome: R-HSA-5685942;Reactome: R-HSA-5693607;Reactome: R-HSA-6782210;Reactome: R-HSA-5685938;Reactome: R-HSA-5696400;Reactome: R-HSA-6782135;Reactome: R-HSA-110320;Reactome: R-HSA-5651801;Reactome: R-HSA-174411;Reactome: R-HSA-110312	"Translesion synthesis by POLI";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Recognition of DNA damage by PCNA-containing replication complex";"Polymerase switching";"Translesion synthesis by POLK";"Termination of translesion DNA synthesis";"Activation of ATR in response to replication stress";"Presynaptic phase of homologous DNA pairing and strand exchange";"Regulation of TP53 Activity through Phosphorylation";"G2/M DNA damage checkpoint";"HDR through Homologous Recombination (HRR)";"Processing of DNA double-strand break ends";"Gap-filling DNA repair synthesis and ligation in TC-NER";"HDR through Single Strand Annealing (SSA)";"Dual Incision in GG-NER";"Dual incision in TC-NER";"Translesion Synthesis by POLH";"PCNA-Dependent Long Patch Base Excision Repair";"Polymerase switching on the C-strand of the telomere";"Translesion synthesis by REV1"
XP_046416502.1	2	KEGG: 00670+2.1.2.10;KEGG: 00260+2.1.2.10	"One carbon pool by folate";"Glycine, serine and threonine metabolism"
XP_046427469.1	3	KEGG: 00250+3.5.1.1;KEGG: 00460+3.5.1.1;Reactome: R-HSA-8963693	"Alanine, aspartate and glutamate metabolism";"Cyanoamino acid metabolism";"Aspartate and asparagine metabolism"
XP_046428322.1	3	KEGG: 00790+3.1.3.1;MetaCyc: PWY-5491;KEGG: 00730+3.1.3.1	"Folate biosynthesis";"Diethylphosphate degradation";"Thiamine metabolism"
XP_046435199.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_046416508.1	7	KEGG: 00250+2.4.2.14;MetaCyc: PWY-6277;Reactome: R-HSA-73817;MetaCyc: PWY-6122;KEGG: 00230+2.4.2.14;MetaCyc: PWY-6121;MetaCyc: PWY-7282	"Alanine, aspartate and glutamate metabolism";"Superpathway of 5-aminoimidazole ribonucleotide biosynthesis";"Purine ribonucleoside monophosphate biosynthesis";"5-aminoimidazole ribonucleotide biosynthesis II";"Purine metabolism";"5-aminoimidazole ribonucleotide biosynthesis I";"4-amino-2-methyl-5-phosphomethylpyrimidine biosynthesis"
XP_046419842.1	5	Reactome: R-HSA-446210;KEGG: 00520+2.6.1.16;KEGG: 00250+2.6.1.16;MetaCyc: PWY-6749;MetaCyc: PWY-8013	"Synthesis of UDP-N-acetyl-glucosamine";"Amino sugar and nucleotide sugar metabolism";"Alanine, aspartate and glutamate metabolism";"CMP-legionaminate biosynthesis I";"UDP-N-acetyl-D-galactosamine biosynthesis III"
XP_046413398.1	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
XP_046428464.1	1	Reactome: R-HSA-5610787	"Hedgehog 'off' state"
XP_046429057.1	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
XP_046428548.1	5	Reactome: R-HSA-499943;KEGG: 00230+2.7.4.3;MetaCyc: PWY-7219;KEGG: 00230+2.7.4.10;KEGG: 00730+2.7.4.3	"Interconversion of nucleotide di- and triphosphates";"Purine metabolism";"Adenosine ribonucleotides de novo biosynthesis";"Purine metabolism";"Thiamine metabolism"
XP_046427337.1	2	KEGG: 00520+2.4.1.16;MetaCyc: PWY-6981	"Amino sugar and nucleotide sugar metabolism";"Chitin biosynthesis"
XP_046422934.1	1	Reactome: R-HSA-6799198	"Complex I biogenesis"
XP_046424308.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_046421024.1	6	MetaCyc: PWY-7656;KEGG: 00073+1.2.1.84;MetaCyc: PWY-6733;Reactome: R-HSA-9640463;MetaCyc: PWY-5884;MetaCyc: PWY-7782	"Spodoptera littoralis pheromone biosynthesis";"Cutin, suberine and wax biosynthesis";"Sporopollenin precursors biosynthesis";"Wax biosynthesis";"Wax esters biosynthesis I";"Plasmalogen biosynthesis"
XP_046413620.1	1	Reactome: R-HSA-6809371	"Formation of the cornified envelope"
XP_046418718.1	3	KEGG: 04660+2.7.10.2;Reactome: R-HSA-391160;Reactome: R-HSA-4420097	"T cell receptor signaling pathway";"Signal regulatory protein family interactions";"VEGFA-VEGFR2 Pathway"
XP_046412705.1	3	Reactome: R-HSA-73856;Reactome: R-HSA-72187;Reactome: R-HSA-159236	"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing";"Transport of Mature mRNA derived from an Intron-Containing Transcript"
XP_046412177.1	2	Reactome: R-HSA-6811434;Reactome: R-HSA-6798695	"COPI-dependent Golgi-to-ER retrograde traffic";"Neutrophil degranulation"
XP_046435517.1	2	Reactome: R-HSA-3214847;Reactome: R-HSA-6804758	"HATs acetylate histones";"Regulation of TP53 Activity through Acetylation"
XP_046430999.1	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
XP_046415062.1	1	Reactome: R-HSA-2132295	"MHC class II antigen presentation"
XP_046431363.1	18	Reactome: R-HSA-9633012;Reactome: R-HSA-166208;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-2408557;Reactome: R-HSA-72706;Reactome: R-HSA-6791226;Reactome: R-HSA-6790901;Reactome: R-HSA-975956;Reactome: R-HSA-72702;Reactome: R-HSA-72689;Reactome: R-HSA-192823;Reactome: R-HSA-72695;Reactome: R-HSA-1799339;Reactome: R-HSA-975957;Reactome: R-HSA-156902;Reactome: R-HSA-72764;Reactome: R-HSA-72649	"Response of EIF2AK4 (GCN2) to amino acid deficiency";"mTORC1-mediated signalling";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Selenocysteine synthesis";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Ribosomal scanning and start codon recognition";"Formation of a pool of free 40S subunits";"Viral mRNA Translation";"Formation of the ternary complex, and subsequently, the 43S complex";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Peptide chain elongation";"Eukaryotic Translation Termination";"Translation initiation complex formation"
XP_046413295.1	4	Reactome: R-HSA-4641257;Reactome: R-HSA-5689880;Reactome: R-HSA-201681;Reactome: R-HSA-418594	"Degradation of AXIN";"Ub-specific processing proteases";"TCF dependent signaling in response to WNT";"G alpha (i) signalling events"
XP_046426012.1	20	MetaCyc: PWY-6920;MetaCyc: PWY-7291;MetaCyc: PWY-7858;MetaCyc: PWY-7338;KEGG: 00071+1.3.3.6;MetaCyc: PWY-6837;KEGG: 00640+1.3.3.6;KEGG: 00592+1.3.3.6;MetaCyc: PWY-735;MetaCyc: PWY-5136;Reactome: R-HSA-9033241;KEGG: 00410+1.3.3.6;MetaCyc: PWY-7007;MetaCyc: PWY-7854;MetaCyc: PWY-7726;MetaCyc: PWY-7606;MetaCyc: PWY-7340;MetaCyc: PWY-7288;MetaCyc: PWY-7337;MetaCyc: PWY-7574	"6-gingerol analog biosynthesis (engineered)";"Oleate beta-oxidation (isomerase-dependent, yeast)";"(5Z)-dodecenoate biosynthesis II";"10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast)";"Fatty acid degradation";"Fatty acid beta-oxidation V (unsaturated, odd number, di-isomerase-dependent)";"Propanoate metabolism";"alpha-Linolenic acid metabolism";"Jasmonic acid biosynthesis";"Fatty acid beta-oxidation II (plant peroxisome)";"Peroxisomal protein import";"beta-Alanine metabolism";"Methyl ketone biosynthesis (engineered)";"Crotonyl-coa/ethylmalonyl-coa/hydroxybutyryl-coa cycle (engineered)";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast)";"Fatty acid beta-oxidation VII (yeast peroxisome)";"10-cis-heptadecenoyl-CoA degradation (yeast)";"Propanoyl-coa degradation II"
XP_046415770.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_046432932.1	1	Reactome: R-HSA-110362	"POLB-Dependent Long Patch Base Excision Repair"
XP_046416828.1	14	KEGG: 00591+3.1.1.4;MetaCyc: PWY-7417;MetaCyc: PWY-7409;MetaCyc: PWY-8053;MetaCyc: PWY-7416;Reactome: R-HSA-975634;KEGG: 00590+3.1.1.4;MetaCyc: PWY-7783;KEGG: 00592+3.1.1.4;KEGG: 00564+3.1.1.4+3.1.1.5;MetaCyc: PWY-8051;Reactome: R-HSA-1482788;MetaCyc: PWY-6803;KEGG: 00565+3.1.1.4	"Linoleic acid metabolism";"Phospholipid remodeling (phosphatidate, yeast)";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Anandamide biosynthesis II";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Retinoid metabolism and transport";"Arachidonic acid metabolism";"Plasmalogen degradation";"alpha-Linolenic acid metabolism";"Glycerophospholipid metabolism";"Anandamide biosynthesis I";"Acyl chain remodelling of PC";"Phosphatidylcholine acyl editing";"Ether lipid metabolism"
XP_046433907.1	1	Reactome: R-HSA-8876725	"Protein methylation"
XP_046425181.1	1	Reactome: R-HSA-4615885	"SUMOylation of DNA replication proteins"
XP_046413986.1	8	KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;Reactome: R-HSA-2028269;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1	"Relaxin signaling pathway";"Human cytomegalovirus infection";"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Signaling by Hippo";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Thermogenesis"
XP_046424483.1	6	MetaCyc: PWY-6733;Reactome: R-HSA-9640463;KEGG: 00073+1.2.1.84;MetaCyc: PWY-7656;MetaCyc: PWY-5884;MetaCyc: PWY-7782	"Sporopollenin precursors biosynthesis";"Wax biosynthesis";"Cutin, suberine and wax biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Wax esters biosynthesis I";"Plasmalogen biosynthesis"
XP_046425785.1	2	Reactome: R-HSA-3299685;MetaCyc: PWY-6854	"Detoxification of Reactive Oxygen Species";"Ethylene biosynthesis III (microbes)"
XP_046421717.1	1	Reactome: R-HSA-425410	"Metal ion SLC transporters"
XP_046429089.1	13	MetaCyc: PWY-7736;MetaCyc: PWY-5123;KEGG: 00900+2.5.1.10+2.5.1.1;MetaCyc: PWY-7659;MetaCyc: PWY-7709;MetaCyc: PWY-6383;MetaCyc: PWY-7141;MetaCyc: PWY-5122;MetaCyc: PWY-7721;MetaCyc: PWY-7410;MetaCyc: PWY-7182;MetaCyc: PWY-7102;MetaCyc: PWY-6859	"Stellatic acid biosynthesis";"Trans, trans-farnesyl diphosphate biosynthesis";"Terpenoid backbone biosynthesis";"Viridicatumtoxin biosynthesis";"(3R)-linalool biosynthesis";"Mono-trans, poly-cis decaprenyl phosphate biosynthesis";"(3S)-linalool biosynthesis";"Geranyl diphosphate biosynthesis";"Methyl phomopsenoate biosynthesis";"Ipsdienol biosynthesis";"Linalool biosynthesis I";"Bisabolene biosynthesis (engineered)";"All-trans-farnesol biosynthesis"
XP_046423391.1	1	Reactome: R-HSA-8949613	"Cristae formation"
XP_046425434.1	2	Reactome: R-HSA-375280;Reactome: R-HSA-416476	"Amine ligand-binding receptors";"G alpha (q) signalling events"
XP_046428756.1	5	Reactome: R-HSA-936964;Reactome: R-HSA-166166;Reactome: R-HSA-937072;Reactome: R-HSA-168164;Reactome: R-HSA-937041	"Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon";"MyD88-independent TLR4 cascade";"TRAF6-mediated induction of TAK1 complex within TLR4 complex";"Toll Like Receptor 3 (TLR3) Cascade";"IKK complex recruitment mediated by RIP1"
XP_046428444.1	13	MetaCyc: PWY-7184;MetaCyc: PWY-7210;Reactome: R-HSA-499943;KEGG: 00240+1.17.4.1;MetaCyc: PWY-6545;MetaCyc: PWY-7222;KEGG: 00983+1.17.4.1;MetaCyc: PWY-7220;MetaCyc: PWY-7198;MetaCyc: PWY-7227;MetaCyc: PWY-7226;KEGG: 00480+1.17.4.1;KEGG: 00230+1.17.4.1	"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Interconversion of nucleotide di- and triphosphates";"Pyrimidine metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Guanosine deoxyribonucleotides de novo biosynthesis II";"Drug metabolism - other enzymes";"Adenosine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Adenosine deoxyribonucleotides de novo biosynthesis";"Guanosine deoxyribonucleotides de novo biosynthesis I";"Glutathione metabolism";"Purine metabolism"
XP_046430993.1	2	Reactome: R-HSA-389661;Reactome: R-HSA-2408508	"Glyoxylate metabolism and glycine degradation";"Metabolism of ingested SeMet, Sec, MeSec into H2Se"
XP_046424798.1	12	Reactome: R-HSA-1632852;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;Reactome: R-HSA-380972;Reactome: R-HSA-9619483;KEGG: 05163+2.7.11.1;Reactome: R-HSA-6804756;KEGG: 04926+2.7.11.1;Reactome: R-HSA-5628897;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1	"Macroautophagy";"Thermogenesis";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Energy dependent regulation of mTOR by LKB1-AMPK";"Activation of AMPK downstream of NMDARs";"Human cytomegalovirus infection";"Regulation of TP53 Activity through Phosphorylation";"Relaxin signaling pathway";"TP53 Regulates Metabolic Genes";"mTOR signaling pathway";"PI3K-Akt signaling pathway"
XP_046421925.1	12	MetaCyc: PWY-7416;MetaCyc: PWY-8053;MetaCyc: PWY-7409;KEGG: 00564+3.1.1.4;MetaCyc: PWY-7417;KEGG: 00591+3.1.1.4;KEGG: 00565+3.1.1.4;MetaCyc: PWY-6803;MetaCyc: PWY-8051;KEGG: 00592+3.1.1.4;MetaCyc: PWY-7783;KEGG: 00590+3.1.1.4	"Phospholipid remodeling (phosphatidylcholine, yeast)";"Anandamide biosynthesis II";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Glycerophospholipid metabolism";"Phospholipid remodeling (phosphatidate, yeast)";"Linoleic acid metabolism";"Ether lipid metabolism";"Phosphatidylcholine acyl editing";"Anandamide biosynthesis I";"alpha-Linolenic acid metabolism";"Plasmalogen degradation";"Arachidonic acid metabolism"
XP_046429781.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046416713.1	2	Reactome: R-HSA-804914;Reactome: R-HSA-9029569	"Transport of fatty acids";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux"
XP_046428969.1	2	Reactome: R-HSA-1660499;Reactome: R-HSA-1632852	"Synthesis of PIPs at the plasma membrane";"Macroautophagy"
XP_046423723.1	2	KEGG: 00710+2.7.1.14;Reactome: R-HSA-71336	"Carbon fixation in photosynthetic organisms";"Pentose phosphate pathway"
XP_046425350.1	5	Reactome: R-HSA-189451;KEGG: 00260+2.3.1.37;MetaCyc: PWY-5189;MetaCyc: PWY-7536;KEGG: 00860+2.3.1.37	"Heme biosynthesis";"Glycine, serine and threonine metabolism";"Tetrapyrrole biosynthesis II (from glycine)";"2-amino-3-hydroxycyclopent-2-enone biosynthesis";"Porphyrin and chlorophyll metabolism"
XP_046417909.1	10	Reactome: R-HSA-5609977;MetaCyc: PWY-6397;KEGG: 00520+5.1.3.2;KEGG: 00052+5.1.3.2;Reactome: R-HSA-70370;MetaCyc: PWY-7328;MetaCyc: PWY-7344;MetaCyc: PWY-6527;MetaCyc: PWY-3821;MetaCyc: PWY-6317	"Defective GALE can cause Epimerase-deficiency galactosemia (EDG)";"Mycolyl-arabinogalactan-peptidoglycan complex biosynthesis";"Amino sugar and nucleotide sugar metabolism";"Galactose metabolism";"Galactose catabolism";"Superpathway of UDP-glucose-derived O-antigen building blocks biosynthesis";"UDP-alpha-D-galactose biosynthesis";"Stachyose degradation";"D-galactose detoxification";"D-galactose degradation I (Leloir pathway)"
XP_046436503.1	8	KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1;Reactome: R-HSA-2028269;KEGG: 04151+2.7.11.1	"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Thermogenesis";"Relaxin signaling pathway";"Human cytomegalovirus infection";"mTOR signaling pathway";"Signaling by Hippo";"PI3K-Akt signaling pathway"
XP_046413225.1	1	Reactome: R-HSA-70221	"Glycogen breakdown (glycogenolysis)"
XP_046423397.1	2	Reactome: R-HSA-162710;KEGG: 00563+2.4.1.198	"Synthesis of glycosylphosphatidylinositol (GPI)";"Glycosylphosphatidylinositol (GPI)-anchor biosynthesis"
XP_046419590.1	3	KEGG: 00010+5.1.3.3;KEGG: 00052+5.1.3.3;MetaCyc: PWY-6317	"Glycolysis / Gluconeogenesis";"Galactose metabolism";"D-galactose degradation I (Leloir pathway)"
XP_046418844.1	3	Reactome: R-HSA-2514859;KEGG: 00310+2.1.1.60;Reactome: R-HSA-8876725	"Inactivation, recovery and regulation of the phototransduction cascade";"Lysine degradation";"Protein methylation"
XP_046418168.1	8	Reactome: R-HSA-68867;Reactome: R-HSA-68689;Reactome: R-HSA-113507;Reactome: R-HSA-68616;Reactome: R-HSA-176187;Reactome: R-HSA-68827;Reactome: R-HSA-68949;Reactome: R-HSA-68962	"Assembly of the pre-replicative complex";"CDC6 association with the ORC:origin complex";"E2F-enabled inhibition of pre-replication complex formation";"Assembly of the ORC complex at the origin of replication";"Activation of ATR in response to replication stress";"CDT1 association with the CDC6:ORC:origin complex";"Orc1 removal from chromatin";"Activation of the pre-replicative complex"
XP_046418128.1	7	Reactome: R-HSA-2467813;Reactome: R-HSA-68877;Reactome: R-HSA-4615885;Reactome: R-HSA-141444;Reactome: R-HSA-9648025;Reactome: R-HSA-2500257;Reactome: R-HSA-5663220	"Separation of Sister Chromatids";"Mitotic Prometaphase";"SUMOylation of DNA replication proteins";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"EML4 and NUDC in mitotic spindle formation";"Resolution of Sister Chromatid Cohesion";"RHO GTPases Activate Formins"
XP_046427266.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046426582.1	2	KEGG: 00270+3.3.1.1;MetaCyc: PWY-5041	"Cysteine and methionine metabolism";"S-adenosyl-L-methionine cycle II"
XP_046425911.1	2	Reactome: R-HSA-6783310;Reactome: R-HSA-5693568	"Fanconi Anemia Pathway";"Resolution of D-loop Structures through Holliday Junction Intermediates"
XP_046427821.1	42	KEGG: 00310+4.2.1.17+1.1.1.35;MetaCyc: PWY-7778;MetaCyc: PWY-5138;KEGG: 00623+1.1.1.35;KEGG: 00720+4.2.1.17+1.1.1.35;KEGG: 00410+4.2.1.17;MetaCyc: PWY-5177;MetaCyc: PWY-7654;KEGG: 00930+4.2.1.17+1.1.1.35;MetaCyc: PWY-5789;KEGG: 00627+4.2.1.17;MetaCyc: PWY-7216;KEGG: 00071+4.2.1.17+1.1.1.35;MetaCyc: PWY-5109;MetaCyc: PWY-7094;MetaCyc: PWY-6944;KEGG: 00360+4.2.1.17;KEGG: 00650+5.1.2.3+4.2.1.17+1.1.1.35;KEGG: 00592+4.2.1.17;MetaCyc: PWY-1361;KEGG: 00380+4.2.1.17+1.1.1.35;MetaCyc: PWY-6863;MetaCyc: PWY-5136;KEGG: 00062+4.2.1.17+1.1.1.35;KEGG: 00903+4.2.1.17;KEGG: 00650+4.2.1.17+1.1.1.35;KEGG: 00362+4.2.1.17+1.1.1.35;MetaCyc: PWY-7007;MetaCyc: PWY-7606;MetaCyc: PWY-6946;MetaCyc: PWY-6945;MetaCyc: PWY-6883;MetaCyc: PWY-7726;MetaCyc: PWY-6435;KEGG: 00071+5.1.2.3+4.2.1.17+1.1.1.35;KEGG: 00640+4.2.1.17;MetaCyc: PWY-7401;MetaCyc: PWY-7656;MetaCyc: PWY-6583;KEGG: 00281+4.2.1.17+1.1.1.35;KEGG: 00280+4.2.1.17+1.1.1.35;MetaCyc: PWY-7779	"Lysine degradation";"2-methylpropene degradation";"Fatty acid beta-oxidation IV (unsaturated, even number)";"Toluene degradation";"Carbon fixation pathways in prokaryotes";"beta-Alanine metabolism";"Glutaryl-coa degradation";"(8E,10E)-dodeca-8,10-dienol biosynthesis";"Caprolactam degradation";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Aminobenzoate degradation";"(R)- and (S)-3-hydroxybutanoate biosynthesis (engineered)";"Fatty acid degradation";"Fermentation to 2-methylbutanoate";"Fatty acid salvage";"Androstenedione degradation";"Phenylalanine metabolism";"Butanoate metabolism";"alpha-Linolenic acid metabolism";"Benzoyl-coa degradation I (aerobic)";"Tryptophan metabolism";"Pyruvate fermentation to hexanol (engineered)";"Fatty acid beta-oxidation II (plant peroxisome)";"Fatty acid elongation";"Limonene and pinene degradation";"Butanoate metabolism";"Benzoate degradation";"Methyl ketone biosynthesis (engineered)";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Cholesterol degradation to androstenedione II (cholesterol dehydrogenase)";"Cholesterol degradation to androstenedione I (cholesterol oxidase)";"Pyruvate fermentation to butanol II (engineered)";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"4-hydroxybenzoate biosynthesis III (plants)";"Fatty acid degradation";"Propanoate metabolism";"Crotonate fermentation (to acetate and cyclohexane carboxylate)";"Spodoptera littoralis pheromone biosynthesis";"Pyruvate fermentation to butanol I";"Geraniol degradation";"Valine, leucine and isoleucine degradation";"Methyl tert-butyl ether degradation"
XP_046411148.1	1	Reactome: R-HSA-5676934	"Protein repair"
XP_046410705.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_046436441.1	5	Reactome: R-HSA-2871796;KEGG: 04150+2.7.11.24;Reactome: R-HSA-450321;Reactome: R-HSA-450341;Reactome: R-HSA-2559580	"FCERI mediated MAPK activation";"mTOR signaling pathway";"JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1";"Activation of the AP-1 family of transcription factors";"Oxidative Stress Induced Senescence"
XP_046433449.1	2	Reactome: R-HSA-8963888;Reactome: R-HSA-8866423	"Chylomicron assembly";"VLDL assembly"
XP_046409780.1	2	Reactome: R-HSA-6804115;Reactome: R-HSA-429947	"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Deadenylation of mRNA"
XP_046435314.1	1	Reactome: R-HSA-6799198	"Complex I biogenesis"
XP_046434948.1	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
XP_046420647.1	11	Reactome: R-HSA-5685938;Reactome: R-HSA-5358565;Reactome: R-HSA-5693554;Reactome: R-HSA-5693616;Reactome: R-HSA-6804756;Reactome: R-HSA-69473;Reactome: R-HSA-5693579;Reactome: R-HSA-5685942;Reactome: R-HSA-5693607;Reactome: R-HSA-5358606;Reactome: R-HSA-5693568	"HDR through Single Strand Annealing (SSA)";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Presynaptic phase of homologous DNA pairing and strand exchange";"Regulation of TP53 Activity through Phosphorylation";"G2/M DNA damage checkpoint";"Homologous DNA Pairing and Strand Exchange";"HDR through Homologous Recombination (HRR)";"Processing of DNA double-strand break ends";"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"Resolution of D-loop Structures through Holliday Junction Intermediates"
XP_046429745.1	7	Reactome: R-HSA-9010553;Reactome: R-HSA-5083629;Reactome: R-HSA-5173105;Reactome: R-HSA-3000171;Reactome: R-HSA-5083633;Reactome: R-HSA-3000178;Reactome: R-HSA-5083628	"Regulation of expression of SLITs and ROBOs";"Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2";"O-linked glycosylation";"Non-integrin membrane-ECM interactions";"Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1";"ECM proteoglycans";"Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3"
XP_046416904.1	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
XP_046433130.1	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
XP_046433385.1	3	Reactome: R-HSA-193648;Reactome: R-HSA-416482;Reactome: R-HSA-194840	"NRAGE signals death through JNK";"G alpha (12/13) signalling events";"Rho GTPase cycle"
XP_046429875.1	7	Reactome: R-HSA-69205;Reactome: R-HSA-1362277;Reactome: R-HSA-69202;Reactome: R-HSA-1538133;Reactome: R-HSA-69656;Reactome: R-HSA-156711;Reactome: R-HSA-1362300	"G1/S-Specific Transcription";"Transcription of E2F targets under negative control by DREAM complex";"Cyclin E associated events during G1/S transition";"G0 and Early G1";"Cyclin A:Cdk2-associated events at S phase entry";"Polo-like kinase mediated events";"Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1"
XP_046432832.1	3	Reactome: R-HSA-5576893;Reactome: R-HSA-1296072;Reactome: R-HSA-5576890	"Phase 2 - plateau phase";"Voltage gated Potassium channels";"Phase 3 - rapid repolarisation"
XP_046434428.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046435341.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_046434923.1	2	KEGG: 00230+4.6.1.1;Reactome: R-HSA-196819	"Purine metabolism";"Vitamin B1 (thiamin) metabolism"
XP_046425266.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_046424492.1	10	Reactome: R-HSA-167161;Reactome: R-HSA-6804756;Reactome: R-HSA-3214847;Reactome: R-HSA-674695;Reactome: R-HSA-73776;Reactome: R-HSA-73779;Reactome: R-HSA-75953;Reactome: R-HSA-76042;Reactome: R-HSA-167172;Reactome: R-HSA-167162	"HIV Transcription Initiation";"Regulation of TP53 Activity through Phosphorylation";"HATs acetylate histones";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Transcription of the HIV genome";"RNA Polymerase II HIV Promoter Escape"
XP_046423288.1	2	Reactome: R-HSA-1268020;Reactome: R-HSA-8949613	"Mitochondrial protein import";"Cristae formation"
XP_046436104.1	2	Reactome: R-HSA-379726;KEGG: 00970+6.1.1.2	"Mitochondrial tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis"
XP_046417185.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046417547.1	1	Reactome: R-HSA-186797	"Signaling by PDGF"
XP_046410596.1	1	Reactome: R-HSA-6799198	"Complex I biogenesis"
XP_046419604.1	7	Reactome: R-HSA-1483191;MetaCyc: PWY-7886;MetaCyc: PWY-3385;Reactome: R-HSA-1483213;MetaCyc: PWY-7782;MetaCyc: PWY-7818;KEGG: 00564+2.7.1.32+2.7.1.82	"Synthesis of PC";"Cell-surface glycoconjugate-linked phosphocholine biosynthesis";"Choline biosynthesis I";"Synthesis of PE";"Plasmalogen biosynthesis";"Type IV lipoteichoic acid biosynthesis (S. pneumoniae)";"Glycerophospholipid metabolism"
XP_046410735.1	4	Reactome: R-HSA-112308;Reactome: R-HSA-5576892;Reactome: R-HSA-419037;Reactome: R-HSA-5576893	"Presynaptic depolarization and calcium channel opening";"Phase 0 - rapid depolarisation";"NCAM1 interactions";"Phase 2 - plateau phase"
XP_046427512.1	3	KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway"
XP_046421018.1	6	MetaCyc: PWY-7656;KEGG: 00073+1.2.1.84;Reactome: R-HSA-9640463;MetaCyc: PWY-6733;MetaCyc: PWY-7782;MetaCyc: PWY-5884	"Spodoptera littoralis pheromone biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax biosynthesis";"Sporopollenin precursors biosynthesis";"Plasmalogen biosynthesis";"Wax esters biosynthesis I"
XP_046432079.1	7	KEGG: 04926+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1	"Relaxin signaling pathway";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Human cytomegalovirus infection";"Thermogenesis";"PI3K-Akt signaling pathway";"mTOR signaling pathway"
XP_046419720.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046428798.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_046436403.1	1	Reactome: R-HSA-6811436	"COPI-independent Golgi-to-ER retrograde traffic"
XP_046421916.1	6	Reactome: R-HSA-9648025;Reactome: R-HSA-141444;Reactome: R-HSA-68877;Reactome: R-HSA-2467813;Reactome: R-HSA-5663220;Reactome: R-HSA-2500257	"EML4 and NUDC in mitotic spindle formation";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Mitotic Prometaphase";"Separation of Sister Chromatids";"RHO GTPases Activate Formins";"Resolution of Sister Chromatid Cohesion"
XP_046435878.1	3	Reactome: R-HSA-445095;Reactome: R-HSA-6807878;Reactome: R-HSA-8963901	"Interaction between L1 and Ankyrins";"COPI-mediated anterograde transport";"Chylomicron remodeling"
XP_046416862.1	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
XP_046436297.1	7	Reactome: R-HSA-380320;Reactome: R-HSA-380270;Reactome: R-HSA-2565942;Reactome: R-HSA-8854518;Reactome: R-HSA-380259;Reactome: R-HSA-5620912;Reactome: R-HSA-380284	"Recruitment of NuMA to mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes";"Regulation of PLK1 Activity at G2/M Transition";"AURKA Activation by TPX2";"Loss of Nlp from mitotic centrosomes";"Anchoring of the basal body to the plasma membrane";"Loss of proteins required for interphase microtubule organization from the centrosome"
XP_046409322.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_046427213.1	5	Reactome: R-HSA-6804758;Reactome: R-HSA-73762;Reactome: R-HSA-427389;Reactome: R-HSA-8943724;Reactome: R-HSA-3214815	"Regulation of TP53 Activity through Acetylation";"RNA Polymerase I Transcription Initiation";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"Regulation of PTEN gene transcription";"HDACs deacetylate histones"
XP_046424403.1	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
XP_046430480.1	4	Reactome: R-HSA-4641265;Reactome: R-HSA-2122947;Reactome: R-HSA-201722;Reactome: R-HSA-3769402	"Repression of WNT target genes";"NOTCH1 Intracellular Domain Regulates Transcription";"Formation of the beta-catenin:TCF transactivating complex";"Deactivation of the beta-catenin transactivating complex"
XP_046419621.1	11	Reactome: R-HSA-1989781;Reactome: R-HSA-400253;Reactome: R-HSA-1368082;Reactome: R-HSA-9018519;Reactome: R-HSA-400206;Reactome: R-HSA-383280;Reactome: R-HSA-212436;Reactome: R-HSA-381340;Reactome: R-HSA-2426168;Reactome: R-HSA-2151201;Reactome: R-HSA-1368108	"PPARA activates gene expression";"Circadian Clock";"RORA activates gene expression";"Estrogen-dependent gene expression";"Regulation of lipid metabolism by PPARalpha";"Nuclear Receptor transcription pathway";"Generic Transcription Pathway";"Transcriptional regulation of white adipocyte differentiation";"Activation of gene expression by SREBF (SREBP)";"Transcriptional activation of mitochondrial biogenesis";"BMAL1:CLOCK,NPAS2 activates circadian gene expression"
XP_046434423.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_046418921.1	3	Reactome: R-HSA-5628897;KEGG: 00480+1.11.1.15;Reactome: R-HSA-3299685	"TP53 Regulates Metabolic Genes";"Glutathione metabolism";"Detoxification of Reactive Oxygen Species"
XP_046423429.1	11	Reactome: R-HSA-877312;Reactome: R-HSA-512988;Reactome: R-HSA-210990;Reactome: R-HSA-388841;Reactome: R-HSA-9008059;Reactome: R-HSA-909733;Reactome: R-HSA-391160;Reactome: R-HSA-912694;Reactome: R-HSA-389948;Reactome: R-HSA-114604;Reactome: R-HSA-432142	"Regulation of IFNG signaling";"Interleukin-3, Interleukin-5 and GM-CSF signaling";"PECAM1 interactions";"Costimulation by the CD28 family";"Interleukin-37 signaling";"Interferon alpha/beta signaling";"Signal regulatory protein family interactions";"Regulation of IFNA signaling";"PD-1 signaling";"GPVI-mediated activation cascade";"Platelet sensitization by LDL"
XP_046414788.1	1	Reactome: R-HSA-430039	"mRNA decay by 5' to 3' exoribonuclease"
XP_046416831.1	1	Reactome: R-HSA-5576886	"Phase 4 - resting membrane potential"
XP_046424401.1	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
XP_046427529.1	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
XP_046414761.1	8	MetaCyc: PWY-5481;KEGG: 00640+1.1.1.27;Reactome: R-HSA-70268;MetaCyc: PWY-8086;KEGG: 00620+1.1.1.27;KEGG: 00270+1.1.1.27;MetaCyc: PWY-6901;KEGG: 00010+1.1.1.27	"Pyruvate fermentation to (S)-lactate";"Propanoate metabolism";"Pyruvate metabolism";"(S)-lactate fermentation to propanoate, acetate and hydrogen";"Pyruvate metabolism";"Cysteine and methionine metabolism";"Superpathway of glucose and xylose degradation";"Glycolysis / Gluconeogenesis"
XP_046412327.1	2	Reactome: R-HSA-983168;Reactome: R-HSA-8951664	"Antigen processing: Ubiquitination & Proteasome degradation";"Neddylation"
XP_046420094.1	7	Reactome: R-HSA-70268;KEGG: 00010+2.3.1.12;KEGG: 00020+2.3.1.12;KEGG: 00620+2.3.1.12;Reactome: R-HSA-204174;Reactome: R-HSA-389661;Reactome: R-HSA-5362517	"Pyruvate metabolism";"Glycolysis / Gluconeogenesis";"Citrate cycle (TCA cycle)";"Pyruvate metabolism";"Regulation of pyruvate dehydrogenase (PDH) complex";"Glyoxylate metabolism and glycine degradation";"Signaling by Retinoic Acid"
XP_046424194.1	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
XP_046427178.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046433802.1	5	Reactome: R-HSA-901032;MetaCyc: PWY-7511;Reactome: R-HSA-5362768;Reactome: R-HSA-5358346;Reactome: R-HSA-381038	"ER Quality Control Compartment (ERQC)";"Protein ubiquitination";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Hedgehog ligand biogenesis";"XBP1(S) activates chaperone genes"
XP_046429679.1	15	Reactome: R-HSA-9029569;Reactome: R-HSA-2559580;Reactome: R-HSA-9022692;Reactome: R-HSA-8853884;Reactome: R-HSA-5687128;Reactome: R-HSA-8943723;Reactome: R-HSA-1912408;Reactome: R-HSA-4086398;Reactome: R-HSA-8986944;Reactome: R-HSA-2559585;Reactome: R-HSA-8948700;Reactome: R-HSA-5628897;Reactome: R-HSA-8934593;Reactome: R-HSA-9018519;Reactome: R-HSA-8936459	"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Oxidative Stress Induced Senescence";"Regulation of MECP2 expression and activity";"Transcriptional Regulation by VENTX";"MAPK6/MAPK4 signaling";"Regulation of PTEN mRNA translation";"Pre-NOTCH Transcription and Translation";"Ca2+ pathway";"Transcriptional Regulation by MECP2";"Oncogene Induced Senescence";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"TP53 Regulates Metabolic Genes";"Regulation of RUNX1 Expression and Activity";"Estrogen-dependent gene expression";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"
XP_046422801.1	2	Reactome: R-HSA-3214847;Reactome: R-HSA-171319	"HATs acetylate histones";"Telomere Extension By Telomerase"
XP_046409938.1	2	Reactome: R-HSA-71403;Reactome: R-HSA-611105	"Citric acid cycle (TCA cycle)";"Respiratory electron transport"
XP_046430392.1	2	Reactome: R-HSA-5610787;Reactome: R-HSA-5620924	"Hedgehog 'off' state";"Intraflagellar transport"
XP_046411759.1	4	Reactome: R-HSA-983712;Reactome: R-HSA-1222556;Reactome: R-HSA-77387;Reactome: R-HSA-917977	"Ion channel transport";"ROS and RNS production in phagocytes";"Insulin receptor recycling";"Transferrin endocytosis and recycling"
XP_046420805.1	5	Reactome: R-HSA-9633012;Reactome: R-HSA-8963693;KEGG: 00250+6.3.5.4;Reactome: R-HSA-380994;Reactome: R-HSA-9648895	"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Aspartate and asparagine metabolism";"Alanine, aspartate and glutamate metabolism";"ATF4 activates genes in response to endoplasmic reticulum stress";"Response of EIF2AK1 (HRI) to heme deficiency"
XP_046414511.1	2	Reactome: R-HSA-1483152;Reactome: R-HSA-1483115	"Hydrolysis of LPE";"Hydrolysis of LPC"
XP_046420157.1	3	MetaCyc: PWY-7560;Reactome: R-HSA-5666185;KEGG: 00900+2.7.7.60	"Methylerythritol phosphate pathway II";"RHO GTPases Activate Rhotekin and Rhophilins";"Terpenoid backbone biosynthesis"
XP_046418459.1	2	Reactome: R-HSA-5576893;Reactome: R-HSA-5576892	"Phase 2 - plateau phase";"Phase 0 - rapid depolarisation"
XP_046433506.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_046410811.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046428632.1	7	MetaCyc: PWY-6368;Reactome: R-HSA-1855204;KEGG: 00562+3.1.3.36;KEGG: 04070+3.1.3.36;Reactome: R-HSA-1660499;Reactome: R-HSA-1855183;Reactome: R-HSA-8856828	"3-phosphoinositide degradation";"Synthesis of IP3 and IP4 in the cytosol";"Inositol phosphate metabolism";"Phosphatidylinositol signaling system";"Synthesis of PIPs at the plasma membrane";"Synthesis of IP2, IP, and Ins in the cytosol";"Clathrin-mediated endocytosis"
XP_046433248.1	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046432294.1	4	KEGG: 00230+4.1.1.97;MetaCyc: PWY-7394;MetaCyc: PWY-7849;MetaCyc: PWY-5691	"Purine metabolism";"Urate conversion to allantoin II";"Urate conversion to allantoin III";"Urate conversion to allantoin I"
XP_046417527.1	5	Reactome: R-HSA-9615710;Reactome: R-HSA-174490;Reactome: R-HSA-917729;Reactome: R-HSA-162588;Reactome: R-HSA-9610379	"Late endosomal microautophagy";"Membrane binding and targetting of GAG proteins";"Endosomal Sorting Complex Required For Transport (ESCRT)";"Budding and maturation of HIV virion";"HCMV Late Events"
XP_046430928.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_046423154.1	17	KEGG: 00240+2.7.4.6;MetaCyc: PWY-7198;MetaCyc: PWY-7184;MetaCyc: PWY-7210;MetaCyc: PWY-7187;MetaCyc: PWY-6545;KEGG: 00230+2.7.4.6;MetaCyc: PWY-7221;MetaCyc: PWY-7222;MetaCyc: PWY-7205;MetaCyc: PWY-7220;MetaCyc: PWY-7176;KEGG: 00983+2.7.4.6;MetaCyc: PWY-7227;MetaCyc: PWY-7224;MetaCyc: PWY-7226;MetaCyc: PWY-7197	"Pyrimidine metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Pyrimidine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis";"Guanosine deoxyribonucleotides de novo biosynthesis II";"CMP phosphorylation";"Adenosine deoxyribonucleotides de novo biosynthesis II";"UTP and CTP de novo biosynthesis";"Drug metabolism - other enzymes";"Adenosine deoxyribonucleotides de novo biosynthesis";"Purine deoxyribonucleosides salvage";"Guanosine deoxyribonucleotides de novo biosynthesis I";"Pyrimidine deoxyribonucleotide phosphorylation"
XP_046425050.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_046427289.1	2	KEGG: 00030+2.7.1.15;Reactome: R-HSA-71336	"Pentose phosphate pathway";"Pentose phosphate pathway"
XP_046434766.1	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
XP_046423920.1	11	Reactome: R-HSA-674695;Reactome: R-HSA-167200;Reactome: R-HSA-6796648;Reactome: R-HSA-167287;Reactome: R-HSA-167290;Reactome: R-HSA-167152;Reactome: R-HSA-75955;Reactome: R-HSA-167246;Reactome: R-HSA-112382;Reactome: R-HSA-167243;Reactome: R-HSA-167238	"RNA Polymerase II Pre-transcription Events";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"TP53 Regulates Transcription of DNA Repair Genes";"HIV elongation arrest and recovery";"Pausing and recovery of HIV elongation";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Polymerase II Transcription Elongation";"Tat-mediated elongation of the HIV-1 transcript";"Formation of RNA Pol II elongation complex";"Tat-mediated HIV elongation arrest and recovery";"Pausing and recovery of Tat-mediated HIV elongation"
XP_046433178.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046416787.1	5	MetaCyc: PWY-6558;Reactome: R-HSA-3656253;Reactome: R-HSA-3656237;Reactome: R-HSA-2022928;KEGG: 00534+2.4.1.224+2.4.1.225	"Heparan sulfate biosynthesis (late stages)";"Defective EXT1 causes exostoses 1, TRPS2 and CHDS";"Defective EXT2 causes exostoses 2";"HS-GAG biosynthesis";"Glycosaminoglycan biosynthesis - heparan sulfate / heparin"
XP_046432397.1	17	Reactome: R-HSA-5685942;Reactome: R-HSA-5693607;Reactome: R-HSA-912446;Reactome: R-HSA-5693548;Reactome: R-HSA-2559586;Reactome: R-HSA-5693579;Reactome: R-HSA-5693568;Reactome: R-HSA-5693554;Reactome: R-HSA-5685939;Reactome: R-HSA-5685938;Reactome: R-HSA-5693565;Reactome: R-HSA-3270619;Reactome: R-HSA-5693616;Reactome: R-HSA-1834949;Reactome: R-HSA-5693571;Reactome: R-HSA-6804756;Reactome: R-HSA-69473	"HDR through Homologous Recombination (HRR)";"Processing of DNA double-strand break ends";"Meiotic recombination";"Sensing of DNA Double Strand Breaks";"DNA Damage/Telomere Stress Induced Senescence";"Homologous DNA Pairing and Strand Exchange";"Resolution of D-loop Structures through Holliday Junction Intermediates";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"HDR through MMEJ (alt-NHEJ)";"HDR through Single Strand Annealing (SSA)";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"IRF3-mediated induction of type I IFN";"Presynaptic phase of homologous DNA pairing and strand exchange";"Cytosolic sensors of pathogen-associated DNA";"Nonhomologous End-Joining (NHEJ)";"Regulation of TP53 Activity through Phosphorylation";"G2/M DNA damage checkpoint"
XP_046410046.1	5	KEGG: 00740+2.7.1.26;MetaCyc: PWY-5523;Reactome: R-HSA-196843;MetaCyc: PWY-6168;MetaCyc: PWY-7863	"Riboflavin metabolism";"5,6-dimethylbenzimidazole biosynthesis I (aerobic)";"Vitamin B2 (riboflavin) metabolism";"Flavin biosynthesis III (fungi)";"Roseoflavin biosynthesis"
XP_046418190.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046433384.1	3	Reactome: R-HSA-193648;Reactome: R-HSA-194840;Reactome: R-HSA-416482	"NRAGE signals death through JNK";"Rho GTPase cycle";"G alpha (12/13) signalling events"
XP_046416519.1	1	Reactome: R-HSA-5649702	"APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway"
XP_046425748.1	2	Reactome: R-HSA-2682334;Reactome: R-HSA-3928665	"EPH-Ephrin signaling";"EPH-ephrin mediated repulsion of cells"
XP_046420398.1	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
XP_046418791.1	2	Reactome: R-HSA-983168;Reactome: R-HSA-6798695	"Antigen processing: Ubiquitination & Proteasome degradation";"Neutrophil degranulation"
XP_046435309.1	2	Reactome: R-HSA-72165;Reactome: R-HSA-72163	"mRNA Splicing - Minor Pathway";"mRNA Splicing - Major Pathway"
XP_046431030.1	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
XP_046417359.1	1	Reactome: R-HSA-3214858	"RMTs methylate histone arginines"
XP_046417107.1	3	Reactome: R-HSA-2029482;Reactome: R-HSA-5663213;Reactome: R-HSA-4420097	"Regulation of actin dynamics for phagocytic cup formation";"RHO GTPases Activate WASPs and WAVEs";"VEGFA-VEGFR2 Pathway"
XP_046429627.1	6	Reactome: R-HSA-72695;Reactome: R-HSA-72702;Reactome: R-HSA-72706;Reactome: R-HSA-72649;Reactome: R-HSA-72689;Reactome: R-HSA-156827	"Formation of the ternary complex, and subsequently, the 43S complex";"Ribosomal scanning and start codon recognition";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Translation initiation complex formation";"Formation of a pool of free 40S subunits";"L13a-mediated translational silencing of Ceruloplasmin expression"
XP_046427780.1	1	Reactome: R-HSA-9633012	"Response of EIF2AK4 (GCN2) to amino acid deficiency"
XP_046428692.1	22	MetaCyc: PWY-5353;MetaCyc: PWY-6958;MetaCyc: PWY-7601;MetaCyc: PWY-7053;MetaCyc: PWY-7602;MetaCyc: PWY-7036;MetaCyc: PWY-6598;KEGG: 00062+4.2.1.134;MetaCyc: PWY-7726;Reactome: R-HSA-75876;MetaCyc: PWY-7724;MetaCyc: PWY-7728;MetaCyc: PWY-7606;MetaCyc: PWY-7592;MetaCyc: PWY-7725;MetaCyc: PWY-7619;MetaCyc: PWY-5080;MetaCyc: PWY-8041;MetaCyc: PWY-7035;MetaCyc: PWY-7727;MetaCyc: PWY-6433;MetaCyc: PWY-7049	"Arachidonate biosynthesis I (6-desaturase, lower eukaryotes)";"Icosapentaenoate biosynthesis I (lower eukaryotes)";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Docosahexaenoate biosynthesis I (lower eukaryotes)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis II";"Sciadonate biosynthesis";"Fatty acid elongation";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"Synthesis of very long-chain fatty acyl-CoAs";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Arachidonate biosynthesis III (6-desaturase, mammals)";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Juniperonate biosynthesis";"Very long chain fatty acid biosynthesis I";"Ultra-long-chain fatty acid biosynthesis";"(9Z)-tricosene biosynthesis";"Docosahexaenoate biosynthesis IV (4-desaturase, mammals)";"Hydroxylated fatty acid biosynthesis (plants)";"Icosapentaenoate biosynthesis II (6-desaturase, mammals)"
XP_046432801.1	1	KEGG: 00480+3.4.11.1	"Glutathione metabolism"
XP_046420071.1	16	Reactome: R-HSA-72695;Reactome: R-HSA-1799339;Reactome: R-HSA-72689;Reactome: R-HSA-192823;Reactome: R-HSA-156902;Reactome: R-HSA-72649;Reactome: R-HSA-72764;Reactome: R-HSA-975957;Reactome: R-HSA-72706;Reactome: R-HSA-2408557;Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-72702;Reactome: R-HSA-975956;Reactome: R-HSA-6791226	"Formation of the ternary complex, and subsequently, the 43S complex";"SRP-dependent cotranslational protein targeting to membrane";"Formation of a pool of free 40S subunits";"Viral mRNA Translation";"Peptide chain elongation";"Translation initiation complex formation";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Selenocysteine synthesis";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Ribosomal scanning and start codon recognition";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046422502.1	1	Reactome: R-HSA-69231	"Cyclin D associated events in G1"
XP_046416275.1	1	Reactome: R-HSA-5576886	"Phase 4 - resting membrane potential"
XP_046427464.1	1	Reactome: R-HSA-1660661	"Sphingolipid de novo biosynthesis"
XP_046421662.1	2	Reactome: R-HSA-3299685;MetaCyc: PWY-6854	"Detoxification of Reactive Oxygen Species";"Ethylene biosynthesis III (microbes)"
XP_046429737.1	7	Reactome: R-HSA-3000178;Reactome: R-HSA-5083628;Reactome: R-HSA-5083633;Reactome: R-HSA-3000171;Reactome: R-HSA-9010553;Reactome: R-HSA-5083629;Reactome: R-HSA-5173105	"ECM proteoglycans";"Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3";"Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1";"Non-integrin membrane-ECM interactions";"Regulation of expression of SLITs and ROBOs";"Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2";"O-linked glycosylation"
XP_046411388.1	5	KEGG: 00760+2.7.1.23;MetaCyc: PWY-7269;Reactome: R-HSA-196807;MetaCyc: PWY-7268;MetaCyc: PWY-5083	"Nicotinate and nicotinamide metabolism";"NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)";"Nicotinate metabolism";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"NAD/NADH phosphorylation and dephosphorylation"
XP_046428770.1	7	KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1	"Human cytomegalovirus infection";"Thermogenesis";"Relaxin signaling pathway";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"PI3K-Akt signaling pathway";"mTOR signaling pathway"
XP_046434607.1	8	Reactome: R-HSA-432040;Reactome: R-HSA-983231;Reactome: R-HSA-442720;Reactome: R-HSA-180024;Reactome: R-HSA-381676;Reactome: R-HSA-5610787;Reactome: R-HSA-163615;Reactome: R-HSA-164378	"Vasopressin regulates renal water homeostasis via Aquaporins";"Factors involved in megakaryocyte development and platelet production";"CREB1 phosphorylation through the activation of Adenylate Cyclase";"DARPP-32 events";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"Hedgehog 'off' state";"PKA activation";"PKA activation in glucagon signalling"
XP_046417580.1	12	Reactome: R-HSA-75955;Reactome: R-HSA-167246;Reactome: R-HSA-167243;Reactome: R-HSA-167238;Reactome: R-HSA-112382;Reactome: R-HSA-6796648;Reactome: R-HSA-167200;Reactome: R-HSA-167287;Reactome: R-HSA-674695;Reactome: R-HSA-167152;Reactome: R-HSA-6804756;Reactome: R-HSA-167290	"RNA Polymerase II Transcription Elongation";"Tat-mediated elongation of the HIV-1 transcript";"Tat-mediated HIV elongation arrest and recovery";"Pausing and recovery of Tat-mediated HIV elongation";"Formation of RNA Pol II elongation complex";"TP53 Regulates Transcription of DNA Repair Genes";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"HIV elongation arrest and recovery";"RNA Polymerase II Pre-transcription Events";"Formation of HIV elongation complex in the absence of HIV Tat";"Regulation of TP53 Activity through Phosphorylation";"Pausing and recovery of HIV elongation"
XP_046417973.1	2	Reactome: R-HSA-1660662;Reactome: R-HSA-390471	"Glycosphingolipid metabolism";"Association of TriC/CCT with target proteins during biosynthesis"
XP_046419408.1	2	KEGG: 00900+2.5.1.58;Reactome: R-HSA-2514859	"Terpenoid backbone biosynthesis";"Inactivation, recovery and regulation of the phototransduction cascade"
XP_046416462.1	7	Reactome: R-HSA-2894862;Reactome: R-HSA-2122948;Reactome: R-HSA-177929;Reactome: R-HSA-2644606;Reactome: R-HSA-2660826;Reactome: R-HSA-2691232;Reactome: R-HSA-1442490	"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Activated NOTCH1 Transmits Signal to the Nucleus";"Signaling by EGFR";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant";"Constitutive Signaling by NOTCH1 HD Domain Mutants";"Collagen degradation"
XP_046424912.1	7	Reactome: R-HSA-749476;Reactome: R-HSA-1834949;Reactome: R-HSA-76071;Reactome: R-HSA-73780;Reactome: R-HSA-73980;Reactome: R-HSA-76066;Reactome: R-HSA-76061	"RNA Polymerase III Abortive And Retractive Initiation";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Chain Elongation";"RNA Polymerase III Transcription Termination";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Transcription Initiation From Type 1 Promoter"
XP_046420219.1	15	Reactome: R-HSA-5467333;Reactome: R-HSA-5358751;Reactome: R-HSA-195253;Reactome: R-HSA-5358752;Reactome: R-HSA-3769402;Reactome: R-HSA-5358747;Reactome: R-HSA-4641262;Reactome: R-HSA-111465;Reactome: R-HSA-5339716;Reactome: R-HSA-5467340;Reactome: R-HSA-196299;Reactome: R-HSA-5689896;Reactome: R-HSA-5358749;Reactome: R-HSA-5467348;Reactome: R-HSA-5467337	"APC truncation mutants are not K63 polyubiquitinated";"S45 mutants of beta-catenin aren't phosphorylated";"Degradation of beta-catenin by the destruction complex";"T41 mutants of beta-catenin aren't phosphorylated";"Deactivation of the beta-catenin transactivating complex";"S33 mutants of beta-catenin aren't phosphorylated";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"Apoptotic cleavage of cellular proteins";"Misspliced GSK3beta mutants stabilize beta-catenin";"AXIN missense mutants destabilize the destruction complex";"Beta-catenin phosphorylation cascade";"Ovarian tumor domain proteases";"S37 mutants of beta-catenin aren't phosphorylated";"Truncations of AMER1 destabilize the destruction complex";"APC truncation mutants have impaired AXIN binding"
XP_046435087.1	2	Reactome: R-HSA-2672351;Reactome: R-HSA-5578775	"Stimuli-sensing channels";"Ion homeostasis"
XP_046414582.1	1	Reactome: R-HSA-1660661	"Sphingolipid de novo biosynthesis"
XP_046409575.1	3	Reactome: R-HSA-5696395;Reactome: R-HSA-5689877;Reactome: R-HSA-5696394	"Formation of Incision Complex in GG-NER";"Josephin domain DUBs";"DNA Damage Recognition in GG-NER"
XP_046423000.1	1	Reactome: R-HSA-429947	"Deadenylation of mRNA"
XP_046417658.1	5	MetaCyc: PWY-7279;MetaCyc: PWY-7082;MetaCyc: PWY-6692;KEGG: 00190+7.1.1.8;MetaCyc: PWY-3781	"Aerobic respiration II (cytochrome c) (yeast)";"Ammonia oxidation IV (autotrophic ammonia oxidizers)";"Fe(II) oxidation";"Oxidative phosphorylation";"Aerobic respiration I (cytochrome c)"
XP_046433816.1	13	Reactome: R-HSA-6802955;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;Reactome: R-HSA-5674135;KEGG: 04926+2.7.11.1;Reactome: R-HSA-9649948;KEGG: 05163+2.7.11.1;Reactome: R-HSA-6802948;Reactome: R-HSA-6802952;Reactome: R-HSA-6802946;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04714+2.7.11.1	"Paradoxical activation of RAF signaling by kinase inactive BRAF";"mTOR signaling pathway";"PI3K-Akt signaling pathway";"MAP2K and MAPK activation";"Relaxin signaling pathway";"Signaling downstream of RAS mutants";"Human cytomegalovirus infection";"Signaling by high-kinase activity BRAF mutants";"Signaling by BRAF and RAF fusions";"Signaling by moderate kinase activity BRAF mutants";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Thermogenesis"
XP_046415401.1	1	Reactome: R-HSA-114608	"Platelet degranulation"
XP_046417101.1	6	MetaCyc: PWY-7656;KEGG: 00073+1.2.1.84;MetaCyc: PWY-6733;Reactome: R-HSA-9640463;MetaCyc: PWY-5884;MetaCyc: PWY-7782	"Spodoptera littoralis pheromone biosynthesis";"Cutin, suberine and wax biosynthesis";"Sporopollenin precursors biosynthesis";"Wax biosynthesis";"Wax esters biosynthesis I";"Plasmalogen biosynthesis"
XP_046419931.1	8	Reactome: R-HSA-5173105;Reactome: R-HSA-5083629;MetaCyc: PWY-7922;KEGG: 00514+2.4.1.109;MetaCyc: PWY-7921;Reactome: R-HSA-5083633;MetaCyc: PWY-7979;KEGG: 00515+2.4.1.109	"O-linked glycosylation";"Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2";"Protein O-mannosylation II (mammals, core M1 and core M2)";"Other types of O-glycan biosynthesis";"Protein O-mannosylation I (yeast)";"Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1";"Protein O-mannosylation III (mammals, core M3)";"Mannose type O-glycan biosynthesis"
XP_046426474.1	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
XP_046411290.1	2	Reactome: R-HSA-167827;Reactome: R-HSA-167826	"The proton buffering model";"The fatty acid cycling model"
XP_046421286.1	6	Reactome: R-HSA-141444;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813;Reactome: R-HSA-68877;Reactome: R-HSA-2500257;Reactome: R-HSA-5663220	"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids";"Mitotic Prometaphase";"Resolution of Sister Chromatid Cohesion";"RHO GTPases Activate Formins"
XP_046433929.1	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840	"Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation"
XP_046413249.1	1	Reactome: R-HSA-6811440	"Retrograde transport at the Trans-Golgi-Network"
XP_046420688.1	2	KEGG: 00970+6.1.1.20;Reactome: R-HSA-379716	"Aminoacyl-tRNA biosynthesis";"Cytosolic tRNA aminoacylation"
XP_046423343.1	2	KEGG: 00230+3.1.4.53;Reactome: R-HSA-180024	"Purine metabolism";"DARPP-32 events"
XP_046419681.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_046411426.1	9	Reactome: R-HSA-167172;Reactome: R-HSA-167162;Reactome: R-HSA-75953;Reactome: R-HSA-76042;Reactome: R-HSA-167161;Reactome: R-HSA-6804756;Reactome: R-HSA-73779;Reactome: R-HSA-674695;Reactome: R-HSA-73776	"Transcription of the HIV genome";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"HIV Transcription Initiation";"Regulation of TP53 Activity through Phosphorylation";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Promoter Escape"
XP_046434842.1	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
XP_046413400.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_046410327.1	8	Reactome: R-HSA-6804115;Reactome: R-HSA-380284;Reactome: R-HSA-380259;Reactome: R-HSA-380320;Reactome: R-HSA-2565942;Reactome: R-HSA-5620912;Reactome: R-HSA-8854518;Reactome: R-HSA-380270	"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Loss of proteins required for interphase microtubule organization from the centrosome";"Loss of Nlp from mitotic centrosomes";"Recruitment of NuMA to mitotic centrosomes";"Regulation of PLK1 Activity at G2/M Transition";"Anchoring of the basal body to the plasma membrane";"AURKA Activation by TPX2";"Recruitment of mitotic centrosome proteins and complexes"
XP_046427800.1	1	Reactome: R-HSA-196819	"Vitamin B1 (thiamin) metabolism"
XP_046426441.1	3	Reactome: R-HSA-6782135;Reactome: R-HSA-5696400;Reactome: R-HSA-5696395	"Dual incision in TC-NER";"Dual Incision in GG-NER";"Formation of Incision Complex in GG-NER"
XP_046422751.1	1	Reactome: R-HSA-156584	"Cytosolic sulfonation of small molecules"
XP_046417812.1	1	Reactome: R-HSA-2022377	"Metabolism of Angiotensinogen to Angiotensins"
XP_046420362.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_046431078.1	4	Reactome: R-HSA-201722;Reactome: R-HSA-2122947;Reactome: R-HSA-4641265;Reactome: R-HSA-3769402	"Formation of the beta-catenin:TCF transactivating complex";"NOTCH1 Intracellular Domain Regulates Transcription";"Repression of WNT target genes";"Deactivation of the beta-catenin transactivating complex"
XP_046418714.1	3	Reactome: R-HSA-4420097;KEGG: 04660+2.7.10.2;Reactome: R-HSA-391160	"VEGFA-VEGFR2 Pathway";"T cell receptor signaling pathway";"Signal regulatory protein family interactions"
XP_046419767.1	1	Reactome: R-HSA-420499	"Class C/3 (Metabotropic glutamate/pheromone receptors)"
XP_046411354.1	5	MetaCyc: PWY-7269;KEGG: 00760+2.7.1.23;Reactome: R-HSA-196807;MetaCyc: PWY-7268;MetaCyc: PWY-5083	"NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)";"Nicotinate and nicotinamide metabolism";"Nicotinate metabolism";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"NAD/NADH phosphorylation and dephosphorylation"
XP_046434017.1	1	Reactome: R-HSA-1296061	"HCN channels"
XP_046422753.1	1	Reactome: R-HSA-156584	"Cytosolic sulfonation of small molecules"
XP_046411014.1	5	Reactome: R-HSA-8854214;Reactome: R-HSA-165181;Reactome: R-HSA-5628897;Reactome: R-HSA-380972;Reactome: R-HSA-1632852	"TBC/RABGAPs";"Inhibition of TSC complex formation by PKB";"TP53 Regulates Metabolic Genes";"Energy dependent regulation of mTOR by LKB1-AMPK";"Macroautophagy"
XP_046432898.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_046432565.1	1	Reactome: R-HSA-611105	"Respiratory electron transport"
XP_046416072.1	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
XP_046412337.1	4	Reactome: R-HSA-1660662;KEGG: 00600+3.5.1.23;MetaCyc: PWY-7119;MetaCyc: PWY-6483	"Glycosphingolipid metabolism";"Sphingolipid metabolism";"Ceramide and sphingolipid recycling and degradation (yeast)";"Ceramide degradation (generic)"
XP_046425309.1	3	Reactome: R-HSA-193648;Reactome: R-HSA-194840;Reactome: R-HSA-416482	"NRAGE signals death through JNK";"Rho GTPase cycle";"G alpha (12/13) signalling events"
XP_046409666.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_046426195.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_046415111.1	22	KEGG: 00500+5.3.1.9;MetaCyc: PWY-6142;Reactome: R-HSA-5628897;MetaCyc: PWY-6981;MetaCyc: PWY-622;KEGG: 00030+5.3.1.9;MetaCyc: PWY-6992;Reactome: R-HSA-70171;MetaCyc: PWY-5384;Reactome: R-HSA-6798695;MetaCyc: PWY-3801;MetaCyc: PWY-7385;MetaCyc: PWY-8013;MetaCyc: PWY-7238;MetaCyc: PWY-621;KEGG: 00010+5.3.1.9;Reactome: R-HSA-70263;KEGG: 00520+5.3.1.9;MetaCyc: PWY-7347;MetaCyc: PWY-5659;MetaCyc: PWY-5514;MetaCyc: PWY-5054	"Starch and sucrose metabolism";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"TP53 Regulates Metabolic Genes";"Chitin biosynthesis";"Starch biosynthesis";"Pentose phosphate pathway";"1,5-anhydrofructose degradation";"Glycolysis";"Sucrose degradation IV (sucrose phosphorylase)";"Neutrophil degranulation";"Sucrose degradation II (sucrose synthase)";"1,3-propanediol biosynthesis (engineered)";"UDP-N-acetyl-D-galactosamine biosynthesis III";"Sucrose biosynthesis II";"Sucrose degradation III (sucrose invertase)";"Glycolysis / Gluconeogenesis";"Gluconeogenesis";"Amino sugar and nucleotide sugar metabolism";"Sucrose biosynthesis III";"GDP-mannose biosynthesis";"UDP-N-acetyl-D-galactosamine biosynthesis II";"D-sorbitol biosynthesis I"
XP_046426387.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046430383.1	7	Reactome: R-HSA-1632852;Reactome: R-HSA-166208;Reactome: R-HSA-380972;Reactome: R-HSA-165159;Reactome: R-HSA-5628897;Reactome: R-HSA-9639288;Reactome: R-HSA-8943724	"Macroautophagy";"mTORC1-mediated signalling";"Energy dependent regulation of mTOR by LKB1-AMPK";"mTOR signalling";"TP53 Regulates Metabolic Genes";"Amino acids regulate mTORC1";"Regulation of PTEN gene transcription"
XP_046428806.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_046422575.1	5	KEGG: 00330+1.5.1.2;MetaCyc: PWY-4981;MetaCyc: PWY-6344;Reactome: R-HSA-8964539;MetaCyc: PWY-3341	"Arginine and proline metabolism";"L-proline biosynthesis II (from arginine)";"L-ornithine degradation II (Stickland reaction)";"Glutamate and glutamine metabolism";"L-proline biosynthesis III (from L-ornithine)"
XP_046425196.1	1	Reactome: R-HSA-418990	"Adherens junctions interactions"
XP_046435482.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_046417831.1	4	Reactome: R-HSA-196757;KEGG: 00670+1.5.1.6;KEGG: 00970+2.1.2.9;KEGG: 00670+2.1.2.9	"Metabolism of folate and pterines";"One carbon pool by folate";"Aminoacyl-tRNA biosynthesis";"One carbon pool by folate"
XP_046412335.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_046427068.1	3	Reactome: R-HSA-977347;KEGG: 00680+3.1.3.3;KEGG: 00260+3.1.3.3	"Serine biosynthesis";"Methane metabolism";"Glycine, serine and threonine metabolism"
XP_046432295.1	4	MetaCyc: PWY-5691;KEGG: 00230+4.1.1.97;MetaCyc: PWY-7849;MetaCyc: PWY-7394	"Urate conversion to allantoin I";"Purine metabolism";"Urate conversion to allantoin III";"Urate conversion to allantoin II"
XP_046435859.1	2	Reactome: R-HSA-429947;Reactome: R-HSA-6804115	"Deadenylation of mRNA";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"
XP_046415329.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046414976.1	1	Reactome: R-HSA-71288	"Creatine metabolism"
XP_046431425.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046417278.1	2	Reactome: R-HSA-1660662;Reactome: R-HSA-390471	"Glycosphingolipid metabolism";"Association of TriC/CCT with target proteins during biosynthesis"
XP_046423852.1	1	Reactome: R-HSA-71384	"Ethanol oxidation"
XP_046418501.1	4	Reactome: R-HSA-76066;Reactome: R-HSA-76061;Reactome: R-HSA-76071;Reactome: R-HSA-749476	"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Abortive And Retractive Initiation"
XP_046433139.1	1	Reactome: R-HSA-8949664	"Processing of SMDT1"
XP_046413471.1	9	Reactome: R-HSA-1368082;Reactome: R-HSA-400253;Reactome: R-HSA-400206;Reactome: R-HSA-1989781;Reactome: R-HSA-1368108;Reactome: R-HSA-2426168;Reactome: R-HSA-2151201;Reactome: R-HSA-5617472;Reactome: R-HSA-381340	"RORA activates gene expression";"Circadian Clock";"Regulation of lipid metabolism by PPARalpha";"PPARA activates gene expression";"BMAL1:CLOCK,NPAS2 activates circadian gene expression";"Activation of gene expression by SREBF (SREBP)";"Transcriptional activation of mitochondrial biogenesis";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Transcriptional regulation of white adipocyte differentiation"
XP_046434580.1	3	Reactome: R-HSA-418597;KEGG: 04070+2.7.11.13;Reactome: R-HSA-114508	"G alpha (z) signalling events";"Phosphatidylinositol signaling system";"Effects of PIP2 hydrolysis"
XP_046409676.1	5	Reactome: R-HSA-983712;Reactome: R-HSA-917977;Reactome: R-HSA-9639288;Reactome: R-HSA-1222556;Reactome: R-HSA-77387	"Ion channel transport";"Transferrin endocytosis and recycling";"Amino acids regulate mTORC1";"ROS and RNS production in phagocytes";"Insulin receptor recycling"
XP_046421519.1	3	Reactome: R-HSA-6811438;Reactome: R-HSA-6811440;Reactome: R-HSA-6807878	"Intra-Golgi traffic";"Retrograde transport at the Trans-Golgi-Network";"COPI-mediated anterograde transport"
XP_046410924.1	14	MetaCyc: PWY-5080;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7601;MetaCyc: PWY-7619;MetaCyc: PWY-7725;MetaCyc: PWY-7035;MetaCyc: PWY-8041;MetaCyc: PWY-7036;MetaCyc: PWY-6598;MetaCyc: PWY-7602;MetaCyc: PWY-6433;MetaCyc: PWY-7724;MetaCyc: PWY-5972;Reactome: R-HSA-75876	"Very long chain fatty acid biosynthesis I";"Fatty acid elongation";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Juniperonate biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"(9Z)-tricosene biosynthesis";"Ultra-long-chain fatty acid biosynthesis";"Very long chain fatty acid biosynthesis II";"Sciadonate biosynthesis";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Hydroxylated fatty acid biosynthesis (plants)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Stearate biosynthesis I (animals)";"Synthesis of very long-chain fatty acyl-CoAs"
XP_046426542.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_046421168.1	9	Reactome: R-HSA-1483166;MetaCyc: PWY-7411;MetaCyc: PWY-6118;MetaCyc: PWY-7902;MetaCyc: PWY-5667;KEGG: 00564+1.1.1.8;KEGG: 00564+1.1.1.94;MetaCyc: PWY-7385;MetaCyc: PWY-5981	"Synthesis of PA";"Phosphatidate biosynthesis (yeast)";"Glycerol-3-phosphate shuttle";"Glucosylglycerol biosynthesis";"CDP-diacylglycerol biosynthesis I";"Glycerophospholipid metabolism";"Glycerophospholipid metabolism";"1,3-propanediol biosynthesis (engineered)";"CDP-diacylglycerol biosynthesis III"
XP_046435339.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_046413251.1	1	Reactome: R-HSA-6811440	"Retrograde transport at the Trans-Golgi-Network"
XP_046416037.1	1	Reactome: R-HSA-6790901	"rRNA modification in the nucleus and cytosol"
XP_046412130.1	2	Reactome: R-HSA-75105;KEGG: 00062+3.1.2.22	"Fatty acyl-CoA biosynthesis";"Fatty acid elongation"
XP_046433253.1	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
XP_046420801.1	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
XP_046425885.1	1	Reactome: R-HSA-1971475	"A tetrasaccharide linker sequence is required for GAG synthesis"
XP_046421497.1	12	MetaCyc: PWY-7233;MetaCyc: PWY-5856;MetaCyc: PWY-5870;KEGG: 00130+2.1.1.222+2.1.1.64;MetaCyc: PWY-5855;MetaCyc: PWY-5857;MetaCyc: PWY-7230;MetaCyc: PWY-6708;MetaCyc: PWY-5871;MetaCyc: PWY-5873;Reactome: R-HSA-2142789;MetaCyc: PWY-5872	"Ubiquinol-6 bypass biosynthesis (eukaryotic)";"Ubiquinol-9 biosynthesis (prokaryotic)";"Ubiquinol-8 biosynthesis (eukaryotic)";"Ubiquinone and other terpenoid-quinone biosynthesis";"Ubiquinol-7 biosynthesis (prokaryotic)";"Ubiquinol-10 biosynthesis (prokaryotic)";"Ubiquinol-6 biosynthesis from 4-aminobenzoate (yeast)";"Ubiquinol-8 biosynthesis (prokaryotic)";"Ubiquinol-9 biosynthesis (eukaryotic)";"Ubiquinol-7 biosynthesis (eukaryotic)";"Ubiquinol biosynthesis";"Ubiquinol-10 biosynthesis (eukaryotic)"
XP_046418437.1	1	Reactome: R-HSA-3238698	"WNT ligand biogenesis and trafficking"
XP_046433535.1	11	Reactome: R-HSA-2151201;Reactome: R-HSA-111459;Reactome: R-HSA-1268020;Reactome: R-HSA-9627069;Reactome: R-HSA-3299685;Reactome: R-HSA-111457;Reactome: R-HSA-111463;Reactome: R-HSA-111464;Reactome: R-HSA-611105;Reactome: R-HSA-111458;Reactome: R-HSA-5628897	"Transcriptional activation of mitochondrial biogenesis";"Activation of caspases through apoptosome-mediated cleavage";"Mitochondrial protein import";"Regulation of the apoptosome activity";"Detoxification of Reactive Oxygen Species";"Release of apoptotic factors from the mitochondria";"SMAC (DIABLO) binds to IAPs";"SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes";"Respiratory electron transport";"Formation of apoptosome";"TP53 Regulates Metabolic Genes"
XP_046418835.1	1	Reactome: R-HSA-83936	"Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"
XP_046418144.1	1	Reactome: R-HSA-1445148	"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
XP_046410493.1	1	Reactome: R-HSA-5389840	"Mitochondrial translation elongation"
XP_046427435.1	13	Reactome: R-HSA-192823;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-72689;Reactome: R-HSA-1799339;Reactome: R-HSA-2408557;Reactome: R-HSA-72706;Reactome: R-HSA-6791226;Reactome: R-HSA-975957;Reactome: R-HSA-72764;Reactome: R-HSA-975956;Reactome: R-HSA-156902	"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Formation of a pool of free 40S subunits";"SRP-dependent cotranslational protein targeting to membrane";"Selenocysteine synthesis";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Peptide chain elongation"
XP_046431324.1	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
XP_046409939.1	2	Reactome: R-HSA-71403;Reactome: R-HSA-611105	"Citric acid cycle (TCA cycle)";"Respiratory electron transport"
XP_046414344.1	13	MetaCyc: PWY-8052;MetaCyc: PWY-6367;KEGG: 04070+3.1.4.11;Reactome: R-HSA-2029485;Reactome: R-HSA-9027277;Reactome: R-HSA-2871796;Reactome: R-HSA-1855204;KEGG: 00562+3.1.4.11;Reactome: R-HSA-202433;Reactome: R-HSA-2871809;Reactome: R-HSA-2424491;MetaCyc: PWY-7039;MetaCyc: PWY-6351	"2-arachidonoylglycerol biosynthesis";"D-myo-inositol-5-phosphate metabolism";"Phosphatidylinositol signaling system";"Role of phospholipids in phagocytosis";"Erythropoietin activates Phospholipase C gamma (PLCG)";"FCERI mediated MAPK activation";"Synthesis of IP3 and IP4 in the cytosol";"Inositol phosphate metabolism";"Generation of second messenger molecules";"FCERI mediated Ca+2 mobilization";"DAP12 signaling";"Phosphatidate metabolism, as a signaling molecule";"D-myo-inositol (1,4,5)-trisphosphate biosynthesis"
XP_046414917.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_046414517.1	31	MetaCyc: PWY-6799;MetaCyc: PWY-4381;MetaCyc: PWY-7388;MetaCyc: PWY-5966-1;MetaCyc: PWY-5142;MetaCyc: PWY-7664;KEGG: 00780+1.1.1.100+4.2.1.59+2.3.1.41;MetaCyc: PWY-5367;MetaCyc: PWYG-321;MetaCyc: PWY-8049;MetaCyc: PWY-8012;Reactome: R-HSA-199220;Reactome: R-HSA-2426168;Reactome: R-HSA-9029558;MetaCyc: PWY-7858;MetaCyc: PWY-5989;MetaCyc: PWY-5147;MetaCyc: PWY-7723;MetaCyc: PWY-7746;KEGG: 00061+1.1.1.100+2.3.1.85+4.2.1.59+2.3.1.39+2.3.1.41+3.1.2.14;MetaCyc: PWY-5973;MetaCyc: PWY-8047;MetaCyc: PWY-6282;Reactome: R-HSA-75105;MetaCyc: PWY-5366;MetaCyc: PWY-7663;MetaCyc: PWY-6519;Reactome: R-HSA-163765;MetaCyc: PWY-5971;MetaCyc: PWY-5994;MetaCyc: PWY-6113	"Fatty acid biosynthesis initiation (plant mitochondria)";"Fatty acid biosynthesis initiation (bacteria and plants)";"Octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast)";"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)";"Acyl-[acyl-carrier protein] thioesterase pathway";"Oleate biosynthesis IV (anaerobic)";"Biotin metabolism";"Petroselinate biosynthesis";"";"Pederin biosynthesis";"Mupirocin biosynthesis";"Vitamin B5 (pantothenate) metabolism";"Activation of gene expression by SREBF (SREBP)";"NR1H2 & NR1H3 regulate gene expression linked to lipogenesis";"(5Z)-dodecenoate biosynthesis II";"Stearate biosynthesis II (bacteria and plants)";"Oleate biosynthesis I (plants)";"Bacterial bioluminescence";"Mycobacterial sulfolipid biosynthesis";"Fatty acid biosynthesis";"Cis-vaccenate biosynthesis";"Bryostatin biosynthesis";"Palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate)";"Fatty acyl-CoA biosynthesis";"Palmitoleate biosynthesis II (plants and bacteria)";"Gondoate biosynthesis (anaerobic)";"8-amino-7-oxononanoate biosynthesis I";"ChREBP activates metabolic gene expression";"Palmitate biosynthesis II (bacteria and plant cytoplasm)";"Palmitate biosynthesis (animals and fungi, cytoplasm)";"Superpathway of mycolate biosynthesis"
XP_046414885.1	5	Reactome: R-HSA-6811440;Reactome: R-HSA-6807878;Reactome: R-HSA-6811438;Reactome: R-HSA-6811434;Reactome: R-HSA-204005	"Retrograde transport at the Trans-Golgi-Network";"COPI-mediated anterograde transport";"Intra-Golgi traffic";"COPI-dependent Golgi-to-ER retrograde traffic";"COPII-mediated vesicle transport"
XP_046418832.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046428084.1	4	Reactome: R-HSA-418359;Reactome: R-HSA-1912420;Reactome: R-HSA-936837;Reactome: R-HSA-5578775	"Reduction of cytosolic Ca++ levels";"Pre-NOTCH Processing in Golgi";"Ion transport by P-type ATPases";"Ion homeostasis"
XP_046415611.1	14	MetaCyc: PWY-7417;MetaCyc: PWY-8053;MetaCyc: PWY-5981;MetaCyc: PWY-7589;MetaCyc: PWY-7782;MetaCyc: PWY-7587;MetaCyc: PWY-7411;Reactome: R-HSA-1483166;MetaCyc: PWY-5667;MetaCyc: PWY-8055;KEGG: 00561+2.3.1.51;MetaCyc: PWY-8051;KEGG: 00564+2.3.1.51;MetaCyc: PWY-6453	"Phospholipid remodeling (phosphatidate, yeast)";"Anandamide biosynthesis II";"CDP-diacylglycerol biosynthesis III";"Palmitoleate biosynthesis III (cyanobacteria)";"Plasmalogen biosynthesis";"Oleate biosynthesis III (cyanobacteria)";"Phosphatidate biosynthesis (yeast)";"Synthesis of PA";"CDP-diacylglycerol biosynthesis I";"Palmitoyl ethanolamide biosynthesis";"Glycerolipid metabolism";"Anandamide biosynthesis I";"Glycerophospholipid metabolism";"Stigma estolide biosynthesis"
XP_046425786.1	2	MetaCyc: PWY-6854;Reactome: R-HSA-3299685	"Ethylene biosynthesis III (microbes)";"Detoxification of Reactive Oxygen Species"
XP_046424650.1	1	Reactome: R-HSA-6787450	"tRNA modification in the mitochondrion"
XP_046410858.1	4	Reactome: R-HSA-73856;Reactome: R-HSA-72163;Reactome: R-HSA-72187;Reactome: R-HSA-159236	"RNA Polymerase II Transcription Termination";"mRNA Splicing - Major Pathway";"mRNA 3'-end processing";"Transport of Mature mRNA derived from an Intron-Containing Transcript"
XP_046411889.1	1	Reactome: R-HSA-425986	"Sodium/Proton exchangers"
XP_046429826.1	8	KEGG: 00524+2.7.1.1;KEGG: 00521+2.7.1.1;KEGG: 00051+2.7.1.1;KEGG: 00520+2.7.1.1;KEGG: 00010+2.7.1.1;Reactome: R-HSA-70171;KEGG: 00052+2.7.1.1;KEGG: 00500+2.7.1.1	"Neomycin, kanamycin and gentamicin biosynthesis";"Streptomycin biosynthesis";"Fructose and mannose metabolism";"Amino sugar and nucleotide sugar metabolism";"Glycolysis / Gluconeogenesis";"Glycolysis";"Galactose metabolism";"Starch and sucrose metabolism"
XP_046411126.1	1	Reactome: R-HSA-420029	"Tight junction interactions"
XP_046426421.1	9	Reactome: R-HSA-9613829;Reactome: R-HSA-9615710;Reactome: R-HSA-8856825;Reactome: R-HSA-5689880;Reactome: R-HSA-9646399;Reactome: R-HSA-382556;Reactome: R-HSA-5627083;Reactome: R-HSA-8856828;Reactome: R-HSA-5678895	"Chaperone Mediated Autophagy";"Late endosomal microautophagy";"Cargo recognition for clathrin-mediated endocytosis";"Ub-specific processing proteases";"Aggrephagy";"ABC-family proteins mediated transport";"RHO GTPases regulate CFTR trafficking";"Clathrin-mediated endocytosis";"Defective CFTR causes cystic fibrosis"
XP_046415233.1	4	Reactome: R-HSA-2500257;Reactome: R-HSA-2470946;Reactome: R-HSA-2468052;Reactome: R-HSA-2467813	"Resolution of Sister Chromatid Cohesion";"Cohesin Loading onto Chromatin";"Establishment of Sister Chromatid Cohesion";"Separation of Sister Chromatids"
XP_046418072.1	4	MetaCyc: PWY-5737;Reactome: R-HSA-70688;KEGG: 00330+1.5.5.2;MetaCyc: PWY-6922	"(5R)-carbapenem carboxylate biosynthesis";"Proline catabolism";"Arginine and proline metabolism";"L-Ndelta-acetylornithine biosynthesis"
XP_046436720.1	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
XP_046425136.1	2	Reactome: R-HSA-8949664;Reactome: R-HSA-8949215	"Processing of SMDT1";"Mitochondrial calcium ion transport"
XP_046417194.1	2	Reactome: R-HSA-1799339;Reactome: R-HSA-381038	"SRP-dependent cotranslational protein targeting to membrane";"XBP1(S) activates chaperone genes"
XP_046425524.1	13	KEGG: 00240+1.17.4.1;MetaCyc: PWY-6545;MetaCyc: PWY-7222;MetaCyc: PWY-7184;MetaCyc: PWY-7210;Reactome: R-HSA-499943;MetaCyc: PWY-7227;MetaCyc: PWY-7198;MetaCyc: PWY-7226;KEGG: 00480+1.17.4.1;KEGG: 00230+1.17.4.1;KEGG: 00983+1.17.4.1;MetaCyc: PWY-7220	"Pyrimidine metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Guanosine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Interconversion of nucleotide di- and triphosphates";"Adenosine deoxyribonucleotides de novo biosynthesis";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Guanosine deoxyribonucleotides de novo biosynthesis I";"Glutathione metabolism";"Purine metabolism";"Drug metabolism - other enzymes";"Adenosine deoxyribonucleotides de novo biosynthesis II"
XP_046414293.1	1	MetaCyc: PWY-7942	"5-oxo-L-proline metabolism"
XP_046417357.1	16	Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-72706;Reactome: R-HSA-2408557;Reactome: R-HSA-6791226;Reactome: R-HSA-975956;Reactome: R-HSA-72702;Reactome: R-HSA-72689;Reactome: R-HSA-192823;Reactome: R-HSA-72695;Reactome: R-HSA-1799339;Reactome: R-HSA-975957;Reactome: R-HSA-156902;Reactome: R-HSA-72649;Reactome: R-HSA-72764	"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Selenocysteine synthesis";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Ribosomal scanning and start codon recognition";"Formation of a pool of free 40S subunits";"Viral mRNA Translation";"Formation of the ternary complex, and subsequently, the 43S complex";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Peptide chain elongation";"Translation initiation complex formation";"Eukaryotic Translation Termination"
XP_046424398.1	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
XP_046430978.1	4	KEGG: 04658+3.1.3.16;Reactome: R-HSA-180024;KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16	"Th1 and Th2 cell differentiation";"DARPP-32 events";"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
XP_046416850.1	6	MetaCyc: PWY-7656;KEGG: 00073+1.2.1.84;Reactome: R-HSA-9640463;MetaCyc: PWY-6733;MetaCyc: PWY-7782;MetaCyc: PWY-5884	"Spodoptera littoralis pheromone biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax biosynthesis";"Sporopollenin precursors biosynthesis";"Plasmalogen biosynthesis";"Wax esters biosynthesis I"
XP_046422096.1	1	Reactome: R-HSA-6804754	"Regulation of TP53 Expression"
XP_046428059.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_046431496.1	4	Reactome: R-HSA-8939211;Reactome: R-HSA-3371497;Reactome: R-HSA-9018519;Reactome: R-HSA-3371568	"ESR-mediated signaling";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Estrogen-dependent gene expression";"Attenuation phase"
XP_046427795.1	1	Reactome: R-HSA-196819	"Vitamin B1 (thiamin) metabolism"
XP_046419810.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046433761.1	6	Reactome: R-HSA-191859;Reactome: R-HSA-72163;Reactome: R-HSA-73856;Reactome: R-HSA-77588;Reactome: R-HSA-111367;Reactome: R-HSA-72165	"snRNP Assembly";"mRNA Splicing - Major Pathway";"RNA Polymerase II Transcription Termination";"SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs";"SLBP independent Processing of Histone Pre-mRNAs";"mRNA Splicing - Minor Pathway"
XP_046420935.1	3	Reactome: R-HSA-212436;Reactome: R-HSA-1989781;Reactome: R-HSA-381340	"Generic Transcription Pathway";"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation"
XP_046419258.1	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
XP_046434480.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046431720.1	1	Reactome: R-HSA-2151201	"Transcriptional activation of mitochondrial biogenesis"
XP_046414166.1	1	Reactome: R-HSA-8849932	"Synaptic adhesion-like molecules"
XP_046418393.1	1	Reactome: R-HSA-204005	"COPII-mediated vesicle transport"
XP_046425634.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_046435379.1	2	Reactome: R-HSA-8856825;Reactome: R-HSA-8856828	"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis"
XP_046424935.1	1	Reactome: R-HSA-432720	"Lysosome Vesicle Biogenesis"
XP_046420502.1	1	Reactome: R-HSA-428359	"Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA"
XP_046416712.1	2	Reactome: R-HSA-9029569;Reactome: R-HSA-804914	"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Transport of fatty acids"
XP_046428383.1	2	Reactome: R-HSA-8876198;Reactome: R-HSA-204005	"RAB GEFs exchange GTP for GDP on RABs";"COPII-mediated vesicle transport"
XP_046422400.1	13	KEGG: 00640+6.2.1.5;MetaCyc: PWY-6728;MetaCyc: PWY-5913;MetaCyc: PWY-5538;MetaCyc: PWY-6969;MetaCyc: PWY-5537;KEGG: 00720+6.2.1.5;MetaCyc: PWY-5392;KEGG: 00660+6.2.1.5;Reactome: R-HSA-71403;MetaCyc: PWY-7384;MetaCyc: PWY-5690;KEGG: 00020+6.2.1.5	"Propanoate metabolism";"Methylaspartate cycle";"Partial TCA cycle (obligate autotrophs)";"Pyruvate fermentation to acetate VI";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Pyruvate fermentation to acetate V";"Carbon fixation pathways in prokaryotes";"Reductive TCA cycle II";"C5-Branched dibasic acid metabolism";"Citric acid cycle (TCA cycle)";"Anaerobic energy metabolism (invertebrates, mitochondrial)";"TCA cycle II (plants and fungi)";"Citrate cycle (TCA cycle)"
XP_046414493.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_046412014.1	1	Reactome: R-HSA-6803157	"Antimicrobial peptides"
XP_046416976.1	1	Reactome: R-HSA-6794361	"Neurexins and neuroligins"
XP_046427977.1	14	Reactome: R-HSA-5687128;Reactome: R-HSA-9022692;Reactome: R-HSA-203927;Reactome: R-HSA-426496;Reactome: R-HSA-9029569;Reactome: R-HSA-426486;Reactome: R-HSA-8934593;Reactome: R-HSA-9018519;Reactome: R-HSA-5628897;Reactome: R-HSA-8948700;Reactome: R-HSA-4086398;Reactome: R-HSA-8986944;Reactome: R-HSA-8943723;Reactome: R-HSA-1912408	"MAPK6/MAPK4 signaling";"Regulation of MECP2 expression and activity";"MicroRNA (miRNA) biogenesis";"Post-transcriptional silencing by small RNAs";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Small interfering RNA (siRNA) biogenesis";"Regulation of RUNX1 Expression and Activity";"Estrogen-dependent gene expression";"TP53 Regulates Metabolic Genes";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"Ca2+ pathway";"Transcriptional Regulation by MECP2";"Regulation of PTEN mRNA translation";"Pre-NOTCH Transcription and Translation"
XP_046426763.1	4	Reactome: R-HSA-6798163;KEGG: 00260+1.2.1.8+1.1.99.1;MetaCyc: PWY-7494;MetaCyc: PWY-3722	"Choline catabolism";"Glycine, serine and threonine metabolism";"Choline degradation IV";"Glycine betaine biosynthesis II (Gram-positive bacteria)"
XP_046427493.1	2	Reactome: R-HSA-5576893;Reactome: R-HSA-5576892	"Phase 2 - plateau phase";"Phase 0 - rapid depolarisation"
XP_046419685.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_046431869.1	8	Reactome: R-HSA-5099900;Reactome: R-HSA-8856825;Reactome: R-HSA-5140745;Reactome: R-HSA-190873;Reactome: R-HSA-196025;Reactome: R-HSA-432720;Reactome: R-HSA-3928665;Reactome: R-HSA-8856828	"WNT5A-dependent internalization of FZD4";"Cargo recognition for clathrin-mediated endocytosis";"WNT5A-dependent internalization of FZD2, FZD5 and ROR2";"Gap junction degradation";"Formation of annular gap junctions";"Lysosome Vesicle Biogenesis";"EPH-ephrin mediated repulsion of cells";"Clathrin-mediated endocytosis"
XP_046413966.1	2	Reactome: R-HSA-6784531;Reactome: R-HSA-6791226	"tRNA processing in the nucleus";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046415571.1	4	Reactome: R-HSA-2395516;Reactome: R-HSA-211976;Reactome: R-HSA-5579026;Reactome: R-HSA-196108	"Electron transport from NADPH to Ferredoxin";"Endogenous sterols";"Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)";"Pregnenolone biosynthesis"
XP_046419228.1	3	Reactome: R-HSA-5656121;Reactome: R-HSA-5655862;Reactome: R-HSA-110312	"Translesion synthesis by POLI";"Translesion synthesis by POLK";"Translesion synthesis by REV1"
XP_046429092.1	19	Reactome: R-HSA-8856825;Reactome: R-HSA-8856828;Reactome: R-HSA-432142;Reactome: R-HSA-8963901;Reactome: R-HSA-8964026;Reactome: R-HSA-8964038;Reactome: R-HSA-8957275;Reactome: R-HSA-8963888;Reactome: R-HSA-8866423;Reactome: R-HSA-3000497;Reactome: R-HSA-3000480;Reactome: R-HSA-8964041;Reactome: R-HSA-3000484;Reactome: R-HSA-381426;Reactome: R-HSA-975634;Reactome: R-HSA-202733;Reactome: R-HSA-8964046;Reactome: R-HSA-5686938;Reactome: R-HSA-3000471	"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis";"Platelet sensitization by LDL";"Chylomicron remodeling";"Chylomicron clearance";"LDL clearance";"Post-translational protein phosphorylation";"Chylomicron assembly";"VLDL assembly";"Scavenging by Class H Receptors";"Scavenging by Class A Receptors";"LDL remodeling";"Scavenging by Class F Receptors";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"Retinoid metabolism and transport";"Cell surface interactions at the vascular wall";"VLDL clearance";"Regulation of TLR by endogenous ligand";"Scavenging by Class B Receptors"
XP_046410850.1	3	Reactome: R-HSA-76066;Reactome: R-HSA-76061;Reactome: R-HSA-749476	"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Abortive And Retractive Initiation"
XP_046431671.1	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
XP_046414200.1	1	Reactome: R-HSA-5620912	"Anchoring of the basal body to the plasma membrane"
XP_046427733.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_046411362.1	5	MetaCyc: PWY-7269;KEGG: 00760+2.7.1.23;MetaCyc: PWY-7268;Reactome: R-HSA-196807;MetaCyc: PWY-5083	"NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)";"Nicotinate and nicotinamide metabolism";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"Nicotinate metabolism";"NAD/NADH phosphorylation and dephosphorylation"
XP_046411188.1	2	Reactome: R-HSA-5663220;Reactome: R-HSA-376176	"RHO GTPases Activate Formins";"Signaling by ROBO receptors"
XP_046431966.1	2	Reactome: R-HSA-176187;Reactome: R-HSA-68962	"Activation of ATR in response to replication stress";"Activation of the pre-replicative complex"
XP_046413297.1	4	Reactome: R-HSA-418594;Reactome: R-HSA-201681;Reactome: R-HSA-5689880;Reactome: R-HSA-4641257	"G alpha (i) signalling events";"TCF dependent signaling in response to WNT";"Ub-specific processing proteases";"Degradation of AXIN"
XP_046421704.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_046436508.1	2	Reactome: R-HSA-8853383;KEGG: 00511+3.2.1.24	"Lysosomal oligosaccharide catabolism";"Other glycan degradation"
XP_046428136.1	2	Reactome: R-HSA-195253;Reactome: R-HSA-5689896	"Degradation of beta-catenin by the destruction complex";"Ovarian tumor domain proteases"
XP_046419906.1	4	Reactome: R-HSA-917977;Reactome: R-HSA-1222556;Reactome: R-HSA-77387;Reactome: R-HSA-983712	"Transferrin endocytosis and recycling";"ROS and RNS production in phagocytes";"Insulin receptor recycling";"Ion channel transport"
XP_046433586.1	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_046423456.1	19	Reactome: R-HSA-182971;Reactome: R-HSA-2029482;Reactome: R-HSA-5627123;Reactome: R-HSA-418885;Reactome: R-HSA-8964616;Reactome: R-HSA-5687128;Reactome: R-HSA-5663220;Reactome: R-HSA-8950505;Reactome: R-HSA-5625970;Reactome: R-HSA-983231;Reactome: R-HSA-4420097;Reactome: R-HSA-5663213;Reactome: R-HSA-114604;Reactome: R-HSA-525793;Reactome: R-HSA-5626467;Reactome: R-HSA-194840;Reactome: R-HSA-428543;Reactome: R-HSA-389359;Reactome: R-HSA-3928662	"EGFR downregulation";"Regulation of actin dynamics for phagocytic cup formation";"RHO GTPases activate PAKs";"DCC mediated attractive signaling";"G beta:gamma signalling through CDC42";"MAPK6/MAPK4 signaling";"RHO GTPases Activate Formins";"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation";"RHO GTPases activate KTN1";"Factors involved in megakaryocyte development and platelet production";"VEGFA-VEGFR2 Pathway";"RHO GTPases Activate WASPs and WAVEs";"GPVI-mediated activation cascade";"Myogenesis";"RHO GTPases activate IQGAPs";"Rho GTPase cycle";"Inactivation of CDC42 and RAC1";"CD28 dependent Vav1 pathway";"EPHB-mediated forward signaling"
XP_046424429.1	1	Reactome: R-HSA-2467813	"Separation of Sister Chromatids"
XP_046428458.1	18	KEGG: 00591+3.1.1.4;KEGG: 00564+3.1.1.4;MetaCyc: PWY-7409;MetaCyc: PWY-7416;Reactome: R-HSA-1482839;MetaCyc: PWY-8053;MetaCyc: PWY-7783;MetaCyc: PWY-6803;Reactome: R-HSA-1482925;Reactome: R-HSA-1482801;MetaCyc: PWY-7417;KEGG: 00590+3.1.1.4;Reactome: R-HSA-1483166;KEGG: 00592+3.1.1.4;MetaCyc: PWY-8051;Reactome: R-HSA-1482922;KEGG: 00565+3.1.1.4;Reactome: R-HSA-1482788	"Linoleic acid metabolism";"Glycerophospholipid metabolism";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Acyl chain remodelling of PE";"Anandamide biosynthesis II";"Plasmalogen degradation";"Phosphatidylcholine acyl editing";"Acyl chain remodelling of PG";"Acyl chain remodelling of PS";"Phospholipid remodeling (phosphatidate, yeast)";"Arachidonic acid metabolism";"Synthesis of PA";"alpha-Linolenic acid metabolism";"Anandamide biosynthesis I";"Acyl chain remodelling of PI";"Ether lipid metabolism";"Acyl chain remodelling of PC"
XP_046417702.1	1	Reactome: R-HSA-432047	"Passive transport by Aquaporins"
XP_046416921.1	14	MetaCyc: PWY-7409;MetaCyc: PWY-7416;MetaCyc: PWY-8053;KEGG: 00591+3.1.1.4;MetaCyc: PWY-7417;KEGG: 00564+3.1.1.4+3.1.1.5;MetaCyc: PWY-8051;MetaCyc: PWY-6803;Reactome: R-HSA-1482788;KEGG: 00565+3.1.1.4;Reactome: R-HSA-975634;KEGG: 00590+3.1.1.4;MetaCyc: PWY-7783;KEGG: 00592+3.1.1.4	"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Anandamide biosynthesis II";"Linoleic acid metabolism";"Phospholipid remodeling (phosphatidate, yeast)";"Glycerophospholipid metabolism";"Anandamide biosynthesis I";"Phosphatidylcholine acyl editing";"Acyl chain remodelling of PC";"Ether lipid metabolism";"Retinoid metabolism and transport";"Arachidonic acid metabolism";"Plasmalogen degradation";"alpha-Linolenic acid metabolism"
XP_046434259.1	3	Reactome: R-HSA-416482;Reactome: R-HSA-194840;Reactome: R-HSA-193648	"G alpha (12/13) signalling events";"Rho GTPase cycle";"NRAGE signals death through JNK"
XP_046411588.1	7	Reactome: R-HSA-1834949;Reactome: R-HSA-749476;Reactome: R-HSA-76071;Reactome: R-HSA-73780;Reactome: R-HSA-73980;Reactome: R-HSA-76061;Reactome: R-HSA-76066	"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Chain Elongation";"RNA Polymerase III Transcription Termination";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Transcription Initiation From Type 2 Promoter"
XP_046433801.1	5	Reactome: R-HSA-901032;Reactome: R-HSA-381038;Reactome: R-HSA-5358346;Reactome: R-HSA-5362768;MetaCyc: PWY-7511	"ER Quality Control Compartment (ERQC)";"XBP1(S) activates chaperone genes";"Hedgehog ligand biogenesis";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Protein ubiquitination"
XP_046419719.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046420152.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_046415784.1	2	Reactome: R-HSA-379726;KEGG: 00970+6.1.1.20	"Mitochondrial tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis"
XP_046428776.1	7	KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1	"Thermogenesis";"Human cytomegalovirus infection";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Relaxin signaling pathway";"mTOR signaling pathway";"PI3K-Akt signaling pathway"
XP_046416111.1	5	Reactome: R-HSA-5693568;Reactome: R-HSA-5693579;Reactome: R-HSA-5685942;Reactome: R-HSA-5693616;Reactome: R-HSA-5693554	"Resolution of D-loop Structures through Holliday Junction Intermediates";"Homologous DNA Pairing and Strand Exchange";"HDR through Homologous Recombination (HRR)";"Presynaptic phase of homologous DNA pairing and strand exchange";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)"
XP_046423899.1	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
XP_046426478.1	1	Reactome: R-HSA-3299685	"Detoxification of Reactive Oxygen Species"
XP_046410167.1	1	Reactome: R-HSA-77289	"Mitochondrial Fatty Acid Beta-Oxidation"
XP_046433909.1	1	Reactome: R-HSA-8876725	"Protein methylation"
XP_046420242.1	20	Reactome: R-HSA-71403;MetaCyc: PWY-5690;MetaCyc: PWY-7384;KEGG: 00020+6.2.1.5;MetaCyc: PWY-5392;KEGG: 00660+6.2.1.5;KEGG: 00640+6.2.1.5;MetaCyc: PWY-5913;KEGG: 00020+2.3.3.8;Reactome: R-HSA-75105;KEGG: 00720+2.3.3.8;MetaCyc: PWY-5537;KEGG: 00720+6.2.1.5;MetaCyc: PWY-5172;Reactome: R-HSA-163765;Reactome: R-HSA-6798695;MetaCyc: PWY-5538;Reactome: R-HSA-1268020;MetaCyc: PWY-6969;MetaCyc: PWY-6728	"Citric acid cycle (TCA cycle)";"TCA cycle II (plants and fungi)";"Anaerobic energy metabolism (invertebrates, mitochondrial)";"Citrate cycle (TCA cycle)";"Reductive TCA cycle II";"C5-Branched dibasic acid metabolism";"Propanoate metabolism";"Partial TCA cycle (obligate autotrophs)";"Citrate cycle (TCA cycle)";"Fatty acyl-CoA biosynthesis";"Carbon fixation pathways in prokaryotes";"Pyruvate fermentation to acetate V";"Carbon fixation pathways in prokaryotes";"Acetyl-coa biosynthesis III (from citrate)";"ChREBP activates metabolic gene expression";"Neutrophil degranulation";"Pyruvate fermentation to acetate VI";"Mitochondrial protein import";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Methylaspartate cycle"
XP_046436668.1	12	Reactome: R-HSA-5663220;Reactome: R-HSA-2500257;Reactome: R-HSA-6807878;Reactome: R-HSA-3371497;Reactome: R-HSA-2132295;Reactome: R-HSA-68877;Reactome: R-HSA-9609690;Reactome: R-HSA-9646399;Reactome: R-HSA-2467813;Reactome: R-HSA-6811436;Reactome: R-HSA-9648025;Reactome: R-HSA-141444	"RHO GTPases Activate Formins";"Resolution of Sister Chromatid Cohesion";"COPI-mediated anterograde transport";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"MHC class II antigen presentation";"Mitotic Prometaphase";"HCMV Early Events";"Aggrephagy";"Separation of Sister Chromatids";"COPI-independent Golgi-to-ER retrograde traffic";"EML4 and NUDC in mitotic spindle formation";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"
XP_046420228.1	10	Reactome: R-HSA-983231;Reactome: R-HSA-427413;Reactome: R-HSA-9022538;Reactome: R-HSA-3899300;Reactome: R-HSA-9022699;Reactome: R-HSA-9022692;Reactome: R-HSA-8936459;Reactome: R-HSA-9615017;Reactome: R-HSA-400206;Reactome: R-HSA-9022702	"Factors involved in megakaryocyte development and platelet production";"NoRC negatively regulates rRNA expression";"Loss of MECP2 binding ability to 5mC-DNA";"SUMOylation of transcription cofactors";"MECP2 regulates neuronal receptors and channels";"Regulation of MECP2 expression and activity";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"Regulation of lipid metabolism by PPARalpha";"MECP2 regulates transcription of neuronal ligands"
XP_046425886.1	1	Reactome: R-HSA-1971475	"A tetrasaccharide linker sequence is required for GAG synthesis"
XP_046412370.1	32	Reactome: R-HSA-167160;Reactome: R-HSA-73779;Reactome: R-HSA-167238;Reactome: R-HSA-72165;Reactome: R-HSA-167246;Reactome: R-HSA-75953;Reactome: R-HSA-6803529;Reactome: R-HSA-167152;Reactome: R-HSA-167290;Reactome: R-HSA-77075;Reactome: R-HSA-167200;Reactome: R-HSA-6796648;Reactome: R-HSA-167242;Reactome: R-HSA-674695;Reactome: R-HSA-167172;Reactome: R-HSA-167287;Reactome: R-HSA-167158;Reactome: R-HSA-113418;Reactome: R-HSA-167162;Reactome: R-HSA-6807505;Reactome: R-HSA-9018519;Reactome: R-HSA-167161;Reactome: R-HSA-8851708;Reactome: R-HSA-168325;Reactome: R-HSA-73776;Reactome: R-HSA-72086;Reactome: R-HSA-72163;Reactome: R-HSA-167243;Reactome: R-HSA-112382;Reactome: R-HSA-75955;Reactome: R-HSA-76042;Reactome: R-HSA-72203	"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Pausing and recovery of Tat-mediated HIV elongation";"mRNA Splicing - Minor Pathway";"Tat-mediated elongation of the HIV-1 transcript";"RNA Polymerase II Transcription Initiation";"FGFR2 alternative splicing";"Formation of HIV elongation complex in the absence of HIV Tat";"Pausing and recovery of HIV elongation";"RNA Pol II CTD phosphorylation and interaction with CE";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"TP53 Regulates Transcription of DNA Repair Genes";"Abortive elongation of HIV-1 transcript in the absence of Tat";"RNA Polymerase II Pre-transcription Events";"Transcription of the HIV genome";"HIV elongation arrest and recovery";"Formation of the HIV-1 Early Elongation Complex";"Formation of the Early Elongation Complex";"RNA Polymerase II HIV Promoter Escape";"RNA polymerase II transcribes snRNA genes";"Estrogen-dependent gene expression";"HIV Transcription Initiation";"Signaling by FGFR2 IIIa TM";"Viral Messenger RNA Synthesis";"RNA Polymerase II Promoter Escape";"mRNA Capping";"mRNA Splicing - Major Pathway";"Tat-mediated HIV elongation arrest and recovery";"Formation of RNA Pol II elongation complex";"RNA Polymerase II Transcription Elongation";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Processing of Capped Intron-Containing Pre-mRNA"
XP_046415915.1	2	KEGG: 00563+3.5.1.89;Reactome: R-HSA-162710	"Glycosylphosphatidylinositol (GPI)-anchor biosynthesis";"Synthesis of glycosylphosphatidylinositol (GPI)"
XP_046416749.1	1	Reactome: R-HSA-3214842	"HDMs demethylate histones"
XP_046417057.1	2	Reactome: R-HSA-983231;Reactome: R-HSA-383280	"Factors involved in megakaryocyte development and platelet production";"Nuclear Receptor transcription pathway"
XP_046434520.1	33	Reactome: R-HSA-168271;Reactome: R-HSA-168276;Reactome: R-HSA-5619107;Reactome: R-HSA-4615885;Reactome: R-HSA-159230;Reactome: R-HSA-191859;Reactome: R-HSA-3371453;Reactome: R-HSA-2500257;Reactome: R-HSA-3232142;Reactome: R-HSA-4551638;Reactome: R-HSA-9610379;Reactome: R-HSA-3108214;Reactome: R-HSA-2467813;Reactome: R-HSA-159231;Reactome: R-HSA-1169408;Reactome: R-HSA-9648025;Reactome: R-HSA-5663220;Reactome: R-HSA-159227;Reactome: R-HSA-168333;Reactome: R-HSA-3301854;Reactome: R-HSA-68877;Reactome: R-HSA-180746;Reactome: R-HSA-5578749;Reactome: R-HSA-180910;Reactome: R-HSA-170822;Reactome: R-HSA-6784531;Reactome: R-HSA-4085377;Reactome: R-HSA-165054;Reactome: R-HSA-4570464;Reactome: R-HSA-9609690;Reactome: R-HSA-168325;Reactome: R-HSA-159236;Reactome: R-HSA-141444	"Transport of Ribonucleoproteins into the Host Nucleus";"NS1 Mediated Effects on Host Pathways";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"SUMOylation of DNA replication proteins";"Transport of the SLBP Dependant Mature mRNA";"snRNP Assembly";"Regulation of HSF1-mediated heat shock response";"Resolution of Sister Chromatid Cohesion";"SUMOylation of ubiquitinylation proteins";"SUMOylation of chromatin organization proteins";"HCMV Late Events";"SUMOylation of DNA damage response and repair proteins";"Separation of Sister Chromatids";"Transport of Mature mRNA Derived from an Intronless Transcript";"ISG15 antiviral mechanism";"EML4 and NUDC in mitotic spindle formation";"RHO GTPases Activate Formins";"Transport of the SLBP independent Mature mRNA";"NEP/NS2 Interacts with the Cellular Export Machinery";"Nuclear Pore Complex (NPC) Disassembly";"Mitotic Prometaphase";"Nuclear import of Rev protein";"Transcriptional regulation by small RNAs";"Vpr-mediated nuclear import of PICs";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"tRNA processing in the nucleus";"SUMOylation of SUMOylation proteins";"Rev-mediated nuclear export of HIV RNA";"SUMOylation of RNA binding proteins";"HCMV Early Events";"Viral Messenger RNA Synthesis";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"
XP_046432124.1	1	Reactome: R-HSA-5689880	"Ub-specific processing proteases"
XP_046424076.1	11	Reactome: R-HSA-3371497;Reactome: R-HSA-380270;Reactome: R-HSA-8854518;Reactome: R-HSA-6807878;Reactome: R-HSA-5620912;Reactome: R-HSA-380320;Reactome: R-HSA-2565942;Reactome: R-HSA-6811436;Reactome: R-HSA-380259;Reactome: R-HSA-2132295;Reactome: R-HSA-380284	"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Recruitment of mitotic centrosome proteins and complexes";"AURKA Activation by TPX2";"COPI-mediated anterograde transport";"Anchoring of the basal body to the plasma membrane";"Recruitment of NuMA to mitotic centrosomes";"Regulation of PLK1 Activity at G2/M Transition";"COPI-independent Golgi-to-ER retrograde traffic";"Loss of Nlp from mitotic centrosomes";"MHC class II antigen presentation";"Loss of proteins required for interphase microtubule organization from the centrosome"
XP_046422325.1	3	MetaCyc: PWY-7999;KEGG: 00130+1.17.4.4;Reactome: R-HSA-6806664	"Vitamin K-epoxide cycle";"Ubiquinone and other terpenoid-quinone biosynthesis";"Metabolism of vitamin K"
XP_046421031.1	6	MetaCyc: PWY-7782;MetaCyc: PWY-5884;KEGG: 00073+1.2.1.84;MetaCyc: PWY-7656;MetaCyc: PWY-6733;Reactome: R-HSA-9640463	"Plasmalogen biosynthesis";"Wax esters biosynthesis I";"Cutin, suberine and wax biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Sporopollenin precursors biosynthesis";"Wax biosynthesis"
XP_046436581.1	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046410734.1	4	Reactome: R-HSA-5576893;Reactome: R-HSA-5576892;Reactome: R-HSA-419037;Reactome: R-HSA-112308	"Phase 2 - plateau phase";"Phase 0 - rapid depolarisation";"NCAM1 interactions";"Presynaptic depolarization and calcium channel opening"
XP_046427817.1	4	Reactome: R-HSA-611105;Reactome: R-HSA-6799198;Reactome: R-HSA-389661;Reactome: R-HSA-77289	"Respiratory electron transport";"Complex I biogenesis";"Glyoxylate metabolism and glycine degradation";"Mitochondrial Fatty Acid Beta-Oxidation"
XP_046416443.1	5	Reactome: R-HSA-5693565;Reactome: R-HSA-5693607;Reactome: R-HSA-5689901;Reactome: R-HSA-5693571;Reactome: R-HSA-69473	"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Processing of DNA double-strand break ends";"Metalloprotease DUBs";"Nonhomologous End-Joining (NHEJ)";"G2/M DNA damage checkpoint"
XP_046429275.1	1	Reactome: R-HSA-8856828	"Clathrin-mediated endocytosis"
XP_046417353.1	8	Reactome: R-HSA-1445148;Reactome: R-HSA-380972;Reactome: R-HSA-2151209;Reactome: R-HSA-9619483;Reactome: R-HSA-1632852;Reactome: R-HSA-9613354;Reactome: R-HSA-5628897;Reactome: R-HSA-6804756	"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Energy dependent regulation of mTOR by LKB1-AMPK";"Activation of PPARGC1A (PGC-1alpha) by phosphorylation";"Activation of AMPK downstream of NMDARs";"Macroautophagy";"Lipophagy";"TP53 Regulates Metabolic Genes";"Regulation of TP53 Activity through Phosphorylation"
XP_046417209.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_046417657.1	5	MetaCyc: PWY-7279;MetaCyc: PWY-7082;MetaCyc: PWY-6692;KEGG: 00190+7.1.1.8;MetaCyc: PWY-3781	"Aerobic respiration II (cytochrome c) (yeast)";"Ammonia oxidation IV (autotrophic ammonia oxidizers)";"Fe(II) oxidation";"Oxidative phosphorylation";"Aerobic respiration I (cytochrome c)"
XP_046412851.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046420829.1	1	Reactome: R-HSA-2022377	"Metabolism of Angiotensinogen to Angiotensins"
XP_046424386.1	1	Reactome: R-HSA-9037629	"Lewis blood group biosynthesis"
XP_046428538.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_046422718.1	2	Reactome: R-HSA-1663150;Reactome: R-HSA-1660662	"The activation of arylsulfatases";"Glycosphingolipid metabolism"
XP_046424933.1	1	Reactome: R-HSA-432720	"Lysosome Vesicle Biogenesis"
XP_046413546.1	1	Reactome: R-HSA-5620912	"Anchoring of the basal body to the plasma membrane"
XP_046427979.1	14	Reactome: R-HSA-5687128;Reactome: R-HSA-9022692;Reactome: R-HSA-203927;Reactome: R-HSA-426496;Reactome: R-HSA-9029569;Reactome: R-HSA-426486;Reactome: R-HSA-8934593;Reactome: R-HSA-9018519;Reactome: R-HSA-8948700;Reactome: R-HSA-5628897;Reactome: R-HSA-4086398;Reactome: R-HSA-8986944;Reactome: R-HSA-8943723;Reactome: R-HSA-1912408	"MAPK6/MAPK4 signaling";"Regulation of MECP2 expression and activity";"MicroRNA (miRNA) biogenesis";"Post-transcriptional silencing by small RNAs";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Small interfering RNA (siRNA) biogenesis";"Regulation of RUNX1 Expression and Activity";"Estrogen-dependent gene expression";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"TP53 Regulates Metabolic Genes";"Ca2+ pathway";"Transcriptional Regulation by MECP2";"Regulation of PTEN mRNA translation";"Pre-NOTCH Transcription and Translation"
XP_046414794.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_046430965.1	1	Reactome: R-HSA-8850843	"Phosphate bond hydrolysis by NTPDase proteins"
XP_046425357.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_046421970.1	2	Reactome: R-HSA-1296052;Reactome: R-HSA-418457	"Ca2+ activated K+ channels";"cGMP effects"
XP_046418305.1	1	Reactome: R-HSA-211945	"Phase I - Functionalization of compounds"
XP_046425791.1	2	Reactome: R-HSA-983168;Reactome: R-HSA-110320	"Antigen processing: Ubiquitination & Proteasome degradation";"Translesion Synthesis by POLH"
XP_046424380.1	2	Reactome: R-HSA-418594;Reactome: R-HSA-6814122	"G alpha (i) signalling events";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"
XP_046424026.1	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
XP_046412690.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046413656.1	3	Reactome: R-HSA-72165;Reactome: R-HSA-430039;Reactome: R-HSA-72163	"mRNA Splicing - Minor Pathway";"mRNA decay by 5' to 3' exoribonuclease";"mRNA Splicing - Major Pathway"
XP_046414796.1	3	Reactome: R-HSA-9033241;Reactome: R-HSA-8866654;Reactome: R-HSA-9603798	"Peroxisomal protein import";"E3 ubiquitin ligases ubiquitinate target proteins";"Class I peroxisomal membrane protein import"
XP_046424737.1	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
XP_046415480.1	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
XP_046415624.1	1	MetaCyc: PWY-6308	"L-cysteine biosynthesis II (tRNA-dependent)"
XP_046428767.1	7	KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1	"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Thermogenesis";"Human cytomegalovirus infection";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Relaxin signaling pathway"
XP_046419780.1	1	Reactome: R-HSA-390522	"Striated Muscle Contraction"
XP_046432979.1	1	Reactome: R-HSA-70221	"Glycogen breakdown (glycogenolysis)"
XP_046410973.1	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
XP_046423583.1	2	Reactome: R-HSA-6793080;Reactome: R-HSA-2151201	"rRNA modification in the mitochondrion";"Transcriptional activation of mitochondrial biogenesis"
XP_046416353.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046421927.1	3	KEGG: 00790+4.2.1.96;MetaCyc: PWY-8099;MetaCyc: PWY-7158	"Folate biosynthesis";"Tetrahydropteridine recycling";"L-phenylalanine degradation V"
XP_046412964.1	13	Reactome: R-HSA-3928662;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04714+2.7.11.1;Reactome: R-HSA-3928663;KEGG: 04150+2.7.11.1;Reactome: R-HSA-416482;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;Reactome: R-HSA-5627117;Reactome: R-HSA-416572;KEGG: 05163+2.7.11.1;Reactome: R-HSA-4420097	"EPHB-mediated forward signaling";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Thermogenesis";"EPHA-mediated growth cone collapse";"mTOR signaling pathway";"G alpha (12/13) signalling events";"PI3K-Akt signaling pathway";"Relaxin signaling pathway";"RHO GTPases Activate ROCKs";"Sema4D induced cell migration and growth-cone collapse";"Human cytomegalovirus infection";"VEGFA-VEGFR2 Pathway"
XP_046422380.1	2	Reactome: R-HSA-3299685;KEGG: 00480+1.11.1.15	"Detoxification of Reactive Oxygen Species";"Glutathione metabolism"
XP_046432080.1	7	KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1	"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Human cytomegalovirus infection";"Thermogenesis";"Relaxin signaling pathway";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection"
XP_046433833.1	1	Reactome: R-HSA-1474228	"Degradation of the extracellular matrix"
XP_046421789.1	3	Reactome: R-HSA-73856;Reactome: R-HSA-72187;Reactome: R-HSA-159236	"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing";"Transport of Mature mRNA derived from an Intron-Containing Transcript"
XP_046430265.1	2	Reactome: R-HSA-389661;Reactome: R-HSA-9033241	"Glyoxylate metabolism and glycine degradation";"Peroxisomal protein import"
XP_046415782.1	2	Reactome: R-HSA-8866907;Reactome: R-HSA-8866904	"Activation of the TFAP2 (AP-2) family of transcription factors";"Negative regulation of activity of TFAP2 (AP-2) family transcription factors"
XP_046434861.1	1	Reactome: R-HSA-203615	"eNOS activation"
XP_046417465.1	2	Reactome: R-HSA-5693568;Reactome: R-HSA-6783310	"Resolution of D-loop Structures through Holliday Junction Intermediates";"Fanconi Anemia Pathway"
XP_046418914.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_046412320.1	4	MetaCyc: PWY-6483;KEGG: 00600+3.5.1.23;Reactome: R-HSA-1660662;MetaCyc: PWY-7119	"Ceramide degradation (generic)";"Sphingolipid metabolism";"Glycosphingolipid metabolism";"Ceramide and sphingolipid recycling and degradation (yeast)"
XP_046425128.1	1	Reactome: R-HSA-975957	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
XP_046420205.1	3	Reactome: R-HSA-111367;Reactome: R-HSA-77588;Reactome: R-HSA-73856	"SLBP independent Processing of Histone Pre-mRNAs";"SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs";"RNA Polymerase II Transcription Termination"
XP_046412386.1	3	KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16	"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
XP_046422205.1	2	Reactome: R-HSA-3214858;Reactome: R-HSA-8939243	"RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"
XP_046422728.1	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
XP_046410245.1	1	Reactome: R-HSA-975957	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
XP_046429185.1	6	KEGG: 00512+2.4.1.122;Reactome: R-HSA-5083632;Reactome: R-HSA-913709;MetaCyc: PWY-7290;MetaCyc: PWY-7433;KEGG: 00514+2.4.1.122	"Mucin type O-glycan biosynthesis";"Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS)";"O-linked glycosylation of mucins";"Escherichia coli serotype O86 O-antigen biosynthesis";"Mucin core 1 and core 2 O-glycosylation";"Other types of O-glycan biosynthesis"
XP_046424914.1	3	Reactome: R-HSA-6798695;Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Neutrophil degranulation";"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_046420617.1	1	Reactome: R-HSA-400253	"Circadian Clock"
XP_046433639.1	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_046413898.1	5	Reactome: R-HSA-159231;Reactome: R-HSA-72163;Reactome: R-HSA-72187;Reactome: R-HSA-73856;Reactome: R-HSA-77595	"Transport of Mature mRNA Derived from an Intronless Transcript";"mRNA Splicing - Major Pathway";"mRNA 3'-end processing";"RNA Polymerase II Transcription Termination";"Processing of Intronless Pre-mRNAs"
XP_046421732.1	2	Reactome: R-HSA-1221632;Reactome: R-HSA-5601884	"Meiotic synapsis";"PIWI-interacting RNA (piRNA) biogenesis"
XP_046430209.1	2	Reactome: R-HSA-2682334;Reactome: R-HSA-3928665	"EPH-Ephrin signaling";"EPH-ephrin mediated repulsion of cells"
XP_046422249.1	3	Reactome: R-HSA-749476;Reactome: R-HSA-76066;Reactome: R-HSA-76061	"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Transcription Initiation From Type 1 Promoter"
XP_046423139.1	1	Reactome: R-HSA-6785807	"Interleukin-4 and Interleukin-13 signaling"
XP_046410793.1	4	Reactome: R-HSA-2408522;KEGG: 00450+6.1.1.10;KEGG: 00970+6.1.1.10;Reactome: R-HSA-379716	"Selenoamino acid metabolism";"Selenocompound metabolism";"Aminoacyl-tRNA biosynthesis";"Cytosolic tRNA aminoacylation"
XP_046434484.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046434689.1	3	KEGG: 00230+3.5.4.6;Reactome: R-HSA-74217;MetaCyc: PWY-6596	"Purine metabolism";"Purine salvage";"Adenosine nucleotides degradation I"
XP_046428086.1	4	Reactome: R-HSA-5578775;Reactome: R-HSA-936837;Reactome: R-HSA-1912420;Reactome: R-HSA-418359	"Ion homeostasis";"Ion transport by P-type ATPases";"Pre-NOTCH Processing in Golgi";"Reduction of cytosolic Ca++ levels"
XP_046416745.1	2	Reactome: R-HSA-3214841;Reactome: R-HSA-8936459	"PKMTs methylate histone lysines";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"
XP_046419920.1	8	Reactome: R-HSA-5083629;Reactome: R-HSA-5173105;MetaCyc: PWY-7922;KEGG: 00514+2.4.1.109;MetaCyc: PWY-7921;Reactome: R-HSA-5083633;KEGG: 00515+2.4.1.109;MetaCyc: PWY-7979	"Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2";"O-linked glycosylation";"Protein O-mannosylation II (mammals, core M1 and core M2)";"Other types of O-glycan biosynthesis";"Protein O-mannosylation I (yeast)";"Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1";"Mannose type O-glycan biosynthesis";"Protein O-mannosylation III (mammals, core M3)"
XP_046423325.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046424831.1	3	KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway"
XP_046419115.1	1	Reactome: R-HSA-382556	"ABC-family proteins mediated transport"
XP_046425403.1	2	Reactome: R-HSA-162588;Reactome: R-HSA-917729	"Budding and maturation of HIV virion";"Endosomal Sorting Complex Required For Transport (ESCRT)"
XP_046420933.1	3	Reactome: R-HSA-212436;Reactome: R-HSA-1989781;Reactome: R-HSA-381340	"Generic Transcription Pathway";"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation"
XP_046434053.1	1	Reactome: R-HSA-1296061	"HCN channels"
XP_046425780.1	2	MetaCyc: PWY-6854;Reactome: R-HSA-3299685	"Ethylene biosynthesis III (microbes)";"Detoxification of Reactive Oxygen Species"
XP_046435528.1	2	Reactome: R-HSA-400253;Reactome: R-HSA-2151201	"Circadian Clock";"Transcriptional activation of mitochondrial biogenesis"
XP_046432477.1	17	MetaCyc: PWY-7187;MetaCyc: PWY-7184;MetaCyc: PWY-7210;MetaCyc: PWY-7221;MetaCyc: PWY-7222;MetaCyc: PWY-6545;KEGG: 00230+2.7.4.6;MetaCyc: PWY-7176;KEGG: 00983+2.7.4.6;MetaCyc: PWY-7220;MetaCyc: PWY-7205;MetaCyc: PWY-7197;MetaCyc: PWY-7224;MetaCyc: PWY-7227;MetaCyc: PWY-7226;KEGG: 00240+2.7.4.6;MetaCyc: PWY-7198	"Pyrimidine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Guanosine ribonucleotides de novo biosynthesis";"Guanosine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Purine metabolism";"UTP and CTP de novo biosynthesis";"Drug metabolism - other enzymes";"Adenosine deoxyribonucleotides de novo biosynthesis II";"CMP phosphorylation";"Pyrimidine deoxyribonucleotide phosphorylation";"Purine deoxyribonucleosides salvage";"Adenosine deoxyribonucleotides de novo biosynthesis";"Guanosine deoxyribonucleotides de novo biosynthesis I";"Pyrimidine metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV"
XP_046420896.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_046435090.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_046419229.1	9	Reactome: R-HSA-9620244;Reactome: R-HSA-5673001;Reactome: R-HSA-3928662;Reactome: R-HSA-9617324;Reactome: R-HSA-438066;Reactome: R-HSA-8849932;Reactome: R-HSA-6794361;Reactome: R-HSA-442982;Reactome: R-HSA-9609736	"Long-term potentiation";"RAF/MAP kinase cascade";"EPHB-mediated forward signaling";"Negative regulation of NMDA receptor-mediated neuronal transmission";"Unblocking of NMDA receptors, glutamate binding and activation";"Synaptic adhesion-like molecules";"Neurexins and neuroligins";"Ras activation upon Ca2+ influx through NMDA receptor";"Assembly and cell surface presentation of NMDA receptors"
XP_046427635.1	1	Reactome: R-HSA-6807878	"COPI-mediated anterograde transport"
XP_046421955.1	2	Reactome: R-HSA-1296052;Reactome: R-HSA-418457	"Ca2+ activated K+ channels";"cGMP effects"
XP_046419581.1	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
XP_046411013.1	5	Reactome: R-HSA-8854214;Reactome: R-HSA-165181;Reactome: R-HSA-5628897;Reactome: R-HSA-380972;Reactome: R-HSA-1632852	"TBC/RABGAPs";"Inhibition of TSC complex formation by PKB";"TP53 Regulates Metabolic Genes";"Energy dependent regulation of mTOR by LKB1-AMPK";"Macroautophagy"
XP_046435929.1	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286	"Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation"
XP_046413235.1	1	Reactome: R-HSA-70221	"Glycogen breakdown (glycogenolysis)"
XP_046410957.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046423527.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046435742.1	7	Reactome: R-HSA-390450;Reactome: R-HSA-390471;Reactome: R-HSA-389960;Reactome: R-HSA-389957;Reactome: R-HSA-5620922;Reactome: R-HSA-8950505;Reactome: R-HSA-6814122	"Folding of actin by CCT/TriC";"Association of TriC/CCT with target proteins during biosynthesis";"Formation of tubulin folding intermediates by CCT/TriC";"Prefoldin mediated transfer of substrate to CCT/TriC";"BBSome-mediated cargo-targeting to cilium";"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"
XP_046426516.1	1	Reactome: R-HSA-72203	"Processing of Capped Intron-Containing Pre-mRNA"
XP_046421231.1	13	MetaCyc: PWY-7384;Reactome: R-HSA-71403;MetaCyc: PWY-5690;KEGG: 00020+6.2.1.5;KEGG: 00720+6.2.1.5;MetaCyc: PWY-5537;MetaCyc: PWY-5392;KEGG: 00660+6.2.1.5;KEGG: 00640+6.2.1.5;MetaCyc: PWY-5913;MetaCyc: PWY-6728;MetaCyc: PWY-6969;MetaCyc: PWY-5538	"Anaerobic energy metabolism (invertebrates, mitochondrial)";"Citric acid cycle (TCA cycle)";"TCA cycle II (plants and fungi)";"Citrate cycle (TCA cycle)";"Carbon fixation pathways in prokaryotes";"Pyruvate fermentation to acetate V";"Reductive TCA cycle II";"C5-Branched dibasic acid metabolism";"Propanoate metabolism";"Partial TCA cycle (obligate autotrophs)";"Methylaspartate cycle";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Pyruvate fermentation to acetate VI"
XP_046429271.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046431909.1	3	KEGG: 00130+4.1.1.90;Reactome: R-HSA-159740;MetaCyc: PWY-7999	"Ubiquinone and other terpenoid-quinone biosynthesis";"Gamma-carboxylation of protein precursors";"Vitamin K-epoxide cycle"
XP_046413495.1	11	Reactome: R-HSA-163359;Reactome: R-HSA-164378;Reactome: R-HSA-418555;Reactome: R-HSA-170660;Reactome: R-HSA-418597;Reactome: R-HSA-418594;Reactome: R-HSA-432040;Reactome: R-HSA-5610787;Reactome: R-HSA-163615;Reactome: R-HSA-170670;KEGG: 00230+4.6.1.1	"Glucagon signaling in metabolic regulation";"PKA activation in glucagon signalling";"G alpha (s) signalling events";"Adenylate cyclase activating pathway";"G alpha (z) signalling events";"G alpha (i) signalling events";"Vasopressin regulates renal water homeostasis via Aquaporins";"Hedgehog 'off' state";"PKA activation";"Adenylate cyclase inhibitory pathway";"Purine metabolism"
XP_046417803.1	5	Reactome: R-HSA-201722;Reactome: R-HSA-8939243;Reactome: R-HSA-1266695;Reactome: R-HSA-3214858;Reactome: R-HSA-3247509	"Formation of the beta-catenin:TCF transactivating complex";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"Interleukin-7 signaling";"RMTs methylate histone arginines";"Chromatin modifying enzymes"
XP_046421858.1	1	Reactome: R-HSA-8873719	"RAB geranylgeranylation"
XP_046417169.1	2	Reactome: R-HSA-1660662;Reactome: R-HSA-390471	"Glycosphingolipid metabolism";"Association of TriC/CCT with target proteins during biosynthesis"
XP_046435250.1	5	KEGG: 00052+2.7.1.6;KEGG: 00520+2.7.1.6;MetaCyc: PWY-6527;MetaCyc: PWY-6317;MetaCyc: PWY-3821	"Galactose metabolism";"Amino sugar and nucleotide sugar metabolism";"Stachyose degradation";"D-galactose degradation I (Leloir pathway)";"D-galactose detoxification"
XP_046420985.1	1	Reactome: R-HSA-4551638	"SUMOylation of chromatin organization proteins"
XP_046410021.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_046412009.1	19	KEGG: 00720+1.1.1.37;MetaCyc: PWY-6969;KEGG: 00710+1.1.1.37;MetaCyc: PWY-6728;KEGG: 00680+1.1.1.37;KEGG: 00620+1.1.1.37;MetaCyc: PWY-5392;MetaCyc: PWY-561;KEGG: 00270+1.1.1.37;MetaCyc: PWY-8086;MetaCyc: PWY-7115;MetaCyc: PWY-7383;KEGG: 00630+1.1.1.37;MetaCyc: PWY-5913;KEGG: 00020+1.1.1.37;MetaCyc: PWY-5690;Reactome: R-HSA-71403;MetaCyc: PWY-1622;Reactome: R-HSA-70263	"Carbon fixation pathways in prokaryotes";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Carbon fixation in photosynthetic organisms";"Methylaspartate cycle";"Methane metabolism";"Pyruvate metabolism";"Reductive TCA cycle II";"Superpathway of glyoxylate cycle and fatty acid degradation";"Cysteine and methionine metabolism";"(S)-lactate fermentation to propanoate, acetate and hydrogen";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"Anaerobic energy metabolism (invertebrates, cytosol)";"Glyoxylate and dicarboxylate metabolism";"Partial TCA cycle (obligate autotrophs)";"Citrate cycle (TCA cycle)";"TCA cycle II (plants and fungi)";"Citric acid cycle (TCA cycle)";"Formaldehyde assimilation I (serine pathway)";"Gluconeogenesis"
XP_046426743.1	3	Reactome: R-HSA-8951664;Reactome: R-HSA-349425;MetaCyc: PWY-7511	"Neddylation";"Autodegradation of the E3 ubiquitin ligase COP1";"Protein ubiquitination"
XP_046421968.1	2	Reactome: R-HSA-418457;Reactome: R-HSA-1296052	"cGMP effects";"Ca2+ activated K+ channels"
XP_046416342.1	1	Reactome: R-HSA-1483255	"PI Metabolism"
XP_046433382.1	3	Reactome: R-HSA-416482;Reactome: R-HSA-194840;Reactome: R-HSA-193648	"G alpha (12/13) signalling events";"Rho GTPase cycle";"NRAGE signals death through JNK"
XP_046426013.1	20	MetaCyc: PWY-7858;MetaCyc: PWY-7291;MetaCyc: PWY-6920;KEGG: 00071+1.3.3.6;MetaCyc: PWY-7338;MetaCyc: PWY-735;KEGG: 00640+1.3.3.6;KEGG: 00592+1.3.3.6;MetaCyc: PWY-6837;KEGG: 00410+1.3.3.6;Reactome: R-HSA-9033241;MetaCyc: PWY-5136;MetaCyc: PWY-7854;MetaCyc: PWY-7007;MetaCyc: PWY-7606;MetaCyc: PWY-7726;MetaCyc: PWY-7288;MetaCyc: PWY-7340;MetaCyc: PWY-7574;MetaCyc: PWY-7337	"(5Z)-dodecenoate biosynthesis II";"Oleate beta-oxidation (isomerase-dependent, yeast)";"6-gingerol analog biosynthesis (engineered)";"Fatty acid degradation";"10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast)";"Jasmonic acid biosynthesis";"Propanoate metabolism";"alpha-Linolenic acid metabolism";"Fatty acid beta-oxidation V (unsaturated, odd number, di-isomerase-dependent)";"beta-Alanine metabolism";"Peroxisomal protein import";"Fatty acid beta-oxidation II (plant peroxisome)";"Crotonyl-coa/ethylmalonyl-coa/hydroxybutyryl-coa cycle (engineered)";"Methyl ketone biosynthesis (engineered)";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"Fatty acid beta-oxidation VII (yeast peroxisome)";"9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast)";"Propanoyl-coa degradation II";"10-cis-heptadecenoyl-CoA degradation (yeast)"
XP_046425413.1	2	Reactome: R-HSA-8856828;Reactome: R-HSA-8856825	"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis"
XP_046433241.1	1	Reactome: R-HSA-3295583	"TRP channels"
XP_046416513.1	3	Reactome: R-HSA-76066;Reactome: R-HSA-76061;Reactome: R-HSA-749476	"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Abortive And Retractive Initiation"
XP_046417213.1	1	Reactome: R-HSA-5689880	"Ub-specific processing proteases"
XP_046417809.1	5	Reactome: R-HSA-3247509;Reactome: R-HSA-3214858;Reactome: R-HSA-1266695;Reactome: R-HSA-8939243;Reactome: R-HSA-201722	"Chromatin modifying enzymes";"RMTs methylate histone arginines";"Interleukin-7 signaling";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"Formation of the beta-catenin:TCF transactivating complex"
XP_046417814.1	4	Reactome: R-HSA-1170546;Reactome: R-HSA-983231;Reactome: R-HSA-2586552;Reactome: R-HSA-982772	"Prolactin receptor signaling";"Factors involved in megakaryocyte development and platelet production";"Signaling by Leptin";"Growth hormone receptor signaling"
XP_046429917.1	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
XP_046419896.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046423026.1	7	Reactome: R-HSA-373753;Reactome: R-HSA-5673001;Reactome: R-HSA-6807878;Reactome: R-HSA-375165;Reactome: R-HSA-264870;Reactome: R-HSA-445095;Reactome: R-HSA-6798695	"Nephrin family interactions";"RAF/MAP kinase cascade";"COPI-mediated anterograde transport";"NCAM signaling for neurite out-growth";"Caspase-mediated cleavage of cytoskeletal proteins";"Interaction between L1 and Ankyrins";"Neutrophil degranulation"
XP_046416765.1	2	Reactome: R-HSA-381340;Reactome: R-HSA-1989781	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression"
XP_046426123.1	1	Reactome: R-HSA-5658442	"Regulation of RAS by GAPs"
XP_046412522.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_046422099.1	1	Reactome: R-HSA-6804754	"Regulation of TP53 Expression"
XP_046409304.1	1	Reactome: R-HSA-6811434	"COPI-dependent Golgi-to-ER retrograde traffic"
XP_046421922.1	12	KEGG: 00590+3.1.1.4;KEGG: 00592+3.1.1.4;MetaCyc: PWY-7783;MetaCyc: PWY-8051;KEGG: 00565+3.1.1.4;MetaCyc: PWY-6803;KEGG: 00591+3.1.1.4;KEGG: 00564+3.1.1.4;MetaCyc: PWY-7417;MetaCyc: PWY-7409;MetaCyc: PWY-8053;MetaCyc: PWY-7416	"Arachidonic acid metabolism";"alpha-Linolenic acid metabolism";"Plasmalogen degradation";"Anandamide biosynthesis I";"Ether lipid metabolism";"Phosphatidylcholine acyl editing";"Linoleic acid metabolism";"Glycerophospholipid metabolism";"Phospholipid remodeling (phosphatidate, yeast)";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Anandamide biosynthesis II";"Phospholipid remodeling (phosphatidylcholine, yeast)"
XP_046422857.1	1	Reactome: R-HSA-426048	"Arachidonate production from DAG"
XP_046413628.1	2	Reactome: R-HSA-2029482;Reactome: R-HSA-5663213	"Regulation of actin dynamics for phagocytic cup formation";"RHO GTPases Activate WASPs and WAVEs"
XP_046419404.1	2	Reactome: R-HSA-2514859;KEGG: 00900+2.5.1.58	"Inactivation, recovery and regulation of the phototransduction cascade";"Terpenoid backbone biosynthesis"
XP_046409752.1	8	Reactome: R-HSA-69091;Reactome: R-HSA-113501;Reactome: R-HSA-68952;Reactome: R-HSA-174430;Reactome: R-HSA-69183;Reactome: R-HSA-174411;Reactome: R-HSA-68962;Reactome: R-HSA-69166	"Polymerase switching";"Inhibition of replication initiation of damaged DNA by RB1/E2F1";"DNA replication initiation";"Telomere C-strand synthesis initiation";"Processive synthesis on the lagging strand";"Polymerase switching on the C-strand of the telomere";"Activation of the pre-replicative complex";"Removal of the Flap Intermediate"
XP_046433454.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_046432727.1	9	Reactome: R-HSA-69473;Reactome: R-HSA-6804756;Reactome: R-HSA-5685938;Reactome: R-HSA-5693616;Reactome: R-HSA-5693554;Reactome: R-HSA-5693568;Reactome: R-HSA-5693579;Reactome: R-HSA-5693607;Reactome: R-HSA-5685942	"G2/M DNA damage checkpoint";"Regulation of TP53 Activity through Phosphorylation";"HDR through Single Strand Annealing (SSA)";"Presynaptic phase of homologous DNA pairing and strand exchange";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Resolution of D-loop Structures through Holliday Junction Intermediates";"Homologous DNA Pairing and Strand Exchange";"Processing of DNA double-strand break ends";"HDR through Homologous Recombination (HRR)"
XP_046416009.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_046413206.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046418711.1	3	Reactome: R-HSA-4420097;KEGG: 04660+2.7.10.2;Reactome: R-HSA-391160	"VEGFA-VEGFR2 Pathway";"T cell receptor signaling pathway";"Signal regulatory protein family interactions"
XP_046428740.1	1	Reactome: R-HSA-5368286	"Mitochondrial translation initiation"
XP_046410742.1	4	Reactome: R-HSA-5576893;Reactome: R-HSA-5576892;Reactome: R-HSA-419037;Reactome: R-HSA-112308	"Phase 2 - plateau phase";"Phase 0 - rapid depolarisation";"NCAM1 interactions";"Presynaptic depolarization and calcium channel opening"
XP_046432833.1	3	Reactome: R-HSA-5576893;Reactome: R-HSA-5576890;Reactome: R-HSA-1296072	"Phase 2 - plateau phase";"Phase 3 - rapid repolarisation";"Voltage gated Potassium channels"
XP_046430692.1	16	Reactome: R-HSA-72706;Reactome: R-HSA-2408557;Reactome: R-HSA-9633012;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-975956;Reactome: R-HSA-72702;Reactome: R-HSA-6791226;Reactome: R-HSA-72695;Reactome: R-HSA-1799339;Reactome: R-HSA-72689;Reactome: R-HSA-192823;Reactome: R-HSA-156902;Reactome: R-HSA-72649;Reactome: R-HSA-72764;Reactome: R-HSA-975957	"GTP hydrolysis and joining of the 60S ribosomal subunit";"Selenocysteine synthesis";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Ribosomal scanning and start codon recognition";"Major pathway of rRNA processing in the nucleolus and cytosol";"Formation of the ternary complex, and subsequently, the 43S complex";"SRP-dependent cotranslational protein targeting to membrane";"Formation of a pool of free 40S subunits";"Viral mRNA Translation";"Peptide chain elongation";"Translation initiation complex formation";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
XP_046431033.1	2	Reactome: R-HSA-5689603;Reactome: R-HSA-5696394	"UCH proteinases";"DNA Damage Recognition in GG-NER"
XP_046417051.1	2	Reactome: R-HSA-983231;Reactome: R-HSA-383280	"Factors involved in megakaryocyte development and platelet production";"Nuclear Receptor transcription pathway"
XP_046421228.1	1	Reactome: R-HSA-6807878	"COPI-mediated anterograde transport"
XP_046415492.1	2	Reactome: R-HSA-5610787;Reactome: R-HSA-5620924	"Hedgehog 'off' state";"Intraflagellar transport"
XP_046427732.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_046428768.1	7	KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1	"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Relaxin signaling pathway";"Thermogenesis";"Human cytomegalovirus infection";"mTOR signaling pathway";"PI3K-Akt signaling pathway"
XP_046409731.1	2	Reactome: R-HSA-983231;Reactome: R-HSA-383280	"Factors involved in megakaryocyte development and platelet production";"Nuclear Receptor transcription pathway"
XP_046423345.1	2	Reactome: R-HSA-180024;KEGG: 00230+3.1.4.53	"DARPP-32 events";"Purine metabolism"
XP_046425144.1	1	Reactome: R-HSA-1221632	"Meiotic synapsis"
XP_046417174.1	2	Reactome: R-HSA-1660662;Reactome: R-HSA-390471	"Glycosphingolipid metabolism";"Association of TriC/CCT with target proteins during biosynthesis"
XP_046433249.1	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
XP_046424376.1	2	Reactome: R-HSA-418594;Reactome: R-HSA-6814122	"G alpha (i) signalling events";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"
XP_046410246.1	1	Reactome: R-HSA-975957	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
XP_046420189.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_046433680.1	6	Reactome: R-HSA-5617472;Reactome: R-HSA-3769402;Reactome: R-HSA-8951664;Reactome: R-HSA-8936459;Reactome: R-HSA-3214841;Reactome: R-HSA-201722	"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Deactivation of the beta-catenin transactivating complex";"Neddylation";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"PKMTs methylate histone lysines";"Formation of the beta-catenin:TCF transactivating complex"
XP_046411636.1	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
XP_046424839.1	1	KEGG: 00450+1.8.1.9	"Selenocompound metabolism"
XP_046421612.1	2	Reactome: R-HSA-446193;Reactome: R-HSA-4570571	"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"Defective RFT1 causes RFT1-CDG (CDG-1n)"
XP_046421965.1	2	Reactome: R-HSA-1296052;Reactome: R-HSA-418457	"Ca2+ activated K+ channels";"cGMP effects"
XP_046431236.1	13	Reactome: R-HSA-975957;Reactome: R-HSA-6791226;Reactome: R-HSA-975956;Reactome: R-HSA-156902;Reactome: R-HSA-72764;Reactome: R-HSA-9633012;Reactome: R-HSA-72689;Reactome: R-HSA-192823;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-2408557;Reactome: R-HSA-72706;Reactome: R-HSA-1799339	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Peptide chain elongation";"Eukaryotic Translation Termination";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Formation of a pool of free 40S subunits";"Viral mRNA Translation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Selenocysteine synthesis";"GTP hydrolysis and joining of the 60S ribosomal subunit";"SRP-dependent cotranslational protein targeting to membrane"
XP_046424599.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046432744.1	5	Reactome: R-HSA-5673001;Reactome: R-HSA-6811558;Reactome: R-HSA-1257604;Reactome: R-HSA-109704;Reactome: R-HSA-2219530	"RAF/MAP kinase cascade";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"PIP3 activates AKT signaling";"PI3K Cascade";"Constitutive Signaling by Aberrant PI3K in Cancer"
XP_046424340.1	1	Reactome: R-HSA-499943	"Interconversion of nucleotide di- and triphosphates"
XP_046434652.1	1	Reactome: R-HSA-209968	"Thyroxine biosynthesis"
XP_046436304.1	4	MetaCyc: PWY-7494;MetaCyc: PWY-3722;KEGG: 00260+1.2.1.8+1.1.99.1;Reactome: R-HSA-6798163	"Choline degradation IV";"Glycine betaine biosynthesis II (Gram-positive bacteria)";"Glycine, serine and threonine metabolism";"Choline catabolism"
XP_046416924.1	14	MetaCyc: PWY-8053;MetaCyc: PWY-7416;MetaCyc: PWY-7409;MetaCyc: PWY-7417;KEGG: 00591+3.1.1.4;Reactome: R-HSA-1482788;MetaCyc: PWY-6803;KEGG: 00565+3.1.1.4;KEGG: 00564+3.1.1.4+3.1.1.5;MetaCyc: PWY-8051;MetaCyc: PWY-7783;KEGG: 00592+3.1.1.4;Reactome: R-HSA-975634;KEGG: 00590+3.1.1.4	"Anandamide biosynthesis II";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Phospholipid remodeling (phosphatidate, yeast)";"Linoleic acid metabolism";"Acyl chain remodelling of PC";"Phosphatidylcholine acyl editing";"Ether lipid metabolism";"Glycerophospholipid metabolism";"Anandamide biosynthesis I";"Plasmalogen degradation";"alpha-Linolenic acid metabolism";"Retinoid metabolism and transport";"Arachidonic acid metabolism"
XP_046413372.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_046432691.1	2	Reactome: R-HSA-5576892;Reactome: R-HSA-445095	"Phase 0 - rapid depolarisation";"Interaction between L1 and Ankyrins"
XP_046425407.1	2	Reactome: R-HSA-8856825;Reactome: R-HSA-8856828	"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis"
XP_046416459.1	31	MetaCyc: PWY-7388;MetaCyc: PWY-5966-1;MetaCyc: PWY-6799;MetaCyc: PWY-4381;Reactome: R-HSA-199220;MetaCyc: PWY-8012;MetaCyc: PWY-8049;MetaCyc: PWYG-321;Reactome: R-HSA-2426168;MetaCyc: PWY-7664;MetaCyc: PWY-5142;MetaCyc: PWY-5367;KEGG: 00780+1.1.1.100+4.2.1.59+2.3.1.41;MetaCyc: PWY-5366;MetaCyc: PWY-5147;MetaCyc: PWY-5989;MetaCyc: PWY-7723;MetaCyc: PWY-7746;MetaCyc: PWY-7858;Reactome: R-HSA-9029558;Reactome: R-HSA-75105;MetaCyc: PWY-6282;KEGG: 00061+1.1.1.100+2.3.1.85+4.2.1.59+2.3.1.39+2.3.1.41+3.1.2.14;MetaCyc: PWY-8047;MetaCyc: PWY-5973;MetaCyc: PWY-5971;Reactome: R-HSA-163765;MetaCyc: PWY-7663;MetaCyc: PWY-6519;MetaCyc: PWY-6113;MetaCyc: PWY-5994	"Octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast)";"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)";"Fatty acid biosynthesis initiation (plant mitochondria)";"Fatty acid biosynthesis initiation (bacteria and plants)";"Vitamin B5 (pantothenate) metabolism";"Mupirocin biosynthesis";"Pederin biosynthesis";"";"Activation of gene expression by SREBF (SREBP)";"Oleate biosynthesis IV (anaerobic)";"Acyl-[acyl-carrier protein] thioesterase pathway";"Petroselinate biosynthesis";"Biotin metabolism";"Palmitoleate biosynthesis II (plants and bacteria)";"Oleate biosynthesis I (plants)";"Stearate biosynthesis II (bacteria and plants)";"Bacterial bioluminescence";"Mycobacterial sulfolipid biosynthesis";"(5Z)-dodecenoate biosynthesis II";"NR1H2 & NR1H3 regulate gene expression linked to lipogenesis";"Fatty acyl-CoA biosynthesis";"Palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate)";"Fatty acid biosynthesis";"Bryostatin biosynthesis";"Cis-vaccenate biosynthesis";"Palmitate biosynthesis II (bacteria and plant cytoplasm)";"ChREBP activates metabolic gene expression";"Gondoate biosynthesis (anaerobic)";"8-amino-7-oxononanoate biosynthesis I";"Superpathway of mycolate biosynthesis";"Palmitate biosynthesis (animals and fungi, cytoplasm)"
XP_046415615.1	14	MetaCyc: PWY-8055;KEGG: 00561+2.3.1.51;KEGG: 00564+2.3.1.51;MetaCyc: PWY-8051;MetaCyc: PWY-6453;MetaCyc: PWY-5667;MetaCyc: PWY-7411;Reactome: R-HSA-1483166;MetaCyc: PWY-7587;MetaCyc: PWY-7589;MetaCyc: PWY-7782;MetaCyc: PWY-8053;MetaCyc: PWY-5981;MetaCyc: PWY-7417	"Palmitoyl ethanolamide biosynthesis";"Glycerolipid metabolism";"Glycerophospholipid metabolism";"Anandamide biosynthesis I";"Stigma estolide biosynthesis";"CDP-diacylglycerol biosynthesis I";"Phosphatidate biosynthesis (yeast)";"Synthesis of PA";"Oleate biosynthesis III (cyanobacteria)";"Palmitoleate biosynthesis III (cyanobacteria)";"Plasmalogen biosynthesis";"Anandamide biosynthesis II";"CDP-diacylglycerol biosynthesis III";"Phospholipid remodeling (phosphatidate, yeast)"
XP_046410133.1	6	KEGG: 00562+3.1.3.66;MetaCyc: PWY-6368;Reactome: R-HSA-1855183;KEGG: 04070+3.1.3.66;Reactome: R-HSA-1660499;Reactome: R-HSA-1660516	"Inositol phosphate metabolism";"3-phosphoinositide degradation";"Synthesis of IP2, IP, and Ins in the cytosol";"Phosphatidylinositol signaling system";"Synthesis of PIPs at the plasma membrane";"Synthesis of PIPs at the early endosome membrane"
XP_046419848.1	2	Reactome: R-HSA-390471;Reactome: R-HSA-1660662	"Association of TriC/CCT with target proteins during biosynthesis";"Glycosphingolipid metabolism"
XP_046435899.1	3	Reactome: R-HSA-8963901;Reactome: R-HSA-6807878;Reactome: R-HSA-445095	"Chylomicron remodeling";"COPI-mediated anterograde transport";"Interaction between L1 and Ankyrins"
XP_046421781.1	1	Reactome: R-HSA-606279	"Deposition of new CENPA-containing nucleosomes at the centromere"
XP_046410066.1	3	Reactome: R-HSA-9033241;Reactome: R-HSA-9603798;Reactome: R-HSA-8866654	"Peroxisomal protein import";"Class I peroxisomal membrane protein import";"E3 ubiquitin ligases ubiquitinate target proteins"
XP_046435774.1	16	Reactome: R-HSA-167152;Reactome: R-HSA-167290;Reactome: R-HSA-167200;Reactome: R-HSA-6796648;Reactome: R-HSA-674695;Reactome: R-HSA-9010553;Reactome: R-HSA-167243;Reactome: R-HSA-112382;Reactome: R-HSA-75955;Reactome: R-HSA-983168;Reactome: R-HSA-1234176;Reactome: R-HSA-167287;Reactome: R-HSA-180585;Reactome: R-HSA-167238;Reactome: R-HSA-167246;Reactome: R-HSA-8951664	"Formation of HIV elongation complex in the absence of HIV Tat";"Pausing and recovery of HIV elongation";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Pre-transcription Events";"Regulation of expression of SLITs and ROBOs";"Tat-mediated HIV elongation arrest and recovery";"Formation of RNA Pol II elongation complex";"RNA Polymerase II Transcription Elongation";"Antigen processing: Ubiquitination & Proteasome degradation";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"HIV elongation arrest and recovery";"Vif-mediated degradation of APOBEC3G";"Pausing and recovery of Tat-mediated HIV elongation";"Tat-mediated elongation of the HIV-1 transcript";"Neddylation"
XP_046430579.1	2	Reactome: R-HSA-975957;Reactome: R-HSA-975956	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"
XP_046412463.1	1	Reactome: R-HSA-110362	"POLB-Dependent Long Patch Base Excision Repair"
XP_046427179.1	11	KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;Reactome: R-HSA-450302;KEGG: 05163+2.7.11.1;Reactome: R-HSA-171007;Reactome: R-HSA-4420097;Reactome: R-HSA-2559580;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1	"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Relaxin signaling pathway";"activated TAK1 mediates p38 MAPK activation";"Human cytomegalovirus infection";"p38MAPK events";"VEGFA-VEGFR2 Pathway";"Oxidative Stress Induced Senescence";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Thermogenesis"
XP_046432460.1	4	MetaCyc: PWY-5188;Reactome: R-HSA-189451;KEGG: 00860+4.2.1.75;MetaCyc: PWY-5189	"Tetrapyrrole biosynthesis I (from glutamate)";"Heme biosynthesis";"Porphyrin and chlorophyll metabolism";"Tetrapyrrole biosynthesis II (from glycine)"
XP_046428595.1	1	Reactome: R-HSA-75153	"Apoptotic execution phase"
XP_046411771.1	1	Reactome: R-HSA-83936	"Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"
XP_046413675.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_046420906.1	2	Reactome: R-HSA-8936459;Reactome: R-HSA-3214841	"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"PKMTs methylate histone lysines"
XP_046413880.1	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_046430369.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046430584.1	1	Reactome: R-HSA-426117	"Cation-coupled Chloride cotransporters"
XP_046425880.1	3	Reactome: R-HSA-418359;Reactome: R-HSA-936837;Reactome: R-HSA-5578775	"Reduction of cytosolic Ca++ levels";"Ion transport by P-type ATPases";"Ion homeostasis"
XP_046430024.1	2	Reactome: R-HSA-427413;Reactome: R-HSA-3214815	"NoRC negatively regulates rRNA expression";"HDACs deacetylate histones"
XP_046413614.1	1	Reactome: R-HSA-6809371	"Formation of the cornified envelope"
XP_046419042.1	1	Reactome: R-HSA-389977	"Post-chaperonin tubulin folding pathway"
XP_046419736.1	2	Reactome: R-HSA-1268020;Reactome: R-HSA-71403	"Mitochondrial protein import";"Citric acid cycle (TCA cycle)"
XP_046411625.1	2	Reactome: R-HSA-3238698;Reactome: R-HSA-373080	"WNT ligand biogenesis and trafficking";"Class B/2 (Secretin family receptors)"
XP_046420231.1	10	Reactome: R-HSA-8936459;Reactome: R-HSA-400206;Reactome: R-HSA-9615017;Reactome: R-HSA-9022702;Reactome: R-HSA-3899300;Reactome: R-HSA-9022538;Reactome: R-HSA-9022699;Reactome: R-HSA-9022692;Reactome: R-HSA-983231;Reactome: R-HSA-427413	"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Regulation of lipid metabolism by PPARalpha";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"MECP2 regulates transcription of neuronal ligands";"SUMOylation of transcription cofactors";"Loss of MECP2 binding ability to 5mC-DNA";"MECP2 regulates neuronal receptors and channels";"Regulation of MECP2 expression and activity";"Factors involved in megakaryocyte development and platelet production";"NoRC negatively regulates rRNA expression"
XP_046411189.1	2	Reactome: R-HSA-376176;Reactome: R-HSA-5663220	"Signaling by ROBO receptors";"RHO GTPases Activate Formins"
XP_046430602.1	1	Reactome: R-HSA-197264	"Nicotinamide salvaging"
XP_046426541.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_046427408.1	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
XP_046410601.1	1	Reactome: R-HSA-6799198	"Complex I biogenesis"
XP_046435360.1	6	MetaCyc: PWY-6983;MetaCyc: PWY-7442;KEGG: 00790+4.2.3.12;MetaCyc: PWY-5663;Reactome: R-HSA-1474151;MetaCyc: PWY-5664	"Threo-tetrahydrobiopterin biosynthesis";"Drosopterin and aurodrosopterin biosynthesis";"Folate biosynthesis";"Erythro-tetrahydrobiopterin biosynthesis I";"Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation";"Erythro-tetrahydrobiopterin biosynthesis II"
XP_046411869.1	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276	"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination"
XP_046432808.1	2	Reactome: R-HSA-1989781;Reactome: R-HSA-381340	"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation"
XP_046413981.1	8	KEGG: 04714+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;Reactome: R-HSA-2028269;KEGG: 04151+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1	"Thermogenesis";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"Signaling by Hippo";"PI3K-Akt signaling pathway";"Human cytomegalovirus infection";"Relaxin signaling pathway"
XP_046424285.1	2	Reactome: R-HSA-2142700;Reactome: R-HSA-2142691	"Synthesis of Lipoxins (LX)";"Synthesis of Leukotrienes (LT) and Eoxins (EX)"
XP_046432770.1	1	Reactome: R-HSA-5628897	"TP53 Regulates Metabolic Genes"
XP_046410513.1	6	KEGG: 00561+2.7.1.107;MetaCyc: PWY-7039;MetaCyc: PWY-7817;KEGG: 00564+2.7.1.107;Reactome: R-HSA-114508;KEGG: 04070+2.7.1.107	"Glycerolipid metabolism";"Phosphatidate metabolism, as a signaling molecule";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Glycerophospholipid metabolism";"Effects of PIP2 hydrolysis";"Phosphatidylinositol signaling system"
XP_046410107.1	1	Reactome: R-HSA-2151201	"Transcriptional activation of mitochondrial biogenesis"
XP_046409616.1	4	Reactome: R-HSA-4717374;Reactome: R-HSA-162699;Reactome: R-HSA-4719360;Reactome: R-HSA-4719377	"Defective DPM1 causes DPM1-CDG (CDG-1e)";"Synthesis of dolichyl-phosphate mannose";"Defective DPM3 causes DPM3-CDG (CDG-1o)";"Defective DPM2 causes DPM2-CDG (CDG-1u)"
XP_046427447.1	11	Reactome: R-HSA-446205;MetaCyc: PWY-3861;MetaCyc: PWY-5659;MetaCyc: PWY-7456;MetaCyc: PWY-6992;KEGG: 00051+5.3.1.8;MetaCyc: PWY-7586;MetaCyc: PWY-882;Reactome: R-HSA-4043916;KEGG: 00520+5.3.1.8;MetaCyc: PWY-3881	"Synthesis of GDP-mannose";"Mannitol degradation II";"GDP-mannose biosynthesis";"Beta-(1,4)-mannan degradation";"1,5-anhydrofructose degradation";"Fructose and mannose metabolism";"Beta-1,4-d-mannosyl-n-acetyl-d-glucosamine degradation";"L-ascorbate biosynthesis I (L-galactose pathway)";"Defective MPI causes MPI-CDG (CDG-1b)";"Amino sugar and nucleotide sugar metabolism";"Mannitol biosynthesis"
XP_046418344.1	1	Reactome: R-HSA-9022692	"Regulation of MECP2 expression and activity"
XP_046429569.1	2	Reactome: R-HSA-8951664;Reactome: R-HSA-983168	"Neddylation";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046433330.1	3	Reactome: R-HSA-3108214;Reactome: R-HSA-5693571;Reactome: R-HSA-164843	"SUMOylation of DNA damage response and repair proteins";"Nonhomologous End-Joining (NHEJ)";"2-LTR circle formation"
XP_046428654.1	1	Reactome: R-HSA-525793	"Myogenesis"
XP_046423526.1	2	Reactome: R-HSA-190873;Reactome: R-HSA-399719	"Gap junction degradation";"Trafficking of AMPA receptors"
XP_046427730.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_046412777.1	4	KEGG: 00983+6.3.5.2;MetaCyc: PWY-7221;KEGG: 00230+6.3.5.2;Reactome: R-HSA-73817	"Drug metabolism - other enzymes";"Guanosine ribonucleotides de novo biosynthesis";"Purine metabolism";"Purine ribonucleoside monophosphate biosynthesis"
XP_046434692.1	3	MetaCyc: PWY-6596;KEGG: 00230+3.5.4.6;Reactome: R-HSA-74217	"Adenosine nucleotides degradation I";"Purine metabolism";"Purine salvage"
XP_046424008.1	1	Reactome: R-HSA-8873719	"RAB geranylgeranylation"
XP_046420624.1	1	Reactome: R-HSA-525793	"Myogenesis"
XP_046430943.1	1	Reactome: R-HSA-8854691	"Interleukin-20 family signaling"
XP_046418359.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046427419.1	9	KEGG: 04714+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05163+2.7.11.1;Reactome: R-HSA-6804756;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;Reactome: R-HSA-6782315;KEGG: 04151+2.7.11.1	"Thermogenesis";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Human cytomegalovirus infection";"Regulation of TP53 Activity through Phosphorylation";"Relaxin signaling pathway";"mTOR signaling pathway";"tRNA modification in the nucleus and cytosol";"PI3K-Akt signaling pathway"
XP_046426214.1	3	Reactome: R-HSA-416482;Reactome: R-HSA-194840;Reactome: R-HSA-193648	"G alpha (12/13) signalling events";"Rho GTPase cycle";"NRAGE signals death through JNK"
XP_046417348.1	8	Reactome: R-HSA-380972;Reactome: R-HSA-1445148;Reactome: R-HSA-2151209;Reactome: R-HSA-9619483;Reactome: R-HSA-1632852;Reactome: R-HSA-9613354;Reactome: R-HSA-5628897;Reactome: R-HSA-6804756	"Energy dependent regulation of mTOR by LKB1-AMPK";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Activation of PPARGC1A (PGC-1alpha) by phosphorylation";"Activation of AMPK downstream of NMDARs";"Macroautophagy";"Lipophagy";"TP53 Regulates Metabolic Genes";"Regulation of TP53 Activity through Phosphorylation"
XP_046413970.1	1	Reactome: R-HSA-112308	"Presynaptic depolarization and calcium channel opening"
XP_046419126.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_046435374.1	2	Reactome: R-HSA-8856825;Reactome: R-HSA-8856828	"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis"
XP_046431609.1	2	Reactome: R-HSA-5693554;Reactome: R-HSA-2564830	"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Cytosolic iron-sulfur cluster assembly"
XP_046417663.1	1	Reactome: R-HSA-2470946	"Cohesin Loading onto Chromatin"
XP_046427671.1	3	Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-212436	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"Generic Transcription Pathway"
XP_046428733.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046419845.1	3	KEGG: 00730+3.1.3.2;KEGG: 00740+3.1.3.2;MetaCyc: PWY-6348	"Thiamine metabolism";"Riboflavin metabolism";"Phosphate acquisition"
XP_046414609.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_046433404.1	9	MetaCyc: PWY-6703;MetaCyc: PWY-6983;MetaCyc: PWY-5663;MetaCyc: PWY-7852;MetaCyc: PWY-5664;MetaCyc: PWY-7442;KEGG: 00790+3.5.4.16;MetaCyc: PWY-6147;Reactome: R-HSA-1474151	"Preq0 biosynthesis";"Threo-tetrahydrobiopterin biosynthesis";"Erythro-tetrahydrobiopterin biosynthesis I";"6-hydroxymethyl-dihydropterin diphosphate biosynthesis IV (Plasmodium)";"Erythro-tetrahydrobiopterin biosynthesis II";"Drosopterin and aurodrosopterin biosynthesis";"Folate biosynthesis";"6-hydroxymethyl-dihydropterin diphosphate biosynthesis I";"Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation"
XP_046425983.1	1	Reactome: R-HSA-399956	"CRMPs in Sema3A signaling"
XP_046413595.1	5	Reactome: R-HSA-1445148;Reactome: R-HSA-75035;Reactome: R-HSA-5628897;Reactome: R-HSA-111447;Reactome: R-HSA-5625740	"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex";"TP53 Regulates Metabolic Genes";"Activation of BAD and translocation to mitochondria";"RHO GTPases activate PKNs"
XP_046416807.1	2	Reactome: R-HSA-8949664;Reactome: R-HSA-8949215	"Processing of SMDT1";"Mitochondrial calcium ion transport"
XP_046424993.1	1	Reactome: R-HSA-1483101	"Synthesis of PS"
XP_046418371.1	2	Reactome: R-HSA-6783310;Reactome: R-HSA-5693568	"Fanconi Anemia Pathway";"Resolution of D-loop Structures through Holliday Junction Intermediates"
XP_046431327.1	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
XP_046430252.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046418892.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_046435383.1	2	Reactome: R-HSA-8856825;Reactome: R-HSA-8856828	"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis"
XP_046419808.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046419725.1	6	Reactome: R-HSA-68877;Reactome: R-HSA-2467813;Reactome: R-HSA-9648025;Reactome: R-HSA-141444;Reactome: R-HSA-5663220;Reactome: R-HSA-2500257	"Mitotic Prometaphase";"Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"RHO GTPases Activate Formins";"Resolution of Sister Chromatid Cohesion"
XP_046413325.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046415769.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_046422870.1	1	Reactome: R-HSA-6794361	"Neurexins and neuroligins"
XP_046431718.1	1	Reactome: R-HSA-6809371	"Formation of the cornified envelope"
XP_046410495.1	8	Reactome: R-HSA-174411;Reactome: R-HSA-68962;Reactome: R-HSA-69183;Reactome: R-HSA-69166;Reactome: R-HSA-174430;Reactome: R-HSA-113501;Reactome: R-HSA-68952;Reactome: R-HSA-69091	"Polymerase switching on the C-strand of the telomere";"Activation of the pre-replicative complex";"Processive synthesis on the lagging strand";"Removal of the Flap Intermediate";"Telomere C-strand synthesis initiation";"Inhibition of replication initiation of damaged DNA by RB1/E2F1";"DNA replication initiation";"Polymerase switching"
XP_046411466.1	2	MetaCyc: PWY-7221;KEGG: 00230+2.7.4.8	"Guanosine ribonucleotides de novo biosynthesis";"Purine metabolism"
XP_046433115.1	7	Reactome: R-HSA-2468052;Reactome: R-HSA-3108214;Reactome: R-HSA-2467813;Reactome: R-HSA-9018519;Reactome: R-HSA-1221632;Reactome: R-HSA-2470946;Reactome: R-HSA-2500257	"Establishment of Sister Chromatid Cohesion";"SUMOylation of DNA damage response and repair proteins";"Separation of Sister Chromatids";"Estrogen-dependent gene expression";"Meiotic synapsis";"Cohesin Loading onto Chromatin";"Resolution of Sister Chromatid Cohesion"
XP_046430054.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046432537.1	5	MetaCyc: PWY-6527;KEGG: 00052+3.2.1.22;KEGG: 00603+3.2.1.22;KEGG: 00600+3.2.1.22;KEGG: 00561+3.2.1.22	"Stachyose degradation";"Galactose metabolism";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Sphingolipid metabolism";"Glycerolipid metabolism"
XP_046420037.1	2	Reactome: R-HSA-8953750;Reactome: R-HSA-8939243	"Transcriptional Regulation by E2F6";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"
XP_046436444.1	5	Reactome: R-HSA-450321;Reactome: R-HSA-2559580;Reactome: R-HSA-450341;Reactome: R-HSA-2871796;KEGG: 04150+2.7.11.24	"JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1";"Oxidative Stress Induced Senescence";"Activation of the AP-1 family of transcription factors";"FCERI mediated MAPK activation";"mTOR signaling pathway"
XP_046431263.1	3	Reactome: R-HSA-2142691;MetaCyc: PWY-7533;Reactome: R-HSA-5423646	"Synthesis of Leukotrienes (LT) and Eoxins (EX)";"Gliotoxin biosynthesis";"Aflatoxin activation and detoxification"
XP_046428471.1	3	Reactome: R-HSA-2206291;Reactome: R-HSA-6798695;Reactome: R-HSA-2024096	"MPS IIIC - Sanfilippo syndrome C";"Neutrophil degranulation";"HS-GAG degradation"
XP_046427448.1	11	KEGG: 00520+5.3.1.8;MetaCyc: PWY-882;Reactome: R-HSA-4043916;MetaCyc: PWY-3881;KEGG: 00051+5.3.1.8;MetaCyc: PWY-7586;Reactome: R-HSA-446205;MetaCyc: PWY-3861;MetaCyc: PWY-5659;MetaCyc: PWY-7456;MetaCyc: PWY-6992	"Amino sugar and nucleotide sugar metabolism";"L-ascorbate biosynthesis I (L-galactose pathway)";"Defective MPI causes MPI-CDG (CDG-1b)";"Mannitol biosynthesis";"Fructose and mannose metabolism";"Beta-1,4-d-mannosyl-n-acetyl-d-glucosamine degradation";"Synthesis of GDP-mannose";"Mannitol degradation II";"GDP-mannose biosynthesis";"Beta-(1,4)-mannan degradation";"1,5-anhydrofructose degradation"
XP_046435078.1	7	KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1	"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Relaxin signaling pathway";"Thermogenesis";"Human cytomegalovirus infection";"mTOR signaling pathway";"PI3K-Akt signaling pathway"
XP_046420690.1	2	KEGG: 00970+6.1.1.20;Reactome: R-HSA-379716	"Aminoacyl-tRNA biosynthesis";"Cytosolic tRNA aminoacylation"
XP_046434648.1	1	Reactome: R-HSA-209968	"Thyroxine biosynthesis"
XP_046425361.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_046431659.1	13	Reactome: R-HSA-1660662;Reactome: R-HSA-2022857;MetaCyc: PWY-7883;KEGG: 00604+3.2.1.52;KEGG: 00603+3.2.1.52;KEGG: 00511+3.2.1.52;KEGG: 00513+3.2.1.52;MetaCyc: PWY-7822;MetaCyc: PWY-6902;KEGG: 00531+3.2.1.52;Reactome: R-HSA-2160916;KEGG: 00520+3.2.1.52;Reactome: R-HSA-2024101	"Glycosphingolipid metabolism";"Keratan sulfate degradation";"Anhydromuropeptides recycling II";"Glycosphingolipid biosynthesis - ganglio series";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Other glycan degradation";"Various types of N-glycan biosynthesis";"Chitin degradation III (Serratia)";"Chitin degradation II (Vibrio)";"Glycosaminoglycan degradation";"Hyaluronan uptake and degradation";"Amino sugar and nucleotide sugar metabolism";"CS/DS degradation"
XP_046410847.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046421051.1	1	Reactome: R-HSA-5693571	"Nonhomologous End-Joining (NHEJ)"
XP_046419176.1	2	Reactome: R-HSA-390471;Reactome: R-HSA-1660662	"Association of TriC/CCT with target proteins during biosynthesis";"Glycosphingolipid metabolism"
XP_046420421.1	4	Reactome: R-HSA-5693568;Reactome: R-HSA-5693554;Reactome: R-HSA-5685942;Reactome: R-HSA-5693579	"Resolution of D-loop Structures through Holliday Junction Intermediates";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"HDR through Homologous Recombination (HRR)";"Homologous DNA Pairing and Strand Exchange"
XP_046428152.1	2	Reactome: R-HSA-5689896;Reactome: R-HSA-195253	"Ovarian tumor domain proteases";"Degradation of beta-catenin by the destruction complex"
XP_046411639.1	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
XP_046427152.1	2	Reactome: R-HSA-72165;Reactome: R-HSA-72163	"mRNA Splicing - Minor Pathway";"mRNA Splicing - Major Pathway"
XP_046430196.1	2	Reactome: R-HSA-2682334;Reactome: R-HSA-3928665	"EPH-Ephrin signaling";"EPH-ephrin mediated repulsion of cells"
XP_046412273.1	7	KEGG: 00250+4.3.2.2;MetaCyc: PWY-7219;MetaCyc: PWY-6123;KEGG: 00230+4.3.2.2;MetaCyc: PWY-7234;Reactome: R-HSA-73817;MetaCyc: PWY-6124	"Alanine, aspartate and glutamate metabolism";"Adenosine ribonucleotides de novo biosynthesis";"Inosine-5'-phosphate biosynthesis I";"Purine metabolism";"Inosine-5'-phosphate biosynthesis III";"Purine ribonucleoside monophosphate biosynthesis";"Inosine-5'-phosphate biosynthesis II"
XP_046425520.1	2	Reactome: R-HSA-380270;Reactome: R-HSA-380320	"Recruitment of mitotic centrosome proteins and complexes";"Recruitment of NuMA to mitotic centrosomes"
XP_046433518.1	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
XP_046420477.1	2	Reactome: R-HSA-2022854;Reactome: R-HSA-975577	"Keratan sulfate biosynthesis";"N-Glycan antennae elongation"
XP_046433627.1	1	MetaCyc: PWY-7799	"Arg/N-end rule pathway (eukaryotic)"
XP_046425308.1	3	Reactome: R-HSA-193648;Reactome: R-HSA-416482;Reactome: R-HSA-194840	"NRAGE signals death through JNK";"G alpha (12/13) signalling events";"Rho GTPase cycle"
XP_046422772.1	4	KEGG: 00520+3.2.1.14;MetaCyc: PWY-7822;MetaCyc: PWY-6902;MetaCyc: PWY-6855	"Amino sugar and nucleotide sugar metabolism";"Chitin degradation III (Serratia)";"Chitin degradation II (Vibrio)";"Chitin degradation I (archaea)"
XP_046429620.1	3	Reactome: R-HSA-6807878;Reactome: R-HSA-6811440;Reactome: R-HSA-6811438	"COPI-mediated anterograde transport";"Retrograde transport at the Trans-Golgi-Network";"Intra-Golgi traffic"
XP_046429318.1	26	Reactome: R-HSA-380320;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813;Reactome: R-HSA-9609690;Reactome: R-HSA-6811434;Reactome: R-HSA-5626467;Reactome: R-HSA-6807878;Reactome: R-HSA-9619483;Reactome: R-HSA-983189;Reactome: R-HSA-389960;Reactome: R-HSA-2500257;Reactome: R-HSA-1445148;Reactome: R-HSA-9609736;Reactome: R-HSA-8955332;Reactome: R-HSA-9646399;Reactome: R-HSA-190861;Reactome: R-HSA-6811436;Reactome: R-HSA-190840;Reactome: R-HSA-8852276;Reactome: R-HSA-68877;Reactome: R-HSA-5617833;Reactome: R-HSA-2132295;Reactome: R-HSA-3371497;Reactome: R-HSA-437239;Reactome: R-HSA-389977;Reactome: R-HSA-5663220	"Recruitment of NuMA to mitotic centrosomes";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids";"HCMV Early Events";"COPI-dependent Golgi-to-ER retrograde traffic";"RHO GTPases activate IQGAPs";"COPI-mediated anterograde transport";"Activation of AMPK downstream of NMDARs";"Kinesins";"Formation of tubulin folding intermediates by CCT/TriC";"Resolution of Sister Chromatid Cohesion";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Assembly and cell surface presentation of NMDA receptors";"Carboxyterminal post-translational modifications of tubulin";"Aggrephagy";"Gap junction assembly";"COPI-independent Golgi-to-ER retrograde traffic";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Mitotic Prometaphase";"Cilium Assembly";"MHC class II antigen presentation";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Recycling pathway of L1";"Post-chaperonin tubulin folding pathway";"RHO GTPases Activate Formins"
XP_046428077.1	12	MetaCyc: PWY-5872;MetaCyc: PWY-5873;MetaCyc: PWY-5871;KEGG: 00130+1.14.99.60;Reactome: R-HSA-2142789;MetaCyc: PWY-5855;MetaCyc: PWY-5857;MetaCyc: PWY-7230;MetaCyc: PWY-6708;MetaCyc: PWY-7233;MetaCyc: PWY-5856;MetaCyc: PWY-5870	"Ubiquinol-10 biosynthesis (eukaryotic)";"Ubiquinol-7 biosynthesis (eukaryotic)";"Ubiquinol-9 biosynthesis (eukaryotic)";"Ubiquinone and other terpenoid-quinone biosynthesis";"Ubiquinol biosynthesis";"Ubiquinol-7 biosynthesis (prokaryotic)";"Ubiquinol-10 biosynthesis (prokaryotic)";"Ubiquinol-6 biosynthesis from 4-aminobenzoate (yeast)";"Ubiquinol-8 biosynthesis (prokaryotic)";"Ubiquinol-6 bypass biosynthesis (eukaryotic)";"Ubiquinol-9 biosynthesis (prokaryotic)";"Ubiquinol-8 biosynthesis (eukaryotic)"
XP_046427452.1	11	MetaCyc: PWY-7586;KEGG: 00051+5.3.1.8;MetaCyc: PWY-6992;MetaCyc: PWY-5659;MetaCyc: PWY-7456;Reactome: R-HSA-446205;MetaCyc: PWY-3861;MetaCyc: PWY-3881;MetaCyc: PWY-882;Reactome: R-HSA-4043916;KEGG: 00520+5.3.1.8	"Beta-1,4-d-mannosyl-n-acetyl-d-glucosamine degradation";"Fructose and mannose metabolism";"1,5-anhydrofructose degradation";"GDP-mannose biosynthesis";"Beta-(1,4)-mannan degradation";"Synthesis of GDP-mannose";"Mannitol degradation II";"Mannitol biosynthesis";"L-ascorbate biosynthesis I (L-galactose pathway)";"Defective MPI causes MPI-CDG (CDG-1b)";"Amino sugar and nucleotide sugar metabolism"
XP_046413207.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046417207.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046435522.1	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
XP_046420689.1	2	Reactome: R-HSA-379716;KEGG: 00970+6.1.1.20	"Cytosolic tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis"
XP_046409680.1	2	Reactome: R-HSA-1237112;Reactome: R-HSA-8950505	"Methionine salvage pathway";"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"
XP_046417866.1	1	Reactome: R-HSA-196741	"Cobalamin (Cbl, vitamin B12) transport and metabolism"
XP_046418228.1	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840	"Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation"
XP_046427013.1	29	Reactome: R-HSA-5696400;Reactome: R-HSA-5685938;Reactome: R-HSA-5358565;Reactome: R-HSA-6782135;Reactome: R-HSA-110320;Reactome: R-HSA-5651801;Reactome: R-HSA-69166;Reactome: R-HSA-6783310;Reactome: R-HSA-110312;Reactome: R-HSA-5685942;Reactome: R-HSA-5693607;Reactome: R-HSA-912446;Reactome: R-HSA-174437;Reactome: R-HSA-5358606;Reactome: R-HSA-6782210;Reactome: R-HSA-3371511;Reactome: R-HSA-5656169;Reactome: R-HSA-176187;Reactome: R-HSA-5693616;Reactome: R-HSA-3108214;Reactome: R-HSA-5696395;Reactome: R-HSA-68962;Reactome: R-HSA-6804756;Reactome: R-HSA-69473;Reactome: R-HSA-5656121;Reactome: R-HSA-110314;Reactome: R-HSA-3371453;Reactome: R-HSA-5696397;Reactome: R-HSA-5655862	"Dual Incision in GG-NER";"HDR through Single Strand Annealing (SSA)";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"Dual incision in TC-NER";"Translesion Synthesis by POLH";"PCNA-Dependent Long Patch Base Excision Repair";"Removal of the Flap Intermediate";"Fanconi Anemia Pathway";"Translesion synthesis by REV1";"HDR through Homologous Recombination (HRR)";"Processing of DNA double-strand break ends";"Meiotic recombination";"Removal of the Flap Intermediate from the C-strand";"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"Gap-filling DNA repair synthesis and ligation in TC-NER";"HSF1 activation";"Termination of translesion DNA synthesis";"Activation of ATR in response to replication stress";"Presynaptic phase of homologous DNA pairing and strand exchange";"SUMOylation of DNA damage response and repair proteins";"Formation of Incision Complex in GG-NER";"Activation of the pre-replicative complex";"Regulation of TP53 Activity through Phosphorylation";"G2/M DNA damage checkpoint";"Translesion synthesis by POLI";"Recognition of DNA damage by PCNA-containing replication complex";"Regulation of HSF1-mediated heat shock response";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Translesion synthesis by POLK"
XP_046419903.1	4	Reactome: R-HSA-983712;Reactome: R-HSA-917977;Reactome: R-HSA-1222556;Reactome: R-HSA-77387	"Ion channel transport";"Transferrin endocytosis and recycling";"ROS and RNS production in phagocytes";"Insulin receptor recycling"
XP_046418792.1	2	Reactome: R-HSA-983168;Reactome: R-HSA-6798695	"Antigen processing: Ubiquitination & Proteasome degradation";"Neutrophil degranulation"
XP_046434984.1	4	Reactome: R-HSA-427389;Reactome: R-HSA-73762;Reactome: R-HSA-3214815;Reactome: R-HSA-8943724	"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"RNA Polymerase I Transcription Initiation";"HDACs deacetylate histones";"Regulation of PTEN gene transcription"
XP_046418039.1	8	Reactome: R-HSA-68616;Reactome: R-HSA-113507;Reactome: R-HSA-68689;Reactome: R-HSA-68867;Reactome: R-HSA-68949;Reactome: R-HSA-68962;Reactome: R-HSA-176187;Reactome: R-HSA-68827	"Assembly of the ORC complex at the origin of replication";"E2F-enabled inhibition of pre-replication complex formation";"CDC6 association with the ORC:origin complex";"Assembly of the pre-replicative complex";"Orc1 removal from chromatin";"Activation of the pre-replicative complex";"Activation of ATR in response to replication stress";"CDT1 association with the CDC6:ORC:origin complex"
XP_046410170.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_046409896.1	4	Reactome: R-HSA-975871;Reactome: R-HSA-975138;Reactome: R-HSA-6799198;Reactome: R-HSA-166058	"MyD88 cascade initiated on plasma membrane";"TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation";"Complex I biogenesis";"MyD88:MAL(TIRAP) cascade initiated on plasma membrane"
XP_046415665.1	3	Reactome: R-HSA-1660662;KEGG: 00600+3.1.4.12;MetaCyc: PWY-7277	"Glycosphingolipid metabolism";"Sphingolipid metabolism";"Sphingolipid biosynthesis (mammals)"
XP_046425102.1	11	Reactome: R-HSA-6804114;Reactome: R-HSA-1989781;Reactome: R-HSA-400253;Reactome: R-HSA-1368082;Reactome: R-HSA-9018519;Reactome: R-HSA-400206;Reactome: R-HSA-381340;Reactome: R-HSA-3214858;Reactome: R-HSA-1368108;Reactome: R-HSA-2426168;Reactome: R-HSA-2151201	"TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest";"PPARA activates gene expression";"Circadian Clock";"RORA activates gene expression";"Estrogen-dependent gene expression";"Regulation of lipid metabolism by PPARalpha";"Transcriptional regulation of white adipocyte differentiation";"RMTs methylate histone arginines";"BMAL1:CLOCK,NPAS2 activates circadian gene expression";"Activation of gene expression by SREBF (SREBP)";"Transcriptional activation of mitochondrial biogenesis"
XP_046413893.1	6	Reactome: R-HSA-69052;Reactome: R-HSA-68949;Reactome: R-HSA-68962;Reactome: R-HSA-176187;Reactome: R-HSA-68867;Reactome: R-HSA-176974	"Switching of origins to a post-replicative state";"Orc1 removal from chromatin";"Activation of the pre-replicative complex";"Activation of ATR in response to replication stress";"Assembly of the pre-replicative complex";"Unwinding of DNA"
XP_046410991.1	5	Reactome: R-HSA-1912399;Reactome: R-HSA-5083630;Reactome: R-HSA-1912408;Reactome: R-HSA-1912420;Reactome: R-HSA-350054	"Pre-NOTCH Processing in the Endoplasmic Reticulum";"Defective LFNG causes SCDO3";"Pre-NOTCH Transcription and Translation";"Pre-NOTCH Processing in Golgi";"Notch-HLH transcription pathway"
XP_046421484.1	8	Reactome: R-HSA-1632852;Reactome: R-HSA-6798695;Reactome: R-HSA-166208;Reactome: R-HSA-165159;Reactome: R-HSA-380972;Reactome: R-HSA-5628897;Reactome: R-HSA-8943724;Reactome: R-HSA-9639288	"Macroautophagy";"Neutrophil degranulation";"mTORC1-mediated signalling";"mTOR signalling";"Energy dependent regulation of mTOR by LKB1-AMPK";"TP53 Regulates Metabolic Genes";"Regulation of PTEN gene transcription";"Amino acids regulate mTORC1"
XP_046410073.1	6	Reactome: R-HSA-72689;Reactome: R-HSA-156827;Reactome: R-HSA-72706;Reactome: R-HSA-72695;Reactome: R-HSA-72702;Reactome: R-HSA-72649	"Formation of a pool of free 40S subunits";"L13a-mediated translational silencing of Ceruloplasmin expression";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Formation of the ternary complex, and subsequently, the 43S complex";"Ribosomal scanning and start codon recognition";"Translation initiation complex formation"
XP_046418384.1	1	Reactome: R-HSA-1483191	"Synthesis of PC"
XP_046414297.1	6	Reactome: R-HSA-9648025;Reactome: R-HSA-141444;Reactome: R-HSA-68877;Reactome: R-HSA-2467813;Reactome: R-HSA-5663220;Reactome: R-HSA-2500257	"EML4 and NUDC in mitotic spindle formation";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Mitotic Prometaphase";"Separation of Sister Chromatids";"RHO GTPases Activate Formins";"Resolution of Sister Chromatid Cohesion"
XP_046430904.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046423692.1	1	KEGG: 00970+6.1.1.7	"Aminoacyl-tRNA biosynthesis"
XP_046433916.1	1	Reactome: R-HSA-9633012	"Response of EIF2AK4 (GCN2) to amino acid deficiency"
XP_046432125.1	1	Reactome: R-HSA-5689880	"Ub-specific processing proteases"
XP_046415612.1	14	KEGG: 00561+2.3.1.51;MetaCyc: PWY-8055;KEGG: 00564+2.3.1.51;MetaCyc: PWY-6453;MetaCyc: PWY-8051;MetaCyc: PWY-5667;MetaCyc: PWY-7411;Reactome: R-HSA-1483166;MetaCyc: PWY-7587;MetaCyc: PWY-7589;MetaCyc: PWY-7782;MetaCyc: PWY-5981;MetaCyc: PWY-8053;MetaCyc: PWY-7417	"Glycerolipid metabolism";"Palmitoyl ethanolamide biosynthesis";"Glycerophospholipid metabolism";"Stigma estolide biosynthesis";"Anandamide biosynthesis I";"CDP-diacylglycerol biosynthesis I";"Phosphatidate biosynthesis (yeast)";"Synthesis of PA";"Oleate biosynthesis III (cyanobacteria)";"Palmitoleate biosynthesis III (cyanobacteria)";"Plasmalogen biosynthesis";"CDP-diacylglycerol biosynthesis III";"Anandamide biosynthesis II";"Phospholipid remodeling (phosphatidate, yeast)"
XP_046435020.1	5	Reactome: R-HSA-73772;Reactome: R-HSA-73762;Reactome: R-HSA-5250924;Reactome: R-HSA-73863;Reactome: R-HSA-427413	"RNA Polymerase I Promoter Escape";"RNA Polymerase I Transcription Initiation";"B-WICH complex positively regulates rRNA expression";"RNA Polymerase I Transcription Termination";"NoRC negatively regulates rRNA expression"
XP_046417801.1	5	Reactome: R-HSA-3247509;Reactome: R-HSA-3214858;Reactome: R-HSA-1266695;Reactome: R-HSA-201722;Reactome: R-HSA-8939243	"Chromatin modifying enzymes";"RMTs methylate histone arginines";"Interleukin-7 signaling";"Formation of the beta-catenin:TCF transactivating complex";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"
XP_046435266.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_046435450.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046433692.1	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
XP_046412846.1	2	MetaCyc: PWY-6111;KEGG: 00071+2.3.1.21	"Mitochondrial L-carnitine shuttle";"Fatty acid degradation"
XP_046414700.1	1	Reactome: R-HSA-432720	"Lysosome Vesicle Biogenesis"
XP_046435033.1	5	Reactome: R-HSA-2132295;Reactome: R-HSA-204005;Reactome: R-HSA-983170;Reactome: R-HSA-5694530;Reactome: R-HSA-1655829	"MHC class II antigen presentation";"COPII-mediated vesicle transport";"Antigen Presentation: Folding, assembly and peptide loading of class I MHC";"Cargo concentration in the ER";"Regulation of cholesterol biosynthesis by SREBP (SREBF)"
XP_046432757.1	1	Reactome: R-HSA-6794361	"Neurexins and neuroligins"
XP_046420692.1	4	Reactome: R-HSA-70263;KEGG: 00010+3.1.3.9;KEGG: 00500+3.1.3.9;KEGG: 00052+3.1.3.9	"Gluconeogenesis";"Glycolysis / Gluconeogenesis";"Starch and sucrose metabolism";"Galactose metabolism"
XP_046418964.1	1	Reactome: R-HSA-2024096	"HS-GAG degradation"
XP_046420656.1	1	Reactome: R-HSA-6785631	"ERBB2 Regulates Cell Motility"
XP_046412467.1	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046426435.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046422749.1	1	Reactome: R-HSA-156584	"Cytosolic sulfonation of small molecules"
XP_046420866.1	33	Reactome: R-HSA-3232142;Reactome: R-HSA-3371453;Reactome: R-HSA-2500257;Reactome: R-HSA-4551638;Reactome: R-HSA-9610379;Reactome: R-HSA-9648025;Reactome: R-HSA-159231;Reactome: R-HSA-3108214;Reactome: R-HSA-2467813;Reactome: R-HSA-1169408;Reactome: R-HSA-168271;Reactome: R-HSA-168276;Reactome: R-HSA-5619107;Reactome: R-HSA-159230;Reactome: R-HSA-191859;Reactome: R-HSA-4615885;Reactome: R-HSA-170822;Reactome: R-HSA-180910;Reactome: R-HSA-6784531;Reactome: R-HSA-165054;Reactome: R-HSA-4085377;Reactome: R-HSA-4570464;Reactome: R-HSA-159236;Reactome: R-HSA-141444;Reactome: R-HSA-9609690;Reactome: R-HSA-168325;Reactome: R-HSA-5663220;Reactome: R-HSA-168333;Reactome: R-HSA-159227;Reactome: R-HSA-3301854;Reactome: R-HSA-5578749;Reactome: R-HSA-180746;Reactome: R-HSA-68877	"SUMOylation of ubiquitinylation proteins";"Regulation of HSF1-mediated heat shock response";"Resolution of Sister Chromatid Cohesion";"SUMOylation of chromatin organization proteins";"HCMV Late Events";"EML4 and NUDC in mitotic spindle formation";"Transport of Mature mRNA Derived from an Intronless Transcript";"SUMOylation of DNA damage response and repair proteins";"Separation of Sister Chromatids";"ISG15 antiviral mechanism";"Transport of Ribonucleoproteins into the Host Nucleus";"NS1 Mediated Effects on Host Pathways";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Transport of the SLBP Dependant Mature mRNA";"snRNP Assembly";"SUMOylation of DNA replication proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Vpr-mediated nuclear import of PICs";"tRNA processing in the nucleus";"Rev-mediated nuclear export of HIV RNA";"SUMOylation of SUMOylation proteins";"SUMOylation of RNA binding proteins";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"HCMV Early Events";"Viral Messenger RNA Synthesis";"RHO GTPases Activate Formins";"NEP/NS2 Interacts with the Cellular Export Machinery";"Transport of the SLBP independent Mature mRNA";"Nuclear Pore Complex (NPC) Disassembly";"Transcriptional regulation by small RNAs";"Nuclear import of Rev protein";"Mitotic Prometaphase"
XP_046426095.1	1	MetaCyc: PWY-6829	"Trna methylation (yeast)"
XP_046425576.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046428472.1	3	Reactome: R-HSA-2024096;Reactome: R-HSA-6798695;Reactome: R-HSA-2206291	"HS-GAG degradation";"Neutrophil degranulation";"MPS IIIC - Sanfilippo syndrome C"
XP_046418471.1	1	Reactome: R-HSA-5601884	"PIWI-interacting RNA (piRNA) biogenesis"
XP_046413593.1	5	Reactome: R-HSA-111447;Reactome: R-HSA-5628897;Reactome: R-HSA-75035;Reactome: R-HSA-1445148;Reactome: R-HSA-5625740	"Activation of BAD and translocation to mitochondria";"TP53 Regulates Metabolic Genes";"Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"RHO GTPases activate PKNs"
XP_046433656.1	8	MetaCyc: PWY-922;MetaCyc: PWY-7391;MetaCyc: PWY-6174;Reactome: R-HSA-1989781;Reactome: R-HSA-2426168;KEGG: 00900+1.1.1.34;Reactome: R-HSA-191273;MetaCyc: PWY-7524	"Mevalonate pathway I";"Isoprene biosynthesis II (engineered)";"Mevalonate pathway II (archaea)";"PPARA activates gene expression";"Activation of gene expression by SREBF (SREBP)";"Terpenoid backbone biosynthesis";"Cholesterol biosynthesis";"Mevalonate pathway III (archaea)"
XP_046419006.1	2	Reactome: R-HSA-5357905;Reactome: R-HSA-5357956	"Regulation of TNFR1 signaling";"TNFR1-induced NFkappaB signaling pathway"
XP_046415010.1	7	Reactome: R-HSA-8964539;KEGG: 00471+3.5.1.2;KEGG: 00220+3.5.1.2;Reactome: R-HSA-210500;KEGG: 00250+3.5.1.2;MetaCyc: PWY-5921;Reactome: R-HSA-5628897	"Glutamate and glutamine metabolism";"D-Glutamine and D-glutamate metabolism";"Arginine biosynthesis";"Glutamate Neurotransmitter Release Cycle";"Alanine, aspartate and glutamate metabolism";"Glutaminyl-trnagln biosynthesis via transamidation";"TP53 Regulates Metabolic Genes"
XP_046421631.1	3	KEGG: 04070+2.7.4.24+2.7.4.21;Reactome: R-HSA-1855167;MetaCyc: PWY-6369	"Phosphatidylinositol signaling system";"Synthesis of pyrophosphates in the cytosol";"Inositol diphosphates biosynthesis"
XP_046425217.1	10	MetaCyc: PWY-4321;MetaCyc: PWY-6536;MetaCyc: PWY-6537;KEGG: 00640+2.6.1.19;Reactome: R-HSA-916853;KEGG: 00410+2.6.1.19;KEGG: 00650+2.6.1.19;KEGG: 00250+2.6.1.19;MetaCyc: PWY-6535;MetaCyc: PWY-5022	"L-glutamate degradation IV";"4-aminobutanoate degradation III";"4-aminobutanoate degradation II";"Propanoate metabolism";"Degradation of GABA";"beta-Alanine metabolism";"Butanoate metabolism";"Alanine, aspartate and glutamate metabolism";"4-aminobutanoate degradation I";"4-aminobutanoate degradation V"
XP_046428128.1	2	Reactome: R-HSA-195253;Reactome: R-HSA-5689896	"Degradation of beta-catenin by the destruction complex";"Ovarian tumor domain proteases"
XP_046409799.1	11	Reactome: R-HSA-525793;Reactome: R-HSA-983231;Reactome: R-HSA-8940973;Reactome: R-HSA-5693565;KEGG: 04660+2.7.10.2;Reactome: R-HSA-69231;Reactome: R-HSA-428890;Reactome: R-HSA-2029482;Reactome: R-HSA-5663213;Reactome: R-HSA-8939236;Reactome: R-HSA-5685938	"Myogenesis";"Factors involved in megakaryocyte development and platelet production";"RUNX2 regulates osteoblast differentiation";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"T cell receptor signaling pathway";"Cyclin D associated events in G1";"Role of ABL in ROBO-SLIT signaling";"Regulation of actin dynamics for phagocytic cup formation";"RHO GTPases Activate WASPs and WAVEs";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"HDR through Single Strand Annealing (SSA)"
XP_046436401.1	1	Reactome: R-HSA-6811436	"COPI-independent Golgi-to-ER retrograde traffic"
XP_046416651.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046412376.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_046421964.1	2	Reactome: R-HSA-418457;Reactome: R-HSA-1296052	"cGMP effects";"Ca2+ activated K+ channels"
XP_046418146.1	1	Reactome: R-HSA-1445148	"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
XP_046431772.1	3	Reactome: R-HSA-8856828;Reactome: R-HSA-8875656;Reactome: R-HSA-8854214	"Clathrin-mediated endocytosis";"MET receptor recycling";"TBC/RABGAPs"
XP_046434120.1	3	MetaCyc: PWY-5386;KEGG: 00620+4.4.1.5;Reactome: R-HSA-70268	"Methylglyoxal degradation I";"Pyruvate metabolism";"Pyruvate metabolism"
XP_046416360.1	1	Reactome: R-HSA-425561	"Sodium/Calcium exchangers"
XP_046420102.1	1	Reactome: R-HSA-1632852	"Macroautophagy"
XP_046424477.1	6	MetaCyc: PWY-7656;KEGG: 00073+1.2.1.84;MetaCyc: PWY-6733;Reactome: R-HSA-9640463;MetaCyc: PWY-5884;MetaCyc: PWY-7782	"Spodoptera littoralis pheromone biosynthesis";"Cutin, suberine and wax biosynthesis";"Sporopollenin precursors biosynthesis";"Wax biosynthesis";"Wax esters biosynthesis I";"Plasmalogen biosynthesis"
XP_046411285.1	18	MetaCyc: PWY-6643;KEGG: 00350+2.6.1.1;KEGG: 00710+2.6.1.1;KEGG: 00270+2.6.1.1;KEGG: 00960+2.6.1.1;MetaCyc: PWY-7117;KEGG: 00250+2.6.1.1;KEGG: 00220+2.6.1.1;KEGG: 00330+2.6.1.1;KEGG: 00401+2.6.1.1;KEGG: 00400+2.6.1.1;MetaCyc: PWY-6638;MetaCyc: PWY-5913;MetaCyc: PWY-7383;KEGG: 00950+2.6.1.1;MetaCyc: PWY-6642;MetaCyc: PWY-7115;KEGG: 00360+2.6.1.1	"Coenzyme M biosynthesis II";"Tyrosine metabolism";"Carbon fixation in photosynthetic organisms";"Cysteine and methionine metabolism";"Tropane, piperidine and pyridine alkaloid biosynthesis";"C4 photosynthetic carbon assimilation cycle, PEPCK type";"Alanine, aspartate and glutamate metabolism";"Arginine biosynthesis";"Arginine and proline metabolism";"Novobiocin biosynthesis";"Phenylalanine, tyrosine and tryptophan biosynthesis";"Sulfolactate degradation III";"Partial TCA cycle (obligate autotrophs)";"Anaerobic energy metabolism (invertebrates, cytosol)";"Isoquinoline alkaloid biosynthesis";"(R)-cysteate degradation";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"Phenylalanine metabolism"
XP_046415151.1	2	KEGG: 00230+2.7.4.8;MetaCyc: PWY-7221	"Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis"
XP_046435844.1	16	Reactome: R-HSA-6811558;Reactome: R-HSA-1963640;Reactome: R-HSA-1250347;Reactome: R-HSA-1251985;Reactome: R-HSA-5673001;Reactome: R-HSA-1250342;Reactome: R-HSA-6785631;Reactome: R-HSA-1236394;Reactome: R-HSA-1963642;Reactome: R-HSA-8863795;Reactome: R-HSA-1250196;Reactome: R-HSA-1257604;Reactome: R-HSA-8847993;Reactome: R-HSA-1227986;Reactome: R-HSA-9664565;Reactome: R-HSA-2219530	"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"GRB2 events in ERBB2 signaling";"SHC1 events in ERBB4 signaling";"Nuclear signaling by ERBB4";"RAF/MAP kinase cascade";"PI3K events in ERBB4 signaling";"ERBB2 Regulates Cell Motility";"Signaling by ERBB4";"PI3K events in ERBB2 signaling";"Downregulation of ERBB2 signaling";"SHC1 events in ERBB2 signaling";"PIP3 activates AKT signaling";"ERBB2 Activates PTK6 Signaling";"Signaling by ERBB2";"Signaling by ERBB2 KD Mutants";"Constitutive Signaling by Aberrant PI3K in Cancer"
XP_046422281.1	20	Reactome: R-HSA-6782210;Reactome: R-HSA-5685942;Reactome: R-HSA-5693607;Reactome: R-HSA-5651801;Reactome: R-HSA-174411;Reactome: R-HSA-110312;Reactome: R-HSA-5685938;Reactome: R-HSA-5696400;Reactome: R-HSA-6782135;Reactome: R-HSA-110320;Reactome: R-HSA-5655862;Reactome: R-HSA-110314;Reactome: R-HSA-5656121;Reactome: R-HSA-5696397;Reactome: R-HSA-69091;Reactome: R-HSA-6804756;Reactome: R-HSA-69473;Reactome: R-HSA-5656169;Reactome: R-HSA-5693616;Reactome: R-HSA-176187	"Gap-filling DNA repair synthesis and ligation in TC-NER";"HDR through Homologous Recombination (HRR)";"Processing of DNA double-strand break ends";"PCNA-Dependent Long Patch Base Excision Repair";"Polymerase switching on the C-strand of the telomere";"Translesion synthesis by REV1";"HDR through Single Strand Annealing (SSA)";"Dual Incision in GG-NER";"Dual incision in TC-NER";"Translesion Synthesis by POLH";"Translesion synthesis by POLK";"Recognition of DNA damage by PCNA-containing replication complex";"Translesion synthesis by POLI";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Polymerase switching";"Regulation of TP53 Activity through Phosphorylation";"G2/M DNA damage checkpoint";"Termination of translesion DNA synthesis";"Presynaptic phase of homologous DNA pairing and strand exchange";"Activation of ATR in response to replication stress"
XP_046420240.1	7	Reactome: R-HSA-1483166;KEGG: 00565+3.1.4.4;Reactome: R-HSA-2029485;Reactome: R-HSA-1483148;MetaCyc: PWY-3561;KEGG: 00564+3.1.4.4;MetaCyc: PWY-7039	"Synthesis of PA";"Ether lipid metabolism";"Role of phospholipids in phagocytosis";"Synthesis of PG";"Choline biosynthesis III";"Glycerophospholipid metabolism";"Phosphatidate metabolism, as a signaling molecule"
XP_046422645.1	1	Reactome: R-HSA-2022377	"Metabolism of Angiotensinogen to Angiotensins"
XP_046416537.1	6	Reactome: R-HSA-73856;Reactome: R-HSA-72163;Reactome: R-HSA-159236;Reactome: R-HSA-9010553;Reactome: R-HSA-72187;Reactome: R-HSA-975957	"RNA Polymerase II Transcription Termination";"mRNA Splicing - Major Pathway";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Regulation of expression of SLITs and ROBOs";"mRNA 3'-end processing";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
XP_046420446.1	7	Reactome: R-HSA-2644606;Reactome: R-HSA-9013507;Reactome: R-HSA-2122948;Reactome: R-HSA-2894862;Reactome: R-HSA-2691232;Reactome: R-HSA-2660826;Reactome: R-HSA-2979096	"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Activated NOTCH1 Transmits Signal to the Nucleus";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Constitutive Signaling by NOTCH1 HD Domain Mutants";"Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant";"NOTCH2 Activation and Transmission of Signal to the Nucleus"
XP_046414739.1	2	KEGG: 00563+2.4.1.198;Reactome: R-HSA-162710	"Glycosylphosphatidylinositol (GPI)-anchor biosynthesis";"Synthesis of glycosylphosphatidylinositol (GPI)"
XP_046429692.1	1	Reactome: R-HSA-388844	"Receptor-type tyrosine-protein phosphatases"
XP_046433824.1	7	KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1	"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Relaxin signaling pathway";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Human cytomegalovirus infection";"Thermogenesis"
XP_046433267.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046409955.1	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
XP_046425935.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046411912.1	1	Reactome: R-HSA-5221030	"TET1,2,3 and TDG demethylate DNA"
XP_046431853.1	14	Reactome: R-HSA-9018519;Reactome: R-HSA-8934593;Reactome: R-HSA-426486;Reactome: R-HSA-8943723;Reactome: R-HSA-1912408;Reactome: R-HSA-4086398;Reactome: R-HSA-8986944;Reactome: R-HSA-8948700;Reactome: R-HSA-5628897;Reactome: R-HSA-203927;Reactome: R-HSA-9022692;Reactome: R-HSA-5687128;Reactome: R-HSA-426496;Reactome: R-HSA-9029569	"Estrogen-dependent gene expression";"Regulation of RUNX1 Expression and Activity";"Small interfering RNA (siRNA) biogenesis";"Regulation of PTEN mRNA translation";"Pre-NOTCH Transcription and Translation";"Ca2+ pathway";"Transcriptional Regulation by MECP2";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"TP53 Regulates Metabolic Genes";"MicroRNA (miRNA) biogenesis";"Regulation of MECP2 expression and activity";"MAPK6/MAPK4 signaling";"Post-transcriptional silencing by small RNAs";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux"
XP_046427180.1	11	KEGG: 04714+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;Reactome: R-HSA-2559580;Reactome: R-HSA-450302;KEGG: 05163+2.7.11.1;Reactome: R-HSA-171007;Reactome: R-HSA-4420097;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1	"Thermogenesis";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Oxidative Stress Induced Senescence";"activated TAK1 mediates p38 MAPK activation";"Human cytomegalovirus infection";"p38MAPK events";"VEGFA-VEGFR2 Pathway";"Relaxin signaling pathway";"mTOR signaling pathway";"PI3K-Akt signaling pathway"
XP_046425117.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_046411352.1	3	Reactome: R-HSA-191859;Reactome: R-HSA-72163;Reactome: R-HSA-72165	"snRNP Assembly";"mRNA Splicing - Major Pathway";"mRNA Splicing - Minor Pathway"
XP_046421752.1	56	Reactome: R-HSA-5362768;Reactome: R-HSA-5676590;Reactome: R-HSA-9604323;Reactome: R-HSA-5358346;Reactome: R-HSA-69601;Reactome: R-HSA-69017;Reactome: R-HSA-195253;Reactome: R-HSA-174178;Reactome: R-HSA-2871837;Reactome: R-HSA-68949;Reactome: R-HSA-1169091;Reactome: R-HSA-382556;Reactome: R-HSA-4641258;Reactome: R-HSA-211733;Reactome: R-HSA-5632684;Reactome: R-HSA-450408;Reactome: R-HSA-5610780;Reactome: R-HSA-1236974;Reactome: R-HSA-9010553;Reactome: R-HSA-350562;Reactome: R-HSA-8941858;Reactome: R-HSA-5668541;Reactome: R-HSA-180534;Reactome: R-HSA-187577;Reactome: R-HSA-5607764;Reactome: R-HSA-68827;Reactome: R-HSA-5689603;Reactome: R-HSA-5610783;Reactome: R-HSA-8852276;Reactome: R-HSA-69481;Reactome: R-HSA-1234176;Reactome: R-HSA-8948751;Reactome: R-HSA-8854050;Reactome: R-HSA-9020702;Reactome: R-HSA-5687128;Reactome: R-HSA-174113;Reactome: R-HSA-8939902;Reactome: R-HSA-174184;Reactome: R-HSA-174154;Reactome: R-HSA-2467813;Reactome: R-HSA-983168;Reactome: R-HSA-5658442;Reactome: R-HSA-5607761;Reactome: R-HSA-5610785;Reactome: R-HSA-5678895;Reactome: R-HSA-180585;Reactome: R-HSA-8939236;Reactome: R-HSA-349425;Reactome: R-HSA-174084;Reactome: R-HSA-8951664;Reactome: R-HSA-5689880;Reactome: R-HSA-202424;Reactome: R-HSA-75815;Reactome: R-HSA-4641257;Reactome: R-HSA-4608870;Reactome: R-HSA-1236978	"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"NIK-->noncanonical NF-kB signaling";"Negative regulation of NOTCH4 signaling";"Hedgehog ligand biogenesis";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"CDK-mediated phosphorylation and removal of Cdc6";"Degradation of beta-catenin by the destruction complex";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"FCERI mediated NF-kB activation";"Orc1 removal from chromatin";"Activation of NF-kappaB in B cells";"ABC-family proteins mediated transport";"Degradation of DVL";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Hedgehog 'on' state";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Degradation of GLI1 by the proteasome";"ER-Phagosome pathway";"Regulation of expression of SLITs and ROBOs";"Regulation of ornithine decarboxylase (ODC)";"Regulation of RUNX3 expression and activity";"TNFR2 non-canonical NF-kB pathway";"Vpu mediated degradation of CD4";"SCF(Skp2)-mediated degradation of p27/p21";"CLEC7A (Dectin-1) signaling";"CDT1 association with the CDC6:ORC:origin complex";"UCH proteinases";"Degradation of GLI2 by the proteasome";"The role of GTSE1 in G2/M progression after G2 checkpoint";"G2/M Checkpoints";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of PTEN stability and activity";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Interleukin-1 signaling";"MAPK6/MAPK4 signaling";"SCF-beta-TrCP mediated degradation of Emi1";"Regulation of RUNX2 expression and activity";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"APC/C:Cdc20 mediated degradation of Securin";"Separation of Sister Chromatids";"Antigen processing: Ubiquitination & Proteasome degradation";"Regulation of RAS by GAPs";"Dectin-1 mediated noncanonical NF-kB signaling";"GLI3 is processed to GLI3R by the proteasome";"Defective CFTR causes cystic fibrosis";"Vif-mediated degradation of APOBEC3G";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Autodegradation of the E3 ubiquitin ligase COP1";"Autodegradation of Cdh1 by Cdh1:APC/C";"Neddylation";"Ub-specific processing proteases";"Downstream TCR signaling";"Ubiquitin-dependent degradation of Cyclin D";"Degradation of AXIN";"Asymmetric localization of PCP proteins";"Cross-presentation of soluble exogenous antigens (endosomes)"
XP_046419689.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_046433524.1	1	Reactome: R-HSA-5620912	"Anchoring of the basal body to the plasma membrane"
XP_046435900.1	2	Reactome: R-HSA-6807878;Reactome: R-HSA-445095	"COPI-mediated anterograde transport";"Interaction between L1 and Ankyrins"
XP_046414292.1	5	Reactome: R-HSA-73856;Reactome: R-HSA-77595;Reactome: R-HSA-6784531;Reactome: R-HSA-72187;Reactome: R-HSA-72163	"RNA Polymerase II Transcription Termination";"Processing of Intronless Pre-mRNAs";"tRNA processing in the nucleus";"mRNA 3'-end processing";"mRNA Splicing - Major Pathway"
XP_046435957.1	2	Reactome: R-HSA-6783310;Reactome: R-HSA-5693568	"Fanconi Anemia Pathway";"Resolution of D-loop Structures through Holliday Junction Intermediates"
XP_046430614.1	39	Reactome: R-HSA-5654710;Reactome: R-HSA-5654733;Reactome: R-HSA-5654689;Reactome: R-HSA-5654706;Reactome: R-HSA-5654688;Reactome: R-HSA-5654695;Reactome: R-HSA-5654727;Reactome: R-HSA-6811558;Reactome: R-HSA-5654687;Reactome: R-HSA-5654228;Reactome: R-HSA-190322;Reactome: R-HSA-5654726;Reactome: R-HSA-190375;Reactome: R-HSA-5654227;Reactome: R-HSA-5673001;Reactome: R-HSA-5654219;Reactome: R-HSA-5654712;Reactome: R-HSA-5658623;Reactome: R-HSA-5654732;Reactome: R-HSA-5655302;Reactome: R-HSA-190372;Reactome: R-HSA-1257604;Reactome: R-HSA-5654699;Reactome: R-HSA-5654700;Reactome: R-HSA-5654719;Reactome: R-HSA-5654221;Reactome: R-HSA-2033514;Reactome: R-HSA-190373;Reactome: R-HSA-5654693;Reactome: R-HSA-1839130;Reactome: R-HSA-8853338;Reactome: R-HSA-190371;Reactome: R-HSA-5655253;Reactome: R-HSA-109704;Reactome: R-HSA-1839122;Reactome: R-HSA-2219530;Reactome: R-HSA-2033519;Reactome: R-HSA-5654704;Reactome: R-HSA-5654720	"PI-3K cascade:FGFR3";"Negative regulation of FGFR4 signaling";"PI-3K cascade:FGFR1";"FRS-mediated FGFR3 signaling";"SHC-mediated cascade:FGFR1";"PI-3K cascade:FGFR2";"Negative regulation of FGFR2 signaling";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"Downstream signaling of activated FGFR1";"Phospholipase C-mediated cascade, FGFR4";"FGFR4 ligand binding and activation";"Negative regulation of FGFR1 signaling";"FGFR2c ligand binding and activation";"Phospholipase C-mediated cascade, FGFR3";"RAF/MAP kinase cascade";"Phospholipase C-mediated cascade: FGFR1";"FRS-mediated FGFR4 signaling";"FGFRL1 modulation of FGFR1 signaling";"Negative regulation of FGFR3 signaling";"Signaling by FGFR1 in disease";"FGFR3c ligand binding and activation";"PIP3 activates AKT signaling";"SHC-mediated cascade:FGFR2";"FRS-mediated FGFR2 signaling";"SHC-mediated cascade:FGFR4";"Phospholipase C-mediated cascade, FGFR2";"FGFR3 mutant receptor activation";"FGFR1c ligand binding and activation";"FRS-mediated FGFR1 signaling";"Signaling by activated point mutants of FGFR3";"Signaling by FGFR3 point mutants in cancer";"FGFR3b ligand binding and activation";"Signaling by FGFR2 in disease";"PI3K Cascade";"Signaling by activated point mutants of FGFR1";"Constitutive Signaling by Aberrant PI3K in Cancer";"Activated point mutants of FGFR2";"SHC-mediated cascade:FGFR3";"PI-3K cascade:FGFR4"
XP_046410082.1	13	Reactome: R-HSA-168638;Reactome: R-HSA-975163;Reactome: R-HSA-9645460;Reactome: R-HSA-9020702;Reactome: R-HSA-450321;Reactome: R-HSA-937042;Reactome: R-HSA-2871837;Reactome: R-HSA-450302;Reactome: R-HSA-9014325;Reactome: R-HSA-5607764;Reactome: R-HSA-5357956;Reactome: R-HSA-445989;Reactome: R-HSA-937072	"NOD1/2 Signaling Pathway";"IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation";"Alpha-protein kinase 1 signaling pathway";"Interleukin-1 signaling";"JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1";"IRAK2 mediated activation of TAK1 complex";"FCERI mediated NF-kB activation";"activated TAK1 mediates p38 MAPK activation";"TICAM1,TRAF6-dependent induction of TAK1 complex";"CLEC7A (Dectin-1) signaling";"TNFR1-induced NFkappaB signaling pathway";"TAK1 activates NFkB by phosphorylation and activation of IKKs complex";"TRAF6-mediated induction of TAK1 complex within TLR4 complex"
XP_046431332.1	2	Reactome: R-HSA-8949613;Reactome: R-HSA-163210	"Cristae formation";"Formation of ATP by chemiosmotic coupling"
XP_046435686.1	7	Reactome: R-HSA-166208;Reactome: R-HSA-156827;Reactome: R-HSA-72662;Reactome: R-HSA-429947;Reactome: R-HSA-72649;Reactome: R-HSA-72702;Reactome: R-HSA-72706	"mTORC1-mediated signalling";"L13a-mediated translational silencing of Ceruloplasmin expression";"Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S";"Deadenylation of mRNA";"Translation initiation complex formation";"Ribosomal scanning and start codon recognition";"GTP hydrolysis and joining of the 60S ribosomal subunit"
XP_046425099.1	11	Reactome: R-HSA-1368082;Reactome: R-HSA-9018519;Reactome: R-HSA-400253;Reactome: R-HSA-400206;Reactome: R-HSA-6804114;Reactome: R-HSA-1989781;Reactome: R-HSA-1368108;Reactome: R-HSA-2151201;Reactome: R-HSA-2426168;Reactome: R-HSA-381340;Reactome: R-HSA-3214858	"RORA activates gene expression";"Estrogen-dependent gene expression";"Circadian Clock";"Regulation of lipid metabolism by PPARalpha";"TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest";"PPARA activates gene expression";"BMAL1:CLOCK,NPAS2 activates circadian gene expression";"Transcriptional activation of mitochondrial biogenesis";"Activation of gene expression by SREBF (SREBP)";"Transcriptional regulation of white adipocyte differentiation";"RMTs methylate histone arginines"
XP_046430687.1	3	MetaCyc: PWY-7833;MetaCyc: PWY-7831;Reactome: R-HSA-9033807	"Biosynthesis of Lewis epitopes (H. pylori)";"ABH and Lewis epitopes biosynthesis from type 2 precursor disaccharide";"ABO blood group biosynthesis"
XP_046430514.1	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
XP_046415456.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_046416918.1	1	Reactome: R-HSA-5576886	"Phase 4 - resting membrane potential"
XP_046421571.1	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
XP_046420820.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046418775.1	3	Reactome: R-HSA-392154;Reactome: R-HSA-445355;KEGG: 00230+4.6.1.2	"Nitric oxide stimulates guanylate cyclase";"Smooth Muscle Contraction";"Purine metabolism"
XP_046416846.1	6	KEGG: 00073+1.2.1.84;MetaCyc: PWY-7656;Reactome: R-HSA-9640463;MetaCyc: PWY-6733;MetaCyc: PWY-5884;MetaCyc: PWY-7782	"Cutin, suberine and wax biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Wax biosynthesis";"Sporopollenin precursors biosynthesis";"Wax esters biosynthesis I";"Plasmalogen biosynthesis"
XP_046427442.1	5	Reactome: R-HSA-6814122;Reactome: R-HSA-390450;Reactome: R-HSA-390471;Reactome: R-HSA-389960;Reactome: R-HSA-389957	"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"Folding of actin by CCT/TriC";"Association of TriC/CCT with target proteins during biosynthesis";"Formation of tubulin folding intermediates by CCT/TriC";"Prefoldin mediated transfer of substrate to CCT/TriC"
XP_046436302.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_046427937.1	2	Reactome: R-HSA-1989781;Reactome: R-HSA-2151201	"PPARA activates gene expression";"Transcriptional activation of mitochondrial biogenesis"
XP_046430458.1	1	Reactome: R-HSA-1483191	"Synthesis of PC"
XP_046426242.1	1	Reactome: R-HSA-1474228	"Degradation of the extracellular matrix"
XP_046435358.1	6	MetaCyc: PWY-5664;Reactome: R-HSA-1474151;MetaCyc: PWY-5663;KEGG: 00790+4.2.3.12;MetaCyc: PWY-7442;MetaCyc: PWY-6983	"Erythro-tetrahydrobiopterin biosynthesis II";"Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation";"Erythro-tetrahydrobiopterin biosynthesis I";"Folate biosynthesis";"Drosopterin and aurodrosopterin biosynthesis";"Threo-tetrahydrobiopterin biosynthesis"
XP_046411112.1	2	Reactome: R-HSA-168138;Reactome: R-HSA-983231	"Toll Like Receptor 9 (TLR9) Cascade";"Factors involved in megakaryocyte development and platelet production"
XP_046415085.1	1	Reactome: R-HSA-2132295	"MHC class II antigen presentation"
XP_046420649.1	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
XP_046418338.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046416742.1	1	Reactome: R-HSA-5576886	"Phase 4 - resting membrane potential"
XP_046411245.1	1	Reactome: R-HSA-6811440	"Retrograde transport at the Trans-Golgi-Network"
XP_046435359.1	6	MetaCyc: PWY-5663;MetaCyc: PWY-6983;MetaCyc: PWY-7442;KEGG: 00790+4.2.3.12;Reactome: R-HSA-1474151;MetaCyc: PWY-5664	"Erythro-tetrahydrobiopterin biosynthesis I";"Threo-tetrahydrobiopterin biosynthesis";"Drosopterin and aurodrosopterin biosynthesis";"Folate biosynthesis";"Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation";"Erythro-tetrahydrobiopterin biosynthesis II"
XP_046422891.1	1	Reactome: R-HSA-427652	"Sodium-coupled phosphate cotransporters"
XP_046432088.1	7	KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1	"Thermogenesis";"Human cytomegalovirus infection";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Relaxin signaling pathway";"mTOR signaling pathway";"PI3K-Akt signaling pathway"
XP_046429151.1	5	Reactome: R-HSA-211981;Reactome: R-HSA-211945;Reactome: R-HSA-8937144;Reactome: R-HSA-211976;Reactome: R-HSA-1989781	"Xenobiotics";"Phase I - Functionalization of compounds";"Aryl hydrocarbon receptor signalling";"Endogenous sterols";"PPARA activates gene expression"
XP_046416978.1	1	Reactome: R-HSA-6794361	"Neurexins and neuroligins"
XP_046432450.1	5	Reactome: R-HSA-6807004;Reactome: R-HSA-8856828;Reactome: R-HSA-8875360;Reactome: R-HSA-8856825;Reactome: R-HSA-182971	"Negative regulation of MET activity";"Clathrin-mediated endocytosis";"InlB-mediated entry of Listeria monocytogenes into host cell";"Cargo recognition for clathrin-mediated endocytosis";"EGFR downregulation"
XP_046417198.1	9	Reactome: R-HSA-167172;Reactome: R-HSA-167162;Reactome: R-HSA-75953;Reactome: R-HSA-76042;Reactome: R-HSA-73779;Reactome: R-HSA-674695;Reactome: R-HSA-73776;Reactome: R-HSA-167161;Reactome: R-HSA-6804756	"Transcription of the HIV genome";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Promoter Escape";"HIV Transcription Initiation";"Regulation of TP53 Activity through Phosphorylation"
XP_046421705.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_046419149.1	2	Reactome: R-HSA-8939243;Reactome: R-HSA-3214858	"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RMTs methylate histone arginines"
XP_046418071.1	4	MetaCyc: PWY-5737;Reactome: R-HSA-70688;KEGG: 00330+1.5.5.2;MetaCyc: PWY-6922	"(5R)-carbapenem carboxylate biosynthesis";"Proline catabolism";"Arginine and proline metabolism";"L-Ndelta-acetylornithine biosynthesis"
XP_046435662.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-5628897	"Respiratory electron transport";"TP53 Regulates Metabolic Genes"
XP_046425177.1	1	Reactome: R-HSA-4615885	"SUMOylation of DNA replication proteins"
XP_046421251.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046422394.1	5	Reactome: R-HSA-2426168;Reactome: R-HSA-381183;Reactome: R-HSA-9614657;Reactome: R-HSA-1989781;Reactome: R-HSA-380994	"Activation of gene expression by SREBF (SREBP)";"ATF6 (ATF6-alpha) activates chaperone genes";"FOXO-mediated transcription of cell death genes";"PPARA activates gene expression";"ATF4 activates genes in response to endoplasmic reticulum stress"
XP_046421617.1	3	KEGG: 04070+2.7.4.24+2.7.4.21;Reactome: R-HSA-1855167;MetaCyc: PWY-6369	"Phosphatidylinositol signaling system";"Synthesis of pyrophosphates in the cytosol";"Inositol diphosphates biosynthesis"
XP_046418367.1	3	Reactome: R-HSA-416482;Reactome: R-HSA-194840;Reactome: R-HSA-193648	"G alpha (12/13) signalling events";"Rho GTPase cycle";"NRAGE signals death through JNK"
XP_046420978.1	1	Reactome: R-HSA-6784531	"tRNA processing in the nucleus"
XP_046422041.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046430476.1	4	Reactome: R-HSA-3769402;Reactome: R-HSA-4641265;Reactome: R-HSA-2122947;Reactome: R-HSA-201722	"Deactivation of the beta-catenin transactivating complex";"Repression of WNT target genes";"NOTCH1 Intracellular Domain Regulates Transcription";"Formation of the beta-catenin:TCF transactivating complex"
XP_046414187.1	1	Reactome: R-HSA-1660662	"Glycosphingolipid metabolism"
XP_046424503.1	9	Reactome: R-HSA-1475029;KEGG: 00910+4.2.1.1;MetaCyc: PWY-6142;MetaCyc: PWY-5789;MetaCyc: PWY-241;MetaCyc: PWY-5743;MetaCyc: PWY-7117;MetaCyc: PWY-5744;MetaCyc: PWY-7115	"Reversible hydration of carbon dioxide";"Nitrogen metabolism";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"3-hydroxypropanoate/4-hydroxybutanate cycle";"C4 photosynthetic carbon assimilation cycle, NADP-ME type";"3-hydroxypropanoate cycle";"C4 photosynthetic carbon assimilation cycle, PEPCK type";"Glyoxylate assimilation";"C4 photosynthetic carbon assimilation cycle, NAD-ME type"
XP_046436582.1	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
XP_046428739.1	1	Reactome: R-HSA-5368286	"Mitochondrial translation initiation"
XP_046430090.1	3	Reactome: R-HSA-947581;MetaCyc: PWY-6823;KEGG: 00790+2.10.1.1	"Molybdenum cofactor biosynthesis";"Molybdenum cofactor biosynthesis";"Folate biosynthesis"
XP_046412594.1	1	Reactome: R-HSA-419771	"Opsins"
XP_046412646.1	4	Reactome: R-HSA-2644606;Reactome: R-HSA-2122947;Reactome: R-HSA-2894862;Reactome: R-HSA-350054	"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH1 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Notch-HLH transcription pathway"
XP_046418289.1	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046421078.1	2	Reactome: R-HSA-72702;Reactome: R-HSA-72706	"Ribosomal scanning and start codon recognition";"GTP hydrolysis and joining of the 60S ribosomal subunit"
XP_046436192.1	1	Reactome: R-HSA-418594	"G alpha (i) signalling events"
XP_046424189.1	12	KEGG: 00520+2.7.7.9;KEGG: 00052+2.7.7.9;MetaCyc: PWY-7817;MetaCyc: PWY-7343;MetaCyc: PWY-7238;Reactome: R-HSA-3322077;KEGG: 00561+2.7.7.9;KEGG: 00500+2.7.7.9;MetaCyc: PWY-3801;Reactome: R-HSA-173599;MetaCyc: PWY-6527;KEGG: 00040+2.7.7.9	"Amino sugar and nucleotide sugar metabolism";"Galactose metabolism";"Type I lipoteichoic acid biosynthesis (S. aureus)";"UDP-alpha-D-glucose biosynthesis I";"Sucrose biosynthesis II";"Glycogen synthesis";"Glycerolipid metabolism";"Starch and sucrose metabolism";"Sucrose degradation II (sucrose synthase)";"Formation of the active cofactor, UDP-glucuronate";"Stachyose degradation";"Pentose and glucuronate interconversions"
XP_046426428.1	9	Reactome: R-HSA-9613829;Reactome: R-HSA-8856825;Reactome: R-HSA-9615710;Reactome: R-HSA-5689880;Reactome: R-HSA-9646399;Reactome: R-HSA-382556;Reactome: R-HSA-5627083;Reactome: R-HSA-8856828;Reactome: R-HSA-5678895	"Chaperone Mediated Autophagy";"Cargo recognition for clathrin-mediated endocytosis";"Late endosomal microautophagy";"Ub-specific processing proteases";"Aggrephagy";"ABC-family proteins mediated transport";"RHO GTPases regulate CFTR trafficking";"Clathrin-mediated endocytosis";"Defective CFTR causes cystic fibrosis"
XP_046412673.1	7	Reactome: R-HSA-8854518;Reactome: R-HSA-380259;Reactome: R-HSA-380320;Reactome: R-HSA-2565942;Reactome: R-HSA-380270;Reactome: R-HSA-5620912;Reactome: R-HSA-380284	"AURKA Activation by TPX2";"Loss of Nlp from mitotic centrosomes";"Recruitment of NuMA to mitotic centrosomes";"Regulation of PLK1 Activity at G2/M Transition";"Recruitment of mitotic centrosome proteins and complexes";"Anchoring of the basal body to the plasma membrane";"Loss of proteins required for interphase microtubule organization from the centrosome"
XP_046421358.1	7	KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1	"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Relaxin signaling pathway";"Thermogenesis";"Human cytomegalovirus infection"
XP_046410833.1	6	Reactome: R-HSA-3769402;Reactome: R-HSA-8986944;Reactome: R-HSA-6785807;Reactome: R-HSA-452723;Reactome: R-HSA-2892247;Reactome: R-HSA-2892245	"Deactivation of the beta-catenin transactivating complex";"Transcriptional Regulation by MECP2";"Interleukin-4 and Interleukin-13 signaling";"Transcriptional regulation of pluripotent stem cells";"POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation";"POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation"
XP_046421744.1	1	Reactome: R-HSA-1660661	"Sphingolipid de novo biosynthesis"
XP_046429441.1	1	Reactome: R-HSA-5625900	"RHO GTPases activate CIT"
XP_046410159.1	1	Reactome: R-HSA-5617472	"Activation of anterior HOX genes in hindbrain development during early embryogenesis"
XP_046418902.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_046424172.1	24	Reactome: R-HSA-5617833;Reactome: R-HSA-2132295;Reactome: R-HSA-8955332;Reactome: R-HSA-9609736;Reactome: R-HSA-8852276;Reactome: R-HSA-68877;Reactome: R-HSA-190840;Reactome: R-HSA-6811436;Reactome: R-HSA-9646399;Reactome: R-HSA-190861;Reactome: R-HSA-5663220;Reactome: R-HSA-437239;Reactome: R-HSA-3371497;Reactome: R-HSA-6811434;Reactome: R-HSA-9648025;Reactome: R-HSA-380320;Reactome: R-HSA-9609690;Reactome: R-HSA-2467813;Reactome: R-HSA-9619483;Reactome: R-HSA-1445148;Reactome: R-HSA-983189;Reactome: R-HSA-2500257;Reactome: R-HSA-5626467;Reactome: R-HSA-6807878	"Cilium Assembly";"MHC class II antigen presentation";"Carboxyterminal post-translational modifications of tubulin";"Assembly and cell surface presentation of NMDA receptors";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Mitotic Prometaphase";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"COPI-independent Golgi-to-ER retrograde traffic";"Aggrephagy";"Gap junction assembly";"RHO GTPases Activate Formins";"Recycling pathway of L1";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-dependent Golgi-to-ER retrograde traffic";"EML4 and NUDC in mitotic spindle formation";"Recruitment of NuMA to mitotic centrosomes";"HCMV Early Events";"Separation of Sister Chromatids";"Activation of AMPK downstream of NMDARs";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Kinesins";"Resolution of Sister Chromatid Cohesion";"RHO GTPases activate IQGAPs";"COPI-mediated anterograde transport"
XP_046425847.1	1	Reactome: R-HSA-71064	"Lysine catabolism"
XP_046424510.1	1	Reactome: R-HSA-1445148	"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
XP_046419760.1	4	KEGG: 00190+3.6.1.1;MetaCyc: PWY-7805;Reactome: R-HSA-71737;MetaCyc: PWY-7807	"Oxidative phosphorylation";"(aminomethyl)phosphonate degradation";"Pyrophosphate hydrolysis";"Glyphosate degradation III"
XP_046413040.1	3	Reactome: R-HSA-3000171;Reactome: R-HSA-8874081;Reactome: R-HSA-3000157	"Non-integrin membrane-ECM interactions";"MET activates PTK2 signaling";"Laminin interactions"
XP_046413227.1	1	Reactome: R-HSA-70221	"Glycogen breakdown (glycogenolysis)"
XP_046414768.1	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6784531	"Major pathway of rRNA processing in the nucleolus and cytosol";"tRNA processing in the nucleus"
XP_046423253.1	1	Reactome: R-HSA-72165	"mRNA Splicing - Minor Pathway"
XP_046425793.1	2	Reactome: R-HSA-110320;Reactome: R-HSA-983168	"Translesion Synthesis by POLH";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046427185.1	11	Reactome: R-HSA-450302;Reactome: R-HSA-171007;KEGG: 05163+2.7.11.1;Reactome: R-HSA-4420097;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;Reactome: R-HSA-2559580	"activated TAK1 mediates p38 MAPK activation";"p38MAPK events";"Human cytomegalovirus infection";"VEGFA-VEGFR2 Pathway";"Relaxin signaling pathway";"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Thermogenesis";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Oxidative Stress Induced Senescence"
XP_046412948.1	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
XP_046432706.1	1	Reactome: R-HSA-381753	"Olfactory Signaling Pathway"
XP_046427952.1	1	Reactome: R-HSA-156842	"Eukaryotic Translation Elongation"
XP_046411684.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_046410844.1	1	Reactome: R-HSA-209968	"Thyroxine biosynthesis"
XP_046409771.1	12	Reactome: R-HSA-418885;KEGG: 04150+2.7.11.1;Reactome: R-HSA-416482;KEGG: 04151+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;Reactome: R-HSA-193648;Reactome: R-HSA-416476;Reactome: R-HSA-194840;KEGG: 04714+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1	"DCC mediated attractive signaling";"mTOR signaling pathway";"G alpha (12/13) signalling events";"PI3K-Akt signaling pathway";"Human cytomegalovirus infection";"Relaxin signaling pathway";"NRAGE signals death through JNK";"G alpha (q) signalling events";"Rho GTPase cycle";"Thermogenesis";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection"
XP_046417590.1	7	Reactome: R-HSA-500753;KEGG: 00240+2.4.2.10;MetaCyc: PWY-5686;MetaCyc: PWY-7791;KEGG: 00983+2.4.2.10;KEGG: 00240+4.1.1.23;MetaCyc: PWY-7790	"Pyrimidine biosynthesis";"Pyrimidine metabolism";"UMP biosynthesis I";"UMP biosynthesis III";"Drug metabolism - other enzymes";"Pyrimidine metabolism";"UMP biosynthesis II"
XP_046413730.1	2	Reactome: R-HSA-6782315;MetaCyc: PWY-6829	"tRNA modification in the nucleus and cytosol";"Trna methylation (yeast)"
XP_046422244.1	1	Reactome: R-HSA-606279	"Deposition of new CENPA-containing nucleosomes at the centromere"
XP_046428308.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046419772.1	1	Reactome: R-HSA-390522	"Striated Muscle Contraction"
XP_046423996.1	1	Reactome: R-HSA-901032	"ER Quality Control Compartment (ERQC)"
XP_046422629.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
XP_046423160.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_046424297.1	13	Reactome: R-HSA-156902;Reactome: R-HSA-975956;Reactome: R-HSA-72764;Reactome: R-HSA-975957;Reactome: R-HSA-6791226;Reactome: R-HSA-72706;Reactome: R-HSA-2408557;Reactome: R-HSA-1799339;Reactome: R-HSA-9633012;Reactome: R-HSA-72689;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-192823	"Peptide chain elongation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Selenocysteine synthesis";"SRP-dependent cotranslational protein targeting to membrane";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Formation of a pool of free 40S subunits";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Viral mRNA Translation"
XP_046416808.1	2	Reactome: R-HSA-8949664;Reactome: R-HSA-8949215	"Processing of SMDT1";"Mitochondrial calcium ion transport"
XP_046410504.1	7	Reactome: R-HSA-6784531;Reactome: R-HSA-1655829;Reactome: R-HSA-165054;Reactome: R-HSA-168333;Reactome: R-HSA-5578749;Reactome: R-HSA-180746;Reactome: R-HSA-203927	"tRNA processing in the nucleus";"Regulation of cholesterol biosynthesis by SREBP (SREBF)";"Rev-mediated nuclear export of HIV RNA";"NEP/NS2 Interacts with the Cellular Export Machinery";"Transcriptional regulation by small RNAs";"Nuclear import of Rev protein";"MicroRNA (miRNA) biogenesis"
XP_046415893.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046418546.1	4	Reactome: R-HSA-446199;Reactome: R-HSA-4755609;MetaCyc: PWY-6129;KEGG: 00900+2.5.1.87	"Synthesis of Dolichyl-phosphate";"Defective DHDDS causes retinitis pigmentosa 59";"Dolichol and dolichyl phosphate biosynthesis";"Terpenoid backbone biosynthesis"
XP_046432989.1	3	Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-212436	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"Generic Transcription Pathway"
XP_046423215.1	1	Reactome: R-HSA-4551638	"SUMOylation of chromatin organization proteins"
XP_046419335.1	4	Reactome: R-HSA-6794361;Reactome: R-HSA-8856828;Reactome: R-HSA-8856825;Reactome: R-HSA-5250958	"Neurexins and neuroligins";"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis";"Toxicity of botulinum toxin type B (BoNT/B)"
XP_046422088.1	3	Reactome: R-HSA-4420097;Reactome: R-HSA-2029482;Reactome: R-HSA-5663213	"VEGFA-VEGFR2 Pathway";"Regulation of actin dynamics for phagocytic cup formation";"RHO GTPases Activate WASPs and WAVEs"
XP_046427796.1	1	Reactome: R-HSA-196819	"Vitamin B1 (thiamin) metabolism"
XP_046421253.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046429298.1	1	Reactome: R-HSA-400253	"Circadian Clock"
XP_046412328.1	2	Reactome: R-HSA-8951664;Reactome: R-HSA-983168	"Neddylation";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046431090.1	4	MetaCyc: PWY-6482;Reactome: R-HSA-8849175;Reactome: R-HSA-5358493;MetaCyc: PWY-7546	"Diphthamide biosynthesis I (archaea)";"Threonine catabolism";"Synthesis of diphthamide-EEF2";"Diphthamide biosynthesis II (eukaryotes)"
XP_046428549.1	1	Reactome: R-HSA-389957	"Prefoldin mediated transfer of substrate to CCT/TriC"
XP_046424062.1	13	Reactome: R-HSA-1799339;Reactome: R-HSA-2408557;Reactome: R-HSA-72706;Reactome: R-HSA-192823;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-9633012;Reactome: R-HSA-72689;Reactome: R-HSA-72764;Reactome: R-HSA-975956;Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-975957	"SRP-dependent cotranslational protein targeting to membrane";"Selenocysteine synthesis";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Viral mRNA Translation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Formation of a pool of free 40S subunits";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
XP_046427495.1	2	Reactome: R-HSA-5576893;Reactome: R-HSA-5576892	"Phase 2 - plateau phase";"Phase 0 - rapid depolarisation"
XP_046429799.1	24	Reactome: R-HSA-1445148;Reactome: R-HSA-983189;Reactome: R-HSA-2500257;Reactome: R-HSA-9619483;Reactome: R-HSA-6807878;Reactome: R-HSA-5626467;Reactome: R-HSA-6811434;Reactome: R-HSA-9609690;Reactome: R-HSA-2467813;Reactome: R-HSA-9648025;Reactome: R-HSA-380320;Reactome: R-HSA-5663220;Reactome: R-HSA-437239;Reactome: R-HSA-3371497;Reactome: R-HSA-2132295;Reactome: R-HSA-5617833;Reactome: R-HSA-8852276;Reactome: R-HSA-68877;Reactome: R-HSA-190840;Reactome: R-HSA-190861;Reactome: R-HSA-9646399;Reactome: R-HSA-6811436;Reactome: R-HSA-8955332;Reactome: R-HSA-9609736	"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Kinesins";"Resolution of Sister Chromatid Cohesion";"Activation of AMPK downstream of NMDARs";"COPI-mediated anterograde transport";"RHO GTPases activate IQGAPs";"COPI-dependent Golgi-to-ER retrograde traffic";"HCMV Early Events";"Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation";"Recruitment of NuMA to mitotic centrosomes";"RHO GTPases Activate Formins";"Recycling pathway of L1";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"MHC class II antigen presentation";"Cilium Assembly";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Mitotic Prometaphase";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Gap junction assembly";"Aggrephagy";"COPI-independent Golgi-to-ER retrograde traffic";"Carboxyterminal post-translational modifications of tubulin";"Assembly and cell surface presentation of NMDA receptors"
XP_046412755.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046410049.1	5	MetaCyc: PWY-7863;KEGG: 00740+2.7.1.26;Reactome: R-HSA-196843;MetaCyc: PWY-5523;MetaCyc: PWY-6168	"Roseoflavin biosynthesis";"Riboflavin metabolism";"Vitamin B2 (riboflavin) metabolism";"5,6-dimethylbenzimidazole biosynthesis I (aerobic)";"Flavin biosynthesis III (fungi)"
XP_046422173.1	1	Reactome: R-HSA-5576886	"Phase 4 - resting membrane potential"
XP_046424424.1	2	Reactome: R-HSA-203927;Reactome: R-HSA-426486	"MicroRNA (miRNA) biogenesis";"Small interfering RNA (siRNA) biogenesis"
XP_046410887.1	3	KEGG: 00230+1.7.3.3;MetaCyc: PWY-5691;KEGG: 00232+1.7.3.3	"Purine metabolism";"Urate conversion to allantoin I";"Caffeine metabolism"
XP_046411561.1	1	Reactome: R-HSA-429947	"Deadenylation of mRNA"
XP_046419336.1	4	Reactome: R-HSA-5250958;Reactome: R-HSA-8856825;Reactome: R-HSA-8856828;Reactome: R-HSA-6794361	"Toxicity of botulinum toxin type B (BoNT/B)";"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis";"Neurexins and neuroligins"
XP_046433138.1	5	Reactome: R-HSA-2132295;Reactome: R-HSA-204005;Reactome: R-HSA-983170;Reactome: R-HSA-5694530;Reactome: R-HSA-1655829	"MHC class II antigen presentation";"COPII-mediated vesicle transport";"Antigen Presentation: Folding, assembly and peptide loading of class I MHC";"Cargo concentration in the ER";"Regulation of cholesterol biosynthesis by SREBP (SREBF)"
XP_046414164.1	1	Reactome: R-HSA-8849932	"Synaptic adhesion-like molecules"
XP_046412895.1	13	KEGG: 00982+2.5.1.18;MetaCyc: PWY-6370;MetaCyc: PWY-2261;MetaCyc: PWY-7112;MetaCyc: PWY-4061;KEGG: 00983+2.5.1.18;MetaCyc: PWY-6842;KEGG: 00480+2.5.1.18+1.8.5.1;KEGG: 00980+2.5.1.18;MetaCyc: PWY-7533;Reactome: R-HSA-196836;Reactome: R-HSA-156590;KEGG: 00053+1.8.5.1	"Drug metabolism - cytochrome P450";"Ascorbate recycling (cytosolic)";"Ascorbate glutathione cycle";"4-hydroxy-2-nonenal detoxification";"Glutathione-mediated detoxification I";"Drug metabolism - other enzymes";"Glutathione-mediated detoxification II";"Glutathione metabolism";"Metabolism of xenobiotics by cytochrome P450";"Gliotoxin biosynthesis";"Vitamin C (ascorbate) metabolism";"Glutathione conjugation";"Ascorbate and aldarate metabolism"
XP_046416108.1	5	Reactome: R-HSA-5693568;Reactome: R-HSA-5693579;Reactome: R-HSA-5685942;Reactome: R-HSA-5693554;Reactome: R-HSA-5693616	"Resolution of D-loop Structures through Holliday Junction Intermediates";"Homologous DNA Pairing and Strand Exchange";"HDR through Homologous Recombination (HRR)";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Presynaptic phase of homologous DNA pairing and strand exchange"
XP_046427676.1	1	Reactome: R-HSA-432047	"Passive transport by Aquaporins"
XP_046426762.1	2	MetaCyc: PWY-4261;KEGG: 00561+2.7.1.30	"Glycerol degradation I";"Glycerolipid metabolism"
XP_046430260.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_046424409.1	4	Reactome: R-HSA-351202;KEGG: 00480+2.5.1.16;KEGG: 00270+2.5.1.16;KEGG: 00330+2.5.1.16	"Metabolism of polyamines";"Glutathione metabolism";"Cysteine and methionine metabolism";"Arginine and proline metabolism"
XP_046414584.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046425080.1	1	Reactome: R-HSA-381753	"Olfactory Signaling Pathway"
XP_046427616.1	1	Reactome: R-HSA-72203	"Processing of Capped Intron-Containing Pre-mRNA"
XP_046412140.1	1	Reactome: R-HSA-9616222	"Transcriptional regulation of granulopoiesis"
XP_046431005.1	4	Reactome: R-HSA-180024;KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16	"DARPP-32 events";"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
XP_046416008.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_046428579.1	3	Reactome: R-HSA-416482;Reactome: R-HSA-194840;Reactome: R-HSA-193648	"G alpha (12/13) signalling events";"Rho GTPase cycle";"NRAGE signals death through JNK"
XP_046432824.1	3	Reactome: R-HSA-5576893;Reactome: R-HSA-5576890;Reactome: R-HSA-1296072	"Phase 2 - plateau phase";"Phase 3 - rapid repolarisation";"Voltage gated Potassium channels"
XP_046430916.1	5	Reactome: R-HSA-189451;MetaCyc: PWY-7159;MetaCyc: PWY-7766;KEGG: 00860+4.1.1.37;MetaCyc: PWY-5531	"Heme biosynthesis";"3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent)";"Heme b biosynthesis IV (Gram-positive bacteria)";"Porphyrin and chlorophyll metabolism";"3,8-divinyl-chlorophyllide a biosynthesis II (anaerobic)"
XP_046426113.1	2	Reactome: R-HSA-8949613;Reactome: R-HSA-163210	"Cristae formation";"Formation of ATP by chemiosmotic coupling"
XP_046409396.1	3	Reactome: R-HSA-196807;Reactome: R-HSA-73621;Reactome: R-HSA-74259	"Nicotinate metabolism";"Pyrimidine catabolism";"Purine catabolism"
XP_046427985.1	2	Reactome: R-HSA-5689603;Reactome: R-HSA-5689880	"UCH proteinases";"Ub-specific processing proteases"
XP_046421265.1	4	Reactome: R-HSA-8953750;Reactome: R-HSA-69202;Reactome: R-HSA-69656;Reactome: R-HSA-1362277	"Transcriptional Regulation by E2F6";"Cyclin E associated events during G1/S transition";"Cyclin A:Cdk2-associated events at S phase entry";"Transcription of E2F targets under negative control by DREAM complex"
XP_046429674.1	15	Reactome: R-HSA-9018519;Reactome: R-HSA-8934593;Reactome: R-HSA-8936459;Reactome: R-HSA-8943723;Reactome: R-HSA-1912408;Reactome: R-HSA-8986944;Reactome: R-HSA-4086398;Reactome: R-HSA-2559585;Reactome: R-HSA-8948700;Reactome: R-HSA-5628897;Reactome: R-HSA-9022692;Reactome: R-HSA-8853884;Reactome: R-HSA-5687128;Reactome: R-HSA-9029569;Reactome: R-HSA-2559580	"Estrogen-dependent gene expression";"Regulation of RUNX1 Expression and Activity";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Regulation of PTEN mRNA translation";"Pre-NOTCH Transcription and Translation";"Transcriptional Regulation by MECP2";"Ca2+ pathway";"Oncogene Induced Senescence";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"TP53 Regulates Metabolic Genes";"Regulation of MECP2 expression and activity";"Transcriptional Regulation by VENTX";"MAPK6/MAPK4 signaling";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Oxidative Stress Induced Senescence"
XP_046432846.1	3	Reactome: R-HSA-5696394;Reactome: R-HSA-3108214;Reactome: R-HSA-5696395	"DNA Damage Recognition in GG-NER";"SUMOylation of DNA damage response and repair proteins";"Formation of Incision Complex in GG-NER"
XP_046430408.1	27	Reactome: R-HSA-168276;Reactome: R-HSA-3301854;Reactome: R-HSA-5619107;Reactome: R-HSA-180746;Reactome: R-HSA-159230;Reactome: R-HSA-5578749;Reactome: R-HSA-191859;Reactome: R-HSA-4615885;Reactome: R-HSA-168271;Reactome: R-HSA-159227;Reactome: R-HSA-168333;Reactome: R-HSA-4570464;Reactome: R-HSA-9610379;Reactome: R-HSA-159236;Reactome: R-HSA-9609690;Reactome: R-HSA-3108214;Reactome: R-HSA-159231;Reactome: R-HSA-1169408;Reactome: R-HSA-168325;Reactome: R-HSA-170822;Reactome: R-HSA-3232142;Reactome: R-HSA-3371453;Reactome: R-HSA-180910;Reactome: R-HSA-4551638;Reactome: R-HSA-165054;Reactome: R-HSA-6784531;Reactome: R-HSA-4085377	"NS1 Mediated Effects on Host Pathways";"Nuclear Pore Complex (NPC) Disassembly";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Nuclear import of Rev protein";"Transport of the SLBP Dependant Mature mRNA";"Transcriptional regulation by small RNAs";"snRNP Assembly";"SUMOylation of DNA replication proteins";"Transport of Ribonucleoproteins into the Host Nucleus";"Transport of the SLBP independent Mature mRNA";"NEP/NS2 Interacts with the Cellular Export Machinery";"SUMOylation of RNA binding proteins";"HCMV Late Events";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"HCMV Early Events";"SUMOylation of DNA damage response and repair proteins";"Transport of Mature mRNA Derived from an Intronless Transcript";"ISG15 antiviral mechanism";"Viral Messenger RNA Synthesis";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"SUMOylation of ubiquitinylation proteins";"Regulation of HSF1-mediated heat shock response";"Vpr-mediated nuclear import of PICs";"SUMOylation of chromatin organization proteins";"Rev-mediated nuclear export of HIV RNA";"tRNA processing in the nucleus";"SUMOylation of SUMOylation proteins"
XP_046417980.1	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
XP_046409756.1	1	Reactome: R-HSA-6803157	"Antimicrobial peptides"
XP_046430808.1	5	Reactome: R-HSA-3214815;Reactome: R-HSA-8943724;Reactome: R-HSA-73762;Reactome: R-HSA-427389;Reactome: R-HSA-6804758	"HDACs deacetylate histones";"Regulation of PTEN gene transcription";"RNA Polymerase I Transcription Initiation";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"Regulation of TP53 Activity through Acetylation"
XP_046414743.1	1	Reactome: R-HSA-425986	"Sodium/Proton exchangers"
XP_046430513.1	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
XP_046432021.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_046425127.1	1	Reactome: R-HSA-975957	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
XP_046426785.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_046419005.1	2	Reactome: R-HSA-5357956;Reactome: R-HSA-5357905	"TNFR1-induced NFkappaB signaling pathway";"Regulation of TNFR1 signaling"
XP_046415457.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_046430827.1	1	Reactome: R-HSA-203927	"MicroRNA (miRNA) biogenesis"
XP_046421252.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046431323.1	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
XP_046422759.1	3	Reactome: R-HSA-204174;Reactome: R-HSA-156590;Reactome: R-HSA-8963684	"Regulation of pyruvate dehydrogenase (PDH) complex";"Glutathione conjugation";"Tyrosine catabolism"
XP_046426288.1	2	Reactome: R-HSA-73980;Reactome: R-HSA-749476	"RNA Polymerase III Transcription Termination";"RNA Polymerase III Abortive And Retractive Initiation"
XP_046436580.1	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046419322.1	1	Reactome: R-HSA-5693565	"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"
XP_046412672.1	7	Reactome: R-HSA-5620912;Reactome: R-HSA-380284;Reactome: R-HSA-380270;Reactome: R-HSA-2565942;Reactome: R-HSA-380320;Reactome: R-HSA-380259;Reactome: R-HSA-8854518	"Anchoring of the basal body to the plasma membrane";"Loss of proteins required for interphase microtubule organization from the centrosome";"Recruitment of mitotic centrosome proteins and complexes";"Regulation of PLK1 Activity at G2/M Transition";"Recruitment of NuMA to mitotic centrosomes";"Loss of Nlp from mitotic centrosomes";"AURKA Activation by TPX2"
XP_046411087.1	3	Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-9018519	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"Estrogen-dependent gene expression"
XP_046421194.1	1	Reactome: R-HSA-5693607	"Processing of DNA double-strand break ends"
XP_046423667.1	1	Reactome: R-HSA-196843	"Vitamin B2 (riboflavin) metabolism"
XP_046435107.1	4	Reactome: R-HSA-5661270;MetaCyc: PWY-4261;KEGG: 00040+2.7.1.17;KEGG: 00561+2.7.1.30	"Formation of xylulose-5-phosphate";"Glycerol degradation I";"Pentose and glucuronate interconversions";"Glycerolipid metabolism"
XP_046424040.1	1	Reactome: R-HSA-2022928	"HS-GAG biosynthesis"
XP_046423403.1	11	Reactome: R-HSA-167172;Reactome: R-HSA-167162;Reactome: R-HSA-5689880;Reactome: R-HSA-76042;Reactome: R-HSA-75953;Reactome: R-HSA-6804756;Reactome: R-HSA-167161;Reactome: R-HSA-3214847;Reactome: R-HSA-73779;Reactome: R-HSA-674695;Reactome: R-HSA-73776	"Transcription of the HIV genome";"RNA Polymerase II HIV Promoter Escape";"Ub-specific processing proteases";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II Transcription Initiation";"Regulation of TP53 Activity through Phosphorylation";"HIV Transcription Initiation";"HATs acetylate histones";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Promoter Escape"
XP_046414413.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046431091.1	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
XP_046424015.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_046421576.1	7	KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1	"Thermogenesis";"Human cytomegalovirus infection";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Relaxin signaling pathway";"mTOR signaling pathway";"PI3K-Akt signaling pathway"
XP_046431418.1	3	KEGG: 00230+4.6.1.2;Reactome: R-HSA-445355;Reactome: R-HSA-392154	"Purine metabolism";"Smooth Muscle Contraction";"Nitric oxide stimulates guanylate cyclase"
XP_046431807.1	2	Reactome: R-HSA-429947;Reactome: R-HSA-6804115	"Deadenylation of mRNA";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"
XP_046432723.1	6	Reactome: R-HSA-975578;MetaCyc: PWY-7920;KEGG: 00513+2.4.1.143;KEGG: 00510+2.4.1.143;MetaCyc: PWY-7426;Reactome: R-HSA-4793952	"Reactions specific to the complex N-glycan synthesis pathway";"Complex N-linked glycan biosynthesis (plants)";"Various types of N-glycan biosynthesis";"N-Glycan biosynthesis";"Complex N-linked glycan biosynthesis (vertebrates)";"Defective MGAT2 causes MGAT2-CDG (CDG-2a)"
XP_046424187.1	12	KEGG: 00052+2.7.7.9;KEGG: 00520+2.7.7.9;MetaCyc: PWY-7343;MetaCyc: PWY-7817;MetaCyc: PWY-7238;Reactome: R-HSA-3322077;KEGG: 00500+2.7.7.9;KEGG: 00561+2.7.7.9;MetaCyc: PWY-3801;Reactome: R-HSA-173599;MetaCyc: PWY-6527;KEGG: 00040+2.7.7.9	"Galactose metabolism";"Amino sugar and nucleotide sugar metabolism";"UDP-alpha-D-glucose biosynthesis I";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Sucrose biosynthesis II";"Glycogen synthesis";"Starch and sucrose metabolism";"Glycerolipid metabolism";"Sucrose degradation II (sucrose synthase)";"Formation of the active cofactor, UDP-glucuronate";"Stachyose degradation";"Pentose and glucuronate interconversions"
XP_046425014.1	2	Reactome: R-HSA-5689896;Reactome: R-HSA-936440	"Ovarian tumor domain proteases";"Negative regulators of DDX58/IFIH1 signaling"
XP_046412329.1	2	KEGG: 00510+3.6.1.43;Reactome: R-HSA-446199	"N-Glycan biosynthesis";"Synthesis of Dolichyl-phosphate"
XP_046414589.1	2	Reactome: R-HSA-8876198;Reactome: R-HSA-8873719	"RAB GEFs exchange GTP for GDP on RABs";"RAB geranylgeranylation"
XP_046432876.1	27	Reactome: R-HSA-159230;Reactome: R-HSA-5578749;Reactome: R-HSA-180746;Reactome: R-HSA-191859;Reactome: R-HSA-4615885;Reactome: R-HSA-168276;Reactome: R-HSA-3301854;Reactome: R-HSA-5619107;Reactome: R-HSA-159227;Reactome: R-HSA-168333;Reactome: R-HSA-168271;Reactome: R-HSA-159236;Reactome: R-HSA-9609690;Reactome: R-HSA-159231;Reactome: R-HSA-3108214;Reactome: R-HSA-168325;Reactome: R-HSA-1169408;Reactome: R-HSA-4570464;Reactome: R-HSA-9610379;Reactome: R-HSA-4551638;Reactome: R-HSA-4085377;Reactome: R-HSA-6784531;Reactome: R-HSA-165054;Reactome: R-HSA-170822;Reactome: R-HSA-3232142;Reactome: R-HSA-180910;Reactome: R-HSA-3371453	"Transport of the SLBP Dependant Mature mRNA";"Transcriptional regulation by small RNAs";"Nuclear import of Rev protein";"snRNP Assembly";"SUMOylation of DNA replication proteins";"NS1 Mediated Effects on Host Pathways";"Nuclear Pore Complex (NPC) Disassembly";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Transport of the SLBP independent Mature mRNA";"NEP/NS2 Interacts with the Cellular Export Machinery";"Transport of Ribonucleoproteins into the Host Nucleus";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"HCMV Early Events";"Transport of Mature mRNA Derived from an Intronless Transcript";"SUMOylation of DNA damage response and repair proteins";"Viral Messenger RNA Synthesis";"ISG15 antiviral mechanism";"SUMOylation of RNA binding proteins";"HCMV Late Events";"SUMOylation of chromatin organization proteins";"SUMOylation of SUMOylation proteins";"tRNA processing in the nucleus";"Rev-mediated nuclear export of HIV RNA";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"SUMOylation of ubiquitinylation proteins";"Vpr-mediated nuclear import of PICs";"Regulation of HSF1-mediated heat shock response"
XP_046419029.1	2	Reactome: R-HSA-1433557;KEGG: 04660+2.7.10.2	"Signaling by SCF-KIT";"T cell receptor signaling pathway"
XP_046412521.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_046419802.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046421495.1	2	Reactome: R-HSA-8856825;Reactome: R-HSA-8856828	"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis"
XP_046431292.1	1	Reactome: R-HSA-426117	"Cation-coupled Chloride cotransporters"
XP_046411871.1	11	Reactome: R-HSA-205043;Reactome: R-HSA-3928665;Reactome: R-HSA-2644606;Reactome: R-HSA-2979096;Reactome: R-HSA-9017802;Reactome: R-HSA-193692;Reactome: R-HSA-1251985;Reactome: R-HSA-9013507;Reactome: R-HSA-2122948;Reactome: R-HSA-2894862;Reactome: R-HSA-9013700	"NRIF signals cell death from the nucleus";"EPH-ephrin mediated repulsion of cells";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Noncanonical activation of NOTCH3";"Regulated proteolysis of p75NTR";"Nuclear signaling by ERBB4";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Activated NOTCH1 Transmits Signal to the Nucleus";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"NOTCH4 Activation and Transmission of Signal to the Nucleus"
XP_046414619.1	7	KEGG: 00400+1.14.16.1;MetaCyc: PWY-6134;MetaCyc: PWY-7158;KEGG: 00360+1.14.16.1;Reactome: R-HSA-2160456;Reactome: R-HSA-8964208;KEGG: 00790+1.14.16.1	"Phenylalanine, tyrosine and tryptophan biosynthesis";"L-tyrosine biosynthesis IV";"L-phenylalanine degradation V";"Phenylalanine metabolism";"Phenylketonuria";"Phenylalanine metabolism";"Folate biosynthesis"
XP_046421267.1	4	Reactome: R-HSA-1362277;Reactome: R-HSA-69656;Reactome: R-HSA-69202;Reactome: R-HSA-8953750	"Transcription of E2F targets under negative control by DREAM complex";"Cyclin A:Cdk2-associated events at S phase entry";"Cyclin E associated events during G1/S transition";"Transcriptional Regulation by E2F6"
XP_046433937.1	3	KEGG: 00790+4.1.99.22;MetaCyc: PWY-6823;Reactome: R-HSA-947581	"Folate biosynthesis";"Molybdenum cofactor biosynthesis";"Molybdenum cofactor biosynthesis"
XP_046430727.1	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286	"Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation"
XP_046435034.1	5	Reactome: R-HSA-2132295;Reactome: R-HSA-204005;Reactome: R-HSA-983170;Reactome: R-HSA-5694530;Reactome: R-HSA-1655829	"MHC class II antigen presentation";"COPII-mediated vesicle transport";"Antigen Presentation: Folding, assembly and peptide loading of class I MHC";"Cargo concentration in the ER";"Regulation of cholesterol biosynthesis by SREBP (SREBF)"
XP_046415096.1	1	MetaCyc: PWY-6308	"L-cysteine biosynthesis II (tRNA-dependent)"
XP_046412325.1	2	Reactome: R-HSA-983168;Reactome: R-HSA-8951664	"Antigen processing: Ubiquitination & Proteasome degradation";"Neddylation"
XP_046416523.1	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
XP_046418491.1	4	Reactome: R-HSA-76071;Reactome: R-HSA-749476;Reactome: R-HSA-76066;Reactome: R-HSA-76061	"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Transcription Initiation From Type 1 Promoter"
XP_046417606.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046435167.1	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
XP_046412847.1	2	KEGG: 00071+2.3.1.21;MetaCyc: PWY-6111	"Fatty acid degradation";"Mitochondrial L-carnitine shuttle"
XP_046434945.1	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
XP_046436693.1	12	Reactome: R-HSA-2500257;Reactome: R-HSA-5663220;Reactome: R-HSA-6807878;Reactome: R-HSA-3371497;Reactome: R-HSA-2132295;Reactome: R-HSA-2467813;Reactome: R-HSA-9646399;Reactome: R-HSA-6811436;Reactome: R-HSA-9609690;Reactome: R-HSA-68877;Reactome: R-HSA-141444;Reactome: R-HSA-9648025	"Resolution of Sister Chromatid Cohesion";"RHO GTPases Activate Formins";"COPI-mediated anterograde transport";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"MHC class II antigen presentation";"Separation of Sister Chromatids";"Aggrephagy";"COPI-independent Golgi-to-ER retrograde traffic";"HCMV Early Events";"Mitotic Prometaphase";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"EML4 and NUDC in mitotic spindle formation"
XP_046412311.1	4	MetaCyc: PWY-6483;MetaCyc: PWY-7119;Reactome: R-HSA-1660662;KEGG: 00600+3.5.1.23	"Ceramide degradation (generic)";"Ceramide and sphingolipid recycling and degradation (yeast)";"Glycosphingolipid metabolism";"Sphingolipid metabolism"
XP_046421264.1	4	Reactome: R-HSA-8953750;Reactome: R-HSA-69202;Reactome: R-HSA-69656;Reactome: R-HSA-1362277	"Transcriptional Regulation by E2F6";"Cyclin E associated events during G1/S transition";"Cyclin A:Cdk2-associated events at S phase entry";"Transcription of E2F targets under negative control by DREAM complex"
XP_046434992.1	1	Reactome: R-HSA-426048	"Arachidonate production from DAG"
XP_046425174.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_046418012.1	4	Reactome: R-HSA-5362768;Reactome: R-HSA-5678895;Reactome: R-HSA-5358346;Reactome: R-HSA-382556	"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Defective CFTR causes cystic fibrosis";"Hedgehog ligand biogenesis";"ABC-family proteins mediated transport"
XP_046426796.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_046430791.1	1	Reactome: R-HSA-6794361	"Neurexins and neuroligins"
XP_046423130.1	3	Reactome: R-HSA-6784531;Reactome: R-HSA-8868766;Reactome: R-HSA-6785470	"tRNA processing in the nucleus";"rRNA processing in the mitochondrion";"tRNA processing in the mitochondrion"
XP_046421635.1	3	KEGG: 04070+2.7.4.24+2.7.4.21;MetaCyc: PWY-6369;Reactome: R-HSA-1855167	"Phosphatidylinositol signaling system";"Inositol diphosphates biosynthesis";"Synthesis of pyrophosphates in the cytosol"
XP_046420713.1	14	MetaCyc: PWY-6598;MetaCyc: PWY-7602;MetaCyc: PWY-7036;MetaCyc: PWY-8041;MetaCyc: PWY-7035;MetaCyc: PWY-7725;MetaCyc: PWY-7619;MetaCyc: PWY-7601;KEGG: 00062+2.3.1.199;MetaCyc: PWY-5080;Reactome: R-HSA-75876;MetaCyc: PWY-5972;MetaCyc: PWY-7724;MetaCyc: PWY-6433	"Sciadonate biosynthesis";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis II";"Ultra-long-chain fatty acid biosynthesis";"(9Z)-tricosene biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Juniperonate biosynthesis";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Fatty acid elongation";"Very long chain fatty acid biosynthesis I";"Synthesis of very long-chain fatty acyl-CoAs";"Stearate biosynthesis I (animals)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Hydroxylated fatty acid biosynthesis (plants)"
XP_046434251.1	1	Reactome: R-HSA-373080	"Class B/2 (Secretin family receptors)"
XP_046429519.1	1	Reactome: R-HSA-419771	"Opsins"
XP_046427082.1	1	Reactome: R-HSA-8964038	"LDL clearance"
XP_046413677.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_046431401.1	2	Reactome: R-HSA-9033241;Reactome: R-HSA-9033500	"Peroxisomal protein import";"TYSND1 cleaves peroxisomal proteins"
XP_046412892.1	13	KEGG: 00982+2.5.1.18;MetaCyc: PWY-6370;MetaCyc: PWY-4061;MetaCyc: PWY-7112;KEGG: 00983+2.5.1.18;MetaCyc: PWY-2261;KEGG: 00980+2.5.1.18;MetaCyc: PWY-6842;KEGG: 00480+2.5.1.18+1.8.5.1;Reactome: R-HSA-156590;KEGG: 00053+1.8.5.1;Reactome: R-HSA-196836;MetaCyc: PWY-7533	"Drug metabolism - cytochrome P450";"Ascorbate recycling (cytosolic)";"Glutathione-mediated detoxification I";"4-hydroxy-2-nonenal detoxification";"Drug metabolism - other enzymes";"Ascorbate glutathione cycle";"Metabolism of xenobiotics by cytochrome P450";"Glutathione-mediated detoxification II";"Glutathione metabolism";"Glutathione conjugation";"Ascorbate and aldarate metabolism";"Vitamin C (ascorbate) metabolism";"Gliotoxin biosynthesis"
XP_046427980.1	14	Reactome: R-HSA-8943723;Reactome: R-HSA-1912408;Reactome: R-HSA-4086398;Reactome: R-HSA-8986944;Reactome: R-HSA-5628897;Reactome: R-HSA-8948700;Reactome: R-HSA-9018519;Reactome: R-HSA-8934593;Reactome: R-HSA-426486;Reactome: R-HSA-426496;Reactome: R-HSA-9029569;Reactome: R-HSA-9022692;Reactome: R-HSA-203927;Reactome: R-HSA-5687128	"Regulation of PTEN mRNA translation";"Pre-NOTCH Transcription and Translation";"Ca2+ pathway";"Transcriptional Regulation by MECP2";"TP53 Regulates Metabolic Genes";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"Estrogen-dependent gene expression";"Regulation of RUNX1 Expression and Activity";"Small interfering RNA (siRNA) biogenesis";"Post-transcriptional silencing by small RNAs";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Regulation of MECP2 expression and activity";"MicroRNA (miRNA) biogenesis";"MAPK6/MAPK4 signaling"
XP_046432860.1	1	Reactome: R-HSA-1614635	"Sulfur amino acid metabolism"
XP_046425169.1	9	Reactome: R-HSA-1362300;Reactome: R-HSA-2173796;Reactome: R-HSA-69205;Reactome: R-HSA-1362277;Reactome: R-HSA-1538133;Reactome: R-HSA-69231;Reactome: R-HSA-69202;Reactome: R-HSA-69656;Reactome: R-HSA-6804114	"Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"G1/S-Specific Transcription";"Transcription of E2F targets under negative control by DREAM complex";"G0 and Early G1";"Cyclin D associated events in G1";"Cyclin E associated events during G1/S transition";"Cyclin A:Cdk2-associated events at S phase entry";"TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest"
XP_046429921.1	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
XP_046418945.1	9	MetaCyc: PWY-5789;MetaCyc: PWY-6142;MetaCyc: PWY-241;Reactome: R-HSA-1475029;KEGG: 00910+4.2.1.1;MetaCyc: PWY-7115;MetaCyc: PWY-5743;MetaCyc: PWY-5744;MetaCyc: PWY-7117	"3-hydroxypropanoate/4-hydroxybutanate cycle";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"C4 photosynthetic carbon assimilation cycle, NADP-ME type";"Reversible hydration of carbon dioxide";"Nitrogen metabolism";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"3-hydroxypropanoate cycle";"Glyoxylate assimilation";"C4 photosynthetic carbon assimilation cycle, PEPCK type"
XP_046432134.1	3	MetaCyc: PWY-5491;KEGG: 00790+3.1.3.1;KEGG: 00730+3.1.3.1	"Diethylphosphate degradation";"Folate biosynthesis";"Thiamine metabolism"
XP_046412858.1	2	MetaCyc: PWY-7221;KEGG: 00230+2.7.4.8	"Guanosine ribonucleotides de novo biosynthesis";"Purine metabolism"
XP_046413897.1	1	KEGG: 00970+6.1.1.2	"Aminoacyl-tRNA biosynthesis"
XP_046435442.1	6	Reactome: R-HSA-975957;Reactome: R-HSA-72163;Reactome: R-HSA-159236;Reactome: R-HSA-9010553;Reactome: R-HSA-72187;Reactome: R-HSA-73856	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"mRNA Splicing - Major Pathway";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Regulation of expression of SLITs and ROBOs";"mRNA 3'-end processing";"RNA Polymerase II Transcription Termination"
XP_046413539.1	2	KEGG: 00500+3.2.1.28;Reactome: R-HSA-189085	"Starch and sucrose metabolism";"Digestion of dietary carbohydrate"
XP_046426199.1	2	Reactome: R-HSA-2514853;Reactome: R-HSA-2299718	"Condensation of Prometaphase Chromosomes";"Condensation of Prophase Chromosomes"
XP_046433250.1	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046427597.1	1	Reactome: R-HSA-72203	"Processing of Capped Intron-Containing Pre-mRNA"
XP_046409319.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_046410738.1	2	Reactome: R-HSA-8849175;KEGG: 00260+2.3.1.29	"Threonine catabolism";"Glycine, serine and threonine metabolism"
XP_046424293.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-5628897	"Respiratory electron transport";"TP53 Regulates Metabolic Genes"
XP_046430771.1	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
XP_046417110.1	3	Reactome: R-HSA-4420097;Reactome: R-HSA-2029482;Reactome: R-HSA-5663213	"VEGFA-VEGFR2 Pathway";"Regulation of actin dynamics for phagocytic cup formation";"RHO GTPases Activate WASPs and WAVEs"
XP_046409343.1	1	KEGG: 04070+2.7.11.13	"Phosphatidylinositol signaling system"
XP_046418525.1	4	Reactome: R-HSA-1632852;Reactome: R-HSA-5205685;Reactome: R-HSA-8934903;Reactome: R-HSA-936440	"Macroautophagy";"Pink/Parkin Mediated Mitophagy";"Receptor Mediated Mitophagy";"Negative regulators of DDX58/IFIH1 signaling"
XP_046423202.1	1	Reactome: R-HSA-418886	"Netrin mediated repulsion signals"
XP_046434370.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_046424538.1	3	MetaCyc: PWY-7511;Reactome: R-HSA-983168;Reactome: R-HSA-6783310	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation";"Fanconi Anemia Pathway"
XP_046431074.1	4	Reactome: R-HSA-3769402;Reactome: R-HSA-4641265;Reactome: R-HSA-201722;Reactome: R-HSA-2122947	"Deactivation of the beta-catenin transactivating complex";"Repression of WNT target genes";"Formation of the beta-catenin:TCF transactivating complex";"NOTCH1 Intracellular Domain Regulates Transcription"
XP_046420121.1	6	Reactome: R-HSA-68867;Reactome: R-HSA-176974;Reactome: R-HSA-176187;Reactome: R-HSA-69052;Reactome: R-HSA-68962;Reactome: R-HSA-68949	"Assembly of the pre-replicative complex";"Unwinding of DNA";"Activation of ATR in response to replication stress";"Switching of origins to a post-replicative state";"Activation of the pre-replicative complex";"Orc1 removal from chromatin"
XP_046424491.1	10	Reactome: R-HSA-76042;Reactome: R-HSA-75953;Reactome: R-HSA-167162;Reactome: R-HSA-167172;Reactome: R-HSA-73776;Reactome: R-HSA-674695;Reactome: R-HSA-73779;Reactome: R-HSA-3214847;Reactome: R-HSA-6804756;Reactome: R-HSA-167161	"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II HIV Promoter Escape";"Transcription of the HIV genome";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"HATs acetylate histones";"Regulation of TP53 Activity through Phosphorylation";"HIV Transcription Initiation"
XP_046435150.1	7	Reactome: R-HSA-380259;Reactome: R-HSA-8854518;Reactome: R-HSA-2565942;Reactome: R-HSA-380270;Reactome: R-HSA-380320;Reactome: R-HSA-380284;Reactome: R-HSA-5620912	"Loss of Nlp from mitotic centrosomes";"AURKA Activation by TPX2";"Regulation of PLK1 Activity at G2/M Transition";"Recruitment of mitotic centrosome proteins and complexes";"Recruitment of NuMA to mitotic centrosomes";"Loss of proteins required for interphase microtubule organization from the centrosome";"Anchoring of the basal body to the plasma membrane"
XP_046433466.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_046409300.1	3	MetaCyc: PWY-6619;KEGG: 00230+2.7.1.20;Reactome: R-HSA-74217	"Adenine and adenosine salvage VI";"Purine metabolism";"Purine salvage"
XP_046432692.1	2	Reactome: R-HSA-445095;Reactome: R-HSA-5576892	"Interaction between L1 and Ankyrins";"Phase 0 - rapid depolarisation"
XP_046419267.1	1	Reactome: R-HSA-6784531	"tRNA processing in the nucleus"
XP_046421641.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046410173.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_046423238.1	10	Reactome: R-HSA-5693568;Reactome: R-HSA-5693579;Reactome: R-HSA-5685942;Reactome: R-HSA-5693607;Reactome: R-HSA-912446;Reactome: R-HSA-6804756;Reactome: R-HSA-69473;Reactome: R-HSA-5685938;Reactome: R-HSA-5693616;Reactome: R-HSA-5693554	"Resolution of D-loop Structures through Holliday Junction Intermediates";"Homologous DNA Pairing and Strand Exchange";"HDR through Homologous Recombination (HRR)";"Processing of DNA double-strand break ends";"Meiotic recombination";"Regulation of TP53 Activity through Phosphorylation";"G2/M DNA damage checkpoint";"HDR through Single Strand Annealing (SSA)";"Presynaptic phase of homologous DNA pairing and strand exchange";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)"
XP_046417755.1	11	Reactome: R-HSA-174437;Reactome: R-HSA-5693568;Reactome: R-HSA-5693579;Reactome: R-HSA-5685942;Reactome: R-HSA-5693607;Reactome: R-HSA-69166;Reactome: R-HSA-6804756;Reactome: R-HSA-69473;Reactome: R-HSA-5685938;Reactome: R-HSA-5693554;Reactome: R-HSA-5693616	"Removal of the Flap Intermediate from the C-strand";"Resolution of D-loop Structures through Holliday Junction Intermediates";"Homologous DNA Pairing and Strand Exchange";"HDR through Homologous Recombination (HRR)";"Processing of DNA double-strand break ends";"Removal of the Flap Intermediate";"Regulation of TP53 Activity through Phosphorylation";"G2/M DNA damage checkpoint";"HDR through Single Strand Annealing (SSA)";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Presynaptic phase of homologous DNA pairing and strand exchange"
XP_046412897.1	1	Reactome: R-HSA-611105	"Respiratory electron transport"
XP_046411331.1	4	MetaCyc: PWY-6030;KEGG: 00790+1.14.16.4;Reactome: R-HSA-209931;KEGG: 00380+1.14.16.4	"Serotonin and melatonin biosynthesis";"Folate biosynthesis";"Serotonin and melatonin biosynthesis";"Tryptophan metabolism"
XP_046415404.1	1	Reactome: R-HSA-114608	"Platelet degranulation"
XP_046419413.1	7	Reactome: R-HSA-77111;Reactome: R-HSA-9033241;MetaCyc: PWY-5074;KEGG: 00072+4.1.3.4;KEGG: 00280+4.1.3.4;KEGG: 00650+4.1.3.4;KEGG: 00281+4.1.3.4	"Synthesis of Ketone Bodies";"Peroxisomal protein import";"Mevalonate degradation";"Synthesis and degradation of ketone bodies";"Valine, leucine and isoleucine degradation";"Butanoate metabolism";"Geraniol degradation"
XP_046429701.1	3	Reactome: R-HSA-212436;Reactome: R-HSA-381340;Reactome: R-HSA-1989781	"Generic Transcription Pathway";"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression"
XP_046417196.1	32	Reactome: R-HSA-167172;Reactome: R-HSA-674695;Reactome: R-HSA-167242;Reactome: R-HSA-6796648;Reactome: R-HSA-77075;Reactome: R-HSA-167200;Reactome: R-HSA-167290;Reactome: R-HSA-167152;Reactome: R-HSA-6803529;Reactome: R-HSA-75953;Reactome: R-HSA-167246;Reactome: R-HSA-72165;Reactome: R-HSA-167238;Reactome: R-HSA-73779;Reactome: R-HSA-167160;Reactome: R-HSA-76042;Reactome: R-HSA-72203;Reactome: R-HSA-75955;Reactome: R-HSA-112382;Reactome: R-HSA-72163;Reactome: R-HSA-167243;Reactome: R-HSA-72086;Reactome: R-HSA-73776;Reactome: R-HSA-168325;Reactome: R-HSA-167161;Reactome: R-HSA-8851708;Reactome: R-HSA-9018519;Reactome: R-HSA-6807505;Reactome: R-HSA-167162;Reactome: R-HSA-113418;Reactome: R-HSA-167158;Reactome: R-HSA-167287	"Transcription of the HIV genome";"RNA Polymerase II Pre-transcription Events";"Abortive elongation of HIV-1 transcript in the absence of Tat";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Pol II CTD phosphorylation and interaction with CE";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Pausing and recovery of HIV elongation";"Formation of HIV elongation complex in the absence of HIV Tat";"FGFR2 alternative splicing";"RNA Polymerase II Transcription Initiation";"Tat-mediated elongation of the HIV-1 transcript";"mRNA Splicing - Minor Pathway";"Pausing and recovery of Tat-mediated HIV elongation";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Processing of Capped Intron-Containing Pre-mRNA";"RNA Polymerase II Transcription Elongation";"Formation of RNA Pol II elongation complex";"mRNA Splicing - Major Pathway";"Tat-mediated HIV elongation arrest and recovery";"mRNA Capping";"RNA Polymerase II Promoter Escape";"Viral Messenger RNA Synthesis";"HIV Transcription Initiation";"Signaling by FGFR2 IIIa TM";"Estrogen-dependent gene expression";"RNA polymerase II transcribes snRNA genes";"RNA Polymerase II HIV Promoter Escape";"Formation of the Early Elongation Complex";"Formation of the HIV-1 Early Elongation Complex";"HIV elongation arrest and recovery"
XP_046409327.1	1	Reactome: R-HSA-1614558	"Degradation of cysteine and homocysteine"
XP_046425532.1	13	KEGG: 00230+1.17.4.1;KEGG: 00480+1.17.4.1;MetaCyc: PWY-7226;MetaCyc: PWY-7198;MetaCyc: PWY-7227;MetaCyc: PWY-7220;KEGG: 00983+1.17.4.1;MetaCyc: PWY-7222;KEGG: 00240+1.17.4.1;MetaCyc: PWY-6545;Reactome: R-HSA-499943;MetaCyc: PWY-7210;MetaCyc: PWY-7184	"Purine metabolism";"Glutathione metabolism";"Guanosine deoxyribonucleotides de novo biosynthesis I";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Adenosine deoxyribonucleotides de novo biosynthesis";"Adenosine deoxyribonucleotides de novo biosynthesis II";"Drug metabolism - other enzymes";"Guanosine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Interconversion of nucleotide di- and triphosphates";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Pyrimidine deoxyribonucleotides de novo biosynthesis I"
XP_046410172.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_046435373.1	2	Reactome: R-HSA-8856825;Reactome: R-HSA-8856828	"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis"
XP_046428356.1	57	Reactome: R-HSA-8939236;Reactome: R-HSA-5610785;Reactome: R-HSA-5678895;Reactome: R-HSA-180585;Reactome: R-HSA-202424;Reactome: R-HSA-75815;Reactome: R-HSA-4641257;Reactome: R-HSA-4608870;Reactome: R-HSA-1236978;Reactome: R-HSA-349425;Reactome: R-HSA-5689880;Reactome: R-HSA-8951664;Reactome: R-HSA-174084;Reactome: R-HSA-2467813;Reactome: R-HSA-8939902;Reactome: R-HSA-174184;Reactome: R-HSA-174154;Reactome: R-HSA-6798695;Reactome: R-HSA-983168;Reactome: R-HSA-5658442;Reactome: R-HSA-5607761;Reactome: R-HSA-5610783;Reactome: R-HSA-8852276;Reactome: R-HSA-69481;Reactome: R-HSA-8948751;Reactome: R-HSA-1234176;Reactome: R-HSA-180534;Reactome: R-HSA-187577;Reactome: R-HSA-5607764;Reactome: R-HSA-68827;Reactome: R-HSA-5689603;Reactome: R-HSA-5687128;Reactome: R-HSA-174113;Reactome: R-HSA-8854050;Reactome: R-HSA-9020702;Reactome: R-HSA-195253;Reactome: R-HSA-2871837;Reactome: R-HSA-174178;Reactome: R-HSA-1169091;Reactome: R-HSA-68949;Reactome: R-HSA-382556;Reactome: R-HSA-5676590;Reactome: R-HSA-9604323;Reactome: R-HSA-5362768;Reactome: R-HSA-5358346;Reactome: R-HSA-69017;Reactome: R-HSA-69601;Reactome: R-HSA-8941858;Reactome: R-HSA-9010553;Reactome: R-HSA-350562;Reactome: R-HSA-5668541;Reactome: R-HSA-4641258;Reactome: R-HSA-211733;Reactome: R-HSA-5632684;Reactome: R-HSA-450408;Reactome: R-HSA-5610780;Reactome: R-HSA-1236974	"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"GLI3 is processed to GLI3R by the proteasome";"Defective CFTR causes cystic fibrosis";"Vif-mediated degradation of APOBEC3G";"Downstream TCR signaling";"Ubiquitin-dependent degradation of Cyclin D";"Degradation of AXIN";"Asymmetric localization of PCP proteins";"Cross-presentation of soluble exogenous antigens (endosomes)";"Autodegradation of the E3 ubiquitin ligase COP1";"Ub-specific processing proteases";"Neddylation";"Autodegradation of Cdh1 by Cdh1:APC/C";"Separation of Sister Chromatids";"Regulation of RUNX2 expression and activity";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"APC/C:Cdc20 mediated degradation of Securin";"Neutrophil degranulation";"Antigen processing: Ubiquitination & Proteasome degradation";"Regulation of RAS by GAPs";"Dectin-1 mediated noncanonical NF-kB signaling";"Degradation of GLI2 by the proteasome";"The role of GTSE1 in G2/M progression after G2 checkpoint";"G2/M Checkpoints";"Regulation of PTEN stability and activity";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Vpu mediated degradation of CD4";"SCF(Skp2)-mediated degradation of p27/p21";"CLEC7A (Dectin-1) signaling";"CDT1 association with the CDC6:ORC:origin complex";"UCH proteinases";"MAPK6/MAPK4 signaling";"SCF-beta-TrCP mediated degradation of Emi1";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Interleukin-1 signaling";"Degradation of beta-catenin by the destruction complex";"FCERI mediated NF-kB activation";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Activation of NF-kappaB in B cells";"Orc1 removal from chromatin";"ABC-family proteins mediated transport";"NIK-->noncanonical NF-kB signaling";"Negative regulation of NOTCH4 signaling";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Hedgehog ligand biogenesis";"CDK-mediated phosphorylation and removal of Cdc6";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Regulation of RUNX3 expression and activity";"Regulation of expression of SLITs and ROBOs";"Regulation of ornithine decarboxylase (ODC)";"TNFR2 non-canonical NF-kB pathway";"Degradation of DVL";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Hedgehog 'on' state";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Degradation of GLI1 by the proteasome";"ER-Phagosome pathway"
XP_046433803.1	6	MetaCyc: PWY-5668;KEGG: 00564+2.7.8.5;Reactome: R-HSA-1483148;MetaCyc: PWY-7817;MetaCyc: PWY-5269;Reactome: R-HSA-1483166	"Cardiolipin biosynthesis I";"Glycerophospholipid metabolism";"Synthesis of PG";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Cardiolipin biosynthesis II";"Synthesis of PA"
XP_046432337.1	7	Reactome: R-HSA-380259;Reactome: R-HSA-8854518;Reactome: R-HSA-2565942;Reactome: R-HSA-380270;Reactome: R-HSA-380320;Reactome: R-HSA-380284;Reactome: R-HSA-5620912	"Loss of Nlp from mitotic centrosomes";"AURKA Activation by TPX2";"Regulation of PLK1 Activity at G2/M Transition";"Recruitment of mitotic centrosome proteins and complexes";"Recruitment of NuMA to mitotic centrosomes";"Loss of proteins required for interphase microtubule organization from the centrosome";"Anchoring of the basal body to the plasma membrane"
XP_046425247.1	4	Reactome: R-HSA-73621;KEGG: 00910+1.4.1.14;KEGG: 00250+1.4.1.14;MetaCyc: PWY-6963	"Pyrimidine catabolism";"Nitrogen metabolism";"Alanine, aspartate and glutamate metabolism";"Ammonia assimilation cycle I"
XP_046421638.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046410462.1	5	Reactome: R-HSA-174403;MetaCyc: PWY-8043;Reactome: R-HSA-5579006;KEGG: 00480+6.3.2.3;KEGG: 00270+6.3.2.3	"Glutathione synthesis and recycling";"Ophthalmate biosynthesis";"Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)";"Glutathione metabolism";"Cysteine and methionine metabolism"
XP_046433800.1	6	Reactome: R-HSA-69052;Reactome: R-HSA-68949;Reactome: R-HSA-68962;Reactome: R-HSA-176187;Reactome: R-HSA-68867;Reactome: R-HSA-176974	"Switching of origins to a post-replicative state";"Orc1 removal from chromatin";"Activation of the pre-replicative complex";"Activation of ATR in response to replication stress";"Assembly of the pre-replicative complex";"Unwinding of DNA"
XP_046428818.1	1	Reactome: R-HSA-6799198	"Complex I biogenesis"
XP_046424910.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046417867.1	1	Reactome: R-HSA-196741	"Cobalamin (Cbl, vitamin B12) transport and metabolism"
XP_046427181.1	11	KEGG: 04926+2.7.11.1;Reactome: R-HSA-450302;Reactome: R-HSA-171007;KEGG: 05163+2.7.11.1;Reactome: R-HSA-4420097;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04714+2.7.11.1;Reactome: R-HSA-2559580	"Relaxin signaling pathway";"activated TAK1 mediates p38 MAPK activation";"p38MAPK events";"Human cytomegalovirus infection";"VEGFA-VEGFR2 Pathway";"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Thermogenesis";"Oxidative Stress Induced Senescence"
XP_046426217.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_046417546.1	2	Reactome: R-HSA-936837;Reactome: R-HSA-6798695	"Ion transport by P-type ATPases";"Neutrophil degranulation"
XP_046409484.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046430706.1	1	Reactome: R-HSA-418594	"G alpha (i) signalling events"
XP_046410750.1	10	Reactome: R-HSA-6807004;Reactome: R-HSA-917729;Reactome: R-HSA-8856828;Reactome: R-HSA-9635644;Reactome: R-HSA-9636383;Reactome: R-HSA-182971;Reactome: R-HSA-432720;Reactome: R-HSA-5689880;Reactome: R-HSA-8875360;Reactome: R-HSA-8856825	"Negative regulation of MET activity";"Endosomal Sorting Complex Required For Transport (ESCRT)";"Clathrin-mediated endocytosis";"Inhibition of membrane repair";"Prevention of phagosomal-lysosomal fusion";"EGFR downregulation";"Lysosome Vesicle Biogenesis";"Ub-specific processing proteases";"InlB-mediated entry of Listeria monocytogenes into host cell";"Cargo recognition for clathrin-mediated endocytosis"
XP_046427331.1	2	MetaCyc: PWY-6502;Reactome: R-HSA-2393930	"8-oxo-(d)GTP detoxification I";"Phosphate bond hydrolysis by NUDT proteins"
XP_046425515.1	2	KEGG: 00520+2.4.1.16;MetaCyc: PWY-6981	"Amino sugar and nucleotide sugar metabolism";"Chitin biosynthesis"
XP_046434121.1	3	KEGG: 00620+4.4.1.5;MetaCyc: PWY-5386;Reactome: R-HSA-70268	"Pyruvate metabolism";"Methylglyoxal degradation I";"Pyruvate metabolism"
XP_046410375.1	6	Reactome: R-HSA-156827;Reactome: R-HSA-72689;Reactome: R-HSA-72649;Reactome: R-HSA-72706;Reactome: R-HSA-72695;Reactome: R-HSA-72702	"L13a-mediated translational silencing of Ceruloplasmin expression";"Formation of a pool of free 40S subunits";"Translation initiation complex formation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Formation of the ternary complex, and subsequently, the 43S complex";"Ribosomal scanning and start codon recognition"
XP_046426507.1	2	KEGG: 00561+2.7.1.30;MetaCyc: PWY-4261	"Glycerolipid metabolism";"Glycerol degradation I"
XP_046424830.1	3	KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway"
XP_046418558.1	13	Reactome: R-HSA-192823;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-72689;Reactome: R-HSA-9633012;Reactome: R-HSA-1799339;Reactome: R-HSA-2408557;Reactome: R-HSA-72706;Reactome: R-HSA-6791226;Reactome: R-HSA-975957;Reactome: R-HSA-72764;Reactome: R-HSA-975956;Reactome: R-HSA-156902	"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Formation of a pool of free 40S subunits";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"SRP-dependent cotranslational protein targeting to membrane";"Selenocysteine synthesis";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Peptide chain elongation"
XP_046417576.1	2	Reactome: R-HSA-2151201;Reactome: R-HSA-163282	"Transcriptional activation of mitochondrial biogenesis";"Mitochondrial transcription initiation"
XP_046418073.1	4	MetaCyc: PWY-5737;Reactome: R-HSA-70688;KEGG: 00330+1.5.5.2;MetaCyc: PWY-6922	"(5R)-carbapenem carboxylate biosynthesis";"Proline catabolism";"Arginine and proline metabolism";"L-Ndelta-acetylornithine biosynthesis"
XP_046413523.1	2	Reactome: R-HSA-9033241;Reactome: R-HSA-5656169	"Peroxisomal protein import";"Termination of translesion DNA synthesis"
XP_046433455.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_046412305.1	4	Reactome: R-HSA-72764;Reactome: R-HSA-6782315;Reactome: R-HSA-6790901;Reactome: R-HSA-156581	"Eukaryotic Translation Termination";"tRNA modification in the nucleus and cytosol";"rRNA modification in the nucleus and cytosol";"Methylation"
XP_046421062.1	4	Reactome: R-HSA-6811434;Reactome: R-HSA-2132295;Reactome: R-HSA-5625970;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"MHC class II antigen presentation";"RHO GTPases activate KTN1";"Kinesins"
XP_046436683.1	12	Reactome: R-HSA-2132295;Reactome: R-HSA-9609690;Reactome: R-HSA-68877;Reactome: R-HSA-2467813;Reactome: R-HSA-6811436;Reactome: R-HSA-9646399;Reactome: R-HSA-9648025;Reactome: R-HSA-141444;Reactome: R-HSA-5663220;Reactome: R-HSA-2500257;Reactome: R-HSA-6807878;Reactome: R-HSA-3371497	"MHC class II antigen presentation";"HCMV Early Events";"Mitotic Prometaphase";"Separation of Sister Chromatids";"COPI-independent Golgi-to-ER retrograde traffic";"Aggrephagy";"EML4 and NUDC in mitotic spindle formation";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"RHO GTPases Activate Formins";"Resolution of Sister Chromatid Cohesion";"COPI-mediated anterograde transport";"HSP90 chaperone cycle for steroid hormone receptors (SHR)"
XP_046411651.1	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
XP_046421353.1	1	Reactome: R-HSA-9037629	"Lewis blood group biosynthesis"
XP_046420504.1	1	Reactome: R-HSA-428359	"Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA"
XP_046431722.1	2	Reactome: R-HSA-3295583;Reactome: R-HSA-418890	"TRP channels";"Role of second messengers in netrin-1 signaling"
XP_046431473.1	1	Reactome: R-HSA-163560	"Triglyceride catabolism"
XP_046435875.1	3	Reactome: R-HSA-6807878;Reactome: R-HSA-8963901;Reactome: R-HSA-445095	"COPI-mediated anterograde transport";"Chylomicron remodeling";"Interaction between L1 and Ankyrins"
XP_046432109.1	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
XP_046409610.1	2	Reactome: R-HSA-877300;Reactome: R-HSA-2132295	"Interferon gamma signaling";"MHC class II antigen presentation"
XP_046432981.1	1	Reactome: R-HSA-70221	"Glycogen breakdown (glycogenolysis)"
XP_046410278.1	2	Reactome: R-HSA-429947;Reactome: R-HSA-6804115	"Deadenylation of mRNA";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"
XP_046421235.1	7	MetaCyc: PWY-6470;MetaCyc: PWY-6385;Reactome: R-HSA-5633231;MetaCyc: PWY-6471;KEGG: 00550+2.4.1.227;Reactome: R-HSA-446193;MetaCyc: PWY-5265	"Peptidoglycan biosynthesis V (beta-lactam resistance)";"Peptidoglycan biosynthesis III (mycobacteria)";"Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)";"Peptidoglycan biosynthesis IV (Enterococcus faecium)";"Peptidoglycan biosynthesis";"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"Peptidoglycan biosynthesis II (staphylococci)"
XP_046427191.1	11	KEGG: 04714+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;Reactome: R-HSA-2559580;Reactome: R-HSA-450302;Reactome: R-HSA-171007;Reactome: R-HSA-4420097;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1	"Thermogenesis";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Oxidative Stress Induced Senescence";"activated TAK1 mediates p38 MAPK activation";"p38MAPK events";"VEGFA-VEGFR2 Pathway";"Human cytomegalovirus infection";"Relaxin signaling pathway";"mTOR signaling pathway";"PI3K-Akt signaling pathway"
XP_046425693.1	18	KEGG: 00270+2.6.1.1;KEGG: 00960+2.6.1.1;KEGG: 00710+2.6.1.1;KEGG: 00350+2.6.1.1;MetaCyc: PWY-6643;KEGG: 00330+2.6.1.1;KEGG: 00220+2.6.1.1;KEGG: 00250+2.6.1.1;MetaCyc: PWY-7117;MetaCyc: PWY-6638;KEGG: 00400+2.6.1.1;KEGG: 00401+2.6.1.1;KEGG: 00360+2.6.1.1;MetaCyc: PWY-7115;MetaCyc: PWY-6642;MetaCyc: PWY-7383;KEGG: 00950+2.6.1.1;MetaCyc: PWY-5913	"Cysteine and methionine metabolism";"Tropane, piperidine and pyridine alkaloid biosynthesis";"Carbon fixation in photosynthetic organisms";"Tyrosine metabolism";"Coenzyme M biosynthesis II";"Arginine and proline metabolism";"Arginine biosynthesis";"Alanine, aspartate and glutamate metabolism";"C4 photosynthetic carbon assimilation cycle, PEPCK type";"Sulfolactate degradation III";"Phenylalanine, tyrosine and tryptophan biosynthesis";"Novobiocin biosynthesis";"Phenylalanine metabolism";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"(R)-cysteate degradation";"Anaerobic energy metabolism (invertebrates, cytosol)";"Isoquinoline alkaloid biosynthesis";"Partial TCA cycle (obligate autotrophs)"
XP_046410314.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_046433954.1	2	Reactome: R-HSA-388479;Reactome: R-HSA-416476	"Vasopressin-like receptors";"G alpha (q) signalling events"
XP_046434449.1	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
XP_046415116.1	1	Reactome: R-HSA-3299685	"Detoxification of Reactive Oxygen Species"
XP_046432965.1	1	Reactome: R-HSA-435368	"Zinc efflux and compartmentalization by the SLC30 family"
XP_046418189.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046411565.1	1	Reactome: R-HSA-429947	"Deadenylation of mRNA"
XP_046413594.1	5	Reactome: R-HSA-5628897;Reactome: R-HSA-111447;Reactome: R-HSA-75035;Reactome: R-HSA-1445148;Reactome: R-HSA-5625740	"TP53 Regulates Metabolic Genes";"Activation of BAD and translocation to mitochondria";"Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"RHO GTPases activate PKNs"
XP_046416361.1	1	Reactome: R-HSA-425561	"Sodium/Calcium exchangers"
XP_046433874.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_046433268.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046411712.1	6	Reactome: R-HSA-141444;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813;Reactome: R-HSA-68877;Reactome: R-HSA-2500257;Reactome: R-HSA-5663220	"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids";"Mitotic Prometaphase";"Resolution of Sister Chromatid Cohesion";"RHO GTPases Activate Formins"
XP_046427540.1	9	Reactome: R-HSA-975634;Reactome: R-HSA-3656253;Reactome: R-HSA-1971475;Reactome: R-HSA-2022928;Reactome: R-HSA-3656237;Reactome: R-HSA-2024096;Reactome: R-HSA-4420332;Reactome: R-HSA-3560801;Reactome: R-HSA-3560783	"Retinoid metabolism and transport";"Defective EXT1 causes exostoses 1, TRPS2 and CHDS";"A tetrasaccharide linker sequence is required for GAG synthesis";"HS-GAG biosynthesis";"Defective EXT2 causes exostoses 2";"HS-GAG degradation";"Defective B3GALT6 causes EDSP2 and SEMDJL1";"Defective B3GAT3 causes JDSSDHD";"Defective B4GALT7 causes EDS, progeroid type"
XP_046433333.1	5	Reactome: R-HSA-2426168;Reactome: R-HSA-381183;Reactome: R-HSA-9614657;Reactome: R-HSA-380994;Reactome: R-HSA-1989781	"Activation of gene expression by SREBF (SREBP)";"ATF6 (ATF6-alpha) activates chaperone genes";"FOXO-mediated transcription of cell death genes";"ATF4 activates genes in response to endoplasmic reticulum stress";"PPARA activates gene expression"
XP_046411621.1	5	KEGG: 00052+2.7.1.6;KEGG: 00520+2.7.1.6;MetaCyc: PWY-6527;MetaCyc: PWY-3821;MetaCyc: PWY-6317	"Galactose metabolism";"Amino sugar and nucleotide sugar metabolism";"Stachyose degradation";"D-galactose detoxification";"D-galactose degradation I (Leloir pathway)"
XP_046417355.1	2	MetaCyc: PWY-7802;MetaCyc: PWY-7799	"N-end rule pathway II (prokaryotic)";"Arg/N-end rule pathway (eukaryotic)"
XP_046414764.1	19	Reactome: R-HSA-8963888;Reactome: R-HSA-8866423;Reactome: R-HSA-3000480;Reactome: R-HSA-3000497;Reactome: R-HSA-8964041;Reactome: R-HSA-3000484;Reactome: R-HSA-381426;Reactome: R-HSA-975634;Reactome: R-HSA-202733;Reactome: R-HSA-8964046;Reactome: R-HSA-5686938;Reactome: R-HSA-3000471;Reactome: R-HSA-8856825;Reactome: R-HSA-8856828;Reactome: R-HSA-432142;Reactome: R-HSA-8963901;Reactome: R-HSA-8964026;Reactome: R-HSA-8964038;Reactome: R-HSA-8957275	"Chylomicron assembly";"VLDL assembly";"Scavenging by Class A Receptors";"Scavenging by Class H Receptors";"LDL remodeling";"Scavenging by Class F Receptors";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"Retinoid metabolism and transport";"Cell surface interactions at the vascular wall";"VLDL clearance";"Regulation of TLR by endogenous ligand";"Scavenging by Class B Receptors";"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis";"Platelet sensitization by LDL";"Chylomicron remodeling";"Chylomicron clearance";"LDL clearance";"Post-translational protein phosphorylation"
XP_046424986.1	11	Reactome: R-HSA-432040;Reactome: R-HSA-418594;KEGG: 00230+4.6.1.1;Reactome: R-HSA-170670;Reactome: R-HSA-163615;Reactome: R-HSA-5610787;Reactome: R-HSA-164378;Reactome: R-HSA-163359;Reactome: R-HSA-418597;Reactome: R-HSA-170660;Reactome: R-HSA-418555	"Vasopressin regulates renal water homeostasis via Aquaporins";"G alpha (i) signalling events";"Purine metabolism";"Adenylate cyclase inhibitory pathway";"PKA activation";"Hedgehog 'off' state";"PKA activation in glucagon signalling";"Glucagon signaling in metabolic regulation";"G alpha (z) signalling events";"Adenylate cyclase activating pathway";"G alpha (s) signalling events"
XP_046414409.1	5	Reactome: R-HSA-77595;Reactome: R-HSA-73856;Reactome: R-HSA-72163;Reactome: R-HSA-72187;Reactome: R-HSA-159231	"Processing of Intronless Pre-mRNAs";"RNA Polymerase II Transcription Termination";"mRNA Splicing - Major Pathway";"mRNA 3'-end processing";"Transport of Mature mRNA Derived from an Intronless Transcript"
XP_046419391.1	6	MetaCyc: PWY-7782;MetaCyc: PWY-5884;MetaCyc: PWY-7656;KEGG: 00073+1.2.1.84;MetaCyc: PWY-6733;Reactome: R-HSA-9640463	"Plasmalogen biosynthesis";"Wax esters biosynthesis I";"Spodoptera littoralis pheromone biosynthesis";"Cutin, suberine and wax biosynthesis";"Sporopollenin precursors biosynthesis";"Wax biosynthesis"
XP_046429055.1	1	Reactome: R-HSA-1632852	"Macroautophagy"
XP_046420616.1	1	Reactome: R-HSA-400253	"Circadian Clock"
XP_046433983.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_046423755.1	8	MetaCyc: PWY-7817;MetaCyc: PWY-5668;Reactome: R-HSA-1483148;MetaCyc: PWY-5269;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 00564+3.1.3.27;KEGG: 05235+3.1.3.16	"Type I lipoteichoic acid biosynthesis (S. aureus)";"Cardiolipin biosynthesis I";"Synthesis of PG";"Cardiolipin biosynthesis II";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation";"Glycerophospholipid metabolism";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
XP_046430371.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046426347.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_046414784.1	14	MetaCyc: PWY-181;Reactome: R-HSA-196757;KEGG: 00670+2.1.2.1;MetaCyc: PWY-3661-1;KEGG: 00680+2.1.2.1;MetaCyc: PWY-3841;MetaCyc: PWY-3661;KEGG: 00260+2.1.2.1;MetaCyc: PWY-2161;KEGG: 00460+2.1.2.1;MetaCyc: PWY-5497;KEGG: 00630+2.1.2.1;MetaCyc: PWY-1622;MetaCyc: PWY-2201	"Photorespiration ";"Metabolism of folate and pterines";"One carbon pool by folate";"Glycine betaine degradation II (mammalian)";"Methane metabolism";"Folate transformations II (plants)";"Glycine betaine degradation I";"Glycine, serine and threonine metabolism";"Folate polyglutamylation";"Cyanoamino acid metabolism";"Purine nucleobases degradation II (anaerobic)";"Glyoxylate and dicarboxylate metabolism";"Formaldehyde assimilation I (serine pathway)";"Folate transformations I"
XP_046422137.1	6	Reactome: R-HSA-189085;KEGG: 00500+2.4.1.18;KEGG: 00500+3.2.1.1;MetaCyc: PWY-5067;MetaCyc: PWY-622;MetaCyc: PWY-7900	"Digestion of dietary carbohydrate";"Starch and sucrose metabolism";"Starch and sucrose metabolism";"Glycogen biosynthesis II (from UDP-D-Glucose)";"Starch biosynthesis";"Glycogen biosynthesis III (from alpha-maltose 1-phosphate)"
XP_046421990.1	2	Reactome: R-HSA-418457;Reactome: R-HSA-1296052	"cGMP effects";"Ca2+ activated K+ channels"
XP_046426017.1	20	MetaCyc: PWY-7606;MetaCyc: PWY-7726;MetaCyc: PWY-7854;MetaCyc: PWY-7007;MetaCyc: PWY-7574;MetaCyc: PWY-7337;MetaCyc: PWY-7288;MetaCyc: PWY-7340;KEGG: 00071+1.3.3.6;MetaCyc: PWY-7338;MetaCyc: PWY-7858;MetaCyc: PWY-7291;MetaCyc: PWY-6920;KEGG: 00410+1.3.3.6;Reactome: R-HSA-9033241;MetaCyc: PWY-5136;MetaCyc: PWY-735;KEGG: 00592+1.3.3.6;KEGG: 00640+1.3.3.6;MetaCyc: PWY-6837	"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"Crotonyl-coa/ethylmalonyl-coa/hydroxybutyryl-coa cycle (engineered)";"Methyl ketone biosynthesis (engineered)";"Propanoyl-coa degradation II";"10-cis-heptadecenoyl-CoA degradation (yeast)";"Fatty acid beta-oxidation VII (yeast peroxisome)";"9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast)";"Fatty acid degradation";"10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast)";"(5Z)-dodecenoate biosynthesis II";"Oleate beta-oxidation (isomerase-dependent, yeast)";"6-gingerol analog biosynthesis (engineered)";"beta-Alanine metabolism";"Peroxisomal protein import";"Fatty acid beta-oxidation II (plant peroxisome)";"Jasmonic acid biosynthesis";"alpha-Linolenic acid metabolism";"Propanoate metabolism";"Fatty acid beta-oxidation V (unsaturated, odd number, di-isomerase-dependent)"
XP_046425442.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046423232.1	13	Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-192823;Reactome: R-HSA-9633012;Reactome: R-HSA-72689;Reactome: R-HSA-1799339;Reactome: R-HSA-72706;Reactome: R-HSA-2408557;Reactome: R-HSA-6791226;Reactome: R-HSA-975957;Reactome: R-HSA-72764;Reactome: R-HSA-156902;Reactome: R-HSA-975956	"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Viral mRNA Translation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Formation of a pool of free 40S subunits";"SRP-dependent cotranslational protein targeting to membrane";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Selenocysteine synthesis";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"
XP_046416534.1	1	Reactome: R-HSA-163765	"ChREBP activates metabolic gene expression"
XP_046422009.1	7	Reactome: R-HSA-1632852;Reactome: R-HSA-166208;Reactome: R-HSA-165159;Reactome: R-HSA-380972;Reactome: R-HSA-5628897;Reactome: R-HSA-9639288;Reactome: R-HSA-8943724	"Macroautophagy";"mTORC1-mediated signalling";"mTOR signalling";"Energy dependent regulation of mTOR by LKB1-AMPK";"TP53 Regulates Metabolic Genes";"Amino acids regulate mTORC1";"Regulation of PTEN gene transcription"
XP_046435883.1	3	Reactome: R-HSA-445095;Reactome: R-HSA-8963901;Reactome: R-HSA-6807878	"Interaction between L1 and Ankyrins";"Chylomicron remodeling";"COPI-mediated anterograde transport"
XP_046433751.1	1	Reactome: R-HSA-389957	"Prefoldin mediated transfer of substrate to CCT/TriC"
XP_046436325.1	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
XP_046431341.1	2	Reactome: R-HSA-8949613;Reactome: R-HSA-163210	"Cristae formation";"Formation of ATP by chemiosmotic coupling"
XP_046430261.1	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
XP_046426213.1	3	Reactome: R-HSA-416482;Reactome: R-HSA-194840;Reactome: R-HSA-193648	"G alpha (12/13) signalling events";"Rho GTPase cycle";"NRAGE signals death through JNK"
XP_046422040.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046433143.1	1	Reactome: R-HSA-1632852	"Macroautophagy"
XP_046432711.1	2	Reactome: R-HSA-69273;Reactome: R-HSA-8862803	"Cyclin A/B1/B2 associated events during G2/M transition";"Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models"
XP_046432103.1	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
XP_046435368.1	2	Reactome: R-HSA-8856828;Reactome: R-HSA-8856825	"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis"
XP_046414732.1	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046419125.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_046434473.1	1	KEGG: 00010+5.1.3.15	"Glycolysis / Gluconeogenesis"
XP_046427632.1	1	Reactome: R-HSA-426486	"Small interfering RNA (siRNA) biogenesis"
XP_046418192.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046425477.1	3	Reactome: R-HSA-112311;Reactome: R-HSA-1483191;Reactome: R-HSA-422085	"Neurotransmitter clearance";"Synthesis of PC";"Synthesis, secretion, and deacylation of Ghrelin"
XP_046417002.1	5	Reactome: R-HSA-2206305;Reactome: R-HSA-432720;KEGG: 00531+3.1.6.14;Reactome: R-HSA-2022857;Reactome: R-HSA-6798695	"MPS IIID - Sanfilippo syndrome D";"Lysosome Vesicle Biogenesis";"Glycosaminoglycan degradation";"Keratan sulfate degradation";"Neutrophil degranulation"
XP_046411429.1	5	MetaCyc: PWY-7269;KEGG: 00760+2.7.1.23;MetaCyc: PWY-5083;MetaCyc: PWY-7268;Reactome: R-HSA-196807	"NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)";"Nicotinate and nicotinamide metabolism";"NAD/NADH phosphorylation and dephosphorylation";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"Nicotinate metabolism"
XP_046423622.1	2	Reactome: R-HSA-5694530;Reactome: R-HSA-204005	"Cargo concentration in the ER";"COPII-mediated vesicle transport"
XP_046415016.1	7	Reactome: R-HSA-210500;MetaCyc: PWY-5921;KEGG: 00250+3.5.1.2;Reactome: R-HSA-5628897;Reactome: R-HSA-8964539;KEGG: 00471+3.5.1.2;KEGG: 00220+3.5.1.2	"Glutamate Neurotransmitter Release Cycle";"Glutaminyl-trnagln biosynthesis via transamidation";"Alanine, aspartate and glutamate metabolism";"TP53 Regulates Metabolic Genes";"Glutamate and glutamine metabolism";"D-Glutamine and D-glutamate metabolism";"Arginine biosynthesis"
XP_046427978.1	14	Reactome: R-HSA-9029569;Reactome: R-HSA-426496;Reactome: R-HSA-5687128;Reactome: R-HSA-9022692;Reactome: R-HSA-203927;Reactome: R-HSA-8948700;Reactome: R-HSA-5628897;Reactome: R-HSA-8943723;Reactome: R-HSA-1912408;Reactome: R-HSA-8986944;Reactome: R-HSA-4086398;Reactome: R-HSA-9018519;Reactome: R-HSA-8934593;Reactome: R-HSA-426486	"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Post-transcriptional silencing by small RNAs";"MAPK6/MAPK4 signaling";"Regulation of MECP2 expression and activity";"MicroRNA (miRNA) biogenesis";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"TP53 Regulates Metabolic Genes";"Regulation of PTEN mRNA translation";"Pre-NOTCH Transcription and Translation";"Transcriptional Regulation by MECP2";"Ca2+ pathway";"Estrogen-dependent gene expression";"Regulation of RUNX1 Expression and Activity";"Small interfering RNA (siRNA) biogenesis"
XP_046410595.1	1	Reactome: R-HSA-6799198	"Complex I biogenesis"
XP_046409692.1	1	Reactome: R-HSA-163125	"Post-translational modification: synthesis of GPI-anchored proteins"
XP_046434695.1	3	MetaCyc: PWY-6596;Reactome: R-HSA-74217;KEGG: 00230+3.5.4.6	"Adenosine nucleotides degradation I";"Purine salvage";"Purine metabolism"
XP_046432017.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_046428660.1	1	Reactome: R-HSA-197264	"Nicotinamide salvaging"
XP_046409944.1	2	Reactome: R-HSA-71403;Reactome: R-HSA-611105	"Citric acid cycle (TCA cycle)";"Respiratory electron transport"
XP_046411675.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_046409645.1	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
XP_046429575.1	2	Reactome: R-HSA-1369007;Reactome: R-HSA-5683371	"Mitochondrial ABC transporters";"Defective ABCB6 causes isolated colobomatous microphthalmia 7 (MCOPCB7)"
XP_046418937.1	1	Reactome: R-HSA-5693571	"Nonhomologous End-Joining (NHEJ)"
XP_046412796.1	5	Reactome: R-HSA-1445148;Reactome: R-HSA-1660499;Reactome: R-HSA-8873719;Reactome: R-HSA-8876198;Reactome: R-HSA-6798695	"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Synthesis of PIPs at the plasma membrane";"RAB geranylgeranylation";"RAB GEFs exchange GTP for GDP on RABs";"Neutrophil degranulation"
XP_046430245.1	5	KEGG: 00290+4.2.1.33;KEGG: 00020+4.2.1.3;KEGG: 00630+4.2.1.3;Reactome: R-HSA-917937;KEGG: 00720+4.2.1.3	"Valine, leucine and isoleucine biosynthesis";"Citrate cycle (TCA cycle)";"Glyoxylate and dicarboxylate metabolism";"Iron uptake and transport";"Carbon fixation pathways in prokaryotes"
XP_046425822.1	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_046436673.1	12	Reactome: R-HSA-2132295;Reactome: R-HSA-9648025;Reactome: R-HSA-141444;Reactome: R-HSA-9609690;Reactome: R-HSA-68877;Reactome: R-HSA-9646399;Reactome: R-HSA-2467813;Reactome: R-HSA-6811436;Reactome: R-HSA-5663220;Reactome: R-HSA-2500257;Reactome: R-HSA-3371497;Reactome: R-HSA-6807878	"MHC class II antigen presentation";"EML4 and NUDC in mitotic spindle formation";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"HCMV Early Events";"Mitotic Prometaphase";"Aggrephagy";"Separation of Sister Chromatids";"COPI-independent Golgi-to-ER retrograde traffic";"RHO GTPases Activate Formins";"Resolution of Sister Chromatid Cohesion";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-mediated anterograde transport"
XP_046411830.1	8	KEGG: 00010+1.1.1.27;MetaCyc: PWY-6901;KEGG: 00620+1.1.1.27;KEGG: 00270+1.1.1.27;MetaCyc: PWY-5481;MetaCyc: PWY-8086;Reactome: R-HSA-70268;KEGG: 00640+1.1.1.27	"Glycolysis / Gluconeogenesis";"Superpathway of glucose and xylose degradation";"Pyruvate metabolism";"Cysteine and methionine metabolism";"Pyruvate fermentation to (S)-lactate";"(S)-lactate fermentation to propanoate, acetate and hydrogen";"Pyruvate metabolism";"Propanoate metabolism"
XP_046424309.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_046430266.1	9	KEGG: 00562+3.1.4.11;MetaCyc: PWY-7039;MetaCyc: PWY-6351;MetaCyc: PWY-8052;MetaCyc: PWY-6367;Reactome: R-HSA-112043;KEGG: 04070+3.1.4.11;Reactome: R-HSA-1855204;Reactome: R-HSA-416476	"Inositol phosphate metabolism";"Phosphatidate metabolism, as a signaling molecule";"D-myo-inositol (1,4,5)-trisphosphate biosynthesis";"2-arachidonoylglycerol biosynthesis";"D-myo-inositol-5-phosphate metabolism";"PLC beta mediated events";"Phosphatidylinositol signaling system";"Synthesis of IP3 and IP4 in the cytosol";"G alpha (q) signalling events"
XP_046435591.1	56	Reactome: R-HSA-5607764;Reactome: R-HSA-187577;Reactome: R-HSA-180534;Reactome: R-HSA-5689603;Reactome: R-HSA-68827;Reactome: R-HSA-8852276;Reactome: R-HSA-5610783;Reactome: R-HSA-8948751;Reactome: R-HSA-1234176;Reactome: R-HSA-69481;Reactome: R-HSA-9020702;Reactome: R-HSA-8854050;Reactome: R-HSA-5687128;Reactome: R-HSA-174113;Reactome: R-HSA-69017;Reactome: R-HSA-69601;Reactome: R-HSA-5358346;Reactome: R-HSA-5362768;Reactome: R-HSA-9604323;Reactome: R-HSA-5676590;Reactome: R-HSA-174178;Reactome: R-HSA-2871837;Reactome: R-HSA-195253;Reactome: R-HSA-68949;Reactome: R-HSA-1169091;Reactome: R-HSA-382556;Reactome: R-HSA-5632684;Reactome: R-HSA-211733;Reactome: R-HSA-4641258;Reactome: R-HSA-1236974;Reactome: R-HSA-450408;Reactome: R-HSA-5610780;Reactome: R-HSA-5668541;Reactome: R-HSA-9010553;Reactome: R-HSA-8941858;Reactome: R-HSA-350562;Reactome: R-HSA-5610785;Reactome: R-HSA-180585;Reactome: R-HSA-5678895;Reactome: R-HSA-8939236;Reactome: R-HSA-349425;Reactome: R-HSA-5689880;Reactome: R-HSA-174084;Reactome: R-HSA-8951664;Reactome: R-HSA-4641257;Reactome: R-HSA-4608870;Reactome: R-HSA-202424;Reactome: R-HSA-75815;Reactome: R-HSA-1236978;Reactome: R-HSA-174184;Reactome: R-HSA-8939902;Reactome: R-HSA-174154;Reactome: R-HSA-2467813;Reactome: R-HSA-5658442;Reactome: R-HSA-983168;Reactome: R-HSA-5607761	"CLEC7A (Dectin-1) signaling";"SCF(Skp2)-mediated degradation of p27/p21";"Vpu mediated degradation of CD4";"UCH proteinases";"CDT1 association with the CDC6:ORC:origin complex";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Degradation of GLI2 by the proteasome";"Regulation of PTEN stability and activity";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"G2/M Checkpoints";"Interleukin-1 signaling";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"MAPK6/MAPK4 signaling";"SCF-beta-TrCP mediated degradation of Emi1";"CDK-mediated phosphorylation and removal of Cdc6";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Hedgehog ligand biogenesis";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Negative regulation of NOTCH4 signaling";"NIK-->noncanonical NF-kB signaling";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"FCERI mediated NF-kB activation";"Degradation of beta-catenin by the destruction complex";"Orc1 removal from chromatin";"Activation of NF-kappaB in B cells";"ABC-family proteins mediated transport";"Hedgehog 'on' state";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Degradation of DVL";"ER-Phagosome pathway";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Degradation of GLI1 by the proteasome";"TNFR2 non-canonical NF-kB pathway";"Regulation of expression of SLITs and ROBOs";"Regulation of RUNX3 expression and activity";"Regulation of ornithine decarboxylase (ODC)";"GLI3 is processed to GLI3R by the proteasome";"Vif-mediated degradation of APOBEC3G";"Defective CFTR causes cystic fibrosis";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Autodegradation of the E3 ubiquitin ligase COP1";"Ub-specific processing proteases";"Autodegradation of Cdh1 by Cdh1:APC/C";"Neddylation";"Degradation of AXIN";"Asymmetric localization of PCP proteins";"Downstream TCR signaling";"Ubiquitin-dependent degradation of Cyclin D";"Cross-presentation of soluble exogenous antigens (endosomes)";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Regulation of RUNX2 expression and activity";"APC/C:Cdc20 mediated degradation of Securin";"Separation of Sister Chromatids";"Regulation of RAS by GAPs";"Antigen processing: Ubiquitination & Proteasome degradation";"Dectin-1 mediated noncanonical NF-kB signaling"
XP_046424289.1	2	Reactome: R-HSA-2142691;Reactome: R-HSA-2142700	"Synthesis of Leukotrienes (LT) and Eoxins (EX)";"Synthesis of Lipoxins (LX)"
XP_046427267.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046426937.1	6	MetaCyc: PWY-5497;Reactome: R-HSA-74259;MetaCyc: PWY-7442;MetaCyc: PWY-6608;KEGG: 00230+3.5.4.3;MetaCyc: PWY-6606	"Purine nucleobases degradation II (anaerobic)";"Purine catabolism";"Drosopterin and aurodrosopterin biosynthesis";"Guanosine nucleotides degradation III";"Purine metabolism";"Guanosine nucleotides degradation II"
XP_046423327.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046421181.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046409308.1	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
XP_046416488.1	7	Reactome: R-HSA-983168;MetaCyc: PWY-7511;Reactome: R-HSA-5693565;Reactome: R-HSA-5693607;Reactome: R-HSA-3108214;Reactome: R-HSA-5693571;Reactome: R-HSA-69473	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Processing of DNA double-strand break ends";"SUMOylation of DNA damage response and repair proteins";"Nonhomologous End-Joining (NHEJ)";"G2/M DNA damage checkpoint"
XP_046413786.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046435590.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046426798.1	9	Reactome: R-HSA-68962;Reactome: R-HSA-174411;Reactome: R-HSA-69183;Reactome: R-HSA-69166;Reactome: R-HSA-174430;Reactome: R-HSA-113501;Reactome: R-HSA-68952;Reactome: R-HSA-69205;Reactome: R-HSA-69091	"Activation of the pre-replicative complex";"Polymerase switching on the C-strand of the telomere";"Processive synthesis on the lagging strand";"Removal of the Flap Intermediate";"Telomere C-strand synthesis initiation";"Inhibition of replication initiation of damaged DNA by RB1/E2F1";"DNA replication initiation";"G1/S-Specific Transcription";"Polymerase switching"
XP_046428734.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_046427156.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_046415768.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_046427626.1	2	Reactome: R-HSA-189085;KEGG: 00500+3.2.1.28	"Digestion of dietary carbohydrate";"Starch and sucrose metabolism"
XP_046425307.1	9	Reactome: R-HSA-167287;Reactome: R-HSA-6796648;Reactome: R-HSA-674695;Reactome: R-HSA-167152;Reactome: R-HSA-167290;Reactome: R-HSA-75955;Reactome: R-HSA-6807505;Reactome: R-HSA-2173796;Reactome: R-HSA-112382	"HIV elongation arrest and recovery";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Pre-transcription Events";"Formation of HIV elongation complex in the absence of HIV Tat";"Pausing and recovery of HIV elongation";"RNA Polymerase II Transcription Elongation";"RNA polymerase II transcribes snRNA genes";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"Formation of RNA Pol II elongation complex"
XP_046434083.1	5	Reactome: R-HSA-5668599;Reactome: R-HSA-936440;Reactome: R-HSA-6804756;Reactome: R-HSA-6811555;Reactome: R-HSA-1169408	"RHO GTPases Activate NADPH Oxidases";"Negative regulators of DDX58/IFIH1 signaling";"Regulation of TP53 Activity through Phosphorylation";"PI5P Regulates TP53 Acetylation";"ISG15 antiviral mechanism"
XP_046426499.1	7	KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1	"Human cytomegalovirus infection";"Thermogenesis";"Relaxin signaling pathway";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"PI3K-Akt signaling pathway";"mTOR signaling pathway"
XP_046431113.1	1	Reactome: R-HSA-6787450	"tRNA modification in the mitochondrion"
XP_046413433.1	11	Reactome: R-HSA-8863795;Reactome: R-HSA-1963642;Reactome: R-HSA-6811558;Reactome: R-HSA-1250196;Reactome: R-HSA-9664565;Reactome: R-HSA-5673001;Reactome: R-HSA-1227986;Reactome: R-HSA-8847993;Reactome: R-HSA-1257604;Reactome: R-HSA-6785631;Reactome: R-HSA-2219530	"Downregulation of ERBB2 signaling";"PI3K events in ERBB2 signaling";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"SHC1 events in ERBB2 signaling";"Signaling by ERBB2 KD Mutants";"RAF/MAP kinase cascade";"Signaling by ERBB2";"ERBB2 Activates PTK6 Signaling";"PIP3 activates AKT signaling";"ERBB2 Regulates Cell Motility";"Constitutive Signaling by Aberrant PI3K in Cancer"
XP_046418913.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_046426136.1	10	MetaCyc: PWY-6362;KEGG: 00562+2.7.1.158;MetaCyc: PWY-6554;Reactome: R-HSA-1855191;MetaCyc: PWY-6361;Reactome: R-HSA-1855167;MetaCyc: PWY-6372;KEGG: 04070+2.7.1.158;MetaCyc: PWY-4661;MetaCyc: PWY-6369	"1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)";"Inositol phosphate metabolism";"1D-myo-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3)";"Synthesis of IPs in the nucleus";"1D-myo-inositol hexakisphosphate biosynthesis I (from Ins(1,4,5)P3)";"Synthesis of pyrophosphates in the cytosol";"1D-myo-inositol hexakisphosphate biosynthesis IV (Dictyostelium)";"Phosphatidylinositol signaling system";"1D-myo-inositol hexakisphosphate biosynthesis III (Spirodela polyrrhiza)";"Inositol diphosphates biosynthesis"
XP_046413039.1	3	Reactome: R-HSA-3000171;Reactome: R-HSA-8874081;Reactome: R-HSA-3000157	"Non-integrin membrane-ECM interactions";"MET activates PTK2 signaling";"Laminin interactions"
XP_046422867.1	1	Reactome: R-HSA-6794361	"Neurexins and neuroligins"
XP_046413829.1	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046429673.1	2	Reactome: R-HSA-8854518;Reactome: R-HSA-2160916	"AURKA Activation by TPX2";"Hyaluronan uptake and degradation"
XP_046421857.1	1	Reactome: R-HSA-8873719	"RAB geranylgeranylation"
XP_046435881.1	3	Reactome: R-HSA-6807878;Reactome: R-HSA-8963901;Reactome: R-HSA-445095	"COPI-mediated anterograde transport";"Chylomicron remodeling";"Interaction between L1 and Ankyrins"
XP_046419776.1	1	Reactome: R-HSA-390522	"Striated Muscle Contraction"
XP_046416140.1	7	Reactome: R-HSA-76061;Reactome: R-HSA-76066;Reactome: R-HSA-76071;Reactome: R-HSA-1834949;Reactome: R-HSA-749476;Reactome: R-HSA-73980;Reactome: R-HSA-73780	"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Termination";"RNA Polymerase III Chain Elongation"
XP_046421768.1	7	KEGG: 00270+2.5.1.22;Reactome: R-HSA-351202;KEGG: 00480+2.5.1.22;KEGG: 00330+2.5.1.16;KEGG: 00480+2.5.1.16;KEGG: 00330+2.5.1.22;KEGG: 00270+2.5.1.16	"Cysteine and methionine metabolism";"Metabolism of polyamines";"Glutathione metabolism";"Arginine and proline metabolism";"Glutathione metabolism";"Arginine and proline metabolism";"Cysteine and methionine metabolism"
XP_046415763.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046431908.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046430705.1	1	Reactome: R-HSA-418594	"G alpha (i) signalling events"
XP_046410706.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_046428117.1	9	Reactome: R-HSA-167162;Reactome: R-HSA-167172;Reactome: R-HSA-75953;Reactome: R-HSA-76042;Reactome: R-HSA-167161;Reactome: R-HSA-6804756;Reactome: R-HSA-73779;Reactome: R-HSA-73776;Reactome: R-HSA-674695	"RNA Polymerase II HIV Promoter Escape";"Transcription of the HIV genome";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"HIV Transcription Initiation";"Regulation of TP53 Activity through Phosphorylation";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Pre-transcription Events"
XP_046435447.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046419771.1	1	Reactome: R-HSA-390522	"Striated Muscle Contraction"
XP_046424254.1	3	KEGG: 00480+4.3.2.7;MetaCyc: PWY-7942;Reactome: R-HSA-174403	"Glutathione metabolism";"5-oxo-L-proline metabolism";"Glutathione synthesis and recycling"
XP_046434044.1	1	Reactome: R-HSA-8953750	"Transcriptional Regulation by E2F6"
XP_046410846.1	7	KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1	"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Relaxin signaling pathway";"Thermogenesis";"Human cytomegalovirus infection"
XP_046415271.1	16	Reactome: R-HSA-72702;Reactome: R-HSA-975956;Reactome: R-HSA-6791226;Reactome: R-HSA-72706;Reactome: R-HSA-2408557;Reactome: R-HSA-9633012;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-156902;Reactome: R-HSA-72649;Reactome: R-HSA-72764;Reactome: R-HSA-975957;Reactome: R-HSA-72695;Reactome: R-HSA-1799339;Reactome: R-HSA-72689;Reactome: R-HSA-192823	"Ribosomal scanning and start codon recognition";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Selenocysteine synthesis";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Peptide chain elongation";"Translation initiation complex formation";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Formation of the ternary complex, and subsequently, the 43S complex";"SRP-dependent cotranslational protein targeting to membrane";"Formation of a pool of free 40S subunits";"Viral mRNA Translation"
XP_046411699.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046425781.1	2	Reactome: R-HSA-3299685;MetaCyc: PWY-6854	"Detoxification of Reactive Oxygen Species";"Ethylene biosynthesis III (microbes)"
XP_046422784.1	1	KEGG: 00970+6.1.1.22	"Aminoacyl-tRNA biosynthesis"
XP_046426576.1	2	Reactome: R-HSA-1296072;Reactome: R-HSA-5576894	"Voltage gated Potassium channels";"Phase 1 - inactivation of fast Na+ channels"
XP_046434870.1	1	Reactome: R-HSA-1445148	"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
XP_046429686.1	1	Reactome: R-HSA-388844	"Receptor-type tyrosine-protein phosphatases"
XP_046426787.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_046429841.1	1	KEGG: 00970+6.1.1.22	"Aminoacyl-tRNA biosynthesis"
XP_046429357.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_046419902.1	19	Reactome: R-HSA-6802955;Reactome: R-HSA-442982;Reactome: R-HSA-3371571;Reactome: R-HSA-6802952;Reactome: R-HSA-9649948;Reactome: R-HSA-5673001;Reactome: R-HSA-6802946;Reactome: R-HSA-5673000;Reactome: R-HSA-9620244;Reactome: R-HSA-936837;Reactome: R-HSA-399719;Reactome: R-HSA-5578775;Reactome: R-HSA-9609736;Reactome: R-HSA-438066;Reactome: R-HSA-111932;Reactome: R-HSA-9022692;Reactome: R-HSA-877300;Reactome: R-HSA-5576892;Reactome: R-HSA-9617324	"Paradoxical activation of RAF signaling by kinase inactive BRAF";"Ras activation upon Ca2+ influx through NMDA receptor";"HSF1-dependent transactivation";"Signaling by BRAF and RAF fusions";"Signaling downstream of RAS mutants";"RAF/MAP kinase cascade";"Signaling by moderate kinase activity BRAF mutants";"RAF activation";"Long-term potentiation";"Ion transport by P-type ATPases";"Trafficking of AMPA receptors";"Ion homeostasis";"Assembly and cell surface presentation of NMDA receptors";"Unblocking of NMDA receptors, glutamate binding and activation";"CaMK IV-mediated phosphorylation of CREB";"Regulation of MECP2 expression and activity";"Interferon gamma signaling";"Phase 0 - rapid depolarisation";"Negative regulation of NMDA receptor-mediated neuronal transmission"
XP_046411075.1	13	Reactome: R-HSA-2214320;Reactome: R-HSA-1650814;Reactome: R-HSA-3000171;Reactome: R-HSA-3000157;Reactome: R-HSA-3000178;Reactome: R-HSA-2243919;Reactome: R-HSA-419037;Reactome: R-HSA-216083;Reactome: R-HSA-8948216;Reactome: R-HSA-2022090;Reactome: R-HSA-1474244;Reactome: R-HSA-1442490;Reactome: R-HSA-186797	"Anchoring fibril formation";"Collagen biosynthesis and modifying enzymes";"Non-integrin membrane-ECM interactions";"Laminin interactions";"ECM proteoglycans";"Crosslinking of collagen fibrils";"NCAM1 interactions";"Integrin cell surface interactions";"Collagen chain trimerization";"Assembly of collagen fibrils and other multimeric structures";"Extracellular matrix organization";"Collagen degradation";"Signaling by PDGF"
XP_046424307.1	1	Reactome: R-HSA-69231	"Cyclin D associated events in G1"
XP_046417917.1	13	Reactome: R-HSA-72764;Reactome: R-HSA-975956;Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-975957;Reactome: R-HSA-1799339;Reactome: R-HSA-2408557;Reactome: R-HSA-72706;Reactome: R-HSA-192823;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-72689	"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"Selenocysteine synthesis";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Formation of a pool of free 40S subunits"
XP_046435748.1	2	Reactome: R-HSA-380095;Reactome: R-HSA-416476	"Tachykinin receptors bind tachykinins";"G alpha (q) signalling events"
XP_046428645.1	1	Reactome: R-HSA-525793	"Myogenesis"
XP_046426844.1	2	MetaCyc: PWY-4261;KEGG: 00561+2.7.1.30	"Glycerol degradation I";"Glycerolipid metabolism"
XP_046434628.1	4	Reactome: R-HSA-936440;Reactome: R-HSA-5205685;Reactome: R-HSA-1632852;Reactome: R-HSA-8934903	"Negative regulators of DDX58/IFIH1 signaling";"Pink/Parkin Mediated Mitophagy";"Macroautophagy";"Receptor Mediated Mitophagy"
XP_046430474.1	4	Reactome: R-HSA-3769402;Reactome: R-HSA-2122947;Reactome: R-HSA-201722;Reactome: R-HSA-4641265	"Deactivation of the beta-catenin transactivating complex";"NOTCH1 Intracellular Domain Regulates Transcription";"Formation of the beta-catenin:TCF transactivating complex";"Repression of WNT target genes"
XP_046414967.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_046431088.1	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_046427984.1	2	Reactome: R-HSA-5689880;Reactome: R-HSA-5689603	"Ub-specific processing proteases";"UCH proteinases"
XP_046436303.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_046422259.1	1	Reactome: R-HSA-5656169	"Termination of translesion DNA synthesis"
XP_046415445.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-5628897	"Respiratory electron transport";"TP53 Regulates Metabolic Genes"
XP_046416087.1	2	Reactome: R-HSA-203927;Reactome: R-HSA-8986944	"MicroRNA (miRNA) biogenesis";"Transcriptional Regulation by MECP2"
XP_046414054.1	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
XP_046433764.1	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
XP_046418355.1	5	Reactome: R-HSA-3249367;Reactome: R-HSA-3270619;Reactome: R-HSA-1834941;Reactome: R-HSA-6798695;Reactome: R-HSA-3134975	"STAT6-mediated induction of chemokines";"IRF3-mediated induction of type I IFN";"STING mediated induction of host immune responses";"Neutrophil degranulation";"Regulation of innate immune responses to cytosolic DNA"
XP_046414980.1	13	Reactome: R-HSA-975957;Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-975956;Reactome: R-HSA-72764;Reactome: R-HSA-9633012;Reactome: R-HSA-72689;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-192823;Reactome: R-HSA-72706;Reactome: R-HSA-2408557;Reactome: R-HSA-1799339	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Formation of a pool of free 40S subunits";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Viral mRNA Translation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Selenocysteine synthesis";"SRP-dependent cotranslational protein targeting to membrane"
XP_046430967.1	7	MetaCyc: PWY-6351;KEGG: 04070+2.7.1.67;MetaCyc: PWY-6352;KEGG: 00562+2.7.1.67;Reactome: R-HSA-1660516;Reactome: R-HSA-1660514;Reactome: R-HSA-1660499	"D-myo-inositol (1,4,5)-trisphosphate biosynthesis";"Phosphatidylinositol signaling system";"3-phosphoinositide biosynthesis";"Inositol phosphate metabolism";"Synthesis of PIPs at the early endosome membrane";"Synthesis of PIPs at the Golgi membrane";"Synthesis of PIPs at the plasma membrane"
XP_046409803.1	1	Reactome: R-HSA-425381	"Bicarbonate transporters"
XP_046426735.1	8	Reactome: R-HSA-3371571;Reactome: R-HSA-9639288;Reactome: R-HSA-8943724;Reactome: R-HSA-5628897;Reactome: R-HSA-166208;Reactome: R-HSA-1632852;Reactome: R-HSA-165159;Reactome: R-HSA-380972	"HSF1-dependent transactivation";"Amino acids regulate mTORC1";"Regulation of PTEN gene transcription";"TP53 Regulates Metabolic Genes";"mTORC1-mediated signalling";"Macroautophagy";"mTOR signalling";"Energy dependent regulation of mTOR by LKB1-AMPK"
XP_046425236.1	1	Reactome: R-HSA-418990	"Adherens junctions interactions"
XP_046418145.1	1	Reactome: R-HSA-1445148	"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
XP_046431413.1	2	Reactome: R-HSA-3295583;Reactome: R-HSA-418890	"TRP channels";"Role of second messengers in netrin-1 signaling"
XP_046430092.1	3	KEGG: 00790+2.10.1.1;MetaCyc: PWY-6823;Reactome: R-HSA-947581	"Folate biosynthesis";"Molybdenum cofactor biosynthesis";"Molybdenum cofactor biosynthesis"
XP_046411662.1	2	Reactome: R-HSA-1169408;Reactome: R-HSA-168276	"ISG15 antiviral mechanism";"NS1 Mediated Effects on Host Pathways"
XP_046431663.1	3	Reactome: R-HSA-114608;Reactome: R-HSA-381426;Reactome: R-HSA-8957275	"Platelet degranulation";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"Post-translational protein phosphorylation"
XP_046417494.1	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
XP_046413978.1	8	KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1;Reactome: R-HSA-2028269;KEGG: 04151+2.7.11.1	"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Thermogenesis";"Relaxin signaling pathway";"Human cytomegalovirus infection";"mTOR signaling pathway";"Signaling by Hippo";"PI3K-Akt signaling pathway"
XP_046421348.1	7	KEGG: 04926+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1	"Relaxin signaling pathway";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Human cytomegalovirus infection";"Thermogenesis";"PI3K-Akt signaling pathway";"mTOR signaling pathway"
XP_046436674.1	12	Reactome: R-HSA-9648025;Reactome: R-HSA-141444;Reactome: R-HSA-9609690;Reactome: R-HSA-68877;Reactome: R-HSA-2467813;Reactome: R-HSA-9646399;Reactome: R-HSA-6811436;Reactome: R-HSA-2132295;Reactome: R-HSA-3371497;Reactome: R-HSA-6807878;Reactome: R-HSA-5663220;Reactome: R-HSA-2500257	"EML4 and NUDC in mitotic spindle formation";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"HCMV Early Events";"Mitotic Prometaphase";"Separation of Sister Chromatids";"Aggrephagy";"COPI-independent Golgi-to-ER retrograde traffic";"MHC class II antigen presentation";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-mediated anterograde transport";"RHO GTPases Activate Formins";"Resolution of Sister Chromatid Cohesion"
XP_046436682.1	12	Reactome: R-HSA-68877;Reactome: R-HSA-9609690;Reactome: R-HSA-2467813;Reactome: R-HSA-9646399;Reactome: R-HSA-6811436;Reactome: R-HSA-9648025;Reactome: R-HSA-141444;Reactome: R-HSA-2132295;Reactome: R-HSA-6807878;Reactome: R-HSA-3371497;Reactome: R-HSA-5663220;Reactome: R-HSA-2500257	"Mitotic Prometaphase";"HCMV Early Events";"Separation of Sister Chromatids";"Aggrephagy";"COPI-independent Golgi-to-ER retrograde traffic";"EML4 and NUDC in mitotic spindle formation";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"MHC class II antigen presentation";"COPI-mediated anterograde transport";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"RHO GTPases Activate Formins";"Resolution of Sister Chromatid Cohesion"
XP_046416999.1	1	Reactome: R-HSA-5576886	"Phase 4 - resting membrane potential"
XP_046420501.1	1	Reactome: R-HSA-428359	"Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA"
XP_046410987.1	1	Reactome: R-HSA-6811440	"Retrograde transport at the Trans-Golgi-Network"
XP_046423642.1	52	Reactome: R-HSA-8854050;Reactome: R-HSA-9020702;Reactome: R-HSA-174113;Reactome: R-HSA-5687128;Reactome: R-HSA-5689603;Reactome: R-HSA-68827;Reactome: R-HSA-5607764;Reactome: R-HSA-180534;Reactome: R-HSA-1234176;Reactome: R-HSA-8948751;Reactome: R-HSA-69481;Reactome: R-HSA-8852276;Reactome: R-HSA-5610783;Reactome: R-HSA-1236974;Reactome: R-HSA-5610780;Reactome: R-HSA-450408;Reactome: R-HSA-5632684;Reactome: R-HSA-211733;Reactome: R-HSA-4641258;Reactome: R-HSA-5668541;Reactome: R-HSA-350562;Reactome: R-HSA-9010553;Reactome: R-HSA-69017;Reactome: R-HSA-5358346;Reactome: R-HSA-69601;Reactome: R-HSA-5362768;Reactome: R-HSA-5676590;Reactome: R-HSA-382556;Reactome: R-HSA-68949;Reactome: R-HSA-1169091;Reactome: R-HSA-2871837;Reactome: R-HSA-174178;Reactome: R-HSA-195253;Reactome: R-HSA-8951664;Reactome: R-HSA-5689880;Reactome: R-HSA-349425;Reactome: R-HSA-1236978;Reactome: R-HSA-4608870;Reactome: R-HSA-4641257;Reactome: R-HSA-75815;Reactome: R-HSA-202424;Reactome: R-HSA-180585;Reactome: R-HSA-5678895;Reactome: R-HSA-5610785;Reactome: R-HSA-8939236;Reactome: R-HSA-5607761;Reactome: R-HSA-5658442;Reactome: R-HSA-983168;Reactome: R-HSA-174154;Reactome: R-HSA-174184;Reactome: R-HSA-8939902;Reactome: R-HSA-2467813	"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Interleukin-1 signaling";"SCF-beta-TrCP mediated degradation of Emi1";"MAPK6/MAPK4 signaling";"UCH proteinases";"CDT1 association with the CDC6:ORC:origin complex";"CLEC7A (Dectin-1) signaling";"Vpu mediated degradation of CD4";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of PTEN stability and activity";"G2/M Checkpoints";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Degradation of GLI2 by the proteasome";"ER-Phagosome pathway";"Degradation of GLI1 by the proteasome";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Hedgehog 'on' state";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Degradation of DVL";"TNFR2 non-canonical NF-kB pathway";"Regulation of ornithine decarboxylase (ODC)";"Regulation of expression of SLITs and ROBOs";"CDK-mediated phosphorylation and removal of Cdc6";"Hedgehog ligand biogenesis";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"NIK-->noncanonical NF-kB signaling";"ABC-family proteins mediated transport";"Orc1 removal from chromatin";"Activation of NF-kappaB in B cells";"FCERI mediated NF-kB activation";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Degradation of beta-catenin by the destruction complex";"Neddylation";"Ub-specific processing proteases";"Autodegradation of the E3 ubiquitin ligase COP1";"Cross-presentation of soluble exogenous antigens (endosomes)";"Asymmetric localization of PCP proteins";"Degradation of AXIN";"Ubiquitin-dependent degradation of Cyclin D";"Downstream TCR signaling";"Vif-mediated degradation of APOBEC3G";"Defective CFTR causes cystic fibrosis";"GLI3 is processed to GLI3R by the proteasome";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Dectin-1 mediated noncanonical NF-kB signaling";"Regulation of RAS by GAPs";"Antigen processing: Ubiquitination & Proteasome degradation";"APC/C:Cdc20 mediated degradation of Securin";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Regulation of RUNX2 expression and activity";"Separation of Sister Chromatids"
XP_046430941.1	1	Reactome: R-HSA-8854691	"Interleukin-20 family signaling"
XP_046434168.1	9	Reactome: R-HSA-110330;Reactome: R-HSA-110357;Reactome: R-HSA-110331;Reactome: R-HSA-9630221;Reactome: R-HSA-9608290;Reactome: R-HSA-110328;Reactome: R-HSA-9608287;Reactome: R-HSA-110329;Reactome: R-HSA-9630222	"Recognition and association of DNA glycosylase with site containing an affected purine";"Displacement of DNA glycosylase by APEX1";"Cleavage of the damaged purine";"Defective NTHL1 substrate processing";"Defective MUTYH substrate processing";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"Defective MUTYH substrate binding";"Cleavage of the damaged pyrimidine";"Defective NTHL1 substrate binding"
XP_046413284.1	16	Reactome: R-HSA-8853884;Reactome: R-HSA-5687128;Reactome: R-HSA-9022692;Reactome: R-HSA-426496;Reactome: R-HSA-9029569;Reactome: R-HSA-2559580;Reactome: R-HSA-8934593;Reactome: R-HSA-4086398;Reactome: R-HSA-8936459;Reactome: R-HSA-9018519;Reactome: R-HSA-2559585;Reactome: R-HSA-5628897;Reactome: R-HSA-8948700;Reactome: R-HSA-8943723;Reactome: R-HSA-1912408;Reactome: R-HSA-8986944	"Transcriptional Regulation by VENTX";"MAPK6/MAPK4 signaling";"Regulation of MECP2 expression and activity";"Post-transcriptional silencing by small RNAs";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Oxidative Stress Induced Senescence";"Regulation of RUNX1 Expression and Activity";"Ca2+ pathway";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Estrogen-dependent gene expression";"Oncogene Induced Senescence";"TP53 Regulates Metabolic Genes";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"Regulation of PTEN mRNA translation";"Pre-NOTCH Transcription and Translation";"Transcriptional Regulation by MECP2"
XP_046416062.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_046419066.1	1	Reactome: R-HSA-5658442	"Regulation of RAS by GAPs"
XP_046419389.1	6	MetaCyc: PWY-6733;Reactome: R-HSA-9640463;KEGG: 00073+1.2.1.84;MetaCyc: PWY-7656;MetaCyc: PWY-5884;MetaCyc: PWY-7782	"Sporopollenin precursors biosynthesis";"Wax biosynthesis";"Cutin, suberine and wax biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Wax esters biosynthesis I";"Plasmalogen biosynthesis"
XP_046428862.1	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
XP_046435032.1	1	Reactome: R-HSA-2514853	"Condensation of Prometaphase Chromosomes"
XP_046419148.1	2	Reactome: R-HSA-3214858;Reactome: R-HSA-8939243	"RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"
XP_046434311.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_046427724.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_046423524.1	1	Reactome: R-HSA-1445148	"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
XP_046428143.1	2	Reactome: R-HSA-6784531;Reactome: R-HSA-6791226	"tRNA processing in the nucleus";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046416549.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046429687.1	1	Reactome: R-HSA-388844	"Receptor-type tyrosine-protein phosphatases"
XP_046432160.1	1	Reactome: R-HSA-390522	"Striated Muscle Contraction"
XP_046436672.1	12	Reactome: R-HSA-5663220;Reactome: R-HSA-2500257;Reactome: R-HSA-6807878;Reactome: R-HSA-3371497;Reactome: R-HSA-2132295;Reactome: R-HSA-9609690;Reactome: R-HSA-68877;Reactome: R-HSA-2467813;Reactome: R-HSA-6811436;Reactome: R-HSA-9646399;Reactome: R-HSA-9648025;Reactome: R-HSA-141444	"RHO GTPases Activate Formins";"Resolution of Sister Chromatid Cohesion";"COPI-mediated anterograde transport";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"MHC class II antigen presentation";"HCMV Early Events";"Mitotic Prometaphase";"Separation of Sister Chromatids";"COPI-independent Golgi-to-ER retrograde traffic";"Aggrephagy";"EML4 and NUDC in mitotic spindle formation";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"
XP_046420374.1	3	Reactome: R-HSA-4420097;Reactome: R-HSA-5663213;Reactome: R-HSA-2029482	"VEGFA-VEGFR2 Pathway";"RHO GTPases Activate WASPs and WAVEs";"Regulation of actin dynamics for phagocytic cup formation"
XP_046411111.1	15	Reactome: R-HSA-6804756;Reactome: R-HSA-5693571;Reactome: R-HSA-69473;Reactome: R-HSA-5685939;Reactome: R-HSA-5685938;Reactome: R-HSA-5693616;Reactome: R-HSA-5693554;Reactome: R-HSA-5693568;Reactome: R-HSA-5693579;Reactome: R-HSA-2559586;Reactome: R-HSA-5693565;Reactome: R-HSA-5685942;Reactome: R-HSA-5693548;Reactome: R-HSA-5693607;Reactome: R-HSA-912446	"Regulation of TP53 Activity through Phosphorylation";"Nonhomologous End-Joining (NHEJ)";"G2/M DNA damage checkpoint";"HDR through MMEJ (alt-NHEJ)";"HDR through Single Strand Annealing (SSA)";"Presynaptic phase of homologous DNA pairing and strand exchange";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Resolution of D-loop Structures through Holliday Junction Intermediates";"Homologous DNA Pairing and Strand Exchange";"DNA Damage/Telomere Stress Induced Senescence";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"HDR through Homologous Recombination (HRR)";"Sensing of DNA Double Strand Breaks";"Processing of DNA double-strand break ends";"Meiotic recombination"
XP_046433526.1	1	Reactome: R-HSA-5620912	"Anchoring of the basal body to the plasma membrane"
XP_046418182.1	1	Reactome: R-HSA-532668	"N-glycan trimming in the ER and Calnexin/Calreticulin cycle"
XP_046428803.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_046409382.1	1	Reactome: R-HSA-5620912	"Anchoring of the basal body to the plasma membrane"
XP_046424590.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046417029.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046425597.1	1	Reactome: R-HSA-6811434	"COPI-dependent Golgi-to-ER retrograde traffic"
XP_046423339.1	2	Reactome: R-HSA-180024;KEGG: 00230+3.1.4.53	"DARPP-32 events";"Purine metabolism"
XP_046430186.1	2	Reactome: R-HSA-2032785;Reactome: R-HSA-8951671	"YAP1- and WWTR1 (TAZ)-stimulated gene expression";"RUNX3 regulates YAP1-mediated transcription"
XP_046425302.1	15	Reactome: R-HSA-167246;Reactome: R-HSA-75955;Reactome: R-HSA-6807505;Reactome: R-HSA-167238;Reactome: R-HSA-2173796;Reactome: R-HSA-167243;Reactome: R-HSA-112382;Reactome: R-HSA-167287;Reactome: R-HSA-176034;Reactome: R-HSA-167200;Reactome: R-HSA-6796648;Reactome: R-HSA-674695;Reactome: R-HSA-167152;Reactome: R-HSA-9018519;Reactome: R-HSA-167290	"Tat-mediated elongation of the HIV-1 transcript";"RNA Polymerase II Transcription Elongation";"RNA polymerase II transcribes snRNA genes";"Pausing and recovery of Tat-mediated HIV elongation";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"Tat-mediated HIV elongation arrest and recovery";"Formation of RNA Pol II elongation complex";"HIV elongation arrest and recovery";"Interactions of Tat with host cellular proteins";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Pre-transcription Events";"Formation of HIV elongation complex in the absence of HIV Tat";"Estrogen-dependent gene expression";"Pausing and recovery of HIV elongation"
XP_046421004.1	1	Reactome: R-HSA-432047	"Passive transport by Aquaporins"
XP_046410088.1	13	Reactome: R-HSA-168638;Reactome: R-HSA-975163;Reactome: R-HSA-9020702;Reactome: R-HSA-9645460;Reactome: R-HSA-450321;Reactome: R-HSA-937042;Reactome: R-HSA-2871837;Reactome: R-HSA-450302;Reactome: R-HSA-9014325;Reactome: R-HSA-5607764;Reactome: R-HSA-5357956;Reactome: R-HSA-445989;Reactome: R-HSA-937072	"NOD1/2 Signaling Pathway";"IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation";"Interleukin-1 signaling";"Alpha-protein kinase 1 signaling pathway";"JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1";"IRAK2 mediated activation of TAK1 complex";"FCERI mediated NF-kB activation";"activated TAK1 mediates p38 MAPK activation";"TICAM1,TRAF6-dependent induction of TAK1 complex";"CLEC7A (Dectin-1) signaling";"TNFR1-induced NFkappaB signaling pathway";"TAK1 activates NFkB by phosphorylation and activation of IKKs complex";"TRAF6-mediated induction of TAK1 complex within TLR4 complex"
XP_046409686.1	1	Reactome: R-HSA-112126	"ALKBH3 mediated reversal of alkylation damage"
XP_046421971.1	2	Reactome: R-HSA-1296052;Reactome: R-HSA-418457	"Ca2+ activated K+ channels";"cGMP effects"
XP_046423291.1	2	Reactome: R-HSA-8949613;Reactome: R-HSA-1268020	"Cristae formation";"Mitochondrial protein import"
XP_046417737.1	2	Reactome: R-HSA-416993;Reactome: R-HSA-202733	"Trafficking of GluR2-containing AMPA receptors";"Cell surface interactions at the vascular wall"
XP_046417685.1	1	KEGG: 00970+6.1.1.3	"Aminoacyl-tRNA biosynthesis"
XP_046420623.1	1	Reactome: R-HSA-525793	"Myogenesis"
XP_046427912.1	6	KEGG: 04070+2.7.1.107;KEGG: 00564+2.7.1.107;Reactome: R-HSA-114508;MetaCyc: PWY-7817;MetaCyc: PWY-7039;KEGG: 00561+2.7.1.107	"Phosphatidylinositol signaling system";"Glycerophospholipid metabolism";"Effects of PIP2 hydrolysis";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Phosphatidate metabolism, as a signaling molecule";"Glycerolipid metabolism"
XP_046429523.1	2	Reactome: R-HSA-8876198;Reactome: R-HSA-5357905	"RAB GEFs exchange GTP for GDP on RABs";"Regulation of TNFR1 signaling"
XP_046429984.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_046435783.1	12	Reactome: R-HSA-380270;Reactome: R-HSA-3371497;Reactome: R-HSA-6807878;Reactome: R-HSA-8854518;Reactome: R-HSA-5620912;Reactome: R-HSA-2565942;Reactome: R-HSA-380320;Reactome: R-HSA-380259;Reactome: R-HSA-6811436;Reactome: R-HSA-381038;Reactome: R-HSA-380284;Reactome: R-HSA-2132295	"Recruitment of mitotic centrosome proteins and complexes";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-mediated anterograde transport";"AURKA Activation by TPX2";"Anchoring of the basal body to the plasma membrane";"Regulation of PLK1 Activity at G2/M Transition";"Recruitment of NuMA to mitotic centrosomes";"Loss of Nlp from mitotic centrosomes";"COPI-independent Golgi-to-ER retrograde traffic";"XBP1(S) activates chaperone genes";"Loss of proteins required for interphase microtubule organization from the centrosome";"MHC class II antigen presentation"
XP_046431677.1	13	MetaCyc: PWY-6902;KEGG: 00513+3.2.1.52;MetaCyc: PWY-7822;Reactome: R-HSA-2160916;KEGG: 00531+3.2.1.52;KEGG: 00520+3.2.1.52;Reactome: R-HSA-2024101;Reactome: R-HSA-1660662;MetaCyc: PWY-7883;Reactome: R-HSA-2022857;KEGG: 00604+3.2.1.52;KEGG: 00511+3.2.1.52;KEGG: 00603+3.2.1.52	"Chitin degradation II (Vibrio)";"Various types of N-glycan biosynthesis";"Chitin degradation III (Serratia)";"Hyaluronan uptake and degradation";"Glycosaminoglycan degradation";"Amino sugar and nucleotide sugar metabolism";"CS/DS degradation";"Glycosphingolipid metabolism";"Anhydromuropeptides recycling II";"Keratan sulfate degradation";"Glycosphingolipid biosynthesis - ganglio series";"Other glycan degradation";"Glycosphingolipid biosynthesis - globo and isoglobo series"
XP_046418830.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046424994.1	1	Reactome: R-HSA-1483101	"Synthesis of PS"
XP_046420714.1	14	MetaCyc: PWY-7035;MetaCyc: PWY-7602;MetaCyc: PWY-6598;MetaCyc: PWY-7036;MetaCyc: PWY-8041;MetaCyc: PWY-7601;KEGG: 00062+2.3.1.199;MetaCyc: PWY-5080;MetaCyc: PWY-7725;MetaCyc: PWY-7619;Reactome: R-HSA-75876;MetaCyc: PWY-5972;MetaCyc: PWY-7724;MetaCyc: PWY-6433	"(9Z)-tricosene biosynthesis";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Sciadonate biosynthesis";"Very long chain fatty acid biosynthesis II";"Ultra-long-chain fatty acid biosynthesis";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Fatty acid elongation";"Very long chain fatty acid biosynthesis I";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Juniperonate biosynthesis";"Synthesis of very long-chain fatty acyl-CoAs";"Stearate biosynthesis I (animals)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Hydroxylated fatty acid biosynthesis (plants)"
XP_046414490.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046433012.1	7	Reactome: R-HSA-1362300;Reactome: R-HSA-156711;Reactome: R-HSA-69656;Reactome: R-HSA-69202;Reactome: R-HSA-1538133;Reactome: R-HSA-1362277;Reactome: R-HSA-69205	"Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1";"Polo-like kinase mediated events";"Cyclin A:Cdk2-associated events at S phase entry";"Cyclin E associated events during G1/S transition";"G0 and Early G1";"Transcription of E2F targets under negative control by DREAM complex";"G1/S-Specific Transcription"
XP_046430665.1	1	Reactome: R-HSA-6794361	"Neurexins and neuroligins"
XP_046427321.1	2	Reactome: R-HSA-8856828;Reactome: R-HSA-8856825	"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis"
XP_046425954.1	1	Reactome: R-HSA-9037629	"Lewis blood group biosynthesis"
XP_046417740.1	2	Reactome: R-HSA-416993;Reactome: R-HSA-202733	"Trafficking of GluR2-containing AMPA receptors";"Cell surface interactions at the vascular wall"
XP_046419863.1	19	Reactome: R-HSA-5578775;Reactome: R-HSA-399719;Reactome: R-HSA-936837;Reactome: R-HSA-9609736;Reactome: R-HSA-9617324;Reactome: R-HSA-877300;Reactome: R-HSA-5576892;Reactome: R-HSA-9022692;Reactome: R-HSA-111932;Reactome: R-HSA-438066;Reactome: R-HSA-6802955;Reactome: R-HSA-6802952;Reactome: R-HSA-9649948;Reactome: R-HSA-3371571;Reactome: R-HSA-442982;Reactome: R-HSA-9620244;Reactome: R-HSA-6802946;Reactome: R-HSA-5673000;Reactome: R-HSA-5673001	"Ion homeostasis";"Trafficking of AMPA receptors";"Ion transport by P-type ATPases";"Assembly and cell surface presentation of NMDA receptors";"Negative regulation of NMDA receptor-mediated neuronal transmission";"Interferon gamma signaling";"Phase 0 - rapid depolarisation";"Regulation of MECP2 expression and activity";"CaMK IV-mediated phosphorylation of CREB";"Unblocking of NMDA receptors, glutamate binding and activation";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"Signaling by BRAF and RAF fusions";"Signaling downstream of RAS mutants";"HSF1-dependent transactivation";"Ras activation upon Ca2+ influx through NMDA receptor";"Long-term potentiation";"Signaling by moderate kinase activity BRAF mutants";"RAF activation";"RAF/MAP kinase cascade"
XP_046429829.1	2	Reactome: R-HSA-5635838;Reactome: R-HSA-5632681	"Activation of SMO";"Ligand-receptor interactions"
XP_046423594.1	6	KEGG: 04070+3.1.3.56;MetaCyc: PWY-6363;KEGG: 00562+3.1.3.56;MetaCyc: PWY-6362;Reactome: R-HSA-1855183;MetaCyc: PWY-6364	"Phosphatidylinositol signaling system";"D-myo-inositol (1,4,5)-trisphosphate degradation";"Inositol phosphate metabolism";"1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)";"Synthesis of IP2, IP, and Ins in the cytosol";"D-myo-inositol (1,3,4)-trisphosphate biosynthesis"
XP_046422006.1	5	Reactome: R-HSA-5617472;Reactome: R-HSA-3769402;Reactome: R-HSA-201722;Reactome: R-HSA-8936459;Reactome: R-HSA-3214841	"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Deactivation of the beta-catenin transactivating complex";"Formation of the beta-catenin:TCF transactivating complex";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"PKMTs methylate histone lysines"
XP_046435903.1	2	Reactome: R-HSA-6807878;Reactome: R-HSA-445095	"COPI-mediated anterograde transport";"Interaction between L1 and Ankyrins"
XP_046430807.1	5	Reactome: R-HSA-8943724;Reactome: R-HSA-3214815;Reactome: R-HSA-73762;Reactome: R-HSA-427389;Reactome: R-HSA-6804758	"Regulation of PTEN gene transcription";"HDACs deacetylate histones";"RNA Polymerase I Transcription Initiation";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"Regulation of TP53 Activity through Acetylation"
XP_046430374.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046431082.1	4	Reactome: R-HSA-201722;Reactome: R-HSA-2122947;Reactome: R-HSA-4641265;Reactome: R-HSA-3769402	"Formation of the beta-catenin:TCF transactivating complex";"NOTCH1 Intracellular Domain Regulates Transcription";"Repression of WNT target genes";"Deactivation of the beta-catenin transactivating complex"
XP_046413193.1	7	KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1	"Relaxin signaling pathway";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Human cytomegalovirus infection";"Thermogenesis";"PI3K-Akt signaling pathway";"mTOR signaling pathway"
XP_046413964.1	2	Reactome: R-HSA-1912399;KEGG: 00514+2.4.1.221	"Pre-NOTCH Processing in the Endoplasmic Reticulum";"Other types of O-glycan biosynthesis"
XP_046422288.1	3	KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway"
XP_046419152.1	2	Reactome: R-HSA-3214858;Reactome: R-HSA-8939243	"RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"
XP_046427826.1	1	Reactome: R-HSA-429958	"mRNA decay by 3' to 5' exoribonuclease"
XP_046420280.1	4	MetaCyc: PWY-7822;MetaCyc: PWY-6902;MetaCyc: PWY-6855;KEGG: 00520+3.2.1.14	"Chitin degradation III (Serratia)";"Chitin degradation II (Vibrio)";"Chitin degradation I (archaea)";"Amino sugar and nucleotide sugar metabolism"
XP_046435009.1	2	Reactome: R-HSA-163282;Reactome: R-HSA-2151201	"Mitochondrial transcription initiation";"Transcriptional activation of mitochondrial biogenesis"
XP_046417981.1	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
XP_046416826.1	14	KEGG: 00591+3.1.1.4;MetaCyc: PWY-7417;MetaCyc: PWY-7409;MetaCyc: PWY-8053;MetaCyc: PWY-7416;Reactome: R-HSA-975634;KEGG: 00590+3.1.1.4;MetaCyc: PWY-7783;KEGG: 00592+3.1.1.4;KEGG: 00564+3.1.1.4+3.1.1.5;MetaCyc: PWY-8051;MetaCyc: PWY-6803;Reactome: R-HSA-1482788;KEGG: 00565+3.1.1.4	"Linoleic acid metabolism";"Phospholipid remodeling (phosphatidate, yeast)";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Anandamide biosynthesis II";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Retinoid metabolism and transport";"Arachidonic acid metabolism";"Plasmalogen degradation";"alpha-Linolenic acid metabolism";"Glycerophospholipid metabolism";"Anandamide biosynthesis I";"Phosphatidylcholine acyl editing";"Acyl chain remodelling of PC";"Ether lipid metabolism"
XP_046434809.1	1	Reactome: R-HSA-2132295	"MHC class II antigen presentation"
XP_046434289.1	4	MetaCyc: PWY-3722;MetaCyc: PWY-7494;KEGG: 00260+1.2.1.8+1.1.99.1;Reactome: R-HSA-6798163	"Glycine betaine biosynthesis II (Gram-positive bacteria)";"Choline degradation IV";"Glycine, serine and threonine metabolism";"Choline catabolism"
XP_046431044.1	3	KEGG: 00230+2.7.4.8;MetaCyc: PWY-7221;Reactome: R-HSA-420029	"Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis";"Tight junction interactions"
XP_046426137.1	10	MetaCyc: PWY-6361;Reactome: R-HSA-1855167;Reactome: R-HSA-1855191;MetaCyc: PWY-6554;KEGG: 00562+2.7.1.158;MetaCyc: PWY-6362;MetaCyc: PWY-6369;MetaCyc: PWY-4661;KEGG: 04070+2.7.1.158;MetaCyc: PWY-6372	"1D-myo-inositol hexakisphosphate biosynthesis I (from Ins(1,4,5)P3)";"Synthesis of pyrophosphates in the cytosol";"Synthesis of IPs in the nucleus";"1D-myo-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3)";"Inositol phosphate metabolism";"1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)";"Inositol diphosphates biosynthesis";"1D-myo-inositol hexakisphosphate biosynthesis III (Spirodela polyrrhiza)";"Phosphatidylinositol signaling system";"1D-myo-inositol hexakisphosphate biosynthesis IV (Dictyostelium)"
XP_046433684.1	4	Reactome: R-HSA-5696395;Reactome: R-HSA-6782135;Reactome: R-HSA-6781823;Reactome: R-HSA-5696400	"Formation of Incision Complex in GG-NER";"Dual incision in TC-NER";"Formation of TC-NER Pre-Incision Complex";"Dual Incision in GG-NER"
XP_046434483.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046433682.1	1	Reactome: R-HSA-69273	"Cyclin A/B1/B2 associated events during G2/M transition"
XP_046432704.1	1	Reactome: R-HSA-381753	"Olfactory Signaling Pathway"
XP_046431080.1	4	Reactome: R-HSA-2122947;Reactome: R-HSA-201722;Reactome: R-HSA-4641265;Reactome: R-HSA-3769402	"NOTCH1 Intracellular Domain Regulates Transcription";"Formation of the beta-catenin:TCF transactivating complex";"Repression of WNT target genes";"Deactivation of the beta-catenin transactivating complex"
XP_046429926.1	1	Reactome: R-HSA-8873719	"RAB geranylgeranylation"
XP_046419509.1	3	Reactome: R-HSA-3000157;Reactome: R-HSA-3000171;Reactome: R-HSA-8874081	"Laminin interactions";"Non-integrin membrane-ECM interactions";"MET activates PTK2 signaling"
XP_046431150.1	14	MetaCyc: PWY-7589;MetaCyc: PWY-7782;MetaCyc: PWY-8053;MetaCyc: PWY-5981;MetaCyc: PWY-7417;KEGG: 00561+2.3.1.51;MetaCyc: PWY-8055;MetaCyc: PWY-6453;MetaCyc: PWY-8051;KEGG: 00564+2.3.1.51;MetaCyc: PWY-5667;MetaCyc: PWY-7411;Reactome: R-HSA-1483166;MetaCyc: PWY-7587	"Palmitoleate biosynthesis III (cyanobacteria)";"Plasmalogen biosynthesis";"Anandamide biosynthesis II";"CDP-diacylglycerol biosynthesis III";"Phospholipid remodeling (phosphatidate, yeast)";"Glycerolipid metabolism";"Palmitoyl ethanolamide biosynthesis";"Stigma estolide biosynthesis";"Anandamide biosynthesis I";"Glycerophospholipid metabolism";"CDP-diacylglycerol biosynthesis I";"Phosphatidate biosynthesis (yeast)";"Synthesis of PA";"Oleate biosynthesis III (cyanobacteria)"
XP_046415339.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046415197.1	1	Reactome: R-HSA-420499	"Class C/3 (Metabotropic glutamate/pheromone receptors)"
XP_046435269.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_046435776.1	1	Reactome: R-HSA-390651	"Dopamine receptors"
XP_046413516.1	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
XP_046429451.1	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
XP_046435062.1	7	KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1	"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Human cytomegalovirus infection";"Thermogenesis";"Relaxin signaling pathway";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection"
XP_046436563.1	9	Reactome: R-HSA-3656535;Reactome: R-HSA-3304356;Reactome: R-HSA-3656532;Reactome: R-HSA-2173791;Reactome: R-HSA-2173789;Reactome: R-HSA-5689603;Reactome: R-HSA-2173788;Reactome: R-HSA-3642279;Reactome: R-HSA-3645790	"TGFBR1 LBD Mutants in Cancer";"SMAD2/3 Phosphorylation Motif Mutants in Cancer";"TGFBR1 KD Mutants in Cancer";"TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)";"TGF-beta receptor signaling activates SMADs";"UCH proteinases";"Downregulation of TGF-beta receptor signaling";"TGFBR2 MSI Frameshift Mutants in Cancer";"TGFBR2 Kinase Domain Mutants in Cancer"
XP_046422858.1	1	Reactome: R-HSA-426048	"Arachidonate production from DAG"
XP_046430976.1	6	Reactome: R-HSA-8964539;MetaCyc: PWY-3341;KEGG: 00330+2.6.1.13;MetaCyc: PWY-6344;MetaCyc: PWY-6922;MetaCyc: PWY-4981	"Glutamate and glutamine metabolism";"L-proline biosynthesis III (from L-ornithine)";"Arginine and proline metabolism";"L-ornithine degradation II (Stickland reaction)";"L-Ndelta-acetylornithine biosynthesis";"L-proline biosynthesis II (from arginine)"
XP_046425521.1	2	Reactome: R-HSA-380270;Reactome: R-HSA-380320	"Recruitment of mitotic centrosome proteins and complexes";"Recruitment of NuMA to mitotic centrosomes"
XP_046434118.1	4	MetaCyc: PWY-5188;KEGG: 00860+2.5.1.61;Reactome: R-HSA-189451;MetaCyc: PWY-5189	"Tetrapyrrole biosynthesis I (from glutamate)";"Porphyrin and chlorophyll metabolism";"Heme biosynthesis";"Tetrapyrrole biosynthesis II (from glycine)"
XP_046423335.1	2	KEGG: 00230+3.1.4.53;Reactome: R-HSA-180024	"Purine metabolism";"DARPP-32 events"
XP_046433653.1	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_046423246.1	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
XP_046421898.1	3	MetaCyc: PWY-7856;Reactome: R-HSA-189451;KEGG: 00860+2.5.1.141	"Heme a biosynthesis";"Heme biosynthesis";"Porphyrin and chlorophyll metabolism"
XP_046425616.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046436225.1	3	Reactome: R-HSA-5620916;Reactome: R-HSA-264876;Reactome: R-HSA-1445148	"VxPx cargo-targeting to cilium";"Insulin processing";"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
XP_046427697.1	6	Reactome: R-HSA-9022692;Reactome: R-HSA-9609690;Reactome: R-HSA-1989781;Reactome: R-HSA-3214815;Reactome: R-HSA-9022537;Reactome: R-HSA-9029569	"Regulation of MECP2 expression and activity";"HCMV Early Events";"PPARA activates gene expression";"HDACs deacetylate histones";"Loss of MECP2 binding ability to the NCoR/SMRT complex";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux"
XP_046432445.1	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
XP_046435882.1	3	Reactome: R-HSA-8963901;Reactome: R-HSA-6807878;Reactome: R-HSA-445095	"Chylomicron remodeling";"COPI-mediated anterograde transport";"Interaction between L1 and Ankyrins"
XP_046434582.1	3	KEGG: 04070+2.7.11.13;Reactome: R-HSA-418597;Reactome: R-HSA-114508	"Phosphatidylinositol signaling system";"G alpha (z) signalling events";"Effects of PIP2 hydrolysis"
XP_046425849.1	1	Reactome: R-HSA-71064	"Lysine catabolism"
XP_046421351.1	1	Reactome: R-HSA-9037629	"Lewis blood group biosynthesis"
XP_046413385.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_046420038.1	19	Reactome: R-HSA-6802955;Reactome: R-HSA-6802952;Reactome: R-HSA-9649948;Reactome: R-HSA-3371571;Reactome: R-HSA-442982;Reactome: R-HSA-9620244;Reactome: R-HSA-6802946;Reactome: R-HSA-5673000;Reactome: R-HSA-5673001;Reactome: R-HSA-399719;Reactome: R-HSA-5578775;Reactome: R-HSA-936837;Reactome: R-HSA-9609736;Reactome: R-HSA-9617324;Reactome: R-HSA-877300;Reactome: R-HSA-5576892;Reactome: R-HSA-111932;Reactome: R-HSA-9022692;Reactome: R-HSA-438066	"Paradoxical activation of RAF signaling by kinase inactive BRAF";"Signaling by BRAF and RAF fusions";"Signaling downstream of RAS mutants";"HSF1-dependent transactivation";"Ras activation upon Ca2+ influx through NMDA receptor";"Long-term potentiation";"Signaling by moderate kinase activity BRAF mutants";"RAF activation";"RAF/MAP kinase cascade";"Trafficking of AMPA receptors";"Ion homeostasis";"Ion transport by P-type ATPases";"Assembly and cell surface presentation of NMDA receptors";"Negative regulation of NMDA receptor-mediated neuronal transmission";"Interferon gamma signaling";"Phase 0 - rapid depolarisation";"CaMK IV-mediated phosphorylation of CREB";"Regulation of MECP2 expression and activity";"Unblocking of NMDA receptors, glutamate binding and activation"
XP_046417077.1	4	Reactome: R-HSA-351202;MetaCyc: PWY-6834;KEGG: 00270+4.1.1.50;KEGG: 00330+4.1.1.50	"Metabolism of polyamines";"Spermidine biosynthesis III";"Cysteine and methionine metabolism";"Arginine and proline metabolism"
XP_046434025.1	1	Reactome: R-HSA-1296061	"HCN channels"
XP_046432150.1	1	Reactome: R-HSA-5368286	"Mitochondrial translation initiation"
XP_046414197.1	1	Reactome: R-HSA-5620912	"Anchoring of the basal body to the plasma membrane"
XP_046433858.1	1	Reactome: R-HSA-5662702	"Melanin biosynthesis"
XP_046414181.1	3	Reactome: R-HSA-196783;KEGG: 00770+2.7.1.33;MetaCyc: PWY-3961	"Coenzyme A biosynthesis";"Pantothenate and CoA biosynthesis";"Phosphopantothenate biosynthesis II"
XP_046434811.1	1	Reactome: R-HSA-3214815	"HDACs deacetylate histones"
XP_046429124.1	2	Reactome: R-HSA-6807505;Reactome: R-HSA-72163	"RNA polymerase II transcribes snRNA genes";"mRNA Splicing - Major Pathway"
XP_046436722.1	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
XP_046434972.1	5	Reactome: R-HSA-6782210;Reactome: R-HSA-72163;Reactome: R-HSA-6781827;Reactome: R-HSA-6782135;Reactome: R-HSA-6781823	"Gap-filling DNA repair synthesis and ligation in TC-NER";"mRNA Splicing - Major Pathway";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Dual incision in TC-NER";"Formation of TC-NER Pre-Incision Complex"
XP_046417187.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046420042.1	3	Reactome: R-HSA-8866654;Reactome: R-HSA-110314;MetaCyc: PWY-7511	"E3 ubiquitin ligases ubiquitinate target proteins";"Recognition of DNA damage by PCNA-containing replication complex";"Protein ubiquitination"
XP_046424290.1	2	Reactome: R-HSA-2142700;Reactome: R-HSA-2142691	"Synthesis of Lipoxins (LX)";"Synthesis of Leukotrienes (LT) and Eoxins (EX)"
XP_046413004.1	1	Reactome: R-HSA-379726	"Mitochondrial tRNA aminoacylation"
XP_046423687.1	11	Reactome: R-HSA-5656169;Reactome: R-HSA-5696400;Reactome: R-HSA-6782135;Reactome: R-HSA-174430;Reactome: R-HSA-5651801;Reactome: R-HSA-68962;Reactome: R-HSA-5696397;Reactome: R-HSA-110314;Reactome: R-HSA-5685942;Reactome: R-HSA-68952;Reactome: R-HSA-6782210	"Termination of translesion DNA synthesis";"Dual Incision in GG-NER";"Dual incision in TC-NER";"Telomere C-strand synthesis initiation";"PCNA-Dependent Long Patch Base Excision Repair";"Activation of the pre-replicative complex";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Recognition of DNA damage by PCNA-containing replication complex";"HDR through Homologous Recombination (HRR)";"DNA replication initiation";"Gap-filling DNA repair synthesis and ligation in TC-NER"
XP_046423995.1	1	Reactome: R-HSA-901032	"ER Quality Control Compartment (ERQC)"
XP_046427568.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046419499.1	3	Reactome: R-HSA-8874081;Reactome: R-HSA-3000171;Reactome: R-HSA-3000157	"MET activates PTK2 signaling";"Non-integrin membrane-ECM interactions";"Laminin interactions"
XP_046422969.1	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
XP_046433024.1	10	Reactome: R-HSA-2894862;Reactome: R-HSA-2197563;Reactome: R-HSA-9013695;Reactome: R-HSA-8941856;Reactome: R-HSA-1912408;Reactome: R-HSA-210744;Reactome: R-HSA-2122947;Reactome: R-HSA-2644606;Reactome: R-HSA-9013508;Reactome: R-HSA-350054	"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"NOTCH2 intracellular domain regulates transcription";"NOTCH4 Intracellular Domain Regulates Transcription";"RUNX3 regulates NOTCH signaling";"Pre-NOTCH Transcription and Translation";"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"NOTCH1 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH3 Intracellular Domain Regulates Transcription";"Notch-HLH transcription pathway"
XP_046422863.1	1	Reactome: R-HSA-426048	"Arachidonate production from DAG"
XP_046431652.1	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
XP_046422373.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046409749.1	1	Reactome: R-HSA-380320	"Recruitment of NuMA to mitotic centrosomes"
XP_046430968.1	7	MetaCyc: PWY-6351;KEGG: 04070+2.7.1.67;MetaCyc: PWY-6352;Reactome: R-HSA-1660516;Reactome: R-HSA-1660499;Reactome: R-HSA-1660514;KEGG: 00562+2.7.1.67	"D-myo-inositol (1,4,5)-trisphosphate biosynthesis";"Phosphatidylinositol signaling system";"3-phosphoinositide biosynthesis";"Synthesis of PIPs at the early endosome membrane";"Synthesis of PIPs at the plasma membrane";"Synthesis of PIPs at the Golgi membrane";"Inositol phosphate metabolism"
XP_046416736.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_046431600.1	1	Reactome: R-HSA-6804760	"Regulation of TP53 Activity through Methylation"
XP_046418307.1	1	Reactome: R-HSA-211945	"Phase I - Functionalization of compounds"
XP_046432963.1	1	Reactome: R-HSA-435368	"Zinc efflux and compartmentalization by the SLC30 family"
XP_046431191.1	56	Reactome: R-HSA-1236978;Reactome: R-HSA-4608870;Reactome: R-HSA-4641257;Reactome: R-HSA-202424;Reactome: R-HSA-75815;Reactome: R-HSA-5689880;Reactome: R-HSA-174084;Reactome: R-HSA-8951664;Reactome: R-HSA-349425;Reactome: R-HSA-8939236;Reactome: R-HSA-5678895;Reactome: R-HSA-180585;Reactome: R-HSA-5610785;Reactome: R-HSA-5607761;Reactome: R-HSA-5658442;Reactome: R-HSA-983168;Reactome: R-HSA-2467813;Reactome: R-HSA-174154;Reactome: R-HSA-174184;Reactome: R-HSA-8939902;Reactome: R-HSA-174113;Reactome: R-HSA-5687128;Reactome: R-HSA-9020702;Reactome: R-HSA-8854050;Reactome: R-HSA-1234176;Reactome: R-HSA-8948751;Reactome: R-HSA-69481;Reactome: R-HSA-8852276;Reactome: R-HSA-5610783;Reactome: R-HSA-5689603;Reactome: R-HSA-68827;Reactome: R-HSA-5607764;Reactome: R-HSA-187577;Reactome: R-HSA-180534;Reactome: R-HSA-5668541;Reactome: R-HSA-9010553;Reactome: R-HSA-8941858;Reactome: R-HSA-350562;Reactome: R-HSA-1236974;Reactome: R-HSA-450408;Reactome: R-HSA-5610780;Reactome: R-HSA-5632684;Reactome: R-HSA-211733;Reactome: R-HSA-4641258;Reactome: R-HSA-382556;Reactome: R-HSA-68949;Reactome: R-HSA-1169091;Reactome: R-HSA-2871837;Reactome: R-HSA-174178;Reactome: R-HSA-195253;Reactome: R-HSA-69017;Reactome: R-HSA-69601;Reactome: R-HSA-5358346;Reactome: R-HSA-5676590;Reactome: R-HSA-5362768;Reactome: R-HSA-9604323	"Cross-presentation of soluble exogenous antigens (endosomes)";"Asymmetric localization of PCP proteins";"Degradation of AXIN";"Downstream TCR signaling";"Ubiquitin-dependent degradation of Cyclin D";"Ub-specific processing proteases";"Autodegradation of Cdh1 by Cdh1:APC/C";"Neddylation";"Autodegradation of the E3 ubiquitin ligase COP1";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Defective CFTR causes cystic fibrosis";"Vif-mediated degradation of APOBEC3G";"GLI3 is processed to GLI3R by the proteasome";"Dectin-1 mediated noncanonical NF-kB signaling";"Regulation of RAS by GAPs";"Antigen processing: Ubiquitination & Proteasome degradation";"Separation of Sister Chromatids";"APC/C:Cdc20 mediated degradation of Securin";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Regulation of RUNX2 expression and activity";"SCF-beta-TrCP mediated degradation of Emi1";"MAPK6/MAPK4 signaling";"Interleukin-1 signaling";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of PTEN stability and activity";"G2/M Checkpoints";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Degradation of GLI2 by the proteasome";"UCH proteinases";"CDT1 association with the CDC6:ORC:origin complex";"CLEC7A (Dectin-1) signaling";"SCF(Skp2)-mediated degradation of p27/p21";"Vpu mediated degradation of CD4";"TNFR2 non-canonical NF-kB pathway";"Regulation of expression of SLITs and ROBOs";"Regulation of RUNX3 expression and activity";"Regulation of ornithine decarboxylase (ODC)";"ER-Phagosome pathway";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Degradation of GLI1 by the proteasome";"Hedgehog 'on' state";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Degradation of DVL";"ABC-family proteins mediated transport";"Orc1 removal from chromatin";"Activation of NF-kappaB in B cells";"FCERI mediated NF-kB activation";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Degradation of beta-catenin by the destruction complex";"CDK-mediated phosphorylation and removal of Cdc6";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Hedgehog ligand biogenesis";"NIK-->noncanonical NF-kB signaling";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Negative regulation of NOTCH4 signaling"
XP_046434978.1	1	Reactome: R-HSA-390651	"Dopamine receptors"
XP_046412355.1	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
XP_046424502.1	9	MetaCyc: PWY-5744;MetaCyc: PWY-7117;MetaCyc: PWY-5743;MetaCyc: PWY-7115;Reactome: R-HSA-1475029;KEGG: 00910+4.2.1.1;MetaCyc: PWY-241;MetaCyc: PWY-5789;MetaCyc: PWY-6142	"Glyoxylate assimilation";"C4 photosynthetic carbon assimilation cycle, PEPCK type";"3-hydroxypropanoate cycle";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"Reversible hydration of carbon dioxide";"Nitrogen metabolism";"C4 photosynthetic carbon assimilation cycle, NADP-ME type";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)"
XP_046414627.1	4	Reactome: R-HSA-350054;Reactome: R-HSA-2644606;Reactome: R-HSA-2894862;Reactome: R-HSA-2122947	"Notch-HLH transcription pathway";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"NOTCH1 Intracellular Domain Regulates Transcription"
XP_046411756.1	1	KEGG: 00480+3.4.11.2	"Glutathione metabolism"
XP_046429770.1	3	Reactome: R-HSA-159230;Reactome: R-HSA-73856;Reactome: R-HSA-77588	"Transport of the SLBP Dependant Mature mRNA";"RNA Polymerase II Transcription Termination";"SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs"
XP_046430421.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046430088.1	3	MetaCyc: PWY-6823;KEGG: 00790+2.10.1.1;Reactome: R-HSA-947581	"Molybdenum cofactor biosynthesis";"Folate biosynthesis";"Molybdenum cofactor biosynthesis"
XP_046411751.1	1	KEGG: 00480+3.4.11.2	"Glutathione metabolism"
XP_046412400.1	13	Reactome: R-HSA-8964038;Reactome: R-HSA-167590;Reactome: R-HSA-182218;Reactome: R-HSA-177504;Reactome: R-HSA-8866427;Reactome: R-HSA-8856828;Reactome: R-HSA-2132295;Reactome: R-HSA-8856825;Reactome: R-HSA-5099900;Reactome: R-HSA-5140745;Reactome: R-HSA-3928665;Reactome: R-HSA-416993;Reactome: R-HSA-437239	"LDL clearance";"Nef Mediated CD4 Down-regulation";"Nef Mediated CD8 Down-regulation";"Retrograde neurotrophin signalling";"VLDLR internalisation and degradation";"Clathrin-mediated endocytosis";"MHC class II antigen presentation";"Cargo recognition for clathrin-mediated endocytosis";"WNT5A-dependent internalization of FZD4";"WNT5A-dependent internalization of FZD2, FZD5 and ROR2";"EPH-ephrin mediated repulsion of cells";"Trafficking of GluR2-containing AMPA receptors";"Recycling pathway of L1"
XP_046429920.1	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
XP_046428586.1	3	Reactome: R-HSA-193648;Reactome: R-HSA-194840;Reactome: R-HSA-416482	"NRAGE signals death through JNK";"Rho GTPase cycle";"G alpha (12/13) signalling events"
XP_046434885.1	12	MetaCyc: PWY-6672;MetaCyc: PWY-7857;KEGG: 00680+6.2.1.1;MetaCyc: PWY-5133;KEGG: 00620+6.2.1.1;MetaCyc: PWY-5132;KEGG: 00640+6.2.1.1;MetaCyc: PWY-7118;KEGG: 00720+6.2.1.1;KEGG: 00630+6.2.1.1;MetaCyc: PWY-5108;KEGG: 00010+6.2.1.1	"Cis-genanyl-coa degradation";"Adlupulone and adhumulone biosynthesis";"Methane metabolism";"Colupulone and cohumulone biosynthesis";"Pyruvate metabolism";"Lupulone and humulone biosynthesis";"Propanoate metabolism";"Chitin degradation to ethanol";"Carbon fixation pathways in prokaryotes";"Glyoxylate and dicarboxylate metabolism";"L-isoleucine biosynthesis V";"Glycolysis / Gluconeogenesis"
XP_046431087.1	3	Reactome: R-HSA-112382;Reactome: R-HSA-75955;Reactome: R-HSA-674695	"Formation of RNA Pol II elongation complex";"RNA Polymerase II Transcription Elongation";"RNA Polymerase II Pre-transcription Events"
XP_046413458.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_046415649.1	3	Reactome: R-HSA-71262;KEGG: 00310+1.14.11.8;MetaCyc: PWY-6100	"Carnitine synthesis";"Lysine degradation";"L-carnitine biosynthesis"
XP_046409668.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_046412128.1	2	Reactome: R-HSA-6803205;Reactome: R-HSA-8873719	"TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain";"RAB geranylgeranylation"
XP_046427909.1	6	KEGG: 04070+2.7.1.107;Reactome: R-HSA-114508;KEGG: 00564+2.7.1.107;MetaCyc: PWY-7817;KEGG: 00561+2.7.1.107;MetaCyc: PWY-7039	"Phosphatidylinositol signaling system";"Effects of PIP2 hydrolysis";"Glycerophospholipid metabolism";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Glycerolipid metabolism";"Phosphatidate metabolism, as a signaling molecule"
XP_046427753.1	1	Reactome: R-HSA-1614517	"Sulfide oxidation to sulfate"
XP_046411074.1	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
XP_046427118.1	1	Reactome: R-HSA-8964038	"LDL clearance"
XP_046422076.1	2	Reactome: R-HSA-5223345;Reactome: R-HSA-425393	"Miscellaneous transport and binding events";"Transport of inorganic cations/anions and amino acids/oligopeptides"
XP_046427336.1	2	KEGG: 00520+2.4.1.16;MetaCyc: PWY-6981	"Amino sugar and nucleotide sugar metabolism";"Chitin biosynthesis"
XP_046427121.1	1	Reactome: R-HSA-111465	"Apoptotic cleavage of cellular proteins"
XP_046422086.1	3	Reactome: R-HSA-2029482;Reactome: R-HSA-5663213;Reactome: R-HSA-4420097	"Regulation of actin dynamics for phagocytic cup formation";"RHO GTPases Activate WASPs and WAVEs";"VEGFA-VEGFR2 Pathway"
XP_046422168.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046422537.1	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
XP_046428176.1	2	Reactome: R-HSA-195253;Reactome: R-HSA-5689896	"Degradation of beta-catenin by the destruction complex";"Ovarian tumor domain proteases"
XP_046435312.1	1	Reactome: R-HSA-6799198	"Complex I biogenesis"
XP_046427474.1	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
XP_046433488.1	1	Reactome: R-HSA-5620912	"Anchoring of the basal body to the plasma membrane"
XP_046413878.1	3	Reactome: R-HSA-6784531;MetaCyc: PWY-6689;MetaCyc: PWY-7803	"tRNA processing in the nucleus";"Trna splicing I";"Trna splicing II"
XP_046425756.1	3	KEGG: 04660+2.7.10.2;Reactome: R-HSA-6785807;Reactome: R-HSA-8854691	"T cell receptor signaling pathway";"Interleukin-4 and Interleukin-13 signaling";"Interleukin-20 family signaling"
XP_046418021.1	12	Reactome: R-HSA-2979096;Reactome: R-HSA-9017802;Reactome: R-HSA-193692;Reactome: R-HSA-9013507;Reactome: R-HSA-1251985;Reactome: R-HSA-977225;Reactome: R-HSA-2894862;Reactome: R-HSA-9013700;Reactome: R-HSA-2122948;Reactome: R-HSA-205043;Reactome: R-HSA-3928665;Reactome: R-HSA-2644606	"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Noncanonical activation of NOTCH3";"Regulated proteolysis of p75NTR";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Nuclear signaling by ERBB4";"Amyloid fiber formation";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"NOTCH4 Activation and Transmission of Signal to the Nucleus";"Activated NOTCH1 Transmits Signal to the Nucleus";"NRIF signals cell death from the nucleus";"EPH-ephrin mediated repulsion of cells";"Constitutive Signaling by NOTCH1 PEST Domain Mutants"
XP_046425356.1	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
XP_046425726.1	13	Reactome: R-HSA-166208;Reactome: R-HSA-5218920;Reactome: R-HSA-1632852;Reactome: R-HSA-1257604;Reactome: R-HSA-6804757;Reactome: R-HSA-165159;Reactome: R-HSA-380972;Reactome: R-HSA-5674400;Reactome: R-HSA-389357;Reactome: R-HSA-3371571;Reactome: R-HSA-9639288;Reactome: R-HSA-8943724;Reactome: R-HSA-5628897	"mTORC1-mediated signalling";"VEGFR2 mediated vascular permeability";"Macroautophagy";"PIP3 activates AKT signaling";"Regulation of TP53 Degradation";"mTOR signalling";"Energy dependent regulation of mTOR by LKB1-AMPK";"Constitutive Signaling by AKT1 E17K in Cancer";"CD28 dependent PI3K/Akt signaling";"HSF1-dependent transactivation";"Amino acids regulate mTORC1";"Regulation of PTEN gene transcription";"TP53 Regulates Metabolic Genes"
XP_046419912.1	19	Reactome: R-HSA-3371571;Reactome: R-HSA-6802952;Reactome: R-HSA-9649948;Reactome: R-HSA-442982;Reactome: R-HSA-6802955;Reactome: R-HSA-6802946;Reactome: R-HSA-5673000;Reactome: R-HSA-9620244;Reactome: R-HSA-5673001;Reactome: R-HSA-9609736;Reactome: R-HSA-5578775;Reactome: R-HSA-399719;Reactome: R-HSA-936837;Reactome: R-HSA-877300;Reactome: R-HSA-5576892;Reactome: R-HSA-9617324;Reactome: R-HSA-438066;Reactome: R-HSA-111932;Reactome: R-HSA-9022692	"HSF1-dependent transactivation";"Signaling by BRAF and RAF fusions";"Signaling downstream of RAS mutants";"Ras activation upon Ca2+ influx through NMDA receptor";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"Signaling by moderate kinase activity BRAF mutants";"RAF activation";"Long-term potentiation";"RAF/MAP kinase cascade";"Assembly and cell surface presentation of NMDA receptors";"Ion homeostasis";"Trafficking of AMPA receptors";"Ion transport by P-type ATPases";"Interferon gamma signaling";"Phase 0 - rapid depolarisation";"Negative regulation of NMDA receptor-mediated neuronal transmission";"Unblocking of NMDA receptors, glutamate binding and activation";"CaMK IV-mediated phosphorylation of CREB";"Regulation of MECP2 expression and activity"
XP_046423591.1	6	MetaCyc: PWY-6362;Reactome: R-HSA-1855183;MetaCyc: PWY-6364;KEGG: 04070+3.1.3.56;MetaCyc: PWY-6363;KEGG: 00562+3.1.3.56	"1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)";"Synthesis of IP2, IP, and Ins in the cytosol";"D-myo-inositol (1,3,4)-trisphosphate biosynthesis";"Phosphatidylinositol signaling system";"D-myo-inositol (1,4,5)-trisphosphate degradation";"Inositol phosphate metabolism"
XP_046435076.1	7	KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1	"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Relaxin signaling pathway";"Thermogenesis";"Human cytomegalovirus infection"
XP_046420185.1	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
XP_046426939.1	6	MetaCyc: PWY-6606;MetaCyc: PWY-6608;KEGG: 00230+3.5.4.3;Reactome: R-HSA-74259;MetaCyc: PWY-7442;MetaCyc: PWY-5497	"Guanosine nucleotides degradation II";"Guanosine nucleotides degradation III";"Purine metabolism";"Purine catabolism";"Drosopterin and aurodrosopterin biosynthesis";"Purine nucleobases degradation II (anaerobic)"
XP_046414767.1	13	Reactome: R-HSA-74259;KEGG: 00740+3.6.1.9;KEGG: 00230+3.6.1.66;KEGG: 00760+3.6.1.9;KEGG: 00500+3.6.1.9;KEGG: 00230+3.6.1.9;MetaCyc: PWY-6545;KEGG: 00240+3.6.1.9;KEGG: 00770+3.6.1.9;MetaCyc: PWY-7821;MetaCyc: PWY-7206;MetaCyc: PWY-7184;MetaCyc: PWY-7187	"Purine catabolism";"Riboflavin metabolism";"Purine metabolism";"Nicotinate and nicotinamide metabolism";"Starch and sucrose metabolism";"Purine metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Pyrimidine metabolism";"Pantothenate and CoA biosynthesis";"Tunicamycin biosynthesis";"Pyrimidine deoxyribonucleotides dephosphorylation";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Pyrimidine deoxyribonucleotides de novo biosynthesis II"
XP_046428219.1	1	Reactome: R-HSA-83936	"Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"
XP_046419419.1	1	Reactome: R-HSA-432722	"Golgi Associated Vesicle Biogenesis"
XP_046411629.1	3	Reactome: R-HSA-1989781;Reactome: R-HSA-381340;Reactome: R-HSA-212436	"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation";"Generic Transcription Pathway"
XP_046421703.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_046429311.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_046433668.1	2	Reactome: R-HSA-1169408;Reactome: R-HSA-168276	"ISG15 antiviral mechanism";"NS1 Mediated Effects on Host Pathways"
XP_046416456.1	31	MetaCyc: PWY-5366;MetaCyc: PWY-6282;Reactome: R-HSA-75105;KEGG: 00061+1.1.1.100+2.3.1.85+4.2.1.59+2.3.1.39+2.3.1.41+3.1.2.14;MetaCyc: PWY-5973;MetaCyc: PWY-8047;MetaCyc: PWY-5989;MetaCyc: PWY-5147;MetaCyc: PWY-7746;MetaCyc: PWY-7723;MetaCyc: PWY-7858;Reactome: R-HSA-9029558;MetaCyc: PWY-6113;MetaCyc: PWY-5994;MetaCyc: PWY-5971;Reactome: R-HSA-163765;MetaCyc: PWY-6519;MetaCyc: PWY-7663;MetaCyc: PWY-5966-1;MetaCyc: PWY-7388;MetaCyc: PWY-4381;MetaCyc: PWY-6799;Reactome: R-HSA-2426168;Reactome: R-HSA-199220;MetaCyc: PWY-8012;MetaCyc: PWY-8049;MetaCyc: PWYG-321;MetaCyc: PWY-5367;KEGG: 00780+1.1.1.100+4.2.1.59+2.3.1.41;MetaCyc: PWY-7664;MetaCyc: PWY-5142	"Palmitoleate biosynthesis II (plants and bacteria)";"Palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate)";"Fatty acyl-CoA biosynthesis";"Fatty acid biosynthesis";"Cis-vaccenate biosynthesis";"Bryostatin biosynthesis";"Stearate biosynthesis II (bacteria and plants)";"Oleate biosynthesis I (plants)";"Mycobacterial sulfolipid biosynthesis";"Bacterial bioluminescence";"(5Z)-dodecenoate biosynthesis II";"NR1H2 & NR1H3 regulate gene expression linked to lipogenesis";"Superpathway of mycolate biosynthesis";"Palmitate biosynthesis (animals and fungi, cytoplasm)";"Palmitate biosynthesis II (bacteria and plant cytoplasm)";"ChREBP activates metabolic gene expression";"8-amino-7-oxononanoate biosynthesis I";"Gondoate biosynthesis (anaerobic)";"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)";"Octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast)";"Fatty acid biosynthesis initiation (bacteria and plants)";"Fatty acid biosynthesis initiation (plant mitochondria)";"Activation of gene expression by SREBF (SREBP)";"Vitamin B5 (pantothenate) metabolism";"Mupirocin biosynthesis";"Pederin biosynthesis";"";"Petroselinate biosynthesis";"Biotin metabolism";"Oleate biosynthesis IV (anaerobic)";"Acyl-[acyl-carrier protein] thioesterase pathway"
XP_046412982.1	1	Reactome: R-HSA-112126	"ALKBH3 mediated reversal of alkylation damage"
XP_046424825.1	1	KEGG: 04150+2.7.11.24	"mTOR signaling pathway"
XP_046409631.1	10	Reactome: R-HSA-111463;Reactome: R-HSA-9627069;Reactome: R-HSA-111459;Reactome: R-HSA-111457;Reactome: R-HSA-3299685;Reactome: R-HSA-2151201;Reactome: R-HSA-111458;Reactome: R-HSA-5628897;Reactome: R-HSA-611105;Reactome: R-HSA-111464	"SMAC (DIABLO) binds to IAPs";"Regulation of the apoptosome activity";"Activation of caspases through apoptosome-mediated cleavage";"Release of apoptotic factors from the mitochondria";"Detoxification of Reactive Oxygen Species";"Transcriptional activation of mitochondrial biogenesis";"Formation of apoptosome";"TP53 Regulates Metabolic Genes";"Respiratory electron transport";"SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes"
XP_046428254.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
XP_046429268.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046422743.1	22	Reactome: R-HSA-5467348;Reactome: R-HSA-5663220;Reactome: R-HSA-5467337;Reactome: R-HSA-196299;Reactome: R-HSA-5358749;Reactome: R-HSA-4641262;Reactome: R-HSA-5339716;Reactome: R-HSA-432142;Reactome: R-HSA-5675221;Reactome: R-HSA-68877;Reactome: R-HSA-5673000;Reactome: R-HSA-2500257;Reactome: R-HSA-389513;Reactome: R-HSA-5358747;Reactome: R-HSA-5467340;Reactome: R-HSA-6811558;Reactome: R-HSA-195253;Reactome: R-HSA-2467813;Reactome: R-HSA-5358752;Reactome: R-HSA-9648025;Reactome: R-HSA-5358751;Reactome: R-HSA-141444	"Truncations of AMER1 destabilize the destruction complex";"RHO GTPases Activate Formins";"APC truncation mutants have impaired AXIN binding";"Beta-catenin phosphorylation cascade";"S37 mutants of beta-catenin aren't phosphorylated";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"Misspliced GSK3beta mutants stabilize beta-catenin";"Platelet sensitization by LDL";"Negative regulation of MAPK pathway";"Mitotic Prometaphase";"RAF activation";"Resolution of Sister Chromatid Cohesion";"CTLA4 inhibitory signaling";"S33 mutants of beta-catenin aren't phosphorylated";"AXIN missense mutants destabilize the destruction complex";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"Degradation of beta-catenin by the destruction complex";"Separation of Sister Chromatids";"T41 mutants of beta-catenin aren't phosphorylated";"EML4 and NUDC in mitotic spindle formation";"S45 mutants of beta-catenin aren't phosphorylated";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"
XP_046428454.1	18	Reactome: R-HSA-1482925;MetaCyc: PWY-6803;MetaCyc: PWY-7783;MetaCyc: PWY-7409;MetaCyc: PWY-7416;Reactome: R-HSA-1482839;MetaCyc: PWY-8053;KEGG: 00591+3.1.1.4;KEGG: 00564+3.1.1.4;Reactome: R-HSA-1482922;MetaCyc: PWY-8051;Reactome: R-HSA-1482788;KEGG: 00565+3.1.1.4;KEGG: 00590+3.1.1.4;Reactome: R-HSA-1483166;KEGG: 00592+3.1.1.4;MetaCyc: PWY-7417;Reactome: R-HSA-1482801	"Acyl chain remodelling of PG";"Phosphatidylcholine acyl editing";"Plasmalogen degradation";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Acyl chain remodelling of PE";"Anandamide biosynthesis II";"Linoleic acid metabolism";"Glycerophospholipid metabolism";"Acyl chain remodelling of PI";"Anandamide biosynthesis I";"Acyl chain remodelling of PC";"Ether lipid metabolism";"Arachidonic acid metabolism";"Synthesis of PA";"alpha-Linolenic acid metabolism";"Phospholipid remodeling (phosphatidate, yeast)";"Acyl chain remodelling of PS"
XP_046422172.1	1	Reactome: R-HSA-5576886	"Phase 4 - resting membrane potential"
XP_046427184.1	11	KEGG: 05163+2.7.11.1;Reactome: R-HSA-171007;Reactome: R-HSA-4420097;Reactome: R-HSA-450302;KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;Reactome: R-HSA-2559580	"Human cytomegalovirus infection";"p38MAPK events";"VEGFA-VEGFR2 Pathway";"activated TAK1 mediates p38 MAPK activation";"Relaxin signaling pathway";"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Thermogenesis";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Oxidative Stress Induced Senescence"
XP_046420077.1	7	KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1	"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Relaxin signaling pathway";"Thermogenesis";"Human cytomegalovirus infection";"mTOR signaling pathway";"PI3K-Akt signaling pathway"
XP_046425284.1	4	Reactome: R-HSA-73621;MetaCyc: PWY-6963;KEGG: 00250+1.4.1.14;KEGG: 00910+1.4.1.14	"Pyrimidine catabolism";"Ammonia assimilation cycle I";"Alanine, aspartate and glutamate metabolism";"Nitrogen metabolism"
XP_046434247.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046421869.1	7	KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1	"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Relaxin signaling pathway";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Human cytomegalovirus infection";"Thermogenesis"
XP_046427446.1	5	Reactome: R-HSA-9639288;Reactome: R-HSA-917977;Reactome: R-HSA-77387;Reactome: R-HSA-1222556;Reactome: R-HSA-983712	"Amino acids regulate mTORC1";"Transferrin endocytosis and recycling";"Insulin receptor recycling";"ROS and RNS production in phagocytes";"Ion channel transport"
XP_046436671.1	12	Reactome: R-HSA-2500257;Reactome: R-HSA-5663220;Reactome: R-HSA-6807878;Reactome: R-HSA-3371497;Reactome: R-HSA-2132295;Reactome: R-HSA-9646399;Reactome: R-HSA-2467813;Reactome: R-HSA-6811436;Reactome: R-HSA-9609690;Reactome: R-HSA-68877;Reactome: R-HSA-141444;Reactome: R-HSA-9648025	"Resolution of Sister Chromatid Cohesion";"RHO GTPases Activate Formins";"COPI-mediated anterograde transport";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"MHC class II antigen presentation";"Aggrephagy";"Separation of Sister Chromatids";"COPI-independent Golgi-to-ER retrograde traffic";"HCMV Early Events";"Mitotic Prometaphase";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"EML4 and NUDC in mitotic spindle formation"
XP_046419510.1	3	Reactome: R-HSA-3000157;Reactome: R-HSA-3000171;Reactome: R-HSA-8874081	"Laminin interactions";"Non-integrin membrane-ECM interactions";"MET activates PTK2 signaling"
XP_046416589.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046419807.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046431126.1	2	Reactome: R-HSA-390522;Reactome: R-HSA-445355	"Striated Muscle Contraction";"Smooth Muscle Contraction"
XP_046415914.1	19	MetaCyc: PWY-5913;KEGG: 00630+1.1.1.37;MetaCyc: PWY-7383;KEGG: 00270+1.1.1.37;MetaCyc: PWY-8086;MetaCyc: PWY-7115;MetaCyc: PWY-5392;MetaCyc: PWY-561;MetaCyc: PWY-1622;Reactome: R-HSA-70263;MetaCyc: PWY-5690;Reactome: R-HSA-71403;KEGG: 00020+1.1.1.37;MetaCyc: PWY-6728;MetaCyc: PWY-6969;KEGG: 00710+1.1.1.37;KEGG: 00720+1.1.1.37;KEGG: 00620+1.1.1.37;KEGG: 00680+1.1.1.37	"Partial TCA cycle (obligate autotrophs)";"Glyoxylate and dicarboxylate metabolism";"Anaerobic energy metabolism (invertebrates, cytosol)";"Cysteine and methionine metabolism";"(S)-lactate fermentation to propanoate, acetate and hydrogen";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"Reductive TCA cycle II";"Superpathway of glyoxylate cycle and fatty acid degradation";"Formaldehyde assimilation I (serine pathway)";"Gluconeogenesis";"TCA cycle II (plants and fungi)";"Citric acid cycle (TCA cycle)";"Citrate cycle (TCA cycle)";"Methylaspartate cycle";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Carbon fixation in photosynthetic organisms";"Carbon fixation pathways in prokaryotes";"Pyruvate metabolism";"Methane metabolism"
XP_046435584.1	6	Reactome: R-HSA-70370;MetaCyc: PWY-6317;MetaCyc: PWY-6527;KEGG: 00520+2.7.7.12;Reactome: R-HSA-5609978;KEGG: 00052+2.7.7.12	"Galactose catabolism";"D-galactose degradation I (Leloir pathway)";"Stachyose degradation";"Amino sugar and nucleotide sugar metabolism";"Defective GALT can cause Galactosemia";"Galactose metabolism"
XP_046423104.1	1	Reactome: R-HSA-3299685	"Detoxification of Reactive Oxygen Species"
XP_046409973.1	2	Reactome: R-HSA-3214858;Reactome: R-HSA-8939243	"RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"
XP_046427320.1	2	Reactome: R-HSA-8856828;Reactome: R-HSA-8856825	"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis"
XP_046419811.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046415955.1	6	MetaCyc: PWY-7234;MetaCyc: PWY-6123;KEGG: 00670+2.1.2.3;MetaCyc: PWY-6124;Reactome: R-HSA-73817;KEGG: 00230+3.5.4.10+2.1.2.3	"Inosine-5'-phosphate biosynthesis III";"Inosine-5'-phosphate biosynthesis I";"One carbon pool by folate";"Inosine-5'-phosphate biosynthesis II";"Purine ribonucleoside monophosphate biosynthesis";"Purine metabolism"
XP_046414331.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046432260.1	3	Reactome: R-HSA-1989781;Reactome: R-HSA-381340;Reactome: R-HSA-212436	"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation";"Generic Transcription Pathway"
XP_046418339.1	3	Reactome: R-HSA-194840;Reactome: R-HSA-416482;Reactome: R-HSA-193648	"Rho GTPase cycle";"G alpha (12/13) signalling events";"NRAGE signals death through JNK"
XP_046425846.1	1	Reactome: R-HSA-71064	"Lysine catabolism"
XP_046424378.1	2	Reactome: R-HSA-6814122;Reactome: R-HSA-418594	"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"G alpha (i) signalling events"
XP_046413518.1	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
XP_046413189.1	8	KEGG: 04714+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05163+2.7.11.1;Reactome: R-HSA-975957;KEGG: 04926+2.7.11.1	"Thermogenesis";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Human cytomegalovirus infection";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Relaxin signaling pathway"
XP_046419507.1	3	Reactome: R-HSA-3000157;Reactome: R-HSA-3000171;Reactome: R-HSA-8874081	"Laminin interactions";"Non-integrin membrane-ECM interactions";"MET activates PTK2 signaling"
XP_046426751.1	1	Reactome: R-HSA-110320	"Translesion Synthesis by POLH"
XP_046423159.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046409538.1	2	Reactome: R-HSA-72163;Reactome: R-HSA-430039	"mRNA Splicing - Major Pathway";"mRNA decay by 5' to 3' exoribonuclease"
XP_046431901.1	3	KEGG: 00130+4.1.1.90;Reactome: R-HSA-159740;MetaCyc: PWY-7999	"Ubiquinone and other terpenoid-quinone biosynthesis";"Gamma-carboxylation of protein precursors";"Vitamin K-epoxide cycle"
XP_046428663.1	4	KEGG: 00564+3.1.1.32;MetaCyc: PWY-6803;KEGG: 00592+3.1.1.32;MetaCyc: PWY-8051	"Glycerophospholipid metabolism";"Phosphatidylcholine acyl editing";"alpha-Linolenic acid metabolism";"Anandamide biosynthesis I"
XP_046431668.1	13	KEGG: 00520+3.2.1.52;Reactome: R-HSA-2024101;MetaCyc: PWY-7822;KEGG: 00513+3.2.1.52;MetaCyc: PWY-6902;KEGG: 00531+3.2.1.52;Reactome: R-HSA-2160916;KEGG: 00604+3.2.1.52;KEGG: 00603+3.2.1.52;KEGG: 00511+3.2.1.52;Reactome: R-HSA-1660662;Reactome: R-HSA-2022857;MetaCyc: PWY-7883	"Amino sugar and nucleotide sugar metabolism";"CS/DS degradation";"Chitin degradation III (Serratia)";"Various types of N-glycan biosynthesis";"Chitin degradation II (Vibrio)";"Glycosaminoglycan degradation";"Hyaluronan uptake and degradation";"Glycosphingolipid biosynthesis - ganglio series";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Other glycan degradation";"Glycosphingolipid metabolism";"Keratan sulfate degradation";"Anhydromuropeptides recycling II"
XP_046412694.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046436305.1	4	MetaCyc: PWY-3722;MetaCyc: PWY-7494;Reactome: R-HSA-6798163;KEGG: 00260+1.2.1.8+1.1.99.1	"Glycine betaine biosynthesis II (Gram-positive bacteria)";"Choline degradation IV";"Choline catabolism";"Glycine, serine and threonine metabolism"
XP_046426461.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_046416844.1	6	MetaCyc: PWY-7656;KEGG: 00073+1.2.1.84;MetaCyc: PWY-6733;Reactome: R-HSA-9640463;MetaCyc: PWY-5884;MetaCyc: PWY-7782	"Spodoptera littoralis pheromone biosynthesis";"Cutin, suberine and wax biosynthesis";"Sporopollenin precursors biosynthesis";"Wax biosynthesis";"Wax esters biosynthesis I";"Plasmalogen biosynthesis"
XP_046421650.1	2	Reactome: R-HSA-373752;Reactome: R-HSA-525793	"Netrin-1 signaling";"Myogenesis"
XP_046435196.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_046425474.1	3	Reactome: R-HSA-422085;Reactome: R-HSA-1483191;Reactome: R-HSA-112311	"Synthesis, secretion, and deacylation of Ghrelin";"Synthesis of PC";"Neurotransmitter clearance"
XP_046435905.1	2	Reactome: R-HSA-6807878;Reactome: R-HSA-445095	"COPI-mediated anterograde transport";"Interaction between L1 and Ankyrins"
XP_046410241.1	1	Reactome: R-HSA-975957	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
XP_046421651.1	2	Reactome: R-HSA-525793;Reactome: R-HSA-373752	"Myogenesis";"Netrin-1 signaling"
XP_046415232.1	4	Reactome: R-HSA-2468052;Reactome: R-HSA-2467813;Reactome: R-HSA-2500257;Reactome: R-HSA-2470946	"Establishment of Sister Chromatid Cohesion";"Separation of Sister Chromatids";"Resolution of Sister Chromatid Cohesion";"Cohesin Loading onto Chromatin"
XP_046423844.1	1	Reactome: R-HSA-3214858	"RMTs methylate histone arginines"
XP_046412896.1	1	Reactome: R-HSA-611105	"Respiratory electron transport"
XP_046421673.1	2	Reactome: R-HSA-72165;Reactome: R-HSA-72163	"mRNA Splicing - Minor Pathway";"mRNA Splicing - Major Pathway"
XP_046430611.1	39	Reactome: R-HSA-190371;Reactome: R-HSA-8853338;Reactome: R-HSA-5655253;Reactome: R-HSA-109704;Reactome: R-HSA-1839122;Reactome: R-HSA-2219530;Reactome: R-HSA-2033519;Reactome: R-HSA-5654704;Reactome: R-HSA-5654720;Reactome: R-HSA-5654719;Reactome: R-HSA-5654699;Reactome: R-HSA-5654700;Reactome: R-HSA-190373;Reactome: R-HSA-2033514;Reactome: R-HSA-5654221;Reactome: R-HSA-5654693;Reactome: R-HSA-1839130;Reactome: R-HSA-5658623;Reactome: R-HSA-5654712;Reactome: R-HSA-5654732;Reactome: R-HSA-5655302;Reactome: R-HSA-190372;Reactome: R-HSA-1257604;Reactome: R-HSA-5654689;Reactome: R-HSA-5654733;Reactome: R-HSA-5654710;Reactome: R-HSA-5654695;Reactome: R-HSA-6811558;Reactome: R-HSA-5654687;Reactome: R-HSA-5654727;Reactome: R-HSA-5654706;Reactome: R-HSA-5654688;Reactome: R-HSA-190375;Reactome: R-HSA-5654227;Reactome: R-HSA-5654228;Reactome: R-HSA-5654726;Reactome: R-HSA-190322;Reactome: R-HSA-5673001;Reactome: R-HSA-5654219	"FGFR3b ligand binding and activation";"Signaling by FGFR3 point mutants in cancer";"Signaling by FGFR2 in disease";"PI3K Cascade";"Signaling by activated point mutants of FGFR1";"Constitutive Signaling by Aberrant PI3K in Cancer";"Activated point mutants of FGFR2";"SHC-mediated cascade:FGFR3";"PI-3K cascade:FGFR4";"SHC-mediated cascade:FGFR4";"SHC-mediated cascade:FGFR2";"FRS-mediated FGFR2 signaling";"FGFR1c ligand binding and activation";"FGFR3 mutant receptor activation";"Phospholipase C-mediated cascade, FGFR2";"FRS-mediated FGFR1 signaling";"Signaling by activated point mutants of FGFR3";"FGFRL1 modulation of FGFR1 signaling";"FRS-mediated FGFR4 signaling";"Negative regulation of FGFR3 signaling";"Signaling by FGFR1 in disease";"FGFR3c ligand binding and activation";"PIP3 activates AKT signaling";"PI-3K cascade:FGFR1";"Negative regulation of FGFR4 signaling";"PI-3K cascade:FGFR3";"PI-3K cascade:FGFR2";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"Downstream signaling of activated FGFR1";"Negative regulation of FGFR2 signaling";"FRS-mediated FGFR3 signaling";"SHC-mediated cascade:FGFR1";"FGFR2c ligand binding and activation";"Phospholipase C-mediated cascade, FGFR3";"Phospholipase C-mediated cascade, FGFR4";"Negative regulation of FGFR1 signaling";"FGFR4 ligand binding and activation";"RAF/MAP kinase cascade";"Phospholipase C-mediated cascade: FGFR1"
XP_046413611.1	1	Reactome: R-HSA-6809371	"Formation of the cornified envelope"
XP_046433959.1	1	Reactome: R-HSA-3299685	"Detoxification of Reactive Oxygen Species"
XP_046433264.1	8	Reactome: R-HSA-113501;Reactome: R-HSA-68952;Reactome: R-HSA-69091;Reactome: R-HSA-68962;Reactome: R-HSA-69183;Reactome: R-HSA-174411;Reactome: R-HSA-69166;Reactome: R-HSA-174430	"Inhibition of replication initiation of damaged DNA by RB1/E2F1";"DNA replication initiation";"Polymerase switching";"Activation of the pre-replicative complex";"Processive synthesis on the lagging strand";"Polymerase switching on the C-strand of the telomere";"Removal of the Flap Intermediate";"Telomere C-strand synthesis initiation"
XP_046427370.1	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
XP_046411098.1	2	Reactome: R-HSA-6784531;Reactome: R-HSA-6791226	"tRNA processing in the nucleus";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046412113.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_046410248.1	1	Reactome: R-HSA-975957	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
XP_046418975.1	27	Reactome: R-HSA-4570464;Reactome: R-HSA-9610379;Reactome: R-HSA-9609690;Reactome: R-HSA-159231;Reactome: R-HSA-3108214;Reactome: R-HSA-168325;Reactome: R-HSA-1169408;Reactome: R-HSA-159236;Reactome: R-HSA-3371453;Reactome: R-HSA-180910;Reactome: R-HSA-3232142;Reactome: R-HSA-170822;Reactome: R-HSA-4551638;Reactome: R-HSA-4085377;Reactome: R-HSA-6784531;Reactome: R-HSA-165054;Reactome: R-HSA-168276;Reactome: R-HSA-3301854;Reactome: R-HSA-5619107;Reactome: R-HSA-4615885;Reactome: R-HSA-5578749;Reactome: R-HSA-159230;Reactome: R-HSA-180746;Reactome: R-HSA-191859;Reactome: R-HSA-168271;Reactome: R-HSA-168333;Reactome: R-HSA-159227	"SUMOylation of RNA binding proteins";"HCMV Late Events";"HCMV Early Events";"Transport of Mature mRNA Derived from an Intronless Transcript";"SUMOylation of DNA damage response and repair proteins";"Viral Messenger RNA Synthesis";"ISG15 antiviral mechanism";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Regulation of HSF1-mediated heat shock response";"Vpr-mediated nuclear import of PICs";"SUMOylation of ubiquitinylation proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"SUMOylation of chromatin organization proteins";"SUMOylation of SUMOylation proteins";"tRNA processing in the nucleus";"Rev-mediated nuclear export of HIV RNA";"NS1 Mediated Effects on Host Pathways";"Nuclear Pore Complex (NPC) Disassembly";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"SUMOylation of DNA replication proteins";"Transcriptional regulation by small RNAs";"Transport of the SLBP Dependant Mature mRNA";"Nuclear import of Rev protein";"snRNP Assembly";"Transport of Ribonucleoproteins into the Host Nucleus";"NEP/NS2 Interacts with the Cellular Export Machinery";"Transport of the SLBP independent Mature mRNA"
XP_046418214.1	1	Reactome: R-HSA-611105	"Respiratory electron transport"
XP_046413404.1	2	Reactome: R-HSA-5696394;Reactome: R-HSA-5689603	"DNA Damage Recognition in GG-NER";"UCH proteinases"
XP_046421045.1	5	KEGG: 00020+1.2.4.2;Reactome: R-HSA-389661;MetaCyc: PWY-5084;KEGG: 00310+1.2.4.2;KEGG: 00380+1.2.4.2	"Citrate cycle (TCA cycle)";"Glyoxylate metabolism and glycine degradation";"2-oxoglutarate decarboxylation to succinyl-CoA";"Lysine degradation";"Tryptophan metabolism"
XP_046417488.1	4	KEGG: 00230+2.7.4.3;Reactome: R-HSA-499943;KEGG: 00730+2.7.4.3;MetaCyc: PWY-7219	"Purine metabolism";"Interconversion of nucleotide di- and triphosphates";"Thiamine metabolism";"Adenosine ribonucleotides de novo biosynthesis"
XP_046418837.1	1	Reactome: R-HSA-83936	"Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"
XP_046412689.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046430483.1	4	Reactome: R-HSA-3769402;Reactome: R-HSA-2122947;Reactome: R-HSA-201722;Reactome: R-HSA-4641265	"Deactivation of the beta-catenin transactivating complex";"NOTCH1 Intracellular Domain Regulates Transcription";"Formation of the beta-catenin:TCF transactivating complex";"Repression of WNT target genes"
XP_046415200.1	2	Reactome: R-HSA-383280;Reactome: R-HSA-983231	"Nuclear Receptor transcription pathway";"Factors involved in megakaryocyte development and platelet production"
XP_046410412.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046418412.1	7	KEGG: 00564+2.7.8.11;KEGG: 04070+2.7.8.11;MetaCyc: PWY-6352;MetaCyc: PWY-6351;KEGG: 00562+2.7.8.11;MetaCyc: PWY-7625;Reactome: R-HSA-1483226	"Glycerophospholipid metabolism";"Phosphatidylinositol signaling system";"3-phosphoinositide biosynthesis";"D-myo-inositol (1,4,5)-trisphosphate biosynthesis";"Inositol phosphate metabolism";"Phosphatidylinositol biosynthesis II (eukaryotes)";"Synthesis of PI"
XP_046418259.1	1	Reactome: R-HSA-110357	"Displacement of DNA glycosylase by APEX1"
XP_046435378.1	2	Reactome: R-HSA-8856825;Reactome: R-HSA-8856828	"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis"
XP_046413234.1	1	Reactome: R-HSA-70221	"Glycogen breakdown (glycogenolysis)"
XP_046431846.1	2	Reactome: R-HSA-8939243;Reactome: R-HSA-3214858	"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RMTs methylate histone arginines"
XP_046414974.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046430008.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_046413427.1	11	Reactome: R-HSA-6811558;Reactome: R-HSA-1963642;Reactome: R-HSA-8863795;Reactome: R-HSA-1250196;Reactome: R-HSA-1257604;Reactome: R-HSA-8847993;Reactome: R-HSA-5673001;Reactome: R-HSA-1227986;Reactome: R-HSA-9664565;Reactome: R-HSA-2219530;Reactome: R-HSA-6785631	"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"PI3K events in ERBB2 signaling";"Downregulation of ERBB2 signaling";"SHC1 events in ERBB2 signaling";"PIP3 activates AKT signaling";"ERBB2 Activates PTK6 Signaling";"RAF/MAP kinase cascade";"Signaling by ERBB2";"Signaling by ERBB2 KD Mutants";"Constitutive Signaling by Aberrant PI3K in Cancer";"ERBB2 Regulates Cell Motility"
XP_046420900.1	1	Reactome: R-HSA-6799198	"Complex I biogenesis"
XP_046432315.1	3	Reactome: R-HSA-6807878;Reactome: R-HSA-6811440;Reactome: R-HSA-6811438	"COPI-mediated anterograde transport";"Retrograde transport at the Trans-Golgi-Network";"Intra-Golgi traffic"
XP_046413118.1	3	Reactome: R-HSA-8951664;Reactome: R-HSA-390471;Reactome: R-HSA-983168	"Neddylation";"Association of TriC/CCT with target proteins during biosynthesis";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046416237.1	1	KEGG: 00900+3.4.24.84	"Terpenoid backbone biosynthesis"
XP_046431790.1	10	Reactome: R-HSA-2871837;Reactome: R-HSA-2565942;Reactome: R-HSA-5684264;Reactome: R-HSA-1169091;Reactome: R-HSA-5607764;Reactome: R-HSA-5676590;Reactome: R-HSA-202424;Reactome: R-HSA-983168;Reactome: R-HSA-5607761;Reactome: R-HSA-8951664	"FCERI mediated NF-kB activation";"Regulation of PLK1 Activity at G2/M Transition";"MAP3K8 (TPL2)-dependent MAPK1/3 activation";"Activation of NF-kappaB in B cells";"CLEC7A (Dectin-1) signaling";"NIK-->noncanonical NF-kB signaling";"Downstream TCR signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Dectin-1 mediated noncanonical NF-kB signaling";"Neddylation"
XP_046414892.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_046410784.1	6	Reactome: R-HSA-6791226;Reactome: R-HSA-450385;Reactome: R-HSA-450604;Reactome: R-HSA-450513;Reactome: R-HSA-380994;Reactome: R-HSA-429958	"Major pathway of rRNA processing in the nucleolus and cytosol";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"KSRP (KHSRP) binds and destabilizes mRNA";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"ATF4 activates genes in response to endoplasmic reticulum stress";"mRNA decay by 3' to 5' exoribonuclease"
XP_046420865.1	33	Reactome: R-HSA-5619107;Reactome: R-HSA-168276;Reactome: R-HSA-191859;Reactome: R-HSA-159230;Reactome: R-HSA-4615885;Reactome: R-HSA-168271;Reactome: R-HSA-9610379;Reactome: R-HSA-9648025;Reactome: R-HSA-3108214;Reactome: R-HSA-159231;Reactome: R-HSA-1169408;Reactome: R-HSA-2467813;Reactome: R-HSA-3232142;Reactome: R-HSA-2500257;Reactome: R-HSA-3371453;Reactome: R-HSA-4551638;Reactome: R-HSA-3301854;Reactome: R-HSA-5578749;Reactome: R-HSA-180746;Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-168333;Reactome: R-HSA-159227;Reactome: R-HSA-4570464;Reactome: R-HSA-159236;Reactome: R-HSA-141444;Reactome: R-HSA-168325;Reactome: R-HSA-9609690;Reactome: R-HSA-170822;Reactome: R-HSA-180910;Reactome: R-HSA-6784531;Reactome: R-HSA-165054;Reactome: R-HSA-4085377	"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"NS1 Mediated Effects on Host Pathways";"snRNP Assembly";"Transport of the SLBP Dependant Mature mRNA";"SUMOylation of DNA replication proteins";"Transport of Ribonucleoproteins into the Host Nucleus";"HCMV Late Events";"EML4 and NUDC in mitotic spindle formation";"SUMOylation of DNA damage response and repair proteins";"Transport of Mature mRNA Derived from an Intronless Transcript";"ISG15 antiviral mechanism";"Separation of Sister Chromatids";"SUMOylation of ubiquitinylation proteins";"Resolution of Sister Chromatid Cohesion";"Regulation of HSF1-mediated heat shock response";"SUMOylation of chromatin organization proteins";"Nuclear Pore Complex (NPC) Disassembly";"Transcriptional regulation by small RNAs";"Nuclear import of Rev protein";"Mitotic Prometaphase";"RHO GTPases Activate Formins";"NEP/NS2 Interacts with the Cellular Export Machinery";"Transport of the SLBP independent Mature mRNA";"SUMOylation of RNA binding proteins";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Viral Messenger RNA Synthesis";"HCMV Early Events";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Vpr-mediated nuclear import of PICs";"tRNA processing in the nucleus";"Rev-mediated nuclear export of HIV RNA";"SUMOylation of SUMOylation proteins"
XP_046422002.1	2	Reactome: R-HSA-1296052;Reactome: R-HSA-418457	"Ca2+ activated K+ channels";"cGMP effects"
XP_046414679.1	1	Reactome: R-HSA-5358493	"Synthesis of diphthamide-EEF2"
XP_046435329.1	1	MetaCyc: PWY-7437	"Protein O-[N-acetyl]-glucosylation"
XP_046436721.1	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
XP_046432915.1	1	Reactome: R-HSA-110362	"POLB-Dependent Long Patch Base Excision Repair"
XP_046435291.1	3	KEGG: 00730+3.1.3.2;KEGG: 00740+3.1.3.2;MetaCyc: PWY-6348	"Thiamine metabolism";"Riboflavin metabolism";"Phosphate acquisition"
XP_046433718.1	2	Reactome: R-HSA-8949664;Reactome: R-HSA-8949215	"Processing of SMDT1";"Mitochondrial calcium ion transport"
XP_046424478.1	6	KEGG: 00073+1.2.1.84;MetaCyc: PWY-7656;Reactome: R-HSA-9640463;MetaCyc: PWY-6733;MetaCyc: PWY-7782;MetaCyc: PWY-5884	"Cutin, suberine and wax biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Wax biosynthesis";"Sporopollenin precursors biosynthesis";"Plasmalogen biosynthesis";"Wax esters biosynthesis I"
XP_046420590.1	3	Reactome: R-HSA-375276;Reactome: R-HSA-416476;Reactome: R-HSA-418594	"Peptide ligand-binding receptors";"G alpha (q) signalling events";"G alpha (i) signalling events"
XP_046413666.1	6	MetaCyc: PWY-7656;KEGG: 00073+1.2.1.84;MetaCyc: PWY-6733;Reactome: R-HSA-9640463;MetaCyc: PWY-7782;MetaCyc: PWY-5884	"Spodoptera littoralis pheromone biosynthesis";"Cutin, suberine and wax biosynthesis";"Sporopollenin precursors biosynthesis";"Wax biosynthesis";"Plasmalogen biosynthesis";"Wax esters biosynthesis I"
XP_046429140.1	16	Reactome: R-HSA-388841;Reactome: R-HSA-1257604;Reactome: R-HSA-512988;Reactome: R-HSA-2219530;Reactome: R-HSA-1266695;Reactome: R-HSA-9009391;Reactome: R-HSA-912631;Reactome: R-HSA-194840;Reactome: R-HSA-1433557;Reactome: R-HSA-912526;Reactome: R-HSA-114604;Reactome: R-HSA-1660499;Reactome: R-HSA-6811558;Reactome: R-HSA-8853659;Reactome: R-HSA-416476;Reactome: R-HSA-389357	"Costimulation by the CD28 family";"PIP3 activates AKT signaling";"Interleukin-3, Interleukin-5 and GM-CSF signaling";"Constitutive Signaling by Aberrant PI3K in Cancer";"Interleukin-7 signaling";"Extra-nuclear estrogen signaling";"Regulation of signaling by CBL";"Rho GTPase cycle";"Signaling by SCF-KIT";"Interleukin receptor SHC signaling";"GPVI-mediated activation cascade";"Synthesis of PIPs at the plasma membrane";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"RET signaling";"G alpha (q) signalling events";"CD28 dependent PI3K/Akt signaling"
XP_046411486.1	2	Reactome: R-HSA-6807004;Reactome: R-HSA-877312	"Negative regulation of MET activity";"Regulation of IFNG signaling"
XP_046434099.1	2	Reactome: R-HSA-426486;Reactome: R-HSA-203927	"Small interfering RNA (siRNA) biogenesis";"MicroRNA (miRNA) biogenesis"
XP_046422133.1	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276	"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination"
XP_046414960.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_046417539.1	2	Reactome: R-HSA-6798695;Reactome: R-HSA-936837	"Neutrophil degranulation";"Ion transport by P-type ATPases"
XP_046413890.1	6	Reactome: R-HSA-68867;Reactome: R-HSA-176974;Reactome: R-HSA-176187;Reactome: R-HSA-69052;Reactome: R-HSA-68962;Reactome: R-HSA-68949	"Assembly of the pre-replicative complex";"Unwinding of DNA";"Activation of ATR in response to replication stress";"Switching of origins to a post-replicative state";"Activation of the pre-replicative complex";"Orc1 removal from chromatin"
XP_046429494.1	5	KEGG: 05235+3.1.3.16;Reactome: R-HSA-176407;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16;Reactome: R-HSA-5687128	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation";"MAPK6/MAPK4 signaling"
XP_046433028.1	10	Reactome: R-HSA-210744;Reactome: R-HSA-1912408;Reactome: R-HSA-8941856;Reactome: R-HSA-9013695;Reactome: R-HSA-2197563;Reactome: R-HSA-2894862;Reactome: R-HSA-350054;Reactome: R-HSA-9013508;Reactome: R-HSA-2644606;Reactome: R-HSA-2122947	"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"Pre-NOTCH Transcription and Translation";"RUNX3 regulates NOTCH signaling";"NOTCH4 Intracellular Domain Regulates Transcription";"NOTCH2 intracellular domain regulates transcription";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Notch-HLH transcription pathway";"NOTCH3 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH1 Intracellular Domain Regulates Transcription"
XP_046411244.1	1	Reactome: R-HSA-6811440	"Retrograde transport at the Trans-Golgi-Network"
XP_046428777.1	7	KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1	"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Human cytomegalovirus infection";"Thermogenesis";"Relaxin signaling pathway";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection"
XP_046410723.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046416271.1	31	MetaCyc: PWY-5994;MetaCyc: PWY-6113;MetaCyc: PWY-7663;MetaCyc: PWY-6519;MetaCyc: PWY-5971;Reactome: R-HSA-163765;MetaCyc: PWY-5366;KEGG: 00061+1.1.1.100+2.3.1.85+4.2.1.59+2.3.1.39+2.3.1.41+3.1.2.14;MetaCyc: PWY-8047;MetaCyc: PWY-5973;Reactome: R-HSA-75105;MetaCyc: PWY-6282;MetaCyc: PWY-7858;Reactome: R-HSA-9029558;MetaCyc: PWY-5147;MetaCyc: PWY-7723;MetaCyc: PWY-5989;MetaCyc: PWY-7746;Reactome: R-HSA-2426168;MetaCyc: PWY-8012;MetaCyc: PWY-8049;MetaCyc: PWYG-321;Reactome: R-HSA-199220;KEGG: 00780+1.1.1.100+4.2.1.59+2.3.1.41;MetaCyc: PWY-5367;MetaCyc: PWY-5142;MetaCyc: PWY-7664;MetaCyc: PWY-5966-1;MetaCyc: PWY-7388;MetaCyc: PWY-4381;MetaCyc: PWY-6799	"Palmitate biosynthesis (animals and fungi, cytoplasm)";"Superpathway of mycolate biosynthesis";"Gondoate biosynthesis (anaerobic)";"8-amino-7-oxononanoate biosynthesis I";"Palmitate biosynthesis II (bacteria and plant cytoplasm)";"ChREBP activates metabolic gene expression";"Palmitoleate biosynthesis II (plants and bacteria)";"Fatty acid biosynthesis";"Bryostatin biosynthesis";"Cis-vaccenate biosynthesis";"Fatty acyl-CoA biosynthesis";"Palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate)";"(5Z)-dodecenoate biosynthesis II";"NR1H2 & NR1H3 regulate gene expression linked to lipogenesis";"Oleate biosynthesis I (plants)";"Bacterial bioluminescence";"Stearate biosynthesis II (bacteria and plants)";"Mycobacterial sulfolipid biosynthesis";"Activation of gene expression by SREBF (SREBP)";"Mupirocin biosynthesis";"Pederin biosynthesis";"";"Vitamin B5 (pantothenate) metabolism";"Biotin metabolism";"Petroselinate biosynthesis";"Acyl-[acyl-carrier protein] thioesterase pathway";"Oleate biosynthesis IV (anaerobic)";"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)";"Octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast)";"Fatty acid biosynthesis initiation (bacteria and plants)";"Fatty acid biosynthesis initiation (plant mitochondria)"
XP_046412643.1	4	Reactome: R-HSA-350054;Reactome: R-HSA-2894862;Reactome: R-HSA-2122947;Reactome: R-HSA-2644606	"Notch-HLH transcription pathway";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"NOTCH1 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 PEST Domain Mutants"
XP_046413167.1	1	KEGG: 00760+2.3.1.286	"Nicotinate and nicotinamide metabolism"
XP_046431717.1	5	Reactome: R-HSA-168638;Reactome: R-HSA-4420097;Reactome: R-HSA-171007;KEGG: 04150+2.7.11.24;Reactome: R-HSA-376172	"NOD1/2 Signaling Pathway";"VEGFA-VEGFR2 Pathway";"p38MAPK events";"mTOR signaling pathway";"DSCAM interactions"
XP_046413824.1	3	KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway"
XP_046417191.1	4	KEGG: 00564+3.1.1.32;KEGG: 00592+3.1.1.32;MetaCyc: PWY-8051;MetaCyc: PWY-6803	"Glycerophospholipid metabolism";"alpha-Linolenic acid metabolism";"Anandamide biosynthesis I";"Phosphatidylcholine acyl editing"
XP_046428190.1	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
XP_046425531.1	13	MetaCyc: PWY-7226;MetaCyc: PWY-7198;MetaCyc: PWY-7227;KEGG: 00230+1.17.4.1;KEGG: 00480+1.17.4.1;KEGG: 00983+1.17.4.1;MetaCyc: PWY-7220;MetaCyc: PWY-6545;KEGG: 00240+1.17.4.1;MetaCyc: PWY-7222;MetaCyc: PWY-7210;MetaCyc: PWY-7184;Reactome: R-HSA-499943	"Guanosine deoxyribonucleotides de novo biosynthesis I";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Adenosine deoxyribonucleotides de novo biosynthesis";"Purine metabolism";"Glutathione metabolism";"Drug metabolism - other enzymes";"Adenosine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Pyrimidine metabolism";"Guanosine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Interconversion of nucleotide di- and triphosphates"
XP_046415147.1	24	Reactome: R-HSA-3371497;Reactome: R-HSA-5663220;Reactome: R-HSA-437239;Reactome: R-HSA-68877;Reactome: R-HSA-190840;Reactome: R-HSA-8852276;Reactome: R-HSA-9646399;Reactome: R-HSA-190861;Reactome: R-HSA-6811436;Reactome: R-HSA-8955332;Reactome: R-HSA-9609736;Reactome: R-HSA-2132295;Reactome: R-HSA-5617833;Reactome: R-HSA-6807878;Reactome: R-HSA-5626467;Reactome: R-HSA-1445148;Reactome: R-HSA-2500257;Reactome: R-HSA-983189;Reactome: R-HSA-9619483;Reactome: R-HSA-9609690;Reactome: R-HSA-2467813;Reactome: R-HSA-9648025;Reactome: R-HSA-380320;Reactome: R-HSA-6811434	"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"RHO GTPases Activate Formins";"Recycling pathway of L1";"Mitotic Prometaphase";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Aggrephagy";"Gap junction assembly";"COPI-independent Golgi-to-ER retrograde traffic";"Carboxyterminal post-translational modifications of tubulin";"Assembly and cell surface presentation of NMDA receptors";"MHC class II antigen presentation";"Cilium Assembly";"COPI-mediated anterograde transport";"RHO GTPases activate IQGAPs";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Resolution of Sister Chromatid Cohesion";"Kinesins";"Activation of AMPK downstream of NMDARs";"HCMV Early Events";"Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation";"Recruitment of NuMA to mitotic centrosomes";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_046429051.1	5	Reactome: R-HSA-5693571;Reactome: R-HSA-1834949;Reactome: R-HSA-6798695;Reactome: R-HSA-164843;Reactome: R-HSA-3270619	"Nonhomologous End-Joining (NHEJ)";"Cytosolic sensors of pathogen-associated DNA";"Neutrophil degranulation";"2-LTR circle formation";"IRF3-mediated induction of type I IFN"
XP_046431384.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046421145.1	3	KEGG: 00480+4.3.2.7;MetaCyc: PWY-7942;Reactome: R-HSA-174403	"Glutathione metabolism";"5-oxo-L-proline metabolism";"Glutathione synthesis and recycling"
XP_046427976.1	14	Reactome: R-HSA-9022692;Reactome: R-HSA-203927;Reactome: R-HSA-5687128;Reactome: R-HSA-426496;Reactome: R-HSA-9029569;Reactome: R-HSA-426486;Reactome: R-HSA-8934593;Reactome: R-HSA-9018519;Reactome: R-HSA-4086398;Reactome: R-HSA-8986944;Reactome: R-HSA-8943723;Reactome: R-HSA-1912408;Reactome: R-HSA-8948700;Reactome: R-HSA-5628897	"Regulation of MECP2 expression and activity";"MicroRNA (miRNA) biogenesis";"MAPK6/MAPK4 signaling";"Post-transcriptional silencing by small RNAs";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Small interfering RNA (siRNA) biogenesis";"Regulation of RUNX1 Expression and Activity";"Estrogen-dependent gene expression";"Ca2+ pathway";"Transcriptional Regulation by MECP2";"Regulation of PTEN mRNA translation";"Pre-NOTCH Transcription and Translation";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"TP53 Regulates Metabolic Genes"
XP_046411071.1	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
XP_046419520.1	3	Reactome: R-HSA-3000171;Reactome: R-HSA-8874081;Reactome: R-HSA-3000157	"Non-integrin membrane-ECM interactions";"MET activates PTK2 signaling";"Laminin interactions"
XP_046410531.1	1	Reactome: R-HSA-3214842	"HDMs demethylate histones"
XP_046423831.1	1	KEGG: 00051+4.2.1.68	"Fructose and mannose metabolism"
XP_046415691.1	1	Reactome: R-HSA-71262	"Carnitine synthesis"
XP_046427456.1	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
XP_046421533.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_046428800.1	3	KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16	"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
XP_046422755.1	1	Reactome: R-HSA-156584	"Cytosolic sulfonation of small molecules"
XP_046409886.1	7	MetaCyc: PWY-5466;MetaCyc: PWY-5469;MetaCyc: PWY-5461;MetaCyc: PWY-7214;MetaCyc: PWY-7445;MetaCyc: PWY-6824;KEGG: 00940+1.11.1.7	"Matairesinol biosynthesis";"Sesamin biosynthesis";"Betanidin degradation";"Baicalein degradation (hydrogen peroxide detoxification)";"Luteolin triglucuronide degradation";"Justicidin B biosynthesis";"Phenylpropanoid biosynthesis"
XP_046428539.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046429964.1	1	Reactome: R-HSA-8874211	"CREB3 factors activate genes"
XP_046416114.1	5	Reactome: R-HSA-5693579;Reactome: R-HSA-5693554;Reactome: R-HSA-5693616;Reactome: R-HSA-5685942;Reactome: R-HSA-5693568	"Homologous DNA Pairing and Strand Exchange";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Presynaptic phase of homologous DNA pairing and strand exchange";"HDR through Homologous Recombination (HRR)";"Resolution of D-loop Structures through Holliday Junction Intermediates"
XP_046421379.1	2	Reactome: R-HSA-6783310;MetaCyc: PWY-7511	"Fanconi Anemia Pathway";"Protein ubiquitination"
XP_046433144.1	1	Reactome: R-HSA-1632852	"Macroautophagy"
XP_046425720.1	2	Reactome: R-HSA-8854214;Reactome: R-HSA-977225	"TBC/RABGAPs";"Amyloid fiber formation"
XP_046426465.1	3	MetaCyc: PWY-4261;KEGG: 00561+2.7.1.30;Reactome: R-HSA-75109	"Glycerol degradation I";"Glycerolipid metabolism";"Triglyceride biosynthesis"
XP_046424473.1	6	Reactome: R-HSA-9640463;MetaCyc: PWY-6733;KEGG: 00073+1.2.1.84;MetaCyc: PWY-7656;MetaCyc: PWY-5884;MetaCyc: PWY-7782	"Wax biosynthesis";"Sporopollenin precursors biosynthesis";"Cutin, suberine and wax biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Wax esters biosynthesis I";"Plasmalogen biosynthesis"
XP_046415310.1	2	Reactome: R-HSA-446205;KEGG: 00500+2.4.1.15	"Synthesis of GDP-mannose";"Starch and sucrose metabolism"
XP_046430585.1	1	Reactome: R-HSA-426117	"Cation-coupled Chloride cotransporters"
XP_046427149.1	26	Reactome: R-HSA-6807878;Reactome: R-HSA-5626467;Reactome: R-HSA-1445148;Reactome: R-HSA-389960;Reactome: R-HSA-2500257;Reactome: R-HSA-983189;Reactome: R-HSA-9619483;Reactome: R-HSA-9609690;Reactome: R-HSA-2467813;Reactome: R-HSA-9648025;Reactome: R-HSA-380320;Reactome: R-HSA-6811434;Reactome: R-HSA-3371497;Reactome: R-HSA-5663220;Reactome: R-HSA-437239;Reactome: R-HSA-389977;Reactome: R-HSA-68877;Reactome: R-HSA-190840;Reactome: R-HSA-8852276;Reactome: R-HSA-9646399;Reactome: R-HSA-6811436;Reactome: R-HSA-190861;Reactome: R-HSA-8955332;Reactome: R-HSA-9609736;Reactome: R-HSA-2132295;Reactome: R-HSA-5617833	"COPI-mediated anterograde transport";"RHO GTPases activate IQGAPs";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Formation of tubulin folding intermediates by CCT/TriC";"Resolution of Sister Chromatid Cohesion";"Kinesins";"Activation of AMPK downstream of NMDARs";"HCMV Early Events";"Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation";"Recruitment of NuMA to mitotic centrosomes";"COPI-dependent Golgi-to-ER retrograde traffic";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"RHO GTPases Activate Formins";"Recycling pathway of L1";"Post-chaperonin tubulin folding pathway";"Mitotic Prometaphase";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Aggrephagy";"COPI-independent Golgi-to-ER retrograde traffic";"Gap junction assembly";"Carboxyterminal post-translational modifications of tubulin";"Assembly and cell surface presentation of NMDA receptors";"MHC class II antigen presentation";"Cilium Assembly"
XP_046426433.1	9	Reactome: R-HSA-382556;Reactome: R-HSA-5627083;Reactome: R-HSA-9646399;Reactome: R-HSA-5678895;Reactome: R-HSA-8856828;Reactome: R-HSA-9615710;Reactome: R-HSA-8856825;Reactome: R-HSA-9613829;Reactome: R-HSA-5689880	"ABC-family proteins mediated transport";"RHO GTPases regulate CFTR trafficking";"Aggrephagy";"Defective CFTR causes cystic fibrosis";"Clathrin-mediated endocytosis";"Late endosomal microautophagy";"Cargo recognition for clathrin-mediated endocytosis";"Chaperone Mediated Autophagy";"Ub-specific processing proteases"
XP_046413494.1	11	Reactome: R-HSA-418594;Reactome: R-HSA-432040;Reactome: R-HSA-163615;Reactome: R-HSA-5610787;KEGG: 00230+4.6.1.1;Reactome: R-HSA-170670;Reactome: R-HSA-163359;Reactome: R-HSA-164378;Reactome: R-HSA-418555;Reactome: R-HSA-418597;Reactome: R-HSA-170660	"G alpha (i) signalling events";"Vasopressin regulates renal water homeostasis via Aquaporins";"PKA activation";"Hedgehog 'off' state";"Purine metabolism";"Adenylate cyclase inhibitory pathway";"Glucagon signaling in metabolic regulation";"PKA activation in glucagon signalling";"G alpha (s) signalling events";"G alpha (z) signalling events";"Adenylate cyclase activating pathway"
XP_046433072.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046427927.1	2	Reactome: R-HSA-2151201;Reactome: R-HSA-1989781	"Transcriptional activation of mitochondrial biogenesis";"PPARA activates gene expression"
XP_046420695.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_046427511.1	3	KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16	"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
XP_046431881.1	6	Reactome: R-HSA-174490;Reactome: R-HSA-917729;Reactome: R-HSA-162588;Reactome: R-HSA-9610379;Reactome: R-HSA-8876198;Reactome: R-HSA-9615710	"Membrane binding and targetting of GAG proteins";"Endosomal Sorting Complex Required For Transport (ESCRT)";"Budding and maturation of HIV virion";"HCMV Late Events";"RAB GEFs exchange GTP for GDP on RABs";"Late endosomal microautophagy"
XP_046417768.1	1	Reactome: R-HSA-2022377	"Metabolism of Angiotensinogen to Angiotensins"
XP_046431482.1	3	Reactome: R-HSA-4420097;Reactome: R-HSA-2029482;Reactome: R-HSA-5663213	"VEGFA-VEGFR2 Pathway";"Regulation of actin dynamics for phagocytic cup formation";"RHO GTPases Activate WASPs and WAVEs"
XP_046435081.1	7	KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1	"Thermogenesis";"Human cytomegalovirus infection";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Relaxin signaling pathway";"mTOR signaling pathway";"PI3K-Akt signaling pathway"
XP_046435891.1	3	Reactome: R-HSA-8963901;Reactome: R-HSA-6807878;Reactome: R-HSA-445095	"Chylomicron remodeling";"COPI-mediated anterograde transport";"Interaction between L1 and Ankyrins"
XP_046414492.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046422020.1	2	Reactome: R-HSA-6783984;KEGG: 00260+1.4.4.2	"Glycine degradation";"Glycine, serine and threonine metabolism"
XP_046421352.1	1	Reactome: R-HSA-9037629	"Lewis blood group biosynthesis"
XP_046424081.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_046420181.1	7	Reactome: R-HSA-9018896;Reactome: R-HSA-9023661;Reactome: R-HSA-2142691;Reactome: R-HSA-9018676;Reactome: R-HSA-6798695;Reactome: R-HSA-9020265;Reactome: R-HSA-9018681	"Biosynthesis of E-series 18(S)-resolvins";"Biosynthesis of E-series 18(R)-resolvins";"Synthesis of Leukotrienes (LT) and Eoxins (EX)";"Biosynthesis of D-series resolvins";"Neutrophil degranulation";"Biosynthesis of aspirin-triggered D-series resolvins";"Biosynthesis of protectins"
XP_046413610.1	3	Reactome: R-HSA-212676;Reactome: R-HSA-6794361;Reactome: R-HSA-9609736	"Dopamine Neurotransmitter Release Cycle";"Neurexins and neuroligins";"Assembly and cell surface presentation of NMDA receptors"
XP_046434720.1	4	Reactome: R-HSA-2173788;Reactome: R-HSA-3304356;Reactome: R-HSA-3656532;Reactome: R-HSA-2173789	"Downregulation of TGF-beta receptor signaling";"SMAD2/3 Phosphorylation Motif Mutants in Cancer";"TGFBR1 KD Mutants in Cancer";"TGF-beta receptor signaling activates SMADs"
XP_046420961.1	5	Reactome: R-HSA-69473;Reactome: R-HSA-5693571;Reactome: R-HSA-5689901;Reactome: R-HSA-5693607;Reactome: R-HSA-5693565	"G2/M DNA damage checkpoint";"Nonhomologous End-Joining (NHEJ)";"Metalloprotease DUBs";"Processing of DNA double-strand break ends";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"
XP_046420194.1	3	Reactome: R-HSA-416482;Reactome: R-HSA-194840;Reactome: R-HSA-193648	"G alpha (12/13) signalling events";"Rho GTPase cycle";"NRAGE signals death through JNK"
XP_046431229.1	2	Reactome: R-HSA-6798695;Reactome: R-HSA-8964038	"Neutrophil degranulation";"LDL clearance"
XP_046413298.1	4	Reactome: R-HSA-5689880;Reactome: R-HSA-201681;Reactome: R-HSA-418594;Reactome: R-HSA-4641257	"Ub-specific processing proteases";"TCF dependent signaling in response to WNT";"G alpha (i) signalling events";"Degradation of AXIN"
XP_046425359.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_046412310.1	4	Reactome: R-HSA-5656121;Reactome: R-HSA-5656169;Reactome: R-HSA-5655862;Reactome: R-HSA-110312	"Translesion synthesis by POLI";"Termination of translesion DNA synthesis";"Translesion synthesis by POLK";"Translesion synthesis by REV1"
XP_046432986.1	3	Reactome: R-HSA-212436;Reactome: R-HSA-381340;Reactome: R-HSA-1989781	"Generic Transcription Pathway";"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression"
XP_046426623.1	4	Reactome: R-HSA-6814122;Reactome: R-HSA-418594;Reactome: R-HSA-202040;Reactome: R-HSA-112043	"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"G alpha (i) signalling events";"G-protein activation";"PLC beta mediated events"
XP_046411757.1	1	KEGG: 00480+3.4.11.2	"Glutathione metabolism"
XP_046436323.1	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
XP_046419248.1	1	Reactome: R-HSA-352230	"Amino acid transport across the plasma membrane"
XP_046421016.1	6	MetaCyc: PWY-5884;MetaCyc: PWY-7782;KEGG: 00073+1.2.1.84;MetaCyc: PWY-7656;MetaCyc: PWY-6733;Reactome: R-HSA-9640463	"Wax esters biosynthesis I";"Plasmalogen biosynthesis";"Cutin, suberine and wax biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Sporopollenin precursors biosynthesis";"Wax biosynthesis"
XP_046428499.1	6	Reactome: R-HSA-381033;Reactome: R-HSA-1655829;Reactome: R-HSA-8874211;Reactome: R-HSA-8957275;Reactome: R-HSA-381426;Reactome: R-HSA-8963889	"ATF6 (ATF6-alpha) activates chaperones";"Regulation of cholesterol biosynthesis by SREBP (SREBF)";"CREB3 factors activate genes";"Post-translational protein phosphorylation";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"Assembly of active LPL and LIPC lipase complexes"
XP_046433940.1	5	Reactome: R-HSA-72163;Reactome: R-HSA-6782210;Reactome: R-HSA-6782135;Reactome: R-HSA-6781823;Reactome: R-HSA-6781827	"mRNA Splicing - Major Pathway";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Dual incision in TC-NER";"Formation of TC-NER Pre-Incision Complex";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)"
XP_046409578.1	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
XP_046429422.1	1	Reactome: R-HSA-5625900	"RHO GTPases activate CIT"
XP_046427734.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_046416262.1	2	Reactome: R-HSA-74217;KEGG: 00230+1.7.1.7	"Purine salvage";"Purine metabolism"
XP_046417870.1	12	MetaCyc: PWY-1042;KEGG: 00051+4.1.2.13;MetaCyc: PWY-7385;KEGG: 00680+4.1.2.13;Reactome: R-HSA-70171;MetaCyc: PWY-1861;MetaCyc: PWY-5484;KEGG: 00010+4.1.2.13;Reactome: R-HSA-70263;MetaCyc: PWY-6142;KEGG: 00710+4.1.2.13;KEGG: 00030+4.1.2.13	"Glycolysis IV (plant cytosol)";"Fructose and mannose metabolism";"1,3-propanediol biosynthesis (engineered)";"Methane metabolism";"Glycolysis";"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"Glycolysis II (from fructose 6-phosphate)";"Glycolysis / Gluconeogenesis";"Gluconeogenesis";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Carbon fixation in photosynthetic organisms";"Pentose phosphate pathway"
XP_046435960.1	1	Reactome: R-HSA-9018519	"Estrogen-dependent gene expression"
XP_046435355.1	1	Reactome: R-HSA-1660661	"Sphingolipid de novo biosynthesis"
XP_046419500.1	3	Reactome: R-HSA-3000171;Reactome: R-HSA-8874081;Reactome: R-HSA-3000157	"Non-integrin membrane-ECM interactions";"MET activates PTK2 signaling";"Laminin interactions"
XP_046432825.1	3	Reactome: R-HSA-5576890;Reactome: R-HSA-1296072;Reactome: R-HSA-5576893	"Phase 3 - rapid repolarisation";"Voltage gated Potassium channels";"Phase 2 - plateau phase"
XP_046417090.1	1	Reactome: R-HSA-5576886	"Phase 4 - resting membrane potential"
XP_046417042.1	3	Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-212436	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"Generic Transcription Pathway"
XP_046409774.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_046428804.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_046428258.1	3	Reactome: R-HSA-2029482;Reactome: R-HSA-5663213;Reactome: R-HSA-4420097	"Regulation of actin dynamics for phagocytic cup formation";"RHO GTPases Activate WASPs and WAVEs";"VEGFA-VEGFR2 Pathway"
XP_046410367.1	2	Reactome: R-HSA-6811436;Reactome: R-HSA-8876198	"COPI-independent Golgi-to-ER retrograde traffic";"RAB GEFs exchange GTP for GDP on RABs"
XP_046413056.1	1	Reactome: R-HSA-6811440	"Retrograde transport at the Trans-Golgi-Network"
XP_046409409.1	2	Reactome: R-HSA-375276;Reactome: R-HSA-416476	"Peptide ligand-binding receptors";"G alpha (q) signalling events"
XP_046433520.1	1	Reactome: R-HSA-391908	"Prostanoid ligand receptors"
XP_046415481.1	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
XP_046432136.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_046433140.1	1	Reactome: R-HSA-8949664	"Processing of SMDT1"
XP_046409415.1	2	Reactome: R-HSA-416476;Reactome: R-HSA-375276	"G alpha (q) signalling events";"Peptide ligand-binding receptors"
XP_046410287.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046432375.1	2	Reactome: R-HSA-5693568;Reactome: R-HSA-6783310	"Resolution of D-loop Structures through Holliday Junction Intermediates";"Fanconi Anemia Pathway"
XP_046409498.1	1	Reactome: R-HSA-425366	"Transport of bile salts and organic acids, metal ions and amine compounds"
XP_046421796.1	2	Reactome: R-HSA-5689603;Reactome: R-HSA-5696394	"UCH proteinases";"DNA Damage Recognition in GG-NER"
XP_046432053.1	1	KEGG: 00531+3.2.1.35	"Glycosaminoglycan degradation"
XP_046424929.1	1	Reactome: R-HSA-432720	"Lysosome Vesicle Biogenesis"
XP_046428859.1	4	KEGG: 00564+3.1.1.32;MetaCyc: PWY-6803;MetaCyc: PWY-8051;KEGG: 00592+3.1.1.32	"Glycerophospholipid metabolism";"Phosphatidylcholine acyl editing";"Anandamide biosynthesis I";"alpha-Linolenic acid metabolism"
XP_046420912.1	2	Reactome: R-HSA-3214841;Reactome: R-HSA-8936459	"PKMTs methylate histone lysines";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"
XP_046411659.1	2	Reactome: R-HSA-1169408;Reactome: R-HSA-168276	"ISG15 antiviral mechanism";"NS1 Mediated Effects on Host Pathways"
XP_046425912.1	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
XP_046410810.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046429087.1	13	MetaCyc: PWY-6859;MetaCyc: PWY-7102;MetaCyc: PWY-7182;MetaCyc: PWY-7410;MetaCyc: PWY-7721;MetaCyc: PWY-5122;MetaCyc: PWY-7141;MetaCyc: PWY-7659;MetaCyc: PWY-7709;MetaCyc: PWY-6383;KEGG: 00900+2.5.1.10+2.5.1.1;MetaCyc: PWY-5123;MetaCyc: PWY-7736	"All-trans-farnesol biosynthesis";"Bisabolene biosynthesis (engineered)";"Linalool biosynthesis I";"Ipsdienol biosynthesis";"Methyl phomopsenoate biosynthesis";"Geranyl diphosphate biosynthesis";"(3S)-linalool biosynthesis";"Viridicatumtoxin biosynthesis";"(3R)-linalool biosynthesis";"Mono-trans, poly-cis decaprenyl phosphate biosynthesis";"Terpenoid backbone biosynthesis";"Trans, trans-farnesyl diphosphate biosynthesis";"Stellatic acid biosynthesis"
XP_046414392.1	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046422589.1	3	Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-212436	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"Generic Transcription Pathway"
XP_046418829.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046433839.1	1	Reactome: R-HSA-1474228	"Degradation of the extracellular matrix"
XP_046429021.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046434007.1	1	Reactome: R-HSA-5662702	"Melanin biosynthesis"
XP_046420057.1	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
XP_046422451.1	2	Reactome: R-HSA-416476;Reactome: R-HSA-388479	"G alpha (q) signalling events";"Vasopressin-like receptors"
XP_046416479.1	2	KEGG: 00970+6.3.5.7;Reactome: R-HSA-2142753	"Aminoacyl-tRNA biosynthesis";"Arachidonic acid metabolism"
XP_046433040.1	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
XP_046412976.1	8	Reactome: R-HSA-5083633;KEGG: 00515+2.4.1.109;MetaCyc: PWY-7979;KEGG: 00514+2.4.1.109;MetaCyc: PWY-7921;MetaCyc: PWY-7922;Reactome: R-HSA-5173105;Reactome: R-HSA-5083629	"Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1";"Mannose type O-glycan biosynthesis";"Protein O-mannosylation III (mammals, core M3)";"Other types of O-glycan biosynthesis";"Protein O-mannosylation I (yeast)";"Protein O-mannosylation II (mammals, core M1 and core M2)";"O-linked glycosylation";"Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2"
XP_046409751.1	8	Reactome: R-HSA-69166;Reactome: R-HSA-174411;Reactome: R-HSA-68962;Reactome: R-HSA-69183;Reactome: R-HSA-174430;Reactome: R-HSA-68952;Reactome: R-HSA-113501;Reactome: R-HSA-69091	"Removal of the Flap Intermediate";"Polymerase switching on the C-strand of the telomere";"Activation of the pre-replicative complex";"Processive synthesis on the lagging strand";"Telomere C-strand synthesis initiation";"DNA replication initiation";"Inhibition of replication initiation of damaged DNA by RB1/E2F1";"Polymerase switching"
XP_046416119.1	3	Reactome: R-HSA-6811440;Reactome: R-HSA-6807878;Reactome: R-HSA-6811438	"Retrograde transport at the Trans-Golgi-Network";"COPI-mediated anterograde transport";"Intra-Golgi traffic"
XP_046413667.1	6	MetaCyc: PWY-5884;MetaCyc: PWY-7782;MetaCyc: PWY-7656;KEGG: 00073+1.2.1.84;Reactome: R-HSA-9640463;MetaCyc: PWY-6733	"Wax esters biosynthesis I";"Plasmalogen biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax biosynthesis";"Sporopollenin precursors biosynthesis"
XP_046411008.1	5	Reactome: R-HSA-6798695;KEGG: 00860+4.2.1.24;MetaCyc: PWY-5188;Reactome: R-HSA-189451;MetaCyc: PWY-5189	"Neutrophil degranulation";"Porphyrin and chlorophyll metabolism";"Tetrapyrrole biosynthesis I (from glutamate)";"Heme biosynthesis";"Tetrapyrrole biosynthesis II (from glycine)"
XP_046413213.1	7	KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1	"Relaxin signaling pathway";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Human cytomegalovirus infection";"Thermogenesis";"PI3K-Akt signaling pathway";"mTOR signaling pathway"
XP_046421526.1	3	MetaCyc: PWY-6857;Reactome: R-HSA-192456;KEGG: 00561+3.1.1.3	"Retinol biosynthesis";"Digestion of dietary lipid";"Glycerolipid metabolism"
XP_046432966.1	1	Reactome: R-HSA-435368	"Zinc efflux and compartmentalization by the SLC30 family"
XP_046420230.1	10	Reactome: R-HSA-9615017;Reactome: R-HSA-400206;Reactome: R-HSA-9022702;Reactome: R-HSA-8936459;Reactome: R-HSA-9022692;Reactome: R-HSA-3899300;Reactome: R-HSA-9022538;Reactome: R-HSA-9022699;Reactome: R-HSA-983231;Reactome: R-HSA-427413	"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"Regulation of lipid metabolism by PPARalpha";"MECP2 regulates transcription of neuronal ligands";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Regulation of MECP2 expression and activity";"SUMOylation of transcription cofactors";"Loss of MECP2 binding ability to 5mC-DNA";"MECP2 regulates neuronal receptors and channels";"Factors involved in megakaryocyte development and platelet production";"NoRC negatively regulates rRNA expression"
XP_046430775.1	1	Reactome: R-HSA-6809371	"Formation of the cornified envelope"
XP_046414742.1	1	Reactome: R-HSA-425986	"Sodium/Proton exchangers"
XP_046421002.1	1	Reactome: R-HSA-432047	"Passive transport by Aquaporins"
XP_046433590.1	2	Reactome: R-HSA-5619061;Reactome: R-HSA-425397	"Defective SLC33A1 causes spastic paraplegia 42 (SPG42)";"Transport of vitamins, nucleosides, and related molecules"
XP_046416692.1	5	Reactome: R-HSA-1257604;Reactome: R-HSA-6804757;Reactome: R-HSA-5674400;Reactome: R-HSA-5218920;Reactome: R-HSA-389357	"PIP3 activates AKT signaling";"Regulation of TP53 Degradation";"Constitutive Signaling by AKT1 E17K in Cancer";"VEGFR2 mediated vascular permeability";"CD28 dependent PI3K/Akt signaling"
XP_046436675.1	12	Reactome: R-HSA-2132295;Reactome: R-HSA-68877;Reactome: R-HSA-9609690;Reactome: R-HSA-9646399;Reactome: R-HSA-2467813;Reactome: R-HSA-6811436;Reactome: R-HSA-9648025;Reactome: R-HSA-141444;Reactome: R-HSA-5663220;Reactome: R-HSA-2500257;Reactome: R-HSA-6807878;Reactome: R-HSA-3371497	"MHC class II antigen presentation";"Mitotic Prometaphase";"HCMV Early Events";"Aggrephagy";"Separation of Sister Chromatids";"COPI-independent Golgi-to-ER retrograde traffic";"EML4 and NUDC in mitotic spindle formation";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"RHO GTPases Activate Formins";"Resolution of Sister Chromatid Cohesion";"COPI-mediated anterograde transport";"HSP90 chaperone cycle for steroid hormone receptors (SHR)"
XP_046419775.1	1	Reactome: R-HSA-390522	"Striated Muscle Contraction"
XP_046410876.1	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
XP_046421722.1	5	Reactome: R-HSA-389661;KEGG: 00250+1.2.1.88;Reactome: R-HSA-70688;MetaCyc: PWY-6853;KEGG: 00330+1.2.1.88	"Glyoxylate metabolism and glycine degradation";"Alanine, aspartate and glutamate metabolism";"Proline catabolism";"Ethylene biosynthesis II (microbes)";"Arginine and proline metabolism"
XP_046414124.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_046425973.1	1	Reactome: R-HSA-3214842	"HDMs demethylate histones"
XP_046436272.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046429454.1	1	Reactome: R-HSA-419771	"Opsins"
XP_046433828.1	7	KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1	"Thermogenesis";"Human cytomegalovirus infection";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Relaxin signaling pathway";"mTOR signaling pathway";"PI3K-Akt signaling pathway"
XP_046425845.1	1	Reactome: R-HSA-71064	"Lysine catabolism"
XP_046433418.1	3	Reactome: R-HSA-1989781;Reactome: R-HSA-381340;Reactome: R-HSA-212436	"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation";"Generic Transcription Pathway"
XP_046420032.1	2	Reactome: R-HSA-163210;Reactome: R-HSA-8949613	"Formation of ATP by chemiosmotic coupling";"Cristae formation"
XP_046414696.1	2	Reactome: R-HSA-375276;Reactome: R-HSA-418594	"Peptide ligand-binding receptors";"G alpha (i) signalling events"
XP_046413813.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046413841.1	16	Reactome: R-HSA-176412;Reactome: R-HSA-179409;Reactome: R-HSA-174048;Reactome: R-HSA-176409;Reactome: R-HSA-8853884;Reactome: R-HSA-174084;Reactome: R-HSA-174178;Reactome: R-HSA-2559582;Reactome: R-HSA-2467813;Reactome: R-HSA-69017;Reactome: R-HSA-174154;Reactome: R-HSA-174184;Reactome: R-HSA-176408;Reactome: R-HSA-176407;Reactome: R-HSA-141430;Reactome: R-HSA-983168	"Phosphorylation of the APC/C";"APC-Cdc20 mediated degradation of Nek2A";"APC/C:Cdc20 mediated degradation of Cyclin B";"APC/C:Cdc20 mediated degradation of mitotic proteins";"Transcriptional Regulation by VENTX";"Autodegradation of Cdh1 by Cdh1:APC/C";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Senescence-Associated Secretory Phenotype (SASP)";"Separation of Sister Chromatids";"CDK-mediated phosphorylation and removal of Cdc6";"APC/C:Cdc20 mediated degradation of Securin";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Regulation of APC/C activators between G1/S and early anaphase";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"Inactivation of APC/C via direct inhibition of the APC/C complex";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046418386.1	1	Reactome: R-HSA-1483191	"Synthesis of PC"
XP_046429083.1	13	MetaCyc: PWY-7410;MetaCyc: PWY-7182;MetaCyc: PWY-6859;MetaCyc: PWY-7102;MetaCyc: PWY-7736;MetaCyc: PWY-5123;KEGG: 00900+2.5.1.10+2.5.1.1;MetaCyc: PWY-7709;MetaCyc: PWY-6383;MetaCyc: PWY-7659;MetaCyc: PWY-7141;MetaCyc: PWY-5122;MetaCyc: PWY-7721	"Ipsdienol biosynthesis";"Linalool biosynthesis I";"All-trans-farnesol biosynthesis";"Bisabolene biosynthesis (engineered)";"Stellatic acid biosynthesis";"Trans, trans-farnesyl diphosphate biosynthesis";"Terpenoid backbone biosynthesis";"(3R)-linalool biosynthesis";"Mono-trans, poly-cis decaprenyl phosphate biosynthesis";"Viridicatumtoxin biosynthesis";"(3S)-linalool biosynthesis";"Geranyl diphosphate biosynthesis";"Methyl phomopsenoate biosynthesis"
XP_046435532.1	2	Reactome: R-HSA-400253;Reactome: R-HSA-2151201	"Circadian Clock";"Transcriptional activation of mitochondrial biogenesis"
XP_046420371.1	3	Reactome: R-HSA-8964058;Reactome: R-HSA-9029569;Reactome: R-HSA-1369062	"HDL remodeling";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"ABC transporters in lipid homeostasis"
XP_046435586.1	6	Reactome: R-HSA-5609978;KEGG: 00052+2.7.7.12;MetaCyc: PWY-6527;KEGG: 00520+2.7.7.12;Reactome: R-HSA-70370;MetaCyc: PWY-6317	"Defective GALT can cause Galactosemia";"Galactose metabolism";"Stachyose degradation";"Amino sugar and nucleotide sugar metabolism";"Galactose catabolism";"D-galactose degradation I (Leloir pathway)"
XP_046410343.1	1	Reactome: R-HSA-5620912	"Anchoring of the basal body to the plasma membrane"
XP_046420696.1	1	Reactome: R-HSA-169911	"Regulation of Apoptosis"
XP_046419873.1	19	Reactome: R-HSA-3371571;Reactome: R-HSA-9649948;Reactome: R-HSA-6802952;Reactome: R-HSA-442982;Reactome: R-HSA-6802955;Reactome: R-HSA-6802946;Reactome: R-HSA-5673000;Reactome: R-HSA-9620244;Reactome: R-HSA-5673001;Reactome: R-HSA-9609736;Reactome: R-HSA-399719;Reactome: R-HSA-5578775;Reactome: R-HSA-936837;Reactome: R-HSA-877300;Reactome: R-HSA-5576892;Reactome: R-HSA-9617324;Reactome: R-HSA-438066;Reactome: R-HSA-111932;Reactome: R-HSA-9022692	"HSF1-dependent transactivation";"Signaling downstream of RAS mutants";"Signaling by BRAF and RAF fusions";"Ras activation upon Ca2+ influx through NMDA receptor";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"Signaling by moderate kinase activity BRAF mutants";"RAF activation";"Long-term potentiation";"RAF/MAP kinase cascade";"Assembly and cell surface presentation of NMDA receptors";"Trafficking of AMPA receptors";"Ion homeostasis";"Ion transport by P-type ATPases";"Interferon gamma signaling";"Phase 0 - rapid depolarisation";"Negative regulation of NMDA receptor-mediated neuronal transmission";"Unblocking of NMDA receptors, glutamate binding and activation";"CaMK IV-mediated phosphorylation of CREB";"Regulation of MECP2 expression and activity"
XP_046421513.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046435324.1	3	KEGG: 00740+3.1.3.2;MetaCyc: PWY-6348;KEGG: 00730+3.1.3.2	"Riboflavin metabolism";"Phosphate acquisition";"Thiamine metabolism"
XP_046427621.1	1	Reactome: R-HSA-3214842	"HDMs demethylate histones"
XP_046422103.1	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
XP_046423468.1	2	Reactome: R-HSA-9029569;Reactome: R-HSA-804914	"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Transport of fatty acids"
XP_046418836.1	1	Reactome: R-HSA-83936	"Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"
XP_046432718.1	6	Reactome: R-HSA-975578;KEGG: 00513+2.4.1.143;MetaCyc: PWY-7920;Reactome: R-HSA-4793952;MetaCyc: PWY-7426;KEGG: 00510+2.4.1.143	"Reactions specific to the complex N-glycan synthesis pathway";"Various types of N-glycan biosynthesis";"Complex N-linked glycan biosynthesis (plants)";"Defective MGAT2 causes MGAT2-CDG (CDG-2a)";"Complex N-linked glycan biosynthesis (vertebrates)";"N-Glycan biosynthesis"
XP_046435699.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046424021.1	8	Reactome: R-HSA-428540;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1	"Activation of RAC1";"Human cytomegalovirus infection";"Relaxin signaling pathway";"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Thermogenesis";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection"
XP_046425958.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046436664.1	4	Reactome: R-HSA-379716;KEGG: 00970+6.1.1.18;Reactome: R-HSA-2408522;Reactome: R-HSA-379726	"Cytosolic tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis";"Selenoamino acid metabolism";"Mitochondrial tRNA aminoacylation"
XP_046429505.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_046432558.1	1	Reactome: R-HSA-191859	"snRNP Assembly"
XP_046425365.1	2	Reactome: R-HSA-917729;Reactome: R-HSA-162588	"Endosomal Sorting Complex Required For Transport (ESCRT)";"Budding and maturation of HIV virion"
XP_046432085.1	7	KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1	"Thermogenesis";"Human cytomegalovirus infection";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Relaxin signaling pathway";"mTOR signaling pathway";"PI3K-Akt signaling pathway"
XP_046427159.1	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
XP_046427268.1	8	KEGG: 00240+3.5.4.5;KEGG: 00983+3.5.4.5;MetaCyc: PWY-7181;MetaCyc: PWY-7193;Reactome: R-HSA-6798695;Reactome: R-HSA-73614;MetaCyc: PWY-7199;MetaCyc: PWY-6556	"Pyrimidine metabolism";"Drug metabolism - other enzymes";"Pyrimidine deoxyribonucleosides degradation";"Pyrimidine ribonucleosides salvage I";"Neutrophil degranulation";"Pyrimidine salvage";"Pyrimidine deoxyribonucleosides salvage";"Pyrimidine ribonucleosides salvage II"
XP_046426577.1	2	Reactome: R-HSA-1296072;Reactome: R-HSA-5576894	"Voltage gated Potassium channels";"Phase 1 - inactivation of fast Na+ channels"
XP_046414359.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046430077.1	1	Reactome: R-HSA-70171	"Glycolysis"
XP_046424801.1	4	Reactome: R-HSA-912631;Reactome: R-HSA-8875656;Reactome: R-HSA-8875555;Reactome: R-HSA-186763	"Regulation of signaling by CBL";"MET receptor recycling";"MET activates RAP1 and RAC1";"Downstream signal transduction"
XP_046432032.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_046421492.1	1	Reactome: R-HSA-2299718	"Condensation of Prophase Chromosomes"
XP_046427607.1	1	Reactome: R-HSA-72203	"Processing of Capped Intron-Containing Pre-mRNA"
XP_046422291.1	13	Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-192823;Reactome: R-HSA-9633012;Reactome: R-HSA-72689;Reactome: R-HSA-1799339;Reactome: R-HSA-72706;Reactome: R-HSA-2408557;Reactome: R-HSA-6791226;Reactome: R-HSA-975957;Reactome: R-HSA-72764;Reactome: R-HSA-156902;Reactome: R-HSA-975956	"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Viral mRNA Translation";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Formation of a pool of free 40S subunits";"SRP-dependent cotranslational protein targeting to membrane";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Selenocysteine synthesis";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"
XP_046431420.1	3	KEGG: 00230+4.6.1.2;Reactome: R-HSA-445355;Reactome: R-HSA-392154	"Purine metabolism";"Smooth Muscle Contraction";"Nitric oxide stimulates guanylate cyclase"
XP_046417700.1	8	Reactome: R-HSA-6791461;Reactome: R-HSA-5659996;MetaCyc: PWY-5723;KEGG: 00710+5.3.1.6;Reactome: R-HSA-71336;KEGG: 00030+5.3.1.6;KEGG: 00051+5.3.1.6;MetaCyc: PWY-1861	"RPIA deficiency: failed conversion of RU5P to R5P";"RPIA deficiency: failed conversion of R5P to RU5P";"Rubisco shunt";"Carbon fixation in photosynthetic organisms";"Pentose phosphate pathway";"Pentose phosphate pathway";"Fructose and mannose metabolism";"Formaldehyde assimilation II (assimilatory RuMP Cycle)"
XP_046413545.1	1	Reactome: R-HSA-5620912	"Anchoring of the basal body to the plasma membrane"
XP_046425982.1	1	Reactome: R-HSA-399956	"CRMPs in Sema3A signaling"
XP_046420925.1	1	Reactome: R-HSA-201681	"TCF dependent signaling in response to WNT"
XP_046420545.1	2	Reactome: R-HSA-383280;Reactome: R-HSA-983231	"Nuclear Receptor transcription pathway";"Factors involved in megakaryocyte development and platelet production"
XP_046411697.1	1	Reactome: R-HSA-5685939	"HDR through MMEJ (alt-NHEJ)"
XP_046417259.1	1	KEGG: 00760+2.3.1.286	"Nicotinate and nicotinamide metabolism"
XP_046414185.1	1	Reactome: R-HSA-1660662	"Glycosphingolipid metabolism"
XP_046428890.1	20	MetaCyc: PWY-7858;MetaCyc: PWY-7291;MetaCyc: PWY-6920;KEGG: 00071+1.3.3.6;MetaCyc: PWY-7338;MetaCyc: PWY-735;KEGG: 00592+1.3.3.6;KEGG: 00640+1.3.3.6;MetaCyc: PWY-6837;KEGG: 00410+1.3.3.6;Reactome: R-HSA-9033241;MetaCyc: PWY-5136;MetaCyc: PWY-7854;MetaCyc: PWY-7007;MetaCyc: PWY-7606;MetaCyc: PWY-7726;MetaCyc: PWY-7288;MetaCyc: PWY-7340;MetaCyc: PWY-7574;MetaCyc: PWY-7337	"(5Z)-dodecenoate biosynthesis II";"Oleate beta-oxidation (isomerase-dependent, yeast)";"6-gingerol analog biosynthesis (engineered)";"Fatty acid degradation";"10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast)";"Jasmonic acid biosynthesis";"alpha-Linolenic acid metabolism";"Propanoate metabolism";"Fatty acid beta-oxidation V (unsaturated, odd number, di-isomerase-dependent)";"beta-Alanine metabolism";"Peroxisomal protein import";"Fatty acid beta-oxidation II (plant peroxisome)";"Crotonyl-coa/ethylmalonyl-coa/hydroxybutyryl-coa cycle (engineered)";"Methyl ketone biosynthesis (engineered)";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"Fatty acid beta-oxidation VII (yeast peroxisome)";"9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast)";"Propanoyl-coa degradation II";"10-cis-heptadecenoyl-CoA degradation (yeast)"
XP_046418882.1	8	Reactome: R-HSA-983231;Reactome: R-HSA-432040;Reactome: R-HSA-442720;Reactome: R-HSA-381676;Reactome: R-HSA-180024;Reactome: R-HSA-5610787;Reactome: R-HSA-163615;Reactome: R-HSA-164378	"Factors involved in megakaryocyte development and platelet production";"Vasopressin regulates renal water homeostasis via Aquaporins";"CREB1 phosphorylation through the activation of Adenylate Cyclase";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"DARPP-32 events";"Hedgehog 'off' state";"PKA activation";"PKA activation in glucagon signalling"
XP_046426401.1	1	KEGG: 00970+6.1.1.16	"Aminoacyl-tRNA biosynthesis"
XP_046410019.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_046419119.1	1	Reactome: R-HSA-382556	"ABC-family proteins mediated transport"
XP_046431176.1	2	Reactome: R-HSA-6811434;Reactome: R-HSA-6807878	"COPI-dependent Golgi-to-ER retrograde traffic";"COPI-mediated anterograde transport"
XP_046418038.1	8	Reactome: R-HSA-68962;Reactome: R-HSA-68949;Reactome: R-HSA-68827;Reactome: R-HSA-176187;Reactome: R-HSA-68689;Reactome: R-HSA-113507;Reactome: R-HSA-68616;Reactome: R-HSA-68867	"Activation of the pre-replicative complex";"Orc1 removal from chromatin";"CDT1 association with the CDC6:ORC:origin complex";"Activation of ATR in response to replication stress";"CDC6 association with the ORC:origin complex";"E2F-enabled inhibition of pre-replication complex formation";"Assembly of the ORC complex at the origin of replication";"Assembly of the pre-replicative complex"
XP_046410832.1	6	Reactome: R-HSA-6785807;Reactome: R-HSA-452723;Reactome: R-HSA-8986944;Reactome: R-HSA-3769402;Reactome: R-HSA-2892245;Reactome: R-HSA-2892247	"Interleukin-4 and Interleukin-13 signaling";"Transcriptional regulation of pluripotent stem cells";"Transcriptional Regulation by MECP2";"Deactivation of the beta-catenin transactivating complex";"POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation";"POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation"
XP_046411251.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_046428577.1	3	Reactome: R-HSA-193648;Reactome: R-HSA-416482;Reactome: R-HSA-194840	"NRAGE signals death through JNK";"G alpha (12/13) signalling events";"Rho GTPase cycle"
XP_046425411.1	2	Reactome: R-HSA-8856825;Reactome: R-HSA-8856828	"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis"
XP_046426122.1	1	Reactome: R-HSA-5658442	"Regulation of RAS by GAPs"
XP_046413680.1	13	Reactome: R-HSA-72689;Reactome: R-HSA-9633012;Reactome: R-HSA-192823;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-2408557;Reactome: R-HSA-72706;Reactome: R-HSA-1799339;Reactome: R-HSA-975957;Reactome: R-HSA-6791226;Reactome: R-HSA-975956;Reactome: R-HSA-156902;Reactome: R-HSA-72764	"Formation of a pool of free 40S subunits";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Selenocysteine synthesis";"GTP hydrolysis and joining of the 60S ribosomal subunit";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Peptide chain elongation";"Eukaryotic Translation Termination"
XP_046431480.1	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286	"Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation"
XP_046431042.1	3	KEGG: 00230+2.7.4.8;Reactome: R-HSA-420029;MetaCyc: PWY-7221	"Purine metabolism";"Tight junction interactions";"Guanosine ribonucleotides de novo biosynthesis"
XP_046425285.1	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
XP_046420474.1	33	KEGG: 00980+1.1.1.1;KEGG: 00260+1.1.1.1;MetaCyc: PWY-6871;MetaCyc: PWY-3162;KEGG: 00680+1.1.1.284;MetaCyc: PWY-5078;KEGG: 00982+1.1.1.1;MetaCyc: PWY-6333;MetaCyc: PWY-6802;MetaCyc: PWY-5751;MetaCyc: PWY-5082;Reactome: R-HSA-71384;MetaCyc: PWY-7798;MetaCyc: PWY-5057;MetaCyc: PWY-7118;KEGG: 00625+1.1.1.1;KEGG: 00592+1.1.1.1;MetaCyc: PWY-6587;MetaCyc: PWY-6313;MetaCyc: PWY-5486;MetaCyc: PWY-1801;MetaCyc: PWY-7013;MetaCyc: PWY-5480;MetaCyc: PWY-6342;KEGG: 00071+1.1.1.1;MetaCyc: PWY-7111;MetaCyc: PWY-5076;KEGG: 00626+1.1.1.1;KEGG: 00010+1.1.1.1;MetaCyc: PWY-5079;KEGG: 00350+1.1.1.1;KEGG: 00830+1.1.1.1;MetaCyc: PWY-7396	"Metabolism of xenobiotics by cytochrome P450";"Glycine, serine and threonine metabolism";"3-methylbutanol biosynthesis (engineered)";"L-tryptophan degradation V (side chain pathway)";"Methane metabolism";"L-isoleucine degradation II";"Drug metabolism - cytochrome P450";"Acetaldehyde biosynthesis I";"Salidroside biosynthesis";"Phenylethanol biosynthesis";"L-methionine degradation III";"Ethanol oxidation";"Protein S-nitrosylation and denitrosylation";"L-valine degradation II";"Chitin degradation to ethanol";"Chloroalkane and chloroalkene degradation";"alpha-Linolenic acid metabolism";"Pyruvate fermentation to ethanol III";"Serotonin degradation";"Pyruvate fermentation to ethanol II";"Formaldehyde oxidation II (glutathione-dependent)";"(S)-propane-1,2-diol degradation";"Pyruvate fermentation to ethanol I";"Noradrenaline and adrenaline degradation";"Fatty acid degradation";"Pyruvate fermentation to isobutanol (engineered)";"L-leucine degradation III";"Naphthalene degradation";"Glycolysis / Gluconeogenesis";"L-phenylalanine degradation III";"Tyrosine metabolism";"Retinol metabolism";"Butanol and isobutanol biosynthesis (engineered)"
XP_046428755.1	5	Reactome: R-HSA-166166;Reactome: R-HSA-937072;Reactome: R-HSA-936964;Reactome: R-HSA-937041;Reactome: R-HSA-168164	"MyD88-independent TLR4 cascade";"TRAF6-mediated induction of TAK1 complex within TLR4 complex";"Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon";"IKK complex recruitment mediated by RIP1";"Toll Like Receptor 3 (TLR3) Cascade"
XP_046436623.1	1	Reactome: R-HSA-2428928	"IRS-related events triggered by IGF1R"
XP_046411685.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_046410101.1	7	MetaCyc: PWY-7295;KEGG: 00630+2.3.3.9;MetaCyc: PWY-6969;KEGG: 00620+2.3.3.9;MetaCyc: PWY-7118;MetaCyc: PWY-7854;MetaCyc: PWY-7294	"L-arabinose degradation IV";"Glyoxylate and dicarboxylate metabolism";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Pyruvate metabolism";"Chitin degradation to ethanol";"Crotonyl-coa/ethylmalonyl-coa/hydroxybutyryl-coa cycle (engineered)";"D-xylose degradation IV"
XP_046429565.1	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
XP_046426630.1	1	MetaCyc: PWY-6829	"Trna methylation (yeast)"
XP_046418232.1	3	Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-212436	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"Generic Transcription Pathway"
XP_046430774.1	1	Reactome: R-HSA-6809371	"Formation of the cornified envelope"
XP_046416631.1	7	Reactome: R-HSA-4641258;Reactome: R-HSA-4641262;Reactome: R-HSA-5663220;Reactome: R-HSA-5368598;Reactome: R-HSA-201681;Reactome: R-HSA-201688;Reactome: R-HSA-4086400	"Degradation of DVL";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"RHO GTPases Activate Formins";"Negative regulation of TCF-dependent signaling by DVL-interacting proteins";"TCF dependent signaling in response to WNT";"WNT mediated activation of DVL";"PCP/CE pathway"
XP_046421604.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046414116.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_046418123.1	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046436428.1	4	MetaCyc: PWY-6902;MetaCyc: PWY-6855;MetaCyc: PWY-7822;KEGG: 00520+3.2.1.14	"Chitin degradation II (Vibrio)";"Chitin degradation I (archaea)";"Chitin degradation III (Serratia)";"Amino sugar and nucleotide sugar metabolism"
XP_046432853.1	1	Reactome: R-HSA-9603798	"Class I peroxisomal membrane protein import"
XP_046416503.1	2	KEGG: 00670+2.1.2.10;KEGG: 00260+2.1.2.10	"One carbon pool by folate";"Glycine, serine and threonine metabolism"
XP_046418729.1	16	Reactome: R-HSA-167246;Reactome: R-HSA-8951664;Reactome: R-HSA-167238;Reactome: R-HSA-180585;Reactome: R-HSA-167287;Reactome: R-HSA-1234176;Reactome: R-HSA-983168;Reactome: R-HSA-75955;Reactome: R-HSA-112382;Reactome: R-HSA-9010553;Reactome: R-HSA-167243;Reactome: R-HSA-674695;Reactome: R-HSA-167200;Reactome: R-HSA-6796648;Reactome: R-HSA-167290;Reactome: R-HSA-167152	"Tat-mediated elongation of the HIV-1 transcript";"Neddylation";"Pausing and recovery of Tat-mediated HIV elongation";"Vif-mediated degradation of APOBEC3G";"HIV elongation arrest and recovery";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Antigen processing: Ubiquitination & Proteasome degradation";"RNA Polymerase II Transcription Elongation";"Formation of RNA Pol II elongation complex";"Regulation of expression of SLITs and ROBOs";"Tat-mediated HIV elongation arrest and recovery";"RNA Polymerase II Pre-transcription Events";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"TP53 Regulates Transcription of DNA Repair Genes";"Pausing and recovery of HIV elongation";"Formation of HIV elongation complex in the absence of HIV Tat"
XP_046434209.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046426941.1	3	KEGG: 00730+3.1.3.2;MetaCyc: PWY-6348;KEGG: 00740+3.1.3.2	"Thiamine metabolism";"Phosphate acquisition";"Riboflavin metabolism"
XP_046418477.1	1	Reactome: R-HSA-8854214	"TBC/RABGAPs"
XP_046416857.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_046423465.1	1	Reactome: R-HSA-201681	"TCF dependent signaling in response to WNT"
XP_046420711.1	14	MetaCyc: PWY-7035;MetaCyc: PWY-7036;MetaCyc: PWY-6598;MetaCyc: PWY-7602;MetaCyc: PWY-8041;MetaCyc: PWY-7601;KEGG: 00062+2.3.1.199;MetaCyc: PWY-5080;MetaCyc: PWY-7725;MetaCyc: PWY-7619;MetaCyc: PWY-5972;Reactome: R-HSA-75876;MetaCyc: PWY-7724;MetaCyc: PWY-6433	"(9Z)-tricosene biosynthesis";"Very long chain fatty acid biosynthesis II";"Sciadonate biosynthesis";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Ultra-long-chain fatty acid biosynthesis";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Fatty acid elongation";"Very long chain fatty acid biosynthesis I";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Juniperonate biosynthesis";"Stearate biosynthesis I (animals)";"Synthesis of very long-chain fatty acyl-CoAs";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Hydroxylated fatty acid biosynthesis (plants)"
XP_046424291.1	2	Reactome: R-HSA-2142691;Reactome: R-HSA-2142700	"Synthesis of Leukotrienes (LT) and Eoxins (EX)";"Synthesis of Lipoxins (LX)"
XP_046425275.1	1	Reactome: R-HSA-5689880	"Ub-specific processing proteases"
XP_046427313.1	7	KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1	"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Relaxin signaling pathway";"Thermogenesis";"Human cytomegalovirus infection";"mTOR signaling pathway";"PI3K-Akt signaling pathway"
XP_046431728.1	7	Reactome: R-HSA-5620922;Reactome: R-HSA-389960;Reactome: R-HSA-389957;Reactome: R-HSA-390450;Reactome: R-HSA-390471;Reactome: R-HSA-6798695;Reactome: R-HSA-6814122	"BBSome-mediated cargo-targeting to cilium";"Formation of tubulin folding intermediates by CCT/TriC";"Prefoldin mediated transfer of substrate to CCT/TriC";"Folding of actin by CCT/TriC";"Association of TriC/CCT with target proteins during biosynthesis";"Neutrophil degranulation";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"
XP_046423925.1	6	MetaCyc: PWY-7656;KEGG: 00073+1.2.1.84;Reactome: R-HSA-9640463;MetaCyc: PWY-6733;MetaCyc: PWY-5884;MetaCyc: PWY-7782	"Spodoptera littoralis pheromone biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax biosynthesis";"Sporopollenin precursors biosynthesis";"Wax esters biosynthesis I";"Plasmalogen biosynthesis"
XP_046423449.1	1	Reactome: R-HSA-9617828	"FOXO-mediated transcription of cell cycle genes"
XP_046435669.1	1	Reactome: R-HSA-611105	"Respiratory electron transport"
XP_046417910.1	10	MetaCyc: PWY-7344;MetaCyc: PWY-6527;MetaCyc: PWY-7328;MetaCyc: PWY-6317;MetaCyc: PWY-3821;MetaCyc: PWY-6397;Reactome: R-HSA-5609977;KEGG: 00520+5.1.3.2;KEGG: 00052+5.1.3.2;Reactome: R-HSA-70370	"UDP-alpha-D-galactose biosynthesis";"Stachyose degradation";"Superpathway of UDP-glucose-derived O-antigen building blocks biosynthesis";"D-galactose degradation I (Leloir pathway)";"D-galactose detoxification";"Mycolyl-arabinogalactan-peptidoglycan complex biosynthesis";"Defective GALE can cause Epimerase-deficiency galactosemia (EDG)";"Amino sugar and nucleotide sugar metabolism";"Galactose metabolism";"Galactose catabolism"
XP_046424379.1	2	Reactome: R-HSA-6814122;Reactome: R-HSA-418594	"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"G alpha (i) signalling events"
XP_046409358.1	9	MetaCyc: PWY-5743;MetaCyc: PWY-5744;MetaCyc: PWY-7117;MetaCyc: PWY-7115;Reactome: R-HSA-1475029;KEGG: 00910+4.2.1.1;MetaCyc: PWY-5789;MetaCyc: PWY-6142;MetaCyc: PWY-241	"3-hydroxypropanoate cycle";"Glyoxylate assimilation";"C4 photosynthetic carbon assimilation cycle, PEPCK type";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"Reversible hydration of carbon dioxide";"Nitrogen metabolism";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"C4 photosynthetic carbon assimilation cycle, NADP-ME type"
XP_046428184.1	3	Reactome: R-HSA-5578775;Reactome: R-HSA-425561;Reactome: R-HSA-418359	"Ion homeostasis";"Sodium/Calcium exchangers";"Reduction of cytosolic Ca++ levels"
XP_046416738.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_046425062.1	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
XP_046421695.1	3	Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-212436	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"Generic Transcription Pathway"
XP_046432094.1	7	KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1	"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Relaxin signaling pathway";"Thermogenesis";"Human cytomegalovirus infection"
XP_046418149.1	1	Reactome: R-HSA-1445148	"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
XP_046419128.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_046436703.1	3	MetaCyc: PWY-7894;Reactome: R-HSA-1650814;KEGG: 00330+1.14.11.2	"Procollagen hydroxylation and glycosylation";"Collagen biosynthesis and modifying enzymes";"Arginine and proline metabolism"
XP_046435326.1	2	Reactome: R-HSA-983168;Reactome: R-HSA-8951664	"Antigen processing: Ubiquitination & Proteasome degradation";"Neddylation"
XP_046418335.1	1	Reactome: R-HSA-611105	"Respiratory electron transport"
XP_046425083.1	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
XP_046433852.1	8	Reactome: R-HSA-8953750;Reactome: R-HSA-9609690;Reactome: R-HSA-8943724;Reactome: R-HSA-3214841;Reactome: R-HSA-212300;Reactome: R-HSA-4551638;Reactome: R-HSA-2559580;Reactome: R-HSA-5617472	"Transcriptional Regulation by E2F6";"HCMV Early Events";"Regulation of PTEN gene transcription";"PKMTs methylate histone lysines";"PRC2 methylates histones and DNA";"SUMOylation of chromatin organization proteins";"Oxidative Stress Induced Senescence";"Activation of anterior HOX genes in hindbrain development during early embryogenesis"
XP_046415713.1	2	Reactome: R-HSA-445095;Reactome: R-HSA-5576892	"Interaction between L1 and Ankyrins";"Phase 0 - rapid depolarisation"
XP_046422490.1	1	Reactome: R-HSA-2559584	"Formation of Senescence-Associated Heterochromatin Foci (SAHF)"
XP_046429270.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046427280.1	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
XP_046412653.1	4	Reactome: R-HSA-350054;Reactome: R-HSA-2894862;Reactome: R-HSA-2122947;Reactome: R-HSA-2644606	"Notch-HLH transcription pathway";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"NOTCH1 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 PEST Domain Mutants"
XP_046411567.1	1	Reactome: R-HSA-212436	"Generic Transcription Pathway"
XP_046411752.1	1	KEGG: 00480+3.4.11.2	"Glutathione metabolism"
XP_046418345.1	1	Reactome: R-HSA-9022692	"Regulation of MECP2 expression and activity"
XP_046427160.1	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
XP_046432571.1	1	Reactome: R-HSA-425986	"Sodium/Proton exchangers"
XP_046410444.1	6	MetaCyc: PWY-7391;Reactome: R-HSA-191273;KEGG: 00900+4.1.1.33;Reactome: R-HSA-446199;MetaCyc: PWY-922;Reactome: R-HSA-2426168	"Isoprene biosynthesis II (engineered)";"Cholesterol biosynthesis";"Terpenoid backbone biosynthesis";"Synthesis of Dolichyl-phosphate";"Mevalonate pathway I";"Activation of gene expression by SREBF (SREBP)"
XP_046420914.1	2	Reactome: R-HSA-3214841;Reactome: R-HSA-8936459	"PKMTs methylate histone lysines";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"
XP_046427988.1	3	Reactome: R-HSA-416482;Reactome: R-HSA-194840;Reactome: R-HSA-193648	"G alpha (12/13) signalling events";"Rho GTPase cycle";"NRAGE signals death through JNK"
XP_046424618.1	4	Reactome: R-HSA-167160;MetaCyc: PWY-7375;Reactome: R-HSA-77075;Reactome: R-HSA-72086	"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Mrna capping I";"RNA Pol II CTD phosphorylation and interaction with CE";"mRNA Capping"
XP_046409878.1	18	MetaCyc: PWY-7176;MetaCyc: PWY-7220;KEGG: 00983+2.7.4.6;MetaCyc: PWY-7205;MetaCyc: PWY-7197;MetaCyc: PWY-7227;MetaCyc: PWY-7224;MetaCyc: PWY-7226;MetaCyc: PWY-7187;Reactome: R-HSA-499943;MetaCyc: PWY-7184;MetaCyc: PWY-7210;MetaCyc: PWY-7221;MetaCyc: PWY-7222;MetaCyc: PWY-6545;KEGG: 00230+2.7.4.6;MetaCyc: PWY-7198;KEGG: 00240+2.7.4.6	"UTP and CTP de novo biosynthesis";"Adenosine deoxyribonucleotides de novo biosynthesis II";"Drug metabolism - other enzymes";"CMP phosphorylation";"Pyrimidine deoxyribonucleotide phosphorylation";"Adenosine deoxyribonucleotides de novo biosynthesis";"Purine deoxyribonucleosides salvage";"Guanosine deoxyribonucleotides de novo biosynthesis I";"Pyrimidine deoxyribonucleotides de novo biosynthesis II";"Interconversion of nucleotide di- and triphosphates";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Guanosine ribonucleotides de novo biosynthesis";"Guanosine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Purine metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Pyrimidine metabolism"
XP_046427363.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046435446.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046428779.1	2	Reactome: R-HSA-9010553;Reactome: R-HSA-975957	"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
XP_046435340.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_046431116.1	5	Reactome: R-HSA-450385;Reactome: R-HSA-430039;Reactome: R-HSA-450513;Reactome: R-HSA-450604;Reactome: R-HSA-380994	"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"mRNA decay by 5' to 3' exoribonuclease";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"KSRP (KHSRP) binds and destabilizes mRNA";"ATF4 activates genes in response to endoplasmic reticulum stress"
XP_046413334.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046429200.1	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286	"Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation"
XP_046422707.1	1	Reactome: R-HSA-425561	"Sodium/Calcium exchangers"
XP_046433105.1	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046415588.1	1	Reactome: R-HSA-162791	"Attachment of GPI anchor to uPAR"
XP_046434170.1	16	Reactome: R-HSA-72695;Reactome: R-HSA-1799339;Reactome: R-HSA-72689;Reactome: R-HSA-192823;Reactome: R-HSA-156902;Reactome: R-HSA-72649;Reactome: R-HSA-72764;Reactome: R-HSA-975957;Reactome: R-HSA-72706;Reactome: R-HSA-2408557;Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-72702;Reactome: R-HSA-975956;Reactome: R-HSA-6791226	"Formation of the ternary complex, and subsequently, the 43S complex";"SRP-dependent cotranslational protein targeting to membrane";"Formation of a pool of free 40S subunits";"Viral mRNA Translation";"Peptide chain elongation";"Translation initiation complex formation";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Selenocysteine synthesis";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Ribosomal scanning and start codon recognition";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046418023.1	13	Reactome: R-HSA-9633012;Reactome: R-HSA-72689;Reactome: R-HSA-192823;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-2408557;Reactome: R-HSA-72706;Reactome: R-HSA-1799339;Reactome: R-HSA-975957;Reactome: R-HSA-6791226;Reactome: R-HSA-975956;Reactome: R-HSA-156902;Reactome: R-HSA-72764	"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Formation of a pool of free 40S subunits";"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Selenocysteine synthesis";"GTP hydrolysis and joining of the 60S ribosomal subunit";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Peptide chain elongation";"Eukaryotic Translation Termination"
XP_046409822.1	2	KEGG: 00260+2.1.2.10;KEGG: 00670+2.1.2.10	"Glycine, serine and threonine metabolism";"One carbon pool by folate"
XP_046419635.1	2	KEGG: 00270+3.1.3.77;Reactome: R-HSA-1237112	"Cysteine and methionine metabolism";"Methionine salvage pathway"
XP_046423697.1	4	KEGG: 00510+2.4.1.260;Reactome: R-HSA-446193;Reactome: R-HSA-4720489;KEGG: 00513+2.4.1.260	"N-Glycan biosynthesis";"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"Defective ALG12 causes ALG12-CDG (CDG-1g)";"Various types of N-glycan biosynthesis"
XP_046422200.1	2	Reactome: R-HSA-8939243;Reactome: R-HSA-3214858	"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RMTs methylate histone arginines"
XP_046431247.1	3	Reactome: R-HSA-9609523;Reactome: R-HSA-1236974;Reactome: R-HSA-1799339	"Insertion of tail-anchored proteins into the endoplasmic reticulum membrane";"ER-Phagosome pathway";"SRP-dependent cotranslational protein targeting to membrane"
XP_046414343.1	13	Reactome: R-HSA-2871809;Reactome: R-HSA-2424491;Reactome: R-HSA-202433;KEGG: 00562+3.1.4.11;MetaCyc: PWY-6351;MetaCyc: PWY-7039;MetaCyc: PWY-6367;MetaCyc: PWY-8052;Reactome: R-HSA-2029485;Reactome: R-HSA-9027277;Reactome: R-HSA-2871796;Reactome: R-HSA-1855204;KEGG: 04070+3.1.4.11	"FCERI mediated Ca+2 mobilization";"DAP12 signaling";"Generation of second messenger molecules";"Inositol phosphate metabolism";"D-myo-inositol (1,4,5)-trisphosphate biosynthesis";"Phosphatidate metabolism, as a signaling molecule";"D-myo-inositol-5-phosphate metabolism";"2-arachidonoylglycerol biosynthesis";"Role of phospholipids in phagocytosis";"Erythropoietin activates Phospholipase C gamma (PLCG)";"FCERI mediated MAPK activation";"Synthesis of IP3 and IP4 in the cytosol";"Phosphatidylinositol signaling system"
XP_046411280.1	4	KEGG: 00970+6.1.1.6;Reactome: R-HSA-379716;Reactome: R-HSA-2408522;Reactome: R-HSA-379726	"Aminoacyl-tRNA biosynthesis";"Cytosolic tRNA aminoacylation";"Selenoamino acid metabolism";"Mitochondrial tRNA aminoacylation"
XP_046425844.1	1	Reactome: R-HSA-71064	"Lysine catabolism"
XP_046433577.1	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
XP_046427995.1	3	Reactome: R-HSA-194840;Reactome: R-HSA-416482;Reactome: R-HSA-193648	"Rho GTPase cycle";"G alpha (12/13) signalling events";"NRAGE signals death through JNK"
XP_046427423.1	9	KEGG: 04714+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05163+2.7.11.1;Reactome: R-HSA-6804756;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;Reactome: R-HSA-6782315;KEGG: 04151+2.7.11.1	"Thermogenesis";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Human cytomegalovirus infection";"Regulation of TP53 Activity through Phosphorylation";"Relaxin signaling pathway";"mTOR signaling pathway";"tRNA modification in the nucleus and cytosol";"PI3K-Akt signaling pathway"
XP_046426583.1	2	KEGG: 00270+3.3.1.1;MetaCyc: PWY-5041	"Cysteine and methionine metabolism";"S-adenosyl-L-methionine cycle II"
XP_046431381.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046427034.1	3	KEGG: 00790+3.1.3.1;MetaCyc: PWY-5491;KEGG: 00730+3.1.3.1	"Folate biosynthesis";"Diethylphosphate degradation";"Thiamine metabolism"
XP_046420987.1	1	Reactome: R-HSA-4551638	"SUMOylation of chromatin organization proteins"
XP_046421983.1	2	Reactome: R-HSA-1296052;Reactome: R-HSA-418457	"Ca2+ activated K+ channels";"cGMP effects"
XP_046415803.1	2	Reactome: R-HSA-5689896;Reactome: R-HSA-5689880	"Ovarian tumor domain proteases";"Ub-specific processing proteases"
XP_046429139.1	15	Reactome: R-HSA-1266695;Reactome: R-HSA-912526;Reactome: R-HSA-1433557;Reactome: R-HSA-2219530;Reactome: R-HSA-512988;Reactome: R-HSA-1257604;Reactome: R-HSA-388841;Reactome: R-HSA-389357;Reactome: R-HSA-416476;Reactome: R-HSA-912631;Reactome: R-HSA-8853659;Reactome: R-HSA-1660499;Reactome: R-HSA-9009391;Reactome: R-HSA-6811558;Reactome: R-HSA-114604	"Interleukin-7 signaling";"Interleukin receptor SHC signaling";"Signaling by SCF-KIT";"Constitutive Signaling by Aberrant PI3K in Cancer";"Interleukin-3, Interleukin-5 and GM-CSF signaling";"PIP3 activates AKT signaling";"Costimulation by the CD28 family";"CD28 dependent PI3K/Akt signaling";"G alpha (q) signalling events";"Regulation of signaling by CBL";"RET signaling";"Synthesis of PIPs at the plasma membrane";"Extra-nuclear estrogen signaling";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"GPVI-mediated activation cascade"
XP_046433519.1	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
XP_046409805.1	1	Reactome: R-HSA-425381	"Bicarbonate transporters"
XP_046416986.1	2	Reactome: R-HSA-6811438;Reactome: R-HSA-6811440	"Intra-Golgi traffic";"Retrograde transport at the Trans-Golgi-Network"
XP_046413770.1	1	KEGG: 00270+2.1.1.37	"Cysteine and methionine metabolism"
XP_046430848.1	4	MetaCyc: PWY-7221;Reactome: R-HSA-2161541;KEGG: 00230+2.7.4.8;Reactome: R-HSA-499943	"Guanosine ribonucleotides de novo biosynthesis";"Abacavir metabolism";"Purine metabolism";"Interconversion of nucleotide di- and triphosphates"
XP_046426367.1	3	MetaCyc: PWY-7159;Reactome: R-HSA-189451;KEGG: 00860+1.3.3.3	"3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent)";"Heme biosynthesis";"Porphyrin and chlorophyll metabolism"
XP_046435703.1	1	Reactome: R-HSA-1237044	"Erythrocytes take up carbon dioxide and release oxygen"
XP_046411750.1	1	KEGG: 00480+3.4.11.2	"Glutathione metabolism"
XP_046432047.1	1	Reactome: R-HSA-83936	"Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"
XP_046423998.1	1	Reactome: R-HSA-6794361	"Neurexins and neuroligins"
XP_046433282.1	52	Reactome: R-HSA-5578749;Reactome: R-HSA-73762;Reactome: R-HSA-167287;Reactome: R-HSA-6781827;Reactome: R-HSA-167158;Reactome: R-HSA-203927;Reactome: R-HSA-113418;Reactome: R-HSA-6782210;Reactome: R-HSA-6781823;Reactome: R-HSA-6807505;Reactome: R-HSA-167162;Reactome: R-HSA-8851708;Reactome: R-HSA-167161;Reactome: R-HSA-9018519;Reactome: R-HSA-168325;Reactome: R-HSA-72086;Reactome: R-HSA-73776;Reactome: R-HSA-167243;Reactome: R-HSA-72163;Reactome: R-HSA-73780;Reactome: R-HSA-112382;Reactome: R-HSA-75955;Reactome: R-HSA-5617472;Reactome: R-HSA-76042;Reactome: R-HSA-72203;Reactome: R-HSA-5250924;Reactome: R-HSA-167160;Reactome: R-HSA-73779;Reactome: R-HSA-6782135;Reactome: R-HSA-167238;Reactome: R-HSA-73980;Reactome: R-HSA-76066;Reactome: R-HSA-167246;Reactome: R-HSA-72165;Reactome: R-HSA-427413;Reactome: R-HSA-75953;Reactome: R-HSA-167152;Reactome: R-HSA-6803529;Reactome: R-HSA-1834949;Reactome: R-HSA-749476;Reactome: R-HSA-73772;Reactome: R-HSA-167290;Reactome: R-HSA-76061;Reactome: R-HSA-167200;Reactome: R-HSA-6796648;Reactome: R-HSA-77075;Reactome: R-HSA-674695;Reactome: R-HSA-167242;Reactome: R-HSA-76071;Reactome: R-HSA-5601884;Reactome: R-HSA-73863;Reactome: R-HSA-167172	"Transcriptional regulation by small RNAs";"RNA Polymerase I Transcription Initiation";"HIV elongation arrest and recovery";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Formation of the HIV-1 Early Elongation Complex";"MicroRNA (miRNA) biogenesis";"Formation of the Early Elongation Complex";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Formation of TC-NER Pre-Incision Complex";"RNA polymerase II transcribes snRNA genes";"RNA Polymerase II HIV Promoter Escape";"Signaling by FGFR2 IIIa TM";"HIV Transcription Initiation";"Estrogen-dependent gene expression";"Viral Messenger RNA Synthesis";"mRNA Capping";"RNA Polymerase II Promoter Escape";"Tat-mediated HIV elongation arrest and recovery";"mRNA Splicing - Major Pathway";"RNA Polymerase III Chain Elongation";"Formation of RNA Pol II elongation complex";"RNA Polymerase II Transcription Elongation";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Processing of Capped Intron-Containing Pre-mRNA";"B-WICH complex positively regulates rRNA expression";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Dual incision in TC-NER";"Pausing and recovery of Tat-mediated HIV elongation";"RNA Polymerase III Transcription Termination";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"Tat-mediated elongation of the HIV-1 transcript";"mRNA Splicing - Minor Pathway";"NoRC negatively regulates rRNA expression";"RNA Polymerase II Transcription Initiation";"Formation of HIV elongation complex in the absence of HIV Tat";"FGFR2 alternative splicing";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase I Promoter Escape";"Pausing and recovery of HIV elongation";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Pol II CTD phosphorylation and interaction with CE";"RNA Polymerase II Pre-transcription Events";"Abortive elongation of HIV-1 transcript in the absence of Tat";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"PIWI-interacting RNA (piRNA) biogenesis";"RNA Polymerase I Transcription Termination";"Transcription of the HIV genome"
XP_046419926.1	8	Reactome: R-HSA-5083633;MetaCyc: PWY-7979;KEGG: 00515+2.4.1.109;KEGG: 00514+2.4.1.109;MetaCyc: PWY-7921;MetaCyc: PWY-7922;Reactome: R-HSA-5083629;Reactome: R-HSA-5173105	"Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1";"Protein O-mannosylation III (mammals, core M3)";"Mannose type O-glycan biosynthesis";"Other types of O-glycan biosynthesis";"Protein O-mannosylation I (yeast)";"Protein O-mannosylation II (mammals, core M1 and core M2)";"Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2";"O-linked glycosylation"
XP_046413384.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046414195.1	2	Reactome: R-HSA-373080;Reactome: R-HSA-3238698	"Class B/2 (Secretin family receptors)";"WNT ligand biogenesis and trafficking"
XP_046429272.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046435330.1	1	MetaCyc: PWY-7437	"Protein O-[N-acetyl]-glucosylation"
XP_046417140.1	2	Reactome: R-HSA-70350;Reactome: R-HSA-168928	"Fructose catabolism";"DDX58/IFIH1-mediated induction of interferon-alpha/beta"
XP_046416884.1	13	KEGG: 00480+1.17.4.1;KEGG: 00230+1.17.4.1;MetaCyc: PWY-7227;MetaCyc: PWY-7198;MetaCyc: PWY-7226;MetaCyc: PWY-7220;KEGG: 00983+1.17.4.1;MetaCyc: PWY-7222;MetaCyc: PWY-6545;KEGG: 00240+1.17.4.1;Reactome: R-HSA-499943;MetaCyc: PWY-7184;MetaCyc: PWY-7210	"Glutathione metabolism";"Purine metabolism";"Adenosine deoxyribonucleotides de novo biosynthesis";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Guanosine deoxyribonucleotides de novo biosynthesis I";"Adenosine deoxyribonucleotides de novo biosynthesis II";"Drug metabolism - other enzymes";"Guanosine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Pyrimidine metabolism";"Interconversion of nucleotide di- and triphosphates";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Pyrimidine deoxyribonucleotides biosynthesis from CTP"
XP_046424140.1	6	Reactome: R-HSA-418592;Reactome: R-HSA-399997;Reactome: R-HSA-434316;Reactome: R-HSA-456926;Reactome: R-HSA-416476;Reactome: R-HSA-428930	"ADP signalling through P2Y purinoceptor 1";"Acetylcholine regulates insulin secretion";"Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion";"Thrombin signalling through proteinase activated receptors (PARs)";"G alpha (q) signalling events";"Thromboxane signalling through TP receptor"
XP_046414545.1	1	Reactome: R-HSA-5617833	"Cilium Assembly"
XP_046422516.1	6	Reactome: R-HSA-2500257;Reactome: R-HSA-5663220;Reactome: R-HSA-141444;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813;Reactome: R-HSA-68877	"Resolution of Sister Chromatid Cohesion";"RHO GTPases Activate Formins";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids";"Mitotic Prometaphase"
XP_046426501.1	7	KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1	"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Human cytomegalovirus infection";"Thermogenesis";"Relaxin signaling pathway";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection"
XP_046419531.1	2	Reactome: R-HSA-6791226;Reactome: R-HSA-8849473	"Major pathway of rRNA processing in the nucleolus and cytosol";"PTK6 Expression"
XP_046419809.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046414891.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_046415452.1	31	MetaCyc: PWY-6113;MetaCyc: PWY-5994;Reactome: R-HSA-163765;MetaCyc: PWY-5971;MetaCyc: PWY-6519;MetaCyc: PWY-7663;MetaCyc: PWY-5366;MetaCyc: PWY-6282;Reactome: R-HSA-75105;KEGG: 00061+1.1.1.100+2.3.1.85+4.2.1.59+2.3.1.39+2.3.1.41+3.1.2.14;MetaCyc: PWY-5973;MetaCyc: PWY-8047;MetaCyc: PWY-5147;MetaCyc: PWY-7746;MetaCyc: PWY-5989;MetaCyc: PWY-7723;MetaCyc: PWY-7858;Reactome: R-HSA-9029558;Reactome: R-HSA-2426168;Reactome: R-HSA-199220;MetaCyc: PWYG-321;MetaCyc: PWY-8049;MetaCyc: PWY-8012;MetaCyc: PWY-5367;KEGG: 00780+1.1.1.100+4.2.1.59+2.3.1.41;MetaCyc: PWY-7664;MetaCyc: PWY-5142;MetaCyc: PWY-5966-1;MetaCyc: PWY-7388;MetaCyc: PWY-4381;MetaCyc: PWY-6799	"Superpathway of mycolate biosynthesis";"Palmitate biosynthesis (animals and fungi, cytoplasm)";"ChREBP activates metabolic gene expression";"Palmitate biosynthesis II (bacteria and plant cytoplasm)";"8-amino-7-oxononanoate biosynthesis I";"Gondoate biosynthesis (anaerobic)";"Palmitoleate biosynthesis II (plants and bacteria)";"Palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate)";"Fatty acyl-CoA biosynthesis";"Fatty acid biosynthesis";"Cis-vaccenate biosynthesis";"Bryostatin biosynthesis";"Oleate biosynthesis I (plants)";"Mycobacterial sulfolipid biosynthesis";"Stearate biosynthesis II (bacteria and plants)";"Bacterial bioluminescence";"(5Z)-dodecenoate biosynthesis II";"NR1H2 & NR1H3 regulate gene expression linked to lipogenesis";"Activation of gene expression by SREBF (SREBP)";"Vitamin B5 (pantothenate) metabolism";"";"Pederin biosynthesis";"Mupirocin biosynthesis";"Petroselinate biosynthesis";"Biotin metabolism";"Oleate biosynthesis IV (anaerobic)";"Acyl-[acyl-carrier protein] thioesterase pathway";"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)";"Octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast)";"Fatty acid biosynthesis initiation (bacteria and plants)";"Fatty acid biosynthesis initiation (plant mitochondria)"
XP_046417896.1	5	MetaCyc: PWY-8043;Reactome: R-HSA-174403;KEGG: 00270+6.3.2.3;Reactome: R-HSA-5579006;KEGG: 00480+6.3.2.3	"Ophthalmate biosynthesis";"Glutathione synthesis and recycling";"Cysteine and methionine metabolism";"Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)";"Glutathione metabolism"
XP_046422823.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046435673.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
XP_046419412.1	7	Reactome: R-HSA-77111;Reactome: R-HSA-9033241;MetaCyc: PWY-5074;KEGG: 00072+4.1.3.4;KEGG: 00281+4.1.3.4;KEGG: 00280+4.1.3.4;KEGG: 00650+4.1.3.4	"Synthesis of Ketone Bodies";"Peroxisomal protein import";"Mevalonate degradation";"Synthesis and degradation of ketone bodies";"Geraniol degradation";"Valine, leucine and isoleucine degradation";"Butanoate metabolism"
XP_046423691.1	1	KEGG: 00970+6.1.1.7	"Aminoacyl-tRNA biosynthesis"
XP_046412644.1	4	Reactome: R-HSA-2644606;Reactome: R-HSA-2894862;Reactome: R-HSA-2122947;Reactome: R-HSA-350054	"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"NOTCH1 Intracellular Domain Regulates Transcription";"Notch-HLH transcription pathway"
XP_046430583.1	1	Reactome: R-HSA-426117	"Cation-coupled Chloride cotransporters"
XP_046432452.1	5	Reactome: R-HSA-6807004;Reactome: R-HSA-8856828;Reactome: R-HSA-8875360;Reactome: R-HSA-8856825;Reactome: R-HSA-182971	"Negative regulation of MET activity";"Clathrin-mediated endocytosis";"InlB-mediated entry of Listeria monocytogenes into host cell";"Cargo recognition for clathrin-mediated endocytosis";"EGFR downregulation"
XP_046428970.1	2	Reactome: R-HSA-1660499;Reactome: R-HSA-1632852	"Synthesis of PIPs at the plasma membrane";"Macroautophagy"
XP_046426626.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_046415648.1	3	KEGG: 00310+1.14.11.8;MetaCyc: PWY-6100;Reactome: R-HSA-71262	"Lysine degradation";"L-carnitine biosynthesis";"Carnitine synthesis"
XP_046416550.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046422005.1	5	Reactome: R-HSA-201722;Reactome: R-HSA-3214841;Reactome: R-HSA-8936459;Reactome: R-HSA-5617472;Reactome: R-HSA-3769402	"Formation of the beta-catenin:TCF transactivating complex";"PKMTs methylate histone lysines";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Deactivation of the beta-catenin transactivating complex"
XP_046414120.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_046436203.1	10	Reactome: R-HSA-611105;Reactome: R-HSA-111458;Reactome: R-HSA-5628897;Reactome: R-HSA-111464;Reactome: R-HSA-111463;Reactome: R-HSA-2151201;Reactome: R-HSA-9627069;Reactome: R-HSA-111459;Reactome: R-HSA-111457;Reactome: R-HSA-3299685	"Respiratory electron transport";"Formation of apoptosome";"TP53 Regulates Metabolic Genes";"SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes";"SMAC (DIABLO) binds to IAPs";"Transcriptional activation of mitochondrial biogenesis";"Regulation of the apoptosome activity";"Activation of caspases through apoptosome-mediated cleavage";"Release of apoptotic factors from the mitochondria";"Detoxification of Reactive Oxygen Species"
XP_046415854.1	7	KEGG: 00670+1.5.1.3;KEGG: 00790+1.5.1.3;Reactome: R-HSA-1474151;MetaCyc: PWY-6614;MetaCyc: PWY-3841;Reactome: R-HSA-196757;Reactome: R-HSA-69205	"One carbon pool by folate";"Folate biosynthesis";"Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation";"Tetrahydrofolate biosynthesis";"Folate transformations II (plants)";"Metabolism of folate and pterines";"G1/S-Specific Transcription"
XP_046413931.1	4	Reactome: R-HSA-6781823;Reactome: R-HSA-8951664;Reactome: R-HSA-5696394;Reactome: R-HSA-8856825	"Formation of TC-NER Pre-Incision Complex";"Neddylation";"DNA Damage Recognition in GG-NER";"Cargo recognition for clathrin-mediated endocytosis"
XP_046410849.1	3	Reactome: R-HSA-749476;Reactome: R-HSA-76061;Reactome: R-HSA-76066	"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Transcription Initiation From Type 2 Promoter"
XP_046431888.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046430006.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046416331.1	2	MetaCyc: PWY-6788;KEGG: 00500+3.2.1.4	"Cellulose degradation II (fungi)";"Starch and sucrose metabolism"
XP_046423372.1	6	MetaCyc: PWY-6348;Reactome: R-HSA-6807505;KEGG: 00740+3.1.3.2;KEGG: 00730+3.1.3.2;Reactome: R-HSA-76071;Reactome: R-HSA-749476	"Phosphate acquisition";"RNA polymerase II transcribes snRNA genes";"Riboflavin metabolism";"Thiamine metabolism";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Abortive And Retractive Initiation"
XP_046432805.1	4	Reactome: R-HSA-73856;Reactome: R-HSA-72163;Reactome: R-HSA-72187;Reactome: R-HSA-159236	"RNA Polymerase II Transcription Termination";"mRNA Splicing - Major Pathway";"mRNA 3'-end processing";"Transport of Mature mRNA derived from an Intron-Containing Transcript"
XP_046428786.1	1	Reactome: R-HSA-977225	"Amyloid fiber formation"
XP_046417758.1	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
XP_046424046.1	14	Reactome: R-HSA-6782210;Reactome: R-HSA-5655862;Reactome: R-HSA-110314;Reactome: R-HSA-5696397;Reactome: R-HSA-5656121;Reactome: R-HSA-5685942;Reactome: R-HSA-69091;Reactome: R-HSA-5651801;Reactome: R-HSA-174411;Reactome: R-HSA-110312;Reactome: R-HSA-5656169;Reactome: R-HSA-5696400;Reactome: R-HSA-110320;Reactome: R-HSA-6782135	"Gap-filling DNA repair synthesis and ligation in TC-NER";"Translesion synthesis by POLK";"Recognition of DNA damage by PCNA-containing replication complex";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Translesion synthesis by POLI";"HDR through Homologous Recombination (HRR)";"Polymerase switching";"PCNA-Dependent Long Patch Base Excision Repair";"Polymerase switching on the C-strand of the telomere";"Translesion synthesis by REV1";"Termination of translesion DNA synthesis";"Dual Incision in GG-NER";"Translesion Synthesis by POLH";"Dual incision in TC-NER"
XP_046423002.1	1	Reactome: R-HSA-429947	"Deadenylation of mRNA"
XP_046411681.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_046426004.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-8866654	"Protein ubiquitination";"E3 ubiquitin ligases ubiquitinate target proteins"
XP_046430047.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046427210.1	5	Reactome: R-HSA-6804758;Reactome: R-HSA-73762;Reactome: R-HSA-427389;Reactome: R-HSA-8943724;Reactome: R-HSA-3214815	"Regulation of TP53 Activity through Acetylation";"RNA Polymerase I Transcription Initiation";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"Regulation of PTEN gene transcription";"HDACs deacetylate histones"
XP_046415765.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046435781.1	12	Reactome: R-HSA-381038;Reactome: R-HSA-2132295;Reactome: R-HSA-380284;Reactome: R-HSA-380320;Reactome: R-HSA-2565942;Reactome: R-HSA-6811436;Reactome: R-HSA-380259;Reactome: R-HSA-5620912;Reactome: R-HSA-3371497;Reactome: R-HSA-380270;Reactome: R-HSA-8854518;Reactome: R-HSA-6807878	"XBP1(S) activates chaperone genes";"MHC class II antigen presentation";"Loss of proteins required for interphase microtubule organization from the centrosome";"Recruitment of NuMA to mitotic centrosomes";"Regulation of PLK1 Activity at G2/M Transition";"COPI-independent Golgi-to-ER retrograde traffic";"Loss of Nlp from mitotic centrosomes";"Anchoring of the basal body to the plasma membrane";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Recruitment of mitotic centrosome proteins and complexes";"AURKA Activation by TPX2";"COPI-mediated anterograde transport"
XP_046410599.1	1	Reactome: R-HSA-6799198	"Complex I biogenesis"
XP_046417832.1	4	Reactome: R-HSA-196757;KEGG: 00970+2.1.2.9;KEGG: 00670+2.1.2.9;KEGG: 00670+1.5.1.6	"Metabolism of folate and pterines";"Aminoacyl-tRNA biosynthesis";"One carbon pool by folate";"One carbon pool by folate"
XP_046427196.1	1	Reactome: R-HSA-1632852	"Macroautophagy"
XP_046436119.1	2	Reactome: R-HSA-163210;Reactome: R-HSA-8949613	"Formation of ATP by chemiosmotic coupling";"Cristae formation"
XP_046428967.1	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
XP_046420503.1	1	Reactome: R-HSA-428359	"Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA"
XP_046416524.1	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
XP_046416835.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
XP_046411083.1	3	Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-9018519	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"Estrogen-dependent gene expression"
XP_046412068.1	1	Reactome: R-HSA-977347	"Serine biosynthesis"
XP_046424142.1	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
XP_046410382.1	7	KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1	"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Relaxin signaling pathway";"Thermogenesis";"Human cytomegalovirus infection";"mTOR signaling pathway";"PI3K-Akt signaling pathway"
XP_046415072.1	3	Reactome: R-HSA-933542;Reactome: R-HSA-1810476;Reactome: R-HSA-445989	"TRAF6 mediated NF-kB activation";"RIP-mediated NFkB activation via ZBP1";"TAK1 activates NFkB by phosphorylation and activation of IKKs complex"
XP_046422668.1	1	Reactome: R-HSA-2132295	"MHC class II antigen presentation"
XP_046423994.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046421610.1	3	KEGG: 04070+2.7.4.24+2.7.4.21;Reactome: R-HSA-1855167;MetaCyc: PWY-6369	"Phosphatidylinositol signaling system";"Synthesis of pyrophosphates in the cytosol";"Inositol diphosphates biosynthesis"
XP_046412554.1	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
XP_046411073.1	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
XP_046416080.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-5628897	"Respiratory electron transport";"TP53 Regulates Metabolic Genes"
XP_046429587.1	7	KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1	"Relaxin signaling pathway";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Human cytomegalovirus infection";"Thermogenesis";"PI3K-Akt signaling pathway";"mTOR signaling pathway"
XP_046413279.1	16	Reactome: R-HSA-9018519;Reactome: R-HSA-8936459;Reactome: R-HSA-8943723;Reactome: R-HSA-1912408;Reactome: R-HSA-8986944;Reactome: R-HSA-2559585;Reactome: R-HSA-8948700;Reactome: R-HSA-5628897;Reactome: R-HSA-8934593;Reactome: R-HSA-4086398;Reactome: R-HSA-9022692;Reactome: R-HSA-8853884;Reactome: R-HSA-5687128;Reactome: R-HSA-9029569;Reactome: R-HSA-426496;Reactome: R-HSA-2559580	"Estrogen-dependent gene expression";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Regulation of PTEN mRNA translation";"Pre-NOTCH Transcription and Translation";"Transcriptional Regulation by MECP2";"Oncogene Induced Senescence";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"TP53 Regulates Metabolic Genes";"Regulation of RUNX1 Expression and Activity";"Ca2+ pathway";"Regulation of MECP2 expression and activity";"Transcriptional Regulation by VENTX";"MAPK6/MAPK4 signaling";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Post-transcriptional silencing by small RNAs";"Oxidative Stress Induced Senescence"
XP_046435306.1	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
XP_046431789.1	10	Reactome: R-HSA-202424;Reactome: R-HSA-983168;Reactome: R-HSA-5607761;Reactome: R-HSA-8951664;Reactome: R-HSA-2871837;Reactome: R-HSA-5684264;Reactome: R-HSA-2565942;Reactome: R-HSA-1169091;Reactome: R-HSA-5607764;Reactome: R-HSA-5676590	"Downstream TCR signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Dectin-1 mediated noncanonical NF-kB signaling";"Neddylation";"FCERI mediated NF-kB activation";"MAP3K8 (TPL2)-dependent MAPK1/3 activation";"Regulation of PLK1 Activity at G2/M Transition";"Activation of NF-kappaB in B cells";"CLEC7A (Dectin-1) signaling";"NIK-->noncanonical NF-kB signaling"
XP_046433913.1	1	Reactome: R-HSA-8876725	"Protein methylation"
XP_046409810.1	4	KEGG: 00514+2.4.1.255;Reactome: R-HSA-3214847;Reactome: R-HSA-5689603;MetaCyc: PWY-7437	"Other types of O-glycan biosynthesis";"HATs acetylate histones";"UCH proteinases";"Protein O-[N-acetyl]-glucosylation"
XP_046413590.1	1	Reactome: R-HSA-72165	"mRNA Splicing - Minor Pathway"
XP_046419254.1	7	Reactome: R-HSA-6814122;Reactome: R-HSA-6798695;Reactome: R-HSA-389957;Reactome: R-HSA-389960;Reactome: R-HSA-5620922;Reactome: R-HSA-390471;Reactome: R-HSA-390450	"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"Neutrophil degranulation";"Prefoldin mediated transfer of substrate to CCT/TriC";"Formation of tubulin folding intermediates by CCT/TriC";"BBSome-mediated cargo-targeting to cilium";"Association of TriC/CCT with target proteins during biosynthesis";"Folding of actin by CCT/TriC"
XP_046429941.1	3	Reactome: R-HSA-5083627;Reactome: R-HSA-5173105;Reactome: R-HSA-2022854	"Defective LARGE causes MDDGA6 and MDDGB6";"O-linked glycosylation";"Keratan sulfate biosynthesis"
XP_046417453.1	13	KEGG: 00983+1.17.4.1;MetaCyc: PWY-7220;MetaCyc: PWY-7198;MetaCyc: PWY-7227;MetaCyc: PWY-7226;KEGG: 00480+1.17.4.1;KEGG: 00230+1.17.4.1;MetaCyc: PWY-7184;MetaCyc: PWY-7210;Reactome: R-HSA-499943;MetaCyc: PWY-6545;KEGG: 00240+1.17.4.1;MetaCyc: PWY-7222	"Drug metabolism - other enzymes";"Adenosine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Adenosine deoxyribonucleotides de novo biosynthesis";"Guanosine deoxyribonucleotides de novo biosynthesis I";"Glutathione metabolism";"Purine metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Interconversion of nucleotide di- and triphosphates";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Pyrimidine metabolism";"Guanosine deoxyribonucleotides de novo biosynthesis II"
XP_046427527.1	1	Reactome: R-HSA-1971475	"A tetrasaccharide linker sequence is required for GAG synthesis"
XP_046418353.1	5	Reactome: R-HSA-6798695;Reactome: R-HSA-3134975;Reactome: R-HSA-3270619;Reactome: R-HSA-3249367;Reactome: R-HSA-1834941	"Neutrophil degranulation";"Regulation of innate immune responses to cytosolic DNA";"IRF3-mediated induction of type I IFN";"STAT6-mediated induction of chemokines";"STING mediated induction of host immune responses"
XP_046414158.1	10	MetaCyc: PWY-7909;MetaCyc: PWY-6613;KEGG: 00670+1.5.1.5+3.5.4.9;Reactome: R-HSA-196757;MetaCyc: PWY-5030;MetaCyc: PWY-2201;KEGG: 00720+1.5.1.5+3.5.4.9;MetaCyc: PWY-3841;MetaCyc: PWY-5497;MetaCyc: PWY-1722	"Formaldehyde oxidation VII (THF pathway)";"Tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate";"One carbon pool by folate";"Metabolism of folate and pterines";"L-histidine degradation III";"Folate transformations I";"Carbon fixation pathways in prokaryotes";"Folate transformations II (plants)";"Purine nucleobases degradation II (anaerobic)";"Formate assimilation into 5,10-methylenetetrahydrofolate"
XP_046434630.1	2	Reactome: R-HSA-6798695;Reactome: R-HSA-1799339	"Neutrophil degranulation";"SRP-dependent cotranslational protein targeting to membrane"
XP_046421904.1	6	KEGG: 00520+5.4.2.10;MetaCyc: PWY-6749;MetaCyc: PWY-6906;MetaCyc: PWY-5514;KEGG: 00520+5.4.2.3;Reactome: R-HSA-446210	"Amino sugar and nucleotide sugar metabolism";"CMP-legionaminate biosynthesis I";"Chitin derivatives degradation";"UDP-N-acetyl-D-galactosamine biosynthesis II";"Amino sugar and nucleotide sugar metabolism";"Synthesis of UDP-N-acetyl-glucosamine"
XP_046420471.1	1	Reactome: R-HSA-2151201	"Transcriptional activation of mitochondrial biogenesis"
XP_046417963.1	1	Reactome: R-HSA-428890	"Role of ABL in ROBO-SLIT signaling"
XP_046429736.1	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276	"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination"
XP_046414592.1	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
XP_046430724.1	5	Reactome: R-HSA-2132295;Reactome: R-HSA-6798695;Reactome: R-HSA-3371497;Reactome: R-HSA-6807878;Reactome: R-HSA-6811436	"MHC class II antigen presentation";"Neutrophil degranulation";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-mediated anterograde transport";"COPI-independent Golgi-to-ER retrograde traffic"
XP_046412995.1	27	Reactome: R-HSA-159227;Reactome: R-HSA-168333;Reactome: R-HSA-168271;Reactome: R-HSA-4615885;Reactome: R-HSA-159230;Reactome: R-HSA-5578749;Reactome: R-HSA-180746;Reactome: R-HSA-191859;Reactome: R-HSA-168276;Reactome: R-HSA-5619107;Reactome: R-HSA-3301854;Reactome: R-HSA-4551638;Reactome: R-HSA-4085377;Reactome: R-HSA-165054;Reactome: R-HSA-6784531;Reactome: R-HSA-180910;Reactome: R-HSA-3371453;Reactome: R-HSA-170822;Reactome: R-HSA-3232142;Reactome: R-HSA-9609690;Reactome: R-HSA-1169408;Reactome: R-HSA-3108214;Reactome: R-HSA-168325;Reactome: R-HSA-159231;Reactome: R-HSA-159236;Reactome: R-HSA-4570464;Reactome: R-HSA-9610379	"Transport of the SLBP independent Mature mRNA";"NEP/NS2 Interacts with the Cellular Export Machinery";"Transport of Ribonucleoproteins into the Host Nucleus";"SUMOylation of DNA replication proteins";"Transport of the SLBP Dependant Mature mRNA";"Transcriptional regulation by small RNAs";"Nuclear import of Rev protein";"snRNP Assembly";"NS1 Mediated Effects on Host Pathways";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Nuclear Pore Complex (NPC) Disassembly";"SUMOylation of chromatin organization proteins";"SUMOylation of SUMOylation proteins";"Rev-mediated nuclear export of HIV RNA";"tRNA processing in the nucleus";"Vpr-mediated nuclear import of PICs";"Regulation of HSF1-mediated heat shock response";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"SUMOylation of ubiquitinylation proteins";"HCMV Early Events";"ISG15 antiviral mechanism";"SUMOylation of DNA damage response and repair proteins";"Viral Messenger RNA Synthesis";"Transport of Mature mRNA Derived from an Intronless Transcript";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"SUMOylation of RNA binding proteins";"HCMV Late Events"
XP_046412394.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_046430151.1	5	MetaCyc: PWY-6906;MetaCyc: PWY-5514;Reactome: R-HSA-70171;MetaCyc: PWY-6855;KEGG: 00520+3.5.99.6	"Chitin derivatives degradation";"UDP-N-acetyl-D-galactosamine biosynthesis II";"Glycolysis";"Chitin degradation I (archaea)";"Amino sugar and nucleotide sugar metabolism"
XP_046431434.1	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
XP_046418476.1	1	Reactome: R-HSA-8854214	"TBC/RABGAPs"
XP_046422003.1	2	Reactome: R-HSA-1296052;Reactome: R-HSA-418457	"Ca2+ activated K+ channels";"cGMP effects"
XP_046425364.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_046421667.1	3	Reactome: R-HSA-212436;Reactome: R-HSA-381340;Reactome: R-HSA-1989781	"Generic Transcription Pathway";"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression"
XP_046421246.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046413585.1	6	Reactome: R-HSA-6798695;Reactome: R-HSA-9615017;KEGG: 00380+1.11.1.6;KEGG: 00630+1.11.1.6;Reactome: R-HSA-9033241;Reactome: R-HSA-3299685	"Neutrophil degranulation";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"Tryptophan metabolism";"Glyoxylate and dicarboxylate metabolism";"Peroxisomal protein import";"Detoxification of Reactive Oxygen Species"
XP_046435560.1	6	Reactome: R-HSA-5632928;Reactome: R-HSA-6796648;Reactome: R-HSA-5358565;Reactome: R-HSA-5632968;Reactome: R-HSA-5358606;Reactome: R-HSA-5632927	"Defective Mismatch Repair Associated With MSH2";"TP53 Regulates Transcription of DNA Repair Genes";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"Defective Mismatch Repair Associated With MSH6";"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"Defective Mismatch Repair Associated With MSH3"
XP_046414964.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_046417239.1	7	Reactome: R-HSA-5663220;Reactome: R-HSA-2500257;Reactome: R-HSA-4615885;Reactome: R-HSA-68877;Reactome: R-HSA-2467813;Reactome: R-HSA-9648025;Reactome: R-HSA-141444	"RHO GTPases Activate Formins";"Resolution of Sister Chromatid Cohesion";"SUMOylation of DNA replication proteins";"Mitotic Prometaphase";"Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"
XP_046428891.1	20	MetaCyc: PWY-7574;MetaCyc: PWY-7337;MetaCyc: PWY-7288;MetaCyc: PWY-7340;MetaCyc: PWY-7606;MetaCyc: PWY-7726;MetaCyc: PWY-7007;MetaCyc: PWY-7854;Reactome: R-HSA-9033241;KEGG: 00410+1.3.3.6;MetaCyc: PWY-5136;KEGG: 00592+1.3.3.6;KEGG: 00640+1.3.3.6;MetaCyc: PWY-735;MetaCyc: PWY-6837;MetaCyc: PWY-7338;KEGG: 00071+1.3.3.6;MetaCyc: PWY-7291;MetaCyc: PWY-7858;MetaCyc: PWY-6920	"Propanoyl-coa degradation II";"10-cis-heptadecenoyl-CoA degradation (yeast)";"Fatty acid beta-oxidation VII (yeast peroxisome)";"9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast)";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"Methyl ketone biosynthesis (engineered)";"Crotonyl-coa/ethylmalonyl-coa/hydroxybutyryl-coa cycle (engineered)";"Peroxisomal protein import";"beta-Alanine metabolism";"Fatty acid beta-oxidation II (plant peroxisome)";"alpha-Linolenic acid metabolism";"Propanoate metabolism";"Jasmonic acid biosynthesis";"Fatty acid beta-oxidation V (unsaturated, odd number, di-isomerase-dependent)";"10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast)";"Fatty acid degradation";"Oleate beta-oxidation (isomerase-dependent, yeast)";"(5Z)-dodecenoate biosynthesis II";"6-gingerol analog biosynthesis (engineered)"
XP_046430093.1	3	Reactome: R-HSA-947581;MetaCyc: PWY-6823;KEGG: 00790+2.10.1.1	"Molybdenum cofactor biosynthesis";"Molybdenum cofactor biosynthesis";"Folate biosynthesis"
XP_046411754.1	1	KEGG: 00480+3.4.11.2	"Glutathione metabolism"
XP_046429870.1	7	Reactome: R-HSA-69656;Reactome: R-HSA-69202;Reactome: R-HSA-1538133;Reactome: R-HSA-69205;Reactome: R-HSA-1362277;Reactome: R-HSA-156711;Reactome: R-HSA-1362300	"Cyclin A:Cdk2-associated events at S phase entry";"Cyclin E associated events during G1/S transition";"G0 and Early G1";"G1/S-Specific Transcription";"Transcription of E2F targets under negative control by DREAM complex";"Polo-like kinase mediated events";"Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1"
XP_046423075.1	3	Reactome: R-HSA-1614603;Reactome: R-HSA-1614558;Reactome: R-HSA-2408508	"Cysteine formation from homocysteine";"Degradation of cysteine and homocysteine";"Metabolism of ingested SeMet, Sec, MeSec into H2Se"
XP_046412898.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_046428365.1	2	Reactome: R-HSA-5339700;Reactome: R-HSA-4641265	"TCF7L2 mutants don't bind CTBP";"Repression of WNT target genes"
XP_046411746.1	1	KEGG: 00480+3.4.11.2	"Glutathione metabolism"
XP_046432031.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_046422633.1	2	Reactome: R-HSA-5689603;Reactome: R-HSA-5696394	"UCH proteinases";"DNA Damage Recognition in GG-NER"
XP_046416478.1	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
XP_046425351.1	5	MetaCyc: PWY-7536;KEGG: 00860+2.3.1.37;Reactome: R-HSA-189451;KEGG: 00260+2.3.1.37;MetaCyc: PWY-5189	"2-amino-3-hydroxycyclopent-2-enone biosynthesis";"Porphyrin and chlorophyll metabolism";"Heme biosynthesis";"Glycine, serine and threonine metabolism";"Tetrapyrrole biosynthesis II (from glycine)"
XP_046423294.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_046430057.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_046430010.1	3	MetaCyc: PWY-6829;MetaCyc: PWY-7888;Reactome: R-HSA-6782315	"Trna methylation (yeast)";"Trna-uridine 2-thiolation (cytoplasmic)";"tRNA modification in the nucleus and cytosol"
XP_046428093.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_046426786.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_046424176.1	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
XP_046412650.1	4	Reactome: R-HSA-2122947;Reactome: R-HSA-2894862;Reactome: R-HSA-2644606;Reactome: R-HSA-350054	"NOTCH1 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Notch-HLH transcription pathway"
XP_046413943.1	1	Reactome: R-HSA-425381	"Bicarbonate transporters"
XP_046422662.1	4	Reactome: R-HSA-72163;Reactome: R-HSA-72187;Reactome: R-HSA-159236;Reactome: R-HSA-73856	"mRNA Splicing - Major Pathway";"mRNA 3'-end processing";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"RNA Polymerase II Transcription Termination"
XP_046428886.1	20	MetaCyc: PWY-6920;MetaCyc: PWY-7858;MetaCyc: PWY-7291;KEGG: 00071+1.3.3.6;MetaCyc: PWY-7338;MetaCyc: PWY-6837;MetaCyc: PWY-735;KEGG: 00592+1.3.3.6;KEGG: 00640+1.3.3.6;MetaCyc: PWY-5136;KEGG: 00410+1.3.3.6;Reactome: R-HSA-9033241;MetaCyc: PWY-7854;MetaCyc: PWY-7007;MetaCyc: PWY-7726;MetaCyc: PWY-7606;MetaCyc: PWY-7340;MetaCyc: PWY-7288;MetaCyc: PWY-7337;MetaCyc: PWY-7574	"6-gingerol analog biosynthesis (engineered)";"(5Z)-dodecenoate biosynthesis II";"Oleate beta-oxidation (isomerase-dependent, yeast)";"Fatty acid degradation";"10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast)";"Fatty acid beta-oxidation V (unsaturated, odd number, di-isomerase-dependent)";"Jasmonic acid biosynthesis";"alpha-Linolenic acid metabolism";"Propanoate metabolism";"Fatty acid beta-oxidation II (plant peroxisome)";"beta-Alanine metabolism";"Peroxisomal protein import";"Crotonyl-coa/ethylmalonyl-coa/hydroxybutyryl-coa cycle (engineered)";"Methyl ketone biosynthesis (engineered)";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast)";"Fatty acid beta-oxidation VII (yeast peroxisome)";"10-cis-heptadecenoyl-CoA degradation (yeast)";"Propanoyl-coa degradation II"
XP_046431081.1	4	Reactome: R-HSA-4641265;Reactome: R-HSA-2122947;Reactome: R-HSA-201722;Reactome: R-HSA-3769402	"Repression of WNT target genes";"NOTCH1 Intracellular Domain Regulates Transcription";"Formation of the beta-catenin:TCF transactivating complex";"Deactivation of the beta-catenin transactivating complex"
XP_046425125.1	1	Reactome: R-HSA-975957	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
XP_046426459.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_046415655.1	6	Reactome: R-HSA-6798695;Reactome: R-HSA-983712;Reactome: R-HSA-9639288;Reactome: R-HSA-917977;Reactome: R-HSA-77387;Reactome: R-HSA-1222556	"Neutrophil degranulation";"Ion channel transport";"Amino acids regulate mTORC1";"Transferrin endocytosis and recycling";"Insulin receptor recycling";"ROS and RNS production in phagocytes"
XP_046425446.1	2	Reactome: R-HSA-204626;MetaCyc: PWY-5905	"Hypusine synthesis from eIF5A-lysine";"Hypusine biosynthesis"
XP_046419566.1	7	MetaCyc: PWY-7511;Reactome: R-HSA-2691232;Reactome: R-HSA-2979096;Reactome: R-HSA-9013507;Reactome: R-HSA-2644606;Reactome: R-HSA-2122948;Reactome: R-HSA-2894862	"Protein ubiquitination";"Constitutive Signaling by NOTCH1 HD Domain Mutants";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Activated NOTCH1 Transmits Signal to the Nucleus";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants"
XP_046435047.1	57	Reactome: R-HSA-5607761;Reactome: R-HSA-5658442;Reactome: R-HSA-983168;Reactome: R-HSA-174154;Reactome: R-HSA-174184;Reactome: R-HSA-8939902;Reactome: R-HSA-2467813;Reactome: R-HSA-8951664;Reactome: R-HSA-5689880;Reactome: R-HSA-174084;Reactome: R-HSA-349425;Reactome: R-HSA-1236978;Reactome: R-HSA-4608870;Reactome: R-HSA-4641257;Reactome: R-HSA-202424;Reactome: R-HSA-75815;Reactome: R-HSA-180585;Reactome: R-HSA-5678895;Reactome: R-HSA-5610785;Reactome: R-HSA-8939236;Reactome: R-HSA-1236974;Reactome: R-HSA-532668;Reactome: R-HSA-450408;Reactome: R-HSA-5610780;Reactome: R-HSA-5632684;Reactome: R-HSA-4641258;Reactome: R-HSA-211733;Reactome: R-HSA-5668541;Reactome: R-HSA-350562;Reactome: R-HSA-9010553;Reactome: R-HSA-8941858;Reactome: R-HSA-5358346;Reactome: R-HSA-69017;Reactome: R-HSA-69601;Reactome: R-HSA-9604323;Reactome: R-HSA-5362768;Reactome: R-HSA-5676590;Reactome: R-HSA-382556;Reactome: R-HSA-1169091;Reactome: R-HSA-68949;Reactome: R-HSA-2871837;Reactome: R-HSA-174178;Reactome: R-HSA-195253;Reactome: R-HSA-8854050;Reactome: R-HSA-9020702;Reactome: R-HSA-174113;Reactome: R-HSA-5687128;Reactome: R-HSA-5689603;Reactome: R-HSA-68827;Reactome: R-HSA-5607764;Reactome: R-HSA-180534;Reactome: R-HSA-187577;Reactome: R-HSA-1234176;Reactome: R-HSA-8948751;Reactome: R-HSA-69481;Reactome: R-HSA-8852276;Reactome: R-HSA-5610783	"Dectin-1 mediated noncanonical NF-kB signaling";"Regulation of RAS by GAPs";"Antigen processing: Ubiquitination & Proteasome degradation";"APC/C:Cdc20 mediated degradation of Securin";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Regulation of RUNX2 expression and activity";"Separation of Sister Chromatids";"Neddylation";"Ub-specific processing proteases";"Autodegradation of Cdh1 by Cdh1:APC/C";"Autodegradation of the E3 ubiquitin ligase COP1";"Cross-presentation of soluble exogenous antigens (endosomes)";"Asymmetric localization of PCP proteins";"Degradation of AXIN";"Downstream TCR signaling";"Ubiquitin-dependent degradation of Cyclin D";"Vif-mediated degradation of APOBEC3G";"Defective CFTR causes cystic fibrosis";"GLI3 is processed to GLI3R by the proteasome";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"ER-Phagosome pathway";"N-glycan trimming in the ER and Calnexin/Calreticulin cycle";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Degradation of GLI1 by the proteasome";"Hedgehog 'on' state";"Degradation of DVL";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"TNFR2 non-canonical NF-kB pathway";"Regulation of ornithine decarboxylase (ODC)";"Regulation of expression of SLITs and ROBOs";"Regulation of RUNX3 expression and activity";"Hedgehog ligand biogenesis";"CDK-mediated phosphorylation and removal of Cdc6";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Negative regulation of NOTCH4 signaling";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"NIK-->noncanonical NF-kB signaling";"ABC-family proteins mediated transport";"Activation of NF-kappaB in B cells";"Orc1 removal from chromatin";"FCERI mediated NF-kB activation";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Degradation of beta-catenin by the destruction complex";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Interleukin-1 signaling";"SCF-beta-TrCP mediated degradation of Emi1";"MAPK6/MAPK4 signaling";"UCH proteinases";"CDT1 association with the CDC6:ORC:origin complex";"CLEC7A (Dectin-1) signaling";"Vpu mediated degradation of CD4";"SCF(Skp2)-mediated degradation of p27/p21";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of PTEN stability and activity";"G2/M Checkpoints";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Degradation of GLI2 by the proteasome"
XP_046424034.1	1	Reactome: R-HSA-2022928	"HS-GAG biosynthesis"
XP_046412913.1	4	Reactome: R-HSA-6807505;KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16	"RNA polymerase II transcribes snRNA genes";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation"
XP_046417039.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
XP_046431854.1	1	Reactome: R-HSA-2995383	"Initiation of Nuclear Envelope Reformation"
XP_046430615.1	3	Reactome: R-HSA-6798695;Reactome: R-HSA-6807004;Reactome: R-HSA-202427	"Neutrophil degranulation";"Negative regulation of MET activity";"Phosphorylation of CD3 and TCR zeta chains"
XP_046421258.1	4	MetaCyc: PWY-7219;KEGG: 00250+6.3.4.4;KEGG: 00230+6.3.4.4;Reactome: R-HSA-73817	"Adenosine ribonucleotides de novo biosynthesis";"Alanine, aspartate and glutamate metabolism";"Purine metabolism";"Purine ribonucleoside monophosphate biosynthesis"
XP_046422948.1	1	Reactome: R-HSA-375276	"Peptide ligand-binding receptors"
XP_046433683.1	4	Reactome: R-HSA-5696395;Reactome: R-HSA-6782135;Reactome: R-HSA-6781823;Reactome: R-HSA-5696400	"Formation of Incision Complex in GG-NER";"Dual incision in TC-NER";"Formation of TC-NER Pre-Incision Complex";"Dual Incision in GG-NER"
XP_046415231.1	12	MetaCyc: PWY-7221;Reactome: R-HSA-442982;Reactome: R-HSA-9609736;Reactome: R-HSA-399719;Reactome: R-HSA-8849932;Reactome: R-HSA-451308;Reactome: R-HSA-447038;Reactome: R-HSA-9617324;Reactome: R-HSA-438066;KEGG: 00230+2.7.4.8;Reactome: R-HSA-9620244;Reactome: R-HSA-5673001	"Guanosine ribonucleotides de novo biosynthesis";"Ras activation upon Ca2+ influx through NMDA receptor";"Assembly and cell surface presentation of NMDA receptors";"Trafficking of AMPA receptors";"Synaptic adhesion-like molecules";"Activation of Ca-permeable Kainate Receptor";"NrCAM interactions";"Negative regulation of NMDA receptor-mediated neuronal transmission";"Unblocking of NMDA receptors, glutamate binding and activation";"Purine metabolism";"Long-term potentiation";"RAF/MAP kinase cascade"
XP_046419374.1	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
XP_046432699.1	1	Reactome: R-HSA-381753	"Olfactory Signaling Pathway"
XP_046426742.1	3	Reactome: R-HSA-8951664;MetaCyc: PWY-7511;Reactome: R-HSA-349425	"Neddylation";"Protein ubiquitination";"Autodegradation of the E3 ubiquitin ligase COP1"
XP_046415101.1	4	KEGG: 00970+6.1.1.18;Reactome: R-HSA-2408522;Reactome: R-HSA-379726;Reactome: R-HSA-379716	"Aminoacyl-tRNA biosynthesis";"Selenoamino acid metabolism";"Mitochondrial tRNA aminoacylation";"Cytosolic tRNA aminoacylation"
XP_046426513.1	2	Reactome: R-HSA-5628897;Reactome: R-HSA-611105	"TP53 Regulates Metabolic Genes";"Respiratory electron transport"
XP_046427063.1	33	Reactome: R-HSA-167160;Reactome: R-HSA-8939236;Reactome: R-HSA-6782135;Reactome: R-HSA-73779;Reactome: R-HSA-69202;Reactome: R-HSA-75953;Reactome: R-HSA-69656;Reactome: R-HSA-427413;Reactome: R-HSA-167246;Reactome: R-HSA-73772;Reactome: R-HSA-167152;Reactome: R-HSA-5696395;Reactome: R-HSA-674695;Reactome: R-HSA-6796648;Reactome: R-HSA-167200;Reactome: R-HSA-77075;Reactome: R-HSA-73863;Reactome: R-HSA-69231;Reactome: R-HSA-167172;Reactome: R-HSA-73762;Reactome: R-HSA-167158;Reactome: R-HSA-6781827;Reactome: R-HSA-113418;Reactome: R-HSA-6782210;Reactome: R-HSA-69273;Reactome: R-HSA-167162;Reactome: R-HSA-6781823;Reactome: R-HSA-167161;Reactome: R-HSA-73776;Reactome: R-HSA-72086;Reactome: R-HSA-112382;Reactome: R-HSA-76042;Reactome: R-HSA-75955	"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Dual incision in TC-NER";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Cyclin E associated events during G1/S transition";"RNA Polymerase II Transcription Initiation";"Cyclin A:Cdk2-associated events at S phase entry";"NoRC negatively regulates rRNA expression";"Tat-mediated elongation of the HIV-1 transcript";"RNA Polymerase I Promoter Escape";"Formation of HIV elongation complex in the absence of HIV Tat";"Formation of Incision Complex in GG-NER";"RNA Polymerase II Pre-transcription Events";"TP53 Regulates Transcription of DNA Repair Genes";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Pol II CTD phosphorylation and interaction with CE";"RNA Polymerase I Transcription Termination";"Cyclin D associated events in G1";"Transcription of the HIV genome";"RNA Polymerase I Transcription Initiation";"Formation of the HIV-1 Early Elongation Complex";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Formation of the Early Elongation Complex";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Cyclin A/B1/B2 associated events during G2/M transition";"RNA Polymerase II HIV Promoter Escape";"Formation of TC-NER Pre-Incision Complex";"HIV Transcription Initiation";"RNA Polymerase II Promoter Escape";"mRNA Capping";"Formation of RNA Pol II elongation complex";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II Transcription Elongation"
XP_046421442.1	24	Reactome: R-HSA-418217;Reactome: R-HSA-163359;Reactome: R-HSA-9009391;Reactome: R-HSA-4086398;Reactome: R-HSA-8964616;Reactome: R-HSA-392170;Reactome: R-HSA-6814122;Reactome: R-HSA-418594;Reactome: R-HSA-202040;Reactome: R-HSA-392451;Reactome: R-HSA-456926;Reactome: R-HSA-418592;Reactome: R-HSA-416482;Reactome: R-HSA-392851;Reactome: R-HSA-400042;Reactome: R-HSA-418555;Reactome: R-HSA-500657;Reactome: R-HSA-418597;Reactome: R-HSA-416476;Reactome: R-HSA-432040;Reactome: R-HSA-8964315;Reactome: R-HSA-428930;Reactome: R-HSA-381676;Reactome: R-HSA-420092	"G beta:gamma signalling through PLC beta";"Glucagon signaling in metabolic regulation";"Extra-nuclear estrogen signaling";"Ca2+ pathway";"G beta:gamma signalling through CDC42";"ADP signalling through P2Y purinoceptor 12";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"G alpha (i) signalling events";"G-protein activation";"G beta:gamma signalling through PI3Kgamma";"Thrombin signalling through proteinase activated receptors (PARs)";"ADP signalling through P2Y purinoceptor 1";"G alpha (12/13) signalling events";"Prostacyclin signalling through prostacyclin receptor";"Adrenaline,noradrenaline inhibits insulin secretion";"G alpha (s) signalling events";"Presynaptic function of Kainate receptors";"G alpha (z) signalling events";"G alpha (q) signalling events";"Vasopressin regulates renal water homeostasis via Aquaporins";"G beta:gamma signalling through BTK";"Thromboxane signalling through TP receptor";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"Glucagon-type ligand receptors"
XP_046436414.1	5	Reactome: R-HSA-73621;Reactome: R-HSA-73614;KEGG: 00983+2.4.2.3;MetaCyc: PWY-5532;KEGG: 00240+2.4.2.3	"Pyrimidine catabolism";"Pyrimidine salvage";"Drug metabolism - other enzymes";"Nucleoside and nucleotide degradation (archaea)";"Pyrimidine metabolism"
XP_046413519.1	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
XP_046425310.1	3	Reactome: R-HSA-194840;Reactome: R-HSA-416482;Reactome: R-HSA-193648	"Rho GTPase cycle";"G alpha (12/13) signalling events";"NRAGE signals death through JNK"
XP_046423398.1	2	Reactome: R-HSA-162710;KEGG: 00563+2.4.1.198	"Synthesis of glycosylphosphatidylinositol (GPI)";"Glycosylphosphatidylinositol (GPI)-anchor biosynthesis"
XP_046434190.1	1	Reactome: R-HSA-1474228	"Degradation of the extracellular matrix"
XP_046423712.1	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
XP_046421745.1	3	Reactome: R-HSA-112382;Reactome: R-HSA-674695;Reactome: R-HSA-75955	"Formation of RNA Pol II elongation complex";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Transcription Elongation"
XP_046434717.1	19	Reactome: R-HSA-975634;Reactome: R-HSA-202733;Reactome: R-HSA-8964046;Reactome: R-HSA-3000471;Reactome: R-HSA-5686938;Reactome: R-HSA-8963888;Reactome: R-HSA-8866423;Reactome: R-HSA-3000497;Reactome: R-HSA-3000480;Reactome: R-HSA-8964041;Reactome: R-HSA-3000484;Reactome: R-HSA-381426;Reactome: R-HSA-8856828;Reactome: R-HSA-432142;Reactome: R-HSA-8963901;Reactome: R-HSA-8964026;Reactome: R-HSA-8964038;Reactome: R-HSA-8957275;Reactome: R-HSA-8856825	"Retinoid metabolism and transport";"Cell surface interactions at the vascular wall";"VLDL clearance";"Scavenging by Class B Receptors";"Regulation of TLR by endogenous ligand";"Chylomicron assembly";"VLDL assembly";"Scavenging by Class H Receptors";"Scavenging by Class A Receptors";"LDL remodeling";"Scavenging by Class F Receptors";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"Clathrin-mediated endocytosis";"Platelet sensitization by LDL";"Chylomicron remodeling";"Chylomicron clearance";"LDL clearance";"Post-translational protein phosphorylation";"Cargo recognition for clathrin-mediated endocytosis"
XP_046415708.1	10	Reactome: R-HSA-2514853;Reactome: R-HSA-6814122;Reactome: R-HSA-6804756;Reactome: R-HSA-8948751;Reactome: R-HSA-201688;Reactome: R-HSA-1483191;Reactome: R-HSA-6798695;Reactome: R-HSA-8939243;Reactome: R-HSA-8934903;Reactome: R-HSA-445144	"Condensation of Prometaphase Chromosomes";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"Regulation of TP53 Activity through Phosphorylation";"Regulation of PTEN stability and activity";"WNT mediated activation of DVL";"Synthesis of PC";"Neutrophil degranulation";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"Receptor Mediated Mitophagy";"Signal transduction by L1"
XP_046427513.1	3	KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16	"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
XP_046421383.1	3	MetaCyc: PWY-5129;KEGG: 00600+1.14.19.17;Reactome: R-HSA-1660661	"Sphingolipid biosynthesis (plants)";"Sphingolipid metabolism";"Sphingolipid de novo biosynthesis"
XP_046413490.1	11	Reactome: R-HSA-164378;Reactome: R-HSA-163359;Reactome: R-HSA-418555;Reactome: R-HSA-170660;Reactome: R-HSA-418597;Reactome: R-HSA-418594;Reactome: R-HSA-432040;Reactome: R-HSA-5610787;Reactome: R-HSA-163615;Reactome: R-HSA-170670;KEGG: 00230+4.6.1.1	"PKA activation in glucagon signalling";"Glucagon signaling in metabolic regulation";"G alpha (s) signalling events";"Adenylate cyclase activating pathway";"G alpha (z) signalling events";"G alpha (i) signalling events";"Vasopressin regulates renal water homeostasis via Aquaporins";"Hedgehog 'off' state";"PKA activation";"Adenylate cyclase inhibitory pathway";"Purine metabolism"
XP_046428650.1	1	Reactome: R-HSA-525793	"Myogenesis"
XP_046436251.1	2	Reactome: R-HSA-8949215;Reactome: R-HSA-8949664	"Mitochondrial calcium ion transport";"Processing of SMDT1"
XP_046426072.1	5	Reactome: R-HSA-4655427;Reactome: R-HSA-427413;Reactome: R-HSA-212300;Reactome: R-HSA-5334118;KEGG: 00270+2.1.1.37	"SUMOylation of DNA methylation proteins";"NoRC negatively regulates rRNA expression";"PRC2 methylates histones and DNA";"DNA methylation";"Cysteine and methionine metabolism"
XP_046432023.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_046412152.1	1	Reactome: R-HSA-6814848	"Glycerophospholipid catabolism"
XP_046422972.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-8866654	"Protein ubiquitination";"E3 ubiquitin ligases ubiquitinate target proteins"
XP_046423733.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_046429232.1	1	Reactome: R-HSA-389661	"Glyoxylate metabolism and glycine degradation"
XP_046427779.1	1	Reactome: R-HSA-9633012	"Response of EIF2AK4 (GCN2) to amino acid deficiency"
XP_046431958.1	1	Reactome: R-HSA-5669034	"TNFs bind their physiological receptors"
XP_046427154.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_046425052.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_046425185.1	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
XP_046424097.1	24	Reactome: R-HSA-202040;Reactome: R-HSA-418594;Reactome: R-HSA-392451;Reactome: R-HSA-456926;Reactome: R-HSA-418217;Reactome: R-HSA-392170;Reactome: R-HSA-8964616;Reactome: R-HSA-4086398;Reactome: R-HSA-163359;Reactome: R-HSA-9009391;Reactome: R-HSA-6814122;Reactome: R-HSA-432040;Reactome: R-HSA-8964315;Reactome: R-HSA-381676;Reactome: R-HSA-420092;Reactome: R-HSA-428930;Reactome: R-HSA-416482;Reactome: R-HSA-418592;Reactome: R-HSA-500657;Reactome: R-HSA-400042;Reactome: R-HSA-392851;Reactome: R-HSA-418555;Reactome: R-HSA-416476;Reactome: R-HSA-418597	"G-protein activation";"G alpha (i) signalling events";"G beta:gamma signalling through PI3Kgamma";"Thrombin signalling through proteinase activated receptors (PARs)";"G beta:gamma signalling through PLC beta";"ADP signalling through P2Y purinoceptor 12";"G beta:gamma signalling through CDC42";"Ca2+ pathway";"Glucagon signaling in metabolic regulation";"Extra-nuclear estrogen signaling";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"Vasopressin regulates renal water homeostasis via Aquaporins";"G beta:gamma signalling through BTK";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"Glucagon-type ligand receptors";"Thromboxane signalling through TP receptor";"G alpha (12/13) signalling events";"ADP signalling through P2Y purinoceptor 1";"Presynaptic function of Kainate receptors";"Adrenaline,noradrenaline inhibits insulin secretion";"Prostacyclin signalling through prostacyclin receptor";"G alpha (s) signalling events";"G alpha (q) signalling events";"G alpha (z) signalling events"
XP_046411079.1	3	Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-9018519	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"Estrogen-dependent gene expression"
XP_046410728.1	4	Reactome: R-HSA-112308;Reactome: R-HSA-419037;Reactome: R-HSA-5576892;Reactome: R-HSA-5576893	"Presynaptic depolarization and calcium channel opening";"NCAM1 interactions";"Phase 0 - rapid depolarisation";"Phase 2 - plateau phase"
XP_046414987.1	1	Reactome: R-HSA-6794361	"Neurexins and neuroligins"
XP_046416547.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046430207.1	2	Reactome: R-HSA-3928665;Reactome: R-HSA-2682334	"EPH-ephrin mediated repulsion of cells";"EPH-Ephrin signaling"
XP_046424984.1	11	Reactome: R-HSA-432040;Reactome: R-HSA-418594;KEGG: 00230+4.6.1.1;Reactome: R-HSA-170670;Reactome: R-HSA-163615;Reactome: R-HSA-5610787;Reactome: R-HSA-164378;Reactome: R-HSA-163359;Reactome: R-HSA-418597;Reactome: R-HSA-170660;Reactome: R-HSA-418555	"Vasopressin regulates renal water homeostasis via Aquaporins";"G alpha (i) signalling events";"Purine metabolism";"Adenylate cyclase inhibitory pathway";"PKA activation";"Hedgehog 'off' state";"PKA activation in glucagon signalling";"Glucagon signaling in metabolic regulation";"G alpha (z) signalling events";"Adenylate cyclase activating pathway";"G alpha (s) signalling events"
XP_046435457.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046416705.1	6	Reactome: R-HSA-8951430;Reactome: R-HSA-201722;Reactome: R-HSA-4641265;Reactome: R-HSA-3769402;Reactome: R-HSA-4086398;Reactome: R-HSA-4411364	"RUNX3 regulates WNT signaling";"Formation of the beta-catenin:TCF transactivating complex";"Repression of WNT target genes";"Deactivation of the beta-catenin transactivating complex";"Ca2+ pathway";"Binding of TCF/LEF:CTNNB1 to target gene promoters"
XP_046432400.1	6	Reactome: R-HSA-9648025;Reactome: R-HSA-141444;Reactome: R-HSA-68877;Reactome: R-HSA-2467813;Reactome: R-HSA-5663220;Reactome: R-HSA-2500257	"EML4 and NUDC in mitotic spindle formation";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Mitotic Prometaphase";"Separation of Sister Chromatids";"RHO GTPases Activate Formins";"Resolution of Sister Chromatid Cohesion"
XP_046436136.1	1	Reactome: R-HSA-6802952	"Signaling by BRAF and RAF fusions"
XP_046422083.1	3	Reactome: R-HSA-194840;Reactome: R-HSA-416482;Reactome: R-HSA-193648	"Rho GTPase cycle";"G alpha (12/13) signalling events";"NRAGE signals death through JNK"
XP_046420718.1	14	MetaCyc: PWY-8041;MetaCyc: PWY-6598;MetaCyc: PWY-7602;MetaCyc: PWY-7036;MetaCyc: PWY-7035;MetaCyc: PWY-7619;MetaCyc: PWY-7725;MetaCyc: PWY-5080;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7601;MetaCyc: PWY-7724;MetaCyc: PWY-5972;Reactome: R-HSA-75876;MetaCyc: PWY-6433	"Ultra-long-chain fatty acid biosynthesis";"Sciadonate biosynthesis";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis II";"(9Z)-tricosene biosynthesis";"Juniperonate biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Very long chain fatty acid biosynthesis I";"Fatty acid elongation";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Stearate biosynthesis I (animals)";"Synthesis of very long-chain fatty acyl-CoAs";"Hydroxylated fatty acid biosynthesis (plants)"
XP_046428841.1	1	Reactome: R-HSA-6799198	"Complex I biogenesis"
XP_046413378.1	3	KEGG: 00030+2.7.6.1;KEGG: 00230+2.7.6.1;Reactome: R-HSA-73843	"Pentose phosphate pathway";"Purine metabolism";"5-Phosphoribose 1-diphosphate biosynthesis"
XP_046421694.1	3	Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-212436	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"Generic Transcription Pathway"
XP_046433013.1	7	Reactome: R-HSA-1362300;Reactome: R-HSA-156711;Reactome: R-HSA-69205;Reactome: R-HSA-1362277;Reactome: R-HSA-69656;Reactome: R-HSA-69202;Reactome: R-HSA-1538133	"Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1";"Polo-like kinase mediated events";"G1/S-Specific Transcription";"Transcription of E2F targets under negative control by DREAM complex";"Cyclin A:Cdk2-associated events at S phase entry";"Cyclin E associated events during G1/S transition";"G0 and Early G1"
XP_046431983.1	3	Reactome: R-HSA-2024096;Reactome: R-HSA-2206296;Reactome: R-HSA-2024101	"HS-GAG degradation";"MPS II - Hunter syndrome";"CS/DS degradation"
XP_046430612.1	39	Reactome: R-HSA-5654219;Reactome: R-HSA-5673001;Reactome: R-HSA-5654227;Reactome: R-HSA-190375;Reactome: R-HSA-5654726;Reactome: R-HSA-190322;Reactome: R-HSA-5654228;Reactome: R-HSA-5654727;Reactome: R-HSA-6811558;Reactome: R-HSA-5654687;Reactome: R-HSA-5654695;Reactome: R-HSA-5654688;Reactome: R-HSA-5654706;Reactome: R-HSA-5654689;Reactome: R-HSA-5654733;Reactome: R-HSA-5654710;Reactome: R-HSA-1257604;Reactome: R-HSA-5655302;Reactome: R-HSA-190372;Reactome: R-HSA-5654732;Reactome: R-HSA-5654712;Reactome: R-HSA-5658623;Reactome: R-HSA-1839130;Reactome: R-HSA-5654693;Reactome: R-HSA-2033514;Reactome: R-HSA-190373;Reactome: R-HSA-5654221;Reactome: R-HSA-5654719;Reactome: R-HSA-5654700;Reactome: R-HSA-5654699;Reactome: R-HSA-5654704;Reactome: R-HSA-5654720;Reactome: R-HSA-2219530;Reactome: R-HSA-2033519;Reactome: R-HSA-1839122;Reactome: R-HSA-109704;Reactome: R-HSA-5655253;Reactome: R-HSA-190371;Reactome: R-HSA-8853338	"Phospholipase C-mediated cascade: FGFR1";"RAF/MAP kinase cascade";"Phospholipase C-mediated cascade, FGFR3";"FGFR2c ligand binding and activation";"Negative regulation of FGFR1 signaling";"FGFR4 ligand binding and activation";"Phospholipase C-mediated cascade, FGFR4";"Negative regulation of FGFR2 signaling";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"Downstream signaling of activated FGFR1";"PI-3K cascade:FGFR2";"SHC-mediated cascade:FGFR1";"FRS-mediated FGFR3 signaling";"PI-3K cascade:FGFR1";"Negative regulation of FGFR4 signaling";"PI-3K cascade:FGFR3";"PIP3 activates AKT signaling";"Signaling by FGFR1 in disease";"FGFR3c ligand binding and activation";"Negative regulation of FGFR3 signaling";"FRS-mediated FGFR4 signaling";"FGFRL1 modulation of FGFR1 signaling";"Signaling by activated point mutants of FGFR3";"FRS-mediated FGFR1 signaling";"FGFR3 mutant receptor activation";"FGFR1c ligand binding and activation";"Phospholipase C-mediated cascade, FGFR2";"SHC-mediated cascade:FGFR4";"FRS-mediated FGFR2 signaling";"SHC-mediated cascade:FGFR2";"SHC-mediated cascade:FGFR3";"PI-3K cascade:FGFR4";"Constitutive Signaling by Aberrant PI3K in Cancer";"Activated point mutants of FGFR2";"Signaling by activated point mutants of FGFR1";"PI3K Cascade";"Signaling by FGFR2 in disease";"FGFR3b ligand binding and activation";"Signaling by FGFR3 point mutants in cancer"
XP_046422619.1	6	MetaCyc: PWY-7656;KEGG: 00073+1.2.1.84;MetaCyc: PWY-6733;Reactome: R-HSA-9640463;MetaCyc: PWY-5884;MetaCyc: PWY-7782	"Spodoptera littoralis pheromone biosynthesis";"Cutin, suberine and wax biosynthesis";"Sporopollenin precursors biosynthesis";"Wax biosynthesis";"Wax esters biosynthesis I";"Plasmalogen biosynthesis"
XP_046411658.1	2	Reactome: R-HSA-1169408;Reactome: R-HSA-168276	"ISG15 antiviral mechanism";"NS1 Mediated Effects on Host Pathways"
XP_046416842.1	1	Reactome: R-HSA-373080	"Class B/2 (Secretin family receptors)"
XP_046424044.1	20	Reactome: R-HSA-5696400;Reactome: R-HSA-5685938;Reactome: R-HSA-110320;Reactome: R-HSA-6782135;Reactome: R-HSA-5651801;Reactome: R-HSA-174411;Reactome: R-HSA-110312;Reactome: R-HSA-5685942;Reactome: R-HSA-5693607;Reactome: R-HSA-6782210;Reactome: R-HSA-5656169;Reactome: R-HSA-176187;Reactome: R-HSA-5693616;Reactome: R-HSA-6804756;Reactome: R-HSA-69473;Reactome: R-HSA-5696397;Reactome: R-HSA-5656121;Reactome: R-HSA-110314;Reactome: R-HSA-69091;Reactome: R-HSA-5655862	"Dual Incision in GG-NER";"HDR through Single Strand Annealing (SSA)";"Translesion Synthesis by POLH";"Dual incision in TC-NER";"PCNA-Dependent Long Patch Base Excision Repair";"Polymerase switching on the C-strand of the telomere";"Translesion synthesis by REV1";"HDR through Homologous Recombination (HRR)";"Processing of DNA double-strand break ends";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Termination of translesion DNA synthesis";"Activation of ATR in response to replication stress";"Presynaptic phase of homologous DNA pairing and strand exchange";"Regulation of TP53 Activity through Phosphorylation";"G2/M DNA damage checkpoint";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Translesion synthesis by POLI";"Recognition of DNA damage by PCNA-containing replication complex";"Polymerase switching";"Translesion synthesis by POLK"
XP_046418260.1	29	Reactome: R-HSA-5685938;Reactome: R-HSA-5693554;Reactome: R-HSA-6803204;Reactome: R-HSA-349425;Reactome: R-HSA-2559586;Reactome: R-HSA-5693579;Reactome: R-HSA-6804757;Reactome: R-HSA-5685942;Reactome: R-HSA-912446;Reactome: R-HSA-5693607;Reactome: R-HSA-5693548;KEGG: 05165+2.7.11.1;Reactome: R-HSA-5693568;KEGG: 04150+2.7.11.1;Reactome: R-HSA-5693616;Reactome: R-HSA-6796648;KEGG: 04151+2.7.11.1;Reactome: R-HSA-6804760;Reactome: R-HSA-69541;KEGG: 05163+2.7.11.1;Reactome: R-HSA-6804756;Reactome: R-HSA-5693571;KEGG: 04926+2.7.11.1;Reactome: R-HSA-69473;Reactome: R-HSA-3371453;Reactome: R-HSA-5693565;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;Reactome: R-HSA-6803207	"HDR through Single Strand Annealing (SSA)";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"TP53 Regulates Transcription of Genes Involved in Cytochrome C Release";"Autodegradation of the E3 ubiquitin ligase COP1";"DNA Damage/Telomere Stress Induced Senescence";"Homologous DNA Pairing and Strand Exchange";"Regulation of TP53 Degradation";"HDR through Homologous Recombination (HRR)";"Meiotic recombination";"Processing of DNA double-strand break ends";"Sensing of DNA Double Strand Breaks";"Human papillomavirus infection";"Resolution of D-loop Structures through Holliday Junction Intermediates";"mTOR signaling pathway";"Presynaptic phase of homologous DNA pairing and strand exchange";"TP53 Regulates Transcription of DNA Repair Genes";"PI3K-Akt signaling pathway";"Regulation of TP53 Activity through Methylation";"Stabilization of p53";"Human cytomegalovirus infection";"Regulation of TP53 Activity through Phosphorylation";"Nonhomologous End-Joining (NHEJ)";"Relaxin signaling pathway";"G2/M DNA damage checkpoint";"Regulation of HSF1-mediated heat shock response";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Thermogenesis";"Human immunodeficiency virus 1 infection";"TP53 Regulates Transcription of Caspase Activators and Caspases"
XP_046414191.1	4	KEGG: 00510+2.4.1.259+2.4.1.261;Reactome: R-HSA-446193;KEGG: 00513+2.4.1.261;Reactome: R-HSA-4720454	"N-Glycan biosynthesis";"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"Various types of N-glycan biosynthesis";"Defective ALG9 causes ALG9-CDG (CDG-1l)"
XP_046411295.1	1	Reactome: R-HSA-5223345	"Miscellaneous transport and binding events"
XP_046424594.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046424155.1	6	Reactome: R-HSA-3371599;MetaCyc: PWY-7382;MetaCyc: PWY-6987;KEGG: 00780+6.3.4.15;Reactome: R-HSA-196780;KEGG: 00785+2.3.1.181	"Defective HLCS causes multiple carboxylase deficiency";"Lipoate biosynthesis and incorporation IV (yeast)";"Lipoate biosynthesis and incorporation III (Bacillus)";"Biotin metabolism";"Biotin transport and metabolism";"Lipoic acid metabolism"
XP_046430776.1	1	Reactome: R-HSA-6809371	"Formation of the cornified envelope"
XP_046424965.1	5	Reactome: R-HSA-427413;Reactome: R-HSA-5250924;Reactome: R-HSA-73772;Reactome: R-HSA-73762;Reactome: R-HSA-73863	"NoRC negatively regulates rRNA expression";"B-WICH complex positively regulates rRNA expression";"RNA Polymerase I Promoter Escape";"RNA Polymerase I Transcription Initiation";"RNA Polymerase I Transcription Termination"
XP_046421049.1	5	KEGG: 00310+1.2.4.2;MetaCyc: PWY-5084;KEGG: 00380+1.2.4.2;Reactome: R-HSA-389661;KEGG: 00020+1.2.4.2	"Lysine degradation";"2-oxoglutarate decarboxylation to succinyl-CoA";"Tryptophan metabolism";"Glyoxylate metabolism and glycine degradation";"Citrate cycle (TCA cycle)"
XP_046424880.1	7	KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04926+2.7.11.1	"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Thermogenesis";"Human cytomegalovirus infection";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Relaxin signaling pathway"
XP_046423245.1	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
XP_046422134.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_046410830.1	6	Reactome: R-HSA-3769402;Reactome: R-HSA-452723;Reactome: R-HSA-6785807;Reactome: R-HSA-8986944;Reactome: R-HSA-2892247;Reactome: R-HSA-2892245	"Deactivation of the beta-catenin transactivating complex";"Transcriptional regulation of pluripotent stem cells";"Interleukin-4 and Interleukin-13 signaling";"Transcriptional Regulation by MECP2";"POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation";"POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation"
XP_046419153.1	9	Reactome: R-HSA-6802955;Reactome: R-HSA-114608;Reactome: R-HSA-5674135;Reactome: R-HSA-6802952;Reactome: R-HSA-9649948;Reactome: R-HSA-6802948;Reactome: R-HSA-6802946;Reactome: R-HSA-6798695;Reactome: R-HSA-445355	"Paradoxical activation of RAF signaling by kinase inactive BRAF";"Platelet degranulation";"MAP2K and MAPK activation";"Signaling by BRAF and RAF fusions";"Signaling downstream of RAS mutants";"Signaling by high-kinase activity BRAF mutants";"Signaling by moderate kinase activity BRAF mutants";"Neutrophil degranulation";"Smooth Muscle Contraction"
XP_046421040.1	2	Reactome: R-HSA-3295583;Reactome: R-HSA-418890	"TRP channels";"Role of second messengers in netrin-1 signaling"
XP_046432028.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_046410800.1	4	Reactome: R-HSA-1650814;Reactome: R-HSA-1442490;Reactome: R-HSA-8948216;Reactome: R-HSA-2022090	"Collagen biosynthesis and modifying enzymes";"Collagen degradation";"Collagen chain trimerization";"Assembly of collagen fibrils and other multimeric structures"
XP_046432063.1	6	MetaCyc: PWY-7790;KEGG: 00983+2.4.2.10;MetaCyc: PWY-7791;MetaCyc: PWY-5686;KEGG: 00240+2.4.2.10;Reactome: R-HSA-500753	"UMP biosynthesis II";"Drug metabolism - other enzymes";"UMP biosynthesis III";"UMP biosynthesis I";"Pyrimidine metabolism";"Pyrimidine biosynthesis"
XP_046424425.1	2	Reactome: R-HSA-426486;Reactome: R-HSA-203927	"Small interfering RNA (siRNA) biogenesis";"MicroRNA (miRNA) biogenesis"
XP_046432694.1	2	Reactome: R-HSA-5576892;Reactome: R-HSA-445095	"Phase 0 - rapid depolarisation";"Interaction between L1 and Ankyrins"
XP_046434886.1	12	KEGG: 00630+6.2.1.1;MetaCyc: PWY-5108;KEGG: 00010+6.2.1.1;KEGG: 00680+6.2.1.1;MetaCyc: PWY-5133;MetaCyc: PWY-7857;MetaCyc: PWY-6672;KEGG: 00720+6.2.1.1;MetaCyc: PWY-5132;KEGG: 00620+6.2.1.1;KEGG: 00640+6.2.1.1;MetaCyc: PWY-7118	"Glyoxylate and dicarboxylate metabolism";"L-isoleucine biosynthesis V";"Glycolysis / Gluconeogenesis";"Methane metabolism";"Colupulone and cohumulone biosynthesis";"Adlupulone and adhumulone biosynthesis";"Cis-genanyl-coa degradation";"Carbon fixation pathways in prokaryotes";"Lupulone and humulone biosynthesis";"Pyruvate metabolism";"Propanoate metabolism";"Chitin degradation to ethanol"
XP_046412351.1	1	Reactome: R-HSA-71064	"Lysine catabolism"
XP_046428440.1	7	KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1	"Human cytomegalovirus infection";"Thermogenesis";"Relaxin signaling pathway";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"PI3K-Akt signaling pathway";"mTOR signaling pathway"
XP_046423669.1	1	Reactome: R-HSA-196843	"Vitamin B2 (riboflavin) metabolism"
XP_046433587.1	2	Reactome: R-HSA-425397;Reactome: R-HSA-5619061	"Transport of vitamins, nucleosides, and related molecules";"Defective SLC33A1 causes spastic paraplegia 42 (SPG42)"
XP_046420989.1	1	Reactome: R-HSA-1655829	"Regulation of cholesterol biosynthesis by SREBP (SREBF)"
XP_046436685.1	12	Reactome: R-HSA-3371497;Reactome: R-HSA-6807878;Reactome: R-HSA-5663220;Reactome: R-HSA-2500257;Reactome: R-HSA-9648025;Reactome: R-HSA-141444;Reactome: R-HSA-9609690;Reactome: R-HSA-68877;Reactome: R-HSA-2467813;Reactome: R-HSA-6811436;Reactome: R-HSA-9646399;Reactome: R-HSA-2132295	"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-mediated anterograde transport";"RHO GTPases Activate Formins";"Resolution of Sister Chromatid Cohesion";"EML4 and NUDC in mitotic spindle formation";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"HCMV Early Events";"Mitotic Prometaphase";"Separation of Sister Chromatids";"COPI-independent Golgi-to-ER retrograde traffic";"Aggrephagy";"MHC class II antigen presentation"
XP_046418150.1	1	Reactome: R-HSA-1445148	"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
XP_046433660.1	6	Reactome: R-HSA-1855204;MetaCyc: PWY-6368;KEGG: 00562+3.1.3.36;KEGG: 04070+3.1.3.36;Reactome: R-HSA-1855183;Reactome: R-HSA-194840	"Synthesis of IP3 and IP4 in the cytosol";"3-phosphoinositide degradation";"Inositol phosphate metabolism";"Phosphatidylinositol signaling system";"Synthesis of IP2, IP, and Ins in the cytosol";"Rho GTPase cycle"
XP_046416784.1	1	Reactome: R-HSA-2151201	"Transcriptional activation of mitochondrial biogenesis"
XP_046420307.1	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
XP_046427326.1	3	Reactome: R-HSA-429947;Reactome: R-HSA-380994;Reactome: R-HSA-450604	"Deadenylation of mRNA";"ATF4 activates genes in response to endoplasmic reticulum stress";"KSRP (KHSRP) binds and destabilizes mRNA"
XP_046417000.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046435201.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_046412168.1	3	Reactome: R-HSA-196757;KEGG: 00790+6.3.2.17;MetaCyc: PWY-2161	"Metabolism of folate and pterines";"Folate biosynthesis";"Folate polyglutamylation"
XP_046435095.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_046428651.1	1	Reactome: R-HSA-525793	"Myogenesis"
XP_046416359.1	1	Reactome: R-HSA-5693568	"Resolution of D-loop Structures through Holliday Junction Intermediates"
XP_046422028.1	6	MetaCyc: PWY-5530;KEGG: 00030+3.1.1.17;KEGG: 00930+3.1.1.17;MetaCyc: PWY-2221;KEGG: 00053+3.1.1.17;MetaCyc: PWY-7165	"Sorbitol biosynthesis II";"Pentose phosphate pathway";"Caprolactam degradation";"Entner-Doudoroff pathway III (semi-phosphorylative)";"Ascorbate and aldarate metabolism";"L-ascorbate biosynthesis VI (engineered pathway)"
XP_046412139.1	1	Reactome: R-HSA-9616222	"Transcriptional regulation of granulopoiesis"
XP_046413900.1	5	Reactome: R-HSA-159231;Reactome: R-HSA-72187;Reactome: R-HSA-72163;Reactome: R-HSA-73856;Reactome: R-HSA-77595	"Transport of Mature mRNA Derived from an Intronless Transcript";"mRNA 3'-end processing";"mRNA Splicing - Major Pathway";"RNA Polymerase II Transcription Termination";"Processing of Intronless Pre-mRNAs"
XP_046428469.1	3	Reactome: R-HSA-2206291;Reactome: R-HSA-6798695;Reactome: R-HSA-2024096	"MPS IIIC - Sanfilippo syndrome C";"Neutrophil degranulation";"HS-GAG degradation"
XP_046435162.1	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
XP_046414472.1	2	KEGG: 00561+2.3.1.20;KEGG: 00073+2.3.1.20	"Glycerolipid metabolism";"Cutin, suberine and wax biosynthesis"
XP_046416983.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046410432.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046436324.1	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
XP_046409397.1	3	Reactome: R-HSA-196807;Reactome: R-HSA-73621;Reactome: R-HSA-74259	"Nicotinate metabolism";"Pyrimidine catabolism";"Purine catabolism"
XP_046416063.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_046426928.1	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
XP_046417146.1	3	KEGG: 00051+2.7.1.3;Reactome: R-HSA-70350;Reactome: R-HSA-5657562	"Fructose and mannose metabolism";"Fructose catabolism";"Essential fructosuria"
XP_046414973.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046421743.1	4	Reactome: R-HSA-9615710;Reactome: R-HSA-3899300;Reactome: R-HSA-9646399;Reactome: R-HSA-9613829	"Late endosomal microautophagy";"SUMOylation of transcription cofactors";"Aggrephagy";"Chaperone Mediated Autophagy"
XP_046423389.1	1	Reactome: R-HSA-8949613	"Cristae formation"
XP_046418638.1	4	Reactome: R-HSA-8856825;Reactome: R-HSA-5696394;Reactome: R-HSA-8951664;Reactome: R-HSA-6781823	"Cargo recognition for clathrin-mediated endocytosis";"DNA Damage Recognition in GG-NER";"Neddylation";"Formation of TC-NER Pre-Incision Complex"
XP_046413497.1	11	Reactome: R-HSA-418555;Reactome: R-HSA-170660;Reactome: R-HSA-418597;Reactome: R-HSA-163359;Reactome: R-HSA-164378;Reactome: R-HSA-5610787;Reactome: R-HSA-163615;Reactome: R-HSA-170670;KEGG: 00230+4.6.1.1;Reactome: R-HSA-418594;Reactome: R-HSA-432040	"G alpha (s) signalling events";"Adenylate cyclase activating pathway";"G alpha (z) signalling events";"Glucagon signaling in metabolic regulation";"PKA activation in glucagon signalling";"Hedgehog 'off' state";"PKA activation";"Adenylate cyclase inhibitory pathway";"Purine metabolism";"G alpha (i) signalling events";"Vasopressin regulates renal water homeostasis via Aquaporins"
XP_046420663.1	2	Reactome: R-HSA-5693568;Reactome: R-HSA-6783310	"Resolution of D-loop Structures through Holliday Junction Intermediates";"Fanconi Anemia Pathway"
XP_046410376.1	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
XP_046428144.1	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6784531	"Major pathway of rRNA processing in the nucleolus and cytosol";"tRNA processing in the nucleus"
XP_046417078.1	4	Reactome: R-HSA-8856828;Reactome: R-HSA-3928662;Reactome: R-HSA-2029482;Reactome: R-HSA-5663213	"Clathrin-mediated endocytosis";"EPHB-mediated forward signaling";"Regulation of actin dynamics for phagocytic cup formation";"RHO GTPases Activate WASPs and WAVEs"
XP_046412520.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046426018.1	20	MetaCyc: PWY-7288;MetaCyc: PWY-7340;MetaCyc: PWY-7574;MetaCyc: PWY-7337;MetaCyc: PWY-7854;MetaCyc: PWY-7007;MetaCyc: PWY-7606;MetaCyc: PWY-7726;MetaCyc: PWY-735;KEGG: 00592+1.3.3.6;KEGG: 00640+1.3.3.6;MetaCyc: PWY-6837;KEGG: 00410+1.3.3.6;Reactome: R-HSA-9033241;MetaCyc: PWY-5136;MetaCyc: PWY-7858;MetaCyc: PWY-7291;MetaCyc: PWY-6920;KEGG: 00071+1.3.3.6;MetaCyc: PWY-7338	"Fatty acid beta-oxidation VII (yeast peroxisome)";"9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast)";"Propanoyl-coa degradation II";"10-cis-heptadecenoyl-CoA degradation (yeast)";"Crotonyl-coa/ethylmalonyl-coa/hydroxybutyryl-coa cycle (engineered)";"Methyl ketone biosynthesis (engineered)";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"Jasmonic acid biosynthesis";"alpha-Linolenic acid metabolism";"Propanoate metabolism";"Fatty acid beta-oxidation V (unsaturated, odd number, di-isomerase-dependent)";"beta-Alanine metabolism";"Peroxisomal protein import";"Fatty acid beta-oxidation II (plant peroxisome)";"(5Z)-dodecenoate biosynthesis II";"Oleate beta-oxidation (isomerase-dependent, yeast)";"6-gingerol analog biosynthesis (engineered)";"Fatty acid degradation";"10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast)"
XP_046421947.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_046430445.1	5	Reactome: R-HSA-5218921;Reactome: R-HSA-5658442;Reactome: R-HSA-8849471;Reactome: R-HSA-186763;Reactome: R-HSA-3928662	"VEGFR2 mediated cell proliferation";"Regulation of RAS by GAPs";"PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases";"Downstream signal transduction";"EPHB-mediated forward signaling"
XP_046424501.1	9	MetaCyc: PWY-7115;MetaCyc: PWY-5744;MetaCyc: PWY-7117;MetaCyc: PWY-5743;MetaCyc: PWY-5789;MetaCyc: PWY-6142;MetaCyc: PWY-241;Reactome: R-HSA-1475029;KEGG: 00910+4.2.1.1	"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"Glyoxylate assimilation";"C4 photosynthetic carbon assimilation cycle, PEPCK type";"3-hydroxypropanoate cycle";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"C4 photosynthetic carbon assimilation cycle, NADP-ME type";"Reversible hydration of carbon dioxide";"Nitrogen metabolism"
XP_046420235.1	10	Reactome: R-HSA-983231;Reactome: R-HSA-427413;Reactome: R-HSA-9022692;Reactome: R-HSA-9022699;Reactome: R-HSA-9022538;Reactome: R-HSA-3899300;Reactome: R-HSA-9022702;Reactome: R-HSA-9615017;Reactome: R-HSA-400206;Reactome: R-HSA-8936459	"Factors involved in megakaryocyte development and platelet production";"NoRC negatively regulates rRNA expression";"Regulation of MECP2 expression and activity";"MECP2 regulates neuronal receptors and channels";"Loss of MECP2 binding ability to 5mC-DNA";"SUMOylation of transcription cofactors";"MECP2 regulates transcription of neuronal ligands";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"Regulation of lipid metabolism by PPARalpha";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"
XP_046421797.1	2	Reactome: R-HSA-5689603;Reactome: R-HSA-5696394	"UCH proteinases";"DNA Damage Recognition in GG-NER"
XP_046412151.1	1	Reactome: R-HSA-6814848	"Glycerophospholipid catabolism"
XP_046409563.1	1	MetaCyc: PWY-7379	"Mrna capping II"
XP_046426927.1	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
XP_046411193.1	4	Reactome: R-HSA-1614603;KEGG: 00260+4.2.1.22;MetaCyc: PWY-801;KEGG: 00270+4.2.1.22	"Cysteine formation from homocysteine";"Glycine, serine and threonine metabolism";"Homocysteine and cysteine interconversion";"Cysteine and methionine metabolism"
XP_046435204.1	3	Reactome: R-HSA-383280;Reactome: R-HSA-8936459;Reactome: R-HSA-3214841	"Nuclear Receptor transcription pathway";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"PKMTs methylate histone lysines"
XP_046435690.1	1	MetaCyc: PWY-6308	"L-cysteine biosynthesis II (tRNA-dependent)"
XP_046433923.1	14	MetaCyc: PWY-6433;MetaCyc: PWY-5972;Reactome: R-HSA-75876;MetaCyc: PWY-7724;MetaCyc: PWY-7725;MetaCyc: PWY-7619;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7601;MetaCyc: PWY-5080;MetaCyc: PWY-6598;MetaCyc: PWY-7602;MetaCyc: PWY-7036;MetaCyc: PWY-8041;MetaCyc: PWY-7035	"Hydroxylated fatty acid biosynthesis (plants)";"Stearate biosynthesis I (animals)";"Synthesis of very long-chain fatty acyl-CoAs";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Juniperonate biosynthesis";"Fatty acid elongation";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis I";"Sciadonate biosynthesis";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis II";"Ultra-long-chain fatty acid biosynthesis";"(9Z)-tricosene biosynthesis"
XP_046427492.1	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_046432521.1	6	MetaCyc: PWY-6368;Reactome: R-HSA-1855183;KEGG: 00562+3.1.3.64;KEGG: 04070+3.1.3.64;Reactome: R-HSA-1660517;MetaCyc: PWY-6580	"3-phosphoinositide degradation";"Synthesis of IP2, IP, and Ins in the cytosol";"Inositol phosphate metabolism";"Phosphatidylinositol signaling system";"Synthesis of PIPs at the late endosome membrane";"Phosphatidylinositol biosynthesis I (bacteria)"
XP_046426673.1	2	KEGG: 00561+2.7.1.30;MetaCyc: PWY-4261	"Glycerolipid metabolism";"Glycerol degradation I"
XP_046418481.1	4	Reactome: R-HSA-76071;Reactome: R-HSA-749476;Reactome: R-HSA-76066;Reactome: R-HSA-76061	"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Transcription Initiation From Type 1 Promoter"
XP_046436679.1	12	Reactome: R-HSA-6807878;Reactome: R-HSA-3371497;Reactome: R-HSA-2500257;Reactome: R-HSA-5663220;Reactome: R-HSA-2467813;Reactome: R-HSA-9646399;Reactome: R-HSA-6811436;Reactome: R-HSA-68877;Reactome: R-HSA-9609690;Reactome: R-HSA-141444;Reactome: R-HSA-9648025;Reactome: R-HSA-2132295	"COPI-mediated anterograde transport";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"Resolution of Sister Chromatid Cohesion";"RHO GTPases Activate Formins";"Separation of Sister Chromatids";"Aggrephagy";"COPI-independent Golgi-to-ER retrograde traffic";"Mitotic Prometaphase";"HCMV Early Events";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"EML4 and NUDC in mitotic spindle formation";"MHC class II antigen presentation"
XP_046433825.1	7	KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1	"Thermogenesis";"Human cytomegalovirus infection";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Relaxin signaling pathway";"mTOR signaling pathway";"PI3K-Akt signaling pathway"
XP_046435492.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_046421825.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_046423470.1	2	Reactome: R-HSA-804914;Reactome: R-HSA-9029569	"Transport of fatty acids";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux"
XP_046427167.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046409689.1	1	Reactome: R-HSA-163125	"Post-translational modification: synthesis of GPI-anchored proteins"
XP_046430707.1	1	Reactome: R-HSA-418594	"G alpha (i) signalling events"
XP_046427312.1	2	Reactome: R-HSA-418457;Reactome: R-HSA-4086398	"cGMP effects";"Ca2+ pathway"
XP_046431160.1	1	Reactome: R-HSA-156581	"Methylation"
XP_046425823.1	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_046411664.1	2	Reactome: R-HSA-168276;Reactome: R-HSA-1169408	"NS1 Mediated Effects on Host Pathways";"ISG15 antiviral mechanism"
XP_046420272.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046427055.1	8	Reactome: R-HSA-5689880;Reactome: R-HSA-5620912;Reactome: R-HSA-380270;Reactome: R-HSA-8854518;Reactome: R-HSA-380284;Reactome: R-HSA-380320;Reactome: R-HSA-2565942;Reactome: R-HSA-380259	"Ub-specific processing proteases";"Anchoring of the basal body to the plasma membrane";"Recruitment of mitotic centrosome proteins and complexes";"AURKA Activation by TPX2";"Loss of proteins required for interphase microtubule organization from the centrosome";"Recruitment of NuMA to mitotic centrosomes";"Regulation of PLK1 Activity at G2/M Transition";"Loss of Nlp from mitotic centrosomes"
XP_046427089.1	1	Reactome: R-HSA-8964038	"LDL clearance"
XP_046433532.1	2	Reactome: R-HSA-446199;Reactome: R-HSA-4755609	"Synthesis of Dolichyl-phosphate";"Defective DHDDS causes retinitis pigmentosa 59"
XP_046431884.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046411177.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_046429192.1	2	Reactome: R-HSA-379716;Reactome: R-HSA-2408522	"Cytosolic tRNA aminoacylation";"Selenoamino acid metabolism"
XP_046412154.1	1	Reactome: R-HSA-6814848	"Glycerophospholipid catabolism"
XP_046423435.1	1	Reactome: R-HSA-2565942	"Regulation of PLK1 Activity at G2/M Transition"
XP_046427799.1	1	Reactome: R-HSA-196819	"Vitamin B1 (thiamin) metabolism"
XP_046422018.1	33	Reactome: R-HSA-9609690;Reactome: R-HSA-168325;Reactome: R-HSA-141444;Reactome: R-HSA-159236;Reactome: R-HSA-4570464;Reactome: R-HSA-4085377;Reactome: R-HSA-6784531;Reactome: R-HSA-165054;Reactome: R-HSA-180910;Reactome: R-HSA-170822;Reactome: R-HSA-68877;Reactome: R-HSA-180746;Reactome: R-HSA-5578749;Reactome: R-HSA-3301854;Reactome: R-HSA-168333;Reactome: R-HSA-159227;Reactome: R-HSA-5663220;Reactome: R-HSA-159231;Reactome: R-HSA-2467813;Reactome: R-HSA-3108214;Reactome: R-HSA-1169408;Reactome: R-HSA-9648025;Reactome: R-HSA-9610379;Reactome: R-HSA-4551638;Reactome: R-HSA-2500257;Reactome: R-HSA-3371453;Reactome: R-HSA-3232142;Reactome: R-HSA-4615885;Reactome: R-HSA-159230;Reactome: R-HSA-191859;Reactome: R-HSA-168276;Reactome: R-HSA-5619107;Reactome: R-HSA-168271	"HCMV Early Events";"Viral Messenger RNA Synthesis";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"SUMOylation of RNA binding proteins";"SUMOylation of SUMOylation proteins";"tRNA processing in the nucleus";"Rev-mediated nuclear export of HIV RNA";"Vpr-mediated nuclear import of PICs";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Mitotic Prometaphase";"Nuclear import of Rev protein";"Transcriptional regulation by small RNAs";"Nuclear Pore Complex (NPC) Disassembly";"NEP/NS2 Interacts with the Cellular Export Machinery";"Transport of the SLBP independent Mature mRNA";"RHO GTPases Activate Formins";"Transport of Mature mRNA Derived from an Intronless Transcript";"Separation of Sister Chromatids";"SUMOylation of DNA damage response and repair proteins";"ISG15 antiviral mechanism";"EML4 and NUDC in mitotic spindle formation";"HCMV Late Events";"SUMOylation of chromatin organization proteins";"Resolution of Sister Chromatid Cohesion";"Regulation of HSF1-mediated heat shock response";"SUMOylation of ubiquitinylation proteins";"SUMOylation of DNA replication proteins";"Transport of the SLBP Dependant Mature mRNA";"snRNP Assembly";"NS1 Mediated Effects on Host Pathways";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Transport of Ribonucleoproteins into the Host Nucleus"
XP_046413058.1	1	Reactome: R-HSA-6811440	"Retrograde transport at the Trans-Golgi-Network"
XP_046422243.1	1	Reactome: R-HSA-606279	"Deposition of new CENPA-containing nucleosomes at the centromere"
XP_046424010.1	1	Reactome: R-HSA-8873719	"RAB geranylgeranylation"
XP_046432292.1	4	MetaCyc: PWY-7849;MetaCyc: PWY-7394;KEGG: 00230+4.1.1.97;MetaCyc: PWY-5691	"Urate conversion to allantoin III";"Urate conversion to allantoin II";"Purine metabolism";"Urate conversion to allantoin I"
XP_046429439.1	1	Reactome: R-HSA-1632852	"Macroautophagy"
XP_046417827.1	3	Reactome: R-HSA-611105;Reactome: R-HSA-6799198;Reactome: R-HSA-1268020	"Respiratory electron transport";"Complex I biogenesis";"Mitochondrial protein import"
XP_046418306.1	1	Reactome: R-HSA-211945	"Phase I - Functionalization of compounds"
XP_046425792.1	2	Reactome: R-HSA-983168;Reactome: R-HSA-110320	"Antigen processing: Ubiquitination & Proteasome degradation";"Translesion Synthesis by POLH"
XP_046411764.1	4	Reactome: R-HSA-983712;Reactome: R-HSA-1222556;Reactome: R-HSA-77387;Reactome: R-HSA-917977	"Ion channel transport";"ROS and RNS production in phagocytes";"Insulin receptor recycling";"Transferrin endocytosis and recycling"
XP_046435684.1	7	Reactome: R-HSA-72706;Reactome: R-HSA-72702;Reactome: R-HSA-429947;Reactome: R-HSA-72649;Reactome: R-HSA-72662;Reactome: R-HSA-156827;Reactome: R-HSA-166208	"GTP hydrolysis and joining of the 60S ribosomal subunit";"Ribosomal scanning and start codon recognition";"Deadenylation of mRNA";"Translation initiation complex formation";"Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S";"L13a-mediated translational silencing of Ceruloplasmin expression";"mTORC1-mediated signalling"
XP_046419785.1	1	Reactome: R-HSA-390522	"Striated Muscle Contraction"
XP_046427534.1	1	Reactome: R-HSA-1632852	"Macroautophagy"
XP_046419925.1	8	KEGG: 00515+2.4.1.109;MetaCyc: PWY-7979;Reactome: R-HSA-5083633;MetaCyc: PWY-7921;KEGG: 00514+2.4.1.109;MetaCyc: PWY-7922;Reactome: R-HSA-5083629;Reactome: R-HSA-5173105	"Mannose type O-glycan biosynthesis";"Protein O-mannosylation III (mammals, core M3)";"Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1";"Protein O-mannosylation I (yeast)";"Other types of O-glycan biosynthesis";"Protein O-mannosylation II (mammals, core M1 and core M2)";"Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2";"O-linked glycosylation"
XP_046411818.1	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
XP_046426291.1	2	Reactome: R-HSA-73980;Reactome: R-HSA-749476	"RNA Polymerase III Transcription Termination";"RNA Polymerase III Abortive And Retractive Initiation"
XP_046421520.1	3	Reactome: R-HSA-6811438;Reactome: R-HSA-6807878;Reactome: R-HSA-6811440	"Intra-Golgi traffic";"COPI-mediated anterograde transport";"Retrograde transport at the Trans-Golgi-Network"
XP_046412220.1	1	KEGG: 00970+6.1.1.9	"Aminoacyl-tRNA biosynthesis"
XP_046431076.1	4	Reactome: R-HSA-3769402;Reactome: R-HSA-201722;Reactome: R-HSA-2122947;Reactome: R-HSA-4641265	"Deactivation of the beta-catenin transactivating complex";"Formation of the beta-catenin:TCF transactivating complex";"NOTCH1 Intracellular Domain Regulates Transcription";"Repression of WNT target genes"
XP_046412053.1	3	Reactome: R-HSA-983189;Reactome: R-HSA-6811434;Reactome: R-HSA-390471	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic";"Association of TriC/CCT with target proteins during biosynthesis"
XP_046431673.1	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
XP_046429785.1	2	Reactome: R-HSA-390522;Reactome: R-HSA-445355	"Striated Muscle Contraction";"Smooth Muscle Contraction"
XP_046415259.1	8	Reactome: R-HSA-5673001;KEGG: 00230+2.7.4.8;Reactome: R-HSA-9620244;Reactome: R-HSA-438066;Reactome: R-HSA-9617324;Reactome: R-HSA-9609736;Reactome: R-HSA-442982;MetaCyc: PWY-7221	"RAF/MAP kinase cascade";"Purine metabolism";"Long-term potentiation";"Unblocking of NMDA receptors, glutamate binding and activation";"Negative regulation of NMDA receptor-mediated neuronal transmission";"Assembly and cell surface presentation of NMDA receptors";"Ras activation upon Ca2+ influx through NMDA receptor";"Guanosine ribonucleotides de novo biosynthesis"
XP_046417818.1	7	MetaCyc: PWY-6363;KEGG: 00521+3.1.3.25;MetaCyc: PWY-4702;MetaCyc: PWY-2301;Reactome: R-HSA-1855183;KEGG: 04070+3.1.3.25;KEGG: 00562+3.1.3.25	"D-myo-inositol (1,4,5)-trisphosphate degradation";"Streptomycin biosynthesis";"Phytate degradation I";"Myo-inositol biosynthesis";"Synthesis of IP2, IP, and Ins in the cytosol";"Phosphatidylinositol signaling system";"Inositol phosphate metabolism"
XP_046430597.1	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046435535.1	2	Reactome: R-HSA-2151201;Reactome: R-HSA-400253	"Transcriptional activation of mitochondrial biogenesis";"Circadian Clock"
XP_046410261.1	2	Reactome: R-HSA-5678895;Reactome: R-HSA-382556	"Defective CFTR causes cystic fibrosis";"ABC-family proteins mediated transport"
XP_046409483.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046412170.1	3	Reactome: R-HSA-196757;KEGG: 00790+6.3.2.17;MetaCyc: PWY-2161	"Metabolism of folate and pterines";"Folate biosynthesis";"Folate polyglutamylation"
XP_046411568.1	1	Reactome: R-HSA-212436	"Generic Transcription Pathway"
XP_046422595.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046417114.1	4	KEGG: 00270+2.5.1.6;Reactome: R-HSA-156581;MetaCyc: PWY-5041;MetaCyc: PWY-5912	"Cysteine and methionine metabolism";"Methylation";"S-adenosyl-L-methionine cycle II";"2'-deoxymugineic acid phytosiderophore biosynthesis"
XP_046427394.1	1	KEGG: 04660+2.7.10.2	"T cell receptor signaling pathway"
XP_046419549.1	56	Reactome: R-HSA-5610780;Reactome: R-HSA-450408;Reactome: R-HSA-1236974;Reactome: R-HSA-211733;Reactome: R-HSA-4641258;Reactome: R-HSA-5632684;Reactome: R-HSA-9010553;Reactome: R-HSA-8941858;Reactome: R-HSA-350562;Reactome: R-HSA-5668541;Reactome: R-HSA-5676590;Reactome: R-HSA-9604323;Reactome: R-HSA-5362768;Reactome: R-HSA-69601;Reactome: R-HSA-69017;Reactome: R-HSA-5358346;Reactome: R-HSA-68949;Reactome: R-HSA-382556;Reactome: R-HSA-1169091;Reactome: R-HSA-195253;Reactome: R-HSA-174178;Reactome: R-HSA-2871837;Reactome: R-HSA-8854050;Reactome: R-HSA-9020702;Reactome: R-HSA-174113;Reactome: R-HSA-5687128;Reactome: R-HSA-68827;Reactome: R-HSA-5689603;Reactome: R-HSA-187577;Reactome: R-HSA-180534;Reactome: R-HSA-5607764;Reactome: R-HSA-69481;Reactome: R-HSA-1234176;Reactome: R-HSA-8948751;Reactome: R-HSA-5610783;Reactome: R-HSA-8852276;Reactome: R-HSA-5607761;Reactome: R-HSA-983168;Reactome: R-HSA-5658442;Reactome: R-HSA-174154;Reactome: R-HSA-8939902;Reactome: R-HSA-174184;Reactome: R-HSA-2467813;Reactome: R-HSA-174084;Reactome: R-HSA-8951664;Reactome: R-HSA-5689880;Reactome: R-HSA-349425;Reactome: R-HSA-1236978;Reactome: R-HSA-75815;Reactome: R-HSA-202424;Reactome: R-HSA-4641257;Reactome: R-HSA-4608870;Reactome: R-HSA-180585;Reactome: R-HSA-5678895;Reactome: R-HSA-5610785;Reactome: R-HSA-8939236	"Degradation of GLI1 by the proteasome";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"ER-Phagosome pathway";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Degradation of DVL";"Hedgehog 'on' state";"Regulation of expression of SLITs and ROBOs";"Regulation of RUNX3 expression and activity";"Regulation of ornithine decarboxylase (ODC)";"TNFR2 non-canonical NF-kB pathway";"NIK-->noncanonical NF-kB signaling";"Negative regulation of NOTCH4 signaling";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"CDK-mediated phosphorylation and removal of Cdc6";"Hedgehog ligand biogenesis";"Orc1 removal from chromatin";"ABC-family proteins mediated transport";"Activation of NF-kappaB in B cells";"Degradation of beta-catenin by the destruction complex";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"FCERI mediated NF-kB activation";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Interleukin-1 signaling";"SCF-beta-TrCP mediated degradation of Emi1";"MAPK6/MAPK4 signaling";"CDT1 association with the CDC6:ORC:origin complex";"UCH proteinases";"SCF(Skp2)-mediated degradation of p27/p21";"Vpu mediated degradation of CD4";"CLEC7A (Dectin-1) signaling";"G2/M Checkpoints";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of PTEN stability and activity";"Degradation of GLI2 by the proteasome";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Dectin-1 mediated noncanonical NF-kB signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Regulation of RAS by GAPs";"APC/C:Cdc20 mediated degradation of Securin";"Regulation of RUNX2 expression and activity";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Separation of Sister Chromatids";"Autodegradation of Cdh1 by Cdh1:APC/C";"Neddylation";"Ub-specific processing proteases";"Autodegradation of the E3 ubiquitin ligase COP1";"Cross-presentation of soluble exogenous antigens (endosomes)";"Ubiquitin-dependent degradation of Cyclin D";"Downstream TCR signaling";"Degradation of AXIN";"Asymmetric localization of PCP proteins";"Vif-mediated degradation of APOBEC3G";"Defective CFTR causes cystic fibrosis";"GLI3 is processed to GLI3R by the proteasome";"RUNX1 regulates transcription of genes involved in differentiation of HSCs"
XP_046410273.1	2	Reactome: R-HSA-429947;Reactome: R-HSA-6804115	"Deadenylation of mRNA";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"
XP_046428142.1	2	Reactome: R-HSA-6784531;Reactome: R-HSA-6791226	"tRNA processing in the nucleus";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046414410.1	5	Reactome: R-HSA-159231;Reactome: R-HSA-72163;Reactome: R-HSA-72187;Reactome: R-HSA-73856;Reactome: R-HSA-77595	"Transport of Mature mRNA Derived from an Intronless Transcript";"mRNA Splicing - Major Pathway";"mRNA 3'-end processing";"RNA Polymerase II Transcription Termination";"Processing of Intronless Pre-mRNAs"
XP_046426647.1	6	Reactome: R-HSA-5663220;Reactome: R-HSA-2500257;Reactome: R-HSA-9648025;Reactome: R-HSA-141444;Reactome: R-HSA-68877;Reactome: R-HSA-2467813	"RHO GTPases Activate Formins";"Resolution of Sister Chromatid Cohesion";"EML4 and NUDC in mitotic spindle formation";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Mitotic Prometaphase";"Separation of Sister Chromatids"
XP_046431687.1	3	Reactome: R-HSA-446193;KEGG: 00510+2.4.1.265;Reactome: R-HSA-4724325	"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"N-Glycan biosynthesis";"Defective ALG8 causes ALG8-CDG (CDG-1h)"
XP_046416238.1	1	KEGG: 00900+3.4.24.84	"Terpenoid backbone biosynthesis"
XP_046430951.1	4	KEGG: 04658+3.1.3.16;Reactome: R-HSA-180024;KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16	"Th1 and Th2 cell differentiation";"DARPP-32 events";"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
XP_046430659.1	3	Reactome: R-HSA-6783984;KEGG: 00670+2.1.2.10;KEGG: 00260+2.1.2.10	"Glycine degradation";"One carbon pool by folate";"Glycine, serine and threonine metabolism"
XP_046432020.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_046424402.1	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
XP_046429491.1	5	KEGG: 05235+3.1.3.16;Reactome: R-HSA-176407;KEGG: 04660+3.1.3.16;Reactome: R-HSA-5687128;KEGG: 04658+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"T cell receptor signaling pathway";"MAPK6/MAPK4 signaling";"Th1 and Th2 cell differentiation"
XP_046430960.1	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276	"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination"
XP_046434475.1	2	Reactome: R-HSA-1268020;Reactome: R-HSA-1362409	"Mitochondrial protein import";"Mitochondrial iron-sulfur cluster biogenesis"
XP_046413524.1	1	Reactome: R-HSA-9033241	"Peroxisomal protein import"
XP_046428714.1	6	KEGG: 00561+2.7.1.107;MetaCyc: PWY-7039;MetaCyc: PWY-7817;KEGG: 00564+2.7.1.107;Reactome: R-HSA-114508;KEGG: 04070+2.7.1.107	"Glycerolipid metabolism";"Phosphatidate metabolism, as a signaling molecule";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Glycerophospholipid metabolism";"Effects of PIP2 hydrolysis";"Phosphatidylinositol signaling system"
XP_046425346.1	1	Reactome: R-HSA-390648	"Muscarinic acetylcholine receptors"
XP_046416818.1	5	KEGG: 00785+6.3.1.20;MetaCyc: PWY-7382;MetaCyc: PWY-6987;Reactome: R-HSA-389661;KEGG: 00785+2.3.1.181	"Lipoic acid metabolism";"Lipoate biosynthesis and incorporation IV (yeast)";"Lipoate biosynthesis and incorporation III (Bacillus)";"Glyoxylate metabolism and glycine degradation";"Lipoic acid metabolism"
XP_046425123.1	8	Reactome: R-HSA-437239;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1	"Recycling pathway of L1";"Thermogenesis";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Human cytomegalovirus infection";"Relaxin signaling pathway"
XP_046417076.1	4	KEGG: 00270+4.1.1.50;MetaCyc: PWY-6834;Reactome: R-HSA-351202;KEGG: 00330+4.1.1.50	"Cysteine and methionine metabolism";"Spermidine biosynthesis III";"Metabolism of polyamines";"Arginine and proline metabolism"
XP_046416585.1	5	Reactome: R-HSA-3134975;Reactome: R-HSA-6798695;Reactome: R-HSA-1834941;Reactome: R-HSA-3249367;Reactome: R-HSA-3270619	"Regulation of innate immune responses to cytosolic DNA";"Neutrophil degranulation";"STING mediated induction of host immune responses";"STAT6-mediated induction of chemokines";"IRF3-mediated induction of type I IFN"
XP_046430879.1	12	Reactome: R-HSA-5693616;Reactome: R-HSA-5693554;Reactome: R-HSA-5685938;Reactome: R-HSA-69473;Reactome: R-HSA-6804756;Reactome: R-HSA-8873719;Reactome: R-HSA-3108214;Reactome: R-HSA-5693607;Reactome: R-HSA-5685942;Reactome: R-HSA-5693579;Reactome: R-HSA-5693568;Reactome: R-HSA-8876198	"Presynaptic phase of homologous DNA pairing and strand exchange";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"HDR through Single Strand Annealing (SSA)";"G2/M DNA damage checkpoint";"Regulation of TP53 Activity through Phosphorylation";"RAB geranylgeranylation";"SUMOylation of DNA damage response and repair proteins";"Processing of DNA double-strand break ends";"HDR through Homologous Recombination (HRR)";"Homologous DNA Pairing and Strand Exchange";"Resolution of D-loop Structures through Holliday Junction Intermediates";"RAB GEFs exchange GTP for GDP on RABs"
XP_046410125.1	2	Reactome: R-HSA-5693568;Reactome: R-HSA-6783310	"Resolution of D-loop Structures through Holliday Junction Intermediates";"Fanconi Anemia Pathway"
XP_046427573.1	1	Reactome: R-HSA-5620922	"BBSome-mediated cargo-targeting to cilium"
XP_046412533.1	2	Reactome: R-HSA-983231;Reactome: R-HSA-5205685	"Factors involved in megakaryocyte development and platelet production";"Pink/Parkin Mediated Mitophagy"
XP_046427057.1	8	Reactome: R-HSA-380284;Reactome: R-HSA-380259;Reactome: R-HSA-380320;Reactome: R-HSA-2565942;Reactome: R-HSA-5620912;Reactome: R-HSA-5689880;Reactome: R-HSA-8854518;Reactome: R-HSA-380270	"Loss of proteins required for interphase microtubule organization from the centrosome";"Loss of Nlp from mitotic centrosomes";"Recruitment of NuMA to mitotic centrosomes";"Regulation of PLK1 Activity at G2/M Transition";"Anchoring of the basal body to the plasma membrane";"Ub-specific processing proteases";"AURKA Activation by TPX2";"Recruitment of mitotic centrosome proteins and complexes"
XP_046427470.1	3	KEGG: 00250+3.5.1.1;KEGG: 00460+3.5.1.1;Reactome: R-HSA-8963693	"Alanine, aspartate and glutamate metabolism";"Cyanoamino acid metabolism";"Aspartate and asparagine metabolism"
XP_046419884.1	19	Reactome: R-HSA-9609736;Reactome: R-HSA-399719;Reactome: R-HSA-5578775;Reactome: R-HSA-936837;Reactome: R-HSA-9617324;Reactome: R-HSA-877300;Reactome: R-HSA-5576892;Reactome: R-HSA-111932;Reactome: R-HSA-9022692;Reactome: R-HSA-438066;Reactome: R-HSA-6802952;Reactome: R-HSA-9649948;Reactome: R-HSA-3371571;Reactome: R-HSA-442982;Reactome: R-HSA-6802955;Reactome: R-HSA-9620244;Reactome: R-HSA-6802946;Reactome: R-HSA-5673000;Reactome: R-HSA-5673001	"Assembly and cell surface presentation of NMDA receptors";"Trafficking of AMPA receptors";"Ion homeostasis";"Ion transport by P-type ATPases";"Negative regulation of NMDA receptor-mediated neuronal transmission";"Interferon gamma signaling";"Phase 0 - rapid depolarisation";"CaMK IV-mediated phosphorylation of CREB";"Regulation of MECP2 expression and activity";"Unblocking of NMDA receptors, glutamate binding and activation";"Signaling by BRAF and RAF fusions";"Signaling downstream of RAS mutants";"HSF1-dependent transactivation";"Ras activation upon Ca2+ influx through NMDA receptor";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"Long-term potentiation";"Signaling by moderate kinase activity BRAF mutants";"RAF activation";"RAF/MAP kinase cascade"
XP_046431678.1	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
XP_046430837.1	2	Reactome: R-HSA-977443;Reactome: R-HSA-1236394	"GABA receptor activation";"Signaling by ERBB4"
XP_046430834.1	2	Reactome: R-HSA-1236394;Reactome: R-HSA-977443	"Signaling by ERBB4";"GABA receptor activation"
XP_046413619.1	1	Reactome: R-HSA-6809371	"Formation of the cornified envelope"
XP_046434700.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_046428918.1	1	Reactome: R-HSA-73621	"Pyrimidine catabolism"
XP_046423323.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046433990.1	14	MetaCyc: PWY-5972;Reactome: R-HSA-75876;MetaCyc: PWY-7724;MetaCyc: PWY-6433;MetaCyc: PWY-6598;MetaCyc: PWY-7602;MetaCyc: PWY-7036;MetaCyc: PWY-8041;MetaCyc: PWY-7035;MetaCyc: PWY-7725;MetaCyc: PWY-7619;MetaCyc: PWY-7601;KEGG: 00062+2.3.1.199;MetaCyc: PWY-5080	"Stearate biosynthesis I (animals)";"Synthesis of very long-chain fatty acyl-CoAs";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Hydroxylated fatty acid biosynthesis (plants)";"Sciadonate biosynthesis";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis II";"Ultra-long-chain fatty acid biosynthesis";"(9Z)-tricosene biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Juniperonate biosynthesis";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Fatty acid elongation";"Very long chain fatty acid biosynthesis I"
XP_046431031.1	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
XP_046425082.1	1	Reactome: R-HSA-381753	"Olfactory Signaling Pathway"
XP_046423469.1	2	Reactome: R-HSA-804914;Reactome: R-HSA-9029569	"Transport of fatty acids";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux"
XP_046432398.1	2	Reactome: R-HSA-8856825;Reactome: R-HSA-8856828	"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis"
XP_046432609.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_046415108.1	11	Reactome: R-HSA-74259;MetaCyc: PWY-5695;MetaCyc: PWY-6607;Reactome: R-HSA-8851680;MetaCyc: PWY-6538;MetaCyc: PWY-6596;MetaCyc: PWY-6999;MetaCyc: PWY-6608;MetaCyc: PWY-6606;KEGG: 00230+1.17.1.4;MetaCyc: PWY-5497	"Purine catabolism";"Inosine 5'-phosphate degradation";"Guanosine nucleotides degradation I";"Butyrophilin (BTN) family interactions";"Caffeine degradation III (bacteria, via demethylation)";"Adenosine nucleotides degradation I";"Theophylline degradation";"Guanosine nucleotides degradation III";"Guanosine nucleotides degradation II";"Purine metabolism";"Purine nucleobases degradation II (anaerobic)"
XP_046435666.1	2	Reactome: R-HSA-5628897;Reactome: R-HSA-611105	"TP53 Regulates Metabolic Genes";"Respiratory electron transport"
XP_046413566.1	8	MetaCyc: PWY-3581;MetaCyc: PWY-5049;MetaCyc: PWY-5394;MetaCyc: PWY-6133;Reactome: R-HSA-209905;KEGG: 00350+1.14.16.2;KEGG: 00950+1.14.16.2;KEGG: 00790+1.14.16.2	"(S)-reticuline biosynthesis I";"Rosmarinic acid biosynthesis II";"Betalamic acid biosynthesis";"(S)-reticuline biosynthesis II";"Catecholamine biosynthesis";"Tyrosine metabolism";"Isoquinoline alkaloid biosynthesis";"Folate biosynthesis"
XP_046430654.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_046425746.1	13	Reactome: R-HSA-9633012;Reactome: R-HSA-72689;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-192823;Reactome: R-HSA-72706;Reactome: R-HSA-2408557;Reactome: R-HSA-1799339;Reactome: R-HSA-975957;Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-975956;Reactome: R-HSA-72764	"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Formation of a pool of free 40S subunits";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Viral mRNA Translation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Selenocysteine synthesis";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination"
XP_046422696.1	5	Reactome: R-HSA-5675221;KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;Reactome: R-HSA-112409;KEGG: 04658+3.1.3.16	"Negative regulation of MAPK pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"RAF-independent MAPK1/3 activation";"Th1 and Th2 cell differentiation"
XP_046429493.1	1	Reactome: R-HSA-419771	"Opsins"
XP_046419086.1	4	Reactome: R-HSA-72731;MetaCyc: PWY-4361;MetaCyc: PWY-7174;KEGG: 00270+5.3.1.23	"Recycling of eIF2:GDP";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation II";"Cysteine and methionine metabolism"
XP_046427810.1	4	Reactome: R-HSA-5685942;Reactome: R-HSA-5693554;Reactome: R-HSA-5693579;Reactome: R-HSA-5693568	"HDR through Homologous Recombination (HRR)";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Homologous DNA Pairing and Strand Exchange";"Resolution of D-loop Structures through Holliday Junction Intermediates"
XP_046421805.1	4	Reactome: R-HSA-111465;Reactome: R-HSA-176187;Reactome: R-HSA-5693607;Reactome: R-HSA-5689880	"Apoptotic cleavage of cellular proteins";"Activation of ATR in response to replication stress";"Processing of DNA double-strand break ends";"Ub-specific processing proteases"
XP_046414726.1	27	Reactome: R-HSA-159227;Reactome: R-HSA-168333;Reactome: R-HSA-168271;Reactome: R-HSA-4615885;Reactome: R-HSA-159230;Reactome: R-HSA-180746;Reactome: R-HSA-5578749;Reactome: R-HSA-191859;Reactome: R-HSA-168276;Reactome: R-HSA-3301854;Reactome: R-HSA-5619107;Reactome: R-HSA-4551638;Reactome: R-HSA-4085377;Reactome: R-HSA-165054;Reactome: R-HSA-6784531;Reactome: R-HSA-180910;Reactome: R-HSA-3371453;Reactome: R-HSA-3232142;Reactome: R-HSA-170822;Reactome: R-HSA-9609690;Reactome: R-HSA-159231;Reactome: R-HSA-3108214;Reactome: R-HSA-168325;Reactome: R-HSA-1169408;Reactome: R-HSA-159236;Reactome: R-HSA-4570464;Reactome: R-HSA-9610379	"Transport of the SLBP independent Mature mRNA";"NEP/NS2 Interacts with the Cellular Export Machinery";"Transport of Ribonucleoproteins into the Host Nucleus";"SUMOylation of DNA replication proteins";"Transport of the SLBP Dependant Mature mRNA";"Nuclear import of Rev protein";"Transcriptional regulation by small RNAs";"snRNP Assembly";"NS1 Mediated Effects on Host Pathways";"Nuclear Pore Complex (NPC) Disassembly";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"SUMOylation of chromatin organization proteins";"SUMOylation of SUMOylation proteins";"Rev-mediated nuclear export of HIV RNA";"tRNA processing in the nucleus";"Vpr-mediated nuclear import of PICs";"Regulation of HSF1-mediated heat shock response";"SUMOylation of ubiquitinylation proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"HCMV Early Events";"Transport of Mature mRNA Derived from an Intronless Transcript";"SUMOylation of DNA damage response and repair proteins";"Viral Messenger RNA Synthesis";"ISG15 antiviral mechanism";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"SUMOylation of RNA binding proteins";"HCMV Late Events"
XP_046419506.1	3	Reactome: R-HSA-3000157;Reactome: R-HSA-8874081;Reactome: R-HSA-3000171	"Laminin interactions";"MET activates PTK2 signaling";"Non-integrin membrane-ECM interactions"
XP_046412143.1	1	Reactome: R-HSA-9616222	"Transcriptional regulation of granulopoiesis"
XP_046413899.1	5	Reactome: R-HSA-73856;Reactome: R-HSA-77595;Reactome: R-HSA-159231;Reactome: R-HSA-72163;Reactome: R-HSA-72187	"RNA Polymerase II Transcription Termination";"Processing of Intronless Pre-mRNAs";"Transport of Mature mRNA Derived from an Intronless Transcript";"mRNA Splicing - Major Pathway";"mRNA 3'-end processing"
XP_046419922.1	8	MetaCyc: PWY-7921;KEGG: 00514+2.4.1.109;MetaCyc: PWY-7922;Reactome: R-HSA-5173105;Reactome: R-HSA-5083629;MetaCyc: PWY-7979;KEGG: 00515+2.4.1.109;Reactome: R-HSA-5083633	"Protein O-mannosylation I (yeast)";"Other types of O-glycan biosynthesis";"Protein O-mannosylation II (mammals, core M1 and core M2)";"O-linked glycosylation";"Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2";"Protein O-mannosylation III (mammals, core M3)";"Mannose type O-glycan biosynthesis";"Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1"
XP_046427788.1	58	Reactome: R-HSA-180585;Reactome: R-HSA-5678895;Reactome: R-HSA-5610785;Reactome: R-HSA-8939236;Reactome: R-HSA-8951664;Reactome: R-HSA-174084;Reactome: R-HSA-5689880;Reactome: R-HSA-349425;Reactome: R-HSA-1236978;Reactome: R-HSA-75815;Reactome: R-HSA-202424;Reactome: R-HSA-4641257;Reactome: R-HSA-4608870;Reactome: R-HSA-174154;Reactome: R-HSA-8939902;Reactome: R-HSA-174184;Reactome: R-HSA-2467813;Reactome: R-HSA-5607761;Reactome: R-HSA-5658442;Reactome: R-HSA-983168;Reactome: R-HSA-6798695;Reactome: R-HSA-68827;Reactome: R-HSA-5689603;Reactome: R-HSA-180534;Reactome: R-HSA-187577;Reactome: R-HSA-5607764;Reactome: R-HSA-69481;Reactome: R-HSA-8948751;Reactome: R-HSA-1234176;Reactome: R-HSA-5610783;Reactome: R-HSA-8852276;Reactome: R-HSA-9020702;Reactome: R-HSA-8854050;Reactome: R-HSA-174113;Reactome: R-HSA-5687128;Reactome: R-HSA-5362768;Reactome: R-HSA-5676590;Reactome: R-HSA-9604323;Reactome: R-HSA-5358346;Reactome: R-HSA-69601;Reactome: R-HSA-69017;Reactome: R-HSA-382556;Reactome: R-HSA-1169091;Reactome: R-HSA-68949;Reactome: R-HSA-5689901;Reactome: R-HSA-195253;Reactome: R-HSA-2871837;Reactome: R-HSA-174178;Reactome: R-HSA-450408;Reactome: R-HSA-5610780;Reactome: R-HSA-1236974;Reactome: R-HSA-4641258;Reactome: R-HSA-211733;Reactome: R-HSA-5632684;Reactome: R-HSA-350562;Reactome: R-HSA-9010553;Reactome: R-HSA-8941858;Reactome: R-HSA-5668541	"Vif-mediated degradation of APOBEC3G";"Defective CFTR causes cystic fibrosis";"GLI3 is processed to GLI3R by the proteasome";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Neddylation";"Autodegradation of Cdh1 by Cdh1:APC/C";"Ub-specific processing proteases";"Autodegradation of the E3 ubiquitin ligase COP1";"Cross-presentation of soluble exogenous antigens (endosomes)";"Ubiquitin-dependent degradation of Cyclin D";"Downstream TCR signaling";"Degradation of AXIN";"Asymmetric localization of PCP proteins";"APC/C:Cdc20 mediated degradation of Securin";"Regulation of RUNX2 expression and activity";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Separation of Sister Chromatids";"Dectin-1 mediated noncanonical NF-kB signaling";"Regulation of RAS by GAPs";"Antigen processing: Ubiquitination & Proteasome degradation";"Neutrophil degranulation";"CDT1 association with the CDC6:ORC:origin complex";"UCH proteinases";"Vpu mediated degradation of CD4";"SCF(Skp2)-mediated degradation of p27/p21";"CLEC7A (Dectin-1) signaling";"G2/M Checkpoints";"Regulation of PTEN stability and activity";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Degradation of GLI2 by the proteasome";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Interleukin-1 signaling";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"SCF-beta-TrCP mediated degradation of Emi1";"MAPK6/MAPK4 signaling";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"NIK-->noncanonical NF-kB signaling";"Negative regulation of NOTCH4 signaling";"Hedgehog ligand biogenesis";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"CDK-mediated phosphorylation and removal of Cdc6";"ABC-family proteins mediated transport";"Activation of NF-kappaB in B cells";"Orc1 removal from chromatin";"Metalloprotease DUBs";"Degradation of beta-catenin by the destruction complex";"FCERI mediated NF-kB activation";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Degradation of GLI1 by the proteasome";"ER-Phagosome pathway";"Degradation of DVL";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Hedgehog 'on' state";"Regulation of ornithine decarboxylase (ODC)";"Regulation of expression of SLITs and ROBOs";"Regulation of RUNX3 expression and activity";"TNFR2 non-canonical NF-kB pathway"
XP_046418185.1	4	Reactome: R-HSA-6782861;MetaCyc: PWY-7286;MetaCyc: PWY-7285;MetaCyc: PWY-6829	"Synthesis of wybutosine at G37 of tRNA(Phe)";"7-(3-amino-3-carboxypropyl)-wyosine biosynthesis";"Methylwyosine biosynthesis";"Trna methylation (yeast)"
XP_046419411.1	7	Reactome: R-HSA-9033241;Reactome: R-HSA-77111;KEGG: 00281+4.1.3.4;KEGG: 00280+4.1.3.4;KEGG: 00650+4.1.3.4;KEGG: 00072+4.1.3.4;MetaCyc: PWY-5074	"Peroxisomal protein import";"Synthesis of Ketone Bodies";"Geraniol degradation";"Valine, leucine and isoleucine degradation";"Butanoate metabolism";"Synthesis and degradation of ketone bodies";"Mevalonate degradation"
XP_046427555.1	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_046433790.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046429419.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046416648.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046432451.1	5	Reactome: R-HSA-8856828;Reactome: R-HSA-8875360;Reactome: R-HSA-6807004;Reactome: R-HSA-182971;Reactome: R-HSA-8856825	"Clathrin-mediated endocytosis";"InlB-mediated entry of Listeria monocytogenes into host cell";"Negative regulation of MET activity";"EGFR downregulation";"Cargo recognition for clathrin-mediated endocytosis"
XP_046428236.1	1	Reactome: R-HSA-83936	"Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"
XP_046436436.1	9	MetaCyc: PWY-6351;MetaCyc: PWY-7039;KEGG: 00562+3.1.4.11;Reactome: R-HSA-416476;Reactome: R-HSA-1855204;KEGG: 04070+3.1.4.11;MetaCyc: PWY-6367;Reactome: R-HSA-112043;MetaCyc: PWY-8052	"D-myo-inositol (1,4,5)-trisphosphate biosynthesis";"Phosphatidate metabolism, as a signaling molecule";"Inositol phosphate metabolism";"G alpha (q) signalling events";"Synthesis of IP3 and IP4 in the cytosol";"Phosphatidylinositol signaling system";"D-myo-inositol-5-phosphate metabolism";"PLC beta mediated events";"2-arachidonoylglycerol biosynthesis"
XP_046429680.1	15	Reactome: R-HSA-2559580;Reactome: R-HSA-9029569;Reactome: R-HSA-5687128;Reactome: R-HSA-8853884;Reactome: R-HSA-9022692;Reactome: R-HSA-5628897;Reactome: R-HSA-8948700;Reactome: R-HSA-2559585;Reactome: R-HSA-8986944;Reactome: R-HSA-4086398;Reactome: R-HSA-8943723;Reactome: R-HSA-1912408;Reactome: R-HSA-8936459;Reactome: R-HSA-8934593;Reactome: R-HSA-9018519	"Oxidative Stress Induced Senescence";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"MAPK6/MAPK4 signaling";"Transcriptional Regulation by VENTX";"Regulation of MECP2 expression and activity";"TP53 Regulates Metabolic Genes";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"Oncogene Induced Senescence";"Transcriptional Regulation by MECP2";"Ca2+ pathway";"Regulation of PTEN mRNA translation";"Pre-NOTCH Transcription and Translation";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Regulation of RUNX1 Expression and Activity";"Estrogen-dependent gene expression"
XP_046422491.1	1	Reactome: R-HSA-2559584	"Formation of Senescence-Associated Heterochromatin Foci (SAHF)"
XP_046433180.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046419779.1	1	Reactome: R-HSA-390522	"Striated Muscle Contraction"
XP_046435322.1	2	Reactome: R-HSA-983168;Reactome: R-HSA-8951664	"Antigen processing: Ubiquitination & Proteasome degradation";"Neddylation"
XP_046417965.1	19	MetaCyc: PWY-7198;KEGG: 00240+2.7.4.6;Reactome: R-HSA-380320;MetaCyc: PWY-7220;KEGG: 00983+2.7.4.6;MetaCyc: PWY-7176;MetaCyc: PWY-7205;MetaCyc: PWY-7197;MetaCyc: PWY-7224;Reactome: R-HSA-380270;MetaCyc: PWY-7227;MetaCyc: PWY-7226;MetaCyc: PWY-7187;MetaCyc: PWY-7184;MetaCyc: PWY-7210;MetaCyc: PWY-7222;MetaCyc: PWY-7221;MetaCyc: PWY-6545;KEGG: 00230+2.7.4.6	"Pyrimidine deoxyribonucleotides de novo biosynthesis IV";"Pyrimidine metabolism";"Recruitment of NuMA to mitotic centrosomes";"Adenosine deoxyribonucleotides de novo biosynthesis II";"Drug metabolism - other enzymes";"UTP and CTP de novo biosynthesis";"CMP phosphorylation";"Pyrimidine deoxyribonucleotide phosphorylation";"Purine deoxyribonucleosides salvage";"Recruitment of mitotic centrosome proteins and complexes";"Adenosine deoxyribonucleotides de novo biosynthesis";"Guanosine deoxyribonucleotides de novo biosynthesis I";"Pyrimidine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Guanosine deoxyribonucleotides de novo biosynthesis II";"Guanosine ribonucleotides de novo biosynthesis";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Purine metabolism"
XP_046415110.1	1	Reactome: R-HSA-162791	"Attachment of GPI anchor to uPAR"
XP_046429730.1	5	Reactome: R-HSA-446199;KEGG: 00510+1.3.1.94;Reactome: R-HSA-193048;MetaCyc: PWY-6129;Reactome: R-HSA-4755579	"Synthesis of Dolichyl-phosphate";"N-Glycan biosynthesis";"Androgen biosynthesis";"Dolichol and dolichyl phosphate biosynthesis";"Defective SRD5A3 causes SRD5A3-CDG (CDG-1q) and KHRZ"
XP_046435382.1	2	Reactome: R-HSA-8856828;Reactome: R-HSA-8856825	"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis"
XP_046420811.1	5	Reactome: R-HSA-8963693;Reactome: R-HSA-9633012;KEGG: 00250+6.3.5.4;Reactome: R-HSA-380994;Reactome: R-HSA-9648895	"Aspartate and asparagine metabolism";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Alanine, aspartate and glutamate metabolism";"ATF4 activates genes in response to endoplasmic reticulum stress";"Response of EIF2AK1 (HRI) to heme deficiency"
XP_046424632.1	5	Reactome: R-HSA-110328;Reactome: R-HSA-110357;Reactome: R-HSA-110329;Reactome: R-HSA-5221030;Reactome: R-HSA-3108214	"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"Displacement of DNA glycosylase by APEX1";"Cleavage of the damaged pyrimidine";"TET1,2,3 and TDG demethylate DNA";"SUMOylation of DNA damage response and repair proteins"
XP_046415214.1	2	KEGG: 00230+2.7.4.8;MetaCyc: PWY-7221	"Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis"
XP_046426074.1	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
XP_046420667.1	2	KEGG: 00230+2.7.6.1;KEGG: 00030+2.7.6.1	"Purine metabolism";"Pentose phosphate pathway"
XP_046416677.1	6	Reactome: R-HSA-201722;Reactome: R-HSA-4641265;Reactome: R-HSA-8951430;Reactome: R-HSA-4086398;Reactome: R-HSA-4411364;Reactome: R-HSA-3769402	"Formation of the beta-catenin:TCF transactivating complex";"Repression of WNT target genes";"RUNX3 regulates WNT signaling";"Ca2+ pathway";"Binding of TCF/LEF:CTNNB1 to target gene promoters";"Deactivation of the beta-catenin transactivating complex"
XP_046410249.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_046415869.1	3	KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway"
XP_046409408.1	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
XP_046423741.1	7	Reactome: R-HSA-8953750;Reactome: R-HSA-3214841;Reactome: R-HSA-9609690;Reactome: R-HSA-212300;Reactome: R-HSA-8943724;Reactome: R-HSA-2559580;Reactome: R-HSA-5617472	"Transcriptional Regulation by E2F6";"PKMTs methylate histone lysines";"HCMV Early Events";"PRC2 methylates histones and DNA";"Regulation of PTEN gene transcription";"Oxidative Stress Induced Senescence";"Activation of anterior HOX genes in hindbrain development during early embryogenesis"
XP_046413562.1	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276	"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination"
XP_046431380.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046419580.1	2	Reactome: R-HSA-9603798;Reactome: R-HSA-1369062	"Class I peroxisomal membrane protein import";"ABC transporters in lipid homeostasis"
XP_046417877.1	2	Reactome: R-HSA-5693568;Reactome: R-HSA-6783310	"Resolution of D-loop Structures through Holliday Junction Intermediates";"Fanconi Anemia Pathway"
XP_046427189.1	11	Reactome: R-HSA-2559580;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;Reactome: R-HSA-450302;Reactome: R-HSA-171007;Reactome: R-HSA-4420097;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1	"Oxidative Stress Induced Senescence";"Thermogenesis";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"mTOR signaling pathway";"PI3K-Akt signaling pathway";"activated TAK1 mediates p38 MAPK activation";"p38MAPK events";"VEGFA-VEGFR2 Pathway";"Human cytomegalovirus infection";"Relaxin signaling pathway"
XP_046418110.1	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
XP_046428819.1	2	Reactome: R-HSA-5658442;Reactome: R-HSA-6802953	"Regulation of RAS by GAPs";"RAS signaling downstream of NF1 loss-of-function variants"
XP_046435529.1	2	Reactome: R-HSA-2151201;Reactome: R-HSA-400253	"Transcriptional activation of mitochondrial biogenesis";"Circadian Clock"
XP_046418879.1	1	Reactome: R-HSA-212436	"Generic Transcription Pathway"
XP_046431523.1	5	Reactome: R-HSA-111463;Reactome: R-HSA-111464;Reactome: R-HSA-111469;Reactome: R-HSA-111457;Reactome: R-HSA-9627069	"SMAC (DIABLO) binds to IAPs";"SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes";"SMAC, XIAP-regulated apoptotic response";"Release of apoptotic factors from the mitochondria";"Regulation of the apoptosome activity"
XP_046428294.1	2	Reactome: R-HSA-5339700;Reactome: R-HSA-4641265	"TCF7L2 mutants don't bind CTBP";"Repression of WNT target genes"
XP_046426003.1	2	Reactome: R-HSA-8866654;MetaCyc: PWY-7511	"E3 ubiquitin ligases ubiquitinate target proteins";"Protein ubiquitination"
XP_046419530.1	2	Reactome: R-HSA-6791226;Reactome: R-HSA-8849473	"Major pathway of rRNA processing in the nucleolus and cytosol";"PTK6 Expression"
XP_046411716.1	57	Reactome: R-HSA-5658442;Reactome: R-HSA-983168;Reactome: R-HSA-5607761;Reactome: R-HSA-6798695;Reactome: R-HSA-174184;Reactome: R-HSA-8939902;Reactome: R-HSA-174154;Reactome: R-HSA-2467813;Reactome: R-HSA-349425;Reactome: R-HSA-174084;Reactome: R-HSA-5689880;Reactome: R-HSA-8951664;Reactome: R-HSA-4608870;Reactome: R-HSA-4641257;Reactome: R-HSA-202424;Reactome: R-HSA-75815;Reactome: R-HSA-1236978;Reactome: R-HSA-5610785;Reactome: R-HSA-5678895;Reactome: R-HSA-180585;Reactome: R-HSA-8939236;Reactome: R-HSA-5632684;Reactome: R-HSA-4641258;Reactome: R-HSA-211733;Reactome: R-HSA-1236974;Reactome: R-HSA-450408;Reactome: R-HSA-5610780;Reactome: R-HSA-5668541;Reactome: R-HSA-8941858;Reactome: R-HSA-350562;Reactome: R-HSA-9010553;Reactome: R-HSA-69017;Reactome: R-HSA-69601;Reactome: R-HSA-5358346;Reactome: R-HSA-5362768;Reactome: R-HSA-9604323;Reactome: R-HSA-5676590;Reactome: R-HSA-174178;Reactome: R-HSA-2871837;Reactome: R-HSA-195253;Reactome: R-HSA-1169091;Reactome: R-HSA-68949;Reactome: R-HSA-382556;Reactome: R-HSA-9020702;Reactome: R-HSA-8854050;Reactome: R-HSA-5687128;Reactome: R-HSA-174113;Reactome: R-HSA-5607764;Reactome: R-HSA-187577;Reactome: R-HSA-180534;Reactome: R-HSA-5689603;Reactome: R-HSA-68827;Reactome: R-HSA-8852276;Reactome: R-HSA-5610783;Reactome: R-HSA-1234176;Reactome: R-HSA-8948751;Reactome: R-HSA-69481	"Regulation of RAS by GAPs";"Antigen processing: Ubiquitination & Proteasome degradation";"Dectin-1 mediated noncanonical NF-kB signaling";"Neutrophil degranulation";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Regulation of RUNX2 expression and activity";"APC/C:Cdc20 mediated degradation of Securin";"Separation of Sister Chromatids";"Autodegradation of the E3 ubiquitin ligase COP1";"Autodegradation of Cdh1 by Cdh1:APC/C";"Ub-specific processing proteases";"Neddylation";"Asymmetric localization of PCP proteins";"Degradation of AXIN";"Downstream TCR signaling";"Ubiquitin-dependent degradation of Cyclin D";"Cross-presentation of soluble exogenous antigens (endosomes)";"GLI3 is processed to GLI3R by the proteasome";"Defective CFTR causes cystic fibrosis";"Vif-mediated degradation of APOBEC3G";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Hedgehog 'on' state";"Degradation of DVL";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"ER-Phagosome pathway";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Degradation of GLI1 by the proteasome";"TNFR2 non-canonical NF-kB pathway";"Regulation of RUNX3 expression and activity";"Regulation of ornithine decarboxylase (ODC)";"Regulation of expression of SLITs and ROBOs";"CDK-mediated phosphorylation and removal of Cdc6";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Hedgehog ligand biogenesis";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Negative regulation of NOTCH4 signaling";"NIK-->noncanonical NF-kB signaling";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"FCERI mediated NF-kB activation";"Degradation of beta-catenin by the destruction complex";"Activation of NF-kappaB in B cells";"Orc1 removal from chromatin";"ABC-family proteins mediated transport";"Interleukin-1 signaling";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"MAPK6/MAPK4 signaling";"SCF-beta-TrCP mediated degradation of Emi1";"CLEC7A (Dectin-1) signaling";"SCF(Skp2)-mediated degradation of p27/p21";"Vpu mediated degradation of CD4";"UCH proteinases";"CDT1 association with the CDC6:ORC:origin complex";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Degradation of GLI2 by the proteasome";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of PTEN stability and activity";"G2/M Checkpoints"
XP_046412539.1	2	Reactome: R-HSA-5205685;Reactome: R-HSA-983231	"Pink/Parkin Mediated Mitophagy";"Factors involved in megakaryocyte development and platelet production"
XP_046421926.1	12	MetaCyc: PWY-7783;KEGG: 00592+3.1.1.4;KEGG: 00590+3.1.1.4;MetaCyc: PWY-6803;KEGG: 00565+3.1.1.4;MetaCyc: PWY-8051;MetaCyc: PWY-7417;KEGG: 00564+3.1.1.4;KEGG: 00591+3.1.1.4;MetaCyc: PWY-8053;MetaCyc: PWY-7416;MetaCyc: PWY-7409	"Plasmalogen degradation";"alpha-Linolenic acid metabolism";"Arachidonic acid metabolism";"Phosphatidylcholine acyl editing";"Ether lipid metabolism";"Anandamide biosynthesis I";"Phospholipid remodeling (phosphatidate, yeast)";"Glycerophospholipid metabolism";"Linoleic acid metabolism";"Anandamide biosynthesis II";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Phospholipid remodeling (phosphatidylethanolamine, yeast)"
XP_046422569.1	4	Reactome: R-HSA-5693554;Reactome: R-HSA-5685942;Reactome: R-HSA-5693579;Reactome: R-HSA-5693568	"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"HDR through Homologous Recombination (HRR)";"Homologous DNA Pairing and Strand Exchange";"Resolution of D-loop Structures through Holliday Junction Intermediates"
XP_046418085.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046425915.1	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
XP_046434228.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_046429768.1	3	Reactome: R-HSA-159230;Reactome: R-HSA-73856;Reactome: R-HSA-77588	"Transport of the SLBP Dependant Mature mRNA";"RNA Polymerase II Transcription Termination";"SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs"
XP_046433834.1	1	Reactome: R-HSA-1474228	"Degradation of the extracellular matrix"
XP_046426134.1	10	MetaCyc: PWY-6361;Reactome: R-HSA-1855167;Reactome: R-HSA-1855191;MetaCyc: PWY-6554;KEGG: 00562+2.7.1.158;MetaCyc: PWY-6362;MetaCyc: PWY-6369;KEGG: 04070+2.7.1.158;MetaCyc: PWY-4661;MetaCyc: PWY-6372	"1D-myo-inositol hexakisphosphate biosynthesis I (from Ins(1,4,5)P3)";"Synthesis of pyrophosphates in the cytosol";"Synthesis of IPs in the nucleus";"1D-myo-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3)";"Inositol phosphate metabolism";"1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)";"Inositol diphosphates biosynthesis";"Phosphatidylinositol signaling system";"1D-myo-inositol hexakisphosphate biosynthesis III (Spirodela polyrrhiza)";"1D-myo-inositol hexakisphosphate biosynthesis IV (Dictyostelium)"
XP_046409804.1	1	Reactome: R-HSA-425381	"Bicarbonate transporters"
XP_046435791.1	2	Reactome: R-HSA-5576893;Reactome: R-HSA-5576892	"Phase 2 - plateau phase";"Phase 0 - rapid depolarisation"
XP_046410378.1	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
XP_046434606.1	8	Reactome: R-HSA-432040;Reactome: R-HSA-983231;Reactome: R-HSA-180024;Reactome: R-HSA-381676;Reactome: R-HSA-442720;Reactome: R-HSA-5610787;Reactome: R-HSA-163615;Reactome: R-HSA-164378	"Vasopressin regulates renal water homeostasis via Aquaporins";"Factors involved in megakaryocyte development and platelet production";"DARPP-32 events";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"CREB1 phosphorylation through the activation of Adenylate Cyclase";"Hedgehog 'off' state";"PKA activation";"PKA activation in glucagon signalling"
XP_046432235.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
XP_046420636.1	2	KEGG: 00970+6.1.1.5;Reactome: R-HSA-379726	"Aminoacyl-tRNA biosynthesis";"Mitochondrial tRNA aminoacylation"
XP_046433561.1	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
XP_046427214.1	5	Reactome: R-HSA-427389;Reactome: R-HSA-73762;Reactome: R-HSA-6804758;Reactome: R-HSA-8943724;Reactome: R-HSA-3214815	"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"RNA Polymerase I Transcription Initiation";"Regulation of TP53 Activity through Acetylation";"Regulation of PTEN gene transcription";"HDACs deacetylate histones"
XP_046420148.1	2	Reactome: R-HSA-5628897;Reactome: R-HSA-611105	"TP53 Regulates Metabolic Genes";"Respiratory electron transport"
XP_046434260.1	3	Reactome: R-HSA-416482;Reactome: R-HSA-194840;Reactome: R-HSA-193648	"G alpha (12/13) signalling events";"Rho GTPase cycle";"NRAGE signals death through JNK"
XP_046418716.1	3	Reactome: R-HSA-4420097;KEGG: 04660+2.7.10.2;Reactome: R-HSA-391160	"VEGFA-VEGFR2 Pathway";"T cell receptor signaling pathway";"Signal regulatory protein family interactions"
XP_046432610.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_046431127.1	2	Reactome: R-HSA-390522;Reactome: R-HSA-445355	"Striated Muscle Contraction";"Smooth Muscle Contraction"
XP_046434752.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_046424759.1	8	Reactome: R-HSA-8953750;Reactome: R-HSA-111464;Reactome: R-HSA-111458;Reactome: R-HSA-6798695;Reactome: R-HSA-6803207;Reactome: R-HSA-9627069;Reactome: R-HSA-111459;Reactome: R-HSA-111463	"Transcriptional Regulation by E2F6";"SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes";"Formation of apoptosome";"Neutrophil degranulation";"TP53 Regulates Transcription of Caspase Activators and Caspases";"Regulation of the apoptosome activity";"Activation of caspases through apoptosome-mediated cleavage";"SMAC (DIABLO) binds to IAPs"
XP_046431385.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046412651.1	4	Reactome: R-HSA-2644606;Reactome: R-HSA-2122947;Reactome: R-HSA-2894862;Reactome: R-HSA-350054	"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH1 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Notch-HLH transcription pathway"
XP_046433757.1	6	Reactome: R-HSA-72649;Reactome: R-HSA-72702;Reactome: R-HSA-72695;Reactome: R-HSA-72706;Reactome: R-HSA-156827;Reactome: R-HSA-72689	"Translation initiation complex formation";"Ribosomal scanning and start codon recognition";"Formation of the ternary complex, and subsequently, the 43S complex";"GTP hydrolysis and joining of the 60S ribosomal subunit";"L13a-mediated translational silencing of Ceruloplasmin expression";"Formation of a pool of free 40S subunits"
XP_046412111.1	17	Reactome: R-HSA-8953750;Reactome: R-HSA-9616222;Reactome: R-HSA-113501;Reactome: R-HSA-1362300;Reactome: R-HSA-69205;Reactome: R-HSA-1362277;Reactome: R-HSA-69202;Reactome: R-HSA-69656;Reactome: R-HSA-2559580;Reactome: R-HSA-1912408;Reactome: R-HSA-111448;Reactome: R-HSA-139915;Reactome: R-HSA-2559585;Reactome: R-HSA-6804114;Reactome: R-HSA-2173796;Reactome: R-HSA-1538133;Reactome: R-HSA-69231	"Transcriptional Regulation by E2F6";"Transcriptional regulation of granulopoiesis";"Inhibition of replication initiation of damaged DNA by RB1/E2F1";"Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1";"G1/S-Specific Transcription";"Transcription of E2F targets under negative control by DREAM complex";"Cyclin E associated events during G1/S transition";"Cyclin A:Cdk2-associated events at S phase entry";"Oxidative Stress Induced Senescence";"Pre-NOTCH Transcription and Translation";"Activation of NOXA and translocation to mitochondria";"Activation of PUMA and translocation to mitochondria";"Oncogene Induced Senescence";"TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"G0 and Early G1";"Cyclin D associated events in G1"
XP_046418116.1	6	MetaCyc: PWY-6807;KEGG: 00604+3.2.1.23;KEGG: 00052+3.2.1.23;KEGG: 00531+3.2.1.23;KEGG: 00600+3.2.1.23;KEGG: 00511+3.2.1.23	"Xyloglucan degradation II (exoglucanase)";"Glycosphingolipid biosynthesis - ganglio series";"Galactose metabolism";"Glycosaminoglycan degradation";"Sphingolipid metabolism";"Other glycan degradation"
XP_046428466.1	1	Reactome: R-HSA-5610787	"Hedgehog 'off' state"
XP_046420929.1	11	Reactome: R-HSA-6804756;Reactome: R-HSA-163680;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04714+2.7.11.1;Reactome: R-HSA-9614657;Reactome: R-HSA-380972	"Regulation of TP53 Activity through Phosphorylation";"AMPK inhibits chREBP transcriptional activation activity";"Relaxin signaling pathway";"Human cytomegalovirus infection";"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Thermogenesis";"FOXO-mediated transcription of cell death genes";"Energy dependent regulation of mTOR by LKB1-AMPK"
XP_046427246.1	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046418465.1	2	Reactome: R-HSA-5576893;Reactome: R-HSA-5576892	"Phase 2 - plateau phase";"Phase 0 - rapid depolarisation"
XP_046422773.1	2	KEGG: 00340+2.1.1.22;Reactome: R-HSA-70921	"Histidine metabolism";"Histidine catabolism"
XP_046418114.1	6	KEGG: 00604+3.2.1.23;KEGG: 00052+3.2.1.23;MetaCyc: PWY-6807;KEGG: 00511+3.2.1.23;KEGG: 00600+3.2.1.23;KEGG: 00531+3.2.1.23	"Glycosphingolipid biosynthesis - ganglio series";"Galactose metabolism";"Xyloglucan degradation II (exoglucanase)";"Other glycan degradation";"Sphingolipid metabolism";"Glycosaminoglycan degradation"
XP_046422714.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_046433664.1	1	Reactome: R-HSA-6811440	"Retrograde transport at the Trans-Golgi-Network"
XP_046436336.1	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
XP_046417804.1	5	Reactome: R-HSA-3214858;Reactome: R-HSA-3247509;Reactome: R-HSA-201722;Reactome: R-HSA-8939243;Reactome: R-HSA-1266695	"RMTs methylate histone arginines";"Chromatin modifying enzymes";"Formation of the beta-catenin:TCF transactivating complex";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"Interleukin-7 signaling"
XP_046425369.1	1	Reactome: R-HSA-216083	"Integrin cell surface interactions"
XP_046431297.1	11	MetaCyc: PWY-6352;Reactome: R-HSA-109704;Reactome: R-HSA-1632852;KEGG: 04070+2.7.1.137;Reactome: R-HSA-1660514;Reactome: R-HSA-168138;Reactome: R-HSA-1660517;Reactome: R-HSA-5668599;Reactome: R-HSA-1660499;Reactome: R-HSA-1660516;KEGG: 00562+2.7.1.137	"3-phosphoinositide biosynthesis";"PI3K Cascade";"Macroautophagy";"Phosphatidylinositol signaling system";"Synthesis of PIPs at the Golgi membrane";"Toll Like Receptor 9 (TLR9) Cascade";"Synthesis of PIPs at the late endosome membrane";"RHO GTPases Activate NADPH Oxidases";"Synthesis of PIPs at the plasma membrane";"Synthesis of PIPs at the early endosome membrane";"Inositol phosphate metabolism"
XP_046409729.1	2	Reactome: R-HSA-983231;Reactome: R-HSA-383280	"Factors involved in megakaryocyte development and platelet production";"Nuclear Receptor transcription pathway"
XP_046423198.1	1	Reactome: R-HSA-8949664	"Processing of SMDT1"
XP_046416802.1	2	Reactome: R-HSA-8949664;Reactome: R-HSA-8949215	"Processing of SMDT1";"Mitochondrial calcium ion transport"
XP_046411333.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_046420926.1	1	Reactome: R-HSA-201681	"TCF dependent signaling in response to WNT"
XP_046427729.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_046423926.1	6	KEGG: 00073+1.2.1.84;MetaCyc: PWY-7656;Reactome: R-HSA-9640463;MetaCyc: PWY-6733;MetaCyc: PWY-5884;MetaCyc: PWY-7782	"Cutin, suberine and wax biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Wax biosynthesis";"Sporopollenin precursors biosynthesis";"Wax esters biosynthesis I";"Plasmalogen biosynthesis"
XP_046417781.1	1	Reactome: R-HSA-176974	"Unwinding of DNA"
XP_046424039.1	1	Reactome: R-HSA-2022928	"HS-GAG biosynthesis"
XP_046426971.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046429142.1	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276	"Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination"
XP_046428304.1	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
XP_046436298.1	7	Reactome: R-HSA-380284;Reactome: R-HSA-5620912;Reactome: R-HSA-380270;Reactome: R-HSA-2565942;Reactome: R-HSA-380320;Reactome: R-HSA-380259;Reactome: R-HSA-8854518	"Loss of proteins required for interphase microtubule organization from the centrosome";"Anchoring of the basal body to the plasma membrane";"Recruitment of mitotic centrosome proteins and complexes";"Regulation of PLK1 Activity at G2/M Transition";"Recruitment of NuMA to mitotic centrosomes";"Loss of Nlp from mitotic centrosomes";"AURKA Activation by TPX2"
XP_046418754.1	14	MetaCyc: PWY-7039;MetaCyc: PWY-6351;KEGG: 00562+3.1.4.11;KEGG: 04070+3.1.4.11;Reactome: R-HSA-500657;Reactome: R-HSA-1855204;Reactome: R-HSA-416476;MetaCyc: PWY-8052;Reactome: R-HSA-418217;Reactome: R-HSA-434316;Reactome: R-HSA-112043;Reactome: R-HSA-4086398;MetaCyc: PWY-6367;Reactome: R-HSA-399997	"Phosphatidate metabolism, as a signaling molecule";"D-myo-inositol (1,4,5)-trisphosphate biosynthesis";"Inositol phosphate metabolism";"Phosphatidylinositol signaling system";"Presynaptic function of Kainate receptors";"Synthesis of IP3 and IP4 in the cytosol";"G alpha (q) signalling events";"2-arachidonoylglycerol biosynthesis";"G beta:gamma signalling through PLC beta";"Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion";"PLC beta mediated events";"Ca2+ pathway";"D-myo-inositol-5-phosphate metabolism";"Acetylcholine regulates insulin secretion"
XP_046409690.1	1	Reactome: R-HSA-163125	"Post-translational modification: synthesis of GPI-anchored proteins"
XP_046422693.1	2	Reactome: R-HSA-8876198;Reactome: R-HSA-204005	"RAB GEFs exchange GTP for GDP on RABs";"COPII-mediated vesicle transport"
XP_046432877.1	27	Reactome: R-HSA-168271;Reactome: R-HSA-168333;Reactome: R-HSA-159227;Reactome: R-HSA-5619107;Reactome: R-HSA-3301854;Reactome: R-HSA-168276;Reactome: R-HSA-4615885;Reactome: R-HSA-191859;Reactome: R-HSA-5578749;Reactome: R-HSA-159230;Reactome: R-HSA-180746;Reactome: R-HSA-3371453;Reactome: R-HSA-180910;Reactome: R-HSA-3232142;Reactome: R-HSA-170822;Reactome: R-HSA-6784531;Reactome: R-HSA-4085377;Reactome: R-HSA-165054;Reactome: R-HSA-4551638;Reactome: R-HSA-9610379;Reactome: R-HSA-4570464;Reactome: R-HSA-1169408;Reactome: R-HSA-3108214;Reactome: R-HSA-168325;Reactome: R-HSA-159231;Reactome: R-HSA-9609690;Reactome: R-HSA-159236	"Transport of Ribonucleoproteins into the Host Nucleus";"NEP/NS2 Interacts with the Cellular Export Machinery";"Transport of the SLBP independent Mature mRNA";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Nuclear Pore Complex (NPC) Disassembly";"NS1 Mediated Effects on Host Pathways";"SUMOylation of DNA replication proteins";"snRNP Assembly";"Transcriptional regulation by small RNAs";"Transport of the SLBP Dependant Mature mRNA";"Nuclear import of Rev protein";"Regulation of HSF1-mediated heat shock response";"Vpr-mediated nuclear import of PICs";"SUMOylation of ubiquitinylation proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"tRNA processing in the nucleus";"SUMOylation of SUMOylation proteins";"Rev-mediated nuclear export of HIV RNA";"SUMOylation of chromatin organization proteins";"HCMV Late Events";"SUMOylation of RNA binding proteins";"ISG15 antiviral mechanism";"SUMOylation of DNA damage response and repair proteins";"Viral Messenger RNA Synthesis";"Transport of Mature mRNA Derived from an Intronless Transcript";"HCMV Early Events";"Transport of Mature mRNA derived from an Intron-Containing Transcript"
XP_046414474.1	2	KEGG: 00073+2.3.1.20;KEGG: 00561+2.3.1.20	"Cutin, suberine and wax biosynthesis";"Glycerolipid metabolism"
XP_046410516.1	6	KEGG: 04070+2.7.1.107;Reactome: R-HSA-114508;KEGG: 00564+2.7.1.107;MetaCyc: PWY-7817;MetaCyc: PWY-7039;KEGG: 00561+2.7.1.107	"Phosphatidylinositol signaling system";"Effects of PIP2 hydrolysis";"Glycerophospholipid metabolism";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Phosphatidate metabolism, as a signaling molecule";"Glycerolipid metabolism"
XP_046426793.1	4	Reactome: R-HSA-499943;KEGG: 00230+2.7.4.3;MetaCyc: PWY-7219;KEGG: 00730+2.7.4.3	"Interconversion of nucleotide di- and triphosphates";"Purine metabolism";"Adenosine ribonucleotides de novo biosynthesis";"Thiamine metabolism"
XP_046412368.1	32	Reactome: R-HSA-75955;Reactome: R-HSA-72203;Reactome: R-HSA-76042;Reactome: R-HSA-167243;Reactome: R-HSA-72163;Reactome: R-HSA-112382;Reactome: R-HSA-72086;Reactome: R-HSA-73776;Reactome: R-HSA-167161;Reactome: R-HSA-8851708;Reactome: R-HSA-9018519;Reactome: R-HSA-168325;Reactome: R-HSA-6807505;Reactome: R-HSA-167162;Reactome: R-HSA-113418;Reactome: R-HSA-167287;Reactome: R-HSA-167158;Reactome: R-HSA-167172;Reactome: R-HSA-77075;Reactome: R-HSA-167200;Reactome: R-HSA-6796648;Reactome: R-HSA-674695;Reactome: R-HSA-167242;Reactome: R-HSA-6803529;Reactome: R-HSA-167152;Reactome: R-HSA-167290;Reactome: R-HSA-167246;Reactome: R-HSA-72165;Reactome: R-HSA-75953;Reactome: R-HSA-167238;Reactome: R-HSA-73779;Reactome: R-HSA-167160	"RNA Polymerase II Transcription Elongation";"Processing of Capped Intron-Containing Pre-mRNA";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Tat-mediated HIV elongation arrest and recovery";"mRNA Splicing - Major Pathway";"Formation of RNA Pol II elongation complex";"mRNA Capping";"RNA Polymerase II Promoter Escape";"HIV Transcription Initiation";"Signaling by FGFR2 IIIa TM";"Estrogen-dependent gene expression";"Viral Messenger RNA Synthesis";"RNA polymerase II transcribes snRNA genes";"RNA Polymerase II HIV Promoter Escape";"Formation of the Early Elongation Complex";"HIV elongation arrest and recovery";"Formation of the HIV-1 Early Elongation Complex";"Transcription of the HIV genome";"RNA Pol II CTD phosphorylation and interaction with CE";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Pre-transcription Events";"Abortive elongation of HIV-1 transcript in the absence of Tat";"FGFR2 alternative splicing";"Formation of HIV elongation complex in the absence of HIV Tat";"Pausing and recovery of HIV elongation";"Tat-mediated elongation of the HIV-1 transcript";"mRNA Splicing - Minor Pathway";"RNA Polymerase II Transcription Initiation";"Pausing and recovery of Tat-mediated HIV elongation";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection"
XP_046427545.1	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
XP_046413285.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046435328.1	13	Reactome: R-HSA-2408557;Reactome: R-HSA-72706;Reactome: R-HSA-1799339;Reactome: R-HSA-72689;Reactome: R-HSA-9633012;Reactome: R-HSA-192823;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-156902;Reactome: R-HSA-72764;Reactome: R-HSA-975957;Reactome: R-HSA-6791226	"Selenocysteine synthesis";"GTP hydrolysis and joining of the 60S ribosomal subunit";"SRP-dependent cotranslational protein targeting to membrane";"Formation of a pool of free 40S subunits";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Viral mRNA Translation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Peptide chain elongation";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046409324.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_046429566.1	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
XP_046417038.1	5	Reactome: R-HSA-5628897;Reactome: R-HSA-111447;Reactome: R-HSA-1445148;Reactome: R-HSA-75035;Reactome: R-HSA-5625740	"TP53 Regulates Metabolic Genes";"Activation of BAD and translocation to mitochondria";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex";"RHO GTPases activate PKNs"
XP_046434937.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046416583.1	5	Reactome: R-HSA-3134975;Reactome: R-HSA-6798695;Reactome: R-HSA-1834941;Reactome: R-HSA-3249367;Reactome: R-HSA-3270619	"Regulation of innate immune responses to cytosolic DNA";"Neutrophil degranulation";"STING mediated induction of host immune responses";"STAT6-mediated induction of chemokines";"IRF3-mediated induction of type I IFN"
XP_046431928.1	13	Reactome: R-HSA-182218;Reactome: R-HSA-167590;Reactome: R-HSA-8964038;Reactome: R-HSA-2132295;Reactome: R-HSA-8856828;Reactome: R-HSA-8866427;Reactome: R-HSA-177504;Reactome: R-HSA-5099900;Reactome: R-HSA-5140745;Reactome: R-HSA-8856825;Reactome: R-HSA-437239;Reactome: R-HSA-416993;Reactome: R-HSA-3928665	"Nef Mediated CD8 Down-regulation";"Nef Mediated CD4 Down-regulation";"LDL clearance";"MHC class II antigen presentation";"Clathrin-mediated endocytosis";"VLDLR internalisation and degradation";"Retrograde neurotrophin signalling";"WNT5A-dependent internalization of FZD4";"WNT5A-dependent internalization of FZD2, FZD5 and ROR2";"Cargo recognition for clathrin-mediated endocytosis";"Recycling pathway of L1";"Trafficking of GluR2-containing AMPA receptors";"EPH-ephrin mediated repulsion of cells"
XP_046419502.1	3	Reactome: R-HSA-3000157;Reactome: R-HSA-8874081;Reactome: R-HSA-3000171	"Laminin interactions";"MET activates PTK2 signaling";"Non-integrin membrane-ECM interactions"
XP_046424988.1	11	Reactome: R-HSA-418555;Reactome: R-HSA-170660;Reactome: R-HSA-418597;Reactome: R-HSA-163359;Reactome: R-HSA-164378;Reactome: R-HSA-5610787;Reactome: R-HSA-163615;Reactome: R-HSA-170670;KEGG: 00230+4.6.1.1;Reactome: R-HSA-418594;Reactome: R-HSA-432040	"G alpha (s) signalling events";"Adenylate cyclase activating pathway";"G alpha (z) signalling events";"Glucagon signaling in metabolic regulation";"PKA activation in glucagon signalling";"Hedgehog 'off' state";"PKA activation";"Adenylate cyclase inhibitory pathway";"Purine metabolism";"G alpha (i) signalling events";"Vasopressin regulates renal water homeostasis via Aquaporins"
XP_046424754.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046411680.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_046430946.1	1	Reactome: R-HSA-8854691	"Interleukin-20 family signaling"
XP_046424001.1	1	Reactome: R-HSA-6794361	"Neurexins and neuroligins"
XP_046427212.1	5	Reactome: R-HSA-6804758;Reactome: R-HSA-427389;Reactome: R-HSA-73762;Reactome: R-HSA-3214815;Reactome: R-HSA-8943724	"Regulation of TP53 Activity through Acetylation";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"RNA Polymerase I Transcription Initiation";"HDACs deacetylate histones";"Regulation of PTEN gene transcription"
XP_046433836.1	1	Reactome: R-HSA-1474228	"Degradation of the extracellular matrix"
XP_046423619.1	5	MetaCyc: PWY-5381;MetaCyc: PWY-7761;Reactome: R-HSA-196807;KEGG: 00760+2.7.7.18;MetaCyc: PWY-5653	"Pyridine nucleotide cycling (plants)";"NAD salvage pathway II (PNC IV cycle)";"Nicotinate metabolism";"Nicotinate and nicotinamide metabolism";"NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde"
XP_046428751.1	5	Reactome: R-HSA-937041;Reactome: R-HSA-168164;Reactome: R-HSA-937072;Reactome: R-HSA-166166;Reactome: R-HSA-936964	"IKK complex recruitment mediated by RIP1";"Toll Like Receptor 3 (TLR3) Cascade";"TRAF6-mediated induction of TAK1 complex within TLR4 complex";"MyD88-independent TLR4 cascade";"Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon"
XP_046431077.1	4	Reactome: R-HSA-4641265;Reactome: R-HSA-201722;Reactome: R-HSA-2122947;Reactome: R-HSA-3769402	"Repression of WNT target genes";"Formation of the beta-catenin:TCF transactivating complex";"NOTCH1 Intracellular Domain Regulates Transcription";"Deactivation of the beta-catenin transactivating complex"
XP_046423033.1	2	Reactome: R-HSA-425366;Reactome: R-HSA-1483191	"Transport of bile salts and organic acids, metal ions and amine compounds";"Synthesis of PC"
XP_046428689.1	27	Reactome: R-HSA-112382;Reactome: R-HSA-72163;Reactome: R-HSA-9010553;Reactome: R-HSA-72203;Reactome: R-HSA-159231;Reactome: R-HSA-159236;Reactome: R-HSA-6803529;Reactome: R-HSA-167152;Reactome: R-HSA-8851708;Reactome: R-HSA-975956;Reactome: R-HSA-167242;Reactome: R-HSA-674695;Reactome: R-HSA-72086;Reactome: R-HSA-167200;Reactome: R-HSA-111367;Reactome: R-HSA-159227;Reactome: R-HSA-113418;Reactome: R-HSA-77588;Reactome: R-HSA-72165;Reactome: R-HSA-6807505;Reactome: R-HSA-77595;Reactome: R-HSA-975957;Reactome: R-HSA-159230;Reactome: R-HSA-191859;Reactome: R-HSA-72187;Reactome: R-HSA-167158;Reactome: R-HSA-73856	"Formation of RNA Pol II elongation complex";"mRNA Splicing - Major Pathway";"Regulation of expression of SLITs and ROBOs";"Processing of Capped Intron-Containing Pre-mRNA";"Transport of Mature mRNA Derived from an Intronless Transcript";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"FGFR2 alternative splicing";"Formation of HIV elongation complex in the absence of HIV Tat";"Signaling by FGFR2 IIIa TM";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Abortive elongation of HIV-1 transcript in the absence of Tat";"RNA Polymerase II Pre-transcription Events";"mRNA Capping";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"SLBP independent Processing of Histone Pre-mRNAs";"Transport of the SLBP independent Mature mRNA";"Formation of the Early Elongation Complex";"SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs";"mRNA Splicing - Minor Pathway";"RNA polymerase II transcribes snRNA genes";"Processing of Intronless Pre-mRNAs";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Transport of the SLBP Dependant Mature mRNA";"snRNP Assembly";"mRNA 3'-end processing";"Formation of the HIV-1 Early Elongation Complex";"RNA Polymerase II Transcription Termination"
XP_046411888.1	1	Reactome: R-HSA-425986	"Sodium/Proton exchangers"
XP_046411411.1	1	Reactome: R-HSA-420499	"Class C/3 (Metabotropic glutamate/pheromone receptors)"
XP_046432985.1	3	Reactome: R-HSA-1989781;Reactome: R-HSA-381340;Reactome: R-HSA-212436	"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation";"Generic Transcription Pathway"
XP_046423457.1	19	Reactome: R-HSA-525793;Reactome: R-HSA-5626467;Reactome: R-HSA-194840;Reactome: R-HSA-428543;Reactome: R-HSA-389359;Reactome: R-HSA-3928662;Reactome: R-HSA-4420097;Reactome: R-HSA-5663213;Reactome: R-HSA-114604;Reactome: R-HSA-5687128;Reactome: R-HSA-5663220;Reactome: R-HSA-8950505;Reactome: R-HSA-983231;Reactome: R-HSA-5625970;Reactome: R-HSA-182971;Reactome: R-HSA-2029482;Reactome: R-HSA-5627123;Reactome: R-HSA-418885;Reactome: R-HSA-8964616	"Myogenesis";"RHO GTPases activate IQGAPs";"Rho GTPase cycle";"Inactivation of CDC42 and RAC1";"CD28 dependent Vav1 pathway";"EPHB-mediated forward signaling";"VEGFA-VEGFR2 Pathway";"RHO GTPases Activate WASPs and WAVEs";"GPVI-mediated activation cascade";"MAPK6/MAPK4 signaling";"RHO GTPases Activate Formins";"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation";"Factors involved in megakaryocyte development and platelet production";"RHO GTPases activate KTN1";"EGFR downregulation";"Regulation of actin dynamics for phagocytic cup formation";"RHO GTPases activate PAKs";"DCC mediated attractive signaling";"G beta:gamma signalling through CDC42"
XP_046425882.1	3	Reactome: R-HSA-5578775;Reactome: R-HSA-936837;Reactome: R-HSA-418359	"Ion homeostasis";"Ion transport by P-type ATPases";"Reduction of cytosolic Ca++ levels"
XP_046413618.1	1	Reactome: R-HSA-6809371	"Formation of the cornified envelope"
XP_046436156.1	18	MetaCyc: PWY-7409;Reactome: R-HSA-1482839;MetaCyc: PWY-8053;MetaCyc: PWY-7416;KEGG: 00591+3.1.1.4;KEGG: 00564+3.1.1.4;MetaCyc: PWY-6803;Reactome: R-HSA-1482925;MetaCyc: PWY-7783;Reactome: R-HSA-1482801;MetaCyc: PWY-7417;MetaCyc: PWY-8051;Reactome: R-HSA-1482922;KEGG: 00565+3.1.1.4;Reactome: R-HSA-1482788;Reactome: R-HSA-1483166;KEGG: 00590+3.1.1.4;KEGG: 00592+3.1.1.4	"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Acyl chain remodelling of PE";"Anandamide biosynthesis II";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Linoleic acid metabolism";"Glycerophospholipid metabolism";"Phosphatidylcholine acyl editing";"Acyl chain remodelling of PG";"Plasmalogen degradation";"Acyl chain remodelling of PS";"Phospholipid remodeling (phosphatidate, yeast)";"Anandamide biosynthesis I";"Acyl chain remodelling of PI";"Ether lipid metabolism";"Acyl chain remodelling of PC";"Synthesis of PA";"Arachidonic acid metabolism";"alpha-Linolenic acid metabolism"
XP_046415699.1	2	Reactome: R-HSA-1660662;Reactome: R-HSA-390471	"Glycosphingolipid metabolism";"Association of TriC/CCT with target proteins during biosynthesis"
XP_046422824.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046423776.1	14	Reactome: R-HSA-2979096;Reactome: R-HSA-9017802;Reactome: R-HSA-193692;Reactome: R-HSA-1251985;Reactome: R-HSA-9013507;Reactome: R-HSA-2122948;Reactome: R-HSA-9013700;Reactome: R-HSA-2894862;Reactome: R-HSA-977225;Reactome: R-HSA-205043;Reactome: R-HSA-3928665;Reactome: R-HSA-2644606;Reactome: R-HSA-1474228;Reactome: R-HSA-6798695	"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Noncanonical activation of NOTCH3";"Regulated proteolysis of p75NTR";"Nuclear signaling by ERBB4";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Activated NOTCH1 Transmits Signal to the Nucleus";"NOTCH4 Activation and Transmission of Signal to the Nucleus";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Amyloid fiber formation";"NRIF signals cell death from the nucleus";"EPH-ephrin mediated repulsion of cells";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Degradation of the extracellular matrix";"Neutrophil degranulation"
XP_046428255.1	1	Reactome: R-HSA-83936	"Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"
XP_046434876.1	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
XP_046424899.1	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276	"Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination"
XP_046436311.1	4	MetaCyc: PWY-7494;MetaCyc: PWY-3722;KEGG: 00260+1.2.1.8+1.1.99.1;Reactome: R-HSA-6798163	"Choline degradation IV";"Glycine betaine biosynthesis II (Gram-positive bacteria)";"Glycine, serine and threonine metabolism";"Choline catabolism"
XP_046423548.1	16	Reactome: R-HSA-72649;Reactome: R-HSA-72764;Reactome: R-HSA-156902;Reactome: R-HSA-975957;Reactome: R-HSA-1799339;Reactome: R-HSA-72695;Reactome: R-HSA-192823;Reactome: R-HSA-72689;Reactome: R-HSA-975956;Reactome: R-HSA-72702;Reactome: R-HSA-6791226;Reactome: R-HSA-72706;Reactome: R-HSA-2408557;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-9633012	"Translation initiation complex formation";"Eukaryotic Translation Termination";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"Formation of the ternary complex, and subsequently, the 43S complex";"Viral mRNA Translation";"Formation of a pool of free 40S subunits";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Ribosomal scanning and start codon recognition";"Major pathway of rRNA processing in the nucleolus and cytosol";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Selenocysteine synthesis";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency"
XP_046415189.1	4	MetaCyc: PWY-6803;KEGG: 00592+3.1.1.32;MetaCyc: PWY-8051;KEGG: 00564+3.1.1.32	"Phosphatidylcholine acyl editing";"alpha-Linolenic acid metabolism";"Anandamide biosynthesis I";"Glycerophospholipid metabolism"
XP_046435104.1	4	MetaCyc: PWY-6906;KEGG: 00520+2.7.1.59;MetaCyc: PWY-6517;Reactome: R-HSA-446210	"Chitin derivatives degradation";"Amino sugar and nucleotide sugar metabolism";"N-acetylglucosamine degradation II";"Synthesis of UDP-N-acetyl-glucosamine"
XP_046434542.1	37	Reactome: R-HSA-9610379;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813;Reactome: R-HSA-1169408;Reactome: R-HSA-3108214;Reactome: R-HSA-159231;Reactome: R-HSA-3232142;Reactome: R-HSA-3371453;Reactome: R-HSA-2500257;Reactome: R-HSA-4551638;Reactome: R-HSA-168276;Reactome: R-HSA-5619107;Reactome: R-HSA-159230;Reactome: R-HSA-191859;Reactome: R-HSA-4615885;Reactome: R-HSA-168271;Reactome: R-HSA-4570464;Reactome: R-HSA-9639288;Reactome: R-HSA-159236;Reactome: R-HSA-141444;Reactome: R-HSA-9609690;Reactome: R-HSA-168325;Reactome: R-HSA-170822;Reactome: R-HSA-180910;Reactome: R-HSA-165054;Reactome: R-HSA-6784531;Reactome: R-HSA-4085377;Reactome: R-HSA-3301854;Reactome: R-HSA-2132295;Reactome: R-HSA-5578749;Reactome: R-HSA-180746;Reactome: R-HSA-68877;Reactome: R-HSA-5663220;Reactome: R-HSA-204005;Reactome: R-HSA-983170;Reactome: R-HSA-159227;Reactome: R-HSA-168333	"HCMV Late Events";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids";"ISG15 antiviral mechanism";"SUMOylation of DNA damage response and repair proteins";"Transport of Mature mRNA Derived from an Intronless Transcript";"SUMOylation of ubiquitinylation proteins";"Regulation of HSF1-mediated heat shock response";"Resolution of Sister Chromatid Cohesion";"SUMOylation of chromatin organization proteins";"NS1 Mediated Effects on Host Pathways";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Transport of the SLBP Dependant Mature mRNA";"snRNP Assembly";"SUMOylation of DNA replication proteins";"Transport of Ribonucleoproteins into the Host Nucleus";"SUMOylation of RNA binding proteins";"Amino acids regulate mTORC1";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"HCMV Early Events";"Viral Messenger RNA Synthesis";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Vpr-mediated nuclear import of PICs";"Rev-mediated nuclear export of HIV RNA";"tRNA processing in the nucleus";"SUMOylation of SUMOylation proteins";"Nuclear Pore Complex (NPC) Disassembly";"MHC class II antigen presentation";"Transcriptional regulation by small RNAs";"Nuclear import of Rev protein";"Mitotic Prometaphase";"RHO GTPases Activate Formins";"COPII-mediated vesicle transport";"Antigen Presentation: Folding, assembly and peptide loading of class I MHC";"Transport of the SLBP independent Mature mRNA";"NEP/NS2 Interacts with the Cellular Export Machinery"
XP_046413401.1	10	Reactome: R-HSA-167172;Reactome: R-HSA-167162;Reactome: R-HSA-6807505;Reactome: R-HSA-76042;Reactome: R-HSA-75953;Reactome: R-HSA-73779;Reactome: R-HSA-674695;Reactome: R-HSA-73776;Reactome: R-HSA-6804756;Reactome: R-HSA-167161	"Transcription of the HIV genome";"RNA Polymerase II HIV Promoter Escape";"RNA polymerase II transcribes snRNA genes";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Promoter Escape";"Regulation of TP53 Activity through Phosphorylation";"HIV Transcription Initiation"
XP_046418726.1	16	Reactome: R-HSA-1234176;Reactome: R-HSA-167287;Reactome: R-HSA-180585;Reactome: R-HSA-167238;Reactome: R-HSA-167246;Reactome: R-HSA-8951664;Reactome: R-HSA-167290;Reactome: R-HSA-167152;Reactome: R-HSA-674695;Reactome: R-HSA-167200;Reactome: R-HSA-6796648;Reactome: R-HSA-112382;Reactome: R-HSA-9010553;Reactome: R-HSA-167243;Reactome: R-HSA-983168;Reactome: R-HSA-75955	"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"HIV elongation arrest and recovery";"Vif-mediated degradation of APOBEC3G";"Pausing and recovery of Tat-mediated HIV elongation";"Tat-mediated elongation of the HIV-1 transcript";"Neddylation";"Pausing and recovery of HIV elongation";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Polymerase II Pre-transcription Events";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"TP53 Regulates Transcription of DNA Repair Genes";"Formation of RNA Pol II elongation complex";"Regulation of expression of SLITs and ROBOs";"Tat-mediated HIV elongation arrest and recovery";"Antigen processing: Ubiquitination & Proteasome degradation";"RNA Polymerase II Transcription Elongation"
XP_046416477.1	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
XP_046427242.1	8	MetaCyc: PWY-7193;Reactome: R-HSA-6798695;Reactome: R-HSA-73614;MetaCyc: PWY-7199;MetaCyc: PWY-6556;KEGG: 00240+3.5.4.5;KEGG: 00983+3.5.4.5;MetaCyc: PWY-7181	"Pyrimidine ribonucleosides salvage I";"Neutrophil degranulation";"Pyrimidine salvage";"Pyrimidine deoxyribonucleosides salvage";"Pyrimidine ribonucleosides salvage II";"Pyrimidine metabolism";"Drug metabolism - other enzymes";"Pyrimidine deoxyribonucleosides degradation"
XP_046432081.1	7	KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04926+2.7.11.1	"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Thermogenesis";"Human cytomegalovirus infection";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Relaxin signaling pathway"
XP_046415378.1	1	Reactome: R-HSA-111957	"Cam-PDE 1 activation"
XP_046415501.1	3	Reactome: R-HSA-6804757;Reactome: R-HSA-9609690;Reactome: R-HSA-3899300	"Regulation of TP53 Degradation";"HCMV Early Events";"SUMOylation of transcription cofactors"
XP_046418875.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_046412466.1	1	Reactome: R-HSA-110362	"POLB-Dependent Long Patch Base Excision Repair"
XP_046430767.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_046417161.1	56	Reactome: R-HSA-211733;Reactome: R-HSA-4641258;Reactome: R-HSA-5632684;Reactome: R-HSA-450408;Reactome: R-HSA-5610780;Reactome: R-HSA-1236974;Reactome: R-HSA-9010553;Reactome: R-HSA-350562;Reactome: R-HSA-8941858;Reactome: R-HSA-5668541;Reactome: R-HSA-5362768;Reactome: R-HSA-9604323;Reactome: R-HSA-5676590;Reactome: R-HSA-69601;Reactome: R-HSA-5358346;Reactome: R-HSA-69017;Reactome: R-HSA-195253;Reactome: R-HSA-2871837;Reactome: R-HSA-174178;Reactome: R-HSA-1169091;Reactome: R-HSA-382556;Reactome: R-HSA-68949;Reactome: R-HSA-9020702;Reactome: R-HSA-8854050;Reactome: R-HSA-5687128;Reactome: R-HSA-174113;Reactome: R-HSA-187577;Reactome: R-HSA-180534;Reactome: R-HSA-5607764;Reactome: R-HSA-68827;Reactome: R-HSA-5689603;Reactome: R-HSA-5610783;Reactome: R-HSA-8852276;Reactome: R-HSA-69481;Reactome: R-HSA-8948751;Reactome: R-HSA-1234176;Reactome: R-HSA-5658442;Reactome: R-HSA-983168;Reactome: R-HSA-5607761;Reactome: R-HSA-8939902;Reactome: R-HSA-174184;Reactome: R-HSA-174154;Reactome: R-HSA-2467813;Reactome: R-HSA-349425;Reactome: R-HSA-8951664;Reactome: R-HSA-174084;Reactome: R-HSA-5689880;Reactome: R-HSA-202424;Reactome: R-HSA-75815;Reactome: R-HSA-4608870;Reactome: R-HSA-4641257;Reactome: R-HSA-1236978;Reactome: R-HSA-5610785;Reactome: R-HSA-5678895;Reactome: R-HSA-180585;Reactome: R-HSA-8939236	"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Degradation of DVL";"Hedgehog 'on' state";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Degradation of GLI1 by the proteasome";"ER-Phagosome pathway";"Regulation of expression of SLITs and ROBOs";"Regulation of ornithine decarboxylase (ODC)";"Regulation of RUNX3 expression and activity";"TNFR2 non-canonical NF-kB pathway";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Negative regulation of NOTCH4 signaling";"NIK-->noncanonical NF-kB signaling";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Hedgehog ligand biogenesis";"CDK-mediated phosphorylation and removal of Cdc6";"Degradation of beta-catenin by the destruction complex";"FCERI mediated NF-kB activation";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Activation of NF-kappaB in B cells";"ABC-family proteins mediated transport";"Orc1 removal from chromatin";"Interleukin-1 signaling";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"MAPK6/MAPK4 signaling";"SCF-beta-TrCP mediated degradation of Emi1";"SCF(Skp2)-mediated degradation of p27/p21";"Vpu mediated degradation of CD4";"CLEC7A (Dectin-1) signaling";"CDT1 association with the CDC6:ORC:origin complex";"UCH proteinases";"Degradation of GLI2 by the proteasome";"The role of GTSE1 in G2/M progression after G2 checkpoint";"G2/M Checkpoints";"Regulation of PTEN stability and activity";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of RAS by GAPs";"Antigen processing: Ubiquitination & Proteasome degradation";"Dectin-1 mediated noncanonical NF-kB signaling";"Regulation of RUNX2 expression and activity";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"APC/C:Cdc20 mediated degradation of Securin";"Separation of Sister Chromatids";"Autodegradation of the E3 ubiquitin ligase COP1";"Neddylation";"Autodegradation of Cdh1 by Cdh1:APC/C";"Ub-specific processing proteases";"Downstream TCR signaling";"Ubiquitin-dependent degradation of Cyclin D";"Asymmetric localization of PCP proteins";"Degradation of AXIN";"Cross-presentation of soluble exogenous antigens (endosomes)";"GLI3 is processed to GLI3R by the proteasome";"Defective CFTR causes cystic fibrosis";"Vif-mediated degradation of APOBEC3G";"RUNX1 regulates transcription of genes involved in differentiation of HSCs"
XP_046435850.1	3	KEGG: 00240+1.3.5.2;MetaCyc: PWY-5686;Reactome: R-HSA-500753	"Pyrimidine metabolism";"UMP biosynthesis I";"Pyrimidine biosynthesis"
XP_046430863.1	1	Reactome: R-HSA-6809371	"Formation of the cornified envelope"
XP_046427756.1	1	Reactome: R-HSA-1614517	"Sulfide oxidation to sulfate"
XP_046420047.1	19	Reactome: R-HSA-9609736;Reactome: R-HSA-936837;Reactome: R-HSA-399719;Reactome: R-HSA-5578775;Reactome: R-HSA-111932;Reactome: R-HSA-9022692;Reactome: R-HSA-438066;Reactome: R-HSA-9617324;Reactome: R-HSA-5576892;Reactome: R-HSA-877300;Reactome: R-HSA-442982;Reactome: R-HSA-9649948;Reactome: R-HSA-6802952;Reactome: R-HSA-3371571;Reactome: R-HSA-6802955;Reactome: R-HSA-5673001;Reactome: R-HSA-9620244;Reactome: R-HSA-6802946;Reactome: R-HSA-5673000	"Assembly and cell surface presentation of NMDA receptors";"Ion transport by P-type ATPases";"Trafficking of AMPA receptors";"Ion homeostasis";"CaMK IV-mediated phosphorylation of CREB";"Regulation of MECP2 expression and activity";"Unblocking of NMDA receptors, glutamate binding and activation";"Negative regulation of NMDA receptor-mediated neuronal transmission";"Phase 0 - rapid depolarisation";"Interferon gamma signaling";"Ras activation upon Ca2+ influx through NMDA receptor";"Signaling downstream of RAS mutants";"Signaling by BRAF and RAF fusions";"HSF1-dependent transactivation";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"RAF/MAP kinase cascade";"Long-term potentiation";"Signaling by moderate kinase activity BRAF mutants";"RAF activation"
XP_046433827.1	7	KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1	"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Thermogenesis";"Human cytomegalovirus infection";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Relaxin signaling pathway"
XP_046424349.1	1	Reactome: R-HSA-499943	"Interconversion of nucleotide di- and triphosphates"
XP_046416608.1	5	MetaCyc: PWY-7918;Reactome: R-HSA-4793954;Reactome: R-HSA-532668;MetaCyc: PWY-7919;KEGG: 00510+3.2.1.106	"Protein N-glycosylation processing phase (yeast)";"Defective MOGS causes MOGS-CDG (CDG-2b)";"N-glycan trimming in the ER and Calnexin/Calreticulin cycle";"Protein N-glycosylation processing phase (plants and animals)";"N-Glycan biosynthesis"
XP_046415292.1	5	Reactome: R-HSA-5696400;Reactome: R-HSA-5685938;Reactome: R-HSA-6782135;Reactome: R-HSA-5696395;Reactome: R-HSA-6783310	"Dual Incision in GG-NER";"HDR through Single Strand Annealing (SSA)";"Dual incision in TC-NER";"Formation of Incision Complex in GG-NER";"Fanconi Anemia Pathway"
XP_046430373.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046421227.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_046420453.1	2	Reactome: R-HSA-2022377;Reactome: R-HSA-6798695	"Metabolism of Angiotensinogen to Angiotensins";"Neutrophil degranulation"
XP_046435390.1	2	Reactome: R-HSA-196783;KEGG: 00770+6.3.2.5	"Coenzyme A biosynthesis";"Pantothenate and CoA biosynthesis"
XP_046415182.1	2	Reactome: R-HSA-418890;Reactome: R-HSA-3295583	"Role of second messengers in netrin-1 signaling";"TRP channels"
XP_046422231.1	13	Reactome: R-HSA-156902;Reactome: R-HSA-975956;Reactome: R-HSA-72764;Reactome: R-HSA-975957;Reactome: R-HSA-6791226;Reactome: R-HSA-72706;Reactome: R-HSA-2408557;Reactome: R-HSA-1799339;Reactome: R-HSA-9633012;Reactome: R-HSA-72689;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-192823	"Peptide chain elongation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Selenocysteine synthesis";"SRP-dependent cotranslational protein targeting to membrane";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Formation of a pool of free 40S subunits";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Viral mRNA Translation"
XP_046429266.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046418417.1	2	Reactome: R-HSA-6783310;Reactome: R-HSA-6796648	"Fanconi Anemia Pathway";"TP53 Regulates Transcription of DNA Repair Genes"
XP_046428684.1	1	Reactome: R-HSA-432722	"Golgi Associated Vesicle Biogenesis"
XP_046435084.1	7	KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1	"Thermogenesis";"Human cytomegalovirus infection";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Relaxin signaling pathway";"mTOR signaling pathway";"PI3K-Akt signaling pathway"
XP_046433716.1	2	Reactome: R-HSA-8949664;Reactome: R-HSA-8949215	"Processing of SMDT1";"Mitochondrial calcium ion transport"
XP_046425834.1	1	Reactome: R-HSA-196836	"Vitamin C (ascorbate) metabolism"
XP_046424171.1	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
XP_046415270.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_046418723.1	16	Reactome: R-HSA-167243;Reactome: R-HSA-9010553;Reactome: R-HSA-112382;Reactome: R-HSA-75955;Reactome: R-HSA-983168;Reactome: R-HSA-167152;Reactome: R-HSA-167290;Reactome: R-HSA-6796648;Reactome: R-HSA-167200;Reactome: R-HSA-674695;Reactome: R-HSA-167238;Reactome: R-HSA-8951664;Reactome: R-HSA-167246;Reactome: R-HSA-1234176;Reactome: R-HSA-167287;Reactome: R-HSA-180585	"Tat-mediated HIV elongation arrest and recovery";"Regulation of expression of SLITs and ROBOs";"Formation of RNA Pol II elongation complex";"RNA Polymerase II Transcription Elongation";"Antigen processing: Ubiquitination & Proteasome degradation";"Formation of HIV elongation complex in the absence of HIV Tat";"Pausing and recovery of HIV elongation";"TP53 Regulates Transcription of DNA Repair Genes";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Polymerase II Pre-transcription Events";"Pausing and recovery of Tat-mediated HIV elongation";"Neddylation";"Tat-mediated elongation of the HIV-1 transcript";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"HIV elongation arrest and recovery";"Vif-mediated degradation of APOBEC3G"
XP_046415312.1	10	MetaCyc: PWY-7996;MetaCyc: PWY-5890;KEGG: 00130+2.1.1.163;MetaCyc: PWY-5891;MetaCyc: PWY-5839;MetaCyc: PWY-5895;MetaCyc: PWY-5892;MetaCyc: PWY-5849;MetaCyc: PWY-5844;Reactome: R-HSA-2142789	"Menaquinol-4 biosynthesis I";"Menaquinol-10 biosynthesis";"Ubiquinone and other terpenoid-quinone biosynthesis";"Menaquinol-11 biosynthesis";"Menaquinol-7 biosynthesis";"Menaquinol-13 biosynthesis";"Menaquinol-12 biosynthesis";"Menaquinol-6 biosynthesis";"Menaquinol-9 biosynthesis";"Ubiquinol biosynthesis"
XP_046432804.1	1	KEGG: 00480+3.4.11.1	"Glutathione metabolism"
XP_046425063.1	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
XP_046433132.1	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
XP_046426151.1	2	Reactome: R-HSA-5620924;Reactome: R-HSA-5610787	"Intraflagellar transport";"Hedgehog 'off' state"
XP_046417543.1	2	Reactome: R-HSA-936837;Reactome: R-HSA-6798695	"Ion transport by P-type ATPases";"Neutrophil degranulation"
XP_046422171.1	1	Reactome: R-HSA-5576886	"Phase 4 - resting membrane potential"
XP_046411887.1	1	Reactome: R-HSA-5221030	"TET1,2,3 and TDG demethylate DNA"
XP_046435092.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_046420372.1	3	Reactome: R-HSA-4420097;Reactome: R-HSA-5663213;Reactome: R-HSA-2029482	"VEGFA-VEGFR2 Pathway";"RHO GTPases Activate WASPs and WAVEs";"Regulation of actin dynamics for phagocytic cup formation"
XP_046409657.1	4	Reactome: R-HSA-112311;KEGG: 00564+3.1.1.7;Reactome: R-HSA-422085;Reactome: R-HSA-1483191	"Neurotransmitter clearance";"Glycerophospholipid metabolism";"Synthesis, secretion, and deacylation of Ghrelin";"Synthesis of PC"
XP_046424931.1	1	Reactome: R-HSA-432720	"Lysosome Vesicle Biogenesis"
XP_046424528.1	3	MetaCyc: PWY-7511;Reactome: R-HSA-983168;Reactome: R-HSA-6783310	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation";"Fanconi Anemia Pathway"
XP_046431863.1	14	Reactome: R-HSA-426486;Reactome: R-HSA-9018519;Reactome: R-HSA-8934593;Reactome: R-HSA-5628897;Reactome: R-HSA-8948700;Reactome: R-HSA-8986944;Reactome: R-HSA-4086398;Reactome: R-HSA-8943723;Reactome: R-HSA-1912408;Reactome: R-HSA-5687128;Reactome: R-HSA-203927;Reactome: R-HSA-9022692;Reactome: R-HSA-426496;Reactome: R-HSA-9029569	"Small interfering RNA (siRNA) biogenesis";"Estrogen-dependent gene expression";"Regulation of RUNX1 Expression and Activity";"TP53 Regulates Metabolic Genes";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"Transcriptional Regulation by MECP2";"Ca2+ pathway";"Regulation of PTEN mRNA translation";"Pre-NOTCH Transcription and Translation";"MAPK6/MAPK4 signaling";"MicroRNA (miRNA) biogenesis";"Regulation of MECP2 expression and activity";"Post-transcriptional silencing by small RNAs";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux"
XP_046433710.1	2	Reactome: R-HSA-379716;KEGG: 00970+6.1.1.1	"Cytosolic tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis"
XP_046435436.1	56	Reactome: R-HSA-180585;Reactome: R-HSA-5678895;Reactome: R-HSA-5610785;Reactome: R-HSA-8939236;Reactome: R-HSA-5689880;Reactome: R-HSA-174084;Reactome: R-HSA-8951664;Reactome: R-HSA-349425;Reactome: R-HSA-1236978;Reactome: R-HSA-75815;Reactome: R-HSA-202424;Reactome: R-HSA-4608870;Reactome: R-HSA-4641257;Reactome: R-HSA-174154;Reactome: R-HSA-8939902;Reactome: R-HSA-174184;Reactome: R-HSA-2467813;Reactome: R-HSA-5607761;Reactome: R-HSA-983168;Reactome: R-HSA-5658442;Reactome: R-HSA-68827;Reactome: R-HSA-5689603;Reactome: R-HSA-180534;Reactome: R-HSA-187577;Reactome: R-HSA-5607764;Reactome: R-HSA-69481;Reactome: R-HSA-1234176;Reactome: R-HSA-8948751;Reactome: R-HSA-5610783;Reactome: R-HSA-8852276;Reactome: R-HSA-8854050;Reactome: R-HSA-9020702;Reactome: R-HSA-174113;Reactome: R-HSA-5687128;Reactome: R-HSA-9604323;Reactome: R-HSA-5362768;Reactome: R-HSA-5676590;Reactome: R-HSA-5358346;Reactome: R-HSA-69601;Reactome: R-HSA-69017;Reactome: R-HSA-68949;Reactome: R-HSA-1169091;Reactome: R-HSA-382556;Reactome: R-HSA-195253;Reactome: R-HSA-2871837;Reactome: R-HSA-174178;Reactome: R-HSA-450408;Reactome: R-HSA-5610780;Reactome: R-HSA-1236974;Reactome: R-HSA-211733;Reactome: R-HSA-4641258;Reactome: R-HSA-5632684;Reactome: R-HSA-8941858;Reactome: R-HSA-350562;Reactome: R-HSA-9010553;Reactome: R-HSA-5668541	"Vif-mediated degradation of APOBEC3G";"Defective CFTR causes cystic fibrosis";"GLI3 is processed to GLI3R by the proteasome";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Ub-specific processing proteases";"Autodegradation of Cdh1 by Cdh1:APC/C";"Neddylation";"Autodegradation of the E3 ubiquitin ligase COP1";"Cross-presentation of soluble exogenous antigens (endosomes)";"Ubiquitin-dependent degradation of Cyclin D";"Downstream TCR signaling";"Asymmetric localization of PCP proteins";"Degradation of AXIN";"APC/C:Cdc20 mediated degradation of Securin";"Regulation of RUNX2 expression and activity";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Separation of Sister Chromatids";"Dectin-1 mediated noncanonical NF-kB signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Regulation of RAS by GAPs";"CDT1 association with the CDC6:ORC:origin complex";"UCH proteinases";"Vpu mediated degradation of CD4";"SCF(Skp2)-mediated degradation of p27/p21";"CLEC7A (Dectin-1) signaling";"G2/M Checkpoints";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of PTEN stability and activity";"Degradation of GLI2 by the proteasome";"The role of GTSE1 in G2/M progression after G2 checkpoint";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Interleukin-1 signaling";"SCF-beta-TrCP mediated degradation of Emi1";"MAPK6/MAPK4 signaling";"Negative regulation of NOTCH4 signaling";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"NIK-->noncanonical NF-kB signaling";"Hedgehog ligand biogenesis";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"CDK-mediated phosphorylation and removal of Cdc6";"Orc1 removal from chromatin";"Activation of NF-kappaB in B cells";"ABC-family proteins mediated transport";"Degradation of beta-catenin by the destruction complex";"FCERI mediated NF-kB activation";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Degradation of GLI1 by the proteasome";"ER-Phagosome pathway";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Degradation of DVL";"Hedgehog 'on' state";"Regulation of RUNX3 expression and activity";"Regulation of ornithine decarboxylase (ODC)";"Regulation of expression of SLITs and ROBOs";"TNFR2 non-canonical NF-kB pathway"
XP_046409976.1	2	Reactome: R-HSA-3214858;Reactome: R-HSA-8939243	"RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"
XP_046418340.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046435580.1	6	KEGG: 00052+2.7.7.12;Reactome: R-HSA-5609978;KEGG: 00520+2.7.7.12;MetaCyc: PWY-6527;MetaCyc: PWY-6317;Reactome: R-HSA-70370	"Galactose metabolism";"Defective GALT can cause Galactosemia";"Amino sugar and nucleotide sugar metabolism";"Stachyose degradation";"D-galactose degradation I (Leloir pathway)";"Galactose catabolism"
XP_046411292.1	2	Reactome: R-HSA-167827;Reactome: R-HSA-167826	"The proton buffering model";"The fatty acid cycling model"
XP_046421109.1	4	MetaCyc: PWY-7382;Reactome: R-HSA-389661;MetaCyc: PWY-6987;KEGG: 00785+2.3.1.181	"Lipoate biosynthesis and incorporation IV (yeast)";"Glyoxylate metabolism and glycine degradation";"Lipoate biosynthesis and incorporation III (Bacillus)";"Lipoic acid metabolism"
XP_046415103.1	11	MetaCyc: PWY-5695;Reactome: R-HSA-74259;MetaCyc: PWY-6538;MetaCyc: PWY-6607;Reactome: R-HSA-8851680;MetaCyc: PWY-6596;MetaCyc: PWY-6999;MetaCyc: PWY-6606;MetaCyc: PWY-6608;KEGG: 00230+1.17.1.4;MetaCyc: PWY-5497	"Inosine 5'-phosphate degradation";"Purine catabolism";"Caffeine degradation III (bacteria, via demethylation)";"Guanosine nucleotides degradation I";"Butyrophilin (BTN) family interactions";"Adenosine nucleotides degradation I";"Theophylline degradation";"Guanosine nucleotides degradation II";"Guanosine nucleotides degradation III";"Purine metabolism";"Purine nucleobases degradation II (anaerobic)"
XP_046410259.1	2	Reactome: R-HSA-5678895;Reactome: R-HSA-382556	"Defective CFTR causes cystic fibrosis";"ABC-family proteins mediated transport"
XP_046428817.1	1	Reactome: R-HSA-6799198	"Complex I biogenesis"
XP_046436460.1	6	KEGG: 04070+2.7.1.107;Reactome: R-HSA-114508;KEGG: 00564+2.7.1.107;MetaCyc: PWY-7817;MetaCyc: PWY-7039;KEGG: 00561+2.7.1.107	"Phosphatidylinositol signaling system";"Effects of PIP2 hydrolysis";"Glycerophospholipid metabolism";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Phosphatidate metabolism, as a signaling molecule";"Glycerolipid metabolism"
XP_046418897.1	1	Reactome: R-HSA-8964572	"Lipid particle organization"
XP_046411464.1	2	MetaCyc: PWY-7221;KEGG: 00230+2.7.4.8	"Guanosine ribonucleotides de novo biosynthesis";"Purine metabolism"
XP_046423347.1	2	Reactome: R-HSA-180024;KEGG: 00230+3.1.4.53	"DARPP-32 events";"Purine metabolism"
XP_046424518.1	1	Reactome: R-HSA-156842	"Eukaryotic Translation Elongation"
XP_046422994.1	1	Reactome: R-HSA-204005	"COPII-mediated vesicle transport"
XP_046419231.1	9	Reactome: R-HSA-438066;Reactome: R-HSA-9617324;Reactome: R-HSA-5673001;Reactome: R-HSA-3928662;Reactome: R-HSA-9620244;Reactome: R-HSA-9609736;Reactome: R-HSA-442982;Reactome: R-HSA-6794361;Reactome: R-HSA-8849932	"Unblocking of NMDA receptors, glutamate binding and activation";"Negative regulation of NMDA receptor-mediated neuronal transmission";"RAF/MAP kinase cascade";"EPHB-mediated forward signaling";"Long-term potentiation";"Assembly and cell surface presentation of NMDA receptors";"Ras activation upon Ca2+ influx through NMDA receptor";"Neurexins and neuroligins";"Synaptic adhesion-like molecules"
XP_046414962.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_046432587.1	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
XP_046416670.1	6	Reactome: R-HSA-8951430;Reactome: R-HSA-201722;Reactome: R-HSA-4641265;Reactome: R-HSA-3769402;Reactome: R-HSA-4086398;Reactome: R-HSA-4411364	"RUNX3 regulates WNT signaling";"Formation of the beta-catenin:TCF transactivating complex";"Repression of WNT target genes";"Deactivation of the beta-catenin transactivating complex";"Ca2+ pathway";"Binding of TCF/LEF:CTNNB1 to target gene promoters"
XP_046409495.1	6	Reactome: R-HSA-69052;Reactome: R-HSA-68949;Reactome: R-HSA-68962;Reactome: R-HSA-176187;Reactome: R-HSA-176974;Reactome: R-HSA-68867	"Switching of origins to a post-replicative state";"Orc1 removal from chromatin";"Activation of the pre-replicative complex";"Activation of ATR in response to replication stress";"Unwinding of DNA";"Assembly of the pre-replicative complex"
XP_046424000.1	1	Reactome: R-HSA-6794361	"Neurexins and neuroligins"
XP_046421995.1	2	Reactome: R-HSA-1296052;Reactome: R-HSA-418457	"Ca2+ activated K+ channels";"cGMP effects"
XP_046424045.1	14	Reactome: R-HSA-110312;Reactome: R-HSA-174411;Reactome: R-HSA-5651801;Reactome: R-HSA-6782135;Reactome: R-HSA-110320;Reactome: R-HSA-5696400;Reactome: R-HSA-5656169;Reactome: R-HSA-5655862;Reactome: R-HSA-6782210;Reactome: R-HSA-69091;Reactome: R-HSA-5685942;Reactome: R-HSA-110314;Reactome: R-HSA-5696397;Reactome: R-HSA-5656121	"Translesion synthesis by REV1";"Polymerase switching on the C-strand of the telomere";"PCNA-Dependent Long Patch Base Excision Repair";"Dual incision in TC-NER";"Translesion Synthesis by POLH";"Dual Incision in GG-NER";"Termination of translesion DNA synthesis";"Translesion synthesis by POLK";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Polymerase switching";"HDR through Homologous Recombination (HRR)";"Recognition of DNA damage by PCNA-containing replication complex";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Translesion synthesis by POLI"
XP_046424038.1	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
XP_046412457.1	2	Reactome: R-HSA-70895;KEGG: 00280+1.1.1.31	"Branched-chain amino acid catabolism";"Valine, leucine and isoleucine degradation"
XP_046420669.1	2	KEGG: 00030+2.7.6.1;KEGG: 00230+2.7.6.1	"Pentose phosphate pathway";"Purine metabolism"
XP_046422596.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046430870.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_046418752.1	14	KEGG: 00562+3.1.4.11;MetaCyc: PWY-7039;MetaCyc: PWY-6351;Reactome: R-HSA-434316;MetaCyc: PWY-8052;Reactome: R-HSA-418217;Reactome: R-HSA-399997;Reactome: R-HSA-4086398;Reactome: R-HSA-112043;MetaCyc: PWY-6367;Reactome: R-HSA-500657;KEGG: 04070+3.1.4.11;Reactome: R-HSA-416476;Reactome: R-HSA-1855204	"Inositol phosphate metabolism";"Phosphatidate metabolism, as a signaling molecule";"D-myo-inositol (1,4,5)-trisphosphate biosynthesis";"Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion";"2-arachidonoylglycerol biosynthesis";"G beta:gamma signalling through PLC beta";"Acetylcholine regulates insulin secretion";"Ca2+ pathway";"PLC beta mediated events";"D-myo-inositol-5-phosphate metabolism";"Presynaptic function of Kainate receptors";"Phosphatidylinositol signaling system";"G alpha (q) signalling events";"Synthesis of IP3 and IP4 in the cytosol"
XP_046433273.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046413289.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046424156.1	6	MetaCyc: PWY-7382;Reactome: R-HSA-3371599;KEGG: 00780+6.3.4.15;MetaCyc: PWY-6987;KEGG: 00785+2.3.1.181;Reactome: R-HSA-196780	"Lipoate biosynthesis and incorporation IV (yeast)";"Defective HLCS causes multiple carboxylase deficiency";"Biotin metabolism";"Lipoate biosynthesis and incorporation III (Bacillus)";"Lipoic acid metabolism";"Biotin transport and metabolism"
XP_046432881.1	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
XP_046428840.1	1	Reactome: R-HSA-6799198	"Complex I biogenesis"
XP_046410424.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_046424823.1	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276	"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination"
XP_046422295.1	2	Reactome: R-HSA-5678895;Reactome: R-HSA-382556	"Defective CFTR causes cystic fibrosis";"ABC-family proteins mediated transport"
XP_046434869.1	1	Reactome: R-HSA-1445148	"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
XP_046415195.1	2	KEGG: 00230+2.7.4.8;MetaCyc: PWY-7221	"Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis"
XP_046421621.1	3	Reactome: R-HSA-1855167;MetaCyc: PWY-6369;KEGG: 04070+2.7.4.24+2.7.4.21	"Synthesis of pyrophosphates in the cytosol";"Inositol diphosphates biosynthesis";"Phosphatidylinositol signaling system"
XP_046427172.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046423145.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_046410165.1	1	Reactome: R-HSA-77289	"Mitochondrial Fatty Acid Beta-Oxidation"
XP_046422174.1	2	Reactome: R-HSA-379716;KEGG: 00970+6.1.1.21	"Cytosolic tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis"
XP_046424598.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046425055.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_046411760.1	4	Reactome: R-HSA-983712;Reactome: R-HSA-917977;Reactome: R-HSA-77387;Reactome: R-HSA-1222556	"Ion channel transport";"Transferrin endocytosis and recycling";"Insulin receptor recycling";"ROS and RNS production in phagocytes"
XP_046426932.1	6	MetaCyc: PWY-5497;MetaCyc: PWY-6608;MetaCyc: PWY-6606;KEGG: 00230+3.5.4.3;MetaCyc: PWY-7442;Reactome: R-HSA-74259	"Purine nucleobases degradation II (anaerobic)";"Guanosine nucleotides degradation III";"Guanosine nucleotides degradation II";"Purine metabolism";"Drosopterin and aurodrosopterin biosynthesis";"Purine catabolism"
XP_046436632.1	2	Reactome: R-HSA-4086398;Reactome: R-HSA-418457	"Ca2+ pathway";"cGMP effects"
XP_046414412.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046410689.1	1	Reactome: R-HSA-5689603	"UCH proteinases"
XP_046424915.1	3	MetaCyc: PWY-7511;Reactome: R-HSA-983168;Reactome: R-HSA-6798695	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation";"Neutrophil degranulation"
XP_046413771.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
XP_046429420.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046418580.1	5	Reactome: R-HSA-1222556;Reactome: R-HSA-77387;Reactome: R-HSA-917977;Reactome: R-HSA-9639288;Reactome: R-HSA-983712	"ROS and RNS production in phagocytes";"Insulin receptor recycling";"Transferrin endocytosis and recycling";"Amino acids regulate mTORC1";"Ion channel transport"
XP_046409977.1	2	Reactome: R-HSA-8939243;Reactome: R-HSA-3214858	"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RMTs methylate histone arginines"
XP_046418628.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046409808.1	1	Reactome: R-HSA-425381	"Bicarbonate transporters"
XP_046410597.1	1	Reactome: R-HSA-6799198	"Complex I biogenesis"
XP_046416065.1	57	Reactome: R-HSA-195253;Reactome: R-HSA-2871837;Reactome: R-HSA-174178;Reactome: R-HSA-68949;Reactome: R-HSA-382556;Reactome: R-HSA-1169091;Reactome: R-HSA-5362768;Reactome: R-HSA-5676590;Reactome: R-HSA-9604323;Reactome: R-HSA-69017;Reactome: R-HSA-69601;Reactome: R-HSA-5358346;Reactome: R-HSA-8941858;Reactome: R-HSA-350562;Reactome: R-HSA-9010553;Reactome: R-HSA-5668541;Reactome: R-HSA-211733;Reactome: R-HSA-4641258;Reactome: R-HSA-5632684;Reactome: R-HSA-450408;Reactome: R-HSA-5610780;Reactome: R-HSA-1236974;Reactome: R-HSA-5610783;Reactome: R-HSA-8852276;Reactome: R-HSA-69481;Reactome: R-HSA-8948751;Reactome: R-HSA-1234176;Reactome: R-HSA-180534;Reactome: R-HSA-187577;Reactome: R-HSA-5607764;Reactome: R-HSA-68827;Reactome: R-HSA-5689603;Reactome: R-HSA-5687128;Reactome: R-HSA-174113;Reactome: R-HSA-8854050;Reactome: R-HSA-9020702;Reactome: R-HSA-2467813;Reactome: R-HSA-8939902;Reactome: R-HSA-174184;Reactome: R-HSA-174154;Reactome: R-HSA-6798695;Reactome: R-HSA-983168;Reactome: R-HSA-5658442;Reactome: R-HSA-5607761;Reactome: R-HSA-8939236;Reactome: R-HSA-5610785;Reactome: R-HSA-180585;Reactome: R-HSA-5678895;Reactome: R-HSA-202424;Reactome: R-HSA-75815;Reactome: R-HSA-4608870;Reactome: R-HSA-4641257;Reactome: R-HSA-1236978;Reactome: R-HSA-349425;Reactome: R-HSA-174084;Reactome: R-HSA-8951664;Reactome: R-HSA-5689880	"Degradation of beta-catenin by the destruction complex";"FCERI mediated NF-kB activation";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Orc1 removal from chromatin";"ABC-family proteins mediated transport";"Activation of NF-kappaB in B cells";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"NIK-->noncanonical NF-kB signaling";"Negative regulation of NOTCH4 signaling";"CDK-mediated phosphorylation and removal of Cdc6";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Hedgehog ligand biogenesis";"Regulation of RUNX3 expression and activity";"Regulation of ornithine decarboxylase (ODC)";"Regulation of expression of SLITs and ROBOs";"TNFR2 non-canonical NF-kB pathway";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Degradation of DVL";"Hedgehog 'on' state";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Degradation of GLI1 by the proteasome";"ER-Phagosome pathway";"Degradation of GLI2 by the proteasome";"The role of GTSE1 in G2/M progression after G2 checkpoint";"G2/M Checkpoints";"Regulation of PTEN stability and activity";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Vpu mediated degradation of CD4";"SCF(Skp2)-mediated degradation of p27/p21";"CLEC7A (Dectin-1) signaling";"CDT1 association with the CDC6:ORC:origin complex";"UCH proteinases";"MAPK6/MAPK4 signaling";"SCF-beta-TrCP mediated degradation of Emi1";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Interleukin-1 signaling";"Separation of Sister Chromatids";"Regulation of RUNX2 expression and activity";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"APC/C:Cdc20 mediated degradation of Securin";"Neutrophil degranulation";"Antigen processing: Ubiquitination & Proteasome degradation";"Regulation of RAS by GAPs";"Dectin-1 mediated noncanonical NF-kB signaling";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"GLI3 is processed to GLI3R by the proteasome";"Vif-mediated degradation of APOBEC3G";"Defective CFTR causes cystic fibrosis";"Downstream TCR signaling";"Ubiquitin-dependent degradation of Cyclin D";"Asymmetric localization of PCP proteins";"Degradation of AXIN";"Cross-presentation of soluble exogenous antigens (endosomes)";"Autodegradation of the E3 ubiquitin ligase COP1";"Autodegradation of Cdh1 by Cdh1:APC/C";"Neddylation";"Ub-specific processing proteases"
XP_046435459.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046428508.1	1	Reactome: R-HSA-1799339	"SRP-dependent cotranslational protein targeting to membrane"
XP_046434650.1	1	Reactome: R-HSA-209968	"Thyroxine biosynthesis"
XP_046426744.1	3	Reactome: R-HSA-8951664;MetaCyc: PWY-7511;Reactome: R-HSA-349425	"Neddylation";"Protein ubiquitination";"Autodegradation of the E3 ubiquitin ligase COP1"
XP_046418383.1	6	Reactome: R-HSA-5654700;Reactome: R-HSA-9028731;Reactome: R-HSA-5654706;Reactome: R-HSA-5654693;Reactome: R-HSA-5673001;Reactome: R-HSA-5654712	"FRS-mediated FGFR2 signaling";"Activated NTRK2 signals through FRS2 and FRS3";"FRS-mediated FGFR3 signaling";"FRS-mediated FGFR1 signaling";"RAF/MAP kinase cascade";"FRS-mediated FGFR4 signaling"
XP_046424597.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046410381.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_046432026.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_046417901.1	1	Reactome: R-HSA-6784531	"tRNA processing in the nucleus"
XP_046414698.1	2	Reactome: R-HSA-418594;Reactome: R-HSA-375276	"G alpha (i) signalling events";"Peptide ligand-binding receptors"
XP_046425410.1	2	Reactome: R-HSA-8856825;Reactome: R-HSA-8856828	"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis"
XP_046420239.1	15	Reactome: R-HSA-5467333;Reactome: R-HSA-5358751;Reactome: R-HSA-195253;Reactome: R-HSA-5358752;Reactome: R-HSA-3769402;Reactome: R-HSA-5358747;Reactome: R-HSA-111465;Reactome: R-HSA-4641262;Reactome: R-HSA-5339716;Reactome: R-HSA-5467340;Reactome: R-HSA-196299;Reactome: R-HSA-5689896;Reactome: R-HSA-5358749;Reactome: R-HSA-5467337;Reactome: R-HSA-5467348	"APC truncation mutants are not K63 polyubiquitinated";"S45 mutants of beta-catenin aren't phosphorylated";"Degradation of beta-catenin by the destruction complex";"T41 mutants of beta-catenin aren't phosphorylated";"Deactivation of the beta-catenin transactivating complex";"S33 mutants of beta-catenin aren't phosphorylated";"Apoptotic cleavage of cellular proteins";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"Misspliced GSK3beta mutants stabilize beta-catenin";"AXIN missense mutants destabilize the destruction complex";"Beta-catenin phosphorylation cascade";"Ovarian tumor domain proteases";"S37 mutants of beta-catenin aren't phosphorylated";"APC truncation mutants have impaired AXIN binding";"Truncations of AMER1 destabilize the destruction complex"
XP_046436447.1	5	Reactome: R-HSA-450321;Reactome: R-HSA-450341;Reactome: R-HSA-2559580;KEGG: 04150+2.7.11.24;Reactome: R-HSA-2871796	"JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1";"Activation of the AP-1 family of transcription factors";"Oxidative Stress Induced Senescence";"mTOR signaling pathway";"FCERI mediated MAPK activation"
XP_046433813.1	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
XP_046426504.1	7	KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1	"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Relaxin signaling pathway";"Thermogenesis";"Human cytomegalovirus infection";"mTOR signaling pathway";"PI3K-Akt signaling pathway"
XP_046420378.1	3	Reactome: R-HSA-5663213;Reactome: R-HSA-2029482;Reactome: R-HSA-4420097	"RHO GTPases Activate WASPs and WAVEs";"Regulation of actin dynamics for phagocytic cup formation";"VEGFA-VEGFR2 Pathway"
XP_046429514.1	1	Reactome: R-HSA-419771	"Opsins"
XP_046409959.1	2	Reactome: R-HSA-8876198;Reactome: R-HSA-204005	"RAB GEFs exchange GTP for GDP on RABs";"COPII-mediated vesicle transport"
XP_046433630.1	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_046428716.1	6	KEGG: 00564+2.7.1.107;Reactome: R-HSA-114508;KEGG: 04070+2.7.1.107;MetaCyc: PWY-7039;KEGG: 00561+2.7.1.107;MetaCyc: PWY-7817	"Glycerophospholipid metabolism";"Effects of PIP2 hydrolysis";"Phosphatidylinositol signaling system";"Phosphatidate metabolism, as a signaling molecule";"Glycerolipid metabolism";"Type I lipoteichoic acid biosynthesis (S. aureus)"
XP_046422085.1	3	Reactome: R-HSA-5663213;Reactome: R-HSA-2029482;Reactome: R-HSA-4420097	"RHO GTPases Activate WASPs and WAVEs";"Regulation of actin dynamics for phagocytic cup formation";"VEGFA-VEGFR2 Pathway"
XP_046423399.1	2	KEGG: 00563+2.4.1.198;Reactome: R-HSA-162710	"Glycosylphosphatidylinositol (GPI)-anchor biosynthesis";"Synthesis of glycosylphosphatidylinositol (GPI)"
XP_046421969.1	2	Reactome: R-HSA-1296052;Reactome: R-HSA-418457	"Ca2+ activated K+ channels";"cGMP effects"
XP_046423853.1	1	Reactome: R-HSA-71384	"Ethanol oxidation"
XP_046421060.1	4	Reactome: R-HSA-6811434;Reactome: R-HSA-2132295;Reactome: R-HSA-983189;Reactome: R-HSA-5625970	"COPI-dependent Golgi-to-ER retrograde traffic";"MHC class II antigen presentation";"Kinesins";"RHO GTPases activate KTN1"
XP_046423240.1	10	Reactome: R-HSA-69473;Reactome: R-HSA-6804756;Reactome: R-HSA-5693554;Reactome: R-HSA-5693616;Reactome: R-HSA-5685938;Reactome: R-HSA-5693568;Reactome: R-HSA-5693607;Reactome: R-HSA-912446;Reactome: R-HSA-5685942;Reactome: R-HSA-5693579	"G2/M DNA damage checkpoint";"Regulation of TP53 Activity through Phosphorylation";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Presynaptic phase of homologous DNA pairing and strand exchange";"HDR through Single Strand Annealing (SSA)";"Resolution of D-loop Structures through Holliday Junction Intermediates";"Processing of DNA double-strand break ends";"Meiotic recombination";"HDR through Homologous Recombination (HRR)";"Homologous DNA Pairing and Strand Exchange"
XP_046409677.1	5	Reactome: R-HSA-1222556;Reactome: R-HSA-77387;Reactome: R-HSA-9639288;Reactome: R-HSA-917977;Reactome: R-HSA-983712	"ROS and RNS production in phagocytes";"Insulin receptor recycling";"Amino acids regulate mTORC1";"Transferrin endocytosis and recycling";"Ion channel transport"
XP_046433147.1	1	Reactome: R-HSA-1632852	"Macroautophagy"
XP_046423762.1	8	Reactome: R-HSA-68962;Reactome: R-HSA-68949;Reactome: R-HSA-68827;Reactome: R-HSA-176187;Reactome: R-HSA-68616;Reactome: R-HSA-113507;Reactome: R-HSA-68689;Reactome: R-HSA-68867	"Activation of the pre-replicative complex";"Orc1 removal from chromatin";"CDT1 association with the CDC6:ORC:origin complex";"Activation of ATR in response to replication stress";"Assembly of the ORC complex at the origin of replication";"E2F-enabled inhibition of pre-replication complex formation";"CDC6 association with the ORC:origin complex";"Assembly of the pre-replicative complex"
XP_046425352.1	5	MetaCyc: PWY-7536;KEGG: 00860+2.3.1.37;Reactome: R-HSA-189451;KEGG: 00260+2.3.1.37;MetaCyc: PWY-5189	"2-amino-3-hydroxycyclopent-2-enone biosynthesis";"Porphyrin and chlorophyll metabolism";"Heme biosynthesis";"Glycine, serine and threonine metabolism";"Tetrapyrrole biosynthesis II (from glycine)"
XP_046431530.1	57	Reactome: R-HSA-8854050;Reactome: R-HSA-9020702;Reactome: R-HSA-5687128;Reactome: R-HSA-174113;Reactome: R-HSA-5607764;Reactome: R-HSA-180534;Reactome: R-HSA-187577;Reactome: R-HSA-5689603;Reactome: R-HSA-68827;Reactome: R-HSA-8852276;Reactome: R-HSA-5610783;Reactome: R-HSA-1234176;Reactome: R-HSA-8948751;Reactome: R-HSA-69481;Reactome: R-HSA-5632684;Reactome: R-HSA-211733;Reactome: R-HSA-4641258;Reactome: R-HSA-1236974;Reactome: R-HSA-450408;Reactome: R-HSA-5610780;Reactome: R-HSA-5668541;Reactome: R-HSA-9010553;Reactome: R-HSA-350562;Reactome: R-HSA-8941858;Reactome: R-HSA-69601;Reactome: R-HSA-5358346;Reactome: R-HSA-69017;Reactome: R-HSA-9604323;Reactome: R-HSA-5676590;Reactome: R-HSA-5362768;Reactome: R-HSA-174178;Reactome: R-HSA-2871837;Reactome: R-HSA-195253;Reactome: R-HSA-382556;Reactome: R-HSA-1169091;Reactome: R-HSA-68949;Reactome: R-HSA-349425;Reactome: R-HSA-5689880;Reactome: R-HSA-174084;Reactome: R-HSA-8951664;Reactome: R-HSA-4608870;Reactome: R-HSA-4641257;Reactome: R-HSA-75815;Reactome: R-HSA-202424;Reactome: R-HSA-1236978;Reactome: R-HSA-5610785;Reactome: R-HSA-5678895;Reactome: R-HSA-180585;Reactome: R-HSA-8939236;Reactome: R-HSA-5658442;Reactome: R-HSA-983168;Reactome: R-HSA-5607761;Reactome: R-HSA-6798695;Reactome: R-HSA-174184;Reactome: R-HSA-8939902;Reactome: R-HSA-174154;Reactome: R-HSA-2467813	"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Interleukin-1 signaling";"MAPK6/MAPK4 signaling";"SCF-beta-TrCP mediated degradation of Emi1";"CLEC7A (Dectin-1) signaling";"Vpu mediated degradation of CD4";"SCF(Skp2)-mediated degradation of p27/p21";"UCH proteinases";"CDT1 association with the CDC6:ORC:origin complex";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Degradation of GLI2 by the proteasome";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of PTEN stability and activity";"G2/M Checkpoints";"Hedgehog 'on' state";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Degradation of DVL";"ER-Phagosome pathway";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Degradation of GLI1 by the proteasome";"TNFR2 non-canonical NF-kB pathway";"Regulation of expression of SLITs and ROBOs";"Regulation of ornithine decarboxylase (ODC)";"Regulation of RUNX3 expression and activity";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Hedgehog ligand biogenesis";"CDK-mediated phosphorylation and removal of Cdc6";"Negative regulation of NOTCH4 signaling";"NIK-->noncanonical NF-kB signaling";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"FCERI mediated NF-kB activation";"Degradation of beta-catenin by the destruction complex";"ABC-family proteins mediated transport";"Activation of NF-kappaB in B cells";"Orc1 removal from chromatin";"Autodegradation of the E3 ubiquitin ligase COP1";"Ub-specific processing proteases";"Autodegradation of Cdh1 by Cdh1:APC/C";"Neddylation";"Asymmetric localization of PCP proteins";"Degradation of AXIN";"Ubiquitin-dependent degradation of Cyclin D";"Downstream TCR signaling";"Cross-presentation of soluble exogenous antigens (endosomes)";"GLI3 is processed to GLI3R by the proteasome";"Defective CFTR causes cystic fibrosis";"Vif-mediated degradation of APOBEC3G";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Regulation of RAS by GAPs";"Antigen processing: Ubiquitination & Proteasome degradation";"Dectin-1 mediated noncanonical NF-kB signaling";"Neutrophil degranulation";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Regulation of RUNX2 expression and activity";"APC/C:Cdc20 mediated degradation of Securin";"Separation of Sister Chromatids"
XP_046423219.1	1	KEGG: 04660+2.7.10.2	"T cell receptor signaling pathway"
XP_046409302.1	3	MetaCyc: PWY-6619;Reactome: R-HSA-74217;KEGG: 00230+2.7.1.20	"Adenine and adenosine salvage VI";"Purine salvage";"Purine metabolism"
XP_046427764.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_046410070.1	3	Reactome: R-HSA-8866654;Reactome: R-HSA-9603798;Reactome: R-HSA-9033241	"E3 ubiquitin ligases ubiquitinate target proteins";"Class I peroxisomal membrane protein import";"Peroxisomal protein import"
XP_046434503.1	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
XP_046417793.1	1	Reactome: R-HSA-2022377	"Metabolism of Angiotensinogen to Angiotensins"
XP_046416863.1	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
XP_046415937.1	1	Reactome: R-HSA-5620912	"Anchoring of the basal body to the plasma membrane"
XP_046417510.1	1	Reactome: R-HSA-5576886	"Phase 4 - resting membrane potential"
XP_046418281.1	5	Reactome: R-HSA-75896;Reactome: R-HSA-9033500;MetaCyc: PWY-7782;Reactome: R-HSA-9033241;KEGG: 00565+2.5.1.26	"Plasmalogen biosynthesis";"TYSND1 cleaves peroxisomal proteins";"Plasmalogen biosynthesis";"Peroxisomal protein import";"Ether lipid metabolism"
XP_046410175.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_046424323.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046417636.1	2	Reactome: R-HSA-416476;Reactome: R-HSA-375281	"G alpha (q) signalling events";"Hormone ligand-binding receptors"
XP_046428502.1	5	MetaCyc: PWY-3341;Reactome: R-HSA-8964539;KEGG: 00330+1.5.1.2;MetaCyc: PWY-4981;MetaCyc: PWY-6344	"L-proline biosynthesis III (from L-ornithine)";"Glutamate and glutamine metabolism";"Arginine and proline metabolism";"L-proline biosynthesis II (from arginine)";"L-ornithine degradation II (Stickland reaction)"
XP_046429532.1	2	Reactome: R-HSA-5357905;Reactome: R-HSA-8876198	"Regulation of TNFR1 signaling";"RAB GEFs exchange GTP for GDP on RABs"
XP_046432087.1	7	KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1	"Human cytomegalovirus infection";"Thermogenesis";"Relaxin signaling pathway";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"mTOR signaling pathway"
XP_046435756.1	5	MetaCyc: PWY-3341;Reactome: R-HSA-8964539;MetaCyc: PWY-6344;MetaCyc: PWY-4981;KEGG: 00330+1.5.1.2	"L-proline biosynthesis III (from L-ornithine)";"Glutamate and glutamine metabolism";"L-ornithine degradation II (Stickland reaction)";"L-proline biosynthesis II (from arginine)";"Arginine and proline metabolism"
XP_046421981.1	2	Reactome: R-HSA-418457;Reactome: R-HSA-1296052	"cGMP effects";"Ca2+ activated K+ channels"
XP_046411371.1	5	MetaCyc: PWY-5083;Reactome: R-HSA-196807;MetaCyc: PWY-7268;MetaCyc: PWY-7269;KEGG: 00760+2.7.1.23	"NAD/NADH phosphorylation and dephosphorylation";"Nicotinate metabolism";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)";"Nicotinate and nicotinamide metabolism"
XP_046433558.1	3	Reactome: R-HSA-983168;Reactome: R-HSA-1358803;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Downregulation of ERBB2:ERBB3 signaling";"Protein ubiquitination"
XP_046430125.1	4	MetaCyc: PWY-6987;KEGG: 00785+2.8.1.8;Reactome: R-HSA-389661;MetaCyc: PWY-7382	"Lipoate biosynthesis and incorporation III (Bacillus)";"Lipoic acid metabolism";"Glyoxylate metabolism and glycine degradation";"Lipoate biosynthesis and incorporation IV (yeast)"
XP_046424408.1	4	Reactome: R-HSA-351202;KEGG: 00330+2.5.1.16;KEGG: 00480+2.5.1.16;KEGG: 00270+2.5.1.16	"Metabolism of polyamines";"Arginine and proline metabolism";"Glutathione metabolism";"Cysteine and methionine metabolism"
XP_046436684.1	12	Reactome: R-HSA-5663220;Reactome: R-HSA-2500257;Reactome: R-HSA-6807878;Reactome: R-HSA-3371497;Reactome: R-HSA-2132295;Reactome: R-HSA-9609690;Reactome: R-HSA-68877;Reactome: R-HSA-9646399;Reactome: R-HSA-2467813;Reactome: R-HSA-6811436;Reactome: R-HSA-9648025;Reactome: R-HSA-141444	"RHO GTPases Activate Formins";"Resolution of Sister Chromatid Cohesion";"COPI-mediated anterograde transport";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"MHC class II antigen presentation";"HCMV Early Events";"Mitotic Prometaphase";"Aggrephagy";"Separation of Sister Chromatids";"COPI-independent Golgi-to-ER retrograde traffic";"EML4 and NUDC in mitotic spindle formation";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"
XP_046414748.1	1	Reactome: R-HSA-425986	"Sodium/Proton exchangers"
XP_046422074.1	2	Reactome: R-HSA-5223345;Reactome: R-HSA-425393	"Miscellaneous transport and binding events";"Transport of inorganic cations/anions and amino acids/oligopeptides"
XP_046417821.1	7	MetaCyc: PWY-2301;MetaCyc: PWY-4702;KEGG: 00521+3.1.3.25;MetaCyc: PWY-6363;KEGG: 00562+3.1.3.25;Reactome: R-HSA-1855183;KEGG: 04070+3.1.3.25	"Myo-inositol biosynthesis";"Phytate degradation I";"Streptomycin biosynthesis";"D-myo-inositol (1,4,5)-trisphosphate degradation";"Inositol phosphate metabolism";"Synthesis of IP2, IP, and Ins in the cytosol";"Phosphatidylinositol signaling system"
XP_046425779.1	2	Reactome: R-HSA-3299685;MetaCyc: PWY-6854	"Detoxification of Reactive Oxygen Species";"Ethylene biosynthesis III (microbes)"
XP_046434725.1	3	Reactome: R-HSA-5656169;Reactome: R-HSA-110320;Reactome: R-HSA-5685942	"Termination of translesion DNA synthesis";"Translesion Synthesis by POLH";"HDR through Homologous Recombination (HRR)"
XP_046435799.1	1	Reactome: R-HSA-196843	"Vitamin B2 (riboflavin) metabolism"
XP_046430470.1	4	Reactome: R-HSA-201722;Reactome: R-HSA-2122947;Reactome: R-HSA-4641265;Reactome: R-HSA-3769402	"Formation of the beta-catenin:TCF transactivating complex";"NOTCH1 Intracellular Domain Regulates Transcription";"Repression of WNT target genes";"Deactivation of the beta-catenin transactivating complex"
XP_046423596.1	6	MetaCyc: PWY-6363;KEGG: 04070+3.1.3.56;KEGG: 00562+3.1.3.56;Reactome: R-HSA-1855183;MetaCyc: PWY-6362;MetaCyc: PWY-6364	"D-myo-inositol (1,4,5)-trisphosphate degradation";"Phosphatidylinositol signaling system";"Inositol phosphate metabolism";"Synthesis of IP2, IP, and Ins in the cytosol";"1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)";"D-myo-inositol (1,3,4)-trisphosphate biosynthesis"
XP_046436733.1	3	Reactome: R-HSA-3899300;Reactome: R-HSA-3232118;Reactome: R-HSA-4090294	"SUMOylation of transcription cofactors";"SUMOylation of transcription factors";"SUMOylation of intracellular receptors"
XP_046427907.1	6	KEGG: 00564+2.7.1.107;Reactome: R-HSA-114508;KEGG: 04070+2.7.1.107;KEGG: 00561+2.7.1.107;MetaCyc: PWY-7039;MetaCyc: PWY-7817	"Glycerophospholipid metabolism";"Effects of PIP2 hydrolysis";"Phosphatidylinositol signaling system";"Glycerolipid metabolism";"Phosphatidate metabolism, as a signaling molecule";"Type I lipoteichoic acid biosynthesis (S. aureus)"
XP_046421987.1	2	Reactome: R-HSA-1296052;Reactome: R-HSA-418457	"Ca2+ activated K+ channels";"cGMP effects"
XP_046430855.1	3	Reactome: R-HSA-392154;KEGG: 00230+4.6.1.2;Reactome: R-HSA-445355	"Nitric oxide stimulates guanylate cyclase";"Purine metabolism";"Smooth Muscle Contraction"
XP_046422634.1	2	Reactome: R-HSA-5696394;Reactome: R-HSA-5689603	"DNA Damage Recognition in GG-NER";"UCH proteinases"
XP_046426581.1	2	Reactome: R-HSA-1296072;Reactome: R-HSA-5576894	"Voltage gated Potassium channels";"Phase 1 - inactivation of fast Na+ channels"
XP_046419740.1	5	KEGG: 00670+1.5.1.20;MetaCyc: PWY-2201;MetaCyc: PWY-3841;KEGG: 00720+1.5.1.20;Reactome: R-HSA-196757	"One carbon pool by folate";"Folate transformations I";"Folate transformations II (plants)";"Carbon fixation pathways in prokaryotes";"Metabolism of folate and pterines"
XP_046415992.1	1	Reactome: R-HSA-70895	"Branched-chain amino acid catabolism"
XP_046424096.1	24	Reactome: R-HSA-392451;Reactome: R-HSA-202040;Reactome: R-HSA-418594;Reactome: R-HSA-456926;Reactome: R-HSA-392170;Reactome: R-HSA-8964616;Reactome: R-HSA-9009391;Reactome: R-HSA-4086398;Reactome: R-HSA-163359;Reactome: R-HSA-418217;Reactome: R-HSA-6814122;Reactome: R-HSA-432040;Reactome: R-HSA-8964315;Reactome: R-HSA-420092;Reactome: R-HSA-381676;Reactome: R-HSA-428930;Reactome: R-HSA-416482;Reactome: R-HSA-418592;Reactome: R-HSA-416476;Reactome: R-HSA-418597;Reactome: R-HSA-500657;Reactome: R-HSA-400042;Reactome: R-HSA-392851;Reactome: R-HSA-418555	"G beta:gamma signalling through PI3Kgamma";"G-protein activation";"G alpha (i) signalling events";"Thrombin signalling through proteinase activated receptors (PARs)";"ADP signalling through P2Y purinoceptor 12";"G beta:gamma signalling through CDC42";"Extra-nuclear estrogen signaling";"Ca2+ pathway";"Glucagon signaling in metabolic regulation";"G beta:gamma signalling through PLC beta";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"Vasopressin regulates renal water homeostasis via Aquaporins";"G beta:gamma signalling through BTK";"Glucagon-type ligand receptors";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"Thromboxane signalling through TP receptor";"G alpha (12/13) signalling events";"ADP signalling through P2Y purinoceptor 1";"G alpha (q) signalling events";"G alpha (z) signalling events";"Presynaptic function of Kainate receptors";"Adrenaline,noradrenaline inhibits insulin secretion";"Prostacyclin signalling through prostacyclin receptor";"G alpha (s) signalling events"
XP_046422081.1	3	Reactome: R-HSA-193648;Reactome: R-HSA-194840;Reactome: R-HSA-416482	"NRAGE signals death through JNK";"Rho GTPase cycle";"G alpha (12/13) signalling events"
XP_046412664.1	17	Reactome: R-HSA-72706;Reactome: R-HSA-2408557;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-975956;Reactome: R-HSA-72702;Reactome: R-HSA-6791226;Reactome: R-HSA-6790901;Reactome: R-HSA-1799339;Reactome: R-HSA-72695;Reactome: R-HSA-192823;Reactome: R-HSA-72689;Reactome: R-HSA-72649;Reactome: R-HSA-72764;Reactome: R-HSA-156902;Reactome: R-HSA-975957	"GTP hydrolysis and joining of the 60S ribosomal subunit";"Selenocysteine synthesis";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Ribosomal scanning and start codon recognition";"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol";"SRP-dependent cotranslational protein targeting to membrane";"Formation of the ternary complex, and subsequently, the 43S complex";"Viral mRNA Translation";"Formation of a pool of free 40S subunits";"Translation initiation complex formation";"Eukaryotic Translation Termination";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
XP_046412175.1	4	KEGG: 00983+2.7.1.48;Reactome: R-HSA-73614;KEGG: 00240+2.7.1.48;MetaCyc: PWY-7193	"Drug metabolism - other enzymes";"Pyrimidine salvage";"Pyrimidine metabolism";"Pyrimidine ribonucleosides salvage I"
XP_046417602.1	2	Reactome: R-HSA-416476;Reactome: R-HSA-375281	"G alpha (q) signalling events";"Hormone ligand-binding receptors"
XP_046421611.1	3	Reactome: R-HSA-1855167;MetaCyc: PWY-6369;KEGG: 04070+2.7.4.24+2.7.4.21	"Synthesis of pyrophosphates in the cytosol";"Inositol diphosphates biosynthesis";"Phosphatidylinositol signaling system"
XP_046421219.1	3	Reactome: R-HSA-5620916;Reactome: R-HSA-264876;Reactome: R-HSA-1445148	"VxPx cargo-targeting to cilium";"Insulin processing";"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
XP_046424648.1	1	Reactome: R-HSA-6787450	"tRNA modification in the mitochondrion"
XP_046428265.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_046413375.1	7	Reactome: R-HSA-5693607;Reactome: R-HSA-5693616;Reactome: R-HSA-176187;Reactome: R-HSA-5685938;Reactome: R-HSA-69473;Reactome: R-HSA-6804756;Reactome: R-HSA-6783310	"Processing of DNA double-strand break ends";"Presynaptic phase of homologous DNA pairing and strand exchange";"Activation of ATR in response to replication stress";"HDR through Single Strand Annealing (SSA)";"G2/M DNA damage checkpoint";"Regulation of TP53 Activity through Phosphorylation";"Fanconi Anemia Pathway"
XP_046431962.1	1	Reactome: R-HSA-5683826	"Surfactant metabolism"
XP_046417054.1	2	Reactome: R-HSA-383280;Reactome: R-HSA-983231	"Nuclear Receptor transcription pathway";"Factors involved in megakaryocyte development and platelet production"
XP_046411248.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_046434101.1	2	Reactome: R-HSA-203927;Reactome: R-HSA-426486	"MicroRNA (miRNA) biogenesis";"Small interfering RNA (siRNA) biogenesis"
XP_046410047.1	5	MetaCyc: PWY-7863;KEGG: 00740+2.7.1.26;MetaCyc: PWY-6168;Reactome: R-HSA-196843;MetaCyc: PWY-5523	"Roseoflavin biosynthesis";"Riboflavin metabolism";"Flavin biosynthesis III (fungi)";"Vitamin B2 (riboflavin) metabolism";"5,6-dimethylbenzimidazole biosynthesis I (aerobic)"
XP_046409579.1	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
XP_046432999.1	2	Reactome: R-HSA-1799339;Reactome: R-HSA-381038	"SRP-dependent cotranslational protein targeting to membrane";"XBP1(S) activates chaperone genes"
XP_046425368.1	3	Reactome: R-HSA-9634638;Reactome: R-HSA-5663220;Reactome: R-HSA-525793	"Estrogen-dependent nuclear events downstream of ESR-membrane signaling";"RHO GTPases Activate Formins";"Myogenesis"
XP_046414740.1	2	KEGG: 00563+2.4.1.198;Reactome: R-HSA-162710	"Glycosylphosphatidylinositol (GPI)-anchor biosynthesis";"Synthesis of glycosylphosphatidylinositol (GPI)"
XP_046422070.1	2	Reactome: R-HSA-425393;Reactome: R-HSA-5223345	"Transport of inorganic cations/anions and amino acids/oligopeptides";"Miscellaneous transport and binding events"
XP_046433272.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046436310.1	4	MetaCyc: PWY-7494;MetaCyc: PWY-3722;KEGG: 00260+1.2.1.8+1.1.99.1;Reactome: R-HSA-6798163	"Choline degradation IV";"Glycine betaine biosynthesis II (Gram-positive bacteria)";"Glycine, serine and threonine metabolism";"Choline catabolism"
XP_046424481.1	6	MetaCyc: PWY-7782;MetaCyc: PWY-5884;MetaCyc: PWY-6733;Reactome: R-HSA-9640463;MetaCyc: PWY-7656;KEGG: 00073+1.2.1.84	"Plasmalogen biosynthesis";"Wax esters biosynthesis I";"Sporopollenin precursors biosynthesis";"Wax biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Cutin, suberine and wax biosynthesis"
XP_046427996.1	3	Reactome: R-HSA-416482;Reactome: R-HSA-194840;Reactome: R-HSA-193648	"G alpha (12/13) signalling events";"Rho GTPase cycle";"NRAGE signals death through JNK"
XP_046425910.1	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
XP_046415991.1	1	Reactome: R-HSA-70895	"Branched-chain amino acid catabolism"
XP_046435284.1	3	KEGG: 00730+3.1.3.2;MetaCyc: PWY-6348;KEGG: 00740+3.1.3.2	"Thiamine metabolism";"Phosphate acquisition";"Riboflavin metabolism"
XP_046434446.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046428843.1	1	Reactome: R-HSA-6799198	"Complex I biogenesis"
XP_046409734.1	5	Reactome: R-HSA-72165;Reactome: R-HSA-73856;Reactome: R-HSA-159236;Reactome: R-HSA-72187;Reactome: R-HSA-72163	"mRNA Splicing - Minor Pathway";"RNA Polymerase II Transcription Termination";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"mRNA 3'-end processing";"mRNA Splicing - Major Pathway"
XP_046412477.1	5	KEGG: 00564+2.7.7.41;MetaCyc: PWY-5667;MetaCyc: PWY-5981;MetaCyc: PWY-7817;KEGG: 04070+2.7.7.41	"Glycerophospholipid metabolism";"CDP-diacylglycerol biosynthesis I";"CDP-diacylglycerol biosynthesis III";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Phosphatidylinositol signaling system"
XP_046435904.1	2	Reactome: R-HSA-6807878;Reactome: R-HSA-445095	"COPI-mediated anterograde transport";"Interaction between L1 and Ankyrins"
XP_046424191.1	9	Reactome: R-HSA-167162;Reactome: R-HSA-167172;Reactome: R-HSA-75953;Reactome: R-HSA-76042;Reactome: R-HSA-167161;Reactome: R-HSA-6804756;Reactome: R-HSA-73779;Reactome: R-HSA-73776;Reactome: R-HSA-674695	"RNA Polymerase II HIV Promoter Escape";"Transcription of the HIV genome";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"HIV Transcription Initiation";"Regulation of TP53 Activity through Phosphorylation";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Pre-transcription Events"
XP_046428653.1	1	Reactome: R-HSA-525793	"Myogenesis"
XP_046435705.1	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
XP_046411465.1	2	KEGG: 00230+2.7.4.8;MetaCyc: PWY-7221	"Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis"
XP_046425272.1	26	Reactome: R-HSA-6811434;Reactome: R-HSA-9648025;Reactome: R-HSA-380320;Reactome: R-HSA-9609690;Reactome: R-HSA-2467813;Reactome: R-HSA-9619483;Reactome: R-HSA-1445148;Reactome: R-HSA-389960;Reactome: R-HSA-2500257;Reactome: R-HSA-983189;Reactome: R-HSA-5626467;Reactome: R-HSA-6807878;Reactome: R-HSA-5617833;Reactome: R-HSA-2132295;Reactome: R-HSA-8955332;Reactome: R-HSA-9609736;Reactome: R-HSA-8852276;Reactome: R-HSA-190840;Reactome: R-HSA-68877;Reactome: R-HSA-9646399;Reactome: R-HSA-190861;Reactome: R-HSA-6811436;Reactome: R-HSA-5663220;Reactome: R-HSA-389977;Reactome: R-HSA-437239;Reactome: R-HSA-3371497	"COPI-dependent Golgi-to-ER retrograde traffic";"EML4 and NUDC in mitotic spindle formation";"Recruitment of NuMA to mitotic centrosomes";"HCMV Early Events";"Separation of Sister Chromatids";"Activation of AMPK downstream of NMDARs";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Formation of tubulin folding intermediates by CCT/TriC";"Resolution of Sister Chromatid Cohesion";"Kinesins";"RHO GTPases activate IQGAPs";"COPI-mediated anterograde transport";"Cilium Assembly";"MHC class II antigen presentation";"Carboxyterminal post-translational modifications of tubulin";"Assembly and cell surface presentation of NMDA receptors";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Mitotic Prometaphase";"Aggrephagy";"Gap junction assembly";"COPI-independent Golgi-to-ER retrograde traffic";"RHO GTPases Activate Formins";"Post-chaperonin tubulin folding pathway";"Recycling pathway of L1";"HSP90 chaperone cycle for steroid hormone receptors (SHR)"
XP_046415439.1	1	Reactome: R-HSA-373080	"Class B/2 (Secretin family receptors)"
XP_046421642.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046419769.1	1	Reactome: R-HSA-390522	"Striated Muscle Contraction"
XP_046412110.1	17	Reactome: R-HSA-2173796;Reactome: R-HSA-69231;Reactome: R-HSA-1538133;Reactome: R-HSA-1912408;Reactome: R-HSA-111448;Reactome: R-HSA-2559585;Reactome: R-HSA-139915;Reactome: R-HSA-6804114;Reactome: R-HSA-1362300;Reactome: R-HSA-113501;Reactome: R-HSA-1362277;Reactome: R-HSA-69205;Reactome: R-HSA-69202;Reactome: R-HSA-2559580;Reactome: R-HSA-69656;Reactome: R-HSA-8953750;Reactome: R-HSA-9616222	"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"Cyclin D associated events in G1";"G0 and Early G1";"Pre-NOTCH Transcription and Translation";"Activation of NOXA and translocation to mitochondria";"Oncogene Induced Senescence";"Activation of PUMA and translocation to mitochondria";"TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest";"Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1";"Inhibition of replication initiation of damaged DNA by RB1/E2F1";"Transcription of E2F targets under negative control by DREAM complex";"G1/S-Specific Transcription";"Cyclin E associated events during G1/S transition";"Oxidative Stress Induced Senescence";"Cyclin A:Cdk2-associated events at S phase entry";"Transcriptional Regulation by E2F6";"Transcriptional regulation of granulopoiesis"
XP_046418842.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_046418793.1	2	Reactome: R-HSA-983168;Reactome: R-HSA-6798695	"Antigen processing: Ubiquitination & Proteasome degradation";"Neutrophil degranulation"
XP_046436723.1	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
XP_046430184.1	2	Reactome: R-HSA-8951671;Reactome: R-HSA-2032785	"RUNX3 regulates YAP1-mediated transcription";"YAP1- and WWTR1 (TAZ)-stimulated gene expression"
XP_046430511.1	7	Reactome: R-HSA-68877;Reactome: R-HSA-2467813;Reactome: R-HSA-9648025;Reactome: R-HSA-141444;Reactome: R-HSA-606279;Reactome: R-HSA-5663220;Reactome: R-HSA-2500257	"Mitotic Prometaphase";"Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Deposition of new CENPA-containing nucleosomes at the centromere";"RHO GTPases Activate Formins";"Resolution of Sister Chromatid Cohesion"
XP_046422861.1	1	Reactome: R-HSA-426048	"Arachidonate production from DAG"
XP_046433842.1	1	Reactome: R-HSA-1474228	"Degradation of the extracellular matrix"
XP_046416945.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046420594.1	2	Reactome: R-HSA-71403;Reactome: R-HSA-611105	"Citric acid cycle (TCA cycle)";"Respiratory electron transport"
XP_046422042.1	1	Reactome: R-HSA-5662702	"Melanin biosynthesis"
XP_046429939.1	3	Reactome: R-HSA-2022854;Reactome: R-HSA-5083627;Reactome: R-HSA-5173105	"Keratan sulfate biosynthesis";"Defective LARGE causes MDDGA6 and MDDGB6";"O-linked glycosylation"
XP_046412534.1	2	Reactome: R-HSA-5205685;Reactome: R-HSA-983231	"Pink/Parkin Mediated Mitophagy";"Factors involved in megakaryocyte development and platelet production"
XP_046436449.1	5	Reactome: R-HSA-2871796;KEGG: 04150+2.7.11.24;Reactome: R-HSA-450341;Reactome: R-HSA-450321;Reactome: R-HSA-2559580	"FCERI mediated MAPK activation";"mTOR signaling pathway";"Activation of the AP-1 family of transcription factors";"JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1";"Oxidative Stress Induced Senescence"
XP_046412504.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_046424736.1	5	MetaCyc: PWY-7279;MetaCyc: PWY-6692;MetaCyc: PWY-7082;KEGG: 00190+7.1.1.8;MetaCyc: PWY-3781	"Aerobic respiration II (cytochrome c) (yeast)";"Fe(II) oxidation";"Ammonia oxidation IV (autotrophic ammonia oxidizers)";"Oxidative phosphorylation";"Aerobic respiration I (cytochrome c)"
XP_046410555.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-3108214	"Protein ubiquitination";"SUMOylation of DNA damage response and repair proteins"
XP_046419383.1	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_046414169.1	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
XP_046430698.1	56	Reactome: R-HSA-349425;Reactome: R-HSA-5689880;Reactome: R-HSA-174084;Reactome: R-HSA-8951664;Reactome: R-HSA-4608870;Reactome: R-HSA-4641257;Reactome: R-HSA-75815;Reactome: R-HSA-202424;Reactome: R-HSA-1236978;Reactome: R-HSA-5610785;Reactome: R-HSA-180585;Reactome: R-HSA-5678895;Reactome: R-HSA-8939236;Reactome: R-HSA-5658442;Reactome: R-HSA-983168;Reactome: R-HSA-5607761;Reactome: R-HSA-174184;Reactome: R-HSA-8939902;Reactome: R-HSA-174154;Reactome: R-HSA-2467813;Reactome: R-HSA-8854050;Reactome: R-HSA-9020702;Reactome: R-HSA-5687128;Reactome: R-HSA-174113;Reactome: R-HSA-5607764;Reactome: R-HSA-187577;Reactome: R-HSA-180534;Reactome: R-HSA-5689603;Reactome: R-HSA-68827;Reactome: R-HSA-8852276;Reactome: R-HSA-5610783;Reactome: R-HSA-8948751;Reactome: R-HSA-1234176;Reactome: R-HSA-69481;Reactome: R-HSA-5632684;Reactome: R-HSA-211733;Reactome: R-HSA-4641258;Reactome: R-HSA-1236974;Reactome: R-HSA-450408;Reactome: R-HSA-5610780;Reactome: R-HSA-5668541;Reactome: R-HSA-350562;Reactome: R-HSA-9010553;Reactome: R-HSA-8941858;Reactome: R-HSA-5358346;Reactome: R-HSA-69601;Reactome: R-HSA-69017;Reactome: R-HSA-5362768;Reactome: R-HSA-9604323;Reactome: R-HSA-5676590;Reactome: R-HSA-174178;Reactome: R-HSA-2871837;Reactome: R-HSA-195253;Reactome: R-HSA-68949;Reactome: R-HSA-1169091;Reactome: R-HSA-382556	"Autodegradation of the E3 ubiquitin ligase COP1";"Ub-specific processing proteases";"Autodegradation of Cdh1 by Cdh1:APC/C";"Neddylation";"Asymmetric localization of PCP proteins";"Degradation of AXIN";"Ubiquitin-dependent degradation of Cyclin D";"Downstream TCR signaling";"Cross-presentation of soluble exogenous antigens (endosomes)";"GLI3 is processed to GLI3R by the proteasome";"Vif-mediated degradation of APOBEC3G";"Defective CFTR causes cystic fibrosis";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Regulation of RAS by GAPs";"Antigen processing: Ubiquitination & Proteasome degradation";"Dectin-1 mediated noncanonical NF-kB signaling";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Regulation of RUNX2 expression and activity";"APC/C:Cdc20 mediated degradation of Securin";"Separation of Sister Chromatids";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Interleukin-1 signaling";"MAPK6/MAPK4 signaling";"SCF-beta-TrCP mediated degradation of Emi1";"CLEC7A (Dectin-1) signaling";"SCF(Skp2)-mediated degradation of p27/p21";"Vpu mediated degradation of CD4";"UCH proteinases";"CDT1 association with the CDC6:ORC:origin complex";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Degradation of GLI2 by the proteasome";"Regulation of PTEN stability and activity";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"G2/M Checkpoints";"Hedgehog 'on' state";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Degradation of DVL";"ER-Phagosome pathway";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Degradation of GLI1 by the proteasome";"TNFR2 non-canonical NF-kB pathway";"Regulation of ornithine decarboxylase (ODC)";"Regulation of expression of SLITs and ROBOs";"Regulation of RUNX3 expression and activity";"Hedgehog ligand biogenesis";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"CDK-mediated phosphorylation and removal of Cdc6";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Negative regulation of NOTCH4 signaling";"NIK-->noncanonical NF-kB signaling";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"FCERI mediated NF-kB activation";"Degradation of beta-catenin by the destruction complex";"Orc1 removal from chromatin";"Activation of NF-kappaB in B cells";"ABC-family proteins mediated transport"
XP_046414188.1	1	Reactome: R-HSA-1660662	"Glycosphingolipid metabolism"
XP_046419909.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_046419638.1	1	Reactome: R-HSA-211897	"Cytochrome P450 - arranged by substrate type"
XP_046420031.1	19	Reactome: R-HSA-936837;Reactome: R-HSA-399719;Reactome: R-HSA-5578775;Reactome: R-HSA-9609736;Reactome: R-HSA-111932;Reactome: R-HSA-9022692;Reactome: R-HSA-438066;Reactome: R-HSA-9617324;Reactome: R-HSA-5576892;Reactome: R-HSA-877300;Reactome: R-HSA-6802955;Reactome: R-HSA-442982;Reactome: R-HSA-6802952;Reactome: R-HSA-9649948;Reactome: R-HSA-3371571;Reactome: R-HSA-5673001;Reactome: R-HSA-9620244;Reactome: R-HSA-5673000;Reactome: R-HSA-6802946	"Ion transport by P-type ATPases";"Trafficking of AMPA receptors";"Ion homeostasis";"Assembly and cell surface presentation of NMDA receptors";"CaMK IV-mediated phosphorylation of CREB";"Regulation of MECP2 expression and activity";"Unblocking of NMDA receptors, glutamate binding and activation";"Negative regulation of NMDA receptor-mediated neuronal transmission";"Phase 0 - rapid depolarisation";"Interferon gamma signaling";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"Ras activation upon Ca2+ influx through NMDA receptor";"Signaling by BRAF and RAF fusions";"Signaling downstream of RAS mutants";"HSF1-dependent transactivation";"RAF/MAP kinase cascade";"Long-term potentiation";"RAF activation";"Signaling by moderate kinase activity BRAF mutants"
XP_046421000.1	1	Reactome: R-HSA-432047	"Passive transport by Aquaporins"
XP_046409820.1	2	KEGG: 00670+2.1.2.10;KEGG: 00260+2.1.2.10	"One carbon pool by folate";"Glycine, serine and threonine metabolism"
XP_046421613.1	3	KEGG: 04070+2.7.4.24+2.7.4.21;Reactome: R-HSA-1855167;MetaCyc: PWY-6369	"Phosphatidylinositol signaling system";"Synthesis of pyrophosphates in the cytosol";"Inositol diphosphates biosynthesis"
XP_046431875.1	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
XP_046420059.1	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
XP_046418320.1	8	MetaCyc: PWY-5740;MetaCyc: PWY-5738;KEGG: 00051+4.2.1.47;MetaCyc: PWY-5739;KEGG: 00520+4.2.1.47;MetaCyc: PWY-7573;Reactome: R-HSA-6787639;MetaCyc: PWY-66	"GDP-L-colitose biosynthesis";"GDP-6-deoxy-D-talose biosynthesis";"Fructose and mannose metabolism";"GDP-D-perosamine biosynthesis";"Amino sugar and nucleotide sugar metabolism";"GDP-mycosamine biosynthesis";"GDP-fucose biosynthesis";"GDP-L-fucose biosynthesis I (from GDP-D-mannose)"
XP_046426565.1	1	Reactome: R-HSA-5693571	"Nonhomologous End-Joining (NHEJ)"
XP_046409644.1	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
XP_046428766.1	13	Reactome: R-HSA-156902;Reactome: R-HSA-975956;Reactome: R-HSA-72764;Reactome: R-HSA-975957;Reactome: R-HSA-6791226;Reactome: R-HSA-72706;Reactome: R-HSA-2408557;Reactome: R-HSA-1799339;Reactome: R-HSA-72689;Reactome: R-HSA-9633012;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-192823	"Peptide chain elongation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Selenocysteine synthesis";"SRP-dependent cotranslational protein targeting to membrane";"Formation of a pool of free 40S subunits";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Viral mRNA Translation"
XP_046425391.1	2	Reactome: R-HSA-917729;Reactome: R-HSA-162588	"Endosomal Sorting Complex Required For Transport (ESCRT)";"Budding and maturation of HIV virion"
XP_046417195.1	32	Reactome: R-HSA-167242;Reactome: R-HSA-674695;Reactome: R-HSA-6796648;Reactome: R-HSA-77075;Reactome: R-HSA-167200;Reactome: R-HSA-167290;Reactome: R-HSA-6803529;Reactome: R-HSA-167152;Reactome: R-HSA-167172;Reactome: R-HSA-73779;Reactome: R-HSA-167160;Reactome: R-HSA-75953;Reactome: R-HSA-72165;Reactome: R-HSA-167246;Reactome: R-HSA-167238;Reactome: R-HSA-73776;Reactome: R-HSA-72086;Reactome: R-HSA-168325;Reactome: R-HSA-9018519;Reactome: R-HSA-8851708;Reactome: R-HSA-167161;Reactome: R-HSA-76042;Reactome: R-HSA-72203;Reactome: R-HSA-75955;Reactome: R-HSA-112382;Reactome: R-HSA-167243;Reactome: R-HSA-72163;Reactome: R-HSA-167158;Reactome: R-HSA-167287;Reactome: R-HSA-167162;Reactome: R-HSA-6807505;Reactome: R-HSA-113418	"Abortive elongation of HIV-1 transcript in the absence of Tat";"RNA Polymerase II Pre-transcription Events";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Pol II CTD phosphorylation and interaction with CE";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"Pausing and recovery of HIV elongation";"FGFR2 alternative splicing";"Formation of HIV elongation complex in the absence of HIV Tat";"Transcription of the HIV genome";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"RNA Polymerase II Transcription Initiation";"mRNA Splicing - Minor Pathway";"Tat-mediated elongation of the HIV-1 transcript";"Pausing and recovery of Tat-mediated HIV elongation";"RNA Polymerase II Promoter Escape";"mRNA Capping";"Viral Messenger RNA Synthesis";"Estrogen-dependent gene expression";"Signaling by FGFR2 IIIa TM";"HIV Transcription Initiation";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Processing of Capped Intron-Containing Pre-mRNA";"RNA Polymerase II Transcription Elongation";"Formation of RNA Pol II elongation complex";"Tat-mediated HIV elongation arrest and recovery";"mRNA Splicing - Major Pathway";"Formation of the HIV-1 Early Elongation Complex";"HIV elongation arrest and recovery";"RNA Polymerase II HIV Promoter Escape";"RNA polymerase II transcribes snRNA genes";"Formation of the Early Elongation Complex"
XP_046433694.1	14	Reactome: R-HSA-167152;Reactome: R-HSA-167290;Reactome: R-HSA-6796648;Reactome: R-HSA-167200;Reactome: R-HSA-167287;Reactome: R-HSA-167242;Reactome: R-HSA-167158;Reactome: R-HSA-674695;Reactome: R-HSA-167243;Reactome: R-HSA-167238;Reactome: R-HSA-112382;Reactome: R-HSA-113418;Reactome: R-HSA-75955;Reactome: R-HSA-167246	"Formation of HIV elongation complex in the absence of HIV Tat";"Pausing and recovery of HIV elongation";"TP53 Regulates Transcription of DNA Repair Genes";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"HIV elongation arrest and recovery";"Abortive elongation of HIV-1 transcript in the absence of Tat";"Formation of the HIV-1 Early Elongation Complex";"RNA Polymerase II Pre-transcription Events";"Tat-mediated HIV elongation arrest and recovery";"Pausing and recovery of Tat-mediated HIV elongation";"Formation of RNA Pol II elongation complex";"Formation of the Early Elongation Complex";"RNA Polymerase II Transcription Elongation";"Tat-mediated elongation of the HIV-1 transcript"
XP_046420237.1	7	MetaCyc: PWY-7039;KEGG: 00564+3.1.4.4;MetaCyc: PWY-3561;Reactome: R-HSA-1483148;Reactome: R-HSA-2029485;KEGG: 00565+3.1.4.4;Reactome: R-HSA-1483166	"Phosphatidate metabolism, as a signaling molecule";"Glycerophospholipid metabolism";"Choline biosynthesis III";"Synthesis of PG";"Role of phospholipids in phagocytosis";"Ether lipid metabolism";"Synthesis of PA"
XP_046417037.1	5	Reactome: R-HSA-111447;Reactome: R-HSA-5628897;Reactome: R-HSA-75035;Reactome: R-HSA-1445148;Reactome: R-HSA-5625740	"Activation of BAD and translocation to mitochondria";"TP53 Regulates Metabolic Genes";"Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"RHO GTPases activate PKNs"
XP_046433564.1	3	MetaCyc: PWY-7511;Reactome: R-HSA-983168;Reactome: R-HSA-1358803	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation";"Downregulation of ERBB2:ERBB3 signaling"
XP_046426014.1	20	MetaCyc: PWY-5136;Reactome: R-HSA-9033241;KEGG: 00410+1.3.3.6;MetaCyc: PWY-6837;KEGG: 00640+1.3.3.6;KEGG: 00592+1.3.3.6;MetaCyc: PWY-735;MetaCyc: PWY-7338;KEGG: 00071+1.3.3.6;MetaCyc: PWY-6920;MetaCyc: PWY-7291;MetaCyc: PWY-7858;MetaCyc: PWY-7337;MetaCyc: PWY-7574;MetaCyc: PWY-7340;MetaCyc: PWY-7288;MetaCyc: PWY-7726;MetaCyc: PWY-7606;MetaCyc: PWY-7007;MetaCyc: PWY-7854	"Fatty acid beta-oxidation II (plant peroxisome)";"Peroxisomal protein import";"beta-Alanine metabolism";"Fatty acid beta-oxidation V (unsaturated, odd number, di-isomerase-dependent)";"Propanoate metabolism";"alpha-Linolenic acid metabolism";"Jasmonic acid biosynthesis";"10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast)";"Fatty acid degradation";"6-gingerol analog biosynthesis (engineered)";"Oleate beta-oxidation (isomerase-dependent, yeast)";"(5Z)-dodecenoate biosynthesis II";"10-cis-heptadecenoyl-CoA degradation (yeast)";"Propanoyl-coa degradation II";"9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast)";"Fatty acid beta-oxidation VII (yeast peroxisome)";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Methyl ketone biosynthesis (engineered)";"Crotonyl-coa/ethylmalonyl-coa/hydroxybutyryl-coa cycle (engineered)"
XP_046428652.1	1	Reactome: R-HSA-525793	"Myogenesis"
XP_046426176.1	2	Reactome: R-HSA-389661;Reactome: R-HSA-9033241	"Glyoxylate metabolism and glycine degradation";"Peroxisomal protein import"
XP_046426289.1	2	Reactome: R-HSA-73980;Reactome: R-HSA-749476	"RNA Polymerase III Transcription Termination";"RNA Polymerase III Abortive And Retractive Initiation"
XP_046421517.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046423885.1	16	Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-9633012;Reactome: R-HSA-72706;Reactome: R-HSA-2408557;Reactome: R-HSA-6791226;Reactome: R-HSA-975956;Reactome: R-HSA-72702;Reactome: R-HSA-192823;Reactome: R-HSA-72689;Reactome: R-HSA-1799339;Reactome: R-HSA-72695;Reactome: R-HSA-975957;Reactome: R-HSA-72649;Reactome: R-HSA-72764;Reactome: R-HSA-156902	"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Selenocysteine synthesis";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Ribosomal scanning and start codon recognition";"Viral mRNA Translation";"Formation of a pool of free 40S subunits";"SRP-dependent cotranslational protein targeting to membrane";"Formation of the ternary complex, and subsequently, the 43S complex";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Translation initiation complex formation";"Eukaryotic Translation Termination";"Peptide chain elongation"
XP_046436443.1	5	KEGG: 04150+2.7.11.24;Reactome: R-HSA-2871796;Reactome: R-HSA-450321;Reactome: R-HSA-450341;Reactome: R-HSA-2559580	"mTOR signaling pathway";"FCERI mediated MAPK activation";"JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1";"Activation of the AP-1 family of transcription factors";"Oxidative Stress Induced Senescence"
XP_046420246.1	15	Reactome: R-HSA-196299;Reactome: R-HSA-5358749;Reactome: R-HSA-5689896;Reactome: R-HSA-5467337;Reactome: R-HSA-5467348;Reactome: R-HSA-5358751;Reactome: R-HSA-5467333;Reactome: R-HSA-195253;Reactome: R-HSA-5358752;Reactome: R-HSA-3769402;Reactome: R-HSA-111465;Reactome: R-HSA-5358747;Reactome: R-HSA-4641262;Reactome: R-HSA-5339716;Reactome: R-HSA-5467340	"Beta-catenin phosphorylation cascade";"S37 mutants of beta-catenin aren't phosphorylated";"Ovarian tumor domain proteases";"APC truncation mutants have impaired AXIN binding";"Truncations of AMER1 destabilize the destruction complex";"S45 mutants of beta-catenin aren't phosphorylated";"APC truncation mutants are not K63 polyubiquitinated";"Degradation of beta-catenin by the destruction complex";"T41 mutants of beta-catenin aren't phosphorylated";"Deactivation of the beta-catenin transactivating complex";"Apoptotic cleavage of cellular proteins";"S33 mutants of beta-catenin aren't phosphorylated";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"Misspliced GSK3beta mutants stabilize beta-catenin";"AXIN missense mutants destabilize the destruction complex"
XP_046421248.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046420234.1	10	Reactome: R-HSA-8936459;Reactome: R-HSA-9022702;Reactome: R-HSA-9615017;Reactome: R-HSA-400206;Reactome: R-HSA-427413;Reactome: R-HSA-983231;Reactome: R-HSA-9022699;Reactome: R-HSA-3899300;Reactome: R-HSA-9022538;Reactome: R-HSA-9022692	"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"MECP2 regulates transcription of neuronal ligands";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"Regulation of lipid metabolism by PPARalpha";"NoRC negatively regulates rRNA expression";"Factors involved in megakaryocyte development and platelet production";"MECP2 regulates neuronal receptors and channels";"SUMOylation of transcription cofactors";"Loss of MECP2 binding ability to 5mC-DNA";"Regulation of MECP2 expression and activity"
XP_046414177.1	1	Reactome: R-HSA-5658442	"Regulation of RAS by GAPs"
XP_046427982.1	14	Reactome: R-HSA-4086398;Reactome: R-HSA-8986944;Reactome: R-HSA-8943723;Reactome: R-HSA-1912408;Reactome: R-HSA-8948700;Reactome: R-HSA-5628897;Reactome: R-HSA-426486;Reactome: R-HSA-8934593;Reactome: R-HSA-9018519;Reactome: R-HSA-426496;Reactome: R-HSA-9029569;Reactome: R-HSA-203927;Reactome: R-HSA-9022692;Reactome: R-HSA-5687128	"Ca2+ pathway";"Transcriptional Regulation by MECP2";"Regulation of PTEN mRNA translation";"Pre-NOTCH Transcription and Translation";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"TP53 Regulates Metabolic Genes";"Small interfering RNA (siRNA) biogenesis";"Regulation of RUNX1 Expression and Activity";"Estrogen-dependent gene expression";"Post-transcriptional silencing by small RNAs";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"MicroRNA (miRNA) biogenesis";"Regulation of MECP2 expression and activity";"MAPK6/MAPK4 signaling"
XP_046426287.1	2	Reactome: R-HSA-73980;Reactome: R-HSA-749476	"RNA Polymerase III Transcription Termination";"RNA Polymerase III Abortive And Retractive Initiation"
XP_046421483.1	8	Reactome: R-HSA-6798695;Reactome: R-HSA-166208;Reactome: R-HSA-1632852;Reactome: R-HSA-165159;Reactome: R-HSA-380972;Reactome: R-HSA-8943724;Reactome: R-HSA-9639288;Reactome: R-HSA-5628897	"Neutrophil degranulation";"mTORC1-mediated signalling";"Macroautophagy";"mTOR signalling";"Energy dependent regulation of mTOR by LKB1-AMPK";"Regulation of PTEN gene transcription";"Amino acids regulate mTORC1";"TP53 Regulates Metabolic Genes"
XP_046416840.1	1	Reactome: R-HSA-373080	"Class B/2 (Secretin family receptors)"
XP_046419619.1	5	Reactome: R-HSA-499943;MetaCyc: PWY-7176;MetaCyc: PWY-7185;KEGG: 00240+6.3.4.2;MetaCyc: PWY-7177	"Interconversion of nucleotide di- and triphosphates";"UTP and CTP de novo biosynthesis";"UTP and CTP dephosphorylation I";"Pyrimidine metabolism";"UTP and CTP dephosphorylation II"
XP_046430164.1	12	MetaCyc: PWY-5870;MetaCyc: PWY-5856;KEGG: 00130+2.5.1.39;MetaCyc: PWY-6708;MetaCyc: PWY-5857;MetaCyc: PWY-5855;Reactome: R-HSA-2142789;MetaCyc: PWY-5873;MetaCyc: PWY-5871;MetaCyc: PWY-6978;Reactome: R-HSA-1268020;MetaCyc: PWY-5872	"Ubiquinol-8 biosynthesis (eukaryotic)";"Ubiquinol-9 biosynthesis (prokaryotic)";"Ubiquinone and other terpenoid-quinone biosynthesis";"Ubiquinol-8 biosynthesis (prokaryotic)";"Ubiquinol-10 biosynthesis (prokaryotic)";"Ubiquinol-7 biosynthesis (prokaryotic)";"Ubiquinol biosynthesis";"Ubiquinol-7 biosynthesis (eukaryotic)";"Ubiquinol-9 biosynthesis (eukaryotic)";"Plastoquinol-9 biosynthesis II";"Mitochondrial protein import";"Ubiquinol-10 biosynthesis (eukaryotic)"
XP_046423931.1	6	Reactome: R-HSA-9640463;MetaCyc: PWY-6733;KEGG: 00073+1.2.1.84;MetaCyc: PWY-7656;MetaCyc: PWY-5884;MetaCyc: PWY-7782	"Wax biosynthesis";"Sporopollenin precursors biosynthesis";"Cutin, suberine and wax biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Wax esters biosynthesis I";"Plasmalogen biosynthesis"
XP_046431780.1	16	Reactome: R-HSA-179409;Reactome: R-HSA-176412;Reactome: R-HSA-174048;Reactome: R-HSA-8853884;Reactome: R-HSA-176409;Reactome: R-HSA-174084;Reactome: R-HSA-2467813;Reactome: R-HSA-174178;Reactome: R-HSA-2559582;Reactome: R-HSA-176407;Reactome: R-HSA-176408;Reactome: R-HSA-174184;Reactome: R-HSA-174154;Reactome: R-HSA-69017;Reactome: R-HSA-983168;Reactome: R-HSA-141430	"APC-Cdc20 mediated degradation of Nek2A";"Phosphorylation of the APC/C";"APC/C:Cdc20 mediated degradation of Cyclin B";"Transcriptional Regulation by VENTX";"APC/C:Cdc20 mediated degradation of mitotic proteins";"Autodegradation of Cdh1 by Cdh1:APC/C";"Separation of Sister Chromatids";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Senescence-Associated Secretory Phenotype (SASP)";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"Regulation of APC/C activators between G1/S and early anaphase";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"APC/C:Cdc20 mediated degradation of Securin";"CDK-mediated phosphorylation and removal of Cdc6";"Antigen processing: Ubiquitination & Proteasome degradation";"Inactivation of APC/C via direct inhibition of the APC/C complex"
XP_046427494.1	2	Reactome: R-HSA-5576892;Reactome: R-HSA-5576893	"Phase 0 - rapid depolarisation";"Phase 2 - plateau phase"
XP_046422956.1	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
XP_046432089.1	7	KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1	"Human cytomegalovirus infection";"Thermogenesis";"Relaxin signaling pathway";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"mTOR signaling pathway"
XP_046410551.1	6	Reactome: R-HSA-6791226;Reactome: R-HSA-450385;Reactome: R-HSA-380994;Reactome: R-HSA-429958;Reactome: R-HSA-450604;Reactome: R-HSA-450513	"Major pathway of rRNA processing in the nucleolus and cytosol";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"ATF4 activates genes in response to endoplasmic reticulum stress";"mRNA decay by 3' to 5' exoribonuclease";"KSRP (KHSRP) binds and destabilizes mRNA";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA"
XP_046430420.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046415041.1	14	Reactome: R-HSA-167158;Reactome: R-HSA-167242;Reactome: R-HSA-674695;Reactome: R-HSA-6796648;Reactome: R-HSA-167200;Reactome: R-HSA-167287;Reactome: R-HSA-167290;Reactome: R-HSA-167152;Reactome: R-HSA-75955;Reactome: R-HSA-167246;Reactome: R-HSA-112382;Reactome: R-HSA-113418;Reactome: R-HSA-167243;Reactome: R-HSA-167238	"Formation of the HIV-1 Early Elongation Complex";"Abortive elongation of HIV-1 transcript in the absence of Tat";"RNA Polymerase II Pre-transcription Events";"TP53 Regulates Transcription of DNA Repair Genes";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"HIV elongation arrest and recovery";"Pausing and recovery of HIV elongation";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Polymerase II Transcription Elongation";"Tat-mediated elongation of the HIV-1 transcript";"Formation of RNA Pol II elongation complex";"Formation of the Early Elongation Complex";"Tat-mediated HIV elongation arrest and recovery";"Pausing and recovery of Tat-mediated HIV elongation"
XP_046415818.1	6	MetaCyc: PWY-5884;MetaCyc: PWY-7782;KEGG: 00073+1.2.1.84;MetaCyc: PWY-7656;Reactome: R-HSA-9640463;MetaCyc: PWY-6733	"Wax esters biosynthesis I";"Plasmalogen biosynthesis";"Cutin, suberine and wax biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Wax biosynthesis";"Sporopollenin precursors biosynthesis"
XP_046417596.1	6	Reactome: R-HSA-8863795;MetaCyc: PWY-7511;Reactome: R-HSA-8939902;Reactome: R-HSA-983168;Reactome: R-HSA-8948751;Reactome: R-HSA-2173788	"Downregulation of ERBB2 signaling";"Protein ubiquitination";"Regulation of RUNX2 expression and activity";"Antigen processing: Ubiquitination & Proteasome degradation";"Regulation of PTEN stability and activity";"Downregulation of TGF-beta receptor signaling"
XP_046409485.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046426330.1	2	MetaCyc: PWY-4261;KEGG: 00561+2.7.1.30	"Glycerol degradation I";"Glycerolipid metabolism"
XP_046433941.1	5	Reactome: R-HSA-6782210;Reactome: R-HSA-72163;Reactome: R-HSA-6781827;Reactome: R-HSA-6782135;Reactome: R-HSA-6781823	"Gap-filling DNA repair synthesis and ligation in TC-NER";"mRNA Splicing - Major Pathway";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Dual incision in TC-NER";"Formation of TC-NER Pre-Incision Complex"
XP_046428672.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046420955.1	3	KEGG: 00051+1.1.1.271;Reactome: R-HSA-6787639;KEGG: 00520+1.1.1.271	"Fructose and mannose metabolism";"GDP-fucose biosynthesis";"Amino sugar and nucleotide sugar metabolism"
XP_046418947.1	14	MetaCyc: PWY-7411;Reactome: R-HSA-1483166;MetaCyc: PWY-7587;KEGG: 00561+2.3.1.51;MetaCyc: PWY-8055;MetaCyc: PWY-6453;KEGG: 00564+2.3.1.51;MetaCyc: PWY-8051;MetaCyc: PWY-5667;MetaCyc: PWY-7417;MetaCyc: PWY-7589;MetaCyc: PWY-7782;MetaCyc: PWY-5981;MetaCyc: PWY-8053	"Phosphatidate biosynthesis (yeast)";"Synthesis of PA";"Oleate biosynthesis III (cyanobacteria)";"Glycerolipid metabolism";"Palmitoyl ethanolamide biosynthesis";"Stigma estolide biosynthesis";"Glycerophospholipid metabolism";"Anandamide biosynthesis I";"CDP-diacylglycerol biosynthesis I";"Phospholipid remodeling (phosphatidate, yeast)";"Palmitoleate biosynthesis III (cyanobacteria)";"Plasmalogen biosynthesis";"CDP-diacylglycerol biosynthesis III";"Anandamide biosynthesis II"
XP_046417538.1	2	Reactome: R-HSA-936837;Reactome: R-HSA-6798695	"Ion transport by P-type ATPases";"Neutrophil degranulation"
XP_046416157.1	6	Reactome: R-HSA-380994;Reactome: R-HSA-429958;Reactome: R-HSA-450604;Reactome: R-HSA-450513;Reactome: R-HSA-6791226;Reactome: R-HSA-450385	"ATF4 activates genes in response to endoplasmic reticulum stress";"mRNA decay by 3' to 5' exoribonuclease";"KSRP (KHSRP) binds and destabilizes mRNA";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"Major pathway of rRNA processing in the nucleolus and cytosol";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA"
XP_046412058.1	3	Reactome: R-HSA-390471;Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"Association of TriC/CCT with target proteins during biosynthesis";"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
XP_046421766.1	1	Reactome: R-HSA-5624958	"ARL13B-mediated ciliary trafficking of INPP5E"
XP_046423231.1	13	KEGG: 00720+6.2.1.5;MetaCyc: PWY-5537;MetaCyc: PWY-5392;KEGG: 00660+6.2.1.5;KEGG: 00640+6.2.1.5;MetaCyc: PWY-5913;MetaCyc: PWY-6728;MetaCyc: PWY-5538;MetaCyc: PWY-6969;MetaCyc: PWY-5690;Reactome: R-HSA-71403;MetaCyc: PWY-7384;KEGG: 00020+6.2.1.5	"Carbon fixation pathways in prokaryotes";"Pyruvate fermentation to acetate V";"Reductive TCA cycle II";"C5-Branched dibasic acid metabolism";"Propanoate metabolism";"Partial TCA cycle (obligate autotrophs)";"Methylaspartate cycle";"Pyruvate fermentation to acetate VI";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"TCA cycle II (plants and fungi)";"Citric acid cycle (TCA cycle)";"Anaerobic energy metabolism (invertebrates, mitochondrial)";"Citrate cycle (TCA cycle)"
XP_046436734.1	3	Reactome: R-HSA-3232118;Reactome: R-HSA-3899300;Reactome: R-HSA-4090294	"SUMOylation of transcription factors";"SUMOylation of transcription cofactors";"SUMOylation of intracellular receptors"
XP_046435445.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046427914.1	6	KEGG: 04070+2.7.1.107;KEGG: 00564+2.7.1.107;Reactome: R-HSA-114508;MetaCyc: PWY-7817;MetaCyc: PWY-7039;KEGG: 00561+2.7.1.107	"Phosphatidylinositol signaling system";"Glycerophospholipid metabolism";"Effects of PIP2 hydrolysis";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Phosphatidate metabolism, as a signaling molecule";"Glycerolipid metabolism"
XP_046417142.1	2	Reactome: R-HSA-168928;Reactome: R-HSA-70350	"DDX58/IFIH1-mediated induction of interferon-alpha/beta";"Fructose catabolism"
XP_046427731.1	1	Reactome: R-HSA-1660661	"Sphingolipid de novo biosynthesis"
XP_046416743.1	2	Reactome: R-HSA-8936459;Reactome: R-HSA-3214841	"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"PKMTs methylate histone lysines"
XP_046434812.1	1	Reactome: R-HSA-3214815	"HDACs deacetylate histones"
XP_046421994.1	2	Reactome: R-HSA-418457;Reactome: R-HSA-1296052	"cGMP effects";"Ca2+ activated K+ channels"
XP_046429438.1	1	Reactome: R-HSA-1632852	"Macroautophagy"
XP_046410244.1	1	Reactome: R-HSA-975957	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
XP_046422854.1	1	Reactome: R-HSA-426048	"Arachidonate production from DAG"
XP_046416327.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_046418785.1	2	Reactome: R-HSA-6798695;Reactome: R-HSA-983168	"Neutrophil degranulation";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046428139.1	2	Reactome: R-HSA-5682910;Reactome: R-HSA-5250971	"LGI-ADAM interactions";"Toxicity of botulinum toxin type C (BoNT/C)"
XP_046429693.1	1	Reactome: R-HSA-388844	"Receptor-type tyrosine-protein phosphatases"
XP_046415015.1	7	MetaCyc: PWY-5921;KEGG: 00250+3.5.1.2;Reactome: R-HSA-210500;Reactome: R-HSA-5628897;Reactome: R-HSA-8964539;KEGG: 00471+3.5.1.2;KEGG: 00220+3.5.1.2	"Glutaminyl-trnagln biosynthesis via transamidation";"Alanine, aspartate and glutamate metabolism";"Glutamate Neurotransmitter Release Cycle";"TP53 Regulates Metabolic Genes";"Glutamate and glutamine metabolism";"D-Glutamine and D-glutamate metabolism";"Arginine biosynthesis"
XP_046427578.1	1	Reactome: R-HSA-5620922	"BBSome-mediated cargo-targeting to cilium"
XP_046424966.1	1	MetaCyc: PWY-7942	"5-oxo-L-proline metabolism"
XP_046424177.1	6	Reactome: R-HSA-2500257;Reactome: R-HSA-5663220;Reactome: R-HSA-2467813;Reactome: R-HSA-68877;Reactome: R-HSA-141444;Reactome: R-HSA-9648025	"Resolution of Sister Chromatid Cohesion";"RHO GTPases Activate Formins";"Separation of Sister Chromatids";"Mitotic Prometaphase";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"EML4 and NUDC in mitotic spindle formation"
XP_046420373.1	3	Reactome: R-HSA-4420097;Reactome: R-HSA-2029482;Reactome: R-HSA-5663213	"VEGFA-VEGFR2 Pathway";"Regulation of actin dynamics for phagocytic cup formation";"RHO GTPases Activate WASPs and WAVEs"
XP_046415379.1	1	Reactome: R-HSA-111957	"Cam-PDE 1 activation"
XP_046424500.1	9	MetaCyc: PWY-7115;MetaCyc: PWY-5743;MetaCyc: PWY-7117;MetaCyc: PWY-5744;MetaCyc: PWY-5789;MetaCyc: PWY-6142;MetaCyc: PWY-241;KEGG: 00910+4.2.1.1;Reactome: R-HSA-1475029	"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"3-hydroxypropanoate cycle";"C4 photosynthetic carbon assimilation cycle, PEPCK type";"Glyoxylate assimilation";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"C4 photosynthetic carbon assimilation cycle, NADP-ME type";"Nitrogen metabolism";"Reversible hydration of carbon dioxide"
XP_046430076.1	1	Reactome: R-HSA-70171	"Glycolysis"
XP_046426942.1	3	KEGG: 00740+3.1.3.2;MetaCyc: PWY-6348;KEGG: 00730+3.1.3.2	"Riboflavin metabolism";"Phosphate acquisition";"Thiamine metabolism"
XP_046419063.1	1	Reactome: R-HSA-5658442	"Regulation of RAS by GAPs"
XP_046428838.1	5	Reactome: R-HSA-5579026;Reactome: R-HSA-1362409;Reactome: R-HSA-2395516;Reactome: R-HSA-211976;Reactome: R-HSA-196108	"Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR)";"Mitochondrial iron-sulfur cluster biogenesis";"Electron transport from NADPH to Ferredoxin";"Endogenous sterols";"Pregnenolone biosynthesis"
XP_046433349.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046409383.1	1	Reactome: R-HSA-5620912	"Anchoring of the basal body to the plasma membrane"
XP_046427287.1	1	Reactome: R-HSA-5656169	"Termination of translesion DNA synthesis"
XP_046414121.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_046434543.1	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840	"Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation"
XP_046409622.1	5	MetaCyc: PWY-7817;MetaCyc: PWY-5667;MetaCyc: PWY-5981;KEGG: 00564+2.7.7.41;KEGG: 04070+2.7.7.41	"Type I lipoteichoic acid biosynthesis (S. aureus)";"CDP-diacylglycerol biosynthesis I";"CDP-diacylglycerol biosynthesis III";"Glycerophospholipid metabolism";"Phosphatidylinositol signaling system"
XP_046414590.1	3	Reactome: R-HSA-9609736;Reactome: R-HSA-6794361;Reactome: R-HSA-212676	"Assembly and cell surface presentation of NMDA receptors";"Neurexins and neuroligins";"Dopamine Neurotransmitter Release Cycle"
XP_046434117.1	4	MetaCyc: PWY-5189;KEGG: 00860+2.5.1.61;Reactome: R-HSA-189451;MetaCyc: PWY-5188	"Tetrapyrrole biosynthesis II (from glycine)";"Porphyrin and chlorophyll metabolism";"Heme biosynthesis";"Tetrapyrrole biosynthesis I (from glutamate)"
XP_046414789.1	16	Reactome: R-HSA-8866427;Reactome: R-HSA-182218;Reactome: R-HSA-167590;Reactome: R-HSA-416993;Reactome: R-HSA-3928665;Reactome: R-HSA-196025;Reactome: R-HSA-164939;Reactome: R-HSA-190873;Reactome: R-HSA-5099900;Reactome: R-HSA-5140745;Reactome: R-HSA-8856828;Reactome: R-HSA-2132295;Reactome: R-HSA-177504;Reactome: R-HSA-8964038;Reactome: R-HSA-437239;Reactome: R-HSA-8856825	"VLDLR internalisation and degradation";"Nef Mediated CD8 Down-regulation";"Nef Mediated CD4 Down-regulation";"Trafficking of GluR2-containing AMPA receptors";"EPH-ephrin mediated repulsion of cells";"Formation of annular gap junctions";"Nef mediated downregulation of CD28 cell surface expression";"Gap junction degradation";"WNT5A-dependent internalization of FZD4";"WNT5A-dependent internalization of FZD2, FZD5 and ROR2";"Clathrin-mediated endocytosis";"MHC class II antigen presentation";"Retrograde neurotrophin signalling";"LDL clearance";"Recycling pathway of L1";"Cargo recognition for clathrin-mediated endocytosis"
XP_046414339.1	2	Reactome: R-HSA-418594;Reactome: R-HSA-6814122	"G alpha (i) signalling events";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"
XP_046415004.1	4	Reactome: R-HSA-2500257;Reactome: R-HSA-2470946;Reactome: R-HSA-2468052;Reactome: R-HSA-2467813	"Resolution of Sister Chromatid Cohesion";"Cohesin Loading onto Chromatin";"Establishment of Sister Chromatid Cohesion";"Separation of Sister Chromatids"
XP_046435999.1	10	KEGG: 00460+2.3.2.2;MetaCyc: PWY-8001;MetaCyc: PWY-4041;MetaCyc: PWY-4061;MetaCyc: PWY-7112;KEGG: 00430+2.3.2.2;KEGG: 00480+2.3.2.2+3.4.19.13;MetaCyc: PWY-7559;MetaCyc: PWY-6842;MetaCyc: PWY-5826	"Cyanoamino acid metabolism";"Felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis";"Gamma-glutamyl cycle";"Glutathione-mediated detoxification I";"4-hydroxy-2-nonenal detoxification";"Taurine and hypotaurine metabolism";"Glutathione metabolism";"Glutathione degradation (DUG pathway";"Glutathione-mediated detoxification II";"Hypoglycin biosynthesis"
XP_046435945.1	2	Reactome: R-HSA-917729;Reactome: R-HSA-9610379	"Endosomal Sorting Complex Required For Transport (ESCRT)";"HCMV Late Events"
XP_046414255.1	1	Reactome: R-HSA-203927	"MicroRNA (miRNA) biogenesis"
XP_046418009.1	1	Reactome: R-HSA-389977	"Post-chaperonin tubulin folding pathway"
XP_046413864.1	2	Reactome: R-HSA-5625740;KEGG: 04070+2.7.11.13	"RHO GTPases activate PKNs";"Phosphatidylinositol signaling system"
XP_046419728.1	1	Reactome: R-HSA-203641	"NOSTRIN mediated eNOS trafficking"
XP_046411687.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_046430243.1	5	KEGG: 00720+4.2.1.3;Reactome: R-HSA-917937;KEGG: 00630+4.2.1.3;KEGG: 00020+4.2.1.3;KEGG: 00290+4.2.1.33	"Carbon fixation pathways in prokaryotes";"Iron uptake and transport";"Glyoxylate and dicarboxylate metabolism";"Citrate cycle (TCA cycle)";"Valine, leucine and isoleucine biosynthesis"
XP_046412696.1	4	Reactome: R-HSA-73817;KEGG: 00230+6.3.5.2;MetaCyc: PWY-7221;KEGG: 00983+6.3.5.2	"Purine ribonucleoside monophosphate biosynthesis";"Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis";"Drug metabolism - other enzymes"
XP_046413815.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046413661.1	1	Reactome: R-HSA-9609523	"Insertion of tail-anchored proteins into the endoplasmic reticulum membrane"
XP_046432419.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_046429517.1	1	Reactome: R-HSA-419771	"Opsins"
XP_046431333.1	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
XP_046436446.1	5	Reactome: R-HSA-2871796;KEGG: 04150+2.7.11.24;Reactome: R-HSA-450321;Reactome: R-HSA-450341;Reactome: R-HSA-2559580	"FCERI mediated MAPK activation";"mTOR signaling pathway";"JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1";"Activation of the AP-1 family of transcription factors";"Oxidative Stress Induced Senescence"
XP_046422253.1	6	Reactome: R-HSA-76005;Reactome: R-HSA-416993;Reactome: R-HSA-114516;Reactome: R-HSA-418597;Reactome: R-HSA-5099900;KEGG: 04070+2.7.11.13	"Response to elevated platelet cytosolic Ca2+";"Trafficking of GluR2-containing AMPA receptors";"Disinhibition of SNARE formation";"G alpha (z) signalling events";"WNT5A-dependent internalization of FZD4";"Phosphatidylinositol signaling system"
XP_046409526.1	7	MetaCyc: PWY-7221;MetaCyc: PWY-5695;MetaCyc: PWY-6596;Reactome: R-HSA-6798695;Reactome: R-HSA-73817;KEGG: 00983+1.1.1.205;KEGG: 00230+1.1.1.205	"Guanosine ribonucleotides de novo biosynthesis";"Inosine 5'-phosphate degradation";"Adenosine nucleotides degradation I";"Neutrophil degranulation";"Purine ribonucleoside monophosphate biosynthesis";"Drug metabolism - other enzymes";"Purine metabolism"
XP_046419943.1	19	Reactome: R-HSA-6802952;Reactome: R-HSA-9649948;Reactome: R-HSA-3371571;Reactome: R-HSA-442982;Reactome: R-HSA-6802955;Reactome: R-HSA-9620244;Reactome: R-HSA-5673000;Reactome: R-HSA-6802946;Reactome: R-HSA-5673001;Reactome: R-HSA-9609736;Reactome: R-HSA-399719;Reactome: R-HSA-5578775;Reactome: R-HSA-936837;Reactome: R-HSA-9617324;Reactome: R-HSA-5576892;Reactome: R-HSA-877300;Reactome: R-HSA-9022692;Reactome: R-HSA-111932;Reactome: R-HSA-438066	"Signaling by BRAF and RAF fusions";"Signaling downstream of RAS mutants";"HSF1-dependent transactivation";"Ras activation upon Ca2+ influx through NMDA receptor";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"Long-term potentiation";"RAF activation";"Signaling by moderate kinase activity BRAF mutants";"RAF/MAP kinase cascade";"Assembly and cell surface presentation of NMDA receptors";"Trafficking of AMPA receptors";"Ion homeostasis";"Ion transport by P-type ATPases";"Negative regulation of NMDA receptor-mediated neuronal transmission";"Phase 0 - rapid depolarisation";"Interferon gamma signaling";"Regulation of MECP2 expression and activity";"CaMK IV-mediated phosphorylation of CREB";"Unblocking of NMDA receptors, glutamate binding and activation"
XP_046416973.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046418843.1	3	Reactome: R-HSA-8876725;Reactome: R-HSA-2514859;KEGG: 00310+2.1.1.60	"Protein methylation";"Inactivation, recovery and regulation of the phototransduction cascade";"Lysine degradation"
XP_046432775.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_046429791.1	19	Reactome: R-HSA-975957;Reactome: R-HSA-156902;Reactome: R-HSA-72649;Reactome: R-HSA-72764;Reactome: R-HSA-72689;Reactome: R-HSA-192823;Reactome: R-HSA-72695;Reactome: R-HSA-1799339;Reactome: R-HSA-3214858;Reactome: R-HSA-6790901;Reactome: R-HSA-6791226;Reactome: R-HSA-975956;Reactome: R-HSA-72702;Reactome: R-HSA-9633012;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-72706;Reactome: R-HSA-2408557;Reactome: R-HSA-8876725	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Peptide chain elongation";"Translation initiation complex formation";"Eukaryotic Translation Termination";"Formation of a pool of free 40S subunits";"Viral mRNA Translation";"Formation of the ternary complex, and subsequently, the 43S complex";"SRP-dependent cotranslational protein targeting to membrane";"RMTs methylate histone arginines";"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Ribosomal scanning and start codon recognition";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Selenocysteine synthesis";"Protein methylation"
XP_046433231.1	3	MetaCyc: PWY-6482;Reactome: R-HSA-5358493;MetaCyc: PWY-7546	"Diphthamide biosynthesis I (archaea)";"Synthesis of diphthamide-EEF2";"Diphthamide biosynthesis II (eukaryotes)"
XP_046413535.1	1	Reactome: R-HSA-1632852	"Macroautophagy"
XP_046421183.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046428611.1	2	Reactome: R-HSA-379726;KEGG: 00970+6.1.1.4	"Mitochondrial tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis"
XP_046409974.1	2	Reactome: R-HSA-8939243;Reactome: R-HSA-3214858	"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RMTs methylate histone arginines"
XP_046422980.1	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
XP_046430188.1	2	Reactome: R-HSA-2032785;Reactome: R-HSA-8951671	"YAP1- and WWTR1 (TAZ)-stimulated gene expression";"RUNX3 regulates YAP1-mediated transcription"
XP_046425044.1	2	Reactome: R-HSA-190873;Reactome: R-HSA-399719	"Gap junction degradation";"Trafficking of AMPA receptors"
XP_046411660.1	2	Reactome: R-HSA-1169408;Reactome: R-HSA-168276	"ISG15 antiviral mechanism";"NS1 Mediated Effects on Host Pathways"
XP_046415413.1	1	Reactome: R-HSA-5689880	"Ub-specific processing proteases"
XP_046423131.1	3	Reactome: R-HSA-6785470;Reactome: R-HSA-6784531;Reactome: R-HSA-8868766	"tRNA processing in the mitochondrion";"tRNA processing in the nucleus";"rRNA processing in the mitochondrion"
XP_046433931.1	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276	"Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination"
XP_046414697.1	2	Reactome: R-HSA-418594;Reactome: R-HSA-375276	"G alpha (i) signalling events";"Peptide ligand-binding receptors"
XP_046436330.1	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
XP_046428546.1	2	Reactome: R-HSA-6804756;Reactome: R-HSA-8854518	"Regulation of TP53 Activity through Phosphorylation";"AURKA Activation by TPX2"
XP_046411550.1	4	KEGG: 00750+1.4.3.5;MetaCyc: PWY-7282;Reactome: R-HSA-964975;MetaCyc: PWY-7204	"Vitamin B6 metabolism";"4-amino-2-methyl-5-phosphomethylpyrimidine biosynthesis";"Vitamins B6 activation to pyridoxal phosphate";"Pyridoxal 5'-phosphate salvage II (plants)"
XP_046427617.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_046419070.1	1	Reactome: R-HSA-5658442	"Regulation of RAS by GAPs"
XP_046427981.1	14	Reactome: R-HSA-426486;Reactome: R-HSA-8934593;Reactome: R-HSA-9018519;Reactome: R-HSA-4086398;Reactome: R-HSA-8986944;Reactome: R-HSA-1912408;Reactome: R-HSA-8943723;Reactome: R-HSA-5628897;Reactome: R-HSA-8948700;Reactome: R-HSA-9022692;Reactome: R-HSA-203927;Reactome: R-HSA-5687128;Reactome: R-HSA-426496;Reactome: R-HSA-9029569	"Small interfering RNA (siRNA) biogenesis";"Regulation of RUNX1 Expression and Activity";"Estrogen-dependent gene expression";"Ca2+ pathway";"Transcriptional Regulation by MECP2";"Pre-NOTCH Transcription and Translation";"Regulation of PTEN mRNA translation";"TP53 Regulates Metabolic Genes";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"Regulation of MECP2 expression and activity";"MicroRNA (miRNA) biogenesis";"MAPK6/MAPK4 signaling";"Post-transcriptional silencing by small RNAs";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux"
XP_046417545.1	2	Reactome: R-HSA-6798695;Reactome: R-HSA-936837	"Neutrophil degranulation";"Ion transport by P-type ATPases"
XP_046415702.1	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046424832.1	3	KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16	"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
XP_046436396.1	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_046416858.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_046412983.1	1	Reactome: R-HSA-112126	"ALKBH3 mediated reversal of alkylation damage"
XP_046418724.1	16	Reactome: R-HSA-167287;Reactome: R-HSA-180585;Reactome: R-HSA-1234176;Reactome: R-HSA-8951664;Reactome: R-HSA-167246;Reactome: R-HSA-167238;Reactome: R-HSA-6796648;Reactome: R-HSA-167200;Reactome: R-HSA-674695;Reactome: R-HSA-167152;Reactome: R-HSA-167290;Reactome: R-HSA-75955;Reactome: R-HSA-983168;Reactome: R-HSA-167243;Reactome: R-HSA-9010553;Reactome: R-HSA-112382	"HIV elongation arrest and recovery";"Vif-mediated degradation of APOBEC3G";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Neddylation";"Tat-mediated elongation of the HIV-1 transcript";"Pausing and recovery of Tat-mediated HIV elongation";"TP53 Regulates Transcription of DNA Repair Genes";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Polymerase II Pre-transcription Events";"Formation of HIV elongation complex in the absence of HIV Tat";"Pausing and recovery of HIV elongation";"RNA Polymerase II Transcription Elongation";"Antigen processing: Ubiquitination & Proteasome degradation";"Tat-mediated HIV elongation arrest and recovery";"Regulation of expression of SLITs and ROBOs";"Formation of RNA Pol II elongation complex"
XP_046431643.1	2	Reactome: R-HSA-380270;Reactome: R-HSA-380320	"Recruitment of mitotic centrosome proteins and complexes";"Recruitment of NuMA to mitotic centrosomes"
XP_046418839.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_046430250.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046411539.1	7	KEGG: 04070+3.1.3.25;Reactome: R-HSA-1855183;KEGG: 00562+3.1.3.25;KEGG: 00521+3.1.3.25;MetaCyc: PWY-6363;MetaCyc: PWY-4702;MetaCyc: PWY-2301	"Phosphatidylinositol signaling system";"Synthesis of IP2, IP, and Ins in the cytosol";"Inositol phosphate metabolism";"Streptomycin biosynthesis";"D-myo-inositol (1,4,5)-trisphosphate degradation";"Phytate degradation I";"Myo-inositol biosynthesis"
XP_046434112.1	1	Reactome: R-HSA-1474228	"Degradation of the extracellular matrix"
XP_046425269.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046434430.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_046431708.1	5	Reactome: R-HSA-376172;Reactome: R-HSA-168638;Reactome: R-HSA-171007;KEGG: 04150+2.7.11.24;Reactome: R-HSA-4420097	"DSCAM interactions";"NOD1/2 Signaling Pathway";"p38MAPK events";"mTOR signaling pathway";"VEGFA-VEGFR2 Pathway"
XP_046412930.1	1	Reactome: R-HSA-1483166	"Synthesis of PA"
XP_046435155.1	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_046417354.1	8	Reactome: R-HSA-9619483;Reactome: R-HSA-2151209;Reactome: R-HSA-1445148;Reactome: R-HSA-380972;Reactome: R-HSA-1632852;Reactome: R-HSA-5628897;Reactome: R-HSA-9613354;Reactome: R-HSA-6804756	"Activation of AMPK downstream of NMDARs";"Activation of PPARGC1A (PGC-1alpha) by phosphorylation";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Energy dependent regulation of mTOR by LKB1-AMPK";"Macroautophagy";"TP53 Regulates Metabolic Genes";"Lipophagy";"Regulation of TP53 Activity through Phosphorylation"
XP_046429727.1	5	Reactome: R-HSA-446199;KEGG: 00510+1.3.1.94;Reactome: R-HSA-193048;MetaCyc: PWY-6129;Reactome: R-HSA-4755579	"Synthesis of Dolichyl-phosphate";"N-Glycan biosynthesis";"Androgen biosynthesis";"Dolichol and dolichyl phosphate biosynthesis";"Defective SRD5A3 causes SRD5A3-CDG (CDG-1q) and KHRZ"
XP_046422517.1	6	Reactome: R-HSA-9648025;Reactome: R-HSA-141444;Reactome: R-HSA-68877;Reactome: R-HSA-2467813;Reactome: R-HSA-5663220;Reactome: R-HSA-2500257	"EML4 and NUDC in mitotic spindle formation";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Mitotic Prometaphase";"Separation of Sister Chromatids";"RHO GTPases Activate Formins";"Resolution of Sister Chromatid Cohesion"
XP_046430830.1	1	Reactome: R-HSA-203927	"MicroRNA (miRNA) biogenesis"
XP_046410552.1	6	Reactome: R-HSA-450385;Reactome: R-HSA-6791226;Reactome: R-HSA-380994;Reactome: R-HSA-429958;Reactome: R-HSA-450513;Reactome: R-HSA-450604	"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"Major pathway of rRNA processing in the nucleolus and cytosol";"ATF4 activates genes in response to endoplasmic reticulum stress";"mRNA decay by 3' to 5' exoribonuclease";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"KSRP (KHSRP) binds and destabilizes mRNA"
XP_046432734.1	7	Reactome: R-HSA-380320;Reactome: R-HSA-380270;Reactome: R-HSA-2565942;Reactome: R-HSA-8854518;Reactome: R-HSA-380259;Reactome: R-HSA-5620912;Reactome: R-HSA-380284	"Recruitment of NuMA to mitotic centrosomes";"Recruitment of mitotic centrosome proteins and complexes";"Regulation of PLK1 Activity at G2/M Transition";"AURKA Activation by TPX2";"Loss of Nlp from mitotic centrosomes";"Anchoring of the basal body to the plasma membrane";"Loss of proteins required for interphase microtubule organization from the centrosome"
XP_046425691.1	18	KEGG: 00330+2.6.1.1;KEGG: 00220+2.6.1.1;KEGG: 00250+2.6.1.1;MetaCyc: PWY-7117;KEGG: 00270+2.6.1.1;KEGG: 00960+2.6.1.1;KEGG: 00710+2.6.1.1;KEGG: 00350+2.6.1.1;MetaCyc: PWY-6643;MetaCyc: PWY-7115;KEGG: 00360+2.6.1.1;MetaCyc: PWY-6642;KEGG: 00950+2.6.1.1;MetaCyc: PWY-7383;MetaCyc: PWY-5913;MetaCyc: PWY-6638;KEGG: 00400+2.6.1.1;KEGG: 00401+2.6.1.1	"Arginine and proline metabolism";"Arginine biosynthesis";"Alanine, aspartate and glutamate metabolism";"C4 photosynthetic carbon assimilation cycle, PEPCK type";"Cysteine and methionine metabolism";"Tropane, piperidine and pyridine alkaloid biosynthesis";"Carbon fixation in photosynthetic organisms";"Tyrosine metabolism";"Coenzyme M biosynthesis II";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"Phenylalanine metabolism";"(R)-cysteate degradation";"Isoquinoline alkaloid biosynthesis";"Anaerobic energy metabolism (invertebrates, cytosol)";"Partial TCA cycle (obligate autotrophs)";"Sulfolactate degradation III";"Phenylalanine, tyrosine and tryptophan biosynthesis";"Novobiocin biosynthesis"
XP_046421629.1	3	KEGG: 04070+2.7.4.24+2.7.4.21;MetaCyc: PWY-6369;Reactome: R-HSA-1855167	"Phosphatidylinositol signaling system";"Inositol diphosphates biosynthesis";"Synthesis of pyrophosphates in the cytosol"
XP_046410460.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046423420.1	1	Reactome: R-HSA-4551638	"SUMOylation of chromatin organization proteins"
XP_046419019.1	2	Reactome: R-HSA-1433557;KEGG: 04660+2.7.10.2	"Signaling by SCF-KIT";"T cell receptor signaling pathway"
XP_046431047.1	3	Reactome: R-HSA-416476;Reactome: R-HSA-375276;Reactome: R-HSA-418594	"G alpha (q) signalling events";"Peptide ligand-binding receptors";"G alpha (i) signalling events"
XP_046433654.1	8	MetaCyc: PWY-6174;Reactome: R-HSA-1989781;MetaCyc: PWY-7391;MetaCyc: PWY-922;Reactome: R-HSA-191273;MetaCyc: PWY-7524;KEGG: 00900+1.1.1.34;Reactome: R-HSA-2426168	"Mevalonate pathway II (archaea)";"PPARA activates gene expression";"Isoprene biosynthesis II (engineered)";"Mevalonate pathway I";"Cholesterol biosynthesis";"Mevalonate pathway III (archaea)";"Terpenoid backbone biosynthesis";"Activation of gene expression by SREBF (SREBP)"
XP_046435497.1	2	Reactome: R-HSA-2243919;Reactome: R-HSA-1566948	"Crosslinking of collagen fibrils";"Elastic fibre formation"
XP_046428457.1	18	MetaCyc: PWY-7783;MetaCyc: PWY-6803;Reactome: R-HSA-1482925;KEGG: 00564+3.1.1.4;KEGG: 00591+3.1.1.4;Reactome: R-HSA-1482839;MetaCyc: PWY-8053;MetaCyc: PWY-7416;MetaCyc: PWY-7409;KEGG: 00592+3.1.1.4;Reactome: R-HSA-1483166;KEGG: 00590+3.1.1.4;Reactome: R-HSA-1482788;KEGG: 00565+3.1.1.4;Reactome: R-HSA-1482922;MetaCyc: PWY-8051;MetaCyc: PWY-7417;Reactome: R-HSA-1482801	"Plasmalogen degradation";"Phosphatidylcholine acyl editing";"Acyl chain remodelling of PG";"Glycerophospholipid metabolism";"Linoleic acid metabolism";"Acyl chain remodelling of PE";"Anandamide biosynthesis II";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"alpha-Linolenic acid metabolism";"Synthesis of PA";"Arachidonic acid metabolism";"Acyl chain remodelling of PC";"Ether lipid metabolism";"Acyl chain remodelling of PI";"Anandamide biosynthesis I";"Phospholipid remodeling (phosphatidate, yeast)";"Acyl chain remodelling of PS"
XP_046410015.1	1	Reactome: R-HSA-2022928	"HS-GAG biosynthesis"
XP_046436716.1	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
XP_046423659.1	1	Reactome: R-HSA-419037	"NCAM1 interactions"
XP_046421029.1	6	MetaCyc: PWY-7782;MetaCyc: PWY-5884;KEGG: 00073+1.2.1.84;MetaCyc: PWY-7656;Reactome: R-HSA-9640463;MetaCyc: PWY-6733	"Plasmalogen biosynthesis";"Wax esters biosynthesis I";"Cutin, suberine and wax biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Wax biosynthesis";"Sporopollenin precursors biosynthesis"
XP_046413194.1	4	KEGG: 00240+2.7.1.48;MetaCyc: PWY-7193;KEGG: 00983+2.7.1.48;Reactome: R-HSA-73614	"Pyrimidine metabolism";"Pyrimidine ribonucleosides salvage I";"Drug metabolism - other enzymes";"Pyrimidine salvage"
XP_046433242.1	1	Reactome: R-HSA-3295583	"TRP channels"
XP_046434739.1	2	MetaCyc: PWY-6854;Reactome: R-HSA-3299685	"Ethylene biosynthesis III (microbes)";"Detoxification of Reactive Oxygen Species"
XP_046418271.1	7	Reactome: R-HSA-5663220;Reactome: R-HSA-2500257;Reactome: R-HSA-68877;Reactome: R-HSA-2467813;Reactome: R-HSA-9648025;Reactome: R-HSA-141444;Reactome: R-HSA-5626467	"RHO GTPases Activate Formins";"Resolution of Sister Chromatid Cohesion";"Mitotic Prometaphase";"Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"RHO GTPases activate IQGAPs"
XP_046427150.1	2	Reactome: R-HSA-8949613;Reactome: R-HSA-163210	"Cristae formation";"Formation of ATP by chemiosmotic coupling"
XP_046425015.1	2	Reactome: R-HSA-936440;Reactome: R-HSA-5689896	"Negative regulators of DDX58/IFIH1 signaling";"Ovarian tumor domain proteases"
XP_046417306.1	12	MetaCyc: PWY-801;Reactome: R-HSA-71240;MetaCyc: PWY-7901;MetaCyc: PWY-601;MetaCyc: PWY-6309;KEGG: 00380+2.6.1.7;KEGG: 00450+4.4.1.13;MetaCyc: PWY-2821;MetaCyc: PWY-6842;KEGG: 00270+4.4.1.13;MetaCyc: PWY-6936;MetaCyc: PWY-1187	"Homocysteine and cysteine interconversion";"Tryptophan catabolism";"Glucosinolate biosynthesis from tyrosine";"Glucosinolate biosynthesis from tryptophan";"L-tryptophan degradation XI (mammalian, via kynurenine)";"Tryptophan metabolism";"Selenocompound metabolism";"Glucosinolate biosynthesis from phenylalanine";"Glutathione-mediated detoxification II";"Cysteine and methionine metabolism";"Seleno-amino acid biosynthesis (plants)";"Glucosinolate biosynthesis from homomethionine"
XP_046412657.1	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
XP_046419069.1	1	Reactome: R-HSA-5658442	"Regulation of RAS by GAPs"
XP_046429310.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046416662.1	6	Reactome: R-HSA-4641265;Reactome: R-HSA-201722;Reactome: R-HSA-8951430;Reactome: R-HSA-4411364;Reactome: R-HSA-4086398;Reactome: R-HSA-3769402	"Repression of WNT target genes";"Formation of the beta-catenin:TCF transactivating complex";"RUNX3 regulates WNT signaling";"Binding of TCF/LEF:CTNNB1 to target gene promoters";"Ca2+ pathway";"Deactivation of the beta-catenin transactivating complex"
XP_046421047.1	5	MetaCyc: PWY-5084;KEGG: 00310+1.2.4.2;KEGG: 00380+1.2.4.2;Reactome: R-HSA-389661;KEGG: 00020+1.2.4.2	"2-oxoglutarate decarboxylation to succinyl-CoA";"Lysine degradation";"Tryptophan metabolism";"Glyoxylate metabolism and glycine degradation";"Citrate cycle (TCA cycle)"
XP_046427015.1	1	Reactome: R-HSA-2022928	"HS-GAG biosynthesis"
XP_046431676.1	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
XP_046432083.1	7	KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1	"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Human cytomegalovirus infection";"Thermogenesis";"Relaxin signaling pathway";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection"
XP_046414893.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_046422748.1	1	Reactome: R-HSA-156584	"Cytosolic sulfonation of small molecules"
XP_046413296.1	4	Reactome: R-HSA-201681;Reactome: R-HSA-5689880;Reactome: R-HSA-418594;Reactome: R-HSA-4641257	"TCF dependent signaling in response to WNT";"Ub-specific processing proteases";"G alpha (i) signalling events";"Degradation of AXIN"
XP_046426522.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-5628897	"Respiratory electron transport";"TP53 Regulates Metabolic Genes"
XP_046424774.1	7	Reactome: R-HSA-2470946;Reactome: R-HSA-2500257;Reactome: R-HSA-1221632;Reactome: R-HSA-9018519;Reactome: R-HSA-2467813;Reactome: R-HSA-3108214;Reactome: R-HSA-2468052	"Cohesin Loading onto Chromatin";"Resolution of Sister Chromatid Cohesion";"Meiotic synapsis";"Estrogen-dependent gene expression";"Separation of Sister Chromatids";"SUMOylation of DNA damage response and repair proteins";"Establishment of Sister Chromatid Cohesion"
XP_046419409.1	7	MetaCyc: PWY-5074;KEGG: 00280+4.1.3.4;KEGG: 00281+4.1.3.4;KEGG: 00650+4.1.3.4;KEGG: 00072+4.1.3.4;Reactome: R-HSA-77111;Reactome: R-HSA-9033241	"Mevalonate degradation";"Valine, leucine and isoleucine degradation";"Geraniol degradation";"Butanoate metabolism";"Synthesis and degradation of ketone bodies";"Synthesis of Ketone Bodies";"Peroxisomal protein import"
XP_046428741.1	13	Reactome: R-HSA-72706;Reactome: R-HSA-2408557;Reactome: R-HSA-1799339;Reactome: R-HSA-72689;Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-192823;Reactome: R-HSA-156902;Reactome: R-HSA-975956;Reactome: R-HSA-72764;Reactome: R-HSA-975957;Reactome: R-HSA-6791226	"GTP hydrolysis and joining of the 60S ribosomal subunit";"Selenocysteine synthesis";"SRP-dependent cotranslational protein targeting to membrane";"Formation of a pool of free 40S subunits";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Viral mRNA Translation";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046423373.1	7	KEGG: 00195+7.1.2.2;KEGG: 00190+7.1.2.2;MetaCyc: PWY-7980;Reactome: R-HSA-1268020;Reactome: R-HSA-2151201;Reactome: R-HSA-163210;Reactome: R-HSA-8949613	"Photosynthesis";"Oxidative phosphorylation";"ATP biosynthesis";"Mitochondrial protein import";"Transcriptional activation of mitochondrial biogenesis";"Formation of ATP by chemiosmotic coupling";"Cristae formation"
XP_046413294.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046420158.1	1	Reactome: R-HSA-5666185	"RHO GTPases Activate Rhotekin and Rhophilins"
XP_046436397.1	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
XP_046411279.1	3	Reactome: R-HSA-6807878;Reactome: R-HSA-6811440;Reactome: R-HSA-6811438	"COPI-mediated anterograde transport";"Retrograde transport at the Trans-Golgi-Network";"Intra-Golgi traffic"
XP_046431291.1	1	Reactome: R-HSA-426117	"Cation-coupled Chloride cotransporters"
XP_046424956.1	5	Reactome: R-HSA-427413;Reactome: R-HSA-73863;Reactome: R-HSA-73772;Reactome: R-HSA-5250924;Reactome: R-HSA-73762	"NoRC negatively regulates rRNA expression";"RNA Polymerase I Transcription Termination";"RNA Polymerase I Promoter Escape";"B-WICH complex positively regulates rRNA expression";"RNA Polymerase I Transcription Initiation"
XP_046420092.1	16	Reactome: R-HSA-975957;Reactome: R-HSA-72764;Reactome: R-HSA-72649;Reactome: R-HSA-156902;Reactome: R-HSA-192823;Reactome: R-HSA-72689;Reactome: R-HSA-1799339;Reactome: R-HSA-72695;Reactome: R-HSA-6791226;Reactome: R-HSA-975956;Reactome: R-HSA-72702;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-2408557;Reactome: R-HSA-72706	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Translation initiation complex formation";"Peptide chain elongation";"Viral mRNA Translation";"Formation of a pool of free 40S subunits";"SRP-dependent cotranslational protein targeting to membrane";"Formation of the ternary complex, and subsequently, the 43S complex";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Ribosomal scanning and start codon recognition";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Selenocysteine synthesis";"GTP hydrolysis and joining of the 60S ribosomal subunit"
XP_046425824.1	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
XP_046426967.1	10	KEGG: 04714+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04660+2.7.10.2;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1;Reactome: R-HSA-5357956;KEGG: 04150+2.7.11.1;Reactome: R-HSA-5357905	"Thermogenesis";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"T cell receptor signaling pathway";"Human cytomegalovirus infection";"Relaxin signaling pathway";"PI3K-Akt signaling pathway";"TNFR1-induced NFkappaB signaling pathway";"mTOR signaling pathway";"Regulation of TNFR1 signaling"
XP_046425306.1	9	Reactome: R-HSA-75955;Reactome: R-HSA-6807505;Reactome: R-HSA-2173796;Reactome: R-HSA-112382;Reactome: R-HSA-167287;Reactome: R-HSA-6796648;Reactome: R-HSA-674695;Reactome: R-HSA-167152;Reactome: R-HSA-167290	"RNA Polymerase II Transcription Elongation";"RNA polymerase II transcribes snRNA genes";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"Formation of RNA Pol II elongation complex";"HIV elongation arrest and recovery";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase II Pre-transcription Events";"Formation of HIV elongation complex in the absence of HIV Tat";"Pausing and recovery of HIV elongation"
XP_046413540.1	2	KEGG: 00500+3.2.1.28;Reactome: R-HSA-189085	"Starch and sucrose metabolism";"Digestion of dietary carbohydrate"
XP_046417579.1	12	Reactome: R-HSA-6804756;Reactome: R-HSA-167152;Reactome: R-HSA-167290;Reactome: R-HSA-167287;Reactome: R-HSA-6796648;Reactome: R-HSA-167200;Reactome: R-HSA-674695;Reactome: R-HSA-167238;Reactome: R-HSA-167243;Reactome: R-HSA-112382;Reactome: R-HSA-167246;Reactome: R-HSA-75955	"Regulation of TP53 Activity through Phosphorylation";"Formation of HIV elongation complex in the absence of HIV Tat";"Pausing and recovery of HIV elongation";"HIV elongation arrest and recovery";"TP53 Regulates Transcription of DNA Repair Genes";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Polymerase II Pre-transcription Events";"Pausing and recovery of Tat-mediated HIV elongation";"Tat-mediated HIV elongation arrest and recovery";"Formation of RNA Pol II elongation complex";"Tat-mediated elongation of the HIV-1 transcript";"RNA Polymerase II Transcription Elongation"
XP_046425891.1	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
XP_046422628.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
XP_046420662.1	2	Reactome: R-HSA-380270;Reactome: R-HSA-380320	"Recruitment of mitotic centrosome proteins and complexes";"Recruitment of NuMA to mitotic centrosomes"
XP_046421249.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046410737.1	4	Reactome: R-HSA-5576893;Reactome: R-HSA-419037;Reactome: R-HSA-5576892;Reactome: R-HSA-112308	"Phase 2 - plateau phase";"NCAM1 interactions";"Phase 0 - rapid depolarisation";"Presynaptic depolarization and calcium channel opening"
XP_046411626.1	2	Reactome: R-HSA-3238698;Reactome: R-HSA-373080	"WNT ligand biogenesis and trafficking";"Class B/2 (Secretin family receptors)"
XP_046418834.1	1	Reactome: R-HSA-83936	"Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"
XP_046424095.1	24	Reactome: R-HSA-163359;Reactome: R-HSA-9009391;Reactome: R-HSA-4086398;Reactome: R-HSA-392170;Reactome: R-HSA-8964616;Reactome: R-HSA-418217;Reactome: R-HSA-6814122;Reactome: R-HSA-392451;Reactome: R-HSA-418594;Reactome: R-HSA-202040;Reactome: R-HSA-456926;Reactome: R-HSA-418592;Reactome: R-HSA-416482;Reactome: R-HSA-418597;Reactome: R-HSA-416476;Reactome: R-HSA-392851;Reactome: R-HSA-418555;Reactome: R-HSA-400042;Reactome: R-HSA-500657;Reactome: R-HSA-432040;Reactome: R-HSA-8964315;Reactome: R-HSA-428930;Reactome: R-HSA-420092;Reactome: R-HSA-381676	"Glucagon signaling in metabolic regulation";"Extra-nuclear estrogen signaling";"Ca2+ pathway";"ADP signalling through P2Y purinoceptor 12";"G beta:gamma signalling through CDC42";"G beta:gamma signalling through PLC beta";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"G beta:gamma signalling through PI3Kgamma";"G alpha (i) signalling events";"G-protein activation";"Thrombin signalling through proteinase activated receptors (PARs)";"ADP signalling through P2Y purinoceptor 1";"G alpha (12/13) signalling events";"G alpha (z) signalling events";"G alpha (q) signalling events";"Prostacyclin signalling through prostacyclin receptor";"G alpha (s) signalling events";"Adrenaline,noradrenaline inhibits insulin secretion";"Presynaptic function of Kainate receptors";"Vasopressin regulates renal water homeostasis via Aquaporins";"G beta:gamma signalling through BTK";"Thromboxane signalling through TP receptor";"Glucagon-type ligand receptors";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion"
XP_046412843.1	1	Reactome: R-HSA-216083	"Integrin cell surface interactions"
XP_046415106.1	11	KEGG: 00230+1.17.1.4;MetaCyc: PWY-5497;MetaCyc: PWY-6596;MetaCyc: PWY-6999;MetaCyc: PWY-6606;MetaCyc: PWY-6608;MetaCyc: PWY-5695;Reactome: R-HSA-74259;MetaCyc: PWY-6538;MetaCyc: PWY-6607;Reactome: R-HSA-8851680	"Purine metabolism";"Purine nucleobases degradation II (anaerobic)";"Adenosine nucleotides degradation I";"Theophylline degradation";"Guanosine nucleotides degradation II";"Guanosine nucleotides degradation III";"Inosine 5'-phosphate degradation";"Purine catabolism";"Caffeine degradation III (bacteria, via demethylation)";"Guanosine nucleotides degradation I";"Butyrophilin (BTN) family interactions"
XP_046409586.1	1	Reactome: R-HSA-1362409	"Mitochondrial iron-sulfur cluster biogenesis"
XP_046414189.1	1	Reactome: R-HSA-1660662	"Glycosphingolipid metabolism"
XP_046430185.1	2	Reactome: R-HSA-2032785;Reactome: R-HSA-8951671	"YAP1- and WWTR1 (TAZ)-stimulated gene expression";"RUNX3 regulates YAP1-mediated transcription"
XP_046410040.1	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
XP_046411060.1	7	Reactome: R-HSA-2979096;Reactome: R-HSA-2691232;Reactome: R-HSA-2660826;Reactome: R-HSA-2894862;Reactome: R-HSA-2122948;Reactome: R-HSA-2644606;Reactome: R-HSA-9013507	"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Constitutive Signaling by NOTCH1 HD Domain Mutants";"Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Activated NOTCH1 Transmits Signal to the Nucleus";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH3 Activation and Transmission of Signal to the Nucleus"
XP_046434996.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046417605.1	2	Reactome: R-HSA-6807878;Reactome: R-HSA-6811434	"COPI-mediated anterograde transport";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_046420988.1	1	Reactome: R-HSA-1655829	"Regulation of cholesterol biosynthesis by SREBP (SREBF)"
XP_046413188.1	2	KEGG: 00620+3.6.1.7;KEGG: 00627+3.6.1.7	"Pyruvate metabolism";"Aminobenzoate degradation"
XP_046427183.1	11	Reactome: R-HSA-2559580;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;Reactome: R-HSA-171007;KEGG: 05163+2.7.11.1;Reactome: R-HSA-4420097;Reactome: R-HSA-450302;KEGG: 04926+2.7.11.1	"Oxidative Stress Induced Senescence";"Thermogenesis";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"PI3K-Akt signaling pathway";"mTOR signaling pathway";"p38MAPK events";"Human cytomegalovirus infection";"VEGFA-VEGFR2 Pathway";"activated TAK1 mediates p38 MAPK activation";"Relaxin signaling pathway"
XP_046412426.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_046431575.1	6	MetaCyc: PWY-5381;MetaCyc: PWY-7761;Reactome: R-HSA-196807;KEGG: 00760+6.3.5.1;KEGG: 00760+6.3.1.5;MetaCyc: PWY-5653	"Pyridine nucleotide cycling (plants)";"NAD salvage pathway II (PNC IV cycle)";"Nicotinate metabolism";"Nicotinate and nicotinamide metabolism";"Nicotinate and nicotinamide metabolism";"NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde"
XP_046422708.1	1	Reactome: R-HSA-425561	"Sodium/Calcium exchangers"
XP_046420747.1	2	Reactome: R-HSA-70895;KEGG: 00280+1.3.8.4	"Branched-chain amino acid catabolism";"Valine, leucine and isoleucine degradation"
XP_046420810.1	5	Reactome: R-HSA-380994;Reactome: R-HSA-9648895;Reactome: R-HSA-9633012;Reactome: R-HSA-8963693;KEGG: 00250+6.3.5.4	"ATF4 activates genes in response to endoplasmic reticulum stress";"Response of EIF2AK1 (HRI) to heme deficiency";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Aspartate and asparagine metabolism";"Alanine, aspartate and glutamate metabolism"
XP_046415767.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_046417535.1	2	Reactome: R-HSA-6798695;Reactome: R-HSA-936837	"Neutrophil degranulation";"Ion transport by P-type ATPases"
XP_046412537.1	2	Reactome: R-HSA-983231;Reactome: R-HSA-5205685	"Factors involved in megakaryocyte development and platelet production";"Pink/Parkin Mediated Mitophagy"
XP_046412592.1	1	Reactome: R-HSA-419771	"Opsins"
XP_046424294.1	2	Reactome: R-HSA-5628897;Reactome: R-HSA-611105	"TP53 Regulates Metabolic Genes";"Respiratory electron transport"
XP_046428647.1	1	Reactome: R-HSA-525793	"Myogenesis"
XP_046433125.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_046410707.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_046429937.1	3	Reactome: R-HSA-2022854;Reactome: R-HSA-5083627;Reactome: R-HSA-5173105	"Keratan sulfate biosynthesis";"Defective LARGE causes MDDGA6 and MDDGB6";"O-linked glycosylation"
XP_046430372.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046419843.1	3	KEGG: 00730+3.1.3.2;KEGG: 00740+3.1.3.2;MetaCyc: PWY-6348	"Thiamine metabolism";"Riboflavin metabolism";"Phosphate acquisition"
XP_046410925.1	14	MetaCyc: PWY-7725;MetaCyc: PWY-7619;MetaCyc: PWY-7601;KEGG: 00062+2.3.1.199;MetaCyc: PWY-5080;MetaCyc: PWY-6598;MetaCyc: PWY-7036;MetaCyc: PWY-7602;MetaCyc: PWY-8041;MetaCyc: PWY-7035;MetaCyc: PWY-6433;MetaCyc: PWY-5972;Reactome: R-HSA-75876;MetaCyc: PWY-7724	"Arachidonate biosynthesis V (8-detaturase, mammals)";"Juniperonate biosynthesis";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Fatty acid elongation";"Very long chain fatty acid biosynthesis I";"Sciadonate biosynthesis";"Very long chain fatty acid biosynthesis II";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Ultra-long-chain fatty acid biosynthesis";"(9Z)-tricosene biosynthesis";"Hydroxylated fatty acid biosynthesis (plants)";"Stearate biosynthesis I (animals)";"Synthesis of very long-chain fatty acyl-CoAs";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)"
XP_046409702.1	5	Reactome: R-HSA-6798695;Reactome: R-HSA-8856825;Reactome: R-HSA-6811440;Reactome: R-HSA-432722;Reactome: R-HSA-8856828	"Neutrophil degranulation";"Cargo recognition for clathrin-mediated endocytosis";"Retrograde transport at the Trans-Golgi-Network";"Golgi Associated Vesicle Biogenesis";"Clathrin-mediated endocytosis"
XP_046427119.1	1	Reactome: R-HSA-111465	"Apoptotic cleavage of cellular proteins"
XP_046414989.1	8	Reactome: R-HSA-983712;Reactome: R-HSA-917977;Reactome: R-HSA-1222556;Reactome: R-HSA-167590;Reactome: R-HSA-9636467;Reactome: R-HSA-182218;Reactome: R-HSA-9639288;Reactome: R-HSA-77387	"Ion channel transport";"Transferrin endocytosis and recycling";"ROS and RNS production in phagocytes";"Nef Mediated CD4 Down-regulation";"Blockage of phagosome acidification";"Nef Mediated CD8 Down-regulation";"Amino acids regulate mTORC1";"Insulin receptor recycling"
XP_046429412.1	1	Reactome: R-HSA-5625900	"RHO GTPases activate CIT"
XP_046416633.1	7	Reactome: R-HSA-5368598;Reactome: R-HSA-201688;Reactome: R-HSA-201681;Reactome: R-HSA-4641262;Reactome: R-HSA-4641258;Reactome: R-HSA-5663220;Reactome: R-HSA-4086400	"Negative regulation of TCF-dependent signaling by DVL-interacting proteins";"WNT mediated activation of DVL";"TCF dependent signaling in response to WNT";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"Degradation of DVL";"RHO GTPases Activate Formins";"PCP/CE pathway"
XP_046429648.1	5	MetaCyc: PWY-7426;KEGG: 00513+2.4.1.68;KEGG: 00533+2.4.1.68;KEGG: 00510+2.4.1.68;Reactome: R-HSA-975578	"Complex N-linked glycan biosynthesis (vertebrates)";"Various types of N-glycan biosynthesis";"Glycosaminoglycan biosynthesis - keratan sulfate";"N-Glycan biosynthesis";"Reactions specific to the complex N-glycan synthesis pathway"
XP_046425969.1	1	Reactome: R-HSA-176974	"Unwinding of DNA"
XP_046430880.1	6	KEGG: 04070+2.7.1.107;KEGG: 00564+2.7.1.107;Reactome: R-HSA-114508;MetaCyc: PWY-7817;MetaCyc: PWY-7039;KEGG: 00561+2.7.1.107	"Phosphatidylinositol signaling system";"Glycerophospholipid metabolism";"Effects of PIP2 hydrolysis";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Phosphatidate metabolism, as a signaling molecule";"Glycerolipid metabolism"
XP_046410857.1	4	Reactome: R-HSA-73856;Reactome: R-HSA-72163;Reactome: R-HSA-159236;Reactome: R-HSA-72187	"RNA Polymerase II Transcription Termination";"mRNA Splicing - Major Pathway";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"mRNA 3'-end processing"
XP_046420721.1	14	MetaCyc: PWY-5080;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7601;MetaCyc: PWY-7619;MetaCyc: PWY-7725;MetaCyc: PWY-7035;MetaCyc: PWY-8041;MetaCyc: PWY-7036;MetaCyc: PWY-6598;MetaCyc: PWY-7602;MetaCyc: PWY-6433;MetaCyc: PWY-7724;MetaCyc: PWY-5972;Reactome: R-HSA-75876	"Very long chain fatty acid biosynthesis I";"Fatty acid elongation";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Juniperonate biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"(9Z)-tricosene biosynthesis";"Ultra-long-chain fatty acid biosynthesis";"Very long chain fatty acid biosynthesis II";"Sciadonate biosynthesis";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Hydroxylated fatty acid biosynthesis (plants)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Stearate biosynthesis I (animals)";"Synthesis of very long-chain fatty acyl-CoAs"
XP_046419392.1	31	Reactome: R-HSA-163765;MetaCyc: PWY-5971;MetaCyc: PWY-6519;MetaCyc: PWY-7663;MetaCyc: PWY-6113;MetaCyc: PWY-5994;MetaCyc: PWY-5989;MetaCyc: PWY-5147;MetaCyc: PWY-7746;MetaCyc: PWY-7723;MetaCyc: PWY-7858;Reactome: R-HSA-9029558;MetaCyc: PWY-6282;Reactome: R-HSA-75105;MetaCyc: PWY-5973;KEGG: 00061+1.1.1.100+2.3.1.85+4.2.1.59+2.3.1.39+2.3.1.41+3.1.2.14;MetaCyc: PWY-8047;MetaCyc: PWY-5366;MetaCyc: PWY-7664;MetaCyc: PWY-5142;MetaCyc: PWY-5367;KEGG: 00780+1.1.1.100+4.2.1.59+2.3.1.41;Reactome: R-HSA-199220;MetaCyc: PWY-8012;MetaCyc: PWY-8049;MetaCyc: PWYG-321;Reactome: R-HSA-2426168;MetaCyc: PWY-6799;MetaCyc: PWY-4381;MetaCyc: PWY-7388;MetaCyc: PWY-5966-1	"ChREBP activates metabolic gene expression";"Palmitate biosynthesis II (bacteria and plant cytoplasm)";"8-amino-7-oxononanoate biosynthesis I";"Gondoate biosynthesis (anaerobic)";"Superpathway of mycolate biosynthesis";"Palmitate biosynthesis (animals and fungi, cytoplasm)";"Stearate biosynthesis II (bacteria and plants)";"Oleate biosynthesis I (plants)";"Mycobacterial sulfolipid biosynthesis";"Bacterial bioluminescence";"(5Z)-dodecenoate biosynthesis II";"NR1H2 & NR1H3 regulate gene expression linked to lipogenesis";"Palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate)";"Fatty acyl-CoA biosynthesis";"Cis-vaccenate biosynthesis";"Fatty acid biosynthesis";"Bryostatin biosynthesis";"Palmitoleate biosynthesis II (plants and bacteria)";"Oleate biosynthesis IV (anaerobic)";"Acyl-[acyl-carrier protein] thioesterase pathway";"Petroselinate biosynthesis";"Biotin metabolism";"Vitamin B5 (pantothenate) metabolism";"Mupirocin biosynthesis";"Pederin biosynthesis";"";"Activation of gene expression by SREBF (SREBP)";"Fatty acid biosynthesis initiation (plant mitochondria)";"Fatty acid biosynthesis initiation (bacteria and plants)";"Octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast)";"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)"
XP_046410897.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_046411564.1	1	Reactome: R-HSA-429947	"Deadenylation of mRNA"
XP_046427003.1	1	Reactome: R-HSA-5689880	"Ub-specific processing proteases"
XP_046414332.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046416960.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046433507.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_046422082.1	3	Reactome: R-HSA-193648;Reactome: R-HSA-194840;Reactome: R-HSA-416482	"NRAGE signals death through JNK";"Rho GTPase cycle";"G alpha (12/13) signalling events"
XP_046429436.1	1	Reactome: R-HSA-1632852	"Macroautophagy"
XP_046418831.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046418809.1	3	Reactome: R-HSA-72163;Reactome: R-HSA-5250924;Reactome: R-HSA-72165	"mRNA Splicing - Major Pathway";"B-WICH complex positively regulates rRNA expression";"mRNA Splicing - Minor Pathway"
XP_046434879.1	2	Reactome: R-HSA-418555;Reactome: R-HSA-444821	"G alpha (s) signalling events";"Relaxin receptors"
XP_046433275.1	7	MetaCyc: PWY-5084;KEGG: 00020+2.3.1.61;Reactome: R-HSA-71064;Reactome: R-HSA-71403;Reactome: R-HSA-389661;KEGG: 00310+2.3.1.61;KEGG: 00380+2.3.1.61	"2-oxoglutarate decarboxylation to succinyl-CoA";"Citrate cycle (TCA cycle)";"Lysine catabolism";"Citric acid cycle (TCA cycle)";"Glyoxylate metabolism and glycine degradation";"Lysine degradation";"Tryptophan metabolism"
XP_046422875.1	1	Reactome: R-HSA-6794361	"Neurexins and neuroligins"
XP_046426258.1	3	Reactome: R-HSA-6784531;MetaCyc: PWY-7803;MetaCyc: PWY-6689	"tRNA processing in the nucleus";"Trna splicing II";"Trna splicing I"
XP_046424581.1	2	MetaCyc: PWY-7851;KEGG: 00770+2.7.1.24	"Coenzyme A biosynthesis II (eukaryotic)";"Pantothenate and CoA biosynthesis"
XP_046415777.1	2	Reactome: R-HSA-8866907;Reactome: R-HSA-8866904	"Activation of the TFAP2 (AP-2) family of transcription factors";"Negative regulation of activity of TFAP2 (AP-2) family transcription factors"
XP_046419993.1	3	Reactome: R-HSA-5579007;KEGG: 00220+3.5.1.14;Reactome: R-HSA-5423646	"Defective ACY1 causes encephalopathy";"Arginine biosynthesis";"Aflatoxin activation and detoxification"
XP_046427755.1	1	Reactome: R-HSA-1614517	"Sulfide oxidation to sulfate"
XP_046427279.1	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
XP_046412702.1	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
XP_046421006.1	1	Reactome: R-HSA-432047	"Passive transport by Aquaporins"
XP_046409935.1	6	Reactome: R-HSA-73930;Reactome: R-HSA-110357;Reactome: R-HSA-5651801;Reactome: R-HSA-110373;Reactome: R-HSA-73933;Reactome: R-HSA-110362	"Abasic sugar-phosphate removal via the single-nucleotide replacement pathway";"Displacement of DNA glycosylase by APEX1";"PCNA-Dependent Long Patch Base Excision Repair";"Resolution of AP sites via the multiple-nucleotide patch replacement pathway";"Resolution of Abasic Sites (AP sites)";"POLB-Dependent Long Patch Base Excision Repair"
XP_046414793.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_046420549.1	3	Reactome: R-HSA-8939236;Reactome: R-HSA-383280;Reactome: R-HSA-983231	"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Nuclear Receptor transcription pathway";"Factors involved in megakaryocyte development and platelet production"
XP_046431388.1	3	Reactome: R-HSA-6785470;Reactome: R-HSA-6787450;Reactome: R-HSA-8868766	"tRNA processing in the mitochondrion";"tRNA modification in the mitochondrion";"rRNA processing in the mitochondrion"
XP_046420160.1	1	Reactome: R-HSA-5666185	"RHO GTPases Activate Rhotekin and Rhophilins"
XP_046425241.1	57	Reactome: R-HSA-5668541;Reactome: R-HSA-8941858;Reactome: R-HSA-9010553;Reactome: R-HSA-350562;Reactome: R-HSA-1236974;Reactome: R-HSA-5610780;Reactome: R-HSA-450408;Reactome: R-HSA-5632684;Reactome: R-HSA-211733;Reactome: R-HSA-4641258;Reactome: R-HSA-382556;Reactome: R-HSA-68949;Reactome: R-HSA-1169091;Reactome: R-HSA-2871837;Reactome: R-HSA-174178;Reactome: R-HSA-195253;Reactome: R-HSA-69601;Reactome: R-HSA-69017;Reactome: R-HSA-5358346;Reactome: R-HSA-9604323;Reactome: R-HSA-5362768;Reactome: R-HSA-5676590;Reactome: R-HSA-174113;Reactome: R-HSA-5687128;Reactome: R-HSA-8854050;Reactome: R-HSA-9020702;Reactome: R-HSA-1234176;Reactome: R-HSA-8948751;Reactome: R-HSA-69481;Reactome: R-HSA-8852276;Reactome: R-HSA-5610783;Reactome: R-HSA-5689603;Reactome: R-HSA-68827;Reactome: R-HSA-5607764;Reactome: R-HSA-187577;Reactome: R-HSA-180534;Reactome: R-HSA-6798695;Reactome: R-HSA-5607761;Reactome: R-HSA-5658442;Reactome: R-HSA-983168;Reactome: R-HSA-2467813;Reactome: R-HSA-174154;Reactome: R-HSA-174184;Reactome: R-HSA-8939902;Reactome: R-HSA-1236978;Reactome: R-HSA-4641257;Reactome: R-HSA-4608870;Reactome: R-HSA-75815;Reactome: R-HSA-202424;Reactome: R-HSA-5689880;Reactome: R-HSA-174084;Reactome: R-HSA-8951664;Reactome: R-HSA-349425;Reactome: R-HSA-8939236;Reactome: R-HSA-5678895;Reactome: R-HSA-180585;Reactome: R-HSA-5610785	"TNFR2 non-canonical NF-kB pathway";"Regulation of RUNX3 expression and activity";"Regulation of expression of SLITs and ROBOs";"Regulation of ornithine decarboxylase (ODC)";"ER-Phagosome pathway";"Degradation of GLI1 by the proteasome";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Hedgehog 'on' state";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Degradation of DVL";"ABC-family proteins mediated transport";"Orc1 removal from chromatin";"Activation of NF-kappaB in B cells";"FCERI mediated NF-kB activation";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Degradation of beta-catenin by the destruction complex";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"CDK-mediated phosphorylation and removal of Cdc6";"Hedgehog ligand biogenesis";"Negative regulation of NOTCH4 signaling";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"NIK-->noncanonical NF-kB signaling";"SCF-beta-TrCP mediated degradation of Emi1";"MAPK6/MAPK4 signaling";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Interleukin-1 signaling";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of PTEN stability and activity";"G2/M Checkpoints";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Degradation of GLI2 by the proteasome";"UCH proteinases";"CDT1 association with the CDC6:ORC:origin complex";"CLEC7A (Dectin-1) signaling";"SCF(Skp2)-mediated degradation of p27/p21";"Vpu mediated degradation of CD4";"Neutrophil degranulation";"Dectin-1 mediated noncanonical NF-kB signaling";"Regulation of RAS by GAPs";"Antigen processing: Ubiquitination & Proteasome degradation";"Separation of Sister Chromatids";"APC/C:Cdc20 mediated degradation of Securin";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Regulation of RUNX2 expression and activity";"Cross-presentation of soluble exogenous antigens (endosomes)";"Degradation of AXIN";"Asymmetric localization of PCP proteins";"Ubiquitin-dependent degradation of Cyclin D";"Downstream TCR signaling";"Ub-specific processing proteases";"Autodegradation of Cdh1 by Cdh1:APC/C";"Neddylation";"Autodegradation of the E3 ubiquitin ligase COP1";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Defective CFTR causes cystic fibrosis";"Vif-mediated degradation of APOBEC3G";"GLI3 is processed to GLI3R by the proteasome"
XP_046421180.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046434398.1	2	Reactome: R-HSA-72163;Reactome: R-HSA-430039	"mRNA Splicing - Major Pathway";"mRNA decay by 5' to 3' exoribonuclease"
XP_046419532.1	3	KEGG: 00970+6.1.1.14;Reactome: R-HSA-379726;Reactome: R-HSA-379716	"Aminoacyl-tRNA biosynthesis";"Mitochondrial tRNA aminoacylation";"Cytosolic tRNA aminoacylation"
XP_046409581.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
XP_046421390.1	3	Reactome: R-HSA-203615;KEGG: 00790+1.1.1.153;Reactome: R-HSA-1474151	"eNOS activation";"Folate biosynthesis";"Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation"
XP_046410411.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046417125.1	2	Reactome: R-HSA-390471;Reactome: R-HSA-1660662	"Association of TriC/CCT with target proteins during biosynthesis";"Glycosphingolipid metabolism"
XP_046415500.1	3	Reactome: R-HSA-9609690;Reactome: R-HSA-3899300;Reactome: R-HSA-6804757	"HCMV Early Events";"SUMOylation of transcription cofactors";"Regulation of TP53 Degradation"
XP_046432458.1	4	MetaCyc: PWY-5189;KEGG: 00860+4.2.1.75;Reactome: R-HSA-189451;MetaCyc: PWY-5188	"Tetrapyrrole biosynthesis II (from glycine)";"Porphyrin and chlorophyll metabolism";"Heme biosynthesis";"Tetrapyrrole biosynthesis I (from glutamate)"
XP_046414510.1	2	Reactome: R-HSA-1483115;Reactome: R-HSA-1483152	"Hydrolysis of LPC";"Hydrolysis of LPE"
XP_046418273.1	7	Reactome: R-HSA-9648025;Reactome: R-HSA-5626467;Reactome: R-HSA-141444;Reactome: R-HSA-68877;Reactome: R-HSA-2467813;Reactome: R-HSA-5663220;Reactome: R-HSA-2500257	"EML4 and NUDC in mitotic spindle formation";"RHO GTPases activate IQGAPs";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Mitotic Prometaphase";"Separation of Sister Chromatids";"RHO GTPases Activate Formins";"Resolution of Sister Chromatid Cohesion"
XP_046426172.1	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_046420670.1	2	KEGG: 00230+2.7.6.1;KEGG: 00030+2.7.6.1	"Purine metabolism";"Pentose phosphate pathway"
XP_046428362.1	11	MetaCyc: PWY-7821;MetaCyc: PWY-7206;KEGG: 00770+3.6.1.9;KEGG: 00240+3.6.1.9;MetaCyc: PWY-6545;MetaCyc: PWY-7187;MetaCyc: PWY-7184;KEGG: 00740+3.6.1.9;KEGG: 00230+3.6.1.9;KEGG: 00500+3.6.1.9;KEGG: 00760+3.6.1.9	"Tunicamycin biosynthesis";"Pyrimidine deoxyribonucleotides dephosphorylation";"Pantothenate and CoA biosynthesis";"Pyrimidine metabolism";"Pyrimidine deoxyribonucleotides de novo biosynthesis III";"Pyrimidine deoxyribonucleotides de novo biosynthesis II";"Pyrimidine deoxyribonucleotides de novo biosynthesis I";"Riboflavin metabolism";"Purine metabolism";"Starch and sucrose metabolism";"Nicotinate and nicotinamide metabolism"
XP_046424058.1	7	Reactome: R-HSA-9639288;Reactome: R-HSA-8943724;Reactome: R-HSA-165159;Reactome: R-HSA-380972;Reactome: R-HSA-5628897;Reactome: R-HSA-166208;Reactome: R-HSA-1632852	"Amino acids regulate mTORC1";"Regulation of PTEN gene transcription";"mTOR signalling";"Energy dependent regulation of mTOR by LKB1-AMPK";"TP53 Regulates Metabolic Genes";"mTORC1-mediated signalling";"Macroautophagy"
XP_046413233.1	7	KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1	"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Relaxin signaling pathway";"Thermogenesis";"Human cytomegalovirus infection";"mTOR signaling pathway";"PI3K-Akt signaling pathway"
XP_046435425.1	3	Reactome: R-HSA-75109;KEGG: 00561+2.7.1.30;MetaCyc: PWY-4261	"Triglyceride biosynthesis";"Glycerolipid metabolism";"Glycerol degradation I"
XP_046413814.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046431493.1	3	KEGG: 00970+6.1.1.19;Reactome: R-HSA-379716;Reactome: R-HSA-2408522	"Aminoacyl-tRNA biosynthesis";"Cytosolic tRNA aminoacylation";"Selenoamino acid metabolism"
XP_046423710.1	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
XP_046422146.1	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
XP_046427206.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046431387.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046426002.1	2	Reactome: R-HSA-8866654;MetaCyc: PWY-7511	"E3 ubiquitin ligases ubiquitinate target proteins";"Protein ubiquitination"
XP_046435348.1	1	Reactome: R-HSA-389957	"Prefoldin mediated transfer of substrate to CCT/TriC"
XP_046418334.1	1	Reactome: R-HSA-611105	"Respiratory electron transport"
XP_046430496.1	1	Reactome: R-HSA-427359	"SIRT1 negatively regulates rRNA expression"
XP_046426554.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_046433571.1	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
XP_046418222.1	3	KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation"
XP_046409524.1	7	Reactome: R-HSA-6798695;MetaCyc: PWY-7221;MetaCyc: PWY-6596;MetaCyc: PWY-5695;KEGG: 00230+1.1.1.205;KEGG: 00983+1.1.1.205;Reactome: R-HSA-73817	"Neutrophil degranulation";"Guanosine ribonucleotides de novo biosynthesis";"Adenosine nucleotides degradation I";"Inosine 5'-phosphate degradation";"Purine metabolism";"Drug metabolism - other enzymes";"Purine ribonucleoside monophosphate biosynthesis"
XP_046418191.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046435879.1	3	Reactome: R-HSA-6807878;Reactome: R-HSA-8963901;Reactome: R-HSA-445095	"COPI-mediated anterograde transport";"Chylomicron remodeling";"Interaction between L1 and Ankyrins"
XP_046433386.1	3	Reactome: R-HSA-194840;Reactome: R-HSA-416482;Reactome: R-HSA-193648	"Rho GTPase cycle";"G alpha (12/13) signalling events";"NRAGE signals death through JNK"
XP_046422544.1	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
XP_046428674.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046412056.1	3	Reactome: R-HSA-6811434;Reactome: R-HSA-983189;Reactome: R-HSA-390471	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins";"Association of TriC/CCT with target proteins during biosynthesis"
XP_046426133.1	10	MetaCyc: PWY-6362;KEGG: 00562+2.7.1.158;MetaCyc: PWY-6554;Reactome: R-HSA-1855191;MetaCyc: PWY-6361;Reactome: R-HSA-1855167;MetaCyc: PWY-6372;MetaCyc: PWY-4661;KEGG: 04070+2.7.1.158;MetaCyc: PWY-6369	"1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)";"Inositol phosphate metabolism";"1D-myo-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3)";"Synthesis of IPs in the nucleus";"1D-myo-inositol hexakisphosphate biosynthesis I (from Ins(1,4,5)P3)";"Synthesis of pyrophosphates in the cytosol";"1D-myo-inositol hexakisphosphate biosynthesis IV (Dictyostelium)";"1D-myo-inositol hexakisphosphate biosynthesis III (Spirodela polyrrhiza)";"Phosphatidylinositol signaling system";"Inositol diphosphates biosynthesis"
XP_046427371.1	1	Reactome: R-HSA-1660661	"Sphingolipid de novo biosynthesis"
XP_046427562.1	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
XP_046419011.1	10	KEGG: 00480+2.3.2.2+3.4.19.13;MetaCyc: PWY-7559;MetaCyc: PWY-6842;MetaCyc: PWY-5826;MetaCyc: PWY-8001;KEGG: 00460+2.3.2.2;MetaCyc: PWY-4041;MetaCyc: PWY-7112;MetaCyc: PWY-4061;KEGG: 00430+2.3.2.2	"Glutathione metabolism";"Glutathione degradation (DUG pathway";"Glutathione-mediated detoxification II";"Hypoglycin biosynthesis";"Felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis";"Cyanoamino acid metabolism";"Gamma-glutamyl cycle";"4-hydroxy-2-nonenal detoxification";"Glutathione-mediated detoxification I";"Taurine and hypotaurine metabolism"
XP_046436626.1	1	Reactome: R-HSA-5601884	"PIWI-interacting RNA (piRNA) biogenesis"
XP_046435798.1	1	Reactome: R-HSA-196843	"Vitamin B2 (riboflavin) metabolism"
XP_046436735.1	3	Reactome: R-HSA-3899300;Reactome: R-HSA-3232118;Reactome: R-HSA-4090294	"SUMOylation of transcription cofactors";"SUMOylation of transcription factors";"SUMOylation of intracellular receptors"
XP_046432534.1	5	KEGG: 00603+3.2.1.22;MetaCyc: PWY-6527;KEGG: 00052+3.2.1.22;KEGG: 00600+3.2.1.22;KEGG: 00561+3.2.1.22	"Glycosphingolipid biosynthesis - globo and isoglobo series";"Stachyose degradation";"Galactose metabolism";"Sphingolipid metabolism";"Glycerolipid metabolism"
XP_046423228.1	3	MetaCyc: PWY-7174;MetaCyc: PWY-4361;KEGG: 00270+5.3.1.23	"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation II";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I";"Cysteine and methionine metabolism"
XP_046420621.1	1	Reactome: R-HSA-2132295	"MHC class II antigen presentation"
XP_046413591.1	10	KEGG: 00051+2.7.1.11;KEGG: 00052+2.7.1.11;KEGG: 00030+2.7.1.11;MetaCyc: PWY-1042;MetaCyc: PWY-7385;KEGG: 00680+2.7.1.11;MetaCyc: PWY-5484;Reactome: R-HSA-70171;KEGG: 00010+2.7.1.11;MetaCyc: PWY-1861	"Fructose and mannose metabolism";"Galactose metabolism";"Pentose phosphate pathway";"Glycolysis IV (plant cytosol)";"1,3-propanediol biosynthesis (engineered)";"Methane metabolism";"Glycolysis II (from fructose 6-phosphate)";"Glycolysis";"Glycolysis / Gluconeogenesis";"Formaldehyde assimilation II (assimilatory RuMP Cycle)"
XP_046421058.1	4	Reactome: R-HSA-2132295;Reactome: R-HSA-983189;Reactome: R-HSA-5625970;Reactome: R-HSA-6811434	"MHC class II antigen presentation";"Kinesins";"RHO GTPases activate KTN1";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_046419927.1	8	MetaCyc: PWY-7979;KEGG: 00515+2.4.1.109;Reactome: R-HSA-5083633;Reactome: R-HSA-5173105;Reactome: R-HSA-5083629;MetaCyc: PWY-7922;MetaCyc: PWY-7921;KEGG: 00514+2.4.1.109	"Protein O-mannosylation III (mammals, core M3)";"Mannose type O-glycan biosynthesis";"Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1";"O-linked glycosylation";"Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2";"Protein O-mannosylation II (mammals, core M1 and core M2)";"Protein O-mannosylation I (yeast)";"Other types of O-glycan biosynthesis"
XP_046414153.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_046415783.1	2	KEGG: 00970+6.1.1.20;Reactome: R-HSA-379726	"Aminoacyl-tRNA biosynthesis";"Mitochondrial tRNA aminoacylation"
XP_046432107.1	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
XP_046430061.1	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286	"Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation"
XP_046422658.1	4	Reactome: R-HSA-72187;Reactome: R-HSA-159236;Reactome: R-HSA-72163;Reactome: R-HSA-73856	"mRNA 3'-end processing";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"mRNA Splicing - Major Pathway";"RNA Polymerase II Transcription Termination"
XP_046410602.1	1	Reactome: R-HSA-6799198	"Complex I biogenesis"
XP_046420232.1	10	Reactome: R-HSA-9022699;Reactome: R-HSA-3899300;Reactome: R-HSA-9022538;Reactome: R-HSA-9022692;Reactome: R-HSA-427413;Reactome: R-HSA-983231;Reactome: R-HSA-8936459;Reactome: R-HSA-9022702;Reactome: R-HSA-9615017;Reactome: R-HSA-400206	"MECP2 regulates neuronal receptors and channels";"SUMOylation of transcription cofactors";"Loss of MECP2 binding ability to 5mC-DNA";"Regulation of MECP2 expression and activity";"NoRC negatively regulates rRNA expression";"Factors involved in megakaryocyte development and platelet production";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"MECP2 regulates transcription of neuronal ligands";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"Regulation of lipid metabolism by PPARalpha"
XP_046417733.1	2	Reactome: R-HSA-202733;Reactome: R-HSA-416993	"Cell surface interactions at the vascular wall";"Trafficking of GluR2-containing AMPA receptors"
XP_046418415.1	2	Reactome: R-HSA-6783310;Reactome: R-HSA-6796648	"Fanconi Anemia Pathway";"TP53 Regulates Transcription of DNA Repair Genes"
XP_046426804.1	1	Reactome: R-HSA-3214858	"RMTs methylate histone arginines"
XP_046428177.1	7	MetaCyc: PWY-882;KEGG: 00520+5.4.2.8;MetaCyc: PWY-7586;Reactome: R-HSA-446205;MetaCyc: PWY-5659;KEGG: 00051+5.4.2.8;MetaCyc: PWY-7456	"L-ascorbate biosynthesis I (L-galactose pathway)";"Amino sugar and nucleotide sugar metabolism";"Beta-1,4-d-mannosyl-n-acetyl-d-glucosamine degradation";"Synthesis of GDP-mannose";"GDP-mannose biosynthesis";"Fructose and mannose metabolism";"Beta-(1,4)-mannan degradation"
XP_046409975.1	2	Reactome: R-HSA-8939243;Reactome: R-HSA-3214858	"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RMTs methylate histone arginines"
XP_046412073.1	4	Reactome: R-HSA-499943;KEGG: 00230+2.7.4.3;MetaCyc: PWY-7219;KEGG: 00730+2.7.4.3	"Interconversion of nucleotide di- and triphosphates";"Purine metabolism";"Adenosine ribonucleotides de novo biosynthesis";"Thiamine metabolism"
XP_046412417.1	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046413928.1	4	Reactome: R-HSA-8856825;Reactome: R-HSA-5696394;Reactome: R-HSA-8951664;Reactome: R-HSA-6781823	"Cargo recognition for clathrin-mediated endocytosis";"DNA Damage Recognition in GG-NER";"Neddylation";"Formation of TC-NER Pre-Incision Complex"
XP_046419477.1	5	Reactome: R-HSA-77595;Reactome: R-HSA-73856;Reactome: R-HSA-72163;Reactome: R-HSA-72187;Reactome: R-HSA-6784531	"Processing of Intronless Pre-mRNAs";"RNA Polymerase II Transcription Termination";"mRNA Splicing - Major Pathway";"mRNA 3'-end processing";"tRNA processing in the nucleus"
XP_046418739.1	2	Reactome: R-HSA-390471;Reactome: R-HSA-1660662	"Association of TriC/CCT with target proteins during biosynthesis";"Glycosphingolipid metabolism"
XP_046414114.1	1	Reactome: R-HSA-6811440	"Retrograde transport at the Trans-Golgi-Network"
XP_046411289.1	1	Reactome: R-HSA-446203	"Asparagine N-linked glycosylation"
XP_046413131.1	8	Reactome: R-HSA-1855183;MetaCyc: PWY-6580;MetaCyc: PWY-6664;KEGG: 00521+5.5.1.4;MetaCyc: PWY-2301;MetaCyc: PWY-6372;KEGG: 00562+5.5.1.4;MetaCyc: PWY-4661	"Synthesis of IP2, IP, and Ins in the cytosol";"Phosphatidylinositol biosynthesis I (bacteria)";"Di-myo-inositol phosphate biosynthesis";"Streptomycin biosynthesis";"Myo-inositol biosynthesis";"1D-myo-inositol hexakisphosphate biosynthesis IV (Dictyostelium)";"Inositol phosphate metabolism";"1D-myo-inositol hexakisphosphate biosynthesis III (Spirodela polyrrhiza)"
XP_046414508.1	2	Reactome: R-HSA-1483115;Reactome: R-HSA-1483152	"Hydrolysis of LPC";"Hydrolysis of LPE"
XP_046410100.1	7	MetaCyc: PWY-7294;MetaCyc: PWY-7854;MetaCyc: PWY-7118;KEGG: 00630+2.3.3.9;KEGG: 00620+2.3.3.9;MetaCyc: PWY-6969;MetaCyc: PWY-7295	"D-xylose degradation IV";"Crotonyl-coa/ethylmalonyl-coa/hydroxybutyryl-coa cycle (engineered)";"Chitin degradation to ethanol";"Glyoxylate and dicarboxylate metabolism";"Pyruvate metabolism";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"L-arabinose degradation IV"
XP_046435578.1	6	KEGG: 00520+2.7.7.12;MetaCyc: PWY-6527;KEGG: 00052+2.7.7.12;Reactome: R-HSA-5609978;MetaCyc: PWY-6317;Reactome: R-HSA-70370	"Amino sugar and nucleotide sugar metabolism";"Stachyose degradation";"Galactose metabolism";"Defective GALT can cause Galactosemia";"D-galactose degradation I (Leloir pathway)";"Galactose catabolism"
XP_046423446.1	1	Reactome: R-HSA-9617828	"FOXO-mediated transcription of cell cycle genes"
XP_046426494.1	7	KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1	"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Relaxin signaling pathway";"Thermogenesis";"Human cytomegalovirus infection"
XP_046411428.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046431880.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046435661.1	2	Reactome: R-HSA-5628897;Reactome: R-HSA-611105	"TP53 Regulates Metabolic Genes";"Respiratory electron transport"
XP_046434079.1	1	Reactome: R-HSA-1296061	"HCN channels"
XP_046431339.1	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
XP_046436388.1	1	Reactome: R-HSA-162791	"Attachment of GPI anchor to uPAR"
XP_046411261.1	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046417806.1	5	Reactome: R-HSA-1266695;Reactome: R-HSA-8939243;Reactome: R-HSA-201722;Reactome: R-HSA-3247509;Reactome: R-HSA-3214858	"Interleukin-7 signaling";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"Formation of the beta-catenin:TCF transactivating complex";"Chromatin modifying enzymes";"RMTs methylate histone arginines"
XP_046416091.1	2	Reactome: R-HSA-203927;Reactome: R-HSA-8986944	"MicroRNA (miRNA) biogenesis";"Transcriptional Regulation by MECP2"
XP_046427723.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_046435381.1	2	Reactome: R-HSA-8856828;Reactome: R-HSA-8856825	"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis"
XP_046426797.1	3	Reactome: R-HSA-9609523;Reactome: R-HSA-1236974;Reactome: R-HSA-1799339	"Insertion of tail-anchored proteins into the endoplasmic reticulum membrane";"ER-Phagosome pathway";"SRP-dependent cotranslational protein targeting to membrane"
XP_046418194.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046417960.1	1	Reactome: R-HSA-428890	"Role of ABL in ROBO-SLIT signaling"
XP_046419601.1	7	MetaCyc: PWY-7818;MetaCyc: PWY-7782;KEGG: 00564+2.7.1.32+2.7.1.82;MetaCyc: PWY-7886;Reactome: R-HSA-1483213;MetaCyc: PWY-3385;Reactome: R-HSA-1483191	"Type IV lipoteichoic acid biosynthesis (S. pneumoniae)";"Plasmalogen biosynthesis";"Glycerophospholipid metabolism";"Cell-surface glycoconjugate-linked phosphocholine biosynthesis";"Synthesis of PE";"Choline biosynthesis I";"Synthesis of PC"
XP_046410717.1	2	Reactome: R-HSA-977443;Reactome: R-HSA-1236394	"GABA receptor activation";"Signaling by ERBB4"
XP_046431969.1	4	Reactome: R-HSA-975957;Reactome: R-HSA-9010553;Reactome: R-HSA-975956;Reactome: R-HSA-72764	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Regulation of expression of SLITs and ROBOs";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination"
XP_046425909.1	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
XP_046434732.1	3	Reactome: R-HSA-418594;Reactome: R-HSA-375276;Reactome: R-HSA-416476	"G alpha (i) signalling events";"Peptide ligand-binding receptors";"G alpha (q) signalling events"
XP_046410842.1	1	Reactome: R-HSA-209968	"Thyroxine biosynthesis"
XP_046431377.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046423742.1	4	Reactome: R-HSA-4549349;KEGG: 00513+2.4.1.257+2.4.1.132;Reactome: R-HSA-446193;KEGG: 00510+2.4.1.257+2.4.1.132	"Defective ALG2 causes ALG2-CDG (CDG-1i)";"Various types of N-glycan biosynthesis";"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"N-Glycan biosynthesis"
XP_046410727.1	4	Reactome: R-HSA-112308;Reactome: R-HSA-419037;Reactome: R-HSA-5576892;Reactome: R-HSA-5576893	"Presynaptic depolarization and calcium channel opening";"NCAM1 interactions";"Phase 0 - rapid depolarisation";"Phase 2 - plateau phase"
XP_046423276.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046414182.1	3	MetaCyc: PWY-3961;KEGG: 00770+2.7.1.33;Reactome: R-HSA-196783	"Phosphopantothenate biosynthesis II";"Pantothenate and CoA biosynthesis";"Coenzyme A biosynthesis"
XP_046410697.1	16	Reactome: R-HSA-174048;Reactome: R-HSA-179409;Reactome: R-HSA-176412;Reactome: R-HSA-174084;Reactome: R-HSA-8853884;Reactome: R-HSA-176409;Reactome: R-HSA-176407;Reactome: R-HSA-174184;Reactome: R-HSA-176408;Reactome: R-HSA-174154;Reactome: R-HSA-69017;Reactome: R-HSA-2467813;Reactome: R-HSA-2559582;Reactome: R-HSA-174178;Reactome: R-HSA-983168;Reactome: R-HSA-141430	"APC/C:Cdc20 mediated degradation of Cyclin B";"APC-Cdc20 mediated degradation of Nek2A";"Phosphorylation of the APC/C";"Autodegradation of Cdh1 by Cdh1:APC/C";"Transcriptional Regulation by VENTX";"APC/C:Cdc20 mediated degradation of mitotic proteins";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Regulation of APC/C activators between G1/S and early anaphase";"APC/C:Cdc20 mediated degradation of Securin";"CDK-mediated phosphorylation and removal of Cdc6";"Separation of Sister Chromatids";"Senescence-Associated Secretory Phenotype (SASP)";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Antigen processing: Ubiquitination & Proteasome degradation";"Inactivation of APC/C via direct inhibition of the APC/C complex"
XP_046434624.1	13	Reactome: R-HSA-1799339;Reactome: R-HSA-2408557;Reactome: R-HSA-72706;Reactome: R-HSA-192823;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-72689;Reactome: R-HSA-9633012;Reactome: R-HSA-72764;Reactome: R-HSA-975956;Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-975957	"SRP-dependent cotranslational protein targeting to membrane";"Selenocysteine synthesis";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Formation of a pool of free 40S subunits";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
XP_046430382.1	5	Reactome: R-HSA-73856;Reactome: R-HSA-77595;Reactome: R-HSA-168315;Reactome: R-HSA-72163;Reactome: R-HSA-72187	"RNA Polymerase II Transcription Termination";"Processing of Intronless Pre-mRNAs";"Inhibition of Host mRNA Processing and RNA Silencing";"mRNA Splicing - Major Pathway";"mRNA 3'-end processing"
XP_046429291.1	2	Reactome: R-HSA-196780;Reactome: R-HSA-3371599	"Biotin transport and metabolism";"Defective HLCS causes multiple carboxylase deficiency"
XP_046414308.1	56	Reactome: R-HSA-1236978;Reactome: R-HSA-4608870;Reactome: R-HSA-4641257;Reactome: R-HSA-75815;Reactome: R-HSA-202424;Reactome: R-HSA-174084;Reactome: R-HSA-5689880;Reactome: R-HSA-8951664;Reactome: R-HSA-349425;Reactome: R-HSA-8939236;Reactome: R-HSA-180585;Reactome: R-HSA-5678895;Reactome: R-HSA-5610785;Reactome: R-HSA-5607761;Reactome: R-HSA-5658442;Reactome: R-HSA-983168;Reactome: R-HSA-2467813;Reactome: R-HSA-174154;Reactome: R-HSA-174184;Reactome: R-HSA-8939902;Reactome: R-HSA-174113;Reactome: R-HSA-5687128;Reactome: R-HSA-8854050;Reactome: R-HSA-9020702;Reactome: R-HSA-1234176;Reactome: R-HSA-8948751;Reactome: R-HSA-69481;Reactome: R-HSA-8852276;Reactome: R-HSA-5610783;Reactome: R-HSA-5689603;Reactome: R-HSA-68827;Reactome: R-HSA-5607764;Reactome: R-HSA-180534;Reactome: R-HSA-187577;Reactome: R-HSA-5668541;Reactome: R-HSA-350562;Reactome: R-HSA-9010553;Reactome: R-HSA-8941858;Reactome: R-HSA-1236974;Reactome: R-HSA-5610780;Reactome: R-HSA-450408;Reactome: R-HSA-5632684;Reactome: R-HSA-4641258;Reactome: R-HSA-211733;Reactome: R-HSA-382556;Reactome: R-HSA-1169091;Reactome: R-HSA-68949;Reactome: R-HSA-174178;Reactome: R-HSA-2871837;Reactome: R-HSA-195253;Reactome: R-HSA-5358346;Reactome: R-HSA-69017;Reactome: R-HSA-69601;Reactome: R-HSA-9604323;Reactome: R-HSA-5362768;Reactome: R-HSA-5676590	"Cross-presentation of soluble exogenous antigens (endosomes)";"Asymmetric localization of PCP proteins";"Degradation of AXIN";"Ubiquitin-dependent degradation of Cyclin D";"Downstream TCR signaling";"Autodegradation of Cdh1 by Cdh1:APC/C";"Ub-specific processing proteases";"Neddylation";"Autodegradation of the E3 ubiquitin ligase COP1";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Vif-mediated degradation of APOBEC3G";"Defective CFTR causes cystic fibrosis";"GLI3 is processed to GLI3R by the proteasome";"Dectin-1 mediated noncanonical NF-kB signaling";"Regulation of RAS by GAPs";"Antigen processing: Ubiquitination & Proteasome degradation";"Separation of Sister Chromatids";"APC/C:Cdc20 mediated degradation of Securin";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Regulation of RUNX2 expression and activity";"SCF-beta-TrCP mediated degradation of Emi1";"MAPK6/MAPK4 signaling";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Interleukin-1 signaling";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of PTEN stability and activity";"G2/M Checkpoints";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Degradation of GLI2 by the proteasome";"UCH proteinases";"CDT1 association with the CDC6:ORC:origin complex";"CLEC7A (Dectin-1) signaling";"Vpu mediated degradation of CD4";"SCF(Skp2)-mediated degradation of p27/p21";"TNFR2 non-canonical NF-kB pathway";"Regulation of ornithine decarboxylase (ODC)";"Regulation of expression of SLITs and ROBOs";"Regulation of RUNX3 expression and activity";"ER-Phagosome pathway";"Degradation of GLI1 by the proteasome";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Hedgehog 'on' state";"Degradation of DVL";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"ABC-family proteins mediated transport";"Activation of NF-kappaB in B cells";"Orc1 removal from chromatin";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"FCERI mediated NF-kB activation";"Degradation of beta-catenin by the destruction complex";"Hedgehog ligand biogenesis";"CDK-mediated phosphorylation and removal of Cdc6";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Negative regulation of NOTCH4 signaling";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"NIK-->noncanonical NF-kB signaling"
XP_046424415.1	3	Reactome: R-HSA-450385;Reactome: R-HSA-450513;Reactome: R-HSA-430039	"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"mRNA decay by 5' to 3' exoribonuclease"
XP_046418473.1	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
XP_046421982.1	2	Reactome: R-HSA-1296052;Reactome: R-HSA-418457	"Ca2+ activated K+ channels";"cGMP effects"
XP_046413465.1	4	KEGG: 00020+1.2.4.2;MetaCyc: PWY-5084;KEGG: 00310+1.2.4.2;KEGG: 00380+1.2.4.2	"Citrate cycle (TCA cycle)";"2-oxoglutarate decarboxylation to succinyl-CoA";"Lysine degradation";"Tryptophan metabolism"
XP_046415198.1	1	Reactome: R-HSA-420499	"Class C/3 (Metabotropic glutamate/pheromone receptors)"
XP_046431115.1	1	Reactome: R-HSA-6787450	"tRNA modification in the mitochondrion"
XP_046415376.1	1	Reactome: R-HSA-111957	"Cam-PDE 1 activation"
XP_046420803.1	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
XP_046435364.1	2	Reactome: R-HSA-8856828;Reactome: R-HSA-8856825	"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis"
XP_046417824.1	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840	"Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation"
XP_046428581.1	3	Reactome: R-HSA-193648;Reactome: R-HSA-194840;Reactome: R-HSA-416482	"NRAGE signals death through JNK";"Rho GTPase cycle";"G alpha (12/13) signalling events"
XP_046419162.1	9	Reactome: R-HSA-6802946;Reactome: R-HSA-6798695;Reactome: R-HSA-445355;Reactome: R-HSA-114608;Reactome: R-HSA-6802955;Reactome: R-HSA-5674135;Reactome: R-HSA-6802948;Reactome: R-HSA-6802952;Reactome: R-HSA-9649948	"Signaling by moderate kinase activity BRAF mutants";"Neutrophil degranulation";"Smooth Muscle Contraction";"Platelet degranulation";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"MAP2K and MAPK activation";"Signaling by high-kinase activity BRAF mutants";"Signaling by BRAF and RAF fusions";"Signaling downstream of RAS mutants"
XP_046412055.1	3	Reactome: R-HSA-6811434;Reactome: R-HSA-983189;Reactome: R-HSA-390471	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins";"Association of TriC/CCT with target proteins during biosynthesis"
XP_046434465.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046409301.1	3	MetaCyc: PWY-6619;Reactome: R-HSA-74217;KEGG: 00230+2.7.1.20	"Adenine and adenosine salvage VI";"Purine salvage";"Purine metabolism"
XP_046421996.1	2	Reactome: R-HSA-418457;Reactome: R-HSA-1296052	"cGMP effects";"Ca2+ activated K+ channels"
XP_046422594.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046434979.1	6	KEGG: 00240+2.4.2.10;MetaCyc: PWY-5686;Reactome: R-HSA-500753;KEGG: 00983+2.4.2.10;MetaCyc: PWY-7791;MetaCyc: PWY-7790	"Pyrimidine metabolism";"UMP biosynthesis I";"Pyrimidine biosynthesis";"Drug metabolism - other enzymes";"UMP biosynthesis III";"UMP biosynthesis II"
XP_046410328.1	6	KEGG: 00500+2.4.1.1;MetaCyc: PWY-5941;MetaCyc: PWY-6737;MetaCyc: PWY-6731;MetaCyc: PWY-7238;Reactome: R-HSA-70221	"Starch and sucrose metabolism";"Glycogen degradation II";"Starch degradation V";"Starch degradation III";"Sucrose biosynthesis II";"Glycogen breakdown (glycogenolysis)"
XP_046429831.1	8	KEGG: 00524+2.7.1.1;KEGG: 00500+2.7.1.1;KEGG: 00052+2.7.1.1;KEGG: 00521+2.7.1.1;Reactome: R-HSA-70171;KEGG: 00010+2.7.1.1;KEGG: 00051+2.7.1.1;KEGG: 00520+2.7.1.1	"Neomycin, kanamycin and gentamicin biosynthesis";"Starch and sucrose metabolism";"Galactose metabolism";"Streptomycin biosynthesis";"Glycolysis";"Glycolysis / Gluconeogenesis";"Fructose and mannose metabolism";"Amino sugar and nucleotide sugar metabolism"
XP_046431118.1	2	Reactome: R-HSA-445355;Reactome: R-HSA-390522	"Smooth Muscle Contraction";"Striated Muscle Contraction"
XP_046420707.1	14	MetaCyc: PWY-7725;MetaCyc: PWY-7619;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7601;MetaCyc: PWY-5080;MetaCyc: PWY-7602;MetaCyc: PWY-6598;MetaCyc: PWY-7036;MetaCyc: PWY-8041;MetaCyc: PWY-7035;MetaCyc: PWY-6433;Reactome: R-HSA-75876;MetaCyc: PWY-5972;MetaCyc: PWY-7724	"Arachidonate biosynthesis V (8-detaturase, mammals)";"Juniperonate biosynthesis";"Fatty acid elongation";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis I";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Sciadonate biosynthesis";"Very long chain fatty acid biosynthesis II";"Ultra-long-chain fatty acid biosynthesis";"(9Z)-tricosene biosynthesis";"Hydroxylated fatty acid biosynthesis (plants)";"Synthesis of very long-chain fatty acyl-CoAs";"Stearate biosynthesis I (animals)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)"
XP_046419587.1	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
XP_046425680.1	4	Reactome: R-HSA-6781823;Reactome: R-HSA-8951664;Reactome: R-HSA-5696394;Reactome: R-HSA-8856825	"Formation of TC-NER Pre-Incision Complex";"Neddylation";"DNA Damage Recognition in GG-NER";"Cargo recognition for clathrin-mediated endocytosis"
XP_046416852.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_046413514.1	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
XP_046428427.1	7	KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1	"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Relaxin signaling pathway";"Thermogenesis";"Human cytomegalovirus infection";"mTOR signaling pathway";"PI3K-Akt signaling pathway"
XP_046433351.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046424205.1	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840	"Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation"
XP_046418461.1	2	Reactome: R-HSA-5576892;Reactome: R-HSA-5576893	"Phase 0 - rapid depolarisation";"Phase 2 - plateau phase"
XP_046428300.1	2	Reactome: R-HSA-5339700;Reactome: R-HSA-4641265	"TCF7L2 mutants don't bind CTBP";"Repression of WNT target genes"
XP_046418188.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046435443.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046410505.1	7	Reactome: R-HSA-5578749;Reactome: R-HSA-180746;Reactome: R-HSA-203927;Reactome: R-HSA-165054;Reactome: R-HSA-1655829;Reactome: R-HSA-6784531;Reactome: R-HSA-168333	"Transcriptional regulation by small RNAs";"Nuclear import of Rev protein";"MicroRNA (miRNA) biogenesis";"Rev-mediated nuclear export of HIV RNA";"Regulation of cholesterol biosynthesis by SREBP (SREBF)";"tRNA processing in the nucleus";"NEP/NS2 Interacts with the Cellular Export Machinery"
XP_046412751.1	1	Reactome: R-HSA-2564830	"Cytosolic iron-sulfur cluster assembly"
XP_046430947.1	1	Reactome: R-HSA-8854691	"Interleukin-20 family signaling"
XP_046410927.1	14	MetaCyc: PWY-7601;KEGG: 00062+2.3.1.199;MetaCyc: PWY-5080;MetaCyc: PWY-7725;MetaCyc: PWY-7619;MetaCyc: PWY-7035;MetaCyc: PWY-7036;MetaCyc: PWY-6598;MetaCyc: PWY-7602;MetaCyc: PWY-8041;MetaCyc: PWY-6433;MetaCyc: PWY-5972;Reactome: R-HSA-75876;MetaCyc: PWY-7724	"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Fatty acid elongation";"Very long chain fatty acid biosynthesis I";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Juniperonate biosynthesis";"(9Z)-tricosene biosynthesis";"Very long chain fatty acid biosynthesis II";"Sciadonate biosynthesis";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Ultra-long-chain fatty acid biosynthesis";"Hydroxylated fatty acid biosynthesis (plants)";"Stearate biosynthesis I (animals)";"Synthesis of very long-chain fatty acyl-CoAs";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)"
XP_046420675.1	42	Reactome: R-HSA-110331;Reactome: R-HSA-427413;Reactome: R-HSA-2559580;Reactome: R-HSA-5693607;Reactome: R-HSA-3214858;Reactome: R-HSA-427389;Reactome: R-HSA-5250924;Reactome: R-HSA-3214847;Reactome: R-HSA-8939236;Reactome: R-HSA-606279;Reactome: R-HSA-3214842;Reactome: R-HSA-9616222;Reactome: R-HSA-3214815;Reactome: R-HSA-212300;Reactome: R-HSA-4551638;Reactome: R-HSA-3214841;Reactome: R-HSA-5693565;Reactome: R-HSA-171306;Reactome: R-HSA-73772;Reactome: R-HSA-8936459;Reactome: R-HSA-1912408;Reactome: R-HSA-2299718;Reactome: R-HSA-110329;Reactome: R-HSA-9610379;Reactome: R-HSA-5334118;Reactome: R-HSA-427359;Reactome: R-HSA-2559586;Reactome: R-HSA-110330;Reactome: R-HSA-912446;Reactome: R-HSA-977225;Reactome: R-HSA-5578749;Reactome: R-HSA-201722;Reactome: R-HSA-1221632;Reactome: R-HSA-5617472;Reactome: R-HSA-73728;Reactome: R-HSA-5625886;Reactome: R-HSA-2559582;Reactome: R-HSA-9609690;Reactome: R-HSA-69473;Reactome: R-HSA-9018519;Reactome: R-HSA-5693571;Reactome: R-HSA-110328	"Cleavage of the damaged purine";"NoRC negatively regulates rRNA expression";"Oxidative Stress Induced Senescence";"Processing of DNA double-strand break ends";"RMTs methylate histone arginines";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"B-WICH complex positively regulates rRNA expression";"HATs acetylate histones";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Deposition of new CENPA-containing nucleosomes at the centromere";"HDMs demethylate histones";"Transcriptional regulation of granulopoiesis";"HDACs deacetylate histones";"PRC2 methylates histones and DNA";"SUMOylation of chromatin organization proteins";"PKMTs methylate histone lysines";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Packaging Of Telomere Ends";"RNA Polymerase I Promoter Escape";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Pre-NOTCH Transcription and Translation";"Condensation of Prophase Chromosomes";"Cleavage of the damaged pyrimidine";"HCMV Late Events";"DNA methylation";"SIRT1 negatively regulates rRNA expression";"DNA Damage/Telomere Stress Induced Senescence";"Recognition and association of DNA glycosylase with site containing an affected purine";"Meiotic recombination";"Amyloid fiber formation";"Transcriptional regulation by small RNAs";"Formation of the beta-catenin:TCF transactivating complex";"Meiotic synapsis";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"RNA Polymerase I Promoter Opening";"Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3";"Senescence-Associated Secretory Phenotype (SASP)";"HCMV Early Events";"G2/M DNA damage checkpoint";"Estrogen-dependent gene expression";"Nonhomologous End-Joining (NHEJ)";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine"
XP_046420156.1	1	Reactome: R-HSA-5662702	"Melanin biosynthesis"
XP_046411820.1	4	MetaCyc: PWY-7219;KEGG: 00730+2.7.4.3;Reactome: R-HSA-499943;KEGG: 00230+2.7.4.3	"Adenosine ribonucleotides de novo biosynthesis";"Thiamine metabolism";"Interconversion of nucleotide di- and triphosphates";"Purine metabolism"
XP_046413673.1	13	Reactome: R-HSA-2408557;Reactome: R-HSA-72706;Reactome: R-HSA-1799339;Reactome: R-HSA-9633012;Reactome: R-HSA-72689;Reactome: R-HSA-192823;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-975956;Reactome: R-HSA-156902;Reactome: R-HSA-72764;Reactome: R-HSA-975957;Reactome: R-HSA-6791226	"Selenocysteine synthesis";"GTP hydrolysis and joining of the 60S ribosomal subunit";"SRP-dependent cotranslational protein targeting to membrane";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Formation of a pool of free 40S subunits";"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Peptide chain elongation";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046427125.1	1	Reactome: R-HSA-162791	"Attachment of GPI anchor to uPAR"
XP_046410736.1	4	Reactome: R-HSA-5576893;Reactome: R-HSA-5576892;Reactome: R-HSA-419037;Reactome: R-HSA-112308	"Phase 2 - plateau phase";"Phase 0 - rapid depolarisation";"NCAM1 interactions";"Presynaptic depolarization and calcium channel opening"
XP_046429622.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_046412067.1	1	Reactome: R-HSA-977347	"Serine biosynthesis"
XP_046436658.1	7	Reactome: R-HSA-73980;Reactome: R-HSA-73780;Reactome: R-HSA-76071;Reactome: R-HSA-1834949;Reactome: R-HSA-749476;Reactome: R-HSA-76061;Reactome: R-HSA-76066	"RNA Polymerase III Transcription Termination";"RNA Polymerase III Chain Elongation";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Transcription Initiation From Type 2 Promoter"
XP_046419160.1	9	Reactome: R-HSA-114608;Reactome: R-HSA-6802955;Reactome: R-HSA-5674135;Reactome: R-HSA-6802952;Reactome: R-HSA-9649948;Reactome: R-HSA-6802948;Reactome: R-HSA-6802946;Reactome: R-HSA-6798695;Reactome: R-HSA-445355	"Platelet degranulation";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"MAP2K and MAPK activation";"Signaling by BRAF and RAF fusions";"Signaling downstream of RAS mutants";"Signaling by high-kinase activity BRAF mutants";"Signaling by moderate kinase activity BRAF mutants";"Neutrophil degranulation";"Smooth Muscle Contraction"
XP_046411099.1	2	Reactome: R-HSA-6784531;Reactome: R-HSA-6791226	"tRNA processing in the nucleus";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046432497.1	2	Reactome: R-HSA-189451;KEGG: 00860+4.99.1.1	"Heme biosynthesis";"Porphyrin and chlorophyll metabolism"
XP_046425122.1	8	KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;Reactome: R-HSA-437239;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1	"Thermogenesis";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Recycling pathway of L1";"Human cytomegalovirus infection";"Relaxin signaling pathway";"PI3K-Akt signaling pathway";"mTOR signaling pathway"
XP_046409656.1	4	Reactome: R-HSA-1483191;Reactome: R-HSA-422085;Reactome: R-HSA-112311;KEGG: 00564+3.1.1.7	"Synthesis of PC";"Synthesis, secretion, and deacylation of Ghrelin";"Neurotransmitter clearance";"Glycerophospholipid metabolism"
XP_046427190.1	11	KEGG: 04926+2.7.11.1;Reactome: R-HSA-450302;KEGG: 05163+2.7.11.1;Reactome: R-HSA-171007;Reactome: R-HSA-4420097;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;Reactome: R-HSA-2559580	"Relaxin signaling pathway";"activated TAK1 mediates p38 MAPK activation";"Human cytomegalovirus infection";"p38MAPK events";"VEGFA-VEGFR2 Pathway";"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Thermogenesis";"Oxidative Stress Induced Senescence"
XP_046430998.1	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
XP_046432894.1	13	Reactome: R-HSA-72706;Reactome: R-HSA-2408557;Reactome: R-HSA-1799339;Reactome: R-HSA-72689;Reactome: R-HSA-9633012;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-192823;Reactome: R-HSA-156902;Reactome: R-HSA-975956;Reactome: R-HSA-72764;Reactome: R-HSA-975957;Reactome: R-HSA-6791226	"GTP hydrolysis and joining of the 60S ribosomal subunit";"Selenocysteine synthesis";"SRP-dependent cotranslational protein targeting to membrane";"Formation of a pool of free 40S subunits";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Viral mRNA Translation";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046420768.1	5	Reactome: R-HSA-159231;Reactome: R-HSA-72163;Reactome: R-HSA-72187;Reactome: R-HSA-73856;Reactome: R-HSA-77595	"Transport of Mature mRNA Derived from an Intronless Transcript";"mRNA Splicing - Major Pathway";"mRNA 3'-end processing";"RNA Polymerase II Transcription Termination";"Processing of Intronless Pre-mRNAs"
XP_046433530.1	2	Reactome: R-HSA-446199;Reactome: R-HSA-4755609	"Synthesis of Dolichyl-phosphate";"Defective DHDDS causes retinitis pigmentosa 59"
XP_046421028.1	6	MetaCyc: PWY-7782;MetaCyc: PWY-5884;MetaCyc: PWY-6733;Reactome: R-HSA-9640463;MetaCyc: PWY-7656;KEGG: 00073+1.2.1.84	"Plasmalogen biosynthesis";"Wax esters biosynthesis I";"Sporopollenin precursors biosynthesis";"Wax biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Cutin, suberine and wax biosynthesis"
XP_046426212.1	3	Reactome: R-HSA-193648;Reactome: R-HSA-194840;Reactome: R-HSA-416482	"NRAGE signals death through JNK";"Rho GTPase cycle";"G alpha (12/13) signalling events"
XP_046431989.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_046428945.1	7	KEGG: 00240+3.5.2.3;KEGG: 00230+3.5.2.5;MetaCyc: PWY-5686;MetaCyc: PWY-5698;MetaCyc: PWY-7791;MetaCyc: PWY-5697;MetaCyc: PWY-7790	"Pyrimidine metabolism";"Purine metabolism";"UMP biosynthesis I";"Allantoin degradation to ureidoglycolate II (ammonia producing)";"UMP biosynthesis III";"Allantoin degradation to ureidoglycolate I (urea producing)";"UMP biosynthesis II"
XP_046421707.1	1	Reactome: R-HSA-8949664	"Processing of SMDT1"
XP_046419727.1	1	Reactome: R-HSA-203641	"NOSTRIN mediated eNOS trafficking"
XP_046419517.1	3	Reactome: R-HSA-8874081;Reactome: R-HSA-3000171;Reactome: R-HSA-3000157	"MET activates PTK2 signaling";"Non-integrin membrane-ECM interactions";"Laminin interactions"
XP_046435413.1	1	Reactome: R-HSA-8876725	"Protein methylation"
XP_046413080.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046430197.1	2	Reactome: R-HSA-3928665;Reactome: R-HSA-2682334	"EPH-ephrin mediated repulsion of cells";"EPH-Ephrin signaling"
XP_046409923.1	2	Reactome: R-HSA-6804758;Reactome: R-HSA-3214847	"Regulation of TP53 Activity through Acetylation";"HATs acetylate histones"
XP_046413115.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_046413775.1	1	Reactome: R-HSA-216083	"Integrin cell surface interactions"
XP_046425353.1	5	Reactome: R-HSA-189451;KEGG: 00260+2.3.1.37;MetaCyc: PWY-5189;MetaCyc: PWY-7536;KEGG: 00860+2.3.1.37	"Heme biosynthesis";"Glycine, serine and threonine metabolism";"Tetrapyrrole biosynthesis II (from glycine)";"2-amino-3-hydroxycyclopent-2-enone biosynthesis";"Porphyrin and chlorophyll metabolism"
XP_046415438.1	1	Reactome: R-HSA-373080	"Class B/2 (Secretin family receptors)"
XP_046415566.1	2	Reactome: R-HSA-4090294;Reactome: R-HSA-383280	"SUMOylation of intracellular receptors";"Nuclear Receptor transcription pathway"
XP_046421998.1	2	Reactome: R-HSA-1296052;Reactome: R-HSA-418457	"Ca2+ activated K+ channels";"cGMP effects"
XP_046422054.1	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
XP_046412741.1	1	Reactome: R-HSA-1799339	"SRP-dependent cotranslational protein targeting to membrane"
XP_046418160.1	6	Reactome: R-HSA-5626467;Reactome: R-HSA-8957275;Reactome: R-HSA-201722;Reactome: R-HSA-381426;Reactome: R-HSA-2173796;Reactome: R-HSA-3769402	"RHO GTPases activate IQGAPs";"Post-translational protein phosphorylation";"Formation of the beta-catenin:TCF transactivating complex";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"Deactivation of the beta-catenin transactivating complex"
XP_046422242.1	1	Reactome: R-HSA-606279	"Deposition of new CENPA-containing nucleosomes at the centromere"
XP_046433284.1	52	Reactome: R-HSA-5578749;Reactome: R-HSA-73762;Reactome: R-HSA-167287;Reactome: R-HSA-167158;Reactome: R-HSA-6781827;Reactome: R-HSA-203927;Reactome: R-HSA-6782210;Reactome: R-HSA-113418;Reactome: R-HSA-167162;Reactome: R-HSA-6807505;Reactome: R-HSA-6781823;Reactome: R-HSA-9018519;Reactome: R-HSA-8851708;Reactome: R-HSA-167161;Reactome: R-HSA-168325;Reactome: R-HSA-73776;Reactome: R-HSA-72086;Reactome: R-HSA-72163;Reactome: R-HSA-167243;Reactome: R-HSA-112382;Reactome: R-HSA-73780;Reactome: R-HSA-75955;Reactome: R-HSA-5617472;Reactome: R-HSA-76042;Reactome: R-HSA-72203;Reactome: R-HSA-167160;Reactome: R-HSA-5250924;Reactome: R-HSA-6782135;Reactome: R-HSA-73779;Reactome: R-HSA-167238;Reactome: R-HSA-73980;Reactome: R-HSA-72165;Reactome: R-HSA-167246;Reactome: R-HSA-76066;Reactome: R-HSA-75953;Reactome: R-HSA-427413;Reactome: R-HSA-6803529;Reactome: R-HSA-167152;Reactome: R-HSA-749476;Reactome: R-HSA-1834949;Reactome: R-HSA-167290;Reactome: R-HSA-73772;Reactome: R-HSA-6796648;Reactome: R-HSA-77075;Reactome: R-HSA-167200;Reactome: R-HSA-76061;Reactome: R-HSA-167242;Reactome: R-HSA-674695;Reactome: R-HSA-76071;Reactome: R-HSA-73863;Reactome: R-HSA-5601884;Reactome: R-HSA-167172	"Transcriptional regulation by small RNAs";"RNA Polymerase I Transcription Initiation";"HIV elongation arrest and recovery";"Formation of the HIV-1 Early Elongation Complex";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"MicroRNA (miRNA) biogenesis";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Formation of the Early Elongation Complex";"RNA Polymerase II HIV Promoter Escape";"RNA polymerase II transcribes snRNA genes";"Formation of TC-NER Pre-Incision Complex";"Estrogen-dependent gene expression";"Signaling by FGFR2 IIIa TM";"HIV Transcription Initiation";"Viral Messenger RNA Synthesis";"RNA Polymerase II Promoter Escape";"mRNA Capping";"mRNA Splicing - Major Pathway";"Tat-mediated HIV elongation arrest and recovery";"Formation of RNA Pol II elongation complex";"RNA Polymerase III Chain Elongation";"RNA Polymerase II Transcription Elongation";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Processing of Capped Intron-Containing Pre-mRNA";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"B-WICH complex positively regulates rRNA expression";"Dual incision in TC-NER";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Pausing and recovery of Tat-mediated HIV elongation";"RNA Polymerase III Transcription Termination";"mRNA Splicing - Minor Pathway";"Tat-mediated elongation of the HIV-1 transcript";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase II Transcription Initiation";"NoRC negatively regulates rRNA expression";"FGFR2 alternative splicing";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Polymerase III Abortive And Retractive Initiation";"Cytosolic sensors of pathogen-associated DNA";"Pausing and recovery of HIV elongation";"RNA Polymerase I Promoter Escape";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Pol II CTD phosphorylation and interaction with CE";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"Abortive elongation of HIV-1 transcript in the absence of Tat";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase I Transcription Termination";"PIWI-interacting RNA (piRNA) biogenesis";"Transcription of the HIV genome"
XP_046425962.1	2	Reactome: R-HSA-5673001;Reactome: R-HSA-8853659	"RAF/MAP kinase cascade";"RET signaling"
XP_046417918.1	13	Reactome: R-HSA-975957;Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-975956;Reactome: R-HSA-72764;Reactome: R-HSA-9633012;Reactome: R-HSA-72689;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-192823;Reactome: R-HSA-72706;Reactome: R-HSA-2408557;Reactome: R-HSA-1799339	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Formation of a pool of free 40S subunits";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Viral mRNA Translation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Selenocysteine synthesis";"SRP-dependent cotranslational protein targeting to membrane"
XP_046418013.1	4	Reactome: R-HSA-382556;Reactome: R-HSA-5358346;Reactome: R-HSA-5678895;Reactome: R-HSA-5362768	"ABC-family proteins mediated transport";"Hedgehog ligand biogenesis";"Defective CFTR causes cystic fibrosis";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD"
XP_046425883.1	1	Reactome: R-HSA-1971475	"A tetrasaccharide linker sequence is required for GAG synthesis"
XP_046411566.1	1	Reactome: R-HSA-212436	"Generic Transcription Pathway"
XP_046412816.1	1	Reactome: R-HSA-9033241	"Peroxisomal protein import"
XP_046432724.1	6	Reactome: R-HSA-975578;MetaCyc: PWY-7426;KEGG: 00510+2.4.1.143;Reactome: R-HSA-4793952;MetaCyc: PWY-7920;KEGG: 00513+2.4.1.143	"Reactions specific to the complex N-glycan synthesis pathway";"Complex N-linked glycan biosynthesis (vertebrates)";"N-Glycan biosynthesis";"Defective MGAT2 causes MGAT2-CDG (CDG-2a)";"Complex N-linked glycan biosynthesis (plants)";"Various types of N-glycan biosynthesis"
XP_046421178.1	1	Reactome: R-HSA-3108214	"SUMOylation of DNA damage response and repair proteins"
XP_046416128.1	1	Reactome: R-HSA-6802952	"Signaling by BRAF and RAF fusions"
XP_046427173.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046424493.1	10	Reactome: R-HSA-76042;Reactome: R-HSA-75953;Reactome: R-HSA-167172;Reactome: R-HSA-167162;Reactome: R-HSA-674695;Reactome: R-HSA-73776;Reactome: R-HSA-73779;Reactome: R-HSA-167161;Reactome: R-HSA-6804756;Reactome: R-HSA-3214847	"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II Transcription Initiation";"Transcription of the HIV genome";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"HIV Transcription Initiation";"Regulation of TP53 Activity through Phosphorylation";"HATs acetylate histones"
XP_046423293.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_046424987.1	11	Reactome: R-HSA-5610787;Reactome: R-HSA-163615;Reactome: R-HSA-170670;KEGG: 00230+4.6.1.1;Reactome: R-HSA-418594;Reactome: R-HSA-432040;Reactome: R-HSA-418555;Reactome: R-HSA-170660;Reactome: R-HSA-418597;Reactome: R-HSA-164378;Reactome: R-HSA-163359	"Hedgehog 'off' state";"PKA activation";"Adenylate cyclase inhibitory pathway";"Purine metabolism";"G alpha (i) signalling events";"Vasopressin regulates renal water homeostasis via Aquaporins";"G alpha (s) signalling events";"Adenylate cyclase activating pathway";"G alpha (z) signalling events";"PKA activation in glucagon signalling";"Glucagon signaling in metabolic regulation"
XP_046433270.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046435353.1	1	Reactome: R-HSA-611105	"Respiratory electron transport"
XP_046424589.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046418912.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_046424222.1	5	Reactome: R-HSA-6798695;MetaCyc: PWY-5381;KEGG: 00760+6.3.4.21;Reactome: R-HSA-1368108;Reactome: R-HSA-197264	"Neutrophil degranulation";"Pyridine nucleotide cycling (plants)";"Nicotinate and nicotinamide metabolism";"BMAL1:CLOCK,NPAS2 activates circadian gene expression";"Nicotinamide salvaging"
XP_046416599.1	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
XP_046429649.1	5	MetaCyc: PWY-7426;KEGG: 00510+2.4.1.68;KEGG: 00533+2.4.1.68;KEGG: 00513+2.4.1.68;Reactome: R-HSA-975578	"Complex N-linked glycan biosynthesis (vertebrates)";"N-Glycan biosynthesis";"Glycosaminoglycan biosynthesis - keratan sulfate";"Various types of N-glycan biosynthesis";"Reactions specific to the complex N-glycan synthesis pathway"
XP_046419096.1	4	KEGG: 00450+2.9.1.2;KEGG: 00970+2.9.1.2;MetaCyc: PWY-6281;Reactome: R-HSA-2408557	"Selenocompound metabolism";"Aminoacyl-tRNA biosynthesis";"L-selenocysteine biosynthesis II (archaea and eukaryotes)";"Selenocysteine synthesis"
XP_046433646.1	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
XP_046421581.1	4	Reactome: R-HSA-75955;Reactome: R-HSA-674695;Reactome: R-HSA-112382;Reactome: R-HSA-8866654	"RNA Polymerase II Transcription Elongation";"RNA Polymerase II Pre-transcription Events";"Formation of RNA Pol II elongation complex";"E3 ubiquitin ligases ubiquitinate target proteins"
XP_046413457.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_046430533.1	14	MetaCyc: PWY-7725;MetaCyc: PWY-7619;MetaCyc: PWY-7601;KEGG: 00062+2.3.1.199;MetaCyc: PWY-5080;MetaCyc: PWY-7036;MetaCyc: PWY-6598;MetaCyc: PWY-7602;MetaCyc: PWY-8041;MetaCyc: PWY-7035;MetaCyc: PWY-6433;MetaCyc: PWY-5972;Reactome: R-HSA-75876;MetaCyc: PWY-7724	"Arachidonate biosynthesis V (8-detaturase, mammals)";"Juniperonate biosynthesis";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Fatty acid elongation";"Very long chain fatty acid biosynthesis I";"Very long chain fatty acid biosynthesis II";"Sciadonate biosynthesis";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Ultra-long-chain fatty acid biosynthesis";"(9Z)-tricosene biosynthesis";"Hydroxylated fatty acid biosynthesis (plants)";"Stearate biosynthesis I (animals)";"Synthesis of very long-chain fatty acyl-CoAs";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)"
XP_046427450.1	11	MetaCyc: PWY-882;Reactome: R-HSA-4043916;KEGG: 00520+5.3.1.8;MetaCyc: PWY-3881;KEGG: 00051+5.3.1.8;MetaCyc: PWY-7586;MetaCyc: PWY-3861;Reactome: R-HSA-446205;MetaCyc: PWY-7456;MetaCyc: PWY-5659;MetaCyc: PWY-6992	"L-ascorbate biosynthesis I (L-galactose pathway)";"Defective MPI causes MPI-CDG (CDG-1b)";"Amino sugar and nucleotide sugar metabolism";"Mannitol biosynthesis";"Fructose and mannose metabolism";"Beta-1,4-d-mannosyl-n-acetyl-d-glucosamine degradation";"Mannitol degradation II";"Synthesis of GDP-mannose";"Beta-(1,4)-mannan degradation";"GDP-mannose biosynthesis";"1,5-anhydrofructose degradation"
XP_046427100.1	1	Reactome: R-HSA-8964038	"LDL clearance"
XP_046417575.1	2	Reactome: R-HSA-2151201;Reactome: R-HSA-163282	"Transcriptional activation of mitochondrial biogenesis";"Mitochondrial transcription initiation"
XP_046416822.1	3	Reactome: R-HSA-6811434;Reactome: R-HSA-2132295;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"MHC class II antigen presentation";"Kinesins"
XP_046433145.1	1	Reactome: R-HSA-1632852	"Macroautophagy"
XP_046436429.1	4	KEGG: 00520+3.2.1.14;MetaCyc: PWY-7822;MetaCyc: PWY-6855;MetaCyc: PWY-6902	"Amino sugar and nucleotide sugar metabolism";"Chitin degradation III (Serratia)";"Chitin degradation I (archaea)";"Chitin degradation II (Vibrio)"
XP_046433754.1	5	MetaCyc: PWY-7210;KEGG: 00240+3.6.1.6;KEGG: 00230+3.6.1.6;Reactome: R-HSA-6798695;MetaCyc: PWY-7185	"Pyrimidine deoxyribonucleotides biosynthesis from CTP";"Pyrimidine metabolism";"Purine metabolism";"Neutrophil degranulation";"UTP and CTP dephosphorylation I"
XP_046432867.1	1	Reactome: R-HSA-6809371	"Formation of the cornified envelope"
XP_046424180.1	2	Reactome: R-HSA-3299685;MetaCyc: PWY-6854	"Detoxification of Reactive Oxygen Species";"Ethylene biosynthesis III (microbes)"
XP_046433720.1	2	KEGG: 00970+6.1.1.1;Reactome: R-HSA-379716	"Aminoacyl-tRNA biosynthesis";"Cytosolic tRNA aminoacylation"
XP_046435587.1	6	Reactome: R-HSA-5609978;KEGG: 00052+2.7.7.12;MetaCyc: PWY-6527;KEGG: 00520+2.7.7.12;Reactome: R-HSA-70370;MetaCyc: PWY-6317	"Defective GALT can cause Galactosemia";"Galactose metabolism";"Stachyose degradation";"Amino sugar and nucleotide sugar metabolism";"Galactose catabolism";"D-galactose degradation I (Leloir pathway)"
XP_046410058.1	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
XP_046425848.1	1	Reactome: R-HSA-71064	"Lysine catabolism"
XP_046420161.1	1	Reactome: R-HSA-5666185	"RHO GTPases Activate Rhotekin and Rhophilins"
XP_046432102.1	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
XP_046431806.1	2	Reactome: R-HSA-6804115;Reactome: R-HSA-429947	"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Deadenylation of mRNA"
XP_046417237.1	7	Reactome: R-HSA-2500257;Reactome: R-HSA-5663220;Reactome: R-HSA-2467813;Reactome: R-HSA-68877;Reactome: R-HSA-4615885;Reactome: R-HSA-141444;Reactome: R-HSA-9648025	"Resolution of Sister Chromatid Cohesion";"RHO GTPases Activate Formins";"Separation of Sister Chromatids";"Mitotic Prometaphase";"SUMOylation of DNA replication proteins";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"EML4 and NUDC in mitotic spindle formation"
XP_046418981.1	2	KEGG: 04660+2.7.10.2;Reactome: R-HSA-1433557	"T cell receptor signaling pathway";"Signaling by SCF-KIT"
XP_046422940.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_046432054.1	1	KEGG: 00531+3.2.1.35	"Glycosaminoglycan degradation"
XP_046419268.1	1	Reactome: R-HSA-6784531	"tRNA processing in the nucleus"
XP_046431472.1	1	Reactome: R-HSA-163560	"Triglyceride catabolism"
XP_046414173.1	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
XP_046426020.1	2	MetaCyc: PWY-4261;KEGG: 00561+2.7.1.30	"Glycerol degradation I";"Glycerolipid metabolism"
XP_046430187.1	2	Reactome: R-HSA-2032785;Reactome: R-HSA-8951671	"YAP1- and WWTR1 (TAZ)-stimulated gene expression";"RUNX3 regulates YAP1-mediated transcription"
XP_046417160.1	56	Reactome: R-HSA-9020702;Reactome: R-HSA-8854050;Reactome: R-HSA-174113;Reactome: R-HSA-5687128;Reactome: R-HSA-5689603;Reactome: R-HSA-68827;Reactome: R-HSA-5607764;Reactome: R-HSA-187577;Reactome: R-HSA-180534;Reactome: R-HSA-1234176;Reactome: R-HSA-8948751;Reactome: R-HSA-69481;Reactome: R-HSA-8852276;Reactome: R-HSA-5610783;Reactome: R-HSA-1236974;Reactome: R-HSA-5610780;Reactome: R-HSA-450408;Reactome: R-HSA-5632684;Reactome: R-HSA-4641258;Reactome: R-HSA-211733;Reactome: R-HSA-5668541;Reactome: R-HSA-9010553;Reactome: R-HSA-350562;Reactome: R-HSA-8941858;Reactome: R-HSA-69017;Reactome: R-HSA-69601;Reactome: R-HSA-5358346;Reactome: R-HSA-5362768;Reactome: R-HSA-9604323;Reactome: R-HSA-5676590;Reactome: R-HSA-68949;Reactome: R-HSA-1169091;Reactome: R-HSA-382556;Reactome: R-HSA-2871837;Reactome: R-HSA-174178;Reactome: R-HSA-195253;Reactome: R-HSA-174084;Reactome: R-HSA-8951664;Reactome: R-HSA-5689880;Reactome: R-HSA-349425;Reactome: R-HSA-1236978;Reactome: R-HSA-4608870;Reactome: R-HSA-4641257;Reactome: R-HSA-202424;Reactome: R-HSA-75815;Reactome: R-HSA-5678895;Reactome: R-HSA-180585;Reactome: R-HSA-5610785;Reactome: R-HSA-8939236;Reactome: R-HSA-5607761;Reactome: R-HSA-983168;Reactome: R-HSA-5658442;Reactome: R-HSA-174154;Reactome: R-HSA-174184;Reactome: R-HSA-8939902;Reactome: R-HSA-2467813	"Interleukin-1 signaling";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"SCF-beta-TrCP mediated degradation of Emi1";"MAPK6/MAPK4 signaling";"UCH proteinases";"CDT1 association with the CDC6:ORC:origin complex";"CLEC7A (Dectin-1) signaling";"SCF(Skp2)-mediated degradation of p27/p21";"Vpu mediated degradation of CD4";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of PTEN stability and activity";"G2/M Checkpoints";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Degradation of GLI2 by the proteasome";"ER-Phagosome pathway";"Degradation of GLI1 by the proteasome";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Hedgehog 'on' state";"Degradation of DVL";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"TNFR2 non-canonical NF-kB pathway";"Regulation of expression of SLITs and ROBOs";"Regulation of ornithine decarboxylase (ODC)";"Regulation of RUNX3 expression and activity";"CDK-mediated phosphorylation and removal of Cdc6";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Hedgehog ligand biogenesis";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Negative regulation of NOTCH4 signaling";"NIK-->noncanonical NF-kB signaling";"Orc1 removal from chromatin";"Activation of NF-kappaB in B cells";"ABC-family proteins mediated transport";"FCERI mediated NF-kB activation";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Degradation of beta-catenin by the destruction complex";"Autodegradation of Cdh1 by Cdh1:APC/C";"Neddylation";"Ub-specific processing proteases";"Autodegradation of the E3 ubiquitin ligase COP1";"Cross-presentation of soluble exogenous antigens (endosomes)";"Asymmetric localization of PCP proteins";"Degradation of AXIN";"Downstream TCR signaling";"Ubiquitin-dependent degradation of Cyclin D";"Defective CFTR causes cystic fibrosis";"Vif-mediated degradation of APOBEC3G";"GLI3 is processed to GLI3R by the proteasome";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Dectin-1 mediated noncanonical NF-kB signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Regulation of RAS by GAPs";"APC/C:Cdc20 mediated degradation of Securin";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Regulation of RUNX2 expression and activity";"Separation of Sister Chromatids"
XP_046432580.1	1	Reactome: R-HSA-425986	"Sodium/Proton exchangers"
XP_046412015.1	1	Reactome: R-HSA-420499	"Class C/3 (Metabotropic glutamate/pheromone receptors)"
XP_046411179.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_046412485.1	4	Reactome: R-HSA-6781823;Reactome: R-HSA-8951664;Reactome: R-HSA-8856825;Reactome: R-HSA-5696394	"Formation of TC-NER Pre-Incision Complex";"Neddylation";"Cargo recognition for clathrin-mediated endocytosis";"DNA Damage Recognition in GG-NER"
XP_046421541.1	1	Reactome: R-HSA-1799339	"SRP-dependent cotranslational protein targeting to membrane"
XP_046426464.1	3	MetaCyc: PWY-4261;Reactome: R-HSA-75109;KEGG: 00561+2.7.1.30	"Glycerol degradation I";"Triglyceride biosynthesis";"Glycerolipid metabolism"
XP_046413607.1	1	MetaCyc: PWY-7533	"Gliotoxin biosynthesis"
XP_046428423.1	7	KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1	"Human cytomegalovirus infection";"Thermogenesis";"Relaxin signaling pathway";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"PI3K-Akt signaling pathway";"mTOR signaling pathway"
XP_046429013.1	2	Reactome: R-HSA-446203;Reactome: R-HSA-1799339	"Asparagine N-linked glycosylation";"SRP-dependent cotranslational protein targeting to membrane"
XP_046423262.1	17	Reactome: R-HSA-163765;KEGG: 00620+6.4.1.2;MetaCyc: PWY-5744;KEGG: 00254+6.4.1.2;MetaCyc: PWY-6722;MetaCyc: PWY-6679;Reactome: R-HSA-2426168;MetaCyc: PWY-5743;KEGG: 00720+6.4.1.2;MetaCyc: PWY-4381;MetaCyc: PWY-5789;KEGG: 00061+6.4.1.2;Reactome: R-HSA-3371599;Reactome: R-HSA-200425;KEGG: 00640+6.4.1.2;MetaCyc: PWY-5966-1;Reactome: R-HSA-196780	"ChREBP activates metabolic gene expression";"Pyruvate metabolism";"Glyoxylate assimilation";"Aflatoxin biosynthesis";"Candicidin biosynthesis";"Jadomycin biosynthesis";"Activation of gene expression by SREBF (SREBP)";"3-hydroxypropanoate cycle";"Carbon fixation pathways in prokaryotes";"Fatty acid biosynthesis initiation (bacteria and plants)";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Fatty acid biosynthesis";"Defective HLCS causes multiple carboxylase deficiency";"Carnitine metabolism";"Propanoate metabolism";"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)";"Biotin transport and metabolism"
XP_046416545.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046411420.1	5	MetaCyc: PWY-7269;KEGG: 00760+2.7.1.23;Reactome: R-HSA-196807;MetaCyc: PWY-7268;MetaCyc: PWY-5083	"NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)";"Nicotinate and nicotinamide metabolism";"Nicotinate metabolism";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"NAD/NADH phosphorylation and dephosphorylation"
XP_046436577.1	1	Reactome: R-HSA-9037629	"Lewis blood group biosynthesis"
XP_046429486.1	5	MetaCyc: PWY-6891;KEGG: 00900+2.2.1.7;MetaCyc: PWY-7560;KEGG: 00730+2.2.1.7;MetaCyc: PWY-6892	"Thiazole biosynthesis II (aerobic bacteria)";"Terpenoid backbone biosynthesis";"Methylerythritol phosphate pathway II";"Thiamine metabolism";"Thiazole biosynthesis I (facultative anaerobic bacteria)"
XP_046420556.1	1	Reactome: R-HSA-1632852	"Macroautophagy"
XP_046431974.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046434678.1	1	Reactome: R-HSA-6784531	"tRNA processing in the nucleus"
XP_046422165.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046425421.1	2	Reactome: R-HSA-162588;Reactome: R-HSA-917729	"Budding and maturation of HIV virion";"Endosomal Sorting Complex Required For Transport (ESCRT)"
XP_046432803.1	1	KEGG: 00480+3.4.11.1	"Glutathione metabolism"
XP_046435105.1	4	Reactome: R-HSA-446210;MetaCyc: PWY-6906;MetaCyc: PWY-6517;KEGG: 00520+2.7.1.59	"Synthesis of UDP-N-acetyl-glucosamine";"Chitin derivatives degradation";"N-acetylglucosamine degradation II";"Amino sugar and nucleotide sugar metabolism"
XP_046421175.1	1	Reactome: R-HSA-3108214	"SUMOylation of DNA damage response and repair proteins"
XP_046425586.1	7	KEGG: 00020+1.2.4.1;Reactome: R-HSA-389661;Reactome: R-HSA-5362517;Reactome: R-HSA-204174;Reactome: R-HSA-70268;KEGG: 00010+1.2.4.1;KEGG: 00620+1.2.4.1	"Citrate cycle (TCA cycle)";"Glyoxylate metabolism and glycine degradation";"Signaling by Retinoic Acid";"Regulation of pyruvate dehydrogenase (PDH) complex";"Pyruvate metabolism";"Glycolysis / Gluconeogenesis";"Pyruvate metabolism"
XP_046434880.1	2	Reactome: R-HSA-418555;Reactome: R-HSA-444821	"G alpha (s) signalling events";"Relaxin receptors"
XP_046412199.1	2	Reactome: R-HSA-168276;Reactome: R-HSA-1169408	"NS1 Mediated Effects on Host Pathways";"ISG15 antiviral mechanism"
XP_046432796.1	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
XP_046414451.1	4	Reactome: R-HSA-167160;MetaCyc: PWY-7375;Reactome: R-HSA-77075;Reactome: R-HSA-72086	"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Mrna capping I";"RNA Pol II CTD phosphorylation and interaction with CE";"mRNA Capping"
XP_046417594.1	2	Reactome: R-HSA-416476;Reactome: R-HSA-375281	"G alpha (q) signalling events";"Hormone ligand-binding receptors"
XP_046417756.1	11	Reactome: R-HSA-174437;Reactome: R-HSA-5693568;Reactome: R-HSA-5693579;Reactome: R-HSA-5693607;Reactome: R-HSA-5685942;Reactome: R-HSA-69166;Reactome: R-HSA-69473;Reactome: R-HSA-6804756;Reactome: R-HSA-5685938;Reactome: R-HSA-5693554;Reactome: R-HSA-5693616	"Removal of the Flap Intermediate from the C-strand";"Resolution of D-loop Structures through Holliday Junction Intermediates";"Homologous DNA Pairing and Strand Exchange";"Processing of DNA double-strand break ends";"HDR through Homologous Recombination (HRR)";"Removal of the Flap Intermediate";"G2/M DNA damage checkpoint";"Regulation of TP53 Activity through Phosphorylation";"HDR through Single Strand Annealing (SSA)";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Presynaptic phase of homologous DNA pairing and strand exchange"
XP_046433715.1	2	Reactome: R-HSA-8949215;Reactome: R-HSA-8949664	"Mitochondrial calcium ion transport";"Processing of SMDT1"
XP_046434167.1	9	Reactome: R-HSA-9630221;Reactome: R-HSA-110357;Reactome: R-HSA-110330;Reactome: R-HSA-110331;Reactome: R-HSA-110329;Reactome: R-HSA-110328;Reactome: R-HSA-9608287;Reactome: R-HSA-9608290;Reactome: R-HSA-9630222	"Defective NTHL1 substrate processing";"Displacement of DNA glycosylase by APEX1";"Recognition and association of DNA glycosylase with site containing an affected purine";"Cleavage of the damaged purine";"Cleavage of the damaged pyrimidine";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"Defective MUTYH substrate binding";"Defective MUTYH substrate processing";"Defective NTHL1 substrate binding"
XP_046431180.1	2	Reactome: R-HSA-9627069;Reactome: R-HSA-111458	"Regulation of the apoptosome activity";"Formation of apoptosome"
XP_046421476.1	1	Reactome: R-HSA-435368	"Zinc efflux and compartmentalization by the SLC30 family"
XP_046430413.1	27	Reactome: R-HSA-159227;Reactome: R-HSA-168333;Reactome: R-HSA-168271;Reactome: R-HSA-4615885;Reactome: R-HSA-159230;Reactome: R-HSA-180746;Reactome: R-HSA-5578749;Reactome: R-HSA-191859;Reactome: R-HSA-168276;Reactome: R-HSA-5619107;Reactome: R-HSA-3301854;Reactome: R-HSA-4551638;Reactome: R-HSA-6784531;Reactome: R-HSA-4085377;Reactome: R-HSA-165054;Reactome: R-HSA-3371453;Reactome: R-HSA-180910;Reactome: R-HSA-3232142;Reactome: R-HSA-170822;Reactome: R-HSA-9609690;Reactome: R-HSA-168325;Reactome: R-HSA-3108214;Reactome: R-HSA-1169408;Reactome: R-HSA-159231;Reactome: R-HSA-159236;Reactome: R-HSA-4570464;Reactome: R-HSA-9610379	"Transport of the SLBP independent Mature mRNA";"NEP/NS2 Interacts with the Cellular Export Machinery";"Transport of Ribonucleoproteins into the Host Nucleus";"SUMOylation of DNA replication proteins";"Transport of the SLBP Dependant Mature mRNA";"Nuclear import of Rev protein";"Transcriptional regulation by small RNAs";"snRNP Assembly";"NS1 Mediated Effects on Host Pathways";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Nuclear Pore Complex (NPC) Disassembly";"SUMOylation of chromatin organization proteins";"tRNA processing in the nucleus";"SUMOylation of SUMOylation proteins";"Rev-mediated nuclear export of HIV RNA";"Regulation of HSF1-mediated heat shock response";"Vpr-mediated nuclear import of PICs";"SUMOylation of ubiquitinylation proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"HCMV Early Events";"Viral Messenger RNA Synthesis";"SUMOylation of DNA damage response and repair proteins";"ISG15 antiviral mechanism";"Transport of Mature mRNA Derived from an Intronless Transcript";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"SUMOylation of RNA binding proteins";"HCMV Late Events"
XP_046414486.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_046417797.1	5	Reactome: R-HSA-3247509;Reactome: R-HSA-3214858;Reactome: R-HSA-1266695;Reactome: R-HSA-201722;Reactome: R-HSA-8939243	"Chromatin modifying enzymes";"RMTs methylate histone arginines";"Interleukin-7 signaling";"Formation of the beta-catenin:TCF transactivating complex";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"
XP_046422210.1	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
XP_046427012.1	1	KEGG: 00230+4.6.1.2	"Purine metabolism"
XP_046412114.1	17	Reactome: R-HSA-6804114;Reactome: R-HSA-139915;Reactome: R-HSA-2559585;Reactome: R-HSA-111448;Reactome: R-HSA-1912408;Reactome: R-HSA-2173796;Reactome: R-HSA-1538133;Reactome: R-HSA-69231;Reactome: R-HSA-8953750;Reactome: R-HSA-9616222;Reactome: R-HSA-1362300;Reactome: R-HSA-113501;Reactome: R-HSA-2559580;Reactome: R-HSA-69656;Reactome: R-HSA-69202;Reactome: R-HSA-69205;Reactome: R-HSA-1362277	"TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest";"Activation of PUMA and translocation to mitochondria";"Oncogene Induced Senescence";"Activation of NOXA and translocation to mitochondria";"Pre-NOTCH Transcription and Translation";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"G0 and Early G1";"Cyclin D associated events in G1";"Transcriptional Regulation by E2F6";"Transcriptional regulation of granulopoiesis";"Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1";"Inhibition of replication initiation of damaged DNA by RB1/E2F1";"Oxidative Stress Induced Senescence";"Cyclin A:Cdk2-associated events at S phase entry";"Cyclin E associated events during G1/S transition";"G1/S-Specific Transcription";"Transcription of E2F targets under negative control by DREAM complex"
XP_046424269.1	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046413212.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_046429650.1	5	MetaCyc: PWY-7426;KEGG: 00510+2.4.1.68;KEGG: 00533+2.4.1.68;KEGG: 00513+2.4.1.68;Reactome: R-HSA-975578	"Complex N-linked glycan biosynthesis (vertebrates)";"N-Glycan biosynthesis";"Glycosaminoglycan biosynthesis - keratan sulfate";"Various types of N-glycan biosynthesis";"Reactions specific to the complex N-glycan synthesis pathway"
XP_046427221.1	8	KEGG: 00983+3.5.4.5;KEGG: 00240+3.5.4.5;MetaCyc: PWY-7181;Reactome: R-HSA-6798695;MetaCyc: PWY-7193;MetaCyc: PWY-6556;Reactome: R-HSA-73614;MetaCyc: PWY-7199	"Drug metabolism - other enzymes";"Pyrimidine metabolism";"Pyrimidine deoxyribonucleosides degradation";"Neutrophil degranulation";"Pyrimidine ribonucleosides salvage I";"Pyrimidine ribonucleosides salvage II";"Pyrimidine salvage";"Pyrimidine deoxyribonucleosides salvage"
XP_046430826.1	1	Reactome: R-HSA-203927	"MicroRNA (miRNA) biogenesis"
XP_046413598.1	5	Reactome: R-HSA-5625740;Reactome: R-HSA-75035;Reactome: R-HSA-1445148;Reactome: R-HSA-111447;Reactome: R-HSA-5628897	"RHO GTPases activate PKNs";"Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Activation of BAD and translocation to mitochondria";"TP53 Regulates Metabolic Genes"
XP_046420186.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_046415623.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_046415584.1	1	Reactome: R-HSA-433137	"Sodium-coupled sulphate, di- and tri-carboxylate transporters"
XP_046418342.1	13	Reactome: R-HSA-975957;Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-975956;Reactome: R-HSA-72764;Reactome: R-HSA-9633012;Reactome: R-HSA-72689;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-192823;Reactome: R-HSA-72706;Reactome: R-HSA-2408557;Reactome: R-HSA-1799339	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Formation of a pool of free 40S subunits";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Viral mRNA Translation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Selenocysteine synthesis";"SRP-dependent cotranslational protein targeting to membrane"
XP_046430056.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046434792.1	1	Reactome: R-HSA-163560	"Triglyceride catabolism"
XP_046423990.1	3	Reactome: R-HSA-204005;Reactome: R-HSA-162658;Reactome: R-HSA-6807878	"COPII-mediated vesicle transport";"Golgi Cisternae Pericentriolar Stack Reorganization";"COPI-mediated anterograde transport"
XP_046431060.1	13	KEGG: 00520+3.2.1.52;Reactome: R-HSA-2024101;MetaCyc: PWY-7822;KEGG: 00513+3.2.1.52;MetaCyc: PWY-6902;KEGG: 00531+3.2.1.52;Reactome: R-HSA-2160916;KEGG: 00604+3.2.1.52;KEGG: 00603+3.2.1.52;KEGG: 00511+3.2.1.52;Reactome: R-HSA-1660662;Reactome: R-HSA-2022857;MetaCyc: PWY-7883	"Amino sugar and nucleotide sugar metabolism";"CS/DS degradation";"Chitin degradation III (Serratia)";"Various types of N-glycan biosynthesis";"Chitin degradation II (Vibrio)";"Glycosaminoglycan degradation";"Hyaluronan uptake and degradation";"Glycosphingolipid biosynthesis - ganglio series";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Other glycan degradation";"Glycosphingolipid metabolism";"Keratan sulfate degradation";"Anhydromuropeptides recycling II"
XP_046412367.1	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276	"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination"
XP_046421619.1	3	Reactome: R-HSA-1855167;MetaCyc: PWY-6369;KEGG: 04070+2.7.4.24+2.7.4.21	"Synthesis of pyrophosphates in the cytosol";"Inositol diphosphates biosynthesis";"Phosphatidylinositol signaling system"
XP_046424930.1	1	Reactome: R-HSA-432720	"Lysosome Vesicle Biogenesis"
XP_046417899.1	6	Reactome: R-HSA-72689;Reactome: R-HSA-156827;Reactome: R-HSA-72702;Reactome: R-HSA-72695;Reactome: R-HSA-72706;Reactome: R-HSA-72649	"Formation of a pool of free 40S subunits";"L13a-mediated translational silencing of Ceruloplasmin expression";"Ribosomal scanning and start codon recognition";"Formation of the ternary complex, and subsequently, the 43S complex";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Translation initiation complex formation"
XP_046424179.1	2	MetaCyc: PWY-6854;Reactome: R-HSA-3299685	"Ethylene biosynthesis III (microbes)";"Detoxification of Reactive Oxygen Species"
XP_046428441.1	7	KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1	"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Relaxin signaling pathway";"Thermogenesis";"Human cytomegalovirus infection"
XP_046413003.1	1	Reactome: R-HSA-6811440	"Retrograde transport at the Trans-Golgi-Network"
XP_046418154.1	1	Reactome: R-HSA-1445148	"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
XP_046426375.1	6	Reactome: R-HSA-176974;Reactome: R-HSA-68867;Reactome: R-HSA-176187;Reactome: R-HSA-68962;Reactome: R-HSA-68949;Reactome: R-HSA-69052	"Unwinding of DNA";"Assembly of the pre-replicative complex";"Activation of ATR in response to replication stress";"Activation of the pre-replicative complex";"Orc1 removal from chromatin";"Switching of origins to a post-replicative state"
XP_046409486.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046421888.1	2	Reactome: R-HSA-1660661;KEGG: 04070+2.7.11.13	"Sphingolipid de novo biosynthesis";"Phosphatidylinositol signaling system"
XP_046412981.1	1	Reactome: R-HSA-112126	"ALKBH3 mediated reversal of alkylation damage"
XP_046418198.1	3	Reactome: R-HSA-6794361;Reactome: R-HSA-264870;Reactome: R-HSA-6798695	"Neurexins and neuroligins";"Caspase-mediated cleavage of cytoskeletal proteins";"Neutrophil degranulation"
XP_046428682.1	1	Reactome: R-HSA-432722	"Golgi Associated Vesicle Biogenesis"
XP_046410988.1	1	Reactome: R-HSA-6811440	"Retrograde transport at the Trans-Golgi-Network"
XP_046435744.1	6	Reactome: R-HSA-141444;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813;Reactome: R-HSA-68877;Reactome: R-HSA-2500257;Reactome: R-HSA-5663220	"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids";"Mitotic Prometaphase";"Resolution of Sister Chromatid Cohesion";"RHO GTPases Activate Formins"
XP_046416522.1	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
XP_046426747.1	3	Reactome: R-HSA-8951664;Reactome: R-HSA-349425;MetaCyc: PWY-7511	"Neddylation";"Autodegradation of the E3 ubiquitin ligase COP1";"Protein ubiquitination"
XP_046416781.1	1	Reactome: R-HSA-2151201	"Transcriptional activation of mitochondrial biogenesis"
XP_046419515.1	3	Reactome: R-HSA-3000157;Reactome: R-HSA-8874081;Reactome: R-HSA-3000171	"Laminin interactions";"MET activates PTK2 signaling";"Non-integrin membrane-ECM interactions"
XP_046411195.1	2	Reactome: R-HSA-8876198;Reactome: R-HSA-204005	"RAB GEFs exchange GTP for GDP on RABs";"COPII-mediated vesicle transport"
XP_046420802.1	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
XP_046418997.1	1	Reactome: R-HSA-5620922	"BBSome-mediated cargo-targeting to cilium"
XP_046431391.1	2	Reactome: R-HSA-9033500;Reactome: R-HSA-9033241	"TYSND1 cleaves peroxisomal proteins";"Peroxisomal protein import"
XP_046430663.1	1	Reactome: R-HSA-6794361	"Neurexins and neuroligins"
XP_046409879.1	2	Reactome: R-HSA-110320;Reactome: R-HSA-983168	"Translesion Synthesis by POLH";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046432721.1	6	Reactome: R-HSA-975578;KEGG: 00510+2.4.1.143;MetaCyc: PWY-7426;Reactome: R-HSA-4793952;KEGG: 00513+2.4.1.143;MetaCyc: PWY-7920	"Reactions specific to the complex N-glycan synthesis pathway";"N-Glycan biosynthesis";"Complex N-linked glycan biosynthesis (vertebrates)";"Defective MGAT2 causes MGAT2-CDG (CDG-2a)";"Various types of N-glycan biosynthesis";"Complex N-linked glycan biosynthesis (plants)"
XP_046410012.1	1	Reactome: R-HSA-2022928	"HS-GAG biosynthesis"
XP_046421719.1	2	Reactome: R-HSA-2408522;Reactome: R-HSA-379716	"Selenoamino acid metabolism";"Cytosolic tRNA aminoacylation"
XP_046433756.1	6	Reactome: R-HSA-72702;Reactome: R-HSA-72695;Reactome: R-HSA-72706;Reactome: R-HSA-72649;Reactome: R-HSA-72689;Reactome: R-HSA-156827	"Ribosomal scanning and start codon recognition";"Formation of the ternary complex, and subsequently, the 43S complex";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Translation initiation complex formation";"Formation of a pool of free 40S subunits";"L13a-mediated translational silencing of Ceruloplasmin expression"
XP_046430423.1	1	Reactome: R-HSA-5689901	"Metalloprotease DUBs"
XP_046410570.1	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
XP_046431119.1	2	Reactome: R-HSA-445355;Reactome: R-HSA-390522	"Smooth Muscle Contraction";"Striated Muscle Contraction"
XP_046427915.1	6	MetaCyc: PWY-7817;KEGG: 00561+2.7.1.107;MetaCyc: PWY-7039;KEGG: 04070+2.7.1.107;KEGG: 00564+2.7.1.107;Reactome: R-HSA-114508	"Type I lipoteichoic acid biosynthesis (S. aureus)";"Glycerolipid metabolism";"Phosphatidate metabolism, as a signaling molecule";"Phosphatidylinositol signaling system";"Glycerophospholipid metabolism";"Effects of PIP2 hydrolysis"
XP_046413041.1	3	Reactome: R-HSA-8874081;Reactome: R-HSA-3000171;Reactome: R-HSA-3000157	"MET activates PTK2 signaling";"Non-integrin membrane-ECM interactions";"Laminin interactions"
XP_046424776.1	4	Reactome: R-HSA-381771;Reactome: R-HSA-400511;Reactome: R-HSA-1799339;Reactome: R-HSA-422085	"Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)";"Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)";"SRP-dependent cotranslational protein targeting to membrane";"Synthesis, secretion, and deacylation of Ghrelin"
XP_046417180.1	57	Reactome: R-HSA-5610785;Reactome: R-HSA-5678895;Reactome: R-HSA-180585;Reactome: R-HSA-8939236;Reactome: R-HSA-349425;Reactome: R-HSA-174084;Reactome: R-HSA-5689880;Reactome: R-HSA-8951664;Reactome: R-HSA-202424;Reactome: R-HSA-75815;Reactome: R-HSA-4608870;Reactome: R-HSA-4641257;Reactome: R-HSA-1236978;Reactome: R-HSA-8939902;Reactome: R-HSA-174184;Reactome: R-HSA-174154;Reactome: R-HSA-2467813;Reactome: R-HSA-5658442;Reactome: R-HSA-983168;Reactome: R-HSA-5607761;Reactome: R-HSA-6798695;Reactome: R-HSA-180534;Reactome: R-HSA-187577;Reactome: R-HSA-5607764;Reactome: R-HSA-68827;Reactome: R-HSA-5689603;Reactome: R-HSA-5610783;Reactome: R-HSA-8852276;Reactome: R-HSA-69481;Reactome: R-HSA-8948751;Reactome: R-HSA-1234176;Reactome: R-HSA-9020702;Reactome: R-HSA-8854050;Reactome: R-HSA-5687128;Reactome: R-HSA-174113;Reactome: R-HSA-5676590;Reactome: R-HSA-5362768;Reactome: R-HSA-9604323;Reactome: R-HSA-5358346;Reactome: R-HSA-69601;Reactome: R-HSA-69017;Reactome: R-HSA-195253;Reactome: R-HSA-174178;Reactome: R-HSA-2871837;Reactome: R-HSA-68949;Reactome: R-HSA-1169091;Reactome: R-HSA-382556;Reactome: R-HSA-4641258;Reactome: R-HSA-211733;Reactome: R-HSA-5632684;Reactome: R-HSA-5610780;Reactome: R-HSA-450408;Reactome: R-HSA-1236974;Reactome: R-HSA-9010553;Reactome: R-HSA-8941858;Reactome: R-HSA-350562;Reactome: R-HSA-5668541	"GLI3 is processed to GLI3R by the proteasome";"Defective CFTR causes cystic fibrosis";"Vif-mediated degradation of APOBEC3G";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Autodegradation of the E3 ubiquitin ligase COP1";"Autodegradation of Cdh1 by Cdh1:APC/C";"Ub-specific processing proteases";"Neddylation";"Downstream TCR signaling";"Ubiquitin-dependent degradation of Cyclin D";"Asymmetric localization of PCP proteins";"Degradation of AXIN";"Cross-presentation of soluble exogenous antigens (endosomes)";"Regulation of RUNX2 expression and activity";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"APC/C:Cdc20 mediated degradation of Securin";"Separation of Sister Chromatids";"Regulation of RAS by GAPs";"Antigen processing: Ubiquitination & Proteasome degradation";"Dectin-1 mediated noncanonical NF-kB signaling";"Neutrophil degranulation";"Vpu mediated degradation of CD4";"SCF(Skp2)-mediated degradation of p27/p21";"CLEC7A (Dectin-1) signaling";"CDT1 association with the CDC6:ORC:origin complex";"UCH proteinases";"Degradation of GLI2 by the proteasome";"The role of GTSE1 in G2/M progression after G2 checkpoint";"G2/M Checkpoints";"Regulation of PTEN stability and activity";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Interleukin-1 signaling";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"MAPK6/MAPK4 signaling";"SCF-beta-TrCP mediated degradation of Emi1";"NIK-->noncanonical NF-kB signaling";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Negative regulation of NOTCH4 signaling";"Hedgehog ligand biogenesis";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"CDK-mediated phosphorylation and removal of Cdc6";"Degradation of beta-catenin by the destruction complex";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"FCERI mediated NF-kB activation";"Orc1 removal from chromatin";"Activation of NF-kappaB in B cells";"ABC-family proteins mediated transport";"Degradation of DVL";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Hedgehog 'on' state";"Degradation of GLI1 by the proteasome";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"ER-Phagosome pathway";"Regulation of expression of SLITs and ROBOs";"Regulation of RUNX3 expression and activity";"Regulation of ornithine decarboxylase (ODC)";"TNFR2 non-canonical NF-kB pathway"
XP_046434956.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046417481.1	1	Reactome: R-HSA-211945	"Phase I - Functionalization of compounds"
XP_046412838.1	2	Reactome: R-HSA-5620924;Reactome: R-HSA-5610787	"Intraflagellar transport";"Hedgehog 'off' state"
XP_046435384.1	2	Reactome: R-HSA-8856828;Reactome: R-HSA-8856825	"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis"
XP_046412658.1	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
XP_046410926.1	14	MetaCyc: PWY-5972;Reactome: R-HSA-75876;MetaCyc: PWY-7724;MetaCyc: PWY-6433;MetaCyc: PWY-7035;MetaCyc: PWY-6598;MetaCyc: PWY-7036;MetaCyc: PWY-7602;MetaCyc: PWY-8041;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7601;MetaCyc: PWY-5080;MetaCyc: PWY-7725;MetaCyc: PWY-7619	"Stearate biosynthesis I (animals)";"Synthesis of very long-chain fatty acyl-CoAs";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Hydroxylated fatty acid biosynthesis (plants)";"(9Z)-tricosene biosynthesis";"Sciadonate biosynthesis";"Very long chain fatty acid biosynthesis II";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Ultra-long-chain fatty acid biosynthesis";"Fatty acid elongation";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis I";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Juniperonate biosynthesis"
XP_046422102.1	1	Reactome: R-HSA-6783310	"Fanconi Anemia Pathway"
XP_046415334.1	9	Reactome: R-HSA-3642279;Reactome: R-HSA-2173788;Reactome: R-HSA-3645790;Reactome: R-HSA-3656532;Reactome: R-HSA-5689603;Reactome: R-HSA-2173791;Reactome: R-HSA-2173789;Reactome: R-HSA-3304356;Reactome: R-HSA-3656535	"TGFBR2 MSI Frameshift Mutants in Cancer";"Downregulation of TGF-beta receptor signaling";"TGFBR2 Kinase Domain Mutants in Cancer";"TGFBR1 KD Mutants in Cancer";"UCH proteinases";"TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)";"TGF-beta receptor signaling activates SMADs";"SMAD2/3 Phosphorylation Motif Mutants in Cancer";"TGFBR1 LBD Mutants in Cancer"
XP_046427483.1	2	Reactome: R-HSA-5576892;Reactome: R-HSA-5576893	"Phase 0 - rapid depolarisation";"Phase 2 - plateau phase"
XP_046436607.1	1	Reactome: R-HSA-6804756	"Regulation of TP53 Activity through Phosphorylation"
XP_046433625.1	2	Reactome: R-HSA-5689880;Reactome: R-HSA-3214847	"Ub-specific processing proteases";"HATs acetylate histones"
XP_046429789.1	1	Reactome: R-HSA-1660499	"Synthesis of PIPs at the plasma membrane"
XP_046425054.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_046410277.1	2	Reactome: R-HSA-429947;Reactome: R-HSA-6804115	"Deadenylation of mRNA";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"
XP_046415430.1	6	Reactome: R-HSA-181430;Reactome: R-HSA-264642;Reactome: R-HSA-388844;Reactome: R-HSA-212676;Reactome: R-HSA-210500;Reactome: R-HSA-181429	"Norepinephrine Neurotransmitter Release Cycle";"Acetylcholine Neurotransmitter Release Cycle";"Receptor-type tyrosine-protein phosphatases";"Dopamine Neurotransmitter Release Cycle";"Glutamate Neurotransmitter Release Cycle";"Serotonin Neurotransmitter Release Cycle"
XP_046411389.1	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
XP_046417989.1	5	KEGG: 00030+4.1.2.4;MetaCyc: PWY-8060;Reactome: R-HSA-6798695;Reactome: R-HSA-71336;MetaCyc: PWY-7180	"Pentose phosphate pathway";"2-deoxy-D-ribose degradation I";"Neutrophil degranulation";"Pentose phosphate pathway";"2-deoxy-alpha-D-ribose 1-phosphate degradation"
XP_046421015.1	6	MetaCyc: PWY-5884;MetaCyc: PWY-7782;MetaCyc: PWY-6733;Reactome: R-HSA-9640463;MetaCyc: PWY-7656;KEGG: 00073+1.2.1.84	"Wax esters biosynthesis I";"Plasmalogen biosynthesis";"Sporopollenin precursors biosynthesis";"Wax biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Cutin, suberine and wax biosynthesis"
XP_046418018.1	1	Reactome: R-HSA-5223345	"Miscellaneous transport and binding events"
XP_046432022.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_046414547.1	1	Reactome: R-HSA-5617833	"Cilium Assembly"
XP_046432924.1	1	Reactome: R-HSA-110362	"POLB-Dependent Long Patch Base Excision Repair"
XP_046434949.1	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
XP_046410515.1	6	KEGG: 00564+2.7.1.107;Reactome: R-HSA-114508;KEGG: 04070+2.7.1.107;KEGG: 00561+2.7.1.107;MetaCyc: PWY-7039;MetaCyc: PWY-7817	"Glycerophospholipid metabolism";"Effects of PIP2 hydrolysis";"Phosphatidylinositol signaling system";"Glycerolipid metabolism";"Phosphatidate metabolism, as a signaling molecule";"Type I lipoteichoic acid biosynthesis (S. aureus)"
XP_046421354.1	1	Reactome: R-HSA-9037629	"Lewis blood group biosynthesis"
XP_046423551.1	12	Reactome: R-HSA-1912408;Reactome: R-HSA-210744;Reactome: R-HSA-3214847;Reactome: R-HSA-2894862;Reactome: R-HSA-9013695;Reactome: R-HSA-73762;Reactome: R-HSA-5250924;Reactome: R-HSA-8941856;Reactome: R-HSA-350054;Reactome: R-HSA-2122947;Reactome: R-HSA-9013508;Reactome: R-HSA-2644606	"Pre-NOTCH Transcription and Translation";"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"HATs acetylate histones";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"NOTCH4 Intracellular Domain Regulates Transcription";"RNA Polymerase I Transcription Initiation";"B-WICH complex positively regulates rRNA expression";"RUNX3 regulates NOTCH signaling";"Notch-HLH transcription pathway";"NOTCH1 Intracellular Domain Regulates Transcription";"NOTCH3 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 PEST Domain Mutants"
XP_046418934.1	1	Reactome: R-HSA-5693571	"Nonhomologous End-Joining (NHEJ)"
XP_046420546.1	2	Reactome: R-HSA-983231;Reactome: R-HSA-383280	"Factors involved in megakaryocyte development and platelet production";"Nuclear Receptor transcription pathway"
XP_046433542.1	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_046415362.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046431965.1	8	KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;Reactome: R-HSA-418889;KEGG: 04714+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1	"Human cytomegalovirus infection";"Relaxin signaling pathway";"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Caspase activation via Dependence Receptors in the absence of ligand";"Thermogenesis";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection"
XP_046410223.1	6	Reactome: R-HSA-72163;Reactome: R-HSA-191859;Reactome: R-HSA-73856;Reactome: R-HSA-77588;Reactome: R-HSA-72165;Reactome: R-HSA-111367	"mRNA Splicing - Major Pathway";"snRNP Assembly";"RNA Polymerase II Transcription Termination";"SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs";"mRNA Splicing - Minor Pathway";"SLBP independent Processing of Histone Pre-mRNAs"
XP_046415883.1	24	Reactome: R-HSA-3371497;Reactome: R-HSA-5663220;Reactome: R-HSA-437239;Reactome: R-HSA-190840;Reactome: R-HSA-68877;Reactome: R-HSA-8852276;Reactome: R-HSA-6811436;Reactome: R-HSA-190861;Reactome: R-HSA-9646399;Reactome: R-HSA-8955332;Reactome: R-HSA-9609736;Reactome: R-HSA-2132295;Reactome: R-HSA-5617833;Reactome: R-HSA-6807878;Reactome: R-HSA-5626467;Reactome: R-HSA-1445148;Reactome: R-HSA-2500257;Reactome: R-HSA-983189;Reactome: R-HSA-9619483;Reactome: R-HSA-9609690;Reactome: R-HSA-2467813;Reactome: R-HSA-9648025;Reactome: R-HSA-380320;Reactome: R-HSA-6811434	"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"RHO GTPases Activate Formins";"Recycling pathway of L1";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Mitotic Prometaphase";"The role of GTSE1 in G2/M progression after G2 checkpoint";"COPI-independent Golgi-to-ER retrograde traffic";"Gap junction assembly";"Aggrephagy";"Carboxyterminal post-translational modifications of tubulin";"Assembly and cell surface presentation of NMDA receptors";"MHC class II antigen presentation";"Cilium Assembly";"COPI-mediated anterograde transport";"RHO GTPases activate IQGAPs";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Resolution of Sister Chromatid Cohesion";"Kinesins";"Activation of AMPK downstream of NMDARs";"HCMV Early Events";"Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation";"Recruitment of NuMA to mitotic centrosomes";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_046425430.1	2	Reactome: R-HSA-162588;Reactome: R-HSA-917729	"Budding and maturation of HIV virion";"Endosomal Sorting Complex Required For Transport (ESCRT)"
XP_046429527.1	2	Reactome: R-HSA-8876198;Reactome: R-HSA-5357905	"RAB GEFs exchange GTP for GDP on RABs";"Regulation of TNFR1 signaling"
XP_046420159.1	1	Reactome: R-HSA-5666185	"RHO GTPases Activate Rhotekin and Rhophilins"
XP_046423102.1	1	Reactome: R-HSA-3299685	"Detoxification of Reactive Oxygen Species"
XP_046422127.1	5	Reactome: R-HSA-964975;MetaCyc: PWY-7282;Reactome: R-HSA-6798695;MetaCyc: PWY-7204;KEGG: 00750+2.7.1.35	"Vitamins B6 activation to pyridoxal phosphate";"4-amino-2-methyl-5-phosphomethylpyrimidine biosynthesis";"Neutrophil degranulation";"Pyridoxal 5'-phosphate salvage II (plants)";"Vitamin B6 metabolism"
XP_046417798.1	5	Reactome: R-HSA-3247509;Reactome: R-HSA-3214858;Reactome: R-HSA-1266695;Reactome: R-HSA-201722;Reactome: R-HSA-8939243	"Chromatin modifying enzymes";"RMTs methylate histone arginines";"Interleukin-7 signaling";"Formation of the beta-catenin:TCF transactivating complex";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"
XP_046432108.1	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
XP_046419270.1	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
XP_046431655.1	1	Reactome: R-HSA-435368	"Zinc efflux and compartmentalization by the SLC30 family"
XP_046411291.1	2	Reactome: R-HSA-167826;Reactome: R-HSA-167827	"The fatty acid cycling model";"The proton buffering model"
XP_046431262.1	3	Reactome: R-HSA-5423646;Reactome: R-HSA-2142691;MetaCyc: PWY-7533	"Aflatoxin activation and detoxification";"Synthesis of Leukotrienes (LT) and Eoxins (EX)";"Gliotoxin biosynthesis"
XP_046426000.1	2	Reactome: R-HSA-8866654;MetaCyc: PWY-7511	"E3 ubiquitin ligases ubiquitinate target proteins";"Protein ubiquitination"
XP_046418917.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_046422143.1	6	MetaCyc: PWY-622;MetaCyc: PWY-7900;MetaCyc: PWY-5067;KEGG: 00500+2.4.1.18;KEGG: 00500+3.2.1.1;Reactome: R-HSA-189085	"Starch biosynthesis";"Glycogen biosynthesis III (from alpha-maltose 1-phosphate)";"Glycogen biosynthesis II (from UDP-D-Glucose)";"Starch and sucrose metabolism";"Starch and sucrose metabolism";"Digestion of dietary carbohydrate"
XP_046414487.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_046424840.1	1	KEGG: 00450+1.8.1.9	"Selenocompound metabolism"
XP_046428505.1	3	Reactome: R-HSA-212436;Reactome: R-HSA-381340;Reactome: R-HSA-1989781	"Generic Transcription Pathway";"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression"
XP_046418354.1	5	Reactome: R-HSA-3270619;Reactome: R-HSA-3249367;Reactome: R-HSA-1834941;Reactome: R-HSA-6798695;Reactome: R-HSA-3134975	"IRF3-mediated induction of type I IFN";"STAT6-mediated induction of chemokines";"STING mediated induction of host immune responses";"Neutrophil degranulation";"Regulation of innate immune responses to cytosolic DNA"
XP_046416839.1	1	Reactome: R-HSA-373080	"Class B/2 (Secretin family receptors)"
XP_046422860.1	1	Reactome: R-HSA-426048	"Arachidonate production from DAG"
XP_046414749.1	1	Reactome: R-HSA-425986	"Sodium/Proton exchangers"
XP_046432731.1	7	Reactome: R-HSA-380259;Reactome: R-HSA-8854518;Reactome: R-HSA-380270;Reactome: R-HSA-2565942;Reactome: R-HSA-380320;Reactome: R-HSA-380284;Reactome: R-HSA-5620912	"Loss of Nlp from mitotic centrosomes";"AURKA Activation by TPX2";"Recruitment of mitotic centrosome proteins and complexes";"Regulation of PLK1 Activity at G2/M Transition";"Recruitment of NuMA to mitotic centrosomes";"Loss of proteins required for interphase microtubule organization from the centrosome";"Anchoring of the basal body to the plasma membrane"
XP_046430581.1	1	Reactome: R-HSA-426117	"Cation-coupled Chloride cotransporters"
XP_046415327.1	2	Reactome: R-HSA-72764;Reactome: R-HSA-156581	"Eukaryotic Translation Termination";"Methylation"
XP_046430534.1	14	Reactome: R-HSA-75876;MetaCyc: PWY-5972;MetaCyc: PWY-7724;MetaCyc: PWY-6433;MetaCyc: PWY-7036;MetaCyc: PWY-6598;MetaCyc: PWY-7602;MetaCyc: PWY-8041;MetaCyc: PWY-7035;MetaCyc: PWY-7725;MetaCyc: PWY-7619;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7601;MetaCyc: PWY-5080	"Synthesis of very long-chain fatty acyl-CoAs";"Stearate biosynthesis I (animals)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Hydroxylated fatty acid biosynthesis (plants)";"Very long chain fatty acid biosynthesis II";"Sciadonate biosynthesis";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Ultra-long-chain fatty acid biosynthesis";"(9Z)-tricosene biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Juniperonate biosynthesis";"Fatty acid elongation";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis I"
XP_046419586.1	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
XP_046426243.1	5	Reactome: R-HSA-4085001;Reactome: R-HSA-2132295;Reactome: R-HSA-4341670;Reactome: R-HSA-6798695;Reactome: R-HSA-1660662	"Sialic acid metabolism";"MHC class II antigen presentation";"Defective NEU1 causes sialidosis";"Neutrophil degranulation";"Glycosphingolipid metabolism"
XP_046431416.1	3	Reactome: R-HSA-392154;Reactome: R-HSA-445355;KEGG: 00230+4.6.1.2	"Nitric oxide stimulates guanylate cyclase";"Smooth Muscle Contraction";"Purine metabolism"
XP_046434694.1	3	Reactome: R-HSA-74217;KEGG: 00230+3.5.4.6;MetaCyc: PWY-6596	"Purine salvage";"Purine metabolism";"Adenosine nucleotides degradation I"
XP_046428429.1	7	KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1	"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Relaxin signaling pathway";"Thermogenesis";"Human cytomegalovirus infection";"mTOR signaling pathway";"PI3K-Akt signaling pathway"
XP_046427171.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046409777.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_046412361.1	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
XP_046429293.1	1	Reactome: R-HSA-400253	"Circadian Clock"
XP_046416147.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_046413589.1	10	KEGG: 00030+2.7.1.11;KEGG: 00052+2.7.1.11;KEGG: 00051+2.7.1.11;Reactome: R-HSA-70171;KEGG: 00010+2.7.1.11;MetaCyc: PWY-1861;MetaCyc: PWY-5484;MetaCyc: PWY-1042;MetaCyc: PWY-7385;KEGG: 00680+2.7.1.11	"Pentose phosphate pathway";"Galactose metabolism";"Fructose and mannose metabolism";"Glycolysis";"Glycolysis / Gluconeogenesis";"Formaldehyde assimilation II (assimilatory RuMP Cycle)";"Glycolysis II (from fructose 6-phosphate)";"Glycolysis IV (plant cytosol)";"1,3-propanediol biosynthesis (engineered)";"Methane metabolism"
XP_046415718.1	2	Reactome: R-HSA-418555;Reactome: R-HSA-444821	"G alpha (s) signalling events";"Relaxin receptors"
XP_046413725.1	3	MetaCyc: PWY-6807;KEGG: 00511+3.2.1.51;Reactome: R-HSA-6798695	"Xyloglucan degradation II (exoglucanase)";"Other glycan degradation";"Neutrophil degranulation"
XP_046427205.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046428284.1	2	Reactome: R-HSA-4641265;Reactome: R-HSA-5339700	"Repression of WNT target genes";"TCF7L2 mutants don't bind CTBP"
XP_046411237.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046429628.1	1	KEGG: 00970+6.1.1.16	"Aminoacyl-tRNA biosynthesis"
XP_046428297.1	1	Reactome: R-HSA-209968	"Thyroxine biosynthesis"
XP_046411468.1	2	MetaCyc: PWY-7221;KEGG: 00230+2.7.4.8	"Guanosine ribonucleotides de novo biosynthesis";"Purine metabolism"
XP_046423666.1	1	Reactome: R-HSA-196843	"Vitamin B2 (riboflavin) metabolism"
XP_046422017.1	1	Reactome: R-HSA-2559584	"Formation of Senescence-Associated Heterochromatin Foci (SAHF)"
XP_046421380.1	2	Reactome: R-HSA-6783310;MetaCyc: PWY-7511	"Fanconi Anemia Pathway";"Protein ubiquitination"
XP_046418462.1	2	Reactome: R-HSA-5576892;Reactome: R-HSA-5576893	"Phase 0 - rapid depolarisation";"Phase 2 - plateau phase"
XP_046435735.1	1	Reactome: R-HSA-1221632	"Meiotic synapsis"
XP_046409937.1	14	MetaCyc: PWY-8055;MetaCyc: PWY-8051;MetaCyc: PWY-6453;MetaCyc: PWY-8052;KEGG: 00565+3.1.3.4;Reactome: R-HSA-4419969;Reactome: R-HSA-75109;MetaCyc: PWY-7782;Reactome: R-HSA-1483213;KEGG: 00561+3.1.3.4;MetaCyc: PWY-8053;KEGG: 00600+3.1.3.4;KEGG: 00564+3.1.3.4;Reactome: R-HSA-1483191	"Palmitoyl ethanolamide biosynthesis";"Anandamide biosynthesis I";"Stigma estolide biosynthesis";"2-arachidonoylglycerol biosynthesis";"Ether lipid metabolism";"Depolymerisation of the Nuclear Lamina";"Triglyceride biosynthesis";"Plasmalogen biosynthesis";"Synthesis of PE";"Glycerolipid metabolism";"Anandamide biosynthesis II";"Sphingolipid metabolism";"Glycerophospholipid metabolism";"Synthesis of PC"
XP_046415352.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046423455.1	19	Reactome: R-HSA-8950505;Reactome: R-HSA-5663220;Reactome: R-HSA-983231;Reactome: R-HSA-5625970;Reactome: R-HSA-5687128;Reactome: R-HSA-8964616;Reactome: R-HSA-5627123;Reactome: R-HSA-418885;Reactome: R-HSA-2029482;Reactome: R-HSA-182971;Reactome: R-HSA-3928662;Reactome: R-HSA-194840;Reactome: R-HSA-389359;Reactome: R-HSA-428543;Reactome: R-HSA-525793;Reactome: R-HSA-5626467;Reactome: R-HSA-114604;Reactome: R-HSA-5663213;Reactome: R-HSA-4420097	"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation";"RHO GTPases Activate Formins";"Factors involved in megakaryocyte development and platelet production";"RHO GTPases activate KTN1";"MAPK6/MAPK4 signaling";"G beta:gamma signalling through CDC42";"RHO GTPases activate PAKs";"DCC mediated attractive signaling";"Regulation of actin dynamics for phagocytic cup formation";"EGFR downregulation";"EPHB-mediated forward signaling";"Rho GTPase cycle";"CD28 dependent Vav1 pathway";"Inactivation of CDC42 and RAC1";"Myogenesis";"RHO GTPases activate IQGAPs";"GPVI-mediated activation cascade";"RHO GTPases Activate WASPs and WAVEs";"VEGFA-VEGFR2 Pathway"
XP_046433853.1	8	Reactome: R-HSA-2559580;Reactome: R-HSA-5617472;Reactome: R-HSA-212300;Reactome: R-HSA-4551638;Reactome: R-HSA-3214841;Reactome: R-HSA-8943724;Reactome: R-HSA-9609690;Reactome: R-HSA-8953750	"Oxidative Stress Induced Senescence";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"PRC2 methylates histones and DNA";"SUMOylation of chromatin organization proteins";"PKMTs methylate histone lysines";"Regulation of PTEN gene transcription";"HCMV Early Events";"Transcriptional Regulation by E2F6"
XP_046420910.1	2	Reactome: R-HSA-3214841;Reactome: R-HSA-8936459	"PKMTs methylate histone lysines";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"
XP_046430323.1	7	Reactome: R-HSA-1834949;Reactome: R-HSA-749476;Reactome: R-HSA-76071;Reactome: R-HSA-73780;Reactome: R-HSA-73980;Reactome: R-HSA-76066;Reactome: R-HSA-76061	"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Chain Elongation";"RNA Polymerase III Transcription Termination";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Transcription Initiation From Type 1 Promoter"
XP_046433659.1	6	Reactome: R-HSA-194840;Reactome: R-HSA-1855183;KEGG: 04070+3.1.3.36;KEGG: 00562+3.1.3.36;MetaCyc: PWY-6368;Reactome: R-HSA-1855204	"Rho GTPase cycle";"Synthesis of IP2, IP, and Ins in the cytosol";"Phosphatidylinositol signaling system";"Inositol phosphate metabolism";"3-phosphoinositide degradation";"Synthesis of IP3 and IP4 in the cytosol"
XP_046413487.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-5628897	"Respiratory electron transport";"TP53 Regulates Metabolic Genes"
XP_046424968.1	4	Reactome: R-HSA-9615710;Reactome: R-HSA-9646399;Reactome: R-HSA-3899300;Reactome: R-HSA-9613829	"Late endosomal microautophagy";"Aggrephagy";"SUMOylation of transcription cofactors";"Chaperone Mediated Autophagy"
XP_046420075.1	7	KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1	"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Relaxin signaling pathway";"Thermogenesis";"Human cytomegalovirus infection";"mTOR signaling pathway";"PI3K-Akt signaling pathway"
XP_046410600.1	1	Reactome: R-HSA-6799198	"Complex I biogenesis"
XP_046413881.1	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
XP_046413005.1	1	Reactome: R-HSA-379726	"Mitochondrial tRNA aminoacylation"
XP_046432740.1	7	Reactome: R-HSA-380259;Reactome: R-HSA-8854518;Reactome: R-HSA-2565942;Reactome: R-HSA-380270;Reactome: R-HSA-380320;Reactome: R-HSA-380284;Reactome: R-HSA-5620912	"Loss of Nlp from mitotic centrosomes";"AURKA Activation by TPX2";"Regulation of PLK1 Activity at G2/M Transition";"Recruitment of mitotic centrosome proteins and complexes";"Recruitment of NuMA to mitotic centrosomes";"Loss of proteins required for interphase microtubule organization from the centrosome";"Anchoring of the basal body to the plasma membrane"
XP_046423241.1	10	Reactome: R-HSA-5693568;Reactome: R-HSA-5693579;Reactome: R-HSA-5685942;Reactome: R-HSA-5693607;Reactome: R-HSA-912446;Reactome: R-HSA-6804756;Reactome: R-HSA-69473;Reactome: R-HSA-5685938;Reactome: R-HSA-5693554;Reactome: R-HSA-5693616	"Resolution of D-loop Structures through Holliday Junction Intermediates";"Homologous DNA Pairing and Strand Exchange";"HDR through Homologous Recombination (HRR)";"Processing of DNA double-strand break ends";"Meiotic recombination";"Regulation of TP53 Activity through Phosphorylation";"G2/M DNA damage checkpoint";"HDR through Single Strand Annealing (SSA)";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Presynaptic phase of homologous DNA pairing and strand exchange"
XP_046427992.1	3	Reactome: R-HSA-416482;Reactome: R-HSA-194840;Reactome: R-HSA-193648	"G alpha (12/13) signalling events";"Rho GTPase cycle";"NRAGE signals death through JNK"
XP_046432139.1	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
XP_046423087.1	1	Reactome: R-HSA-432047	"Passive transport by Aquaporins"
XP_046424572.1	1	Reactome: R-HSA-8849175	"Threonine catabolism"
XP_046435080.1	7	KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1	"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Human cytomegalovirus infection";"Thermogenesis";"Relaxin signaling pathway";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection"
XP_046425438.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046414624.1	4	Reactome: R-HSA-2644606;Reactome: R-HSA-2122947;Reactome: R-HSA-2894862;Reactome: R-HSA-350054	"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH1 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Notch-HLH transcription pathway"
XP_046412356.1	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
XP_046419582.1	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
XP_046423693.1	1	KEGG: 00970+6.1.1.7	"Aminoacyl-tRNA biosynthesis"
XP_046418392.1	1	Reactome: R-HSA-204005	"COPII-mediated vesicle transport"
XP_046419632.1	2	Reactome: R-HSA-983168;Reactome: R-HSA-8951664	"Antigen processing: Ubiquitination & Proteasome degradation";"Neddylation"
XP_046424145.1	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276	"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination"
XP_046432455.1	5	Reactome: R-HSA-6807004;Reactome: R-HSA-8875360;Reactome: R-HSA-8856828;Reactome: R-HSA-8856825;Reactome: R-HSA-182971	"Negative regulation of MET activity";"InlB-mediated entry of Listeria monocytogenes into host cell";"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis";"EGFR downregulation"
XP_046414227.1	5	Reactome: R-HSA-983168;Reactome: R-HSA-977225;Reactome: R-HSA-9646399;Reactome: R-HSA-5689877;Reactome: R-HSA-5205685	"Antigen processing: Ubiquitination & Proteasome degradation";"Amyloid fiber formation";"Aggrephagy";"Josephin domain DUBs";"Pink/Parkin Mediated Mitophagy"
XP_046428584.1	3	Reactome: R-HSA-76061;Reactome: R-HSA-76066;Reactome: R-HSA-749476	"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Abortive And Retractive Initiation"
XP_046430515.1	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
XP_046428147.1	1	Reactome: R-HSA-8949613	"Cristae formation"
XP_046428996.1	1	Reactome: R-HSA-3299685	"Detoxification of Reactive Oxygen Species"
XP_046410921.1	14	Reactome: R-HSA-75876;MetaCyc: PWY-5972;MetaCyc: PWY-7724;MetaCyc: PWY-6433;MetaCyc: PWY-7035;MetaCyc: PWY-7602;MetaCyc: PWY-6598;MetaCyc: PWY-7036;MetaCyc: PWY-8041;MetaCyc: PWY-7601;KEGG: 00062+2.3.1.199;MetaCyc: PWY-5080;MetaCyc: PWY-7725;MetaCyc: PWY-7619	"Synthesis of very long-chain fatty acyl-CoAs";"Stearate biosynthesis I (animals)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Hydroxylated fatty acid biosynthesis (plants)";"(9Z)-tricosene biosynthesis";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Sciadonate biosynthesis";"Very long chain fatty acid biosynthesis II";"Ultra-long-chain fatty acid biosynthesis";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Fatty acid elongation";"Very long chain fatty acid biosynthesis I";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Juniperonate biosynthesis"
XP_046432811.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_046424937.1	1	Reactome: R-HSA-432720	"Lysosome Vesicle Biogenesis"
XP_046417182.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046431260.1	3	MetaCyc: PWY-7533;Reactome: R-HSA-2142691;Reactome: R-HSA-5423646	"Gliotoxin biosynthesis";"Synthesis of Leukotrienes (LT) and Eoxins (EX)";"Aflatoxin activation and detoxification"
XP_046413492.1	11	Reactome: R-HSA-418594;Reactome: R-HSA-432040;Reactome: R-HSA-163615;Reactome: R-HSA-5610787;KEGG: 00230+4.6.1.1;Reactome: R-HSA-170670;Reactome: R-HSA-163359;Reactome: R-HSA-164378;Reactome: R-HSA-418555;Reactome: R-HSA-418597;Reactome: R-HSA-170660	"G alpha (i) signalling events";"Vasopressin regulates renal water homeostasis via Aquaporins";"PKA activation";"Hedgehog 'off' state";"Purine metabolism";"Adenylate cyclase inhibitory pathway";"Glucagon signaling in metabolic regulation";"PKA activation in glucagon signalling";"G alpha (s) signalling events";"G alpha (z) signalling events";"Adenylate cyclase activating pathway"
XP_046422732.1	4	Reactome: R-HSA-5660862;Reactome: R-HSA-210991;Reactome: R-HSA-352230;Reactome: R-HSA-71240	"Defective SLC7A7 causes lysinuric protein intolerance (LPI)";"Basigin interactions";"Amino acid transport across the plasma membrane";"Tryptophan catabolism"
XP_046433265.1	8	Reactome: R-HSA-69091;Reactome: R-HSA-113501;Reactome: R-HSA-68952;Reactome: R-HSA-174430;Reactome: R-HSA-174411;Reactome: R-HSA-68962;Reactome: R-HSA-69183;Reactome: R-HSA-69166	"Polymerase switching";"Inhibition of replication initiation of damaged DNA by RB1/E2F1";"DNA replication initiation";"Telomere C-strand synthesis initiation";"Polymerase switching on the C-strand of the telomere";"Activation of the pre-replicative complex";"Processive synthesis on the lagging strand";"Removal of the Flap Intermediate"
XP_046426634.1	4	Reactome: R-HSA-5419276;Reactome: R-HSA-1268020;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840	"Mitochondrial translation termination";"Mitochondrial protein import";"Mitochondrial translation initiation";"Mitochondrial translation elongation"
XP_046426910.1	1	Reactome: R-HSA-3238698	"WNT ligand biogenesis and trafficking"
XP_046422864.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
XP_046423886.1	3	Reactome: R-HSA-6811434;Reactome: R-HSA-983189;Reactome: R-HSA-2132295	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins";"MHC class II antigen presentation"
XP_046414745.1	1	Reactome: R-HSA-425986	"Sodium/Proton exchangers"
XP_046429233.1	1	Reactome: R-HSA-389661	"Glyoxylate metabolism and glycine degradation"
XP_046422745.1	4	MetaCyc: PWY-7887;Reactome: R-HSA-947581;MetaCyc: PWY-6823;KEGG: 00790+2.8.1.12	"Protein SAMPylation and SAMP-mediated thiolation";"Molybdenum cofactor biosynthesis";"Molybdenum cofactor biosynthesis";"Folate biosynthesis"
XP_046412221.1	1	KEGG: 00970+6.1.1.9	"Aminoacyl-tRNA biosynthesis"
XP_046431059.1	13	MetaCyc: PWY-7883;Reactome: R-HSA-2022857;Reactome: R-HSA-1660662;KEGG: 00511+3.2.1.52;KEGG: 00603+3.2.1.52;KEGG: 00604+3.2.1.52;Reactome: R-HSA-2160916;KEGG: 00531+3.2.1.52;MetaCyc: PWY-6902;KEGG: 00513+3.2.1.52;MetaCyc: PWY-7822;Reactome: R-HSA-2024101;KEGG: 00520+3.2.1.52	"Anhydromuropeptides recycling II";"Keratan sulfate degradation";"Glycosphingolipid metabolism";"Other glycan degradation";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Glycosphingolipid biosynthesis - ganglio series";"Hyaluronan uptake and degradation";"Glycosaminoglycan degradation";"Chitin degradation II (Vibrio)";"Various types of N-glycan biosynthesis";"Chitin degradation III (Serratia)";"CS/DS degradation";"Amino sugar and nucleotide sugar metabolism"
XP_046423944.1	14	Reactome: R-HSA-75876;MetaCyc: PWY-5972;MetaCyc: PWY-7724;MetaCyc: PWY-6433;MetaCyc: PWY-6598;MetaCyc: PWY-7602;MetaCyc: PWY-7036;MetaCyc: PWY-8041;MetaCyc: PWY-7035;MetaCyc: PWY-7725;MetaCyc: PWY-7619;MetaCyc: PWY-7601;KEGG: 00062+2.3.1.199;MetaCyc: PWY-5080	"Synthesis of very long-chain fatty acyl-CoAs";"Stearate biosynthesis I (animals)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Hydroxylated fatty acid biosynthesis (plants)";"Sciadonate biosynthesis";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis II";"Ultra-long-chain fatty acid biosynthesis";"(9Z)-tricosene biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Juniperonate biosynthesis";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Fatty acid elongation";"Very long chain fatty acid biosynthesis I"
XP_046417570.1	1	MetaCyc: PWY-7799	"Arg/N-end rule pathway (eukaryotic)"
XP_046435577.1	1	Reactome: R-HSA-947581	"Molybdenum cofactor biosynthesis"
XP_046433713.1	2	Reactome: R-HSA-8949664;Reactome: R-HSA-8949215	"Processing of SMDT1";"Mitochondrial calcium ion transport"
XP_046435888.1	3	Reactome: R-HSA-6807878;Reactome: R-HSA-8963901;Reactome: R-HSA-445095	"COPI-mediated anterograde transport";"Chylomicron remodeling";"Interaction between L1 and Ankyrins"
XP_046427163.1	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
XP_046422663.1	4	Reactome: R-HSA-159236;Reactome: R-HSA-72187;Reactome: R-HSA-72163;Reactome: R-HSA-73856	"Transport of Mature mRNA derived from an Intron-Containing Transcript";"mRNA 3'-end processing";"mRNA Splicing - Major Pathway";"RNA Polymerase II Transcription Termination"
XP_046433335.1	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276	"Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination"
XP_046421921.1	12	MetaCyc: PWY-8053;MetaCyc: PWY-7416;MetaCyc: PWY-7409;KEGG: 00564+3.1.1.4;MetaCyc: PWY-7417;KEGG: 00591+3.1.1.4;KEGG: 00565+3.1.1.4;MetaCyc: PWY-6803;MetaCyc: PWY-8051;KEGG: 00592+3.1.1.4;MetaCyc: PWY-7783;KEGG: 00590+3.1.1.4	"Anandamide biosynthesis II";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Glycerophospholipid metabolism";"Phospholipid remodeling (phosphatidate, yeast)";"Linoleic acid metabolism";"Ether lipid metabolism";"Phosphatidylcholine acyl editing";"Anandamide biosynthesis I";"alpha-Linolenic acid metabolism";"Plasmalogen degradation";"Arachidonic acid metabolism"
XP_046423344.1	2	Reactome: R-HSA-180024;KEGG: 00230+3.1.4.53	"DARPP-32 events";"Purine metabolism"
XP_046420860.1	33	Reactome: R-HSA-159227;Reactome: R-HSA-168333;Reactome: R-HSA-5663220;Reactome: R-HSA-5578749;Reactome: R-HSA-180746;Reactome: R-HSA-68877;Reactome: R-HSA-3301854;Reactome: R-HSA-4085377;Reactome: R-HSA-6784531;Reactome: R-HSA-165054;Reactome: R-HSA-170822;Reactome: R-HSA-180910;Reactome: R-HSA-159236;Reactome: R-HSA-141444;Reactome: R-HSA-168325;Reactome: R-HSA-9609690;Reactome: R-HSA-4570464;Reactome: R-HSA-168271;Reactome: R-HSA-191859;Reactome: R-HSA-159230;Reactome: R-HSA-4615885;Reactome: R-HSA-5619107;Reactome: R-HSA-168276;Reactome: R-HSA-4551638;Reactome: R-HSA-3232142;Reactome: R-HSA-2500257;Reactome: R-HSA-3371453;Reactome: R-HSA-9648025;Reactome: R-HSA-3108214;Reactome: R-HSA-1169408;Reactome: R-HSA-159231;Reactome: R-HSA-2467813;Reactome: R-HSA-9610379	"Transport of the SLBP independent Mature mRNA";"NEP/NS2 Interacts with the Cellular Export Machinery";"RHO GTPases Activate Formins";"Transcriptional regulation by small RNAs";"Nuclear import of Rev protein";"Mitotic Prometaphase";"Nuclear Pore Complex (NPC) Disassembly";"SUMOylation of SUMOylation proteins";"tRNA processing in the nucleus";"Rev-mediated nuclear export of HIV RNA";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Vpr-mediated nuclear import of PICs";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Viral Messenger RNA Synthesis";"HCMV Early Events";"SUMOylation of RNA binding proteins";"Transport of Ribonucleoproteins into the Host Nucleus";"snRNP Assembly";"Transport of the SLBP Dependant Mature mRNA";"SUMOylation of DNA replication proteins";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"NS1 Mediated Effects on Host Pathways";"SUMOylation of chromatin organization proteins";"SUMOylation of ubiquitinylation proteins";"Resolution of Sister Chromatid Cohesion";"Regulation of HSF1-mediated heat shock response";"EML4 and NUDC in mitotic spindle formation";"SUMOylation of DNA damage response and repair proteins";"ISG15 antiviral mechanism";"Transport of Mature mRNA Derived from an Intronless Transcript";"Separation of Sister Chromatids";"HCMV Late Events"
XP_046416584.1	5	Reactome: R-HSA-3270619;Reactome: R-HSA-3249367;Reactome: R-HSA-1834941;Reactome: R-HSA-6798695;Reactome: R-HSA-3134975	"IRF3-mediated induction of type I IFN";"STAT6-mediated induction of chemokines";"STING mediated induction of host immune responses";"Neutrophil degranulation";"Regulation of innate immune responses to cytosolic DNA"
XP_046417746.1	1	Reactome: R-HSA-201451	"Signaling by BMP"
XP_046426210.1	3	Reactome: R-HSA-194840;Reactome: R-HSA-416482;Reactome: R-HSA-193648	"Rho GTPase cycle";"G alpha (12/13) signalling events";"NRAGE signals death through JNK"
XP_046423453.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_046413930.1	4	Reactome: R-HSA-5696394;Reactome: R-HSA-8856825;Reactome: R-HSA-8951664;Reactome: R-HSA-6781823	"DNA Damage Recognition in GG-NER";"Cargo recognition for clathrin-mediated endocytosis";"Neddylation";"Formation of TC-NER Pre-Incision Complex"
XP_046433387.1	3	Reactome: R-HSA-193648;Reactome: R-HSA-416482;Reactome: R-HSA-194840	"NRAGE signals death through JNK";"G alpha (12/13) signalling events";"Rho GTPase cycle"
XP_046429302.1	1	Reactome: R-HSA-400253	"Circadian Clock"
XP_046417307.1	12	MetaCyc: PWY-6309;MetaCyc: PWY-601;MetaCyc: PWY-801;MetaCyc: PWY-7901;Reactome: R-HSA-71240;MetaCyc: PWY-6842;KEGG: 00270+4.4.1.13;MetaCyc: PWY-6936;MetaCyc: PWY-1187;KEGG: 00380+2.6.1.7;KEGG: 00450+4.4.1.13;MetaCyc: PWY-2821	"L-tryptophan degradation XI (mammalian, via kynurenine)";"Glucosinolate biosynthesis from tryptophan";"Homocysteine and cysteine interconversion";"Glucosinolate biosynthesis from tyrosine";"Tryptophan catabolism";"Glutathione-mediated detoxification II";"Cysteine and methionine metabolism";"Seleno-amino acid biosynthesis (plants)";"Glucosinolate biosynthesis from homomethionine";"Tryptophan metabolism";"Selenocompound metabolism";"Glucosinolate biosynthesis from phenylalanine"
XP_046425585.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046422055.1	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
XP_046425664.1	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
XP_046410131.1	6	MetaCyc: PWY-6368;KEGG: 00562+3.1.3.66;Reactome: R-HSA-1855183;Reactome: R-HSA-1660516;KEGG: 04070+3.1.3.66;Reactome: R-HSA-1660499	"3-phosphoinositide degradation";"Inositol phosphate metabolism";"Synthesis of IP2, IP, and Ins in the cytosol";"Synthesis of PIPs at the early endosome membrane";"Phosphatidylinositol signaling system";"Synthesis of PIPs at the plasma membrane"
XP_046434523.1	33	Reactome: R-HSA-168271;Reactome: R-HSA-191859;Reactome: R-HSA-159230;Reactome: R-HSA-4615885;Reactome: R-HSA-5619107;Reactome: R-HSA-168276;Reactome: R-HSA-4551638;Reactome: R-HSA-3232142;Reactome: R-HSA-2500257;Reactome: R-HSA-3371453;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813;Reactome: R-HSA-159231;Reactome: R-HSA-3108214;Reactome: R-HSA-1169408;Reactome: R-HSA-9610379;Reactome: R-HSA-159227;Reactome: R-HSA-168333;Reactome: R-HSA-5663220;Reactome: R-HSA-5578749;Reactome: R-HSA-180746;Reactome: R-HSA-68877;Reactome: R-HSA-3301854;Reactome: R-HSA-4085377;Reactome: R-HSA-165054;Reactome: R-HSA-6784531;Reactome: R-HSA-170822;Reactome: R-HSA-180910;Reactome: R-HSA-159236;Reactome: R-HSA-141444;Reactome: R-HSA-168325;Reactome: R-HSA-9609690;Reactome: R-HSA-4570464	"Transport of Ribonucleoproteins into the Host Nucleus";"snRNP Assembly";"Transport of the SLBP Dependant Mature mRNA";"SUMOylation of DNA replication proteins";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"NS1 Mediated Effects on Host Pathways";"SUMOylation of chromatin organization proteins";"SUMOylation of ubiquitinylation proteins";"Resolution of Sister Chromatid Cohesion";"Regulation of HSF1-mediated heat shock response";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids";"Transport of Mature mRNA Derived from an Intronless Transcript";"SUMOylation of DNA damage response and repair proteins";"ISG15 antiviral mechanism";"HCMV Late Events";"Transport of the SLBP independent Mature mRNA";"NEP/NS2 Interacts with the Cellular Export Machinery";"RHO GTPases Activate Formins";"Transcriptional regulation by small RNAs";"Nuclear import of Rev protein";"Mitotic Prometaphase";"Nuclear Pore Complex (NPC) Disassembly";"SUMOylation of SUMOylation proteins";"Rev-mediated nuclear export of HIV RNA";"tRNA processing in the nucleus";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Vpr-mediated nuclear import of PICs";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Viral Messenger RNA Synthesis";"HCMV Early Events";"SUMOylation of RNA binding proteins"
XP_046425268.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_046420869.1	33	Reactome: R-HSA-9610379;Reactome: R-HSA-1169408;Reactome: R-HSA-159231;Reactome: R-HSA-2467813;Reactome: R-HSA-3108214;Reactome: R-HSA-9648025;Reactome: R-HSA-3371453;Reactome: R-HSA-2500257;Reactome: R-HSA-3232142;Reactome: R-HSA-4551638;Reactome: R-HSA-168276;Reactome: R-HSA-5619107;Reactome: R-HSA-4615885;Reactome: R-HSA-159230;Reactome: R-HSA-191859;Reactome: R-HSA-168271;Reactome: R-HSA-4570464;Reactome: R-HSA-9609690;Reactome: R-HSA-168325;Reactome: R-HSA-141444;Reactome: R-HSA-159236;Reactome: R-HSA-180910;Reactome: R-HSA-170822;Reactome: R-HSA-165054;Reactome: R-HSA-4085377;Reactome: R-HSA-6784531;Reactome: R-HSA-3301854;Reactome: R-HSA-68877;Reactome: R-HSA-180746;Reactome: R-HSA-5578749;Reactome: R-HSA-5663220;Reactome: R-HSA-168333;Reactome: R-HSA-159227	"HCMV Late Events";"ISG15 antiviral mechanism";"Transport of Mature mRNA Derived from an Intronless Transcript";"Separation of Sister Chromatids";"SUMOylation of DNA damage response and repair proteins";"EML4 and NUDC in mitotic spindle formation";"Regulation of HSF1-mediated heat shock response";"Resolution of Sister Chromatid Cohesion";"SUMOylation of ubiquitinylation proteins";"SUMOylation of chromatin organization proteins";"NS1 Mediated Effects on Host Pathways";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"SUMOylation of DNA replication proteins";"Transport of the SLBP Dependant Mature mRNA";"snRNP Assembly";"Transport of Ribonucleoproteins into the Host Nucleus";"SUMOylation of RNA binding proteins";"HCMV Early Events";"Viral Messenger RNA Synthesis";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Vpr-mediated nuclear import of PICs";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Rev-mediated nuclear export of HIV RNA";"SUMOylation of SUMOylation proteins";"tRNA processing in the nucleus";"Nuclear Pore Complex (NPC) Disassembly";"Mitotic Prometaphase";"Nuclear import of Rev protein";"Transcriptional regulation by small RNAs";"RHO GTPases Activate Formins";"NEP/NS2 Interacts with the Cellular Export Machinery";"Transport of the SLBP independent Mature mRNA"
XP_046427901.1	2	Reactome: R-HSA-381340;Reactome: R-HSA-1989781	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression"
XP_046411657.1	2	Reactome: R-HSA-1169408;Reactome: R-HSA-168276	"ISG15 antiviral mechanism";"NS1 Mediated Effects on Host Pathways"
XP_046425426.1	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
XP_046436132.1	27	Reactome: R-HSA-4615885;Reactome: R-HSA-159230;Reactome: R-HSA-180746;Reactome: R-HSA-5578749;Reactome: R-HSA-191859;Reactome: R-HSA-168276;Reactome: R-HSA-5619107;Reactome: R-HSA-3301854;Reactome: R-HSA-168333;Reactome: R-HSA-159227;Reactome: R-HSA-168271;Reactome: R-HSA-9609690;Reactome: R-HSA-3108214;Reactome: R-HSA-1169408;Reactome: R-HSA-168325;Reactome: R-HSA-159231;Reactome: R-HSA-159236;Reactome: R-HSA-4570464;Reactome: R-HSA-9610379;Reactome: R-HSA-4551638;Reactome: R-HSA-6784531;Reactome: R-HSA-165054;Reactome: R-HSA-4085377;Reactome: R-HSA-180910;Reactome: R-HSA-3371453;Reactome: R-HSA-3232142;Reactome: R-HSA-170822	"SUMOylation of DNA replication proteins";"Transport of the SLBP Dependant Mature mRNA";"Nuclear import of Rev protein";"Transcriptional regulation by small RNAs";"snRNP Assembly";"NS1 Mediated Effects on Host Pathways";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Nuclear Pore Complex (NPC) Disassembly";"NEP/NS2 Interacts with the Cellular Export Machinery";"Transport of the SLBP independent Mature mRNA";"Transport of Ribonucleoproteins into the Host Nucleus";"HCMV Early Events";"SUMOylation of DNA damage response and repair proteins";"ISG15 antiviral mechanism";"Viral Messenger RNA Synthesis";"Transport of Mature mRNA Derived from an Intronless Transcript";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"SUMOylation of RNA binding proteins";"HCMV Late Events";"SUMOylation of chromatin organization proteins";"tRNA processing in the nucleus";"Rev-mediated nuclear export of HIV RNA";"SUMOylation of SUMOylation proteins";"Vpr-mediated nuclear import of PICs";"Regulation of HSF1-mediated heat shock response";"SUMOylation of ubiquitinylation proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein"
XP_046411905.1	2	Reactome: R-HSA-427413;Reactome: R-HSA-3214847	"NoRC negatively regulates rRNA expression";"HATs acetylate histones"
XP_046435376.1	2	Reactome: R-HSA-8856828;Reactome: R-HSA-8856825	"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis"
XP_046417638.1	1	Reactome: R-HSA-8943724	"Regulation of PTEN gene transcription"
XP_046434302.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_046430259.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_046413048.1	3	Reactome: R-HSA-3214858;Reactome: R-HSA-191859;Reactome: R-HSA-6804760	"RMTs methylate histone arginines";"snRNP Assembly";"Regulation of TP53 Activity through Methylation"
XP_046414594.1	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
XP_046421515.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046426495.1	7	KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1	"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Relaxin signaling pathway";"Thermogenesis";"Human cytomegalovirus infection"
XP_046421963.1	2	Reactome: R-HSA-1296052;Reactome: R-HSA-418457	"Ca2+ activated K+ channels";"cGMP effects"
XP_046432453.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046411654.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_046422531.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_046417211.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_046425725.1	13	Reactome: R-HSA-165159;Reactome: R-HSA-380972;Reactome: R-HSA-5674400;Reactome: R-HSA-1257604;Reactome: R-HSA-6804757;Reactome: R-HSA-1632852;Reactome: R-HSA-166208;Reactome: R-HSA-5218920;Reactome: R-HSA-5628897;Reactome: R-HSA-9639288;Reactome: R-HSA-8943724;Reactome: R-HSA-3371571;Reactome: R-HSA-389357	"mTOR signalling";"Energy dependent regulation of mTOR by LKB1-AMPK";"Constitutive Signaling by AKT1 E17K in Cancer";"PIP3 activates AKT signaling";"Regulation of TP53 Degradation";"Macroautophagy";"mTORC1-mediated signalling";"VEGFR2 mediated vascular permeability";"TP53 Regulates Metabolic Genes";"Amino acids regulate mTORC1";"Regulation of PTEN gene transcription";"HSF1-dependent transactivation";"CD28 dependent PI3K/Akt signaling"
XP_046433320.1	6	Reactome: R-HSA-6787450;MetaCyc: PWY-6829;MetaCyc: PWY-7285;Reactome: R-HSA-8868766;MetaCyc: PWY-7286;Reactome: R-HSA-6785470	"tRNA modification in the mitochondrion";"Trna methylation (yeast)";"Methylwyosine biosynthesis";"rRNA processing in the mitochondrion";"7-(3-amino-3-carboxypropyl)-wyosine biosynthesis";"tRNA processing in the mitochondrion"
XP_046421079.1	2	Reactome: R-HSA-72706;Reactome: R-HSA-72702	"GTP hydrolysis and joining of the 60S ribosomal subunit";"Ribosomal scanning and start codon recognition"
XP_046410843.1	1	Reactome: R-HSA-209968	"Thyroxine biosynthesis"
XP_046431941.1	12	KEGG: 00920+2.7.7.4;MetaCyc: PWY-6932;Reactome: R-HSA-174362;MetaCyc: PWY-6683;KEGG: 00230+2.7.1.25;KEGG: 00230+2.7.7.4;MetaCyc: PWY-5340;MetaCyc: PWY-5278;KEGG: 00261+2.7.7.4;KEGG: 00920+2.7.1.25;KEGG: 00450+2.7.7.4;Reactome: R-HSA-2408550	"Sulfur metabolism";"Selenate reduction";"Transport and synthesis of PAPS";"Assimilatory sulfate reduction III";"Purine metabolism";"Purine metabolism";"Sulfate activation for sulfonation";"Sulfite oxidation III";"Monobactam biosynthesis";"Sulfur metabolism";"Selenocompound metabolism";"Metabolism of ingested H2SeO4 and H2SeO3 into H2Se"
XP_046418686.1	3	Reactome: R-HSA-2995383;Reactome: R-HSA-2980766;Reactome: R-HSA-4419969	"Initiation of Nuclear Envelope Reformation";"Nuclear Envelope Breakdown";"Depolymerisation of the Nuclear Lamina"
XP_046423793.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_046428543.1	2	Reactome: R-HSA-1989781;Reactome: R-HSA-2151201	"PPARA activates gene expression";"Transcriptional activation of mitochondrial biogenesis"
XP_046411596.1	7	Reactome: R-HSA-749476;Reactome: R-HSA-1834949;Reactome: R-HSA-76071;Reactome: R-HSA-73780;Reactome: R-HSA-73980;Reactome: R-HSA-76066;Reactome: R-HSA-76061	"RNA Polymerase III Abortive And Retractive Initiation";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Chain Elongation";"RNA Polymerase III Transcription Termination";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Transcription Initiation From Type 1 Promoter"
XP_046418385.1	3	Reactome: R-HSA-416482;Reactome: R-HSA-194840;Reactome: R-HSA-193648	"G alpha (12/13) signalling events";"Rho GTPase cycle";"NRAGE signals death through JNK"
XP_046427818.1	4	Reactome: R-HSA-6799198;Reactome: R-HSA-611105;Reactome: R-HSA-77289;Reactome: R-HSA-389661	"Complex I biogenesis";"Respiratory electron transport";"Mitochondrial Fatty Acid Beta-Oxidation";"Glyoxylate metabolism and glycine degradation"
XP_046435520.1	6	Reactome: R-HSA-156827;Reactome: R-HSA-72689;Reactome: R-HSA-72649;Reactome: R-HSA-72695;Reactome: R-HSA-72702;Reactome: R-HSA-72706	"L13a-mediated translational silencing of Ceruloplasmin expression";"Formation of a pool of free 40S subunits";"Translation initiation complex formation";"Formation of the ternary complex, and subsequently, the 43S complex";"Ribosomal scanning and start codon recognition";"GTP hydrolysis and joining of the 60S ribosomal subunit"
XP_046417052.1	2	Reactome: R-HSA-383280;Reactome: R-HSA-983231	"Nuclear Receptor transcription pathway";"Factors involved in megakaryocyte development and platelet production"
XP_046425821.1	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_046428473.1	3	Reactome: R-HSA-2206291;Reactome: R-HSA-2024096;Reactome: R-HSA-6798695	"MPS IIIC - Sanfilippo syndrome C";"HS-GAG degradation";"Neutrophil degranulation"
XP_046421256.1	1	Reactome: R-HSA-6804756	"Regulation of TP53 Activity through Phosphorylation"
XP_046429424.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046421624.1	3	KEGG: 04070+2.7.4.24+2.7.4.21;Reactome: R-HSA-1855167;MetaCyc: PWY-6369	"Phosphatidylinositol signaling system";"Synthesis of pyrophosphates in the cytosol";"Inositol diphosphates biosynthesis"
XP_046432154.1	1	Reactome: R-HSA-390522	"Striated Muscle Contraction"
XP_046434500.1	2	MetaCyc: PWY-6938;Reactome: R-HSA-430039	"NADH repair";"mRNA decay by 5' to 3' exoribonuclease"
XP_046414641.1	14	MetaCyc: PWY-6453;MetaCyc: PWY-8051;KEGG: 00564+2.3.1.51;MetaCyc: PWY-8055;KEGG: 00561+2.3.1.51;MetaCyc: PWY-5667;Reactome: R-HSA-1483166;MetaCyc: PWY-7411;MetaCyc: PWY-7587;MetaCyc: PWY-7782;MetaCyc: PWY-7589;MetaCyc: PWY-8053;MetaCyc: PWY-5981;MetaCyc: PWY-7417	"Stigma estolide biosynthesis";"Anandamide biosynthesis I";"Glycerophospholipid metabolism";"Palmitoyl ethanolamide biosynthesis";"Glycerolipid metabolism";"CDP-diacylglycerol biosynthesis I";"Synthesis of PA";"Phosphatidate biosynthesis (yeast)";"Oleate biosynthesis III (cyanobacteria)";"Plasmalogen biosynthesis";"Palmitoleate biosynthesis III (cyanobacteria)";"Anandamide biosynthesis II";"CDP-diacylglycerol biosynthesis III";"Phospholipid remodeling (phosphatidate, yeast)"
XP_046411831.1	8	KEGG: 00640+1.1.1.27;Reactome: R-HSA-70268;MetaCyc: PWY-8086;MetaCyc: PWY-5481;KEGG: 00270+1.1.1.27;KEGG: 00620+1.1.1.27;KEGG: 00010+1.1.1.27;MetaCyc: PWY-6901	"Propanoate metabolism";"Pyruvate metabolism";"(S)-lactate fermentation to propanoate, acetate and hydrogen";"Pyruvate fermentation to (S)-lactate";"Cysteine and methionine metabolism";"Pyruvate metabolism";"Glycolysis / Gluconeogenesis";"Superpathway of glucose and xylose degradation"
XP_046418948.1	14	MetaCyc: PWY-7587;Reactome: R-HSA-1483166;MetaCyc: PWY-7411;MetaCyc: PWY-5667;KEGG: 00564+2.3.1.51;MetaCyc: PWY-8051;MetaCyc: PWY-6453;KEGG: 00561+2.3.1.51;MetaCyc: PWY-8055;MetaCyc: PWY-7417;MetaCyc: PWY-5981;MetaCyc: PWY-8053;MetaCyc: PWY-7782;MetaCyc: PWY-7589	"Oleate biosynthesis III (cyanobacteria)";"Synthesis of PA";"Phosphatidate biosynthesis (yeast)";"CDP-diacylglycerol biosynthesis I";"Glycerophospholipid metabolism";"Anandamide biosynthesis I";"Stigma estolide biosynthesis";"Glycerolipid metabolism";"Palmitoyl ethanolamide biosynthesis";"Phospholipid remodeling (phosphatidate, yeast)";"CDP-diacylglycerol biosynthesis III";"Anandamide biosynthesis II";"Plasmalogen biosynthesis";"Palmitoleate biosynthesis III (cyanobacteria)"
XP_046421350.1	1	Reactome: R-HSA-9037629	"Lewis blood group biosynthesis"
XP_046431910.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046427462.1	5	KEGG: 00520+3.2.1.14;Reactome: R-HSA-189085;MetaCyc: PWY-6855;MetaCyc: PWY-6902;MetaCyc: PWY-7822	"Amino sugar and nucleotide sugar metabolism";"Digestion of dietary carbohydrate";"Chitin degradation I (archaea)";"Chitin degradation II (Vibrio)";"Chitin degradation III (Serratia)"
XP_046410041.1	1	Reactome: R-HSA-196108	"Pregnenolone biosynthesis"
XP_046430049.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046427393.1	1	KEGG: 04660+2.7.10.2	"T cell receptor signaling pathway"
XP_046419804.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046421010.1	6	MetaCyc: PWY-5884;MetaCyc: PWY-7782;KEGG: 00073+1.2.1.84;MetaCyc: PWY-7656;Reactome: R-HSA-9640463;MetaCyc: PWY-6733	"Wax esters biosynthesis I";"Plasmalogen biosynthesis";"Cutin, suberine and wax biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Wax biosynthesis";"Sporopollenin precursors biosynthesis"
XP_046425429.1	2	Reactome: R-HSA-375280;Reactome: R-HSA-416476	"Amine ligand-binding receptors";"G alpha (q) signalling events"
XP_046423934.1	3	Reactome: R-HSA-264876;Reactome: R-HSA-5620916;Reactome: R-HSA-1445148	"Insulin processing";"VxPx cargo-targeting to cilium";"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
XP_046410644.1	1	Reactome: R-HSA-8949664	"Processing of SMDT1"
XP_046416922.1	14	Reactome: R-HSA-975634;KEGG: 00590+3.1.1.4;MetaCyc: PWY-7783;KEGG: 00592+3.1.1.4;KEGG: 00564+3.1.1.4+3.1.1.5;MetaCyc: PWY-8051;Reactome: R-HSA-1482788;MetaCyc: PWY-6803;KEGG: 00565+3.1.1.4;KEGG: 00591+3.1.1.4;MetaCyc: PWY-7417;MetaCyc: PWY-7409;MetaCyc: PWY-7416;MetaCyc: PWY-8053	"Retinoid metabolism and transport";"Arachidonic acid metabolism";"Plasmalogen degradation";"alpha-Linolenic acid metabolism";"Glycerophospholipid metabolism";"Anandamide biosynthesis I";"Acyl chain remodelling of PC";"Phosphatidylcholine acyl editing";"Ether lipid metabolism";"Linoleic acid metabolism";"Phospholipid remodeling (phosphatidate, yeast)";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Anandamide biosynthesis II"
XP_046434997.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046425943.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_046418162.1	1	Reactome: R-HSA-975957	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
XP_046435596.1	3	Reactome: R-HSA-191859;Reactome: R-HSA-72163;Reactome: R-HSA-72165	"snRNP Assembly";"mRNA Splicing - Major Pathway";"mRNA Splicing - Minor Pathway"
XP_046424942.1	3	KEGG: 00970+6.1.1.20;Reactome: R-HSA-2408522;Reactome: R-HSA-379716	"Aminoacyl-tRNA biosynthesis";"Selenoamino acid metabolism";"Cytosolic tRNA aminoacylation"
XP_046414572.1	1	Reactome: R-HSA-1660661	"Sphingolipid de novo biosynthesis"
XP_046427641.1	1	KEGG: 00970+6.3.5.7	"Aminoacyl-tRNA biosynthesis"
XP_046423270.1	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
XP_046426602.1	3	Reactome: R-HSA-749476;Reactome: R-HSA-76061;Reactome: R-HSA-76066	"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Transcription Initiation From Type 2 Promoter"
XP_046427754.1	1	Reactome: R-HSA-1614517	"Sulfide oxidation to sulfate"
XP_046421692.1	3	Reactome: R-HSA-212436;Reactome: R-HSA-381340;Reactome: R-HSA-1989781	"Generic Transcription Pathway";"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression"
XP_046413962.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046424796.1	7	Reactome: R-HSA-380259;Reactome: R-HSA-8854518;Reactome: R-HSA-2565942;Reactome: R-HSA-380270;Reactome: R-HSA-380320;Reactome: R-HSA-5620912;Reactome: R-HSA-380284	"Loss of Nlp from mitotic centrosomes";"AURKA Activation by TPX2";"Regulation of PLK1 Activity at G2/M Transition";"Recruitment of mitotic centrosome proteins and complexes";"Recruitment of NuMA to mitotic centrosomes";"Anchoring of the basal body to the plasma membrane";"Loss of proteins required for interphase microtubule organization from the centrosome"
XP_046424592.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046425049.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_046431514.1	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
XP_046429273.1	1	Reactome: R-HSA-8856828	"Clathrin-mediated endocytosis"
XP_046433769.1	1	Reactome: R-HSA-5666185	"RHO GTPases Activate Rhotekin and Rhophilins"
XP_046415417.1	2	Reactome: R-HSA-5578998;Reactome: R-HSA-174403	"Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD)";"Glutathione synthesis and recycling"
XP_046426475.1	2	Reactome: R-HSA-5619039;Reactome: R-HSA-426117	"Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)";"Cation-coupled Chloride cotransporters"
XP_046416109.1	5	Reactome: R-HSA-5693554;Reactome: R-HSA-5693616;Reactome: R-HSA-5685942;Reactome: R-HSA-5693579;Reactome: R-HSA-5693568	"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Presynaptic phase of homologous DNA pairing and strand exchange";"HDR through Homologous Recombination (HRR)";"Homologous DNA Pairing and Strand Exchange";"Resolution of D-loop Structures through Holliday Junction Intermediates"
XP_046424974.1	1	Reactome: R-HSA-6784531	"tRNA processing in the nucleus"
XP_046431541.1	57	Reactome: R-HSA-450408;Reactome: R-HSA-5610780;Reactome: R-HSA-1236974;Reactome: R-HSA-211733;Reactome: R-HSA-4641258;Reactome: R-HSA-5632684;Reactome: R-HSA-8941858;Reactome: R-HSA-9010553;Reactome: R-HSA-350562;Reactome: R-HSA-5668541;Reactome: R-HSA-5676590;Reactome: R-HSA-9604323;Reactome: R-HSA-5362768;Reactome: R-HSA-5358346;Reactome: R-HSA-69601;Reactome: R-HSA-69017;Reactome: R-HSA-1169091;Reactome: R-HSA-382556;Reactome: R-HSA-68949;Reactome: R-HSA-195253;Reactome: R-HSA-2871837;Reactome: R-HSA-174178;Reactome: R-HSA-8854050;Reactome: R-HSA-9020702;Reactome: R-HSA-174113;Reactome: R-HSA-5687128;Reactome: R-HSA-68827;Reactome: R-HSA-5689603;Reactome: R-HSA-180534;Reactome: R-HSA-187577;Reactome: R-HSA-5607764;Reactome: R-HSA-69481;Reactome: R-HSA-1234176;Reactome: R-HSA-8948751;Reactome: R-HSA-5610783;Reactome: R-HSA-8852276;Reactome: R-HSA-5607761;Reactome: R-HSA-5658442;Reactome: R-HSA-983168;Reactome: R-HSA-6798695;Reactome: R-HSA-174154;Reactome: R-HSA-8939902;Reactome: R-HSA-174184;Reactome: R-HSA-2467813;Reactome: R-HSA-174084;Reactome: R-HSA-5689880;Reactome: R-HSA-8951664;Reactome: R-HSA-349425;Reactome: R-HSA-1236978;Reactome: R-HSA-75815;Reactome: R-HSA-202424;Reactome: R-HSA-4608870;Reactome: R-HSA-4641257;Reactome: R-HSA-5678895;Reactome: R-HSA-180585;Reactome: R-HSA-5610785;Reactome: R-HSA-8939236	"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Degradation of GLI1 by the proteasome";"ER-Phagosome pathway";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Degradation of DVL";"Hedgehog 'on' state";"Regulation of RUNX3 expression and activity";"Regulation of expression of SLITs and ROBOs";"Regulation of ornithine decarboxylase (ODC)";"TNFR2 non-canonical NF-kB pathway";"NIK-->noncanonical NF-kB signaling";"Negative regulation of NOTCH4 signaling";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Hedgehog ligand biogenesis";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"CDK-mediated phosphorylation and removal of Cdc6";"Activation of NF-kappaB in B cells";"ABC-family proteins mediated transport";"Orc1 removal from chromatin";"Degradation of beta-catenin by the destruction complex";"FCERI mediated NF-kB activation";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Interleukin-1 signaling";"SCF-beta-TrCP mediated degradation of Emi1";"MAPK6/MAPK4 signaling";"CDT1 association with the CDC6:ORC:origin complex";"UCH proteinases";"Vpu mediated degradation of CD4";"SCF(Skp2)-mediated degradation of p27/p21";"CLEC7A (Dectin-1) signaling";"G2/M Checkpoints";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of PTEN stability and activity";"Degradation of GLI2 by the proteasome";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Dectin-1 mediated noncanonical NF-kB signaling";"Regulation of RAS by GAPs";"Antigen processing: Ubiquitination & Proteasome degradation";"Neutrophil degranulation";"APC/C:Cdc20 mediated degradation of Securin";"Regulation of RUNX2 expression and activity";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Separation of Sister Chromatids";"Autodegradation of Cdh1 by Cdh1:APC/C";"Ub-specific processing proteases";"Neddylation";"Autodegradation of the E3 ubiquitin ligase COP1";"Cross-presentation of soluble exogenous antigens (endosomes)";"Ubiquitin-dependent degradation of Cyclin D";"Downstream TCR signaling";"Asymmetric localization of PCP proteins";"Degradation of AXIN";"Defective CFTR causes cystic fibrosis";"Vif-mediated degradation of APOBEC3G";"GLI3 is processed to GLI3R by the proteasome";"RUNX1 regulates transcription of genes involved in differentiation of HSCs"
XP_046430862.1	1	Reactome: R-HSA-6809371	"Formation of the cornified envelope"
XP_046412906.1	15	Reactome: R-HSA-113418;Reactome: R-HSA-112382;Reactome: R-HSA-167238;Reactome: R-HSA-167243;Reactome: R-HSA-167246;Reactome: R-HSA-9603505;Reactome: R-HSA-75955;Reactome: R-HSA-167290;Reactome: R-HSA-167152;Reactome: R-HSA-674695;Reactome: R-HSA-167242;Reactome: R-HSA-167158;Reactome: R-HSA-167287;Reactome: R-HSA-167200;Reactome: R-HSA-6796648	"Formation of the Early Elongation Complex";"Formation of RNA Pol II elongation complex";"Pausing and recovery of Tat-mediated HIV elongation";"Tat-mediated HIV elongation arrest and recovery";"Tat-mediated elongation of the HIV-1 transcript";"NTRK3 as a dependence receptor";"RNA Polymerase II Transcription Elongation";"Pausing and recovery of HIV elongation";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Polymerase II Pre-transcription Events";"Abortive elongation of HIV-1 transcript in the absence of Tat";"Formation of the HIV-1 Early Elongation Complex";"HIV elongation arrest and recovery";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"TP53 Regulates Transcription of DNA Repair Genes"
XP_046420187.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_046432732.1	7	Reactome: R-HSA-5620912;Reactome: R-HSA-380284;Reactome: R-HSA-380320;Reactome: R-HSA-2565942;Reactome: R-HSA-380270;Reactome: R-HSA-8854518;Reactome: R-HSA-380259	"Anchoring of the basal body to the plasma membrane";"Loss of proteins required for interphase microtubule organization from the centrosome";"Recruitment of NuMA to mitotic centrosomes";"Regulation of PLK1 Activity at G2/M Transition";"Recruitment of mitotic centrosome proteins and complexes";"AURKA Activation by TPX2";"Loss of Nlp from mitotic centrosomes"
XP_046412413.1	5	Reactome: R-HSA-199220;Reactome: R-HSA-2426168;Reactome: R-HSA-163765;Reactome: R-HSA-9029558;Reactome: R-HSA-75105	"Vitamin B5 (pantothenate) metabolism";"Activation of gene expression by SREBF (SREBP)";"ChREBP activates metabolic gene expression";"NR1H2 & NR1H3 regulate gene expression linked to lipogenesis";"Fatty acyl-CoA biosynthesis"
XP_046431121.1	2	Reactome: R-HSA-390522;Reactome: R-HSA-445355	"Striated Muscle Contraction";"Smooth Muscle Contraction"
XP_046425118.1	10	Reactome: R-HSA-437239;Reactome: R-HSA-442742;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;Reactome: R-HSA-444257;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1	"Recycling pathway of L1";"CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling";"Thermogenesis";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"RSK activation";"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Human cytomegalovirus infection";"Relaxin signaling pathway"
XP_046430110.1	1	Reactome: R-HSA-6790901	"rRNA modification in the nucleus and cytosol"
XP_046435166.1	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
XP_046425427.1	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
XP_046409643.1	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
XP_046413700.1	9	Reactome: R-HSA-5628897;Reactome: R-HSA-8943724;Reactome: R-HSA-9639288;Reactome: R-HSA-5674135;Reactome: R-HSA-165159;Reactome: R-HSA-380972;Reactome: R-HSA-1632852;Reactome: R-HSA-6798695;Reactome: R-HSA-166208	"TP53 Regulates Metabolic Genes";"Regulation of PTEN gene transcription";"Amino acids regulate mTORC1";"MAP2K and MAPK activation";"mTOR signalling";"Energy dependent regulation of mTOR by LKB1-AMPK";"Macroautophagy";"Neutrophil degranulation";"mTORC1-mediated signalling"
XP_046427449.1	11	MetaCyc: PWY-7586;KEGG: 00051+5.3.1.8;MetaCyc: PWY-7456;MetaCyc: PWY-5659;MetaCyc: PWY-6992;MetaCyc: PWY-3861;Reactome: R-HSA-446205;MetaCyc: PWY-3881;KEGG: 00520+5.3.1.8;MetaCyc: PWY-882;Reactome: R-HSA-4043916	"Beta-1,4-d-mannosyl-n-acetyl-d-glucosamine degradation";"Fructose and mannose metabolism";"Beta-(1,4)-mannan degradation";"GDP-mannose biosynthesis";"1,5-anhydrofructose degradation";"Mannitol degradation II";"Synthesis of GDP-mannose";"Mannitol biosynthesis";"Amino sugar and nucleotide sugar metabolism";"L-ascorbate biosynthesis I (L-galactose pathway)";"Defective MPI causes MPI-CDG (CDG-1b)"
XP_046414912.1	1	Reactome: R-HSA-350562	"Regulation of ornithine decarboxylase (ODC)"
XP_046412866.1	4	KEGG: 00983+6.3.5.2;MetaCyc: PWY-7221;KEGG: 00230+6.3.5.2;Reactome: R-HSA-73817	"Drug metabolism - other enzymes";"Guanosine ribonucleotides de novo biosynthesis";"Purine metabolism";"Purine ribonucleoside monophosphate biosynthesis"
XP_046419847.1	3	KEGG: 00730+3.1.3.2;MetaCyc: PWY-6348;KEGG: 00740+3.1.3.2	"Thiamine metabolism";"Phosphate acquisition";"Riboflavin metabolism"
XP_046409754.1	1	Reactome: R-HSA-6803157	"Antimicrobial peptides"
XP_046415801.1	18	MetaCyc: PWY-5392;MetaCyc: PWY-561;MetaCyc: PWY-8086;KEGG: 00270+1.1.1.37;MetaCyc: PWY-7115;MetaCyc: PWY-7383;MetaCyc: PWY-5913;KEGG: 00630+1.1.1.37;KEGG: 00020+1.1.1.37;MetaCyc: PWY-5690;MetaCyc: PWY-1622;Reactome: R-HSA-70263;KEGG: 00720+1.1.1.37;KEGG: 00710+1.1.1.37;MetaCyc: PWY-6969;MetaCyc: PWY-6728;KEGG: 00680+1.1.1.37;KEGG: 00620+1.1.1.37	"Reductive TCA cycle II";"Superpathway of glyoxylate cycle and fatty acid degradation";"(S)-lactate fermentation to propanoate, acetate and hydrogen";"Cysteine and methionine metabolism";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"Anaerobic energy metabolism (invertebrates, cytosol)";"Partial TCA cycle (obligate autotrophs)";"Glyoxylate and dicarboxylate metabolism";"Citrate cycle (TCA cycle)";"TCA cycle II (plants and fungi)";"Formaldehyde assimilation I (serine pathway)";"Gluconeogenesis";"Carbon fixation pathways in prokaryotes";"Carbon fixation in photosynthetic organisms";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Methylaspartate cycle";"Methane metabolism";"Pyruvate metabolism"
XP_046435901.1	2	Reactome: R-HSA-445095;Reactome: R-HSA-6807878	"Interaction between L1 and Ankyrins";"COPI-mediated anterograde transport"
XP_046425354.1	5	KEGG: 00860+2.3.1.37;MetaCyc: PWY-7536;KEGG: 00260+2.3.1.37;MetaCyc: PWY-5189;Reactome: R-HSA-189451	"Porphyrin and chlorophyll metabolism";"2-amino-3-hydroxycyclopent-2-enone biosynthesis";"Glycine, serine and threonine metabolism";"Tetrapyrrole biosynthesis II (from glycine)";"Heme biosynthesis"
XP_046413084.1	1	KEGG: 00760+2.3.1.286	"Nicotinate and nicotinamide metabolism"
XP_046410982.1	1	Reactome: R-HSA-71403	"Citric acid cycle (TCA cycle)"
XP_046418994.1	1	Reactome: R-HSA-5576886	"Phase 4 - resting membrane potential"
XP_046435667.1	2	Reactome: R-HSA-5628897;Reactome: R-HSA-611105	"TP53 Regulates Metabolic Genes";"Respiratory electron transport"
XP_046432743.1	5	Reactome: R-HSA-5673001;Reactome: R-HSA-6811558;Reactome: R-HSA-1257604;Reactome: R-HSA-109704;Reactome: R-HSA-2219530	"RAF/MAP kinase cascade";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"PIP3 activates AKT signaling";"PI3K Cascade";"Constitutive Signaling by Aberrant PI3K in Cancer"
XP_046421477.1	1	Reactome: R-HSA-435368	"Zinc efflux and compartmentalization by the SLC30 family"
XP_046421626.1	3	KEGG: 04070+2.7.4.24+2.7.4.21;MetaCyc: PWY-6369;Reactome: R-HSA-1855167	"Phosphatidylinositol signaling system";"Inositol diphosphates biosynthesis";"Synthesis of pyrophosphates in the cytosol"
XP_046428550.1	2	KEGG: 00260+2.1.2.10;KEGG: 00670+2.1.2.10	"Glycine, serine and threonine metabolism";"One carbon pool by folate"
XP_046425187.1	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
XP_046411090.1	3	Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-9018519	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"Estrogen-dependent gene expression"
XP_046430666.1	1	Reactome: R-HSA-2564830	"Cytosolic iron-sulfur cluster assembly"
XP_046430154.1	5	Reactome: R-HSA-70171;MetaCyc: PWY-6906;MetaCyc: PWY-5514;KEGG: 00520+3.5.99.6;MetaCyc: PWY-6855	"Glycolysis";"Chitin derivatives degradation";"UDP-N-acetyl-D-galactosamine biosynthesis II";"Amino sugar and nucleotide sugar metabolism";"Chitin degradation I (archaea)"
XP_046413929.1	4	Reactome: R-HSA-8951664;Reactome: R-HSA-6781823;Reactome: R-HSA-5696394;Reactome: R-HSA-8856825	"Neddylation";"Formation of TC-NER Pre-Incision Complex";"DNA Damage Recognition in GG-NER";"Cargo recognition for clathrin-mediated endocytosis"
XP_046428306.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046416296.1	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
XP_046427894.1	13	Reactome: R-HSA-192823;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-72689;Reactome: R-HSA-1799339;Reactome: R-HSA-2408557;Reactome: R-HSA-72706;Reactome: R-HSA-6791226;Reactome: R-HSA-975957;Reactome: R-HSA-72764;Reactome: R-HSA-975956;Reactome: R-HSA-156902	"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Formation of a pool of free 40S subunits";"SRP-dependent cotranslational protein targeting to membrane";"Selenocysteine synthesis";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Peptide chain elongation"
XP_046417819.1	7	KEGG: 00562+3.1.3.25;Reactome: R-HSA-1855183;KEGG: 04070+3.1.3.25;MetaCyc: PWY-2301;MetaCyc: PWY-4702;KEGG: 00521+3.1.3.25;MetaCyc: PWY-6363	"Inositol phosphate metabolism";"Synthesis of IP2, IP, and Ins in the cytosol";"Phosphatidylinositol signaling system";"Myo-inositol biosynthesis";"Phytate degradation I";"Streptomycin biosynthesis";"D-myo-inositol (1,4,5)-trisphosphate degradation"
XP_046418356.1	5	Reactome: R-HSA-3134975;Reactome: R-HSA-6798695;Reactome: R-HSA-1834941;Reactome: R-HSA-3270619;Reactome: R-HSA-3249367	"Regulation of innate immune responses to cytosolic DNA";"Neutrophil degranulation";"STING mediated induction of host immune responses";"IRF3-mediated induction of type I IFN";"STAT6-mediated induction of chemokines"
XP_046427623.1	2	KEGG: 00500+3.2.1.28;Reactome: R-HSA-189085	"Starch and sucrose metabolism";"Digestion of dietary carbohydrate"
XP_046430100.1	6	Reactome: R-HSA-72649;Reactome: R-HSA-72706;Reactome: R-HSA-72695;Reactome: R-HSA-72702;Reactome: R-HSA-156827;Reactome: R-HSA-72689	"Translation initiation complex formation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Formation of the ternary complex, and subsequently, the 43S complex";"Ribosomal scanning and start codon recognition";"L13a-mediated translational silencing of Ceruloplasmin expression";"Formation of a pool of free 40S subunits"
XP_046418915.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046430091.1	3	MetaCyc: PWY-6823;KEGG: 00790+2.10.1.1;Reactome: R-HSA-947581	"Molybdenum cofactor biosynthesis";"Folate biosynthesis";"Molybdenum cofactor biosynthesis"
XP_046436610.1	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
XP_046410646.1	1	Reactome: R-HSA-8949664	"Processing of SMDT1"
XP_046420908.1	2	Reactome: R-HSA-3214841;Reactome: R-HSA-8936459	"PKMTs methylate histone lysines";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"
XP_046419854.1	19	Reactome: R-HSA-6802955;Reactome: R-HSA-6802952;Reactome: R-HSA-9649948;Reactome: R-HSA-3371571;Reactome: R-HSA-442982;Reactome: R-HSA-9620244;Reactome: R-HSA-6802946;Reactome: R-HSA-5673000;Reactome: R-HSA-5673001;Reactome: R-HSA-399719;Reactome: R-HSA-5578775;Reactome: R-HSA-936837;Reactome: R-HSA-9609736;Reactome: R-HSA-9617324;Reactome: R-HSA-5576892;Reactome: R-HSA-877300;Reactome: R-HSA-9022692;Reactome: R-HSA-111932;Reactome: R-HSA-438066	"Paradoxical activation of RAF signaling by kinase inactive BRAF";"Signaling by BRAF and RAF fusions";"Signaling downstream of RAS mutants";"HSF1-dependent transactivation";"Ras activation upon Ca2+ influx through NMDA receptor";"Long-term potentiation";"Signaling by moderate kinase activity BRAF mutants";"RAF activation";"RAF/MAP kinase cascade";"Trafficking of AMPA receptors";"Ion homeostasis";"Ion transport by P-type ATPases";"Assembly and cell surface presentation of NMDA receptors";"Negative regulation of NMDA receptor-mediated neuronal transmission";"Phase 0 - rapid depolarisation";"Interferon gamma signaling";"Regulation of MECP2 expression and activity";"CaMK IV-mediated phosphorylation of CREB";"Unblocking of NMDA receptors, glutamate binding and activation"
XP_046418125.1	1	Reactome: R-HSA-5610787	"Hedgehog 'off' state"
XP_046418372.1	2	Reactome: R-HSA-5693568;Reactome: R-HSA-6783310	"Resolution of D-loop Structures through Holliday Junction Intermediates";"Fanconi Anemia Pathway"
XP_046410581.1	2	Reactome: R-HSA-5218920;Reactome: R-HSA-418990	"VEGFR2 mediated vascular permeability";"Adherens junctions interactions"
XP_046433134.1	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
XP_046429267.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046423025.1	7	Reactome: R-HSA-375165;Reactome: R-HSA-6807878;Reactome: R-HSA-6798695;Reactome: R-HSA-445095;Reactome: R-HSA-264870;Reactome: R-HSA-373753;Reactome: R-HSA-5673001	"NCAM signaling for neurite out-growth";"COPI-mediated anterograde transport";"Neutrophil degranulation";"Interaction between L1 and Ankyrins";"Caspase-mediated cleavage of cytoskeletal proteins";"Nephrin family interactions";"RAF/MAP kinase cascade"
XP_046420697.1	1	Reactome: R-HSA-169911	"Regulation of Apoptosis"
XP_046414183.1	1	Reactome: R-HSA-1660662	"Glycosphingolipid metabolism"
XP_046433596.1	1	Reactome: R-HSA-2024096	"HS-GAG degradation"
XP_046431497.1	4	Reactome: R-HSA-3371568;Reactome: R-HSA-9018519;Reactome: R-HSA-3371497;Reactome: R-HSA-8939211	"Attenuation phase";"Estrogen-dependent gene expression";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"ESR-mediated signaling"
XP_046430419.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046436248.1	2	Reactome: R-HSA-2022928;MetaCyc: PWY-6558	"HS-GAG biosynthesis";"Heparan sulfate biosynthesis (late stages)"
XP_046413292.1	4	Reactome: R-HSA-4641257;Reactome: R-HSA-201681;Reactome: R-HSA-5689880;Reactome: R-HSA-418594	"Degradation of AXIN";"TCF dependent signaling in response to WNT";"Ub-specific processing proteases";"G alpha (i) signalling events"
XP_046431035.1	3	Reactome: R-HSA-375276;Reactome: R-HSA-416476;Reactome: R-HSA-418594	"Peptide ligand-binding receptors";"G alpha (q) signalling events";"G alpha (i) signalling events"
XP_046434791.1	1	Reactome: R-HSA-163560	"Triglyceride catabolism"
XP_046419249.1	1	Reactome: R-HSA-352230	"Amino acid transport across the plasma membrane"
XP_046429525.1	2	Reactome: R-HSA-5357905;Reactome: R-HSA-8876198	"Regulation of TNFR1 signaling";"RAB GEFs exchange GTP for GDP on RABs"
XP_046415114.1	5	Reactome: R-HSA-427413;Reactome: R-HSA-5250924;Reactome: R-HSA-73772;Reactome: R-HSA-73762;Reactome: R-HSA-73863	"NoRC negatively regulates rRNA expression";"B-WICH complex positively regulates rRNA expression";"RNA Polymerase I Promoter Escape";"RNA Polymerase I Transcription Initiation";"RNA Polymerase I Transcription Termination"
XP_046414489.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_046423573.1	2	KEGG: 00970+6.1.1.10;KEGG: 00450+6.1.1.10	"Aminoacyl-tRNA biosynthesis";"Selenocompound metabolism"
XP_046410517.1	5	MetaCyc: PWY-7269;KEGG: 00760+2.7.1.23;MetaCyc: PWY-7268;Reactome: R-HSA-196807;MetaCyc: PWY-5083	"NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)";"Nicotinate and nicotinamide metabolism";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"Nicotinate metabolism";"NAD/NADH phosphorylation and dephosphorylation"
XP_046432983.1	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276	"Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination"
XP_046434436.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046409577.1	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
XP_046431329.1	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
XP_046410829.1	6	Reactome: R-HSA-8986944;Reactome: R-HSA-452723;Reactome: R-HSA-6785807;Reactome: R-HSA-3769402;Reactome: R-HSA-2892245;Reactome: R-HSA-2892247	"Transcriptional Regulation by MECP2";"Transcriptional regulation of pluripotent stem cells";"Interleukin-4 and Interleukin-13 signaling";"Deactivation of the beta-catenin transactivating complex";"POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation";"POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation"
XP_046418233.1	3	Reactome: R-HSA-212436;Reactome: R-HSA-381340;Reactome: R-HSA-1989781	"Generic Transcription Pathway";"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression"
XP_046432029.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_046433419.1	14	Reactome: R-HSA-611105;KEGG: 00650+1.3.5.1;KEGG: 00190+1.3.5.1;KEGG: 00020+1.3.5.1;KEGG: 00720+1.3.5.1;MetaCyc: PWY-7279;MetaCyc: PWY-5690;Reactome: R-HSA-71403;MetaCyc: PWY-3781;MetaCyc: PWY-561;MetaCyc: PWY-4302;MetaCyc: PWY-7254;MetaCyc: PWY-6728;MetaCyc: PWY-6969	"Respiratory electron transport";"Butanoate metabolism";"Oxidative phosphorylation";"Citrate cycle (TCA cycle)";"Carbon fixation pathways in prokaryotes";"Aerobic respiration II (cytochrome c) (yeast)";"TCA cycle II (plants and fungi)";"Citric acid cycle (TCA cycle)";"Aerobic respiration I (cytochrome c)";"Superpathway of glyoxylate cycle and fatty acid degradation";"Aerobic respiration III (alternative oxidase pathway)";"TCA cycle VII (acetate-producers)";"Methylaspartate cycle";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)"
XP_046425355.1	2	Reactome: R-HSA-162588;Reactome: R-HSA-917729	"Budding and maturation of HIV virion";"Endosomal Sorting Complex Required For Transport (ESCRT)"
XP_046424071.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_046434715.1	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
XP_046430113.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046422822.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046414965.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_046414537.1	6	Reactome: R-HSA-5685938;Reactome: R-HSA-5693607;Reactome: R-HSA-176187;Reactome: R-HSA-5693616;Reactome: R-HSA-69473;Reactome: R-HSA-6804756	"HDR through Single Strand Annealing (SSA)";"Processing of DNA double-strand break ends";"Activation of ATR in response to replication stress";"Presynaptic phase of homologous DNA pairing and strand exchange";"G2/M DNA damage checkpoint";"Regulation of TP53 Activity through Phosphorylation"
XP_046414353.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046416532.1	1	Reactome: R-HSA-163765	"ChREBP activates metabolic gene expression"
XP_046419844.1	3	KEGG: 00730+3.1.3.2;KEGG: 00740+3.1.3.2;MetaCyc: PWY-6348	"Thiamine metabolism";"Riboflavin metabolism";"Phosphate acquisition"
XP_046427153.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_046429048.1	13	Reactome: R-HSA-5689877;Reactome: R-HSA-5689896;Reactome: R-HSA-6798695;Reactome: R-HSA-3371511;Reactome: R-HSA-8876725;Reactome: R-HSA-532668;Reactome: R-HSA-8866654;Reactome: R-HSA-9646399;Reactome: R-HSA-382556;Reactome: R-HSA-5678895;Reactome: R-HSA-5362768;Reactome: R-HSA-110320;Reactome: R-HSA-5358346	"Josephin domain DUBs";"Ovarian tumor domain proteases";"Neutrophil degranulation";"HSF1 activation";"Protein methylation";"N-glycan trimming in the ER and Calnexin/Calreticulin cycle";"E3 ubiquitin ligases ubiquitinate target proteins";"Aggrephagy";"ABC-family proteins mediated transport";"Defective CFTR causes cystic fibrosis";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Translesion Synthesis by POLH";"Hedgehog ligand biogenesis"
XP_046413393.1	7	Reactome: R-HSA-6783310;Reactome: R-HSA-6804756;Reactome: R-HSA-69473;Reactome: R-HSA-5685938;Reactome: R-HSA-5693616;Reactome: R-HSA-176187;Reactome: R-HSA-5693607	"Fanconi Anemia Pathway";"Regulation of TP53 Activity through Phosphorylation";"G2/M DNA damage checkpoint";"HDR through Single Strand Annealing (SSA)";"Presynaptic phase of homologous DNA pairing and strand exchange";"Activation of ATR in response to replication stress";"Processing of DNA double-strand break ends"
XP_046415993.1	4	KEGG: 00270+5.3.1.23;Reactome: R-HSA-1237112;MetaCyc: PWY-4361;MetaCyc: PWY-7174	"Cysteine and methionine metabolism";"Methionine salvage pathway";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation II"
XP_046436430.1	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286	"Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation"
XP_046426257.1	3	MetaCyc: PWY-7803;MetaCyc: PWY-6689;Reactome: R-HSA-6784531	"Trna splicing II";"Trna splicing I";"tRNA processing in the nucleus"
XP_046421514.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046411713.1	6	Reactome: R-HSA-2500257;Reactome: R-HSA-5663220;Reactome: R-HSA-2467813;Reactome: R-HSA-68877;Reactome: R-HSA-141444;Reactome: R-HSA-9648025	"Resolution of Sister Chromatid Cohesion";"RHO GTPases Activate Formins";"Separation of Sister Chromatids";"Mitotic Prometaphase";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"EML4 and NUDC in mitotic spindle formation"
XP_046418543.1	4	Reactome: R-HSA-8963889;Reactome: R-HSA-1655829;Reactome: R-HSA-8874211;Reactome: R-HSA-381033	"Assembly of active LPL and LIPC lipase complexes";"Regulation of cholesterol biosynthesis by SREBP (SREBF)";"CREB3 factors activate genes";"ATF6 (ATF6-alpha) activates chaperones"
XP_046416567.1	1	Reactome: R-HSA-420499	"Class C/3 (Metabotropic glutamate/pheromone receptors)"
XP_046423593.1	6	Reactome: R-HSA-1855183;MetaCyc: PWY-6362;MetaCyc: PWY-6364;MetaCyc: PWY-6363;KEGG: 04070+3.1.3.56;KEGG: 00562+3.1.3.56	"Synthesis of IP2, IP, and Ins in the cytosol";"1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)";"D-myo-inositol (1,3,4)-trisphosphate biosynthesis";"D-myo-inositol (1,4,5)-trisphosphate degradation";"Phosphatidylinositol signaling system";"Inositol phosphate metabolism"
XP_046434253.1	1	Reactome: R-HSA-5662702	"Melanin biosynthesis"
XP_046421377.1	2	Reactome: R-HSA-6783310;MetaCyc: PWY-7511	"Fanconi Anemia Pathway";"Protein ubiquitination"
XP_046424943.1	3	Reactome: R-HSA-2408522;KEGG: 00970+6.1.1.20;Reactome: R-HSA-379716	"Selenoamino acid metabolism";"Aminoacyl-tRNA biosynthesis";"Cytosolic tRNA aminoacylation"
XP_046414296.1	6	Reactome: R-HSA-2500257;Reactome: R-HSA-5663220;Reactome: R-HSA-141444;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813;Reactome: R-HSA-68877	"Resolution of Sister Chromatid Cohesion";"RHO GTPases Activate Formins";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids";"Mitotic Prometaphase"
XP_046431389.1	3	Reactome: R-HSA-6785470;Reactome: R-HSA-8868766;Reactome: R-HSA-6787450	"tRNA processing in the mitochondrion";"rRNA processing in the mitochondrion";"tRNA modification in the mitochondrion"
XP_046413293.1	4	Reactome: R-HSA-418594;Reactome: R-HSA-5689880;Reactome: R-HSA-201681;Reactome: R-HSA-4641257	"G alpha (i) signalling events";"Ub-specific processing proteases";"TCF dependent signaling in response to WNT";"Degradation of AXIN"
XP_046416531.1	1	Reactome: R-HSA-163765	"ChREBP activates metabolic gene expression"
XP_046411715.1	57	Reactome: R-HSA-5362768;Reactome: R-HSA-5676590;Reactome: R-HSA-9604323;Reactome: R-HSA-69017;Reactome: R-HSA-5358346;Reactome: R-HSA-69601;Reactome: R-HSA-195253;Reactome: R-HSA-174178;Reactome: R-HSA-2871837;Reactome: R-HSA-1169091;Reactome: R-HSA-68949;Reactome: R-HSA-382556;Reactome: R-HSA-4641258;Reactome: R-HSA-211733;Reactome: R-HSA-5632684;Reactome: R-HSA-450408;Reactome: R-HSA-5610780;Reactome: R-HSA-1236974;Reactome: R-HSA-350562;Reactome: R-HSA-9010553;Reactome: R-HSA-8941858;Reactome: R-HSA-5668541;Reactome: R-HSA-180534;Reactome: R-HSA-187577;Reactome: R-HSA-5607764;Reactome: R-HSA-68827;Reactome: R-HSA-5689603;Reactome: R-HSA-5610783;Reactome: R-HSA-8852276;Reactome: R-HSA-69481;Reactome: R-HSA-1234176;Reactome: R-HSA-8948751;Reactome: R-HSA-9020702;Reactome: R-HSA-8854050;Reactome: R-HSA-5687128;Reactome: R-HSA-174113;Reactome: R-HSA-8939902;Reactome: R-HSA-174184;Reactome: R-HSA-174154;Reactome: R-HSA-2467813;Reactome: R-HSA-983168;Reactome: R-HSA-5658442;Reactome: R-HSA-5607761;Reactome: R-HSA-6798695;Reactome: R-HSA-5610785;Reactome: R-HSA-5678895;Reactome: R-HSA-180585;Reactome: R-HSA-8939236;Reactome: R-HSA-349425;Reactome: R-HSA-8951664;Reactome: R-HSA-174084;Reactome: R-HSA-5689880;Reactome: R-HSA-202424;Reactome: R-HSA-75815;Reactome: R-HSA-4608870;Reactome: R-HSA-4641257;Reactome: R-HSA-1236978	"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"NIK-->noncanonical NF-kB signaling";"Negative regulation of NOTCH4 signaling";"CDK-mediated phosphorylation and removal of Cdc6";"Hedgehog ligand biogenesis";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Degradation of beta-catenin by the destruction complex";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"FCERI mediated NF-kB activation";"Activation of NF-kappaB in B cells";"Orc1 removal from chromatin";"ABC-family proteins mediated transport";"Degradation of DVL";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Hedgehog 'on' state";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Degradation of GLI1 by the proteasome";"ER-Phagosome pathway";"Regulation of ornithine decarboxylase (ODC)";"Regulation of expression of SLITs and ROBOs";"Regulation of RUNX3 expression and activity";"TNFR2 non-canonical NF-kB pathway";"Vpu mediated degradation of CD4";"SCF(Skp2)-mediated degradation of p27/p21";"CLEC7A (Dectin-1) signaling";"CDT1 association with the CDC6:ORC:origin complex";"UCH proteinases";"Degradation of GLI2 by the proteasome";"The role of GTSE1 in G2/M progression after G2 checkpoint";"G2/M Checkpoints";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of PTEN stability and activity";"Interleukin-1 signaling";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"MAPK6/MAPK4 signaling";"SCF-beta-TrCP mediated degradation of Emi1";"Regulation of RUNX2 expression and activity";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"APC/C:Cdc20 mediated degradation of Securin";"Separation of Sister Chromatids";"Antigen processing: Ubiquitination & Proteasome degradation";"Regulation of RAS by GAPs";"Dectin-1 mediated noncanonical NF-kB signaling";"Neutrophil degranulation";"GLI3 is processed to GLI3R by the proteasome";"Defective CFTR causes cystic fibrosis";"Vif-mediated degradation of APOBEC3G";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Autodegradation of the E3 ubiquitin ligase COP1";"Neddylation";"Autodegradation of Cdh1 by Cdh1:APC/C";"Ub-specific processing proteases";"Downstream TCR signaling";"Ubiquitin-dependent degradation of Cyclin D";"Asymmetric localization of PCP proteins";"Degradation of AXIN";"Cross-presentation of soluble exogenous antigens (endosomes)"
XP_046417377.1	17	Reactome: R-HSA-975956;Reactome: R-HSA-72702;Reactome: R-HSA-6791226;Reactome: R-HSA-6790901;Reactome: R-HSA-72706;Reactome: R-HSA-2408557;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-72649;Reactome: R-HSA-72764;Reactome: R-HSA-156902;Reactome: R-HSA-975957;Reactome: R-HSA-1799339;Reactome: R-HSA-72695;Reactome: R-HSA-192823;Reactome: R-HSA-72689	"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Ribosomal scanning and start codon recognition";"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Selenocysteine synthesis";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Translation initiation complex formation";"Eukaryotic Translation Termination";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"Formation of the ternary complex, and subsequently, the 43S complex";"Viral mRNA Translation";"Formation of a pool of free 40S subunits"
XP_046432997.1	13	Reactome: R-HSA-72706;Reactome: R-HSA-2408557;Reactome: R-HSA-1799339;Reactome: R-HSA-9633012;Reactome: R-HSA-72689;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-192823;Reactome: R-HSA-156902;Reactome: R-HSA-975956;Reactome: R-HSA-72764;Reactome: R-HSA-975957;Reactome: R-HSA-6791226	"GTP hydrolysis and joining of the 60S ribosomal subunit";"Selenocysteine synthesis";"SRP-dependent cotranslational protein targeting to membrane";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Formation of a pool of free 40S subunits";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Viral mRNA Translation";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046418910.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_046410641.1	1	Reactome: R-HSA-8949664	"Processing of SMDT1"
XP_046435780.1	1	Reactome: R-HSA-390651	"Dopamine receptors"
XP_046431421.1	3	Reactome: R-HSA-445355;KEGG: 00230+4.6.1.2;Reactome: R-HSA-392154	"Smooth Muscle Contraction";"Purine metabolism";"Nitric oxide stimulates guanylate cyclase"
XP_046421221.1	2	Reactome: R-HSA-1483191;Reactome: R-HSA-425366	"Synthesis of PC";"Transport of bile salts and organic acids, metal ions and amine compounds"
XP_046426473.1	2	Reactome: R-HSA-5689880;MetaCyc: PWY-7511	"Ub-specific processing proteases";"Protein ubiquitination"
XP_046428027.1	2	Reactome: R-HSA-6807505;Reactome: R-HSA-191859	"RNA polymerase II transcribes snRNA genes";"snRNP Assembly"
XP_046434504.1	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
XP_046413806.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_046422746.1	4	Reactome: R-HSA-947581;MetaCyc: PWY-6823;KEGG: 00790+2.8.1.12;MetaCyc: PWY-7887	"Molybdenum cofactor biosynthesis";"Molybdenum cofactor biosynthesis";"Folate biosynthesis";"Protein SAMPylation and SAMP-mediated thiolation"
XP_046410500.1	2	Reactome: R-HSA-5682910;Reactome: R-HSA-5250971	"LGI-ADAM interactions";"Toxicity of botulinum toxin type C (BoNT/C)"
XP_046417835.1	3	Reactome: R-HSA-1445148;Reactome: R-HSA-5620916;Reactome: R-HSA-264876	"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"VxPx cargo-targeting to cilium";"Insulin processing"
XP_046423158.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046418773.1	3	Reactome: R-HSA-445355;KEGG: 00230+4.6.1.2;Reactome: R-HSA-392154	"Smooth Muscle Contraction";"Purine metabolism";"Nitric oxide stimulates guanylate cyclase"
XP_046434946.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046431326.1	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
XP_046427490.1	2	Reactome: R-HSA-5576893;Reactome: R-HSA-5576892	"Phase 2 - plateau phase";"Phase 0 - rapid depolarisation"
XP_046421013.1	6	MetaCyc: PWY-7782;MetaCyc: PWY-5884;KEGG: 00073+1.2.1.84;MetaCyc: PWY-7656;Reactome: R-HSA-9640463;MetaCyc: PWY-6733	"Plasmalogen biosynthesis";"Wax esters biosynthesis I";"Cutin, suberine and wax biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Wax biosynthesis";"Sporopollenin precursors biosynthesis"
XP_046434971.1	3	Reactome: R-HSA-8876198;Reactome: R-HSA-6811440;Reactome: R-HSA-6811438	"RAB GEFs exchange GTP for GDP on RABs";"Retrograde transport at the Trans-Golgi-Network";"Intra-Golgi traffic"
XP_046417210.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_046435707.1	2	Reactome: R-HSA-2142753;KEGG: 00970+6.3.5.7	"Arachidonic acid metabolism";"Aminoacyl-tRNA biosynthesis"
XP_046430058.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_046414113.1	1	Reactome: R-HSA-5250924	"B-WICH complex positively regulates rRNA expression"
XP_046416728.1	6	Reactome: R-HSA-8951430;Reactome: R-HSA-4641265;Reactome: R-HSA-201722;Reactome: R-HSA-3769402;Reactome: R-HSA-4411364;Reactome: R-HSA-4086398	"RUNX3 regulates WNT signaling";"Repression of WNT target genes";"Formation of the beta-catenin:TCF transactivating complex";"Deactivation of the beta-catenin transactivating complex";"Binding of TCF/LEF:CTNNB1 to target gene promoters";"Ca2+ pathway"
XP_046422260.1	2	MetaCyc: PWY-6829;Reactome: R-HSA-6782315	"Trna methylation (yeast)";"tRNA modification in the nucleus and cytosol"
XP_046420050.1	1	Reactome: R-HSA-3214842	"HDMs demethylate histones"
XP_046411427.1	9	Reactome: R-HSA-73779;Reactome: R-HSA-674695;Reactome: R-HSA-73776;Reactome: R-HSA-6804756;Reactome: R-HSA-167161;Reactome: R-HSA-167172;Reactome: R-HSA-167162;Reactome: R-HSA-76042;Reactome: R-HSA-75953	"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Promoter Escape";"Regulation of TP53 Activity through Phosphorylation";"HIV Transcription Initiation";"Transcription of the HIV genome";"RNA Polymerase II HIV Promoter Escape";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II Transcription Initiation"
XP_046428753.1	5	Reactome: R-HSA-936964;Reactome: R-HSA-166166;Reactome: R-HSA-937072;Reactome: R-HSA-168164;Reactome: R-HSA-937041	"Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon";"MyD88-independent TLR4 cascade";"TRAF6-mediated induction of TAK1 complex within TLR4 complex";"Toll Like Receptor 3 (TLR3) Cascade";"IKK complex recruitment mediated by RIP1"
XP_046423322.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046417202.1	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
XP_046411227.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046423829.1	3	Reactome: R-HSA-2142691;MetaCyc: PWY-7533;Reactome: R-HSA-5423646	"Synthesis of Leukotrienes (LT) and Eoxins (EX)";"Gliotoxin biosynthesis";"Aflatoxin activation and detoxification"
XP_046410986.1	6	Reactome: R-HSA-3000171;Reactome: R-HSA-1650814;Reactome: R-HSA-8874081;Reactome: R-HSA-1442490;Reactome: R-HSA-2022090;Reactome: R-HSA-8948216	"Non-integrin membrane-ECM interactions";"Collagen biosynthesis and modifying enzymes";"MET activates PTK2 signaling";"Collagen degradation";"Assembly of collagen fibrils and other multimeric structures";"Collagen chain trimerization"
XP_046415112.1	5	Reactome: R-HSA-73762;Reactome: R-HSA-73772;Reactome: R-HSA-5250924;Reactome: R-HSA-73863;Reactome: R-HSA-427413	"RNA Polymerase I Transcription Initiation";"RNA Polymerase I Promoter Escape";"B-WICH complex positively regulates rRNA expression";"RNA Polymerase I Transcription Termination";"NoRC negatively regulates rRNA expression"
XP_046410993.1	5	Reactome: R-HSA-1912399;Reactome: R-HSA-5083630;Reactome: R-HSA-1912420;Reactome: R-HSA-1912408;Reactome: R-HSA-350054	"Pre-NOTCH Processing in the Endoplasmic Reticulum";"Defective LFNG causes SCDO3";"Pre-NOTCH Processing in Golgi";"Pre-NOTCH Transcription and Translation";"Notch-HLH transcription pathway"
XP_046410802.1	3	Reactome: R-HSA-73856;Reactome: R-HSA-159236;Reactome: R-HSA-72187	"RNA Polymerase II Transcription Termination";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"mRNA 3'-end processing"
XP_046424873.1	12	Reactome: R-HSA-194840;Reactome: R-HSA-1839117;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04150+2.7.11.1;Reactome: R-HSA-5655302;Reactome: R-HSA-416482;KEGG: 04151+2.7.11.1;KEGG: 05163+2.7.11.1;Reactome: R-HSA-193648;KEGG: 04926+2.7.11.1	"Rho GTPase cycle";"Signaling by cytosolic FGFR1 fusion mutants";"Thermogenesis";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"mTOR signaling pathway";"Signaling by FGFR1 in disease";"G alpha (12/13) signalling events";"PI3K-Akt signaling pathway";"Human cytomegalovirus infection";"NRAGE signals death through JNK";"Relaxin signaling pathway"
XP_046423334.1	2	Reactome: R-HSA-180024;KEGG: 00230+3.1.4.53	"DARPP-32 events";"Purine metabolism"
XP_046419840.1	3	MetaCyc: PWY-6348;KEGG: 00740+3.1.3.2;KEGG: 00730+3.1.3.2	"Phosphate acquisition";"Riboflavin metabolism";"Thiamine metabolism"
XP_046417748.1	1	Reactome: R-HSA-201451	"Signaling by BMP"
XP_046425987.1	1	Reactome: R-HSA-611105	"Respiratory electron transport"
XP_046420088.1	2	Reactome: R-HSA-8856828;Reactome: R-HSA-8856825	"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis"
XP_046419585.1	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
XP_046422895.1	1	Reactome: R-HSA-6811438	"Intra-Golgi traffic"
XP_046415230.1	4	Reactome: R-HSA-2470946;Reactome: R-HSA-2500257;Reactome: R-HSA-2468052;Reactome: R-HSA-2467813	"Cohesin Loading onto Chromatin";"Resolution of Sister Chromatid Cohesion";"Establishment of Sister Chromatid Cohesion";"Separation of Sister Chromatids"
XP_046415828.1	9	Reactome: R-HSA-176187;Reactome: R-HSA-68827;Reactome: R-HSA-68949;Reactome: R-HSA-68962;Reactome: R-HSA-69205;Reactome: R-HSA-68867;Reactome: R-HSA-113507;Reactome: R-HSA-68689;Reactome: R-HSA-68616	"Activation of ATR in response to replication stress";"CDT1 association with the CDC6:ORC:origin complex";"Orc1 removal from chromatin";"Activation of the pre-replicative complex";"G1/S-Specific Transcription";"Assembly of the pre-replicative complex";"E2F-enabled inhibition of pre-replication complex formation";"CDC6 association with the ORC:origin complex";"Assembly of the ORC complex at the origin of replication"
XP_046427418.1	9	KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;Reactome: R-HSA-6782315;KEGG: 05163+2.7.11.1;Reactome: R-HSA-6804756;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1	"mTOR signaling pathway";"PI3K-Akt signaling pathway";"tRNA modification in the nucleus and cytosol";"Human cytomegalovirus infection";"Regulation of TP53 Activity through Phosphorylation";"Relaxin signaling pathway";"Thermogenesis";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection"
XP_046434686.1	3	Reactome: R-HSA-74217;KEGG: 00230+3.5.4.6;MetaCyc: PWY-6596	"Purine salvage";"Purine metabolism";"Adenosine nucleotides degradation I"
XP_046415664.1	1	Reactome: R-HSA-9609523	"Insertion of tail-anchored proteins into the endoplasmic reticulum membrane"
XP_046426622.1	25	Reactome: R-HSA-2132295;Reactome: R-HSA-5617833;Reactome: R-HSA-68877;Reactome: R-HSA-190840;Reactome: R-HSA-8852276;Reactome: R-HSA-190861;Reactome: R-HSA-9646399;Reactome: R-HSA-6811436;Reactome: R-HSA-8955332;Reactome: R-HSA-9609736;Reactome: R-HSA-5663220;Reactome: R-HSA-437239;Reactome: R-HSA-380270;Reactome: R-HSA-3371497;Reactome: R-HSA-6811434;Reactome: R-HSA-9609690;Reactome: R-HSA-2467813;Reactome: R-HSA-9648025;Reactome: R-HSA-380320;Reactome: R-HSA-1445148;Reactome: R-HSA-983189;Reactome: R-HSA-2500257;Reactome: R-HSA-9619483;Reactome: R-HSA-6807878;Reactome: R-HSA-5626467	"MHC class II antigen presentation";"Cilium Assembly";"Mitotic Prometaphase";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Gap junction assembly";"Aggrephagy";"COPI-independent Golgi-to-ER retrograde traffic";"Carboxyterminal post-translational modifications of tubulin";"Assembly and cell surface presentation of NMDA receptors";"RHO GTPases Activate Formins";"Recycling pathway of L1";"Recruitment of mitotic centrosome proteins and complexes";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-dependent Golgi-to-ER retrograde traffic";"HCMV Early Events";"Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation";"Recruitment of NuMA to mitotic centrosomes";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Kinesins";"Resolution of Sister Chromatid Cohesion";"Activation of AMPK downstream of NMDARs";"COPI-mediated anterograde transport";"RHO GTPases activate IQGAPs"
XP_046419461.1	1	Reactome: R-HSA-6811438	"Intra-Golgi traffic"
XP_046433244.1	3	Reactome: R-HSA-2024096;Reactome: R-HSA-6798695;Reactome: R-HSA-2206291	"HS-GAG degradation";"Neutrophil degranulation";"MPS IIIC - Sanfilippo syndrome C"
XP_046422269.1	1	Reactome: R-HSA-432722	"Golgi Associated Vesicle Biogenesis"
XP_046415426.1	6	Reactome: R-HSA-264642;Reactome: R-HSA-181430;Reactome: R-HSA-181429;Reactome: R-HSA-210500;Reactome: R-HSA-212676;Reactome: R-HSA-388844	"Acetylcholine Neurotransmitter Release Cycle";"Norepinephrine Neurotransmitter Release Cycle";"Serotonin Neurotransmitter Release Cycle";"Glutamate Neurotransmitter Release Cycle";"Dopamine Neurotransmitter Release Cycle";"Receptor-type tyrosine-protein phosphatases"
XP_046434813.1	8	KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04714+2.7.11.1;Reactome: R-HSA-9633012	"Relaxin signaling pathway";"Human cytomegalovirus infection";"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Thermogenesis";"Response of EIF2AK4 (GCN2) to amino acid deficiency"
XP_046423794.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_046422084.1	3	Reactome: R-HSA-416482;Reactome: R-HSA-194840;Reactome: R-HSA-193648	"G alpha (12/13) signalling events";"Rho GTPase cycle";"NRAGE signals death through JNK"
XP_046410787.1	6	Reactome: R-HSA-6791226;Reactome: R-HSA-450385;Reactome: R-HSA-429958;Reactome: R-HSA-380994;Reactome: R-HSA-450604;Reactome: R-HSA-450513	"Major pathway of rRNA processing in the nucleolus and cytosol";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"mRNA decay by 3' to 5' exoribonuclease";"ATF4 activates genes in response to endoplasmic reticulum stress";"KSRP (KHSRP) binds and destabilizes mRNA";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA"
XP_046420956.1	3	KEGG: 00051+1.1.1.271;Reactome: R-HSA-6787639;KEGG: 00520+1.1.1.271	"Fructose and mannose metabolism";"GDP-fucose biosynthesis";"Amino sugar and nucleotide sugar metabolism"
XP_046433914.1	1	Reactome: R-HSA-9633012	"Response of EIF2AK4 (GCN2) to amino acid deficiency"
XP_046426371.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046428212.1	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
XP_046435458.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046416110.1	5	Reactome: R-HSA-5693579;Reactome: R-HSA-5693616;Reactome: R-HSA-5693554;Reactome: R-HSA-5685942;Reactome: R-HSA-5693568	"Homologous DNA Pairing and Strand Exchange";"Presynaptic phase of homologous DNA pairing and strand exchange";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"HDR through Homologous Recombination (HRR)";"Resolution of D-loop Structures through Holliday Junction Intermediates"
XP_046428706.1	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_046422855.1	1	Reactome: R-HSA-426048	"Arachidonate production from DAG"
XP_046413805.1	6	Reactome: R-HSA-68867;Reactome: R-HSA-176974;Reactome: R-HSA-176187;Reactome: R-HSA-68962;Reactome: R-HSA-68949;Reactome: R-HSA-69052	"Assembly of the pre-replicative complex";"Unwinding of DNA";"Activation of ATR in response to replication stress";"Activation of the pre-replicative complex";"Orc1 removal from chromatin";"Switching of origins to a post-replicative state"
XP_046423252.1	1	Reactome: R-HSA-72165	"mRNA Splicing - Minor Pathway"
XP_046432802.1	1	KEGG: 00480+3.4.11.1	"Glutathione metabolism"
XP_046421108.1	4	MetaCyc: PWY-7382;Reactome: R-HSA-389661;MetaCyc: PWY-6987;KEGG: 00785+2.3.1.181	"Lipoate biosynthesis and incorporation IV (yeast)";"Glyoxylate metabolism and glycine degradation";"Lipoate biosynthesis and incorporation III (Bacillus)";"Lipoic acid metabolism"
XP_046422016.1	1	Reactome: R-HSA-2559584	"Formation of Senescence-Associated Heterochromatin Foci (SAHF)"
XP_046429743.1	4	Reactome: R-HSA-446199;Reactome: R-HSA-4755583;MetaCyc: PWY-6129;KEGG: 00510+2.7.1.108	"Synthesis of Dolichyl-phosphate";"Defective DOLK causes DOLK-CDG (CDG-1m)";"Dolichol and dolichyl phosphate biosynthesis";"N-Glycan biosynthesis"
XP_046416920.1	14	KEGG: 00565+3.1.1.4;Reactome: R-HSA-1482788;MetaCyc: PWY-6803;MetaCyc: PWY-8051;KEGG: 00564+3.1.1.4+3.1.1.5;KEGG: 00592+3.1.1.4;MetaCyc: PWY-7783;KEGG: 00590+3.1.1.4;Reactome: R-HSA-975634;MetaCyc: PWY-7416;MetaCyc: PWY-8053;MetaCyc: PWY-7409;MetaCyc: PWY-7417;KEGG: 00591+3.1.1.4	"Ether lipid metabolism";"Acyl chain remodelling of PC";"Phosphatidylcholine acyl editing";"Anandamide biosynthesis I";"Glycerophospholipid metabolism";"alpha-Linolenic acid metabolism";"Plasmalogen degradation";"Arachidonic acid metabolism";"Retinoid metabolism and transport";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Anandamide biosynthesis II";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Phospholipid remodeling (phosphatidate, yeast)";"Linoleic acid metabolism"
XP_046436691.1	12	Reactome: R-HSA-2500257;Reactome: R-HSA-5663220;Reactome: R-HSA-6807878;Reactome: R-HSA-3371497;Reactome: R-HSA-2132295;Reactome: R-HSA-6811436;Reactome: R-HSA-2467813;Reactome: R-HSA-9646399;Reactome: R-HSA-68877;Reactome: R-HSA-9609690;Reactome: R-HSA-141444;Reactome: R-HSA-9648025	"Resolution of Sister Chromatid Cohesion";"RHO GTPases Activate Formins";"COPI-mediated anterograde transport";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"MHC class II antigen presentation";"COPI-independent Golgi-to-ER retrograde traffic";"Separation of Sister Chromatids";"Aggrephagy";"Mitotic Prometaphase";"HCMV Early Events";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"EML4 and NUDC in mitotic spindle formation"
XP_046419692.1	4	KEGG: 00510+2.4.1.131;Reactome: R-HSA-446193;KEGG: 00513+2.4.1.131;Reactome: R-HSA-4551295	"N-Glycan biosynthesis";"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"Various types of N-glycan biosynthesis";"Defective ALG11 causes ALG11-CDG (CDG-1p)"
XP_046430948.1	1	Reactome: R-HSA-8854691	"Interleukin-20 family signaling"
XP_046422145.1	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
XP_046409766.1	12	Reactome: R-HSA-418885;Reactome: R-HSA-416482;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05163+2.7.11.1;Reactome: R-HSA-416476;Reactome: R-HSA-193648;KEGG: 04926+2.7.11.1;Reactome: R-HSA-194840;KEGG: 04714+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1	"DCC mediated attractive signaling";"G alpha (12/13) signalling events";"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Human cytomegalovirus infection";"G alpha (q) signalling events";"NRAGE signals death through JNK";"Relaxin signaling pathway";"Rho GTPase cycle";"Thermogenesis";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection"
XP_046417762.1	1	Reactome: R-HSA-5662702	"Melanin biosynthesis"
XP_046412852.1	14	Reactome: R-HSA-75876;MetaCyc: PWY-5972;MetaCyc: PWY-7724;MetaCyc: PWY-6433;MetaCyc: PWY-7602;MetaCyc: PWY-6598;MetaCyc: PWY-7036;MetaCyc: PWY-8041;MetaCyc: PWY-7035;MetaCyc: PWY-7725;MetaCyc: PWY-7619;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7601;MetaCyc: PWY-5080	"Synthesis of very long-chain fatty acyl-CoAs";"Stearate biosynthesis I (animals)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Hydroxylated fatty acid biosynthesis (plants)";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Sciadonate biosynthesis";"Very long chain fatty acid biosynthesis II";"Ultra-long-chain fatty acid biosynthesis";"(9Z)-tricosene biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Juniperonate biosynthesis";"Fatty acid elongation";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis I"
XP_046418315.1	1	Reactome: R-HSA-8849932	"Synaptic adhesion-like molecules"
XP_046427906.1	6	MetaCyc: PWY-7039;KEGG: 00561+2.7.1.107;MetaCyc: PWY-7817;KEGG: 00564+2.7.1.107;Reactome: R-HSA-114508;KEGG: 04070+2.7.1.107	"Phosphatidate metabolism, as a signaling molecule";"Glycerolipid metabolism";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Glycerophospholipid metabolism";"Effects of PIP2 hydrolysis";"Phosphatidylinositol signaling system"
XP_046421758.1	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
XP_046420862.1	33	Reactome: R-HSA-3232142;Reactome: R-HSA-2500257;Reactome: R-HSA-3371453;Reactome: R-HSA-4551638;Reactome: R-HSA-9610379;Reactome: R-HSA-9648025;Reactome: R-HSA-1169408;Reactome: R-HSA-3108214;Reactome: R-HSA-159231;Reactome: R-HSA-2467813;Reactome: R-HSA-168271;Reactome: R-HSA-5619107;Reactome: R-HSA-168276;Reactome: R-HSA-191859;Reactome: R-HSA-159230;Reactome: R-HSA-4615885;Reactome: R-HSA-170822;Reactome: R-HSA-180910;Reactome: R-HSA-165054;Reactome: R-HSA-6784531;Reactome: R-HSA-4085377;Reactome: R-HSA-4570464;Reactome: R-HSA-159236;Reactome: R-HSA-141444;Reactome: R-HSA-168325;Reactome: R-HSA-9609690;Reactome: R-HSA-5663220;Reactome: R-HSA-168333;Reactome: R-HSA-159227;Reactome: R-HSA-3301854;Reactome: R-HSA-5578749;Reactome: R-HSA-180746;Reactome: R-HSA-68877	"SUMOylation of ubiquitinylation proteins";"Resolution of Sister Chromatid Cohesion";"Regulation of HSF1-mediated heat shock response";"SUMOylation of chromatin organization proteins";"HCMV Late Events";"EML4 and NUDC in mitotic spindle formation";"ISG15 antiviral mechanism";"SUMOylation of DNA damage response and repair proteins";"Transport of Mature mRNA Derived from an Intronless Transcript";"Separation of Sister Chromatids";"Transport of Ribonucleoproteins into the Host Nucleus";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"NS1 Mediated Effects on Host Pathways";"snRNP Assembly";"Transport of the SLBP Dependant Mature mRNA";"SUMOylation of DNA replication proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Vpr-mediated nuclear import of PICs";"Rev-mediated nuclear export of HIV RNA";"tRNA processing in the nucleus";"SUMOylation of SUMOylation proteins";"SUMOylation of RNA binding proteins";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Viral Messenger RNA Synthesis";"HCMV Early Events";"RHO GTPases Activate Formins";"NEP/NS2 Interacts with the Cellular Export Machinery";"Transport of the SLBP independent Mature mRNA";"Nuclear Pore Complex (NPC) Disassembly";"Transcriptional regulation by small RNAs";"Nuclear import of Rev protein";"Mitotic Prometaphase"
XP_046433348.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046424588.1	7	Reactome: R-HSA-5674400;Reactome: R-HSA-380972;Reactome: R-HSA-198323;Reactome: R-HSA-5628897;Reactome: R-HSA-165181;Reactome: R-HSA-8854214;Reactome: R-HSA-1632852	"Constitutive Signaling by AKT1 E17K in Cancer";"Energy dependent regulation of mTOR by LKB1-AMPK";"AKT phosphorylates targets in the cytosol";"TP53 Regulates Metabolic Genes";"Inhibition of TSC complex formation by PKB";"TBC/RABGAPs";"Macroautophagy"
XP_046436394.1	4	MetaCyc: PWY-7494;MetaCyc: PWY-3722;Reactome: R-HSA-6798163;KEGG: 00260+1.2.1.8+1.1.99.1	"Choline degradation IV";"Glycine betaine biosynthesis II (Gram-positive bacteria)";"Choline catabolism";"Glycine, serine and threonine metabolism"
XP_046423538.1	1	Reactome: R-HSA-2132295	"MHC class II antigen presentation"
XP_046414139.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_046410442.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046417967.1	3	Reactome: R-HSA-8951664;Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"Neddylation";"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046432608.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_046413274.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046421042.1	5	KEGG: 00020+1.2.4.2;Reactome: R-HSA-389661;MetaCyc: PWY-5084;KEGG: 00380+1.2.4.2;KEGG: 00310+1.2.4.2	"Citrate cycle (TCA cycle)";"Glyoxylate metabolism and glycine degradation";"2-oxoglutarate decarboxylation to succinyl-CoA";"Tryptophan metabolism";"Lysine degradation"
XP_046423845.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046412234.1	1	Reactome: R-HSA-8866654	"E3 ubiquitin ligases ubiquitinate target proteins"
XP_046414357.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046434872.1	1	Reactome: R-HSA-1445148	"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
XP_046409420.1	2	Reactome: R-HSA-375276;Reactome: R-HSA-416476	"Peptide ligand-binding receptors";"G alpha (q) signalling events"
XP_046428747.1	5	Reactome: R-HSA-936964;Reactome: R-HSA-937072;Reactome: R-HSA-166166;Reactome: R-HSA-168164;Reactome: R-HSA-937041	"Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon";"TRAF6-mediated induction of TAK1 complex within TLR4 complex";"MyD88-independent TLR4 cascade";"Toll Like Receptor 3 (TLR3) Cascade";"IKK complex recruitment mediated by RIP1"
XP_046411249.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_046422213.1	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
XP_046432112.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_046413330.1	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
XP_046426096.1	1	MetaCyc: PWY-6829	"Trna methylation (yeast)"
XP_046414338.1	2	Reactome: R-HSA-6814122;Reactome: R-HSA-418594	"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"G alpha (i) signalling events"
XP_046424411.1	3	Reactome: R-HSA-450385;Reactome: R-HSA-430039;Reactome: R-HSA-450513	"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"mRNA decay by 5' to 3' exoribonuclease";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA"
XP_046419928.1	8	MetaCyc: PWY-7979;KEGG: 00515+2.4.1.109;Reactome: R-HSA-5083633;MetaCyc: PWY-7921;KEGG: 00514+2.4.1.109;MetaCyc: PWY-7922;Reactome: R-HSA-5083629;Reactome: R-HSA-5173105	"Protein O-mannosylation III (mammals, core M3)";"Mannose type O-glycan biosynthesis";"Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1";"Protein O-mannosylation I (yeast)";"Other types of O-glycan biosynthesis";"Protein O-mannosylation II (mammals, core M1 and core M2)";"Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2";"O-linked glycosylation"
XP_046428729.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_046413521.1	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
XP_046424743.1	1	Reactome: R-HSA-193648	"NRAGE signals death through JNK"
XP_046422669.1	1	Reactome: R-HSA-2393930	"Phosphate bond hydrolysis by NUDT proteins"
XP_046416571.1	1	Reactome: R-HSA-420499	"Class C/3 (Metabotropic glutamate/pheromone receptors)"
XP_046417252.1	1	Reactome: R-HSA-5576886	"Phase 4 - resting membrane potential"
XP_046416861.1	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
XP_046420659.1	1	Reactome: R-HSA-6785631	"ERBB2 Regulates Cell Motility"
XP_046428359.1	2	Reactome: R-HSA-4641265;Reactome: R-HSA-5339700	"Repression of WNT target genes";"TCF7L2 mutants don't bind CTBP"
XP_046433845.1	1	Reactome: R-HSA-1474228	"Degradation of the extracellular matrix"
XP_046429504.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_046414611.1	1	Reactome: R-HSA-525793	"Myogenesis"
XP_046433026.1	10	Reactome: R-HSA-8941856;Reactome: R-HSA-9013695;Reactome: R-HSA-2197563;Reactome: R-HSA-2894862;Reactome: R-HSA-210744;Reactome: R-HSA-1912408;Reactome: R-HSA-2644606;Reactome: R-HSA-9013508;Reactome: R-HSA-2122947;Reactome: R-HSA-350054	"RUNX3 regulates NOTCH signaling";"NOTCH4 Intracellular Domain Regulates Transcription";"NOTCH2 intracellular domain regulates transcription";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"Pre-NOTCH Transcription and Translation";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH3 Intracellular Domain Regulates Transcription";"NOTCH1 Intracellular Domain Regulates Transcription";"Notch-HLH transcription pathway"
XP_046423217.1	1	KEGG: 04660+2.7.10.2	"T cell receptor signaling pathway"
XP_046414678.1	1	Reactome: R-HSA-6803157	"Antimicrobial peptides"
XP_046419892.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046410499.1	2	Reactome: R-HSA-5682910;Reactome: R-HSA-5250971	"LGI-ADAM interactions";"Toxicity of botulinum toxin type C (BoNT/C)"
XP_046429315.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_046422164.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046425108.1	2	Reactome: R-HSA-376176;Reactome: R-HSA-202433	"Signaling by ROBO receptors";"Generation of second messenger molecules"
XP_046433037.1	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
XP_046418148.1	1	Reactome: R-HSA-1445148	"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
XP_046435089.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_046432025.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_046419367.1	1	Reactome: R-HSA-3238698	"WNT ligand biogenesis and trafficking"
XP_046422876.1	1	Reactome: R-HSA-6794361	"Neurexins and neuroligins"
XP_046413472.1	9	Reactome: R-HSA-1368082;Reactome: R-HSA-400253;Reactome: R-HSA-400206;Reactome: R-HSA-1989781;Reactome: R-HSA-2426168;Reactome: R-HSA-2151201;Reactome: R-HSA-1368108;Reactome: R-HSA-5617472;Reactome: R-HSA-381340	"RORA activates gene expression";"Circadian Clock";"Regulation of lipid metabolism by PPARalpha";"PPARA activates gene expression";"Activation of gene expression by SREBF (SREBP)";"Transcriptional activation of mitochondrial biogenesis";"BMAL1:CLOCK,NPAS2 activates circadian gene expression";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Transcriptional regulation of white adipocyte differentiation"
XP_046409806.1	1	Reactome: R-HSA-425381	"Bicarbonate transporters"
XP_046411081.1	3	Reactome: R-HSA-1989781;Reactome: R-HSA-381340;Reactome: R-HSA-9018519	"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation";"Estrogen-dependent gene expression"
XP_046427468.1	3	Reactome: R-HSA-8963693;KEGG: 00460+3.5.1.1;KEGG: 00250+3.5.1.1	"Aspartate and asparagine metabolism";"Cyanoamino acid metabolism";"Alanine, aspartate and glutamate metabolism"
XP_046420818.1	5	Reactome: R-HSA-9648895;Reactome: R-HSA-380994;KEGG: 00250+6.3.5.4;Reactome: R-HSA-9633012;Reactome: R-HSA-8963693	"Response of EIF2AK1 (HRI) to heme deficiency";"ATF4 activates genes in response to endoplasmic reticulum stress";"Alanine, aspartate and glutamate metabolism";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Aspartate and asparagine metabolism"
XP_046413904.1	3	KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16	"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
XP_046434154.1	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
XP_046410743.1	4	Reactome: R-HSA-5576893;Reactome: R-HSA-5576892;Reactome: R-HSA-419037;Reactome: R-HSA-112308	"Phase 2 - plateau phase";"Phase 0 - rapid depolarisation";"NCAM1 interactions";"Presynaptic depolarization and calcium channel opening"
XP_046420626.1	1	Reactome: R-HSA-1799339	"SRP-dependent cotranslational protein targeting to membrane"
XP_046416074.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046422000.1	2	Reactome: R-HSA-1296052;Reactome: R-HSA-418457	"Ca2+ activated K+ channels";"cGMP effects"
XP_046429053.1	1	Reactome: R-HSA-1632852	"Macroautophagy"
XP_046432980.1	1	Reactome: R-HSA-70221	"Glycogen breakdown (glycogenolysis)"
XP_046422695.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
XP_046435752.1	7	Reactome: R-HSA-70268;KEGG: 00010+1.2.4.1;KEGG: 00620+1.2.4.1;KEGG: 00020+1.2.4.1;Reactome: R-HSA-5362517;Reactome: R-HSA-389661;Reactome: R-HSA-204174	"Pyruvate metabolism";"Glycolysis / Gluconeogenesis";"Pyruvate metabolism";"Citrate cycle (TCA cycle)";"Signaling by Retinoic Acid";"Glyoxylate metabolism and glycine degradation";"Regulation of pyruvate dehydrogenase (PDH) complex"
XP_046428374.1	2	MetaCyc: PWY-7221;KEGG: 00230+2.7.4.8	"Guanosine ribonucleotides de novo biosynthesis";"Purine metabolism"
XP_046429149.1	5	Reactome: R-HSA-1989781;Reactome: R-HSA-211976;Reactome: R-HSA-211981;Reactome: R-HSA-8937144;Reactome: R-HSA-211945	"PPARA activates gene expression";"Endogenous sterols";"Xenobiotics";"Aryl hydrocarbon receptor signalling";"Phase I - Functionalization of compounds"
XP_046429010.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_046410118.1	2	KEGG: 00051+2.7.1.105+3.1.3.46;Reactome: R-HSA-9634600	"Fructose and mannose metabolism";"Regulation of glycolysis by fructose 2,6-bisphosphate metabolism"
XP_046412503.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_046414172.1	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
XP_046424428.1	1	Reactome: R-HSA-2467813	"Separation of Sister Chromatids"
XP_046410145.1	2	KEGG: 00051+2.7.1.105+3.1.3.46;Reactome: R-HSA-9634600	"Fructose and mannose metabolism";"Regulation of glycolysis by fructose 2,6-bisphosphate metabolism"
XP_046419283.1	2	Reactome: R-HSA-8963888;Reactome: R-HSA-8866423	"Chylomicron assembly";"VLDL assembly"
XP_046414364.1	17	Reactome: R-HSA-176409;Reactome: R-HSA-8853884;Reactome: R-HSA-8951664;Reactome: R-HSA-174084;Reactome: R-HSA-176412;Reactome: R-HSA-179409;Reactome: R-HSA-174048;Reactome: R-HSA-141430;Reactome: R-HSA-983168;Reactome: R-HSA-2559582;Reactome: R-HSA-174178;Reactome: R-HSA-2467813;Reactome: R-HSA-174154;Reactome: R-HSA-69017;Reactome: R-HSA-174184;Reactome: R-HSA-176408;Reactome: R-HSA-176407	"APC/C:Cdc20 mediated degradation of mitotic proteins";"Transcriptional Regulation by VENTX";"Neddylation";"Autodegradation of Cdh1 by Cdh1:APC/C";"Phosphorylation of the APC/C";"APC-Cdc20 mediated degradation of Nek2A";"APC/C:Cdc20 mediated degradation of Cyclin B";"Inactivation of APC/C via direct inhibition of the APC/C complex";"Antigen processing: Ubiquitination & Proteasome degradation";"Senescence-Associated Secretory Phenotype (SASP)";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Separation of Sister Chromatids";"APC/C:Cdc20 mediated degradation of Securin";"CDK-mediated phosphorylation and removal of Cdc6";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Regulation of APC/C activators between G1/S and early anaphase";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase"
XP_046424042.1	1	Reactome: R-HSA-435368	"Zinc efflux and compartmentalization by the SLC30 family"
XP_046425784.1	2	MetaCyc: PWY-6854;Reactome: R-HSA-3299685	"Ethylene biosynthesis III (microbes)";"Detoxification of Reactive Oxygen Species"
XP_046434045.1	1	Reactome: R-HSA-8953750	"Transcriptional Regulation by E2F6"
XP_046416578.1	3	Reactome: R-HSA-5368286;KEGG: 00670+2.1.2.9;KEGG: 00970+2.1.2.9	"Mitochondrial translation initiation";"One carbon pool by folate";"Aminoacyl-tRNA biosynthesis"
XP_046411294.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_046414417.1	2	Reactome: R-HSA-983168;Reactome: R-HSA-8951664	"Antigen processing: Ubiquitination & Proteasome degradation";"Neddylation"
XP_046417830.1	4	Reactome: R-HSA-196757;KEGG: 00970+2.1.2.9;KEGG: 00670+2.1.2.9;KEGG: 00670+1.5.1.6	"Metabolism of folate and pterines";"Aminoacyl-tRNA biosynthesis";"One carbon pool by folate";"One carbon pool by folate"
XP_046409323.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_046412176.1	4	Reactome: R-HSA-73614;KEGG: 00983+2.7.1.48;MetaCyc: PWY-7193;KEGG: 00240+2.7.1.48	"Pyrimidine salvage";"Drug metabolism - other enzymes";"Pyrimidine ribonucleosides salvage I";"Pyrimidine metabolism"
XP_046413811.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046421171.1	2	Reactome: R-HSA-3299685;KEGG: 00480+1.11.1.15	"Detoxification of Reactive Oxygen Species";"Glutathione metabolism"
XP_046430678.1	2	Reactome: R-HSA-5685938;Reactome: R-HSA-3108214	"HDR through Single Strand Annealing (SSA)";"SUMOylation of DNA damage response and repair proteins"
XP_046416510.1	6	Reactome: R-HSA-73817;KEGG: 00230+4.1.1.21;KEGG: 00230+6.3.2.6;MetaCyc: PWY-6124;MetaCyc: PWY-7234;MetaCyc: PWY-6123	"Purine ribonucleoside monophosphate biosynthesis";"Purine metabolism";"Purine metabolism";"Inosine-5'-phosphate biosynthesis II";"Inosine-5'-phosphate biosynthesis III";"Inosine-5'-phosphate biosynthesis I"
XP_046421627.1	3	KEGG: 04070+2.7.4.24+2.7.4.21;Reactome: R-HSA-1855167;MetaCyc: PWY-6369	"Phosphatidylinositol signaling system";"Synthesis of pyrophosphates in the cytosol";"Inositol diphosphates biosynthesis"
XP_046426254.1	1	Reactome: R-HSA-69273	"Cyclin A/B1/B2 associated events during G2/M transition"
XP_046428982.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_046421080.1	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
XP_046436252.1	2	Reactome: R-HSA-8949664;Reactome: R-HSA-8949215	"Processing of SMDT1";"Mitochondrial calcium ion transport"
XP_046423658.1	1	Reactome: R-HSA-419037	"NCAM1 interactions"
XP_046436031.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
XP_046432084.1	7	KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1	"Thermogenesis";"Human cytomegalovirus infection";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Relaxin signaling pathway";"mTOR signaling pathway";"PI3K-Akt signaling pathway"
XP_046413983.1	8	Reactome: R-HSA-2028269;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1	"Signaling by Hippo";"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Relaxin signaling pathway";"Human cytomegalovirus infection";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Thermogenesis"
XP_046427422.1	9	KEGG: 04714+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04150+2.7.11.1;Reactome: R-HSA-6782315;KEGG: 04151+2.7.11.1;KEGG: 05163+2.7.11.1;Reactome: R-HSA-6804756;KEGG: 04926+2.7.11.1	"Thermogenesis";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"mTOR signaling pathway";"tRNA modification in the nucleus and cytosol";"PI3K-Akt signaling pathway";"Human cytomegalovirus infection";"Regulation of TP53 Activity through Phosphorylation";"Relaxin signaling pathway"
XP_046413336.1	5	KEGG: 00052+2.7.1.6;KEGG: 00520+2.7.1.6;MetaCyc: PWY-6527;MetaCyc: PWY-3821;MetaCyc: PWY-6317	"Galactose metabolism";"Amino sugar and nucleotide sugar metabolism";"Stachyose degradation";"D-galactose detoxification";"D-galactose degradation I (Leloir pathway)"
XP_046425794.1	2	Reactome: R-HSA-983168;Reactome: R-HSA-110320	"Antigen processing: Ubiquitination & Proteasome degradation";"Translesion Synthesis by POLH"
XP_046426584.1	2	MetaCyc: PWY-5041;KEGG: 00270+3.3.1.1	"S-adenosyl-L-methionine cycle II";"Cysteine and methionine metabolism"
XP_046421384.1	1	Reactome: R-HSA-1237044	"Erythrocytes take up carbon dioxide and release oxygen"
XP_046430094.1	3	KEGG: 00790+2.10.1.1;MetaCyc: PWY-6823;Reactome: R-HSA-947581	"Folate biosynthesis";"Molybdenum cofactor biosynthesis";"Molybdenum cofactor biosynthesis"
XP_046409779.1	2	Reactome: R-HSA-429947;Reactome: R-HSA-6804115	"Deadenylation of mRNA";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"
XP_046435456.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046410136.1	2	Reactome: R-HSA-9634600;KEGG: 00051+2.7.1.105+3.1.3.46	"Regulation of glycolysis by fructose 2,6-bisphosphate metabolism";"Fructose and mannose metabolism"
XP_046409624.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_046414785.1	14	KEGG: 00670+2.1.2.1;MetaCyc: PWY-3661-1;KEGG: 00680+2.1.2.1;MetaCyc: PWY-181;Reactome: R-HSA-196757;KEGG: 00630+2.1.2.1;MetaCyc: PWY-1622;MetaCyc: PWY-2201;MetaCyc: PWY-3841;MetaCyc: PWY-3661;KEGG: 00260+2.1.2.1;MetaCyc: PWY-2161;MetaCyc: PWY-5497;KEGG: 00460+2.1.2.1	"One carbon pool by folate";"Glycine betaine degradation II (mammalian)";"Methane metabolism";"Photorespiration ";"Metabolism of folate and pterines";"Glyoxylate and dicarboxylate metabolism";"Formaldehyde assimilation I (serine pathway)";"Folate transformations I";"Folate transformations II (plants)";"Glycine betaine degradation I";"Glycine, serine and threonine metabolism";"Folate polyglutamylation";"Purine nucleobases degradation II (anaerobic)";"Cyanoamino acid metabolism"
XP_046410751.1	10	Reactome: R-HSA-9636383;Reactome: R-HSA-182971;Reactome: R-HSA-6807004;Reactome: R-HSA-917729;Reactome: R-HSA-8856828;Reactome: R-HSA-9635644;Reactome: R-HSA-8856825;Reactome: R-HSA-432720;Reactome: R-HSA-5689880;Reactome: R-HSA-8875360	"Prevention of phagosomal-lysosomal fusion";"EGFR downregulation";"Negative regulation of MET activity";"Endosomal Sorting Complex Required For Transport (ESCRT)";"Clathrin-mediated endocytosis";"Inhibition of membrane repair";"Cargo recognition for clathrin-mediated endocytosis";"Lysosome Vesicle Biogenesis";"Ub-specific processing proteases";"InlB-mediated entry of Listeria monocytogenes into host cell"
XP_046410263.1	2	MetaCyc: PWY-5386;KEGG: 00620+3.1.2.6	"Methylglyoxal degradation I";"Pyruvate metabolism"
XP_046430701.1	16	Reactome: R-HSA-72706;Reactome: R-HSA-2408557;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-975956;Reactome: R-HSA-72702;Reactome: R-HSA-6791226;Reactome: R-HSA-1799339;Reactome: R-HSA-72695;Reactome: R-HSA-192823;Reactome: R-HSA-72689;Reactome: R-HSA-72649;Reactome: R-HSA-72764;Reactome: R-HSA-156902;Reactome: R-HSA-975957	"GTP hydrolysis and joining of the 60S ribosomal subunit";"Selenocysteine synthesis";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Ribosomal scanning and start codon recognition";"Major pathway of rRNA processing in the nucleolus and cytosol";"SRP-dependent cotranslational protein targeting to membrane";"Formation of the ternary complex, and subsequently, the 43S complex";"Viral mRNA Translation";"Formation of a pool of free 40S subunits";"Translation initiation complex formation";"Eukaryotic Translation Termination";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
XP_046415852.1	7	Reactome: R-HSA-69205;Reactome: R-HSA-196757;MetaCyc: PWY-6614;MetaCyc: PWY-3841;KEGG: 00790+1.5.1.3;Reactome: R-HSA-1474151;KEGG: 00670+1.5.1.3	"G1/S-Specific Transcription";"Metabolism of folate and pterines";"Tetrahydrofolate biosynthesis";"Folate transformations II (plants)";"Folate biosynthesis";"Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation";"One carbon pool by folate"
XP_046432472.1	6	KEGG: 05235+3.1.3.16;Reactome: R-HSA-163560;Reactome: R-HSA-2173788;KEGG: 04658+3.1.3.16;Reactome: R-HSA-400253;KEGG: 04660+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Triglyceride catabolism";"Downregulation of TGF-beta receptor signaling";"Th1 and Th2 cell differentiation";"Circadian Clock";"T cell receptor signaling pathway"
XP_046424219.1	1	KEGG: 00860+4.4.1.17	"Porphyrin and chlorophyll metabolism"
XP_046426739.1	8	Reactome: R-HSA-5628897;Reactome: R-HSA-9639288;Reactome: R-HSA-8943724;Reactome: R-HSA-3371571;Reactome: R-HSA-380972;Reactome: R-HSA-165159;Reactome: R-HSA-1632852;Reactome: R-HSA-166208	"TP53 Regulates Metabolic Genes";"Amino acids regulate mTORC1";"Regulation of PTEN gene transcription";"HSF1-dependent transactivation";"Energy dependent regulation of mTOR by LKB1-AMPK";"mTOR signalling";"Macroautophagy";"mTORC1-mediated signalling"
XP_046417183.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046436736.1	2	Reactome: R-HSA-380270;Reactome: R-HSA-380320	"Recruitment of mitotic centrosome proteins and complexes";"Recruitment of NuMA to mitotic centrosomes"
XP_046420193.1	3	Reactome: R-HSA-193648;Reactome: R-HSA-194840;Reactome: R-HSA-416482	"NRAGE signals death through JNK";"Rho GTPase cycle";"G alpha (12/13) signalling events"
XP_046412655.1	4	Reactome: R-HSA-350054;Reactome: R-HSA-2894862;Reactome: R-HSA-2122947;Reactome: R-HSA-2644606	"Notch-HLH transcription pathway";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"NOTCH1 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 PEST Domain Mutants"
XP_046424695.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046409776.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_046436030.1	3	Reactome: R-HSA-5358565;Reactome: R-HSA-5632928;Reactome: R-HSA-5632968	"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"Defective Mismatch Repair Associated With MSH2";"Defective Mismatch Repair Associated With MSH6"
XP_046425432.1	2	Reactome: R-HSA-375280;Reactome: R-HSA-416476	"Amine ligand-binding receptors";"G alpha (q) signalling events"
XP_046427006.1	3	KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway"
XP_046412845.1	2	MetaCyc: PWY-6111;KEGG: 00071+2.3.1.21	"Mitochondrial L-carnitine shuttle";"Fatty acid degradation"
XP_046413774.1	1	Reactome: R-HSA-430039	"mRNA decay by 5' to 3' exoribonuclease"
XP_046424692.1	3	Reactome: R-HSA-6807505;Reactome: R-HSA-76071;Reactome: R-HSA-749476	"RNA polymerase II transcribes snRNA genes";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Abortive And Retractive Initiation"
XP_046414721.1	1	Reactome: R-HSA-432720	"Lysosome Vesicle Biogenesis"
XP_046434130.1	13	MetaCyc: PWY-7883;Reactome: R-HSA-2022857;Reactome: R-HSA-1660662;KEGG: 00511+3.2.1.52;KEGG: 00603+3.2.1.52;KEGG: 00604+3.2.1.52;Reactome: R-HSA-2160916;KEGG: 00531+3.2.1.52;MetaCyc: PWY-6902;MetaCyc: PWY-7822;KEGG: 00513+3.2.1.52;Reactome: R-HSA-2024101;KEGG: 00520+3.2.1.52	"Anhydromuropeptides recycling II";"Keratan sulfate degradation";"Glycosphingolipid metabolism";"Other glycan degradation";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Glycosphingolipid biosynthesis - ganglio series";"Hyaluronan uptake and degradation";"Glycosaminoglycan degradation";"Chitin degradation II (Vibrio)";"Chitin degradation III (Serratia)";"Various types of N-glycan biosynthesis";"CS/DS degradation";"Amino sugar and nucleotide sugar metabolism"
XP_046419633.1	2	Reactome: R-HSA-8951664;Reactome: R-HSA-983168	"Neddylation";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046423290.1	2	Reactome: R-HSA-8949613;Reactome: R-HSA-1268020	"Cristae formation";"Mitochondrial protein import"
XP_046428501.1	5	KEGG: 00330+1.5.1.2;MetaCyc: PWY-4981;MetaCyc: PWY-6344;Reactome: R-HSA-8964539;MetaCyc: PWY-3341	"Arginine and proline metabolism";"L-proline biosynthesis II (from arginine)";"L-ornithine degradation II (Stickland reaction)";"Glutamate and glutamine metabolism";"L-proline biosynthesis III (from L-ornithine)"
XP_046432714.1	6	Reactome: R-HSA-975578;KEGG: 00513+2.4.1.143;MetaCyc: PWY-7920;Reactome: R-HSA-4793952;MetaCyc: PWY-7426;KEGG: 00510+2.4.1.143	"Reactions specific to the complex N-glycan synthesis pathway";"Various types of N-glycan biosynthesis";"Complex N-linked glycan biosynthesis (plants)";"Defective MGAT2 causes MGAT2-CDG (CDG-2a)";"Complex N-linked glycan biosynthesis (vertebrates)";"N-Glycan biosynthesis"
XP_046410836.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_046424917.1	3	Reactome: R-HSA-983168;MetaCyc: PWY-7511;Reactome: R-HSA-6798695	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination";"Neutrophil degranulation"
XP_046420386.1	2	Reactome: R-HSA-6811434;Reactome: R-HSA-6807878	"COPI-dependent Golgi-to-ER retrograde traffic";"COPI-mediated anterograde transport"
XP_046418115.1	6	KEGG: 00600+3.2.1.23;KEGG: 00511+3.2.1.23;KEGG: 00531+3.2.1.23;KEGG: 00052+3.2.1.23;KEGG: 00604+3.2.1.23;MetaCyc: PWY-6807	"Sphingolipid metabolism";"Other glycan degradation";"Glycosaminoglycan degradation";"Galactose metabolism";"Glycosphingolipid biosynthesis - ganglio series";"Xyloglucan degradation II (exoglucanase)"
XP_046413290.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_046416521.1	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
XP_046418314.1	1	Reactome: R-HSA-8849932	"Synaptic adhesion-like molecules"
XP_046436717.1	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
XP_046413169.1	1	KEGG: 00760+2.3.1.286	"Nicotinate and nicotinamide metabolism"
XP_046434701.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_046419595.1	3	KEGG: 00010+5.1.3.3;KEGG: 00052+5.1.3.3;MetaCyc: PWY-6317	"Glycolysis / Gluconeogenesis";"Galactose metabolism";"D-galactose degradation I (Leloir pathway)"
XP_046430111.1	1	Reactome: R-HSA-6790901	"rRNA modification in the nucleus and cytosol"
XP_046420184.1	2	Reactome: R-HSA-6783310;Reactome: R-HSA-6796648	"Fanconi Anemia Pathway";"TP53 Regulates Transcription of DNA Repair Genes"
XP_046432201.1	4	Reactome: R-HSA-375165;Reactome: R-HSA-6807878;Reactome: R-HSA-445095;Reactome: R-HSA-5673001	"NCAM signaling for neurite out-growth";"COPI-mediated anterograde transport";"Interaction between L1 and Ankyrins";"RAF/MAP kinase cascade"
XP_046428272.1	1	Reactome: R-HSA-83936	"Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"
XP_046435582.1	6	KEGG: 00520+2.7.7.12;MetaCyc: PWY-6527;Reactome: R-HSA-5609978;KEGG: 00052+2.7.7.12;MetaCyc: PWY-6317;Reactome: R-HSA-70370	"Amino sugar and nucleotide sugar metabolism";"Stachyose degradation";"Defective GALT can cause Galactosemia";"Galactose metabolism";"D-galactose degradation I (Leloir pathway)";"Galactose catabolism"
XP_046412157.1	1	Reactome: R-HSA-6814848	"Glycerophospholipid catabolism"
XP_046410959.1	2	Reactome: R-HSA-352230;Reactome: R-HSA-442660	"Amino acid transport across the plasma membrane";"Na+/Cl- dependent neurotransmitter transporters"
XP_046433084.1	3	Reactome: R-HSA-6798695;Reactome: R-HSA-202427;Reactome: R-HSA-6807004	"Neutrophil degranulation";"Phosphorylation of CD3 and TCR zeta chains";"Negative regulation of MET activity"
XP_046428271.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_046411870.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
XP_046413835.1	13	Reactome: R-HSA-192823;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-72689;Reactome: R-HSA-9633012;Reactome: R-HSA-1799339;Reactome: R-HSA-2408557;Reactome: R-HSA-72706;Reactome: R-HSA-6791226;Reactome: R-HSA-975957;Reactome: R-HSA-72764;Reactome: R-HSA-975956;Reactome: R-HSA-156902	"Viral mRNA Translation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Formation of a pool of free 40S subunits";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"SRP-dependent cotranslational protein targeting to membrane";"Selenocysteine synthesis";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Peptide chain elongation"
XP_046411061.1	7	Reactome: R-HSA-2644606;Reactome: R-HSA-9013507;Reactome: R-HSA-2122948;Reactome: R-HSA-2894862;Reactome: R-HSA-2691232;Reactome: R-HSA-2660826;Reactome: R-HSA-2979096	"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Activated NOTCH1 Transmits Signal to the Nucleus";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Constitutive Signaling by NOTCH1 HD Domain Mutants";"Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant";"NOTCH2 Activation and Transmission of Signal to the Nucleus"
XP_046410718.1	2	Reactome: R-HSA-1236394;Reactome: R-HSA-977443	"Signaling by ERBB4";"GABA receptor activation"
XP_046434448.1	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
XP_046424009.1	1	Reactome: R-HSA-8873719	"RAB geranylgeranylation"
XP_046410043.1	1	Reactome: R-HSA-196108	"Pregnenolone biosynthesis"
XP_046429691.1	1	Reactome: R-HSA-388844	"Receptor-type tyrosine-protein phosphatases"
XP_046433863.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_046428058.1	1	Reactome: R-HSA-6811434	"COPI-dependent Golgi-to-ER retrograde traffic"
XP_046426158.1	4	MetaCyc: PWY-8026;KEGG: 00100+1.3.1.72;Reactome: R-HSA-6807062;Reactome: R-HSA-6807047	"Sterol biosynthesis (methylotrophs)";"Steroid biosynthesis";"Cholesterol biosynthesis via lathosterol";"Cholesterol biosynthesis via desmosterol"
XP_046431120.1	2	Reactome: R-HSA-445355;Reactome: R-HSA-390522	"Smooth Muscle Contraction";"Striated Muscle Contraction"
XP_046428307.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046435308.1	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
XP_046418003.1	1	Reactome: R-HSA-72165	"mRNA Splicing - Minor Pathway"
XP_046431848.1	2	Reactome: R-HSA-3214858;Reactome: R-HSA-8939243	"RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"
XP_046420806.1	5	KEGG: 00250+6.3.5.4;Reactome: R-HSA-9633012;Reactome: R-HSA-8963693;Reactome: R-HSA-380994;Reactome: R-HSA-9648895	"Alanine, aspartate and glutamate metabolism";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Aspartate and asparagine metabolism";"ATF4 activates genes in response to endoplasmic reticulum stress";"Response of EIF2AK1 (HRI) to heme deficiency"
XP_046431672.1	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
XP_046428832.1	7	Reactome: R-HSA-2894862;Reactome: R-HSA-2122947;Reactome: R-HSA-2173796;Reactome: R-HSA-2644606;Reactome: R-HSA-212436;Reactome: R-HSA-1989781;Reactome: R-HSA-381340	"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"NOTCH1 Intracellular Domain Regulates Transcription";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Generic Transcription Pathway";"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation"
XP_046422731.1	4	Reactome: R-HSA-352230;Reactome: R-HSA-71240;Reactome: R-HSA-5660862;Reactome: R-HSA-210991	"Amino acid transport across the plasma membrane";"Tryptophan catabolism";"Defective SLC7A7 causes lysinuric protein intolerance (LPI)";"Basigin interactions"
XP_046415045.1	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
XP_046423264.1	17	KEGG: 00254+6.4.1.2;MetaCyc: PWY-6722;MetaCyc: PWY-5744;KEGG: 00620+6.4.1.2;Reactome: R-HSA-163765;Reactome: R-HSA-196780;KEGG: 00640+6.4.1.2;Reactome: R-HSA-200425;MetaCyc: PWY-5966-1;MetaCyc: PWY-5789;Reactome: R-HSA-3371599;KEGG: 00061+6.4.1.2;MetaCyc: PWY-4381;KEGG: 00720+6.4.1.2;Reactome: R-HSA-2426168;MetaCyc: PWY-5743;MetaCyc: PWY-6679	"Aflatoxin biosynthesis";"Candicidin biosynthesis";"Glyoxylate assimilation";"Pyruvate metabolism";"ChREBP activates metabolic gene expression";"Biotin transport and metabolism";"Propanoate metabolism";"Carnitine metabolism";"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Defective HLCS causes multiple carboxylase deficiency";"Fatty acid biosynthesis";"Fatty acid biosynthesis initiation (bacteria and plants)";"Carbon fixation pathways in prokaryotes";"Activation of gene expression by SREBF (SREBP)";"3-hydroxypropanoate cycle";"Jadomycin biosynthesis"
XP_046429711.1	2	MetaCyc: PWY-6281;KEGG: 00970+6.1.1.11	"L-selenocysteine biosynthesis II (archaea and eukaryotes)";"Aminoacyl-tRNA biosynthesis"
XP_046409406.1	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
XP_046430760.1	26	Reactome: R-HSA-9648025;Reactome: R-HSA-380320;Reactome: R-HSA-9609690;Reactome: R-HSA-2467813;Reactome: R-HSA-6811434;Reactome: R-HSA-5626467;Reactome: R-HSA-6807878;Reactome: R-HSA-9619483;Reactome: R-HSA-1445148;Reactome: R-HSA-389960;Reactome: R-HSA-983189;Reactome: R-HSA-2500257;Reactome: R-HSA-8955332;Reactome: R-HSA-9609736;Reactome: R-HSA-190840;Reactome: R-HSA-68877;Reactome: R-HSA-8852276;Reactome: R-HSA-9646399;Reactome: R-HSA-6811436;Reactome: R-HSA-190861;Reactome: R-HSA-5617833;Reactome: R-HSA-2132295;Reactome: R-HSA-3371497;Reactome: R-HSA-5663220;Reactome: R-HSA-437239;Reactome: R-HSA-389977	"EML4 and NUDC in mitotic spindle formation";"Recruitment of NuMA to mitotic centrosomes";"HCMV Early Events";"Separation of Sister Chromatids";"COPI-dependent Golgi-to-ER retrograde traffic";"RHO GTPases activate IQGAPs";"COPI-mediated anterograde transport";"Activation of AMPK downstream of NMDARs";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Formation of tubulin folding intermediates by CCT/TriC";"Kinesins";"Resolution of Sister Chromatid Cohesion";"Carboxyterminal post-translational modifications of tubulin";"Assembly and cell surface presentation of NMDA receptors";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Mitotic Prometaphase";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Aggrephagy";"COPI-independent Golgi-to-ER retrograde traffic";"Gap junction assembly";"Cilium Assembly";"MHC class II antigen presentation";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"RHO GTPases Activate Formins";"Recycling pathway of L1";"Post-chaperonin tubulin folding pathway"
XP_046416658.1	1	Reactome: R-HSA-5576886	"Phase 4 - resting membrane potential"
XP_046434927.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046430931.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_046430681.1	3	KEGG: 00770+2.7.1.33;Reactome: R-HSA-196783;MetaCyc: PWY-3961	"Pantothenate and CoA biosynthesis";"Coenzyme A biosynthesis";"Phosphopantothenate biosynthesis II"
XP_046436473.1	2	Reactome: R-HSA-6807878;Reactome: R-HSA-445095	"COPI-mediated anterograde transport";"Interaction between L1 and Ankyrins"
XP_046424714.1	1	Reactome: R-HSA-1474228	"Degradation of the extracellular matrix"
XP_046432442.1	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
XP_046436690.1	12	Reactome: R-HSA-141444;Reactome: R-HSA-9648025;Reactome: R-HSA-6811436;Reactome: R-HSA-2467813;Reactome: R-HSA-9646399;Reactome: R-HSA-9609690;Reactome: R-HSA-68877;Reactome: R-HSA-2132295;Reactome: R-HSA-3371497;Reactome: R-HSA-6807878;Reactome: R-HSA-2500257;Reactome: R-HSA-5663220	"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"EML4 and NUDC in mitotic spindle formation";"COPI-independent Golgi-to-ER retrograde traffic";"Separation of Sister Chromatids";"Aggrephagy";"HCMV Early Events";"Mitotic Prometaphase";"MHC class II antigen presentation";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-mediated anterograde transport";"Resolution of Sister Chromatid Cohesion";"RHO GTPases Activate Formins"
XP_046418470.1	4	Reactome: R-HSA-749476;Reactome: R-HSA-76071;Reactome: R-HSA-76061;Reactome: R-HSA-76066	"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Transcription Initiation From Type 2 Promoter"
XP_046427200.1	3	Reactome: R-HSA-110357;Reactome: R-HSA-110328;Reactome: R-HSA-110329	"Displacement of DNA glycosylase by APEX1";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"Cleavage of the damaged pyrimidine"
XP_046421037.1	2	Reactome: R-HSA-3295583;Reactome: R-HSA-418890	"TRP channels";"Role of second messengers in netrin-1 signaling"
XP_046409811.1	4	KEGG: 00514+2.4.1.255;Reactome: R-HSA-3214847;Reactome: R-HSA-5689603;MetaCyc: PWY-7437	"Other types of O-glycan biosynthesis";"HATs acetylate histones";"UCH proteinases";"Protein O-[N-acetyl]-glucosylation"
XP_046413576.1	1	Reactome: R-HSA-72165	"mRNA Splicing - Minor Pathway"
XP_046422093.1	1	Reactome: R-HSA-8964038	"LDL clearance"
XP_046412947.1	4	Reactome: R-HSA-73817;KEGG: 00230+6.3.5.2;MetaCyc: PWY-7221;KEGG: 00983+6.3.5.2	"Purine ribonucleoside monophosphate biosynthesis";"Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis";"Drug metabolism - other enzymes"
XP_046412468.1	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046435365.1	2	Reactome: R-HSA-8856825;Reactome: R-HSA-8856828	"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis"
XP_046424900.1	6	Reactome: R-HSA-450385;Reactome: R-HSA-6791226;Reactome: R-HSA-429958;Reactome: R-HSA-380994;Reactome: R-HSA-450513;Reactome: R-HSA-450604	"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"Major pathway of rRNA processing in the nucleolus and cytosol";"mRNA decay by 3' to 5' exoribonuclease";"ATF4 activates genes in response to endoplasmic reticulum stress";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"KSRP (KHSRP) binds and destabilizes mRNA"
XP_046431918.1	3	MetaCyc: PWY-7999;Reactome: R-HSA-159740;KEGG: 00130+4.1.1.90	"Vitamin K-epoxide cycle";"Gamma-carboxylation of protein precursors";"Ubiquinone and other terpenoid-quinone biosynthesis"
XP_046422221.1	5	Reactome: R-HSA-389960;Reactome: R-HSA-389957;Reactome: R-HSA-390450;Reactome: R-HSA-390471;Reactome: R-HSA-6814122	"Formation of tubulin folding intermediates by CCT/TriC";"Prefoldin mediated transfer of substrate to CCT/TriC";"Folding of actin by CCT/TriC";"Association of TriC/CCT with target proteins during biosynthesis";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"
XP_046416569.1	1	Reactome: R-HSA-420499	"Class C/3 (Metabotropic glutamate/pheromone receptors)"
XP_046426377.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046424178.1	2	MetaCyc: PWY-6854;Reactome: R-HSA-3299685	"Ethylene biosynthesis III (microbes)";"Detoxification of Reactive Oxygen Species"
XP_046409767.1	12	Reactome: R-HSA-194840;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;Reactome: R-HSA-418885;KEGG: 04151+2.7.11.1;Reactome: R-HSA-416482;KEGG: 04150+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;Reactome: R-HSA-193648;Reactome: R-HSA-416476	"Rho GTPase cycle";"Thermogenesis";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"DCC mediated attractive signaling";"PI3K-Akt signaling pathway";"G alpha (12/13) signalling events";"mTOR signaling pathway";"Human cytomegalovirus infection";"Relaxin signaling pathway";"NRAGE signals death through JNK";"G alpha (q) signalling events"
XP_046409621.1	5	MetaCyc: PWY-5981;MetaCyc: PWY-5667;MetaCyc: PWY-7817;KEGG: 00564+2.7.7.41;KEGG: 04070+2.7.7.41	"CDP-diacylglycerol biosynthesis III";"CDP-diacylglycerol biosynthesis I";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Glycerophospholipid metabolism";"Phosphatidylinositol signaling system"
XP_046431559.1	1	Reactome: R-HSA-1799339	"SRP-dependent cotranslational protein targeting to membrane"
XP_046433453.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_046410998.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046419269.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_046415328.1	1	Reactome: R-HSA-3108214	"SUMOylation of DNA damage response and repair proteins"
XP_046420333.1	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276	"Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination"
XP_046411246.1	2	Reactome: R-HSA-430039;Reactome: R-HSA-72163	"mRNA decay by 5' to 3' exoribonuclease";"mRNA Splicing - Major Pathway"
XP_046415446.1	31	KEGG: 00780+1.1.1.100+4.2.1.59+2.3.1.41;MetaCyc: PWY-5367;MetaCyc: PWY-5142;MetaCyc: PWY-7664;Reactome: R-HSA-2426168;MetaCyc: PWY-8012;MetaCyc: PWY-8049;MetaCyc: PWYG-321;Reactome: R-HSA-199220;MetaCyc: PWY-4381;MetaCyc: PWY-6799;MetaCyc: PWY-5966-1;MetaCyc: PWY-7388;MetaCyc: PWY-5994;MetaCyc: PWY-6113;MetaCyc: PWY-7663;MetaCyc: PWY-6519;MetaCyc: PWY-5971;Reactome: R-HSA-163765;MetaCyc: PWY-5973;KEGG: 00061+1.1.1.100+2.3.1.85+4.2.1.59+2.3.1.39+2.3.1.41+3.1.2.14;MetaCyc: PWY-8047;Reactome: R-HSA-75105;MetaCyc: PWY-6282;MetaCyc: PWY-7858;Reactome: R-HSA-9029558;MetaCyc: PWY-5147;MetaCyc: PWY-7746;MetaCyc: PWY-5989;MetaCyc: PWY-7723;MetaCyc: PWY-5366	"Biotin metabolism";"Petroselinate biosynthesis";"Acyl-[acyl-carrier protein] thioesterase pathway";"Oleate biosynthesis IV (anaerobic)";"Activation of gene expression by SREBF (SREBP)";"Mupirocin biosynthesis";"Pederin biosynthesis";"";"Vitamin B5 (pantothenate) metabolism";"Fatty acid biosynthesis initiation (bacteria and plants)";"Fatty acid biosynthesis initiation (plant mitochondria)";"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)";"Octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast)";"Palmitate biosynthesis (animals and fungi, cytoplasm)";"Superpathway of mycolate biosynthesis";"Gondoate biosynthesis (anaerobic)";"8-amino-7-oxononanoate biosynthesis I";"Palmitate biosynthesis II (bacteria and plant cytoplasm)";"ChREBP activates metabolic gene expression";"Cis-vaccenate biosynthesis";"Fatty acid biosynthesis";"Bryostatin biosynthesis";"Fatty acyl-CoA biosynthesis";"Palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate)";"(5Z)-dodecenoate biosynthesis II";"NR1H2 & NR1H3 regulate gene expression linked to lipogenesis";"Oleate biosynthesis I (plants)";"Mycobacterial sulfolipid biosynthesis";"Stearate biosynthesis II (bacteria and plants)";"Bacterial bioluminescence";"Palmitoleate biosynthesis II (plants and bacteria)"
XP_046433075.1	6	Reactome: R-HSA-8874081;Reactome: R-HSA-3000171;Reactome: R-HSA-1650814;Reactome: R-HSA-8948216;Reactome: R-HSA-2022090;Reactome: R-HSA-1442490	"MET activates PTK2 signaling";"Non-integrin membrane-ECM interactions";"Collagen biosynthesis and modifying enzymes";"Collagen chain trimerization";"Assembly of collagen fibrils and other multimeric structures";"Collagen degradation"
XP_046435663.1	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
XP_046411470.1	5	MetaCyc: PWY-7269;KEGG: 00760+2.7.1.23;MetaCyc: PWY-5083;MetaCyc: PWY-7268;Reactome: R-HSA-196807	"NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)";"Nicotinate and nicotinamide metabolism";"NAD/NADH phosphorylation and dephosphorylation";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"Nicotinate metabolism"
XP_046430779.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_046432705.1	1	Reactome: R-HSA-381753	"Olfactory Signaling Pathway"
XP_046436625.1	1	Reactome: R-HSA-2428928	"IRS-related events triggered by IGF1R"
XP_046416263.1	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840	"Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation"
XP_046415684.1	2	Reactome: R-HSA-445095;Reactome: R-HSA-5576892	"Interaction between L1 and Ankyrins";"Phase 0 - rapid depolarisation"
XP_046412081.1	1	Reactome: R-HSA-5663220	"RHO GTPases Activate Formins"
XP_046423346.1	2	Reactome: R-HSA-180024;KEGG: 00230+3.1.4.53	"DARPP-32 events";"Purine metabolism"
XP_046424685.1	5	KEGG: 00514+2.4.1.109;MetaCyc: PWY-7921;MetaCyc: PWY-7922;MetaCyc: PWY-7979;KEGG: 00515+2.4.1.109	"Other types of O-glycan biosynthesis";"Protein O-mannosylation I (yeast)";"Protein O-mannosylation II (mammals, core M1 and core M2)";"Protein O-mannosylation III (mammals, core M3)";"Mannose type O-glycan biosynthesis"
XP_046426208.1	33	Reactome: R-HSA-168271;Reactome: R-HSA-4615885;Reactome: R-HSA-191859;Reactome: R-HSA-159230;Reactome: R-HSA-5619107;Reactome: R-HSA-168276;Reactome: R-HSA-4551638;Reactome: R-HSA-2500257;Reactome: R-HSA-3371453;Reactome: R-HSA-3232142;Reactome: R-HSA-2467813;Reactome: R-HSA-3108214;Reactome: R-HSA-159231;Reactome: R-HSA-1169408;Reactome: R-HSA-9648025;Reactome: R-HSA-9610379;Reactome: R-HSA-168333;Reactome: R-HSA-159227;Reactome: R-HSA-5663220;Reactome: R-HSA-68877;Reactome: R-HSA-5578749;Reactome: R-HSA-180746;Reactome: R-HSA-3301854;Reactome: R-HSA-4085377;Reactome: R-HSA-165054;Reactome: R-HSA-6784531;Reactome: R-HSA-180910;Reactome: R-HSA-170822;Reactome: R-HSA-168325;Reactome: R-HSA-9609690;Reactome: R-HSA-159236;Reactome: R-HSA-141444;Reactome: R-HSA-4570464	"Transport of Ribonucleoproteins into the Host Nucleus";"SUMOylation of DNA replication proteins";"snRNP Assembly";"Transport of the SLBP Dependant Mature mRNA";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"NS1 Mediated Effects on Host Pathways";"SUMOylation of chromatin organization proteins";"Resolution of Sister Chromatid Cohesion";"Regulation of HSF1-mediated heat shock response";"SUMOylation of ubiquitinylation proteins";"Separation of Sister Chromatids";"SUMOylation of DNA damage response and repair proteins";"Transport of Mature mRNA Derived from an Intronless Transcript";"ISG15 antiviral mechanism";"EML4 and NUDC in mitotic spindle formation";"HCMV Late Events";"NEP/NS2 Interacts with the Cellular Export Machinery";"Transport of the SLBP independent Mature mRNA";"RHO GTPases Activate Formins";"Mitotic Prometaphase";"Transcriptional regulation by small RNAs";"Nuclear import of Rev protein";"Nuclear Pore Complex (NPC) Disassembly";"SUMOylation of SUMOylation proteins";"Rev-mediated nuclear export of HIV RNA";"tRNA processing in the nucleus";"Vpr-mediated nuclear import of PICs";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Viral Messenger RNA Synthesis";"HCMV Early Events";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"SUMOylation of RNA binding proteins"
XP_046433534.1	2	Reactome: R-HSA-446199;Reactome: R-HSA-4755609	"Synthesis of Dolichyl-phosphate";"Defective DHDDS causes retinitis pigmentosa 59"
XP_046413908.1	10	MetaCyc: PWY-8053;MetaCyc: PWY-7587;MetaCyc: PWY-7411;Reactome: R-HSA-1483166;MetaCyc: PWY-5667;KEGG: 00564+2.3.1.15;KEGG: 00561+2.3.1.15;MetaCyc: PWY-8055;MetaCyc: PWY-8051;MetaCyc: PWY-6453	"Anandamide biosynthesis II";"Oleate biosynthesis III (cyanobacteria)";"Phosphatidate biosynthesis (yeast)";"Synthesis of PA";"CDP-diacylglycerol biosynthesis I";"Glycerophospholipid metabolism";"Glycerolipid metabolism";"Palmitoyl ethanolamide biosynthesis";"Anandamide biosynthesis I";"Stigma estolide biosynthesis"
XP_046418326.1	7	Reactome: R-HSA-1362300;Reactome: R-HSA-156711;Reactome: R-HSA-69656;Reactome: R-HSA-1538133;Reactome: R-HSA-69202;Reactome: R-HSA-69205;Reactome: R-HSA-1362277	"Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1";"Polo-like kinase mediated events";"Cyclin A:Cdk2-associated events at S phase entry";"G0 and Early G1";"Cyclin E associated events during G1/S transition";"G1/S-Specific Transcription";"Transcription of E2F targets under negative control by DREAM complex"
XP_046416090.1	2	Reactome: R-HSA-203927;Reactome: R-HSA-8986944	"MicroRNA (miRNA) biogenesis";"Transcriptional Regulation by MECP2"
XP_046423458.1	19	Reactome: R-HSA-418885;Reactome: R-HSA-5627123;Reactome: R-HSA-8964616;Reactome: R-HSA-182971;Reactome: R-HSA-2029482;Reactome: R-HSA-5625970;Reactome: R-HSA-983231;Reactome: R-HSA-8950505;Reactome: R-HSA-5663220;Reactome: R-HSA-5687128;Reactome: R-HSA-114604;Reactome: R-HSA-4420097;Reactome: R-HSA-5663213;Reactome: R-HSA-428543;Reactome: R-HSA-389359;Reactome: R-HSA-194840;Reactome: R-HSA-3928662;Reactome: R-HSA-5626467;Reactome: R-HSA-525793	"DCC mediated attractive signaling";"RHO GTPases activate PAKs";"G beta:gamma signalling through CDC42";"EGFR downregulation";"Regulation of actin dynamics for phagocytic cup formation";"RHO GTPases activate KTN1";"Factors involved in megakaryocyte development and platelet production";"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation";"RHO GTPases Activate Formins";"MAPK6/MAPK4 signaling";"GPVI-mediated activation cascade";"VEGFA-VEGFR2 Pathway";"RHO GTPases Activate WASPs and WAVEs";"Inactivation of CDC42 and RAC1";"CD28 dependent Vav1 pathway";"Rho GTPase cycle";"EPHB-mediated forward signaling";"RHO GTPases activate IQGAPs";"Myogenesis"
XP_046425956.1	29	Reactome: R-HSA-5696400;Reactome: R-HSA-167158;Reactome: R-HSA-6781827;Reactome: R-HSA-6782135;Reactome: R-HSA-73779;Reactome: R-HSA-167160;Reactome: R-HSA-73762;Reactome: R-HSA-427413;Reactome: R-HSA-75953;Reactome: R-HSA-167162;Reactome: R-HSA-6781823;Reactome: R-HSA-167246;Reactome: R-HSA-113418;Reactome: R-HSA-6782210;Reactome: R-HSA-73776;Reactome: R-HSA-72086;Reactome: R-HSA-674695;Reactome: R-HSA-77075;Reactome: R-HSA-6796648;Reactome: R-HSA-167200;Reactome: R-HSA-73772;Reactome: R-HSA-5696395;Reactome: R-HSA-167161;Reactome: R-HSA-167152;Reactome: R-HSA-76042;Reactome: R-HSA-75955;Reactome: R-HSA-167172;Reactome: R-HSA-73863;Reactome: R-HSA-112382	"Dual Incision in GG-NER";"Formation of the HIV-1 Early Elongation Complex";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Dual incision in TC-NER";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"RNA Polymerase I Transcription Initiation";"NoRC negatively regulates rRNA expression";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II HIV Promoter Escape";"Formation of TC-NER Pre-Incision Complex";"Tat-mediated elongation of the HIV-1 transcript";"Formation of the Early Elongation Complex";"Gap-filling DNA repair synthesis and ligation in TC-NER";"RNA Polymerase II Promoter Escape";"mRNA Capping";"RNA Polymerase II Pre-transcription Events";"RNA Pol II CTD phosphorylation and interaction with CE";"TP53 Regulates Transcription of DNA Repair Genes";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Polymerase I Promoter Escape";"Formation of Incision Complex in GG-NER";"HIV Transcription Initiation";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II Transcription Elongation";"Transcription of the HIV genome";"RNA Polymerase I Transcription Termination";"Formation of RNA Pol II elongation complex"
XP_046430270.1	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840	"Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation"
XP_046434128.1	1	Reactome: R-HSA-5662702	"Melanin biosynthesis"
XP_046436629.1	1	Reactome: R-HSA-5601884	"PIWI-interacting RNA (piRNA) biogenesis"
XP_046410383.1	7	KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1	"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Relaxin signaling pathway";"Thermogenesis";"Human cytomegalovirus infection"
XP_046419003.1	2	Reactome: R-HSA-5357905;Reactome: R-HSA-5357956	"Regulation of TNFR1 signaling";"TNFR1-induced NFkappaB signaling pathway"
XP_046416856.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_046435643.1	7	Reactome: R-HSA-5620912;Reactome: R-HSA-380284;Reactome: R-HSA-380259;Reactome: R-HSA-8854518;Reactome: R-HSA-2565942;Reactome: R-HSA-380270;Reactome: R-HSA-380320	"Anchoring of the basal body to the plasma membrane";"Loss of proteins required for interphase microtubule organization from the centrosome";"Loss of Nlp from mitotic centrosomes";"AURKA Activation by TPX2";"Regulation of PLK1 Activity at G2/M Transition";"Recruitment of mitotic centrosome proteins and complexes";"Recruitment of NuMA to mitotic centrosomes"
XP_046434629.1	2	Reactome: R-HSA-1799339;Reactome: R-HSA-6798695	"SRP-dependent cotranslational protein targeting to membrane";"Neutrophil degranulation"
XP_046434904.1	30	Reactome: R-HSA-427413;Reactome: R-HSA-75953;Reactome: R-HSA-6781823;Reactome: R-HSA-167246;Reactome: R-HSA-167162;Reactome: R-HSA-113418;Reactome: R-HSA-6782210;Reactome: R-HSA-6781827;Reactome: R-HSA-167158;Reactome: R-HSA-5696400;Reactome: R-HSA-73779;Reactome: R-HSA-2564830;Reactome: R-HSA-6782135;Reactome: R-HSA-73762;Reactome: R-HSA-167160;Reactome: R-HSA-76042;Reactome: R-HSA-167172;Reactome: R-HSA-75955;Reactome: R-HSA-112382;Reactome: R-HSA-73863;Reactome: R-HSA-72086;Reactome: R-HSA-674695;Reactome: R-HSA-73776;Reactome: R-HSA-167200;Reactome: R-HSA-77075;Reactome: R-HSA-6796648;Reactome: R-HSA-73772;Reactome: R-HSA-5696395;Reactome: R-HSA-167161;Reactome: R-HSA-167152	"NoRC negatively regulates rRNA expression";"RNA Polymerase II Transcription Initiation";"Formation of TC-NER Pre-Incision Complex";"Tat-mediated elongation of the HIV-1 transcript";"RNA Polymerase II HIV Promoter Escape";"Formation of the Early Elongation Complex";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Formation of the HIV-1 Early Elongation Complex";"Dual Incision in GG-NER";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Cytosolic iron-sulfur cluster assembly";"Dual incision in TC-NER";"RNA Polymerase I Transcription Initiation";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Transcription of the HIV genome";"RNA Polymerase II Transcription Elongation";"Formation of RNA Pol II elongation complex";"RNA Polymerase I Transcription Termination";"mRNA Capping";"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Promoter Escape";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Pol II CTD phosphorylation and interaction with CE";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Polymerase I Promoter Escape";"Formation of Incision Complex in GG-NER";"HIV Transcription Initiation";"Formation of HIV elongation complex in the absence of HIV Tat"
XP_046415773.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_046422872.1	1	Reactome: R-HSA-6794361	"Neurexins and neuroligins"
XP_046412937.1	1	Reactome: R-HSA-1632852	"Macroautophagy"
XP_046430937.1	2	Reactome: R-HSA-3214858;Reactome: R-HSA-8939243	"RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"
XP_046433350.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046418639.1	4	Reactome: R-HSA-8856825;Reactome: R-HSA-5696394;Reactome: R-HSA-8951664;Reactome: R-HSA-6781823	"Cargo recognition for clathrin-mediated endocytosis";"DNA Damage Recognition in GG-NER";"Neddylation";"Formation of TC-NER Pre-Incision Complex"
XP_046430580.1	1	Reactome: R-HSA-426117	"Cation-coupled Chloride cotransporters"
XP_046436055.1	2	Reactome: R-HSA-2408522;Reactome: R-HSA-379716	"Selenoamino acid metabolism";"Cytosolic tRNA aminoacylation"
XP_046427694.1	7	Reactome: R-HSA-2500257;Reactome: R-HSA-5663220;Reactome: R-HSA-2467813;Reactome: R-HSA-68877;Reactome: R-HSA-606279;Reactome: R-HSA-141444;Reactome: R-HSA-9648025	"Resolution of Sister Chromatid Cohesion";"RHO GTPases Activate Formins";"Separation of Sister Chromatids";"Mitotic Prometaphase";"Deposition of new CENPA-containing nucleosomes at the centromere";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"EML4 and NUDC in mitotic spindle formation"
XP_046434868.1	1	Reactome: R-HSA-1445148	"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
XP_046417186.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046414600.1	1	Reactome: R-HSA-1660661	"Sphingolipid de novo biosynthesis"
XP_046430587.1	1	Reactome: R-HSA-426117	"Cation-coupled Chloride cotransporters"
XP_046433473.1	2	Reactome: R-HSA-6798695;Reactome: R-HSA-8964038	"Neutrophil degranulation";"LDL clearance"
XP_046427624.1	2	Reactome: R-HSA-189085;KEGG: 00500+3.2.1.28	"Digestion of dietary carbohydrate";"Starch and sucrose metabolism"
XP_046432156.1	1	Reactome: R-HSA-390522	"Striated Muscle Contraction"
XP_046427314.1	5	Reactome: R-HSA-918233;Reactome: R-HSA-9013973;Reactome: R-HSA-933541;Reactome: R-HSA-936964;Reactome: R-HSA-936440	"TRAF3-dependent IRF activation pathway";"TICAM1-dependent activation of IRF3/IRF7";"TRAF6 mediated IRF7 activation";"Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon";"Negative regulators of DDX58/IFIH1 signaling"
XP_046417792.1	1	Reactome: R-HSA-442660	"Na+/Cl- dependent neurotransmitter transporters"
XP_046435530.1	2	Reactome: R-HSA-400253;Reactome: R-HSA-2151201	"Circadian Clock";"Transcriptional activation of mitochondrial biogenesis"
XP_046426404.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046417578.1	12	Reactome: R-HSA-674695;Reactome: R-HSA-167287;Reactome: R-HSA-167200;Reactome: R-HSA-6796648;Reactome: R-HSA-167290;Reactome: R-HSA-167152;Reactome: R-HSA-6804756;Reactome: R-HSA-167246;Reactome: R-HSA-75955;Reactome: R-HSA-112382;Reactome: R-HSA-167238;Reactome: R-HSA-167243	"RNA Polymerase II Pre-transcription Events";"HIV elongation arrest and recovery";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"TP53 Regulates Transcription of DNA Repair Genes";"Pausing and recovery of HIV elongation";"Formation of HIV elongation complex in the absence of HIV Tat";"Regulation of TP53 Activity through Phosphorylation";"Tat-mediated elongation of the HIV-1 transcript";"RNA Polymerase II Transcription Elongation";"Formation of RNA Pol II elongation complex";"Pausing and recovery of Tat-mediated HIV elongation";"Tat-mediated HIV elongation arrest and recovery"
XP_046421475.1	1	Reactome: R-HSA-435368	"Zinc efflux and compartmentalization by the SLC30 family"
XP_046420191.1	3	Reactome: R-HSA-193648;Reactome: R-HSA-416482;Reactome: R-HSA-194840	"NRAGE signals death through JNK";"G alpha (12/13) signalling events";"Rho GTPase cycle"
XP_046410606.1	57	Reactome: R-HSA-1236978;Reactome: R-HSA-4608870;Reactome: R-HSA-4641257;Reactome: R-HSA-75815;Reactome: R-HSA-202424;Reactome: R-HSA-174084;Reactome: R-HSA-5689880;Reactome: R-HSA-8951664;Reactome: R-HSA-349425;Reactome: R-HSA-8939236;Reactome: R-HSA-5678895;Reactome: R-HSA-180585;Reactome: R-HSA-5610785;Reactome: R-HSA-6798695;Reactome: R-HSA-5607761;Reactome: R-HSA-5658442;Reactome: R-HSA-983168;Reactome: R-HSA-2467813;Reactome: R-HSA-174154;Reactome: R-HSA-174184;Reactome: R-HSA-8939902;Reactome: R-HSA-174113;Reactome: R-HSA-5687128;Reactome: R-HSA-9020702;Reactome: R-HSA-8854050;Reactome: R-HSA-1234176;Reactome: R-HSA-8948751;Reactome: R-HSA-69481;Reactome: R-HSA-8852276;Reactome: R-HSA-5610783;Reactome: R-HSA-5689603;Reactome: R-HSA-68827;Reactome: R-HSA-5607764;Reactome: R-HSA-180534;Reactome: R-HSA-187577;Reactome: R-HSA-5668541;Reactome: R-HSA-350562;Reactome: R-HSA-8941858;Reactome: R-HSA-9010553;Reactome: R-HSA-1236974;Reactome: R-HSA-5610780;Reactome: R-HSA-450408;Reactome: R-HSA-5632684;Reactome: R-HSA-4641258;Reactome: R-HSA-211733;Reactome: R-HSA-382556;Reactome: R-HSA-68949;Reactome: R-HSA-1169091;Reactome: R-HSA-2871837;Reactome: R-HSA-174178;Reactome: R-HSA-195253;Reactome: R-HSA-5358346;Reactome: R-HSA-69017;Reactome: R-HSA-69601;Reactome: R-HSA-5676590;Reactome: R-HSA-9604323;Reactome: R-HSA-5362768	"Cross-presentation of soluble exogenous antigens (endosomes)";"Asymmetric localization of PCP proteins";"Degradation of AXIN";"Ubiquitin-dependent degradation of Cyclin D";"Downstream TCR signaling";"Autodegradation of Cdh1 by Cdh1:APC/C";"Ub-specific processing proteases";"Neddylation";"Autodegradation of the E3 ubiquitin ligase COP1";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Defective CFTR causes cystic fibrosis";"Vif-mediated degradation of APOBEC3G";"GLI3 is processed to GLI3R by the proteasome";"Neutrophil degranulation";"Dectin-1 mediated noncanonical NF-kB signaling";"Regulation of RAS by GAPs";"Antigen processing: Ubiquitination & Proteasome degradation";"Separation of Sister Chromatids";"APC/C:Cdc20 mediated degradation of Securin";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Regulation of RUNX2 expression and activity";"SCF-beta-TrCP mediated degradation of Emi1";"MAPK6/MAPK4 signaling";"Interleukin-1 signaling";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of PTEN stability and activity";"G2/M Checkpoints";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Degradation of GLI2 by the proteasome";"UCH proteinases";"CDT1 association with the CDC6:ORC:origin complex";"CLEC7A (Dectin-1) signaling";"Vpu mediated degradation of CD4";"SCF(Skp2)-mediated degradation of p27/p21";"TNFR2 non-canonical NF-kB pathway";"Regulation of ornithine decarboxylase (ODC)";"Regulation of RUNX3 expression and activity";"Regulation of expression of SLITs and ROBOs";"ER-Phagosome pathway";"Degradation of GLI1 by the proteasome";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Hedgehog 'on' state";"Degradation of DVL";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"ABC-family proteins mediated transport";"Orc1 removal from chromatin";"Activation of NF-kappaB in B cells";"FCERI mediated NF-kB activation";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Degradation of beta-catenin by the destruction complex";"Hedgehog ligand biogenesis";"CDK-mediated phosphorylation and removal of Cdc6";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"NIK-->noncanonical NF-kB signaling";"Negative regulation of NOTCH4 signaling";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD"
XP_046419571.1	7	Reactome: R-HSA-9013507;Reactome: R-HSA-2644606;Reactome: R-HSA-2894862;Reactome: R-HSA-2122948;MetaCyc: PWY-7511;Reactome: R-HSA-2691232;Reactome: R-HSA-2979096	"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Activated NOTCH1 Transmits Signal to the Nucleus";"Protein ubiquitination";"Constitutive Signaling by NOTCH1 HD Domain Mutants";"NOTCH2 Activation and Transmission of Signal to the Nucleus"
XP_046432996.1	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276	"Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination"
XP_046423260.1	17	KEGG: 00620+6.4.1.2;Reactome: R-HSA-163765;MetaCyc: PWY-5744;MetaCyc: PWY-6722;KEGG: 00254+6.4.1.2;MetaCyc: PWY-6679;Reactome: R-HSA-2426168;MetaCyc: PWY-5743;KEGG: 00720+6.4.1.2;MetaCyc: PWY-4381;MetaCyc: PWY-5789;KEGG: 00061+6.4.1.2;Reactome: R-HSA-3371599;KEGG: 00640+6.4.1.2;Reactome: R-HSA-200425;MetaCyc: PWY-5966-1;Reactome: R-HSA-196780	"Pyruvate metabolism";"ChREBP activates metabolic gene expression";"Glyoxylate assimilation";"Candicidin biosynthesis";"Aflatoxin biosynthesis";"Jadomycin biosynthesis";"Activation of gene expression by SREBF (SREBP)";"3-hydroxypropanoate cycle";"Carbon fixation pathways in prokaryotes";"Fatty acid biosynthesis initiation (bacteria and plants)";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Fatty acid biosynthesis";"Defective HLCS causes multiple carboxylase deficiency";"Propanoate metabolism";"Carnitine metabolism";"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)";"Biotin transport and metabolism"
XP_046415008.1	7	KEGG: 00220+3.5.1.2;Reactome: R-HSA-8964539;KEGG: 00471+3.5.1.2;Reactome: R-HSA-5628897;MetaCyc: PWY-5921;KEGG: 00250+3.5.1.2;Reactome: R-HSA-210500	"Arginine biosynthesis";"Glutamate and glutamine metabolism";"D-Glutamine and D-glutamate metabolism";"TP53 Regulates Metabolic Genes";"Glutaminyl-trnagln biosynthesis via transamidation";"Alanine, aspartate and glutamate metabolism";"Glutamate Neurotransmitter Release Cycle"
XP_046424878.1	2	Reactome: R-HSA-5693568;Reactome: R-HSA-6783310	"Resolution of D-loop Structures through Holliday Junction Intermediates";"Fanconi Anemia Pathway"
XP_046418788.1	2	Reactome: R-HSA-983168;Reactome: R-HSA-6798695	"Antigen processing: Ubiquitination & Proteasome degradation";"Neutrophil degranulation"
XP_046421017.1	6	MetaCyc: PWY-7656;KEGG: 00073+1.2.1.84;Reactome: R-HSA-9640463;MetaCyc: PWY-6733;MetaCyc: PWY-5884;MetaCyc: PWY-7782	"Spodoptera littoralis pheromone biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax biosynthesis";"Sporopollenin precursors biosynthesis";"Wax esters biosynthesis I";"Plasmalogen biosynthesis"
XP_046427533.1	1	Reactome: R-HSA-1632852	"Macroautophagy"
XP_046416115.1	16	Reactome: R-HSA-156902;Reactome: R-HSA-72764;Reactome: R-HSA-72649;Reactome: R-HSA-975957;Reactome: R-HSA-72695;Reactome: R-HSA-1799339;Reactome: R-HSA-72689;Reactome: R-HSA-192823;Reactome: R-HSA-72702;Reactome: R-HSA-975956;Reactome: R-HSA-6791226;Reactome: R-HSA-2408557;Reactome: R-HSA-72706;Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-9010553	"Peptide chain elongation";"Eukaryotic Translation Termination";"Translation initiation complex formation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Formation of the ternary complex, and subsequently, the 43S complex";"SRP-dependent cotranslational protein targeting to membrane";"Formation of a pool of free 40S subunits";"Viral mRNA Translation";"Ribosomal scanning and start codon recognition";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"Selenocysteine synthesis";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs"
XP_046433814.1	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
XP_046436107.1	2	Reactome: R-HSA-379726;KEGG: 00970+6.1.1.2	"Mitochondrial tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis"
XP_046427071.1	20	Reactome: R-HSA-8943724;Reactome: R-HSA-380972;Reactome: R-HSA-5674400;Reactome: R-HSA-165159;Reactome: R-HSA-6804757;Reactome: R-HSA-1257604;Reactome: R-HSA-1632852;Reactome: R-HSA-5218920;KEGG: 05165+2.7.11.1;Reactome: R-HSA-5628897;KEGG: 04151+2.7.11.1;Reactome: R-HSA-9639288;KEGG: 04150+2.7.11.1;KEGG: 05163+2.7.11.1;Reactome: R-HSA-3371571;KEGG: 04926+2.7.11.1;Reactome: R-HSA-389357;KEGG: 04714+2.7.11.1;Reactome: R-HSA-166208;KEGG: 05170+2.7.11.1	"Regulation of PTEN gene transcription";"Energy dependent regulation of mTOR by LKB1-AMPK";"Constitutive Signaling by AKT1 E17K in Cancer";"mTOR signalling";"Regulation of TP53 Degradation";"PIP3 activates AKT signaling";"Macroautophagy";"VEGFR2 mediated vascular permeability";"Human papillomavirus infection";"TP53 Regulates Metabolic Genes";"PI3K-Akt signaling pathway";"Amino acids regulate mTORC1";"mTOR signaling pathway";"Human cytomegalovirus infection";"HSF1-dependent transactivation";"Relaxin signaling pathway";"CD28 dependent PI3K/Akt signaling";"Thermogenesis";"mTORC1-mediated signalling";"Human immunodeficiency virus 1 infection"
XP_046434704.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_046419835.1	5	KEGG: 00520+2.6.1.16;Reactome: R-HSA-446210;KEGG: 00250+2.6.1.16;MetaCyc: PWY-8013;MetaCyc: PWY-6749	"Amino sugar and nucleotide sugar metabolism";"Synthesis of UDP-N-acetyl-glucosamine";"Alanine, aspartate and glutamate metabolism";"UDP-N-acetyl-D-galactosamine biosynthesis III";"CMP-legionaminate biosynthesis I"
XP_046430877.1	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
XP_046432978.1	1	Reactome: R-HSA-110362	"POLB-Dependent Long Patch Base Excision Repair"
XP_046418416.1	2	Reactome: R-HSA-6796648;Reactome: R-HSA-6783310	"TP53 Regulates Transcription of DNA Repair Genes";"Fanconi Anemia Pathway"
XP_046435098.1	4	Reactome: R-HSA-5661270;MetaCyc: PWY-4261;KEGG: 00040+2.7.1.17;KEGG: 00561+2.7.1.30	"Formation of xylulose-5-phosphate";"Glycerol degradation I";"Pentose and glucuronate interconversions";"Glycerolipid metabolism"
XP_046431469.1	7	KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1	"Human cytomegalovirus infection";"Thermogenesis";"Relaxin signaling pathway";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"PI3K-Akt signaling pathway";"mTOR signaling pathway"
XP_046429828.1	8	KEGG: 00524+2.7.1.1;KEGG: 00052+2.7.1.1;KEGG: 00500+2.7.1.1;KEGG: 00520+2.7.1.1;KEGG: 00010+2.7.1.1;KEGG: 00051+2.7.1.1;Reactome: R-HSA-70171;KEGG: 00521+2.7.1.1	"Neomycin, kanamycin and gentamicin biosynthesis";"Galactose metabolism";"Starch and sucrose metabolism";"Amino sugar and nucleotide sugar metabolism";"Glycolysis / Gluconeogenesis";"Fructose and mannose metabolism";"Glycolysis";"Streptomycin biosynthesis"
XP_046415251.1	8	MetaCyc: PWY-7221;Reactome: R-HSA-9609736;Reactome: R-HSA-442982;Reactome: R-HSA-9617324;Reactome: R-HSA-438066;Reactome: R-HSA-9620244;KEGG: 00230+2.7.4.8;Reactome: R-HSA-5673001	"Guanosine ribonucleotides de novo biosynthesis";"Assembly and cell surface presentation of NMDA receptors";"Ras activation upon Ca2+ influx through NMDA receptor";"Negative regulation of NMDA receptor-mediated neuronal transmission";"Unblocking of NMDA receptors, glutamate binding and activation";"Long-term potentiation";"Purine metabolism";"RAF/MAP kinase cascade"
XP_046429086.1	13	MetaCyc: PWY-7182;MetaCyc: PWY-7410;MetaCyc: PWY-7102;MetaCyc: PWY-6859;MetaCyc: PWY-5123;MetaCyc: PWY-7736;MetaCyc: PWY-7709;MetaCyc: PWY-6383;MetaCyc: PWY-7659;KEGG: 00900+2.5.1.10+2.5.1.1;MetaCyc: PWY-7141;MetaCyc: PWY-7721;MetaCyc: PWY-5122	"Linalool biosynthesis I";"Ipsdienol biosynthesis";"Bisabolene biosynthesis (engineered)";"All-trans-farnesol biosynthesis";"Trans, trans-farnesyl diphosphate biosynthesis";"Stellatic acid biosynthesis";"(3R)-linalool biosynthesis";"Mono-trans, poly-cis decaprenyl phosphate biosynthesis";"Viridicatumtoxin biosynthesis";"Terpenoid backbone biosynthesis";"(3S)-linalool biosynthesis";"Methyl phomopsenoate biosynthesis";"Geranyl diphosphate biosynthesis"
XP_046421391.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046418961.1	1	Reactome: R-HSA-200425	"Carnitine metabolism"
XP_046421545.1	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276	"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination"
XP_046431494.1	3	Reactome: R-HSA-379716;KEGG: 00970+6.1.1.19;Reactome: R-HSA-2408522	"Cytosolic tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis";"Selenoamino acid metabolism"
XP_046411635.1	7	KEGG: 00600+2.4.1.80;MetaCyc: PWY-5129;MetaCyc: PWY-7836;Reactome: R-HSA-1660662;MetaCyc: PWY-7841;MetaCyc: PWY-7838;MetaCyc: PWY-7839	"Sphingolipid metabolism";"Sphingolipid biosynthesis (plants)";"Ganglio-series glycosphingolipids biosynthesis";"Glycosphingolipid metabolism";"Neolacto-series glycosphingolipids biosynthesis";"Globo-series glycosphingolipids biosynthesis";"Lacto-series glycosphingolipids biosynthesis"
XP_046419226.1	3	Reactome: R-HSA-5655862;Reactome: R-HSA-110312;Reactome: R-HSA-5656121	"Translesion synthesis by POLK";"Translesion synthesis by REV1";"Translesion synthesis by POLI"
XP_046435325.1	2	Reactome: R-HSA-8951664;Reactome: R-HSA-983168	"Neddylation";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046421169.1	9	KEGG: 00564+1.1.1.94;KEGG: 00564+1.1.1.8;MetaCyc: PWY-5981;MetaCyc: PWY-7385;MetaCyc: PWY-6118;MetaCyc: PWY-7411;Reactome: R-HSA-1483166;MetaCyc: PWY-5667;MetaCyc: PWY-7902	"Glycerophospholipid metabolism";"Glycerophospholipid metabolism";"CDP-diacylglycerol biosynthesis III";"1,3-propanediol biosynthesis (engineered)";"Glycerol-3-phosphate shuttle";"Phosphatidate biosynthesis (yeast)";"Synthesis of PA";"CDP-diacylglycerol biosynthesis I";"Glucosylglycerol biosynthesis"
XP_046418324.1	7	Reactome: R-HSA-156711;Reactome: R-HSA-1362300;Reactome: R-HSA-69202;Reactome: R-HSA-1538133;Reactome: R-HSA-69656;Reactome: R-HSA-1362277;Reactome: R-HSA-69205	"Polo-like kinase mediated events";"Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1";"Cyclin E associated events during G1/S transition";"G0 and Early G1";"Cyclin A:Cdk2-associated events at S phase entry";"Transcription of E2F targets under negative control by DREAM complex";"G1/S-Specific Transcription"
XP_046411612.1	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276	"Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination"
XP_046421973.1	2	Reactome: R-HSA-1296052;Reactome: R-HSA-418457	"Ca2+ activated K+ channels";"cGMP effects"
XP_046412587.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_046426655.1	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
XP_046434980.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046433556.1	4	Reactome: R-HSA-8874081;Reactome: R-HSA-3000171;Reactome: R-HSA-3000178;Reactome: R-HSA-3000157	"MET activates PTK2 signaling";"Non-integrin membrane-ECM interactions";"ECM proteoglycans";"Laminin interactions"
XP_046426569.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046435246.1	3	KEGG: 00740+3.1.3.2;MetaCyc: PWY-6348;KEGG: 00730+3.1.3.2	"Riboflavin metabolism";"Phosphate acquisition";"Thiamine metabolism"
XP_046414140.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_046414956.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_046410691.1	1	Reactome: R-HSA-1474228	"Degradation of the extracellular matrix"
XP_046418717.1	3	Reactome: R-HSA-391160;KEGG: 04660+2.7.10.2;Reactome: R-HSA-4420097	"Signal regulatory protein family interactions";"T cell receptor signaling pathway";"VEGFA-VEGFR2 Pathway"
XP_046434295.1	6	Reactome: R-HSA-975634;Reactome: R-HSA-2453864;Reactome: R-HSA-3000171;Reactome: R-HSA-6798695;Reactome: R-HSA-2453902;Reactome: R-HSA-977225	"Retinoid metabolism and transport";"Retinoid cycle disease events";"Non-integrin membrane-ECM interactions";"Neutrophil degranulation";"The canonical retinoid cycle in rods (twilight vision)";"Amyloid fiber formation"
XP_046421632.1	3	KEGG: 04070+2.7.4.24+2.7.4.21;MetaCyc: PWY-6369;Reactome: R-HSA-1855167	"Phosphatidylinositol signaling system";"Inositol diphosphates biosynthesis";"Synthesis of pyrophosphates in the cytosol"
XP_046422334.1	1	Reactome: R-HSA-5663220	"RHO GTPases Activate Formins"
XP_046420932.1	11	KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;Reactome: R-HSA-163680;Reactome: R-HSA-6804756;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;Reactome: R-HSA-380972;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;Reactome: R-HSA-9614657	"mTOR signaling pathway";"PI3K-Akt signaling pathway";"AMPK inhibits chREBP transcriptional activation activity";"Regulation of TP53 Activity through Phosphorylation";"Relaxin signaling pathway";"Human cytomegalovirus infection";"Energy dependent regulation of mTOR by LKB1-AMPK";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Thermogenesis";"FOXO-mediated transcription of cell death genes"
XP_046409941.1	2	Reactome: R-HSA-71403;Reactome: R-HSA-611105	"Citric acid cycle (TCA cycle)";"Respiratory electron transport"
XP_046424999.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046417783.1	1	Reactome: R-HSA-2022377	"Metabolism of Angiotensinogen to Angiotensins"
XP_046423627.1	3	KEGG: 00531+3.2.1.50;Reactome: R-HSA-2024096;Reactome: R-HSA-2206282	"Glycosaminoglycan degradation";"HS-GAG degradation";"MPS IIIB - Sanfilippo syndrome B"
XP_046413891.1	6	Reactome: R-HSA-69052;Reactome: R-HSA-68962;Reactome: R-HSA-68949;Reactome: R-HSA-176974;Reactome: R-HSA-68867;Reactome: R-HSA-176187	"Switching of origins to a post-replicative state";"Activation of the pre-replicative complex";"Orc1 removal from chromatin";"Unwinding of DNA";"Assembly of the pre-replicative complex";"Activation of ATR in response to replication stress"
XP_046436328.1	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
XP_046418794.1	2	Reactome: R-HSA-983168;Reactome: R-HSA-6798695	"Antigen processing: Ubiquitination & Proteasome degradation";"Neutrophil degranulation"
XP_046426570.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046422294.1	1	Reactome: R-HSA-191273	"Cholesterol biosynthesis"
XP_046416185.1	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
XP_046416076.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046413139.1	8	Reactome: R-HSA-1855183;MetaCyc: PWY-6580;MetaCyc: PWY-6664;MetaCyc: PWY-2301;KEGG: 00521+5.5.1.4;MetaCyc: PWY-6372;MetaCyc: PWY-4661;KEGG: 00562+5.5.1.4	"Synthesis of IP2, IP, and Ins in the cytosol";"Phosphatidylinositol biosynthesis I (bacteria)";"Di-myo-inositol phosphate biosynthesis";"Myo-inositol biosynthesis";"Streptomycin biosynthesis";"1D-myo-inositol hexakisphosphate biosynthesis IV (Dictyostelium)";"1D-myo-inositol hexakisphosphate biosynthesis III (Spirodela polyrrhiza)";"Inositol phosphate metabolism"
XP_046409782.1	5	Reactome: R-HSA-6811440;Reactome: R-HSA-8856825;Reactome: R-HSA-6798695;Reactome: R-HSA-8856828;Reactome: R-HSA-432722	"Retrograde transport at the Trans-Golgi-Network";"Cargo recognition for clathrin-mediated endocytosis";"Neutrophil degranulation";"Clathrin-mediated endocytosis";"Golgi Associated Vesicle Biogenesis"
XP_046414198.1	1	Reactome: R-HSA-5620912	"Anchoring of the basal body to the plasma membrane"
XP_046431883.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046409609.1	2	Reactome: R-HSA-2132295;Reactome: R-HSA-877300	"MHC class II antigen presentation";"Interferon gamma signaling"
XP_046409942.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-71403	"Respiratory electron transport";"Citric acid cycle (TCA cycle)"
XP_046433563.1	3	Reactome: R-HSA-1358803;Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Downregulation of ERBB2:ERBB3 signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_046430979.1	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
XP_046413879.1	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_046417310.1	2	MetaCyc: PWY-7799;MetaCyc: PWY-7802	"Arg/N-end rule pathway (eukaryotic)";"N-end rule pathway II (prokaryotic)"
XP_046414138.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_046415951.1	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
XP_046409325.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_046418808.1	3	Reactome: R-HSA-72163;Reactome: R-HSA-5250924;Reactome: R-HSA-72165	"mRNA Splicing - Major Pathway";"B-WICH complex positively regulates rRNA expression";"mRNA Splicing - Minor Pathway"
XP_046422065.1	1	Reactome: R-HSA-140342	"Apoptosis induced DNA fragmentation"
XP_046432314.1	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276	"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination"
XP_046413615.1	1	Reactome: R-HSA-6809371	"Formation of the cornified envelope"
XP_046422240.1	1	Reactome: R-HSA-606279	"Deposition of new CENPA-containing nucleosomes at the centromere"
XP_046411062.1	2	Reactome: R-HSA-1632852;Reactome: R-HSA-5689880	"Macroautophagy";"Ub-specific processing proteases"
XP_046420306.1	15	Reactome: R-HSA-3769402;Reactome: R-HSA-4641262;Reactome: R-HSA-5358747;Reactome: R-HSA-111465;Reactome: R-HSA-5467340;Reactome: R-HSA-5339716;Reactome: R-HSA-195253;Reactome: R-HSA-5358752;Reactome: R-HSA-5467333;Reactome: R-HSA-5358751;Reactome: R-HSA-5467348;Reactome: R-HSA-5467337;Reactome: R-HSA-196299;Reactome: R-HSA-5358749;Reactome: R-HSA-5689896	"Deactivation of the beta-catenin transactivating complex";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"S33 mutants of beta-catenin aren't phosphorylated";"Apoptotic cleavage of cellular proteins";"AXIN missense mutants destabilize the destruction complex";"Misspliced GSK3beta mutants stabilize beta-catenin";"Degradation of beta-catenin by the destruction complex";"T41 mutants of beta-catenin aren't phosphorylated";"APC truncation mutants are not K63 polyubiquitinated";"S45 mutants of beta-catenin aren't phosphorylated";"Truncations of AMER1 destabilize the destruction complex";"APC truncation mutants have impaired AXIN binding";"Beta-catenin phosphorylation cascade";"S37 mutants of beta-catenin aren't phosphorylated";"Ovarian tumor domain proteases"
XP_046433714.1	2	Reactome: R-HSA-8949215;Reactome: R-HSA-8949664	"Mitochondrial calcium ion transport";"Processing of SMDT1"
XP_046427332.1	2	MetaCyc: PWY-6502;Reactome: R-HSA-2393930	"8-oxo-(d)GTP detoxification I";"Phosphate bond hydrolysis by NUDT proteins"
XP_046429943.1	3	Reactome: R-HSA-5173105;Reactome: R-HSA-5083627;Reactome: R-HSA-2022854	"O-linked glycosylation";"Defective LARGE causes MDDGA6 and MDDGB6";"Keratan sulfate biosynthesis"
XP_046425100.1	11	Reactome: R-HSA-1368108;Reactome: R-HSA-2426168;Reactome: R-HSA-2151201;Reactome: R-HSA-381340;Reactome: R-HSA-3214858;Reactome: R-HSA-400206;Reactome: R-HSA-9018519;Reactome: R-HSA-1368082;Reactome: R-HSA-400253;Reactome: R-HSA-6804114;Reactome: R-HSA-1989781	"BMAL1:CLOCK,NPAS2 activates circadian gene expression";"Activation of gene expression by SREBF (SREBP)";"Transcriptional activation of mitochondrial biogenesis";"Transcriptional regulation of white adipocyte differentiation";"RMTs methylate histone arginines";"Regulation of lipid metabolism by PPARalpha";"Estrogen-dependent gene expression";"RORA activates gene expression";"Circadian Clock";"TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest";"PPARA activates gene expression"
XP_046413850.1	2	Reactome: R-HSA-3238698;Reactome: R-HSA-373080	"WNT ligand biogenesis and trafficking";"Class B/2 (Secretin family receptors)"
XP_046430472.1	4	Reactome: R-HSA-3769402;Reactome: R-HSA-201722;Reactome: R-HSA-2122947;Reactome: R-HSA-4641265	"Deactivation of the beta-catenin transactivating complex";"Formation of the beta-catenin:TCF transactivating complex";"NOTCH1 Intracellular Domain Regulates Transcription";"Repression of WNT target genes"
XP_046409618.1	5	KEGG: 00564+2.7.7.41;MetaCyc: PWY-7817;MetaCyc: PWY-5667;MetaCyc: PWY-5981;KEGG: 04070+2.7.7.41	"Glycerophospholipid metabolism";"Type I lipoteichoic acid biosynthesis (S. aureus)";"CDP-diacylglycerol biosynthesis I";"CDP-diacylglycerol biosynthesis III";"Phosphatidylinositol signaling system"
XP_046424728.1	4	Reactome: R-HSA-6798163;KEGG: 00260+1.2.1.8+1.1.99.1;MetaCyc: PWY-3722;MetaCyc: PWY-7494	"Choline catabolism";"Glycine, serine and threonine metabolism";"Glycine betaine biosynthesis II (Gram-positive bacteria)";"Choline degradation IV"
XP_046426423.1	9	Reactome: R-HSA-5689880;Reactome: R-HSA-9613829;Reactome: R-HSA-9615710;Reactome: R-HSA-8856825;Reactome: R-HSA-8856828;Reactome: R-HSA-5678895;Reactome: R-HSA-9646399;Reactome: R-HSA-5627083;Reactome: R-HSA-382556	"Ub-specific processing proteases";"Chaperone Mediated Autophagy";"Late endosomal microautophagy";"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis";"Defective CFTR causes cystic fibrosis";"Aggrephagy";"RHO GTPases regulate CFTR trafficking";"ABC-family proteins mediated transport"
XP_046425428.1	2	Reactome: R-HSA-416476;Reactome: R-HSA-375280	"G alpha (q) signalling events";"Amine ligand-binding receptors"
XP_046427369.1	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
XP_046434860.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-5628897	"Respiratory electron transport";"TP53 Regulates Metabolic Genes"
XP_046436624.1	1	Reactome: R-HSA-2428928	"IRS-related events triggered by IGF1R"
XP_046432729.1	9	Reactome: R-HSA-5693568;Reactome: R-HSA-5693607;Reactome: R-HSA-5685942;Reactome: R-HSA-5693579;Reactome: R-HSA-69473;Reactome: R-HSA-6804756;Reactome: R-HSA-5693616;Reactome: R-HSA-5693554;Reactome: R-HSA-5685938	"Resolution of D-loop Structures through Holliday Junction Intermediates";"Processing of DNA double-strand break ends";"HDR through Homologous Recombination (HRR)";"Homologous DNA Pairing and Strand Exchange";"G2/M DNA damage checkpoint";"Regulation of TP53 Activity through Phosphorylation";"Presynaptic phase of homologous DNA pairing and strand exchange";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"HDR through Single Strand Annealing (SSA)"
XP_046421616.1	3	KEGG: 04070+2.7.4.24+2.7.4.21;MetaCyc: PWY-6369;Reactome: R-HSA-1855167	"Phosphatidylinositol signaling system";"Inositol diphosphates biosynthesis";"Synthesis of pyrophosphates in the cytosol"
XP_046409943.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-71403	"Respiratory electron transport";"Citric acid cycle (TCA cycle)"
XP_046423929.1	6	Reactome: R-HSA-9640463;MetaCyc: PWY-6733;MetaCyc: PWY-7656;KEGG: 00073+1.2.1.84;MetaCyc: PWY-7782;MetaCyc: PWY-5884	"Wax biosynthesis";"Sporopollenin precursors biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Cutin, suberine and wax biosynthesis";"Plasmalogen biosynthesis";"Wax esters biosynthesis I"
XP_046426505.1	7	KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1	"Human cytomegalovirus infection";"Thermogenesis";"Relaxin signaling pathway";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"mTOR signaling pathway"
XP_046435581.1	6	KEGG: 00520+2.7.7.12;MetaCyc: PWY-6527;Reactome: R-HSA-5609978;KEGG: 00052+2.7.7.12;MetaCyc: PWY-6317;Reactome: R-HSA-70370	"Amino sugar and nucleotide sugar metabolism";"Stachyose degradation";"Defective GALT can cause Galactosemia";"Galactose metabolism";"D-galactose degradation I (Leloir pathway)";"Galactose catabolism"
XP_046429473.1	1	Reactome: R-HSA-419771	"Opsins"
XP_046411957.1	1	KEGG: 00480+3.4.11.2	"Glutathione metabolism"
XP_046419921.1	19	Reactome: R-HSA-6802955;Reactome: R-HSA-9649948;Reactome: R-HSA-6802952;Reactome: R-HSA-3371571;Reactome: R-HSA-442982;Reactome: R-HSA-9620244;Reactome: R-HSA-6802946;Reactome: R-HSA-5673000;Reactome: R-HSA-5673001;Reactome: R-HSA-399719;Reactome: R-HSA-5578775;Reactome: R-HSA-936837;Reactome: R-HSA-9609736;Reactome: R-HSA-9617324;Reactome: R-HSA-5576892;Reactome: R-HSA-877300;Reactome: R-HSA-111932;Reactome: R-HSA-9022692;Reactome: R-HSA-438066	"Paradoxical activation of RAF signaling by kinase inactive BRAF";"Signaling downstream of RAS mutants";"Signaling by BRAF and RAF fusions";"HSF1-dependent transactivation";"Ras activation upon Ca2+ influx through NMDA receptor";"Long-term potentiation";"Signaling by moderate kinase activity BRAF mutants";"RAF activation";"RAF/MAP kinase cascade";"Trafficking of AMPA receptors";"Ion homeostasis";"Ion transport by P-type ATPases";"Assembly and cell surface presentation of NMDA receptors";"Negative regulation of NMDA receptor-mediated neuronal transmission";"Phase 0 - rapid depolarisation";"Interferon gamma signaling";"CaMK IV-mediated phosphorylation of CREB";"Regulation of MECP2 expression and activity";"Unblocking of NMDA receptors, glutamate binding and activation"
XP_046422536.1	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
XP_046415407.1	2	Reactome: R-HSA-6811434;Reactome: R-HSA-6807878	"COPI-dependent Golgi-to-ER retrograde traffic";"COPI-mediated anterograde transport"
XP_046427487.1	2	Reactome: R-HSA-5576893;Reactome: R-HSA-5576892	"Phase 2 - plateau phase";"Phase 0 - rapid depolarisation"
XP_046423133.1	3	Reactome: R-HSA-6785470;Reactome: R-HSA-6784531;Reactome: R-HSA-8868766	"tRNA processing in the mitochondrion";"tRNA processing in the nucleus";"rRNA processing in the mitochondrion"
XP_046419227.1	3	Reactome: R-HSA-5656121;Reactome: R-HSA-110312;Reactome: R-HSA-5655862	"Translesion synthesis by POLI";"Translesion synthesis by REV1";"Translesion synthesis by POLK"
XP_046434294.1	6	Reactome: R-HSA-2453902;Reactome: R-HSA-977225;Reactome: R-HSA-6798695;Reactome: R-HSA-3000171;Reactome: R-HSA-2453864;Reactome: R-HSA-975634	"The canonical retinoid cycle in rods (twilight vision)";"Amyloid fiber formation";"Neutrophil degranulation";"Non-integrin membrane-ECM interactions";"Retinoid cycle disease events";"Retinoid metabolism and transport"
XP_046413291.1	4	Reactome: R-HSA-4641257;Reactome: R-HSA-5689880;Reactome: R-HSA-201681;Reactome: R-HSA-418594	"Degradation of AXIN";"Ub-specific processing proteases";"TCF dependent signaling in response to WNT";"G alpha (i) signalling events"
XP_046429531.1	2	Reactome: R-HSA-8876198;Reactome: R-HSA-5357905	"RAB GEFs exchange GTP for GDP on RABs";"Regulation of TNFR1 signaling"
XP_046425917.1	2	Reactome: R-HSA-5693568;Reactome: R-HSA-6783310	"Resolution of D-loop Structures through Holliday Junction Intermediates";"Fanconi Anemia Pathway"
XP_046417791.1	1	Reactome: R-HSA-442660	"Na+/Cl- dependent neurotransmitter transporters"
XP_046418841.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_046431395.1	27	Reactome: R-HSA-5358751;KEGG: 04926+2.7.11.1;Reactome: R-HSA-195253;Reactome: R-HSA-5358752;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;Reactome: R-HSA-8939902;Reactome: R-HSA-5358747;Reactome: R-HSA-5467340;Reactome: R-HSA-198323;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;Reactome: R-HSA-3371453;Reactome: R-HSA-5250924;Reactome: R-HSA-5610783;Reactome: R-HSA-4641262;Reactome: R-HSA-5339716;Reactome: R-HSA-5610785;KEGG: 05165+2.7.11.1;Reactome: R-HSA-5358749;Reactome: R-HSA-75815;Reactome: R-HSA-399956;Reactome: R-HSA-196299;Reactome: R-HSA-5467337;Reactome: R-HSA-5674400;Reactome: R-HSA-5467348	"S45 mutants of beta-catenin aren't phosphorylated";"Relaxin signaling pathway";"Degradation of beta-catenin by the destruction complex";"T41 mutants of beta-catenin aren't phosphorylated";"Human cytomegalovirus infection";"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Regulation of RUNX2 expression and activity";"S33 mutants of beta-catenin aren't phosphorylated";"AXIN missense mutants destabilize the destruction complex";"AKT phosphorylates targets in the cytosol";"Human immunodeficiency virus 1 infection";"Thermogenesis";"Regulation of HSF1-mediated heat shock response";"B-WICH complex positively regulates rRNA expression";"Degradation of GLI2 by the proteasome";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"Misspliced GSK3beta mutants stabilize beta-catenin";"GLI3 is processed to GLI3R by the proteasome";"Human papillomavirus infection";"S37 mutants of beta-catenin aren't phosphorylated";"Ubiquitin-dependent degradation of Cyclin D";"CRMPs in Sema3A signaling";"Beta-catenin phosphorylation cascade";"APC truncation mutants have impaired AXIN binding";"Constitutive Signaling by AKT1 E17K in Cancer";"Truncations of AMER1 destabilize the destruction complex"
XP_046434229.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_046427281.1	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
XP_046436565.1	9	Reactome: R-HSA-3304356;Reactome: R-HSA-3656535;Reactome: R-HSA-3642279;Reactome: R-HSA-2173788;Reactome: R-HSA-3645790;Reactome: R-HSA-3656532;Reactome: R-HSA-2173791;Reactome: R-HSA-2173789;Reactome: R-HSA-5689603	"SMAD2/3 Phosphorylation Motif Mutants in Cancer";"TGFBR1 LBD Mutants in Cancer";"TGFBR2 MSI Frameshift Mutants in Cancer";"Downregulation of TGF-beta receptor signaling";"TGFBR2 Kinase Domain Mutants in Cancer";"TGFBR1 KD Mutants in Cancer";"TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)";"TGF-beta receptor signaling activates SMADs";"UCH proteinases"
XP_046427993.1	3	Reactome: R-HSA-193648;Reactome: R-HSA-416482;Reactome: R-HSA-194840	"NRAGE signals death through JNK";"G alpha (12/13) signalling events";"Rho GTPase cycle"
XP_046430471.1	4	Reactome: R-HSA-201722;Reactome: R-HSA-2122947;Reactome: R-HSA-4641265;Reactome: R-HSA-3769402	"Formation of the beta-catenin:TCF transactivating complex";"NOTCH1 Intracellular Domain Regulates Transcription";"Repression of WNT target genes";"Deactivation of the beta-catenin transactivating complex"
XP_046416447.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-5628897	"Respiratory electron transport";"TP53 Regulates Metabolic Genes"
XP_046420056.1	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
XP_046414562.1	1	Reactome: R-HSA-1660661	"Sphingolipid de novo biosynthesis"
XP_046429138.1	16	Reactome: R-HSA-194840;Reactome: R-HSA-1433557;Reactome: R-HSA-912526;Reactome: R-HSA-114604;Reactome: R-HSA-1660499;Reactome: R-HSA-6811558;Reactome: R-HSA-8853659;Reactome: R-HSA-416476;Reactome: R-HSA-389357;Reactome: R-HSA-388841;Reactome: R-HSA-1257604;Reactome: R-HSA-512988;Reactome: R-HSA-2219530;Reactome: R-HSA-1266695;Reactome: R-HSA-9009391;Reactome: R-HSA-912631	"Rho GTPase cycle";"Signaling by SCF-KIT";"Interleukin receptor SHC signaling";"GPVI-mediated activation cascade";"Synthesis of PIPs at the plasma membrane";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"RET signaling";"G alpha (q) signalling events";"CD28 dependent PI3K/Akt signaling";"Costimulation by the CD28 family";"PIP3 activates AKT signaling";"Interleukin-3, Interleukin-5 and GM-CSF signaling";"Constitutive Signaling by Aberrant PI3K in Cancer";"Interleukin-7 signaling";"Extra-nuclear estrogen signaling";"Regulation of signaling by CBL"
XP_046432708.1	2	Reactome: R-HSA-69273;Reactome: R-HSA-8862803	"Cyclin A/B1/B2 associated events during G2/M transition";"Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models"
XP_046435073.1	7	KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1	"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Human cytomegalovirus infection";"Thermogenesis";"Relaxin signaling pathway";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection"
XP_046423336.1	2	Reactome: R-HSA-180024;KEGG: 00230+3.1.4.53	"DARPP-32 events";"Purine metabolism"
XP_046414772.1	8	Reactome: R-HSA-6804757;Reactome: R-HSA-6781823;Reactome: R-HSA-5689880;Reactome: R-HSA-6782210;Reactome: R-HSA-6782135;Reactome: R-HSA-6781827;Reactome: R-HSA-8948747;Reactome: R-HSA-8866652	"Regulation of TP53 Degradation";"Formation of TC-NER Pre-Incision Complex";"Ub-specific processing proteases";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Dual incision in TC-NER";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Regulation of PTEN localization";"Synthesis of active ubiquitin: roles of E1 and E2 enzymes"
XP_046414334.1	6	Reactome: R-HSA-176974;Reactome: R-HSA-68867;Reactome: R-HSA-176187;Reactome: R-HSA-68962;Reactome: R-HSA-68949;Reactome: R-HSA-69052	"Unwinding of DNA";"Assembly of the pre-replicative complex";"Activation of ATR in response to replication stress";"Activation of the pre-replicative complex";"Orc1 removal from chromatin";"Switching of origins to a post-replicative state"
XP_046433992.1	14	MetaCyc: PWY-7724;MetaCyc: PWY-5972;Reactome: R-HSA-75876;MetaCyc: PWY-6433;MetaCyc: PWY-8041;MetaCyc: PWY-6598;MetaCyc: PWY-7602;MetaCyc: PWY-7036;MetaCyc: PWY-7035;MetaCyc: PWY-7619;MetaCyc: PWY-7725;MetaCyc: PWY-5080;MetaCyc: PWY-7601;KEGG: 00062+2.3.1.199	"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Stearate biosynthesis I (animals)";"Synthesis of very long-chain fatty acyl-CoAs";"Hydroxylated fatty acid biosynthesis (plants)";"Ultra-long-chain fatty acid biosynthesis";"Sciadonate biosynthesis";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis II";"(9Z)-tricosene biosynthesis";"Juniperonate biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Very long chain fatty acid biosynthesis I";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Fatty acid elongation"
XP_046412326.1	56	Reactome: R-HSA-5607761;Reactome: R-HSA-983168;Reactome: R-HSA-5658442;Reactome: R-HSA-174154;Reactome: R-HSA-174184;Reactome: R-HSA-8939902;Reactome: R-HSA-2467813;Reactome: R-HSA-8951664;Reactome: R-HSA-5689880;Reactome: R-HSA-174084;Reactome: R-HSA-349425;Reactome: R-HSA-1236978;Reactome: R-HSA-4608870;Reactome: R-HSA-4641257;Reactome: R-HSA-202424;Reactome: R-HSA-75815;Reactome: R-HSA-180585;Reactome: R-HSA-5678895;Reactome: R-HSA-5610785;Reactome: R-HSA-8939236;Reactome: R-HSA-1236974;Reactome: R-HSA-450408;Reactome: R-HSA-5610780;Reactome: R-HSA-5632684;Reactome: R-HSA-4641258;Reactome: R-HSA-211733;Reactome: R-HSA-5668541;Reactome: R-HSA-8941858;Reactome: R-HSA-350562;Reactome: R-HSA-9010553;Reactome: R-HSA-69601;Reactome: R-HSA-69017;Reactome: R-HSA-5358346;Reactome: R-HSA-5362768;Reactome: R-HSA-5676590;Reactome: R-HSA-9604323;Reactome: R-HSA-1169091;Reactome: R-HSA-68949;Reactome: R-HSA-382556;Reactome: R-HSA-174178;Reactome: R-HSA-2871837;Reactome: R-HSA-195253;Reactome: R-HSA-8854050;Reactome: R-HSA-9020702;Reactome: R-HSA-174113;Reactome: R-HSA-5687128;Reactome: R-HSA-5689603;Reactome: R-HSA-68827;Reactome: R-HSA-5607764;Reactome: R-HSA-180534;Reactome: R-HSA-187577;Reactome: R-HSA-8948751;Reactome: R-HSA-1234176;Reactome: R-HSA-69481;Reactome: R-HSA-8852276;Reactome: R-HSA-5610783	"Dectin-1 mediated noncanonical NF-kB signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Regulation of RAS by GAPs";"APC/C:Cdc20 mediated degradation of Securin";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Regulation of RUNX2 expression and activity";"Separation of Sister Chromatids";"Neddylation";"Ub-specific processing proteases";"Autodegradation of Cdh1 by Cdh1:APC/C";"Autodegradation of the E3 ubiquitin ligase COP1";"Cross-presentation of soluble exogenous antigens (endosomes)";"Asymmetric localization of PCP proteins";"Degradation of AXIN";"Downstream TCR signaling";"Ubiquitin-dependent degradation of Cyclin D";"Vif-mediated degradation of APOBEC3G";"Defective CFTR causes cystic fibrosis";"GLI3 is processed to GLI3R by the proteasome";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"ER-Phagosome pathway";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Degradation of GLI1 by the proteasome";"Hedgehog 'on' state";"Degradation of DVL";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"TNFR2 non-canonical NF-kB pathway";"Regulation of RUNX3 expression and activity";"Regulation of ornithine decarboxylase (ODC)";"Regulation of expression of SLITs and ROBOs";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"CDK-mediated phosphorylation and removal of Cdc6";"Hedgehog ligand biogenesis";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"NIK-->noncanonical NF-kB signaling";"Negative regulation of NOTCH4 signaling";"Activation of NF-kappaB in B cells";"Orc1 removal from chromatin";"ABC-family proteins mediated transport";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"FCERI mediated NF-kB activation";"Degradation of beta-catenin by the destruction complex";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Interleukin-1 signaling";"SCF-beta-TrCP mediated degradation of Emi1";"MAPK6/MAPK4 signaling";"UCH proteinases";"CDT1 association with the CDC6:ORC:origin complex";"CLEC7A (Dectin-1) signaling";"Vpu mediated degradation of CD4";"SCF(Skp2)-mediated degradation of p27/p21";"Regulation of PTEN stability and activity";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"G2/M Checkpoints";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Degradation of GLI2 by the proteasome"
XP_046435321.1	2	Reactome: R-HSA-8951664;Reactome: R-HSA-983168	"Neddylation";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046428372.1	2	MetaCyc: PWY-7221;KEGG: 00230+2.7.4.8	"Guanosine ribonucleotides de novo biosynthesis";"Purine metabolism"
XP_046432487.1	4	Reactome: R-HSA-189483;KEGG: 00860+1.14.14.18;Reactome: R-HSA-917937;MetaCyc: PWY-5874	"Heme degradation";"Porphyrin and chlorophyll metabolism";"Iron uptake and transport";"Heme degradation I"
XP_046415451.1	31	MetaCyc: PWY-5366;MetaCyc: PWY-6282;Reactome: R-HSA-75105;MetaCyc: PWY-8047;KEGG: 00061+1.1.1.100+2.3.1.85+4.2.1.59+2.3.1.39+2.3.1.41+3.1.2.14;MetaCyc: PWY-5973;MetaCyc: PWY-7723;MetaCyc: PWY-5147;MetaCyc: PWY-5989;MetaCyc: PWY-7746;MetaCyc: PWY-7858;Reactome: R-HSA-9029558;MetaCyc: PWY-6113;MetaCyc: PWY-5994;MetaCyc: PWY-5971;Reactome: R-HSA-163765;MetaCyc: PWY-7663;MetaCyc: PWY-6519;MetaCyc: PWY-5966-1;MetaCyc: PWY-7388;MetaCyc: PWY-4381;MetaCyc: PWY-6799;Reactome: R-HSA-2426168;Reactome: R-HSA-199220;MetaCyc: PWYG-321;MetaCyc: PWY-8012;MetaCyc: PWY-8049;MetaCyc: PWY-5367;KEGG: 00780+1.1.1.100+4.2.1.59+2.3.1.41;MetaCyc: PWY-7664;MetaCyc: PWY-5142	"Palmitoleate biosynthesis II (plants and bacteria)";"Palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate)";"Fatty acyl-CoA biosynthesis";"Bryostatin biosynthesis";"Fatty acid biosynthesis";"Cis-vaccenate biosynthesis";"Bacterial bioluminescence";"Oleate biosynthesis I (plants)";"Stearate biosynthesis II (bacteria and plants)";"Mycobacterial sulfolipid biosynthesis";"(5Z)-dodecenoate biosynthesis II";"NR1H2 & NR1H3 regulate gene expression linked to lipogenesis";"Superpathway of mycolate biosynthesis";"Palmitate biosynthesis (animals and fungi, cytoplasm)";"Palmitate biosynthesis II (bacteria and plant cytoplasm)";"ChREBP activates metabolic gene expression";"Gondoate biosynthesis (anaerobic)";"8-amino-7-oxononanoate biosynthesis I";"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)";"Octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast)";"Fatty acid biosynthesis initiation (bacteria and plants)";"Fatty acid biosynthesis initiation (plant mitochondria)";"Activation of gene expression by SREBF (SREBP)";"Vitamin B5 (pantothenate) metabolism";"";"Mupirocin biosynthesis";"Pederin biosynthesis";"Petroselinate biosynthesis";"Biotin metabolism";"Oleate biosynthesis IV (anaerobic)";"Acyl-[acyl-carrier protein] thioesterase pathway"
XP_046421516.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046418946.1	9	MetaCyc: PWY-7115;MetaCyc: PWY-5743;MetaCyc: PWY-7117;MetaCyc: PWY-5744;MetaCyc: PWY-5789;MetaCyc: PWY-6142;MetaCyc: PWY-241;Reactome: R-HSA-1475029;KEGG: 00910+4.2.1.1	"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"3-hydroxypropanoate cycle";"C4 photosynthetic carbon assimilation cycle, PEPCK type";"Glyoxylate assimilation";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"C4 photosynthetic carbon assimilation cycle, NADP-ME type";"Reversible hydration of carbon dioxide";"Nitrogen metabolism"
XP_046421232.1	13	MetaCyc: PWY-7384;Reactome: R-HSA-71403;MetaCyc: PWY-5690;KEGG: 00020+6.2.1.5;KEGG: 00720+6.2.1.5;MetaCyc: PWY-5537;MetaCyc: PWY-5392;KEGG: 00660+6.2.1.5;KEGG: 00640+6.2.1.5;MetaCyc: PWY-6728;MetaCyc: PWY-5913;MetaCyc: PWY-5538;MetaCyc: PWY-6969	"Anaerobic energy metabolism (invertebrates, mitochondrial)";"Citric acid cycle (TCA cycle)";"TCA cycle II (plants and fungi)";"Citrate cycle (TCA cycle)";"Carbon fixation pathways in prokaryotes";"Pyruvate fermentation to acetate V";"Reductive TCA cycle II";"C5-Branched dibasic acid metabolism";"Propanoate metabolism";"Methylaspartate cycle";"Partial TCA cycle (obligate autotrophs)";"Pyruvate fermentation to acetate VI";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)"
XP_046432762.1	30	Reactome: R-HSA-400253;Reactome: R-HSA-68949;Reactome: R-HSA-2894862;Reactome: R-HSA-1169091;Reactome: R-HSA-2871837;Reactome: R-HSA-195253;Reactome: R-HSA-5676590;Reactome: R-HSA-9604323;Reactome: R-HSA-8939902;Reactome: R-HSA-5607761;Reactome: R-HSA-5610780;Reactome: R-HSA-69231;Reactome: R-HSA-983168;Reactome: R-HSA-2565942;Reactome: R-HSA-5684264;Reactome: R-HSA-2644607;Reactome: R-HSA-5610783;Reactome: R-HSA-5610785;Reactome: R-HSA-5607764;Reactome: R-HSA-1170546;Reactome: R-HSA-180534;Reactome: R-HSA-187577;Reactome: R-HSA-174113;Reactome: R-HSA-2122947;Reactome: R-HSA-2644606;Reactome: R-HSA-202424;Reactome: R-HSA-917937;Reactome: R-HSA-8951664;Reactome: R-HSA-8854050;Reactome: R-HSA-9020702	"Circadian Clock";"Orc1 removal from chromatin";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Activation of NF-kappaB in B cells";"FCERI mediated NF-kB activation";"Degradation of beta-catenin by the destruction complex";"NIK-->noncanonical NF-kB signaling";"Negative regulation of NOTCH4 signaling";"Regulation of RUNX2 expression and activity";"Dectin-1 mediated noncanonical NF-kB signaling";"Degradation of GLI1 by the proteasome";"Cyclin D associated events in G1";"Antigen processing: Ubiquitination & Proteasome degradation";"Regulation of PLK1 Activity at G2/M Transition";"MAP3K8 (TPL2)-dependent MAPK1/3 activation";"Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling";"Degradation of GLI2 by the proteasome";"GLI3 is processed to GLI3R by the proteasome";"CLEC7A (Dectin-1) signaling";"Prolactin receptor signaling";"Vpu mediated degradation of CD4";"SCF(Skp2)-mediated degradation of p27/p21";"SCF-beta-TrCP mediated degradation of Emi1";"NOTCH1 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Downstream TCR signaling";"Iron uptake and transport";"Neddylation";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Interleukin-1 signaling"
XP_046412654.1	4	Reactome: R-HSA-350054;Reactome: R-HSA-2644606;Reactome: R-HSA-2122947;Reactome: R-HSA-2894862	"Notch-HLH transcription pathway";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH1 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants"
XP_046413854.1	2	Reactome: R-HSA-3238698;Reactome: R-HSA-373080	"WNT ligand biogenesis and trafficking";"Class B/2 (Secretin family receptors)"
XP_046421961.1	2	Reactome: R-HSA-1296052;Reactome: R-HSA-418457	"Ca2+ activated K+ channels";"cGMP effects"
XP_046421834.1	1	Reactome: R-HSA-191859	"snRNP Assembly"
XP_046431747.1	4	KEGG: 00640+1.2.1.27;KEGG: 00280+1.2.1.27;Reactome: R-HSA-70895;MetaCyc: PWY-5642	"Propanoate metabolism";"Valine, leucine and isoleucine degradation";"Branched-chain amino acid catabolism";"2,4-dinitrotoluene degradation"
XP_046421243.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046427488.1	2	Reactome: R-HSA-5576892;Reactome: R-HSA-5576893	"Phase 0 - rapid depolarisation";"Phase 2 - plateau phase"
XP_046425374.1	2	Reactome: R-HSA-917729;Reactome: R-HSA-162588	"Endosomal Sorting Complex Required For Transport (ESCRT)";"Budding and maturation of HIV virion"
XP_046415107.1	11	KEGG: 00230+1.17.1.4;MetaCyc: PWY-5497;MetaCyc: PWY-6596;MetaCyc: PWY-6999;MetaCyc: PWY-6606;MetaCyc: PWY-6608;MetaCyc: PWY-5695;Reactome: R-HSA-74259;MetaCyc: PWY-6538;MetaCyc: PWY-6607;Reactome: R-HSA-8851680	"Purine metabolism";"Purine nucleobases degradation II (anaerobic)";"Adenosine nucleotides degradation I";"Theophylline degradation";"Guanosine nucleotides degradation II";"Guanosine nucleotides degradation III";"Inosine 5'-phosphate degradation";"Purine catabolism";"Caffeine degradation III (bacteria, via demethylation)";"Guanosine nucleotides degradation I";"Butyrophilin (BTN) family interactions"
XP_046426666.1	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
XP_046427259.1	8	KEGG: 00983+3.5.4.5;KEGG: 00240+3.5.4.5;MetaCyc: PWY-7181;Reactome: R-HSA-6798695;MetaCyc: PWY-7193;MetaCyc: PWY-6556;MetaCyc: PWY-7199;Reactome: R-HSA-73614	"Drug metabolism - other enzymes";"Pyrimidine metabolism";"Pyrimidine deoxyribonucleosides degradation";"Neutrophil degranulation";"Pyrimidine ribonucleosides salvage I";"Pyrimidine ribonucleosides salvage II";"Pyrimidine deoxyribonucleosides salvage";"Pyrimidine salvage"
XP_046422166.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046409747.1	3	KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation"
XP_046430135.1	56	Reactome: R-HSA-8948751;Reactome: R-HSA-1234176;Reactome: R-HSA-69481;Reactome: R-HSA-8852276;Reactome: R-HSA-5610783;Reactome: R-HSA-5689603;Reactome: R-HSA-68827;Reactome: R-HSA-5607764;Reactome: R-HSA-187577;Reactome: R-HSA-180534;Reactome: R-HSA-174113;Reactome: R-HSA-5687128;Reactome: R-HSA-8854050;Reactome: R-HSA-9020702;Reactome: R-HSA-1169091;Reactome: R-HSA-382556;Reactome: R-HSA-68949;Reactome: R-HSA-2871837;Reactome: R-HSA-174178;Reactome: R-HSA-195253;Reactome: R-HSA-69601;Reactome: R-HSA-69017;Reactome: R-HSA-5358346;Reactome: R-HSA-5362768;Reactome: R-HSA-9604323;Reactome: R-HSA-5676590;Reactome: R-HSA-5668541;Reactome: R-HSA-9010553;Reactome: R-HSA-350562;Reactome: R-HSA-8941858;Reactome: R-HSA-1236974;Reactome: R-HSA-450408;Reactome: R-HSA-5610780;Reactome: R-HSA-5632684;Reactome: R-HSA-211733;Reactome: R-HSA-4641258;Reactome: R-HSA-8939236;Reactome: R-HSA-5678895;Reactome: R-HSA-180585;Reactome: R-HSA-5610785;Reactome: R-HSA-1236978;Reactome: R-HSA-4641257;Reactome: R-HSA-4608870;Reactome: R-HSA-202424;Reactome: R-HSA-75815;Reactome: R-HSA-8951664;Reactome: R-HSA-174084;Reactome: R-HSA-5689880;Reactome: R-HSA-349425;Reactome: R-HSA-2467813;Reactome: R-HSA-174154;Reactome: R-HSA-174184;Reactome: R-HSA-8939902;Reactome: R-HSA-5607761;Reactome: R-HSA-983168;Reactome: R-HSA-5658442	"Regulation of PTEN stability and activity";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"G2/M Checkpoints";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Degradation of GLI2 by the proteasome";"UCH proteinases";"CDT1 association with the CDC6:ORC:origin complex";"CLEC7A (Dectin-1) signaling";"SCF(Skp2)-mediated degradation of p27/p21";"Vpu mediated degradation of CD4";"SCF-beta-TrCP mediated degradation of Emi1";"MAPK6/MAPK4 signaling";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Interleukin-1 signaling";"Activation of NF-kappaB in B cells";"ABC-family proteins mediated transport";"Orc1 removal from chromatin";"FCERI mediated NF-kB activation";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Degradation of beta-catenin by the destruction complex";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"CDK-mediated phosphorylation and removal of Cdc6";"Hedgehog ligand biogenesis";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Negative regulation of NOTCH4 signaling";"NIK-->noncanonical NF-kB signaling";"TNFR2 non-canonical NF-kB pathway";"Regulation of expression of SLITs and ROBOs";"Regulation of ornithine decarboxylase (ODC)";"Regulation of RUNX3 expression and activity";"ER-Phagosome pathway";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Degradation of GLI1 by the proteasome";"Hedgehog 'on' state";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Degradation of DVL";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Defective CFTR causes cystic fibrosis";"Vif-mediated degradation of APOBEC3G";"GLI3 is processed to GLI3R by the proteasome";"Cross-presentation of soluble exogenous antigens (endosomes)";"Degradation of AXIN";"Asymmetric localization of PCP proteins";"Downstream TCR signaling";"Ubiquitin-dependent degradation of Cyclin D";"Neddylation";"Autodegradation of Cdh1 by Cdh1:APC/C";"Ub-specific processing proteases";"Autodegradation of the E3 ubiquitin ligase COP1";"Separation of Sister Chromatids";"APC/C:Cdc20 mediated degradation of Securin";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Regulation of RUNX2 expression and activity";"Dectin-1 mediated noncanonical NF-kB signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Regulation of RAS by GAPs"
XP_046428377.1	2	MetaCyc: PWY-7221;KEGG: 00230+2.7.4.8	"Guanosine ribonucleotides de novo biosynthesis";"Purine metabolism"
XP_046410891.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_046429193.1	2	Reactome: R-HSA-2408522;Reactome: R-HSA-379716	"Selenoamino acid metabolism";"Cytosolic tRNA aminoacylation"
XP_046413522.1	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
XP_046434947.1	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
XP_046420058.1	1	Reactome: R-HSA-9639288	"Amino acids regulate mTORC1"
XP_046428621.1	2	Reactome: R-HSA-379726;KEGG: 00970+6.1.1.4	"Mitochondrial tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis"
XP_046430108.1	1	Reactome: R-HSA-6790901	"rRNA modification in the nucleus and cytosol"
XP_046429874.1	7	Reactome: R-HSA-69656;Reactome: R-HSA-69202;Reactome: R-HSA-1538133;Reactome: R-HSA-69205;Reactome: R-HSA-1362277;Reactome: R-HSA-156711;Reactome: R-HSA-1362300	"Cyclin A:Cdk2-associated events at S phase entry";"Cyclin E associated events during G1/S transition";"G0 and Early G1";"G1/S-Specific Transcription";"Transcription of E2F targets under negative control by DREAM complex";"Polo-like kinase mediated events";"Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1"
XP_046420644.1	11	Reactome: R-HSA-6804756;Reactome: R-HSA-69473;Reactome: R-HSA-5685938;Reactome: R-HSA-5358565;Reactome: R-HSA-5693616;Reactome: R-HSA-5693554;Reactome: R-HSA-5358606;Reactome: R-HSA-5693568;Reactome: R-HSA-5693579;Reactome: R-HSA-5685942;Reactome: R-HSA-5693607	"Regulation of TP53 Activity through Phosphorylation";"G2/M DNA damage checkpoint";"HDR through Single Strand Annealing (SSA)";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"Presynaptic phase of homologous DNA pairing and strand exchange";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"Resolution of D-loop Structures through Holliday Junction Intermediates";"Homologous DNA Pairing and Strand Exchange";"HDR through Homologous Recombination (HRR)";"Processing of DNA double-strand break ends"
XP_046411252.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_046426006.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-8866654	"Protein ubiquitination";"E3 ubiquitin ligases ubiquitinate target proteins"
XP_046431230.1	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840	"Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation"
XP_046435689.1	2	Reactome: R-HSA-3299685;KEGG: 00480+1.11.1.15	"Detoxification of Reactive Oxygen Species";"Glutathione metabolism"
XP_046421225.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_046420872.1	7	Reactome: R-HSA-5578999;MetaCyc: PWY-8043;MetaCyc: PWY-6840;MetaCyc: PWY-7255;Reactome: R-HSA-174403;KEGG: 00480+6.3.2.2;KEGG: 00270+6.3.2.2	"Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD)";"Ophthalmate biosynthesis";"Homoglutathione biosynthesis";"Ergothioneine biosynthesis I (bacteria)";"Glutathione synthesis and recycling";"Glutathione metabolism";"Cysteine and methionine metabolism"
XP_046426239.1	1	Reactome: R-HSA-1474228	"Degradation of the extracellular matrix"
XP_046425090.1	2	Reactome: R-HSA-3238698;Reactome: R-HSA-373080	"WNT ligand biogenesis and trafficking";"Class B/2 (Secretin family receptors)"
XP_046419777.1	1	Reactome: R-HSA-390522	"Striated Muscle Contraction"
XP_046410171.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_046421292.1	5	Reactome: R-HSA-189451;MetaCyc: PWY-5189;KEGG: 00260+2.3.1.37;MetaCyc: PWY-7536;KEGG: 00860+2.3.1.37	"Heme biosynthesis";"Tetrapyrrole biosynthesis II (from glycine)";"Glycine, serine and threonine metabolism";"2-amino-3-hydroxycyclopent-2-enone biosynthesis";"Porphyrin and chlorophyll metabolism"
XP_046409488.1	2	Reactome: R-HSA-975577;Reactome: R-HSA-2022854	"N-Glycan antennae elongation";"Keratan sulfate biosynthesis"
XP_046418084.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046417074.1	4	KEGG: 00510+2.4.1.258;Reactome: R-HSA-446193;Reactome: R-HSA-4720475;KEGG: 00513+2.4.1.258	"N-Glycan biosynthesis";"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"Defective ALG3 causes ALG3-CDG (CDG-1d)";"Various types of N-glycan biosynthesis"
XP_046417383.1	2	Reactome: R-HSA-6811436;Reactome: R-HSA-8876198	"COPI-independent Golgi-to-ER retrograde traffic";"RAB GEFs exchange GTP for GDP on RABs"
XP_046432716.1	6	KEGG: 00510+2.4.1.143;MetaCyc: PWY-7426;Reactome: R-HSA-4793952;KEGG: 00513+2.4.1.143;MetaCyc: PWY-7920;Reactome: R-HSA-975578	"N-Glycan biosynthesis";"Complex N-linked glycan biosynthesis (vertebrates)";"Defective MGAT2 causes MGAT2-CDG (CDG-2a)";"Various types of N-glycan biosynthesis";"Complex N-linked glycan biosynthesis (plants)";"Reactions specific to the complex N-glycan synthesis pathway"
XP_046436307.1	4	Reactome: R-HSA-6798163;KEGG: 00260+1.2.1.8+1.1.99.1;MetaCyc: PWY-3722;MetaCyc: PWY-7494	"Choline catabolism";"Glycine, serine and threonine metabolism";"Glycine betaine biosynthesis II (Gram-positive bacteria)";"Choline degradation IV"
XP_046431486.1	2	Reactome: R-HSA-373080;Reactome: R-HSA-3238698	"Class B/2 (Secretin family receptors)";"WNT ligand biogenesis and trafficking"
XP_046421247.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046422706.1	1	Reactome: R-HSA-425561	"Sodium/Calcium exchangers"
XP_046409775.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_046428780.1	3	KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway"
XP_046417170.1	2	Reactome: R-HSA-390471;Reactome: R-HSA-1660662	"Association of TriC/CCT with target proteins during biosynthesis";"Glycosphingolipid metabolism"
XP_046422647.1	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
XP_046433160.1	14	Reactome: R-HSA-5696400;Reactome: R-HSA-5656169;Reactome: R-HSA-110320;Reactome: R-HSA-6782135;Reactome: R-HSA-5651801;Reactome: R-HSA-110312;Reactome: R-HSA-174411;Reactome: R-HSA-5656121;Reactome: R-HSA-110314;Reactome: R-HSA-5696397;Reactome: R-HSA-69091;Reactome: R-HSA-5685942;Reactome: R-HSA-6782210;Reactome: R-HSA-5655862	"Dual Incision in GG-NER";"Termination of translesion DNA synthesis";"Translesion Synthesis by POLH";"Dual incision in TC-NER";"PCNA-Dependent Long Patch Base Excision Repair";"Translesion synthesis by REV1";"Polymerase switching on the C-strand of the telomere";"Translesion synthesis by POLI";"Recognition of DNA damage by PCNA-containing replication complex";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Polymerase switching";"HDR through Homologous Recombination (HRR)";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Translesion synthesis by POLK"
XP_046418774.1	3	KEGG: 00230+4.6.1.2;Reactome: R-HSA-445355;Reactome: R-HSA-392154	"Purine metabolism";"Smooth Muscle Contraction";"Nitric oxide stimulates guanylate cyclase"
XP_046413584.1	6	KEGG: 00630+1.11.1.6;Reactome: R-HSA-6798695;KEGG: 00380+1.11.1.6;Reactome: R-HSA-9615017;Reactome: R-HSA-9033241;Reactome: R-HSA-3299685	"Glyoxylate and dicarboxylate metabolism";"Neutrophil degranulation";"Tryptophan metabolism";"FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes";"Peroxisomal protein import";"Detoxification of Reactive Oxygen Species"
XP_046428848.1	5	MetaCyc: PWY-7863;KEGG: 00740+2.7.1.26;MetaCyc: PWY-6168;Reactome: R-HSA-196843;MetaCyc: PWY-5523	"Roseoflavin biosynthesis";"Riboflavin metabolism";"Flavin biosynthesis III (fungi)";"Vitamin B2 (riboflavin) metabolism";"5,6-dimethylbenzimidazole biosynthesis I (aerobic)"
XP_046427916.1	6	MetaCyc: PWY-7817;KEGG: 00561+2.7.1.107;MetaCyc: PWY-7039;KEGG: 04070+2.7.1.107;KEGG: 00564+2.7.1.107;Reactome: R-HSA-114508	"Type I lipoteichoic acid biosynthesis (S. aureus)";"Glycerolipid metabolism";"Phosphatidate metabolism, as a signaling molecule";"Phosphatidylinositol signaling system";"Glycerophospholipid metabolism";"Effects of PIP2 hydrolysis"
XP_046436270.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046422793.1	1	Reactome: R-HSA-432722	"Golgi Associated Vesicle Biogenesis"
XP_046424509.1	1	Reactome: R-HSA-1445148	"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
XP_046436004.1	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
XP_046414640.1	14	MetaCyc: PWY-7782;MetaCyc: PWY-7589;MetaCyc: PWY-8053;MetaCyc: PWY-5981;MetaCyc: PWY-7417;MetaCyc: PWY-6453;KEGG: 00564+2.3.1.51;MetaCyc: PWY-8051;KEGG: 00561+2.3.1.51;MetaCyc: PWY-8055;MetaCyc: PWY-5667;Reactome: R-HSA-1483166;MetaCyc: PWY-7411;MetaCyc: PWY-7587	"Plasmalogen biosynthesis";"Palmitoleate biosynthesis III (cyanobacteria)";"Anandamide biosynthesis II";"CDP-diacylglycerol biosynthesis III";"Phospholipid remodeling (phosphatidate, yeast)";"Stigma estolide biosynthesis";"Glycerophospholipid metabolism";"Anandamide biosynthesis I";"Glycerolipid metabolism";"Palmitoyl ethanolamide biosynthesis";"CDP-diacylglycerol biosynthesis I";"Synthesis of PA";"Phosphatidate biosynthesis (yeast)";"Oleate biosynthesis III (cyanobacteria)"
XP_046416900.1	7	MetaCyc: PWY-5265;Reactome: R-HSA-4549356;Reactome: R-HSA-446193;KEGG: 00510+2.7.8.15;KEGG: 00550+2.7.8.13;MetaCyc: PWY-6471;MetaCyc: PWY-6470	"Peptidoglycan biosynthesis II (staphylococci)";"Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2";"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"N-Glycan biosynthesis";"Peptidoglycan biosynthesis";"Peptidoglycan biosynthesis IV (Enterococcus faecium)";"Peptidoglycan biosynthesis V (beta-lactam resistance)"
XP_046431328.1	2	KEGG: 00901+2.7.1.222;MetaCyc: PWY-7936	"Indole alkaloid biosynthesis";"Psilocybin biosynthesis"
XP_046423743.1	12	Reactome: R-HSA-76061;Reactome: R-HSA-749476;Reactome: R-HSA-1834949;Reactome: R-HSA-73762;Reactome: R-HSA-73772;Reactome: R-HSA-5250924;Reactome: R-HSA-76066;Reactome: R-HSA-427413;Reactome: R-HSA-76071;Reactome: R-HSA-73980;Reactome: R-HSA-73863;Reactome: R-HSA-73780	"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Abortive And Retractive Initiation";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase I Transcription Initiation";"RNA Polymerase I Promoter Escape";"B-WICH complex positively regulates rRNA expression";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"NoRC negatively regulates rRNA expression";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"RNA Polymerase III Transcription Termination";"RNA Polymerase I Transcription Termination";"RNA Polymerase III Chain Elongation"
XP_046425440.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046433557.1	3	Reactome: R-HSA-1358803;Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Downregulation of ERBB2:ERBB3 signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_046435444.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046421063.1	4	Reactome: R-HSA-983189;Reactome: R-HSA-2132295;Reactome: R-HSA-5625970;Reactome: R-HSA-6811434	"Kinesins";"MHC class II antigen presentation";"RHO GTPases activate KTN1";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_046413840.1	16	Reactome: R-HSA-176412;Reactome: R-HSA-179409;Reactome: R-HSA-174048;Reactome: R-HSA-176409;Reactome: R-HSA-8853884;Reactome: R-HSA-174084;Reactome: R-HSA-2467813;Reactome: R-HSA-2559582;Reactome: R-HSA-174178;Reactome: R-HSA-174154;Reactome: R-HSA-69017;Reactome: R-HSA-176407;Reactome: R-HSA-174184;Reactome: R-HSA-176408;Reactome: R-HSA-141430;Reactome: R-HSA-983168	"Phosphorylation of the APC/C";"APC-Cdc20 mediated degradation of Nek2A";"APC/C:Cdc20 mediated degradation of Cyclin B";"APC/C:Cdc20 mediated degradation of mitotic proteins";"Transcriptional Regulation by VENTX";"Autodegradation of Cdh1 by Cdh1:APC/C";"Separation of Sister Chromatids";"Senescence-Associated Secretory Phenotype (SASP)";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"APC/C:Cdc20 mediated degradation of Securin";"CDK-mediated phosphorylation and removal of Cdc6";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Regulation of APC/C activators between G1/S and early anaphase";"Inactivation of APC/C via direct inhibition of the APC/C complex";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046422206.1	2	Reactome: R-HSA-3214858;Reactome: R-HSA-8939243	"RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"
XP_046426223.1	1	Reactome: R-HSA-6803157	"Antimicrobial peptides"
XP_046422859.1	1	Reactome: R-HSA-426048	"Arachidonate production from DAG"
XP_046422321.1	6	Reactome: R-HSA-73856;Reactome: R-HSA-975957;Reactome: R-HSA-159236;Reactome: R-HSA-72187;Reactome: R-HSA-9010553;Reactome: R-HSA-72163	"RNA Polymerase II Transcription Termination";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"mRNA 3'-end processing";"Regulation of expression of SLITs and ROBOs";"mRNA Splicing - Major Pathway"
XP_046433146.1	1	Reactome: R-HSA-1632852	"Macroautophagy"
XP_046410279.1	2	Reactome: R-HSA-6804115;Reactome: R-HSA-429947	"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Deadenylation of mRNA"
XP_046434127.1	1	Reactome: R-HSA-5662702	"Melanin biosynthesis"
XP_046426413.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046426455.1	1	Reactome: R-HSA-5626467	"RHO GTPases activate IQGAPs"
XP_046432868.1	1	Reactome: R-HSA-6809371	"Formation of the cornified envelope"
XP_046431700.1	5	Reactome: R-HSA-376172;Reactome: R-HSA-171007;KEGG: 04150+2.7.11.24;Reactome: R-HSA-4420097;Reactome: R-HSA-168638	"DSCAM interactions";"p38MAPK events";"mTOR signaling pathway";"VEGFA-VEGFR2 Pathway";"NOD1/2 Signaling Pathway"
XP_046419497.1	3	Reactome: R-HSA-3000157;Reactome: R-HSA-8874081;Reactome: R-HSA-3000171	"Laminin interactions";"MET activates PTK2 signaling";"Non-integrin membrane-ECM interactions"
XP_046420330.1	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
XP_046414730.1	1	Reactome: R-HSA-432720	"Lysosome Vesicle Biogenesis"
XP_046422666.1	2	Reactome: R-HSA-399719;Reactome: R-HSA-190873	"Trafficking of AMPA receptors";"Gap junction degradation"
XP_046415781.1	2	Reactome: R-HSA-8866907;Reactome: R-HSA-8866904	"Activation of the TFAP2 (AP-2) family of transcription factors";"Negative regulation of activity of TFAP2 (AP-2) family transcription factors"
XP_046415095.1	1	MetaCyc: PWY-6308	"L-cysteine biosynthesis II (tRNA-dependent)"
XP_046419271.1	23	Reactome: R-HSA-6814122;Reactome: R-HSA-8964616;Reactome: R-HSA-392170;Reactome: R-HSA-9009391;Reactome: R-HSA-4086398;Reactome: R-HSA-418217;Reactome: R-HSA-456926;Reactome: R-HSA-392451;Reactome: R-HSA-418594;Reactome: R-HSA-202040;Reactome: R-HSA-416476;Reactome: R-HSA-418597;Reactome: R-HSA-500657;Reactome: R-HSA-400042;Reactome: R-HSA-418555;Reactome: R-HSA-392851;Reactome: R-HSA-416482;Reactome: R-HSA-418592;Reactome: R-HSA-381676;Reactome: R-HSA-420092;Reactome: R-HSA-428930;Reactome: R-HSA-8964315;Reactome: R-HSA-432040	"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"G beta:gamma signalling through CDC42";"ADP signalling through P2Y purinoceptor 12";"Extra-nuclear estrogen signaling";"Ca2+ pathway";"G beta:gamma signalling through PLC beta";"Thrombin signalling through proteinase activated receptors (PARs)";"G beta:gamma signalling through PI3Kgamma";"G alpha (i) signalling events";"G-protein activation";"G alpha (q) signalling events";"G alpha (z) signalling events";"Presynaptic function of Kainate receptors";"Adrenaline,noradrenaline inhibits insulin secretion";"G alpha (s) signalling events";"Prostacyclin signalling through prostacyclin receptor";"G alpha (12/13) signalling events";"ADP signalling through P2Y purinoceptor 1";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"Glucagon-type ligand receptors";"Thromboxane signalling through TP receptor";"G beta:gamma signalling through BTK";"Vasopressin regulates renal water homeostasis via Aquaporins"
XP_046415964.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046419818.1	5	KEGG: 00250+2.6.1.16;MetaCyc: PWY-8013;MetaCyc: PWY-6749;KEGG: 00520+2.6.1.16;Reactome: R-HSA-446210	"Alanine, aspartate and glutamate metabolism";"UDP-N-acetyl-D-galactosamine biosynthesis III";"CMP-legionaminate biosynthesis I";"Amino sugar and nucleotide sugar metabolism";"Synthesis of UDP-N-acetyl-glucosamine"
XP_046427510.1	3	KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation"
XP_046431914.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_046427704.1	12	MetaCyc: PWY-6277;Reactome: R-HSA-73817;MetaCyc: PWY-6121;KEGG: 00670+2.1.2.2;Reactome: R-HSA-196780;KEGG: 00230+2.1.2.2;KEGG: 00970+2.1.2.9;MetaCyc: PWY-6122;KEGG: 00230+6.3.3.1;MetaCyc: PWY-6613;KEGG: 00670+2.1.2.9;KEGG: 00230+6.3.4.13	"Superpathway of 5-aminoimidazole ribonucleotide biosynthesis";"Purine ribonucleoside monophosphate biosynthesis";"5-aminoimidazole ribonucleotide biosynthesis I";"One carbon pool by folate";"Biotin transport and metabolism";"Purine metabolism";"Aminoacyl-tRNA biosynthesis";"5-aminoimidazole ribonucleotide biosynthesis II";"Purine metabolism";"Tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate";"One carbon pool by folate";"Purine metabolism"
XP_046419544.1	2	Reactome: R-HSA-163841;KEGG: 00900+2.1.1.100	"Gamma carboxylation, hypusine formation and arylsulfatase activation";"Terpenoid backbone biosynthesis"
XP_046421374.1	3	MetaCyc: PWY-5669;KEGG: 00564+4.1.1.65;Reactome: R-HSA-1483213	"Phosphatidylserine and phosphatidylethanolamine biosynthesis I";"Glycerophospholipid metabolism";"Synthesis of PE"
XP_046431398.1	9	KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;Reactome: R-HSA-198323;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;Reactome: R-HSA-5674400;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04714+2.7.11.1	"PI3K-Akt signaling pathway";"mTOR signaling pathway";"AKT phosphorylates targets in the cytosol";"Relaxin signaling pathway";"Human cytomegalovirus infection";"Constitutive Signaling by AKT1 E17K in Cancer";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Thermogenesis"
XP_046423690.1	1	KEGG: 00970+6.1.1.7	"Aminoacyl-tRNA biosynthesis"
XP_046413617.1	1	Reactome: R-HSA-6809371	"Formation of the cornified envelope"
XP_046419157.1	9	Reactome: R-HSA-6798695;Reactome: R-HSA-445355;Reactome: R-HSA-6802946;Reactome: R-HSA-5674135;Reactome: R-HSA-6802948;Reactome: R-HSA-6802952;Reactome: R-HSA-9649948;Reactome: R-HSA-6802955;Reactome: R-HSA-114608	"Neutrophil degranulation";"Smooth Muscle Contraction";"Signaling by moderate kinase activity BRAF mutants";"MAP2K and MAPK activation";"Signaling by high-kinase activity BRAF mutants";"Signaling by BRAF and RAF fusions";"Signaling downstream of RAS mutants";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"Platelet degranulation"
XP_046426555.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_046410068.1	3	Reactome: R-HSA-9603798;Reactome: R-HSA-8866654;Reactome: R-HSA-9033241	"Class I peroxisomal membrane protein import";"E3 ubiquitin ligases ubiquitinate target proteins";"Peroxisomal protein import"
XP_046428373.1	2	MetaCyc: PWY-7221;KEGG: 00230+2.7.4.8	"Guanosine ribonucleotides de novo biosynthesis";"Purine metabolism"
XP_046433151.1	14	Reactome: R-HSA-6782135;Reactome: R-HSA-110320;Reactome: R-HSA-5696400;Reactome: R-HSA-5656169;Reactome: R-HSA-110312;Reactome: R-HSA-174411;Reactome: R-HSA-5651801;Reactome: R-HSA-69091;Reactome: R-HSA-5685942;Reactome: R-HSA-5696397;Reactome: R-HSA-110314;Reactome: R-HSA-5656121;Reactome: R-HSA-5655862;Reactome: R-HSA-6782210	"Dual incision in TC-NER";"Translesion Synthesis by POLH";"Dual Incision in GG-NER";"Termination of translesion DNA synthesis";"Translesion synthesis by REV1";"Polymerase switching on the C-strand of the telomere";"PCNA-Dependent Long Patch Base Excision Repair";"Polymerase switching";"HDR through Homologous Recombination (HRR)";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Recognition of DNA damage by PCNA-containing replication complex";"Translesion synthesis by POLI";"Translesion synthesis by POLK";"Gap-filling DNA repair synthesis and ligation in TC-NER"
XP_046410130.1	6	Reactome: R-HSA-1855183;Reactome: R-HSA-1660516;KEGG: 04070+3.1.3.66;Reactome: R-HSA-1660499;MetaCyc: PWY-6368;KEGG: 00562+3.1.3.66	"Synthesis of IP2, IP, and Ins in the cytosol";"Synthesis of PIPs at the early endosome membrane";"Phosphatidylinositol signaling system";"Synthesis of PIPs at the plasma membrane";"3-phosphoinositide degradation";"Inositol phosphate metabolism"
XP_046434847.1	56	Reactome: R-HSA-5676590;Reactome: R-HSA-5362768;Reactome: R-HSA-9604323;Reactome: R-HSA-5358346;Reactome: R-HSA-69601;Reactome: R-HSA-69017;Reactome: R-HSA-1169091;Reactome: R-HSA-382556;Reactome: R-HSA-68949;Reactome: R-HSA-195253;Reactome: R-HSA-2871837;Reactome: R-HSA-174178;Reactome: R-HSA-5610780;Reactome: R-HSA-450408;Reactome: R-HSA-1236974;Reactome: R-HSA-4641258;Reactome: R-HSA-211733;Reactome: R-HSA-5632684;Reactome: R-HSA-8941858;Reactome: R-HSA-9010553;Reactome: R-HSA-350562;Reactome: R-HSA-5668541;Reactome: R-HSA-68827;Reactome: R-HSA-5689603;Reactome: R-HSA-187577;Reactome: R-HSA-180534;Reactome: R-HSA-5607764;Reactome: R-HSA-69481;Reactome: R-HSA-1234176;Reactome: R-HSA-8948751;Reactome: R-HSA-5610783;Reactome: R-HSA-8852276;Reactome: R-HSA-9020702;Reactome: R-HSA-8854050;Reactome: R-HSA-174113;Reactome: R-HSA-5687128;Reactome: R-HSA-174154;Reactome: R-HSA-8939902;Reactome: R-HSA-174184;Reactome: R-HSA-2467813;Reactome: R-HSA-5607761;Reactome: R-HSA-5658442;Reactome: R-HSA-983168;Reactome: R-HSA-5678895;Reactome: R-HSA-180585;Reactome: R-HSA-5610785;Reactome: R-HSA-8939236;Reactome: R-HSA-8951664;Reactome: R-HSA-5689880;Reactome: R-HSA-174084;Reactome: R-HSA-349425;Reactome: R-HSA-1236978;Reactome: R-HSA-202424;Reactome: R-HSA-75815;Reactome: R-HSA-4641257;Reactome: R-HSA-4608870	"NIK-->noncanonical NF-kB signaling";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Negative regulation of NOTCH4 signaling";"Hedgehog ligand biogenesis";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"CDK-mediated phosphorylation and removal of Cdc6";"Activation of NF-kappaB in B cells";"ABC-family proteins mediated transport";"Orc1 removal from chromatin";"Degradation of beta-catenin by the destruction complex";"FCERI mediated NF-kB activation";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Degradation of GLI1 by the proteasome";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"ER-Phagosome pathway";"Degradation of DVL";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Hedgehog 'on' state";"Regulation of RUNX3 expression and activity";"Regulation of expression of SLITs and ROBOs";"Regulation of ornithine decarboxylase (ODC)";"TNFR2 non-canonical NF-kB pathway";"CDT1 association with the CDC6:ORC:origin complex";"UCH proteinases";"SCF(Skp2)-mediated degradation of p27/p21";"Vpu mediated degradation of CD4";"CLEC7A (Dectin-1) signaling";"G2/M Checkpoints";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of PTEN stability and activity";"Degradation of GLI2 by the proteasome";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Interleukin-1 signaling";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"SCF-beta-TrCP mediated degradation of Emi1";"MAPK6/MAPK4 signaling";"APC/C:Cdc20 mediated degradation of Securin";"Regulation of RUNX2 expression and activity";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Separation of Sister Chromatids";"Dectin-1 mediated noncanonical NF-kB signaling";"Regulation of RAS by GAPs";"Antigen processing: Ubiquitination & Proteasome degradation";"Defective CFTR causes cystic fibrosis";"Vif-mediated degradation of APOBEC3G";"GLI3 is processed to GLI3R by the proteasome";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Neddylation";"Ub-specific processing proteases";"Autodegradation of Cdh1 by Cdh1:APC/C";"Autodegradation of the E3 ubiquitin ligase COP1";"Cross-presentation of soluble exogenous antigens (endosomes)";"Downstream TCR signaling";"Ubiquitin-dependent degradation of Cyclin D";"Degradation of AXIN";"Asymmetric localization of PCP proteins"
XP_046420937.1	1	Reactome: R-HSA-1660662	"Glycosphingolipid metabolism"
XP_046424960.1	4	Reactome: R-HSA-6781823;Reactome: R-HSA-8951664;Reactome: R-HSA-5696394;Reactome: R-HSA-8856825	"Formation of TC-NER Pre-Incision Complex";"Neddylation";"DNA Damage Recognition in GG-NER";"Cargo recognition for clathrin-mediated endocytosis"
XP_046430961.1	4	KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16;Reactome: R-HSA-180024;KEGG: 04660+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation";"DARPP-32 events";"T cell receptor signaling pathway"
XP_046416942.1	3	KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation"
XP_046413957.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046410457.1	7	KEGG: 00030+3.1.1.31;MetaCyc: PWY-8004;MetaCyc: PWY-6906;MetaCyc: PWY-5514;Reactome: R-HSA-71336;MetaCyc: PWY-6855;KEGG: 00520+3.5.99.6	"Pentose phosphate pathway";"Entner-Doudoroff pathway I";"Chitin derivatives degradation";"UDP-N-acetyl-D-galactosamine biosynthesis II";"Pentose phosphate pathway";"Chitin degradation I (archaea)";"Amino sugar and nucleotide sugar metabolism"
XP_046412235.1	1	Reactome: R-HSA-8866654	"E3 ubiquitin ligases ubiquitinate target proteins"
XP_046413065.1	5	Reactome: R-HSA-9649948;Reactome: R-HSA-6802955;Reactome: R-HSA-5675221;Reactome: R-HSA-5673000;Reactome: R-HSA-6802946	"Signaling downstream of RAS mutants";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"Negative regulation of MAPK pathway";"RAF activation";"Signaling by moderate kinase activity BRAF mutants"
XP_046419589.1	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
XP_046429227.1	2	Reactome: R-HSA-6807878;Reactome: R-HSA-6811434	"COPI-mediated anterograde transport";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_046419158.1	9	Reactome: R-HSA-445355;Reactome: R-HSA-6798695;Reactome: R-HSA-6802946;Reactome: R-HSA-6802952;Reactome: R-HSA-9649948;Reactome: R-HSA-6802948;Reactome: R-HSA-5674135;Reactome: R-HSA-114608;Reactome: R-HSA-6802955	"Smooth Muscle Contraction";"Neutrophil degranulation";"Signaling by moderate kinase activity BRAF mutants";"Signaling by BRAF and RAF fusions";"Signaling downstream of RAS mutants";"Signaling by high-kinase activity BRAF mutants";"MAP2K and MAPK activation";"Platelet degranulation";"Paradoxical activation of RAF signaling by kinase inactive BRAF"
XP_046418741.1	7	MetaCyc: PWY-6610;MetaCyc: PWY-7805;Reactome: R-HSA-74217;MetaCyc: PWY-6605;Reactome: R-HSA-6798695;MetaCyc: PWY-7807;KEGG: 00230+2.4.2.7	"Adenine salvage";"(aminomethyl)phosphonate degradation";"Purine salvage";"Adenine and adenosine salvage II";"Neutrophil degranulation";"Glyphosate degradation III";"Purine metabolism"
XP_046427120.1	1	Reactome: R-HSA-111465	"Apoptotic cleavage of cellular proteins"
XP_046431131.1	2	Reactome: R-HSA-445355;Reactome: R-HSA-390522	"Smooth Muscle Contraction";"Striated Muscle Contraction"
XP_046421652.1	2	Reactome: R-HSA-373752;Reactome: R-HSA-525793	"Netrin-1 signaling";"Myogenesis"
XP_046414436.1	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_046432909.1	1	Reactome: R-HSA-110362	"POLB-Dependent Long Patch Base Excision Repair"
XP_046433229.1	3	KEGG: 05235+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 04660+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Th1 and Th2 cell differentiation";"T cell receptor signaling pathway"
XP_046427056.1	8	Reactome: R-HSA-380259;Reactome: R-HSA-380320;Reactome: R-HSA-2565942;Reactome: R-HSA-380284;Reactome: R-HSA-8854518;Reactome: R-HSA-380270;Reactome: R-HSA-5620912;Reactome: R-HSA-5689880	"Loss of Nlp from mitotic centrosomes";"Recruitment of NuMA to mitotic centrosomes";"Regulation of PLK1 Activity at G2/M Transition";"Loss of proteins required for interphase microtubule organization from the centrosome";"AURKA Activation by TPX2";"Recruitment of mitotic centrosome proteins and complexes";"Anchoring of the basal body to the plasma membrane";"Ub-specific processing proteases"
XP_046410884.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_046419695.1	1	Reactome: R-HSA-77289	"Mitochondrial Fatty Acid Beta-Oxidation"
XP_046410745.1	4	Reactome: R-HSA-112308;Reactome: R-HSA-5576893;Reactome: R-HSA-419037;Reactome: R-HSA-5576892	"Presynaptic depolarization and calcium channel opening";"Phase 2 - plateau phase";"NCAM1 interactions";"Phase 0 - rapid depolarisation"
XP_046410733.1	4	Reactome: R-HSA-112308;Reactome: R-HSA-5576893;Reactome: R-HSA-419037;Reactome: R-HSA-5576892	"Presynaptic depolarization and calcium channel opening";"Phase 2 - plateau phase";"NCAM1 interactions";"Phase 0 - rapid depolarisation"
XP_046424284.1	2	Reactome: R-HSA-2142691;Reactome: R-HSA-2142700	"Synthesis of Leukotrienes (LT) and Eoxins (EX)";"Synthesis of Lipoxins (LX)"
XP_046424328.1	1	Reactome: R-HSA-499943	"Interconversion of nucleotide di- and triphosphates"
XP_046426440.1	3	Reactome: R-HSA-5696400;Reactome: R-HSA-6782135;Reactome: R-HSA-5696395	"Dual Incision in GG-NER";"Dual incision in TC-NER";"Formation of Incision Complex in GG-NER"
XP_046412371.1	32	Reactome: R-HSA-167242;Reactome: R-HSA-674695;Reactome: R-HSA-167200;Reactome: R-HSA-77075;Reactome: R-HSA-6796648;Reactome: R-HSA-167290;Reactome: R-HSA-6803529;Reactome: R-HSA-167152;Reactome: R-HSA-167172;Reactome: R-HSA-73779;Reactome: R-HSA-167160;Reactome: R-HSA-75953;Reactome: R-HSA-72165;Reactome: R-HSA-167246;Reactome: R-HSA-167238;Reactome: R-HSA-73776;Reactome: R-HSA-72086;Reactome: R-HSA-168325;Reactome: R-HSA-9018519;Reactome: R-HSA-8851708;Reactome: R-HSA-167161;Reactome: R-HSA-76042;Reactome: R-HSA-72203;Reactome: R-HSA-75955;Reactome: R-HSA-112382;Reactome: R-HSA-72163;Reactome: R-HSA-167243;Reactome: R-HSA-167158;Reactome: R-HSA-167287;Reactome: R-HSA-167162;Reactome: R-HSA-6807505;Reactome: R-HSA-113418	"Abortive elongation of HIV-1 transcript in the absence of Tat";"RNA Polymerase II Pre-transcription Events";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Pol II CTD phosphorylation and interaction with CE";"TP53 Regulates Transcription of DNA Repair Genes";"Pausing and recovery of HIV elongation";"FGFR2 alternative splicing";"Formation of HIV elongation complex in the absence of HIV Tat";"Transcription of the HIV genome";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"RNA Polymerase II Transcription Initiation";"mRNA Splicing - Minor Pathway";"Tat-mediated elongation of the HIV-1 transcript";"Pausing and recovery of Tat-mediated HIV elongation";"RNA Polymerase II Promoter Escape";"mRNA Capping";"Viral Messenger RNA Synthesis";"Estrogen-dependent gene expression";"Signaling by FGFR2 IIIa TM";"HIV Transcription Initiation";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Processing of Capped Intron-Containing Pre-mRNA";"RNA Polymerase II Transcription Elongation";"Formation of RNA Pol II elongation complex";"mRNA Splicing - Major Pathway";"Tat-mediated HIV elongation arrest and recovery";"Formation of the HIV-1 Early Elongation Complex";"HIV elongation arrest and recovery";"RNA Polymerase II HIV Promoter Escape";"RNA polymerase II transcribes snRNA genes";"Formation of the Early Elongation Complex"
XP_046433778.1	1	Reactome: R-HSA-203754	"NOSIP mediated eNOS trafficking"
XP_046417802.1	1	Reactome: R-HSA-2022377	"Metabolism of Angiotensinogen to Angiotensins"
XP_046419001.1	2	Reactome: R-HSA-5357956;Reactome: R-HSA-5357905	"TNFR1-induced NFkappaB signaling pathway";"Regulation of TNFR1 signaling"
XP_046418884.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_046423134.1	3	Reactome: R-HSA-8868766;Reactome: R-HSA-6784531;Reactome: R-HSA-6785470	"rRNA processing in the mitochondrion";"tRNA processing in the nucleus";"tRNA processing in the mitochondrion"
XP_046431953.1	14	KEGG: 00280+2.6.1.42;KEGG: 00290+2.6.1.42;KEGG: 00270+2.6.1.42;KEGG: 00966+2.6.1.42;MetaCyc: PWY-5101;MetaCyc: PWY-5104;MetaCyc: PWY-5057;MetaCyc: PWY-5103;Reactome: R-HSA-70895;MetaCyc: PWY-5078;MetaCyc: PWY-7767;MetaCyc: PWY-5076;KEGG: 00770+2.6.1.42;MetaCyc: PWY-5108	"Valine, leucine and isoleucine degradation";"Valine, leucine and isoleucine biosynthesis";"Cysteine and methionine metabolism";"Glucosinolate biosynthesis";"L-isoleucine biosynthesis II";"L-isoleucine biosynthesis IV";"L-valine degradation II";"L-isoleucine biosynthesis III";"Branched-chain amino acid catabolism";"L-isoleucine degradation II";"L-leucine degradation IV (Stickland reaction)";"L-leucine degradation III";"Pantothenate and CoA biosynthesis";"L-isoleucine biosynthesis V"
XP_046420357.1	2	Reactome: R-HSA-5689603;Reactome: R-HSA-5696394	"UCH proteinases";"DNA Damage Recognition in GG-NER"
XP_046426120.1	1	Reactome: R-HSA-5658442	"Regulation of RAS by GAPs"
XP_046414957.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_046432283.1	5	MetaCyc: PWY-7979;KEGG: 00515+2.4.1.109;MetaCyc: PWY-7922;MetaCyc: PWY-7921;KEGG: 00514+2.4.1.109	"Protein O-mannosylation III (mammals, core M3)";"Mannose type O-glycan biosynthesis";"Protein O-mannosylation II (mammals, core M1 and core M2)";"Protein O-mannosylation I (yeast)";"Other types of O-glycan biosynthesis"
XP_046424295.1	2	Reactome: R-HSA-5628897;Reactome: R-HSA-611105	"TP53 Regulates Metabolic Genes";"Respiratory electron transport"
XP_046425344.1	1	Reactome: R-HSA-390648	"Muscarinic acetylcholine receptors"
XP_046419569.1	7	Reactome: R-HSA-2979096;Reactome: R-HSA-2691232;MetaCyc: PWY-7511;Reactome: R-HSA-2122948;Reactome: R-HSA-2894862;Reactome: R-HSA-2644606;Reactome: R-HSA-9013507	"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Constitutive Signaling by NOTCH1 HD Domain Mutants";"Protein ubiquitination";"Activated NOTCH1 Transmits Signal to the Nucleus";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH3 Activation and Transmission of Signal to the Nucleus"
XP_046412070.1	1	Reactome: R-HSA-977347	"Serine biosynthesis"
XP_046432162.1	1	Reactome: R-HSA-390522	"Striated Muscle Contraction"
XP_046433553.1	1	Reactome: R-HSA-6790901	"rRNA modification in the nucleus and cytosol"
XP_046410463.1	5	KEGG: 00270+6.3.2.3;KEGG: 00480+6.3.2.3;Reactome: R-HSA-5579006;MetaCyc: PWY-8043;Reactome: R-HSA-174403	"Cysteine and methionine metabolism";"Glutathione metabolism";"Defective GSS causes Glutathione synthetase deficiency (GSS deficiency)";"Ophthalmate biosynthesis";"Glutathione synthesis and recycling"
XP_046410831.1	6	Reactome: R-HSA-452723;Reactome: R-HSA-6785807;Reactome: R-HSA-8986944;Reactome: R-HSA-3769402;Reactome: R-HSA-2892245;Reactome: R-HSA-2892247	"Transcriptional regulation of pluripotent stem cells";"Interleukin-4 and Interleukin-13 signaling";"Transcriptional Regulation by MECP2";"Deactivation of the beta-catenin transactivating complex";"POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation";"POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation"
XP_046426429.1	9	Reactome: R-HSA-5627083;Reactome: R-HSA-382556;Reactome: R-HSA-9646399;Reactome: R-HSA-5678895;Reactome: R-HSA-8856828;Reactome: R-HSA-8856825;Reactome: R-HSA-9615710;Reactome: R-HSA-9613829;Reactome: R-HSA-5689880	"RHO GTPases regulate CFTR trafficking";"ABC-family proteins mediated transport";"Aggrephagy";"Defective CFTR causes cystic fibrosis";"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis";"Late endosomal microautophagy";"Chaperone Mediated Autophagy";"Ub-specific processing proteases"
XP_046414958.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_046434994.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046416354.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046428665.1	4	KEGG: 00564+3.1.1.32;MetaCyc: PWY-6803;MetaCyc: PWY-8051;KEGG: 00592+3.1.1.32	"Glycerophospholipid metabolism";"Phosphatidylcholine acyl editing";"Anandamide biosynthesis I";"alpha-Linolenic acid metabolism"
XP_046414473.1	2	KEGG: 00073+2.3.1.20;KEGG: 00561+2.3.1.20	"Cutin, suberine and wax biosynthesis";"Glycerolipid metabolism"
XP_046433469.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_046423599.1	3	Reactome: R-HSA-381038;Reactome: R-HSA-8957275;Reactome: R-HSA-381426	"XBP1(S) activates chaperone genes";"Post-translational protein phosphorylation";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"
XP_046431584.1	2	Reactome: R-HSA-5576892;Reactome: R-HSA-5576893	"Phase 0 - rapid depolarisation";"Phase 2 - plateau phase"
XP_046423271.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046430202.1	2	Reactome: R-HSA-3928665;Reactome: R-HSA-2682334	"EPH-ephrin mediated repulsion of cells";"EPH-Ephrin signaling"
XP_046424600.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046426124.1	1	Reactome: R-HSA-5658442	"Regulation of RAS by GAPs"
XP_046433559.1	3	Reactome: R-HSA-1358803;Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Downregulation of ERBB2:ERBB3 signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_046436157.1	6	KEGG: 00561+2.7.1.107;MetaCyc: PWY-7039;MetaCyc: PWY-7817;KEGG: 00564+2.7.1.107;Reactome: R-HSA-114508;KEGG: 04070+2.7.1.107	"Glycerolipid metabolism";"Phosphatidate metabolism, as a signaling molecule";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Glycerophospholipid metabolism";"Effects of PIP2 hydrolysis";"Phosphatidylinositol signaling system"
XP_046430940.1	1	Reactome: R-HSA-373753	"Nephrin family interactions"
XP_046433022.1	10	Reactome: R-HSA-2894862;Reactome: R-HSA-2197563;Reactome: R-HSA-9013695;Reactome: R-HSA-8941856;Reactome: R-HSA-1912408;Reactome: R-HSA-210744;Reactome: R-HSA-2122947;Reactome: R-HSA-2644606;Reactome: R-HSA-9013508;Reactome: R-HSA-350054	"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"NOTCH2 intracellular domain regulates transcription";"NOTCH4 Intracellular Domain Regulates Transcription";"RUNX3 regulates NOTCH signaling";"Pre-NOTCH Transcription and Translation";"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"NOTCH1 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH3 Intracellular Domain Regulates Transcription";"Notch-HLH transcription pathway"
XP_046425168.1	1	Reactome: R-HSA-69231	"Cyclin D associated events in G1"
XP_046417212.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046409667.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_046432158.1	1	Reactome: R-HSA-390522	"Striated Muscle Contraction"
XP_046434419.1	1	Reactome: R-HSA-3295583	"TRP channels"
XP_046428332.1	2	Reactome: R-HSA-5339700;Reactome: R-HSA-4641265	"TCF7L2 mutants don't bind CTBP";"Repression of WNT target genes"
XP_046414581.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046423103.1	1	Reactome: R-HSA-3299685	"Detoxification of Reactive Oxygen Species"
XP_046419849.1	2	Reactome: R-HSA-390471;Reactome: R-HSA-1660662	"Association of TriC/CCT with target proteins during biosynthesis";"Glycosphingolipid metabolism"
XP_046413338.1	5	KEGG: 00520+2.7.1.6;KEGG: 00052+2.7.1.6;MetaCyc: PWY-6527;MetaCyc: PWY-6317;MetaCyc: PWY-3821	"Amino sugar and nucleotide sugar metabolism";"Galactose metabolism";"Stachyose degradation";"D-galactose degradation I (Leloir pathway)";"D-galactose detoxification"
XP_046416737.1	6	Reactome: R-HSA-4411364;Reactome: R-HSA-4086398;Reactome: R-HSA-3769402;Reactome: R-HSA-4641265;Reactome: R-HSA-201722;Reactome: R-HSA-8951430	"Binding of TCF/LEF:CTNNB1 to target gene promoters";"Ca2+ pathway";"Deactivation of the beta-catenin transactivating complex";"Repression of WNT target genes";"Formation of the beta-catenin:TCF transactivating complex";"RUNX3 regulates WNT signaling"
XP_046430656.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_046423229.1	20	Reactome: R-HSA-9033241;KEGG: 00410+1.3.3.6;MetaCyc: PWY-5136;KEGG: 00640+1.3.3.6;KEGG: 00592+1.3.3.6;MetaCyc: PWY-735;MetaCyc: PWY-6837;MetaCyc: PWY-7338;KEGG: 00071+1.3.3.6;MetaCyc: PWY-7291;MetaCyc: PWY-7858;MetaCyc: PWY-6920;MetaCyc: PWY-7574;MetaCyc: PWY-7337;MetaCyc: PWY-7288;MetaCyc: PWY-7340;MetaCyc: PWY-7606;MetaCyc: PWY-7726;MetaCyc: PWY-7007;MetaCyc: PWY-7854	"Peroxisomal protein import";"beta-Alanine metabolism";"Fatty acid beta-oxidation II (plant peroxisome)";"Propanoate metabolism";"alpha-Linolenic acid metabolism";"Jasmonic acid biosynthesis";"Fatty acid beta-oxidation V (unsaturated, odd number, di-isomerase-dependent)";"10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast)";"Fatty acid degradation";"Oleate beta-oxidation (isomerase-dependent, yeast)";"(5Z)-dodecenoate biosynthesis II";"6-gingerol analog biosynthesis (engineered)";"Propanoyl-coa degradation II";"10-cis-heptadecenoyl-CoA degradation (yeast)";"Fatty acid beta-oxidation VII (yeast peroxisome)";"9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast)";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"Methyl ketone biosynthesis (engineered)";"Crotonyl-coa/ethylmalonyl-coa/hydroxybutyryl-coa cycle (engineered)"
XP_046424945.1	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
XP_046415766.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_046415912.1	2	Reactome: R-HSA-1989781;Reactome: R-HSA-381340	"PPARA activates gene expression";"Transcriptional regulation of white adipocyte differentiation"
XP_046430021.1	6	Reactome: R-HSA-6791226;Reactome: R-HSA-450385;Reactome: R-HSA-429958;Reactome: R-HSA-380994;Reactome: R-HSA-450604;Reactome: R-HSA-450513	"Major pathway of rRNA processing in the nucleolus and cytosol";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"mRNA decay by 3' to 5' exoribonuclease";"ATF4 activates genes in response to endoplasmic reticulum stress";"KSRP (KHSRP) binds and destabilizes mRNA";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA"
XP_046419605.1	7	MetaCyc: PWY-3385;Reactome: R-HSA-1483213;MetaCyc: PWY-7886;KEGG: 00564+2.7.1.32+2.7.1.82;MetaCyc: PWY-7818;MetaCyc: PWY-7782;Reactome: R-HSA-1483191	"Choline biosynthesis I";"Synthesis of PE";"Cell-surface glycoconjugate-linked phosphocholine biosynthesis";"Glycerophospholipid metabolism";"Type IV lipoteichoic acid biosynthesis (S. pneumoniae)";"Plasmalogen biosynthesis";"Synthesis of PC"
XP_046415966.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046428228.1	1	Reactome: R-HSA-83936	"Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"
XP_046424077.1	11	Reactome: R-HSA-5620912;Reactome: R-HSA-380270;Reactome: R-HSA-3371497;Reactome: R-HSA-6807878;Reactome: R-HSA-8854518;Reactome: R-HSA-380284;Reactome: R-HSA-2132295;Reactome: R-HSA-2565942;Reactome: R-HSA-380320;Reactome: R-HSA-380259;Reactome: R-HSA-6811436	"Anchoring of the basal body to the plasma membrane";"Recruitment of mitotic centrosome proteins and complexes";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-mediated anterograde transport";"AURKA Activation by TPX2";"Loss of proteins required for interphase microtubule organization from the centrosome";"MHC class II antigen presentation";"Regulation of PLK1 Activity at G2/M Transition";"Recruitment of NuMA to mitotic centrosomes";"Loss of Nlp from mitotic centrosomes";"COPI-independent Golgi-to-ER retrograde traffic"
XP_046418363.1	1	Reactome: R-HSA-6790901	"rRNA modification in the nucleus and cytosol"
XP_046432188.1	1	Reactome: R-HSA-1296052	"Ca2+ activated K+ channels"
XP_046410693.1	1	Reactome: R-HSA-1474228	"Degradation of the extracellular matrix"
XP_046433645.1	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
XP_046413925.1	4	Reactome: R-HSA-5696394;Reactome: R-HSA-8856825;Reactome: R-HSA-8951664;Reactome: R-HSA-6781823	"DNA Damage Recognition in GG-NER";"Cargo recognition for clathrin-mediated endocytosis";"Neddylation";"Formation of TC-NER Pre-Incision Complex"
XP_046418352.1	5	Reactome: R-HSA-1834941;Reactome: R-HSA-3270619;Reactome: R-HSA-3249367;Reactome: R-HSA-3134975;Reactome: R-HSA-6798695	"STING mediated induction of host immune responses";"IRF3-mediated induction of type I IFN";"STAT6-mediated induction of chemokines";"Regulation of innate immune responses to cytosolic DNA";"Neutrophil degranulation"
XP_046420668.1	2	KEGG: 00030+2.7.6.1;KEGG: 00230+2.7.6.1	"Pentose phosphate pathway";"Purine metabolism"
XP_046426292.1	2	Reactome: R-HSA-749476;Reactome: R-HSA-73980	"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Termination"
XP_046433531.1	2	Reactome: R-HSA-446199;Reactome: R-HSA-4755609	"Synthesis of Dolichyl-phosphate";"Defective DHDDS causes retinitis pigmentosa 59"
XP_046433844.1	1	Reactome: R-HSA-1474228	"Degradation of the extracellular matrix"
XP_046417178.1	9	Reactome: R-HSA-381340;Reactome: R-HSA-2426168;Reactome: R-HSA-2151201;Reactome: R-HSA-1368108;Reactome: R-HSA-1989781;Reactome: R-HSA-400253;Reactome: R-HSA-1368082;Reactome: R-HSA-191859;Reactome: R-HSA-400206	"Transcriptional regulation of white adipocyte differentiation";"Activation of gene expression by SREBF (SREBP)";"Transcriptional activation of mitochondrial biogenesis";"BMAL1:CLOCK,NPAS2 activates circadian gene expression";"PPARA activates gene expression";"Circadian Clock";"RORA activates gene expression";"snRNP Assembly";"Regulation of lipid metabolism by PPARalpha"
XP_046426572.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046423711.1	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
XP_046430861.1	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
XP_046414981.1	8	Reactome: R-HSA-1222556;Reactome: R-HSA-917977;Reactome: R-HSA-983712;Reactome: R-HSA-77387;Reactome: R-HSA-9639288;Reactome: R-HSA-182218;Reactome: R-HSA-9636467;Reactome: R-HSA-167590	"ROS and RNS production in phagocytes";"Transferrin endocytosis and recycling";"Ion channel transport";"Insulin receptor recycling";"Amino acids regulate mTORC1";"Nef Mediated CD8 Down-regulation";"Blockage of phagosome acidification";"Nef Mediated CD4 Down-regulation"
XP_046421014.1	6	MetaCyc: PWY-6733;Reactome: R-HSA-9640463;MetaCyc: PWY-7656;KEGG: 00073+1.2.1.84;MetaCyc: PWY-5884;MetaCyc: PWY-7782	"Sporopollenin precursors biosynthesis";"Wax biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax esters biosynthesis I";"Plasmalogen biosynthesis"
XP_046425991.1	4	Reactome: R-HSA-6781823;Reactome: R-HSA-8951664;Reactome: R-HSA-8856825;Reactome: R-HSA-5696394	"Formation of TC-NER Pre-Incision Complex";"Neddylation";"Cargo recognition for clathrin-mediated endocytosis";"DNA Damage Recognition in GG-NER"
XP_046413343.1	11	MetaCyc: PWY-6859;KEGG: 00900+5.3.3.2;MetaCyc: PWY-7102;MetaCyc: PWY-7560;MetaCyc: PWY-7524;Reactome: R-HSA-191273;MetaCyc: PWY-922;MetaCyc: PWY-6383;MetaCyc: PWY-6174;MetaCyc: PWY-5123;MetaCyc: PWY-7391	"All-trans-farnesol biosynthesis";"Terpenoid backbone biosynthesis";"Bisabolene biosynthesis (engineered)";"Methylerythritol phosphate pathway II";"Mevalonate pathway III (archaea)";"Cholesterol biosynthesis";"Mevalonate pathway I";"Mono-trans, poly-cis decaprenyl phosphate biosynthesis";"Mevalonate pathway II (archaea)";"Trans, trans-farnesyl diphosphate biosynthesis";"Isoprene biosynthesis II (engineered)"
XP_046415815.1	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
XP_046427203.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046421222.1	2	Reactome: R-HSA-1483191;Reactome: R-HSA-425366	"Synthesis of PC";"Transport of bile salts and organic acids, metal ions and amine compounds"
XP_046423188.1	1	Reactome: R-HSA-418886	"Netrin mediated repulsion signals"
XP_046436435.1	5	KEGG: 04150+2.7.11.24;Reactome: R-HSA-2871796;Reactome: R-HSA-450341;Reactome: R-HSA-450321;Reactome: R-HSA-2559580	"mTOR signaling pathway";"FCERI mediated MAPK activation";"Activation of the AP-1 family of transcription factors";"JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1";"Oxidative Stress Induced Senescence"
XP_046435287.1	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
XP_046434587.1	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
XP_046413626.1	2	Reactome: R-HSA-5663213;Reactome: R-HSA-2029482	"RHO GTPases Activate WASPs and WAVEs";"Regulation of actin dynamics for phagocytic cup formation"
XP_046414207.1	3	MetaCyc: PWY-2161B;Reactome: R-HSA-6798695;KEGG: 00790+3.4.19.9	"Glutamate removal from folates";"Neutrophil degranulation";"Folate biosynthesis"
XP_046413226.1	1	Reactome: R-HSA-70221	"Glycogen breakdown (glycogenolysis)"
XP_046435533.1	2	Reactome: R-HSA-2151201;Reactome: R-HSA-400253	"Transcriptional activation of mitochondrial biogenesis";"Circadian Clock"
XP_046435452.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046431721.1	13	Reactome: R-HSA-975957;Reactome: R-HSA-6791226;Reactome: R-HSA-975956;Reactome: R-HSA-156902;Reactome: R-HSA-72764;Reactome: R-HSA-72689;Reactome: R-HSA-9633012;Reactome: R-HSA-192823;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-2408557;Reactome: R-HSA-72706;Reactome: R-HSA-1799339	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Peptide chain elongation";"Eukaryotic Translation Termination";"Formation of a pool of free 40S subunits";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Selenocysteine synthesis";"GTP hydrolysis and joining of the 60S ribosomal subunit";"SRP-dependent cotranslational protein targeting to membrane"
XP_046413894.1	6	Reactome: R-HSA-68962;Reactome: R-HSA-68949;Reactome: R-HSA-69052;Reactome: R-HSA-68867;Reactome: R-HSA-176974;Reactome: R-HSA-176187	"Activation of the pre-replicative complex";"Orc1 removal from chromatin";"Switching of origins to a post-replicative state";"Assembly of the pre-replicative complex";"Unwinding of DNA";"Activation of ATR in response to replication stress"
XP_046421855.1	1	Reactome: R-HSA-8873719	"RAB geranylgeranylation"
XP_046422996.1	1	Reactome: R-HSA-204005	"COPII-mediated vesicle transport"
XP_046432457.1	4	MetaCyc: PWY-5189;KEGG: 00860+4.2.1.75;Reactome: R-HSA-189451;MetaCyc: PWY-5188	"Tetrapyrrole biosynthesis II (from glycine)";"Porphyrin and chlorophyll metabolism";"Heme biosynthesis";"Tetrapyrrole biosynthesis I (from glutamate)"
XP_046421754.1	3	Reactome: R-HSA-5389840;Reactome: R-HSA-5368286;Reactome: R-HSA-5419276	"Mitochondrial translation elongation";"Mitochondrial translation initiation";"Mitochondrial translation termination"
XP_046433667.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046415962.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046430045.1	26	Reactome: R-HSA-5617472;Reactome: R-HSA-9617629;Reactome: R-HSA-1234158;Reactome: R-HSA-381340;Reactome: R-HSA-3134973;Reactome: R-HSA-918233;Reactome: R-HSA-9614657;Reactome: R-HSA-1989781;Reactome: R-HSA-1912408;Reactome: R-HSA-8866907;Reactome: R-HSA-933541;Reactome: R-HSA-1368082;Reactome: R-HSA-2894862;Reactome: R-HSA-9018519;Reactome: R-HSA-400253;Reactome: R-HSA-2122947;Reactome: R-HSA-3899300;Reactome: R-HSA-2644606;Reactome: R-HSA-9013508;Reactome: R-HSA-3371568;Reactome: R-HSA-210744;Reactome: R-HSA-5621575;Reactome: R-HSA-201722;Reactome: R-HSA-3214847;Reactome: R-HSA-8941856;Reactome: R-HSA-9013695	"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Regulation of FOXO transcriptional activity by acetylation";"Regulation of gene expression by Hypoxia-inducible Factor";"Transcriptional regulation of white adipocyte differentiation";"LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production";"TRAF3-dependent IRF activation pathway";"FOXO-mediated transcription of cell death genes";"PPARA activates gene expression";"Pre-NOTCH Transcription and Translation";"Activation of the TFAP2 (AP-2) family of transcription factors";"TRAF6 mediated IRF7 activation";"RORA activates gene expression";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Estrogen-dependent gene expression";"Circadian Clock";"NOTCH1 Intracellular Domain Regulates Transcription";"SUMOylation of transcription cofactors";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH3 Intracellular Domain Regulates Transcription";"Attenuation phase";"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"CD209 (DC-SIGN) signaling";"Formation of the beta-catenin:TCF transactivating complex";"HATs acetylate histones";"RUNX3 regulates NOTCH signaling";"NOTCH4 Intracellular Domain Regulates Transcription"
XP_046430594.1	24	KEGG: 04150+2.7.11.1;Reactome: R-HSA-114604;KEGG: 04151+2.7.11.1;Reactome: R-HSA-444257;KEGG: 05163+2.7.11.1;Reactome: R-HSA-2871837;Reactome: R-HSA-389357;Reactome: R-HSA-5625740;Reactome: R-HSA-2730905;KEGG: 04926+2.7.11.1;Reactome: R-HSA-9634635;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;Reactome: R-HSA-5218921;Reactome: R-HSA-354192;Reactome: R-HSA-5607764;Reactome: R-HSA-165158;Reactome: R-HSA-5674400;Reactome: R-HSA-6804757;Reactome: R-HSA-1257604;Reactome: R-HSA-392451;Reactome: R-HSA-202424;KEGG: 05165+2.7.11.1;Reactome: R-HSA-5218920	"mTOR signaling pathway";"GPVI-mediated activation cascade";"PI3K-Akt signaling pathway";"RSK activation";"Human cytomegalovirus infection";"FCERI mediated NF-kB activation";"CD28 dependent PI3K/Akt signaling";"RHO GTPases activate PKNs";"Role of LAT2/NTAL/LAB on calcium mobilization";"Relaxin signaling pathway";"Estrogen-stimulated signaling through PRKCZ";"Thermogenesis";"Human immunodeficiency virus 1 infection";"VEGFR2 mediated cell proliferation";"Integrin signaling";"CLEC7A (Dectin-1) signaling";"Activation of AKT2";"Constitutive Signaling by AKT1 E17K in Cancer";"Regulation of TP53 Degradation";"PIP3 activates AKT signaling";"G beta:gamma signalling through PI3Kgamma";"Downstream TCR signaling";"Human papillomavirus infection";"VEGFR2 mediated vascular permeability"
XP_046422966.1	18	KEGG: 00330+2.6.1.1;MetaCyc: PWY-7117;KEGG: 00220+2.6.1.1;KEGG: 00250+2.6.1.1;KEGG: 00350+2.6.1.1;KEGG: 00710+2.6.1.1;KEGG: 00270+2.6.1.1;KEGG: 00960+2.6.1.1;MetaCyc: PWY-6643;MetaCyc: PWY-6642;MetaCyc: PWY-7115;KEGG: 00360+2.6.1.1;MetaCyc: PWY-7383;KEGG: 00950+2.6.1.1;MetaCyc: PWY-5913;MetaCyc: PWY-6638;KEGG: 00400+2.6.1.1;KEGG: 00401+2.6.1.1	"Arginine and proline metabolism";"C4 photosynthetic carbon assimilation cycle, PEPCK type";"Arginine biosynthesis";"Alanine, aspartate and glutamate metabolism";"Tyrosine metabolism";"Carbon fixation in photosynthetic organisms";"Cysteine and methionine metabolism";"Tropane, piperidine and pyridine alkaloid biosynthesis";"Coenzyme M biosynthesis II";"(R)-cysteate degradation";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"Phenylalanine metabolism";"Anaerobic energy metabolism (invertebrates, cytosol)";"Isoquinoline alkaloid biosynthesis";"Partial TCA cycle (obligate autotrophs)";"Sulfolactate degradation III";"Phenylalanine, tyrosine and tryptophan biosynthesis";"Novobiocin biosynthesis"
XP_046425937.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046422694.1	2	Reactome: R-HSA-204005;Reactome: R-HSA-8876198	"COPII-mediated vesicle transport";"RAB GEFs exchange GTP for GDP on RABs"
XP_046421493.1	1	Reactome: R-HSA-2299718	"Condensation of Prophase Chromosomes"
XP_046422892.1	1	Reactome: R-HSA-427652	"Sodium-coupled phosphate cotransporters"
XP_046435455.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046418614.1	10	KEGG: 00280+2.3.3.10;MetaCyc: PWY-7524;KEGG: 00650+2.3.3.10;KEGG: 00900+2.3.3.10;KEGG: 00072+2.3.3.10;MetaCyc: PWY-7391;MetaCyc: PWY-6174;Reactome: R-HSA-1989781;MetaCyc: PWY-922;MetaCyc: PWY-7571	"Valine, leucine and isoleucine degradation";"Mevalonate pathway III (archaea)";"Butanoate metabolism";"Terpenoid backbone biosynthesis";"Synthesis and degradation of ketone bodies";"Isoprene biosynthesis II (engineered)";"Mevalonate pathway II (archaea)";"PPARA activates gene expression";"Mevalonate pathway I";"Ferrichrome A biosynthesis"
XP_046433171.1	4	Reactome: R-HSA-6811434;Reactome: R-HSA-2132295;Reactome: R-HSA-983189;Reactome: R-HSA-68884	"COPI-dependent Golgi-to-ER retrograde traffic";"MHC class II antigen presentation";"Kinesins";"Mitotic Telophase/Cytokinesis"
XP_046419320.1	6	Reactome: R-HSA-6814122;Reactome: R-HSA-390450;Reactome: R-HSA-390471;Reactome: R-HSA-389960;Reactome: R-HSA-389957;Reactome: R-HSA-5620922	"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"Folding of actin by CCT/TriC";"Association of TriC/CCT with target proteins during biosynthesis";"Formation of tubulin folding intermediates by CCT/TriC";"Prefoldin mediated transfer of substrate to CCT/TriC";"BBSome-mediated cargo-targeting to cilium"
XP_046412458.1	2	Reactome: R-HSA-70895;KEGG: 00280+1.1.1.31	"Branched-chain amino acid catabolism";"Valine, leucine and isoleucine degradation"
XP_046413261.1	7	KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1	"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Relaxin signaling pathway";"Thermogenesis";"Human cytomegalovirus infection";"mTOR signaling pathway";"PI3K-Akt signaling pathway"
XP_046413959.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046413903.1	3	KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16	"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
XP_046427528.1	1	Reactome: R-HSA-1971475	"A tetrasaccharide linker sequence is required for GAG synthesis"
XP_046410072.1	6	Reactome: R-HSA-72689;Reactome: R-HSA-156827;Reactome: R-HSA-72706;Reactome: R-HSA-72702;Reactome: R-HSA-72695;Reactome: R-HSA-72649	"Formation of a pool of free 40S subunits";"L13a-mediated translational silencing of Ceruloplasmin expression";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Ribosomal scanning and start codon recognition";"Formation of the ternary complex, and subsequently, the 43S complex";"Translation initiation complex formation"
XP_046422203.1	2	Reactome: R-HSA-8939243;Reactome: R-HSA-3214858	"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RMTs methylate histone arginines"
XP_046413168.1	1	KEGG: 00760+2.3.1.286	"Nicotinate and nicotinamide metabolism"
XP_046425701.1	1	Reactome: R-HSA-3299685	"Detoxification of Reactive Oxygen Species"
XP_046423274.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046409765.1	12	KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;Reactome: R-HSA-194840;KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;Reactome: R-HSA-193648;Reactome: R-HSA-416476;Reactome: R-HSA-418885;KEGG: 04151+2.7.11.1;Reactome: R-HSA-416482;KEGG: 04150+2.7.11.1	"Thermogenesis";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Rho GTPase cycle";"Human cytomegalovirus infection";"Relaxin signaling pathway";"NRAGE signals death through JNK";"G alpha (q) signalling events";"DCC mediated attractive signaling";"PI3K-Akt signaling pathway";"G alpha (12/13) signalling events";"mTOR signaling pathway"
XP_046433762.1	52	Reactome: R-HSA-72086;Reactome: R-HSA-73776;Reactome: R-HSA-167161;Reactome: R-HSA-8851708;Reactome: R-HSA-9018519;Reactome: R-HSA-168325;Reactome: R-HSA-75955;Reactome: R-HSA-72203;Reactome: R-HSA-76042;Reactome: R-HSA-5617472;Reactome: R-HSA-167243;Reactome: R-HSA-72163;Reactome: R-HSA-73780;Reactome: R-HSA-112382;Reactome: R-HSA-167287;Reactome: R-HSA-6781827;Reactome: R-HSA-167158;Reactome: R-HSA-5578749;Reactome: R-HSA-73762;Reactome: R-HSA-6781823;Reactome: R-HSA-167162;Reactome: R-HSA-6807505;Reactome: R-HSA-203927;Reactome: R-HSA-113418;Reactome: R-HSA-6782210;Reactome: R-HSA-76061;Reactome: R-HSA-77075;Reactome: R-HSA-6796648;Reactome: R-HSA-167200;Reactome: R-HSA-674695;Reactome: R-HSA-167242;Reactome: R-HSA-6803529;Reactome: R-HSA-1834949;Reactome: R-HSA-167152;Reactome: R-HSA-749476;Reactome: R-HSA-73772;Reactome: R-HSA-167290;Reactome: R-HSA-167172;Reactome: R-HSA-76071;Reactome: R-HSA-5601884;Reactome: R-HSA-73863;Reactome: R-HSA-73779;Reactome: R-HSA-6782135;Reactome: R-HSA-5250924;Reactome: R-HSA-167160;Reactome: R-HSA-76066;Reactome: R-HSA-167246;Reactome: R-HSA-72165;Reactome: R-HSA-427413;Reactome: R-HSA-75953;Reactome: R-HSA-167238;Reactome: R-HSA-73980	"mRNA Capping";"RNA Polymerase II Promoter Escape";"HIV Transcription Initiation";"Signaling by FGFR2 IIIa TM";"Estrogen-dependent gene expression";"Viral Messenger RNA Synthesis";"RNA Polymerase II Transcription Elongation";"Processing of Capped Intron-Containing Pre-mRNA";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Tat-mediated HIV elongation arrest and recovery";"mRNA Splicing - Major Pathway";"RNA Polymerase III Chain Elongation";"Formation of RNA Pol II elongation complex";"HIV elongation arrest and recovery";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Formation of the HIV-1 Early Elongation Complex";"Transcriptional regulation by small RNAs";"RNA Polymerase I Transcription Initiation";"Formation of TC-NER Pre-Incision Complex";"RNA Polymerase II HIV Promoter Escape";"RNA polymerase II transcribes snRNA genes";"MicroRNA (miRNA) biogenesis";"Formation of the Early Elongation Complex";"Gap-filling DNA repair synthesis and ligation in TC-NER";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Pol II CTD phosphorylation and interaction with CE";"TP53 Regulates Transcription of DNA Repair Genes";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Polymerase II Pre-transcription Events";"Abortive elongation of HIV-1 transcript in the absence of Tat";"FGFR2 alternative splicing";"Cytosolic sensors of pathogen-associated DNA";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase I Promoter Escape";"Pausing and recovery of HIV elongation";"Transcription of the HIV genome";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"PIWI-interacting RNA (piRNA) biogenesis";"RNA Polymerase I Transcription Termination";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Dual incision in TC-NER";"B-WICH complex positively regulates rRNA expression";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"Tat-mediated elongation of the HIV-1 transcript";"mRNA Splicing - Minor Pathway";"NoRC negatively regulates rRNA expression";"RNA Polymerase II Transcription Initiation";"Pausing and recovery of Tat-mediated HIV elongation";"RNA Polymerase III Transcription Termination"
XP_046434226.1	1	Reactome: R-HSA-5662702	"Melanin biosynthesis"
XP_046431725.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_046430535.1	14	KEGG: 00062+2.3.1.199;MetaCyc: PWY-7601;MetaCyc: PWY-5080;MetaCyc: PWY-7725;MetaCyc: PWY-7619;MetaCyc: PWY-7035;MetaCyc: PWY-6598;MetaCyc: PWY-7602;MetaCyc: PWY-7036;MetaCyc: PWY-8041;MetaCyc: PWY-6433;Reactome: R-HSA-75876;MetaCyc: PWY-5972;MetaCyc: PWY-7724	"Fatty acid elongation";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis I";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Juniperonate biosynthesis";"(9Z)-tricosene biosynthesis";"Sciadonate biosynthesis";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis II";"Ultra-long-chain fatty acid biosynthesis";"Hydroxylated fatty acid biosynthesis (plants)";"Synthesis of very long-chain fatty acyl-CoAs";"Stearate biosynthesis I (animals)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)"
XP_046418909.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046421268.1	4	Reactome: R-HSA-8953750;Reactome: R-HSA-69656;Reactome: R-HSA-69202;Reactome: R-HSA-1362277	"Transcriptional Regulation by E2F6";"Cyclin A:Cdk2-associated events at S phase entry";"Cyclin E associated events during G1/S transition";"Transcription of E2F targets under negative control by DREAM complex"
XP_046419929.1	8	Reactome: R-HSA-5083633;MetaCyc: PWY-7979;KEGG: 00515+2.4.1.109;Reactome: R-HSA-5083629;Reactome: R-HSA-5173105;MetaCyc: PWY-7922;KEGG: 00514+2.4.1.109;MetaCyc: PWY-7921	"Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1";"Protein O-mannosylation III (mammals, core M3)";"Mannose type O-glycan biosynthesis";"Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2";"O-linked glycosylation";"Protein O-mannosylation II (mammals, core M1 and core M2)";"Other types of O-glycan biosynthesis";"Protein O-mannosylation I (yeast)"
XP_046432852.1	2	Reactome: R-HSA-416482;Reactome: R-HSA-456926	"G alpha (12/13) signalling events";"Thrombin signalling through proteinase activated receptors (PARs)"
XP_046432536.1	5	KEGG: 00561+3.2.1.22;KEGG: 00052+3.2.1.22;MetaCyc: PWY-6527;KEGG: 00603+3.2.1.22;KEGG: 00600+3.2.1.22	"Glycerolipid metabolism";"Galactose metabolism";"Stachyose degradation";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Sphingolipid metabolism"
XP_046424799.1	12	Reactome: R-HSA-6804756;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;Reactome: R-HSA-5628897;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;Reactome: R-HSA-1632852;KEGG: 04714+2.7.11.1;Reactome: R-HSA-9619483;Reactome: R-HSA-380972	"Regulation of TP53 Activity through Phosphorylation";"Relaxin signaling pathway";"Human cytomegalovirus infection";"mTOR signaling pathway";"PI3K-Akt signaling pathway";"TP53 Regulates Metabolic Genes";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Macroautophagy";"Thermogenesis";"Activation of AMPK downstream of NMDARs";"Energy dependent regulation of mTOR by LKB1-AMPK"
XP_046416164.1	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
XP_046425225.1	1	Reactome: R-HSA-418990	"Adherens junctions interactions"
XP_046417955.1	2	Reactome: R-HSA-5357905;Reactome: R-HSA-5357956	"Regulation of TNFR1 signaling";"TNFR1-induced NFkappaB signaling pathway"
XP_046422571.1	4	Reactome: R-HSA-5693568;Reactome: R-HSA-5693579;Reactome: R-HSA-5685942;Reactome: R-HSA-5693554	"Resolution of D-loop Structures through Holliday Junction Intermediates";"Homologous DNA Pairing and Strand Exchange";"HDR through Homologous Recombination (HRR)";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)"
XP_046409303.1	1	Reactome: R-HSA-6811434	"COPI-dependent Golgi-to-ER retrograde traffic"
XP_046431182.1	2	Reactome: R-HSA-390522;Reactome: R-HSA-445355	"Striated Muscle Contraction";"Smooth Muscle Contraction"
XP_046422711.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_046410242.1	1	Reactome: R-HSA-975957	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
XP_046430009.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_046414751.1	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6784531	"Major pathway of rRNA processing in the nucleolus and cytosol";"tRNA processing in the nucleus"
XP_046409418.1	2	Reactome: R-HSA-375276;Reactome: R-HSA-416476	"Peptide ligand-binding receptors";"G alpha (q) signalling events"
XP_046413047.1	3	Reactome: R-HSA-191859;Reactome: R-HSA-6804760;Reactome: R-HSA-3214858	"snRNP Assembly";"Regulation of TP53 Activity through Methylation";"RMTs methylate histone arginines"
XP_046419628.1	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
XP_046418908.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_046419660.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046434564.1	1	Reactome: R-HSA-437239	"Recycling pathway of L1"
XP_046423239.1	10	Reactome: R-HSA-5693616;Reactome: R-HSA-5693554;Reactome: R-HSA-5685938;Reactome: R-HSA-69473;Reactome: R-HSA-6804756;Reactome: R-HSA-5693607;Reactome: R-HSA-912446;Reactome: R-HSA-5685942;Reactome: R-HSA-5693579;Reactome: R-HSA-5693568	"Presynaptic phase of homologous DNA pairing and strand exchange";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"HDR through Single Strand Annealing (SSA)";"G2/M DNA damage checkpoint";"Regulation of TP53 Activity through Phosphorylation";"Processing of DNA double-strand break ends";"Meiotic recombination";"HDR through Homologous Recombination (HRR)";"Homologous DNA Pairing and Strand Exchange";"Resolution of D-loop Structures through Holliday Junction Intermediates"
XP_046426146.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046428709.1	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_046418341.1	6	MetaCyc: PWY-7391;Reactome: R-HSA-191273;MetaCyc: PWY-6174;KEGG: 00900+2.7.1.36;MetaCyc: PWY-922;Reactome: R-HSA-2426168	"Isoprene biosynthesis II (engineered)";"Cholesterol biosynthesis";"Mevalonate pathway II (archaea)";"Terpenoid backbone biosynthesis";"Mevalonate pathway I";"Activation of gene expression by SREBF (SREBP)"
XP_046415428.1	6	Reactome: R-HSA-210500;Reactome: R-HSA-181429;Reactome: R-HSA-388844;Reactome: R-HSA-212676;Reactome: R-HSA-181430;Reactome: R-HSA-264642	"Glutamate Neurotransmitter Release Cycle";"Serotonin Neurotransmitter Release Cycle";"Receptor-type tyrosine-protein phosphatases";"Dopamine Neurotransmitter Release Cycle";"Norepinephrine Neurotransmitter Release Cycle";"Acetylcholine Neurotransmitter Release Cycle"
XP_046431431.1	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
XP_046435708.1	2	Reactome: R-HSA-2142753;KEGG: 00970+6.3.5.7	"Arachidonic acid metabolism";"Aminoacyl-tRNA biosynthesis"
XP_046430495.1	1	Reactome: R-HSA-427359	"SIRT1 negatively regulates rRNA expression"
XP_046412773.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_046416590.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046426121.1	1	Reactome: R-HSA-5658442	"Regulation of RAS by GAPs"
XP_046414622.1	7	Reactome: R-HSA-8964208;Reactome: R-HSA-2160456;KEGG: 00790+1.14.16.1;KEGG: 00360+1.14.16.1;MetaCyc: PWY-7158;KEGG: 00400+1.14.16.1;MetaCyc: PWY-6134	"Phenylalanine metabolism";"Phenylketonuria";"Folate biosynthesis";"Phenylalanine metabolism";"L-phenylalanine degradation V";"Phenylalanine, tyrosine and tryptophan biosynthesis";"L-tyrosine biosynthesis IV"
XP_046431003.1	4	KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16;Reactome: R-HSA-180024;KEGG: 05235+3.1.3.16	"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation";"DARPP-32 events";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
XP_046431709.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046420366.1	3	MetaCyc: PWY-5963;Reactome: R-HSA-947581;KEGG: 00790+2.8.1.9	"Thio-molybdenum cofactor biosynthesis";"Molybdenum cofactor biosynthesis";"Folate biosynthesis"
XP_046433088.1	3	Reactome: R-HSA-375276;Reactome: R-HSA-416476;Reactome: R-HSA-881907	"Peptide ligand-binding receptors";"G alpha (q) signalling events";"Gastrin-CREB signalling pathway via PKC and MAPK"
XP_046419552.1	2	KEGG: 00983+3.6.1.23;KEGG: 00240+3.6.1.23	"Drug metabolism - other enzymes";"Pyrimidine metabolism"
XP_046428576.1	3	Reactome: R-HSA-193648;Reactome: R-HSA-416482;Reactome: R-HSA-194840	"NRAGE signals death through JNK";"G alpha (12/13) signalling events";"Rho GTPase cycle"
XP_046417397.1	2	KEGG: 00627+3.6.1.7;KEGG: 00620+3.6.1.7	"Aminobenzoate degradation";"Pyruvate metabolism"
XP_046426427.1	9	Reactome: R-HSA-9615710;Reactome: R-HSA-8856825;Reactome: R-HSA-9613829;Reactome: R-HSA-5689880;Reactome: R-HSA-5627083;Reactome: R-HSA-382556;Reactome: R-HSA-9646399;Reactome: R-HSA-5678895;Reactome: R-HSA-8856828	"Late endosomal microautophagy";"Cargo recognition for clathrin-mediated endocytosis";"Chaperone Mediated Autophagy";"Ub-specific processing proteases";"RHO GTPases regulate CFTR trafficking";"ABC-family proteins mediated transport";"Aggrephagy";"Defective CFTR causes cystic fibrosis";"Clathrin-mediated endocytosis"
XP_046413658.1	1	Reactome: R-HSA-9609523	"Insertion of tail-anchored proteins into the endoplasmic reticulum membrane"
XP_046433135.1	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
XP_046412336.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_046420063.1	1	Reactome: R-HSA-6793080	"rRNA modification in the mitochondrion"
XP_046413984.1	8	KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04151+2.7.11.1;Reactome: R-HSA-2028269;KEGG: 04150+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04714+2.7.11.1	"Relaxin signaling pathway";"Human cytomegalovirus infection";"PI3K-Akt signaling pathway";"Signaling by Hippo";"mTOR signaling pathway";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Thermogenesis"
XP_046423913.1	1	Reactome: R-HSA-162658	"Golgi Cisternae Pericentriolar Stack Reorganization"
XP_046433908.1	1	Reactome: R-HSA-8876725	"Protein methylation"
XP_046435658.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-5628897	"Respiratory electron transport";"TP53 Regulates Metabolic Genes"
XP_046434702.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_046433451.1	2	Reactome: R-HSA-8866423;Reactome: R-HSA-8963888	"VLDL assembly";"Chylomicron assembly"
XP_046425409.1	2	Reactome: R-HSA-8856828;Reactome: R-HSA-8856825	"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis"
XP_046433334.1	5	Reactome: R-HSA-9614657;Reactome: R-HSA-381183;Reactome: R-HSA-2426168;Reactome: R-HSA-380994;Reactome: R-HSA-1989781	"FOXO-mediated transcription of cell death genes";"ATF6 (ATF6-alpha) activates chaperone genes";"Activation of gene expression by SREBF (SREBP)";"ATF4 activates genes in response to endoplasmic reticulum stress";"PPARA activates gene expression"
XP_046425936.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046412285.1	4	MetaCyc: PWY-6483;MetaCyc: PWY-7119;Reactome: R-HSA-1660662;KEGG: 00600+3.5.1.23	"Ceramide degradation (generic)";"Ceramide and sphingolipid recycling and degradation (yeast)";"Glycosphingolipid metabolism";"Sphingolipid metabolism"
XP_046435657.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
XP_046424467.1	1	Reactome: R-HSA-1483148	"Synthesis of PG"
XP_046433592.1	2	Reactome: R-HSA-5619061;Reactome: R-HSA-425397	"Defective SLC33A1 causes spastic paraplegia 42 (SPG42)";"Transport of vitamins, nucleosides, and related molecules"
XP_046410422.1	3	Reactome: R-HSA-212436;Reactome: R-HSA-381340;Reactome: R-HSA-1989781	"Generic Transcription Pathway";"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression"
XP_046430689.1	3	Reactome: R-HSA-9033807;MetaCyc: PWY-7833;MetaCyc: PWY-7831	"ABO blood group biosynthesis";"Biosynthesis of Lewis epitopes (H. pylori)";"ABH and Lewis epitopes biosynthesis from type 2 precursor disaccharide"
XP_046430149.1	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
XP_046420519.1	1	Reactome: R-HSA-426117	"Cation-coupled Chloride cotransporters"
XP_046414491.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046418949.1	1	Reactome: R-HSA-389977	"Post-chaperonin tubulin folding pathway"
XP_046415146.1	2	Reactome: R-HSA-3359473;Reactome: R-HSA-196741	"Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD";"Cobalamin (Cbl, vitamin B12) transport and metabolism"
XP_046419688.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_046425110.1	2	Reactome: R-HSA-376176;Reactome: R-HSA-202433	"Signaling by ROBO receptors";"Generation of second messenger molecules"
XP_046426334.1	1	Reactome: R-HSA-5601884	"PIWI-interacting RNA (piRNA) biogenesis"
XP_046410752.1	10	Reactome: R-HSA-8856825;Reactome: R-HSA-8875360;Reactome: R-HSA-5689880;Reactome: R-HSA-432720;Reactome: R-HSA-182971;Reactome: R-HSA-9636383;Reactome: R-HSA-8856828;Reactome: R-HSA-9635644;Reactome: R-HSA-917729;Reactome: R-HSA-6807004	"Cargo recognition for clathrin-mediated endocytosis";"InlB-mediated entry of Listeria monocytogenes into host cell";"Ub-specific processing proteases";"Lysosome Vesicle Biogenesis";"EGFR downregulation";"Prevention of phagosomal-lysosomal fusion";"Clathrin-mediated endocytosis";"Inhibition of membrane repair";"Endosomal Sorting Complex Required For Transport (ESCRT)";"Negative regulation of MET activity"
XP_046422142.1	6	MetaCyc: PWY-5067;MetaCyc: PWY-622;MetaCyc: PWY-7900;Reactome: R-HSA-189085;KEGG: 00500+3.2.1.1;KEGG: 00500+2.4.1.18	"Glycogen biosynthesis II (from UDP-D-Glucose)";"Starch biosynthesis";"Glycogen biosynthesis III (from alpha-maltose 1-phosphate)";"Digestion of dietary carbohydrate";"Starch and sucrose metabolism";"Starch and sucrose metabolism"
XP_046410018.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_046416391.1	2	Reactome: R-HSA-5576893;Reactome: R-HSA-5576892	"Phase 2 - plateau phase";"Phase 0 - rapid depolarisation"
XP_046428634.1	1	Reactome: R-HSA-5689603	"UCH proteinases"
XP_046426489.1	2	Reactome: R-HSA-5619039;Reactome: R-HSA-426117	"Defective SLC12A6 causes agenesis of the corpus callosum, with peripheral neuropathy (ACCPN)";"Cation-coupled Chloride cotransporters"
XP_046433211.1	3	Reactome: R-HSA-381426;Reactome: R-HSA-8957275;Reactome: R-HSA-5362798	"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"Post-translational protein phosphorylation";"Release of Hh-Np from the secreting cell"
XP_046431694.1	1	Reactome: R-HSA-1237044	"Erythrocytes take up carbon dioxide and release oxygen"
XP_046422752.1	1	Reactome: R-HSA-156584	"Cytosolic sulfonation of small molecules"
XP_046433935.1	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
XP_046428976.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_046413022.1	1	Reactome: R-HSA-83936	"Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"
XP_046411078.1	3	Reactome: R-HSA-381340;Reactome: R-HSA-1989781;Reactome: R-HSA-9018519	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression";"Estrogen-dependent gene expression"
XP_046412793.1	2	KEGG: 00480+1.11.1.15;Reactome: R-HSA-3299685	"Glutathione metabolism";"Detoxification of Reactive Oxygen Species"
XP_046435889.1	3	Reactome: R-HSA-445095;Reactome: R-HSA-8963901;Reactome: R-HSA-6807878	"Interaction between L1 and Ankyrins";"Chylomicron remodeling";"COPI-mediated anterograde transport"
XP_046429640.1	29	Reactome: R-HSA-75953;Reactome: R-HSA-427413;Reactome: R-HSA-167162;Reactome: R-HSA-167246;Reactome: R-HSA-6781823;Reactome: R-HSA-6782210;Reactome: R-HSA-113418;Reactome: R-HSA-167158;Reactome: R-HSA-5696400;Reactome: R-HSA-6781827;Reactome: R-HSA-6782135;Reactome: R-HSA-73779;Reactome: R-HSA-167160;Reactome: R-HSA-73762;Reactome: R-HSA-76042;Reactome: R-HSA-75955;Reactome: R-HSA-167172;Reactome: R-HSA-112382;Reactome: R-HSA-73863;Reactome: R-HSA-73776;Reactome: R-HSA-674695;Reactome: R-HSA-72086;Reactome: R-HSA-6796648;Reactome: R-HSA-167200;Reactome: R-HSA-77075;Reactome: R-HSA-73772;Reactome: R-HSA-167161;Reactome: R-HSA-5696395;Reactome: R-HSA-167152	"RNA Polymerase II Transcription Initiation";"NoRC negatively regulates rRNA expression";"RNA Polymerase II HIV Promoter Escape";"Tat-mediated elongation of the HIV-1 transcript";"Formation of TC-NER Pre-Incision Complex";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Formation of the Early Elongation Complex";"Formation of the HIV-1 Early Elongation Complex";"Dual Incision in GG-NER";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Dual incision in TC-NER";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"RNA Polymerase I Transcription Initiation";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"RNA Polymerase II Transcription Elongation";"Transcription of the HIV genome";"Formation of RNA Pol II elongation complex";"RNA Polymerase I Transcription Termination";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Pre-transcription Events";"mRNA Capping";"TP53 Regulates Transcription of DNA Repair Genes";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"RNA Pol II CTD phosphorylation and interaction with CE";"RNA Polymerase I Promoter Escape";"HIV Transcription Initiation";"Formation of Incision Complex in GG-NER";"Formation of HIV elongation complex in the absence of HIV Tat"
XP_046416937.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046414763.1	19	Reactome: R-HSA-8866423;Reactome: R-HSA-8963888;Reactome: R-HSA-3000480;Reactome: R-HSA-3000497;Reactome: R-HSA-8964041;Reactome: R-HSA-3000484;Reactome: R-HSA-381426;Reactome: R-HSA-975634;Reactome: R-HSA-202733;Reactome: R-HSA-8964046;Reactome: R-HSA-3000471;Reactome: R-HSA-5686938;Reactome: R-HSA-8856825;Reactome: R-HSA-8856828;Reactome: R-HSA-432142;Reactome: R-HSA-8964026;Reactome: R-HSA-8963901;Reactome: R-HSA-8964038;Reactome: R-HSA-8957275	"VLDL assembly";"Chylomicron assembly";"Scavenging by Class A Receptors";"Scavenging by Class H Receptors";"LDL remodeling";"Scavenging by Class F Receptors";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"Retinoid metabolism and transport";"Cell surface interactions at the vascular wall";"VLDL clearance";"Scavenging by Class B Receptors";"Regulation of TLR by endogenous ligand";"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis";"Platelet sensitization by LDL";"Chylomicron clearance";"Chylomicron remodeling";"LDL clearance";"Post-translational protein phosphorylation"
XP_046422177.1	1	KEGG: 00970+6.1.1.21	"Aminoacyl-tRNA biosynthesis"
XP_046421713.1	1	Reactome: R-HSA-425410	"Metal ion SLC transporters"
XP_046413210.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046434307.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_046434245.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_046420798.1	10	Reactome: R-HSA-9613354;Reactome: R-HSA-5628897;Reactome: R-HSA-200425;Reactome: R-HSA-163680;Reactome: R-HSA-6804756;Reactome: R-HSA-1445148;Reactome: R-HSA-380972;Reactome: R-HSA-2151209;Reactome: R-HSA-9619483;Reactome: R-HSA-1632852	"Lipophagy";"TP53 Regulates Metabolic Genes";"Carnitine metabolism";"AMPK inhibits chREBP transcriptional activation activity";"Regulation of TP53 Activity through Phosphorylation";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Energy dependent regulation of mTOR by LKB1-AMPK";"Activation of PPARGC1A (PGC-1alpha) by phosphorylation";"Activation of AMPK downstream of NMDARs";"Macroautophagy"
XP_046434597.1	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046428578.1	3	Reactome: R-HSA-416482;Reactome: R-HSA-194840;Reactome: R-HSA-193648	"G alpha (12/13) signalling events";"Rho GTPase cycle";"NRAGE signals death through JNK"
XP_046431259.1	3	MetaCyc: PWY-7533;Reactome: R-HSA-2142691;Reactome: R-HSA-5423646	"Gliotoxin biosynthesis";"Synthesis of Leukotrienes (LT) and Eoxins (EX)";"Aflatoxin activation and detoxification"
XP_046413828.1	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046422423.1	2	Reactome: R-HSA-212676;Reactome: R-HSA-181429	"Dopamine Neurotransmitter Release Cycle";"Serotonin Neurotransmitter Release Cycle"
XP_046425175.1	1	Reactome: R-HSA-418990	"Adherens junctions interactions"
XP_046411128.1	1	Reactome: R-HSA-420029	"Tight junction interactions"
XP_046435728.1	1	KEGG: 00480+3.4.11.2	"Glutathione metabolism"
XP_046423748.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046412431.1	1	Reactome: R-HSA-2514853	"Condensation of Prometaphase Chromosomes"
XP_046409576.1	1	Reactome: R-HSA-6798695	"Neutrophil degranulation"
XP_046419901.1	4	Reactome: R-HSA-917977;Reactome: R-HSA-1222556;Reactome: R-HSA-77387;Reactome: R-HSA-983712	"Transferrin endocytosis and recycling";"ROS and RNS production in phagocytes";"Insulin receptor recycling";"Ion channel transport"
XP_046422546.1	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
XP_046416949.1	1	Reactome: R-HSA-9037629	"Lewis blood group biosynthesis"
XP_046430073.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_046425749.1	2	Reactome: R-HSA-3928665;Reactome: R-HSA-2682334	"EPH-ephrin mediated repulsion of cells";"EPH-Ephrin signaling"
XP_046423535.1	2	Reactome: R-HSA-71240;KEGG: 00380+1.13.11.11	"Tryptophan catabolism";"Tryptophan metabolism"
XP_046420104.1	1	Reactome: R-HSA-1632852	"Macroautophagy"
XP_046423828.1	3	MetaCyc: PWY-7533;Reactome: R-HSA-2142691;Reactome: R-HSA-5423646	"Gliotoxin biosynthesis";"Synthesis of Leukotrienes (LT) and Eoxins (EX)";"Aflatoxin activation and detoxification"
XP_046416804.1	2	Reactome: R-HSA-8949215;Reactome: R-HSA-8949664	"Mitochondrial calcium ion transport";"Processing of SMDT1"
XP_046433892.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_046426368.1	3	MetaCyc: PWY-7159;KEGG: 00860+1.3.3.3;Reactome: R-HSA-189451	"3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent)";"Porphyrin and chlorophyll metabolism";"Heme biosynthesis"
XP_046429060.1	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
XP_046434602.1	57	Reactome: R-HSA-2467813;Reactome: R-HSA-174154;Reactome: R-HSA-174184;Reactome: R-HSA-8939902;Reactome: R-HSA-6798695;Reactome: R-HSA-5607761;Reactome: R-HSA-983168;Reactome: R-HSA-5658442;Reactome: R-HSA-8939236;Reactome: R-HSA-5678895;Reactome: R-HSA-180585;Reactome: R-HSA-5610785;Reactome: R-HSA-1236978;Reactome: R-HSA-4608870;Reactome: R-HSA-4641257;Reactome: R-HSA-75815;Reactome: R-HSA-202424;Reactome: R-HSA-174084;Reactome: R-HSA-5689880;Reactome: R-HSA-8951664;Reactome: R-HSA-349425;Reactome: R-HSA-382556;Reactome: R-HSA-1169091;Reactome: R-HSA-68949;Reactome: R-HSA-2871837;Reactome: R-HSA-174178;Reactome: R-HSA-195253;Reactome: R-HSA-5358346;Reactome: R-HSA-69601;Reactome: R-HSA-69017;Reactome: R-HSA-5362768;Reactome: R-HSA-5676590;Reactome: R-HSA-9604323;Reactome: R-HSA-5668541;Reactome: R-HSA-8941858;Reactome: R-HSA-350562;Reactome: R-HSA-9010553;Reactome: R-HSA-1236974;Reactome: R-HSA-5610780;Reactome: R-HSA-450408;Reactome: R-HSA-5632684;Reactome: R-HSA-4641258;Reactome: R-HSA-211733;Reactome: R-HSA-1234176;Reactome: R-HSA-8948751;Reactome: R-HSA-69481;Reactome: R-HSA-8852276;Reactome: R-HSA-5610783;Reactome: R-HSA-5689603;Reactome: R-HSA-68827;Reactome: R-HSA-5607764;Reactome: R-HSA-187577;Reactome: R-HSA-180534;Reactome: R-HSA-174113;Reactome: R-HSA-5687128;Reactome: R-HSA-9020702;Reactome: R-HSA-8854050	"Separation of Sister Chromatids";"APC/C:Cdc20 mediated degradation of Securin";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Regulation of RUNX2 expression and activity";"Neutrophil degranulation";"Dectin-1 mediated noncanonical NF-kB signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Regulation of RAS by GAPs";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Defective CFTR causes cystic fibrosis";"Vif-mediated degradation of APOBEC3G";"GLI3 is processed to GLI3R by the proteasome";"Cross-presentation of soluble exogenous antigens (endosomes)";"Asymmetric localization of PCP proteins";"Degradation of AXIN";"Ubiquitin-dependent degradation of Cyclin D";"Downstream TCR signaling";"Autodegradation of Cdh1 by Cdh1:APC/C";"Ub-specific processing proteases";"Neddylation";"Autodegradation of the E3 ubiquitin ligase COP1";"ABC-family proteins mediated transport";"Activation of NF-kappaB in B cells";"Orc1 removal from chromatin";"FCERI mediated NF-kB activation";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Degradation of beta-catenin by the destruction complex";"Hedgehog ligand biogenesis";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"CDK-mediated phosphorylation and removal of Cdc6";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"NIK-->noncanonical NF-kB signaling";"Negative regulation of NOTCH4 signaling";"TNFR2 non-canonical NF-kB pathway";"Regulation of RUNX3 expression and activity";"Regulation of ornithine decarboxylase (ODC)";"Regulation of expression of SLITs and ROBOs";"ER-Phagosome pathway";"Degradation of GLI1 by the proteasome";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Hedgehog 'on' state";"Degradation of DVL";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of PTEN stability and activity";"G2/M Checkpoints";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Degradation of GLI2 by the proteasome";"UCH proteinases";"CDT1 association with the CDC6:ORC:origin complex";"CLEC7A (Dectin-1) signaling";"SCF(Skp2)-mediated degradation of p27/p21";"Vpu mediated degradation of CD4";"SCF-beta-TrCP mediated degradation of Emi1";"MAPK6/MAPK4 signaling";"Interleukin-1 signaling";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis"
XP_046410146.1	9	Reactome: R-HSA-416482;Reactome: R-HSA-114604;Reactome: R-HSA-4420097;Reactome: R-HSA-2871796;Reactome: R-HSA-2029482;Reactome: R-HSA-193648;Reactome: R-HSA-194840;Reactome: R-HSA-2871809;Reactome: R-HSA-5218920	"G alpha (12/13) signalling events";"GPVI-mediated activation cascade";"VEGFA-VEGFR2 Pathway";"FCERI mediated MAPK activation";"Regulation of actin dynamics for phagocytic cup formation";"NRAGE signals death through JNK";"Rho GTPase cycle";"FCERI mediated Ca+2 mobilization";"VEGFR2 mediated vascular permeability"
XP_046432976.1	1	Reactome: R-HSA-70221	"Glycogen breakdown (glycogenolysis)"
XP_046423001.1	1	Reactome: R-HSA-429947	"Deadenylation of mRNA"
XP_046422075.1	2	Reactome: R-HSA-5223345;Reactome: R-HSA-425393	"Miscellaneous transport and binding events";"Transport of inorganic cations/anions and amino acids/oligopeptides"
XP_046414884.1	5	Reactome: R-HSA-6811438;Reactome: R-HSA-204005;Reactome: R-HSA-6811434;Reactome: R-HSA-6811440;Reactome: R-HSA-6807878	"Intra-Golgi traffic";"COPII-mediated vesicle transport";"COPI-dependent Golgi-to-ER retrograde traffic";"Retrograde transport at the Trans-Golgi-Network";"COPI-mediated anterograde transport"
XP_046431576.1	6	Reactome: R-HSA-196807;MetaCyc: PWY-5381;MetaCyc: PWY-7761;KEGG: 00760+6.3.5.1;MetaCyc: PWY-5653;KEGG: 00760+6.3.1.5	"Nicotinate metabolism";"Pyridine nucleotide cycling (plants)";"NAD salvage pathway II (PNC IV cycle)";"Nicotinate and nicotinamide metabolism";"NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde";"Nicotinate and nicotinamide metabolism"
XP_046422071.1	2	Reactome: R-HSA-5223345;Reactome: R-HSA-425393	"Miscellaneous transport and binding events";"Transport of inorganic cations/anions and amino acids/oligopeptides"
XP_046418308.1	1	Reactome: R-HSA-211945	"Phase I - Functionalization of compounds"
XP_046414167.1	1	Reactome: R-HSA-8849932	"Synaptic adhesion-like molecules"
XP_046421187.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046423836.1	5	Reactome: R-HSA-5689880;Reactome: R-HSA-201681;MetaCyc: PWY-7511;Reactome: R-HSA-8948751;Reactome: R-HSA-4641257	"Ub-specific processing proteases";"TCF dependent signaling in response to WNT";"Protein ubiquitination";"Regulation of PTEN stability and activity";"Degradation of AXIN"
XP_046432019.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_046426196.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_046421296.1	26	Reactome: R-HSA-9609690;Reactome: R-HSA-2467813;Reactome: R-HSA-9648025;Reactome: R-HSA-380320;Reactome: R-HSA-6811434;Reactome: R-HSA-6807878;Reactome: R-HSA-5626467;Reactome: R-HSA-1445148;Reactome: R-HSA-389960;Reactome: R-HSA-2500257;Reactome: R-HSA-983189;Reactome: R-HSA-9619483;Reactome: R-HSA-190840;Reactome: R-HSA-8852276;Reactome: R-HSA-68877;Reactome: R-HSA-6811436;Reactome: R-HSA-9646399;Reactome: R-HSA-190861;Reactome: R-HSA-8955332;Reactome: R-HSA-9609736;Reactome: R-HSA-2132295;Reactome: R-HSA-5617833;Reactome: R-HSA-3371497;Reactome: R-HSA-5663220;Reactome: R-HSA-389977;Reactome: R-HSA-437239	"HCMV Early Events";"Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation";"Recruitment of NuMA to mitotic centrosomes";"COPI-dependent Golgi-to-ER retrograde traffic";"COPI-mediated anterograde transport";"RHO GTPases activate IQGAPs";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Formation of tubulin folding intermediates by CCT/TriC";"Resolution of Sister Chromatid Cohesion";"Kinesins";"Activation of AMPK downstream of NMDARs";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Mitotic Prometaphase";"COPI-independent Golgi-to-ER retrograde traffic";"Aggrephagy";"Gap junction assembly";"Carboxyterminal post-translational modifications of tubulin";"Assembly and cell surface presentation of NMDA receptors";"MHC class II antigen presentation";"Cilium Assembly";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"RHO GTPases Activate Formins";"Post-chaperonin tubulin folding pathway";"Recycling pathway of L1"
XP_046420478.1	2	Reactome: R-HSA-975577;Reactome: R-HSA-2022854	"N-Glycan antennae elongation";"Keratan sulfate biosynthesis"
XP_046436427.1	4	MetaCyc: PWY-7822;MetaCyc: PWY-6855;MetaCyc: PWY-6902;KEGG: 00520+3.2.1.14	"Chitin degradation III (Serratia)";"Chitin degradation I (archaea)";"Chitin degradation II (Vibrio)";"Amino sugar and nucleotide sugar metabolism"
XP_046416460.1	7	Reactome: R-HSA-2894862;Reactome: R-HSA-2122948;Reactome: R-HSA-2644606;Reactome: R-HSA-177929;Reactome: R-HSA-2691232;Reactome: R-HSA-2660826;Reactome: R-HSA-1442490	"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Activated NOTCH1 Transmits Signal to the Nucleus";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Signaling by EGFR";"Constitutive Signaling by NOTCH1 HD Domain Mutants";"Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant";"Collagen degradation"
XP_046424067.1	3	Reactome: R-HSA-114608;Reactome: R-HSA-195399;Reactome: R-HSA-194313	"Platelet degranulation";"VEGF binds to VEGFR leading to receptor dimerization";"VEGF ligand-receptor interactions"
XP_046429103.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
XP_046427317.1	2	Reactome: R-HSA-8856828;Reactome: R-HSA-8856825	"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis"
XP_046421770.1	7	KEGG: 00270+2.5.1.22;KEGG: 00480+2.5.1.22;Reactome: R-HSA-351202;KEGG: 00330+2.5.1.22;KEGG: 00480+2.5.1.16;KEGG: 00270+2.5.1.16;KEGG: 00330+2.5.1.16	"Cysteine and methionine metabolism";"Glutathione metabolism";"Metabolism of polyamines";"Arginine and proline metabolism";"Glutathione metabolism";"Cysteine and methionine metabolism";"Arginine and proline metabolism"
XP_046431743.1	9	MetaCyc: PWY-8086;KEGG: 00020+6.4.1.1;KEGG: 00720+6.4.1.1;KEGG: 00620+6.4.1.1;Reactome: R-HSA-3371599;MetaCyc: PWY-6142;Reactome: R-HSA-70263;Reactome: R-HSA-196780;MetaCyc: PWY-6146	"(S)-lactate fermentation to propanoate, acetate and hydrogen";"Citrate cycle (TCA cycle)";"Carbon fixation pathways in prokaryotes";"Pyruvate metabolism";"Defective HLCS causes multiple carboxylase deficiency";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Gluconeogenesis";"Biotin transport and metabolism";"Methanobacterium thermoautotrophicum biosynthetic metabolism"
XP_046421034.1	2	Reactome: R-HSA-418890;Reactome: R-HSA-3295583	"Role of second messengers in netrin-1 signaling";"TRP channels"
XP_046424982.1	11	Reactome: R-HSA-163359;Reactome: R-HSA-164378;Reactome: R-HSA-418555;Reactome: R-HSA-418597;Reactome: R-HSA-170660;Reactome: R-HSA-418594;Reactome: R-HSA-432040;Reactome: R-HSA-163615;Reactome: R-HSA-5610787;KEGG: 00230+4.6.1.1;Reactome: R-HSA-170670	"Glucagon signaling in metabolic regulation";"PKA activation in glucagon signalling";"G alpha (s) signalling events";"G alpha (z) signalling events";"Adenylate cyclase activating pathway";"G alpha (i) signalling events";"Vasopressin regulates renal water homeostasis via Aquaporins";"PKA activation";"Hedgehog 'off' state";"Purine metabolism";"Adenylate cyclase inhibitory pathway"
XP_046414294.1	6	Reactome: R-HSA-68877;Reactome: R-HSA-2467813;Reactome: R-HSA-9648025;Reactome: R-HSA-141444;Reactome: R-HSA-5663220;Reactome: R-HSA-2500257	"Mitotic Prometaphase";"Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"RHO GTPases Activate Formins";"Resolution of Sister Chromatid Cohesion"
XP_046433975.1	6	Reactome: R-HSA-5693568;Reactome: R-HSA-5685942;Reactome: R-HSA-5693554;Reactome: R-HSA-912446;Reactome: R-HSA-5693616;Reactome: R-HSA-5693579	"Resolution of D-loop Structures through Holliday Junction Intermediates";"HDR through Homologous Recombination (HRR)";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Meiotic recombination";"Presynaptic phase of homologous DNA pairing and strand exchange";"Homologous DNA Pairing and Strand Exchange"
XP_046410889.1	9	Reactome: R-HSA-674695;Reactome: R-HSA-73776;Reactome: R-HSA-73779;Reactome: R-HSA-167161;Reactome: R-HSA-75953;Reactome: R-HSA-76042;Reactome: R-HSA-167172;Reactome: R-HSA-167162;Reactome: R-HSA-6807505	"RNA Polymerase II Pre-transcription Events";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"HIV Transcription Initiation";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Transcription of the HIV genome";"RNA Polymerase II HIV Promoter Escape";"RNA polymerase II transcribes snRNA genes"
XP_046427211.1	5	Reactome: R-HSA-6804758;Reactome: R-HSA-73762;Reactome: R-HSA-427389;Reactome: R-HSA-3214815;Reactome: R-HSA-8943724	"Regulation of TP53 Activity through Acetylation";"RNA Polymerase I Transcription Initiation";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"HDACs deacetylate histones";"Regulation of PTEN gene transcription"
XP_046423454.1	19	Reactome: R-HSA-182971;Reactome: R-HSA-2029482;Reactome: R-HSA-5627123;Reactome: R-HSA-418885;Reactome: R-HSA-8964616;Reactome: R-HSA-5687128;Reactome: R-HSA-5663220;Reactome: R-HSA-8950505;Reactome: R-HSA-5625970;Reactome: R-HSA-983231;Reactome: R-HSA-4420097;Reactome: R-HSA-5663213;Reactome: R-HSA-114604;Reactome: R-HSA-525793;Reactome: R-HSA-5626467;Reactome: R-HSA-194840;Reactome: R-HSA-428543;Reactome: R-HSA-389359;Reactome: R-HSA-3928662	"EGFR downregulation";"Regulation of actin dynamics for phagocytic cup formation";"RHO GTPases activate PAKs";"DCC mediated attractive signaling";"G beta:gamma signalling through CDC42";"MAPK6/MAPK4 signaling";"RHO GTPases Activate Formins";"Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation";"RHO GTPases activate KTN1";"Factors involved in megakaryocyte development and platelet production";"VEGFA-VEGFR2 Pathway";"RHO GTPases Activate WASPs and WAVEs";"GPVI-mediated activation cascade";"Myogenesis";"RHO GTPases activate IQGAPs";"Rho GTPase cycle";"Inactivation of CDC42 and RAC1";"CD28 dependent Vav1 pathway";"EPHB-mediated forward signaling"
XP_046435936.1	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
XP_046429728.1	5	Reactome: R-HSA-446199;KEGG: 00510+1.3.1.94;Reactome: R-HSA-193048;Reactome: R-HSA-4755579;MetaCyc: PWY-6129	"Synthesis of Dolichyl-phosphate";"N-Glycan biosynthesis";"Androgen biosynthesis";"Defective SRD5A3 causes SRD5A3-CDG (CDG-1q) and KHRZ";"Dolichol and dolichyl phosphate biosynthesis"
XP_046417336.1	2	MetaCyc: PWY-7799;MetaCyc: PWY-7802	"Arg/N-end rule pathway (eukaryotic)";"N-end rule pathway II (prokaryotic)"
XP_046434699.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_046429541.1	1	Reactome: R-HSA-977443	"GABA receptor activation"
XP_046426016.1	20	MetaCyc: PWY-5136;KEGG: 00410+1.3.3.6;Reactome: R-HSA-9033241;MetaCyc: PWY-6837;MetaCyc: PWY-735;KEGG: 00640+1.3.3.6;KEGG: 00592+1.3.3.6;KEGG: 00071+1.3.3.6;MetaCyc: PWY-7338;MetaCyc: PWY-6920;MetaCyc: PWY-7858;MetaCyc: PWY-7291;MetaCyc: PWY-7337;MetaCyc: PWY-7574;MetaCyc: PWY-7340;MetaCyc: PWY-7288;MetaCyc: PWY-7726;MetaCyc: PWY-7606;MetaCyc: PWY-7854;MetaCyc: PWY-7007	"Fatty acid beta-oxidation II (plant peroxisome)";"beta-Alanine metabolism";"Peroxisomal protein import";"Fatty acid beta-oxidation V (unsaturated, odd number, di-isomerase-dependent)";"Jasmonic acid biosynthesis";"Propanoate metabolism";"alpha-Linolenic acid metabolism";"Fatty acid degradation";"10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast)";"6-gingerol analog biosynthesis (engineered)";"(5Z)-dodecenoate biosynthesis II";"Oleate beta-oxidation (isomerase-dependent, yeast)";"10-cis-heptadecenoyl-CoA degradation (yeast)";"Propanoyl-coa degradation II";"9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast)";"Fatty acid beta-oxidation VII (yeast peroxisome)";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"Crotonyl-coa/ethylmalonyl-coa/hydroxybutyryl-coa cycle (engineered)";"Methyl ketone biosynthesis (engineered)"
XP_046413512.1	52	Reactome: R-HSA-167172;Reactome: R-HSA-76071;Reactome: R-HSA-5601884;Reactome: R-HSA-73863;Reactome: R-HSA-76061;Reactome: R-HSA-167200;Reactome: R-HSA-6796648;Reactome: R-HSA-77075;Reactome: R-HSA-674695;Reactome: R-HSA-167242;Reactome: R-HSA-167152;Reactome: R-HSA-6803529;Reactome: R-HSA-749476;Reactome: R-HSA-1834949;Reactome: R-HSA-73772;Reactome: R-HSA-167290;Reactome: R-HSA-167246;Reactome: R-HSA-76066;Reactome: R-HSA-72165;Reactome: R-HSA-75953;Reactome: R-HSA-427413;Reactome: R-HSA-167238;Reactome: R-HSA-73980;Reactome: R-HSA-73779;Reactome: R-HSA-6782135;Reactome: R-HSA-5250924;Reactome: R-HSA-167160;Reactome: R-HSA-75955;Reactome: R-HSA-72203;Reactome: R-HSA-5617472;Reactome: R-HSA-76042;Reactome: R-HSA-167243;Reactome: R-HSA-72163;Reactome: R-HSA-73780;Reactome: R-HSA-112382;Reactome: R-HSA-72086;Reactome: R-HSA-73776;Reactome: R-HSA-167161;Reactome: R-HSA-8851708;Reactome: R-HSA-9018519;Reactome: R-HSA-168325;Reactome: R-HSA-6781823;Reactome: R-HSA-6807505;Reactome: R-HSA-167162;Reactome: R-HSA-203927;Reactome: R-HSA-6782210;Reactome: R-HSA-113418;Reactome: R-HSA-167287;Reactome: R-HSA-6781827;Reactome: R-HSA-167158;Reactome: R-HSA-5578749;Reactome: R-HSA-73762	"Transcription of the HIV genome";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"PIWI-interacting RNA (piRNA) biogenesis";"RNA Polymerase I Transcription Termination";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"TP53 Regulates Transcription of DNA Repair Genes";"RNA Pol II CTD phosphorylation and interaction with CE";"RNA Polymerase II Pre-transcription Events";"Abortive elongation of HIV-1 transcript in the absence of Tat";"Formation of HIV elongation complex in the absence of HIV Tat";"FGFR2 alternative splicing";"RNA Polymerase III Abortive And Retractive Initiation";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase I Promoter Escape";"Pausing and recovery of HIV elongation";"Tat-mediated elongation of the HIV-1 transcript";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"mRNA Splicing - Minor Pathway";"RNA Polymerase II Transcription Initiation";"NoRC negatively regulates rRNA expression";"Pausing and recovery of Tat-mediated HIV elongation";"RNA Polymerase III Transcription Termination";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"Dual incision in TC-NER";"B-WICH complex positively regulates rRNA expression";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"RNA Polymerase II Transcription Elongation";"Processing of Capped Intron-Containing Pre-mRNA";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Tat-mediated HIV elongation arrest and recovery";"mRNA Splicing - Major Pathway";"RNA Polymerase III Chain Elongation";"Formation of RNA Pol II elongation complex";"mRNA Capping";"RNA Polymerase II Promoter Escape";"HIV Transcription Initiation";"Signaling by FGFR2 IIIa TM";"Estrogen-dependent gene expression";"Viral Messenger RNA Synthesis";"Formation of TC-NER Pre-Incision Complex";"RNA polymerase II transcribes snRNA genes";"RNA Polymerase II HIV Promoter Escape";"MicroRNA (miRNA) biogenesis";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Formation of the Early Elongation Complex";"HIV elongation arrest and recovery";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Formation of the HIV-1 Early Elongation Complex";"Transcriptional regulation by small RNAs";"RNA Polymerase I Transcription Initiation"
XP_046424983.1	11	Reactome: R-HSA-164378;Reactome: R-HSA-163359;Reactome: R-HSA-418555;Reactome: R-HSA-418597;Reactome: R-HSA-170660;Reactome: R-HSA-418594;Reactome: R-HSA-432040;Reactome: R-HSA-163615;Reactome: R-HSA-5610787;KEGG: 00230+4.6.1.1;Reactome: R-HSA-170670	"PKA activation in glucagon signalling";"Glucagon signaling in metabolic regulation";"G alpha (s) signalling events";"G alpha (z) signalling events";"Adenylate cyclase activating pathway";"G alpha (i) signalling events";"Vasopressin regulates renal water homeostasis via Aquaporins";"PKA activation";"Hedgehog 'off' state";"Purine metabolism";"Adenylate cyclase inhibitory pathway"
XP_046432823.1	10	Reactome: R-HSA-111464;Reactome: R-HSA-5628897;Reactome: R-HSA-111458;Reactome: R-HSA-611105;Reactome: R-HSA-3299685;Reactome: R-HSA-111457;Reactome: R-HSA-111459;Reactome: R-HSA-9627069;Reactome: R-HSA-2151201;Reactome: R-HSA-111463	"SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes";"TP53 Regulates Metabolic Genes";"Formation of apoptosome";"Respiratory electron transport";"Detoxification of Reactive Oxygen Species";"Release of apoptotic factors from the mitochondria";"Activation of caspases through apoptosome-mediated cleavage";"Regulation of the apoptosome activity";"Transcriptional activation of mitochondrial biogenesis";"SMAC (DIABLO) binds to IAPs"
XP_046414501.1	1	Reactome: R-HSA-9609523	"Insertion of tail-anchored proteins into the endoplasmic reticulum membrane"
XP_046428181.1	3	Reactome: R-HSA-425561;Reactome: R-HSA-418359;Reactome: R-HSA-5578775	"Sodium/Calcium exchangers";"Reduction of cytosolic Ca++ levels";"Ion homeostasis"
XP_046429578.1	2	Reactome: R-HSA-5683371;Reactome: R-HSA-1369007	"Defective ABCB6 causes isolated colobomatous microphthalmia 7 (MCOPCB7)";"Mitochondrial ABC transporters"
XP_046418905.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_046426019.1	2	KEGG: 00561+2.7.1.30;MetaCyc: PWY-4261	"Glycerolipid metabolism";"Glycerol degradation I"
XP_046417447.1	4	Reactome: R-HSA-6781827;Reactome: R-HSA-6782135;Reactome: R-HSA-6781823;Reactome: R-HSA-6782210	"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Dual incision in TC-NER";"Formation of TC-NER Pre-Incision Complex";"Gap-filling DNA repair synthesis and ligation in TC-NER"
XP_046422754.1	1	Reactome: R-HSA-156584	"Cytosolic sulfonation of small molecules"
XP_046431382.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046419778.1	1	Reactome: R-HSA-390522	"Striated Muscle Contraction"
XP_046427031.1	3	MetaCyc: PWY-5491;KEGG: 00790+3.1.3.1;KEGG: 00730+3.1.3.1	"Diethylphosphate degradation";"Folate biosynthesis";"Thiamine metabolism"
XP_046426746.1	3	Reactome: R-HSA-8951664;Reactome: R-HSA-349425;MetaCyc: PWY-7511	"Neddylation";"Autodegradation of the E3 ubiquitin ligase COP1";"Protein ubiquitination"
XP_046430789.1	1	Reactome: R-HSA-6794361	"Neurexins and neuroligins"
XP_046413488.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-5628897	"Respiratory electron transport";"TP53 Regulates Metabolic Genes"
XP_046432352.1	1	Reactome: R-HSA-211981	"Xenobiotics"
XP_046434761.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_046435951.1	2	Reactome: R-HSA-917729;Reactome: R-HSA-9610379	"Endosomal Sorting Complex Required For Transport (ESCRT)";"HCMV Late Events"
XP_046427748.1	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
XP_046429448.1	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
XP_046436628.1	1	Reactome: R-HSA-5601884	"PIWI-interacting RNA (piRNA) biogenesis"
XP_046429496.1	5	KEGG: 05235+3.1.3.16;Reactome: R-HSA-176407;KEGG: 04660+3.1.3.16;Reactome: R-HSA-5687128;KEGG: 04658+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"T cell receptor signaling pathway";"MAPK6/MAPK4 signaling";"Th1 and Th2 cell differentiation"
XP_046415449.1	5	Reactome: R-HSA-199220;Reactome: R-HSA-2426168;Reactome: R-HSA-163765;Reactome: R-HSA-9029558;Reactome: R-HSA-75105	"Vitamin B5 (pantothenate) metabolism";"Activation of gene expression by SREBF (SREBP)";"ChREBP activates metabolic gene expression";"NR1H2 & NR1H3 regulate gene expression linked to lipogenesis";"Fatty acyl-CoA biosynthesis"
XP_046419684.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_046427921.1	4	Reactome: R-HSA-379726;KEGG: 00970+6.1.1.17;KEGG: 00860+6.1.1.17;MetaCyc: PWY-5188	"Mitochondrial tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis";"Porphyrin and chlorophyll metabolism";"Tetrapyrrole biosynthesis I (from glutamate)"
XP_046432828.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_046419118.1	1	Reactome: R-HSA-382556	"ABC-family proteins mediated transport"
XP_046436657.1	7	Reactome: R-HSA-76061;Reactome: R-HSA-76066;Reactome: R-HSA-76071;Reactome: R-HSA-1834949;Reactome: R-HSA-749476;Reactome: R-HSA-73980;Reactome: R-HSA-73780	"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Termination";"RNA Polymerase III Chain Elongation"
XP_046429088.1	13	MetaCyc: PWY-5123;MetaCyc: PWY-7736;KEGG: 00900+2.5.1.10+2.5.1.1;MetaCyc: PWY-7709;MetaCyc: PWY-7659;MetaCyc: PWY-6383;MetaCyc: PWY-7141;MetaCyc: PWY-5122;MetaCyc: PWY-7721;MetaCyc: PWY-7410;MetaCyc: PWY-7182;MetaCyc: PWY-7102;MetaCyc: PWY-6859	"Trans, trans-farnesyl diphosphate biosynthesis";"Stellatic acid biosynthesis";"Terpenoid backbone biosynthesis";"(3R)-linalool biosynthesis";"Viridicatumtoxin biosynthesis";"Mono-trans, poly-cis decaprenyl phosphate biosynthesis";"(3S)-linalool biosynthesis";"Geranyl diphosphate biosynthesis";"Methyl phomopsenoate biosynthesis";"Ipsdienol biosynthesis";"Linalool biosynthesis I";"Bisabolene biosynthesis (engineered)";"All-trans-farnesol biosynthesis"
XP_046422534.1	3	KEGG: 00740+3.1.3.2;MetaCyc: PWY-6348;KEGG: 00730+3.1.3.2	"Riboflavin metabolism";"Phosphate acquisition";"Thiamine metabolism"
XP_046431386.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046425260.1	2	Reactome: R-HSA-5689603;Reactome: R-HSA-5696394	"UCH proteinases";"DNA Damage Recognition in GG-NER"
XP_046423164.1	5	Reactome: R-HSA-5693607;Reactome: R-HSA-5693565;Reactome: R-HSA-69473;Reactome: R-HSA-5693571;Reactome: R-HSA-5689901	"Processing of DNA double-strand break ends";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"G2/M DNA damage checkpoint";"Nonhomologous End-Joining (NHEJ)";"Metalloprotease DUBs"
XP_046431878.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046412226.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046434545.1	1	Reactome: R-HSA-437239	"Recycling pathway of L1"
XP_046432674.1	5	Reactome: R-HSA-5610783;Reactome: R-HSA-5610787;Reactome: R-HSA-5632684;Reactome: R-HSA-5610785;Reactome: R-HSA-5610780	"Degradation of GLI2 by the proteasome";"Hedgehog 'off' state";"Hedgehog 'on' state";"GLI3 is processed to GLI3R by the proteasome";"Degradation of GLI1 by the proteasome"
XP_046432105.1	1	Reactome: R-HSA-6782315	"tRNA modification in the nucleus and cytosol"
XP_046436375.1	6	MetaCyc: PWY-7817;MetaCyc: PWY-7039;KEGG: 00561+2.7.1.107;KEGG: 04070+2.7.1.107;KEGG: 00564+2.7.1.107;Reactome: R-HSA-114508	"Type I lipoteichoic acid biosynthesis (S. aureus)";"Phosphatidate metabolism, as a signaling molecule";"Glycerolipid metabolism";"Phosphatidylinositol signaling system";"Glycerophospholipid metabolism";"Effects of PIP2 hydrolysis"
XP_046429526.1	2	Reactome: R-HSA-8876198;Reactome: R-HSA-5357905	"RAB GEFs exchange GTP for GDP on RABs";"Regulation of TNFR1 signaling"
XP_046424571.1	1	Reactome: R-HSA-8849175	"Threonine catabolism"
XP_046430537.1	6	Reactome: R-HSA-1222556;Reactome: R-HSA-77387;Reactome: R-HSA-917977;Reactome: R-HSA-9639288;Reactome: R-HSA-983712;Reactome: R-HSA-6798695	"ROS and RNS production in phagocytes";"Insulin receptor recycling";"Transferrin endocytosis and recycling";"Amino acids regulate mTORC1";"Ion channel transport";"Neutrophil degranulation"
XP_046425205.1	1	Reactome: R-HSA-418990	"Adherens junctions interactions"
XP_046415238.1	16	Reactome: R-HSA-156902;Reactome: R-HSA-72764;Reactome: R-HSA-72649;Reactome: R-HSA-975957;Reactome: R-HSA-72695;Reactome: R-HSA-1799339;Reactome: R-HSA-72689;Reactome: R-HSA-192823;Reactome: R-HSA-72702;Reactome: R-HSA-975956;Reactome: R-HSA-6791226;Reactome: R-HSA-2408557;Reactome: R-HSA-72706;Reactome: R-HSA-9633012;Reactome: R-HSA-156827;Reactome: R-HSA-9010553	"Peptide chain elongation";"Eukaryotic Translation Termination";"Translation initiation complex formation";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Formation of the ternary complex, and subsequently, the 43S complex";"SRP-dependent cotranslational protein targeting to membrane";"Formation of a pool of free 40S subunits";"Viral mRNA Translation";"Ribosomal scanning and start codon recognition";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"Selenocysteine synthesis";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs"
XP_046428580.1	3	Reactome: R-HSA-193648;Reactome: R-HSA-194840;Reactome: R-HSA-416482	"NRAGE signals death through JNK";"Rho GTPase cycle";"G alpha (12/13) signalling events"
XP_046420238.1	7	Reactome: R-HSA-1483148;MetaCyc: PWY-7039;KEGG: 00564+3.1.4.4;MetaCyc: PWY-3561;Reactome: R-HSA-2029485;Reactome: R-HSA-1483166;KEGG: 00565+3.1.4.4	"Synthesis of PG";"Phosphatidate metabolism, as a signaling molecule";"Glycerophospholipid metabolism";"Choline biosynthesis III";"Role of phospholipids in phagocytosis";"Synthesis of PA";"Ether lipid metabolism"
XP_046425723.1	13	Reactome: R-HSA-389357;Reactome: R-HSA-3371571;Reactome: R-HSA-9639288;Reactome: R-HSA-8943724;Reactome: R-HSA-5628897;Reactome: R-HSA-166208;Reactome: R-HSA-5218920;Reactome: R-HSA-1632852;Reactome: R-HSA-6804757;Reactome: R-HSA-1257604;Reactome: R-HSA-5674400;Reactome: R-HSA-380972;Reactome: R-HSA-165159	"CD28 dependent PI3K/Akt signaling";"HSF1-dependent transactivation";"Amino acids regulate mTORC1";"Regulation of PTEN gene transcription";"TP53 Regulates Metabolic Genes";"mTORC1-mediated signalling";"VEGFR2 mediated vascular permeability";"Macroautophagy";"Regulation of TP53 Degradation";"PIP3 activates AKT signaling";"Constitutive Signaling by AKT1 E17K in Cancer";"Energy dependent regulation of mTOR by LKB1-AMPK";"mTOR signalling"
XP_046431073.1	4	Reactome: R-HSA-3769402;Reactome: R-HSA-201722;Reactome: R-HSA-2122947;Reactome: R-HSA-4641265	"Deactivation of the beta-catenin transactivating complex";"Formation of the beta-catenin:TCF transactivating complex";"NOTCH1 Intracellular Domain Regulates Transcription";"Repression of WNT target genes"
XP_046419519.1	3	Reactome: R-HSA-8874081;Reactome: R-HSA-3000171;Reactome: R-HSA-3000157	"MET activates PTK2 signaling";"Non-integrin membrane-ECM interactions";"Laminin interactions"
XP_046413622.1	1	Reactome: R-HSA-6809371	"Formation of the cornified envelope"
XP_046432842.1	3	Reactome: R-HSA-72187;Reactome: R-HSA-159236;Reactome: R-HSA-73856	"mRNA 3'-end processing";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"RNA Polymerase II Transcription Termination"
XP_046435091.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_046411440.1	5	MetaCyc: PWY-7269;KEGG: 00760+2.7.1.23;MetaCyc: PWY-5083;Reactome: R-HSA-196807;MetaCyc: PWY-7268	"NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)";"Nicotinate and nicotinamide metabolism";"NAD/NADH phosphorylation and dephosphorylation";"Nicotinate metabolism";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)"
XP_046421491.1	1	Reactome: R-HSA-2299718	"Condensation of Prophase Chromosomes"
XP_046434403.1	3	Reactome: R-HSA-110357;Reactome: R-HSA-110330;Reactome: R-HSA-110331	"Displacement of DNA glycosylase by APEX1";"Recognition and association of DNA glycosylase with site containing an affected purine";"Cleavage of the damaged purine"
XP_046428268.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046431654.1	1	Reactome: R-HSA-435368	"Zinc efflux and compartmentalization by the SLC30 family"
XP_046422727.1	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
XP_046410885.1	3	Reactome: R-HSA-749476;Reactome: R-HSA-76061;Reactome: R-HSA-76066	"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Transcription Initiation From Type 2 Promoter"
XP_046431973.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046433329.1	56	Reactome: R-HSA-5676590;Reactome: R-HSA-5362768;Reactome: R-HSA-9604323;Reactome: R-HSA-69017;Reactome: R-HSA-69601;Reactome: R-HSA-5358346;Reactome: R-HSA-195253;Reactome: R-HSA-174178;Reactome: R-HSA-2871837;Reactome: R-HSA-68949;Reactome: R-HSA-1169091;Reactome: R-HSA-382556;Reactome: R-HSA-4641258;Reactome: R-HSA-211733;Reactome: R-HSA-5632684;Reactome: R-HSA-450408;Reactome: R-HSA-5610780;Reactome: R-HSA-1236974;Reactome: R-HSA-9010553;Reactome: R-HSA-350562;Reactome: R-HSA-8941858;Reactome: R-HSA-5668541;Reactome: R-HSA-180534;Reactome: R-HSA-187577;Reactome: R-HSA-5607764;Reactome: R-HSA-68827;Reactome: R-HSA-5689603;Reactome: R-HSA-5610783;Reactome: R-HSA-8852276;Reactome: R-HSA-69481;Reactome: R-HSA-8948751;Reactome: R-HSA-1234176;Reactome: R-HSA-9020702;Reactome: R-HSA-8854050;Reactome: R-HSA-5687128;Reactome: R-HSA-174113;Reactome: R-HSA-8939902;Reactome: R-HSA-174184;Reactome: R-HSA-174154;Reactome: R-HSA-2467813;Reactome: R-HSA-5658442;Reactome: R-HSA-983168;Reactome: R-HSA-5607761;Reactome: R-HSA-5610785;Reactome: R-HSA-180585;Reactome: R-HSA-5678895;Reactome: R-HSA-8939236;Reactome: R-HSA-349425;Reactome: R-HSA-5689880;Reactome: R-HSA-8951664;Reactome: R-HSA-174084;Reactome: R-HSA-202424;Reactome: R-HSA-75815;Reactome: R-HSA-4608870;Reactome: R-HSA-4641257;Reactome: R-HSA-1236978	"NIK-->noncanonical NF-kB signaling";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Negative regulation of NOTCH4 signaling";"CDK-mediated phosphorylation and removal of Cdc6";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Hedgehog ligand biogenesis";"Degradation of beta-catenin by the destruction complex";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"FCERI mediated NF-kB activation";"Orc1 removal from chromatin";"Activation of NF-kappaB in B cells";"ABC-family proteins mediated transport";"Degradation of DVL";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Hedgehog 'on' state";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Degradation of GLI1 by the proteasome";"ER-Phagosome pathway";"Regulation of expression of SLITs and ROBOs";"Regulation of ornithine decarboxylase (ODC)";"Regulation of RUNX3 expression and activity";"TNFR2 non-canonical NF-kB pathway";"Vpu mediated degradation of CD4";"SCF(Skp2)-mediated degradation of p27/p21";"CLEC7A (Dectin-1) signaling";"CDT1 association with the CDC6:ORC:origin complex";"UCH proteinases";"Degradation of GLI2 by the proteasome";"The role of GTSE1 in G2/M progression after G2 checkpoint";"G2/M Checkpoints";"Regulation of PTEN stability and activity";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Interleukin-1 signaling";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"MAPK6/MAPK4 signaling";"SCF-beta-TrCP mediated degradation of Emi1";"Regulation of RUNX2 expression and activity";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"APC/C:Cdc20 mediated degradation of Securin";"Separation of Sister Chromatids";"Regulation of RAS by GAPs";"Antigen processing: Ubiquitination & Proteasome degradation";"Dectin-1 mediated noncanonical NF-kB signaling";"GLI3 is processed to GLI3R by the proteasome";"Vif-mediated degradation of APOBEC3G";"Defective CFTR causes cystic fibrosis";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Autodegradation of the E3 ubiquitin ligase COP1";"Ub-specific processing proteases";"Neddylation";"Autodegradation of Cdh1 by Cdh1:APC/C";"Downstream TCR signaling";"Ubiquitin-dependent degradation of Cyclin D";"Asymmetric localization of PCP proteins";"Degradation of AXIN";"Cross-presentation of soluble exogenous antigens (endosomes)"
XP_046424770.1	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
XP_046418712.1	3	Reactome: R-HSA-391160;KEGG: 04660+2.7.10.2;Reactome: R-HSA-4420097	"Signal regulatory protein family interactions";"T cell receptor signaling pathway";"VEGFA-VEGFR2 Pathway"
XP_046425778.1	2	MetaCyc: PWY-6854;Reactome: R-HSA-3299685	"Ethylene biosynthesis III (microbes)";"Detoxification of Reactive Oxygen Species"
XP_046419039.1	5	Reactome: R-HSA-2173789;Reactome: R-HSA-8951664;Reactome: R-HSA-917937;Reactome: R-HSA-5689603;Reactome: R-HSA-8856825	"TGF-beta receptor signaling activates SMADs";"Neddylation";"Iron uptake and transport";"UCH proteinases";"Cargo recognition for clathrin-mediated endocytosis"
XP_046427908.1	6	MetaCyc: PWY-7817;MetaCyc: PWY-7039;KEGG: 00561+2.7.1.107;KEGG: 04070+2.7.1.107;Reactome: R-HSA-114508;KEGG: 00564+2.7.1.107	"Type I lipoteichoic acid biosynthesis (S. aureus)";"Phosphatidate metabolism, as a signaling molecule";"Glycerolipid metabolism";"Phosphatidylinositol signaling system";"Effects of PIP2 hydrolysis";"Glycerophospholipid metabolism"
XP_046422514.1	6	Reactome: R-HSA-2500257;Reactome: R-HSA-5663220;Reactome: R-HSA-2467813;Reactome: R-HSA-68877;Reactome: R-HSA-141444;Reactome: R-HSA-9648025	"Resolution of Sister Chromatid Cohesion";"RHO GTPases Activate Formins";"Separation of Sister Chromatids";"Mitotic Prometaphase";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"EML4 and NUDC in mitotic spindle formation"
XP_046422225.1	1	Reactome: R-HSA-6802952	"Signaling by BRAF and RAF fusions"
XP_046436247.1	2	MetaCyc: PWY-6558;Reactome: R-HSA-2022928	"Heparan sulfate biosynthesis (late stages)";"HS-GAG biosynthesis"
XP_046426348.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_046433014.1	7	Reactome: R-HSA-156711;Reactome: R-HSA-1362300;Reactome: R-HSA-69205;Reactome: R-HSA-1362277;Reactome: R-HSA-69202;Reactome: R-HSA-1538133;Reactome: R-HSA-69656	"Polo-like kinase mediated events";"Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1";"G1/S-Specific Transcription";"Transcription of E2F targets under negative control by DREAM complex";"Cyclin E associated events during G1/S transition";"G0 and Early G1";"Cyclin A:Cdk2-associated events at S phase entry"
XP_046420013.1	19	Reactome: R-HSA-9620244;Reactome: R-HSA-5673000;Reactome: R-HSA-6802946;Reactome: R-HSA-5673001;Reactome: R-HSA-6802955;Reactome: R-HSA-6802952;Reactome: R-HSA-9649948;Reactome: R-HSA-3371571;Reactome: R-HSA-442982;Reactome: R-HSA-9617324;Reactome: R-HSA-5576892;Reactome: R-HSA-877300;Reactome: R-HSA-111932;Reactome: R-HSA-9022692;Reactome: R-HSA-438066;Reactome: R-HSA-399719;Reactome: R-HSA-5578775;Reactome: R-HSA-936837;Reactome: R-HSA-9609736	"Long-term potentiation";"RAF activation";"Signaling by moderate kinase activity BRAF mutants";"RAF/MAP kinase cascade";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"Signaling by BRAF and RAF fusions";"Signaling downstream of RAS mutants";"HSF1-dependent transactivation";"Ras activation upon Ca2+ influx through NMDA receptor";"Negative regulation of NMDA receptor-mediated neuronal transmission";"Phase 0 - rapid depolarisation";"Interferon gamma signaling";"CaMK IV-mediated phosphorylation of CREB";"Regulation of MECP2 expression and activity";"Unblocking of NMDA receptors, glutamate binding and activation";"Trafficking of AMPA receptors";"Ion homeostasis";"Ion transport by P-type ATPases";"Assembly and cell surface presentation of NMDA receptors"
XP_046418328.1	7	Reactome: R-HSA-69656;Reactome: R-HSA-1538133;Reactome: R-HSA-69202;Reactome: R-HSA-1362277;Reactome: R-HSA-69205;Reactome: R-HSA-1362300;Reactome: R-HSA-156711	"Cyclin A:Cdk2-associated events at S phase entry";"G0 and Early G1";"Cyclin E associated events during G1/S transition";"Transcription of E2F targets under negative control by DREAM complex";"G1/S-Specific Transcription";"Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1";"Polo-like kinase mediated events"
XP_046411379.1	5	MetaCyc: PWY-7269;KEGG: 00760+2.7.1.23;MetaCyc: PWY-7268;Reactome: R-HSA-196807;MetaCyc: PWY-5083	"NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)";"Nicotinate and nicotinamide metabolism";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"Nicotinate metabolism";"NAD/NADH phosphorylation and dephosphorylation"
XP_046428185.1	3	Reactome: R-HSA-5578775;Reactome: R-HSA-418359;Reactome: R-HSA-425561	"Ion homeostasis";"Reduction of cytosolic Ca++ levels";"Sodium/Calcium exchangers"
XP_046436694.1	12	Reactome: R-HSA-6807878;Reactome: R-HSA-3371497;Reactome: R-HSA-5663220;Reactome: R-HSA-2500257;Reactome: R-HSA-9609690;Reactome: R-HSA-68877;Reactome: R-HSA-9646399;Reactome: R-HSA-2467813;Reactome: R-HSA-6811436;Reactome: R-HSA-9648025;Reactome: R-HSA-141444;Reactome: R-HSA-2132295	"COPI-mediated anterograde transport";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"RHO GTPases Activate Formins";"Resolution of Sister Chromatid Cohesion";"HCMV Early Events";"Mitotic Prometaphase";"Aggrephagy";"Separation of Sister Chromatids";"COPI-independent Golgi-to-ER retrograde traffic";"EML4 and NUDC in mitotic spindle formation";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"MHC class II antigen presentation"
XP_046411334.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_046416089.1	2	Reactome: R-HSA-203927;Reactome: R-HSA-8986944	"MicroRNA (miRNA) biogenesis";"Transcriptional Regulation by MECP2"
XP_046426294.1	2	Reactome: R-HSA-749476;Reactome: R-HSA-73980	"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Termination"
XP_046409532.1	3	Reactome: R-HSA-4420097;Reactome: R-HSA-2029482;Reactome: R-HSA-5663213	"VEGFA-VEGFR2 Pathway";"Regulation of actin dynamics for phagocytic cup formation";"RHO GTPases Activate WASPs and WAVEs"
XP_046410741.1	4	Reactome: R-HSA-112308;Reactome: R-HSA-5576893;Reactome: R-HSA-5576892;Reactome: R-HSA-419037	"Presynaptic depolarization and calcium channel opening";"Phase 2 - plateau phase";"Phase 0 - rapid depolarisation";"NCAM1 interactions"
XP_046423830.1	3	MetaCyc: PWY-7533;Reactome: R-HSA-2142691;Reactome: R-HSA-5423646	"Gliotoxin biosynthesis";"Synthesis of Leukotrienes (LT) and Eoxins (EX)";"Aflatoxin activation and detoxification"
XP_046413432.1	11	Reactome: R-HSA-6785631;Reactome: R-HSA-2219530;Reactome: R-HSA-9664565;Reactome: R-HSA-8847993;Reactome: R-HSA-1257604;Reactome: R-HSA-5673001;Reactome: R-HSA-1227986;Reactome: R-HSA-1250196;Reactome: R-HSA-1963642;Reactome: R-HSA-8863795;Reactome: R-HSA-6811558	"ERBB2 Regulates Cell Motility";"Constitutive Signaling by Aberrant PI3K in Cancer";"Signaling by ERBB2 KD Mutants";"ERBB2 Activates PTK6 Signaling";"PIP3 activates AKT signaling";"RAF/MAP kinase cascade";"Signaling by ERBB2";"SHC1 events in ERBB2 signaling";"PI3K events in ERBB2 signaling";"Downregulation of ERBB2 signaling";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"
XP_046428883.1	20	MetaCyc: PWY-7606;MetaCyc: PWY-7726;MetaCyc: PWY-7854;MetaCyc: PWY-7007;MetaCyc: PWY-7574;MetaCyc: PWY-7337;MetaCyc: PWY-7288;MetaCyc: PWY-7340;KEGG: 00071+1.3.3.6;MetaCyc: PWY-7338;MetaCyc: PWY-7858;MetaCyc: PWY-7291;MetaCyc: PWY-6920;KEGG: 00410+1.3.3.6;Reactome: R-HSA-9033241;MetaCyc: PWY-5136;MetaCyc: PWY-735;KEGG: 00592+1.3.3.6;KEGG: 00640+1.3.3.6;MetaCyc: PWY-6837	"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"Crotonyl-coa/ethylmalonyl-coa/hydroxybutyryl-coa cycle (engineered)";"Methyl ketone biosynthesis (engineered)";"Propanoyl-coa degradation II";"10-cis-heptadecenoyl-CoA degradation (yeast)";"Fatty acid beta-oxidation VII (yeast peroxisome)";"9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast)";"Fatty acid degradation";"10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast)";"(5Z)-dodecenoate biosynthesis II";"Oleate beta-oxidation (isomerase-dependent, yeast)";"6-gingerol analog biosynthesis (engineered)";"beta-Alanine metabolism";"Peroxisomal protein import";"Fatty acid beta-oxidation II (plant peroxisome)";"Jasmonic acid biosynthesis";"alpha-Linolenic acid metabolism";"Propanoate metabolism";"Fatty acid beta-oxidation V (unsaturated, odd number, di-isomerase-dependent)"
XP_046432697.1	1	Reactome: R-HSA-381753	"Olfactory Signaling Pathway"
XP_046414766.1	1	Reactome: R-HSA-8949664	"Processing of SMDT1"
XP_046418749.1	7	KEGG: 00230+2.4.2.7;MetaCyc: PWY-7807;Reactome: R-HSA-74217;MetaCyc: PWY-6610;MetaCyc: PWY-7805;MetaCyc: PWY-6605;Reactome: R-HSA-6798695	"Purine metabolism";"Glyphosate degradation III";"Purine salvage";"Adenine salvage";"(aminomethyl)phosphonate degradation";"Adenine and adenosine salvage II";"Neutrophil degranulation"
XP_046428437.1	7	KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1	"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Relaxin signaling pathway";"Thermogenesis";"Human cytomegalovirus infection"
XP_046412669.1	28	Reactome: R-HSA-174437;Reactome: R-HSA-5358606;Reactome: R-HSA-6782210;Reactome: R-HSA-3371511;Reactome: R-HSA-5685942;Reactome: R-HSA-912446;Reactome: R-HSA-5693607;Reactome: R-HSA-69166;Reactome: R-HSA-5651801;Reactome: R-HSA-6783310;Reactome: R-HSA-110312;Reactome: R-HSA-5685938;Reactome: R-HSA-5696400;Reactome: R-HSA-5358565;Reactome: R-HSA-110320;Reactome: R-HSA-6782135;Reactome: R-HSA-5655862;Reactome: R-HSA-3371453;Reactome: R-HSA-5696397;Reactome: R-HSA-5656121;Reactome: R-HSA-110314;Reactome: R-HSA-68962;Reactome: R-HSA-5696395;Reactome: R-HSA-6804756;Reactome: R-HSA-69473;Reactome: R-HSA-5656169;Reactome: R-HSA-5693616;Reactome: R-HSA-176187	"Removal of the Flap Intermediate from the C-strand";"Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)";"Gap-filling DNA repair synthesis and ligation in TC-NER";"HSF1 activation";"HDR through Homologous Recombination (HRR)";"Meiotic recombination";"Processing of DNA double-strand break ends";"Removal of the Flap Intermediate";"PCNA-Dependent Long Patch Base Excision Repair";"Fanconi Anemia Pathway";"Translesion synthesis by REV1";"HDR through Single Strand Annealing (SSA)";"Dual Incision in GG-NER";"Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)";"Translesion Synthesis by POLH";"Dual incision in TC-NER";"Translesion synthesis by POLK";"Regulation of HSF1-mediated heat shock response";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Translesion synthesis by POLI";"Recognition of DNA damage by PCNA-containing replication complex";"Activation of the pre-replicative complex";"Formation of Incision Complex in GG-NER";"Regulation of TP53 Activity through Phosphorylation";"G2/M DNA damage checkpoint";"Termination of translesion DNA synthesis";"Presynaptic phase of homologous DNA pairing and strand exchange";"Activation of ATR in response to replication stress"
XP_046431198.1	6	Reactome: R-HSA-983712;Reactome: R-HSA-6798695;Reactome: R-HSA-77387;Reactome: R-HSA-1222556;Reactome: R-HSA-917977;Reactome: R-HSA-9639288	"Ion channel transport";"Neutrophil degranulation";"Insulin receptor recycling";"ROS and RNS production in phagocytes";"Transferrin endocytosis and recycling";"Amino acids regulate mTORC1"
XP_046435729.1	1	Reactome: R-HSA-2028269	"Signaling by Hippo"
XP_046436329.1	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
XP_046422871.1	1	Reactome: R-HSA-6794361	"Neurexins and neuroligins"
XP_046434402.1	8	Reactome: R-HSA-5693568;Reactome: R-HSA-5693579;Reactome: R-HSA-5685942;Reactome: R-HSA-912446;Reactome: R-HSA-8953750;Reactome: R-HSA-5685938;Reactome: R-HSA-5693616;Reactome: R-HSA-5693554	"Resolution of D-loop Structures through Holliday Junction Intermediates";"Homologous DNA Pairing and Strand Exchange";"HDR through Homologous Recombination (HRR)";"Meiotic recombination";"Transcriptional Regulation by E2F6";"HDR through Single Strand Annealing (SSA)";"Presynaptic phase of homologous DNA pairing and strand exchange";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)"
XP_046427248.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046421076.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046422570.1	4	Reactome: R-HSA-5693554;Reactome: R-HSA-5685942;Reactome: R-HSA-5693579;Reactome: R-HSA-5693568	"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"HDR through Homologous Recombination (HRR)";"Homologous DNA Pairing and Strand Exchange";"Resolution of D-loop Structures through Holliday Junction Intermediates"
XP_046430772.1	1	Reactome: R-HSA-6809371	"Formation of the cornified envelope"
XP_046415666.1	3	Reactome: R-HSA-1660662;KEGG: 00600+3.1.4.12;MetaCyc: PWY-7277	"Glycosphingolipid metabolism";"Sphingolipid metabolism";"Sphingolipid biosynthesis (mammals)"
XP_046434255.1	3	Reactome: R-HSA-194840;Reactome: R-HSA-416482;Reactome: R-HSA-193648	"Rho GTPase cycle";"G alpha (12/13) signalling events";"NRAGE signals death through JNK"
XP_046411886.1	1	Reactome: R-HSA-425986	"Sodium/Proton exchangers"
XP_046419068.1	1	Reactome: R-HSA-5658442	"Regulation of RAS by GAPs"
XP_046414506.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046418147.1	1	Reactome: R-HSA-1445148	"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
XP_046423151.1	6	Reactome: R-HSA-6804756;Reactome: R-HSA-69473;Reactome: R-HSA-5685938;Reactome: R-HSA-176187;Reactome: R-HSA-5693616;Reactome: R-HSA-5693607	"Regulation of TP53 Activity through Phosphorylation";"G2/M DNA damage checkpoint";"HDR through Single Strand Annealing (SSA)";"Activation of ATR in response to replication stress";"Presynaptic phase of homologous DNA pairing and strand exchange";"Processing of DNA double-strand break ends"
XP_046433911.1	1	Reactome: R-HSA-8876725	"Protein methylation"
XP_046426424.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046416358.1	1	Reactome: R-HSA-5693568	"Resolution of D-loop Structures through Holliday Junction Intermediates"
XP_046414765.1	1	Reactome: R-HSA-8949664	"Processing of SMDT1"
XP_046427705.1	2	Reactome: R-HSA-8939243;Reactome: R-HSA-3214858	"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RMTs methylate histone arginines"
XP_046434841.1	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
XP_046419402.1	2	Reactome: R-HSA-379726;KEGG: 00970+6.1.1.15	"Mitochondrial tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis"
XP_046426498.1	7	KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1	"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Relaxin signaling pathway";"Thermogenesis";"Human cytomegalovirus infection";"mTOR signaling pathway";"PI3K-Akt signaling pathway"
XP_046417542.1	2	Reactome: R-HSA-936837;Reactome: R-HSA-6798695	"Ion transport by P-type ATPases";"Neutrophil degranulation"
XP_046428353.1	1	Reactome: R-HSA-5389840	"Mitochondrial translation elongation"
XP_046435512.1	5	Reactome: R-HSA-9627069;KEGG: 00270+4.2.1.109;Reactome: R-HSA-1237112;MetaCyc: PWY-4361;Reactome: R-HSA-111458	"Regulation of the apoptosome activity";"Cysteine and methionine metabolism";"Methionine salvage pathway";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I";"Formation of apoptosome"
XP_046418309.1	2	Reactome: R-HSA-446203;Reactome: R-HSA-1799339	"Asparagine N-linked glycosylation";"SRP-dependent cotranslational protein targeting to membrane"
XP_046428836.1	1	Reactome: R-HSA-191859	"snRNP Assembly"
XP_046414471.1	2	KEGG: 00073+2.3.1.20;KEGG: 00561+2.3.1.20	"Cutin, suberine and wax biosynthesis";"Glycerolipid metabolism"
XP_046433657.1	6	Reactome: R-HSA-1855183;Reactome: R-HSA-194840;KEGG: 04070+3.1.3.36;Reactome: R-HSA-1855204;MetaCyc: PWY-6368;KEGG: 00562+3.1.3.36	"Synthesis of IP2, IP, and Ins in the cytosol";"Rho GTPase cycle";"Phosphatidylinositol signaling system";"Synthesis of IP3 and IP4 in the cytosol";"3-phosphoinositide degradation";"Inositol phosphate metabolism"
XP_046409321.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_046432082.1	7	KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1	"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Relaxin signaling pathway";"Thermogenesis";"Human cytomegalovirus infection";"mTOR signaling pathway";"PI3K-Akt signaling pathway"
XP_046435846.1	3	MetaCyc: PWY-5686;Reactome: R-HSA-500753;KEGG: 00240+1.3.5.2	"UMP biosynthesis I";"Pyrimidine biosynthesis";"Pyrimidine metabolism"
XP_046413236.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_046436562.1	9	Reactome: R-HSA-3304356;Reactome: R-HSA-3656535;Reactome: R-HSA-3645790;Reactome: R-HSA-2173788;Reactome: R-HSA-3642279;Reactome: R-HSA-5689603;Reactome: R-HSA-2173789;Reactome: R-HSA-2173791;Reactome: R-HSA-3656532	"SMAD2/3 Phosphorylation Motif Mutants in Cancer";"TGFBR1 LBD Mutants in Cancer";"TGFBR2 Kinase Domain Mutants in Cancer";"Downregulation of TGF-beta receptor signaling";"TGFBR2 MSI Frameshift Mutants in Cancer";"UCH proteinases";"TGF-beta receptor signaling activates SMADs";"TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)";"TGFBR1 KD Mutants in Cancer"
XP_046426099.1	2	KEGG: 00270+3.3.1.1;MetaCyc: PWY-5041	"Cysteine and methionine metabolism";"S-adenosyl-L-methionine cycle II"
XP_046425143.1	1	Reactome: R-HSA-1221632	"Meiotic synapsis"
XP_046420007.1	19	Reactome: R-HSA-5673001;Reactome: R-HSA-9620244;Reactome: R-HSA-5673000;Reactome: R-HSA-6802946;Reactome: R-HSA-442982;Reactome: R-HSA-6802952;Reactome: R-HSA-9649948;Reactome: R-HSA-3371571;Reactome: R-HSA-6802955;Reactome: R-HSA-9022692;Reactome: R-HSA-111932;Reactome: R-HSA-438066;Reactome: R-HSA-9617324;Reactome: R-HSA-5576892;Reactome: R-HSA-877300;Reactome: R-HSA-9609736;Reactome: R-HSA-936837;Reactome: R-HSA-5578775;Reactome: R-HSA-399719	"RAF/MAP kinase cascade";"Long-term potentiation";"RAF activation";"Signaling by moderate kinase activity BRAF mutants";"Ras activation upon Ca2+ influx through NMDA receptor";"Signaling by BRAF and RAF fusions";"Signaling downstream of RAS mutants";"HSF1-dependent transactivation";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"Regulation of MECP2 expression and activity";"CaMK IV-mediated phosphorylation of CREB";"Unblocking of NMDA receptors, glutamate binding and activation";"Negative regulation of NMDA receptor-mediated neuronal transmission";"Phase 0 - rapid depolarisation";"Interferon gamma signaling";"Assembly and cell surface presentation of NMDA receptors";"Ion transport by P-type ATPases";"Ion homeostasis";"Trafficking of AMPA receptors"
XP_046413548.1	7	MetaCyc: PWY-7511;Reactome: R-HSA-2691232;Reactome: R-HSA-2979096;Reactome: R-HSA-9013507;Reactome: R-HSA-2644606;Reactome: R-HSA-2894862;Reactome: R-HSA-2122948	"Protein ubiquitination";"Constitutive Signaling by NOTCH1 HD Domain Mutants";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Activated NOTCH1 Transmits Signal to the Nucleus"
XP_046419658.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046420693.1	4	KEGG: 00010+3.1.3.9;Reactome: R-HSA-70263;KEGG: 00052+3.1.3.9;KEGG: 00500+3.1.3.9	"Glycolysis / Gluconeogenesis";"Gluconeogenesis";"Galactose metabolism";"Starch and sucrose metabolism"
XP_046417816.1	5	Reactome: R-HSA-5221030;Reactome: R-HSA-110329;Reactome: R-HSA-110328;Reactome: R-HSA-110357;Reactome: R-HSA-3108214	"TET1,2,3 and TDG demethylate DNA";"Cleavage of the damaged pyrimidine";"Recognition and association of DNA glycosylase with site containing an affected pyrimidine";"Displacement of DNA glycosylase by APEX1";"SUMOylation of DNA damage response and repair proteins"
XP_046436306.1	4	Reactome: R-HSA-6798163;KEGG: 00260+1.2.1.8+1.1.99.1;MetaCyc: PWY-3722;MetaCyc: PWY-7494	"Choline catabolism";"Glycine, serine and threonine metabolism";"Glycine betaine biosynthesis II (Gram-positive bacteria)";"Choline degradation IV"
XP_046420639.1	2	Reactome: R-HSA-379726;KEGG: 00970+6.1.1.5	"Mitochondrial tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis"
XP_046424563.1	1	Reactome: R-HSA-6784531	"tRNA processing in the nucleus"
XP_046427499.1	1	Reactome: R-HSA-3371453	"Regulation of HSF1-mediated heat shock response"
XP_046412069.1	1	Reactome: R-HSA-977347	"Serine biosynthesis"
XP_046412984.1	1	Reactome: R-HSA-112126	"ALKBH3 mediated reversal of alkylation damage"
XP_046431017.1	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
XP_046411582.1	7	Reactome: R-HSA-76066;Reactome: R-HSA-76061;Reactome: R-HSA-76071;Reactome: R-HSA-1834949;Reactome: R-HSA-749476;Reactome: R-HSA-73980;Reactome: R-HSA-73780	"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Termination";"RNA Polymerase III Chain Elongation"
XP_046412709.1	1	Reactome: R-HSA-1799339	"SRP-dependent cotranslational protein targeting to membrane"
XP_046419850.1	3	KEGG: 00740+3.1.3.2;MetaCyc: PWY-6348;KEGG: 00730+3.1.3.2	"Riboflavin metabolism";"Phosphate acquisition";"Thiamine metabolism"
XP_046409980.1	2	Reactome: R-HSA-3214858;Reactome: R-HSA-8939243	"RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"
XP_046427182.1	11	KEGG: 04926+2.7.11.1;Reactome: R-HSA-4420097;Reactome: R-HSA-171007;KEGG: 05163+2.7.11.1;Reactome: R-HSA-450302;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;Reactome: R-HSA-2559580	"Relaxin signaling pathway";"VEGFA-VEGFR2 Pathway";"p38MAPK events";"Human cytomegalovirus infection";"activated TAK1 mediates p38 MAPK activation";"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Thermogenesis";"Oxidative Stress Induced Senescence"
XP_046432588.1	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
XP_046423032.1	2	Reactome: R-HSA-425366;Reactome: R-HSA-1483191	"Transport of bile salts and organic acids, metal ions and amine compounds";"Synthesis of PC"
XP_046432829.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_046432454.1	6	KEGG: 00750+2.6.1.52;KEGG: 00260+2.6.1.52;MetaCyc: PWY-8010;KEGG: 00270+2.6.1.52;KEGG: 00680+2.6.1.52;Reactome: R-HSA-977347	"Vitamin B6 metabolism";"Glycine, serine and threonine metabolism";"L-cysteine biosynthesis IX (Trichomonas vaginalis)";"Cysteine and methionine metabolism";"Methane metabolism";"Serine biosynthesis"
XP_046421262.1	1	Reactome: R-HSA-1221632	"Meiotic synapsis"
XP_046412515.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_046412314.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_046428186.1	3	Reactome: R-HSA-425561;Reactome: R-HSA-418359;Reactome: R-HSA-5578775	"Sodium/Calcium exchangers";"Reduction of cytosolic Ca++ levels";"Ion homeostasis"
XP_046419765.1	1	Reactome: R-HSA-420499	"Class C/3 (Metabotropic glutamate/pheromone receptors)"
XP_046424647.1	1	Reactome: R-HSA-6787450	"tRNA modification in the mitochondrion"
XP_046432710.1	2	Reactome: R-HSA-69273;Reactome: R-HSA-8862803	"Cyclin A/B1/B2 associated events during G2/M transition";"Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models"
XP_046426568.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046427323.1	2	Reactome: R-HSA-8856825;Reactome: R-HSA-8856828	"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis"
XP_046429762.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_046411390.1	4	Reactome: R-HSA-6782315;Reactome: R-HSA-6787450;MetaCyc: PWY-2781;KEGG: 00908+2.5.1.75	"tRNA modification in the nucleus and cytosol";"tRNA modification in the mitochondrion";"Cis-zeatin biosynthesis";"Zeatin biosynthesis"
XP_046419513.1	3	Reactome: R-HSA-3000157;Reactome: R-HSA-8874081;Reactome: R-HSA-3000171	"Laminin interactions";"MET activates PTK2 signaling";"Non-integrin membrane-ECM interactions"
XP_046412454.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_046423773.1	14	Reactome: R-HSA-3928665;Reactome: R-HSA-205043;Reactome: R-HSA-6798695;Reactome: R-HSA-1474228;Reactome: R-HSA-2644606;Reactome: R-HSA-2979096;Reactome: R-HSA-2122948;Reactome: R-HSA-977225;Reactome: R-HSA-2894862;Reactome: R-HSA-9013700;Reactome: R-HSA-1251985;Reactome: R-HSA-9013507;Reactome: R-HSA-9017802;Reactome: R-HSA-193692	"EPH-ephrin mediated repulsion of cells";"NRIF signals cell death from the nucleus";"Neutrophil degranulation";"Degradation of the extracellular matrix";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Activated NOTCH1 Transmits Signal to the Nucleus";"Amyloid fiber formation";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"NOTCH4 Activation and Transmission of Signal to the Nucleus";"Nuclear signaling by ERBB4";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Noncanonical activation of NOTCH3";"Regulated proteolysis of p75NTR"
XP_046416849.1	6	KEGG: 00073+1.2.1.84;MetaCyc: PWY-7656;MetaCyc: PWY-6733;Reactome: R-HSA-9640463;MetaCyc: PWY-5884;MetaCyc: PWY-7782	"Cutin, suberine and wax biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Sporopollenin precursors biosynthesis";"Wax biosynthesis";"Wax esters biosynthesis I";"Plasmalogen biosynthesis"
XP_046429265.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046425850.1	1	Reactome: R-HSA-71064	"Lysine catabolism"
XP_046429432.1	1	Reactome: R-HSA-5625900	"RHO GTPases activate CIT"
XP_046431997.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_046436700.1	3	MetaCyc: PWY-7894;KEGG: 00330+1.14.11.2;Reactome: R-HSA-1650814	"Procollagen hydroxylation and glycosylation";"Arginine and proline metabolism";"Collagen biosynthesis and modifying enzymes"
XP_046420875.1	7	MetaCyc: PWY-6840;MetaCyc: PWY-8043;Reactome: R-HSA-5578999;Reactome: R-HSA-174403;MetaCyc: PWY-7255;KEGG: 00480+6.3.2.2;KEGG: 00270+6.3.2.2	"Homoglutathione biosynthesis";"Ophthalmate biosynthesis";"Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD)";"Glutathione synthesis and recycling";"Ergothioneine biosynthesis I (bacteria)";"Glutathione metabolism";"Cysteine and methionine metabolism"
XP_046432033.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_046412605.1	1	Reactome: R-HSA-176974	"Unwinding of DNA"
XP_046410168.1	1	Reactome: R-HSA-77289	"Mitochondrial Fatty Acid Beta-Oxidation"
XP_046425681.1	4	Reactome: R-HSA-8856825;Reactome: R-HSA-5696394;Reactome: R-HSA-6781823;Reactome: R-HSA-8951664	"Cargo recognition for clathrin-mediated endocytosis";"DNA Damage Recognition in GG-NER";"Formation of TC-NER Pre-Incision Complex";"Neddylation"
XP_046435088.1	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6790901	"Major pathway of rRNA processing in the nucleolus and cytosol";"rRNA modification in the nucleus and cytosol"
XP_046434046.1	1	Reactome: R-HSA-8953750	"Transcriptional Regulation by E2F6"
XP_046434888.1	12	MetaCyc: PWY-5108;KEGG: 00010+6.2.1.1;KEGG: 00630+6.2.1.1;MetaCyc: PWY-5132;KEGG: 00620+6.2.1.1;KEGG: 00640+6.2.1.1;MetaCyc: PWY-7118;KEGG: 00720+6.2.1.1;MetaCyc: PWY-6672;MetaCyc: PWY-7857;MetaCyc: PWY-5133;KEGG: 00680+6.2.1.1	"L-isoleucine biosynthesis V";"Glycolysis / Gluconeogenesis";"Glyoxylate and dicarboxylate metabolism";"Lupulone and humulone biosynthesis";"Pyruvate metabolism";"Propanoate metabolism";"Chitin degradation to ethanol";"Carbon fixation pathways in prokaryotes";"Cis-genanyl-coa degradation";"Adlupulone and adhumulone biosynthesis";"Colupulone and cohumulone biosynthesis";"Methane metabolism"
XP_046427965.1	2	Reactome: R-HSA-2151201;Reactome: R-HSA-1989781	"Transcriptional activation of mitochondrial biogenesis";"PPARA activates gene expression"
XP_046431651.1	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
XP_046416788.1	5	MetaCyc: PWY-6558;KEGG: 00534+2.4.1.224+2.4.1.225;Reactome: R-HSA-2022928;Reactome: R-HSA-3656237;Reactome: R-HSA-3656253	"Heparan sulfate biosynthesis (late stages)";"Glycosaminoglycan biosynthesis - heparan sulfate / heparin";"HS-GAG biosynthesis";"Defective EXT2 causes exostoses 2";"Defective EXT1 causes exostoses 1, TRPS2 and CHDS"
XP_046435880.1	3	Reactome: R-HSA-8963901;Reactome: R-HSA-6807878;Reactome: R-HSA-445095	"Chylomicron remodeling";"COPI-mediated anterograde transport";"Interaction between L1 and Ankyrins"
XP_046426740.1	8	Reactome: R-HSA-165159;Reactome: R-HSA-380972;Reactome: R-HSA-166208;Reactome: R-HSA-1632852;Reactome: R-HSA-9639288;Reactome: R-HSA-8943724;Reactome: R-HSA-5628897;Reactome: R-HSA-3371571	"mTOR signalling";"Energy dependent regulation of mTOR by LKB1-AMPK";"mTORC1-mediated signalling";"Macroautophagy";"Amino acids regulate mTORC1";"Regulation of PTEN gene transcription";"TP53 Regulates Metabolic Genes";"HSF1-dependent transactivation"
XP_046410968.1	3	Reactome: R-HSA-73856;Reactome: R-HSA-159236;Reactome: R-HSA-72187	"RNA Polymerase II Transcription Termination";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"mRNA 3'-end processing"
XP_046420335.1	18	Reactome: R-HSA-1482801;MetaCyc: PWY-7417;KEGG: 00565+3.1.1.4;Reactome: R-HSA-1482788;MetaCyc: PWY-8051;Reactome: R-HSA-1482922;KEGG: 00592+3.1.1.4;Reactome: R-HSA-1483166;KEGG: 00590+3.1.1.4;Reactome: R-HSA-1482839;MetaCyc: PWY-7416;MetaCyc: PWY-8053;MetaCyc: PWY-7409;KEGG: 00564+3.1.1.4;KEGG: 00591+3.1.1.4;MetaCyc: PWY-6803;Reactome: R-HSA-1482925;MetaCyc: PWY-7783	"Acyl chain remodelling of PS";"Phospholipid remodeling (phosphatidate, yeast)";"Ether lipid metabolism";"Acyl chain remodelling of PC";"Anandamide biosynthesis I";"Acyl chain remodelling of PI";"alpha-Linolenic acid metabolism";"Synthesis of PA";"Arachidonic acid metabolism";"Acyl chain remodelling of PE";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Anandamide biosynthesis II";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Glycerophospholipid metabolism";"Linoleic acid metabolism";"Phosphatidylcholine acyl editing";"Acyl chain remodelling of PG";"Plasmalogen degradation"
XP_046417780.1	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276	"Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination"
XP_046410224.1	6	Reactome: R-HSA-111367;Reactome: R-HSA-72165;Reactome: R-HSA-73856;Reactome: R-HSA-77588;Reactome: R-HSA-191859;Reactome: R-HSA-72163	"SLBP independent Processing of Histone Pre-mRNAs";"mRNA Splicing - Minor Pathway";"RNA Polymerase II Transcription Termination";"SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs";"snRNP Assembly";"mRNA Splicing - Major Pathway"
XP_046411100.1	2	Reactome: R-HSA-6784531;Reactome: R-HSA-6791226	"tRNA processing in the nucleus";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046428865.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_046428691.1	1	KEGG: 00760+2.3.1.286	"Nicotinate and nicotinamide metabolism"
XP_046435160.1	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
XP_046433554.1	1	Reactome: R-HSA-6790901	"rRNA modification in the nucleus and cytosol"
XP_046428731.1	13	Reactome: R-HSA-72764;Reactome: R-HSA-975956;Reactome: R-HSA-156902;Reactome: R-HSA-6791226;Reactome: R-HSA-975957;Reactome: R-HSA-1799339;Reactome: R-HSA-2408557;Reactome: R-HSA-72706;Reactome: R-HSA-192823;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-9633012;Reactome: R-HSA-72689	"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Peptide chain elongation";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"SRP-dependent cotranslational protein targeting to membrane";"Selenocysteine synthesis";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Viral mRNA Translation";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Formation of a pool of free 40S subunits"
XP_046410129.1	6	KEGG: 00562+3.1.3.66;MetaCyc: PWY-6368;KEGG: 04070+3.1.3.66;Reactome: R-HSA-1660499;Reactome: R-HSA-1660516;Reactome: R-HSA-1855183	"Inositol phosphate metabolism";"3-phosphoinositide degradation";"Phosphatidylinositol signaling system";"Synthesis of PIPs at the plasma membrane";"Synthesis of PIPs at the early endosome membrane";"Synthesis of IP2, IP, and Ins in the cytosol"
XP_046419417.1	1	Reactome: R-HSA-432722	"Golgi Associated Vesicle Biogenesis"
XP_046433452.1	2	Reactome: R-HSA-8866423;Reactome: R-HSA-8963888	"VLDL assembly";"Chylomicron assembly"
XP_046421986.1	2	Reactome: R-HSA-418457;Reactome: R-HSA-1296052	"cGMP effects";"Ca2+ activated K+ channels"
XP_046417236.1	7	Reactome: R-HSA-5663220;Reactome: R-HSA-2500257;Reactome: R-HSA-9648025;Reactome: R-HSA-141444;Reactome: R-HSA-68877;Reactome: R-HSA-4615885;Reactome: R-HSA-2467813	"RHO GTPases Activate Formins";"Resolution of Sister Chromatid Cohesion";"EML4 and NUDC in mitotic spindle formation";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Mitotic Prometaphase";"SUMOylation of DNA replication proteins";"Separation of Sister Chromatids"
XP_046432441.1	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
XP_046419159.1	9	Reactome: R-HSA-6802946;Reactome: R-HSA-6798695;Reactome: R-HSA-445355;Reactome: R-HSA-6802955;Reactome: R-HSA-114608;Reactome: R-HSA-5674135;Reactome: R-HSA-6802948;Reactome: R-HSA-6802952;Reactome: R-HSA-9649948	"Signaling by moderate kinase activity BRAF mutants";"Neutrophil degranulation";"Smooth Muscle Contraction";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"Platelet degranulation";"MAP2K and MAPK activation";"Signaling by high-kinase activity BRAF mutants";"Signaling by BRAF and RAF fusions";"Signaling downstream of RAS mutants"
XP_046435281.1	29	MetaCyc: PWY-5751;MetaCyc: PWY-6333;KEGG: 00830+1.1.1.1;KEGG: 00982+1.1.1.1;MetaCyc: PWY-7396;MetaCyc: PWY-6802;KEGG: 00626+1.1.1.1;KEGG: 00010+1.1.1.1;MetaCyc: PWY-5079;KEGG: 00350+1.1.1.1;MetaCyc: PWY-7111;MetaCyc: PWY-5078;MetaCyc: PWY-5076;MetaCyc: PWY-6342;KEGG: 00071+1.1.1.1;MetaCyc: PWY-3162;MetaCyc: PWY-5480;MetaCyc: PWY-7013;MetaCyc: PWY-6871;MetaCyc: PWY-5486;MetaCyc: PWY-6313;MetaCyc: PWY-6587;KEGG: 00260+1.1.1.1;KEGG: 00592+1.1.1.1;KEGG: 00625+1.1.1.1;KEGG: 00980+1.1.1.1;MetaCyc: PWY-7118;MetaCyc: PWY-5057;MetaCyc: PWY-5082	"Phenylethanol biosynthesis";"Acetaldehyde biosynthesis I";"Retinol metabolism";"Drug metabolism - cytochrome P450";"Butanol and isobutanol biosynthesis (engineered)";"Salidroside biosynthesis";"Naphthalene degradation";"Glycolysis / Gluconeogenesis";"L-phenylalanine degradation III";"Tyrosine metabolism";"Pyruvate fermentation to isobutanol (engineered)";"L-isoleucine degradation II";"L-leucine degradation III";"Noradrenaline and adrenaline degradation";"Fatty acid degradation";"L-tryptophan degradation V (side chain pathway)";"Pyruvate fermentation to ethanol I";"(S)-propane-1,2-diol degradation";"3-methylbutanol biosynthesis (engineered)";"Pyruvate fermentation to ethanol II";"Serotonin degradation";"Pyruvate fermentation to ethanol III";"Glycine, serine and threonine metabolism";"alpha-Linolenic acid metabolism";"Chloroalkane and chloroalkene degradation";"Metabolism of xenobiotics by cytochrome P450";"Chitin degradation to ethanol";"L-valine degradation II";"L-methionine degradation III"
XP_046424895.1	14	Reactome: R-HSA-8854518;Reactome: R-HSA-380270;Reactome: R-HSA-2500257;Reactome: R-HSA-5663220;Reactome: R-HSA-5620912;Reactome: R-HSA-2467813;Reactome: R-HSA-6811436;Reactome: R-HSA-68877;Reactome: R-HSA-380259;Reactome: R-HSA-380320;Reactome: R-HSA-141444;Reactome: R-HSA-2565942;Reactome: R-HSA-9648025;Reactome: R-HSA-380284	"AURKA Activation by TPX2";"Recruitment of mitotic centrosome proteins and complexes";"Resolution of Sister Chromatid Cohesion";"RHO GTPases Activate Formins";"Anchoring of the basal body to the plasma membrane";"Separation of Sister Chromatids";"COPI-independent Golgi-to-ER retrograde traffic";"Mitotic Prometaphase";"Loss of Nlp from mitotic centrosomes";"Recruitment of NuMA to mitotic centrosomes";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Regulation of PLK1 Activity at G2/M Transition";"EML4 and NUDC in mitotic spindle formation";"Loss of proteins required for interphase microtubule organization from the centrosome"
XP_046423261.1	17	MetaCyc: PWY-5744;MetaCyc: PWY-6722;KEGG: 00254+6.4.1.2;KEGG: 00620+6.4.1.2;Reactome: R-HSA-163765;MetaCyc: PWY-5743;Reactome: R-HSA-2426168;KEGG: 00720+6.4.1.2;MetaCyc: PWY-6679;MetaCyc: PWY-5966-1;KEGG: 00640+6.4.1.2;Reactome: R-HSA-200425;Reactome: R-HSA-196780;MetaCyc: PWY-4381;Reactome: R-HSA-3371599;KEGG: 00061+6.4.1.2;MetaCyc: PWY-5789	"Glyoxylate assimilation";"Candicidin biosynthesis";"Aflatoxin biosynthesis";"Pyruvate metabolism";"ChREBP activates metabolic gene expression";"3-hydroxypropanoate cycle";"Activation of gene expression by SREBF (SREBP)";"Carbon fixation pathways in prokaryotes";"Jadomycin biosynthesis";"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)";"Propanoate metabolism";"Carnitine metabolism";"Biotin transport and metabolism";"Fatty acid biosynthesis initiation (bacteria and plants)";"Defective HLCS causes multiple carboxylase deficiency";"Fatty acid biosynthesis";"3-hydroxypropanoate/4-hydroxybutanate cycle"
XP_046434581.1	3	Reactome: R-HSA-418597;KEGG: 04070+2.7.11.13;Reactome: R-HSA-114508	"G alpha (z) signalling events";"Phosphatidylinositol signaling system";"Effects of PIP2 hydrolysis"
XP_046415629.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046423484.1	3	Reactome: R-HSA-5617472;Reactome: R-HSA-6804115;Reactome: R-HSA-429947	"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Deadenylation of mRNA"
XP_046420043.1	3	MetaCyc: PWY-7511;Reactome: R-HSA-110314;Reactome: R-HSA-8866654	"Protein ubiquitination";"Recognition of DNA damage by PCNA-containing replication complex";"E3 ubiquitin ligases ubiquitinate target proteins"
XP_046414307.1	56	Reactome: R-HSA-8939902;Reactome: R-HSA-174184;Reactome: R-HSA-174154;Reactome: R-HSA-2467813;Reactome: R-HSA-5658442;Reactome: R-HSA-983168;Reactome: R-HSA-5607761;Reactome: R-HSA-5610785;Reactome: R-HSA-5678895;Reactome: R-HSA-180585;Reactome: R-HSA-8939236;Reactome: R-HSA-349425;Reactome: R-HSA-8951664;Reactome: R-HSA-5689880;Reactome: R-HSA-174084;Reactome: R-HSA-202424;Reactome: R-HSA-75815;Reactome: R-HSA-4641257;Reactome: R-HSA-4608870;Reactome: R-HSA-1236978;Reactome: R-HSA-5362768;Reactome: R-HSA-5676590;Reactome: R-HSA-9604323;Reactome: R-HSA-69017;Reactome: R-HSA-5358346;Reactome: R-HSA-69601;Reactome: R-HSA-195253;Reactome: R-HSA-2871837;Reactome: R-HSA-174178;Reactome: R-HSA-382556;Reactome: R-HSA-68949;Reactome: R-HSA-1169091;Reactome: R-HSA-211733;Reactome: R-HSA-4641258;Reactome: R-HSA-5632684;Reactome: R-HSA-5610780;Reactome: R-HSA-450408;Reactome: R-HSA-1236974;Reactome: R-HSA-8941858;Reactome: R-HSA-9010553;Reactome: R-HSA-350562;Reactome: R-HSA-5668541;Reactome: R-HSA-187577;Reactome: R-HSA-180534;Reactome: R-HSA-5607764;Reactome: R-HSA-68827;Reactome: R-HSA-5689603;Reactome: R-HSA-5610783;Reactome: R-HSA-8852276;Reactome: R-HSA-69481;Reactome: R-HSA-8948751;Reactome: R-HSA-1234176;Reactome: R-HSA-8854050;Reactome: R-HSA-9020702;Reactome: R-HSA-5687128;Reactome: R-HSA-174113	"Regulation of RUNX2 expression and activity";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"APC/C:Cdc20 mediated degradation of Securin";"Separation of Sister Chromatids";"Regulation of RAS by GAPs";"Antigen processing: Ubiquitination & Proteasome degradation";"Dectin-1 mediated noncanonical NF-kB signaling";"GLI3 is processed to GLI3R by the proteasome";"Defective CFTR causes cystic fibrosis";"Vif-mediated degradation of APOBEC3G";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Autodegradation of the E3 ubiquitin ligase COP1";"Neddylation";"Ub-specific processing proteases";"Autodegradation of Cdh1 by Cdh1:APC/C";"Downstream TCR signaling";"Ubiquitin-dependent degradation of Cyclin D";"Degradation of AXIN";"Asymmetric localization of PCP proteins";"Cross-presentation of soluble exogenous antigens (endosomes)";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"NIK-->noncanonical NF-kB signaling";"Negative regulation of NOTCH4 signaling";"CDK-mediated phosphorylation and removal of Cdc6";"Hedgehog ligand biogenesis";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Degradation of beta-catenin by the destruction complex";"FCERI mediated NF-kB activation";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"ABC-family proteins mediated transport";"Orc1 removal from chromatin";"Activation of NF-kappaB in B cells";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Degradation of DVL";"Hedgehog 'on' state";"Degradation of GLI1 by the proteasome";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"ER-Phagosome pathway";"Regulation of RUNX3 expression and activity";"Regulation of expression of SLITs and ROBOs";"Regulation of ornithine decarboxylase (ODC)";"TNFR2 non-canonical NF-kB pathway";"SCF(Skp2)-mediated degradation of p27/p21";"Vpu mediated degradation of CD4";"CLEC7A (Dectin-1) signaling";"CDT1 association with the CDC6:ORC:origin complex";"UCH proteinases";"Degradation of GLI2 by the proteasome";"The role of GTSE1 in G2/M progression after G2 checkpoint";"G2/M Checkpoints";"Regulation of PTEN stability and activity";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Interleukin-1 signaling";"MAPK6/MAPK4 signaling";"SCF-beta-TrCP mediated degradation of Emi1"
XP_046409414.1	2	Reactome: R-HSA-375276;Reactome: R-HSA-416476	"Peptide ligand-binding receptors";"G alpha (q) signalling events"
XP_046427531.1	1	Reactome: R-HSA-1632852	"Macroautophagy"
XP_046418999.1	2	KEGG: 04660+2.7.10.2;Reactome: R-HSA-1433557	"T cell receptor signaling pathway";"Signaling by SCF-KIT"
XP_046416145.1	10	KEGG: 00561+2.3.1.15;KEGG: 00564+2.3.1.15;MetaCyc: PWY-5667;MetaCyc: PWY-8055;MetaCyc: PWY-6453;MetaCyc: PWY-8051;MetaCyc: PWY-7587;MetaCyc: PWY-7411;Reactome: R-HSA-1483166;MetaCyc: PWY-8053	"Glycerolipid metabolism";"Glycerophospholipid metabolism";"CDP-diacylglycerol biosynthesis I";"Palmitoyl ethanolamide biosynthesis";"Stigma estolide biosynthesis";"Anandamide biosynthesis I";"Oleate biosynthesis III (cyanobacteria)";"Phosphatidate biosynthesis (yeast)";"Synthesis of PA";"Anandamide biosynthesis II"
XP_046424927.1	1	Reactome: R-HSA-432720	"Lysosome Vesicle Biogenesis"
XP_046436295.1	7	Reactome: R-HSA-380284;Reactome: R-HSA-5620912;Reactome: R-HSA-380320;Reactome: R-HSA-2565942;Reactome: R-HSA-380270;Reactome: R-HSA-8854518;Reactome: R-HSA-380259	"Loss of proteins required for interphase microtubule organization from the centrosome";"Anchoring of the basal body to the plasma membrane";"Recruitment of NuMA to mitotic centrosomes";"Regulation of PLK1 Activity at G2/M Transition";"Recruitment of mitotic centrosome proteins and complexes";"AURKA Activation by TPX2";"Loss of Nlp from mitotic centrosomes"
XP_046434634.1	8	KEGG: 05163+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;Reactome: R-HSA-437239	"Human cytomegalovirus infection";"Relaxin signaling pathway";"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Thermogenesis";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Recycling pathway of L1"
XP_046414356.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046435583.1	6	Reactome: R-HSA-70370;MetaCyc: PWY-6317;KEGG: 00052+2.7.7.12;Reactome: R-HSA-5609978;MetaCyc: PWY-6527;KEGG: 00520+2.7.7.12	"Galactose catabolism";"D-galactose degradation I (Leloir pathway)";"Galactose metabolism";"Defective GALT can cause Galactosemia";"Stachyose degradation";"Amino sugar and nucleotide sugar metabolism"
XP_046416555.1	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
XP_046427530.1	1	Reactome: R-HSA-1971475	"A tetrasaccharide linker sequence is required for GAG synthesis"
XP_046434408.1	1	Reactome: R-HSA-8851805	"MET activates RAS signaling"
XP_046428262.1	1	Reactome: R-HSA-83936	"Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"
XP_046425173.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_046413034.1	4	Reactome: R-HSA-73817;KEGG: 00230+6.3.5.2;MetaCyc: PWY-7221;KEGG: 00983+6.3.5.2	"Purine ribonucleoside monophosphate biosynthesis";"Purine metabolism";"Guanosine ribonucleotides de novo biosynthesis";"Drug metabolism - other enzymes"
XP_046413564.1	1	Reactome: R-HSA-420499	"Class C/3 (Metabotropic glutamate/pheromone receptors)"
XP_046433846.1	1	Reactome: R-HSA-1474228	"Degradation of the extracellular matrix"
XP_046418268.1	7	Reactome: R-HSA-141444;Reactome: R-HSA-5626467;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813;Reactome: R-HSA-68877;Reactome: R-HSA-2500257;Reactome: R-HSA-5663220	"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"RHO GTPases activate IQGAPs";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids";"Mitotic Prometaphase";"Resolution of Sister Chromatid Cohesion";"RHO GTPases Activate Formins"
XP_046417349.1	8	Reactome: R-HSA-6804756;Reactome: R-HSA-5628897;Reactome: R-HSA-9613354;Reactome: R-HSA-1632852;Reactome: R-HSA-9619483;Reactome: R-HSA-2151209;Reactome: R-HSA-380972;Reactome: R-HSA-1445148	"Regulation of TP53 Activity through Phosphorylation";"TP53 Regulates Metabolic Genes";"Lipophagy";"Macroautophagy";"Activation of AMPK downstream of NMDARs";"Activation of PPARGC1A (PGC-1alpha) by phosphorylation";"Energy dependent regulation of mTOR by LKB1-AMPK";"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
XP_046428475.1	3	Reactome: R-HSA-6798695;Reactome: R-HSA-2024096;Reactome: R-HSA-2206291	"Neutrophil degranulation";"HS-GAG degradation";"MPS IIIC - Sanfilippo syndrome C"
XP_046413892.1	6	Reactome: R-HSA-68949;Reactome: R-HSA-68962;Reactome: R-HSA-69052;Reactome: R-HSA-176187;Reactome: R-HSA-68867;Reactome: R-HSA-176974	"Orc1 removal from chromatin";"Activation of the pre-replicative complex";"Switching of origins to a post-replicative state";"Activation of ATR in response to replication stress";"Assembly of the pre-replicative complex";"Unwinding of DNA"
XP_046424329.1	14	MetaCyc: PWY-5972;Reactome: R-HSA-75876;MetaCyc: PWY-7724;MetaCyc: PWY-6433;MetaCyc: PWY-6598;MetaCyc: PWY-7036;MetaCyc: PWY-7602;MetaCyc: PWY-8041;MetaCyc: PWY-7035;MetaCyc: PWY-7725;MetaCyc: PWY-7619;MetaCyc: PWY-7601;KEGG: 00062+2.3.1.199;MetaCyc: PWY-5080	"Stearate biosynthesis I (animals)";"Synthesis of very long-chain fatty acyl-CoAs";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Hydroxylated fatty acid biosynthesis (plants)";"Sciadonate biosynthesis";"Very long chain fatty acid biosynthesis II";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Ultra-long-chain fatty acid biosynthesis";"(9Z)-tricosene biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Juniperonate biosynthesis";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Fatty acid elongation";"Very long chain fatty acid biosynthesis I"
XP_046416903.1	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
XP_046430679.1	3	MetaCyc: PWY-3961;KEGG: 00770+2.7.1.33;Reactome: R-HSA-196783	"Phosphopantothenate biosynthesis II";"Pantothenate and CoA biosynthesis";"Coenzyme A biosynthesis"
XP_046428563.1	3	Reactome: R-HSA-749476;Reactome: R-HSA-76066;Reactome: R-HSA-76061	"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Transcription Initiation From Type 1 Promoter"
XP_046422620.1	6	KEGG: 00073+1.2.1.84;MetaCyc: PWY-7656;MetaCyc: PWY-6733;Reactome: R-HSA-9640463;MetaCyc: PWY-5884;MetaCyc: PWY-7782	"Cutin, suberine and wax biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Sporopollenin precursors biosynthesis";"Wax biosynthesis";"Wax esters biosynthesis I";"Plasmalogen biosynthesis"
XP_046432157.1	1	Reactome: R-HSA-390522	"Striated Muscle Contraction"
XP_046435897.1	3	Reactome: R-HSA-8963901;Reactome: R-HSA-6807878;Reactome: R-HSA-445095	"Chylomicron remodeling";"COPI-mediated anterograde transport";"Interaction between L1 and Ankyrins"
XP_046426253.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_046409895.1	4	Reactome: R-HSA-166058;Reactome: R-HSA-6799198;Reactome: R-HSA-975138;Reactome: R-HSA-975871	"MyD88:MAL(TIRAP) cascade initiated on plasma membrane";"Complex I biogenesis";"TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation";"MyD88 cascade initiated on plasma membrane"
XP_046413282.1	16	Reactome: R-HSA-9022692;Reactome: R-HSA-5687128;Reactome: R-HSA-8853884;Reactome: R-HSA-2559580;Reactome: R-HSA-9029569;Reactome: R-HSA-426496;Reactome: R-HSA-8934593;Reactome: R-HSA-4086398;Reactome: R-HSA-9018519;Reactome: R-HSA-8936459;Reactome: R-HSA-8986944;Reactome: R-HSA-1912408;Reactome: R-HSA-8943723;Reactome: R-HSA-5628897;Reactome: R-HSA-8948700;Reactome: R-HSA-2559585	"Regulation of MECP2 expression and activity";"MAPK6/MAPK4 signaling";"Transcriptional Regulation by VENTX";"Oxidative Stress Induced Senescence";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Post-transcriptional silencing by small RNAs";"Regulation of RUNX1 Expression and Activity";"Ca2+ pathway";"Estrogen-dependent gene expression";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Transcriptional Regulation by MECP2";"Pre-NOTCH Transcription and Translation";"Regulation of PTEN mRNA translation";"TP53 Regulates Metabolic Genes";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"Oncogene Induced Senescence"
XP_046410135.1	6	Reactome: R-HSA-1855183;Reactome: R-HSA-1660499;KEGG: 04070+3.1.3.66;Reactome: R-HSA-1660516;KEGG: 00562+3.1.3.66;MetaCyc: PWY-6368	"Synthesis of IP2, IP, and Ins in the cytosol";"Synthesis of PIPs at the plasma membrane";"Phosphatidylinositol signaling system";"Synthesis of PIPs at the early endosome membrane";"Inositol phosphate metabolism";"3-phosphoinositide degradation"
XP_046420761.1	19	Reactome: R-HSA-6791226;Reactome: R-HSA-975956;Reactome: R-HSA-5389840;Reactome: R-HSA-72702;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-5419276;Reactome: R-HSA-9633012;Reactome: R-HSA-72706;Reactome: R-HSA-2408557;Reactome: R-HSA-975957;Reactome: R-HSA-72649;Reactome: R-HSA-72764;Reactome: R-HSA-156902;Reactome: R-HSA-5368286;Reactome: R-HSA-192823;Reactome: R-HSA-72689;Reactome: R-HSA-1799339;Reactome: R-HSA-72695	"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Mitochondrial translation elongation";"Ribosomal scanning and start codon recognition";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Mitochondrial translation termination";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Selenocysteine synthesis";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Translation initiation complex formation";"Eukaryotic Translation Termination";"Peptide chain elongation";"Mitochondrial translation initiation";"Viral mRNA Translation";"Formation of a pool of free 40S subunits";"SRP-dependent cotranslational protein targeting to membrane";"Formation of the ternary complex, and subsequently, the 43S complex"
XP_046434230.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_046414596.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046430141.1	4	Reactome: R-HSA-400511;Reactome: R-HSA-1799339;Reactome: R-HSA-422085;Reactome: R-HSA-381771	"Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)";"SRP-dependent cotranslational protein targeting to membrane";"Synthesis, secretion, and deacylation of Ghrelin";"Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)"
XP_046413960.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046419232.1	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
XP_046413623.1	1	Reactome: R-HSA-6809371	"Formation of the cornified envelope"
XP_046426805.1	1	Reactome: R-HSA-3214858	"RMTs methylate histone arginines"
XP_046431018.1	4	KEGG: 04658+3.1.3.16;Reactome: R-HSA-180024;KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16	"Th1 and Th2 cell differentiation";"DARPP-32 events";"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
XP_046432998.1	2	Reactome: R-HSA-1799339;Reactome: R-HSA-381038	"SRP-dependent cotranslational protein targeting to membrane";"XBP1(S) activates chaperone genes"
XP_046413657.1	1	Reactome: R-HSA-9609523	"Insertion of tail-anchored proteins into the endoplasmic reticulum membrane"
XP_046409934.1	14	MetaCyc: PWY-8055;MetaCyc: PWY-8051;MetaCyc: PWY-6453;Reactome: R-HSA-75109;KEGG: 00565+3.1.3.4;Reactome: R-HSA-4419969;MetaCyc: PWY-8052;Reactome: R-HSA-1483213;MetaCyc: PWY-8053;KEGG: 00561+3.1.3.4;MetaCyc: PWY-7782;KEGG: 00600+3.1.3.4;KEGG: 00564+3.1.3.4;Reactome: R-HSA-1483191	"Palmitoyl ethanolamide biosynthesis";"Anandamide biosynthesis I";"Stigma estolide biosynthesis";"Triglyceride biosynthesis";"Ether lipid metabolism";"Depolymerisation of the Nuclear Lamina";"2-arachidonoylglycerol biosynthesis";"Synthesis of PE";"Anandamide biosynthesis II";"Glycerolipid metabolism";"Plasmalogen biosynthesis";"Sphingolipid metabolism";"Glycerophospholipid metabolism";"Synthesis of PC"
XP_046435253.1	3	KEGG: 00730+3.1.3.2;KEGG: 00740+3.1.3.2;MetaCyc: PWY-6348	"Thiamine metabolism";"Riboflavin metabolism";"Phosphate acquisition"
XP_046423259.1	17	MetaCyc: PWY-5743;Reactome: R-HSA-2426168;KEGG: 00720+6.4.1.2;MetaCyc: PWY-6679;MetaCyc: PWY-5966-1;Reactome: R-HSA-200425;KEGG: 00640+6.4.1.2;Reactome: R-HSA-196780;MetaCyc: PWY-4381;KEGG: 00061+6.4.1.2;Reactome: R-HSA-3371599;MetaCyc: PWY-5789;MetaCyc: PWY-5744;MetaCyc: PWY-6722;KEGG: 00254+6.4.1.2;KEGG: 00620+6.4.1.2;Reactome: R-HSA-163765	"3-hydroxypropanoate cycle";"Activation of gene expression by SREBF (SREBP)";"Carbon fixation pathways in prokaryotes";"Jadomycin biosynthesis";"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)";"Carnitine metabolism";"Propanoate metabolism";"Biotin transport and metabolism";"Fatty acid biosynthesis initiation (bacteria and plants)";"Fatty acid biosynthesis";"Defective HLCS causes multiple carboxylase deficiency";"3-hydroxypropanoate/4-hydroxybutanate cycle";"Glyoxylate assimilation";"Candicidin biosynthesis";"Aflatoxin biosynthesis";"Pyruvate metabolism";"ChREBP activates metabolic gene expression"
XP_046435454.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046409978.1	2	Reactome: R-HSA-8939243;Reactome: R-HSA-3214858	"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RMTs methylate histone arginines"
XP_046420671.1	2	KEGG: 00230+2.7.6.1;KEGG: 00030+2.7.6.1	"Purine metabolism";"Pentose phosphate pathway"
XP_046409945.1	2	Reactome: R-HSA-71403;Reactome: R-HSA-611105	"Citric acid cycle (TCA cycle)";"Respiratory electron transport"
XP_046419596.1	3	KEGG: 00052+5.1.3.3;KEGG: 00010+5.1.3.3;MetaCyc: PWY-6317	"Galactose metabolism";"Glycolysis / Gluconeogenesis";"D-galactose degradation I (Leloir pathway)"
XP_046417256.1	2	KEGG: 00760+2.3.1.286;Reactome: R-HSA-2151201	"Nicotinate and nicotinamide metabolism";"Transcriptional activation of mitochondrial biogenesis"
XP_046430729.1	2	Reactome: R-HSA-3214858;Reactome: R-HSA-8939243	"RMTs methylate histone arginines";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"
XP_046421021.1	6	MetaCyc: PWY-7782;MetaCyc: PWY-5884;MetaCyc: PWY-7656;KEGG: 00073+1.2.1.84;Reactome: R-HSA-9640463;MetaCyc: PWY-6733	"Plasmalogen biosynthesis";"Wax esters biosynthesis I";"Spodoptera littoralis pheromone biosynthesis";"Cutin, suberine and wax biosynthesis";"Wax biosynthesis";"Sporopollenin precursors biosynthesis"
XP_046416929.1	1	Reactome: R-HSA-6811440	"Retrograde transport at the Trans-Golgi-Network"
XP_046416817.1	5	KEGG: 00785+2.3.1.181;Reactome: R-HSA-389661;MetaCyc: PWY-6987;MetaCyc: PWY-7382;KEGG: 00785+6.3.1.20	"Lipoic acid metabolism";"Glyoxylate metabolism and glycine degradation";"Lipoate biosynthesis and incorporation III (Bacillus)";"Lipoate biosynthesis and incorporation IV (yeast)";"Lipoic acid metabolism"
XP_046418394.1	1	Reactome: R-HSA-204005	"COPII-mediated vesicle transport"
XP_046412169.1	3	Reactome: R-HSA-196757;MetaCyc: PWY-2161;KEGG: 00790+6.3.2.17	"Metabolism of folate and pterines";"Folate polyglutamylation";"Folate biosynthesis"
XP_046414354.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046429453.1	4	Reactome: R-HSA-3928662;Reactome: R-HSA-8856828;Reactome: R-HSA-5663213;Reactome: R-HSA-2029482	"EPHB-mediated forward signaling";"Clathrin-mediated endocytosis";"RHO GTPases Activate WASPs and WAVEs";"Regulation of actin dynamics for phagocytic cup formation"
XP_046429301.1	1	Reactome: R-HSA-400253	"Circadian Clock"
XP_046413314.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046434588.1	22	Reactome: R-HSA-195253;Reactome: R-HSA-5358752;Reactome: R-HSA-2467813;Reactome: R-HSA-141444;Reactome: R-HSA-5358751;Reactome: R-HSA-9648025;Reactome: R-HSA-5467340;Reactome: R-HSA-5358747;Reactome: R-HSA-6811558;Reactome: R-HSA-389513;Reactome: R-HSA-2500257;Reactome: R-HSA-5673000;Reactome: R-HSA-68877;Reactome: R-HSA-5339716;Reactome: R-HSA-4641262;Reactome: R-HSA-5675221;Reactome: R-HSA-432142;Reactome: R-HSA-5358749;Reactome: R-HSA-196299;Reactome: R-HSA-5467348;Reactome: R-HSA-5663220;Reactome: R-HSA-5467337	"Degradation of beta-catenin by the destruction complex";"T41 mutants of beta-catenin aren't phosphorylated";"Separation of Sister Chromatids";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"S45 mutants of beta-catenin aren't phosphorylated";"EML4 and NUDC in mitotic spindle formation";"AXIN missense mutants destabilize the destruction complex";"S33 mutants of beta-catenin aren't phosphorylated";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"CTLA4 inhibitory signaling";"Resolution of Sister Chromatid Cohesion";"RAF activation";"Mitotic Prometaphase";"Misspliced GSK3beta mutants stabilize beta-catenin";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"Negative regulation of MAPK pathway";"Platelet sensitization by LDL";"S37 mutants of beta-catenin aren't phosphorylated";"Beta-catenin phosphorylation cascade";"Truncations of AMER1 destabilize the destruction complex";"RHO GTPases Activate Formins";"APC truncation mutants have impaired AXIN binding"
XP_046428182.1	3	Reactome: R-HSA-5578775;Reactome: R-HSA-418359;Reactome: R-HSA-425561	"Ion homeostasis";"Reduction of cytosolic Ca++ levels";"Sodium/Calcium exchangers"
XP_046409936.1	14	Reactome: R-HSA-75109;Reactome: R-HSA-4419969;KEGG: 00565+3.1.3.4;MetaCyc: PWY-8052;MetaCyc: PWY-8055;MetaCyc: PWY-8051;MetaCyc: PWY-6453;KEGG: 00600+3.1.3.4;Reactome: R-HSA-1483191;KEGG: 00564+3.1.3.4;Reactome: R-HSA-1483213;KEGG: 00561+3.1.3.4;MetaCyc: PWY-8053;MetaCyc: PWY-7782	"Triglyceride biosynthesis";"Depolymerisation of the Nuclear Lamina";"Ether lipid metabolism";"2-arachidonoylglycerol biosynthesis";"Palmitoyl ethanolamide biosynthesis";"Anandamide biosynthesis I";"Stigma estolide biosynthesis";"Sphingolipid metabolism";"Synthesis of PC";"Glycerophospholipid metabolism";"Synthesis of PE";"Glycerolipid metabolism";"Anandamide biosynthesis II";"Plasmalogen biosynthesis"
XP_046412740.1	1	Reactome: R-HSA-1799339	"SRP-dependent cotranslational protein targeting to membrane"
XP_046416127.1	1	Reactome: R-HSA-6802952	"Signaling by BRAF and RAF fusions"
XP_046425439.1	2	Reactome: R-HSA-917729;Reactome: R-HSA-162588	"Endosomal Sorting Complex Required For Transport (ESCRT)";"Budding and maturation of HIV virion"
XP_046410698.1	16	Reactome: R-HSA-174184;Reactome: R-HSA-176407;Reactome: R-HSA-176408;Reactome: R-HSA-69017;Reactome: R-HSA-174154;Reactome: R-HSA-2559582;Reactome: R-HSA-174178;Reactome: R-HSA-2467813;Reactome: R-HSA-983168;Reactome: R-HSA-141430;Reactome: R-HSA-174048;Reactome: R-HSA-179409;Reactome: R-HSA-176412;Reactome: R-HSA-174084;Reactome: R-HSA-8853884;Reactome: R-HSA-176409	"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"Regulation of APC/C activators between G1/S and early anaphase";"CDK-mediated phosphorylation and removal of Cdc6";"APC/C:Cdc20 mediated degradation of Securin";"Senescence-Associated Secretory Phenotype (SASP)";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Separation of Sister Chromatids";"Antigen processing: Ubiquitination & Proteasome degradation";"Inactivation of APC/C via direct inhibition of the APC/C complex";"APC/C:Cdc20 mediated degradation of Cyclin B";"APC-Cdc20 mediated degradation of Nek2A";"Phosphorylation of the APC/C";"Autodegradation of Cdh1 by Cdh1:APC/C";"Transcriptional Regulation by VENTX";"APC/C:Cdc20 mediated degradation of mitotic proteins"
XP_046413747.1	27	Reactome: R-HSA-168271;Reactome: R-HSA-168333;Reactome: R-HSA-159227;Reactome: R-HSA-168276;Reactome: R-HSA-3301854;Reactome: R-HSA-5619107;Reactome: R-HSA-5578749;Reactome: R-HSA-180746;Reactome: R-HSA-159230;Reactome: R-HSA-191859;Reactome: R-HSA-4615885;Reactome: R-HSA-3232142;Reactome: R-HSA-170822;Reactome: R-HSA-3371453;Reactome: R-HSA-180910;Reactome: R-HSA-4551638;Reactome: R-HSA-6784531;Reactome: R-HSA-4085377;Reactome: R-HSA-165054;Reactome: R-HSA-4570464;Reactome: R-HSA-9610379;Reactome: R-HSA-159236;Reactome: R-HSA-9609690;Reactome: R-HSA-159231;Reactome: R-HSA-1169408;Reactome: R-HSA-168325;Reactome: R-HSA-3108214	"Transport of Ribonucleoproteins into the Host Nucleus";"NEP/NS2 Interacts with the Cellular Export Machinery";"Transport of the SLBP independent Mature mRNA";"NS1 Mediated Effects on Host Pathways";"Nuclear Pore Complex (NPC) Disassembly";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Transcriptional regulation by small RNAs";"Nuclear import of Rev protein";"Transport of the SLBP Dependant Mature mRNA";"snRNP Assembly";"SUMOylation of DNA replication proteins";"SUMOylation of ubiquitinylation proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Regulation of HSF1-mediated heat shock response";"Vpr-mediated nuclear import of PICs";"SUMOylation of chromatin organization proteins";"tRNA processing in the nucleus";"SUMOylation of SUMOylation proteins";"Rev-mediated nuclear export of HIV RNA";"SUMOylation of RNA binding proteins";"HCMV Late Events";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"HCMV Early Events";"Transport of Mature mRNA Derived from an Intronless Transcript";"ISG15 antiviral mechanism";"Viral Messenger RNA Synthesis";"SUMOylation of DNA damage response and repair proteins"
XP_046428303.1	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
XP_046432715.1	6	Reactome: R-HSA-975578;MetaCyc: PWY-7426;KEGG: 00510+2.4.1.143;Reactome: R-HSA-4793952;MetaCyc: PWY-7920;KEGG: 00513+2.4.1.143	"Reactions specific to the complex N-glycan synthesis pathway";"Complex N-linked glycan biosynthesis (vertebrates)";"N-Glycan biosynthesis";"Defective MGAT2 causes MGAT2-CDG (CDG-2a)";"Complex N-linked glycan biosynthesis (plants)";"Various types of N-glycan biosynthesis"
XP_046417404.1	1	Reactome: R-HSA-432047	"Passive transport by Aquaporins"
XP_046421282.1	7	KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1	"Human cytomegalovirus infection";"Thermogenesis";"Relaxin signaling pathway";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"PI3K-Akt signaling pathway";"mTOR signaling pathway"
XP_046423448.1	1	Reactome: R-HSA-9617828	"FOXO-mediated transcription of cell cycle genes"
XP_046435864.1	2	Reactome: R-HSA-6804115;Reactome: R-HSA-429947	"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Deadenylation of mRNA"
XP_046410837.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_046417179.1	9	Reactome: R-HSA-1989781;Reactome: R-HSA-191859;Reactome: R-HSA-400206;Reactome: R-HSA-400253;Reactome: R-HSA-1368082;Reactome: R-HSA-381340;Reactome: R-HSA-1368108;Reactome: R-HSA-2151201;Reactome: R-HSA-2426168	"PPARA activates gene expression";"snRNP Assembly";"Regulation of lipid metabolism by PPARalpha";"Circadian Clock";"RORA activates gene expression";"Transcriptional regulation of white adipocyte differentiation";"BMAL1:CLOCK,NPAS2 activates circadian gene expression";"Transcriptional activation of mitochondrial biogenesis";"Activation of gene expression by SREBF (SREBP)"
XP_046418380.1	2	KEGG: 00520+5.4.2.10;MetaCyc: PWY-6749	"Amino sugar and nucleotide sugar metabolism";"CMP-legionaminate biosynthesis I"
XP_046428749.1	5	Reactome: R-HSA-166166;Reactome: R-HSA-937072;Reactome: R-HSA-936964;Reactome: R-HSA-937041;Reactome: R-HSA-168164	"MyD88-independent TLR4 cascade";"TRAF6-mediated induction of TAK1 complex within TLR4 complex";"Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon";"IKK complex recruitment mediated by RIP1";"Toll Like Receptor 3 (TLR3) Cascade"
XP_046419536.1	27	Reactome: R-HSA-180910;Reactome: R-HSA-3371453;Reactome: R-HSA-3232142;Reactome: R-HSA-170822;Reactome: R-HSA-4551638;Reactome: R-HSA-4085377;Reactome: R-HSA-6784531;Reactome: R-HSA-165054;Reactome: R-HSA-4570464;Reactome: R-HSA-9610379;Reactome: R-HSA-9609690;Reactome: R-HSA-168325;Reactome: R-HSA-3108214;Reactome: R-HSA-159231;Reactome: R-HSA-1169408;Reactome: R-HSA-159236;Reactome: R-HSA-168271;Reactome: R-HSA-159227;Reactome: R-HSA-168333;Reactome: R-HSA-168276;Reactome: R-HSA-3301854;Reactome: R-HSA-5619107;Reactome: R-HSA-4615885;Reactome: R-HSA-5578749;Reactome: R-HSA-159230;Reactome: R-HSA-180746;Reactome: R-HSA-191859	"Vpr-mediated nuclear import of PICs";"Regulation of HSF1-mediated heat shock response";"SUMOylation of ubiquitinylation proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"SUMOylation of chromatin organization proteins";"SUMOylation of SUMOylation proteins";"tRNA processing in the nucleus";"Rev-mediated nuclear export of HIV RNA";"SUMOylation of RNA binding proteins";"HCMV Late Events";"HCMV Early Events";"Viral Messenger RNA Synthesis";"SUMOylation of DNA damage response and repair proteins";"Transport of Mature mRNA Derived from an Intronless Transcript";"ISG15 antiviral mechanism";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Transport of Ribonucleoproteins into the Host Nucleus";"Transport of the SLBP independent Mature mRNA";"NEP/NS2 Interacts with the Cellular Export Machinery";"NS1 Mediated Effects on Host Pathways";"Nuclear Pore Complex (NPC) Disassembly";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"SUMOylation of DNA replication proteins";"Transcriptional regulation by small RNAs";"Transport of the SLBP Dependant Mature mRNA";"Nuclear import of Rev protein";"snRNP Assembly"
XP_046426434.1	9	Reactome: R-HSA-5689880;Reactome: R-HSA-9613829;Reactome: R-HSA-8856825;Reactome: R-HSA-9615710;Reactome: R-HSA-8856828;Reactome: R-HSA-5678895;Reactome: R-HSA-9646399;Reactome: R-HSA-382556;Reactome: R-HSA-5627083	"Ub-specific processing proteases";"Chaperone Mediated Autophagy";"Cargo recognition for clathrin-mediated endocytosis";"Late endosomal microautophagy";"Clathrin-mediated endocytosis";"Defective CFTR causes cystic fibrosis";"Aggrephagy";"ABC-family proteins mediated transport";"RHO GTPases regulate CFTR trafficking"
XP_046428211.1	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
XP_046410262.1	2	Reactome: R-HSA-5678895;Reactome: R-HSA-382556	"Defective CFTR causes cystic fibrosis";"ABC-family proteins mediated transport"
XP_046413237.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_046412210.1	9	Reactome: R-HSA-68827;Reactome: R-HSA-69017;Reactome: R-HSA-176187;Reactome: R-HSA-68962;Reactome: R-HSA-68949;Reactome: R-HSA-68867;Reactome: R-HSA-69205;Reactome: R-HSA-1362277;Reactome: R-HSA-68689	"CDT1 association with the CDC6:ORC:origin complex";"CDK-mediated phosphorylation and removal of Cdc6";"Activation of ATR in response to replication stress";"Activation of the pre-replicative complex";"Orc1 removal from chromatin";"Assembly of the pre-replicative complex";"G1/S-Specific Transcription";"Transcription of E2F targets under negative control by DREAM complex";"CDC6 association with the ORC:origin complex"
XP_046430519.1	7	Reactome: R-HSA-5663220;Reactome: R-HSA-2500257;Reactome: R-HSA-68877;Reactome: R-HSA-2467813;Reactome: R-HSA-9648025;Reactome: R-HSA-141444;Reactome: R-HSA-606279	"RHO GTPases Activate Formins";"Resolution of Sister Chromatid Cohesion";"Mitotic Prometaphase";"Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Deposition of new CENPA-containing nucleosomes at the centromere"
XP_046424998.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_046413895.1	25	Reactome: R-HSA-456926;Reactome: R-HSA-202040;Reactome: R-HSA-418594;Reactome: R-HSA-392451;Reactome: R-HSA-381771;Reactome: R-HSA-6814122;Reactome: R-HSA-418217;Reactome: R-HSA-9009391;Reactome: R-HSA-163359;Reactome: R-HSA-4086398;Reactome: R-HSA-392170;Reactome: R-HSA-8964616;Reactome: R-HSA-428930;Reactome: R-HSA-381676;Reactome: R-HSA-420092;Reactome: R-HSA-8964315;Reactome: R-HSA-432040;Reactome: R-HSA-418555;Reactome: R-HSA-400042;Reactome: R-HSA-392851;Reactome: R-HSA-500657;Reactome: R-HSA-418597;Reactome: R-HSA-416476;Reactome: R-HSA-418592;Reactome: R-HSA-416482	"Thrombin signalling through proteinase activated receptors (PARs)";"G-protein activation";"G alpha (i) signalling events";"G beta:gamma signalling through PI3Kgamma";"Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"G beta:gamma signalling through PLC beta";"Extra-nuclear estrogen signaling";"Glucagon signaling in metabolic regulation";"Ca2+ pathway";"ADP signalling through P2Y purinoceptor 12";"G beta:gamma signalling through CDC42";"Thromboxane signalling through TP receptor";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"Glucagon-type ligand receptors";"G beta:gamma signalling through BTK";"Vasopressin regulates renal water homeostasis via Aquaporins";"G alpha (s) signalling events";"Adrenaline,noradrenaline inhibits insulin secretion";"Prostacyclin signalling through prostacyclin receptor";"Presynaptic function of Kainate receptors";"G alpha (z) signalling events";"G alpha (q) signalling events";"ADP signalling through P2Y purinoceptor 1";"G alpha (12/13) signalling events"
XP_046417176.1	9	Reactome: R-HSA-381340;Reactome: R-HSA-2151201;Reactome: R-HSA-2426168;Reactome: R-HSA-1368108;Reactome: R-HSA-1989781;Reactome: R-HSA-400253;Reactome: R-HSA-1368082;Reactome: R-HSA-400206;Reactome: R-HSA-191859	"Transcriptional regulation of white adipocyte differentiation";"Transcriptional activation of mitochondrial biogenesis";"Activation of gene expression by SREBF (SREBP)";"BMAL1:CLOCK,NPAS2 activates circadian gene expression";"PPARA activates gene expression";"Circadian Clock";"RORA activates gene expression";"Regulation of lipid metabolism by PPARalpha";"snRNP Assembly"
XP_046415458.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_046414552.1	1	Reactome: R-HSA-1660661	"Sphingolipid de novo biosynthesis"
XP_046424257.1	5	Reactome: R-HSA-389357;Reactome: R-HSA-5218920;Reactome: R-HSA-5674400;Reactome: R-HSA-1257604;Reactome: R-HSA-6804757	"CD28 dependent PI3K/Akt signaling";"VEGFR2 mediated vascular permeability";"Constitutive Signaling by AKT1 E17K in Cancer";"PIP3 activates AKT signaling";"Regulation of TP53 Degradation"
XP_046426909.1	1	Reactome: R-HSA-5620922	"BBSome-mediated cargo-targeting to cilium"
XP_046435659.1	1	Reactome: R-HSA-611105	"Respiratory electron transport"
XP_046430915.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046419593.1	3	MetaCyc: PWY-6317;KEGG: 00010+5.1.3.3;KEGG: 00052+5.1.3.3	"D-galactose degradation I (Leloir pathway)";"Glycolysis / Gluconeogenesis";"Galactose metabolism"
XP_046420379.1	3	Reactome: R-HSA-4420097;Reactome: R-HSA-2029482;Reactome: R-HSA-5663213	"VEGFA-VEGFR2 Pathway";"Regulation of actin dynamics for phagocytic cup formation";"RHO GTPases Activate WASPs and WAVEs"
XP_046425837.1	1	Reactome: R-HSA-196836	"Vitamin C (ascorbate) metabolism"
XP_046430191.1	2	Reactome: R-HSA-8951671;Reactome: R-HSA-2032785	"RUNX3 regulates YAP1-mediated transcription";"YAP1- and WWTR1 (TAZ)-stimulated gene expression"
XP_046430393.1	2	Reactome: R-HSA-5610787;Reactome: R-HSA-5620924	"Hedgehog 'off' state";"Intraflagellar transport"
XP_046419971.1	19	Reactome: R-HSA-399719;Reactome: R-HSA-5578775;Reactome: R-HSA-936837;Reactome: R-HSA-9609736;Reactome: R-HSA-9617324;Reactome: R-HSA-877300;Reactome: R-HSA-5576892;Reactome: R-HSA-111932;Reactome: R-HSA-9022692;Reactome: R-HSA-438066;Reactome: R-HSA-6802955;Reactome: R-HSA-6802952;Reactome: R-HSA-9649948;Reactome: R-HSA-3371571;Reactome: R-HSA-442982;Reactome: R-HSA-9620244;Reactome: R-HSA-5673000;Reactome: R-HSA-6802946;Reactome: R-HSA-5673001	"Trafficking of AMPA receptors";"Ion homeostasis";"Ion transport by P-type ATPases";"Assembly and cell surface presentation of NMDA receptors";"Negative regulation of NMDA receptor-mediated neuronal transmission";"Interferon gamma signaling";"Phase 0 - rapid depolarisation";"CaMK IV-mediated phosphorylation of CREB";"Regulation of MECP2 expression and activity";"Unblocking of NMDA receptors, glutamate binding and activation";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"Signaling by BRAF and RAF fusions";"Signaling downstream of RAS mutants";"HSF1-dependent transactivation";"Ras activation upon Ca2+ influx through NMDA receptor";"Long-term potentiation";"RAF activation";"Signaling by moderate kinase activity BRAF mutants";"RAF/MAP kinase cascade"
XP_046413554.1	12	Reactome: R-HSA-3371497;Reactome: R-HSA-6807878;Reactome: R-HSA-2500257;Reactome: R-HSA-5663220;Reactome: R-HSA-141444;Reactome: R-HSA-9648025;Reactome: R-HSA-9646399;Reactome: R-HSA-2467813;Reactome: R-HSA-6811436;Reactome: R-HSA-68877;Reactome: R-HSA-9609690;Reactome: R-HSA-2132295	"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-mediated anterograde transport";"Resolution of Sister Chromatid Cohesion";"RHO GTPases Activate Formins";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"EML4 and NUDC in mitotic spindle formation";"Aggrephagy";"Separation of Sister Chromatids";"COPI-independent Golgi-to-ER retrograde traffic";"Mitotic Prometaphase";"HCMV Early Events";"MHC class II antigen presentation"
XP_046416142.1	10	MetaCyc: PWY-8053;KEGG: 00564+2.3.1.15;MetaCyc: PWY-5667;KEGG: 00561+2.3.1.15;MetaCyc: PWY-6453;MetaCyc: PWY-8051;MetaCyc: PWY-8055;MetaCyc: PWY-7587;Reactome: R-HSA-1483166;MetaCyc: PWY-7411	"Anandamide biosynthesis II";"Glycerophospholipid metabolism";"CDP-diacylglycerol biosynthesis I";"Glycerolipid metabolism";"Stigma estolide biosynthesis";"Anandamide biosynthesis I";"Palmitoyl ethanolamide biosynthesis";"Oleate biosynthesis III (cyanobacteria)";"Synthesis of PA";"Phosphatidate biosynthesis (yeast)"
XP_046431791.1	11	KEGG: 00564+3.1.3.4;KEGG: 00600+3.1.3.4;KEGG: 00561+3.1.3.4;MetaCyc: PWY-8053;MetaCyc: PWY-7782;KEGG: 00565+3.1.3.4;MetaCyc: PWY-8052;Reactome: R-HSA-2029485;MetaCyc: PWY-6453;MetaCyc: PWY-8051;MetaCyc: PWY-8055	"Glycerophospholipid metabolism";"Sphingolipid metabolism";"Glycerolipid metabolism";"Anandamide biosynthesis II";"Plasmalogen biosynthesis";"Ether lipid metabolism";"2-arachidonoylglycerol biosynthesis";"Role of phospholipids in phagocytosis";"Stigma estolide biosynthesis";"Anandamide biosynthesis I";"Palmitoyl ethanolamide biosynthesis"
XP_046423855.1	1	Reactome: R-HSA-71384	"Ethanol oxidation"
XP_046430114.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046431104.1	13	KEGG: 00720+4.2.1.2;KEGG: 00620+4.2.1.2;MetaCyc: PWY-7384;MetaCyc: PWY-5690;Reactome: R-HSA-71403;MetaCyc: PWY-8086;MetaCyc: PWY-7254;MetaCyc: PWY-5392;MetaCyc: PWY-561;MetaCyc: PWY-6969;KEGG: 00020+4.2.1.2;MetaCyc: PWY-5913;MetaCyc: PWY-6728	"Carbon fixation pathways in prokaryotes";"Pyruvate metabolism";"Anaerobic energy metabolism (invertebrates, mitochondrial)";"TCA cycle II (plants and fungi)";"Citric acid cycle (TCA cycle)";"(S)-lactate fermentation to propanoate, acetate and hydrogen";"TCA cycle VII (acetate-producers)";"Reductive TCA cycle II";"Superpathway of glyoxylate cycle and fatty acid degradation";"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Citrate cycle (TCA cycle)";"Partial TCA cycle (obligate autotrophs)";"Methylaspartate cycle"
XP_046413498.1	11	Reactome: R-HSA-432040;Reactome: R-HSA-418594;Reactome: R-HSA-170670;KEGG: 00230+4.6.1.1;Reactome: R-HSA-5610787;Reactome: R-HSA-163615;Reactome: R-HSA-163359;Reactome: R-HSA-164378;Reactome: R-HSA-170660;Reactome: R-HSA-418597;Reactome: R-HSA-418555	"Vasopressin regulates renal water homeostasis via Aquaporins";"G alpha (i) signalling events";"Adenylate cyclase inhibitory pathway";"Purine metabolism";"Hedgehog 'off' state";"PKA activation";"Glucagon signaling in metabolic regulation";"PKA activation in glucagon signalling";"Adenylate cyclase activating pathway";"G alpha (z) signalling events";"G alpha (s) signalling events"
XP_046435696.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046418391.1	1	Reactome: R-HSA-204005	"COPII-mediated vesicle transport"
XP_046429450.1	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
XP_046421233.1	13	MetaCyc: PWY-6969;MetaCyc: PWY-5538;MetaCyc: PWY-6728;MetaCyc: PWY-5913;KEGG: 00640+6.2.1.5;KEGG: 00660+6.2.1.5;MetaCyc: PWY-5392;MetaCyc: PWY-5537;KEGG: 00720+6.2.1.5;KEGG: 00020+6.2.1.5;MetaCyc: PWY-5690;Reactome: R-HSA-71403;MetaCyc: PWY-7384	"TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase)";"Pyruvate fermentation to acetate VI";"Methylaspartate cycle";"Partial TCA cycle (obligate autotrophs)";"Propanoate metabolism";"C5-Branched dibasic acid metabolism";"Reductive TCA cycle II";"Pyruvate fermentation to acetate V";"Carbon fixation pathways in prokaryotes";"Citrate cycle (TCA cycle)";"TCA cycle II (plants and fungi)";"Citric acid cycle (TCA cycle)";"Anaerobic energy metabolism (invertebrates, mitochondrial)"
XP_046411091.1	3	Reactome: R-HSA-9018519;Reactome: R-HSA-381340;Reactome: R-HSA-1989781	"Estrogen-dependent gene expression";"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression"
XP_046434498.1	2	Reactome: R-HSA-430039;MetaCyc: PWY-6938	"mRNA decay by 5' to 3' exoribonuclease";"NADH repair"
XP_046414898.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046419932.1	19	Reactome: R-HSA-5673000;Reactome: R-HSA-6802946;Reactome: R-HSA-9620244;Reactome: R-HSA-5673001;Reactome: R-HSA-3371571;Reactome: R-HSA-9649948;Reactome: R-HSA-6802952;Reactome: R-HSA-442982;Reactome: R-HSA-6802955;Reactome: R-HSA-5576892;Reactome: R-HSA-877300;Reactome: R-HSA-9617324;Reactome: R-HSA-438066;Reactome: R-HSA-9022692;Reactome: R-HSA-111932;Reactome: R-HSA-9609736;Reactome: R-HSA-5578775;Reactome: R-HSA-399719;Reactome: R-HSA-936837	"RAF activation";"Signaling by moderate kinase activity BRAF mutants";"Long-term potentiation";"RAF/MAP kinase cascade";"HSF1-dependent transactivation";"Signaling downstream of RAS mutants";"Signaling by BRAF and RAF fusions";"Ras activation upon Ca2+ influx through NMDA receptor";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"Phase 0 - rapid depolarisation";"Interferon gamma signaling";"Negative regulation of NMDA receptor-mediated neuronal transmission";"Unblocking of NMDA receptors, glutamate binding and activation";"Regulation of MECP2 expression and activity";"CaMK IV-mediated phosphorylation of CREB";"Assembly and cell surface presentation of NMDA receptors";"Ion homeostasis";"Trafficking of AMPA receptors";"Ion transport by P-type ATPases"
XP_046426736.1	8	Reactome: R-HSA-8943724;Reactome: R-HSA-9639288;Reactome: R-HSA-5628897;Reactome: R-HSA-3371571;Reactome: R-HSA-380972;Reactome: R-HSA-165159;Reactome: R-HSA-166208;Reactome: R-HSA-1632852	"Regulation of PTEN gene transcription";"Amino acids regulate mTORC1";"TP53 Regulates Metabolic Genes";"HSF1-dependent transactivation";"Energy dependent regulation of mTOR by LKB1-AMPK";"mTOR signalling";"mTORC1-mediated signalling";"Macroautophagy"
XP_046414179.1	4	Reactome: R-HSA-1614558;KEGG: 00430+1.13.11.20;KEGG: 00270+1.13.11.20;MetaCyc: PWY-5331	"Degradation of cysteine and homocysteine";"Taurine and hypotaurine metabolism";"Cysteine and methionine metabolism";"Taurine biosynthesis I"
XP_046424507.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_046429313.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_046426222.1	1	Reactome: R-HSA-6803157	"Antimicrobial peptides"
XP_046427491.1	2	Reactome: R-HSA-5576892;Reactome: R-HSA-5576893	"Phase 0 - rapid depolarisation";"Phase 2 - plateau phase"
XP_046433023.1	10	Reactome: R-HSA-350054;Reactome: R-HSA-2644606;Reactome: R-HSA-9013508;Reactome: R-HSA-2122947;Reactome: R-HSA-210744;Reactome: R-HSA-1912408;Reactome: R-HSA-9013695;Reactome: R-HSA-8941856;Reactome: R-HSA-2894862;Reactome: R-HSA-2197563	"Notch-HLH transcription pathway";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH3 Intracellular Domain Regulates Transcription";"NOTCH1 Intracellular Domain Regulates Transcription";"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"Pre-NOTCH Transcription and Translation";"NOTCH4 Intracellular Domain Regulates Transcription";"RUNX3 regulates NOTCH signaling";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"NOTCH2 intracellular domain regulates transcription"
XP_046417800.1	5	Reactome: R-HSA-8939243;Reactome: R-HSA-201722;Reactome: R-HSA-1266695;Reactome: R-HSA-3214858;Reactome: R-HSA-3247509	"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"Formation of the beta-catenin:TCF transactivating complex";"Interleukin-7 signaling";"RMTs methylate histone arginines";"Chromatin modifying enzymes"
XP_046425546.1	27	Reactome: R-HSA-4570464;Reactome: R-HSA-9610379;Reactome: R-HSA-9609690;Reactome: R-HSA-168325;Reactome: R-HSA-159231;Reactome: R-HSA-3108214;Reactome: R-HSA-1169408;Reactome: R-HSA-159236;Reactome: R-HSA-180910;Reactome: R-HSA-3371453;Reactome: R-HSA-170822;Reactome: R-HSA-3232142;Reactome: R-HSA-4551638;Reactome: R-HSA-4085377;Reactome: R-HSA-165054;Reactome: R-HSA-6784531;Reactome: R-HSA-168276;Reactome: R-HSA-3301854;Reactome: R-HSA-5619107;Reactome: R-HSA-4615885;Reactome: R-HSA-159230;Reactome: R-HSA-180746;Reactome: R-HSA-5578749;Reactome: R-HSA-191859;Reactome: R-HSA-168271;Reactome: R-HSA-159227;Reactome: R-HSA-168333	"SUMOylation of RNA binding proteins";"HCMV Late Events";"HCMV Early Events";"Viral Messenger RNA Synthesis";"Transport of Mature mRNA Derived from an Intronless Transcript";"SUMOylation of DNA damage response and repair proteins";"ISG15 antiviral mechanism";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Vpr-mediated nuclear import of PICs";"Regulation of HSF1-mediated heat shock response";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"SUMOylation of ubiquitinylation proteins";"SUMOylation of chromatin organization proteins";"SUMOylation of SUMOylation proteins";"Rev-mediated nuclear export of HIV RNA";"tRNA processing in the nucleus";"NS1 Mediated Effects on Host Pathways";"Nuclear Pore Complex (NPC) Disassembly";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"SUMOylation of DNA replication proteins";"Transport of the SLBP Dependant Mature mRNA";"Nuclear import of Rev protein";"Transcriptional regulation by small RNAs";"snRNP Assembly";"Transport of Ribonucleoproteins into the Host Nucleus";"Transport of the SLBP independent Mature mRNA";"NEP/NS2 Interacts with the Cellular Export Machinery"
XP_046422053.1	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
XP_046414336.1	9	Reactome: R-HSA-3656253;Reactome: R-HSA-1971475;Reactome: R-HSA-2024096;Reactome: R-HSA-3656237;Reactome: R-HSA-2022928;Reactome: R-HSA-975634;Reactome: R-HSA-3560801;Reactome: R-HSA-3560783;Reactome: R-HSA-4420332	"Defective EXT1 causes exostoses 1, TRPS2 and CHDS";"A tetrasaccharide linker sequence is required for GAG synthesis";"HS-GAG degradation";"Defective EXT2 causes exostoses 2";"HS-GAG biosynthesis";"Retinoid metabolism and transport";"Defective B3GAT3 causes JDSSDHD";"Defective B4GALT7 causes EDS, progeroid type";"Defective B3GALT6 causes EDSP2 and SEMDJL1"
XP_046424091.1	7	Reactome: R-HSA-9029569;Reactome: R-HSA-3214842;Reactome: R-HSA-983231;Reactome: R-HSA-8943724;Reactome: R-HSA-3214815;Reactome: R-HSA-5625886;Reactome: R-HSA-9018519	"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"HDMs demethylate histones";"Factors involved in megakaryocyte development and platelet production";"Regulation of PTEN gene transcription";"HDACs deacetylate histones";"Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3";"Estrogen-dependent gene expression"
XP_046429832.1	8	KEGG: 00524+2.7.1.1;KEGG: 00521+2.7.1.1;KEGG: 00051+2.7.1.1;KEGG: 00520+2.7.1.1;KEGG: 00010+2.7.1.1;Reactome: R-HSA-70171;KEGG: 00052+2.7.1.1;KEGG: 00500+2.7.1.1	"Neomycin, kanamycin and gentamicin biosynthesis";"Streptomycin biosynthesis";"Fructose and mannose metabolism";"Amino sugar and nucleotide sugar metabolism";"Glycolysis / Gluconeogenesis";"Glycolysis";"Galactose metabolism";"Starch and sucrose metabolism"
XP_046431417.1	3	Reactome: R-HSA-392154;Reactome: R-HSA-445355;KEGG: 00230+4.6.1.2	"Nitric oxide stimulates guanylate cyclase";"Smooth Muscle Contraction";"Purine metabolism"
XP_046414355.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046411228.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046415483.1	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
XP_046416139.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046427516.1	2	KEGG: 00510+2.4.1.256;Reactome: R-HSA-446193	"N-Glycan biosynthesis";"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein"
XP_046418453.1	56	Reactome: R-HSA-174184;Reactome: R-HSA-8939902;Reactome: R-HSA-174154;Reactome: R-HSA-2467813;Reactome: R-HSA-983168;Reactome: R-HSA-5658442;Reactome: R-HSA-5607761;Reactome: R-HSA-5610785;Reactome: R-HSA-5678895;Reactome: R-HSA-180585;Reactome: R-HSA-8939236;Reactome: R-HSA-349425;Reactome: R-HSA-8951664;Reactome: R-HSA-174084;Reactome: R-HSA-5689880;Reactome: R-HSA-4641257;Reactome: R-HSA-4608870;Reactome: R-HSA-75815;Reactome: R-HSA-202424;Reactome: R-HSA-1236978;Reactome: R-HSA-69601;Reactome: R-HSA-69017;Reactome: R-HSA-5358346;Reactome: R-HSA-5362768;Reactome: R-HSA-5676590;Reactome: R-HSA-9604323;Reactome: R-HSA-174178;Reactome: R-HSA-2871837;Reactome: R-HSA-195253;Reactome: R-HSA-1169091;Reactome: R-HSA-68949;Reactome: R-HSA-382556;Reactome: R-HSA-5632684;Reactome: R-HSA-4641258;Reactome: R-HSA-211733;Reactome: R-HSA-1236974;Reactome: R-HSA-5610780;Reactome: R-HSA-450408;Reactome: R-HSA-5668541;Reactome: R-HSA-8941858;Reactome: R-HSA-350562;Reactome: R-HSA-9010553;Reactome: R-HSA-5607764;Reactome: R-HSA-187577;Reactome: R-HSA-180534;Reactome: R-HSA-5689603;Reactome: R-HSA-68827;Reactome: R-HSA-8852276;Reactome: R-HSA-5610783;Reactome: R-HSA-8948751;Reactome: R-HSA-1234176;Reactome: R-HSA-69481;Reactome: R-HSA-8854050;Reactome: R-HSA-9020702;Reactome: R-HSA-5687128;Reactome: R-HSA-174113	"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Regulation of RUNX2 expression and activity";"APC/C:Cdc20 mediated degradation of Securin";"Separation of Sister Chromatids";"Antigen processing: Ubiquitination & Proteasome degradation";"Regulation of RAS by GAPs";"Dectin-1 mediated noncanonical NF-kB signaling";"GLI3 is processed to GLI3R by the proteasome";"Defective CFTR causes cystic fibrosis";"Vif-mediated degradation of APOBEC3G";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Autodegradation of the E3 ubiquitin ligase COP1";"Neddylation";"Autodegradation of Cdh1 by Cdh1:APC/C";"Ub-specific processing proteases";"Degradation of AXIN";"Asymmetric localization of PCP proteins";"Ubiquitin-dependent degradation of Cyclin D";"Downstream TCR signaling";"Cross-presentation of soluble exogenous antigens (endosomes)";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"CDK-mediated phosphorylation and removal of Cdc6";"Hedgehog ligand biogenesis";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"NIK-->noncanonical NF-kB signaling";"Negative regulation of NOTCH4 signaling";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"FCERI mediated NF-kB activation";"Degradation of beta-catenin by the destruction complex";"Activation of NF-kappaB in B cells";"Orc1 removal from chromatin";"ABC-family proteins mediated transport";"Hedgehog 'on' state";"Degradation of DVL";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"ER-Phagosome pathway";"Degradation of GLI1 by the proteasome";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"TNFR2 non-canonical NF-kB pathway";"Regulation of RUNX3 expression and activity";"Regulation of ornithine decarboxylase (ODC)";"Regulation of expression of SLITs and ROBOs";"CLEC7A (Dectin-1) signaling";"SCF(Skp2)-mediated degradation of p27/p21";"Vpu mediated degradation of CD4";"UCH proteinases";"CDT1 association with the CDC6:ORC:origin complex";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Degradation of GLI2 by the proteasome";"Regulation of PTEN stability and activity";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"G2/M Checkpoints";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Interleukin-1 signaling";"MAPK6/MAPK4 signaling";"SCF-beta-TrCP mediated degradation of Emi1"
XP_046429292.1	2	Reactome: R-HSA-196780;Reactome: R-HSA-3371599	"Biotin transport and metabolism";"Defective HLCS causes multiple carboxylase deficiency"
XP_046436249.1	2	MetaCyc: PWY-6558;Reactome: R-HSA-2022928	"Heparan sulfate biosynthesis (late stages)";"HS-GAG biosynthesis"
XP_046424508.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_046427022.1	2	KEGG: 00561+2.7.1.30;MetaCyc: PWY-4261	"Glycerolipid metabolism";"Glycerol degradation I"
XP_046427721.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_046434690.1	3	Reactome: R-HSA-74217;KEGG: 00230+3.5.4.6;MetaCyc: PWY-6596	"Purine salvage";"Purine metabolism";"Adenosine nucleotides degradation I"
XP_046429257.1	4	MetaCyc: PWY-7250;Reactome: R-HSA-1362409;KEGG: 00730+2.8.1.7;Reactome: R-HSA-947581	"[2Fe-2S] iron-sulfur cluster biosynthesis";"Mitochondrial iron-sulfur cluster biogenesis";"Thiamine metabolism";"Molybdenum cofactor biosynthesis"
XP_046417537.1	2	Reactome: R-HSA-936837;Reactome: R-HSA-6798695	"Ion transport by P-type ATPases";"Neutrophil degranulation"
XP_046409623.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_046421721.1	2	Reactome: R-HSA-2408522;Reactome: R-HSA-379716	"Selenoamino acid metabolism";"Cytosolic tRNA aminoacylation"
XP_046435527.1	2	Reactome: R-HSA-400253;Reactome: R-HSA-2151201	"Circadian Clock";"Transcriptional activation of mitochondrial biogenesis"
XP_046416374.1	2	Reactome: R-HSA-5576893;Reactome: R-HSA-5576892	"Phase 2 - plateau phase";"Phase 0 - rapid depolarisation"
XP_046430217.1	2	Reactome: R-HSA-5655302;Reactome: R-HSA-1839117	"Signaling by FGFR1 in disease";"Signaling by cytosolic FGFR1 fusion mutants"
XP_046413992.1	5	Reactome: R-HSA-9610379;Reactome: R-HSA-162588;Reactome: R-HSA-917729;Reactome: R-HSA-174490;Reactome: R-HSA-9615710	"HCMV Late Events";"Budding and maturation of HIV virion";"Endosomal Sorting Complex Required For Transport (ESCRT)";"Membrane binding and targetting of GAG proteins";"Late endosomal microautophagy"
XP_046429084.1	13	MetaCyc: PWY-5123;MetaCyc: PWY-7736;KEGG: 00900+2.5.1.10+2.5.1.1;MetaCyc: PWY-7709;MetaCyc: PWY-6383;MetaCyc: PWY-7659;MetaCyc: PWY-7141;MetaCyc: PWY-5122;MetaCyc: PWY-7721;MetaCyc: PWY-7410;MetaCyc: PWY-7182;MetaCyc: PWY-6859;MetaCyc: PWY-7102	"Trans, trans-farnesyl diphosphate biosynthesis";"Stellatic acid biosynthesis";"Terpenoid backbone biosynthesis";"(3R)-linalool biosynthesis";"Mono-trans, poly-cis decaprenyl phosphate biosynthesis";"Viridicatumtoxin biosynthesis";"(3S)-linalool biosynthesis";"Geranyl diphosphate biosynthesis";"Methyl phomopsenoate biosynthesis";"Ipsdienol biosynthesis";"Linalool biosynthesis I";"All-trans-farnesol biosynthesis";"Bisabolene biosynthesis (engineered)"
XP_046418738.1	2	Reactome: R-HSA-1660662;Reactome: R-HSA-390471	"Glycosphingolipid metabolism";"Association of TriC/CCT with target proteins during biosynthesis"
XP_046423775.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_046428439.1	7	KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1	"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Relaxin signaling pathway";"Thermogenesis";"Human cytomegalovirus infection"
XP_046427269.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046426115.1	16	Reactome: R-HSA-975138;Reactome: R-HSA-9020702;Reactome: R-HSA-1257604;Reactome: R-HSA-3134963;Reactome: R-HSA-975871;Reactome: R-HSA-209543;Reactome: R-HSA-975155;Reactome: R-HSA-5603037;Reactome: R-HSA-5603041;Reactome: R-HSA-5602680;Reactome: R-HSA-5602498;Reactome: R-HSA-1236974;Reactome: R-HSA-6811558;Reactome: R-HSA-166058;Reactome: R-HSA-1810476;Reactome: R-HSA-975110	"TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation";"Interleukin-1 signaling";"PIP3 activates AKT signaling";"DEx/H-box helicases activate type I IFN and inflammatory cytokines production";"MyD88 cascade initiated on plasma membrane";"p75NTR recruits signalling complexes";"MyD88 dependent cascade initiated on endosome";"IRAK4 deficiency (TLR5)";"IRAK4 deficiency (TLR2/4)";"MyD88 deficiency (TLR5)";"MyD88 deficiency (TLR2/4)";"ER-Phagosome pathway";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"MyD88:MAL(TIRAP) cascade initiated on plasma membrane";"RIP-mediated NFkB activation via ZBP1";"TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling"
XP_046411077.1	3	Reactome: R-HSA-9018519;Reactome: R-HSA-381340;Reactome: R-HSA-1989781	"Estrogen-dependent gene expression";"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression"
XP_046432719.1	6	Reactome: R-HSA-975578;KEGG: 00510+2.4.1.143;MetaCyc: PWY-7426;Reactome: R-HSA-4793952;MetaCyc: PWY-7920;KEGG: 00513+2.4.1.143	"Reactions specific to the complex N-glycan synthesis pathway";"N-Glycan biosynthesis";"Complex N-linked glycan biosynthesis (vertebrates)";"Defective MGAT2 causes MGAT2-CDG (CDG-2a)";"Complex N-linked glycan biosynthesis (plants)";"Various types of N-glycan biosynthesis"
XP_046433235.1	3	Reactome: R-HSA-6798695;Reactome: R-HSA-2024096;Reactome: R-HSA-2206291	"Neutrophil degranulation";"HS-GAG degradation";"MPS IIIC - Sanfilippo syndrome C"
XP_046424082.1	1	Reactome: R-HSA-5676934	"Protein repair"
XP_046418358.1	3	Reactome: R-HSA-193648;Reactome: R-HSA-416482;Reactome: R-HSA-194840	"NRAGE signals death through JNK";"G alpha (12/13) signalling events";"Rho GTPase cycle"
XP_046428648.1	1	Reactome: R-HSA-525793	"Myogenesis"
XP_046415709.1	10	Reactome: R-HSA-6804756;Reactome: R-HSA-6814122;Reactome: R-HSA-8948751;Reactome: R-HSA-2514853;Reactome: R-HSA-6798695;Reactome: R-HSA-8939243;Reactome: R-HSA-8934903;Reactome: R-HSA-445144;Reactome: R-HSA-1483191;Reactome: R-HSA-201688	"Regulation of TP53 Activity through Phosphorylation";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding";"Regulation of PTEN stability and activity";"Condensation of Prometaphase Chromosomes";"Neutrophil degranulation";"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"Receptor Mediated Mitophagy";"Signal transduction by L1";"Synthesis of PC";"WNT mediated activation of DVL"
XP_046409764.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046423851.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_046425002.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_046434555.1	1	Reactome: R-HSA-437239	"Recycling pathway of L1"
XP_046418410.1	1	Reactome: R-HSA-381038	"XBP1(S) activates chaperone genes"
XP_046413192.1	8	KEGG: 05163+2.7.11.1;Reactome: R-HSA-975957;KEGG: 04926+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1	"Human cytomegalovirus infection";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Relaxin signaling pathway";"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Thermogenesis";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection"
XP_046415191.1	4	KEGG: 00564+3.1.1.32;MetaCyc: PWY-6803;KEGG: 00592+3.1.1.32;MetaCyc: PWY-8051	"Glycerophospholipid metabolism";"Phosphatidylcholine acyl editing";"alpha-Linolenic acid metabolism";"Anandamide biosynthesis I"
XP_046409499.1	1	Reactome: R-HSA-425366	"Transport of bile salts and organic acids, metal ions and amine compounds"
XP_046411619.1	5	MetaCyc: PWY-3821;MetaCyc: PWY-6317;MetaCyc: PWY-6527;KEGG: 00520+2.7.1.6;KEGG: 00052+2.7.1.6	"D-galactose detoxification";"D-galactose degradation I (Leloir pathway)";"Stachyose degradation";"Amino sugar and nucleotide sugar metabolism";"Galactose metabolism"
XP_046436692.1	12	Reactome: R-HSA-5663220;Reactome: R-HSA-2500257;Reactome: R-HSA-3371497;Reactome: R-HSA-6807878;Reactome: R-HSA-2132295;Reactome: R-HSA-9648025;Reactome: R-HSA-141444;Reactome: R-HSA-68877;Reactome: R-HSA-9609690;Reactome: R-HSA-6811436;Reactome: R-HSA-2467813;Reactome: R-HSA-9646399	"RHO GTPases Activate Formins";"Resolution of Sister Chromatid Cohesion";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-mediated anterograde transport";"MHC class II antigen presentation";"EML4 and NUDC in mitotic spindle formation";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Mitotic Prometaphase";"HCMV Early Events";"COPI-independent Golgi-to-ER retrograde traffic";"Separation of Sister Chromatids";"Aggrephagy"
XP_046418444.1	1	Reactome: R-HSA-3238698	"WNT ligand biogenesis and trafficking"
XP_046435858.1	2	Reactome: R-HSA-6804115;Reactome: R-HSA-429947	"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Deadenylation of mRNA"
XP_046433025.1	10	Reactome: R-HSA-210744;Reactome: R-HSA-1912408;Reactome: R-HSA-9013695;Reactome: R-HSA-8941856;Reactome: R-HSA-2894862;Reactome: R-HSA-2197563;Reactome: R-HSA-350054;Reactome: R-HSA-9013508;Reactome: R-HSA-2644606;Reactome: R-HSA-2122947	"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells";"Pre-NOTCH Transcription and Translation";"NOTCH4 Intracellular Domain Regulates Transcription";"RUNX3 regulates NOTCH signaling";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"NOTCH2 intracellular domain regulates transcription";"Notch-HLH transcription pathway";"NOTCH3 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH1 Intracellular Domain Regulates Transcription"
XP_046432746.1	5	Reactome: R-HSA-109704;Reactome: R-HSA-2219530;Reactome: R-HSA-5673001;Reactome: R-HSA-6811558;Reactome: R-HSA-1257604	"PI3K Cascade";"Constitutive Signaling by Aberrant PI3K in Cancer";"RAF/MAP kinase cascade";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"PIP3 activates AKT signaling"
XP_046434837.1	1	Reactome: R-HSA-2132295	"MHC class II antigen presentation"
XP_046435893.1	3	Reactome: R-HSA-445095;Reactome: R-HSA-8963901;Reactome: R-HSA-6807878	"Interaction between L1 and Ankyrins";"Chylomicron remodeling";"COPI-mediated anterograde transport"
XP_046409882.1	2	Reactome: R-HSA-72163;Reactome: R-HSA-430039	"mRNA Splicing - Major Pathway";"mRNA decay by 5' to 3' exoribonuclease"
XP_046413597.1	5	Reactome: R-HSA-111447;Reactome: R-HSA-5628897;Reactome: R-HSA-1445148;Reactome: R-HSA-75035;Reactome: R-HSA-5625740	"Activation of BAD and translocation to mitochondria";"TP53 Regulates Metabolic Genes";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex";"RHO GTPases activate PKNs"
XP_046418719.1	3	Reactome: R-HSA-4420097;KEGG: 04660+2.7.10.2;Reactome: R-HSA-391160	"VEGFA-VEGFR2 Pathway";"T cell receptor signaling pathway";"Signal regulatory protein family interactions"
XP_046420285.1	15	Reactome: R-HSA-5467333;Reactome: R-HSA-5358751;Reactome: R-HSA-5358752;Reactome: R-HSA-195253;Reactome: R-HSA-3769402;Reactome: R-HSA-111465;Reactome: R-HSA-5358747;Reactome: R-HSA-5339716;Reactome: R-HSA-4641262;Reactome: R-HSA-5467340;Reactome: R-HSA-196299;Reactome: R-HSA-5358749;Reactome: R-HSA-5689896;Reactome: R-HSA-5467348;Reactome: R-HSA-5467337	"APC truncation mutants are not K63 polyubiquitinated";"S45 mutants of beta-catenin aren't phosphorylated";"T41 mutants of beta-catenin aren't phosphorylated";"Degradation of beta-catenin by the destruction complex";"Deactivation of the beta-catenin transactivating complex";"Apoptotic cleavage of cellular proteins";"S33 mutants of beta-catenin aren't phosphorylated";"Misspliced GSK3beta mutants stabilize beta-catenin";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"AXIN missense mutants destabilize the destruction complex";"Beta-catenin phosphorylation cascade";"S37 mutants of beta-catenin aren't phosphorylated";"Ovarian tumor domain proteases";"Truncations of AMER1 destabilize the destruction complex";"APC truncation mutants have impaired AXIN binding"
XP_046417141.1	2	Reactome: R-HSA-70350;Reactome: R-HSA-168928	"Fructose catabolism";"DDX58/IFIH1-mediated induction of interferon-alpha/beta"
XP_046433993.1	14	MetaCyc: PWY-7035;MetaCyc: PWY-8041;MetaCyc: PWY-6598;MetaCyc: PWY-7036;MetaCyc: PWY-7602;MetaCyc: PWY-5080;MetaCyc: PWY-7601;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7619;MetaCyc: PWY-7725;MetaCyc: PWY-7724;MetaCyc: PWY-5972;Reactome: R-HSA-75876;MetaCyc: PWY-6433	"(9Z)-tricosene biosynthesis";"Ultra-long-chain fatty acid biosynthesis";"Sciadonate biosynthesis";"Very long chain fatty acid biosynthesis II";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Very long chain fatty acid biosynthesis I";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Fatty acid elongation";"Juniperonate biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Stearate biosynthesis I (animals)";"Synthesis of very long-chain fatty acyl-CoAs";"Hydroxylated fatty acid biosynthesis (plants)"
XP_046412135.1	1	Reactome: R-HSA-8963889	"Assembly of active LPL and LIPC lipase complexes"
XP_046410494.1	8	Reactome: R-HSA-69091;Reactome: R-HSA-68952;Reactome: R-HSA-113501;Reactome: R-HSA-174430;Reactome: R-HSA-69166;Reactome: R-HSA-174411;Reactome: R-HSA-68962;Reactome: R-HSA-69183	"Polymerase switching";"DNA replication initiation";"Inhibition of replication initiation of damaged DNA by RB1/E2F1";"Telomere C-strand synthesis initiation";"Removal of the Flap Intermediate";"Polymerase switching on the C-strand of the telomere";"Activation of the pre-replicative complex";"Processive synthesis on the lagging strand"
XP_046425396.1	2	Reactome: R-HSA-917729;Reactome: R-HSA-162588	"Endosomal Sorting Complex Required For Transport (ESCRT)";"Budding and maturation of HIV virion"
XP_046414986.1	1	Reactome: R-HSA-6794361	"Neurexins and neuroligins"
XP_046410805.1	2	Reactome: R-HSA-1483166;Reactome: R-HSA-1483148	"Synthesis of PA";"Synthesis of PG"
XP_046430055.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046410955.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_046429440.1	1	Reactome: R-HSA-1632852	"Macroautophagy"
XP_046418163.1	1	Reactome: R-HSA-975957	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
XP_046417730.1	5	Reactome: R-HSA-3214815;Reactome: R-HSA-350054;Reactome: R-HSA-2644606;Reactome: R-HSA-2122947;Reactome: R-HSA-2894862	"HDACs deacetylate histones";"Notch-HLH transcription pathway";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH1 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants"
XP_046414975.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046434474.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046415754.1	7	KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1	"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Relaxin signaling pathway";"Thermogenesis";"Human cytomegalovirus infection";"mTOR signaling pathway";"PI3K-Akt signaling pathway"
XP_046434716.1	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
XP_046434390.1	2	Reactome: R-HSA-2514853;Reactome: R-HSA-2299718	"Condensation of Prometaphase Chromosomes";"Condensation of Prophase Chromosomes"
XP_046410834.1	6	Reactome: R-HSA-2892245;Reactome: R-HSA-2892247;Reactome: R-HSA-8986944;Reactome: R-HSA-6785807;Reactome: R-HSA-452723;Reactome: R-HSA-3769402	"POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation";"POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation";"Transcriptional Regulation by MECP2";"Interleukin-4 and Interleukin-13 signaling";"Transcriptional regulation of pluripotent stem cells";"Deactivation of the beta-catenin transactivating complex"
XP_046421972.1	2	Reactome: R-HSA-418457;Reactome: R-HSA-1296052	"cGMP effects";"Ca2+ activated K+ channels"
XP_046429513.1	1	Reactome: R-HSA-419771	"Opsins"
XP_046417765.1	3	Reactome: R-HSA-9603798;Reactome: R-HSA-9033241;Reactome: R-HSA-8866654	"Class I peroxisomal membrane protein import";"Peroxisomal protein import";"E3 ubiquitin ligases ubiquitinate target proteins"
XP_046434991.1	1	Reactome: R-HSA-426048	"Arachidonate production from DAG"
XP_046418348.1	3	Reactome: R-HSA-416482;Reactome: R-HSA-194840;Reactome: R-HSA-193648	"G alpha (12/13) signalling events";"Rho GTPase cycle";"NRAGE signals death through JNK"
XP_046414625.1	4	Reactome: R-HSA-2644606;Reactome: R-HSA-2894862;Reactome: R-HSA-2122947;Reactome: R-HSA-350054	"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"NOTCH1 Intracellular Domain Regulates Transcription";"Notch-HLH transcription pathway"
XP_046435438.1	2	Reactome: R-HSA-8873719;Reactome: R-HSA-6803205	"RAB geranylgeranylation";"TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain"
XP_046428667.1	1	Reactome: R-HSA-427413	"NoRC negatively regulates rRNA expression"
XP_046436186.1	17	Reactome: R-HSA-2871837;Reactome: R-HSA-9014325;Reactome: R-HSA-1169091;Reactome: R-HSA-937072;Reactome: R-HSA-975163;Reactome: R-HSA-450302;Reactome: R-HSA-5607764;Reactome: R-HSA-4086398;Reactome: R-HSA-445989;Reactome: R-HSA-5357956;Reactome: R-HSA-202424;Reactome: R-HSA-168638;Reactome: R-HSA-937042;Reactome: R-HSA-450321;Reactome: R-HSA-9645460;Reactome: R-HSA-9020702;Reactome: R-HSA-5689880	"FCERI mediated NF-kB activation";"TICAM1,TRAF6-dependent induction of TAK1 complex";"Activation of NF-kappaB in B cells";"TRAF6-mediated induction of TAK1 complex within TLR4 complex";"IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation";"activated TAK1 mediates p38 MAPK activation";"CLEC7A (Dectin-1) signaling";"Ca2+ pathway";"TAK1 activates NFkB by phosphorylation and activation of IKKs complex";"TNFR1-induced NFkappaB signaling pathway";"Downstream TCR signaling";"NOD1/2 Signaling Pathway";"IRAK2 mediated activation of TAK1 complex";"JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1";"Alpha-protein kinase 1 signaling pathway";"Interleukin-1 signaling";"Ub-specific processing proteases"
XP_046415729.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046430412.1	27	Reactome: R-HSA-4570464;Reactome: R-HSA-9610379;Reactome: R-HSA-159236;Reactome: R-HSA-9609690;Reactome: R-HSA-3108214;Reactome: R-HSA-159231;Reactome: R-HSA-1169408;Reactome: R-HSA-168325;Reactome: R-HSA-170822;Reactome: R-HSA-3232142;Reactome: R-HSA-180910;Reactome: R-HSA-3371453;Reactome: R-HSA-4551638;Reactome: R-HSA-165054;Reactome: R-HSA-6784531;Reactome: R-HSA-4085377;Reactome: R-HSA-168276;Reactome: R-HSA-5619107;Reactome: R-HSA-3301854;Reactome: R-HSA-180746;Reactome: R-HSA-159230;Reactome: R-HSA-5578749;Reactome: R-HSA-191859;Reactome: R-HSA-4615885;Reactome: R-HSA-168271;Reactome: R-HSA-168333;Reactome: R-HSA-159227	"SUMOylation of RNA binding proteins";"HCMV Late Events";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"HCMV Early Events";"SUMOylation of DNA damage response and repair proteins";"Transport of Mature mRNA Derived from an Intronless Transcript";"ISG15 antiviral mechanism";"Viral Messenger RNA Synthesis";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"SUMOylation of ubiquitinylation proteins";"Vpr-mediated nuclear import of PICs";"Regulation of HSF1-mediated heat shock response";"SUMOylation of chromatin organization proteins";"Rev-mediated nuclear export of HIV RNA";"tRNA processing in the nucleus";"SUMOylation of SUMOylation proteins";"NS1 Mediated Effects on Host Pathways";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Nuclear Pore Complex (NPC) Disassembly";"Nuclear import of Rev protein";"Transport of the SLBP Dependant Mature mRNA";"Transcriptional regulation by small RNAs";"snRNP Assembly";"SUMOylation of DNA replication proteins";"Transport of Ribonucleoproteins into the Host Nucleus";"NEP/NS2 Interacts with the Cellular Export Machinery";"Transport of the SLBP independent Mature mRNA"
XP_046430473.1	4	Reactome: R-HSA-201722;Reactome: R-HSA-2122947;Reactome: R-HSA-4641265;Reactome: R-HSA-3769402	"Formation of the beta-catenin:TCF transactivating complex";"NOTCH1 Intracellular Domain Regulates Transcription";"Repression of WNT target genes";"Deactivation of the beta-catenin transactivating complex"
XP_046435757.1	5	MetaCyc: PWY-3341;Reactome: R-HSA-8964539;MetaCyc: PWY-6344;MetaCyc: PWY-4981;KEGG: 00330+1.5.1.2	"L-proline biosynthesis III (from L-ornithine)";"Glutamate and glutamine metabolism";"L-ornithine degradation II (Stickland reaction)";"L-proline biosynthesis II (from arginine)";"Arginine and proline metabolism"
XP_046435579.1	6	Reactome: R-HSA-70370;MetaCyc: PWY-6317;MetaCyc: PWY-6527;KEGG: 00520+2.7.7.12;Reactome: R-HSA-5609978;KEGG: 00052+2.7.7.12	"Galactose catabolism";"D-galactose degradation I (Leloir pathway)";"Stachyose degradation";"Amino sugar and nucleotide sugar metabolism";"Defective GALT can cause Galactosemia";"Galactose metabolism"
XP_046428167.1	2	Reactome: R-HSA-5689896;Reactome: R-HSA-195253	"Ovarian tumor domain proteases";"Degradation of beta-catenin by the destruction complex"
XP_046421185.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046426733.1	2	Reactome: R-HSA-983168;Reactome: R-HSA-9635465	"Antigen processing: Ubiquitination & Proteasome degradation";"Suppression of apoptosis"
XP_046427919.1	4	Reactome: R-HSA-379726;KEGG: 00860+6.1.1.17;MetaCyc: PWY-5188;KEGG: 00970+6.1.1.17	"Mitochondrial tRNA aminoacylation";"Porphyrin and chlorophyll metabolism";"Tetrapyrrole biosynthesis I (from glutamate)";"Aminoacyl-tRNA biosynthesis"
XP_046419600.1	7	Reactome: R-HSA-1483191;MetaCyc: PWY-3385;Reactome: R-HSA-1483213;MetaCyc: PWY-7886;KEGG: 00564+2.7.1.32+2.7.1.82;MetaCyc: PWY-7782;MetaCyc: PWY-7818	"Synthesis of PC";"Choline biosynthesis I";"Synthesis of PE";"Cell-surface glycoconjugate-linked phosphocholine biosynthesis";"Glycerophospholipid metabolism";"Plasmalogen biosynthesis";"Type IV lipoteichoic acid biosynthesis (S. pneumoniae)"
XP_046417911.1	10	KEGG: 00052+5.1.3.2;Reactome: R-HSA-70370;KEGG: 00520+5.1.3.2;MetaCyc: PWY-6397;Reactome: R-HSA-5609977;MetaCyc: PWY-6317;MetaCyc: PWY-3821;MetaCyc: PWY-6527;MetaCyc: PWY-7344;MetaCyc: PWY-7328	"Galactose metabolism";"Galactose catabolism";"Amino sugar and nucleotide sugar metabolism";"Mycolyl-arabinogalactan-peptidoglycan complex biosynthesis";"Defective GALE can cause Epimerase-deficiency galactosemia (EDG)";"D-galactose degradation I (Leloir pathway)";"D-galactose detoxification";"Stachyose degradation";"UDP-alpha-D-galactose biosynthesis";"Superpathway of UDP-glucose-derived O-antigen building blocks biosynthesis"
XP_046427168.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046431735.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_046427947.1	2	Reactome: R-HSA-2151201;Reactome: R-HSA-1989781	"Transcriptional activation of mitochondrial biogenesis";"PPARA activates gene expression"
XP_046432975.1	1	Reactome: R-HSA-70221	"Glycogen breakdown (glycogenolysis)"
XP_046413842.1	16	Reactome: R-HSA-174084;Reactome: R-HSA-8853884;Reactome: R-HSA-176409;Reactome: R-HSA-174048;Reactome: R-HSA-179409;Reactome: R-HSA-176412;Reactome: R-HSA-983168;Reactome: R-HSA-141430;Reactome: R-HSA-174184;Reactome: R-HSA-176407;Reactome: R-HSA-176408;Reactome: R-HSA-174154;Reactome: R-HSA-69017;Reactome: R-HSA-174178;Reactome: R-HSA-2559582;Reactome: R-HSA-2467813	"Autodegradation of Cdh1 by Cdh1:APC/C";"Transcriptional Regulation by VENTX";"APC/C:Cdc20 mediated degradation of mitotic proteins";"APC/C:Cdc20 mediated degradation of Cyclin B";"APC-Cdc20 mediated degradation of Nek2A";"Phosphorylation of the APC/C";"Antigen processing: Ubiquitination & Proteasome degradation";"Inactivation of APC/C via direct inhibition of the APC/C complex";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"Regulation of APC/C activators between G1/S and early anaphase";"APC/C:Cdc20 mediated degradation of Securin";"CDK-mediated phosphorylation and removal of Cdc6";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Senescence-Associated Secretory Phenotype (SASP)";"Separation of Sister Chromatids"
XP_046425777.1	20	Reactome: R-HSA-69091;Reactome: R-HSA-110314;Reactome: R-HSA-5656121;Reactome: R-HSA-5696397;Reactome: R-HSA-5655862;Reactome: R-HSA-5693616;Reactome: R-HSA-176187;Reactome: R-HSA-5656169;Reactome: R-HSA-69473;Reactome: R-HSA-6804756;Reactome: R-HSA-5693607;Reactome: R-HSA-5685942;Reactome: R-HSA-6782210;Reactome: R-HSA-6782135;Reactome: R-HSA-110320;Reactome: R-HSA-5696400;Reactome: R-HSA-5685938;Reactome: R-HSA-110312;Reactome: R-HSA-174411;Reactome: R-HSA-5651801	"Polymerase switching";"Recognition of DNA damage by PCNA-containing replication complex";"Translesion synthesis by POLI";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Translesion synthesis by POLK";"Presynaptic phase of homologous DNA pairing and strand exchange";"Activation of ATR in response to replication stress";"Termination of translesion DNA synthesis";"G2/M DNA damage checkpoint";"Regulation of TP53 Activity through Phosphorylation";"Processing of DNA double-strand break ends";"HDR through Homologous Recombination (HRR)";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Dual incision in TC-NER";"Translesion Synthesis by POLH";"Dual Incision in GG-NER";"HDR through Single Strand Annealing (SSA)";"Translesion synthesis by REV1";"Polymerase switching on the C-strand of the telomere";"PCNA-Dependent Long Patch Base Excision Repair"
XP_046410095.1	13	Reactome: R-HSA-450302;Reactome: R-HSA-2871837;Reactome: R-HSA-9014325;Reactome: R-HSA-5607764;Reactome: R-HSA-937072;Reactome: R-HSA-5357956;Reactome: R-HSA-445989;Reactome: R-HSA-168638;Reactome: R-HSA-975163;Reactome: R-HSA-450321;Reactome: R-HSA-937042;Reactome: R-HSA-9020702;Reactome: R-HSA-9645460	"activated TAK1 mediates p38 MAPK activation";"FCERI mediated NF-kB activation";"TICAM1,TRAF6-dependent induction of TAK1 complex";"CLEC7A (Dectin-1) signaling";"TRAF6-mediated induction of TAK1 complex within TLR4 complex";"TNFR1-induced NFkappaB signaling pathway";"TAK1 activates NFkB by phosphorylation and activation of IKKs complex";"NOD1/2 Signaling Pathway";"IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation";"JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1";"IRAK2 mediated activation of TAK1 complex";"Interleukin-1 signaling";"Alpha-protein kinase 1 signaling pathway"
XP_046413116.1	3	Reactome: R-HSA-8951664;Reactome: R-HSA-390471;Reactome: R-HSA-983168	"Neddylation";"Association of TriC/CCT with target proteins during biosynthesis";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046418196.1	3	Reactome: R-HSA-264870;Reactome: R-HSA-6798695;Reactome: R-HSA-6794361	"Caspase-mediated cleavage of cytoskeletal proteins";"Neutrophil degranulation";"Neurexins and neuroligins"
XP_046436204.1	10	Reactome: R-HSA-111464;Reactome: R-HSA-111458;Reactome: R-HSA-5628897;Reactome: R-HSA-611105;Reactome: R-HSA-111459;Reactome: R-HSA-9627069;Reactome: R-HSA-111457;Reactome: R-HSA-3299685;Reactome: R-HSA-2151201;Reactome: R-HSA-111463	"SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes";"Formation of apoptosome";"TP53 Regulates Metabolic Genes";"Respiratory electron transport";"Activation of caspases through apoptosome-mediated cleavage";"Regulation of the apoptosome activity";"Release of apoptotic factors from the mitochondria";"Detoxification of Reactive Oxygen Species";"Transcriptional activation of mitochondrial biogenesis";"SMAC (DIABLO) binds to IAPs"
XP_046415225.1	2	Reactome: R-HSA-1989781;Reactome: R-HSA-2151201	"PPARA activates gene expression";"Transcriptional activation of mitochondrial biogenesis"
XP_046413538.1	6	KEGG: 00720+4.2.1.3;KEGG: 00630+4.2.1.3;Reactome: R-HSA-71403;KEGG: 00020+4.2.1.3;KEGG: 00290+4.2.1.33;Reactome: R-HSA-1268020	"Carbon fixation pathways in prokaryotes";"Glyoxylate and dicarboxylate metabolism";"Citric acid cycle (TCA cycle)";"Citrate cycle (TCA cycle)";"Valine, leucine and isoleucine biosynthesis";"Mitochondrial protein import"
XP_046429739.1	16	Reactome: R-HSA-176409;Reactome: R-HSA-8853884;Reactome: R-HSA-174084;Reactome: R-HSA-176412;Reactome: R-HSA-179409;Reactome: R-HSA-174048;Reactome: R-HSA-141430;Reactome: R-HSA-983168;Reactome: R-HSA-2559582;Reactome: R-HSA-174178;Reactome: R-HSA-2467813;Reactome: R-HSA-69017;Reactome: R-HSA-174154;Reactome: R-HSA-174184;Reactome: R-HSA-176407;Reactome: R-HSA-176408	"APC/C:Cdc20 mediated degradation of mitotic proteins";"Transcriptional Regulation by VENTX";"Autodegradation of Cdh1 by Cdh1:APC/C";"Phosphorylation of the APC/C";"APC-Cdc20 mediated degradation of Nek2A";"APC/C:Cdc20 mediated degradation of Cyclin B";"Inactivation of APC/C via direct inhibition of the APC/C complex";"Antigen processing: Ubiquitination & Proteasome degradation";"Senescence-Associated Secretory Phenotype (SASP)";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Separation of Sister Chromatids";"CDK-mediated phosphorylation and removal of Cdc6";"APC/C:Cdc20 mediated degradation of Securin";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"Regulation of APC/C activators between G1/S and early anaphase"
XP_046413812.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046427398.1	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
XP_046433549.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046432336.1	7	Reactome: R-HSA-380270;Reactome: R-HSA-2565942;Reactome: R-HSA-380320;Reactome: R-HSA-380259;Reactome: R-HSA-8854518;Reactome: R-HSA-380284;Reactome: R-HSA-5620912	"Recruitment of mitotic centrosome proteins and complexes";"Regulation of PLK1 Activity at G2/M Transition";"Recruitment of NuMA to mitotic centrosomes";"Loss of Nlp from mitotic centrosomes";"AURKA Activation by TPX2";"Loss of proteins required for interphase microtubule organization from the centrosome";"Anchoring of the basal body to the plasma membrane"
XP_046412933.1	57	Reactome: R-HSA-5687128;Reactome: R-HSA-174113;Reactome: R-HSA-9020702;Reactome: R-HSA-8854050;Reactome: R-HSA-5610783;Reactome: R-HSA-8852276;Reactome: R-HSA-69481;Reactome: R-HSA-1234176;Reactome: R-HSA-8948751;Reactome: R-HSA-187577;Reactome: R-HSA-180534;Reactome: R-HSA-5607764;Reactome: R-HSA-68827;Reactome: R-HSA-5689603;Reactome: R-HSA-9010553;Reactome: R-HSA-8941858;Reactome: R-HSA-350562;Reactome: R-HSA-5668541;Reactome: R-HSA-4641258;Reactome: R-HSA-211733;Reactome: R-HSA-5632684;Reactome: R-HSA-450408;Reactome: R-HSA-5610780;Reactome: R-HSA-1236974;Reactome: R-HSA-195253;Reactome: R-HSA-174178;Reactome: R-HSA-2871837;Reactome: R-HSA-382556;Reactome: R-HSA-68949;Reactome: R-HSA-1169091;Reactome: R-HSA-5362768;Reactome: R-HSA-5676590;Reactome: R-HSA-9604323;Reactome: R-HSA-5358346;Reactome: R-HSA-69601;Reactome: R-HSA-69017;Reactome: R-HSA-202424;Reactome: R-HSA-75815;Reactome: R-HSA-4641257;Reactome: R-HSA-4608870;Reactome: R-HSA-1236978;Reactome: R-HSA-349425;Reactome: R-HSA-8951664;Reactome: R-HSA-5689880;Reactome: R-HSA-174084;Reactome: R-HSA-8939236;Reactome: R-HSA-5610785;Reactome: R-HSA-180585;Reactome: R-HSA-5678895;Reactome: R-HSA-6798695;Reactome: R-HSA-983168;Reactome: R-HSA-5658442;Reactome: R-HSA-5607761;Reactome: R-HSA-2467813;Reactome: R-HSA-8939902;Reactome: R-HSA-174184;Reactome: R-HSA-174154	"MAPK6/MAPK4 signaling";"SCF-beta-TrCP mediated degradation of Emi1";"Interleukin-1 signaling";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"Degradation of GLI2 by the proteasome";"The role of GTSE1 in G2/M progression after G2 checkpoint";"G2/M Checkpoints";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of PTEN stability and activity";"SCF(Skp2)-mediated degradation of p27/p21";"Vpu mediated degradation of CD4";"CLEC7A (Dectin-1) signaling";"CDT1 association with the CDC6:ORC:origin complex";"UCH proteinases";"Regulation of expression of SLITs and ROBOs";"Regulation of RUNX3 expression and activity";"Regulation of ornithine decarboxylase (ODC)";"TNFR2 non-canonical NF-kB pathway";"Degradation of DVL";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"Hedgehog 'on' state";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Degradation of GLI1 by the proteasome";"ER-Phagosome pathway";"Degradation of beta-catenin by the destruction complex";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"FCERI mediated NF-kB activation";"ABC-family proteins mediated transport";"Orc1 removal from chromatin";"Activation of NF-kappaB in B cells";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"NIK-->noncanonical NF-kB signaling";"Negative regulation of NOTCH4 signaling";"Hedgehog ligand biogenesis";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"CDK-mediated phosphorylation and removal of Cdc6";"Downstream TCR signaling";"Ubiquitin-dependent degradation of Cyclin D";"Degradation of AXIN";"Asymmetric localization of PCP proteins";"Cross-presentation of soluble exogenous antigens (endosomes)";"Autodegradation of the E3 ubiquitin ligase COP1";"Neddylation";"Ub-specific processing proteases";"Autodegradation of Cdh1 by Cdh1:APC/C";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"GLI3 is processed to GLI3R by the proteasome";"Vif-mediated degradation of APOBEC3G";"Defective CFTR causes cystic fibrosis";"Neutrophil degranulation";"Antigen processing: Ubiquitination & Proteasome degradation";"Regulation of RAS by GAPs";"Dectin-1 mediated noncanonical NF-kB signaling";"Separation of Sister Chromatids";"Regulation of RUNX2 expression and activity";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"APC/C:Cdc20 mediated degradation of Securin"
XP_046425875.1	3	Reactome: R-HSA-5578775;Reactome: R-HSA-936837;Reactome: R-HSA-418359	"Ion homeostasis";"Ion transport by P-type ATPases";"Reduction of cytosolic Ca++ levels"
XP_046434082.1	1	Reactome: R-HSA-5662702	"Melanin biosynthesis"
XP_046430119.1	1	Reactome: R-HSA-8876725	"Protein methylation"
XP_046436320.1	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
XP_046429516.1	1	Reactome: R-HSA-419771	"Opsins"
XP_046434303.1	7	Reactome: R-HSA-73980;Reactome: R-HSA-73780;Reactome: R-HSA-76071;Reactome: R-HSA-1834949;Reactome: R-HSA-749476;Reactome: R-HSA-76061;Reactome: R-HSA-76066	"RNA Polymerase III Transcription Termination";"RNA Polymerase III Chain Elongation";"RNA Polymerase III Transcription Initiation From Type 3 Promoter";"Cytosolic sensors of pathogen-associated DNA";"RNA Polymerase III Abortive And Retractive Initiation";"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Transcription Initiation From Type 2 Promoter"
XP_046431679.1	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
XP_046431649.1	13	KEGG: 00604+3.2.1.52;KEGG: 00511+3.2.1.52;KEGG: 00603+3.2.1.52;Reactome: R-HSA-1660662;MetaCyc: PWY-7883;Reactome: R-HSA-2022857;KEGG: 00520+3.2.1.52;Reactome: R-HSA-2024101;MetaCyc: PWY-6902;MetaCyc: PWY-7822;KEGG: 00513+3.2.1.52;Reactome: R-HSA-2160916;KEGG: 00531+3.2.1.52	"Glycosphingolipid biosynthesis - ganglio series";"Other glycan degradation";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Glycosphingolipid metabolism";"Anhydromuropeptides recycling II";"Keratan sulfate degradation";"Amino sugar and nucleotide sugar metabolism";"CS/DS degradation";"Chitin degradation II (Vibrio)";"Chitin degradation III (Serratia)";"Various types of N-glycan biosynthesis";"Hyaluronan uptake and degradation";"Glycosaminoglycan degradation"
XP_046425604.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046426240.1	1	Reactome: R-HSA-1474228	"Degradation of the extracellular matrix"
XP_046428787.1	1	Reactome: R-HSA-977225	"Amyloid fiber formation"
XP_046418482.1	1	Reactome: R-HSA-8854214	"TBC/RABGAPs"
XP_046412476.1	1	KEGG: 00970+6.3.5.7	"Aminoacyl-tRNA biosynthesis"
XP_046411976.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_046410042.1	1	Reactome: R-HSA-196108	"Pregnenolone biosynthesis"
XP_046426898.1	2	Reactome: R-HSA-1268020;Reactome: R-HSA-1482798	"Mitochondrial protein import";"Acyl chain remodeling of CL"
XP_046418197.1	3	Reactome: R-HSA-6794361;Reactome: R-HSA-264870;Reactome: R-HSA-6798695	"Neurexins and neuroligins";"Caspase-mediated cleavage of cytoskeletal proteins";"Neutrophil degranulation"
XP_046425884.1	1	Reactome: R-HSA-1971475	"A tetrasaccharide linker sequence is required for GAG synthesis"
XP_046429484.1	1	Reactome: R-HSA-419771	"Opsins"
XP_046423865.1	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_046415009.1	7	KEGG: 00250+3.5.1.2;MetaCyc: PWY-5921;Reactome: R-HSA-210500;Reactome: R-HSA-5628897;KEGG: 00471+3.5.1.2;Reactome: R-HSA-8964539;KEGG: 00220+3.5.1.2	"Alanine, aspartate and glutamate metabolism";"Glutaminyl-trnagln biosynthesis via transamidation";"Glutamate Neurotransmitter Release Cycle";"TP53 Regulates Metabolic Genes";"D-Glutamine and D-glutamate metabolism";"Glutamate and glutamine metabolism";"Arginine biosynthesis"
XP_046423943.1	14	MetaCyc: PWY-6433;MetaCyc: PWY-7724;Reactome: R-HSA-75876;MetaCyc: PWY-5972;MetaCyc: PWY-7619;MetaCyc: PWY-7725;MetaCyc: PWY-5080;MetaCyc: PWY-7601;KEGG: 00062+2.3.1.199;MetaCyc: PWY-8041;MetaCyc: PWY-6598;MetaCyc: PWY-7036;MetaCyc: PWY-7602;MetaCyc: PWY-7035	"Hydroxylated fatty acid biosynthesis (plants)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Synthesis of very long-chain fatty acyl-CoAs";"Stearate biosynthesis I (animals)";"Juniperonate biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Very long chain fatty acid biosynthesis I";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Fatty acid elongation";"Ultra-long-chain fatty acid biosynthesis";"Sciadonate biosynthesis";"Very long chain fatty acid biosynthesis II";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"(9Z)-tricosene biosynthesis"
XP_046413627.1	2	Reactome: R-HSA-2029482;Reactome: R-HSA-5663213	"Regulation of actin dynamics for phagocytic cup formation";"RHO GTPases Activate WASPs and WAVEs"
XP_046411903.1	1	Reactome: R-HSA-5221030	"TET1,2,3 and TDG demethylate DNA"
XP_046427067.1	3	Reactome: R-HSA-977347;KEGG: 00680+3.1.3.3;KEGG: 00260+3.1.3.3	"Serine biosynthesis";"Methane metabolism";"Glycine, serine and threonine metabolism"
XP_046423695.1	4	Reactome: R-HSA-4720489;Reactome: R-HSA-446193;KEGG: 00513+2.4.1.260;KEGG: 00510+2.4.1.260	"Defective ALG12 causes ALG12-CDG (CDG-1g)";"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"Various types of N-glycan biosynthesis";"N-Glycan biosynthesis"
XP_046429229.1	1	Reactome: R-HSA-420499	"Class C/3 (Metabotropic glutamate/pheromone receptors)"
XP_046410548.1	8	Reactome: R-HSA-68962;Reactome: R-HSA-174411;Reactome: R-HSA-69183;Reactome: R-HSA-69166;Reactome: R-HSA-174430;Reactome: R-HSA-113501;Reactome: R-HSA-68952;Reactome: R-HSA-69091	"Activation of the pre-replicative complex";"Polymerase switching on the C-strand of the telomere";"Processive synthesis on the lagging strand";"Removal of the Flap Intermediate";"Telomere C-strand synthesis initiation";"Inhibition of replication initiation of damaged DNA by RB1/E2F1";"DNA replication initiation";"Polymerase switching"
XP_046423671.1	1	Reactome: R-HSA-446210	"Synthesis of UDP-N-acetyl-glucosamine"
XP_046424432.1	1	Reactome: R-HSA-2467813	"Separation of Sister Chromatids"
XP_046429155.1	6	MetaCyc: PWY-7765;Reactome: R-HSA-71240;KEGG: 00380+1.14.13.9;MetaCyc: PWY-6309;MetaCyc: PWY-5651;MetaCyc: PWY-7717	"3-hydroxy-4-methyl-anthranilate biosynthesis II";"Tryptophan catabolism";"Tryptophan metabolism";"L-tryptophan degradation XI (mammalian, via kynurenine)";"L-tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde";"3-hydroxy-4-methyl-anthranilate biosynthesis I"
XP_046428189.1	1	Reactome: R-HSA-2564830	"Cytosolic iron-sulfur cluster assembly"
XP_046416873.1	1	Reactome: R-HSA-3214858	"RMTs methylate histone arginines"
XP_046428438.1	7	KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1	"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Relaxin signaling pathway";"Thermogenesis";"Human cytomegalovirus infection";"mTOR signaling pathway";"PI3K-Akt signaling pathway"
XP_046424512.1	1	Reactome: R-HSA-1445148	"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
XP_046425089.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_046435916.1	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
XP_046414123.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_046413787.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046434191.1	1	Reactome: R-HSA-1474228	"Degradation of the extracellular matrix"
XP_046414770.1	8	Reactome: R-HSA-6804757;Reactome: R-HSA-6781823;Reactome: R-HSA-5689880;Reactome: R-HSA-6782210;Reactome: R-HSA-6782135;Reactome: R-HSA-6781827;Reactome: R-HSA-8948747;Reactome: R-HSA-8866652	"Regulation of TP53 Degradation";"Formation of TC-NER Pre-Incision Complex";"Ub-specific processing proteases";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Dual incision in TC-NER";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)";"Regulation of PTEN localization";"Synthesis of active ubiquitin: roles of E1 and E2 enzymes"
XP_046417696.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-6798695	"Protein ubiquitination";"Neutrophil degranulation"
XP_046417208.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046427350.1	1	Reactome: R-HSA-8951664	"Neddylation"
XP_046412932.1	1	Reactome: R-HSA-1483166	"Synthesis of PA"
XP_046430925.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_046414024.1	1	Reactome: R-HSA-419771	"Opsins"
XP_046431498.1	4	Reactome: R-HSA-3371568;Reactome: R-HSA-9018519;Reactome: R-HSA-3371497;Reactome: R-HSA-8939211	"Attenuation phase";"Estrogen-dependent gene expression";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"ESR-mediated signaling"
XP_046432293.1	4	KEGG: 00230+4.1.1.97;MetaCyc: PWY-7394;MetaCyc: PWY-7849;MetaCyc: PWY-5691	"Purine metabolism";"Urate conversion to allantoin II";"Urate conversion to allantoin III";"Urate conversion to allantoin I"
XP_046430290.1	5	Reactome: R-HSA-73856;Reactome: R-HSA-77595;Reactome: R-HSA-168315;Reactome: R-HSA-72163;Reactome: R-HSA-72187	"RNA Polymerase II Transcription Termination";"Processing of Intronless Pre-mRNAs";"Inhibition of Host mRNA Processing and RNA Silencing";"mRNA Splicing - Major Pathway";"mRNA 3'-end processing"
XP_046414362.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046423289.1	2	Reactome: R-HSA-1268020;Reactome: R-HSA-8949613	"Mitochondrial protein import";"Cristae formation"
XP_046425139.1	1	Reactome: R-HSA-418990	"Adherens junctions interactions"
XP_046421920.1	12	KEGG: 00564+3.1.1.4;MetaCyc: PWY-7417;KEGG: 00591+3.1.1.4;MetaCyc: PWY-8053;MetaCyc: PWY-7416;MetaCyc: PWY-7409;KEGG: 00592+3.1.1.4;MetaCyc: PWY-7783;KEGG: 00590+3.1.1.4;KEGG: 00565+3.1.1.4;MetaCyc: PWY-6803;MetaCyc: PWY-8051	"Glycerophospholipid metabolism";"Phospholipid remodeling (phosphatidate, yeast)";"Linoleic acid metabolism";"Anandamide biosynthesis II";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"alpha-Linolenic acid metabolism";"Plasmalogen degradation";"Arachidonic acid metabolism";"Ether lipid metabolism";"Phosphatidylcholine acyl editing";"Anandamide biosynthesis I"
XP_046426241.1	1	Reactome: R-HSA-1474228	"Degradation of the extracellular matrix"
XP_046434296.1	6	Reactome: R-HSA-6798695;Reactome: R-HSA-2453902;Reactome: R-HSA-977225;Reactome: R-HSA-2453864;Reactome: R-HSA-3000171;Reactome: R-HSA-975634	"Neutrophil degranulation";"The canonical retinoid cycle in rods (twilight vision)";"Amyloid fiber formation";"Retinoid cycle disease events";"Non-integrin membrane-ECM interactions";"Retinoid metabolism and transport"
XP_046436332.1	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
XP_046418436.1	1	Reactome: R-HSA-3238698	"WNT ligand biogenesis and trafficking"
XP_046419319.1	6	Reactome: R-HSA-389957;Reactome: R-HSA-389960;Reactome: R-HSA-5620922;Reactome: R-HSA-390471;Reactome: R-HSA-390450;Reactome: R-HSA-6814122	"Prefoldin mediated transfer of substrate to CCT/TriC";"Formation of tubulin folding intermediates by CCT/TriC";"BBSome-mediated cargo-targeting to cilium";"Association of TriC/CCT with target proteins during biosynthesis";"Folding of actin by CCT/TriC";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"
XP_046421670.1	2	Reactome: R-HSA-72165;Reactome: R-HSA-72163	"mRNA Splicing - Minor Pathway";"mRNA Splicing - Major Pathway"
XP_046415614.1	14	MetaCyc: PWY-5981;MetaCyc: PWY-8053;MetaCyc: PWY-7782;MetaCyc: PWY-7589;MetaCyc: PWY-7417;MetaCyc: PWY-5667;MetaCyc: PWY-8051;KEGG: 00564+2.3.1.51;MetaCyc: PWY-6453;MetaCyc: PWY-8055;KEGG: 00561+2.3.1.51;MetaCyc: PWY-7587;Reactome: R-HSA-1483166;MetaCyc: PWY-7411	"CDP-diacylglycerol biosynthesis III";"Anandamide biosynthesis II";"Plasmalogen biosynthesis";"Palmitoleate biosynthesis III (cyanobacteria)";"Phospholipid remodeling (phosphatidate, yeast)";"CDP-diacylglycerol biosynthesis I";"Anandamide biosynthesis I";"Glycerophospholipid metabolism";"Stigma estolide biosynthesis";"Palmitoyl ethanolamide biosynthesis";"Glycerolipid metabolism";"Oleate biosynthesis III (cyanobacteria)";"Synthesis of PA";"Phosphatidate biosynthesis (yeast)"
XP_046412412.1	3	MetaCyc: PWY-7807;KEGG: 00190+3.6.1.1;MetaCyc: PWY-7805	"Glyphosate degradation III";"Oxidative phosphorylation";"(aminomethyl)phosphonate degradation"
XP_046433562.1	3	Reactome: R-HSA-1358803;Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Downregulation of ERBB2:ERBB3 signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_046429769.1	3	Reactome: R-HSA-159230;Reactome: R-HSA-73856;Reactome: R-HSA-77588	"Transport of the SLBP Dependant Mature mRNA";"RNA Polymerase II Transcription Termination";"SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs"
XP_046426807.1	3	Reactome: R-HSA-6783310;Reactome: R-HSA-110314;Reactome: R-HSA-5689880	"Fanconi Anemia Pathway";"Recognition of DNA damage by PCNA-containing replication complex";"Ub-specific processing proteases"
XP_046426741.1	3	Reactome: R-HSA-349425;MetaCyc: PWY-7511;Reactome: R-HSA-8951664	"Autodegradation of the E3 ubiquitin ligase COP1";"Protein ubiquitination";"Neddylation"
XP_046424486.1	6	MetaCyc: PWY-7656;KEGG: 00073+1.2.1.84;MetaCyc: PWY-6733;Reactome: R-HSA-9640463;MetaCyc: PWY-5884;MetaCyc: PWY-7782	"Spodoptera littoralis pheromone biosynthesis";"Cutin, suberine and wax biosynthesis";"Sporopollenin precursors biosynthesis";"Wax biosynthesis";"Wax esters biosynthesis I";"Plasmalogen biosynthesis"
XP_046435302.1	3	MetaCyc: PWY-6348;KEGG: 00740+3.1.3.2;KEGG: 00730+3.1.3.2	"Phosphate acquisition";"Riboflavin metabolism";"Thiamine metabolism"
XP_046428339.1	2	Reactome: R-HSA-4641265;Reactome: R-HSA-5339700	"Repression of WNT target genes";"TCF7L2 mutants don't bind CTBP"
XP_046420889.1	22	MetaCyc: PWY-8041;MetaCyc: PWY-7035;MetaCyc: PWY-7619;MetaCyc: PWY-7725;MetaCyc: PWY-5080;MetaCyc: PWY-7049;MetaCyc: PWY-7727;MetaCyc: PWY-6433;KEGG: 00062+4.2.1.134;MetaCyc: PWY-7602;MetaCyc: PWY-6598;MetaCyc: PWY-7036;MetaCyc: PWY-6958;MetaCyc: PWY-5353;MetaCyc: PWY-7053;MetaCyc: PWY-7601;MetaCyc: PWY-7724;Reactome: R-HSA-75876;MetaCyc: PWY-7726;MetaCyc: PWY-7592;MetaCyc: PWY-7606;MetaCyc: PWY-7728	"Ultra-long-chain fatty acid biosynthesis";"(9Z)-tricosene biosynthesis";"Juniperonate biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Very long chain fatty acid biosynthesis I";"Icosapentaenoate biosynthesis II (6-desaturase, mammals)";"Docosahexaenoate biosynthesis IV (4-desaturase, mammals)";"Hydroxylated fatty acid biosynthesis (plants)";"Fatty acid elongation";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Sciadonate biosynthesis";"Very long chain fatty acid biosynthesis II";"Icosapentaenoate biosynthesis I (lower eukaryotes)";"Arachidonate biosynthesis I (6-desaturase, lower eukaryotes)";"Docosahexaenoate biosynthesis I (lower eukaryotes)";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Synthesis of very long-chain fatty acyl-CoAs";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)";"Arachidonate biosynthesis III (6-desaturase, mammals)";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)"
XP_046412562.1	4	Reactome: R-HSA-5655862;Reactome: R-HSA-110312;Reactome: R-HSA-5656169;Reactome: R-HSA-5656121	"Translesion synthesis by POLK";"Translesion synthesis by REV1";"Termination of translesion DNA synthesis";"Translesion synthesis by POLI"
XP_046417595.1	2	Reactome: R-HSA-2151201;KEGG: 00970+6.1.1.14	"Transcriptional activation of mitochondrial biogenesis";"Aminoacyl-tRNA biosynthesis"
XP_046431014.1	4	KEGG: 04658+3.1.3.16;Reactome: R-HSA-180024;KEGG: 04660+3.1.3.16;KEGG: 05235+3.1.3.16	"Th1 and Th2 cell differentiation";"DARPP-32 events";"T cell receptor signaling pathway";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
XP_046415938.1	1	Reactome: R-HSA-5620912	"Anchoring of the basal body to the plasma membrane"
XP_046421798.1	2	Reactome: R-HSA-5689603;Reactome: R-HSA-5696394	"UCH proteinases";"DNA Damage Recognition in GG-NER"
XP_046417019.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046426720.1	3	Reactome: R-HSA-196741;KEGG: 00860+2.5.1.17;Reactome: R-HSA-3359471	"Cobalamin (Cbl, vitamin B12) transport and metabolism";"Porphyrin and chlorophyll metabolism";"Defective MMAB causes methylmalonic aciduria type cblB"
XP_046416509.1	2	MetaCyc: PWY-7799;MetaCyc: PWY-7800	"Arg/N-end rule pathway (eukaryotic)";"Ac/N-end rule pathway"
XP_046418267.1	7	Reactome: R-HSA-141444;Reactome: R-HSA-5626467;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813;Reactome: R-HSA-68877;Reactome: R-HSA-2500257;Reactome: R-HSA-5663220	"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"RHO GTPases activate IQGAPs";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids";"Mitotic Prometaphase";"Resolution of Sister Chromatid Cohesion";"RHO GTPases Activate Formins"
XP_046430159.1	12	KEGG: 00130+2.5.1.39;MetaCyc: PWY-5870;MetaCyc: PWY-5856;MetaCyc: PWY-5857;MetaCyc: PWY-5855;MetaCyc: PWY-6708;MetaCyc: PWY-5871;MetaCyc: PWY-6978;MetaCyc: PWY-5873;Reactome: R-HSA-2142789;MetaCyc: PWY-5872;Reactome: R-HSA-1268020	"Ubiquinone and other terpenoid-quinone biosynthesis";"Ubiquinol-8 biosynthesis (eukaryotic)";"Ubiquinol-9 biosynthesis (prokaryotic)";"Ubiquinol-10 biosynthesis (prokaryotic)";"Ubiquinol-7 biosynthesis (prokaryotic)";"Ubiquinol-8 biosynthesis (prokaryotic)";"Ubiquinol-9 biosynthesis (eukaryotic)";"Plastoquinol-9 biosynthesis II";"Ubiquinol-7 biosynthesis (eukaryotic)";"Ubiquinol biosynthesis";"Ubiquinol-10 biosynthesis (eukaryotic)";"Mitochondrial protein import"
XP_046425093.1	7	Reactome: R-HSA-69205;Reactome: R-HSA-1362277;Reactome: R-HSA-69231;Reactome: R-HSA-1538133;Reactome: R-HSA-6804114;Reactome: R-HSA-1362300;Reactome: R-HSA-2173796	"G1/S-Specific Transcription";"Transcription of E2F targets under negative control by DREAM complex";"Cyclin D associated events in G1";"G0 and Early G1";"TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest";"Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1";"SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription"
XP_046421547.1	2	Reactome: R-HSA-8949613;Reactome: R-HSA-163210	"Cristae formation";"Formation of ATP by chemiosmotic coupling"
XP_046418111.1	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
XP_046417378.1	2	Reactome: R-HSA-611105;Reactome: R-HSA-6799198	"Respiratory electron transport";"Complex I biogenesis"
XP_046409678.1	5	Reactome: R-HSA-983712;Reactome: R-HSA-1222556;Reactome: R-HSA-77387;Reactome: R-HSA-917977;Reactome: R-HSA-9639288	"Ion channel transport";"ROS and RNS production in phagocytes";"Insulin receptor recycling";"Transferrin endocytosis and recycling";"Amino acids regulate mTORC1"
XP_046413757.1	27	Reactome: R-HSA-9609690;Reactome: R-HSA-1169408;Reactome: R-HSA-3108214;Reactome: R-HSA-168325;Reactome: R-HSA-159231;Reactome: R-HSA-159236;Reactome: R-HSA-4570464;Reactome: R-HSA-9610379;Reactome: R-HSA-4551638;Reactome: R-HSA-4085377;Reactome: R-HSA-6784531;Reactome: R-HSA-165054;Reactome: R-HSA-3371453;Reactome: R-HSA-180910;Reactome: R-HSA-170822;Reactome: R-HSA-3232142;Reactome: R-HSA-4615885;Reactome: R-HSA-5578749;Reactome: R-HSA-180746;Reactome: R-HSA-159230;Reactome: R-HSA-191859;Reactome: R-HSA-168276;Reactome: R-HSA-3301854;Reactome: R-HSA-5619107;Reactome: R-HSA-159227;Reactome: R-HSA-168333;Reactome: R-HSA-168271	"HCMV Early Events";"ISG15 antiviral mechanism";"SUMOylation of DNA damage response and repair proteins";"Viral Messenger RNA Synthesis";"Transport of Mature mRNA Derived from an Intronless Transcript";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"SUMOylation of RNA binding proteins";"HCMV Late Events";"SUMOylation of chromatin organization proteins";"SUMOylation of SUMOylation proteins";"tRNA processing in the nucleus";"Rev-mediated nuclear export of HIV RNA";"Regulation of HSF1-mediated heat shock response";"Vpr-mediated nuclear import of PICs";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"SUMOylation of ubiquitinylation proteins";"SUMOylation of DNA replication proteins";"Transcriptional regulation by small RNAs";"Nuclear import of Rev protein";"Transport of the SLBP Dependant Mature mRNA";"snRNP Assembly";"NS1 Mediated Effects on Host Pathways";"Nuclear Pore Complex (NPC) Disassembly";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Transport of the SLBP independent Mature mRNA";"NEP/NS2 Interacts with the Cellular Export Machinery";"Transport of Ribonucleoproteins into the Host Nucleus"
XP_046430828.1	1	Reactome: R-HSA-203927	"MicroRNA (miRNA) biogenesis"
XP_046433251.1	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046429522.1	2	Reactome: R-HSA-8876198;Reactome: R-HSA-5357905	"RAB GEFs exchange GTP for GDP on RABs";"Regulation of TNFR1 signaling"
XP_046416506.1	2	KEGG: 00670+2.1.2.10;KEGG: 00260+2.1.2.10	"One carbon pool by folate";"Glycine, serine and threonine metabolism"
XP_046424587.1	7	Reactome: R-HSA-165181;Reactome: R-HSA-8854214;Reactome: R-HSA-380972;Reactome: R-HSA-5674400;Reactome: R-HSA-5628897;Reactome: R-HSA-198323;Reactome: R-HSA-1632852	"Inhibition of TSC complex formation by PKB";"TBC/RABGAPs";"Energy dependent regulation of mTOR by LKB1-AMPK";"Constitutive Signaling by AKT1 E17K in Cancer";"TP53 Regulates Metabolic Genes";"AKT phosphorylates targets in the cytosol";"Macroautophagy"
XP_046425548.1	27	Reactome: R-HSA-3232142;Reactome: R-HSA-170822;Reactome: R-HSA-3371453;Reactome: R-HSA-180910;Reactome: R-HSA-4551638;Reactome: R-HSA-6784531;Reactome: R-HSA-165054;Reactome: R-HSA-4085377;Reactome: R-HSA-4570464;Reactome: R-HSA-9610379;Reactome: R-HSA-159236;Reactome: R-HSA-9609690;Reactome: R-HSA-159231;Reactome: R-HSA-168325;Reactome: R-HSA-3108214;Reactome: R-HSA-1169408;Reactome: R-HSA-168271;Reactome: R-HSA-159227;Reactome: R-HSA-168333;Reactome: R-HSA-168276;Reactome: R-HSA-3301854;Reactome: R-HSA-5619107;Reactome: R-HSA-159230;Reactome: R-HSA-180746;Reactome: R-HSA-5578749;Reactome: R-HSA-191859;Reactome: R-HSA-4615885	"SUMOylation of ubiquitinylation proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Regulation of HSF1-mediated heat shock response";"Vpr-mediated nuclear import of PICs";"SUMOylation of chromatin organization proteins";"tRNA processing in the nucleus";"Rev-mediated nuclear export of HIV RNA";"SUMOylation of SUMOylation proteins";"SUMOylation of RNA binding proteins";"HCMV Late Events";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"HCMV Early Events";"Transport of Mature mRNA Derived from an Intronless Transcript";"Viral Messenger RNA Synthesis";"SUMOylation of DNA damage response and repair proteins";"ISG15 antiviral mechanism";"Transport of Ribonucleoproteins into the Host Nucleus";"Transport of the SLBP independent Mature mRNA";"NEP/NS2 Interacts with the Cellular Export Machinery";"NS1 Mediated Effects on Host Pathways";"Nuclear Pore Complex (NPC) Disassembly";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Transport of the SLBP Dependant Mature mRNA";"Nuclear import of Rev protein";"Transcriptional regulation by small RNAs";"snRNP Assembly";"SUMOylation of DNA replication proteins"
XP_046411096.1	1	Reactome: R-HSA-1474151	"Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation"
XP_046436688.1	12	Reactome: R-HSA-5663220;Reactome: R-HSA-2500257;Reactome: R-HSA-6807878;Reactome: R-HSA-3371497;Reactome: R-HSA-2132295;Reactome: R-HSA-68877;Reactome: R-HSA-9609690;Reactome: R-HSA-9646399;Reactome: R-HSA-2467813;Reactome: R-HSA-6811436;Reactome: R-HSA-9648025;Reactome: R-HSA-141444	"RHO GTPases Activate Formins";"Resolution of Sister Chromatid Cohesion";"COPI-mediated anterograde transport";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"MHC class II antigen presentation";"Mitotic Prometaphase";"HCMV Early Events";"Aggrephagy";"Separation of Sister Chromatids";"COPI-independent Golgi-to-ER retrograde traffic";"EML4 and NUDC in mitotic spindle formation";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"
XP_046430829.1	1	Reactome: R-HSA-203927	"MicroRNA (miRNA) biogenesis"
XP_046434524.1	2	Reactome: R-HSA-390471;Reactome: R-HSA-429958	"Association of TriC/CCT with target proteins during biosynthesis";"mRNA decay by 3' to 5' exoribonuclease"
XP_046420220.1	5	Reactome: R-HSA-3214815;Reactome: R-HSA-350054;Reactome: R-HSA-2122947;Reactome: R-HSA-2894862;Reactome: R-HSA-2644606	"HDACs deacetylate histones";"Notch-HLH transcription pathway";"NOTCH1 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Constitutive Signaling by NOTCH1 PEST Domain Mutants"
XP_046431650.1	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
XP_046426071.1	5	Reactome: R-HSA-212300;Reactome: R-HSA-5334118;KEGG: 00270+2.1.1.37;Reactome: R-HSA-427413;Reactome: R-HSA-4655427	"PRC2 methylates histones and DNA";"DNA methylation";"Cysteine and methionine metabolism";"NoRC negatively regulates rRNA expression";"SUMOylation of DNA methylation proteins"
XP_046419895.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046413660.1	1	Reactome: R-HSA-9609523	"Insertion of tail-anchored proteins into the endoplasmic reticulum membrane"
XP_046430697.1	3	Reactome: R-HSA-379716;Reactome: R-HSA-2408522;KEGG: 00970+6.1.1.4	"Cytosolic tRNA aminoacylation";"Selenoamino acid metabolism";"Aminoacyl-tRNA biosynthesis"
XP_046421179.1	1	Reactome: R-HSA-3108214	"SUMOylation of DNA damage response and repair proteins"
XP_046430675.1	1	Reactome: R-HSA-189451	"Heme biosynthesis"
XP_046410127.1	6	KEGG: 00562+3.1.3.66;MetaCyc: PWY-6368;Reactome: R-HSA-1855183;Reactome: R-HSA-1660516;KEGG: 04070+3.1.3.66;Reactome: R-HSA-1660499	"Inositol phosphate metabolism";"3-phosphoinositide degradation";"Synthesis of IP2, IP, and Ins in the cytosol";"Synthesis of PIPs at the early endosome membrane";"Phosphatidylinositol signaling system";"Synthesis of PIPs at the plasma membrane"
XP_046425303.1	1	Reactome: R-HSA-73621	"Pyrimidine catabolism"
XP_046434765.1	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
XP_046434871.1	1	Reactome: R-HSA-1445148	"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
XP_046432786.1	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840	"Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation"
XP_046409359.1	3	Reactome: R-HSA-196807;Reactome: R-HSA-73621;Reactome: R-HSA-74259	"Nicotinate metabolism";"Pyrimidine catabolism";"Purine catabolism"
XP_046419147.1	2	Reactome: R-HSA-8939243;Reactome: R-HSA-3214858	"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RMTs methylate histone arginines"
XP_046424997.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046409557.1	5	Reactome: R-HSA-432722;Reactome: R-HSA-8856828;Reactome: R-HSA-8856825;Reactome: R-HSA-6798695;Reactome: R-HSA-6811440	"Golgi Associated Vesicle Biogenesis";"Clathrin-mediated endocytosis";"Cargo recognition for clathrin-mediated endocytosis";"Neutrophil degranulation";"Retrograde transport at the Trans-Golgi-Network"
XP_046415687.1	2	Reactome: R-HSA-6791226;Reactome: R-HSA-6784531	"Major pathway of rRNA processing in the nucleolus and cytosol";"tRNA processing in the nucleus"
XP_046419241.1	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
XP_046426148.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046426662.1	1	Reactome: R-HSA-373080	"Class B/2 (Secretin family receptors)"
XP_046430975.1	6	Reactome: R-HSA-8964539;MetaCyc: PWY-3341;KEGG: 00330+2.6.1.13;MetaCyc: PWY-4981;MetaCyc: PWY-6922;MetaCyc: PWY-6344	"Glutamate and glutamine metabolism";"L-proline biosynthesis III (from L-ornithine)";"Arginine and proline metabolism";"L-proline biosynthesis II (from arginine)";"L-Ndelta-acetylornithine biosynthesis";"L-ornithine degradation II (Stickland reaction)"
XP_046409979.1	2	Reactome: R-HSA-8939243;Reactome: R-HSA-3214858	"RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known";"RMTs methylate histone arginines"
XP_046409679.1	5	Reactome: R-HSA-1222556;Reactome: R-HSA-77387;Reactome: R-HSA-917977;Reactome: R-HSA-9639288;Reactome: R-HSA-983712	"ROS and RNS production in phagocytes";"Insulin receptor recycling";"Transferrin endocytosis and recycling";"Amino acids regulate mTORC1";"Ion channel transport"
XP_046433888.1	1	Reactome: R-HSA-380320	"Recruitment of NuMA to mitotic centrosomes"
XP_046427482.1	2	Reactome: R-HSA-5576892;Reactome: R-HSA-5576893	"Phase 0 - rapid depolarisation";"Phase 2 - plateau phase"
XP_046421954.1	2	Reactome: R-HSA-1296052;Reactome: R-HSA-418457	"Ca2+ activated K+ channels";"cGMP effects"
XP_046410509.1	6	Reactome: R-HSA-114508;KEGG: 00564+2.7.1.107;KEGG: 04070+2.7.1.107;KEGG: 00561+2.7.1.107;MetaCyc: PWY-7039;MetaCyc: PWY-7817	"Effects of PIP2 hydrolysis";"Glycerophospholipid metabolism";"Phosphatidylinositol signaling system";"Glycerolipid metabolism";"Phosphatidate metabolism, as a signaling molecule";"Type I lipoteichoic acid biosynthesis (S. aureus)"
XP_046412857.1	2	MetaCyc: PWY-7221;KEGG: 00230+2.7.4.8	"Guanosine ribonucleotides de novo biosynthesis";"Purine metabolism"
XP_046434987.1	4	Reactome: R-HSA-3214815;Reactome: R-HSA-8943724;Reactome: R-HSA-427389;Reactome: R-HSA-73762	"HDACs deacetylate histones";"Regulation of PTEN gene transcription";"ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression";"RNA Polymerase I Transcription Initiation"
XP_046428824.1	15	Reactome: R-HSA-1227986;Reactome: R-HSA-9664565;Reactome: R-HSA-9634285;Reactome: R-HSA-9665249;Reactome: R-HSA-9665233;Reactome: R-HSA-9665251;Reactome: R-HSA-9652282;Reactome: R-HSA-5637810;Reactome: R-HSA-1236382;Reactome: R-HSA-8863795;Reactome: R-HSA-9665250;Reactome: R-HSA-9665246;Reactome: R-HSA-9665247;Reactome: R-HSA-9665245;Reactome: R-HSA-9665244	"Signaling by ERBB2";"Signaling by ERBB2 KD Mutants";"Constitutive Signaling by Overexpressed ERBB2";"Resistance of ERBB2 KD mutants to afatinib";"Resistance of ERBB2 KD mutants to trastuzumab";"Resistance of ERBB2 KD mutants to lapatinib";"Drug-mediated inhibition of ERBB2 signaling";"Constitutive Signaling by EGFRvIII";"Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants";"Downregulation of ERBB2 signaling";"Resistance of ERBB2 KD mutants to AEE788";"Resistance of ERBB2 KD mutants to neratinib";"Resistance of ERBB2 KD mutants to osimertinib";"Resistance of ERBB2 KD mutants to tesevatinib";"Resistance of ERBB2 KD mutants to sapitinib"
XP_046431321.1	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
XP_046410387.1	4	Reactome: R-HSA-964975;KEGG: 00750+1.4.3.5;MetaCyc: PWY-7282;MetaCyc: PWY-7204	"Vitamins B6 activation to pyridoxal phosphate";"Vitamin B6 metabolism";"4-amino-2-methyl-5-phosphomethylpyrimidine biosynthesis";"Pyridoxal 5'-phosphate salvage II (plants)"
XP_046434280.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_046420725.1	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
XP_046418245.1	5	KEGG: 00620+4.1.1.32;MetaCyc: PWY-7383;Reactome: R-HSA-70263;KEGG: 00010+4.1.1.32;KEGG: 00020+4.1.1.32	"Pyruvate metabolism";"Anaerobic energy metabolism (invertebrates, cytosol)";"Gluconeogenesis";"Glycolysis / Gluconeogenesis";"Citrate cycle (TCA cycle)"
XP_046434153.1	13	Reactome: R-HSA-2022857;MetaCyc: PWY-7883;Reactome: R-HSA-1660662;KEGG: 00603+3.2.1.52;KEGG: 00511+3.2.1.52;KEGG: 00604+3.2.1.52;KEGG: 00531+3.2.1.52;Reactome: R-HSA-2160916;MetaCyc: PWY-7822;KEGG: 00513+3.2.1.52;MetaCyc: PWY-6902;Reactome: R-HSA-2024101;KEGG: 00520+3.2.1.52	"Keratan sulfate degradation";"Anhydromuropeptides recycling II";"Glycosphingolipid metabolism";"Glycosphingolipid biosynthesis - globo and isoglobo series";"Other glycan degradation";"Glycosphingolipid biosynthesis - ganglio series";"Glycosaminoglycan degradation";"Hyaluronan uptake and degradation";"Chitin degradation III (Serratia)";"Various types of N-glycan biosynthesis";"Chitin degradation II (Vibrio)";"CS/DS degradation";"Amino sugar and nucleotide sugar metabolism"
XP_046419432.1	1	Reactome: R-HSA-201681	"TCF dependent signaling in response to WNT"
XP_046420821.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046414971.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046413331.1	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
XP_046428833.1	1	Reactome: R-HSA-191859	"snRNP Assembly"
XP_046409704.1	1	Reactome: R-HSA-5662702	"Melanin biosynthesis"
XP_046419523.1	3	Reactome: R-HSA-8874081;Reactome: R-HSA-3000171;Reactome: R-HSA-3000157	"MET activates PTK2 signaling";"Non-integrin membrane-ECM interactions";"Laminin interactions"
XP_046427325.1	3	Reactome: R-HSA-429947;Reactome: R-HSA-380994;Reactome: R-HSA-450604	"Deadenylation of mRNA";"ATF4 activates genes in response to endoplasmic reticulum stress";"KSRP (KHSRP) binds and destabilizes mRNA"
XP_046428690.1	1	KEGG: 00760+2.3.1.286	"Nicotinate and nicotinamide metabolism"
XP_046414126.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_046419324.1	1	Reactome: R-HSA-5693565	"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"
XP_046429624.1	5	Reactome: R-HSA-3371571;Reactome: R-HSA-166208;Reactome: R-HSA-198323;Reactome: R-HSA-5674400;Reactome: R-HSA-165159	"HSF1-dependent transactivation";"mTORC1-mediated signalling";"AKT phosphorylates targets in the cytosol";"Constitutive Signaling by AKT1 E17K in Cancer";"mTOR signalling"
XP_046419734.1	3	KEGG: 00480+1.1.1.44;Reactome: R-HSA-71336;KEGG: 00030+1.1.1.44	"Glutathione metabolism";"Pentose phosphate pathway";"Pentose phosphate pathway"
XP_046434912.1	5	Reactome: R-HSA-6798695;Reactome: R-HSA-2029482;Reactome: R-HSA-5663213;Reactome: R-HSA-8856828;Reactome: R-HSA-3928662	"Neutrophil degranulation";"Regulation of actin dynamics for phagocytic cup formation";"RHO GTPases Activate WASPs and WAVEs";"Clathrin-mediated endocytosis";"EPHB-mediated forward signaling"
XP_046425274.1	4	KEGG: 00910+1.4.1.14;KEGG: 00250+1.4.1.14;MetaCyc: PWY-6963;Reactome: R-HSA-73621	"Nitrogen metabolism";"Alanine, aspartate and glutamate metabolism";"Ammonia assimilation cycle I";"Pyrimidine catabolism"
XP_046419657.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046412687.1	5	MetaCyc: PWY-7822;MetaCyc: PWY-6855;MetaCyc: PWY-6902;Reactome: R-HSA-189085;KEGG: 00520+3.2.1.14	"Chitin degradation III (Serratia)";"Chitin degradation I (archaea)";"Chitin degradation II (Vibrio)";"Digestion of dietary carbohydrate";"Amino sugar and nucleotide sugar metabolism"
XP_046410264.1	2	KEGG: 00620+3.1.2.6;MetaCyc: PWY-5386	"Pyruvate metabolism";"Methylglyoxal degradation I"
XP_046425679.1	4	Reactome: R-HSA-5696394;Reactome: R-HSA-8856825;Reactome: R-HSA-6781823;Reactome: R-HSA-8951664	"DNA Damage Recognition in GG-NER";"Cargo recognition for clathrin-mediated endocytosis";"Formation of TC-NER Pre-Incision Complex";"Neddylation"
XP_046424602.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046415437.1	1	Reactome: R-HSA-373080	"Class B/2 (Secretin family receptors)"
XP_046419245.1	5	Reactome: R-HSA-983189;Reactome: R-HSA-2132295;Reactome: R-HSA-1445148;Reactome: R-HSA-6811434;Reactome: R-HSA-5620924	"Kinesins";"MHC class II antigen presentation";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"COPI-dependent Golgi-to-ER retrograde traffic";"Intraflagellar transport"
XP_046435519.1	15	Reactome: R-HSA-5687128;Reactome: R-HSA-8853884;Reactome: R-HSA-9022692;Reactome: R-HSA-2559580;Reactome: R-HSA-9029569;Reactome: R-HSA-8936459;Reactome: R-HSA-8934593;Reactome: R-HSA-9018519;Reactome: R-HSA-5628897;Reactome: R-HSA-8948700;Reactome: R-HSA-2559585;Reactome: R-HSA-8986944;Reactome: R-HSA-4086398;Reactome: R-HSA-1912408;Reactome: R-HSA-8943723	"MAPK6/MAPK4 signaling";"Transcriptional Regulation by VENTX";"Regulation of MECP2 expression and activity";"Oxidative Stress Induced Senescence";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Regulation of RUNX1 Expression and Activity";"Estrogen-dependent gene expression";"TP53 Regulates Metabolic Genes";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"Oncogene Induced Senescence";"Transcriptional Regulation by MECP2";"Ca2+ pathway";"Pre-NOTCH Transcription and Translation";"Regulation of PTEN mRNA translation"
XP_046424064.1	11	Reactome: R-HSA-4420332;Reactome: R-HSA-3000170;Reactome: R-HSA-3560783;Reactome: R-HSA-3560801;Reactome: R-HSA-975634;Reactome: R-HSA-1971475;Reactome: R-HSA-3656253;Reactome: R-HSA-2022928;Reactome: R-HSA-2024096;Reactome: R-HSA-3656237;Reactome: R-HSA-202733	"Defective B3GALT6 causes EDSP2 and SEMDJL1";"Syndecan interactions";"Defective B4GALT7 causes EDS, progeroid type";"Defective B3GAT3 causes JDSSDHD";"Retinoid metabolism and transport";"A tetrasaccharide linker sequence is required for GAG synthesis";"Defective EXT1 causes exostoses 1, TRPS2 and CHDS";"HS-GAG biosynthesis";"HS-GAG degradation";"Defective EXT2 causes exostoses 2";"Cell surface interactions at the vascular wall"
XP_046436134.1	1	Reactome: R-HSA-6802952	"Signaling by BRAF and RAF fusions"
XP_046430871.1	4	Reactome: R-HSA-2161541;MetaCyc: PWY-7221;Reactome: R-HSA-499943;KEGG: 00230+2.7.4.8	"Abacavir metabolism";"Guanosine ribonucleotides de novo biosynthesis";"Interconversion of nucleotide di- and triphosphates";"Purine metabolism"
XP_046421046.1	5	MetaCyc: PWY-5084;KEGG: 00310+1.2.4.2;KEGG: 00380+1.2.4.2;KEGG: 00020+1.2.4.2;Reactome: R-HSA-389661	"2-oxoglutarate decarboxylation to succinyl-CoA";"Lysine degradation";"Tryptophan metabolism";"Citrate cycle (TCA cycle)";"Glyoxylate metabolism and glycine degradation"
XP_046422233.1	1	Reactome: R-HSA-1632852	"Macroautophagy"
XP_046420716.1	14	MetaCyc: PWY-7035;MetaCyc: PWY-8041;MetaCyc: PWY-7602;MetaCyc: PWY-6598;MetaCyc: PWY-7036;MetaCyc: PWY-5080;MetaCyc: PWY-7601;KEGG: 00062+2.3.1.199;MetaCyc: PWY-7619;MetaCyc: PWY-7725;MetaCyc: PWY-7724;Reactome: R-HSA-75876;MetaCyc: PWY-5972;MetaCyc: PWY-6433	"(9Z)-tricosene biosynthesis";"Ultra-long-chain fatty acid biosynthesis";"Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)";"Sciadonate biosynthesis";"Very long chain fatty acid biosynthesis II";"Very long chain fatty acid biosynthesis I";"Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)";"Fatty acid elongation";"Juniperonate biosynthesis";"Arachidonate biosynthesis V (8-detaturase, mammals)";"Icosapentaenoate biosynthesis III (8-desaturase, mammals)";"Synthesis of very long-chain fatty acyl-CoAs";"Stearate biosynthesis I (animals)";"Hydroxylated fatty acid biosynthesis (plants)"
XP_046424511.1	1	Reactome: R-HSA-1445148	"Translocation of SLC2A4 (GLUT4) to the plasma membrane"
XP_046428889.1	20	MetaCyc: PWY-735;KEGG: 00592+1.3.3.6;KEGG: 00640+1.3.3.6;MetaCyc: PWY-6837;KEGG: 00410+1.3.3.6;Reactome: R-HSA-9033241;MetaCyc: PWY-5136;MetaCyc: PWY-7858;MetaCyc: PWY-7291;MetaCyc: PWY-6920;KEGG: 00071+1.3.3.6;MetaCyc: PWY-7338;MetaCyc: PWY-7288;MetaCyc: PWY-7340;MetaCyc: PWY-7574;MetaCyc: PWY-7337;MetaCyc: PWY-7854;MetaCyc: PWY-7007;MetaCyc: PWY-7606;MetaCyc: PWY-7726	"Jasmonic acid biosynthesis";"alpha-Linolenic acid metabolism";"Propanoate metabolism";"Fatty acid beta-oxidation V (unsaturated, odd number, di-isomerase-dependent)";"beta-Alanine metabolism";"Peroxisomal protein import";"Fatty acid beta-oxidation II (plant peroxisome)";"(5Z)-dodecenoate biosynthesis II";"Oleate beta-oxidation (isomerase-dependent, yeast)";"6-gingerol analog biosynthesis (engineered)";"Fatty acid degradation";"10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast)";"Fatty acid beta-oxidation VII (yeast peroxisome)";"9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast)";"Propanoyl-coa degradation II";"10-cis-heptadecenoyl-CoA degradation (yeast)";"Crotonyl-coa/ethylmalonyl-coa/hydroxybutyryl-coa cycle (engineered)";"Methyl ketone biosynthesis (engineered)";"Docosahexaenoate biosynthesis III (6-desaturase, mammals)";"(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)"
XP_046421254.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046436438.1	5	Reactome: R-HSA-2871796;KEGG: 04150+2.7.11.24;Reactome: R-HSA-450321;Reactome: R-HSA-2559580;Reactome: R-HSA-450341	"FCERI mediated MAPK activation";"mTOR signaling pathway";"JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1";"Oxidative Stress Induced Senescence";"Activation of the AP-1 family of transcription factors"
XP_046415380.1	1	Reactome: R-HSA-111957	"Cam-PDE 1 activation"
XP_046435710.1	2	Reactome: R-HSA-2142753;KEGG: 00970+6.3.5.7	"Arachidonic acid metabolism";"Aminoacyl-tRNA biosynthesis"
XP_046410872.1	15	Reactome: R-HSA-113418;Reactome: R-HSA-112382;Reactome: R-HSA-167238;Reactome: R-HSA-167243;Reactome: R-HSA-167246;Reactome: R-HSA-75955;Reactome: R-HSA-6807505;Reactome: R-HSA-167290;Reactome: R-HSA-167152;Reactome: R-HSA-674695;Reactome: R-HSA-167158;Reactome: R-HSA-167242;Reactome: R-HSA-167287;Reactome: R-HSA-167200;Reactome: R-HSA-6796648	"Formation of the Early Elongation Complex";"Formation of RNA Pol II elongation complex";"Pausing and recovery of Tat-mediated HIV elongation";"Tat-mediated HIV elongation arrest and recovery";"Tat-mediated elongation of the HIV-1 transcript";"RNA Polymerase II Transcription Elongation";"RNA polymerase II transcribes snRNA genes";"Pausing and recovery of HIV elongation";"Formation of HIV elongation complex in the absence of HIV Tat";"RNA Polymerase II Pre-transcription Events";"Formation of the HIV-1 Early Elongation Complex";"Abortive elongation of HIV-1 transcript in the absence of Tat";"HIV elongation arrest and recovery";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"TP53 Regulates Transcription of DNA Repair Genes"
XP_046412878.1	4	Reactome: R-HSA-6798695;Reactome: R-HSA-2162123;KEGG: 00590+5.3.99.3;Reactome: R-HSA-499943	"Neutrophil degranulation";"Synthesis of Prostaglandins (PG) and Thromboxanes (TX)";"Arachidonic acid metabolism";"Interconversion of nucleotide di- and triphosphates"
XP_046423688.1	7	KEGG: 00970+6.1.1.17;MetaCyc: PWY-5188;KEGG: 00860+6.1.1.17;Reactome: R-HSA-6782315;Reactome: R-HSA-379716;KEGG: 00970+6.1.1.15;Reactome: R-HSA-2408522	"Aminoacyl-tRNA biosynthesis";"Tetrapyrrole biosynthesis I (from glutamate)";"Porphyrin and chlorophyll metabolism";"tRNA modification in the nucleus and cytosol";"Cytosolic tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis";"Selenoamino acid metabolism"
XP_046417735.1	2	Reactome: R-HSA-202733;Reactome: R-HSA-416993	"Cell surface interactions at the vascular wall";"Trafficking of GluR2-containing AMPA receptors"
XP_046423928.1	6	KEGG: 00073+1.2.1.84;MetaCyc: PWY-7656;Reactome: R-HSA-9640463;MetaCyc: PWY-6733;MetaCyc: PWY-7782;MetaCyc: PWY-5884	"Cutin, suberine and wax biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Wax biosynthesis";"Sporopollenin precursors biosynthesis";"Plasmalogen biosynthesis";"Wax esters biosynthesis I"
XP_046430482.1	4	Reactome: R-HSA-3769402;Reactome: R-HSA-201722;Reactome: R-HSA-2122947;Reactome: R-HSA-4641265	"Deactivation of the beta-catenin transactivating complex";"Formation of the beta-catenin:TCF transactivating complex";"NOTCH1 Intracellular Domain Regulates Transcription";"Repression of WNT target genes"
XP_046412506.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_046412301.1	2	Reactome: R-HSA-2173788;Reactome: R-HSA-5689603	"Downregulation of TGF-beta receptor signaling";"UCH proteinases"
XP_046435346.1	11	MetaCyc: PWY-6549;MetaCyc: PWY-6964;KEGG: 00910+6.3.1.2;MetaCyc: PWY-5675;Reactome: R-HSA-8964539;KEGG: 00630+6.3.1.2;Reactome: R-HSA-210455;MetaCyc: PWY-381;KEGG: 00220+6.3.1.2;MetaCyc: PWY-6963;KEGG: 00250+6.3.1.2	"L-glutamine biosynthesis III";"Ammonia assimilation cycle II";"Nitrogen metabolism";"Nitrate reduction V (assimilatory)";"Glutamate and glutamine metabolism";"Glyoxylate and dicarboxylate metabolism";"Astrocytic Glutamate-Glutamine Uptake And Metabolism";"Nitrate reduction II (assimilatory)";"Arginine biosynthesis";"Ammonia assimilation cycle I";"Alanine, aspartate and glutamate metabolism"
XP_046432695.1	2	Reactome: R-HSA-445095;Reactome: R-HSA-5576892	"Interaction between L1 and Ankyrins";"Phase 0 - rapid depolarisation"
XP_046416141.1	10	MetaCyc: PWY-8055;MetaCyc: PWY-8051;MetaCyc: PWY-6453;MetaCyc: PWY-5667;KEGG: 00564+2.3.1.15;KEGG: 00561+2.3.1.15;MetaCyc: PWY-7411;Reactome: R-HSA-1483166;MetaCyc: PWY-7587;MetaCyc: PWY-8053	"Palmitoyl ethanolamide biosynthesis";"Anandamide biosynthesis I";"Stigma estolide biosynthesis";"CDP-diacylglycerol biosynthesis I";"Glycerophospholipid metabolism";"Glycerolipid metabolism";"Phosphatidate biosynthesis (yeast)";"Synthesis of PA";"Oleate biosynthesis III (cyanobacteria)";"Anandamide biosynthesis II"
XP_046412795.1	2	KEGG: 00480+1.11.1.15;Reactome: R-HSA-3299685	"Glutathione metabolism";"Detoxification of Reactive Oxygen Species"
XP_046427253.1	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
XP_046412304.1	4	MetaCyc: PWY-6483;MetaCyc: PWY-7119;Reactome: R-HSA-1660662;KEGG: 00600+3.5.1.23	"Ceramide degradation (generic)";"Ceramide and sphingolipid recycling and degradation (yeast)";"Glycosphingolipid metabolism";"Sphingolipid metabolism"
XP_046421064.1	4	Reactome: R-HSA-983189;Reactome: R-HSA-2132295;Reactome: R-HSA-5625970;Reactome: R-HSA-6811434	"Kinesins";"MHC class II antigen presentation";"RHO GTPases activate KTN1";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_046413531.1	3	KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16;KEGG: 05235+3.1.3.16	"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation";"PD-L1 expression and PD-1 checkpoint pathway in cancer"
XP_046419156.1	9	Reactome: R-HSA-114608;Reactome: R-HSA-6802955;Reactome: R-HSA-6802952;Reactome: R-HSA-9649948;Reactome: R-HSA-6802948;Reactome: R-HSA-5674135;Reactome: R-HSA-6802946;Reactome: R-HSA-445355;Reactome: R-HSA-6798695	"Platelet degranulation";"Paradoxical activation of RAF signaling by kinase inactive BRAF";"Signaling by BRAF and RAF fusions";"Signaling downstream of RAS mutants";"Signaling by high-kinase activity BRAF mutants";"MAP2K and MAPK activation";"Signaling by moderate kinase activity BRAF mutants";"Smooth Muscle Contraction";"Neutrophil degranulation"
XP_046412965.1	13	KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04714+2.7.11.1;Reactome: R-HSA-3928662;KEGG: 04926+2.7.11.1;Reactome: R-HSA-416572;Reactome: R-HSA-5627117;KEGG: 05163+2.7.11.1;Reactome: R-HSA-4420097;KEGG: 04150+2.7.11.1;Reactome: R-HSA-3928663;KEGG: 04151+2.7.11.1;Reactome: R-HSA-416482	"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Thermogenesis";"EPHB-mediated forward signaling";"Relaxin signaling pathway";"Sema4D induced cell migration and growth-cone collapse";"RHO GTPases Activate ROCKs";"Human cytomegalovirus infection";"VEGFA-VEGFR2 Pathway";"mTOR signaling pathway";"EPHA-mediated growth cone collapse";"PI3K-Akt signaling pathway";"G alpha (12/13) signalling events"
XP_046411392.1	7	Reactome: R-HSA-380320;Reactome: R-HSA-2565942;Reactome: R-HSA-380270;Reactome: R-HSA-8854518;Reactome: R-HSA-380259;Reactome: R-HSA-380284;Reactome: R-HSA-5620912	"Recruitment of NuMA to mitotic centrosomes";"Regulation of PLK1 Activity at G2/M Transition";"Recruitment of mitotic centrosome proteins and complexes";"AURKA Activation by TPX2";"Loss of Nlp from mitotic centrosomes";"Loss of proteins required for interphase microtubule organization from the centrosome";"Anchoring of the basal body to the plasma membrane"
XP_046419333.1	4	Reactome: R-HSA-6794361;Reactome: R-HSA-8856828;Reactome: R-HSA-5250958;Reactome: R-HSA-8856825	"Neurexins and neuroligins";"Clathrin-mediated endocytosis";"Toxicity of botulinum toxin type B (BoNT/B)";"Cargo recognition for clathrin-mediated endocytosis"
XP_046425141.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_046430124.1	4	MetaCyc: PWY-7382;KEGG: 00785+2.8.1.8;MetaCyc: PWY-6987;Reactome: R-HSA-389661	"Lipoate biosynthesis and incorporation IV (yeast)";"Lipoic acid metabolism";"Lipoate biosynthesis and incorporation III (Bacillus)";"Glyoxylate metabolism and glycine degradation"
XP_046423421.1	1	Reactome: R-HSA-4551638	"SUMOylation of chromatin organization proteins"
XP_046419545.1	2	Reactome: R-HSA-163841;KEGG: 00900+2.1.1.100	"Gamma carboxylation, hypusine formation and arylsulfatase activation";"Terpenoid backbone biosynthesis"
XP_046425876.1	3	Reactome: R-HSA-5578775;Reactome: R-HSA-936837;Reactome: R-HSA-418359	"Ion homeostasis";"Ion transport by P-type ATPases";"Reduction of cytosolic Ca++ levels"
XP_046417627.1	2	Reactome: R-HSA-416476;Reactome: R-HSA-375281	"G alpha (q) signalling events";"Hormone ligand-binding receptors"
XP_046412606.1	1	Reactome: R-HSA-176974	"Unwinding of DNA"
XP_046421291.1	7	KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1	"Relaxin signaling pathway";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Human cytomegalovirus infection";"Thermogenesis";"PI3K-Akt signaling pathway";"mTOR signaling pathway"
XP_046410841.1	1	Reactome: R-HSA-209968	"Thyroxine biosynthesis"
XP_046426753.1	1	Reactome: R-HSA-110320	"Translesion Synthesis by POLH"
XP_046423574.1	9	Reactome: R-HSA-73779;Reactome: R-HSA-73776;Reactome: R-HSA-674695;Reactome: R-HSA-167161;Reactome: R-HSA-6807505;Reactome: R-HSA-167162;Reactome: R-HSA-167172;Reactome: R-HSA-75953;Reactome: R-HSA-76042	"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"RNA Polymerase II Promoter Escape";"RNA Polymerase II Pre-transcription Events";"HIV Transcription Initiation";"RNA polymerase II transcribes snRNA genes";"RNA Polymerase II HIV Promoter Escape";"Transcription of the HIV genome";"RNA Polymerase II Transcription Initiation";"RNA Polymerase II Transcription Initiation And Promoter Clearance"
XP_046426177.1	2	Reactome: R-HSA-389661;Reactome: R-HSA-9033241	"Glyoxylate metabolism and glycine degradation";"Peroxisomal protein import"
XP_046422176.1	1	KEGG: 00970+6.1.1.21	"Aminoacyl-tRNA biosynthesis"
XP_046426791.1	6	MetaCyc: PWY-6118;Reactome: R-HSA-163560;Reactome: R-HSA-1483166;KEGG: 00564+1.1.5.3;MetaCyc: PWY-6952;MetaCyc: PWY-4261	"Glycerol-3-phosphate shuttle";"Triglyceride catabolism";"Synthesis of PA";"Glycerophospholipid metabolism";"Glycerophosphodiester degradation";"Glycerol degradation I"
XP_046414507.1	3	KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;KEGG: 04658+3.1.3.16	"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"Th1 and Th2 cell differentiation"
XP_046410105.1	10	Reactome: R-HSA-6798695;Reactome: R-HSA-2453902;MetaCyc: PWY-7394;MetaCyc: PWY-7849;KEGG: 00230+3.5.2.17;Reactome: R-HSA-977225;Reactome: R-HSA-2453864;Reactome: R-HSA-3000171;MetaCyc: PWY-5691;Reactome: R-HSA-975634	"Neutrophil degranulation";"The canonical retinoid cycle in rods (twilight vision)";"Urate conversion to allantoin II";"Urate conversion to allantoin III";"Purine metabolism";"Amyloid fiber formation";"Retinoid cycle disease events";"Non-integrin membrane-ECM interactions";"Urate conversion to allantoin I";"Retinoid metabolism and transport"
XP_046433915.1	1	Reactome: R-HSA-9633012	"Response of EIF2AK4 (GCN2) to amino acid deficiency"
XP_046413547.1	7	Reactome: R-HSA-2691232;MetaCyc: PWY-7511;Reactome: R-HSA-2979096;Reactome: R-HSA-2644606;Reactome: R-HSA-9013507;Reactome: R-HSA-2894862;Reactome: R-HSA-2122948	"Constitutive Signaling by NOTCH1 HD Domain Mutants";"Protein ubiquitination";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Activated NOTCH1 Transmits Signal to the Nucleus"
XP_046431698.1	1	Reactome: R-HSA-1237044	"Erythrocytes take up carbon dioxide and release oxygen"
XP_046425788.1	2	Reactome: R-HSA-3299685;MetaCyc: PWY-6854	"Detoxification of Reactive Oxygen Species";"Ethylene biosynthesis III (microbes)"
XP_046416560.1	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
XP_046414631.1	5	Reactome: R-HSA-5620922;Reactome: R-HSA-5632684;Reactome: R-HSA-5610787;Reactome: R-HSA-5635838;Reactome: R-HSA-373080	"BBSome-mediated cargo-targeting to cilium";"Hedgehog 'on' state";"Hedgehog 'off' state";"Activation of SMO";"Class B/2 (Secretin family receptors)"
XP_046427032.1	3	MetaCyc: PWY-5491;KEGG: 00790+3.1.3.1;KEGG: 00730+3.1.3.1	"Diethylphosphate degradation";"Folate biosynthesis";"Thiamine metabolism"
XP_046425776.1	20	Reactome: R-HSA-176187;Reactome: R-HSA-5693616;Reactome: R-HSA-5656169;Reactome: R-HSA-69473;Reactome: R-HSA-6804756;Reactome: R-HSA-69091;Reactome: R-HSA-5696397;Reactome: R-HSA-5656121;Reactome: R-HSA-110314;Reactome: R-HSA-5655862;Reactome: R-HSA-6782135;Reactome: R-HSA-110320;Reactome: R-HSA-5696400;Reactome: R-HSA-5685938;Reactome: R-HSA-110312;Reactome: R-HSA-174411;Reactome: R-HSA-5651801;Reactome: R-HSA-5693607;Reactome: R-HSA-5685942;Reactome: R-HSA-6782210	"Activation of ATR in response to replication stress";"Presynaptic phase of homologous DNA pairing and strand exchange";"Termination of translesion DNA synthesis";"G2/M DNA damage checkpoint";"Regulation of TP53 Activity through Phosphorylation";"Polymerase switching";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Translesion synthesis by POLI";"Recognition of DNA damage by PCNA-containing replication complex";"Translesion synthesis by POLK";"Dual incision in TC-NER";"Translesion Synthesis by POLH";"Dual Incision in GG-NER";"HDR through Single Strand Annealing (SSA)";"Translesion synthesis by REV1";"Polymerase switching on the C-strand of the telomere";"PCNA-Dependent Long Patch Base Excision Repair";"Processing of DNA double-strand break ends";"HDR through Homologous Recombination (HRR)";"Gap-filling DNA repair synthesis and ligation in TC-NER"
XP_046424047.1	2	Reactome: R-HSA-6799198;Reactome: R-HSA-611105	"Complex I biogenesis";"Respiratory electron transport"
XP_046432841.1	3	Reactome: R-HSA-73856;Reactome: R-HSA-72187;Reactome: R-HSA-159236	"RNA Polymerase II Transcription Termination";"mRNA 3'-end processing";"Transport of Mature mRNA derived from an Intron-Containing Transcript"
XP_046419992.1	2	Reactome: R-HSA-1236974;Reactome: R-HSA-1799339	"ER-Phagosome pathway";"SRP-dependent cotranslational protein targeting to membrane"
XP_046432284.1	5	MetaCyc: PWY-7921;KEGG: 00514+2.4.1.109;MetaCyc: PWY-7979;KEGG: 00515+2.4.1.109;MetaCyc: PWY-7922	"Protein O-mannosylation I (yeast)";"Other types of O-glycan biosynthesis";"Protein O-mannosylation III (mammals, core M3)";"Mannose type O-glycan biosynthesis";"Protein O-mannosylation II (mammals, core M1 and core M2)"
XP_046421974.1	2	Reactome: R-HSA-418457;Reactome: R-HSA-1296052	"cGMP effects";"Ca2+ activated K+ channels"
XP_046409893.1	1	Reactome: R-HSA-77289	"Mitochondrial Fatty Acid Beta-Oxidation"
XP_046424938.1	1	Reactome: R-HSA-432720	"Lysosome Vesicle Biogenesis"
XP_046421559.1	1	Reactome: R-HSA-162658	"Golgi Cisternae Pericentriolar Stack Reorganization"
XP_046429399.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_046414863.1	2	KEGG: 00970+6.1.1.3;Reactome: R-HSA-114608	"Aminoacyl-tRNA biosynthesis";"Platelet degranulation"
XP_046427170.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046430224.1	1	Reactome: R-HSA-2514859	"Inactivation, recovery and regulation of the phototransduction cascade"
XP_046432722.1	6	KEGG: 00513+2.4.1.143;MetaCyc: PWY-7920;MetaCyc: PWY-7426;KEGG: 00510+2.4.1.143;Reactome: R-HSA-4793952;Reactome: R-HSA-975578	"Various types of N-glycan biosynthesis";"Complex N-linked glycan biosynthesis (plants)";"Complex N-linked glycan biosynthesis (vertebrates)";"N-Glycan biosynthesis";"Defective MGAT2 causes MGAT2-CDG (CDG-2a)";"Reactions specific to the complex N-glycan synthesis pathway"
XP_046413671.1	1	Reactome: R-HSA-5419276	"Mitochondrial translation termination"
XP_046433027.1	10	Reactome: R-HSA-2122947;Reactome: R-HSA-2644606;Reactome: R-HSA-9013508;Reactome: R-HSA-350054;Reactome: R-HSA-2894862;Reactome: R-HSA-2197563;Reactome: R-HSA-9013695;Reactome: R-HSA-8941856;Reactome: R-HSA-1912408;Reactome: R-HSA-210744	"NOTCH1 Intracellular Domain Regulates Transcription";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH3 Intracellular Domain Regulates Transcription";"Notch-HLH transcription pathway";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"NOTCH2 intracellular domain regulates transcription";"NOTCH4 Intracellular Domain Regulates Transcription";"RUNX3 regulates NOTCH signaling";"Pre-NOTCH Transcription and Translation";"Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells"
XP_046411698.1	5	Reactome: R-HSA-5685939;Reactome: R-HSA-5649702;Reactome: R-HSA-5696397;Reactome: R-HSA-6782210;Reactome: R-HSA-110381	"HDR through MMEJ (alt-NHEJ)";"APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway";"Gap-filling DNA repair synthesis and ligation in GG-NER";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Resolution of AP sites via the single-nucleotide replacement pathway"
XP_046413276.1	16	Reactome: R-HSA-8936459;Reactome: R-HSA-9018519;Reactome: R-HSA-2559585;Reactome: R-HSA-8948700;Reactome: R-HSA-5628897;Reactome: R-HSA-8943723;Reactome: R-HSA-1912408;Reactome: R-HSA-8986944;Reactome: R-HSA-8934593;Reactome: R-HSA-4086398;Reactome: R-HSA-8853884;Reactome: R-HSA-5687128;Reactome: R-HSA-9022692;Reactome: R-HSA-426496;Reactome: R-HSA-9029569;Reactome: R-HSA-2559580	"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Estrogen-dependent gene expression";"Oncogene Induced Senescence";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"TP53 Regulates Metabolic Genes";"Regulation of PTEN mRNA translation";"Pre-NOTCH Transcription and Translation";"Transcriptional Regulation by MECP2";"Regulation of RUNX1 Expression and Activity";"Ca2+ pathway";"Transcriptional Regulation by VENTX";"MAPK6/MAPK4 signaling";"Regulation of MECP2 expression and activity";"Post-transcriptional silencing by small RNAs";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Oxidative Stress Induced Senescence"
XP_046418833.1	1	Reactome: R-HSA-83936	"Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"
XP_046409341.1	1	KEGG: 04070+2.7.11.13	"Phosphatidylinositol signaling system"
XP_046430375.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046431330.1	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
XP_046423340.1	2	KEGG: 00230+3.1.4.53;Reactome: R-HSA-180024	"Purine metabolism";"DARPP-32 events"
XP_046420868.1	33	Reactome: R-HSA-165054;Reactome: R-HSA-4085377;Reactome: R-HSA-6784531;Reactome: R-HSA-170822;Reactome: R-HSA-180910;Reactome: R-HSA-141444;Reactome: R-HSA-159236;Reactome: R-HSA-168325;Reactome: R-HSA-9609690;Reactome: R-HSA-4570464;Reactome: R-HSA-159227;Reactome: R-HSA-168333;Reactome: R-HSA-5663220;Reactome: R-HSA-180746;Reactome: R-HSA-5578749;Reactome: R-HSA-68877;Reactome: R-HSA-3301854;Reactome: R-HSA-4551638;Reactome: R-HSA-3232142;Reactome: R-HSA-2500257;Reactome: R-HSA-3371453;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813;Reactome: R-HSA-159231;Reactome: R-HSA-3108214;Reactome: R-HSA-1169408;Reactome: R-HSA-9610379;Reactome: R-HSA-168271;Reactome: R-HSA-191859;Reactome: R-HSA-159230;Reactome: R-HSA-4615885;Reactome: R-HSA-5619107;Reactome: R-HSA-168276	"Rev-mediated nuclear export of HIV RNA";"SUMOylation of SUMOylation proteins";"tRNA processing in the nucleus";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Vpr-mediated nuclear import of PICs";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Viral Messenger RNA Synthesis";"HCMV Early Events";"SUMOylation of RNA binding proteins";"Transport of the SLBP independent Mature mRNA";"NEP/NS2 Interacts with the Cellular Export Machinery";"RHO GTPases Activate Formins";"Nuclear import of Rev protein";"Transcriptional regulation by small RNAs";"Mitotic Prometaphase";"Nuclear Pore Complex (NPC) Disassembly";"SUMOylation of chromatin organization proteins";"SUMOylation of ubiquitinylation proteins";"Resolution of Sister Chromatid Cohesion";"Regulation of HSF1-mediated heat shock response";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids";"Transport of Mature mRNA Derived from an Intronless Transcript";"SUMOylation of DNA damage response and repair proteins";"ISG15 antiviral mechanism";"HCMV Late Events";"Transport of Ribonucleoproteins into the Host Nucleus";"snRNP Assembly";"Transport of the SLBP Dependant Mature mRNA";"SUMOylation of DNA replication proteins";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"NS1 Mediated Effects on Host Pathways"
XP_046427920.1	4	Reactome: R-HSA-379726;KEGG: 00970+6.1.1.17;KEGG: 00860+6.1.1.17;MetaCyc: PWY-5188	"Mitochondrial tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis";"Porphyrin and chlorophyll metabolism";"Tetrapyrrole biosynthesis I (from glutamate)"
XP_046424901.1	6	Reactome: R-HSA-380994;Reactome: R-HSA-429958;Reactome: R-HSA-450604;Reactome: R-HSA-450513;Reactome: R-HSA-6791226;Reactome: R-HSA-450385	"ATF4 activates genes in response to endoplasmic reticulum stress";"mRNA decay by 3' to 5' exoribonuclease";"KSRP (KHSRP) binds and destabilizes mRNA";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"Major pathway of rRNA processing in the nucleolus and cytosol";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA"
XP_046418096.1	1	Reactome: R-HSA-3214858	"RMTs methylate histone arginines"
XP_046436439.1	5	Reactome: R-HSA-2871796;KEGG: 04150+2.7.11.24;Reactome: R-HSA-2559580;Reactome: R-HSA-450321;Reactome: R-HSA-450341	"FCERI mediated MAPK activation";"mTOR signaling pathway";"Oxidative Stress Induced Senescence";"JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1";"Activation of the AP-1 family of transcription factors"
XP_046429979.1	6	Reactome: R-HSA-6803205;Reactome: R-HSA-6803207;Reactome: R-HSA-6803211;Reactome: R-HSA-6803204;Reactome: R-HSA-139915;Reactome: R-HSA-6804759	"TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain";"TP53 Regulates Transcription of Caspase Activators and Caspases";"TP53 Regulates Transcription of Death Receptors and Ligands";"TP53 Regulates Transcription of Genes Involved in Cytochrome C Release";"Activation of PUMA and translocation to mitochondria";"Regulation of TP53 Activity through Association with Co-factors"
XP_046431468.1	2	Reactome: R-HSA-373080;Reactome: R-HSA-3238698	"Class B/2 (Secretin family receptors)";"WNT ligand biogenesis and trafficking"
XP_046409920.1	1	Reactome: R-HSA-373080	"Class B/2 (Secretin family receptors)"
XP_046430913.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046412228.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046425692.1	18	MetaCyc: PWY-7383;KEGG: 00950+2.6.1.1;MetaCyc: PWY-5913;KEGG: 00360+2.6.1.1;MetaCyc: PWY-7115;MetaCyc: PWY-6642;KEGG: 00401+2.6.1.1;MetaCyc: PWY-6638;KEGG: 00400+2.6.1.1;KEGG: 00220+2.6.1.1;KEGG: 00250+2.6.1.1;MetaCyc: PWY-7117;KEGG: 00330+2.6.1.1;MetaCyc: PWY-6643;KEGG: 00960+2.6.1.1;KEGG: 00270+2.6.1.1;KEGG: 00710+2.6.1.1;KEGG: 00350+2.6.1.1	"Anaerobic energy metabolism (invertebrates, cytosol)";"Isoquinoline alkaloid biosynthesis";"Partial TCA cycle (obligate autotrophs)";"Phenylalanine metabolism";"C4 photosynthetic carbon assimilation cycle, NAD-ME type";"(R)-cysteate degradation";"Novobiocin biosynthesis";"Sulfolactate degradation III";"Phenylalanine, tyrosine and tryptophan biosynthesis";"Arginine biosynthesis";"Alanine, aspartate and glutamate metabolism";"C4 photosynthetic carbon assimilation cycle, PEPCK type";"Arginine and proline metabolism";"Coenzyme M biosynthesis II";"Tropane, piperidine and pyridine alkaloid biosynthesis";"Cysteine and methionine metabolism";"Carbon fixation in photosynthetic organisms";"Tyrosine metabolism"
XP_046423161.1	2	Reactome: R-HSA-163210;Reactome: R-HSA-8949613	"Formation of ATP by chemiosmotic coupling";"Cristae formation"
XP_046426419.1	2	KEGG: 00561+2.7.1.30;MetaCyc: PWY-4261	"Glycerolipid metabolism";"Glycerol degradation I"
XP_046428455.1	18	MetaCyc: PWY-7417;Reactome: R-HSA-1482801;KEGG: 00590+3.1.1.4;Reactome: R-HSA-1483166;KEGG: 00592+3.1.1.4;Reactome: R-HSA-1482922;MetaCyc: PWY-8051;Reactome: R-HSA-1482788;KEGG: 00565+3.1.1.4;KEGG: 00591+3.1.1.4;KEGG: 00564+3.1.1.4;MetaCyc: PWY-7409;Reactome: R-HSA-1482839;MetaCyc: PWY-7416;MetaCyc: PWY-8053;MetaCyc: PWY-7783;MetaCyc: PWY-6803;Reactome: R-HSA-1482925	"Phospholipid remodeling (phosphatidate, yeast)";"Acyl chain remodelling of PS";"Arachidonic acid metabolism";"Synthesis of PA";"alpha-Linolenic acid metabolism";"Acyl chain remodelling of PI";"Anandamide biosynthesis I";"Acyl chain remodelling of PC";"Ether lipid metabolism";"Linoleic acid metabolism";"Glycerophospholipid metabolism";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Acyl chain remodelling of PE";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Anandamide biosynthesis II";"Plasmalogen degradation";"Phosphatidylcholine acyl editing";"Acyl chain remodelling of PG"
XP_046419924.1	8	KEGG: 00515+2.4.1.109;MetaCyc: PWY-7979;Reactome: R-HSA-5083633;MetaCyc: PWY-7921;KEGG: 00514+2.4.1.109;MetaCyc: PWY-7922;Reactome: R-HSA-5083629;Reactome: R-HSA-5173105	"Mannose type O-glycan biosynthesis";"Protein O-mannosylation III (mammals, core M3)";"Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1";"Protein O-mannosylation I (yeast)";"Other types of O-glycan biosynthesis";"Protein O-mannosylation II (mammals, core M1 and core M2)";"Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2";"O-linked glycosylation"
XP_046410566.1	2	Reactome: R-HSA-418594;Reactome: R-HSA-375276	"G alpha (i) signalling events";"Peptide ligand-binding receptors"
XP_046426738.1	8	Reactome: R-HSA-380972;Reactome: R-HSA-165159;Reactome: R-HSA-1632852;Reactome: R-HSA-166208;Reactome: R-HSA-5628897;Reactome: R-HSA-9639288;Reactome: R-HSA-8943724;Reactome: R-HSA-3371571	"Energy dependent regulation of mTOR by LKB1-AMPK";"mTOR signalling";"Macroautophagy";"mTORC1-mediated signalling";"TP53 Regulates Metabolic Genes";"Amino acids regulate mTORC1";"Regulation of PTEN gene transcription";"HSF1-dependent transactivation"
XP_046429746.1	2	Reactome: R-HSA-8856825;Reactome: R-HSA-8856828	"Cargo recognition for clathrin-mediated endocytosis";"Clathrin-mediated endocytosis"
XP_046428425.1	7	KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1	"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Relaxin signaling pathway";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Human cytomegalovirus infection";"Thermogenesis"
XP_046421048.1	5	Reactome: R-HSA-389661;KEGG: 00020+1.2.4.2;KEGG: 00310+1.2.4.2;MetaCyc: PWY-5084;KEGG: 00380+1.2.4.2	"Glyoxylate metabolism and glycine degradation";"Citrate cycle (TCA cycle)";"Lysine degradation";"2-oxoglutarate decarboxylation to succinyl-CoA";"Tryptophan metabolism"
XP_046429184.1	18	KEGG: 00564+3.1.1.4;KEGG: 00591+3.1.1.4;MetaCyc: PWY-7416;Reactome: R-HSA-1482839;MetaCyc: PWY-8053;MetaCyc: PWY-7409;MetaCyc: PWY-7783;Reactome: R-HSA-1482925;MetaCyc: PWY-6803;MetaCyc: PWY-7417;Reactome: R-HSA-1482801;KEGG: 00592+3.1.1.4;Reactome: R-HSA-1483166;KEGG: 00590+3.1.1.4;Reactome: R-HSA-1482788;KEGG: 00565+3.1.1.4;Reactome: R-HSA-1482922;MetaCyc: PWY-8051	"Glycerophospholipid metabolism";"Linoleic acid metabolism";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Acyl chain remodelling of PE";"Anandamide biosynthesis II";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Plasmalogen degradation";"Acyl chain remodelling of PG";"Phosphatidylcholine acyl editing";"Phospholipid remodeling (phosphatidate, yeast)";"Acyl chain remodelling of PS";"alpha-Linolenic acid metabolism";"Synthesis of PA";"Arachidonic acid metabolism";"Acyl chain remodelling of PC";"Ether lipid metabolism";"Acyl chain remodelling of PI";"Anandamide biosynthesis I"
XP_046415786.1	2	KEGG: 00970+6.1.1.20;Reactome: R-HSA-379726	"Aminoacyl-tRNA biosynthesis";"Mitochondrial tRNA aminoacylation"
XP_046427486.1	2	Reactome: R-HSA-5576893;Reactome: R-HSA-5576892	"Phase 2 - plateau phase";"Phase 0 - rapid depolarisation"
XP_046411786.1	6	KEGG: 00730+2.7.6.2;MetaCyc: PWY-7356;MetaCyc: PWY-6898;Reactome: R-HSA-196819;MetaCyc: PWY-6908;MetaCyc: PWY-6907	"Thiamine metabolism";"Thiamine salvage IV (yeast)";"Thiamine salvage III";"Vitamin B1 (thiamin) metabolism";"Thiamine diphosphate biosynthesis IV (eukaryotes)";"Thiamine diphosphate biosynthesis III (Staphylococcus)"
XP_046417540.1	2	Reactome: R-HSA-936837;Reactome: R-HSA-6798695	"Ion transport by P-type ATPases";"Neutrophil degranulation"
XP_046423714.1	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
XP_046418265.1	29	Reactome: R-HSA-5685938;Reactome: R-HSA-5693554;Reactome: R-HSA-6803204;Reactome: R-HSA-5693568;KEGG: 05165+2.7.11.1;Reactome: R-HSA-349425;Reactome: R-HSA-5693579;Reactome: R-HSA-2559586;Reactome: R-HSA-5693548;Reactome: R-HSA-912446;Reactome: R-HSA-5693607;Reactome: R-HSA-5685942;Reactome: R-HSA-6804757;KEGG: 05163+2.7.11.1;Reactome: R-HSA-69541;Reactome: R-HSA-6804760;Reactome: R-HSA-69473;KEGG: 04926+2.7.11.1;Reactome: R-HSA-5693571;Reactome: R-HSA-6804756;KEGG: 04151+2.7.11.1;Reactome: R-HSA-5693616;Reactome: R-HSA-6796648;KEGG: 04150+2.7.11.1;KEGG: 04714+2.7.11.1;Reactome: R-HSA-6803207;KEGG: 05170+2.7.11.1;Reactome: R-HSA-5693565;Reactome: R-HSA-3371453	"HDR through Single Strand Annealing (SSA)";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"TP53 Regulates Transcription of Genes Involved in Cytochrome C Release";"Resolution of D-loop Structures through Holliday Junction Intermediates";"Human papillomavirus infection";"Autodegradation of the E3 ubiquitin ligase COP1";"Homologous DNA Pairing and Strand Exchange";"DNA Damage/Telomere Stress Induced Senescence";"Sensing of DNA Double Strand Breaks";"Meiotic recombination";"Processing of DNA double-strand break ends";"HDR through Homologous Recombination (HRR)";"Regulation of TP53 Degradation";"Human cytomegalovirus infection";"Stabilization of p53";"Regulation of TP53 Activity through Methylation";"G2/M DNA damage checkpoint";"Relaxin signaling pathway";"Nonhomologous End-Joining (NHEJ)";"Regulation of TP53 Activity through Phosphorylation";"PI3K-Akt signaling pathway";"Presynaptic phase of homologous DNA pairing and strand exchange";"TP53 Regulates Transcription of DNA Repair Genes";"mTOR signaling pathway";"Thermogenesis";"TP53 Regulates Transcription of Caspase Activators and Caspases";"Human immunodeficiency virus 1 infection";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Regulation of HSF1-mediated heat shock response"
XP_046412524.1	4	Reactome: R-HSA-216083;Reactome: R-HSA-2129379;Reactome: R-HSA-3000170;Reactome: R-HSA-3000178	"Integrin cell surface interactions";"Molecules associated with elastic fibres";"Syndecan interactions";"ECM proteoglycans"
XP_046410690.1	14	MetaCyc: PWY-6901;MetaCyc: PWY-1622;MetaCyc: PWY-7218;MetaCyc: PWY-6886;MetaCyc: PWY-6142;MetaCyc: PWY-5723;KEGG: 00010+4.2.1.11;MetaCyc: PWY-2221;MetaCyc: PWY-8004;MetaCyc: PWY-7124;MetaCyc: PWY-1042;MetaCyc: PWY-7003;MetaCyc: PWY-5484;KEGG: 00680+4.2.1.11	"Superpathway of glucose and xylose degradation";"Formaldehyde assimilation I (serine pathway)";"Photosynthetic 3-hydroxybutanoate biosynthesis (engineered)";"1-butanol autotrophic biosynthesis (engineered)";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Rubisco shunt";"Glycolysis / Gluconeogenesis";"Entner-Doudoroff pathway III (semi-phosphorylative)";"Entner-Doudoroff pathway I";"Ethylene biosynthesis V (engineered)";"Glycolysis IV (plant cytosol)";"Glycerol degradation to butanol";"Glycolysis II (from fructose 6-phosphate)";"Methane metabolism"
XP_046422328.1	1	Reactome: R-HSA-5663220	"RHO GTPases Activate Formins"
XP_046436402.1	1	Reactome: R-HSA-6811436	"COPI-independent Golgi-to-ER retrograde traffic"
XP_046420637.1	2	Reactome: R-HSA-379726;KEGG: 00970+6.1.1.5	"Mitochondrial tRNA aminoacylation";"Aminoacyl-tRNA biosynthesis"
XP_046436008.1	6	KEGG: 00561+2.7.1.107;MetaCyc: PWY-7039;MetaCyc: PWY-7817;KEGG: 00564+2.7.1.107;Reactome: R-HSA-114508;KEGG: 04070+2.7.1.107	"Glycerolipid metabolism";"Phosphatidate metabolism, as a signaling molecule";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Glycerophospholipid metabolism";"Effects of PIP2 hydrolysis";"Phosphatidylinositol signaling system"
XP_046410886.1	3	Reactome: R-HSA-76061;Reactome: R-HSA-76066;Reactome: R-HSA-749476	"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Abortive And Retractive Initiation"
XP_046422258.1	6	Reactome: R-HSA-114516;Reactome: R-HSA-416993;Reactome: R-HSA-76005;KEGG: 04070+2.7.11.13;Reactome: R-HSA-5099900;Reactome: R-HSA-418597	"Disinhibition of SNARE formation";"Trafficking of GluR2-containing AMPA receptors";"Response to elevated platelet cytosolic Ca2+";"Phosphatidylinositol signaling system";"WNT5A-dependent internalization of FZD4";"G alpha (z) signalling events"
XP_046414503.1	1	Reactome: R-HSA-9609523	"Insertion of tail-anchored proteins into the endoplasmic reticulum membrane"
XP_046419076.1	1	Reactome: R-HSA-5658442	"Regulation of RAS by GAPs"
XP_046428122.1	1	Reactome: R-HSA-1474228	"Degradation of the extracellular matrix"
XP_046426806.1	1	Reactome: R-HSA-3214858	"RMTs methylate histone arginines"
XP_046419074.1	1	Reactome: R-HSA-5658442	"Regulation of RAS by GAPs"
XP_046418903.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046425872.1	3	Reactome: R-HSA-418359;Reactome: R-HSA-936837;Reactome: R-HSA-5578775	"Reduction of cytosolic Ca++ levels";"Ion transport by P-type ATPases";"Ion homeostasis"
XP_046428470.1	6	Reactome: R-HSA-8957275;Reactome: R-HSA-8963889;Reactome: R-HSA-381426;Reactome: R-HSA-8874211;Reactome: R-HSA-1655829;Reactome: R-HSA-381033	"Post-translational protein phosphorylation";"Assembly of active LPL and LIPC lipase complexes";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"CREB3 factors activate genes";"Regulation of cholesterol biosynthesis by SREBP (SREBF)";"ATF6 (ATF6-alpha) activates chaperones"
XP_046424331.1	1	Reactome: R-HSA-499943	"Interconversion of nucleotide di- and triphosphates"
XP_046430524.1	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046420666.1	2	KEGG: 00030+2.7.6.1;KEGG: 00230+2.7.6.1	"Pentose phosphate pathway";"Purine metabolism"
XP_046419300.1	2	Reactome: R-HSA-6811434;Reactome: R-HSA-983189	"COPI-dependent Golgi-to-ER retrograde traffic";"Kinesins"
XP_046415461.1	24	Reactome: R-HSA-5626467;Reactome: R-HSA-6807878;Reactome: R-HSA-9619483;Reactome: R-HSA-1445148;Reactome: R-HSA-983189;Reactome: R-HSA-2500257;Reactome: R-HSA-9648025;Reactome: R-HSA-380320;Reactome: R-HSA-9609690;Reactome: R-HSA-2467813;Reactome: R-HSA-6811434;Reactome: R-HSA-3371497;Reactome: R-HSA-5663220;Reactome: R-HSA-437239;Reactome: R-HSA-8955332;Reactome: R-HSA-9609736;Reactome: R-HSA-8852276;Reactome: R-HSA-68877;Reactome: R-HSA-190840;Reactome: R-HSA-190861;Reactome: R-HSA-9646399;Reactome: R-HSA-6811436;Reactome: R-HSA-5617833;Reactome: R-HSA-2132295	"RHO GTPases activate IQGAPs";"COPI-mediated anterograde transport";"Activation of AMPK downstream of NMDARs";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Kinesins";"Resolution of Sister Chromatid Cohesion";"EML4 and NUDC in mitotic spindle formation";"Recruitment of NuMA to mitotic centrosomes";"HCMV Early Events";"Separation of Sister Chromatids";"COPI-dependent Golgi-to-ER retrograde traffic";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"RHO GTPases Activate Formins";"Recycling pathway of L1";"Carboxyterminal post-translational modifications of tubulin";"Assembly and cell surface presentation of NMDA receptors";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Mitotic Prometaphase";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Gap junction assembly";"Aggrephagy";"COPI-independent Golgi-to-ER retrograde traffic";"Cilium Assembly";"MHC class II antigen presentation"
XP_046417251.1	1	Reactome: R-HSA-5620922	"BBSome-mediated cargo-targeting to cilium"
XP_046431419.1	3	Reactome: R-HSA-392154;KEGG: 00230+4.6.1.2;Reactome: R-HSA-445355	"Nitric oxide stimulates guanylate cyclase";"Purine metabolism";"Smooth Muscle Contraction"
XP_046424813.1	13	Reactome: R-HSA-2871809;Reactome: R-HSA-114508;Reactome: R-HSA-139853;Reactome: R-HSA-5607763;Reactome: R-HSA-5218921;Reactome: R-HSA-381676;Reactome: R-HSA-983695;Reactome: R-HSA-4086398;Reactome: R-HSA-112043;Reactome: R-HSA-422356;Reactome: R-HSA-5578775;Reactome: R-HSA-2029485;Reactome: R-HSA-1489509	"FCERI mediated Ca+2 mobilization";"Effects of PIP2 hydrolysis";"Elevation of cytosolic Ca2+ levels";"CLEC7A (Dectin-1) induces NFAT activation";"VEGFR2 mediated cell proliferation";"Glucagon-like Peptide-1 (GLP1) regulates insulin secretion";"Antigen activates B Cell Receptor (BCR) leading to generation of second messengers";"Ca2+ pathway";"PLC beta mediated events";"Regulation of insulin secretion";"Ion homeostasis";"Role of phospholipids in phagocytosis";"DAG and IP3 signaling"
XP_046411413.1	5	Reactome: R-HSA-196807;MetaCyc: PWY-7268;MetaCyc: PWY-5083;MetaCyc: PWY-7269;KEGG: 00760+2.7.1.23	"Nicotinate metabolism";"NAD/NADP-NADH/NADPH cytosolic interconversion (yeast)";"NAD/NADH phosphorylation and dephosphorylation";"NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast)";"Nicotinate and nicotinamide metabolism"
XP_046410746.1	4	Reactome: R-HSA-5576893;Reactome: R-HSA-419037;Reactome: R-HSA-5576892;Reactome: R-HSA-112308	"Phase 2 - plateau phase";"NCAM1 interactions";"Phase 0 - rapid depolarisation";"Presynaptic depolarization and calcium channel opening"
XP_046416809.1	2	Reactome: R-HSA-8949215;Reactome: R-HSA-8949664	"Mitochondrial calcium ion transport";"Processing of SMDT1"
XP_046436299.1	7	Reactome: R-HSA-380270;Reactome: R-HSA-2565942;Reactome: R-HSA-380320;Reactome: R-HSA-380259;Reactome: R-HSA-8854518;Reactome: R-HSA-380284;Reactome: R-HSA-5620912	"Recruitment of mitotic centrosome proteins and complexes";"Regulation of PLK1 Activity at G2/M Transition";"Recruitment of NuMA to mitotic centrosomes";"Loss of Nlp from mitotic centrosomes";"AURKA Activation by TPX2";"Loss of proteins required for interphase microtubule organization from the centrosome";"Anchoring of the basal body to the plasma membrane"
XP_046435453.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046424902.1	6	Reactome: R-HSA-380994;Reactome: R-HSA-429958;Reactome: R-HSA-450513;Reactome: R-HSA-450604;Reactome: R-HSA-450385;Reactome: R-HSA-6791226	"ATF4 activates genes in response to endoplasmic reticulum stress";"mRNA decay by 3' to 5' exoribonuclease";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"KSRP (KHSRP) binds and destabilizes mRNA";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046413243.1	4	Reactome: R-HSA-186763;Reactome: R-HSA-373753;Reactome: R-HSA-4420097;Reactome: R-HSA-428540	"Downstream signal transduction";"Nephrin family interactions";"VEGFA-VEGFR2 Pathway";"Activation of RAC1"
XP_046413882.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_046416501.1	2	KEGG: 00670+2.1.2.10;KEGG: 00260+2.1.2.10	"One carbon pool by folate";"Glycine, serine and threonine metabolism"
XP_046432513.1	3	KEGG: 00860+1.16.3.1;Reactome: R-HSA-1268020;Reactome: R-HSA-1362409	"Porphyrin and chlorophyll metabolism";"Mitochondrial protein import";"Mitochondrial iron-sulfur cluster biogenesis"
XP_046419407.1	2	Reactome: R-HSA-2514859;KEGG: 00900+2.5.1.58	"Inactivation, recovery and regulation of the phototransduction cascade";"Terpenoid backbone biosynthesis"
XP_046410785.1	6	Reactome: R-HSA-450513;Reactome: R-HSA-450604;Reactome: R-HSA-380994;Reactome: R-HSA-429958;Reactome: R-HSA-450385;Reactome: R-HSA-6791226	"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"KSRP (KHSRP) binds and destabilizes mRNA";"ATF4 activates genes in response to endoplasmic reticulum stress";"mRNA decay by 3' to 5' exoribonuclease";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046430411.1	27	Reactome: R-HSA-191859;Reactome: R-HSA-159230;Reactome: R-HSA-180746;Reactome: R-HSA-5578749;Reactome: R-HSA-4615885;Reactome: R-HSA-3301854;Reactome: R-HSA-5619107;Reactome: R-HSA-168276;Reactome: R-HSA-168333;Reactome: R-HSA-159227;Reactome: R-HSA-168271;Reactome: R-HSA-159236;Reactome: R-HSA-3108214;Reactome: R-HSA-168325;Reactome: R-HSA-1169408;Reactome: R-HSA-159231;Reactome: R-HSA-9609690;Reactome: R-HSA-9610379;Reactome: R-HSA-4570464;Reactome: R-HSA-6784531;Reactome: R-HSA-4085377;Reactome: R-HSA-165054;Reactome: R-HSA-4551638;Reactome: R-HSA-3232142;Reactome: R-HSA-170822;Reactome: R-HSA-3371453;Reactome: R-HSA-180910	"snRNP Assembly";"Transport of the SLBP Dependant Mature mRNA";"Nuclear import of Rev protein";"Transcriptional regulation by small RNAs";"SUMOylation of DNA replication proteins";"Nuclear Pore Complex (NPC) Disassembly";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"NS1 Mediated Effects on Host Pathways";"NEP/NS2 Interacts with the Cellular Export Machinery";"Transport of the SLBP independent Mature mRNA";"Transport of Ribonucleoproteins into the Host Nucleus";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"SUMOylation of DNA damage response and repair proteins";"Viral Messenger RNA Synthesis";"ISG15 antiviral mechanism";"Transport of Mature mRNA Derived from an Intronless Transcript";"HCMV Early Events";"HCMV Late Events";"SUMOylation of RNA binding proteins";"tRNA processing in the nucleus";"SUMOylation of SUMOylation proteins";"Rev-mediated nuclear export of HIV RNA";"SUMOylation of chromatin organization proteins";"SUMOylation of ubiquitinylation proteins";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"Regulation of HSF1-mediated heat shock response";"Vpr-mediated nuclear import of PICs"
XP_046413924.1	4	Reactome: R-HSA-5696394;Reactome: R-HSA-8856825;Reactome: R-HSA-6781823;Reactome: R-HSA-8951664	"DNA Damage Recognition in GG-NER";"Cargo recognition for clathrin-mediated endocytosis";"Formation of TC-NER Pre-Incision Complex";"Neddylation"
XP_046430672.1	1	Reactome: R-HSA-5635838	"Activation of SMO"
XP_046427571.1	5	Reactome: R-HSA-983712;Reactome: R-HSA-77387;Reactome: R-HSA-1222556;Reactome: R-HSA-917977;Reactome: R-HSA-9639288	"Ion channel transport";"Insulin receptor recycling";"ROS and RNS production in phagocytes";"Transferrin endocytosis and recycling";"Amino acids regulate mTORC1"
XP_046426128.1	1	Reactome: R-HSA-2129379	"Molecules associated with elastic fibres"
XP_046432807.1	2	Reactome: R-HSA-381340;Reactome: R-HSA-1989781	"Transcriptional regulation of white adipocyte differentiation";"PPARA activates gene expression"
XP_046422126.1	17	MetaCyc: PWY-6608;MetaCyc: PWY-6644;Reactome: R-HSA-6798695;MetaCyc: PWY-6620;Reactome: R-HSA-74259;Reactome: R-HSA-74217;MetaCyc: PWY-6609;MetaCyc: PWY-6611;KEGG: 00760+2.4.2.1;MetaCyc: PWY-4202;KEGG: 00230+2.4.2.1;MetaCyc: PWY-7179-1;MetaCyc: PWY-7179;MetaCyc: PWY-5695;KEGG: 00240+2.4.2.1;MetaCyc: PWY-6627;MetaCyc: PWY-5532	"Guanosine nucleotides degradation III";"Fluoroacetate and fluorothreonine biosynthesis";"Neutrophil degranulation";"Guanine and guanosine salvage";"Purine catabolism";"Purine salvage";"Adenine and adenosine salvage III";"Adenine and adenosine salvage V";"Nicotinate and nicotinamide metabolism";"Arsenate detoxification I (mammalian)";"Purine metabolism";"Purine deoxyribonucleosides degradation II";"Purine deoxyribonucleosides degradation I";"Inosine 5'-phosphate degradation";"Pyrimidine metabolism";"Salinosporamide A biosynthesis";"Nucleoside and nucleotide degradation (archaea)"
XP_046416489.1	7	Reactome: R-HSA-5693607;MetaCyc: PWY-7511;Reactome: R-HSA-5693565;Reactome: R-HSA-983168;Reactome: R-HSA-69473;Reactome: R-HSA-5693571;Reactome: R-HSA-3108214	"Processing of DNA double-strand break ends";"Protein ubiquitination";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Antigen processing: Ubiquitination & Proteasome degradation";"G2/M DNA damage checkpoint";"Nonhomologous End-Joining (NHEJ)";"SUMOylation of DNA damage response and repair proteins"
XP_046425140.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_046418789.1	2	Reactome: R-HSA-6798695;Reactome: R-HSA-983168	"Neutrophil degranulation";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046426790.1	6	MetaCyc: PWY-4261;MetaCyc: PWY-6952;Reactome: R-HSA-1483166;KEGG: 00564+1.1.5.3;Reactome: R-HSA-163560;MetaCyc: PWY-6118	"Glycerol degradation I";"Glycerophosphodiester degradation";"Synthesis of PA";"Glycerophospholipid metabolism";"Triglyceride catabolism";"Glycerol-3-phosphate shuttle"
XP_046416654.1	6	Reactome: R-HSA-8951430;Reactome: R-HSA-4641265;Reactome: R-HSA-201722;Reactome: R-HSA-3769402;Reactome: R-HSA-4411364;Reactome: R-HSA-4086398	"RUNX3 regulates WNT signaling";"Repression of WNT target genes";"Formation of the beta-catenin:TCF transactivating complex";"Deactivation of the beta-catenin transactivating complex";"Binding of TCF/LEF:CTNNB1 to target gene promoters";"Ca2+ pathway"
XP_046434485.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046417184.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046411127.1	1	Reactome: R-HSA-420029	"Tight junction interactions"
XP_046421664.1	2	Reactome: R-HSA-3299685;MetaCyc: PWY-6854	"Detoxification of Reactive Oxygen Species";"Ethylene biosynthesis III (microbes)"
XP_046431130.1	2	Reactome: R-HSA-390522;Reactome: R-HSA-445355	"Striated Muscle Contraction";"Smooth Muscle Contraction"
XP_046428503.1	5	MetaCyc: PWY-3341;Reactome: R-HSA-8964539;MetaCyc: PWY-6344;MetaCyc: PWY-4981;KEGG: 00330+1.5.1.2	"L-proline biosynthesis III (from L-ornithine)";"Glutamate and glutamine metabolism";"L-ornithine degradation II (Stickland reaction)";"L-proline biosynthesis II (from arginine)";"Arginine and proline metabolism"
XP_046431684.1	6	Reactome: R-HSA-141444;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813;Reactome: R-HSA-68877;Reactome: R-HSA-2500257;Reactome: R-HSA-5663220	"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids";"Mitotic Prometaphase";"Resolution of Sister Chromatid Cohesion";"RHO GTPases Activate Formins"
XP_046435065.1	1	Reactome: R-HSA-426486	"Small interfering RNA (siRNA) biogenesis"
XP_046420729.1	1	Reactome: R-HSA-3214858	"RMTs methylate histone arginines"
XP_046428324.1	3	MetaCyc: PWY-7892;Reactome: R-HSA-6787450;MetaCyc: PWY-7887	"Trna-uridine 2-thiolation and selenation (bacteria)";"tRNA modification in the mitochondrion";"Protein SAMPylation and SAMP-mediated thiolation"
XP_046426603.1	3	Reactome: R-HSA-76061;Reactome: R-HSA-76066;Reactome: R-HSA-749476	"RNA Polymerase III Transcription Initiation From Type 1 Promoter";"RNA Polymerase III Transcription Initiation From Type 2 Promoter";"RNA Polymerase III Abortive And Retractive Initiation"
XP_046419410.1	7	Reactome: R-HSA-77111;Reactome: R-HSA-9033241;MetaCyc: PWY-5074;KEGG: 00072+4.1.3.4;KEGG: 00650+4.1.3.4;KEGG: 00280+4.1.3.4;KEGG: 00281+4.1.3.4	"Synthesis of Ketone Bodies";"Peroxisomal protein import";"Mevalonate degradation";"Synthesis and degradation of ketone bodies";"Butanoate metabolism";"Valine, leucine and isoleucine degradation";"Geraniol degradation"
XP_046419514.1	3	Reactome: R-HSA-3000157;Reactome: R-HSA-8874081;Reactome: R-HSA-3000171	"Laminin interactions";"MET activates PTK2 signaling";"Non-integrin membrane-ECM interactions"
XP_046412052.1	3	Reactome: R-HSA-983189;Reactome: R-HSA-6811434;Reactome: R-HSA-390471	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic";"Association of TriC/CCT with target proteins during biosynthesis"
XP_046417902.1	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840	"Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation"
XP_046426008.1	1	Reactome: R-HSA-6791226	"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046418758.1	7	KEGG: 00230+2.4.2.7;MetaCyc: PWY-7807;Reactome: R-HSA-74217;MetaCyc: PWY-6610;MetaCyc: PWY-7805;MetaCyc: PWY-6605;Reactome: R-HSA-6798695	"Purine metabolism";"Glyphosate degradation III";"Purine salvage";"Adenine salvage";"(aminomethyl)phosphonate degradation";"Adenine and adenosine salvage II";"Neutrophil degranulation"
XP_046424826.1	2	Reactome: R-HSA-6798695;Reactome: R-HSA-6803157	"Neutrophil degranulation";"Antimicrobial peptides"
XP_046416789.1	5	KEGG: 00534+2.4.1.224+2.4.1.225;Reactome: R-HSA-3656253;Reactome: R-HSA-3656237;Reactome: R-HSA-2022928;MetaCyc: PWY-6558	"Glycosaminoglycan biosynthesis - heparan sulfate / heparin";"Defective EXT1 causes exostoses 1, TRPS2 and CHDS";"Defective EXT2 causes exostoses 2";"HS-GAG biosynthesis";"Heparan sulfate biosynthesis (late stages)"
XP_046413414.1	2	Reactome: R-HSA-5689603;Reactome: R-HSA-5696394	"UCH proteinases";"DNA Damage Recognition in GG-NER"
XP_046430189.1	2	Reactome: R-HSA-8951671;Reactome: R-HSA-2032785	"RUNX3 regulates YAP1-mediated transcription";"YAP1- and WWTR1 (TAZ)-stimulated gene expression"
XP_046424972.1	5	Reactome: R-HSA-427413;Reactome: R-HSA-73863;Reactome: R-HSA-73762;Reactome: R-HSA-73772;Reactome: R-HSA-5250924	"NoRC negatively regulates rRNA expression";"RNA Polymerase I Transcription Termination";"RNA Polymerase I Transcription Initiation";"RNA Polymerase I Promoter Escape";"B-WICH complex positively regulates rRNA expression"
XP_046417318.1	2	MetaCyc: PWY-7802;MetaCyc: PWY-7799	"N-end rule pathway II (prokaryotic)";"Arg/N-end rule pathway (eukaryotic)"
XP_046434256.1	3	Reactome: R-HSA-194840;Reactome: R-HSA-416482;Reactome: R-HSA-193648	"Rho GTPase cycle";"G alpha (12/13) signalling events";"NRAGE signals death through JNK"
XP_046417751.1	2	Reactome: R-HSA-5678895;Reactome: R-HSA-382556	"Defective CFTR causes cystic fibrosis";"ABC-family proteins mediated transport"
XP_046436191.1	1	Reactome: R-HSA-418594	"G alpha (i) signalling events"
XP_046427726.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_046415432.1	6	Reactome: R-HSA-181429;Reactome: R-HSA-210500;Reactome: R-HSA-212676;Reactome: R-HSA-388844;Reactome: R-HSA-264642;Reactome: R-HSA-181430	"Serotonin Neurotransmitter Release Cycle";"Glutamate Neurotransmitter Release Cycle";"Dopamine Neurotransmitter Release Cycle";"Receptor-type tyrosine-protein phosphatases";"Acetylcholine Neurotransmitter Release Cycle";"Norepinephrine Neurotransmitter Release Cycle"
XP_046431334.1	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
XP_046410792.1	4	Reactome: R-HSA-2408522;KEGG: 00970+6.1.1.10;KEGG: 00450+6.1.1.10;Reactome: R-HSA-379716	"Selenoamino acid metabolism";"Aminoacyl-tRNA biosynthesis";"Selenocompound metabolism";"Cytosolic tRNA aminoacylation"
XP_046416077.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046410859.1	4	Reactome: R-HSA-159236;Reactome: R-HSA-72187;Reactome: R-HSA-72163;Reactome: R-HSA-73856	"Transport of Mature mRNA derived from an Intron-Containing Transcript";"mRNA 3'-end processing";"mRNA Splicing - Major Pathway";"RNA Polymerase II Transcription Termination"
XP_046421490.1	1	Reactome: R-HSA-2299718	"Condensation of Prophase Chromosomes"
XP_046410712.1	1	Reactome: R-HSA-5620912	"Anchoring of the basal body to the plasma membrane"
XP_046415186.1	2	MetaCyc: PWY-7221;KEGG: 00230+2.7.4.8	"Guanosine ribonucleotides de novo biosynthesis";"Purine metabolism"
XP_046412043.1	4	Reactome: R-HSA-3000178;Reactome: R-HSA-3000170;Reactome: R-HSA-2129379;Reactome: R-HSA-216083	"ECM proteoglycans";"Syndecan interactions";"Molecules associated with elastic fibres";"Integrin cell surface interactions"
XP_046425988.1	1	Reactome: R-HSA-611105	"Respiratory electron transport"
XP_046422750.1	15	MetaCyc: PWY-7218;MetaCyc: PWY-6886;MetaCyc: PWY-6901;MetaCyc: PWY-2221;MetaCyc: PWY-8004;KEGG: 00010+2.7.1.40;MetaCyc: PWY-5723;MetaCyc: PWY-6142;MetaCyc: PWY-7383;MetaCyc: PWY-1042;MetaCyc: PWY-5484;KEGG: 00230+2.7.1.40;KEGG: 00620+2.7.1.40;Reactome: R-HSA-70171;MetaCyc: PWY-7003	"Photosynthetic 3-hydroxybutanoate biosynthesis (engineered)";"1-butanol autotrophic biosynthesis (engineered)";"Superpathway of glucose and xylose degradation";"Entner-Doudoroff pathway III (semi-phosphorylative)";"Entner-Doudoroff pathway I";"Glycolysis / Gluconeogenesis";"Rubisco shunt";"Gluconeogenesis II (Methanobacterium thermoautotrophicum)";"Anaerobic energy metabolism (invertebrates, cytosol)";"Glycolysis IV (plant cytosol)";"Glycolysis II (from fructose 6-phosphate)";"Purine metabolism";"Pyruvate metabolism";"Glycolysis";"Glycerol degradation to butanol"
XP_046424240.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046422515.1	6	Reactome: R-HSA-141444;Reactome: R-HSA-9648025;Reactome: R-HSA-2467813;Reactome: R-HSA-68877;Reactome: R-HSA-2500257;Reactome: R-HSA-5663220	"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"EML4 and NUDC in mitotic spindle formation";"Separation of Sister Chromatids";"Mitotic Prometaphase";"Resolution of Sister Chromatid Cohesion";"RHO GTPases Activate Formins"
XP_046433129.1	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
XP_046429872.1	7	Reactome: R-HSA-156711;Reactome: R-HSA-1362300;Reactome: R-HSA-1362277;Reactome: R-HSA-69205;Reactome: R-HSA-69656;Reactome: R-HSA-69202;Reactome: R-HSA-1538133	"Polo-like kinase mediated events";"Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1";"Transcription of E2F targets under negative control by DREAM complex";"G1/S-Specific Transcription";"Cyclin A:Cdk2-associated events at S phase entry";"Cyclin E associated events during G1/S transition";"G0 and Early G1"
XP_046430156.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_046409883.1	2	Reactome: R-HSA-72163;Reactome: R-HSA-430039	"mRNA Splicing - Major Pathway";"mRNA decay by 5' to 3' exoribonuclease"
XP_046410649.1	1	Reactome: R-HSA-8949664	"Processing of SMDT1"
XP_046431795.1	3	Reactome: R-HSA-8856828;Reactome: R-HSA-8875656;Reactome: R-HSA-8854214	"Clathrin-mediated endocytosis";"MET receptor recycling";"TBC/RABGAPs"
XP_046412358.1	2	Reactome: R-HSA-5173214;Reactome: R-HSA-5083635	"O-glycosylation of TSR domain-containing proteins";"Defective B3GALTL causes Peters-plus syndrome (PpS)"
XP_046428456.1	18	Reactome: R-HSA-1482801;MetaCyc: PWY-7417;KEGG: 00565+3.1.1.4;Reactome: R-HSA-1482788;MetaCyc: PWY-8051;Reactome: R-HSA-1482922;KEGG: 00592+3.1.1.4;Reactome: R-HSA-1483166;KEGG: 00590+3.1.1.4;Reactome: R-HSA-1482839;MetaCyc: PWY-8053;MetaCyc: PWY-7416;MetaCyc: PWY-7409;KEGG: 00564+3.1.1.4;KEGG: 00591+3.1.1.4;Reactome: R-HSA-1482925;MetaCyc: PWY-6803;MetaCyc: PWY-7783	"Acyl chain remodelling of PS";"Phospholipid remodeling (phosphatidate, yeast)";"Ether lipid metabolism";"Acyl chain remodelling of PC";"Anandamide biosynthesis I";"Acyl chain remodelling of PI";"alpha-Linolenic acid metabolism";"Synthesis of PA";"Arachidonic acid metabolism";"Acyl chain remodelling of PE";"Anandamide biosynthesis II";"Phospholipid remodeling (phosphatidylcholine, yeast)";"Phospholipid remodeling (phosphatidylethanolamine, yeast)";"Glycerophospholipid metabolism";"Linoleic acid metabolism";"Acyl chain remodelling of PG";"Phosphatidylcholine acyl editing";"Plasmalogen degradation"
XP_046428551.1	1	Reactome: R-HSA-389957	"Prefoldin mediated transfer of substrate to CCT/TriC"
XP_046427798.1	58	Reactome: R-HSA-180585;Reactome: R-HSA-5678895;Reactome: R-HSA-5610785;Reactome: R-HSA-8939236;Reactome: R-HSA-174084;Reactome: R-HSA-8951664;Reactome: R-HSA-5689880;Reactome: R-HSA-349425;Reactome: R-HSA-1236978;Reactome: R-HSA-4608870;Reactome: R-HSA-4641257;Reactome: R-HSA-202424;Reactome: R-HSA-75815;Reactome: R-HSA-174154;Reactome: R-HSA-174184;Reactome: R-HSA-8939902;Reactome: R-HSA-2467813;Reactome: R-HSA-5607761;Reactome: R-HSA-983168;Reactome: R-HSA-5658442;Reactome: R-HSA-6798695;Reactome: R-HSA-5689603;Reactome: R-HSA-68827;Reactome: R-HSA-5607764;Reactome: R-HSA-187577;Reactome: R-HSA-180534;Reactome: R-HSA-1234176;Reactome: R-HSA-8948751;Reactome: R-HSA-69481;Reactome: R-HSA-8852276;Reactome: R-HSA-5610783;Reactome: R-HSA-9020702;Reactome: R-HSA-8854050;Reactome: R-HSA-174113;Reactome: R-HSA-5687128;Reactome: R-HSA-69017;Reactome: R-HSA-69601;Reactome: R-HSA-5358346;Reactome: R-HSA-5676590;Reactome: R-HSA-9604323;Reactome: R-HSA-5362768;Reactome: R-HSA-68949;Reactome: R-HSA-382556;Reactome: R-HSA-1169091;Reactome: R-HSA-2871837;Reactome: R-HSA-174178;Reactome: R-HSA-195253;Reactome: R-HSA-5689901;Reactome: R-HSA-1236974;Reactome: R-HSA-5610780;Reactome: R-HSA-450408;Reactome: R-HSA-5632684;Reactome: R-HSA-4641258;Reactome: R-HSA-211733;Reactome: R-HSA-5668541;Reactome: R-HSA-350562;Reactome: R-HSA-9010553;Reactome: R-HSA-8941858	"Vif-mediated degradation of APOBEC3G";"Defective CFTR causes cystic fibrosis";"GLI3 is processed to GLI3R by the proteasome";"RUNX1 regulates transcription of genes involved in differentiation of HSCs";"Autodegradation of Cdh1 by Cdh1:APC/C";"Neddylation";"Ub-specific processing proteases";"Autodegradation of the E3 ubiquitin ligase COP1";"Cross-presentation of soluble exogenous antigens (endosomes)";"Asymmetric localization of PCP proteins";"Degradation of AXIN";"Downstream TCR signaling";"Ubiquitin-dependent degradation of Cyclin D";"APC/C:Cdc20 mediated degradation of Securin";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Regulation of RUNX2 expression and activity";"Separation of Sister Chromatids";"Dectin-1 mediated noncanonical NF-kB signaling";"Antigen processing: Ubiquitination & Proteasome degradation";"Regulation of RAS by GAPs";"Neutrophil degranulation";"UCH proteinases";"CDT1 association with the CDC6:ORC:origin complex";"CLEC7A (Dectin-1) signaling";"SCF(Skp2)-mediated degradation of p27/p21";"Vpu mediated degradation of CD4";"Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha";"Regulation of PTEN stability and activity";"G2/M Checkpoints";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Degradation of GLI2 by the proteasome";"Interleukin-1 signaling";"FBXL7 down-regulates AURKA during mitotic entry and in early mitosis";"SCF-beta-TrCP mediated degradation of Emi1";"MAPK6/MAPK4 signaling";"CDK-mediated phosphorylation and removal of Cdc6";"Ubiquitin Mediated Degradation of Phosphorylated Cdc25A";"Hedgehog ligand biogenesis";"NIK-->noncanonical NF-kB signaling";"Negative regulation of NOTCH4 signaling";"Hh mutants that don't undergo autocatalytic processing are degraded by ERAD";"Orc1 removal from chromatin";"ABC-family proteins mediated transport";"Activation of NF-kappaB in B cells";"FCERI mediated NF-kB activation";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Degradation of beta-catenin by the destruction complex";"Metalloprotease DUBs";"ER-Phagosome pathway";"Degradation of GLI1 by the proteasome";"AUF1 (hnRNP D0) binds and destabilizes mRNA";"Hedgehog 'on' state";"Degradation of DVL";"Regulation of activated PAK-2p34 by proteasome mediated degradation";"TNFR2 non-canonical NF-kB pathway";"Regulation of ornithine decarboxylase (ODC)";"Regulation of expression of SLITs and ROBOs";"Regulation of RUNX3 expression and activity"
XP_046412859.1	3	MetaCyc: PWY-6558;Reactome: R-HSA-2022928;KEGG: 00534+5.1.3.17	"Heparan sulfate biosynthesis (late stages)";"HS-GAG biosynthesis";"Glycosaminoglycan biosynthesis - heparan sulfate / heparin"
XP_046434047.1	1	Reactome: R-HSA-1296061	"HCN channels"
XP_046433550.1	2	Reactome: R-HSA-983189;Reactome: R-HSA-6811434	"Kinesins";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_046416566.1	6	Reactome: R-HSA-5685939;Reactome: R-HSA-110362;Reactome: R-HSA-174437;Reactome: R-HSA-162594;Reactome: R-HSA-69166;Reactome: R-HSA-5651801	"HDR through MMEJ (alt-NHEJ)";"POLB-Dependent Long Patch Base Excision Repair";"Removal of the Flap Intermediate from the C-strand";"Early Phase of HIV Life Cycle";"Removal of the Flap Intermediate";"PCNA-Dependent Long Patch Base Excision Repair"
XP_046419567.1	7	Reactome: R-HSA-2894862;Reactome: R-HSA-2122948;Reactome: R-HSA-2644606;Reactome: R-HSA-9013507;Reactome: R-HSA-2979096;Reactome: R-HSA-2691232;MetaCyc: PWY-7511	"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Activated NOTCH1 Transmits Signal to the Nucleus";"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"NOTCH2 Activation and Transmission of Signal to the Nucleus";"Constitutive Signaling by NOTCH1 HD Domain Mutants";"Protein ubiquitination"
XP_046423266.1	17	MetaCyc: PWY-5744;KEGG: 00254+6.4.1.2;MetaCyc: PWY-6722;Reactome: R-HSA-163765;KEGG: 00620+6.4.1.2;MetaCyc: PWY-5743;Reactome: R-HSA-2426168;KEGG: 00720+6.4.1.2;MetaCyc: PWY-6679;MetaCyc: PWY-5966-1;KEGG: 00640+6.4.1.2;Reactome: R-HSA-200425;Reactome: R-HSA-196780;MetaCyc: PWY-4381;Reactome: R-HSA-3371599;KEGG: 00061+6.4.1.2;MetaCyc: PWY-5789	"Glyoxylate assimilation";"Aflatoxin biosynthesis";"Candicidin biosynthesis";"ChREBP activates metabolic gene expression";"Pyruvate metabolism";"3-hydroxypropanoate cycle";"Activation of gene expression by SREBF (SREBP)";"Carbon fixation pathways in prokaryotes";"Jadomycin biosynthesis";"Fatty acid biosynthesis initiation (animals and fungi, cytoplasm)";"Propanoate metabolism";"Carnitine metabolism";"Biotin transport and metabolism";"Fatty acid biosynthesis initiation (bacteria and plants)";"Defective HLCS causes multiple carboxylase deficiency";"Fatty acid biosynthesis";"3-hydroxypropanoate/4-hydroxybutanate cycle"
XP_046428261.1	1	Reactome: R-HSA-420499	"Class C/3 (Metabotropic glutamate/pheromone receptors)"
XP_046412676.1	7	Reactome: R-HSA-380320;Reactome: R-HSA-2565942;Reactome: R-HSA-380270;Reactome: R-HSA-8854518;Reactome: R-HSA-380259;Reactome: R-HSA-380284;Reactome: R-HSA-5620912	"Recruitment of NuMA to mitotic centrosomes";"Regulation of PLK1 Activity at G2/M Transition";"Recruitment of mitotic centrosome proteins and complexes";"AURKA Activation by TPX2";"Loss of Nlp from mitotic centrosomes";"Loss of proteins required for interphase microtubule organization from the centrosome";"Anchoring of the basal body to the plasma membrane"
XP_046415755.1	7	KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1	"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Relaxin signaling pathway";"Thermogenesis";"Human cytomegalovirus infection";"mTOR signaling pathway";"PI3K-Akt signaling pathway"
XP_046431805.1	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5368286;Reactome: R-HSA-5389840	"Mitochondrial translation termination";"Mitochondrial translation initiation";"Mitochondrial translation elongation"
XP_046426318.1	2	Reactome: R-HSA-201722;Reactome: R-HSA-3769402	"Formation of the beta-catenin:TCF transactivating complex";"Deactivation of the beta-catenin transactivating complex"
XP_046413281.1	16	Reactome: R-HSA-2559585;Reactome: R-HSA-8948700;Reactome: R-HSA-5628897;Reactome: R-HSA-8943723;Reactome: R-HSA-1912408;Reactome: R-HSA-8986944;Reactome: R-HSA-8936459;Reactome: R-HSA-9018519;Reactome: R-HSA-4086398;Reactome: R-HSA-8934593;Reactome: R-HSA-426496;Reactome: R-HSA-9029569;Reactome: R-HSA-2559580;Reactome: R-HSA-8853884;Reactome: R-HSA-5687128;Reactome: R-HSA-9022692	"Oncogene Induced Senescence";"Competing endogenous RNAs (ceRNAs) regulate PTEN translation";"TP53 Regulates Metabolic Genes";"Regulation of PTEN mRNA translation";"Pre-NOTCH Transcription and Translation";"Transcriptional Regulation by MECP2";"RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function";"Estrogen-dependent gene expression";"Ca2+ pathway";"Regulation of RUNX1 Expression and Activity";"Post-transcriptional silencing by small RNAs";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Oxidative Stress Induced Senescence";"Transcriptional Regulation by VENTX";"MAPK6/MAPK4 signaling";"Regulation of MECP2 expression and activity"
XP_046421870.1	7	KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1	"Thermogenesis";"Human cytomegalovirus infection";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Relaxin signaling pathway";"mTOR signaling pathway";"PI3K-Akt signaling pathway"
XP_046425124.1	2	Reactome: R-HSA-446193;Reactome: R-HSA-5633231	"Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein";"Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)"
XP_046430454.1	16	Reactome: R-HSA-5693568;Reactome: R-HSA-2559586;Reactome: R-HSA-5693579;Reactome: R-HSA-5685942;Reactome: R-HSA-5693607;Reactome: R-HSA-5693548;Reactome: R-HSA-201722;Reactome: R-HSA-3214847;Reactome: R-HSA-5685938;Reactome: R-HSA-5693554;Reactome: R-HSA-5693565;Reactome: R-HSA-6804756;Reactome: R-HSA-5693571;Reactome: R-HSA-69473;Reactome: R-HSA-9018519;Reactome: R-HSA-5693616	"Resolution of D-loop Structures through Holliday Junction Intermediates";"DNA Damage/Telomere Stress Induced Senescence";"Homologous DNA Pairing and Strand Exchange";"HDR through Homologous Recombination (HRR)";"Processing of DNA double-strand break ends";"Sensing of DNA Double Strand Breaks";"Formation of the beta-catenin:TCF transactivating complex";"HATs acetylate histones";"HDR through Single Strand Annealing (SSA)";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks";"Regulation of TP53 Activity through Phosphorylation";"Nonhomologous End-Joining (NHEJ)";"G2/M DNA damage checkpoint";"Estrogen-dependent gene expression";"Presynaptic phase of homologous DNA pairing and strand exchange"
XP_046416853.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_046424479.1	6	MetaCyc: PWY-7782;MetaCyc: PWY-5884;Reactome: R-HSA-9640463;MetaCyc: PWY-6733;MetaCyc: PWY-7656;KEGG: 00073+1.2.1.84	"Plasmalogen biosynthesis";"Wax esters biosynthesis I";"Wax biosynthesis";"Sporopollenin precursors biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Cutin, suberine and wax biosynthesis"
XP_046428081.1	12	MetaCyc: PWY-6708;MetaCyc: PWY-5855;MetaCyc: PWY-5857;MetaCyc: PWY-7230;MetaCyc: PWY-7233;MetaCyc: PWY-5856;MetaCyc: PWY-5870;MetaCyc: PWY-5872;Reactome: R-HSA-2142789;MetaCyc: PWY-5873;MetaCyc: PWY-5871;KEGG: 00130+1.14.99.60	"Ubiquinol-8 biosynthesis (prokaryotic)";"Ubiquinol-7 biosynthesis (prokaryotic)";"Ubiquinol-10 biosynthesis (prokaryotic)";"Ubiquinol-6 biosynthesis from 4-aminobenzoate (yeast)";"Ubiquinol-6 bypass biosynthesis (eukaryotic)";"Ubiquinol-9 biosynthesis (prokaryotic)";"Ubiquinol-8 biosynthesis (eukaryotic)";"Ubiquinol-10 biosynthesis (eukaryotic)";"Ubiquinol biosynthesis";"Ubiquinol-7 biosynthesis (eukaryotic)";"Ubiquinol-9 biosynthesis (eukaryotic)";"Ubiquinone and other terpenoid-quinone biosynthesis"
XP_046435713.1	2	KEGG: 00970+6.3.5.7;Reactome: R-HSA-2142753	"Aminoacyl-tRNA biosynthesis";"Arachidonic acid metabolism"
XP_046429563.1	1	Reactome: R-HSA-3214841	"PKMTs methylate histone lysines"
XP_046434577.1	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046436279.1	6	KEGG: 00561+2.7.1.107;MetaCyc: PWY-7039;MetaCyc: PWY-7817;KEGG: 00564+2.7.1.107;Reactome: R-HSA-114508;KEGG: 04070+2.7.1.107	"Glycerolipid metabolism";"Phosphatidate metabolism, as a signaling molecule";"Type I lipoteichoic acid biosynthesis (S. aureus)";"Glycerophospholipid metabolism";"Effects of PIP2 hydrolysis";"Phosphatidylinositol signaling system"
XP_046426178.1	2	Reactome: R-HSA-9033241;Reactome: R-HSA-389661	"Peroxisomal protein import";"Glyoxylate metabolism and glycine degradation"
XP_046421266.1	4	Reactome: R-HSA-1362277;Reactome: R-HSA-69656;Reactome: R-HSA-69202;Reactome: R-HSA-8953750	"Transcription of E2F targets under negative control by DREAM complex";"Cyclin A:Cdk2-associated events at S phase entry";"Cyclin E associated events during G1/S transition";"Transcriptional Regulation by E2F6"
XP_046417301.1	2	MetaCyc: PWY-7799;MetaCyc: PWY-7802	"Arg/N-end rule pathway (eukaryotic)";"N-end rule pathway II (prokaryotic)"
XP_046424073.1	13	Reactome: R-HSA-192823;Reactome: R-HSA-9010553;Reactome: R-HSA-156827;Reactome: R-HSA-9633012;Reactome: R-HSA-72689;Reactome: R-HSA-1799339;Reactome: R-HSA-2408557;Reactome: R-HSA-72706;Reactome: R-HSA-6791226;Reactome: R-HSA-975957;Reactome: R-HSA-72764;Reactome: R-HSA-975956;Reactome: R-HSA-156902	"Viral mRNA Translation";"Regulation of expression of SLITs and ROBOs";"L13a-mediated translational silencing of Ceruloplasmin expression";"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Formation of a pool of free 40S subunits";"SRP-dependent cotranslational protein targeting to membrane";"Selenocysteine synthesis";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Major pathway of rRNA processing in the nucleolus and cytosol";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Peptide chain elongation"
XP_046416517.1	27	Reactome: R-HSA-180910;Reactome: R-HSA-3371453;Reactome: R-HSA-170822;Reactome: R-HSA-3232142;Reactome: R-HSA-4551638;Reactome: R-HSA-6784531;Reactome: R-HSA-4085377;Reactome: R-HSA-165054;Reactome: R-HSA-4570464;Reactome: R-HSA-9610379;Reactome: R-HSA-9609690;Reactome: R-HSA-168325;Reactome: R-HSA-1169408;Reactome: R-HSA-159231;Reactome: R-HSA-3108214;Reactome: R-HSA-159236;Reactome: R-HSA-168271;Reactome: R-HSA-159227;Reactome: R-HSA-168333;Reactome: R-HSA-168276;Reactome: R-HSA-5619107;Reactome: R-HSA-3301854;Reactome: R-HSA-4615885;Reactome: R-HSA-5578749;Reactome: R-HSA-180746;Reactome: R-HSA-159230;Reactome: R-HSA-191859	"Vpr-mediated nuclear import of PICs";"Regulation of HSF1-mediated heat shock response";"Regulation of Glucokinase by Glucokinase Regulatory Protein";"SUMOylation of ubiquitinylation proteins";"SUMOylation of chromatin organization proteins";"tRNA processing in the nucleus";"SUMOylation of SUMOylation proteins";"Rev-mediated nuclear export of HIV RNA";"SUMOylation of RNA binding proteins";"HCMV Late Events";"HCMV Early Events";"Viral Messenger RNA Synthesis";"ISG15 antiviral mechanism";"Transport of Mature mRNA Derived from an Intronless Transcript";"SUMOylation of DNA damage response and repair proteins";"Transport of Mature mRNA derived from an Intron-Containing Transcript";"Transport of Ribonucleoproteins into the Host Nucleus";"Transport of the SLBP independent Mature mRNA";"NEP/NS2 Interacts with the Cellular Export Machinery";"NS1 Mediated Effects on Host Pathways";"Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)";"Nuclear Pore Complex (NPC) Disassembly";"SUMOylation of DNA replication proteins";"Transcriptional regulation by small RNAs";"Nuclear import of Rev protein";"Transport of the SLBP Dependant Mature mRNA";"snRNP Assembly"
XP_046410713.1	3	Reactome: R-HSA-416482;Reactome: R-HSA-194840;Reactome: R-HSA-193648	"G alpha (12/13) signalling events";"Rho GTPase cycle";"NRAGE signals death through JNK"
XP_046421633.1	3	KEGG: 04070+2.7.4.24+2.7.4.21;MetaCyc: PWY-6369;Reactome: R-HSA-1855167	"Phosphatidylinositol signaling system";"Inositol diphosphates biosynthesis";"Synthesis of pyrophosphates in the cytosol"
XP_046415995.1	4	MetaCyc: PWY-7174;Reactome: R-HSA-1237112;MetaCyc: PWY-4361;KEGG: 00270+5.3.1.23	"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation II";"Methionine salvage pathway";"S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I";"Cysteine and methionine metabolism"
XP_046410557.1	2	Reactome: R-HSA-72163;Reactome: R-HSA-72165	"mRNA Splicing - Major Pathway";"mRNA Splicing - Minor Pathway"
XP_046418161.1	1	Reactome: R-HSA-975957	"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"
XP_046431960.1	1	Reactome: R-HSA-5669034	"TNFs bind their physiological receptors"
XP_046432611.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_046418873.1	1	Reactome: R-HSA-2393930	"Phosphate bond hydrolysis by NUDT proteins"
XP_046414620.1	7	MetaCyc: PWY-7158;MetaCyc: PWY-6134;KEGG: 00400+1.14.16.1;Reactome: R-HSA-2160456;KEGG: 00790+1.14.16.1;Reactome: R-HSA-8964208;KEGG: 00360+1.14.16.1	"L-phenylalanine degradation V";"L-tyrosine biosynthesis IV";"Phenylalanine, tyrosine and tryptophan biosynthesis";"Phenylketonuria";"Folate biosynthesis";"Phenylalanine metabolism";"Phenylalanine metabolism"
XP_046410016.1	2	Reactome: R-HSA-2132295;Reactome: R-HSA-877300	"MHC class II antigen presentation";"Interferon gamma signaling"
XP_046435952.1	2	Reactome: R-HSA-917729;Reactome: R-HSA-9610379	"Endosomal Sorting Complex Required For Transport (ESCRT)";"HCMV Late Events"
XP_046418272.1	7	Reactome: R-HSA-5663220;Reactome: R-HSA-2500257;Reactome: R-HSA-68877;Reactome: R-HSA-2467813;Reactome: R-HSA-9648025;Reactome: R-HSA-5626467;Reactome: R-HSA-141444	"RHO GTPases Activate Formins";"Resolution of Sister Chromatid Cohesion";"Mitotic Prometaphase";"Separation of Sister Chromatids";"EML4 and NUDC in mitotic spindle formation";"RHO GTPases activate IQGAPs";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"
XP_046425833.1	1	Reactome: R-HSA-196836	"Vitamin C (ascorbate) metabolism"
XP_046435782.1	12	Reactome: R-HSA-2565942;Reactome: R-HSA-380320;Reactome: R-HSA-380259;Reactome: R-HSA-6811436;Reactome: R-HSA-381038;Reactome: R-HSA-380284;Reactome: R-HSA-2132295;Reactome: R-HSA-380270;Reactome: R-HSA-3371497;Reactome: R-HSA-6807878;Reactome: R-HSA-8854518;Reactome: R-HSA-5620912	"Regulation of PLK1 Activity at G2/M Transition";"Recruitment of NuMA to mitotic centrosomes";"Loss of Nlp from mitotic centrosomes";"COPI-independent Golgi-to-ER retrograde traffic";"XBP1(S) activates chaperone genes";"Loss of proteins required for interphase microtubule organization from the centrosome";"MHC class II antigen presentation";"Recruitment of mitotic centrosome proteins and complexes";"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"COPI-mediated anterograde transport";"AURKA Activation by TPX2";"Anchoring of the basal body to the plasma membrane"
XP_046423330.1	2	Reactome: R-HSA-983231;Reactome: R-HSA-8949215	"Factors involved in megakaryocyte development and platelet production";"Mitochondrial calcium ion transport"
XP_046434591.1	22	Reactome: R-HSA-68877;Reactome: R-HSA-5675221;Reactome: R-HSA-432142;Reactome: R-HSA-5339716;Reactome: R-HSA-4641262;Reactome: R-HSA-196299;Reactome: R-HSA-5358749;Reactome: R-HSA-5663220;Reactome: R-HSA-5467348;Reactome: R-HSA-5467337;Reactome: R-HSA-9648025;Reactome: R-HSA-141444;Reactome: R-HSA-5358751;Reactome: R-HSA-2467813;Reactome: R-HSA-195253;Reactome: R-HSA-5358752;Reactome: R-HSA-6811558;Reactome: R-HSA-5467340;Reactome: R-HSA-5358747;Reactome: R-HSA-389513;Reactome: R-HSA-2500257;Reactome: R-HSA-5673000	"Mitotic Prometaphase";"Negative regulation of MAPK pathway";"Platelet sensitization by LDL";"Misspliced GSK3beta mutants stabilize beta-catenin";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"Beta-catenin phosphorylation cascade";"S37 mutants of beta-catenin aren't phosphorylated";"RHO GTPases Activate Formins";"Truncations of AMER1 destabilize the destruction complex";"APC truncation mutants have impaired AXIN binding";"EML4 and NUDC in mitotic spindle formation";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"S45 mutants of beta-catenin aren't phosphorylated";"Separation of Sister Chromatids";"Degradation of beta-catenin by the destruction complex";"T41 mutants of beta-catenin aren't phosphorylated";"PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling";"AXIN missense mutants destabilize the destruction complex";"S33 mutants of beta-catenin aren't phosphorylated";"CTLA4 inhibitory signaling";"Resolution of Sister Chromatid Cohesion";"RAF activation"
XP_046435914.1	1	Reactome: R-HSA-75105	"Fatty acyl-CoA biosynthesis"
XP_046418015.1	13	Reactome: R-HSA-9633012;Reactome: R-HSA-72689;Reactome: R-HSA-156827;Reactome: R-HSA-9010553;Reactome: R-HSA-192823;Reactome: R-HSA-72706;Reactome: R-HSA-2408557;Reactome: R-HSA-1799339;Reactome: R-HSA-975957;Reactome: R-HSA-6791226;Reactome: R-HSA-156902;Reactome: R-HSA-975956;Reactome: R-HSA-72764	"Response of EIF2AK4 (GCN2) to amino acid deficiency";"Formation of a pool of free 40S subunits";"L13a-mediated translational silencing of Ceruloplasmin expression";"Regulation of expression of SLITs and ROBOs";"Viral mRNA Translation";"GTP hydrolysis and joining of the 60S ribosomal subunit";"Selenocysteine synthesis";"SRP-dependent cotranslational protein targeting to membrane";"Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)";"Major pathway of rRNA processing in the nucleolus and cytosol";"Peptide chain elongation";"Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)";"Eukaryotic Translation Termination"
XP_046424871.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046410790.1	6	Reactome: R-HSA-6791226;Reactome: R-HSA-450385;Reactome: R-HSA-380994;Reactome: R-HSA-429958;Reactome: R-HSA-450604;Reactome: R-HSA-450513	"Major pathway of rRNA processing in the nucleolus and cytosol";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA";"ATF4 activates genes in response to endoplasmic reticulum stress";"mRNA decay by 3' to 5' exoribonuclease";"KSRP (KHSRP) binds and destabilizes mRNA";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA"
XP_046412500.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_046417253.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_046426028.1	1	Reactome: R-HSA-2564830	"Cytosolic iron-sulfur cluster assembly"
XP_046415377.1	1	Reactome: R-HSA-111957	"Cam-PDE 1 activation"
XP_046410075.1	13	Reactome: R-HSA-9014325;Reactome: R-HSA-2871837;Reactome: R-HSA-450302;Reactome: R-HSA-445989;Reactome: R-HSA-5357956;Reactome: R-HSA-937072;Reactome: R-HSA-5607764;Reactome: R-HSA-975163;Reactome: R-HSA-168638;Reactome: R-HSA-9020702;Reactome: R-HSA-9645460;Reactome: R-HSA-450321;Reactome: R-HSA-937042	"TICAM1,TRAF6-dependent induction of TAK1 complex";"FCERI mediated NF-kB activation";"activated TAK1 mediates p38 MAPK activation";"TAK1 activates NFkB by phosphorylation and activation of IKKs complex";"TNFR1-induced NFkappaB signaling pathway";"TRAF6-mediated induction of TAK1 complex within TLR4 complex";"CLEC7A (Dectin-1) signaling";"IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation";"NOD1/2 Signaling Pathway";"Interleukin-1 signaling";"Alpha-protein kinase 1 signaling pathway";"JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1";"IRAK2 mediated activation of TAK1 complex"
XP_046419612.1	1	Reactome: R-HSA-3214858	"RMTs methylate histone arginines"
XP_046417220.1	24	Reactome: R-HSA-3371497;Reactome: R-HSA-5663220;Reactome: R-HSA-437239;Reactome: R-HSA-8955332;Reactome: R-HSA-9609736;Reactome: R-HSA-8852276;Reactome: R-HSA-68877;Reactome: R-HSA-190840;Reactome: R-HSA-9646399;Reactome: R-HSA-6811436;Reactome: R-HSA-190861;Reactome: R-HSA-5617833;Reactome: R-HSA-2132295;Reactome: R-HSA-5626467;Reactome: R-HSA-6807878;Reactome: R-HSA-9619483;Reactome: R-HSA-1445148;Reactome: R-HSA-983189;Reactome: R-HSA-2500257;Reactome: R-HSA-9648025;Reactome: R-HSA-380320;Reactome: R-HSA-9609690;Reactome: R-HSA-2467813;Reactome: R-HSA-6811434	"HSP90 chaperone cycle for steroid hormone receptors (SHR)";"RHO GTPases Activate Formins";"Recycling pathway of L1";"Carboxyterminal post-translational modifications of tubulin";"Assembly and cell surface presentation of NMDA receptors";"The role of GTSE1 in G2/M progression after G2 checkpoint";"Mitotic Prometaphase";"Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane";"Aggrephagy";"COPI-independent Golgi-to-ER retrograde traffic";"Gap junction assembly";"Cilium Assembly";"MHC class II antigen presentation";"RHO GTPases activate IQGAPs";"COPI-mediated anterograde transport";"Activation of AMPK downstream of NMDARs";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Kinesins";"Resolution of Sister Chromatid Cohesion";"EML4 and NUDC in mitotic spindle formation";"Recruitment of NuMA to mitotic centrosomes";"HCMV Early Events";"Separation of Sister Chromatids";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_046429577.1	2	Reactome: R-HSA-1369007;Reactome: R-HSA-5683371	"Mitochondrial ABC transporters";"Defective ABCB6 causes isolated colobomatous microphthalmia 7 (MCOPCB7)"
XP_046425443.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046434456.1	1	Reactome: R-HSA-383280	"Nuclear Receptor transcription pathway"
XP_046412196.1	1	Reactome: R-HSA-8949613	"Cristae formation"
XP_046430950.1	8	KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 04926+2.7.11.1;Reactome: R-HSA-428540;KEGG: 05163+2.7.11.1	"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Thermogenesis";"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Relaxin signaling pathway";"Activation of RAC1";"Human cytomegalovirus infection"
XP_046434913.1	5	Reactome: R-HSA-6798695;Reactome: R-HSA-2029482;Reactome: R-HSA-5663213;Reactome: R-HSA-3928662;Reactome: R-HSA-8856828	"Neutrophil degranulation";"Regulation of actin dynamics for phagocytic cup formation";"RHO GTPases Activate WASPs and WAVEs";"EPHB-mediated forward signaling";"Clathrin-mediated endocytosis"
XP_046411686.1	1	Reactome: R-HSA-1296072	"Voltage gated Potassium channels"
XP_046410550.1	6	Reactome: R-HSA-429958;Reactome: R-HSA-380994;Reactome: R-HSA-450604;Reactome: R-HSA-450513;Reactome: R-HSA-6791226;Reactome: R-HSA-450385	"mRNA decay by 3' to 5' exoribonuclease";"ATF4 activates genes in response to endoplasmic reticulum stress";"KSRP (KHSRP) binds and destabilizes mRNA";"Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA";"Major pathway of rRNA processing in the nucleolus and cytosol";"Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA"
XP_046409753.1	1	Reactome: R-HSA-6803157	"Antimicrobial peptides"
XP_046424410.1	15	Reactome: R-HSA-174048;Reactome: R-HSA-69017;Reactome: R-HSA-174154;Reactome: R-HSA-176407;Reactome: R-HSA-176408;Reactome: R-HSA-174184;Reactome: R-HSA-176412;Reactome: R-HSA-2467813;Reactome: R-HSA-179409;Reactome: R-HSA-174178;Reactome: R-HSA-2559582;Reactome: R-HSA-141430;Reactome: R-HSA-174084;Reactome: R-HSA-176409;Reactome: R-HSA-8853884	"APC/C:Cdc20 mediated degradation of Cyclin B";"CDK-mediated phosphorylation and removal of Cdc6";"APC/C:Cdc20 mediated degradation of Securin";"Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase";"Regulation of APC/C activators between G1/S and early anaphase";"Cdc20:Phospho-APC/C mediated degradation of Cyclin A";"Phosphorylation of the APC/C";"Separation of Sister Chromatids";"APC-Cdc20 mediated degradation of Nek2A";"APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1";"Senescence-Associated Secretory Phenotype (SASP)";"Inactivation of APC/C via direct inhibition of the APC/C complex";"Autodegradation of Cdh1 by Cdh1:APC/C";"APC/C:Cdc20 mediated degradation of mitotic proteins";"Transcriptional Regulation by VENTX"
XP_046417978.1	1	Reactome: R-HSA-71384	"Ethanol oxidation"
XP_046415688.1	2	Reactome: R-HSA-6784531;Reactome: R-HSA-6791226	"tRNA processing in the nucleus";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046422657.1	4	Reactome: R-HSA-159236;Reactome: R-HSA-72187;Reactome: R-HSA-72163;Reactome: R-HSA-73856	"Transport of Mature mRNA derived from an Intron-Containing Transcript";"mRNA 3'-end processing";"mRNA Splicing - Major Pathway";"RNA Polymerase II Transcription Termination"
XP_046421822.1	1	KEGG: 00970+6.1.1.3	"Aminoacyl-tRNA biosynthesis"
XP_046416803.1	2	Reactome: R-HSA-8949664;Reactome: R-HSA-8949215	"Processing of SMDT1";"Mitochondrial calcium ion transport"
XP_046412591.1	1	Reactome: R-HSA-419771	"Opsins"
XP_046427790.1	10	MetaCyc: PWY-4061;MetaCyc: PWY-7112;KEGG: 00460+2.3.2.2;MetaCyc: PWY-4041;MetaCyc: PWY-8001;KEGG: 00430+2.3.2.2;MetaCyc: PWY-7559;KEGG: 00480+2.3.2.2+3.4.19.13;MetaCyc: PWY-5826;MetaCyc: PWY-6842	"Glutathione-mediated detoxification I";"4-hydroxy-2-nonenal detoxification";"Cyanoamino acid metabolism";"Gamma-glutamyl cycle";"Felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis";"Taurine and hypotaurine metabolism";"Glutathione degradation (DUG pathway";"Glutathione metabolism";"Hypoglycin biosynthesis";"Glutathione-mediated detoxification II"
XP_046409807.1	1	Reactome: R-HSA-425381	"Bicarbonate transporters"
XP_046430856.1	4	Reactome: R-HSA-499943;KEGG: 00230+2.7.4.8;Reactome: R-HSA-2161541;MetaCyc: PWY-7221	"Interconversion of nucleotide di- and triphosphates";"Purine metabolism";"Abacavir metabolism";"Guanosine ribonucleotides de novo biosynthesis"
XP_046420575.1	3	Reactome: R-HSA-418594;Reactome: R-HSA-416476;Reactome: R-HSA-375276	"G alpha (i) signalling events";"G alpha (q) signalling events";"Peptide ligand-binding receptors"
XP_046433843.1	1	Reactome: R-HSA-1474228	"Degradation of the extracellular matrix"
XP_046427793.1	10	MetaCyc: PWY-7559;KEGG: 00480+2.3.2.2+3.4.19.13;MetaCyc: PWY-5826;MetaCyc: PWY-6842;MetaCyc: PWY-7112;MetaCyc: PWY-4061;KEGG: 00460+2.3.2.2;MetaCyc: PWY-8001;MetaCyc: PWY-4041;KEGG: 00430+2.3.2.2	"Glutathione degradation (DUG pathway";"Glutathione metabolism";"Hypoglycin biosynthesis";"Glutathione-mediated detoxification II";"4-hydroxy-2-nonenal detoxification";"Glutathione-mediated detoxification I";"Cyanoamino acid metabolism";"Felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis";"Gamma-glutamyl cycle";"Taurine and hypotaurine metabolism"
XP_046426493.1	19	Reactome: R-HSA-8964041;Reactome: R-HSA-381426;Reactome: R-HSA-3000484;Reactome: R-HSA-3000497;Reactome: R-HSA-3000480;Reactome: R-HSA-8963888;Reactome: R-HSA-8866423;Reactome: R-HSA-202733;Reactome: R-HSA-5686938;Reactome: R-HSA-3000471;Reactome: R-HSA-8964046;Reactome: R-HSA-975634;Reactome: R-HSA-8856825;Reactome: R-HSA-8963901;Reactome: R-HSA-8964026;Reactome: R-HSA-8957275;Reactome: R-HSA-8964038;Reactome: R-HSA-8856828;Reactome: R-HSA-432142	"LDL remodeling";"Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)";"Scavenging by Class F Receptors";"Scavenging by Class H Receptors";"Scavenging by Class A Receptors";"Chylomicron assembly";"VLDL assembly";"Cell surface interactions at the vascular wall";"Regulation of TLR by endogenous ligand";"Scavenging by Class B Receptors";"VLDL clearance";"Retinoid metabolism and transport";"Cargo recognition for clathrin-mediated endocytosis";"Chylomicron remodeling";"Chylomicron clearance";"Post-translational protein phosphorylation";"LDL clearance";"Clathrin-mediated endocytosis";"Platelet sensitization by LDL"
XP_046429873.1	7	Reactome: R-HSA-69656;Reactome: R-HSA-1538133;Reactome: R-HSA-69202;Reactome: R-HSA-69205;Reactome: R-HSA-1362277;Reactome: R-HSA-1362300;Reactome: R-HSA-156711	"Cyclin A:Cdk2-associated events at S phase entry";"G0 and Early G1";"Cyclin E associated events during G1/S transition";"G1/S-Specific Transcription";"Transcription of E2F targets under negative control by DREAM complex";"Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1";"Polo-like kinase mediated events"
XP_046434496.1	2	Reactome: R-HSA-430039;MetaCyc: PWY-6938	"mRNA decay by 5' to 3' exoribonuclease";"NADH repair"
XP_046433083.1	3	Reactome: R-HSA-202427;Reactome: R-HSA-6807004;Reactome: R-HSA-6798695	"Phosphorylation of CD3 and TCR zeta chains";"Negative regulation of MET activity";"Neutrophil degranulation"
XP_046433665.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046432027.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_046416543.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046428430.1	7	KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1	"mTOR signaling pathway";"PI3K-Akt signaling pathway";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Relaxin signaling pathway";"Thermogenesis";"Human cytomegalovirus infection"
XP_046421226.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_046428354.1	1	Reactome: R-HSA-5389840	"Mitochondrial translation elongation"
XP_046416507.1	7	MetaCyc: PWY-6277;Reactome: R-HSA-73817;KEGG: 00250+2.4.2.14;MetaCyc: PWY-6122;MetaCyc: PWY-7282;MetaCyc: PWY-6121;KEGG: 00230+2.4.2.14	"Superpathway of 5-aminoimidazole ribonucleotide biosynthesis";"Purine ribonucleoside monophosphate biosynthesis";"Alanine, aspartate and glutamate metabolism";"5-aminoimidazole ribonucleotide biosynthesis II";"4-amino-2-methyl-5-phosphomethylpyrimidine biosynthesis";"5-aminoimidazole ribonucleotide biosynthesis I";"Purine metabolism"
XP_046421436.1	2	Reactome: R-HSA-5696394;Reactome: R-HSA-5689603	"DNA Damage Recognition in GG-NER";"UCH proteinases"
XP_046413229.1	1	Reactome: R-HSA-70221	"Glycogen breakdown (glycogenolysis)"
XP_046433128.1	2	Reactome: R-HSA-5083635;Reactome: R-HSA-5173214	"Defective B3GALTL causes Peters-plus syndrome (PpS)";"O-glycosylation of TSR domain-containing proteins"
XP_046417995.1	2	Reactome: R-HSA-6790901;Reactome: R-HSA-6791226	"rRNA modification in the nucleus and cytosol";"Major pathway of rRNA processing in the nucleolus and cytosol"
XP_046435402.1	4	Reactome: R-HSA-72187;Reactome: R-HSA-72163;Reactome: R-HSA-77595;Reactome: R-HSA-73856	"mRNA 3'-end processing";"mRNA Splicing - Major Pathway";"Processing of Intronless Pre-mRNAs";"RNA Polymerase II Transcription Termination"
XP_046428583.1	3	Reactome: R-HSA-194840;Reactome: R-HSA-416482;Reactome: R-HSA-193648	"Rho GTPase cycle";"G alpha (12/13) signalling events";"NRAGE signals death through JNK"
XP_046431991.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_046431343.1	2	MetaCyc: PWY-7936;KEGG: 00901+2.7.1.222	"Psilocybin biosynthesis";"Indole alkaloid biosynthesis"
XP_046427155.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_046420090.1	18	Reactome: R-HSA-167246;Reactome: R-HSA-6807505;Reactome: R-HSA-167238;Reactome: R-HSA-113418;Reactome: R-HSA-167287;Reactome: R-HSA-167158;Reactome: R-HSA-167160;Reactome: R-HSA-75955;Reactome: R-HSA-167243;Reactome: R-HSA-112382;Reactome: R-HSA-77075;Reactome: R-HSA-167200;Reactome: R-HSA-6796648;Reactome: R-HSA-72086;Reactome: R-HSA-674695;Reactome: R-HSA-167242;Reactome: R-HSA-167152;Reactome: R-HSA-167290	"Tat-mediated elongation of the HIV-1 transcript";"RNA polymerase II transcribes snRNA genes";"Pausing and recovery of Tat-mediated HIV elongation";"Formation of the Early Elongation Complex";"HIV elongation arrest and recovery";"Formation of the HIV-1 Early Elongation Complex";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"RNA Polymerase II Transcription Elongation";"Tat-mediated HIV elongation arrest and recovery";"Formation of RNA Pol II elongation complex";"RNA Pol II CTD phosphorylation and interaction with CE";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"TP53 Regulates Transcription of DNA Repair Genes";"mRNA Capping";"RNA Polymerase II Pre-transcription Events";"Abortive elongation of HIV-1 transcript in the absence of Tat";"Formation of HIV elongation complex in the absence of HIV Tat";"Pausing and recovery of HIV elongation"
XP_046427698.1	6	Reactome: R-HSA-9022537;Reactome: R-HSA-3214815;Reactome: R-HSA-1989781;Reactome: R-HSA-9029569;Reactome: R-HSA-9022692;Reactome: R-HSA-9609690	"Loss of MECP2 binding ability to the NCoR/SMRT complex";"HDACs deacetylate histones";"PPARA activates gene expression";"NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux";"Regulation of MECP2 expression and activity";"HCMV Early Events"
XP_046421057.1	4	Reactome: R-HSA-983189;Reactome: R-HSA-2132295;Reactome: R-HSA-5625970;Reactome: R-HSA-6811434	"Kinesins";"MHC class II antigen presentation";"RHO GTPases activate KTN1";"COPI-dependent Golgi-to-ER retrograde traffic"
XP_046424220.1	5	Reactome: R-HSA-1368108;KEGG: 00760+6.3.4.21;MetaCyc: PWY-5381;Reactome: R-HSA-6798695;Reactome: R-HSA-197264	"BMAL1:CLOCK,NPAS2 activates circadian gene expression";"Nicotinate and nicotinamide metabolism";"Pyridine nucleotide cycling (plants)";"Neutrophil degranulation";"Nicotinamide salvaging"
XP_046417826.1	3	Reactome: R-HSA-5368286;Reactome: R-HSA-5389840;Reactome: R-HSA-5419276	"Mitochondrial translation initiation";"Mitochondrial translation elongation";"Mitochondrial translation termination"
XP_046415330.1	1	Reactome: R-HSA-432722	"Golgi Associated Vesicle Biogenesis"
XP_046412809.1	1	Reactome: R-HSA-913709	"O-linked glycosylation of mucins"
XP_046428273.1	2	Reactome: R-HSA-983168;MetaCyc: PWY-7511	"Antigen processing: Ubiquitination & Proteasome degradation";"Protein ubiquitination"
XP_046421474.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_046417908.1	10	MetaCyc: PWY-6317;MetaCyc: PWY-3821;MetaCyc: PWY-6527;MetaCyc: PWY-7344;MetaCyc: PWY-7328;KEGG: 00052+5.1.3.2;Reactome: R-HSA-70370;KEGG: 00520+5.1.3.2;MetaCyc: PWY-6397;Reactome: R-HSA-5609977	"D-galactose degradation I (Leloir pathway)";"D-galactose detoxification";"Stachyose degradation";"UDP-alpha-D-galactose biosynthesis";"Superpathway of UDP-glucose-derived O-antigen building blocks biosynthesis";"Galactose metabolism";"Galactose catabolism";"Amino sugar and nucleotide sugar metabolism";"Mycolyl-arabinogalactan-peptidoglycan complex biosynthesis";"Defective GALE can cause Epimerase-deficiency galactosemia (EDG)"
XP_046425859.1	18	Reactome: R-HSA-8953750;Reactome: R-HSA-1221632;Reactome: R-HSA-5693554;MetaCyc: PWY-7511;Reactome: R-HSA-5685938;Reactome: R-HSA-5693568;Reactome: R-HSA-912446;Reactome: R-HSA-5693607;Reactome: R-HSA-5685942;Reactome: R-HSA-5693579;Reactome: R-HSA-69473;Reactome: R-HSA-5693571;Reactome: R-HSA-6804756;Reactome: R-HSA-3108214;Reactome: R-HSA-5689901;Reactome: R-HSA-6796648;Reactome: R-HSA-5693616;Reactome: R-HSA-5693565	"Transcriptional Regulation by E2F6";"Meiotic synapsis";"Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)";"Protein ubiquitination";"HDR through Single Strand Annealing (SSA)";"Resolution of D-loop Structures through Holliday Junction Intermediates";"Meiotic recombination";"Processing of DNA double-strand break ends";"HDR through Homologous Recombination (HRR)";"Homologous DNA Pairing and Strand Exchange";"G2/M DNA damage checkpoint";"Nonhomologous End-Joining (NHEJ)";"Regulation of TP53 Activity through Phosphorylation";"SUMOylation of DNA damage response and repair proteins";"Metalloprotease DUBs";"TP53 Regulates Transcription of DNA Repair Genes";"Presynaptic phase of homologous DNA pairing and strand exchange";"Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"
XP_046417900.1	1	Reactome: R-HSA-6784531	"tRNA processing in the nucleus"
XP_046429726.1	5	KEGG: 00510+1.3.1.94;Reactome: R-HSA-446199;Reactome: R-HSA-193048;Reactome: R-HSA-4755579;MetaCyc: PWY-6129	"N-Glycan biosynthesis";"Synthesis of Dolichyl-phosphate";"Androgen biosynthesis";"Defective SRD5A3 causes SRD5A3-CDG (CDG-1q) and KHRZ";"Dolichol and dolichyl phosphate biosynthesis"
XP_046420195.1	1	Reactome: R-HSA-6807505	"RNA polymerase II transcribes snRNA genes"
XP_046412362.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046429006.1	6	Reactome: R-HSA-3322077;KEGG: 00500+2.4.1.18;MetaCyc: PWY-5067;Reactome: R-HSA-3878781;MetaCyc: PWY-622;MetaCyc: PWY-7900	"Glycogen synthesis";"Starch and sucrose metabolism";"Glycogen biosynthesis II (from UDP-D-Glucose)";"Glycogen storage disease type IV (GBE1)";"Starch biosynthesis";"Glycogen biosynthesis III (from alpha-maltose 1-phosphate)"
XP_046428315.1	2	Reactome: R-HSA-4641265;Reactome: R-HSA-5339700	"Repression of WNT target genes";"TCF7L2 mutants don't bind CTBP"
XP_046436506.1	2	Reactome: R-HSA-8853383;KEGG: 00511+3.2.1.24	"Lysosomal oligosaccharide catabolism";"Other glycan degradation"
XP_046427395.1	1	KEGG: 04660+2.7.10.2	"T cell receptor signaling pathway"
XP_046432667.1	2	Reactome: R-HSA-8964038;Reactome: R-HSA-6798695	"LDL clearance";"Neutrophil degranulation"
XP_046429825.1	8	KEGG: 00524+2.7.1.1;KEGG: 00052+2.7.1.1;KEGG: 00500+2.7.1.1;KEGG: 00521+2.7.1.1;KEGG: 00010+2.7.1.1;KEGG: 00051+2.7.1.1;KEGG: 00520+2.7.1.1;Reactome: R-HSA-70171	"Neomycin, kanamycin and gentamicin biosynthesis";"Galactose metabolism";"Starch and sucrose metabolism";"Streptomycin biosynthesis";"Glycolysis / Gluconeogenesis";"Fructose and mannose metabolism";"Amino sugar and nucleotide sugar metabolism";"Glycolysis"
XP_046424387.1	1	Reactome: R-HSA-9037629	"Lewis blood group biosynthesis"
XP_046436318.1	1	Reactome: R-HSA-8955332	"Carboxyterminal post-translational modifications of tubulin"
XP_046428424.1	7	KEGG: 04714+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 04151+2.7.11.1	"Thermogenesis";"Human cytomegalovirus infection";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection";"Relaxin signaling pathway";"mTOR signaling pathway";"PI3K-Akt signaling pathway"
XP_046427467.1	3	KEGG: 00250+3.5.1.1;Reactome: R-HSA-8963693;KEGG: 00460+3.5.1.1	"Alanine, aspartate and glutamate metabolism";"Aspartate and asparagine metabolism";"Cyanoamino acid metabolism"
XP_046430914.1	1	Reactome: R-HSA-983168	"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046420797.1	10	Reactome: R-HSA-163680;Reactome: R-HSA-200425;Reactome: R-HSA-6804756;Reactome: R-HSA-9613354;Reactome: R-HSA-5628897;Reactome: R-HSA-1632852;Reactome: R-HSA-1445148;Reactome: R-HSA-380972;Reactome: R-HSA-2151209;Reactome: R-HSA-9619483	"AMPK inhibits chREBP transcriptional activation activity";"Carnitine metabolism";"Regulation of TP53 Activity through Phosphorylation";"Lipophagy";"TP53 Regulates Metabolic Genes";"Macroautophagy";"Translocation of SLC2A4 (GLUT4) to the plasma membrane";"Energy dependent regulation of mTOR by LKB1-AMPK";"Activation of PPARGC1A (PGC-1alpha) by phosphorylation";"Activation of AMPK downstream of NMDARs"
XP_046434838.1	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
XP_046416274.1	1	Reactome: R-HSA-5576886	"Phase 4 - resting membrane potential"
XP_046431208.1	5	MetaCyc: PWY-7391;Reactome: R-HSA-191273;KEGG: 00900+2.7.4.2;Reactome: R-HSA-2426168;MetaCyc: PWY-922	"Isoprene biosynthesis II (engineered)";"Cholesterol biosynthesis";"Terpenoid backbone biosynthesis";"Activation of gene expression by SREBF (SREBP)";"Mevalonate pathway I"
XP_046418270.1	7	Reactome: R-HSA-9648025;Reactome: R-HSA-5626467;Reactome: R-HSA-141444;Reactome: R-HSA-68877;Reactome: R-HSA-2467813;Reactome: R-HSA-5663220;Reactome: R-HSA-2500257	"EML4 and NUDC in mitotic spindle formation";"RHO GTPases activate IQGAPs";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"Mitotic Prometaphase";"Separation of Sister Chromatids";"RHO GTPases Activate Formins";"Resolution of Sister Chromatid Cohesion"
XP_046418184.1	1	Reactome: R-HSA-3214858	"RMTs methylate histone arginines"
XP_046425382.1	2	Reactome: R-HSA-917729;Reactome: R-HSA-162588	"Endosomal Sorting Complex Required For Transport (ESCRT)";"Budding and maturation of HIV virion"
XP_046433934.1	5	Reactome: R-HSA-427413;Reactome: R-HSA-73863;Reactome: R-HSA-73762;Reactome: R-HSA-5250924;Reactome: R-HSA-73772	"NoRC negatively regulates rRNA expression";"RNA Polymerase I Transcription Termination";"RNA Polymerase I Transcription Initiation";"B-WICH complex positively regulates rRNA expression";"RNA Polymerase I Promoter Escape"
XP_046421989.1	2	Reactome: R-HSA-418457;Reactome: R-HSA-1296052	"cGMP effects";"Ca2+ activated K+ channels"
XP_046419642.1	1	Reactome: R-HSA-72163	"mRNA Splicing - Major Pathway"
XP_046423482.1	3	Reactome: R-HSA-5617472;Reactome: R-HSA-6804115;Reactome: R-HSA-429947	"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain";"Deadenylation of mRNA"
XP_046433953.1	1	Reactome: R-HSA-936837	"Ion transport by P-type ATPases"
XP_046433644.1	1	Reactome: R-HSA-162710	"Synthesis of glycosylphosphatidylinositol (GPI)"
XP_046416841.1	1	Reactome: R-HSA-373080	"Class B/2 (Secretin family receptors)"
XP_046413520.1	1	Reactome: R-HSA-983231	"Factors involved in megakaryocyte development and platelet production"
XP_046420448.1	7	Reactome: R-HSA-2644606;Reactome: R-HSA-9013507;Reactome: R-HSA-2122948;Reactome: R-HSA-2894862;Reactome: R-HSA-2691232;Reactome: R-HSA-2660826;Reactome: R-HSA-2979096	"Constitutive Signaling by NOTCH1 PEST Domain Mutants";"NOTCH3 Activation and Transmission of Signal to the Nucleus";"Activated NOTCH1 Transmits Signal to the Nucleus";"Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants";"Constitutive Signaling by NOTCH1 HD Domain Mutants";"Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant";"NOTCH2 Activation and Transmission of Signal to the Nucleus"
XP_046411487.1	2	Reactome: R-HSA-877312;Reactome: R-HSA-6807004	"Regulation of IFNG signaling";"Negative regulation of MET activity"
XP_046422129.1	4	MetaCyc: PWY-7383;MetaCyc: PWY-8040;MetaCyc: PWY-8072;KEGG: 00473+5.1.1.1	"Anaerobic energy metabolism (invertebrates, cytosol)";"Ansatrienin biosynthesis";"Alanine racemization";"D-Alanine metabolism"
XP_046436023.1	1	Reactome: R-HSA-2672351	"Stimuli-sensing channels"
XP_046421636.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046415351.1	6	Reactome: R-HSA-163560;KEGG: 05235+3.1.3.16;KEGG: 04660+3.1.3.16;Reactome: R-HSA-400253;KEGG: 04658+3.1.3.16;Reactome: R-HSA-2173788	"Triglyceride catabolism";"PD-L1 expression and PD-1 checkpoint pathway in cancer";"T cell receptor signaling pathway";"Circadian Clock";"Th1 and Th2 cell differentiation";"Downregulation of TGF-beta receptor signaling"
XP_046433767.1	1	Reactome: R-HSA-189085	"Digestion of dietary carbohydrate"
XP_046412464.1	4	Reactome: R-HSA-6798163;KEGG: 00260+1.2.1.8+1.1.99.1;MetaCyc: PWY-7494;MetaCyc: PWY-3722	"Choline catabolism";"Glycine, serine and threonine metabolism";"Choline degradation IV";"Glycine betaine biosynthesis II (Gram-positive bacteria)"
XP_046414593.1	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
XP_046410126.1	2	KEGG: 00051+2.7.1.105+3.1.3.46;Reactome: R-HSA-9634600	"Fructose and mannose metabolism";"Regulation of glycolysis by fructose 2,6-bisphosphate metabolism"
XP_046432964.1	1	Reactome: R-HSA-435368	"Zinc efflux and compartmentalization by the SLC30 family"
XP_046424186.1	12	Reactome: R-HSA-3322077;MetaCyc: PWY-7238;MetaCyc: PWY-7817;MetaCyc: PWY-7343;KEGG: 00520+2.7.7.9;KEGG: 00052+2.7.7.9;KEGG: 00040+2.7.7.9;MetaCyc: PWY-6527;Reactome: R-HSA-173599;KEGG: 00500+2.7.7.9;KEGG: 00561+2.7.7.9;MetaCyc: PWY-3801	"Glycogen synthesis";"Sucrose biosynthesis II";"Type I lipoteichoic acid biosynthesis (S. aureus)";"UDP-alpha-D-glucose biosynthesis I";"Amino sugar and nucleotide sugar metabolism";"Galactose metabolism";"Pentose and glucuronate interconversions";"Stachyose degradation";"Formation of the active cofactor, UDP-glucuronate";"Starch and sucrose metabolism";"Glycerolipid metabolism";"Sucrose degradation II (sucrose synthase)"
XP_046416989.1	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
XP_046432776.1	1	Reactome: R-HSA-1268020	"Mitochondrial protein import"
XP_046433588.1	2	Reactome: R-HSA-425397;Reactome: R-HSA-5619061	"Transport of vitamins, nucleosides, and related molecules";"Defective SLC33A1 causes spastic paraplegia 42 (SPG42)"
XP_046425349.1	1	Reactome: R-HSA-159236	"Transport of Mature mRNA derived from an Intron-Containing Transcript"
XP_046433381.1	40	Reactome: R-HSA-5601884;Reactome: R-HSA-167172;Reactome: R-HSA-6803529;Reactome: R-HSA-167152;Reactome: R-HSA-167290;Reactome: R-HSA-77075;Reactome: R-HSA-167200;Reactome: R-HSA-6796648;Reactome: R-HSA-167242;Reactome: R-HSA-674695;Reactome: R-HSA-167238;Reactome: R-HSA-72165;Reactome: R-HSA-167246;Reactome: R-HSA-75953;Reactome: R-HSA-167160;Reactome: R-HSA-6782135;Reactome: R-HSA-73779;Reactome: R-HSA-72163;Reactome: R-HSA-167243;Reactome: R-HSA-112382;Reactome: R-HSA-75955;Reactome: R-HSA-76042;Reactome: R-HSA-5617472;Reactome: R-HSA-72203;Reactome: R-HSA-9018519;Reactome: R-HSA-8851708;Reactome: R-HSA-167161;Reactome: R-HSA-168325;Reactome: R-HSA-73776;Reactome: R-HSA-72086;Reactome: R-HSA-203927;Reactome: R-HSA-6782210;Reactome: R-HSA-113418;Reactome: R-HSA-6807505;Reactome: R-HSA-167162;Reactome: R-HSA-6781823;Reactome: R-HSA-5578749;Reactome: R-HSA-167287;Reactome: R-HSA-167158;Reactome: R-HSA-6781827	"PIWI-interacting RNA (piRNA) biogenesis";"Transcription of the HIV genome";"FGFR2 alternative splicing";"Formation of HIV elongation complex in the absence of HIV Tat";"Pausing and recovery of HIV elongation";"RNA Pol II CTD phosphorylation and interaction with CE";"Formation of HIV-1 elongation complex containing HIV-1 Tat";"TP53 Regulates Transcription of DNA Repair Genes";"Abortive elongation of HIV-1 transcript in the absence of Tat";"RNA Polymerase II Pre-transcription Events";"Pausing and recovery of Tat-mediated HIV elongation";"mRNA Splicing - Minor Pathway";"Tat-mediated elongation of the HIV-1 transcript";"RNA Polymerase II Transcription Initiation";"RNA Pol II CTD phosphorylation and interaction with CE during HIV infection";"Dual incision in TC-NER";"RNA Polymerase II Transcription Pre-Initiation And Promoter Opening";"mRNA Splicing - Major Pathway";"Tat-mediated HIV elongation arrest and recovery";"Formation of RNA Pol II elongation complex";"RNA Polymerase II Transcription Elongation";"RNA Polymerase II Transcription Initiation And Promoter Clearance";"Activation of anterior HOX genes in hindbrain development during early embryogenesis";"Processing of Capped Intron-Containing Pre-mRNA";"Estrogen-dependent gene expression";"Signaling by FGFR2 IIIa TM";"HIV Transcription Initiation";"Viral Messenger RNA Synthesis";"RNA Polymerase II Promoter Escape";"mRNA Capping";"MicroRNA (miRNA) biogenesis";"Gap-filling DNA repair synthesis and ligation in TC-NER";"Formation of the Early Elongation Complex";"RNA polymerase II transcribes snRNA genes";"RNA Polymerase II HIV Promoter Escape";"Formation of TC-NER Pre-Incision Complex";"Transcriptional regulation by small RNAs";"HIV elongation arrest and recovery";"Formation of the HIV-1 Early Elongation Complex";"Transcription-Coupled Nucleotide Excision Repair (TC-NER)"
XP_046428730.1	1	Reactome: R-HSA-3214847	"HATs acetylate histones"
XP_046417410.1	2	Reactome: R-HSA-1268020;MetaCyc: PWY-7533	"Mitochondrial protein import";"Gliotoxin biosynthesis"
XP_046417385.1	14	Reactome: R-HSA-2500257;Reactome: R-HSA-9634638;Reactome: R-HSA-69273;Reactome: R-HSA-5663220;Reactome: R-HSA-5687128;Reactome: R-HSA-165054;Reactome: R-HSA-450520;Reactome: R-HSA-168333;Reactome: R-HSA-3769402;Reactome: R-HSA-2467813;Reactome: R-HSA-2173788;Reactome: R-HSA-68877;Reactome: R-HSA-141444;Reactome: R-HSA-9648025	"Resolution of Sister Chromatid Cohesion";"Estrogen-dependent nuclear events downstream of ESR-membrane signaling";"Cyclin A/B1/B2 associated events during G2/M transition";"RHO GTPases Activate Formins";"MAPK6/MAPK4 signaling";"Rev-mediated nuclear export of HIV RNA";"HuR (ELAVL1) binds and stabilizes mRNA";"NEP/NS2 Interacts with the Cellular Export Machinery";"Deactivation of the beta-catenin transactivating complex";"Separation of Sister Chromatids";"Downregulation of TGF-beta receptor signaling";"Mitotic Prometaphase";"Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal";"EML4 and NUDC in mitotic spindle formation"
XP_046412505.1	1	Reactome: R-HSA-156588	"Glucuronidation"
XP_046431290.1	1	Reactome: R-HSA-426117	"Cation-coupled Chloride cotransporters"
XP_046416073.1	1	Reactome: R-HSA-8876198	"RAB GEFs exchange GTP for GDP on RABs"
XP_046414968.1	1	Reactome: R-HSA-1369062	"ABC transporters in lipid homeostasis"
XP_046434281.1	3	Reactome: R-HSA-5419276;Reactome: R-HSA-5389840;Reactome: R-HSA-5368286	"Mitochondrial translation termination";"Mitochondrial translation elongation";"Mitochondrial translation initiation"
XP_046416952.1	1	Reactome: R-HSA-189200	"Cellular hexose transport"
XP_046429625.1	5	Reactome: R-HSA-166208;Reactome: R-HSA-3371571;Reactome: R-HSA-165159;Reactome: R-HSA-5674400;Reactome: R-HSA-198323	"mTORC1-mediated signalling";"HSF1-dependent transactivation";"mTOR signalling";"Constitutive Signaling by AKT1 E17K in Cancer";"AKT phosphorylates targets in the cytosol"
XP_046420229.1	15	Reactome: R-HSA-5467333;Reactome: R-HSA-5358751;Reactome: R-HSA-5358752;Reactome: R-HSA-195253;Reactome: R-HSA-3769402;Reactome: R-HSA-111465;Reactome: R-HSA-5358747;Reactome: R-HSA-5339716;Reactome: R-HSA-4641262;Reactome: R-HSA-5467340;Reactome: R-HSA-196299;Reactome: R-HSA-5689896;Reactome: R-HSA-5358749;Reactome: R-HSA-5467337;Reactome: R-HSA-5467348	"APC truncation mutants are not K63 polyubiquitinated";"S45 mutants of beta-catenin aren't phosphorylated";"T41 mutants of beta-catenin aren't phosphorylated";"Degradation of beta-catenin by the destruction complex";"Deactivation of the beta-catenin transactivating complex";"Apoptotic cleavage of cellular proteins";"S33 mutants of beta-catenin aren't phosphorylated";"Misspliced GSK3beta mutants stabilize beta-catenin";"Disassembly of the destruction complex and recruitment of AXIN to the membrane";"AXIN missense mutants destabilize the destruction complex";"Beta-catenin phosphorylation cascade";"Ovarian tumor domain proteases";"S37 mutants of beta-catenin aren't phosphorylated";"APC truncation mutants have impaired AXIN binding";"Truncations of AMER1 destabilize the destruction complex"
XP_046427973.1	2	Reactome: R-HSA-2151201;Reactome: R-HSA-1989781	"Transcriptional activation of mitochondrial biogenesis";"PPARA activates gene expression"
XP_046424996.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046418441.1	1	Reactome: R-HSA-3238698	"WNT ligand biogenesis and trafficking"
XP_046431911.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046414170.1	1	Reactome: R-HSA-5620924	"Intraflagellar transport"
XP_046410176.1	1	Reactome: R-HSA-211981	"Xenobiotics"
XP_046411839.1	9	KEGG: 00401+2.6.1.5;KEGG: 00950+2.6.1.5;KEGG: 00130+2.6.1.5;KEGG: 00270+2.6.1.5;KEGG: 00960+2.6.1.5;KEGG: 00400+2.6.1.5;Reactome: R-HSA-8963684;KEGG: 00350+2.6.1.5;KEGG: 00360+2.6.1.5	"Novobiocin biosynthesis";"Isoquinoline alkaloid biosynthesis";"Ubiquinone and other terpenoid-quinone biosynthesis";"Cysteine and methionine metabolism";"Tropane, piperidine and pyridine alkaloid biosynthesis";"Phenylalanine, tyrosine and tryptophan biosynthesis";"Tyrosine catabolism";"Tyrosine metabolism";"Phenylalanine metabolism"
XP_046420744.1	2	KEGG: 00280+1.3.8.4;Reactome: R-HSA-70895	"Valine, leucine and isoleucine degradation";"Branched-chain amino acid catabolism"
XP_046412040.1	4	Reactome: R-HSA-3928662;Reactome: R-HSA-8856828;Reactome: R-HSA-2029482;Reactome: R-HSA-5663213	"EPHB-mediated forward signaling";"Clathrin-mediated endocytosis";"Regulation of actin dynamics for phagocytic cup formation";"RHO GTPases Activate WASPs and WAVEs"
XP_046410950.1	2	Reactome: R-HSA-532668;KEGG: 00511+3.2.1.96	"N-glycan trimming in the ER and Calnexin/Calreticulin cycle";"Other glycan degradation"
XP_046431470.1	7	KEGG: 04151+2.7.11.1;KEGG: 04150+2.7.11.1;KEGG: 05163+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04926+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 05165+2.7.11.1	"PI3K-Akt signaling pathway";"mTOR signaling pathway";"Human cytomegalovirus infection";"Thermogenesis";"Relaxin signaling pathway";"Human immunodeficiency virus 1 infection";"Human papillomavirus infection"
XP_046416620.1	1	Reactome: R-HSA-6798163	"Choline catabolism"
XP_046423628.1	3	Reactome: R-HSA-2024096;Reactome: R-HSA-2206282;KEGG: 00531+3.2.1.50	"HS-GAG degradation";"MPS IIIB - Sanfilippo syndrome B";"Glycosaminoglycan degradation"
XP_046430394.1	2	Reactome: R-HSA-5610787;Reactome: R-HSA-5620924	"Hedgehog 'off' state";"Intraflagellar transport"
XP_046409769.1	12	Reactome: R-HSA-194840;KEGG: 05165+2.7.11.1;KEGG: 05170+2.7.11.1;KEGG: 04714+2.7.11.1;KEGG: 04151+2.7.11.1;Reactome: R-HSA-416482;KEGG: 04150+2.7.11.1;Reactome: R-HSA-418885;Reactome: R-HSA-416476;Reactome: R-HSA-193648;KEGG: 04926+2.7.11.1;KEGG: 05163+2.7.11.1	"Rho GTPase cycle";"Human papillomavirus infection";"Human immunodeficiency virus 1 infection";"Thermogenesis";"PI3K-Akt signaling pathway";"G alpha (12/13) signalling events";"mTOR signaling pathway";"DCC mediated attractive signaling";"G alpha (q) signalling events";"NRAGE signals death through JNK";"Relaxin signaling pathway";"Human cytomegalovirus infection"
XP_046409924.1	5	Reactome: R-HSA-389957;Reactome: R-HSA-389960;Reactome: R-HSA-390471;Reactome: R-HSA-390450;Reactome: R-HSA-6814122	"Prefoldin mediated transfer of substrate to CCT/TriC";"Formation of tubulin folding intermediates by CCT/TriC";"Association of TriC/CCT with target proteins during biosynthesis";"Folding of actin by CCT/TriC";"Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"
XP_046422072.1	2	Reactome: R-HSA-425393;Reactome: R-HSA-5223345	"Transport of inorganic cations/anions and amino acids/oligopeptides";"Miscellaneous transport and binding events"
XP_046413862.1	2	KEGG: 04070+2.7.11.13;Reactome: R-HSA-5625740	"Phosphatidylinositol signaling system";"RHO GTPases activate PKNs"
XP_046421255.1	1	Reactome: R-HSA-194840	"Rho GTPase cycle"
XP_046423227.1	1	Reactome: R-HSA-1362409	"Mitochondrial iron-sulfur cluster biogenesis"
XP_046420210.1	6	MetaCyc: PWY-5884;MetaCyc: PWY-7782;KEGG: 00073+1.2.1.84;MetaCyc: PWY-7656;Reactome: R-HSA-9640463;MetaCyc: PWY-6733	"Wax esters biosynthesis I";"Plasmalogen biosynthesis";"Cutin, suberine and wax biosynthesis";"Spodoptera littoralis pheromone biosynthesis";"Wax biosynthesis";"Sporopollenin precursors biosynthesis"
XP_046429358.1	1	MetaCyc: PWY-7511	"Protein ubiquitination"
XP_046415281.1	2	MetaCyc: PWY-7511;Reactome: R-HSA-983168	"Protein ubiquitination";"Antigen processing: Ubiquitination & Proteasome degradation"
XP_046419292.1	2	Reactome: R-HSA-8866423;Reactome: R-HSA-8963888	"VLDL assembly";"Chylomicron assembly"
XP_046431963.1	12	KEGG: 00230+2.7.1.25;MetaCyc: PWY-5278;KEGG: 00261+2.7.7.4;KEGG: 00230+2.7.7.4;MetaCyc: PWY-5340;Reactome: R-HSA-2408550;KEGG: 00920+2.7.1.25;KEGG: 00450+2.7.7.4;KEGG: 00920+2.7.7.4;MetaCyc: PWY-6932;MetaCyc: PWY-6683;Reactome: R-HSA-174362	"Purine metabolism";"Sulfite oxidation III";"Monobactam biosynthesis";"Purine metabolism";"Sulfate activation for sulfonation";"Metabolism of ingested H2SeO4 and H2SeO3 into H2Se";"Sulfur metabolism";"Selenocompound metabolism";"Sulfur metabolism";"Selenate reduction";"Assimilatory sulfate reduction III";"Transport and synthesis of PAPS"