<?xml version="1.0" encoding="UTF-8"?><protein-matches xmlns="http://www.ebi.ac.uk/interpro/resources/schemas/interproscan5" interproscan-version="5.54-87.0">
  <protein>
    <sequence md5="94d9e768d5136f78036c910877f76101">MSAAGTTPSNANGPLVPAPLFALPTLSFSVSQVATVCETLEESGDIERLARFLWSLPVAHPNIQELNQSEAVLRARAIVAFHSGHYRELYAILERHKFTKDSHGKLQAMWLEAHYQEAEKLRGRPLGPVDKYRVRKKFPLPRTIWDGEQKTHCFKERTRSLLREWYLQDPYPNPGKKRELAAATGLTPTQVGNWFKNRRQRDRAAAAKNRMQQQSGQGNGNARRTMSPGPGGSSSEDSDISLGGTSPPSPSSSPPPSHQPSPVPLGSLGPLPPPSLNFRFDPTQPHFRFNHTTAFKFPPTNFRFAPHSPQPNHPNMAGGGIFRFAESSPFQAVGPRGDPTSRLPDSLGLPPPRLHPHEGLLHPHPHPQHQLSEGISRISETSRLSDGGLSRLSDSLSEAHSPPLIPANLSATGPLRVAVPSPHTPSSRGSPPPRQPTPQGQSQGQGLIRVATPPLPNPRPQIHRPFSPA</sequence>
    <xref id="XP_029177337.1" name="XP_029177337.1 homeobox protein SIX3 isoform X4 [Nylanderia fulva]"/>
    <matches>
      <coils-match>
        <signature ac="Coil" name="Coil">
          <signature-library-release library="COILS" version="2.2.1"/>
        </signature>
        <model-ac>Coil</model-ac>
        <locations>
          <coils-location start="197" end="217">
            <location-fragments>
              <coils-location-fragment start="197" end="217" dc-status="CONTINUOUS"/>
            </location-fragments>
          </coils-location>
        </locations>
      </coils-match>
      <hmmer2-match evalue="4.9E-14" score="62.6">
        <signature ac="SM00389" name="HOX_1">
          <entry ac="IPR001356" desc="Homeobox domain" name="Homeobox_dom" type="DOMAIN">
            <go-xref category="MOLECULAR_FUNCTION" db="GO" id="GO:0003677" name="DNA binding"/>
            <pathway-xref db="MetaCyc" id="PWY-7735" name="echinomycin and triostin A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-2892247" name="POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation"/>
            <pathway-xref db="MetaCyc" id="PWY-8151" name="cholesterol degradation to androstenedione III (anaerobic)"/>
            <pathway-xref db="MetaCyc" id="PWY-7694" name="zwittermicin A biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7265" name="lampranthin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7382" name="lipoate biosynthesis and incorporation IV (yeast)"/>
            <pathway-xref db="MetaCyc" id="PWY-7053" name="docosahexaenoate biosynthesis I (lower eukaryotes)"/>
            <pathway-xref db="Reactome" id="R-RNO-6804759" name="Regulation of TP53 Activity through Association with Co-factors"/>
            <pathway-xref db="MetaCyc" id="PWY-8035" name="streptovaricin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7621" name="autoinducer CAI-1 biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-76071" name="RNA Polymerase III Transcription Initiation From Type 3 Promoter"/>
            <pathway-xref db="MetaCyc" id="PWY-7583" name="arachidonate biosynthesis II (bacteria)"/>
            <pathway-xref db="MetaCyc" id="PWY-7049" name="icosapentaenoate biosynthesis II (6-desaturase, mammals)"/>
            <pathway-xref db="MetaCyc" id="PWY-5994" name="palmitate biosynthesis I (type I fatty acid synthase)"/>
            <pathway-xref db="MetaCyc" id="PWY-7419" name="FR-900098 and FR-33289 antibiotics biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7818" name="type IV lipoteichoic acid biosynthesis (S. pneumoniae)"/>
            <pathway-xref db="MetaCyc" id="PWY-5139" name="pelargonidin conjugates biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7460" name="2-O-acetyl-3-O-trans-coutarate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-210746" name="Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells"/>
            <pathway-xref db="Reactome" id="R-HSA-9010553" name="Regulation of expression of SLITs and ROBOs"/>
            <pathway-xref db="MetaCyc" id="PWY-8047" name="bryostatin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7624" name="nystatin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7711" name="calonectrin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6397" name="mycolyl-arabinogalactan-peptidoglycan complex biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5477" name="gallotannin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-4551638" name="SUMOylation of chromatin organization proteins"/>
            <pathway-xref db="MetaCyc" id="PWY-8051" name="anandamide biosynthesis I"/>
            <pathway-xref db="MetaCyc" id="PWY-6948" name="sitosterol degradation to androstenedione"/>
            <pathway-xref db="MetaCyc" id="PWY-7601" name="arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)"/>
            <pathway-xref db="MetaCyc" id="PWY-7950" name="diadinoxanthin and fucoxanthin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7100" name="spinosyn A biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7930" name="pyoluteorin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7352" name="daunorubicin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6842" name="glutathione-mediated detoxification II"/>
            <pathway-xref db="Reactome" id="R-MMU-6804759" name="Regulation of TP53 Activity through Association with Co-factors"/>
            <pathway-xref db="MetaCyc" id="PWY-8243" name="colanic acid (Escherichia coli K12) biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7465" name="3,3'-thiodipropanoate degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7599" name="anditomin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9619665" name="EGR2 and SOX10-mediated initiation of Schwann cell myelination"/>
            <pathway-xref db="MetaCyc" id="PWY-7401" name="crotonate fermentation (to acetate and cyclohexane carboxylate)"/>
            <pathway-xref db="MetaCyc" id="PWY-7816" name="poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)"/>
            <pathway-xref db="Reactome" id="R-HSA-3214847" name="HATs acetylate histones"/>
            <pathway-xref db="MetaCyc" id="PWY-8045" name="cylindrospermopsin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6679" name="jadomycin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7983" name="pseudomonine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5400" name="amaranthin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-8939245" name="RUNX1 regulates transcription of genes involved in BCR signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-400511" name="Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)"/>
            <pathway-xref db="Reactome" id="R-HSA-8940973" name="RUNX2 regulates osteoblast differentiation"/>
            <pathway-xref db="MetaCyc" id="PWY-8231" name="Escherichia coli serotype O:127 O antigen biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7168" name="flavonol acylglucoside biosynthesis I - kaempferol derivatives"/>
            <pathway-xref db="MetaCyc" id="PWY-7719" name="CMP-diacetamido-8-epilegionaminic acid biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7690" name="holomycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-3214847" name="HATs acetylate histones"/>
            <pathway-xref db="MetaCyc" id="PWY-7817" name="type I lipoteichoic acid biosynthesis (S. aureus)"/>
            <pathway-xref db="MetaCyc" id="PWY-6322" name="phosphinothricin tripeptide biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5307" name="gentiodelphin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7714" name="harzianum A and trichodermin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5710" name="capsaicin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5660" name="taxol biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8116" name="ochratoxin A biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8036" name="chaxamycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-8866906" name="TFAP2 (AP-2) family regulates transcription of other transcription factors"/>
            <pathway-xref db="MetaCyc" id="PWY-5437" name="L-threonine degradation I"/>
            <pathway-xref db="MetaCyc" id="PWY-5987" name="sorgoleone biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7606" name="docosahexaenoate biosynthesis III (6-desaturase, mammals)"/>
            <pathway-xref db="MetaCyc" id="PWY-7474" name="avenacin A-2 biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-8941855" name="RUNX3 regulates CDKN1A transcription"/>
            <pathway-xref db="MetaCyc" id="PWY-7696" name="citreoisocoumarin and bikisocoumarin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8133" name="succinoglycan biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-76071" name="RNA Polymerase III Transcription Initiation From Type 3 Promoter"/>
            <pathway-xref db="MetaCyc" id="PWY-81" name="toluene degradation to benzoyl-CoA (anaerobic)"/>
            <pathway-xref db="MetaCyc" id="PWY-7532" name="acetylaszonalenin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-1660661" name="Sphingolipid de novo biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8040" name="ansatrienin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8272" name="Escherichia coli serotype O:49 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-2892245" name="POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation"/>
            <pathway-xref db="MetaCyc" id="PWY-6971" name="oleandomycin biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-8053" name="anandamide biosynthesis II"/>
            <pathway-xref db="MetaCyc" id="PWY-8049" name="pederin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6036" name="cardenolide glucosides biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-HSA-2559582" name="Senescence-Associated Secretory Phenotype (SASP)"/>
            <pathway-xref db="Reactome" id="R-MMU-4551638" name="SUMOylation of chromatin organization proteins"/>
            <pathway-xref db="MetaCyc" id="PWY-7172" name="flavonol acylglucoside biosynthesis III - quercetin derivatives"/>
            <pathway-xref db="MetaCyc" id="PWY-6314" name="plumbagin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7612" name="chaetoglobosin A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-5578768" name="Physiological factors"/>
            <pathway-xref db="MetaCyc" id="PWY-6373" name="acrylate degradation I"/>
            <pathway-xref db="MetaCyc" id="PWY-7671" name="saframycin A biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6032" name="digitoxigenin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7592" name="arachidonate biosynthesis III (6-desaturase, mammals)"/>
            <pathway-xref db="MetaCyc" id="PWY-7693" name="guadinomine B biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-452723" name="Transcriptional regulation of pluripotent stem cells"/>
            <pathway-xref db="MetaCyc" id="PWY-5129" name="sphingolipid biosynthesis (plants)"/>
            <pathway-xref db="MetaCyc" id="PWY-7473" name="avenacin A-1 biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7461" name="hydroxycinnamate sugar acid ester biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7727" name="docosahexaenoate biosynthesis IV (4-desaturase, mammals)"/>
            <pathway-xref db="MetaCyc" id="PWY-7716" name="penicillin G and penicillin V biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6749" name="CMP-legionaminate biosynthesis I"/>
            <pathway-xref db="MetaCyc" id="PWY-8166" name="emodin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6312" name="barbaloin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7653" name="griseofulvin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-1660661" name="Sphingolipid de novo biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-4551638" name="SUMOylation of chromatin organization proteins"/>
            <pathway-xref db="MetaCyc" id="PWY-8152" name="androstenedione degradation II (anaerobic)"/>
            <pathway-xref db="MetaCyc" id="PWY-5048" name="rosmarinic acid biosynthesis I"/>
            <pathway-xref db="MetaCyc" id="PWY-8012" name="mupirocin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-361" name="phenylpropanoid biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-8939902" name="Regulation of RUNX2 expression and activity"/>
            <pathway-xref db="MetaCyc" id="PWY-761" name="rhizobactin 1021 biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7475" name="des-methyl avenacin A-1 biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7989" name="acinetoferrin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6320" name="phaselate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-210744" name="Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells"/>
            <pathway-xref db="Reactome" id="R-HSA-76071" name="RNA Polymerase III Transcription Initiation From Type 3 Promoter"/>
            <pathway-xref db="MetaCyc" id="PWY-7673" name="fusarin C biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7677" name="rosamicin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-4801" name="aloesone biosynthesis I"/>
            <pathway-xref db="MetaCyc" id="PWY-6407" name="yersiniabactin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7171" name="flavonol acylglucoside biosynthesis II - isorhamnetin derivatives"/>
            <pathway-xref db="MetaCyc" id="PWY-8055" name="palmitoyl ethanolamide biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7261" name="anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)"/>
            <pathway-xref db="Reactome" id="R-HSA-210747" name="Regulation of gene expression in early pancreatic precursor cells"/>
            <pathway-xref db="MetaCyc" id="PWY-8042" name="acylceramide biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7585" name="docosahexaenoate biosynthesis II (bacteria)"/>
            <pathway-xref db="MetaCyc" id="PWY-7563" name="bassianin and desmethylbassianin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-5617472" name="Activation of anterior HOX genes in hindbrain development during early embryogenesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6672" name="cis-geranyl-CoA degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7695" name="aurofusarin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5984" name="rifamycin B biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6442" name="spermidine hydroxycinnamic acid conjugates biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6722" name="candicidin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5975" name="furaneol and mesifurane biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7450" name="anthocyanidin modification (Arabidopsis)"/>
            <pathway-xref db="MetaCyc" id="PWY-7045" name="mithramycin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5353" name="arachidonate biosynthesis I (6-desaturase, lower eukaryotes)"/>
            <pathway-xref db="MetaCyc" id="PWY-7354" name="aclacinomycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9018519" name="Estrogen-dependent gene expression"/>
            <pathway-xref db="Reactome" id="R-MMU-6807505" name="RNA polymerase II transcribes snRNA genes"/>
            <pathway-xref db="MetaCyc" id="PWY-7415" name="tylosin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-8939245" name="RUNX1 regulates transcription of genes involved in BCR signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-7679" name="anthocyanidin acylglucoside and acylsambubioside biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6946" name="cholesterol degradation to androstenedione II (cholesterol dehydrogenase)"/>
            <pathway-xref db="MetaCyc" id="PWY-7530" name="Escherichia coli serotype O:104 O antigen biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7702" name="sch210971 and sch210972 biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5268" name="salvianin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6958" name="icosapentaenoate biosynthesis I (lower eukaryotes)"/>
            <pathway-xref db="Reactome" id="R-DME-8941855" name="RUNX3 regulates CDKN1A transcription"/>
            <pathway-xref db="Reactome" id="R-MMU-9018519" name="Estrogen-dependent gene expression"/>
            <pathway-xref db="MetaCyc" id="PWY-6673" name="caffeoylglucarate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6799" name="fatty acid biosynthesis initiation (plant mitochondria)"/>
            <pathway-xref db="MetaCyc" id="PWY-5473" name="hydroxycinnamic acid serotonin amides biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7656" name="Spodoptera littoralis pheromone biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6453" name="stigma estolide biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-8853884" name="Transcriptional Regulation by VENTX"/>
            <pathway-xref db="MetaCyc" id="PWY-5875" name="staphyloxanthin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-4922" name="6-methoxymellein biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5475" name="pentagalloylglucose biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7692" name="bikaverin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6056" name="dimethylsulfoniopropanoate degradation II (cleavage)"/>
            <pathway-xref db="MetaCyc" id="PWY-7811" name="6-methylpretetramide biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-111465" name="Apoptotic cleavage of cellular proteins"/>
            <pathway-xref db="MetaCyc" id="PWY-8157" name="avenanthramide biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6316" name="aromatic polyketides biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7452" name="cyanidin dimalonylglucoside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-390193" name="Transcriptional activation by YKI"/>
            <pathway-xref db="MetaCyc" id="PWY-8082" name="glycine lipid biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5284" name="shisonin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7565" name="aspyridone A biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8032" name="chloramphenicol biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-6807505" name="RNA polymerase II transcribes snRNA genes"/>
            <pathway-xref db="MetaCyc" id="PWY-7050" name="icosapentaenoate biosynthesis IV (bacteria)"/>
            <pathway-xref db="MetaCyc" id="PWY-6920" name="6-gingerol analog biosynthesis (engineered)"/>
            <pathway-xref db="MetaCyc" id="PWY-7769" name="phosalacine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7688" name="dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWYG-321" name="mycolate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6378" name="putrebactin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8038" name="naphthomycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-2173796" name="SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription"/>
            <pathway-xref db="MetaCyc" id="PWY-7737" name="thiocoraline biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-6807505" name="RNA polymerase II transcribes snRNA genes"/>
            <pathway-xref db="Reactome" id="R-HSA-6807505" name="RNA polymerase II transcribes snRNA genes"/>
            <pathway-xref db="MetaCyc" id="PWY-7458" name="violdelphin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7602" name="icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)"/>
            <pathway-xref db="MetaCyc" id="PWY-7706" name="dapdiamides biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8084" name="daurichromenate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7713" name="nivalenol biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7412" name="mycinamicin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7672" name="fusaric acid biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7318" name="dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7988" name="baumannoferrin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7448" name="galloylated catechin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7669" name="equisetin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7529" name="CMP-N-acetyl-7-O-acetylneuraminate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7986" name="anguibactin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5903" name="bacillibactin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7738" name="polyacyltrehalose biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-111465" name="Apoptotic cleavage of cellular proteins"/>
            <pathway-xref db="MetaCyc" id="PWY-7687" name="stipitatate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-5655302" name="Signaling by FGFR1 in disease"/>
            <pathway-xref db="MetaCyc" id="PWY-7689" name="8-O-methylfusarubin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6379" name="alcaligin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7543" name="5-N-acetylardeemin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-6804759" name="Regulation of TP53 Activity through Association with Co-factors"/>
            <pathway-xref db="MetaCyc" id="PWY-8058" name="2-deoxy-D-ribose degradation II"/>
            <pathway-xref db="MetaCyc" id="PWY-7730" name="T-2 toxin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6922" name="L-Ndelta-acetylornithine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-2173795" name="Downregulation of SMAD2/3:SMAD4 transcriptional activity"/>
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        </signature>
        <model-ac>SM00389</model-ac>
        <locations>
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            <pathway-xref db="MetaCyc" id="PWY-5284" name="shisonin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7565" name="aspyridone A biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-6920" name="6-gingerol analog biosynthesis (engineered)"/>
            <pathway-xref db="MetaCyc" id="PWY-7769" name="phosalacine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7688" name="dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-HSA-6807505" name="RNA polymerase II transcribes snRNA genes"/>
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            <pathway-xref db="MetaCyc" id="PWY-7706" name="dapdiamides biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-7713" name="nivalenol biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7412" name="mycinamicin biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-7407" name="aurachin A, B, C and D biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-7405" name="aurachin RE biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-7659" name="viridicatumtoxin biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-7280" name="ternatin C3 biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7029" name="terminal olefins biosynthesis II"/>
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            <pathway-xref db="MetaCyc" id="PWY-7547" name="prodigiosin biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-7555" name="alpha-cyclopiazonate biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-7746" name="mycobacterial sulfolipid biosynthesis"/>
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          <signature-library-release library="PFAM" version="34.0"/>
        </signature>
        <model-ac>PF00046</model-ac>
        <locations>
          <hmmer3-location env-end="204" env-start="148" post-processed="true" score="45.0" evalue="7.1E-12" hmm-start="5" hmm-end="56" hmm-length="57" hmm-bounds="INCOMPLETE" start="152" end="203">
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              <hmmer3-location-fragment start="152" end="203" dc-status="CONTINUOUS"/>
            </location-fragments>
          </hmmer3-location>
        </locations>
      </hmmer3-match>
      <hmmer3-match evalue="7.3E-18" score="65.8">
        <signature ac="G3DSA:1.10.10.60" name="">
          <signature-library-release library="GENE3D" version="4.3.0"/>
        </signature>
        <model-ac>1le8B00</model-ac>
        <locations>
          <hmmer3-location env-end="220" env-start="147" post-processed="true" score="63.4" evalue="4.2E-17" hmm-start="5" hmm-end="69" hmm-length="83" hmm-bounds="COMPLETE" start="147" end="220">
            <location-fragments>
              <hmmer3-location-fragment start="147" end="220" dc-status="CONTINUOUS"/>
            </location-fragments>
          </hmmer3-location>
        </locations>
      </hmmer3-match>
      <hmmer3-match evalue="2.5E-48" score="163.3">
        <signature ac="PF16878" desc="Transcriptional regulator, SIX1, N-terminal SD domain" name="SIX1_SD">
          <entry ac="IPR031701" desc="Homeobox protein SIX1, N-terminal SD domain" name="SIX1_SD" type="DOMAIN"/>
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        </signature>
        <model-ac>PF16878</model-ac>
        <locations>
          <hmmer3-location env-end="142" env-start="28" post-processed="true" score="161.8" evalue="7.2E-48" hmm-start="1" hmm-end="115" hmm-length="115" hmm-bounds="COMPLETE" start="28" end="142">
            <location-fragments>
              <hmmer3-location-fragment start="28" end="142" dc-status="CONTINUOUS"/>
            </location-fragments>
          </hmmer3-location>
        </locations>
      </hmmer3-match>
      <mobidblite-match>
        <signature ac="mobidb-lite" desc="consensus disorder prediction" name="disorder_prediction">
          <signature-library-release library="MOBIDB_LITE" version="2.0"/>
        </signature>
        <model-ac>mobidb-lite</model-ac>
        <locations>
          <mobidblite-location sequence-feature="" start="306" end="469">
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            </location-fragments>
          </mobidblite-location>
        </locations>
      </mobidblite-match>
      <mobidblite-match>
        <signature ac="mobidb-lite" desc="consensus disorder prediction" name="disorder_prediction">
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        <model-ac>mobidb-lite</model-ac>
        <locations>
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      <mobidblite-match>
        <signature ac="mobidb-lite" desc="consensus disorder prediction" name="disorder_prediction">
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        <locations>
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      <mobidblite-match>
        <signature ac="mobidb-lite" desc="consensus disorder prediction" name="disorder_prediction">
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        <model-ac>mobidb-lite</model-ac>
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          </mobidblite-location>
        </locations>
      </mobidblite-match>
      <mobidblite-match>
        <signature ac="mobidb-lite" desc="consensus disorder prediction" name="disorder_prediction">
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        <model-ac>mobidb-lite</model-ac>
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      <mobidblite-match>
        <signature ac="mobidb-lite" desc="consensus disorder prediction" name="disorder_prediction">
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        <model-ac>mobidb-lite</model-ac>
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          </mobidblite-location>
        </locations>
      </mobidblite-match>
      <panther-match evalue="2.7E-130" familyName="PROTEIN OPTIX" score="447.4">
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          </panther-location>
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      </panther-match>
      <panther-match evalue="2.7E-130" familyName="PROTEIN OPTIX" score="447.4">
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      <profilescan-match>
        <signature ac="PS50071" desc="'Homeobox' domain profile." name="HOMEOBOX_2">
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            <pathway-xref db="MetaCyc" id="PWY-7606" name="docosahexaenoate biosynthesis III (6-desaturase, mammals)"/>
            <pathway-xref db="MetaCyc" id="PWY-7474" name="avenacin A-2 biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-8941855" name="RUNX3 regulates CDKN1A transcription"/>
            <pathway-xref db="MetaCyc" id="PWY-7696" name="citreoisocoumarin and bikisocoumarin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8133" name="succinoglycan biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-76071" name="RNA Polymerase III Transcription Initiation From Type 3 Promoter"/>
            <pathway-xref db="MetaCyc" id="PWY-81" name="toluene degradation to benzoyl-CoA (anaerobic)"/>
            <pathway-xref db="MetaCyc" id="PWY-7532" name="acetylaszonalenin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-1660661" name="Sphingolipid de novo biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8040" name="ansatrienin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8272" name="Escherichia coli serotype O:49 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-2892245" name="POU5F1 (OCT4), SOX2, NANOG repress genes related to differentiation"/>
            <pathway-xref db="MetaCyc" id="PWY-6971" name="oleandomycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-381771" name="Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)"/>
            <pathway-xref db="MetaCyc" id="PWY-8053" name="anandamide biosynthesis II"/>
            <pathway-xref db="MetaCyc" id="PWY-8049" name="pederin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6036" name="cardenolide glucosides biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-1839117" name="Signaling by cytosolic FGFR1 fusion mutants"/>
            <pathway-xref db="Reactome" id="R-MMU-8941855" name="RUNX3 regulates CDKN1A transcription"/>
            <pathway-xref db="Reactome" id="R-HSA-2559582" name="Senescence-Associated Secretory Phenotype (SASP)"/>
            <pathway-xref db="Reactome" id="R-MMU-4551638" name="SUMOylation of chromatin organization proteins"/>
            <pathway-xref db="MetaCyc" id="PWY-7172" name="flavonol acylglucoside biosynthesis III - quercetin derivatives"/>
            <pathway-xref db="MetaCyc" id="PWY-6314" name="plumbagin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7612" name="chaetoglobosin A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-5578768" name="Physiological factors"/>
            <pathway-xref db="MetaCyc" id="PWY-6373" name="acrylate degradation I"/>
            <pathway-xref db="MetaCyc" id="PWY-7671" name="saframycin A biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6032" name="digitoxigenin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7592" name="arachidonate biosynthesis III (6-desaturase, mammals)"/>
            <pathway-xref db="MetaCyc" id="PWY-7693" name="guadinomine B biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-452723" name="Transcriptional regulation of pluripotent stem cells"/>
            <pathway-xref db="MetaCyc" id="PWY-5129" name="sphingolipid biosynthesis (plants)"/>
            <pathway-xref db="MetaCyc" id="PWY-7473" name="avenacin A-1 biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7461" name="hydroxycinnamate sugar acid ester biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7727" name="docosahexaenoate biosynthesis IV (4-desaturase, mammals)"/>
            <pathway-xref db="MetaCyc" id="PWY-7716" name="penicillin G and penicillin V biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6749" name="CMP-legionaminate biosynthesis I"/>
            <pathway-xref db="MetaCyc" id="PWY-8166" name="emodin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6312" name="barbaloin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7653" name="griseofulvin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-1660661" name="Sphingolipid de novo biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-4551638" name="SUMOylation of chromatin organization proteins"/>
            <pathway-xref db="MetaCyc" id="PWY-8152" name="androstenedione degradation II (anaerobic)"/>
            <pathway-xref db="MetaCyc" id="PWY-5048" name="rosmarinic acid biosynthesis I"/>
            <pathway-xref db="MetaCyc" id="PWY-8012" name="mupirocin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-361" name="phenylpropanoid biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-8939902" name="Regulation of RUNX2 expression and activity"/>
            <pathway-xref db="MetaCyc" id="PWY-761" name="rhizobactin 1021 biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7475" name="des-methyl avenacin A-1 biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7989" name="acinetoferrin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6320" name="phaselate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-210744" name="Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells"/>
            <pathway-xref db="Reactome" id="R-HSA-76071" name="RNA Polymerase III Transcription Initiation From Type 3 Promoter"/>
            <pathway-xref db="MetaCyc" id="PWY-7673" name="fusarin C biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7677" name="rosamicin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-4801" name="aloesone biosynthesis I"/>
            <pathway-xref db="MetaCyc" id="PWY-6407" name="yersiniabactin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7171" name="flavonol acylglucoside biosynthesis II - isorhamnetin derivatives"/>
            <pathway-xref db="MetaCyc" id="PWY-8055" name="palmitoyl ethanolamide biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7261" name="anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)"/>
            <pathway-xref db="Reactome" id="R-HSA-210747" name="Regulation of gene expression in early pancreatic precursor cells"/>
            <pathway-xref db="MetaCyc" id="PWY-8042" name="acylceramide biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7585" name="docosahexaenoate biosynthesis II (bacteria)"/>
            <pathway-xref db="MetaCyc" id="PWY-7563" name="bassianin and desmethylbassianin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-5617472" name="Activation of anterior HOX genes in hindbrain development during early embryogenesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6672" name="cis-geranyl-CoA degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7695" name="aurofusarin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5984" name="rifamycin B biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6442" name="spermidine hydroxycinnamic acid conjugates biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6722" name="candicidin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5975" name="furaneol and mesifurane biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7450" name="anthocyanidin modification (Arabidopsis)"/>
            <pathway-xref db="MetaCyc" id="PWY-7045" name="mithramycin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5353" name="arachidonate biosynthesis I (6-desaturase, lower eukaryotes)"/>
            <pathway-xref db="MetaCyc" id="PWY-7354" name="aclacinomycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9018519" name="Estrogen-dependent gene expression"/>
            <pathway-xref db="Reactome" id="R-MMU-6807505" name="RNA polymerase II transcribes snRNA genes"/>
            <pathway-xref db="MetaCyc" id="PWY-7415" name="tylosin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-8939245" name="RUNX1 regulates transcription of genes involved in BCR signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-7679" name="anthocyanidin acylglucoside and acylsambubioside biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6946" name="cholesterol degradation to androstenedione II (cholesterol dehydrogenase)"/>
            <pathway-xref db="MetaCyc" id="PWY-7530" name="Escherichia coli serotype O:104 O antigen biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7702" name="sch210971 and sch210972 biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5268" name="salvianin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6958" name="icosapentaenoate biosynthesis I (lower eukaryotes)"/>
            <pathway-xref db="Reactome" id="R-DME-8941855" name="RUNX3 regulates CDKN1A transcription"/>
            <pathway-xref db="Reactome" id="R-MMU-9018519" name="Estrogen-dependent gene expression"/>
            <pathway-xref db="MetaCyc" id="PWY-6673" name="caffeoylglucarate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6799" name="fatty acid biosynthesis initiation (plant mitochondria)"/>
            <pathway-xref db="MetaCyc" id="PWY-5473" name="hydroxycinnamic acid serotonin amides biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7656" name="Spodoptera littoralis pheromone biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6453" name="stigma estolide biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-8853884" name="Transcriptional Regulation by VENTX"/>
            <pathway-xref db="MetaCyc" id="PWY-5875" name="staphyloxanthin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-4922" name="6-methoxymellein biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5475" name="pentagalloylglucose biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7692" name="bikaverin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6056" name="dimethylsulfoniopropanoate degradation II (cleavage)"/>
            <pathway-xref db="MetaCyc" id="PWY-7811" name="6-methylpretetramide biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-111465" name="Apoptotic cleavage of cellular proteins"/>
            <pathway-xref db="MetaCyc" id="PWY-8157" name="avenanthramide biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6316" name="aromatic polyketides biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7452" name="cyanidin dimalonylglucoside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-390193" name="Transcriptional activation by YKI"/>
            <pathway-xref db="MetaCyc" id="PWY-8082" name="glycine lipid biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5284" name="shisonin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7565" name="aspyridone A biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8032" name="chloramphenicol biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-6807505" name="RNA polymerase II transcribes snRNA genes"/>
            <pathway-xref db="MetaCyc" id="PWY-7050" name="icosapentaenoate biosynthesis IV (bacteria)"/>
            <pathway-xref db="MetaCyc" id="PWY-6920" name="6-gingerol analog biosynthesis (engineered)"/>
            <pathway-xref db="MetaCyc" id="PWY-7769" name="phosalacine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7688" name="dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWYG-321" name="mycolate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6378" name="putrebactin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8038" name="naphthomycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-2173796" name="SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription"/>
            <pathway-xref db="MetaCyc" id="PWY-7737" name="thiocoraline biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-6807505" name="RNA polymerase II transcribes snRNA genes"/>
            <pathway-xref db="Reactome" id="R-HSA-6807505" name="RNA polymerase II transcribes snRNA genes"/>
            <pathway-xref db="MetaCyc" id="PWY-7458" name="violdelphin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7602" name="icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)"/>
            <pathway-xref db="MetaCyc" id="PWY-7706" name="dapdiamides biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8084" name="daurichromenate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7713" name="nivalenol biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7412" name="mycinamicin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7672" name="fusaric acid biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7318" name="dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7988" name="baumannoferrin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7448" name="galloylated catechin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7669" name="equisetin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7529" name="CMP-N-acetyl-7-O-acetylneuraminate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7986" name="anguibactin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5903" name="bacillibactin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7738" name="polyacyltrehalose biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-111465" name="Apoptotic cleavage of cellular proteins"/>
            <pathway-xref db="MetaCyc" id="PWY-7687" name="stipitatate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-5655302" name="Signaling by FGFR1 in disease"/>
            <pathway-xref db="MetaCyc" id="PWY-7689" name="8-O-methylfusarubin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6379" name="alcaligin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7543" name="5-N-acetylardeemin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-6804759" name="Regulation of TP53 Activity through Association with Co-factors"/>
            <pathway-xref db="MetaCyc" id="PWY-8058" name="2-deoxy-D-ribose degradation II"/>
            <pathway-xref db="MetaCyc" id="PWY-7730" name="T-2 toxin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6922" name="L-Ndelta-acetylornithine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-2173795" name="Downregulation of SMAD2/3:SMAD4 transcriptional activity"/>
            <pathway-xref db="MetaCyc" id="PWY-5846" name="colchicine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5313" name="superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)"/>
            <pathway-xref db="MetaCyc" id="PWY-7577" name="ferrichrome biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-8853884" name="Transcriptional Regulation by VENTX"/>
            <pathway-xref db="MetaCyc" id="PWY-7407" name="aurachin A, B, C and D biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6930" name="phenolic malonylglucosides biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7470" name="phosphatidylcholine biosynthesis VII"/>
            <pathway-xref db="MetaCyc" id="PWY-6627" name="salinosporamide A biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7708" name="lyngbyatoxin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7940" name="lauryl-hydroxychlorobactene glucoside biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5679" name="clavulanate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6944" name="androstenedione degradation I (aerobic)"/>
            <pathway-xref db="MetaCyc" id="PWY-7405" name="aurachin RE biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6310" name="aloesone biosynthesis II"/>
            <pathway-xref db="MetaCyc" id="PWY-7561" name="tenellin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6039" name="chlorogenic acid biosynthesis I"/>
            <pathway-xref db="Reactome" id="R-HSA-210745" name="Regulation of gene expression in beta cells"/>
            <pathway-xref db="MetaCyc" id="PWY-7987" name="vanchrobactin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6945" name="cholesterol degradation to androstenedione I (cholesterol oxidase)"/>
            <pathway-xref db="MetaCyc" id="PWY-7464" name="cyanidin 3,7-diglucoside polyacylation biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7815" name="poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)"/>
            <pathway-xref db="MetaCyc" id="PWY-7726" name="(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)"/>
            <pathway-xref db="MetaCyc" id="PWY-8075" name="(Kdo)2-lipid A biosynthesis (P. putida)"/>
            <pathway-xref db="MetaCyc" id="PWY-7659" name="viridicatumtoxin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7821" name="tunicamycin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-84" name="resveratrol biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5794" name="malonate degradation I (biotin-independent)"/>
            <pathway-xref db="Reactome" id="R-MMU-3214847" name="HATs acetylate histones"/>
            <pathway-xref db="MetaCyc" id="PWY-7728" name="(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)"/>
            <pathway-xref db="MetaCyc" id="PWY-8210" name="pyrrolomycin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5292" name="vindoline, vindorosine and vinblastine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9013508" name="NOTCH3 Intracellular Domain Regulates Transcription"/>
            <pathway-xref db="Reactome" id="R-HSA-6804759" name="Regulation of TP53 Activity through Association with Co-factors"/>
            <pathway-xref db="MetaCyc" id="PWY-7280" name="ternatin C3 biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7029" name="terminal olefins biosynthesis II"/>
            <pathway-xref db="Reactome" id="R-HSA-749476" name="RNA Polymerase III Abortive And Retractive Initiation"/>
            <pathway-xref db="MetaCyc" id="PWY-7670" name="fusaridione A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-2173795" name="Downregulation of SMAD2/3:SMAD4 transcriptional activity"/>
            <pathway-xref db="MetaCyc" id="PWY-7547" name="prodigiosin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7984" name="acinetobactin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7660" name="tryptoquialanine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6027" name="capsiconiate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-2032785" name="YAP1- and WWTR1 (TAZ)-stimulated gene expression"/>
            <pathway-xref db="MetaCyc" id="PWY-7907" name="(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-6785807" name="Interleukin-4 and Interleukin-13 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-7555" name="alpha-cyclopiazonate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7954" name="tabtoxinine-beta-lactam biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7746" name="mycobacterial sulfolipid biosynthesis"/>
          </entry>
          <signature-library-release library="PROSITE_PROFILES" version="2021_01"/>
        </signature>
        <model-ac>PS50071</model-ac>
        <locations>
          <profilescan-location score="14.365655" start="145" end="205">
            <location-fragments>
              <profilescan-location-fragment start="145" end="205" dc-status="CONTINUOUS"/>
            </location-fragments>
            <alignment>WDGEQKTHCFKERTRSLLREWYLQDPYPNPGKKRELAAATGLTPTQVGNWFKNRRQRDRAA</alignment>
          </profilescan-location>
        </locations>
      </profilescan-match>
      <rpsblast-match>
        <signature ac="cd00086" desc="homeodomain" name="homeodomain">
          <entry ac="IPR001356" desc="Homeobox domain" name="Homeobox_dom" type="DOMAIN">
            <go-xref category="MOLECULAR_FUNCTION" db="GO" id="GO:0003677" name="DNA binding"/>
            <pathway-xref db="MetaCyc" id="PWY-7735" name="echinomycin and triostin A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-2892247" name="POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation"/>
            <pathway-xref db="MetaCyc" id="PWY-8151" name="cholesterol degradation to androstenedione III (anaerobic)"/>
            <pathway-xref db="MetaCyc" id="PWY-7694" name="zwittermicin A biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7265" name="lampranthin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7382" name="lipoate biosynthesis and incorporation IV (yeast)"/>
            <pathway-xref db="MetaCyc" id="PWY-7053" name="docosahexaenoate biosynthesis I (lower eukaryotes)"/>
            <pathway-xref db="Reactome" id="R-RNO-6804759" name="Regulation of TP53 Activity through Association with Co-factors"/>
            <pathway-xref db="MetaCyc" id="PWY-8035" name="streptovaricin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7621" name="autoinducer CAI-1 biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-76071" name="RNA Polymerase III Transcription Initiation From Type 3 Promoter"/>
            <pathway-xref db="MetaCyc" id="PWY-7583" name="arachidonate biosynthesis II (bacteria)"/>
            <pathway-xref db="MetaCyc" id="PWY-7049" name="icosapentaenoate biosynthesis II (6-desaturase, mammals)"/>
            <pathway-xref db="MetaCyc" id="PWY-5994" name="palmitate biosynthesis I (type I fatty acid synthase)"/>
            <pathway-xref db="MetaCyc" id="PWY-7419" name="FR-900098 and FR-33289 antibiotics biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7818" name="type IV lipoteichoic acid biosynthesis (S. pneumoniae)"/>
            <pathway-xref db="MetaCyc" id="PWY-5139" name="pelargonidin conjugates biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7460" name="2-O-acetyl-3-O-trans-coutarate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-210746" name="Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells"/>
            <pathway-xref db="Reactome" id="R-HSA-9010553" name="Regulation of expression of SLITs and ROBOs"/>
            <pathway-xref db="MetaCyc" id="PWY-8047" name="bryostatin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7624" name="nystatin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7711" name="calonectrin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6397" name="mycolyl-arabinogalactan-peptidoglycan complex biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5477" name="gallotannin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-4551638" name="SUMOylation of chromatin organization proteins"/>
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        </signature>
        <model-ac>cd00086</model-ac>
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                  <site-location residue="C" start="153" end="153"/>
                  <site-location residue="N" start="193" end="193"/>
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                  <site-location residue="K" start="196" end="196"/>
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              </rpsblast-site>
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      <superfamilyhmmer3-match evalue="2.01E-16">
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            <pathway-xref db="MetaCyc" id="PWY-84" name="resveratrol biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-7984" name="acinetobactin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6027" name="capsiconiate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-2032785" name="YAP1- and WWTR1 (TAZ)-stimulated gene expression"/>
            <pathway-xref db="MetaCyc" id="PWY-7907" name="(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-6785807" name="Interleukin-4 and Interleukin-13 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-7555" name="alpha-cyclopiazonate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7954" name="tabtoxinine-beta-lactam biosynthesis"/>
          </entry>
          <signature-library-release library="SUPERFAMILY" version="1.75"/>
        </signature>
        <model-ac>0052496</model-ac>
        <locations>
          <superfamilyhmmer3-location hmm-length="76" start="145" end="212">
            <location-fragments>
              <superfamilyhmmer3-location-fragment start="145" end="212" dc-status="CONTINUOUS"/>
            </location-fragments>
          </superfamilyhmmer3-location>
        </locations>
      </superfamilyhmmer3-match>
    </matches>
  </protein>
  <protein>
    <sequence md5="0c2f92a7908139adee3701db31e2c49e">MPLVRKPMRYAHQEGHTDVCYYSGEKRGLITCGCDGDVRYWLNLMDDDPATSCISEQAITVISKDGKIFVGNDNNTVQMLTYPDLEKEGIVTRFSAPVSALATTKDSNLIVSGSCDMRIHVTNITTSDSIELEGHGAPILGLSLDPKEEFVTSSSADGSIRVWNIKEKKTVHVWNNIVPKCNSFFTAKSYCTPSFKCTDGSCLAYPSNKDVVIVERLSWKELYRLKCPTLKTELNICKFSECGTRIAASSLHGEIIVWNIDTKEVIGYLEHEIDTKITALVWHIDHSNEIAFCDALGKLGCVDVISSNKPENEKILDSEINEDVMENDFTLLGDDDDDENVISLNKIKASVNLEDDQKSQTASEKLPYDSKAFMPSVKLQSPFQPGSTPSHLLSYFMMWNDVGMVRCFTSEDDENSSIEVEFHNAAIHRSMHINNYFRHSMAALSTQALALSCAASDNGPSKIVVISLQGWGSGNKEWSLDLPEGEESECLAAGDNFVAVATSRRNLRIFMIGGTQREILALPGPVVAMNGLGNRLLVAYHAGIGPAGDQNMNLLWIQIQGAHVRSQTLTIPLSPTSDLMWLGLSDANSPIVIDSDDIIRIYDKRSCQWRVLCDTNIQDKGKADHYFVIGVSEQEQNMRCILCKGSYYPPTIPLPIITEVSFSAPLCEPESEKTKEERKLWEIGSNPSDATEALLTLIALACRSNLEYRAVDICEQIASTKAIDLAIRYALRVSKTALAKKLEAIADVKSDSKDSKEEEEMENQEDNFTSNSDFSINNEEDNNILLPSIKKPEVEIKPLSMSQTLKRVNPFLKAGNSSLSPRGLAGLNSLPEKPQKPVNIVPVKPKSKTESRKESFVTWYAKNRKKLQEEFPEINVVELTKIGLTRYKEETTKSNNVENAVESSELNKKRKLSSLVPLDTVQEAMGSMGPWHIVIVVAISLVKFPVAWHQLSIVFLAPPTNFSCIAPLSATNDSTIMKCEIDVGNGTMEKCTDFKYDKRIFRESIITQWNLVCDKEQLANFAQSCTMFGVLIGNLIFSVMADRIGRKKPLMIAIALQSVTGFASAFAPWYELFXILKFICALATGGTMLVSFVLLMEIIGIEWRSIMSVLFHVPFLLGHLMNPLISYLTHGTWSGFQMAVSIPSVFLLAYYWIIPESPRWLLAMGKPRQAERILLKAAERNKIPVENVKVALETHENQAAIRITKSKEKYNITHLFRTPNLRLKTICVSINWFVCGMCFFGLAQYMGHLDGDIFINVAVSAAMELPGTVIVLFLISRVSRLKILIGGNILSGVSLLLITLMTNASARIFLASLGLVGMAISFPTIYLYSGEVFPTVVRNIGVGLGSISARIGSIIAPYIATMGTIQPWLPPVIFAIGPMLGAVLCLLLPETMNCELPETIEDSENFGKKKPKESTSST</sequence>
    <xref id="XP_029177123.1" name="XP_029177123.1 LOW QUALITY PROTEIN: WD repeat and HMG-box DNA-binding protein 1-like [Nylanderia fulva]"/>
    <matches>
      <hmmer2-match evalue="6.4E-18" score="75.5">
        <signature ac="SM00320" name="WD40_4">
          <entry ac="IPR001680" desc="WD40 repeat" name="WD40_repeat" type="REPEAT">
            <go-xref category="MOLECULAR_FUNCTION" db="GO" id="GO:0005515" name="protein binding"/>
            <pathway-xref db="Reactome" id="R-DME-674695" name="RNA Polymerase II Pre-transcription Events"/>
            <pathway-xref db="Reactome" id="R-HSA-9610379" name="HCMV Late Events"/>
            <pathway-xref db="Reactome" id="R-RNO-3301854" name="Nuclear Pore Complex (NPC) Disassembly"/>
            <pathway-xref db="Reactome" id="R-HSA-4615885" name="SUMOylation of DNA replication proteins"/>
            <pathway-xref db="Reactome" id="R-HSA-6803207" name="TP53 Regulates Transcription of Caspase Activators and Caspases"/>
            <pathway-xref db="Reactome" id="R-HSA-2565942" name="Regulation of PLK1 Activity at G2/M Transition"/>
            <pathway-xref db="Reactome" id="R-DME-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-GGA-1632852" name="Macroautophagy"/>
            <pathway-xref db="MetaCyc" id="PWY-6363" name="D-myo-inositol (1,4,5)-trisphosphate degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-6791226" name="Major pathway of rRNA processing in the nucleolus and cytosol"/>
            <pathway-xref db="Reactome" id="R-BTA-5628897" name="TP53 Regulates Metabolic Genes"/>
            <pathway-xref db="Reactome" id="R-MMU-5620912" name="Anchoring of the basal body to the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-MMU-2565942" name="Regulation of PLK1 Activity at G2/M Transition"/>
            <pathway-xref db="Reactome" id="R-DME-9639288" name="Amino acids regulate mTORC1"/>
            <pathway-xref db="Reactome" id="R-MMU-6811434" name="COPI-dependent Golgi-to-ER retrograde traffic"/>
            <pathway-xref db="Reactome" id="R-CFA-6814122" name="Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"/>
            <pathway-xref db="Reactome" id="R-SCE-9696273" name="RND1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-5620912" name="Anchoring of the basal body to the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-MMU-6791226" name="Major pathway of rRNA processing in the nucleolus and cytosol"/>
            <pathway-xref db="Reactome" id="R-DRE-5620924" name="Intraflagellar transport"/>
            <pathway-xref db="Reactome" id="R-MMU-5674135" name="MAP2K and MAPK activation"/>
            <pathway-xref db="Reactome" id="R-GGA-5696400" name="Dual Incision in GG-NER"/>
            <pathway-xref db="Reactome" id="R-RNO-6804757" name="Regulation of TP53 Degradation"/>
            <pathway-xref db="Reactome" id="R-DRE-159227" name="Transport of the SLBP independent Mature mRNA"/>
            <pathway-xref db="Reactome" id="R-MMU-171319" name="Telomere Extension By Telomerase"/>
            <pathway-xref db="Reactome" id="R-DDI-9013149" name="RAC1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DRE-5663220" name="RHO GTPases Activate Formins"/>
            <pathway-xref db="Reactome" id="R-DRE-5696394" name="DNA Damage Recognition in GG-NER"/>
            <pathway-xref db="Reactome" id="R-BTA-3214841" name="PKMTs methylate histone lysines"/>
            <pathway-xref db="Reactome" id="R-SPO-1257604" name="PIP3 activates AKT signaling"/>
            <pathway-xref db="Reactome" id="R-DME-209461" name="Ubiquitination and degradation of phosphorylated ARM"/>
            <pathway-xref db="Reactome" id="R-DDI-179409" name="APC-Cdc20 mediated degradation of Nek2A"/>
            <pathway-xref db="Reactome" id="R-HSA-1660514" name="Synthesis of PIPs at the Golgi membrane"/>
            <pathway-xref db="Reactome" id="R-MMU-4615885" name="SUMOylation of DNA replication proteins"/>
            <pathway-xref db="Reactome" id="R-HSA-997272" name="Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits"/>
            <pathway-xref db="Reactome" id="R-DDI-5628897" name="TP53 Regulates Metabolic Genes"/>
            <pathway-xref db="Reactome" id="R-SPO-75955" name="RNA Polymerase II Transcription Elongation"/>
            <pathway-xref db="Reactome" id="R-SCE-72702" name="Ribosomal scanning and start codon recognition"/>
            <pathway-xref db="Reactome" id="R-RNO-380270" name="Recruitment of mitotic centrosome proteins and complexes"/>
            <pathway-xref db="Reactome" id="R-DME-72649" name="Translation initiation complex formation"/>
            <pathway-xref db="Reactome" id="R-DME-500657" name="Presynaptic function of Kainate receptors"/>
            <pathway-xref db="Reactome" id="R-MMU-8964616" name="G beta:gamma signalling through CDC42"/>
            <pathway-xref db="Reactome" id="R-DRE-9013407" name="RHOH GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DRE-9018519" name="Estrogen-dependent gene expression"/>
            <pathway-xref db="Reactome" id="R-MMU-420092" name="Glucagon-type ligand receptors"/>
            <pathway-xref db="Reactome" id="R-HSA-400253" name="Circadian Clock"/>
            <pathway-xref db="Reactome" id="R-HSA-8964616" name="G beta:gamma signalling through CDC42"/>
            <pathway-xref db="Reactome" id="R-BTA-2029482" name="Regulation of actin dynamics for phagocytic cup formation"/>
            <pathway-xref db="Reactome" id="R-DRE-72689" name="Formation of a pool of free 40S subunits"/>
            <pathway-xref db="Reactome" id="R-DRE-3371571" name="HSF1-dependent transactivation"/>
            <pathway-xref db="Reactome" id="R-CEL-202040" name="G-protein activation"/>
            <pathway-xref db="Reactome" id="R-SPO-8856828" name="Clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-SCE-3371571" name="HSF1-dependent transactivation"/>
            <pathway-xref db="Reactome" id="R-MMU-72163" name="mRNA Splicing - Major Pathway"/>
            <pathway-xref db="Reactome" id="R-DDI-1660517" name="Synthesis of PIPs at the late endosome membrane"/>
            <pathway-xref db="Reactome" id="R-SPO-9696270" name="RND2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-191859" name="snRNP Assembly"/>
            <pathway-xref db="Reactome" id="R-SPO-176407" name="Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase"/>
            <pathway-xref db="Reactome" id="R-DRE-6814122" name="Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"/>
            <pathway-xref db="Reactome" id="R-SSC-176407" name="Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase"/>
            <pathway-xref db="Reactome" id="R-DRE-392170" name="ADP signalling through P2Y purinoceptor 12"/>
            <pathway-xref db="Reactome" id="R-HSA-1368108" name="BMAL1:CLOCK,NPAS2 activates circadian gene expression"/>
            <pathway-xref db="Reactome" id="R-HSA-6811434" name="COPI-dependent Golgi-to-ER retrograde traffic"/>
            <pathway-xref db="Reactome" id="R-MMU-141405" name="Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components"/>
            <pathway-xref db="Reactome" id="R-SCE-975957" name="Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"/>
            <pathway-xref db="Reactome" id="R-HSA-5674135" name="MAP2K and MAPK activation"/>
            <pathway-xref db="Reactome" id="R-HSA-72689" name="Formation of a pool of free 40S subunits"/>
            <pathway-xref db="Reactome" id="R-HSA-5610780" name="Degradation of GLI1 by the proteasome"/>
            <pathway-xref db="Reactome" id="R-HSA-390471" name="Association of TriC/CCT with target proteins during biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DDI-2029482" name="Regulation of actin dynamics for phagocytic cup formation"/>
            <pathway-xref db="Reactome" id="R-DME-209440" name="Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM"/>
            <pathway-xref db="Reactome" id="R-SCE-73776" name="RNA Polymerase II Promoter Escape"/>
            <pathway-xref db="Reactome" id="R-DRE-6804758" name="Regulation of TP53 Activity through Acetylation"/>
            <pathway-xref db="Reactome" id="R-SCE-156827" name="L13a-mediated translational silencing of Ceruloplasmin expression"/>
            <pathway-xref db="Reactome" id="R-DRE-3232142" name="SUMOylation of ubiquitinylation proteins"/>
            <pathway-xref db="Reactome" id="R-SPO-9615933" name="Postmitotic nuclear pore complex (NPC) reformation"/>
            <pathway-xref db="Reactome" id="R-RNO-9648025" name="EML4 and NUDC in mitotic spindle formation"/>
            <pathway-xref db="Reactome" id="R-MMU-1660514" name="Synthesis of PIPs at the Golgi membrane"/>
            <pathway-xref db="Reactome" id="R-HSA-171319" name="Telomere Extension By Telomerase"/>
            <pathway-xref db="Reactome" id="R-DRE-3108214" name="SUMOylation of DNA damage response and repair proteins"/>
            <pathway-xref db="Reactome" id="R-DDI-9033241" name="Peroxisomal protein import"/>
            <pathway-xref db="Reactome" id="R-DME-6807878" name="COPI-mediated anterograde transport"/>
            <pathway-xref db="Reactome" id="R-MMU-2871837" name="FCERI mediated NF-kB activation"/>
            <pathway-xref db="Reactome" id="R-MMU-975957" name="Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"/>
            <pathway-xref db="Reactome" id="R-DRE-380972" name="Energy dependent regulation of mTOR by LKB1-AMPK"/>
            <pathway-xref db="Reactome" id="R-MMU-174084" name="Autodegradation of Cdh1 by Cdh1:APC/C"/>
            <pathway-xref db="Reactome" id="R-BTA-606279" name="Deposition of new CENPA-containing nucleosomes at the centromere"/>
            <pathway-xref db="Reactome" id="R-CEL-418597" name="G alpha (z) signalling events"/>
            <pathway-xref db="MetaCyc" id="PWY-7831" name="ABH and Lewis epitopes biosynthesis from type 2 precursor disaccharide"/>
            <pathway-xref db="Reactome" id="R-HSA-4085377" name="SUMOylation of SUMOylation proteins"/>
            <pathway-xref db="Reactome" id="R-HSA-420092" name="Glucagon-type ligand receptors"/>
            <pathway-xref db="Reactome" id="R-DME-2995383" name="Initiation of Nuclear Envelope (NE) Reformation"/>
            <pathway-xref db="Reactome" id="R-RNO-9696273" name="RND1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-GGA-5696395" name="Formation of Incision Complex in GG-NER"/>
            <pathway-xref db="Reactome" id="R-SPO-389357" name="CD28 dependent PI3K/Akt signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-5620924" name="Intraflagellar transport"/>
            <pathway-xref db="Reactome" id="R-DDI-72689" name="Formation of a pool of free 40S subunits"/>
            <pathway-xref db="Reactome" id="R-SSC-141430" name="Inactivation of APC/C via direct inhibition of the APC/C complex"/>
            <pathway-xref db="Reactome" id="R-HSA-174154" name="APC/C:Cdc20 mediated degradation of Securin"/>
            <pathway-xref db="Reactome" id="R-RNO-2173788" name="Downregulation of TGF-beta receptor signaling"/>
            <pathway-xref db="Reactome" id="R-DRE-3301854" name="Nuclear Pore Complex (NPC) Disassembly"/>
            <pathway-xref db="Reactome" id="R-MMU-9615933" name="Postmitotic nuclear pore complex (NPC) reformation"/>
            <pathway-xref db="Reactome" id="R-CEL-201722" name="Formation of the beta-catenin:TCF transactivating complex"/>
            <pathway-xref db="Reactome" id="R-RNO-5218920" name="VEGFR2 mediated vascular permeability"/>
            <pathway-xref db="Reactome" id="R-HSA-5626978" name="TNFR1-mediated ceramide production"/>
            <pathway-xref db="Reactome" id="R-RNO-8936459" name="RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"/>
            <pathway-xref db="Reactome" id="R-SPO-72706" name="GTP hydrolysis and joining of the 60S ribosomal subunit"/>
            <pathway-xref db="Reactome" id="R-SCE-141405" name="Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components"/>
            <pathway-xref db="Reactome" id="R-SPO-5578749" name="Transcriptional regulation by small RNAs"/>
            <pathway-xref db="Reactome" id="R-MMU-1296041" name="Activation of G protein gated Potassium channels"/>
            <pathway-xref db="Reactome" id="R-HSA-2465910" name="MASTL Facilitates Mitotic Progression"/>
            <pathway-xref db="Reactome" id="R-HSA-156827" name="L13a-mediated translational silencing of Ceruloplasmin expression"/>
            <pathway-xref db="Reactome" id="R-CFA-392170" name="ADP signalling through P2Y purinoceptor 12"/>
            <pathway-xref db="Reactome" id="R-MMU-72187" name="mRNA 3'-end processing"/>
            <pathway-xref db="Reactome" id="R-DDI-75955" name="RNA Polymerase II Transcription Elongation"/>
            <pathway-xref db="Reactome" id="R-DDI-6782135" name="Dual incision in TC-NER"/>
            <pathway-xref db="Reactome" id="R-GGA-110314" name="Recognition of DNA damage by PCNA-containing replication complex"/>
            <pathway-xref db="Reactome" id="R-MMU-1655829" name="Regulation of cholesterol biosynthesis by SREBP (SREBF)"/>
            <pathway-xref db="Reactome" id="R-MMU-68877" name="Mitotic Prometaphase"/>
            <pathway-xref db="Reactome" id="R-HSA-5696395" name="Formation of Incision Complex in GG-NER"/>
            <pathway-xref db="Reactome" id="R-DDI-380972" name="Energy dependent regulation of mTOR by LKB1-AMPK"/>
            <pathway-xref db="Reactome" id="R-XTR-2559580" name="Oxidative Stress Induced Senescence"/>
            <pathway-xref db="Reactome" id="R-HSA-195253" name="Degradation of beta-catenin by the destruction complex"/>
            <pathway-xref db="Reactome" id="R-MMU-430039" name="mRNA decay by 5' to 3' exoribonuclease"/>
            <pathway-xref db="Reactome" id="R-MMU-8951664" name="Neddylation"/>
            <pathway-xref db="Reactome" id="R-RNO-111458" name="Formation of apoptosome"/>
            <pathway-xref db="Reactome" id="R-CEL-381753" name="Olfactory Signaling Pathway"/>
            <pathway-xref db="Reactome" id="R-HSA-1655829" name="Regulation of cholesterol biosynthesis by SREBP (SREBF)"/>
            <pathway-xref db="Reactome" id="R-HSA-9013418" name="RHOBTB2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-159230" name="Transport of the SLBP Dependant Mature mRNA"/>
            <pathway-xref db="Reactome" id="R-HSA-174048" name="APC/C:Cdc20 mediated degradation of Cyclin B"/>
            <pathway-xref db="Reactome" id="R-HSA-8943724" name="Regulation of PTEN gene transcription"/>
            <pathway-xref db="Reactome" id="R-DME-3769402" name="Deactivation of the beta-catenin transactivating complex"/>
            <pathway-xref db="Reactome" id="R-DME-72187" name="mRNA 3'-end processing"/>
            <pathway-xref db="Reactome" id="R-CEL-204005" name="COPII-mediated vesicle transport"/>
            <pathway-xref db="Reactome" id="R-CFA-400042" name="Adrenaline,noradrenaline inhibits insulin secretion"/>
            <pathway-xref db="Reactome" id="R-SCE-69656" name="Cyclin A:Cdk2-associated events at S phase entry"/>
            <pathway-xref db="Reactome" id="R-MMU-8943724" name="Regulation of PTEN gene transcription"/>
            <pathway-xref db="Reactome" id="R-RNO-6814122" name="Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"/>
            <pathway-xref db="Reactome" id="R-DRE-6804757" name="Regulation of TP53 Degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-176408" name="Regulation of APC/C activators between G1/S and early anaphase"/>
            <pathway-xref db="Reactome" id="R-MMU-9013418" name="RHOBTB2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-1362300" name="Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1"/>
            <pathway-xref db="Reactome" id="R-DRE-75955" name="RNA Polymerase II Transcription Elongation"/>
            <pathway-xref db="Reactome" id="R-DME-416476" name="G alpha (q) signalling events"/>
            <pathway-xref db="Reactome" id="R-DDI-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-CEL-72689" name="Formation of a pool of free 40S subunits"/>
            <pathway-xref db="Reactome" id="R-MMU-606279" name="Deposition of new CENPA-containing nucleosomes at the centromere"/>
            <pathway-xref db="Reactome" id="R-GGA-141444" name="Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"/>
            <pathway-xref db="Reactome" id="R-MMU-69656" name="Cyclin A:Cdk2-associated events at S phase entry"/>
            <pathway-xref db="Reactome" id="R-SPO-72649" name="Translation initiation complex formation"/>
            <pathway-xref db="Reactome" id="R-MMU-5668599" name="RHO GTPases Activate NADPH Oxidases"/>
            <pathway-xref db="Reactome" id="R-HSA-1362277" name="Transcription of E2F targets under negative control by DREAM complex"/>
            <pathway-xref db="Reactome" id="R-GGA-9648025" name="EML4 and NUDC in mitotic spindle formation"/>
            <pathway-xref db="Reactome" id="R-RNO-6804758" name="Regulation of TP53 Activity through Acetylation"/>
            <pathway-xref db="Reactome" id="R-MMU-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-6781827" name="Transcription-Coupled Nucleotide Excision Repair (TC-NER)"/>
            <pathway-xref db="Reactome" id="R-RNO-3108214" name="SUMOylation of DNA damage response and repair proteins"/>
            <pathway-xref db="Reactome" id="R-MMU-9707564" name="Cytoprotection by HMOX1"/>
            <pathway-xref db="Reactome" id="R-RNO-1660516" name="Synthesis of PIPs at the early endosome membrane"/>
            <pathway-xref db="Reactome" id="R-MMU-69231" name="Cyclin D associated events in G1"/>
            <pathway-xref db="Reactome" id="R-HSA-1257604" name="PIP3 activates AKT signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-5610787" name="Hedgehog 'off' state"/>
            <pathway-xref db="Reactome" id="R-HSA-163615" name="PKA activation"/>
            <pathway-xref db="Reactome" id="R-DME-416482" name="G alpha (12/13) signalling events"/>
            <pathway-xref db="Reactome" id="R-DME-3214858" name="RMTs methylate histone arginines"/>
            <pathway-xref db="Reactome" id="R-SPO-6811434" name="COPI-dependent Golgi-to-ER retrograde traffic"/>
            <pathway-xref db="Reactome" id="R-MMU-5610787" name="Hedgehog 'off' state"/>
            <pathway-xref db="Reactome" id="R-DDI-6782210" name="Gap-filling DNA repair synthesis and ligation in TC-NER"/>
            <pathway-xref db="Reactome" id="R-MMU-1257604" name="PIP3 activates AKT signaling"/>
            <pathway-xref db="Reactome" id="R-DME-4641265" name="Repression of WNT target genes"/>
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        </signature>
        <model-ac>PF12894</model-ac>
        <locations>
          <hmmer3-location env-end="285" env-start="197" post-processed="true" score="22.7" evalue="8.9E-5" hmm-start="10" hmm-end="90" hmm-length="92" hmm-bounds="INCOMPLETE" start="203" end="283">
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        </locations>
      </hmmer3-match>
      <hmmer3-match evalue="2.9E-7" score="31.1">
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            <pathway-xref db="Reactome" id="R-HSA-427389" name="ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression"/>
            <pathway-xref db="Reactome" id="R-RNO-389357" name="CD28 dependent PI3K/Akt signaling"/>
            <pathway-xref db="Reactome" id="R-SPO-6804757" name="Regulation of TP53 Degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-166208" name="mTORC1-mediated signalling"/>
            <pathway-xref db="Reactome" id="R-HSA-9020702" name="Interleukin-1 signaling"/>
            <pathway-xref db="Reactome" id="R-DDI-674695" name="RNA Polymerase II Pre-transcription Events"/>
            <pathway-xref db="Reactome" id="R-SCE-8856828" name="Clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-HSA-3371497" name="HSP90 chaperone cycle for steroid hormone receptors (SHR)"/>
            <pathway-xref db="Reactome" id="R-SSC-174178" name="APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1"/>
            <pathway-xref db="Reactome" id="R-GGA-2559580" name="Oxidative Stress Induced Senescence"/>
            <pathway-xref db="Reactome" id="R-DRE-380259" name="Loss of Nlp from mitotic centrosomes"/>
            <pathway-xref db="Reactome" id="R-SSC-174048" name="APC/C:Cdc20 mediated degradation of Cyclin B"/>
            <pathway-xref db="Reactome" id="R-GGA-6791226" name="Major pathway of rRNA processing in the nucleolus and cytosol"/>
            <pathway-xref db="Reactome" id="R-DDI-6804757" name="Regulation of TP53 Degradation"/>
            <pathway-xref db="Reactome" id="R-CFA-392451" name="G beta:gamma signalling through PI3Kgamma"/>
            <pathway-xref db="Reactome" id="R-MMU-3214815" name="HDACs deacetylate histones"/>
            <pathway-xref db="Reactome" id="R-SPO-204005" name="COPII-mediated vesicle transport"/>
            <pathway-xref db="Reactome" id="R-MMU-2559584" name="Formation of Senescence-Associated Heterochromatin Foci (SAHF)"/>
            <pathway-xref db="Reactome" id="R-MMU-8953750" name="Transcriptional Regulation by E2F6"/>
            <pathway-xref db="Reactome" id="R-XTR-212300" name="PRC2 methylates histones and DNA"/>
            <pathway-xref db="Reactome" id="R-MMU-9013420" name="RHOU GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DRE-416476" name="G alpha (q) signalling events"/>
            <pathway-xref db="Reactome" id="R-DRE-5674135" name="MAP2K and MAPK activation"/>
            <pathway-xref db="Reactome" id="R-SSC-176409" name="APC/C:Cdc20 mediated degradation of mitotic proteins"/>
            <pathway-xref db="Reactome" id="R-DDI-6791226" name="Major pathway of rRNA processing in the nucleolus and cytosol"/>
            <pathway-xref db="Reactome" id="R-MMU-72165" name="mRNA Splicing - Minor Pathway"/>
            <pathway-xref db="Reactome" id="R-MMU-212300" name="PRC2 methylates histones and DNA"/>
            <pathway-xref db="Reactome" id="R-DME-380972" name="Energy dependent regulation of mTOR by LKB1-AMPK"/>
            <pathway-xref db="Reactome" id="R-MMU-418555" name="G alpha (s) signalling events"/>
            <pathway-xref db="Reactome" id="R-DDI-9013404" name="RAC2 GTPase cycle"/>
          </entry>
          <signature-library-release library="PFAM" version="34.0"/>
        </signature>
        <model-ac>PF00400</model-ac>
        <locations>
          <hmmer3-location env-end="164" env-start="127" post-processed="true" score="22.9" evalue="1.1E-4" hmm-start="6" hmm-end="38" hmm-length="38" hmm-bounds="C_TERMINAL_COMPLETE" start="131" end="164">
            <location-fragments>
              <hmmer3-location-fragment start="131" end="164" dc-status="CONTINUOUS"/>
            </location-fragments>
          </hmmer3-location>
        </locations>
      </hmmer3-match>
      <hmmer3-match evalue="3.3E-29" score="102.1">
        <signature ac="PF00083" desc="Sugar (and other) transporter" name="Sugar_tr">
          <entry ac="IPR005828" desc="Major facilitator,  sugar transporter-like" name="MFS_sugar_transport-like" type="FAMILY">
            <go-xref category="BIOLOGICAL_PROCESS" db="GO" id="GO:0055085" name="transmembrane transport"/>
            <go-xref category="CELLULAR_COMPONENT" db="GO" id="GO:0016021" name="integral component of membrane"/>
            <go-xref category="MOLECULAR_FUNCTION" db="GO" id="GO:0022857" name="transmembrane transporter activity"/>
            <pathway-xref db="Reactome" id="R-HSA-189200" name="Cellular hexose transport"/>
            <pathway-xref db="Reactome" id="R-HSA-5619047" name="Defective SLC2A9 causes hypouricemia renal 2 (RHUC2)"/>
            <pathway-xref db="Reactome" id="R-MMU-181430" name="Norepinephrine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-2161517" name="Abacavir transmembrane transport"/>
            <pathway-xref db="Reactome" id="R-HSA-5653890" name="Lactose synthesis"/>
            <pathway-xref db="Reactome" id="R-DME-8981373" name="Intestinal hexose absorption"/>
            <pathway-xref db="Reactome" id="R-SCE-8981373" name="Intestinal hexose absorption"/>
            <pathway-xref db="Reactome" id="R-HSA-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-SSC-422356" name="Regulation of insulin secretion"/>
            <pathway-xref db="Reactome" id="R-MMU-112311" name="Neurotransmitter clearance"/>
            <pathway-xref db="Reactome" id="R-HSA-9022699" name="MECP2 regulates neuronal receptors and channels"/>
            <pathway-xref db="Reactome" id="R-BTA-189200" name="Cellular hexose transport"/>
            <pathway-xref db="Reactome" id="R-RNO-189200" name="Cellular hexose transport"/>
            <pathway-xref db="Reactome" id="R-BTA-181430" name="Norepinephrine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-561048" name="Organic anion transport"/>
            <pathway-xref db="Reactome" id="R-HSA-561048" name="Organic anion transport"/>
            <pathway-xref db="Reactome" id="R-MMU-200425" name="Carnitine metabolism"/>
            <pathway-xref db="Reactome" id="R-HSA-917937" name="Iron uptake and transport"/>
            <pathway-xref db="Reactome" id="R-MMU-197264" name="Nicotinamide salvaging"/>
            <pathway-xref db="Reactome" id="R-HSA-8856828" name="Clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-HSA-5250992" name="Toxicity of botulinum toxin type E (botE)"/>
            <pathway-xref db="Reactome" id="R-HSA-8981373" name="Intestinal hexose absorption"/>
            <pathway-xref db="Reactome" id="R-HSA-5250968" name="Toxicity of botulinum toxin type A (botA)"/>
            <pathway-xref db="Reactome" id="R-MMU-549127" name="Organic cation transport"/>
            <pathway-xref db="Reactome" id="R-RNO-442660" name="Na+/Cl- dependent neurotransmitter transporters"/>
            <pathway-xref db="Reactome" id="R-CEL-422356" name="Regulation of insulin secretion"/>
            <pathway-xref db="Reactome" id="R-DME-422356" name="Regulation of insulin secretion"/>
            <pathway-xref db="Reactome" id="R-HSA-112311" name="Neurotransmitter clearance"/>
            <pathway-xref db="Reactome" id="R-HSA-5619071" name="Defective SLC22A12 causes renal hypouricemia 1 (RHUC1)"/>
            <pathway-xref db="Reactome" id="R-RNO-196836" name="Vitamin C (ascorbate) metabolism"/>
            <pathway-xref db="Reactome" id="R-MMU-189200" name="Cellular hexose transport"/>
            <pathway-xref db="Reactome" id="R-SCE-422356" name="Regulation of insulin secretion"/>
            <pathway-xref db="Reactome" id="R-HSA-181430" name="Norepinephrine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-561048" name="Organic anion transport"/>
            <pathway-xref db="Reactome" id="R-DME-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-SSC-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-HSA-381340" name="Transcriptional regulation of white adipocyte differentiation"/>
            <pathway-xref db="Reactome" id="R-RNO-200425" name="Carnitine metabolism"/>
            <pathway-xref db="Reactome" id="R-MMU-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-HSA-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-SCE-429593" name="Inositol transporters"/>
            <pathway-xref db="Reactome" id="R-SSC-8981373" name="Intestinal hexose absorption"/>
            <pathway-xref db="Reactome" id="R-RNO-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-CEL-8981373" name="Intestinal hexose absorption"/>
            <pathway-xref db="Reactome" id="R-CEL-429593" name="Inositol transporters"/>
            <pathway-xref db="Reactome" id="R-MMU-5653890" name="Lactose synthesis"/>
            <pathway-xref db="Reactome" id="R-BTA-442660" name="Na+/Cl- dependent neurotransmitter transporters"/>
            <pathway-xref db="Reactome" id="R-XTR-189200" name="Cellular hexose transport"/>
            <pathway-xref db="Reactome" id="R-MMU-8856828" name="Clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-HSA-549127" name="Organic cation transport"/>
            <pathway-xref db="Reactome" id="R-HSA-5619068" name="Defective SLC2A10 causes arterial tortuosity syndrome (ATS)"/>
            <pathway-xref db="Reactome" id="R-RNO-8981373" name="Intestinal hexose absorption"/>
            <pathway-xref db="Reactome" id="R-SSC-196836" name="Vitamin C (ascorbate) metabolism"/>
            <pathway-xref db="Reactome" id="R-HSA-422356" name="Regulation of insulin secretion"/>
            <pathway-xref db="Reactome" id="R-HSA-429593" name="Inositol transporters"/>
            <pathway-xref db="Reactome" id="R-HSA-200425" name="Carnitine metabolism"/>
            <pathway-xref db="Reactome" id="R-SPO-429593" name="Inositol transporters"/>
            <pathway-xref db="Reactome" id="R-GGA-352832" name="Glucose transport"/>
            <pathway-xref db="Reactome" id="R-HSA-197264" name="Nicotinamide salvaging"/>
            <pathway-xref db="Reactome" id="R-MMU-196836" name="Vitamin C (ascorbate) metabolism"/>
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            <pathway-xref db="Reactome" id="R-CEL-6798695" name="Neutrophil degranulation"/>
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            <pathway-xref db="Reactome" id="R-BTA-2161517" name="Abacavir transmembrane transport"/>
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            <pathway-xref db="Reactome" id="R-RNO-549127" name="Organic cation transport"/>
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            <pathway-xref db="Reactome" id="R-CEL-197264" name="Nicotinamide salvaging"/>
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            <pathway-xref db="Reactome" id="R-CEL-200425" name="Carnitine metabolism"/>
            <pathway-xref db="Reactome" id="R-HSA-1445148" name="Translocation of SLC2A4 (GLUT4) to the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-RNO-429593" name="Inositol transporters"/>
            <pathway-xref db="Reactome" id="R-RNO-422356" name="Regulation of insulin secretion"/>
            <pathway-xref db="Reactome" id="R-RNO-917937" name="Iron uptake and transport"/>
            <pathway-xref db="Reactome" id="R-HSA-5619043" name="Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1)"/>
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            <pathway-xref db="Reactome" id="R-DME-561048" name="Organic anion transport"/>
            <pathway-xref db="Reactome" id="R-MMU-429593" name="Inositol transporters"/>
            <pathway-xref db="Reactome" id="R-DME-197264" name="Nicotinamide salvaging"/>
            <pathway-xref db="Reactome" id="R-SCE-5653890" name="Lactose synthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-549127" name="Organic cation transport"/>
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            <pathway-xref db="Reactome" id="R-RNO-5653890" name="Lactose synthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-442660" name="Na+/Cl- dependent neurotransmitter transporters"/>
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            <pathway-xref db="Reactome" id="R-RNO-112311" name="Neurotransmitter clearance"/>
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            <pathway-xref db="Reactome" id="R-SSC-561048" name="Organic anion transport"/>
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            <pathway-xref db="Reactome" id="R-SCE-189200" name="Cellular hexose transport"/>
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            <pathway-xref db="Reactome" id="R-RNO-2161517" name="Abacavir transmembrane transport"/>
            <pathway-xref db="Reactome" id="R-HSA-196836" name="Vitamin C (ascorbate) metabolism"/>
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          <signature-library-release library="PFAM" version="34.0"/>
        </signature>
        <model-ac>PF00083</model-ac>
        <locations>
          <hmmer3-location env-end="1402" env-start="973" post-processed="true" score="101.4" evalue="5.0E-29" hmm-start="50" hmm-end="445" hmm-length="452" hmm-bounds="INCOMPLETE" start="1021" end="1396">
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              <hmmer3-location-fragment start="1021" end="1396" dc-status="CONTINUOUS"/>
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          </hmmer3-location>
        </locations>
      </hmmer3-match>
      <hmmer3-match evalue="5.0E-26" score="93.7">
        <signature ac="G3DSA:2.130.10.10" name="">
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            <pathway-xref db="Reactome" id="R-SPO-75955" name="RNA Polymerase II Transcription Elongation"/>
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            <pathway-xref db="Reactome" id="R-SCE-76061" name="RNA Polymerase III Transcription Initiation From Type 1 Promoter"/>
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            <pathway-xref db="Reactome" id="R-MMU-72163" name="mRNA Splicing - Major Pathway"/>
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            <pathway-xref db="Reactome" id="R-BTA-606279" name="Deposition of new CENPA-containing nucleosomes at the centromere"/>
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            <pathway-xref db="Reactome" id="R-MMU-9615933" name="Postmitotic nuclear pore complex (NPC) reformation"/>
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            <pathway-xref db="Reactome" id="R-MMU-1655829" name="Regulation of cholesterol biosynthesis by SREBP (SREBF)"/>
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            <pathway-xref db="Reactome" id="R-CEL-381753" name="Olfactory Signaling Pathway"/>
            <pathway-xref db="Reactome" id="R-DME-72187" name="mRNA 3'-end processing"/>
            <pathway-xref db="Reactome" id="R-CEL-204005" name="COPII-mediated vesicle transport"/>
            <pathway-xref db="Reactome" id="R-SCE-69656" name="Cyclin A:Cdk2-associated events at S phase entry"/>
            <pathway-xref db="Reactome" id="R-MMU-8943724" name="Regulation of PTEN gene transcription"/>
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            <pathway-xref db="Reactome" id="R-MMU-69656" name="Cyclin A:Cdk2-associated events at S phase entry"/>
            <pathway-xref db="Reactome" id="R-HSA-5173214" name="O-glycosylation of TSR domain-containing proteins"/>
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            <pathway-xref db="Reactome" id="R-HSA-1257604" name="PIP3 activates AKT signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-8293" name="alazopeptin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-5610787" name="Hedgehog 'off' state"/>
            <pathway-xref db="Reactome" id="R-HSA-163615" name="PKA activation"/>
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        </signature>
        <model-ac>4i79A00</model-ac>
        <locations>
          <hmmer3-location env-end="319" env-start="197" post-processed="true" score="25.9" evalue="2.2E-5" hmm-start="125" hmm-end="205" hmm-length="341" hmm-bounds="COMPLETE" start="197" end="319">
            <location-fragments>
              <hmmer3-location-fragment start="197" end="319" dc-status="CONTINUOUS"/>
            </location-fragments>
          </hmmer3-location>
        </locations>
      </hmmer3-match>
      <hmmer3-match evalue="8.4E-71" score="241.1">
        <signature ac="G3DSA:1.20.1250.20" name="MFS general substrate transporter like domains">
          <entry ac="IPR036259" desc="MFS transporter superfamily" name="MFS_trans_sf" type="HOMOLOGOUS_SUPERFAMILY">
            <pathway-xref db="Reactome" id="R-CEL-210500" name="Glutamate Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-GGA-373920" name="Pyruvate metabolism"/>
            <pathway-xref db="Reactome" id="R-RNO-425397" name="Transport of vitamins, nucleosides, and related molecules"/>
            <pathway-xref db="Reactome" id="R-MMU-181430" name="Norepinephrine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-879518" name="Transport of organic anions"/>
            <pathway-xref db="Reactome" id="R-SPO-442380" name="Zinc influx into cells by the SLC39 gene family"/>
            <pathway-xref db="Reactome" id="R-MMU-2161517" name="Abacavir transmembrane transport"/>
            <pathway-xref db="Reactome" id="R-HSA-352230" name="Amino acid transport across the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-HSA-5653890" name="Lactose synthesis"/>
            <pathway-xref db="Reactome" id="R-SCE-8981373" name="Intestinal hexose absorption"/>
            <pathway-xref db="Reactome" id="R-HSA-427975" name="Proton/oligopeptide cotransporters"/>
            <pathway-xref db="Reactome" id="R-HSA-5655799" name="Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum)"/>
            <pathway-xref db="Reactome" id="R-RNO-425410" name="Metal ion SLC transporters"/>
            <pathway-xref db="Reactome" id="R-CEL-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-HSA-196819" name="Vitamin B1 (thiamin) metabolism"/>
            <pathway-xref db="Reactome" id="R-HSA-428643" name="Organic anion transporters"/>
            <pathway-xref db="Reactome" id="R-RNO-196757" name="Metabolism of folate and pterines"/>
            <pathway-xref db="Reactome" id="R-CEL-4085001" name="Sialic acid metabolism"/>
            <pathway-xref db="Reactome" id="R-DRE-352230" name="Amino acid transport across the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-BTA-352230" name="Amino acid transport across the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-DRE-427975" name="Proton/oligopeptide cotransporters"/>
            <pathway-xref db="Reactome" id="R-RNO-189200" name="Cellular hexose transport"/>
            <pathway-xref db="Reactome" id="R-BTA-181430" name="Norepinephrine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-70268" name="Pyruvate metabolism"/>
            <pathway-xref db="Reactome" id="R-DRE-1483191" name="Synthesis of PC"/>
            <pathway-xref db="Reactome" id="R-DDI-196757" name="Metabolism of folate and pterines"/>
            <pathway-xref db="Reactome" id="R-RNO-159418" name="Recycling of bile acids and salts"/>
            <pathway-xref db="Reactome" id="R-HSA-561048" name="Organic anion transport"/>
            <pathway-xref db="Reactome" id="R-MMU-200425" name="Carnitine metabolism"/>
            <pathway-xref db="Reactome" id="R-CEL-264642" name="Acetylcholine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-SPO-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-MMU-9707616" name="Heme signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-5619049" name="Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages)"/>
            <pathway-xref db="Reactome" id="R-BTA-428643" name="Organic anion transporters"/>
            <pathway-xref db="Reactome" id="R-RNO-433692" name="Proton-coupled monocarboxylate transport"/>
            <pathway-xref db="Reactome" id="R-DRE-428643" name="Organic anion transporters"/>
            <pathway-xref db="Reactome" id="R-DME-422356" name="Regulation of insulin secretion"/>
            <pathway-xref db="Reactome" id="R-CEL-196757" name="Metabolism of folate and pterines"/>
            <pathway-xref db="MetaCyc" id="PWY-7975" name="adenosylcobalamin biosynthesis from adenosylcobinamide-GDP II"/>
            <pathway-xref db="Reactome" id="R-DRE-8856828" name="Clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-HSA-181430" name="Norepinephrine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-5619095" name="Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2)"/>
            <pathway-xref db="Reactome" id="R-MMU-352230" name="Amino acid transport across the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-SPO-8856828" name="Clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-MMU-561048" name="Organic anion transport"/>
            <pathway-xref db="Reactome" id="R-DRE-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-DME-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-RNO-210500" name="Glutamate Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-SPO-425397" name="Transport of vitamins, nucleosides, and related molecules"/>
            <pathway-xref db="Reactome" id="R-MMU-212676" name="Dopamine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-XTR-1483191" name="Synthesis of PC"/>
            <pathway-xref db="Reactome" id="R-SPO-917937" name="Iron uptake and transport"/>
            <pathway-xref db="Reactome" id="R-SCE-429593" name="Inositol transporters"/>
            <pathway-xref db="Reactome" id="R-HSA-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-SPO-879518" name="Transport of organic anions"/>
            <pathway-xref db="Reactome" id="R-SSC-8981373" name="Intestinal hexose absorption"/>
            <pathway-xref db="Reactome" id="R-SPO-196757" name="Metabolism of folate and pterines"/>
            <pathway-xref db="MetaCyc" id="PWY-6322" name="phosphinothricin tripeptide biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-8981373" name="Intestinal hexose absorption"/>
            <pathway-xref db="Reactome" id="R-CEL-429593" name="Inositol transporters"/>
            <pathway-xref db="Reactome" id="R-MMU-5653890" name="Lactose synthesis"/>
            <pathway-xref db="Reactome" id="R-SPO-181429" name="Serotonin Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-264642" name="Acetylcholine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-BTA-442660" name="Na+/Cl- dependent neurotransmitter transporters"/>
            <pathway-xref db="Reactome" id="R-XTR-189200" name="Cellular hexose transport"/>
            <pathway-xref db="Reactome" id="R-HSA-70263" name="Gluconeogenesis"/>
            <pathway-xref db="Reactome" id="R-HSA-5662702" name="Melanin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-549127" name="Organic cation transport"/>
            <pathway-xref db="Reactome" id="R-HSA-210991" name="Basigin interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-5619110" name="Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR)"/>
            <pathway-xref db="Reactome" id="R-XTR-210500" name="Glutamate Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-422356" name="Regulation of insulin secretion"/>
            <pathway-xref db="Reactome" id="R-HSA-429593" name="Inositol transporters"/>
            <pathway-xref db="Reactome" id="R-SPO-429593" name="Inositol transporters"/>
            <pathway-xref db="Reactome" id="R-GGA-352832" name="Glucose transport"/>
            <pathway-xref db="Reactome" id="R-HSA-1660661" name="Sphingolipid de novo biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-5619061" name="Defective SLC33A1 causes spastic paraplegia 42 (SPG42)"/>
            <pathway-xref db="Reactome" id="R-DME-879518" name="Transport of organic anions"/>
            <pathway-xref db="Reactome" id="R-MMU-210500" name="Glutamate Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-210991" name="Basigin interactions"/>
            <pathway-xref db="Reactome" id="R-BTA-549127" name="Organic cation transport"/>
            <pathway-xref db="Reactome" id="R-HSA-351906" name="Apoptotic cleavage of cell adhesion proteins"/>
            <pathway-xref db="Reactome" id="R-MMU-442660" name="Na+/Cl- dependent neurotransmitter transporters"/>
            <pathway-xref db="Reactome" id="R-RNO-212676" name="Dopamine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-SCE-196836" name="Vitamin C (ascorbate) metabolism"/>
            <pathway-xref db="Reactome" id="R-CEL-197264" name="Nicotinamide salvaging"/>
            <pathway-xref db="MetaCyc" id="PWY-7740" name="beta-D-mannosyl phosphomycoketide biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-200425" name="Carnitine metabolism"/>
            <pathway-xref db="Reactome" id="R-SPO-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-RNO-429593" name="Inositol transporters"/>
            <pathway-xref db="Reactome" id="R-RNO-422356" name="Regulation of insulin secretion"/>
            <pathway-xref db="Reactome" id="R-MMU-427975" name="Proton/oligopeptide cotransporters"/>
            <pathway-xref db="Reactome" id="R-RNO-181429" name="Serotonin Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-917937" name="Iron uptake and transport"/>
            <pathway-xref db="Reactome" id="R-HSA-5619043" name="Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1)"/>
            <pathway-xref db="Reactome" id="R-HSA-5619060" name="Defective CP causes aceruloplasminemia (ACERULOP)"/>
            <pathway-xref db="Reactome" id="R-MMU-196757" name="Metabolism of folate and pterines"/>
            <pathway-xref db="Reactome" id="R-SCE-5653890" name="Lactose synthesis"/>
            <pathway-xref db="Reactome" id="R-SCE-352230" name="Amino acid transport across the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-HSA-264642" name="Acetylcholine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-8856828" name="Clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-RNO-181430" name="Norepinephrine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-DRE-425410" name="Metal ion SLC transporters"/>
            <pathway-xref db="Reactome" id="R-MMU-879518" name="Transport of organic anions"/>
            <pathway-xref db="MetaCyc" id="PWY-5129" name="sphingolipid biosynthesis (plants)"/>
            <pathway-xref db="Reactome" id="R-RNO-112311" name="Neurotransmitter clearance"/>
            <pathway-xref db="Reactome" id="R-HSA-5619053" name="Defective SLC22A5 causes systemic primary carnitine deficiency (CDSP)"/>
            <pathway-xref db="Reactome" id="R-DRE-1660661" name="Sphingolipid de novo biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-189483" name="Heme degradation"/>
            <pathway-xref db="Reactome" id="R-CEL-561048" name="Organic anion transport"/>
            <pathway-xref db="Reactome" id="R-HSA-5250955" name="Toxicity of botulinum toxin type D (botD)"/>
            <pathway-xref db="Reactome" id="R-MMU-196819" name="Vitamin B1 (thiamin) metabolism"/>
            <pathway-xref db="Reactome" id="R-RNO-9707616" name="Heme signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-1660661" name="Sphingolipid de novo biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9707616" name="Heme signaling"/>
            <pathway-xref db="Reactome" id="R-BTA-196757" name="Metabolism of folate and pterines"/>
            <pathway-xref db="MetaCyc" id="PWY-7886" name="cell-surface glycoconjugate-linked phosphocholine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SSC-561048" name="Organic anion transport"/>
            <pathway-xref db="Reactome" id="R-DME-189200" name="Cellular hexose transport"/>
            <pathway-xref db="Reactome" id="R-SPO-189200" name="Cellular hexose transport"/>
            <pathway-xref db="Reactome" id="R-HSA-2161517" name="Abacavir transmembrane transport"/>
            <pathway-xref db="Reactome" id="R-MMU-425397" name="Transport of vitamins, nucleosides, and related molecules"/>
            <pathway-xref db="Reactome" id="R-DRE-561048" name="Organic anion transport"/>
            <pathway-xref db="Reactome" id="R-SCE-189200" name="Cellular hexose transport"/>
            <pathway-xref db="Reactome" id="R-DME-8856828" name="Clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-RNO-2161517" name="Abacavir transmembrane transport"/>
            <pathway-xref db="Reactome" id="R-HSA-196836" name="Vitamin C (ascorbate) metabolism"/>
            <pathway-xref db="Reactome" id="R-HSA-189200" name="Cellular hexose transport"/>
            <pathway-xref db="Reactome" id="R-HSA-5619047" name="Defective SLC2A9 causes hypouricemia renal 2 (RHUC2)"/>
            <pathway-xref db="Reactome" id="R-HSA-196757" name="Metabolism of folate and pterines"/>
            <pathway-xref db="Reactome" id="R-SPO-9707616" name="Heme signaling"/>
            <pathway-xref db="Reactome" id="R-SPO-427975" name="Proton/oligopeptide cotransporters"/>
            <pathway-xref db="Reactome" id="R-SPO-352230" name="Amino acid transport across the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-BTA-879518" name="Transport of organic anions"/>
            <pathway-xref db="Reactome" id="R-HSA-425410" name="Metal ion SLC transporters"/>
            <pathway-xref db="Reactome" id="R-RNO-428643" name="Organic anion transporters"/>
            <pathway-xref db="Reactome" id="R-HSA-3229133" name="Glycogen storage disease type Ib (SLC37A4)"/>
            <pathway-xref db="Reactome" id="R-DME-8981373" name="Intestinal hexose absorption"/>
            <pathway-xref db="Reactome" id="R-DRE-83936" name="Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-SCE-83936" name="Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-HSA-425397" name="Transport of vitamins, nucleosides, and related molecules"/>
            <pathway-xref db="Reactome" id="R-HSA-879518" name="Transport of organic anions"/>
            <pathway-xref db="Reactome" id="R-SCE-9707616" name="Heme signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-SSC-422356" name="Regulation of insulin secretion"/>
            <pathway-xref db="Reactome" id="R-MMU-112311" name="Neurotransmitter clearance"/>
            <pathway-xref db="Reactome" id="R-HSA-159418" name="Recycling of bile acids and salts"/>
            <pathway-xref db="Reactome" id="R-SCE-425397" name="Transport of vitamins, nucleosides, and related molecules"/>
            <pathway-xref db="Reactome" id="R-DDI-196819" name="Vitamin B1 (thiamin) metabolism"/>
            <pathway-xref db="Reactome" id="R-HSA-5619076" name="Defective SLC17A8 causes autosomal dominant deafness 25 (DFNA25)"/>
            <pathway-xref db="Reactome" id="R-SPO-442660" name="Na+/Cl- dependent neurotransmitter transporters"/>
            <pathway-xref db="Reactome" id="R-DME-264642" name="Acetylcholine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-9022699" name="MECP2 regulates neuronal receptors and channels"/>
            <pathway-xref db="Reactome" id="R-MMU-4085001" name="Sialic acid metabolism"/>
            <pathway-xref db="Reactome" id="R-BTA-189200" name="Cellular hexose transport"/>
            <pathway-xref db="Reactome" id="R-HSA-181429" name="Serotonin Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-2672351" name="Stimuli-sensing channels"/>
            <pathway-xref db="Reactome" id="R-RNO-561048" name="Organic anion transport"/>
            <pathway-xref db="Reactome" id="R-HSA-70268" name="Pyruvate metabolism"/>
            <pathway-xref db="Reactome" id="R-HSA-5619070" name="Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT)"/>
            <pathway-xref db="Reactome" id="R-HSA-917937" name="Iron uptake and transport"/>
            <pathway-xref db="Reactome" id="R-DRE-264642" name="Acetylcholine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-197264" name="Nicotinamide salvaging"/>
            <pathway-xref db="Reactome" id="R-HSA-8856828" name="Clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-HSA-5250992" name="Toxicity of botulinum toxin type E (botE)"/>
            <pathway-xref db="Reactome" id="R-HSA-433692" name="Proton-coupled monocarboxylate transport"/>
            <pathway-xref db="Reactome" id="R-HSA-8981373" name="Intestinal hexose absorption"/>
            <pathway-xref db="Reactome" id="R-HSA-189451" name="Heme biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-427975" name="Proton/oligopeptide cotransporters"/>
            <pathway-xref db="Reactome" id="R-HSA-5250968" name="Toxicity of botulinum toxin type A (botA)"/>
            <pathway-xref db="Reactome" id="R-MMU-549127" name="Organic cation transport"/>
            <pathway-xref db="Reactome" id="R-RNO-442660" name="Na+/Cl- dependent neurotransmitter transporters"/>
            <pathway-xref db="Reactome" id="R-CEL-422356" name="Regulation of insulin secretion"/>
            <pathway-xref db="Reactome" id="R-HSA-112311" name="Neurotransmitter clearance"/>
            <pathway-xref db="Reactome" id="R-HSA-5619071" name="Defective SLC22A12 causes renal hypouricemia 1 (RHUC1)"/>
            <pathway-xref db="Reactome" id="R-RNO-196836" name="Vitamin C (ascorbate) metabolism"/>
            <pathway-xref db="Reactome" id="R-SCE-422356" name="Regulation of insulin secretion"/>
            <pathway-xref db="Reactome" id="R-MMU-189200" name="Cellular hexose transport"/>
            <pathway-xref db="Reactome" id="R-HSA-5619035" name="Defective SLC17A5 causes Salla disease (SD) and ISSD"/>
            <pathway-xref db="Reactome" id="R-MMU-1483191" name="Synthesis of PC"/>
            <pathway-xref db="Reactome" id="R-XTR-352230" name="Amino acid transport across the plasma membrane"/>
            <pathway-xref db="MetaCyc" id="PWY-6955" name="lincomycin A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DRE-196757" name="Metabolism of folate and pterines"/>
            <pathway-xref db="Reactome" id="R-MMU-425410" name="Metal ion SLC transporters"/>
            <pathway-xref db="Reactome" id="R-SSC-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="MetaCyc" id="PWY-7769" name="phosalacine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-200425" name="Carnitine metabolism"/>
            <pathway-xref db="Reactome" id="R-HSA-381340" name="Transcriptional regulation of white adipocyte differentiation"/>
            <pathway-xref db="Reactome" id="R-HSA-8935964" name="RUNX1 regulates expression of components of tight junctions"/>
            <pathway-xref db="Reactome" id="R-CEL-428643" name="Organic anion transporters"/>
            <pathway-xref db="Reactome" id="R-MMU-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-RNO-427975" name="Proton/oligopeptide cotransporters"/>
            <pathway-xref db="Reactome" id="R-DRE-9707616" name="Heme signaling"/>
            <pathway-xref db="Reactome" id="R-SCE-879518" name="Transport of organic anions"/>
            <pathway-xref db="Reactome" id="R-DME-1660661" name="Sphingolipid de novo biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7077" name="N-acetyl-D-galactosamine degradation"/>
            <pathway-xref db="Reactome" id="R-SCE-196757" name="Metabolism of folate and pterines"/>
            <pathway-xref db="Reactome" id="R-HSA-4085001" name="Sialic acid metabolism"/>
            <pathway-xref db="Reactome" id="R-MMU-70263" name="Gluconeogenesis"/>
            <pathway-xref db="Reactome" id="R-SCE-917937" name="Iron uptake and transport"/>
            <pathway-xref db="Reactome" id="R-CEL-196819" name="Vitamin B1 (thiamin) metabolism"/>
            <pathway-xref db="Reactome" id="R-RNO-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-MMU-8856828" name="Clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-DRE-70263" name="Gluconeogenesis"/>
            <pathway-xref db="Reactome" id="R-DRE-917937" name="Iron uptake and transport"/>
            <pathway-xref db="Reactome" id="R-RNO-189483" name="Heme degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-9662360" name="Sensory processing of sound by inner hair cells of the cochlea"/>
            <pathway-xref db="MetaCyc" id="PWY-6369" name="inositol diphosphates biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-5619068" name="Defective SLC2A10 causes arterial tortuosity syndrome (ATS)"/>
            <pathway-xref db="Reactome" id="R-RNO-8981373" name="Intestinal hexose absorption"/>
            <pathway-xref db="Reactome" id="R-MMU-83936" name="Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-SSC-196836" name="Vitamin C (ascorbate) metabolism"/>
            <pathway-xref db="Reactome" id="R-HSA-200425" name="Carnitine metabolism"/>
            <pathway-xref db="Reactome" id="R-MMU-433692" name="Proton-coupled monocarboxylate transport"/>
            <pathway-xref db="Reactome" id="R-XTR-70263" name="Gluconeogenesis"/>
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            <pathway-xref db="Reactome" id="R-RNO-70268" name="Pyruvate metabolism"/>
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          <signature-library-release library="PROSITE_PATTERNS" version="2021_01"/>
        </signature>
        <model-ac>PS00678</model-ac>
        <locations>
          <patternscan-location level="STRONG" start="151" end="165">
            <location-fragments>
              <patternscan-location-fragment start="151" end="165" dc-status="CONTINUOUS"/>
            </location-fragments>
            <alignment>VTSSsaDgSIRVWNI</alignment>
          </patternscan-location>
        </locations>
      </patternscan-match>
      <profilescan-match>
        <signature ac="PS50082" desc="Trp-Asp (WD) repeats profile." name="WD_REPEATS_2">
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          <signature-library-release library="PROSITE_PROFILES" version="2021_01"/>
        </signature>
        <model-ac>PS50082</model-ac>
        <locations>
          <profilescan-location score="15.387508" start="132" end="173">
            <location-fragments>
              <profilescan-location-fragment start="132" end="173" dc-status="CONTINUOUS"/>
            </location-fragments>
            <alignment>LEGHGAPILGLSLDPKEEFVTSSSADGSIRVWNIKEKKTVHV</alignment>
          </profilescan-location>
        </locations>
      </profilescan-match>
      <profilescan-match>
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            <pathway-xref db="Reactome" id="R-MMU-264642" name="Acetylcholine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-1445148" name="Translocation of SLC2A4 (GLUT4) to the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-HSA-212676" name="Dopamine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-210991" name="Basigin interactions"/>
            <pathway-xref db="Reactome" id="R-MMU-159418" name="Recycling of bile acids and salts"/>
            <pathway-xref db="Reactome" id="R-SCE-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-DME-561048" name="Organic anion transport"/>
            <pathway-xref db="Reactome" id="R-MMU-429593" name="Inositol transporters"/>
            <pathway-xref db="Reactome" id="R-DME-197264" name="Nicotinamide salvaging"/>
            <pathway-xref db="Reactome" id="R-BTA-917937" name="Iron uptake and transport"/>
            <pathway-xref db="Reactome" id="R-CEL-549127" name="Organic cation transport"/>
            <pathway-xref db="Reactome" id="R-CEL-189200" name="Cellular hexose transport"/>
            <pathway-xref db="Reactome" id="R-HSA-210500" name="Glutamate Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-5653890" name="Lactose synthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-442660" name="Na+/Cl- dependent neurotransmitter transporters"/>
            <pathway-xref db="Reactome" id="R-BTA-112311" name="Neurotransmitter clearance"/>
            <pathway-xref db="Reactome" id="R-HSA-5619058" name="Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR)"/>
            <pathway-xref db="Reactome" id="R-XTR-428643" name="Organic anion transporters"/>
            <pathway-xref db="Reactome" id="R-DME-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-RNO-352230" name="Amino acid transport across the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-RNO-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-MMU-917937" name="Iron uptake and transport"/>
            <pathway-xref db="Reactome" id="R-SSC-189200" name="Cellular hexose transport"/>
            <pathway-xref db="Reactome" id="R-MMU-8981373" name="Intestinal hexose absorption"/>
            <pathway-xref db="Reactome" id="R-MMU-422356" name="Regulation of insulin secretion"/>
            <pathway-xref db="Reactome" id="R-SPO-212676" name="Dopamine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-428643" name="Organic anion transporters"/>
            <pathway-xref db="Reactome" id="R-DRE-189200" name="Cellular hexose transport"/>
            <pathway-xref db="Reactome" id="R-CEL-8856828" name="Clathrin-mediated endocytosis"/>
          </entry>
          <signature-library-release library="PROSITE_PROFILES" version="2021_01"/>
        </signature>
        <model-ac>PS50850</model-ac>
        <locations>
          <profilescan-location score="21.097012" start="959" end="1393">
            <location-fragments>
              <profilescan-location-fragment start="959" end="1393" dc-status="CONTINUOUS"/>
            </location-fragments>
            <alignment>PTNFSCIAPLSATNDSTIMkceidvgngtmekctdfkydkRIFRESIITQWNLVCdkeQLANFAQSCTMFGVLIGNLIFSVMADRIGRKKPLMIAIALQSVTGFASAFAPWYELFXILKFICALATGGTMLVSFVLLMEIIGIEWRSIMSVL----FHVPFLLGHLMNPLISylTHGTWSG-FQMAVSIPSVFLLAYYWIIPESPRWllamgkprqaERILLKAAERNKIPVENVKVALETHEnqaairitkskekynithlfrtpnLRLKTICVSINWFV--CGMCFFGLAQYMGH--LDGDIFINVAVSAAME----LPGTVIVLFLISRVSRLKILIGGNILSGVSLLLITLMTNA---SARIFLASLGLVGMAISFPTIYLYSGEVFPTVVRNIGVGLGSISARIGSIIAPYIATMG----TIQPwlPPVIFAIGPMLGAVLCLLLPETMN</alignment>
          </profilescan-location>
        </locations>
      </profilescan-match>
      <profilescan-match>
        <signature ac="PS50294" desc="Trp-Asp (WD) repeats circular profile." name="WD_REPEATS_REGION">
          <signature-library-release library="PROSITE_PROFILES" version="2021_01"/>
        </signature>
        <model-ac>PS50294</model-ac>
        <locations>
          <profilescan-location score="11.65559" start="132" end="166">
            <location-fragments>
              <profilescan-location-fragment start="132" end="166" dc-status="CONTINUOUS"/>
            </location-fragments>
            <alignment>LEGHGAPILGLSLDPKEEFVTSSSADGSIRVWNIK-------</alignment>
          </profilescan-location>
        </locations>
      </profilescan-match>
      <rpsblast-match>
        <signature ac="cd00084" desc="HMG-box" name="HMG-box">
          <signature-library-release library="CDD" version="3.18"/>
        </signature>
        <model-ac>cd00084</model-ac>
        <locations>
          <rpsblast-location evalue="0.00548505" score="34.902" start="842" end="893">
            <location-fragments>
              <rpsblast-location-fragment start="842" end="893" dc-status="CONTINUOUS"/>
            </location-fragments>
            <sites>
              <rpsblast-site description="DNA binding site" numLocations="12">
                <site-locations>
                  <site-location residue="Y" start="860" end="860"/>
                  <site-location residue="R" start="864" end="864"/>
                  <site-location residue="V" start="857" end="857"/>
                  <site-location residue="Y" start="887" end="887"/>
                  <site-location residue="S" start="847" end="847"/>
                  <site-location residue="Q" start="868" end="868"/>
                  <site-location residue="K" start="846" end="846"/>
                  <site-location residue="K" start="881" end="881"/>
                  <site-location residue="F" start="856" end="856"/>
                  <site-location residue="A" start="861" end="861"/>
                  <site-location residue="K" start="844" end="844"/>
                  <site-location residue="L" start="884" end="884"/>
                </site-locations>
              </rpsblast-site>
            </sites>
          </rpsblast-location>
        </locations>
      </rpsblast-match>
      <rpsblast-match>
        <signature ac="cd17317" desc="MFS_SLC22" name="MFS_SLC22">
          <signature-library-release library="CDD" version="3.18"/>
        </signature>
        <model-ac>cd17317</model-ac>
        <locations>
          <rpsblast-location evalue="1.21069E-102" score="328.771" start="995" end="1389">
            <location-fragments>
              <rpsblast-location-fragment start="995" end="1389" dc-status="CONTINUOUS"/>
            </location-fragments>
            <sites>
              <rpsblast-site description="putative chemical substrate binding pocket" numLocations="35">
                <site-locations>
                  <site-location residue="N" start="1034" end="1034"/>
                  <site-location residue="S" start="1353" end="1353"/>
                  <site-location residue="T" start="1084" end="1084"/>
                  <site-location residue="S" start="1108" end="1108"/>
                  <site-location residue="T" start="1007" end="1007"/>
                  <site-location residue="G" start="1317" end="1317"/>
                  <site-location residue="H" start="1112" end="1112"/>
                  <site-location residue="R" start="1002" end="1002"/>
                  <site-location residue="Y" start="1326" end="1326"/>
                  <site-location residue="E" start="1003" end="1003"/>
                  <site-location residue="C" start="1235" end="1235"/>
                  <site-location residue="G" start="1236" end="1236"/>
                  <site-location residue="T" start="1268" end="1268"/>
                  <site-location residue="F" start="1111" end="1111"/>
                  <site-location residue="F" start="1239" end="1239"/>
                  <site-location residue="G" start="1085" end="1085"/>
                  <site-location residue="F" start="1322" end="1322"/>
                  <site-location residue="I" start="1006" end="1006"/>
                  <site-location residue="G" start="1345" end="1345"/>
                  <site-location residue="R" start="1350" end="1350"/>
                  <site-location residue="F" start="1092" end="1092"/>
                  <site-location residue="T" start="1087" end="1087"/>
                  <site-location residue="M" start="1318" end="1318"/>
                  <site-location residue="Q" start="1244" end="1244"/>
                  <site-location residue="S" start="1346" end="1346"/>
                  <site-location residue="E" start="1264" end="1264"/>
                  <site-location residue="F" start="1240" end="1240"/>
                  <site-location residue="A" start="1349" end="1349"/>
                  <site-location residue="G" start="1241" end="1241"/>
                  <site-location residue="V" start="1342" end="1342"/>
                  <site-location residue="N" start="1010" end="1010"/>
                  <site-location residue="M" start="1088" end="1088"/>
                  <site-location residue="W" start="1232" end="1232"/>
                  <site-location residue="L" start="1089" end="1089"/>
                  <site-location residue="F" start="1115" end="1115"/>
                </site-locations>
              </rpsblast-site>
            </sites>
          </rpsblast-location>
        </locations>
      </rpsblast-match>
      <superfamilyhmmer3-match evalue="1.29E-48">
        <signature ac="SSF103473" name="MFS general substrate transporter">
          <entry ac="IPR036259" desc="MFS transporter superfamily" name="MFS_trans_sf" type="HOMOLOGOUS_SUPERFAMILY">
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            <pathway-xref db="Reactome" id="R-GGA-373920" name="Pyruvate metabolism"/>
            <pathway-xref db="Reactome" id="R-RNO-425397" name="Transport of vitamins, nucleosides, and related molecules"/>
            <pathway-xref db="Reactome" id="R-MMU-181430" name="Norepinephrine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-879518" name="Transport of organic anions"/>
            <pathway-xref db="Reactome" id="R-SPO-442380" name="Zinc influx into cells by the SLC39 gene family"/>
            <pathway-xref db="Reactome" id="R-MMU-2161517" name="Abacavir transmembrane transport"/>
            <pathway-xref db="Reactome" id="R-HSA-352230" name="Amino acid transport across the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-HSA-5653890" name="Lactose synthesis"/>
            <pathway-xref db="Reactome" id="R-SCE-8981373" name="Intestinal hexose absorption"/>
            <pathway-xref db="Reactome" id="R-HSA-427975" name="Proton/oligopeptide cotransporters"/>
            <pathway-xref db="Reactome" id="R-HSA-5655799" name="Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum)"/>
            <pathway-xref db="Reactome" id="R-RNO-425410" name="Metal ion SLC transporters"/>
            <pathway-xref db="Reactome" id="R-CEL-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-HSA-196819" name="Vitamin B1 (thiamin) metabolism"/>
            <pathway-xref db="Reactome" id="R-HSA-428643" name="Organic anion transporters"/>
            <pathway-xref db="Reactome" id="R-RNO-196757" name="Metabolism of folate and pterines"/>
            <pathway-xref db="Reactome" id="R-CEL-4085001" name="Sialic acid metabolism"/>
            <pathway-xref db="Reactome" id="R-DRE-352230" name="Amino acid transport across the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-BTA-352230" name="Amino acid transport across the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-DRE-427975" name="Proton/oligopeptide cotransporters"/>
            <pathway-xref db="Reactome" id="R-RNO-189200" name="Cellular hexose transport"/>
            <pathway-xref db="Reactome" id="R-BTA-181430" name="Norepinephrine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-70268" name="Pyruvate metabolism"/>
            <pathway-xref db="Reactome" id="R-DRE-1483191" name="Synthesis of PC"/>
            <pathway-xref db="Reactome" id="R-DDI-196757" name="Metabolism of folate and pterines"/>
            <pathway-xref db="Reactome" id="R-RNO-159418" name="Recycling of bile acids and salts"/>
            <pathway-xref db="Reactome" id="R-HSA-561048" name="Organic anion transport"/>
            <pathway-xref db="Reactome" id="R-MMU-200425" name="Carnitine metabolism"/>
            <pathway-xref db="Reactome" id="R-CEL-264642" name="Acetylcholine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-SPO-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-MMU-9707616" name="Heme signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-5619049" name="Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages)"/>
            <pathway-xref db="Reactome" id="R-BTA-428643" name="Organic anion transporters"/>
            <pathway-xref db="Reactome" id="R-RNO-433692" name="Proton-coupled monocarboxylate transport"/>
            <pathway-xref db="Reactome" id="R-DRE-428643" name="Organic anion transporters"/>
            <pathway-xref db="Reactome" id="R-DME-422356" name="Regulation of insulin secretion"/>
            <pathway-xref db="Reactome" id="R-CEL-196757" name="Metabolism of folate and pterines"/>
            <pathway-xref db="MetaCyc" id="PWY-7975" name="adenosylcobalamin biosynthesis from adenosylcobinamide-GDP II"/>
            <pathway-xref db="Reactome" id="R-DRE-8856828" name="Clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-HSA-181430" name="Norepinephrine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-5619095" name="Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2)"/>
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            <pathway-xref db="Reactome" id="R-SPO-8856828" name="Clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-MMU-561048" name="Organic anion transport"/>
            <pathway-xref db="Reactome" id="R-DRE-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-DME-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-RNO-210500" name="Glutamate Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-SPO-425397" name="Transport of vitamins, nucleosides, and related molecules"/>
            <pathway-xref db="Reactome" id="R-MMU-212676" name="Dopamine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-XTR-1483191" name="Synthesis of PC"/>
            <pathway-xref db="Reactome" id="R-SPO-917937" name="Iron uptake and transport"/>
            <pathway-xref db="Reactome" id="R-SCE-429593" name="Inositol transporters"/>
            <pathway-xref db="Reactome" id="R-HSA-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-SPO-879518" name="Transport of organic anions"/>
            <pathway-xref db="Reactome" id="R-SSC-8981373" name="Intestinal hexose absorption"/>
            <pathway-xref db="Reactome" id="R-SPO-196757" name="Metabolism of folate and pterines"/>
            <pathway-xref db="MetaCyc" id="PWY-6322" name="phosphinothricin tripeptide biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-8981373" name="Intestinal hexose absorption"/>
            <pathway-xref db="Reactome" id="R-CEL-429593" name="Inositol transporters"/>
            <pathway-xref db="Reactome" id="R-MMU-5653890" name="Lactose synthesis"/>
            <pathway-xref db="Reactome" id="R-SPO-181429" name="Serotonin Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-264642" name="Acetylcholine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-BTA-442660" name="Na+/Cl- dependent neurotransmitter transporters"/>
            <pathway-xref db="Reactome" id="R-XTR-189200" name="Cellular hexose transport"/>
            <pathway-xref db="Reactome" id="R-HSA-70263" name="Gluconeogenesis"/>
            <pathway-xref db="Reactome" id="R-HSA-5662702" name="Melanin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-549127" name="Organic cation transport"/>
            <pathway-xref db="Reactome" id="R-HSA-210991" name="Basigin interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-5619110" name="Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR)"/>
            <pathway-xref db="Reactome" id="R-XTR-210500" name="Glutamate Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-422356" name="Regulation of insulin secretion"/>
            <pathway-xref db="Reactome" id="R-HSA-429593" name="Inositol transporters"/>
            <pathway-xref db="Reactome" id="R-SPO-429593" name="Inositol transporters"/>
            <pathway-xref db="Reactome" id="R-GGA-352832" name="Glucose transport"/>
            <pathway-xref db="Reactome" id="R-HSA-1660661" name="Sphingolipid de novo biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-5619061" name="Defective SLC33A1 causes spastic paraplegia 42 (SPG42)"/>
            <pathway-xref db="Reactome" id="R-DME-879518" name="Transport of organic anions"/>
            <pathway-xref db="Reactome" id="R-MMU-210500" name="Glutamate Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-210991" name="Basigin interactions"/>
            <pathway-xref db="Reactome" id="R-BTA-549127" name="Organic cation transport"/>
            <pathway-xref db="Reactome" id="R-HSA-351906" name="Apoptotic cleavage of cell adhesion proteins"/>
            <pathway-xref db="Reactome" id="R-MMU-442660" name="Na+/Cl- dependent neurotransmitter transporters"/>
            <pathway-xref db="Reactome" id="R-RNO-212676" name="Dopamine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-SCE-196836" name="Vitamin C (ascorbate) metabolism"/>
            <pathway-xref db="Reactome" id="R-CEL-197264" name="Nicotinamide salvaging"/>
            <pathway-xref db="MetaCyc" id="PWY-7740" name="beta-D-mannosyl phosphomycoketide biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-200425" name="Carnitine metabolism"/>
            <pathway-xref db="Reactome" id="R-SPO-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-RNO-429593" name="Inositol transporters"/>
            <pathway-xref db="Reactome" id="R-RNO-422356" name="Regulation of insulin secretion"/>
            <pathway-xref db="Reactome" id="R-MMU-427975" name="Proton/oligopeptide cotransporters"/>
            <pathway-xref db="Reactome" id="R-RNO-181429" name="Serotonin Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-917937" name="Iron uptake and transport"/>
            <pathway-xref db="Reactome" id="R-HSA-5619043" name="Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1)"/>
            <pathway-xref db="Reactome" id="R-HSA-5619060" name="Defective CP causes aceruloplasminemia (ACERULOP)"/>
            <pathway-xref db="Reactome" id="R-MMU-196757" name="Metabolism of folate and pterines"/>
            <pathway-xref db="Reactome" id="R-SCE-5653890" name="Lactose synthesis"/>
            <pathway-xref db="Reactome" id="R-SCE-352230" name="Amino acid transport across the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-HSA-264642" name="Acetylcholine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-8856828" name="Clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-RNO-181430" name="Norepinephrine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-DRE-425410" name="Metal ion SLC transporters"/>
            <pathway-xref db="Reactome" id="R-MMU-879518" name="Transport of organic anions"/>
            <pathway-xref db="MetaCyc" id="PWY-5129" name="sphingolipid biosynthesis (plants)"/>
            <pathway-xref db="Reactome" id="R-RNO-112311" name="Neurotransmitter clearance"/>
            <pathway-xref db="Reactome" id="R-HSA-5619053" name="Defective SLC22A5 causes systemic primary carnitine deficiency (CDSP)"/>
            <pathway-xref db="Reactome" id="R-DRE-1660661" name="Sphingolipid de novo biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-189483" name="Heme degradation"/>
            <pathway-xref db="Reactome" id="R-CEL-561048" name="Organic anion transport"/>
            <pathway-xref db="Reactome" id="R-HSA-5250955" name="Toxicity of botulinum toxin type D (botD)"/>
            <pathway-xref db="Reactome" id="R-MMU-196819" name="Vitamin B1 (thiamin) metabolism"/>
            <pathway-xref db="Reactome" id="R-RNO-9707616" name="Heme signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-1660661" name="Sphingolipid de novo biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9707616" name="Heme signaling"/>
            <pathway-xref db="Reactome" id="R-BTA-196757" name="Metabolism of folate and pterines"/>
            <pathway-xref db="MetaCyc" id="PWY-7886" name="cell-surface glycoconjugate-linked phosphocholine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SSC-561048" name="Organic anion transport"/>
            <pathway-xref db="Reactome" id="R-DME-189200" name="Cellular hexose transport"/>
            <pathway-xref db="Reactome" id="R-SPO-189200" name="Cellular hexose transport"/>
            <pathway-xref db="Reactome" id="R-HSA-2161517" name="Abacavir transmembrane transport"/>
            <pathway-xref db="Reactome" id="R-MMU-425397" name="Transport of vitamins, nucleosides, and related molecules"/>
            <pathway-xref db="Reactome" id="R-DRE-561048" name="Organic anion transport"/>
            <pathway-xref db="Reactome" id="R-SCE-189200" name="Cellular hexose transport"/>
            <pathway-xref db="Reactome" id="R-DME-8856828" name="Clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-RNO-2161517" name="Abacavir transmembrane transport"/>
            <pathway-xref db="Reactome" id="R-HSA-196836" name="Vitamin C (ascorbate) metabolism"/>
            <pathway-xref db="Reactome" id="R-HSA-189200" name="Cellular hexose transport"/>
            <pathway-xref db="Reactome" id="R-HSA-5619047" name="Defective SLC2A9 causes hypouricemia renal 2 (RHUC2)"/>
            <pathway-xref db="Reactome" id="R-HSA-196757" name="Metabolism of folate and pterines"/>
            <pathway-xref db="Reactome" id="R-SPO-9707616" name="Heme signaling"/>
            <pathway-xref db="Reactome" id="R-SPO-427975" name="Proton/oligopeptide cotransporters"/>
            <pathway-xref db="Reactome" id="R-SPO-352230" name="Amino acid transport across the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-BTA-879518" name="Transport of organic anions"/>
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            <pathway-xref db="Reactome" id="R-RNO-428643" name="Organic anion transporters"/>
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            <pathway-xref db="Reactome" id="R-RNO-975957" name="Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"/>
            <pathway-xref db="Reactome" id="R-GGA-2500257" name="Resolution of Sister Chromatid Cohesion"/>
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            <pathway-xref db="Reactome" id="R-DRE-674695" name="RNA Polymerase II Pre-transcription Events"/>
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          <signature-library-release library="SUPERFAMILY" version="1.75"/>
        </signature>
        <model-ac>0049440</model-ac>
        <locations>
          <superfamilyhmmer3-location hmm-length="393" start="237" end="610">
            <location-fragments>
              <superfamilyhmmer3-location-fragment start="566" end="610" dc-status="N_TERMINAL_DISC"/>
              <superfamilyhmmer3-location-fragment start="472" end="524" dc-status="NC_TERMINAL_DISC"/>
              <superfamilyhmmer3-location-fragment start="237" end="315" dc-status="C_TERMINAL_DISC"/>
            </location-fragments>
          </superfamilyhmmer3-location>
        </locations>
      </superfamilyhmmer3-match>
    </matches>
  </protein>
  <protein>
    <sequence md5="6592190ac4edd838ab7753454a0c0d38">MGANISQLERDIGSDQFPPNEHYFGLVNFGNTCYSNSVLQALYFCRPFREKVLEYKARNKRTKETLLTCLADLFYSIATQKKKVGSIAPKKFIARLRKEKEEFDNYMQQDAHEFLNFLINHINEIILAERTQNKPAGGKCGAGDAAGSPPEPTWVHEIFQGILTSETRCLNCETVSSKDEDFFDLQVDVDQNTSITHCLRCFSNTETLCSDNKFKCDHCSSYQEAQKRMRVKKLPMILALHLKRFKYVEQYNRHIKVSHRVVFPLELRLFNTSDDAVNPDRLYDLVAVVIHCGSGPNRGHYISIVKSHGFWLLFDDDMVDKIDASTIEDFYGLTSDIQKSSETGYILFYQSRDCS</sequence>
    <xref id="XP_029177046.1" name="XP_029177046.1 ubiquitin carboxyl-terminal hydrolase 46 [Nylanderia fulva]"/>
    <matches>
      <hmmer3-match evalue="7.2E-113" score="379.0">
        <signature ac="G3DSA:3.90.70.10" name="Cysteine proteinases">
          <signature-library-release library="GENE3D" version="4.3.0"/>
        </signature>
        <model-ac>5k16A00</model-ac>
        <locations>
          <hmmer3-location env-end="353" env-start="2" post-processed="true" score="378.7" evalue="8.9E-113" hmm-start="5" hmm-end="354" hmm-length="355" hmm-bounds="COMPLETE" start="2" end="353">
            <location-fragments>
              <hmmer3-location-fragment start="2" end="353" dc-status="CONTINUOUS"/>
            </location-fragments>
          </hmmer3-location>
        </locations>
      </hmmer3-match>
      <hmmer3-match evalue="6.9E-64" score="216.0">
        <signature ac="PF00443" desc="Ubiquitin carboxyl-terminal hydrolase" name="UCH">
          <entry ac="IPR001394" desc="Peptidase C19, ubiquitin carboxyl-terminal hydrolase" name="Peptidase_C19_UCH" type="DOMAIN">
            <go-xref category="BIOLOGICAL_PROCESS" db="GO" id="GO:0016579" name="protein deubiquitination"/>
            <go-xref category="MOLECULAR_FUNCTION" db="GO" id="GO:0004843" name="thiol-dependent deubiquitinase"/>
            <pathway-xref db="Reactome" id="R-MMU-9664873" name="Pexophagy"/>
            <pathway-xref db="Reactome" id="R-HSA-5357956" name="TNFR1-induced NFkappaB signaling pathway"/>
            <pathway-xref db="Reactome" id="R-MMU-1358803" name="Downregulation of ERBB2:ERBB3 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-5357905" name="Regulation of TNFR1 signaling"/>
            <pathway-xref db="Reactome" id="R-DDI-8948751" name="Regulation of PTEN stability and activity"/>
            <pathway-xref db="Reactome" id="R-DME-6781823" name="Formation of TC-NER Pre-Incision Complex"/>
            <pathway-xref db="Reactome" id="R-HSA-1358803" name="Downregulation of ERBB2:ERBB3 signaling"/>
            <pathway-xref db="Reactome" id="R-DME-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-SCE-8948747" name="Regulation of PTEN localization"/>
            <pathway-xref db="Reactome" id="R-XTR-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-MMU-6782135" name="Dual incision in TC-NER"/>
            <pathway-xref db="Reactome" id="R-DME-9033241" name="Peroxisomal protein import"/>
            <pathway-xref db="Reactome" id="R-DME-201681" name="TCF dependent signaling in response to WNT"/>
            <pathway-xref db="Reactome" id="R-HSA-9664873" name="Pexophagy"/>
            <pathway-xref db="Reactome" id="R-HSA-6782135" name="Dual incision in TC-NER"/>
            <pathway-xref db="Reactome" id="R-HSA-72163" name="mRNA Splicing - Major Pathway"/>
            <pathway-xref db="Reactome" id="R-MMU-1169408" name="ISG15 antiviral mechanism"/>
            <pathway-xref db="Reactome" id="R-HSA-5689603" name="UCH proteinases"/>
            <pathway-xref db="Reactome" id="R-CEL-6782135" name="Dual incision in TC-NER"/>
            <pathway-xref db="Reactome" id="R-HSA-6804757" name="Regulation of TP53 Degradation"/>
            <pathway-xref db="Reactome" id="R-CFA-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-HSA-6807004" name="Negative regulation of MET activity"/>
            <pathway-xref db="Reactome" id="R-RNO-6804757" name="Regulation of TP53 Degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-9010553" name="Regulation of expression of SLITs and ROBOs"/>
            <pathway-xref db="Reactome" id="R-HSA-977225" name="Amyloid fiber formation"/>
            <pathway-xref db="Reactome" id="R-MMU-5357956" name="TNFR1-induced NFkappaB signaling pathway"/>
            <pathway-xref db="Reactome" id="R-DRE-5696395" name="Formation of Incision Complex in GG-NER"/>
            <pathway-xref db="Reactome" id="R-SPO-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-DRE-9010553" name="Regulation of expression of SLITs and ROBOs"/>
            <pathway-xref db="Reactome" id="R-MMU-110314" name="Recognition of DNA damage by PCNA-containing replication complex"/>
            <pathway-xref db="Reactome" id="R-SCE-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-MMU-5696395" name="Formation of Incision Complex in GG-NER"/>
            <pathway-xref db="Reactome" id="R-MMU-6781823" name="Formation of TC-NER Pre-Incision Complex"/>
            <pathway-xref db="Reactome" id="R-RNO-6782210" name="Gap-filling DNA repair synthesis and ligation in TC-NER"/>
            <pathway-xref db="Reactome" id="R-MMU-5656169" name="Termination of translesion DNA synthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-936440" name="Negative regulators of DDX58/IFIH1 signaling"/>
            <pathway-xref db="Reactome" id="R-DME-6782210" name="Gap-filling DNA repair synthesis and ligation in TC-NER"/>
            <pathway-xref db="Reactome" id="R-RNO-6782135" name="Dual incision in TC-NER"/>
            <pathway-xref db="Reactome" id="R-MMU-9033241" name="Peroxisomal protein import"/>
            <pathway-xref db="Reactome" id="R-DRE-9664873" name="Pexophagy"/>
            <pathway-xref db="Reactome" id="R-DME-9013420" name="RHOU GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-2173788" name="Downregulation of TGF-beta receptor signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-5357905" name="Regulation of TNFR1 signaling"/>
            <pathway-xref db="Reactome" id="R-SPO-5696395" name="Formation of Incision Complex in GG-NER"/>
            <pathway-xref db="Reactome" id="R-DRE-8948751" name="Regulation of PTEN stability and activity"/>
            <pathway-xref db="Reactome" id="R-MMU-72163" name="mRNA Splicing - Major Pathway"/>
            <pathway-xref db="Reactome" id="R-HSA-3214847" name="HATs acetylate histones"/>
            <pathway-xref db="Reactome" id="R-HSA-201681" name="TCF dependent signaling in response to WNT"/>
            <pathway-xref db="Reactome" id="R-MMU-8866652" name="Synthesis of active ubiquitin: roles of E1 and E2 enzymes"/>
            <pathway-xref db="Reactome" id="R-BTA-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-HSA-6781823" name="Formation of TC-NER Pre-Incision Complex"/>
            <pathway-xref db="Reactome" id="R-MMU-168638" name="NOD1/2 Signaling Pathway"/>
            <pathway-xref db="Reactome" id="R-MMU-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-HSA-5357905" name="Regulation of TNFR1 signaling"/>
            <pathway-xref db="Reactome" id="R-DRE-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-DME-6804757" name="Regulation of TP53 Degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-6783310" name="Fanconi Anemia Pathway"/>
            <pathway-xref db="Reactome" id="R-SPO-6782135" name="Dual incision in TC-NER"/>
            <pathway-xref db="Reactome" id="R-CEL-6782210" name="Gap-filling DNA repair synthesis and ligation in TC-NER"/>
            <pathway-xref db="Reactome" id="R-MMU-9010553" name="Regulation of expression of SLITs and ROBOs"/>
            <pathway-xref db="Reactome" id="R-HSA-390471" name="Association of TriC/CCT with target proteins during biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-168638" name="NOD1/2 Signaling Pathway"/>
            <pathway-xref db="Reactome" id="R-SPO-6781823" name="Formation of TC-NER Pre-Incision Complex"/>
            <pathway-xref db="Reactome" id="R-RNO-110314" name="Recognition of DNA damage by PCNA-containing replication complex"/>
            <pathway-xref db="Reactome" id="R-MMU-8948747" name="Regulation of PTEN localization"/>
            <pathway-xref db="Reactome" id="R-DDI-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-HSA-936440" name="Negative regulators of DDX58/IFIH1 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-6807004" name="Negative regulation of MET activity"/>
            <pathway-xref db="Reactome" id="R-RNO-6783310" name="Fanconi Anemia Pathway"/>
            <pathway-xref db="Reactome" id="R-DDI-8866652" name="Synthesis of active ubiquitin: roles of E1 and E2 enzymes"/>
            <pathway-xref db="Reactome" id="R-MMU-8948751" name="Regulation of PTEN stability and activity"/>
            <pathway-xref db="Reactome" id="R-HSA-6782210" name="Gap-filling DNA repair synthesis and ligation in TC-NER"/>
            <pathway-xref db="Reactome" id="R-RNO-8948747" name="Regulation of PTEN localization"/>
            <pathway-xref db="Reactome" id="R-HSA-5357786" name="TNFR1-induced proapoptotic signaling"/>
            <pathway-xref db="Reactome" id="R-CEL-6781823" name="Formation of TC-NER Pre-Incision Complex"/>
            <pathway-xref db="Reactome" id="R-HSA-8948751" name="Regulation of PTEN stability and activity"/>
            <pathway-xref db="Reactome" id="R-MMU-6782210" name="Gap-filling DNA repair synthesis and ligation in TC-NER"/>
            <pathway-xref db="Reactome" id="R-HSA-4641263" name="Regulation of FZD by ubiquitination"/>
            <pathway-xref db="Reactome" id="R-MMU-6783310" name="Fanconi Anemia Pathway"/>
            <pathway-xref db="Reactome" id="R-MMU-2173795" name="Downregulation of SMAD2/3:SMAD4 transcriptional activity"/>
            <pathway-xref db="Reactome" id="R-MMU-912694" name="Regulation of IFNA signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-6781823" name="Formation of TC-NER Pre-Incision Complex"/>
            <pathway-xref db="Reactome" id="R-DME-8866652" name="Synthesis of active ubiquitin: roles of E1 and E2 enzymes"/>
            <pathway-xref db="Reactome" id="R-RNO-168638" name="NOD1/2 Signaling Pathway"/>
            <pathway-xref db="Reactome" id="R-CEL-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-SCE-5656169" name="Termination of translesion DNA synthesis"/>
            <pathway-xref db="Reactome" id="R-SPO-6782210" name="Gap-filling DNA repair synthesis and ligation in TC-NER"/>
            <pathway-xref db="Reactome" id="R-DME-9013424" name="RHOV GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-9013424" name="RHOV GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DME-9648002" name="RAS processing"/>
            <pathway-xref db="Reactome" id="R-MMU-201681" name="TCF dependent signaling in response to WNT"/>
            <pathway-xref db="Reactome" id="R-SCE-6782210" name="Gap-filling DNA repair synthesis and ligation in TC-NER"/>
            <pathway-xref db="Reactome" id="R-SPO-5656169" name="Termination of translesion DNA synthesis"/>
            <pathway-xref db="Reactome" id="R-SPO-8866652" name="Synthesis of active ubiquitin: roles of E1 and E2 enzymes"/>
            <pathway-xref db="Reactome" id="R-HSA-9013420" name="RHOU GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-5696395" name="Formation of Incision Complex in GG-NER"/>
            <pathway-xref db="Reactome" id="R-SCE-8866652" name="Synthesis of active ubiquitin: roles of E1 and E2 enzymes"/>
            <pathway-xref db="Reactome" id="R-MMU-5357786" name="TNFR1-induced proapoptotic signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-9664873" name="Pexophagy"/>
            <pathway-xref db="Reactome" id="R-HSA-8948747" name="Regulation of PTEN localization"/>
            <pathway-xref db="Reactome" id="R-HSA-110314" name="Recognition of DNA damage by PCNA-containing replication complex"/>
            <pathway-xref db="Reactome" id="R-RNO-5357956" name="TNFR1-induced NFkappaB signaling pathway"/>
            <pathway-xref db="Reactome" id="R-RNO-5357786" name="TNFR1-induced proapoptotic signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-5656169" name="Termination of translesion DNA synthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-8866652" name="Synthesis of active ubiquitin: roles of E1 and E2 enzymes"/>
            <pathway-xref db="Reactome" id="R-DME-6782135" name="Dual incision in TC-NER"/>
            <pathway-xref db="Reactome" id="R-HSA-9648002" name="RAS processing"/>
            <pathway-xref db="Reactome" id="R-HSA-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-DME-2173795" name="Downregulation of SMAD2/3:SMAD4 transcriptional activity"/>
            <pathway-xref db="Reactome" id="R-HSA-9033241" name="Peroxisomal protein import"/>
            <pathway-xref db="Reactome" id="R-SPO-110314" name="Recognition of DNA damage by PCNA-containing replication complex"/>
            <pathway-xref db="Reactome" id="R-MMU-9648002" name="RAS processing"/>
            <pathway-xref db="Reactome" id="R-CEL-8866652" name="Synthesis of active ubiquitin: roles of E1 and E2 enzymes"/>
            <pathway-xref db="Reactome" id="R-SCE-6781823" name="Formation of TC-NER Pre-Incision Complex"/>
            <pathway-xref db="Reactome" id="R-CEL-8948747" name="Regulation of PTEN localization"/>
            <pathway-xref db="Reactome" id="R-HSA-2173795" name="Downregulation of SMAD2/3:SMAD4 transcriptional activity"/>
            <pathway-xref db="Reactome" id="R-HSA-912694" name="Regulation of IFNA signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-1169408" name="ISG15 antiviral mechanism"/>
            <pathway-xref db="Reactome" id="R-RNO-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-HSA-9013424" name="RHOV GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-4641263" name="Regulation of FZD by ubiquitination"/>
            <pathway-xref db="Reactome" id="R-MMU-9013420" name="RHOU GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-8866652" name="Synthesis of active ubiquitin: roles of E1 and E2 enzymes"/>
            <pathway-xref db="Reactome" id="R-SPO-9648002" name="RAS processing"/>
            <pathway-xref db="Reactome" id="R-HSA-6781827" name="Transcription-Coupled Nucleotide Excision Repair (TC-NER)"/>
            <pathway-xref db="Reactome" id="R-SCE-6782135" name="Dual incision in TC-NER"/>
            <pathway-xref db="Reactome" id="R-RNO-5656169" name="Termination of translesion DNA synthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-6804757" name="Regulation of TP53 Degradation"/>
            <pathway-xref db="Reactome" id="R-DME-8948747" name="Regulation of PTEN localization"/>
          </entry>
          <signature-library-release library="PFAM" version="34.0"/>
        </signature>
        <model-ac>PF00443</model-ac>
        <locations>
          <hmmer3-location env-end="349" env-start="24" post-processed="true" score="215.8" evalue="8.0E-64" hmm-start="1" hmm-end="278" hmm-length="278" hmm-bounds="COMPLETE" start="24" end="349">
            <location-fragments>
              <hmmer3-location-fragment start="24" end="349" dc-status="CONTINUOUS"/>
            </location-fragments>
          </hmmer3-location>
        </locations>
      </hmmer3-match>
      <panther-match evalue="1.9E-169" familyName="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 46" score="574.9">
        <signature ac="PTHR24006" name="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE">
          <signature-library-release library="PANTHER" version="15.0"/>
        </signature>
        <model-ac>PTHR24006</model-ac>
        <locations>
          <panther-location env-start="1" env-end="353" hmm-start="13" hmm-end="367" hmm-length="367" hmm-bounds="COMPLETE" start="1" end="353">
            <location-fragments>
              <panther-location-fragment start="1" end="353" dc-status="CONTINUOUS"/>
            </location-fragments>
          </panther-location>
        </locations>
      </panther-match>
      <panther-match evalue="1.9E-169" familyName="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 46" score="574.9">
        <signature ac="PTHR24006:SF714" name="UBIQUITIN CARBOXYL-TERMINAL HYDROLASE 46">
          <signature-library-release library="PANTHER" version="15.0"/>
        </signature>
        <model-ac>PTHR24006:SF714</model-ac>
        <locations>
          <panther-location env-start="1" env-end="353" hmm-start="13" hmm-end="367" hmm-length="367" hmm-bounds="COMPLETE" start="1" end="353">
            <location-fragments>
              <panther-location-fragment start="1" end="353" dc-status="CONTINUOUS"/>
            </location-fragments>
          </panther-location>
        </locations>
      </panther-match>
      <patternscan-match>
        <signature ac="PS00973" desc="Ubiquitin specific protease (USP) domain signature 2." name="USP_2">
          <entry ac="IPR018200" desc="Ubiquitin specific protease, conserved site" name="USP_CS" type="CONSERVED_SITE">
            <go-xref category="MOLECULAR_FUNCTION" db="GO" id="GO:0004843" name="thiol-dependent deubiquitinase"/>
            <go-xref category="BIOLOGICAL_PROCESS" db="GO" id="GO:0006511" name="ubiquitin-dependent protein catabolic process"/>
            <pathway-xref db="Reactome" id="R-MMU-9664873" name="Pexophagy"/>
            <pathway-xref db="Reactome" id="R-HSA-5357956" name="TNFR1-induced NFkappaB signaling pathway"/>
            <pathway-xref db="Reactome" id="R-MMU-1358803" name="Downregulation of ERBB2:ERBB3 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-5357905" name="Regulation of TNFR1 signaling"/>
            <pathway-xref db="Reactome" id="R-DDI-8948751" name="Regulation of PTEN stability and activity"/>
            <pathway-xref db="Reactome" id="R-DME-6781823" name="Formation of TC-NER Pre-Incision Complex"/>
            <pathway-xref db="Reactome" id="R-HSA-1358803" name="Downregulation of ERBB2:ERBB3 signaling"/>
            <pathway-xref db="Reactome" id="R-DME-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-SCE-8948747" name="Regulation of PTEN localization"/>
            <pathway-xref db="Reactome" id="R-XTR-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-MMU-6782135" name="Dual incision in TC-NER"/>
            <pathway-xref db="Reactome" id="R-DME-9033241" name="Peroxisomal protein import"/>
            <pathway-xref db="Reactome" id="R-DME-201681" name="TCF dependent signaling in response to WNT"/>
            <pathway-xref db="Reactome" id="R-HSA-9664873" name="Pexophagy"/>
            <pathway-xref db="Reactome" id="R-HSA-6782135" name="Dual incision in TC-NER"/>
            <pathway-xref db="Reactome" id="R-MMU-1169408" name="ISG15 antiviral mechanism"/>
            <pathway-xref db="Reactome" id="R-HSA-5689603" name="UCH proteinases"/>
            <pathway-xref db="Reactome" id="R-CEL-6782135" name="Dual incision in TC-NER"/>
            <pathway-xref db="Reactome" id="R-HSA-6804757" name="Regulation of TP53 Degradation"/>
            <pathway-xref db="Reactome" id="R-CFA-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-HSA-6807004" name="Negative regulation of MET activity"/>
            <pathway-xref db="Reactome" id="R-RNO-6804757" name="Regulation of TP53 Degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-9010553" name="Regulation of expression of SLITs and ROBOs"/>
            <pathway-xref db="Reactome" id="R-HSA-977225" name="Amyloid fiber formation"/>
            <pathway-xref db="Reactome" id="R-MMU-5357956" name="TNFR1-induced NFkappaB signaling pathway"/>
            <pathway-xref db="Reactome" id="R-DRE-5696395" name="Formation of Incision Complex in GG-NER"/>
            <pathway-xref db="Reactome" id="R-SPO-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-DRE-9010553" name="Regulation of expression of SLITs and ROBOs"/>
            <pathway-xref db="Reactome" id="R-MMU-110314" name="Recognition of DNA damage by PCNA-containing replication complex"/>
            <pathway-xref db="Reactome" id="R-SCE-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-MMU-5696395" name="Formation of Incision Complex in GG-NER"/>
            <pathway-xref db="Reactome" id="R-MMU-6781823" name="Formation of TC-NER Pre-Incision Complex"/>
            <pathway-xref db="Reactome" id="R-RNO-6782210" name="Gap-filling DNA repair synthesis and ligation in TC-NER"/>
            <pathway-xref db="Reactome" id="R-MMU-5656169" name="Termination of translesion DNA synthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-936440" name="Negative regulators of DDX58/IFIH1 signaling"/>
            <pathway-xref db="Reactome" id="R-DME-6782210" name="Gap-filling DNA repair synthesis and ligation in TC-NER"/>
            <pathway-xref db="Reactome" id="R-RNO-6782135" name="Dual incision in TC-NER"/>
            <pathway-xref db="Reactome" id="R-MMU-9033241" name="Peroxisomal protein import"/>
            <pathway-xref db="Reactome" id="R-DRE-9664873" name="Pexophagy"/>
            <pathway-xref db="Reactome" id="R-DME-9013420" name="RHOU GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-2173788" name="Downregulation of TGF-beta receptor signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-5357905" name="Regulation of TNFR1 signaling"/>
            <pathway-xref db="Reactome" id="R-SPO-5696395" name="Formation of Incision Complex in GG-NER"/>
            <pathway-xref db="Reactome" id="R-DRE-8948751" name="Regulation of PTEN stability and activity"/>
            <pathway-xref db="Reactome" id="R-HSA-3214847" name="HATs acetylate histones"/>
            <pathway-xref db="Reactome" id="R-HSA-201681" name="TCF dependent signaling in response to WNT"/>
            <pathway-xref db="Reactome" id="R-MMU-8866652" name="Synthesis of active ubiquitin: roles of E1 and E2 enzymes"/>
            <pathway-xref db="Reactome" id="R-BTA-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-HSA-6781823" name="Formation of TC-NER Pre-Incision Complex"/>
            <pathway-xref db="Reactome" id="R-MMU-168638" name="NOD1/2 Signaling Pathway"/>
            <pathway-xref db="Reactome" id="R-MMU-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-HSA-5357905" name="Regulation of TNFR1 signaling"/>
            <pathway-xref db="Reactome" id="R-DRE-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-DME-6804757" name="Regulation of TP53 Degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-6783310" name="Fanconi Anemia Pathway"/>
            <pathway-xref db="Reactome" id="R-SPO-6782135" name="Dual incision in TC-NER"/>
            <pathway-xref db="Reactome" id="R-CEL-6782210" name="Gap-filling DNA repair synthesis and ligation in TC-NER"/>
            <pathway-xref db="Reactome" id="R-MMU-9010553" name="Regulation of expression of SLITs and ROBOs"/>
            <pathway-xref db="Reactome" id="R-HSA-390471" name="Association of TriC/CCT with target proteins during biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-168638" name="NOD1/2 Signaling Pathway"/>
            <pathway-xref db="Reactome" id="R-SPO-6781823" name="Formation of TC-NER Pre-Incision Complex"/>
            <pathway-xref db="Reactome" id="R-RNO-110314" name="Recognition of DNA damage by PCNA-containing replication complex"/>
            <pathway-xref db="Reactome" id="R-MMU-8948747" name="Regulation of PTEN localization"/>
            <pathway-xref db="Reactome" id="R-DDI-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-HSA-936440" name="Negative regulators of DDX58/IFIH1 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-6807004" name="Negative regulation of MET activity"/>
            <pathway-xref db="Reactome" id="R-RNO-6783310" name="Fanconi Anemia Pathway"/>
            <pathway-xref db="Reactome" id="R-DDI-8866652" name="Synthesis of active ubiquitin: roles of E1 and E2 enzymes"/>
            <pathway-xref db="Reactome" id="R-MMU-8948751" name="Regulation of PTEN stability and activity"/>
            <pathway-xref db="Reactome" id="R-HSA-6782210" name="Gap-filling DNA repair synthesis and ligation in TC-NER"/>
            <pathway-xref db="Reactome" id="R-RNO-8948747" name="Regulation of PTEN localization"/>
            <pathway-xref db="Reactome" id="R-HSA-5357786" name="TNFR1-induced proapoptotic signaling"/>
            <pathway-xref db="Reactome" id="R-CEL-6781823" name="Formation of TC-NER Pre-Incision Complex"/>
            <pathway-xref db="Reactome" id="R-HSA-8948751" name="Regulation of PTEN stability and activity"/>
            <pathway-xref db="Reactome" id="R-MMU-6782210" name="Gap-filling DNA repair synthesis and ligation in TC-NER"/>
            <pathway-xref db="Reactome" id="R-HSA-4641263" name="Regulation of FZD by ubiquitination"/>
            <pathway-xref db="Reactome" id="R-MMU-6783310" name="Fanconi Anemia Pathway"/>
            <pathway-xref db="Reactome" id="R-MMU-2173795" name="Downregulation of SMAD2/3:SMAD4 transcriptional activity"/>
            <pathway-xref db="Reactome" id="R-MMU-912694" name="Regulation of IFNA signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-6781823" name="Formation of TC-NER Pre-Incision Complex"/>
            <pathway-xref db="Reactome" id="R-DME-8866652" name="Synthesis of active ubiquitin: roles of E1 and E2 enzymes"/>
            <pathway-xref db="Reactome" id="R-RNO-168638" name="NOD1/2 Signaling Pathway"/>
            <pathway-xref db="Reactome" id="R-CEL-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-SCE-5656169" name="Termination of translesion DNA synthesis"/>
            <pathway-xref db="Reactome" id="R-SPO-6782210" name="Gap-filling DNA repair synthesis and ligation in TC-NER"/>
            <pathway-xref db="Reactome" id="R-DME-9013424" name="RHOV GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-9013424" name="RHOV GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DME-9648002" name="RAS processing"/>
            <pathway-xref db="Reactome" id="R-MMU-201681" name="TCF dependent signaling in response to WNT"/>
            <pathway-xref db="Reactome" id="R-SCE-6782210" name="Gap-filling DNA repair synthesis and ligation in TC-NER"/>
            <pathway-xref db="Reactome" id="R-SPO-5656169" name="Termination of translesion DNA synthesis"/>
            <pathway-xref db="Reactome" id="R-SPO-8866652" name="Synthesis of active ubiquitin: roles of E1 and E2 enzymes"/>
            <pathway-xref db="Reactome" id="R-HSA-9013420" name="RHOU GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-5696395" name="Formation of Incision Complex in GG-NER"/>
            <pathway-xref db="Reactome" id="R-SCE-8866652" name="Synthesis of active ubiquitin: roles of E1 and E2 enzymes"/>
            <pathway-xref db="Reactome" id="R-MMU-5357786" name="TNFR1-induced proapoptotic signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-9664873" name="Pexophagy"/>
            <pathway-xref db="Reactome" id="R-HSA-8948747" name="Regulation of PTEN localization"/>
            <pathway-xref db="Reactome" id="R-HSA-110314" name="Recognition of DNA damage by PCNA-containing replication complex"/>
            <pathway-xref db="Reactome" id="R-RNO-5357956" name="TNFR1-induced NFkappaB signaling pathway"/>
            <pathway-xref db="Reactome" id="R-RNO-5357786" name="TNFR1-induced proapoptotic signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-5656169" name="Termination of translesion DNA synthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-8866652" name="Synthesis of active ubiquitin: roles of E1 and E2 enzymes"/>
            <pathway-xref db="Reactome" id="R-DME-6782135" name="Dual incision in TC-NER"/>
            <pathway-xref db="Reactome" id="R-HSA-9648002" name="RAS processing"/>
            <pathway-xref db="Reactome" id="R-HSA-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-DME-2173795" name="Downregulation of SMAD2/3:SMAD4 transcriptional activity"/>
            <pathway-xref db="Reactome" id="R-HSA-9033241" name="Peroxisomal protein import"/>
            <pathway-xref db="Reactome" id="R-SPO-110314" name="Recognition of DNA damage by PCNA-containing replication complex"/>
            <pathway-xref db="Reactome" id="R-MMU-9648002" name="RAS processing"/>
            <pathway-xref db="Reactome" id="R-CEL-8866652" name="Synthesis of active ubiquitin: roles of E1 and E2 enzymes"/>
            <pathway-xref db="Reactome" id="R-SCE-6781823" name="Formation of TC-NER Pre-Incision Complex"/>
            <pathway-xref db="Reactome" id="R-CEL-8948747" name="Regulation of PTEN localization"/>
            <pathway-xref db="Reactome" id="R-HSA-2173795" name="Downregulation of SMAD2/3:SMAD4 transcriptional activity"/>
            <pathway-xref db="Reactome" id="R-HSA-912694" name="Regulation of IFNA signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-1169408" name="ISG15 antiviral mechanism"/>
            <pathway-xref db="Reactome" id="R-RNO-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-HSA-9013424" name="RHOV GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-4641263" name="Regulation of FZD by ubiquitination"/>
            <pathway-xref db="Reactome" id="R-MMU-9013420" name="RHOU GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-8866652" name="Synthesis of active ubiquitin: roles of E1 and E2 enzymes"/>
            <pathway-xref db="Reactome" id="R-SPO-9648002" name="RAS processing"/>
            <pathway-xref db="Reactome" id="R-HSA-6781827" name="Transcription-Coupled Nucleotide Excision Repair (TC-NER)"/>
            <pathway-xref db="Reactome" id="R-SCE-6782135" name="Dual incision in TC-NER"/>
            <pathway-xref db="Reactome" id="R-RNO-5656169" name="Termination of translesion DNA synthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-6804757" name="Regulation of TP53 Degradation"/>
            <pathway-xref db="Reactome" id="R-DME-8948747" name="Regulation of PTEN localization"/>
          </entry>
          <signature-library-release library="PROSITE_PATTERNS" version="2021_01"/>
        </signature>
        <model-ac>PS00973</model-ac>
        <locations>
          <patternscan-location level="STRONG" start="283" end="301">
            <location-fragments>
              <patternscan-location-fragment start="283" end="301" dc-status="CONTINUOUS"/>
            </location-fragments>
            <alignment>YdLvAVviHcGsgpnrGHY</alignment>
          </patternscan-location>
        </locations>
      </patternscan-match>
      <profilescan-match>
        <signature ac="PS50235" desc="Ubiquitin specific protease (USP) domain profile." name="USP_3">
          <entry ac="IPR028889" desc="Ubiquitin specific protease domain" name="USP_dom" type="DOMAIN">
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            <pathway-xref db="Reactome" id="R-HSA-5357956" name="TNFR1-induced NFkappaB signaling pathway"/>
            <pathway-xref db="Reactome" id="R-MMU-1358803" name="Downregulation of ERBB2:ERBB3 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-5357905" name="Regulation of TNFR1 signaling"/>
            <pathway-xref db="Reactome" id="R-DDI-8948751" name="Regulation of PTEN stability and activity"/>
            <pathway-xref db="Reactome" id="R-DME-6781823" name="Formation of TC-NER Pre-Incision Complex"/>
            <pathway-xref db="Reactome" id="R-HSA-1358803" name="Downregulation of ERBB2:ERBB3 signaling"/>
            <pathway-xref db="Reactome" id="R-DME-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-SCE-8948747" name="Regulation of PTEN localization"/>
            <pathway-xref db="Reactome" id="R-XTR-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-MMU-6782135" name="Dual incision in TC-NER"/>
            <pathway-xref db="Reactome" id="R-DME-9033241" name="Peroxisomal protein import"/>
            <pathway-xref db="Reactome" id="R-DME-201681" name="TCF dependent signaling in response to WNT"/>
            <pathway-xref db="Reactome" id="R-HSA-9664873" name="Pexophagy"/>
            <pathway-xref db="Reactome" id="R-HSA-6782135" name="Dual incision in TC-NER"/>
            <pathway-xref db="Reactome" id="R-HSA-72163" name="mRNA Splicing - Major Pathway"/>
            <pathway-xref db="Reactome" id="R-MMU-1169408" name="ISG15 antiviral mechanism"/>
            <pathway-xref db="Reactome" id="R-HSA-5689603" name="UCH proteinases"/>
            <pathway-xref db="Reactome" id="R-CEL-6782135" name="Dual incision in TC-NER"/>
            <pathway-xref db="Reactome" id="R-HSA-6804757" name="Regulation of TP53 Degradation"/>
            <pathway-xref db="Reactome" id="R-CFA-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-HSA-6807004" name="Negative regulation of MET activity"/>
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            <pathway-xref db="Reactome" id="R-HSA-977225" name="Amyloid fiber formation"/>
            <pathway-xref db="Reactome" id="R-MMU-5357956" name="TNFR1-induced NFkappaB signaling pathway"/>
            <pathway-xref db="Reactome" id="R-DRE-5696395" name="Formation of Incision Complex in GG-NER"/>
            <pathway-xref db="Reactome" id="R-DME-429947" name="Deadenylation of mRNA"/>
            <pathway-xref db="Reactome" id="R-SPO-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-DRE-9010553" name="Regulation of expression of SLITs and ROBOs"/>
            <pathway-xref db="Reactome" id="R-MMU-110314" name="Recognition of DNA damage by PCNA-containing replication complex"/>
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            <pathway-xref db="Reactome" id="R-MMU-5696395" name="Formation of Incision Complex in GG-NER"/>
            <pathway-xref db="Reactome" id="R-GGA-429947" name="Deadenylation of mRNA"/>
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            <pathway-xref db="Reactome" id="R-RNO-6782210" name="Gap-filling DNA repair synthesis and ligation in TC-NER"/>
            <pathway-xref db="Reactome" id="R-MMU-5656169" name="Termination of translesion DNA synthesis"/>
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            <pathway-xref db="Reactome" id="R-DME-6782210" name="Gap-filling DNA repair synthesis and ligation in TC-NER"/>
            <pathway-xref db="Reactome" id="R-RNO-6782135" name="Dual incision in TC-NER"/>
            <pathway-xref db="Reactome" id="R-MMU-9033241" name="Peroxisomal protein import"/>
            <pathway-xref db="Reactome" id="R-DRE-9664873" name="Pexophagy"/>
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            <pathway-xref db="Reactome" id="R-MMU-72163" name="mRNA Splicing - Major Pathway"/>
            <pathway-xref db="Reactome" id="R-HSA-3214847" name="HATs acetylate histones"/>
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            <pathway-xref db="Reactome" id="R-MMU-168638" name="NOD1/2 Signaling Pathway"/>
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            <pathway-xref db="Reactome" id="R-HSA-5357905" name="Regulation of TNFR1 signaling"/>
            <pathway-xref db="Reactome" id="R-DRE-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-DME-6804757" name="Regulation of TP53 Degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-6783310" name="Fanconi Anemia Pathway"/>
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            <pathway-xref db="Reactome" id="R-DDI-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-HSA-936440" name="Negative regulators of DDX58/IFIH1 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-6807004" name="Negative regulation of MET activity"/>
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            <pathway-xref db="Reactome" id="R-MMU-8948751" name="Regulation of PTEN stability and activity"/>
            <pathway-xref db="Reactome" id="R-RNO-429947" name="Deadenylation of mRNA"/>
            <pathway-xref db="Reactome" id="R-HSA-6782210" name="Gap-filling DNA repair synthesis and ligation in TC-NER"/>
            <pathway-xref db="Reactome" id="R-RNO-8948747" name="Regulation of PTEN localization"/>
            <pathway-xref db="Reactome" id="R-HSA-5357786" name="TNFR1-induced proapoptotic signaling"/>
            <pathway-xref db="Reactome" id="R-CEL-6781823" name="Formation of TC-NER Pre-Incision Complex"/>
            <pathway-xref db="Reactome" id="R-HSA-8948751" name="Regulation of PTEN stability and activity"/>
            <pathway-xref db="Reactome" id="R-MMU-6782210" name="Gap-filling DNA repair synthesis and ligation in TC-NER"/>
            <pathway-xref db="Reactome" id="R-HSA-4641263" name="Regulation of FZD by ubiquitination"/>
            <pathway-xref db="Reactome" id="R-MMU-6783310" name="Fanconi Anemia Pathway"/>
            <pathway-xref db="Reactome" id="R-MMU-2173795" name="Downregulation of SMAD2/3:SMAD4 transcriptional activity"/>
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            <pathway-xref db="Reactome" id="R-RNO-6781823" name="Formation of TC-NER Pre-Incision Complex"/>
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            <pathway-xref db="Reactome" id="R-SPO-6782210" name="Gap-filling DNA repair synthesis and ligation in TC-NER"/>
            <pathway-xref db="Reactome" id="R-DME-9013424" name="RHOV GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-9013424" name="RHOV GTPase cycle"/>
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            <pathway-xref db="Reactome" id="R-SCE-6782210" name="Gap-filling DNA repair synthesis and ligation in TC-NER"/>
            <pathway-xref db="Reactome" id="R-SPO-5656169" name="Termination of translesion DNA synthesis"/>
            <pathway-xref db="Reactome" id="R-SPO-8866652" name="Synthesis of active ubiquitin: roles of E1 and E2 enzymes"/>
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            <pathway-xref db="Reactome" id="R-MMU-429947" name="Deadenylation of mRNA"/>
            <pathway-xref db="Reactome" id="R-HSA-5696395" name="Formation of Incision Complex in GG-NER"/>
            <pathway-xref db="Reactome" id="R-SCE-8866652" name="Synthesis of active ubiquitin: roles of E1 and E2 enzymes"/>
            <pathway-xref db="Reactome" id="R-MMU-5357786" name="TNFR1-induced proapoptotic signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-9664873" name="Pexophagy"/>
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            <pathway-xref db="Reactome" id="R-RNO-5357956" name="TNFR1-induced NFkappaB signaling pathway"/>
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            <pathway-xref db="Reactome" id="R-DME-6782135" name="Dual incision in TC-NER"/>
            <pathway-xref db="Reactome" id="R-HSA-9648002" name="RAS processing"/>
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            <pathway-xref db="Reactome" id="R-MMU-9648002" name="RAS processing"/>
            <pathway-xref db="Reactome" id="R-CEL-8866652" name="Synthesis of active ubiquitin: roles of E1 and E2 enzymes"/>
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            <pathway-xref db="Reactome" id="R-CEL-8948747" name="Regulation of PTEN localization"/>
            <pathway-xref db="Reactome" id="R-HSA-2173795" name="Downregulation of SMAD2/3:SMAD4 transcriptional activity"/>
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            <pathway-xref db="Reactome" id="R-RNO-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-HSA-9013424" name="RHOV GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-4641263" name="Regulation of FZD by ubiquitination"/>
            <pathway-xref db="Reactome" id="R-MMU-9013420" name="RHOU GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-8866652" name="Synthesis of active ubiquitin: roles of E1 and E2 enzymes"/>
            <pathway-xref db="Reactome" id="R-SPO-9648002" name="RAS processing"/>
            <pathway-xref db="Reactome" id="R-HSA-6781827" name="Transcription-Coupled Nucleotide Excision Repair (TC-NER)"/>
            <pathway-xref db="Reactome" id="R-SCE-6782135" name="Dual incision in TC-NER"/>
            <pathway-xref db="Reactome" id="R-RNO-5656169" name="Termination of translesion DNA synthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-6804757" name="Regulation of TP53 Degradation"/>
            <pathway-xref db="Reactome" id="R-DME-8948747" name="Regulation of PTEN localization"/>
          </entry>
          <signature-library-release library="PROSITE_PROFILES" version="2021_01"/>
        </signature>
        <model-ac>PS50235</model-ac>
        <locations>
          <profilescan-location score="63.006214" start="24" end="352">
            <location-fragments>
              <profilescan-location-fragment start="24" end="352" dc-status="CONTINUOUS"/>
            </location-fragments>
            <alignment>FGLVNFGNTCYSNSVLQALYFCRPFREKVLeYKARNKRTKETLLTCLADLFYSIAtqKKKVGSIAPKKFIARLRKEKEEFDNYMQQDAHEFLNFLINHINEII---LAERTQNKPAGGKCGAGDAAGSPPEPTWVHEIFQGILTSETRCLNCETVSSKDEDFFDLQVDVDQN---------TSITHCLRCFSNTETLCSDNKFKCDHCSSYQEAQKRMRVKKLPMILALHLKRFKYVeqYNRHIKVSHRVVFP--LELRLFNTS---DDAVNPDRLYDLVAVVIHCGSgPNRGHYISIVKSH--GFWLLFDDDMVDKIDAStiedfygltsdiQKSSETGYILFYQSR</alignment>
          </profilescan-location>
        </locations>
      </profilescan-match>
      <rpsblast-match>
        <signature ac="cd02663" desc="Peptidase_C19G" name="Peptidase_C19G">
          <signature-library-release library="CDD" version="3.18"/>
        </signature>
        <model-ac>cd02663</model-ac>
        <locations>
          <rpsblast-location evalue="0.0" score="529.959" start="25" end="350">
            <location-fragments>
              <rpsblast-location-fragment start="25" end="350" dc-status="CONTINUOUS"/>
            </location-fragments>
            <sites>
              <rpsblast-site description="Active Site" numLocations="4">
                <site-locations>
                  <site-location residue="H" start="300" end="300"/>
                  <site-location residue="D" start="316" end="316"/>
                  <site-location residue="C" start="33" end="33"/>
                  <site-location residue="N" start="28" end="28"/>
                </site-locations>
              </rpsblast-site>
            </sites>
          </rpsblast-location>
        </locations>
      </rpsblast-match>
      <superfamilyhmmer3-match evalue="2.55E-93">
        <signature ac="SSF54001" name="Cysteine proteinases">
          <entry ac="IPR038765" desc="Papain-like cysteine peptidase superfamily" name="Papain-like_cys_pep_sf" type="HOMOLOGOUS_SUPERFAMILY">
            <pathway-xref db="MetaCyc" id="PWY-8238" name="24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)"/>
            <pathway-xref db="Reactome" id="R-MMU-1474228" name="Degradation of the extracellular matrix"/>
            <pathway-xref db="Reactome" id="R-SCE-5689896" name="Ovarian tumor domain proteases"/>
            <pathway-xref db="MetaCyc" id="PWY-7735" name="echinomycin and triostin A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9610379" name="HCMV Late Events"/>
            <pathway-xref db="MetaCyc" id="PWY-7154" name="ergosterol biosynthesis II"/>
            <pathway-xref db="MetaCyc" id="PWY-7325" name="salvigenin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-2565942" name="Regulation of PLK1 Activity at G2/M Transition"/>
            <pathway-xref db="MetaCyc" id="PWY-7382" name="lipoate biosynthesis and incorporation IV (yeast)"/>
            <pathway-xref db="Reactome" id="R-DME-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-HSA-6791226" name="Major pathway of rRNA processing in the nucleolus and cytosol"/>
            <pathway-xref db="MetaCyc" id="PWY-8035" name="streptovaricin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-6782135" name="Dual incision in TC-NER"/>
            <pathway-xref db="Reactome" id="R-MMU-5620912" name="Anchoring of the basal body to the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-MMU-2565942" name="Regulation of PLK1 Activity at G2/M Transition"/>
            <pathway-xref db="MetaCyc" id="PWY-7629" name="yatein biosynthesis II"/>
            <pathway-xref db="MetaCyc" id="PWY-7621" name="autoinducer CAI-1 biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7583" name="arachidonate biosynthesis II (bacteria)"/>
            <pathway-xref db="MetaCyc" id="PWY-6973" name="dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7049" name="icosapentaenoate biosynthesis II (6-desaturase, mammals)"/>
            <pathway-xref db="Reactome" id="R-DDI-8951664" name="Neddylation"/>
            <pathway-xref db="Reactome" id="R-HSA-1474228" name="Degradation of the extracellular matrix"/>
            <pathway-xref db="Reactome" id="R-HSA-5620912" name="Anchoring of the basal body to the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-HSA-6782135" name="Dual incision in TC-NER"/>
            <pathway-xref db="MetaCyc" id="PWY-5994" name="palmitate biosynthesis I (type I fatty acid synthase)"/>
            <pathway-xref db="Reactome" id="R-MMU-6791226" name="Major pathway of rRNA processing in the nucleolus and cytosol"/>
            <pathway-xref db="Reactome" id="R-RNO-2022377" name="Metabolism of Angiotensinogen to Angiotensins"/>
            <pathway-xref db="MetaCyc" id="PWY-6978" name="plastoquinol-9 biosynthesis II"/>
            <pathway-xref db="MetaCyc" id="PWY-7460" name="2-O-acetyl-3-O-trans-coutarate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-8100" name="crotonosine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-6807004" name="Negative regulation of MET activity"/>
            <pathway-xref db="Reactome" id="R-RNO-6804757" name="Regulation of TP53 Degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-9010553" name="Regulation of expression of SLITs and ROBOs"/>
            <pathway-xref db="MetaCyc" id="PWY-8047" name="bryostatin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7711" name="calonectrin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7631" name="arctigenin and isoarctigenin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SPO-5689896" name="Ovarian tumor domain proteases"/>
            <pathway-xref db="Reactome" id="R-DME-8939242" name="RUNX1 regulates transcription of genes involved in differentiation of keratinocytes"/>
            <pathway-xref db="MetaCyc" id="PWY-6948" name="sitosterol degradation to androstenedione"/>
            <pathway-xref db="MetaCyc" id="PWY-8051" name="anandamide biosynthesis I"/>
            <pathway-xref db="Reactome" id="R-HSA-1236977" name="Endosomal/Vacuolar pathway"/>
            <pathway-xref db="MetaCyc" id="PWY-7100" name="spinosyn A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-110314" name="Recognition of DNA damage by PCNA-containing replication complex"/>
            <pathway-xref db="Reactome" id="R-DRE-380284" name="Loss of proteins required for interphase microtubule organization from the centrosome"/>
            <pathway-xref db="MetaCyc" id="PWY-7901" name="glucosinolate biosynthesis from tyrosine"/>
            <pathway-xref db="MetaCyc" id="PWY-7352" name="daunorubicin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6074" name="zymosterol biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7163" name="polymethylated kaempferol biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SPO-5689603" name="UCH proteinases"/>
            <pathway-xref db="Reactome" id="R-MMU-936440" name="Negative regulators of DDX58/IFIH1 signaling"/>
            <pathway-xref db="Reactome" id="R-DME-6782210" name="Gap-filling DNA repair synthesis and ligation in TC-NER"/>
            <pathway-xref db="MetaCyc" id="PWY-8095" name="5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)"/>
            <pathway-xref db="MetaCyc" id="PWY-7465" name="3,3'-thiodipropanoate degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-6045" name="methylthiopropanonate degradation II (demethylation)"/>
            <pathway-xref db="MetaCyc" id="PWY-8077" name="ginkgotoxin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DRE-9664873" name="Pexophagy"/>
            <pathway-xref db="Reactome" id="R-DME-9013420" name="RHOU GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-8939242" name="RUNX1 regulates transcription of genes involved in differentiation of keratinocytes"/>
            <pathway-xref db="Reactome" id="R-MMU-5357905" name="Regulation of TNFR1 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-72163" name="mRNA Splicing - Major Pathway"/>
            <pathway-xref db="Reactome" id="R-DME-73856" name="RNA Polymerase II Transcription Termination"/>
            <pathway-xref db="Reactome" id="R-MMU-8866652" name="Synthesis of active ubiquitin: roles of E1 and E2 enzymes"/>
            <pathway-xref db="Reactome" id="R-CEL-3065679" name="SUMO is proteolytically processed"/>
            <pathway-xref db="Reactome" id="R-HSA-5357905" name="Regulation of TNFR1 signaling"/>
            <pathway-xref db="Reactome" id="R-DME-6804757" name="Regulation of TP53 Degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-2821" name="glucosinolate biosynthesis from phenylalanine"/>
            <pathway-xref db="MetaCyc" id="PWY-8231" name="Escherichia coli serotype O:127 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-XTR-5689603" name="UCH proteinases"/>
            <pathway-xref db="MetaCyc" id="PWY-7402" name="benzoate fermentation (to acetate and cyclohexane carboxylate)"/>
            <pathway-xref db="Reactome" id="R-MMU-9010553" name="Regulation of expression of SLITs and ROBOs"/>
            <pathway-xref db="Reactome" id="R-HSA-390471" name="Association of TriC/CCT with target proteins during biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="MetaCyc" id="PWY-7301" name="dTDP-4-O-demethyl-beta-L-noviose biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SCE-3065679" name="SUMO is proteolytically processed"/>
            <pathway-xref db="MetaCyc" id="PWY-8103" name="kavain biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-936440" name="Negative regulators of DDX58/IFIH1 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-5883" name="ephedrine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7714" name="harzianum A and trichodermin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DRE-5689896" name="Ovarian tumor domain proteases"/>
            <pathway-xref db="Reactome" id="R-MMU-6807004" name="Negative regulation of MET activity"/>
            <pathway-xref db="MetaCyc" id="PWY-8116" name="ochratoxin A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-6783310" name="Fanconi Anemia Pathway"/>
            <pathway-xref db="Reactome" id="R-DDI-8866652" name="Synthesis of active ubiquitin: roles of E1 and E2 enzymes"/>
            <pathway-xref db="MetaCyc" id="PWY-7483" name="elloramycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-8948751" name="Regulation of PTEN stability and activity"/>
            <pathway-xref db="MetaCyc" id="PWY-8184" name="L-isoleucine degradation III (oxidative Stickland reaction)"/>
            <pathway-xref db="MetaCyc" id="PWY-5987" name="sorgoleone biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7606" name="docosahexaenoate biosynthesis III (6-desaturase, mammals)"/>
            <pathway-xref db="Reactome" id="R-DDI-1474228" name="Degradation of the extracellular matrix"/>
            <pathway-xref db="Reactome" id="R-HSA-8948751" name="Regulation of PTEN stability and activity"/>
            <pathway-xref db="Reactome" id="R-HSA-5694530" name="Cargo concentration in the ER"/>
            <pathway-xref db="MetaCyc" id="PWY-8133" name="succinoglycan biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-81" name="toluene degradation to benzoyl-CoA (anaerobic)"/>
            <pathway-xref db="MetaCyc" id="PWY-7532" name="acetylaszonalenin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7564" name="bacimethrin and bacimethrin pyrophosphate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8096" name="5-methoxybenzimidazole biosynthesis (anaerobic)"/>
            <pathway-xref db="MetaCyc" id="PWY-8040" name="ansatrienin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8272" name="Escherichia coli serotype O:49 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-432720" name="Lysosome Vesicle Biogenesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8053" name="anandamide biosynthesis II"/>
            <pathway-xref db="Reactome" id="R-SCE-5656169" name="Termination of translesion DNA synthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6581" name="spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7591" name="okenone biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8049" name="pederin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-5689896" name="Ovarian tumor domain proteases"/>
            <pathway-xref db="Reactome" id="R-RNO-6809371" name="Formation of the cornified envelope"/>
            <pathway-xref db="Reactome" id="R-RNO-1592389" name="Activation of Matrix Metalloproteinases"/>
            <pathway-xref db="Reactome" id="R-MMU-9013424" name="RHOV GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DDI-114608" name="Platelet degranulation"/>
            <pathway-xref db="Reactome" id="R-MMU-201681" name="TCF dependent signaling in response to WNT"/>
            <pathway-xref db="MetaCyc" id="PWY-6036" name="cardenolide glucosides biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DRE-5689603" name="UCH proteinases"/>
            <pathway-xref db="Reactome" id="R-DME-532668" name="N-glycan trimming in the ER and Calnexin/Calreticulin cycle"/>
            <pathway-xref db="Reactome" id="R-SPO-5656169" name="Termination of translesion DNA synthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7025" name="gentamicin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-5696395" name="Formation of Incision Complex in GG-NER"/>
            <pathway-xref db="MetaCyc" id="PWY-6795" name="diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7612" name="chaetoglobosin A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-8951664" name="Neddylation"/>
            <pathway-xref db="MetaCyc" id="PWY-6373" name="acrylate degradation I"/>
            <pathway-xref db="MetaCyc" id="PWY-7671" name="saframycin A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-8948747" name="Regulation of PTEN localization"/>
            <pathway-xref db="MetaCyc" id="PWY-5305" name="bixin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-72187" name="mRNA 3'-end processing"/>
            <pathway-xref db="Reactome" id="R-CEL-204005" name="COPII-mediated vesicle transport"/>
            <pathway-xref db="MetaCyc" id="PWY-6153" name="autoinducer AI-2 biosynthesis I"/>
            <pathway-xref db="MetaCyc" id="PWY-7693" name="guadinomine B biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-8866652" name="Synthesis of active ubiquitin: roles of E1 and E2 enzymes"/>
            <pathway-xref db="Reactome" id="R-HSA-9648002" name="RAS processing"/>
            <pathway-xref db="Reactome" id="R-DDI-204005" name="COPII-mediated vesicle transport"/>
            <pathway-xref db="Reactome" id="R-HSA-9033241" name="Peroxisomal protein import"/>
            <pathway-xref db="MetaCyc" id="PWY-7461" name="hydroxycinnamate sugar acid ester biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7727" name="docosahexaenoate biosynthesis IV (4-desaturase, mammals)"/>
            <pathway-xref db="MetaCyc" id="PWY-6749" name="CMP-legionaminate biosynthesis I"/>
            <pathway-xref db="MetaCyc" id="PWY-7184" name="pyrimidine deoxyribonucleotides de novo biosynthesis I"/>
            <pathway-xref db="Reactome" id="R-SCE-5689603" name="UCH proteinases"/>
            <pathway-xref db="Reactome" id="R-MMU-9648002" name="RAS processing"/>
            <pathway-xref db="MetaCyc" id="PWY-8166" name="emodin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-1442490" name="Collagen degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-6312" name="barbaloin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7745" name="p-HBAD biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7653" name="griseofulvin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SPO-3065679" name="SUMO is proteolytically processed"/>
            <pathway-xref db="MetaCyc" id="PWY-7614" name="methiin metabolism"/>
            <pathway-xref db="Reactome" id="R-DDI-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="MetaCyc" id="PWY-8012" name="mupirocin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-5683826" name="Surfactant metabolism"/>
            <pathway-xref db="Reactome" id="R-CFA-2132295" name="MHC class II antigen presentation"/>
            <pathway-xref db="Reactome" id="R-RNO-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-HSA-9013424" name="RHOV GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-761" name="rhizobactin 1021 biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7989" name="acinetoferrin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7673" name="fusarin C biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6545" name="pyrimidine deoxyribonucleotides de novo biosynthesis III"/>
            <pathway-xref db="MetaCyc" id="PWY-7677" name="rosamicin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-4801" name="aloesone biosynthesis I"/>
            <pathway-xref db="MetaCyc" id="PWY-7171" name="flavonol acylglucoside biosynthesis II - isorhamnetin derivatives"/>
            <pathway-xref db="Reactome" id="R-DME-1592389" name="Activation of Matrix Metalloproteinases"/>
            <pathway-xref db="Reactome" id="R-CEL-2132295" name="MHC class II antigen presentation"/>
            <pathway-xref db="MetaCyc" id="PWY-7261" name="anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)"/>
            <pathway-xref db="MetaCyc" id="PWY-6286" name="spheroidene and spheroidenone biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-6781827" name="Transcription-Coupled Nucleotide Excision Repair (TC-NER)"/>
            <pathway-xref db="Reactome" id="R-MMU-140875" name="Common Pathway of Fibrin Clot Formation"/>
            <pathway-xref db="Reactome" id="R-CEL-5689603" name="UCH proteinases"/>
            <pathway-xref db="MetaCyc" id="PWY-7585" name="docosahexaenoate biosynthesis II (bacteria)"/>
            <pathway-xref db="MetaCyc" id="PWY-7563" name="bassianin and desmethylbassianin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-3542" name="choline biosynthesis II"/>
            <pathway-xref db="Reactome" id="R-DME-8948747" name="Regulation of PTEN localization"/>
            <pathway-xref db="Reactome" id="R-MMU-5696394" name="DNA Damage Recognition in GG-NER"/>
            <pathway-xref db="MetaCyc" id="PWY-6672" name="cis-geranyl-CoA degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7695" name="aurofusarin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7826" name="Amaryllidacea alkaloids biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-5357956" name="TNFR1-induced NFkappaB signaling pathway"/>
            <pathway-xref db="MetaCyc" id="PWY-7161" name="polymethylated quercetin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6722" name="candicidin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DDI-5694530" name="Cargo concentration in the ER"/>
            <pathway-xref db="MetaCyc" id="PWY-6739" name="pinitol biosynthesis II"/>
            <pathway-xref db="Reactome" id="R-SCE-532668" name="N-glycan trimming in the ER and Calnexin/Calreticulin cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-5706" name="alliin metabolism"/>
            <pathway-xref db="Reactome" id="R-HSA-380259" name="Loss of Nlp from mitotic centrosomes"/>
            <pathway-xref db="Reactome" id="R-DDI-8948751" name="Regulation of PTEN stability and activity"/>
            <pathway-xref db="MetaCyc" id="PWY-5353" name="arachidonate biosynthesis I (6-desaturase, lower eukaryotes)"/>
            <pathway-xref db="Reactome" id="R-CEL-2022377" name="Metabolism of Angiotensinogen to Angiotensins"/>
            <pathway-xref db="MetaCyc" id="PWY-6995" name="5-hydroxymethylfurfural degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7679" name="anthocyanidin acylglucoside and acylsambubioside biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5773" name="gossypol biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DRE-5620912" name="Anchoring of the basal body to the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-HSA-5633231" name="Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS)"/>
            <pathway-xref db="Reactome" id="R-CEL-9013404" name="RAC2 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-7702" name="sch210971 and sch210972 biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-532668" name="N-glycan trimming in the ER and Calnexin/Calreticulin cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-5689603" name="UCH proteinases"/>
            <pathway-xref db="MetaCyc" id="PWY-7292" name="oleate beta-oxidation (thioesterase-dependent, yeast)"/>
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            <pathway-xref db="MetaCyc" id="PWY-6958" name="icosapentaenoate biosynthesis I (lower eukaryotes)"/>
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            <pathway-xref db="MetaCyc" id="PWY-6148" name="tetrahydromethanopterin biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-8257" name="Escherichia coli serotype O:52 O antigen biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-4922" name="6-methoxymellein biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-7667" name="apicidin biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-GGA-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7691" name="10,13-epoxy-11-methyl-octadecadienoate biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-8045" name="cylindrospermopsin biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-5400" name="amaranthin biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-BTA-2132295" name="MHC class II antigen presentation"/>
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            <pathway-xref db="Reactome" id="R-HSA-6783310" name="Fanconi Anemia Pathway"/>
            <pathway-xref db="MetaCyc" id="PWY-8026" name="sterol biosynthesis (methylotrophs)"/>
            <pathway-xref db="Reactome" id="R-CEL-6782210" name="Gap-filling DNA repair synthesis and ligation in TC-NER"/>
            <pathway-xref db="Reactome" id="R-HSA-8939242" name="RUNX1 regulates transcription of genes involved in differentiation of keratinocytes"/>
            <pathway-xref db="MetaCyc" id="PWY-7168" name="flavonol acylglucoside biosynthesis I - kaempferol derivatives"/>
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            <pathway-xref db="Reactome" id="R-SPO-6781823" name="Formation of TC-NER Pre-Incision Complex"/>
            <pathway-xref db="MetaCyc" id="PWY-7719" name="CMP-diacetamido-8-epilegionaminic acid biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7690" name="holomycin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7817" name="type I lipoteichoic acid biosynthesis (S. aureus)"/>
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            <pathway-xref db="MetaCyc" id="PWY-5307" name="gentiodelphin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-PFA-8866652" name="Synthesis of active ubiquitin: roles of E1 and E2 enzymes"/>
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            <pathway-xref db="MetaCyc" id="PWY-7076" name="3,5-dimethoxytoluene biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-5694530" name="Cargo concentration in the ER"/>
            <pathway-xref db="MetaCyc" id="PWY-8210" name="pyrrolomycin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6346" name="staurosporine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SPO-110314" name="Recognition of DNA damage by PCNA-containing replication complex"/>
            <pathway-xref db="MetaCyc" id="PWY-5292" name="vindoline, vindorosine and vinblastine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7440" name="dTDP-beta-L-4-epi-vancosamine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-8866652" name="Synthesis of active ubiquitin: roles of E1 and E2 enzymes"/>
            <pathway-xref db="MetaCyc" id="PWY-7280" name="ternatin C3 biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DRE-380259" name="Loss of Nlp from mitotic centrosomes"/>
            <pathway-xref db="MetaCyc" id="PWY-5301" name="ajmaline and sarpagine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-8948747" name="Regulation of PTEN localization"/>
            <pathway-xref db="Reactome" id="R-DME-5689603" name="UCH proteinases"/>
            <pathway-xref db="Reactome" id="R-HSA-2173795" name="Downregulation of SMAD2/3:SMAD4 transcriptional activity"/>
            <pathway-xref db="Reactome" id="R-CFA-1592389" name="Activation of Matrix Metalloproteinases"/>
            <pathway-xref db="Reactome" id="R-HSA-1169408" name="ISG15 antiviral mechanism"/>
            <pathway-xref db="Reactome" id="R-MMU-1679131" name="Trafficking and processing of endosomal TLR"/>
            <pathway-xref db="Reactome" id="R-MMU-9013420" name="RHOU GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-7984" name="acinetobactin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6027" name="capsiconiate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SPO-9648002" name="RAS processing"/>
            <pathway-xref db="Reactome" id="R-HSA-5689896" name="Ovarian tumor domain proteases"/>
            <pathway-xref db="Reactome" id="R-MMU-432720" name="Lysosome Vesicle Biogenesis"/>
            <pathway-xref db="Reactome" id="R-CEL-1592389" name="Activation of Matrix Metalloproteinases"/>
            <pathway-xref db="MetaCyc" id="PWY-7907" name="(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-5689896" name="Ovarian tumor domain proteases"/>
            <pathway-xref db="Reactome" id="R-SCE-6782135" name="Dual incision in TC-NER"/>
            <pathway-xref db="Reactome" id="R-RNO-532668" name="N-glycan trimming in the ER and Calnexin/Calreticulin cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-6785807" name="Interleukin-4 and Interleukin-13 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-7555" name="alpha-cyclopiazonate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-351906" name="Apoptotic cleavage of cell adhesion proteins"/>
            <pathway-xref db="MetaCyc" id="PWY-7954" name="tabtoxinine-beta-lactam biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-2132295" name="MHC class II antigen presentation"/>
            <pathway-xref db="MetaCyc" id="PWY-7608" name="neoxaline biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9678110" name="Attachment and Entry"/>
            <pathway-xref db="Reactome" id="R-SSC-1592389" name="Activation of Matrix Metalloproteinases"/>
            <pathway-xref db="MetaCyc" id="PWY-7501" name="phosphatidylserine biosynthesis I"/>
          </entry>
          <signature-library-release library="SUPERFAMILY" version="1.75"/>
        </signature>
        <model-ac>0041295</model-ac>
        <locations>
          <superfamilyhmmer3-location hmm-length="347" start="21" end="353">
            <location-fragments>
              <superfamilyhmmer3-location-fragment start="21" end="353" dc-status="CONTINUOUS"/>
            </location-fragments>
          </superfamilyhmmer3-location>
        </locations>
      </superfamilyhmmer3-match>
    </matches>
  </protein>
  <protein>
    <sequence md5="04fce3211f753d365a9e1149c0114cc3">MDLLYGYSVRESYRHLFYIYRAKSLRTPSNLFVVNLAFCDFIMMLKAPIFIYNSFNTGFATGHLGCQIFACMGALSGIGAGMTNAAIAYDRYSTIARPLDGKLSRGQVMLLIVLIWTYTIPWALMPLMHVWGRFVPEGFLTSCTFDYLTDTPEIRYFVATIFTFSYCIPMSFIIYYYSQIVSHVVNHEKALREQAKKMNVESLRSNANTNAQSAEIRIAKAAITICFLFVLSWTPYGTLAMIGAFGNKALLTPGVTMIPACTCKFVACLDPYVYAISHPRYRLELQKRLPWLELQEKPVADTQSTTTEMVNASSSS</sequence>
    <xref id="XP_029177330.1" name="XP_029177330.1 opsin, ultraviolet-sensitive isoform X2 [Nylanderia fulva]"/>
    <matches>
      <fingerprints-match evalue="4.2E-34" graphscan="..IIIII">
        <signature ac="PR00577" desc="Opsin RH3/RH4 signature" name="OPSINRH3RH4">
          <entry ac="IPR000856" desc="Opsin RH3/RH4" name="Opsin_RH3/RH4" type="FAMILY">
            <go-xref category="BIOLOGICAL_PROCESS" db="GO" id="GO:0007601" name="visual perception"/>
            <go-xref category="CELLULAR_COMPONENT" db="GO" id="GO:0016021" name="integral component of membrane"/>
            <go-xref category="BIOLOGICAL_PROCESS" db="GO" id="GO:0007602" name="phototransduction"/>
            <go-xref category="BIOLOGICAL_PROCESS" db="GO" id="GO:0007186" name="G protein-coupled receptor signaling pathway"/>
          </entry>
          <signature-library-release library="PRINTS" version="42.0"/>
        </signature>
        <model-ac>PR00577</model-ac>
        <locations>
          <fingerprints-location motifNumber="3" pvalue="1.6E-7" score="78.12" start="51" end="62">
            <location-fragments>
              <fingerprints-location-fragment start="51" end="62" dc-status="CONTINUOUS"/>
            </location-fragments>
          </fingerprints-location>
          <fingerprints-location motifNumber="5" pvalue="1.08E-9" score="72.22" start="170" end="187">
            <location-fragments>
              <fingerprints-location-fragment start="170" end="187" dc-status="CONTINUOUS"/>
            </location-fragments>
          </fingerprints-location>
          <fingerprints-location motifNumber="6" pvalue="8.93E-8" score="68.33" start="205" end="219">
            <location-fragments>
              <fingerprints-location-fragment start="205" end="219" dc-status="CONTINUOUS"/>
            </location-fragments>
          </fingerprints-location>
          <fingerprints-location motifNumber="7" pvalue="8.11E-10" score="72.37" start="282" end="300">
            <location-fragments>
              <fingerprints-location-fragment start="282" end="300" dc-status="CONTINUOUS"/>
            </location-fragments>
          </fingerprints-location>
          <fingerprints-location motifNumber="4" pvalue="3.14E-8" score="69.17" start="147" end="161">
            <location-fragments>
              <fingerprints-location-fragment start="147" end="161" dc-status="CONTINUOUS"/>
            </location-fragments>
          </fingerprints-location>
        </locations>
      </fingerprints-match>
      <fingerprints-match evalue="4.4E-19" graphscan=".iiiiii">
        <signature ac="PR00237" desc="Rhodopsin-like GPCR superfamily signature" name="GPCRRHODOPSN">
          <entry ac="IPR000276" desc="G protein-coupled receptor, rhodopsin-like" name="GPCR_Rhodpsn" type="FAMILY">
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            <go-xref category="CELLULAR_COMPONENT" db="GO" id="GO:0016021" name="integral component of membrane"/>
            <go-xref category="BIOLOGICAL_PROCESS" db="GO" id="GO:0007186" name="G protein-coupled receptor signaling pathway"/>
            <pathway-xref db="Reactome" id="R-BTA-373076" name="Class A/1 (Rhodopsin-like receptors)"/>
            <pathway-xref db="Reactome" id="R-HSA-187024" name="NGF-independant TRKA activation"/>
            <pathway-xref db="Reactome" id="R-RNO-418555" name="G alpha (s) signalling events"/>
            <pathway-xref db="Reactome" id="R-MMU-376176" name="Signaling by ROBO receptors"/>
            <pathway-xref db="Reactome" id="R-HSA-389397" name="Orexin and neuropeptides FF and QRFP bind to their respective receptors"/>
            <pathway-xref db="Reactome" id="R-MMU-392170" name="ADP signalling through P2Y purinoceptor 12"/>
            <pathway-xref db="Reactome" id="R-HSA-5619099" name="Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI)"/>
            <pathway-xref db="Reactome" id="R-RNO-419408" name="Lysosphingolipid and LPA receptors"/>
            <pathway-xref db="Reactome" id="R-MMU-375281" name="Hormone ligand-binding receptors"/>
            <pathway-xref db="Reactome" id="R-MMU-418597" name="G alpha (z) signalling events"/>
            <pathway-xref db="Reactome" id="R-SSC-419771" name="Opsins"/>
            <pathway-xref db="Reactome" id="R-CEL-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-RNO-2485179" name="Activation of the phototransduction cascade"/>
            <pathway-xref db="Reactome" id="R-MMU-432040" name="Vasopressin regulates renal water homeostasis via Aquaporins"/>
            <pathway-xref db="Reactome" id="R-MMU-392023" name="Adrenaline signalling through Alpha-2 adrenergic receptor"/>
            <pathway-xref db="Reactome" id="R-RNO-418592" name="ADP signalling through P2Y purinoceptor 1"/>
            <pathway-xref db="Reactome" id="R-HSA-877300" name="Interferon gamma signaling"/>
            <pathway-xref db="Reactome" id="R-DME-400042" name="Adrenaline,noradrenaline inhibits insulin secretion"/>
            <pathway-xref db="Reactome" id="R-DME-418594" name="G alpha (i) signalling events"/>
            <pathway-xref db="Reactome" id="R-GGA-375276" name="Peptide ligand-binding receptors"/>
            <pathway-xref db="Reactome" id="R-MMU-373076" name="Class A/1 (Rhodopsin-like receptors)"/>
            <pathway-xref db="Reactome" id="R-RNO-2187335" name="The retinoid cycle in cones (daylight vision)"/>
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            <pathway-xref db="Reactome" id="R-DME-375276" name="Peptide ligand-binding receptors"/>
            <pathway-xref db="Reactome" id="R-RNO-444821" name="Relaxin receptors"/>
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            <pathway-xref db="Reactome" id="R-GGA-373076" name="Class A/1 (Rhodopsin-like receptors)"/>
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            <pathway-xref db="Reactome" id="R-MMU-390651" name="Dopamine receptors"/>
            <pathway-xref db="Reactome" id="R-MMU-5689880" name="Ub-specific processing proteases"/>
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            <pathway-xref db="Reactome" id="R-MMU-9706019" name="RHOBTB3 ATPase cycle"/>
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            <pathway-xref db="Reactome" id="R-MMU-2453902" name="The canonical retinoid cycle in rods (twilight vision)"/>
            <pathway-xref db="Reactome" id="R-DRE-5620916" name="VxPx cargo-targeting to cilium"/>
            <pathway-xref db="Reactome" id="R-HSA-419771" name="Opsins"/>
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            <pathway-xref db="Reactome" id="R-RNO-392851" name="Prostacyclin signalling through prostacyclin receptor"/>
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            <pathway-xref db="Reactome" id="R-RNO-444209" name="Free fatty acid receptors"/>
            <pathway-xref db="Reactome" id="R-RNO-456926" name="Thrombin signalling through proteinase activated receptors (PARs)"/>
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            <pathway-xref db="Reactome" id="R-CEL-418597" name="G alpha (z) signalling events"/>
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            <pathway-xref db="Reactome" id="R-BTA-417973" name="Adenosine P1 receptors"/>
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            <pathway-xref db="Reactome" id="R-RNO-428930" name="Thromboxane signalling through TP receptor"/>
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            <pathway-xref db="Reactome" id="R-RNO-163359" name="Glucagon signaling in metabolic regulation"/>
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            <pathway-xref db="Reactome" id="R-HSA-9660821" name="ADORA2B mediated anti-inflammatory cytokines production"/>
            <pathway-xref db="Reactome" id="R-CEL-418594" name="G alpha (i) signalling events"/>
            <pathway-xref db="Reactome" id="R-RNO-391906" name="Leukotriene receptors"/>
            <pathway-xref db="Reactome" id="R-DME-390650" name="Histamine receptors"/>
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            <pathway-xref db="Reactome" id="R-HSA-391903" name="Eicosanoid ligand-binding receptors"/>
            <pathway-xref db="Reactome" id="R-SSC-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-HSA-5683826" name="Surfactant metabolism"/>
            <pathway-xref db="Reactome" id="R-RNO-375276" name="Peptide ligand-binding receptors"/>
            <pathway-xref db="Reactome" id="R-DRE-5632684" name="Hedgehog 'on' state"/>
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            <pathway-xref db="Reactome" id="R-RNO-9706019" name="RHOBTB3 ATPase cycle"/>
            <pathway-xref db="Reactome" id="R-DME-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-CEL-390651" name="Dopamine receptors"/>
            <pathway-xref db="Reactome" id="R-HSA-444209" name="Free fatty acid receptors"/>
            <pathway-xref db="Reactome" id="R-CFA-390666" name="Serotonin receptors"/>
            <pathway-xref db="Reactome" id="R-RNO-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-CEL-390650" name="Histamine receptors"/>
            <pathway-xref db="Reactome" id="R-MMU-4641263" name="Regulation of FZD by ubiquitination"/>
            <pathway-xref db="Reactome" id="R-BTA-375281" name="Hormone ligand-binding receptors"/>
            <pathway-xref db="Reactome" id="R-DRE-416476" name="G alpha (q) signalling events"/>
            <pathway-xref db="Reactome" id="R-CFA-391908" name="Prostanoid ligand receptors"/>
            <pathway-xref db="Reactome" id="R-DME-9706019" name="RHOBTB3 ATPase cycle"/>
            <pathway-xref db="Reactome" id="R-CEL-416476" name="G alpha (q) signalling events"/>
            <pathway-xref db="Reactome" id="R-HSA-391908" name="Prostanoid ligand receptors"/>
            <pathway-xref db="Reactome" id="R-DRE-375280" name="Amine ligand-binding receptors"/>
            <pathway-xref db="Reactome" id="R-SSC-8856828" name="Clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-HSA-6785807" name="Interleukin-4 and Interleukin-13 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-399997" name="Acetylcholine regulates insulin secretion"/>
            <pathway-xref db="Reactome" id="R-HSA-373076" name="Class A/1 (Rhodopsin-like receptors)"/>
            <pathway-xref db="Reactome" id="R-MMU-418555" name="G alpha (s) signalling events"/>
            <pathway-xref db="Reactome" id="R-RNO-419771" name="Opsins"/>
            <pathway-xref db="Reactome" id="R-GGA-416476" name="G alpha (q) signalling events"/>
            <pathway-xref db="Reactome" id="R-CEL-8856828" name="Clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-DRE-977606" name="Regulation of Complement cascade"/>
            <pathway-xref db="Reactome" id="R-MMU-418592" name="ADP signalling through P2Y purinoceptor 1"/>
          </entry>
          <signature-library-release library="PROSITE_PATTERNS" version="2021_01"/>
        </signature>
        <model-ac>PS00237</model-ac>
        <locations>
          <patternscan-location level="STRONG" start="79" end="95">
            <location-fragments>
              <patternscan-location-fragment start="79" end="95" dc-status="CONTINUOUS"/>
            </location-fragments>
            <alignment>GAGmTNAAIAYDRYStI</alignment>
          </patternscan-location>
        </locations>
      </patternscan-match>
      <profilescan-match>
        <signature ac="PS50262" desc="G-protein coupled receptors family 1 profile." name="G_PROTEIN_RECEP_F1_2">
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            <pathway-xref db="Reactome" id="R-BTA-373076" name="Class A/1 (Rhodopsin-like receptors)"/>
            <pathway-xref db="Reactome" id="R-HSA-187024" name="NGF-independant TRKA activation"/>
            <pathway-xref db="Reactome" id="R-RNO-418555" name="G alpha (s) signalling events"/>
            <pathway-xref db="Reactome" id="R-MMU-376176" name="Signaling by ROBO receptors"/>
            <pathway-xref db="Reactome" id="R-HSA-389397" name="Orexin and neuropeptides FF and QRFP bind to their respective receptors"/>
            <pathway-xref db="Reactome" id="R-MMU-392170" name="ADP signalling through P2Y purinoceptor 12"/>
            <pathway-xref db="Reactome" id="R-HSA-5619099" name="Defective AVP does not bind AVPR1A,B and causes neurohypophyseal diabetes insipidus (NDI)"/>
            <pathway-xref db="Reactome" id="R-RNO-419408" name="Lysosphingolipid and LPA receptors"/>
            <pathway-xref db="Reactome" id="R-MMU-375281" name="Hormone ligand-binding receptors"/>
            <pathway-xref db="Reactome" id="R-MMU-418597" name="G alpha (z) signalling events"/>
            <pathway-xref db="Reactome" id="R-SSC-419771" name="Opsins"/>
            <pathway-xref db="Reactome" id="R-CEL-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-RNO-2485179" name="Activation of the phototransduction cascade"/>
            <pathway-xref db="Reactome" id="R-MMU-432040" name="Vasopressin regulates renal water homeostasis via Aquaporins"/>
            <pathway-xref db="Reactome" id="R-MMU-392023" name="Adrenaline signalling through Alpha-2 adrenergic receptor"/>
            <pathway-xref db="Reactome" id="R-RNO-418592" name="ADP signalling through P2Y purinoceptor 1"/>
            <pathway-xref db="Reactome" id="R-HSA-877300" name="Interferon gamma signaling"/>
            <pathway-xref db="Reactome" id="R-DME-400042" name="Adrenaline,noradrenaline inhibits insulin secretion"/>
            <pathway-xref db="Reactome" id="R-DME-418594" name="G alpha (i) signalling events"/>
            <pathway-xref db="Reactome" id="R-GGA-375276" name="Peptide ligand-binding receptors"/>
            <pathway-xref db="Reactome" id="R-MMU-373076" name="Class A/1 (Rhodopsin-like receptors)"/>
            <pathway-xref db="Reactome" id="R-RNO-2187335" name="The retinoid cycle in cones (daylight vision)"/>
            <pathway-xref db="Reactome" id="R-HSA-2514859" name="Inactivation, recovery and regulation of the phototransduction cascade"/>
            <pathway-xref db="Reactome" id="R-MMU-419771" name="Opsins"/>
            <pathway-xref db="Reactome" id="R-RNO-2514859" name="Inactivation, recovery and regulation of the phototransduction cascade"/>
            <pathway-xref db="Reactome" id="R-DRE-5610787" name="Hedgehog 'off' state"/>
            <pathway-xref db="Reactome" id="R-HSA-977606" name="Regulation of Complement cascade"/>
            <pathway-xref db="Reactome" id="R-RNO-202040" name="G-protein activation"/>
            <pathway-xref db="Reactome" id="R-MMU-5632684" name="Hedgehog 'on' state"/>
            <pathway-xref db="Reactome" id="R-HSA-388479" name="Vasopressin-like receptors"/>
            <pathway-xref db="Reactome" id="R-HSA-392170" name="ADP signalling through P2Y purinoceptor 12"/>
            <pathway-xref db="Reactome" id="R-HSA-2187335" name="The retinoid cycle in cones (daylight vision)"/>
            <pathway-xref db="Reactome" id="R-DRE-375276" name="Peptide ligand-binding receptors"/>
            <pathway-xref db="Reactome" id="R-DME-375276" name="Peptide ligand-binding receptors"/>
            <pathway-xref db="Reactome" id="R-RNO-444821" name="Relaxin receptors"/>
            <pathway-xref db="Reactome" id="R-RNO-390648" name="Muscarinic acetylcholine receptors"/>
            <pathway-xref db="Reactome" id="R-MMU-2514859" name="Inactivation, recovery and regulation of the phototransduction cascade"/>
            <pathway-xref db="Reactome" id="R-MMU-420092" name="Glucagon-type ligand receptors"/>
            <pathway-xref db="Reactome" id="R-HSA-2485179" name="Activation of the phototransduction cascade"/>
            <pathway-xref db="Reactome" id="R-DRE-392023" name="Adrenaline signalling through Alpha-2 adrenergic receptor"/>
            <pathway-xref db="Reactome" id="R-GGA-373076" name="Class A/1 (Rhodopsin-like receptors)"/>
            <pathway-xref db="Reactome" id="R-MMU-381771" name="Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)"/>
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            <pathway-xref db="Reactome" id="R-CEL-202040" name="G-protein activation"/>
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            <pathway-xref db="Reactome" id="R-BTA-390651" name="Dopamine receptors"/>
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            <pathway-xref db="Reactome" id="R-MMU-456926" name="Thrombin signalling through proteinase activated receptors (PARs)"/>
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            <pathway-xref db="Reactome" id="R-MMU-390648" name="Muscarinic acetylcholine receptors"/>
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            <pathway-xref db="Reactome" id="R-HSA-5620916" name="VxPx cargo-targeting to cilium"/>
            <pathway-xref db="Reactome" id="R-MMU-163359" name="Glucagon signaling in metabolic regulation"/>
            <pathway-xref db="Reactome" id="R-BTA-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-BTA-419408" name="Lysosphingolipid and LPA receptors"/>
            <pathway-xref db="Reactome" id="R-HSA-390696" name="Adrenoceptors"/>
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            <pathway-xref db="Reactome" id="R-MMU-428930" name="Thromboxane signalling through TP receptor"/>
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            <pathway-xref db="Reactome" id="R-HSA-9022699" name="MECP2 regulates neuronal receptors and channels"/>
            <pathway-xref db="Reactome" id="R-RNO-392170" name="ADP signalling through P2Y purinoceptor 12"/>
            <pathway-xref db="Reactome" id="R-HSA-391906" name="Leukotriene receptors"/>
            <pathway-xref db="Reactome" id="R-MMU-391908" name="Prostanoid ligand receptors"/>
            <pathway-xref db="Reactome" id="R-DME-390651" name="Dopamine receptors"/>
            <pathway-xref db="Reactome" id="R-HSA-444821" name="Relaxin receptors"/>
            <pathway-xref db="Reactome" id="R-BTA-390648" name="Muscarinic acetylcholine receptors"/>
            <pathway-xref db="Reactome" id="R-RNO-388479" name="Vasopressin-like receptors"/>
            <pathway-xref db="Reactome" id="R-BTA-390696" name="Adrenoceptors"/>
            <pathway-xref db="Reactome" id="R-DME-390666" name="Serotonin receptors"/>
            <pathway-xref db="Reactome" id="R-RNO-977606" name="Regulation of Complement cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-8856828" name="Clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-HSA-202040" name="G-protein activation"/>
            <pathway-xref db="Reactome" id="R-DRE-2453902" name="The canonical retinoid cycle in rods (twilight vision)"/>
            <pathway-xref db="Reactome" id="R-BTA-418555" name="G alpha (s) signalling events"/>
            <pathway-xref db="Reactome" id="R-CEL-400042" name="Adrenaline,noradrenaline inhibits insulin secretion"/>
            <pathway-xref db="Reactome" id="R-CFA-416476" name="G alpha (q) signalling events"/>
            <pathway-xref db="Reactome" id="R-MMU-5683826" name="Surfactant metabolism"/>
            <pathway-xref db="Reactome" id="R-SSC-418594" name="G alpha (i) signalling events"/>
            <pathway-xref db="Reactome" id="R-MMU-418594" name="G alpha (i) signalling events"/>
            <pathway-xref db="Reactome" id="R-DME-419771" name="Opsins"/>
            <pathway-xref db="Reactome" id="R-MMU-444473" name="Formyl peptide receptors bind formyl peptides and many other ligands"/>
            <pathway-xref db="Reactome" id="R-GGA-418555" name="G alpha (s) signalling events"/>
            <pathway-xref db="Reactome" id="R-HSA-416476" name="G alpha (q) signalling events"/>
            <pathway-xref db="Reactome" id="R-DRE-419408" name="Lysosphingolipid and LPA receptors"/>
            <pathway-xref db="Reactome" id="R-DRE-418555" name="G alpha (s) signalling events"/>
            <pathway-xref db="Reactome" id="R-BTA-391908" name="Prostanoid ligand receptors"/>
            <pathway-xref db="Reactome" id="R-CEL-391908" name="Prostanoid ligand receptors"/>
            <pathway-xref db="Reactome" id="R-SSC-418555" name="G alpha (s) signalling events"/>
            <pathway-xref db="Reactome" id="R-HSA-163359" name="Glucagon signaling in metabolic regulation"/>
            <pathway-xref db="Reactome" id="R-MMU-381753" name="Olfactory Signaling Pathway"/>
            <pathway-xref db="Reactome" id="R-HSA-881907" name="Gastrin-CREB signalling pathway via PKC and MAPK"/>
            <pathway-xref db="Reactome" id="R-RNO-5620922" name="BBSome-mediated cargo-targeting to cilium"/>
            <pathway-xref db="Reactome" id="R-BTA-2453902" name="The canonical retinoid cycle in rods (twilight vision)"/>
            <pathway-xref db="Reactome" id="R-HSA-9609690" name="HCMV Early Events"/>
            <pathway-xref db="Reactome" id="R-MMU-375280" name="Amine ligand-binding receptors"/>
            <pathway-xref db="Reactome" id="R-MMU-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-HSA-428930" name="Thromboxane signalling through TP receptor"/>
            <pathway-xref db="Reactome" id="R-XTR-380108" name="Chemokine receptors bind chemokines"/>
            <pathway-xref db="Reactome" id="R-RNO-3296197" name="Hydroxycarboxylic acid-binding receptors"/>
            <pathway-xref db="Reactome" id="R-RNO-390666" name="Serotonin receptors"/>
            <pathway-xref db="Reactome" id="R-DME-418555" name="G alpha (s) signalling events"/>
            <pathway-xref db="Reactome" id="R-MMU-390696" name="Adrenoceptors"/>
            <pathway-xref db="Reactome" id="R-HSA-390651" name="Dopamine receptors"/>
            <pathway-xref db="Reactome" id="R-MMU-444821" name="Relaxin receptors"/>
            <pathway-xref db="Reactome" id="R-HSA-420499" name="Class C/3 (Metabotropic glutamate/pheromone receptors)"/>
            <pathway-xref db="Reactome" id="R-RNO-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-MMU-434316" name="Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion"/>
            <pathway-xref db="Reactome" id="R-GGA-418592" name="ADP signalling through P2Y purinoceptor 1"/>
            <pathway-xref db="Reactome" id="R-GGA-390648" name="Muscarinic acetylcholine receptors"/>
            <pathway-xref db="Reactome" id="R-MMU-8856828" name="Clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-HSA-6783783" name="Interleukin-10 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-417957" name="P2Y receptors"/>
            <pathway-xref db="Reactome" id="R-BTA-380108" name="Chemokine receptors bind chemokines"/>
            <pathway-xref db="Reactome" id="R-BTA-417957" name="P2Y receptors"/>
            <pathway-xref db="Reactome" id="R-HSA-390666" name="Serotonin receptors"/>
            <pathway-xref db="Reactome" id="R-RNO-400042" name="Adrenaline,noradrenaline inhibits insulin secretion"/>
            <pathway-xref db="Reactome" id="R-HSA-381753" name="Olfactory Signaling Pathway"/>
            <pathway-xref db="Reactome" id="R-MMU-416476" name="G alpha (q) signalling events"/>
            <pathway-xref db="Reactome" id="R-DME-418597" name="G alpha (z) signalling events"/>
            <pathway-xref db="Reactome" id="R-RNO-417973" name="Adenosine P1 receptors"/>
            <pathway-xref db="Reactome" id="R-SSC-2514859" name="Inactivation, recovery and regulation of the phototransduction cascade"/>
            <pathway-xref db="Reactome" id="R-SSC-2485179" name="Activation of the phototransduction cascade"/>
            <pathway-xref db="Reactome" id="R-RNO-111885" name="Opioid Signalling"/>
            <pathway-xref db="Reactome" id="R-MMU-5620922" name="BBSome-mediated cargo-targeting to cilium"/>
            <pathway-xref db="Reactome" id="R-HSA-418594" name="G alpha (i) signalling events"/>
            <pathway-xref db="Reactome" id="R-MMU-375276" name="Peptide ligand-binding receptors"/>
            <pathway-xref db="Reactome" id="R-DRE-2485179" name="Activation of the phototransduction cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-111885" name="Opioid Signalling"/>
            <pathway-xref db="Reactome" id="R-HSA-9706019" name="RHOBTB3 ATPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-4641263" name="Regulation of FZD by ubiquitination"/>
            <pathway-xref db="Reactome" id="R-BTA-5620916" name="VxPx cargo-targeting to cilium"/>
            <pathway-xref db="Reactome" id="R-BTA-375276" name="Peptide ligand-binding receptors"/>
            <pathway-xref db="Reactome" id="R-SSC-416476" name="G alpha (q) signalling events"/>
            <pathway-xref db="Reactome" id="R-RNO-420499" name="Class C/3 (Metabotropic glutamate/pheromone receptors)"/>
            <pathway-xref db="Reactome" id="R-RNO-390651" name="Dopamine receptors"/>
            <pathway-xref db="Reactome" id="R-HSA-9660826" name="Purinergic signaling in leishmaniasis infection"/>
            <pathway-xref db="Reactome" id="R-MMU-400511" name="Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)"/>
            <pathway-xref db="Reactome" id="R-RNO-416482" name="G alpha (12/13) signalling events"/>
            <pathway-xref db="Reactome" id="R-HSA-432040" name="Vasopressin regulates renal water homeostasis via Aquaporins"/>
            <pathway-xref db="Reactome" id="R-BTA-5683826" name="Surfactant metabolism"/>
            <pathway-xref db="Reactome" id="R-CFA-381753" name="Olfactory Signaling Pathway"/>
            <pathway-xref db="Reactome" id="R-MMU-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-BTA-418594" name="G alpha (i) signalling events"/>
            <pathway-xref db="Reactome" id="R-RNO-2453902" name="The canonical retinoid cycle in rods (twilight vision)"/>
            <pathway-xref db="Reactome" id="R-DRE-2514859" name="Inactivation, recovery and regulation of the phototransduction cascade"/>
            <pathway-xref db="Reactome" id="R-CFA-5683826" name="Surfactant metabolism"/>
            <pathway-xref db="Reactome" id="R-MMU-416482" name="G alpha (12/13) signalling events"/>
            <pathway-xref db="Reactome" id="R-HSA-140875" name="Common Pathway of Fibrin Clot Formation"/>
            <pathway-xref db="Reactome" id="R-MMU-380095" name="Tachykinin receptors bind tachykinins"/>
            <pathway-xref db="Reactome" id="R-MMU-391906" name="Leukotriene receptors"/>
            <pathway-xref db="Reactome" id="R-MMU-417957" name="P2Y receptors"/>
            <pathway-xref db="Reactome" id="R-HSA-434316" name="Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion"/>
            <pathway-xref db="Reactome" id="R-DRE-2187335" name="The retinoid cycle in cones (daylight vision)"/>
            <pathway-xref db="Reactome" id="R-HSA-380108" name="Chemokine receptors bind chemokines"/>
            <pathway-xref db="Reactome" id="R-RNO-381771" name="Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)"/>
            <pathway-xref db="Reactome" id="R-MMU-417973" name="Adenosine P1 receptors"/>
            <pathway-xref db="Reactome" id="R-HSA-9679191" name="Potential therapeutics for SARS"/>
            <pathway-xref db="Reactome" id="R-RNO-140875" name="Common Pathway of Fibrin Clot Formation"/>
            <pathway-xref db="Reactome" id="R-MMU-400042" name="Adrenaline,noradrenaline inhibits insulin secretion"/>
            <pathway-xref db="Reactome" id="R-SSC-419408" name="Lysosphingolipid and LPA receptors"/>
            <pathway-xref db="Reactome" id="R-DME-392023" name="Adrenaline signalling through Alpha-2 adrenergic receptor"/>
            <pathway-xref db="Reactome" id="R-DRE-419771" name="Opsins"/>
            <pathway-xref db="Reactome" id="R-RNO-375280" name="Amine ligand-binding receptors"/>
            <pathway-xref db="Reactome" id="R-HSA-2453902" name="The canonical retinoid cycle in rods (twilight vision)"/>
            <pathway-xref db="Reactome" id="R-RNO-416476" name="G alpha (q) signalling events"/>
            <pathway-xref db="Reactome" id="R-DME-373076" name="Class A/1 (Rhodopsin-like receptors)"/>
            <pathway-xref db="Reactome" id="R-RNO-390650" name="Histamine receptors"/>
            <pathway-xref db="Reactome" id="R-MMU-392851" name="Prostacyclin signalling through prostacyclin receptor"/>
            <pathway-xref db="Reactome" id="R-SSC-5620916" name="VxPx cargo-targeting to cilium"/>
            <pathway-xref db="Reactome" id="R-CFA-380108" name="Chemokine receptors bind chemokines"/>
            <pathway-xref db="Reactome" id="R-HSA-418597" name="G alpha (z) signalling events"/>
            <pathway-xref db="Reactome" id="R-DRE-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-GGA-417973" name="Adenosine P1 receptors"/>
            <pathway-xref db="Reactome" id="R-CEL-5620922" name="BBSome-mediated cargo-targeting to cilium"/>
            <pathway-xref db="Reactome" id="R-DME-381753" name="Olfactory Signaling Pathway"/>
            <pathway-xref db="Reactome" id="R-DRE-400042" name="Adrenaline,noradrenaline inhibits insulin secretion"/>
            <pathway-xref db="Reactome" id="R-MMU-2485179" name="Activation of the phototransduction cascade"/>
            <pathway-xref db="Reactome" id="R-BTA-391906" name="Leukotriene receptors"/>
            <pathway-xref db="Reactome" id="R-MMU-202040" name="G-protein activation"/>
            <pathway-xref db="Reactome" id="R-RNO-432040" name="Vasopressin regulates renal water homeostasis via Aquaporins"/>
            <pathway-xref db="Reactome" id="R-CEL-390696" name="Adrenoceptors"/>
            <pathway-xref db="Reactome" id="R-MMU-419408" name="Lysosphingolipid and LPA receptors"/>
            <pathway-xref db="Reactome" id="R-BTA-428930" name="Thromboxane signalling through TP receptor"/>
            <pathway-xref db="Reactome" id="R-RNO-390696" name="Adrenoceptors"/>
            <pathway-xref db="Reactome" id="R-RNO-9706019" name="RHOBTB3 ATPase cycle"/>
            <pathway-xref db="Reactome" id="R-DME-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-CEL-390651" name="Dopamine receptors"/>
            <pathway-xref db="Reactome" id="R-HSA-444209" name="Free fatty acid receptors"/>
            <pathway-xref db="Reactome" id="R-CFA-390666" name="Serotonin receptors"/>
            <pathway-xref db="Reactome" id="R-RNO-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-CEL-390650" name="Histamine receptors"/>
            <pathway-xref db="Reactome" id="R-MMU-4641263" name="Regulation of FZD by ubiquitination"/>
            <pathway-xref db="Reactome" id="R-BTA-375281" name="Hormone ligand-binding receptors"/>
            <pathway-xref db="Reactome" id="R-DRE-416476" name="G alpha (q) signalling events"/>
            <pathway-xref db="Reactome" id="R-CFA-391908" name="Prostanoid ligand receptors"/>
            <pathway-xref db="Reactome" id="R-DME-9706019" name="RHOBTB3 ATPase cycle"/>
            <pathway-xref db="Reactome" id="R-CEL-416476" name="G alpha (q) signalling events"/>
            <pathway-xref db="Reactome" id="R-HSA-391908" name="Prostanoid ligand receptors"/>
            <pathway-xref db="Reactome" id="R-DRE-375280" name="Amine ligand-binding receptors"/>
            <pathway-xref db="MetaCyc" id="PWY-7856" name="heme a biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SSC-8856828" name="Clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-HSA-6785807" name="Interleukin-4 and Interleukin-13 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-399997" name="Acetylcholine regulates insulin secretion"/>
            <pathway-xref db="Reactome" id="R-HSA-373076" name="Class A/1 (Rhodopsin-like receptors)"/>
            <pathway-xref db="Reactome" id="R-MMU-418555" name="G alpha (s) signalling events"/>
            <pathway-xref db="Reactome" id="R-RNO-419771" name="Opsins"/>
            <pathway-xref db="Reactome" id="R-GGA-416476" name="G alpha (q) signalling events"/>
            <pathway-xref db="Reactome" id="R-CEL-8856828" name="Clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-DRE-977606" name="Regulation of Complement cascade"/>
            <pathway-xref db="Reactome" id="R-MMU-418592" name="ADP signalling through P2Y purinoceptor 1"/>
          </entry>
          <signature-library-release library="PROSITE_PROFILES" version="2021_01"/>
        </signature>
        <model-ac>PS50262</model-ac>
        <locations>
          <profilescan-location score="30.60244" start="11" end="274">
            <location-fragments>
              <profilescan-location-fragment start="11" end="274" dc-status="CONTINUOUS"/>
            </location-fragments>
            <alignment>ESYRHLFYIYRAKSLRTPSNLFVVNLAFCDFIMMLKA-PIFIYNSFNTGFATGHLGCQIFACMGALSGIGAGMTNAAIAYDRYSTIARPLDGK--LSRGQVMLLIVLIWTYTIPWALMPLMHVWGRFVPEGFLTSCTFDYLT-DTPEIRYFVATIFTFSYCIPMSFIIYYYSQIVSHVVNHEKALREQakkmnveslrsnANTNAQSAEIRIAKAAITICFLFVLSWTPYGTLAMIGAF---GNKALLTPGVTMIPACTCKFVACLDPYVY</alignment>
          </profilescan-location>
        </locations>
      </profilescan-match>
      <rpsblast-match>
        <signature ac="cd15079" desc="7tmA_photoreceptors_insect" name="7tmA_photoreceptors_insect">
          <signature-library-release library="CDD" version="3.18"/>
        </signature>
        <model-ac>cd15079</model-ac>
        <locations>
          <rpsblast-location evalue="4.39035E-166" score="461.661" start="18" end="285">
            <location-fragments>
              <rpsblast-location-fragment start="18" end="285" dc-status="CONTINUOUS"/>
            </location-fragments>
            <sites>
              <rpsblast-site description="putative ligand binding site" numLocations="16">
                <site-locations>
                  <site-location residue="W" start="233" end="233"/>
                  <site-location residue="S" start="142" end="142"/>
                  <site-location residue="K" start="264" end="264"/>
                  <site-location residue="F" start="162" end="162"/>
                  <site-location residue="C" start="143" end="143"/>
                  <site-location residue="A" start="260" end="260"/>
                  <site-location residue="I" start="161" end="161"/>
                  <site-location residue="A" start="74" end="74"/>
                  <site-location residue="T" start="144" end="144"/>
                  <site-location residue="F" start="145" end="145"/>
                  <site-location residue="G" start="73" end="73"/>
                  <site-location residue="F" start="69" end="69"/>
                  <site-location residue="G" start="77" end="77"/>
                  <site-location residue="G" start="237" end="237"/>
                  <site-location residue="Y" start="166" end="166"/>
                  <site-location residue="I" start="78" end="78"/>
                </site-locations>
              </rpsblast-site>
            </sites>
          </rpsblast-location>
        </locations>
      </rpsblast-match>
      <superfamilyhmmer3-match evalue="1.19E-53">
        <signature ac="SSF81321" name="Family A G protein-coupled receptor-like">
          <signature-library-release library="SUPERFAMILY" version="1.75"/>
        </signature>
        <model-ac>0037432</model-ac>
        <locations>
          <superfamilyhmmer3-location hmm-length="348" start="15" end="306">
            <location-fragments>
              <superfamilyhmmer3-location-fragment start="15" end="306" dc-status="CONTINUOUS"/>
            </location-fragments>
          </superfamilyhmmer3-location>
        </locations>
      </superfamilyhmmer3-match>
    </matches>
  </protein>
  <protein>
    <sequence md5="5cbdfe40637fafa097d20c7e3cfcd27f">MVFNSGWSPVRNESQSSANIYKRRKLTMLKTIKILCVLLKVFMLMRTALTSSSKDQEDCTTQDNPSFRFIDVHEYVSSNIESVQYYFENDTMRKRNEVGETTPSSGSIPSEPTFPRAFVEFNDRLNQKDIFVTFRWNEPKFTNGVIQKYTVQYWFFENQIIHRTVVIISNFTILQHKVYNLKPDRVYYFEVQAHNKFGAGSYTKFINVSTTYENPVPLLLVKEKDKVYVLDKDLQIGFERDIYIYCTEYVYSALEHKIYGITYKSELITLQFNPNAIETNQNYTIIAEIRYNAYSLCIDWIGGSLYWLEETIDHIYIMKLDLILLQQKGIKTYEKIALAAKHTLFLRALPYNRHLYWIEDSSIVQTDFNGRNKLYMANNKCFCLKTFLGLLQYEYTLMTIDTTNIDEPLIYWIINNEYLIVTDINGCNCNMILKFPNQSIYRFDDIVIDSINIYLISYGYYEIYILRKGNALHQSKKNLFECLKKIHFEDGFFDFIALDKTLQSYPPKKCLISTKNYRVEEMLITANSIKVNLPEPNPNDECKKYNFTFIYNISVSYLKCLDNNLDKFEEFYVQTYERQYEFQNLTQLTEYTLKLALSNFYVHKLSMDLQFGPDVKLITTGKLYAPDDVVVQVVMPNLAIIDWMPPKKLGCVAVNYEVKWMQYSNSTQENQNLFRFIKAYKLERTTNGKFFAVIPSLVPKQKYEIYVSVYSIIRTDVVTDSVIKTIYISEPNNLSLNEVGTKSMNISWIPSVNLTIPIEFLILEYKNVASRKWRWTFANYIEVNNYKITYYVENLLPKTLYKFRLKLKYTEYREDFIWPSDGEEFIFETLGDARKISSATGTAMQYYLPLILCLIVIIVIYNVYYFYCTYRQRKRSNKIVSPPIMMNTELVPLNEIPFGYTQLNLLNPPRLQYNSDEFALTIIEKNQIIQTKFLGSGAFGSVYQGIIKDFEGLDTTPVAIKMLKRQASSKEKKEFLKEAKLMSHFRHKNVLRILGICLDTNSPLLILELIEPGDLLNYLRNNGTLQSSDSCALRLKDLLAMCEDVARGCCYLERQQFVHKDLACRNCLISVRNHENRIVKIGDFGLARDIYKDHYYRMKGDHPLPVRWMAPESLMFGIFTSQSDVWAFGVLMWEIMSLGEHPYPGKNYSEVIEYVREGGKLPKPLNCPPMLYQLMLHCWKSVIGRPNFTNCVKNIKTLRNNVEDSILVISSLDIFGHRETNHS</sequence>
    <xref id="XP_029176967.1" name="XP_029176967.1 proto-oncogene tyrosine-protein kinase ROS-like isoform X2 [Nylanderia fulva]"/>
    <matches>
      <fingerprints-match evalue="1.2E-27" graphscan="IIIII">
        <signature ac="PR00109" desc="Tyrosine kinase catalytic domain signature" name="TYRKINASE">
          <entry ac="IPR001245" desc="Serine-threonine/tyrosine-protein kinase, catalytic domain" name="Ser-Thr/Tyr_kinase_cat_dom" type="DOMAIN">
            <go-xref category="MOLECULAR_FUNCTION" db="GO" id="GO:0004672" name="protein kinase activity"/>
            <go-xref category="BIOLOGICAL_PROCESS" db="GO" id="GO:0006468" name="protein phosphorylation"/>
            <pathway-xref db="Reactome" id="R-SSC-389357" name="CD28 dependent PI3K/Akt signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-2173791" name="TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)"/>
            <pathway-xref db="Reactome" id="R-HSA-74749" name="Signal attenuation"/>
            <pathway-xref db="Reactome" id="R-DRE-418885" name="DCC mediated attractive signaling"/>
            <pathway-xref db="Reactome" id="R-BTA-389356" name="CD28 co-stimulation"/>
            <pathway-xref db="Reactome" id="R-HSA-202733" name="Cell surface interactions at the vascular wall"/>
            <pathway-xref db="Reactome" id="R-DME-399954" name="Sema3A PAK dependent Axon repulsion"/>
            <pathway-xref db="Reactome" id="R-DME-110478" name="Insulin signaling pathway"/>
            <pathway-xref db="Reactome" id="R-HSA-8983432" name="Interleukin-15 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-5673001" name="RAF/MAP kinase cascade"/>
            <pathway-xref db="Reactome" id="R-DME-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-GGA-3928665" name="EPH-ephrin mediated repulsion of cells"/>
            <pathway-xref db="Reactome" id="R-MMU-8983432" name="Interleukin-15 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9013507" name="NOTCH3 Activation and Transmission of Signal to the Nucleus"/>
            <pathway-xref db="Reactome" id="R-HSA-187042" name="TRKA activation by NGF"/>
            <pathway-xref db="Reactome" id="R-MMU-190377" name="FGFR2b ligand binding and activation"/>
            <pathway-xref db="Reactome" id="R-DRE-372708" name="p130Cas linkage to MAPK signaling for integrins"/>
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            <pathway-xref db="Reactome" id="R-HSA-3928664" name="Ephrin signaling"/>
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            <pathway-xref db="Reactome" id="R-DME-209228" name="Formation of the activated STAT92E dimer and transport to the nucleus"/>
            <pathway-xref db="Reactome" id="R-HSA-3928662" name="EPHB-mediated forward signaling"/>
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            <pathway-xref db="Reactome" id="R-HSA-5621480" name="Dectin-2 family"/>
            <pathway-xref db="Reactome" id="R-DRE-190375" name="FGFR2c ligand binding and activation"/>
            <pathway-xref db="Reactome" id="R-HSA-6785807" name="Interleukin-4 and Interleukin-13 signaling"/>
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            <pathway-xref db="Reactome" id="R-CEL-8856828" name="Clathrin-mediated endocytosis"/>
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            <pathway-xref db="Reactome" id="R-DRE-8854691" name="Interleukin-20 family signaling"/>
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            <pathway-xref db="Reactome" id="R-MMU-1059683" name="Interleukin-6 signaling"/>
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            <pathway-xref db="Reactome" id="R-RNO-2672351" name="Stimuli-sensing channels"/>
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            <pathway-xref db="Reactome" id="R-RNO-437239" name="Recycling pathway of L1"/>
            <pathway-xref db="Reactome" id="R-HSA-5654733" name="Negative regulation of FGFR4 signaling"/>
            <pathway-xref db="Reactome" id="R-DME-9027276" name="Erythropoietin activates Phosphoinositide-3-kinase (PI3K)"/>
            <pathway-xref db="Reactome" id="R-DME-9020558" name="Interleukin-2 signaling"/>
            <pathway-xref db="Reactome" id="R-DME-5689896" name="Ovarian tumor domain proteases"/>
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            <pathway-xref db="Reactome" id="R-HSA-2672351" name="Stimuli-sensing channels"/>
            <pathway-xref db="Reactome" id="R-MMU-9027276" name="Erythropoietin activates Phosphoinositide-3-kinase (PI3K)"/>
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            <pathway-xref db="Reactome" id="R-RNO-9013148" name="CDC42 GTPase cycle"/>
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            <pathway-xref db="Reactome" id="R-RNO-9706369" name="Negative regulation of FLT3"/>
            <pathway-xref db="Reactome" id="R-HSA-389359" name="CD28 dependent Vav1 pathway"/>
            <pathway-xref db="Reactome" id="R-RNO-8875791" name="MET activates STAT3"/>
            <pathway-xref db="Reactome" id="R-HSA-9013420" name="RHOU GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-190371" name="FGFR3b ligand binding and activation"/>
            <pathway-xref db="Reactome" id="R-HSA-449836" name="Other interleukin signaling"/>
            <pathway-xref db="Reactome" id="R-DME-9018519" name="Estrogen-dependent gene expression"/>
            <pathway-xref db="Reactome" id="R-HSA-2029485" name="Role of phospholipids in phagocytosis"/>
            <pathway-xref db="Reactome" id="R-DME-5654687" name="Downstream signaling of activated FGFR1"/>
            <pathway-xref db="Reactome" id="R-HSA-3928663" name="EPHA-mediated growth cone collapse"/>
            <pathway-xref db="Reactome" id="R-RNO-8874081" name="MET activates PTK2 signaling"/>
            <pathway-xref db="Reactome" id="R-DRE-5654699" name="SHC-mediated cascade:FGFR2"/>
            <pathway-xref db="Reactome" id="R-CEL-446353" name="Cell-extracellular matrix interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-1839120" name="Signaling by FGFR1 amplification mutants"/>
            <pathway-xref db="Reactome" id="R-HSA-9025046" name="NTF3 activates NTRK2 (TRKB) signaling"/>
            <pathway-xref db="Reactome" id="R-DRE-190374" name="FGFR1c and Klotho ligand binding and activation"/>
            <pathway-xref db="Reactome" id="R-HSA-446388" name="Regulation of cytoskeletal remodeling and cell spreading by IPP complex components"/>
            <pathway-xref db="Reactome" id="R-MMU-9603381" name="Activated NTRK3 signals through PI3K"/>
            <pathway-xref db="Reactome" id="R-RNO-195399" name="VEGF binds to VEGFR leading to receptor dimerization"/>
            <pathway-xref db="Reactome" id="R-DRE-3928664" name="Ephrin signaling"/>
            <pathway-xref db="Reactome" id="R-CEL-9013424" name="RHOV GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-389357" name="CD28 dependent PI3K/Akt signaling"/>
            <pathway-xref db="Reactome" id="R-DME-354192" name="Integrin signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-2730905" name="Role of LAT2/NTAL/LAB on calcium mobilization"/>
            <pathway-xref db="Reactome" id="R-MMU-9013423" name="RAC3 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-9020702" name="Interleukin-1 signaling"/>
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            <pathway-xref db="Reactome" id="R-DRE-5654693" name="FRS-mediated FGFR1 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-9013420" name="RHOU GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-9013149" name="RAC1 GTPase cycle"/>
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            <pathway-xref db="Reactome" id="R-HSA-5689896" name="Ovarian tumor domain proteases"/>
            <pathway-xref db="Reactome" id="R-HSA-2033519" name="Activated point mutants of FGFR2"/>
            <pathway-xref db="Reactome" id="R-RNO-5621480" name="Dectin-2 family"/>
            <pathway-xref db="Reactome" id="R-DME-373753" name="Nephrin family interactions"/>
            <pathway-xref db="Reactome" id="R-GGA-2454202" name="Fc epsilon receptor (FCERI) signaling"/>
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            <pathway-xref db="Reactome" id="R-HSA-9702998" name="linifanib-resistant FLT3 mutants"/>
            <pathway-xref db="Reactome" id="R-HSA-9674401" name="Sunitinib-resistant PDGFR mutants"/>
            <pathway-xref db="Reactome" id="R-DDI-9013404" name="RAC2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-9674428" name="PDGFR mutants bind TKIs"/>
          </entry>
          <signature-library-release library="PRINTS" version="42.0"/>
        </signature>
        <model-ac>PR00109</model-ac>
        <locations>
          <fingerprints-location motifNumber="1" pvalue="6.21E-5" score="42.86" start="1007" end="1020">
            <location-fragments>
              <fingerprints-location-fragment start="1007" end="1020" dc-status="CONTINUOUS"/>
            </location-fragments>
          </fingerprints-location>
          <fingerprints-location motifNumber="2" pvalue="1.17E-9" score="53.84" start="1051" end="1069">
            <location-fragments>
              <fingerprints-location-fragment start="1051" end="1069" dc-status="CONTINUOUS"/>
            </location-fragments>
          </fingerprints-location>
          <fingerprints-location motifNumber="4" pvalue="1.21E-12" score="62.75" start="1123" end="1145">
            <location-fragments>
              <fingerprints-location-fragment start="1123" end="1145" dc-status="CONTINUOUS"/>
            </location-fragments>
          </fingerprints-location>
          <fingerprints-location motifNumber="3" pvalue="3.83E-5" score="63.14" start="1104" end="1114">
            <location-fragments>
              <fingerprints-location-fragment start="1104" end="1114" dc-status="CONTINUOUS"/>
            </location-fragments>
          </fingerprints-location>
          <fingerprints-location motifNumber="5" pvalue="3.86E-4" score="32.32" start="1167" end="1189">
            <location-fragments>
              <fingerprints-location-fragment start="1167" end="1189" dc-status="CONTINUOUS"/>
            </location-fragments>
          </fingerprints-location>
        </locations>
      </fingerprints-match>
      <hmmer2-match evalue="3.1E-14" score="63.3">
        <signature ac="SM00060" name="FN3_2">
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            <pathway-xref db="MetaCyc" id="PWY-6148" name="tetrahydromethanopterin biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-HSA-373752" name="Netrin-1 signaling"/>
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            <pathway-xref db="Reactome" id="R-MMU-1474244" name="Extracellular matrix organization"/>
            <pathway-xref db="Reactome" id="R-MMU-5683826" name="Surfactant metabolism"/>
            <pathway-xref db="Reactome" id="R-RNO-982772" name="Growth hormone receptor signaling"/>
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            <pathway-xref db="MetaCyc" id="PWY-6366" name="D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-MMU-74752" name="Signaling by Insulin receptor"/>
            <pathway-xref db="Reactome" id="R-CEL-9013406" name="RHOQ GTPase cycle"/>
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            <pathway-xref db="Reactome" id="R-HSA-982772" name="Growth hormone receptor signaling"/>
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            <pathway-xref db="Reactome" id="R-MMU-114608" name="Platelet degranulation"/>
            <pathway-xref db="Reactome" id="R-HSA-9027283" name="Erythropoietin activates STAT5"/>
            <pathway-xref db="Reactome" id="R-MMU-196108" name="Pregnenolone biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-MMU-1650814" name="Collagen biosynthesis and modifying enzymes"/>
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            <pathway-xref db="Reactome" id="R-MMU-445355" name="Smooth Muscle Contraction"/>
            <pathway-xref db="Reactome" id="R-HSA-114608" name="Platelet degranulation"/>
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            <pathway-xref db="Reactome" id="R-RNO-9020558" name="Interleukin-2 signaling"/>
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            <pathway-xref db="Reactome" id="R-RNO-5674135" name="MAP2K and MAPK activation"/>
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            <pathway-xref db="Reactome" id="R-CEL-77387" name="Insulin receptor recycling"/>
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            <pathway-xref db="MetaCyc" id="PWY-7771" name="butachlor degradation"/>
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            <pathway-xref db="Reactome" id="R-RNO-8983432" name="Interleukin-15 signaling"/>
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            <pathway-xref db="Reactome" id="R-RNO-9020558" name="Interleukin-2 signaling"/>
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            <pathway-xref db="Reactome" id="R-HSA-2122948" name="Activated NOTCH1 Transmits Signal to the Nucleus"/>
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            <pathway-xref db="Reactome" id="R-MMU-1266695" name="Interleukin-7 signaling"/>
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            <pathway-xref db="MetaCyc" id="PWY-8282" name="adenosylcobinamide-GDP salvage from assorted adenosylcobamides"/>
            <pathway-xref db="Reactome" id="R-MMU-428890" name="Role of ABL in ROBO-SLIT signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-6365" name="D-myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-446107" name="Type I hemidesmosome assembly"/>
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            <pathway-xref db="Reactome" id="R-RNO-390522" name="Striated Muscle Contraction"/>
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            <pathway-xref db="Reactome" id="R-HSA-140834" name="Extrinsic Pathway of Fibrin Clot Formation"/>
            <pathway-xref db="Reactome" id="R-RNO-74751" name="Insulin receptor signalling cascade"/>
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            <pathway-xref db="Reactome" id="R-RNO-912526" name="Interleukin receptor SHC signaling"/>
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            <pathway-xref db="Reactome" id="R-RNO-1474244" name="Extracellular matrix organization"/>
            <pathway-xref db="Reactome" id="R-HSA-8849932" name="Synaptic adhesion-like molecules"/>
            <pathway-xref db="MetaCyc" id="PWY-6456" name="serinol biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-RNO-9009391" name="Extra-nuclear estrogen signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-445095" name="Interaction between L1 and Ankyrins"/>
            <pathway-xref db="Reactome" id="R-CFA-9020958" name="Interleukin-21 signaling"/>
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            <pathway-xref db="Reactome" id="R-RNO-418889" name="Caspase activation via Dependence Receptors in the absence of ligand"/>
            <pathway-xref db="MetaCyc" id="PWY-7771" name="butachlor degradation"/>
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            <pathway-xref db="MetaCyc" id="PWY-6724" name="starch degradation II"/>
            <pathway-xref db="Reactome" id="R-DME-525793" name="Myogenesis"/>
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            <pathway-xref db="Reactome" id="R-RNO-8957275" name="Post-translational protein phosphorylation"/>
            <pathway-xref db="Reactome" id="R-MMU-525793" name="Myogenesis"/>
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            <pathway-xref db="Reactome" id="R-RNO-114608" name="Platelet degranulation"/>
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            <pathway-xref db="Reactome" id="R-HSA-5173105" name="O-linked glycosylation"/>
            <pathway-xref db="Reactome" id="R-RNO-8984722" name="Interleukin-35 Signalling"/>
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            <pathway-xref db="Reactome" id="R-RNO-5635838" name="Activation of SMO"/>
            <pathway-xref db="Reactome" id="R-HSA-8856828" name="Clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-HSA-5635838" name="Activation of SMO"/>
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            <pathway-xref db="Reactome" id="R-RNO-1266695" name="Interleukin-7 signaling"/>
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            <pathway-xref db="Reactome" id="R-MMU-210993" name="Tie2 Signaling"/>
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            <pathway-xref db="Reactome" id="R-MMU-9706369" name="Negative regulation of FLT3"/>
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            <pathway-xref db="Reactome" id="R-MMU-8984722" name="Interleukin-35 Signalling"/>
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            <pathway-xref db="Reactome" id="R-HSA-8854691" name="Interleukin-20 family signaling"/>
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            <pathway-xref db="Reactome" id="R-MMU-74751" name="Insulin receptor signalling cascade"/>
            <pathway-xref db="Reactome" id="R-RNO-6798695" name="Neutrophil degranulation"/>
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            <pathway-xref db="Reactome" id="R-CEL-3928663" name="EPHA-mediated growth cone collapse"/>
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            <pathway-xref db="Reactome" id="R-HSA-9696264" name="RND3 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-9696273" name="RND1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-8856828" name="Clathrin-mediated endocytosis"/>
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            <pathway-xref db="Reactome" id="R-MMU-3928663" name="EPHA-mediated growth cone collapse"/>
            <pathway-xref db="Reactome" id="R-RNO-6785807" name="Interleukin-4 and Interleukin-13 signaling"/>
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            <pathway-xref db="Reactome" id="R-MMU-5632681" name="Ligand-receptor interactions"/>
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            <pathway-xref db="Reactome" id="R-CEL-3928664" name="Ephrin signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-7979" name="protein O-mannosylation III (mammals, core M3)"/>
            <pathway-xref db="Reactome" id="R-HSA-446107" name="Type I hemidesmosome assembly"/>
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            <pathway-xref db="Reactome" id="R-MMU-9027284" name="Erythropoietin activates RAS"/>
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            <pathway-xref db="Reactome" id="R-MMU-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-HSA-9013423" name="RAC3 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-CEL-6798695" name="Neutrophil degranulation"/>
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            <pathway-xref db="Reactome" id="R-MMU-264642" name="Acetylcholine Neurotransmitter Release Cycle"/>
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            <pathway-xref db="Reactome" id="R-CEL-9013424" name="RHOV GTPase cycle"/>
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            <pathway-xref db="MetaCyc" id="PWY-7321" name="ecdysteroid metabolism (arthropods)"/>
            <pathway-xref db="Reactome" id="R-RNO-5173105" name="O-linked glycosylation"/>
            <pathway-xref db="Reactome" id="R-MMU-381426" name="Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"/>
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            <pathway-xref db="Reactome" id="R-CEL-418885" name="DCC mediated attractive signaling"/>
            <pathway-xref db="Reactome" id="R-DME-5689603" name="UCH proteinases"/>
            <pathway-xref db="Reactome" id="R-HSA-5632681" name="Ligand-receptor interactions"/>
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            <pathway-xref db="Reactome" id="R-GGA-8854691" name="Interleukin-20 family signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-9013420" name="RHOU GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-9013149" name="RAC1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-196108" name="Pregnenolone biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-HSA-8856828" name="Clathrin-mediated endocytosis"/>
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            <pathway-xref db="MetaCyc" id="PWY-5473" name="hydroxycinnamic acid serotonin amides biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-109704" name="PI3K Cascade"/>
            <pathway-xref db="Reactome" id="R-MMU-210993" name="Tie2 Signaling"/>
            <pathway-xref db="Reactome" id="R-DRE-8849932" name="Synaptic adhesion-like molecules"/>
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            <pathway-xref db="Reactome" id="R-RNO-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="MetaCyc" id="PWY-6784" name="cellulose and hemicellulose degradation (cellulolosome)"/>
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            <pathway-xref db="MetaCyc" id="PWY-8058" name="2-deoxy-D-ribose degradation II"/>
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            <pathway-xref db="MetaCyc" id="PWY-7577" name="ferrichrome biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-416482" name="G alpha (12/13) signalling events"/>
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            <pathway-xref db="Reactome" id="R-DME-209560" name="NF-kB is activated and signals survival"/>
            <pathway-xref db="MetaCyc" id="PWY-7940" name="lauryl-hydroxychlorobactene glucoside biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5672" name="ginsenosides biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7139" name="sesaminol glucoside biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-RNO-2029485" name="Role of phospholipids in phagocytosis"/>
            <pathway-xref db="Reactome" id="R-MMU-3928662" name="EPHB-mediated forward signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-6763" name="salicortin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-388844" name="Receptor-type tyrosine-protein phosphatases"/>
            <pathway-xref db="MetaCyc" id="PWY-5936" name="xyloglucan biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-8210" name="pyrrolomycin biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-MMU-5654700" name="FRS-mediated FGFR2 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-5292" name="vindoline, vindorosine and vinblastine biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-RNO-9020702" name="Interleukin-1 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-1169408" name="ISG15 antiviral mechanism"/>
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            <pathway-xref db="Reactome" id="R-GGA-8854691" name="Interleukin-20 family signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-2022923" name="Dermatan sulfate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SPO-380972" name="Energy dependent regulation of mTOR by LKB1-AMPK"/>
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            <pathway-xref db="Reactome" id="R-RNO-5632681" name="Ligand-receptor interactions"/>
            <pathway-xref db="MetaCyc" id="PWY-7907" name="(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DRE-190375" name="FGFR2c ligand binding and activation"/>
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            <pathway-xref db="MetaCyc" id="PWY-7140" name="myricetin gentiobioside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-181430" name="Norepinephrine Neurotransmitter Release Cycle"/>
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            <pathway-xref db="Reactome" id="R-RNO-2022854" name="Keratan sulfate biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-RNO-74713" name="IRS activation"/>
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            <pathway-xref db="Reactome" id="R-CEL-913709" name="O-linked glycosylation of mucins"/>
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            <pathway-xref db="Reactome" id="R-RNO-373753" name="Nephrin family interactions"/>
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            <pathway-xref db="Reactome" id="R-HSA-9669924" name="Masitinib-resistant KIT mutants"/>
            <pathway-xref db="MetaCyc" id="PWY-6525" name="stellariose and mediose biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9013404" name="RAC2 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-8241" name="Escherichia coli serotype O:71/Salmonella enterica serotype O:28ac O antigen biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-BTA-1236977" name="Endosomal/Vacuolar pathway"/>
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            <pathway-xref db="MetaCyc" id="PWY-5821" name="dalcochinin biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-6471" name="peptidoglycan biosynthesis IV (Enterococcus faecium)"/>
            <pathway-xref db="Reactome" id="R-DRE-5654726" name="Negative regulation of FGFR1 signaling"/>
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            <pathway-xref db="Reactome" id="R-MMU-9020958" name="Interleukin-21 signaling"/>
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            <pathway-xref db="MetaCyc" id="PWY-7143" name="kaempferol gentiobioside biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-RNO-5687128" name="MAPK6/MAPK4 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-6312" name="barbaloin biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-7468" name="benzoyl-beta-D-glucopyranose biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-6717" name="(1,4)-beta-D-xylan degradation"/>
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            <pathway-xref db="Reactome" id="R-HSA-70268" name="Pyruvate metabolism"/>
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            <pathway-xref db="MetaCyc" id="PWY-5284" name="shisonin biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-7859" name="jasmonoyl-L-isoleucine inactivation"/>
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            <pathway-xref db="MetaCyc" id="PWY-6922" name="L-Ndelta-acetylornithine biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-RNO-2132295" name="MHC class II antigen presentation"/>
            <pathway-xref db="Reactome" id="R-HSA-77387" name="Insulin receptor recycling"/>
            <pathway-xref db="Reactome" id="R-MMU-2428928" name="IRS-related events triggered by IGF1R"/>
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            <pathway-xref db="Reactome" id="R-DRE-2682334" name="EPH-Ephrin signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9020933" name="Interleukin-23 signaling"/>
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            <pathway-xref db="Reactome" id="R-DME-77387" name="Insulin receptor recycling"/>
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            <pathway-xref db="MetaCyc" id="PWY-7599" name="anditomin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-2730905" name="Role of LAT2/NTAL/LAB on calcium mobilization"/>
            <pathway-xref db="MetaCyc" id="PWY-7401" name="crotonate fermentation (to acetate and cyclohexane carboxylate)"/>
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            <pathway-xref db="MetaCyc" id="PWY-5774" name="saponin biosynthesis IV"/>
            <pathway-xref db="Reactome" id="R-DME-5654688" name="SHC-mediated cascade:FGFR1"/>
            <pathway-xref db="Reactome" id="R-HSA-8875513" name="MET interacts with TNS proteins"/>
            <pathway-xref db="Reactome" id="R-CEL-9013420" name="RHOU GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-190322" name="FGFR4 ligand binding and activation"/>
            <pathway-xref db="Reactome" id="R-GGA-5658623" name="FGFRL1 modulation of FGFR1 signaling"/>
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            <pathway-xref db="Reactome" id="R-DME-214844" name="DL and DIF homodimers complexed with CACT are all phosphorylated in the TL receptor 'signalling complex'"/>
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            <pathway-xref db="MetaCyc" id="PWY-5822" name="trichloroethene degradation"/>
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            <pathway-xref db="Reactome" id="R-RNO-216083" name="Integrin cell surface interactions"/>
            <pathway-xref db="Reactome" id="R-RNO-445144" name="Signal transduction by L1"/>
            <pathway-xref db="MetaCyc" id="PWY-2902" name="cytokinin-O-glucosides biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8000" name="vitamin K degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-8036" name="chaxamycin biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-MMU-9013026" name="RHOB GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-1169091" name="Activation of NF-kappaB in B cells"/>
            <pathway-xref db="Reactome" id="R-HSA-2022928" name="HS-GAG biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-RNO-5654219" name="Phospholipase C-mediated cascade: FGFR1"/>
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            <pathway-xref db="MetaCyc" id="PWY-7982" name="pinoresinol degradation"/>
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            <pathway-xref db="Reactome" id="R-DME-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-SSC-202424" name="Downstream TCR signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-198745" name="Signalling to STAT3"/>
            <pathway-xref db="MetaCyc" id="PWY-83" name="monolignol glucosides biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-8853383" name="Lysosomal oligosaccharide catabolism"/>
            <pathway-xref db="Reactome" id="R-MMU-380972" name="Energy dependent regulation of mTOR by LKB1-AMPK"/>
            <pathway-xref db="MetaCyc" id="PWY-7719" name="CMP-diacetamido-8-epilegionaminic acid biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5380" name="A series fagopyritols biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-HSA-430116" name="GP1b-IX-V activation signalling"/>
            <pathway-xref db="Reactome" id="R-CFA-3134963" name="DEx/H-box helicases activate type I IFN and inflammatory cytokines production"/>
            <pathway-xref db="Reactome" id="R-MMU-1266695" name="Interleukin-7 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9702624" name="sorafenib-resistant FLT3 mutants"/>
            <pathway-xref db="Reactome" id="R-HSA-1660661" name="Sphingolipid de novo biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-HSA-9705462" name="Inactivation of CSF3 (G-CSF) signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-210991" name="Basigin interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-8852405" name="Signaling by MST1"/>
            <pathway-xref db="Reactome" id="R-MMU-2024096" name="HS-GAG degradation"/>
            <pathway-xref db="Reactome" id="R-DRE-186797" name="Signaling by PDGF"/>
            <pathway-xref db="Reactome" id="R-RNO-6804756" name="Regulation of TP53 Activity through Phosphorylation"/>
            <pathway-xref db="Reactome" id="R-HSA-5654719" name="SHC-mediated cascade:FGFR4"/>
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            <pathway-xref db="Reactome" id="R-HSA-9013026" name="RHOB GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-2559582" name="Senescence-Associated Secretory Phenotype (SASP)"/>
            <pathway-xref db="Reactome" id="R-DME-9009391" name="Extra-nuclear estrogen signaling"/>
            <pathway-xref db="Reactome" id="R-DME-375165" name="NCAM signaling for neurite out-growth"/>
            <pathway-xref db="MetaCyc" id="PWY-7740" name="beta-D-mannosyl phosphomycoketide biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-2160916" name="Hyaluronan uptake and degradation"/>
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            <pathway-xref db="Reactome" id="R-RNO-445095" name="Interaction between L1 and Ankyrins"/>
            <pathway-xref db="Reactome" id="R-HSA-1442490" name="Collagen degradation"/>
            <pathway-xref db="Reactome" id="R-RNO-418889" name="Caspase activation via Dependence Receptors in the absence of ligand"/>
            <pathway-xref db="Reactome" id="R-HSA-182218" name="Nef Mediated CD8 Down-regulation"/>
            <pathway-xref db="MetaCyc" id="PWY-8152" name="androstenedione degradation II (anaerobic)"/>
            <pathway-xref db="MetaCyc" id="PWY-361" name="phenylpropanoid biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-HSA-9664565" name="Signaling by ERBB2 KD Mutants"/>
            <pathway-xref db="Reactome" id="R-RNO-5654689" name="PI-3K cascade:FGFR1"/>
            <pathway-xref db="Reactome" id="R-DRE-5654689" name="PI-3K cascade:FGFR1"/>
            <pathway-xref db="Reactome" id="R-RNO-8957275" name="Post-translational protein phosphorylation"/>
            <pathway-xref db="Reactome" id="R-MMU-525793" name="Myogenesis"/>
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            <pathway-xref db="Reactome" id="R-HSA-2424491" name="DAP12 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-4086398" name="Ca2+ pathway"/>
            <pathway-xref db="MetaCyc" id="PWY-7921" name="protein O-mannosylation I (yeast)"/>
            <pathway-xref db="MetaCyc" id="PWY-7530" name="Escherichia coli serotype O:104 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-5140745" name="WNT5A-dependent internalization of FZD2, FZD5 and ROR2"/>
            <pathway-xref db="Reactome" id="R-DRE-190322" name="FGFR4 ligand binding and activation"/>
            <pathway-xref db="MetaCyc" id="PWY-7463" name="N-methylanthraniloyl-beta-D-glucopyranose biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-975634" name="Retinoid metabolism and transport"/>
            <pathway-xref db="MetaCyc" id="PWY-7166" name="kaempferide triglycoside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-8865999" name="MET activates PTPN11"/>
            <pathway-xref db="Reactome" id="R-HSA-9664323" name="FCGR3A-mediated IL10 synthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-5635838" name="Activation of SMO"/>
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            <pathway-xref db="Reactome" id="R-HSA-1300645" name="Acrosome Reaction and Sperm:Oocyte Membrane Binding"/>
            <pathway-xref db="Reactome" id="R-RNO-2022870" name="Chondroitin sulfate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-6809371" name="Formation of the cornified envelope"/>
            <pathway-xref db="Reactome" id="R-MMU-5660668" name="CLEC7A/inflammasome pathway"/>
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            <pathway-xref db="Reactome" id="R-HSA-5684264" name="MAP3K8 (TPL2)-dependent MAPK1/3 activation"/>
            <pathway-xref db="Reactome" id="R-DRE-190372" name="FGFR3c ligand binding and activation"/>
            <pathway-xref db="MetaCyc" id="PWY-7706" name="dapdiamides biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-MMU-5654227" name="Phospholipase C-mediated cascade, FGFR3"/>
            <pathway-xref db="Reactome" id="R-MMU-9696273" name="RND1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-110056" name="MAPK3 (ERK1) activation"/>
            <pathway-xref db="Reactome" id="R-MMU-372708" name="p130Cas linkage to MAPK signaling for integrins"/>
            <pathway-xref db="MetaCyc" id="PWY-1981" name="indole-3-acetate inactivation III"/>
            <pathway-xref db="Reactome" id="R-DRE-5654700" name="FRS-mediated FGFR2 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-6785807" name="Interleukin-4 and Interleukin-13 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-8964046" name="VLDL clearance"/>
            <pathway-xref db="MetaCyc" id="PWY-7979" name="protein O-mannosylation III (mammals, core M3)"/>
            <pathway-xref db="Reactome" id="R-HSA-9013423" name="RAC3 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-6310" name="aloesone biosynthesis II"/>
            <pathway-xref db="Reactome" id="R-HSA-389359" name="CD28 dependent Vav1 pathway"/>
            <pathway-xref db="MetaCyc" id="PWY-7191" name="kaempferol diglycoside biosynthesis (pollen-specific)"/>
            <pathway-xref db="Reactome" id="R-HSA-9013420" name="RHOU GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-7815" name="poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)"/>
            <pathway-xref db="Reactome" id="R-HSA-212676" name="Dopamine Neurotransmitter Release Cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-842" name="starch degradation I"/>
            <pathway-xref db="Reactome" id="R-RNO-416476" name="G alpha (q) signalling events"/>
            <pathway-xref db="Reactome" id="R-RNO-8874081" name="MET activates PTK2 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-7129" name="quercetin glucoside biosynthesis (Allium)"/>
            <pathway-xref db="Reactome" id="R-HSA-9020702" name="Interleukin-1 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9013508" name="NOTCH3 Intracellular Domain Regulates Transcription"/>
            <pathway-xref db="Reactome" id="R-MMU-193634" name="Axonal growth inhibition (RHOA activation)"/>
            <pathway-xref db="Reactome" id="R-MMU-1462054" name="Alpha-defensins"/>
            <pathway-xref db="Reactome" id="R-BTA-388841" name="Costimulation by the CD28 family"/>
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            <pathway-xref db="MetaCyc" id="PWY-5466" name="matairesinol biosynthesis"/>
            <pathway-xref db="Reactome" id="R-GGA-373920" name="Pyruvate metabolism"/>
            <pathway-xref db="Reactome" id="R-DME-110478" name="Insulin signaling pathway"/>
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            <pathway-xref db="MetaCyc" id="PWY-7382" name="lipoate biosynthesis and incorporation IV (yeast)"/>
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            <pathway-xref db="Reactome" id="R-MMU-190377" name="FGFR2b ligand binding and activation"/>
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            <pathway-xref db="MetaCyc" id="PWY-7460" name="2-O-acetyl-3-O-trans-coutarate biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-HSA-9669934" name="Sunitinib-resistant KIT mutants"/>
            <pathway-xref db="Reactome" id="R-MMU-418990" name="Adherens junctions interactions"/>
            <pathway-xref db="Reactome" id="R-CEL-416572" name="Sema4D induced cell migration and growth-cone collapse"/>
            <pathway-xref db="Reactome" id="R-RNO-9014826" name="Interleukin-36 pathway"/>
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            <pathway-xref db="Reactome" id="R-HSA-3656225" name="Defective CHST6 causes MCDC1"/>
            <pathway-xref db="Reactome" id="R-GGA-5173105" name="O-linked glycosylation"/>
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            <pathway-xref db="Reactome" id="R-CFA-2024096" name="HS-GAG degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-2871796" name="FCERI mediated MAPK activation"/>
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            <pathway-xref db="Reactome" id="R-MMU-2022870" name="Chondroitin sulfate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CFA-193692" name="Regulated proteolysis of p75NTR"/>
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            <pathway-xref db="Reactome" id="R-HSA-9674404" name="Sorafenib-resistant PDGFR mutants"/>
            <pathway-xref db="MetaCyc" id="PWY-8219" name="Escherichia coli serotype O:107 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-181429" name="Serotonin Neurotransmitter Release Cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-5397" name="crocetin biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-MMU-9007892" name="Interleukin-38 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-5083629" name="Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2"/>
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            <pathway-xref db="Reactome" id="R-RNO-372708" name="p130Cas linkage to MAPK signaling for integrins"/>
            <pathway-xref db="Reactome" id="R-HSA-5658623" name="FGFRL1 modulation of FGFR1 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-9027276" name="Erythropoietin activates Phosphoinositide-3-kinase (PI3K)"/>
            <pathway-xref db="Reactome" id="R-SSC-1236977" name="Endosomal/Vacuolar pathway"/>
            <pathway-xref db="Reactome" id="R-RNO-373760" name="L1CAM interactions"/>
            <pathway-xref db="MetaCyc" id="PWY-7071" name="steviol glucoside biosynthesis (rebaudioside A biosynthesis)"/>
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            <pathway-xref db="Reactome" id="R-MMU-5654726" name="Negative regulation of FGFR1 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9032500" name="Activated NTRK2 signals through FYN"/>
            <pathway-xref db="Reactome" id="R-DME-5654228" name="Phospholipase C-mediated cascade, FGFR4"/>
            <pathway-xref db="Reactome" id="R-HSA-9674403" name="Regorafenib-resistant PDGFR mutants"/>
            <pathway-xref db="Reactome" id="R-MMU-173736" name="Alternative complement activation"/>
            <pathway-xref db="Reactome" id="R-HSA-202427" name="Phosphorylation of CD3 and TCR zeta chains"/>
            <pathway-xref db="Reactome" id="R-SSC-9013405" name="RHOD GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-8248" name="lipid A-core biosynthesis (P. gingivalis)"/>
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            <pathway-xref db="Reactome" id="R-HSA-5689603" name="UCH proteinases"/>
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            <pathway-xref db="Reactome" id="R-RNO-5576892" name="Phase 0 - rapid depolarisation"/>
            <pathway-xref db="Reactome" id="R-DME-190322" name="FGFR4 ligand binding and activation"/>
            <pathway-xref db="MetaCyc" id="PWY-6558" name="heparan sulfate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-75892" name="Platelet Adhesion to exposed collagen"/>
            <pathway-xref db="MetaCyc" id="PWY-5976" name="dhurrin degradation"/>
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            <pathway-xref db="Reactome" id="R-MMU-173623" name="Classical antibody-mediated complement activation"/>
            <pathway-xref db="MetaCyc" id="PWY-8038" name="naphthomycin biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-RNO-1059683" name="Interleukin-6 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-7672" name="fusaric acid biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-HSA-5654712" name="FRS-mediated FGFR4 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-196108" name="Pregnenolone biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-74752" name="Signaling by Insulin receptor"/>
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            <pathway-xref db="MetaCyc" id="PWY-6362" name="1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)"/>
            <pathway-xref db="Reactome" id="R-MMU-418889" name="Caspase activation via Dependence Receptors in the absence of ligand"/>
            <pathway-xref db="Reactome" id="R-MMU-375276" name="Peptide ligand-binding receptors"/>
            <pathway-xref db="Reactome" id="R-DME-5654700" name="FRS-mediated FGFR2 signaling"/>
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            <pathway-xref db="Reactome" id="R-MMU-9020956" name="Interleukin-27 signaling"/>
            <pathway-xref db="Reactome" id="R-GGA-434131" name="NFkB activation mediated by RIP1 complexed with activated TLR3"/>
            <pathway-xref db="Reactome" id="R-MMU-202430" name="Translocation of ZAP-70 to Immunological synapse"/>
            <pathway-xref db="Reactome" id="R-HSA-9013409" name="RHOJ GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-432142" name="Platelet sensitization by LDL"/>
            <pathway-xref db="Reactome" id="R-HSA-9020956" name="Interleukin-27 signaling"/>
            <pathway-xref db="Reactome" id="R-SSC-2024096" name="HS-GAG degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-8075" name="(Kdo)2-lipid A biosynthesis (P. putida)"/>
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            <pathway-xref db="Reactome" id="R-RNO-879415" name="Advanced glycosylation endproduct receptor signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-210500" name="Glutamate Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-SCE-9609523" name="Insertion of tail-anchored proteins into the endoplasmic reticulum membrane"/>
            <pathway-xref db="Reactome" id="R-GGA-2132286" name="Classical antibody-mediated complement activation"/>
            <pathway-xref db="Reactome" id="R-RNO-418885" name="DCC mediated attractive signaling"/>
            <pathway-xref db="Reactome" id="R-BTA-9013404" name="RAC2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-5654727" name="Negative regulation of FGFR2 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-3322077" name="Glycogen synthesis"/>
            <pathway-xref db="Reactome" id="R-SCE-380972" name="Energy dependent regulation of mTOR by LKB1-AMPK"/>
            <pathway-xref db="MetaCyc" id="PWY-6788" name="cellulose degradation II (fungi)"/>
            <pathway-xref db="Reactome" id="R-RNO-163125" name="Post-translational modification: synthesis of GPI-anchored proteins"/>
            <pathway-xref db="Reactome" id="R-SSC-9013408" name="RHOG GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-6686" name="mannosylglucosylglycerate biosynthesis I"/>
            <pathway-xref db="MetaCyc" id="PWY-8052" name="2-arachidonoylglycerol biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-3000178" name="ECM proteoglycans"/>
            <pathway-xref db="Reactome" id="R-RNO-9034793" name="Activated NTRK3 signals through PLCG1"/>
            <pathway-xref db="Reactome" id="R-RNO-9013404" name="RAC2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-198203" name="PI3K/AKT activation"/>
            <pathway-xref db="Reactome" id="R-HSA-9013406" name="RHOQ GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-5621575" name="CD209 (DC-SIGN) signaling"/>
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            <pathway-xref db="Reactome" id="R-BTA-1660661" name="Sphingolipid de novo biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7818" name="type IV lipoteichoic acid biosynthesis (S. pneumoniae)"/>
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            <pathway-xref db="MetaCyc" id="PWY-6385" name="peptidoglycan biosynthesis III (mycobacteria)"/>
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            <pathway-xref db="MetaCyc" id="PWY-7601" name="arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)"/>
            <pathway-xref db="Reactome" id="R-MMU-2168880" name="Scavenging of heme from plasma"/>
            <pathway-xref db="Reactome" id="R-DME-214842" name="DL and DIF homodimers bind to TUB and phosphorylated PLL in the TL receptor 'signalling complex'"/>
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            <pathway-xref db="MetaCyc" id="PWY-7983" name="pseudomonine biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-MMU-170968" name="Frs2-mediated activation"/>
            <pathway-xref db="Reactome" id="R-MMU-983695" name="Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"/>
            <pathway-xref db="MetaCyc" id="PWY-6322" name="phosphinothricin tripeptide biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-CEL-5218920" name="VEGFR2 mediated vascular permeability"/>
            <pathway-xref db="MetaCyc" id="PWY-5437" name="L-threonine degradation I"/>
            <pathway-xref db="Reactome" id="R-HSA-9034015" name="Signaling by NTRK3 (TRKC)"/>
            <pathway-xref db="Reactome" id="R-RNO-193634" name="Axonal growth inhibition (RHOA activation)"/>
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            <pathway-xref db="Reactome" id="R-RNO-354192" name="Integrin signaling"/>
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            <pathway-xref db="Reactome" id="R-RNO-389359" name="CD28 dependent Vav1 pathway"/>
            <pathway-xref db="MetaCyc" id="PWY-7172" name="flavonol acylglucoside biosynthesis III - quercetin derivatives"/>
            <pathway-xref db="Reactome" id="R-RNO-193648" name="NRAGE signals death through JNK"/>
            <pathway-xref db="MetaCyc" id="PWY-6032" name="digitoxigenin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-1855183" name="Synthesis of IP2, IP, and Ins in the cytosol"/>
            <pathway-xref db="Reactome" id="R-HSA-1855183" name="Synthesis of IP2, IP, and Ins in the cytosol"/>
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            <pathway-xref db="MetaCyc" id="PWY-7192" name="quercetin diglycoside biosynthesis (pollen-specific)"/>
            <pathway-xref db="Reactome" id="R-DME-214411" name="REL binds to DREDD in the PGN:PGRP-LC/LE receptor 'signalling complex'"/>
            <pathway-xref db="MetaCyc" id="PWY-7771" name="butachlor degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-449836" name="Other interleukin signaling"/>
            <pathway-xref db="Reactome" id="R-DME-5658623" name="FGFRL1 modulation of FGFR1 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-6190" name="2,4-dichlorotoluene degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-114604" name="GPVI-mediated activation cascade"/>
            <pathway-xref db="MetaCyc" id="PWY-6623" name="salicylate glucosides biosynthesis II"/>
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            <pathway-xref db="MetaCyc" id="PWY-7045" name="mithramycin biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-BTA-6798695" name="Neutrophil degranulation"/>
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            <pathway-xref db="Reactome" id="R-MMU-216083" name="Integrin cell surface interactions"/>
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            <pathway-xref db="Reactome" id="R-DRE-5654688" name="SHC-mediated cascade:FGFR1"/>
            <pathway-xref db="Reactome" id="R-HSA-3656244" name="Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)"/>
            <pathway-xref db="Reactome" id="R-RNO-5635838" name="Activation of SMO"/>
            <pathway-xref db="Reactome" id="R-RNO-1266695" name="Interleukin-7 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-416572" name="Sema4D induced cell migration and growth-cone collapse"/>
            <pathway-xref db="Reactome" id="R-MMU-204005" name="COPII-mediated vesicle transport"/>
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            <pathway-xref db="Reactome" id="R-MMU-8984722" name="Interleukin-35 Signalling"/>
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            <pathway-xref db="Reactome" id="R-GGA-198933" name="Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"/>
            <pathway-xref db="Reactome" id="R-MMU-432722" name="Golgi Associated Vesicle Biogenesis"/>
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            <pathway-xref db="Reactome" id="R-CEL-3928664" name="Ephrin signaling"/>
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            <pathway-xref db="Reactome" id="R-SSC-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-264642" name="Acetylcholine Neurotransmitter Release Cycle"/>
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            <pathway-xref db="Reactome" id="R-HSA-2586552" name="Signaling by Leptin"/>
            <pathway-xref db="Reactome" id="R-MMU-983170" name="Antigen Presentation: Folding, assembly and peptide loading of class I MHC"/>
            <pathway-xref db="Reactome" id="R-MMU-9028731" name="Activated NTRK2 signals through FRS2 and FRS3"/>
            <pathway-xref db="Reactome" id="R-RNO-186763" name="Downstream signal transduction"/>
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            <pathway-xref db="Reactome" id="R-RNO-5173105" name="O-linked glycosylation"/>
            <pathway-xref db="Reactome" id="R-CFA-1810476" name="RIP-mediated NFkB activation via ZBP1"/>
            <pathway-xref db="Reactome" id="R-MMU-8865999" name="MET activates PTPN11"/>
            <pathway-xref db="MetaCyc" id="PWY-7367" name="phosphatidylcholine resynthesis via glycerophosphocholine"/>
            <pathway-xref db="Reactome" id="R-HSA-196108" name="Pregnenolone biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8039" name="mitomycin biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-CFA-1169091" name="Activation of NF-kappaB in B cells"/>
            <pathway-xref db="MetaCyc" id="PWY-7735" name="echinomycin and triostin A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-8983711" name="OAS antiviral response"/>
            <pathway-xref db="MetaCyc" id="PWY-7621" name="autoinducer CAI-1 biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-166665" name="Terminal pathway of complement"/>
            <pathway-xref db="MetaCyc" id="PWY-8047" name="bryostatin biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-MMU-70268" name="Pyruvate metabolism"/>
            <pathway-xref db="Reactome" id="R-SSC-9013106" name="RHOC GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-419037" name="NCAM1 interactions"/>
            <pathway-xref db="MetaCyc" id="PWY-6948" name="sitosterol degradation to androstenedione"/>
            <pathway-xref db="Reactome" id="R-DME-5654695" name="PI-3K cascade:FGFR2"/>
            <pathway-xref db="Reactome" id="R-CFA-2024101" name="CS/DS degradation"/>
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            <pathway-xref db="Reactome" id="R-SSC-2172127" name="DAP12 interactions"/>
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            <pathway-xref db="Reactome" id="R-DRE-5654719" name="SHC-mediated cascade:FGFR4"/>
            <pathway-xref db="Reactome" id="R-MMU-5654689" name="PI-3K cascade:FGFR1"/>
            <pathway-xref db="Reactome" id="R-RNO-210500" name="Glutamate Neurotransmitter Release Cycle"/>
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            <pathway-xref db="Reactome" id="R-RNO-9014843" name="Interleukin-33 signaling"/>
            <pathway-xref db="Reactome" id="R-CEL-376172" name="DSCAM interactions"/>
            <pathway-xref db="MetaCyc" id="PWY-8251" name="Escherichia coli serotype O:2 O antigen biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-HSA-5607764" name="CLEC7A (Dectin-1) signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-6527" name="stachyose degradation"/>
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            <pathway-xref db="Reactome" id="R-DME-5621575" name="CD209 (DC-SIGN) signaling"/>
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            <pathway-xref db="Reactome" id="R-DME-190377" name="FGFR2b ligand binding and activation"/>
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            <pathway-xref db="MetaCyc" id="PWY-8252" name="Escherichia coli serotype O:50 O antigen biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-6364" name="D-myo-inositol (1,3,4)-trisphosphate biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-RNO-8851805" name="MET activates RAS signaling"/>
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            <pathway-xref db="MetaCyc" id="PWY-8157" name="avenanthramide biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-MMU-416476" name="G alpha (q) signalling events"/>
            <pathway-xref db="MetaCyc" id="PWY-5846" name="colchicine biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-MMU-912694" name="Regulation of IFNA signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-8875656" name="MET receptor recycling"/>
            <pathway-xref db="Reactome" id="R-RNO-446353" name="Cell-extracellular matrix interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-9660826" name="Purinergic signaling in leishmaniasis infection"/>
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            <pathway-xref db="Reactome" id="R-CEL-8853383" name="Lysosomal oligosaccharide catabolism"/>
            <pathway-xref db="Reactome" id="R-HSA-354192" name="Integrin signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-7708" name="lyngbyatoxin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-1236974" name="ER-Phagosome pathway"/>
            <pathway-xref db="MetaCyc" id="PWY-7946" name="sarcinaxanthin diglucoside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-2206302" name="MPS I - Hurler syndrome"/>
            <pathway-xref db="Reactome" id="R-MMU-399954" name="Sema3A PAK dependent Axon repulsion"/>
            <pathway-xref db="Reactome" id="R-DME-5654710" name="PI-3K cascade:FGFR3"/>
            <pathway-xref db="Reactome" id="R-RNO-2172127" name="DAP12 interactions"/>
            <pathway-xref db="MetaCyc" id="PWY-7883" name="anhydromuropeptides recycling II"/>
            <pathway-xref db="Reactome" id="R-RNO-8963896" name="HDL assembly"/>
            <pathway-xref db="Reactome" id="R-DME-5632681" name="Ligand-receptor interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-2129379" name="Molecules associated with elastic fibres"/>
            <pathway-xref db="MetaCyc" id="PWY-7960" name="rhabduscin biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-6658" name="acetan biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-4086400" name="PCP/CE pathway"/>
            <pathway-xref db="Reactome" id="R-CFA-933542" name="TRAF6 mediated NF-kB activation"/>
            <pathway-xref db="MetaCyc" id="PWY-8166" name="emodin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-381426" name="Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"/>
            <pathway-xref db="Reactome" id="R-BTA-1236974" name="ER-Phagosome pathway"/>
            <pathway-xref db="Reactome" id="R-MMU-9013405" name="RHOD GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-5343" name="ajugose biosynthesis II (galactinol-independent)"/>
            <pathway-xref db="Reactome" id="R-HSA-210744" name="Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells"/>
            <pathway-xref db="MetaCyc" id="PWY-7677" name="rosamicin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7261" name="anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)"/>
            <pathway-xref db="Reactome" id="R-DME-416572" name="Sema4D induced cell migration and growth-cone collapse"/>
            <pathway-xref db="Reactome" id="R-CEL-9013404" name="RAC2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-CFA-5607764" name="CLEC7A (Dectin-1) signaling"/>
            <pathway-xref db="Reactome" id="R-DME-264876" name="Insulin processing"/>
            <pathway-xref db="MetaCyc" id="PWY-7702" name="sch210971 and sch210972 biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7253" name="apigeninidin 5-O-glucoside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-977225" name="Amyloid fiber formation"/>
            <pathway-xref db="Reactome" id="R-MMU-5654727" name="Negative regulation of FGFR2 signaling"/>
            <pathway-xref db="Reactome" id="R-XTR-418990" name="Adherens junctions interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-9013148" name="CDC42 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-3322077" name="Glycogen synthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-1474244" name="Extracellular matrix organization"/>
            <pathway-xref db="Reactome" id="R-HSA-433692" name="Proton-coupled monocarboxylate transport"/>
            <pathway-xref db="Reactome" id="R-RNO-982772" name="Growth hormone receptor signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-399956" name="CRMPs in Sema3A signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-74752" name="Signaling by Insulin receptor"/>
            <pathway-xref db="Reactome" id="R-HSA-8985947" name="Interleukin-9 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-6056" name="dimethylsulfoniopropanoate degradation II (cleavage)"/>
            <pathway-xref db="Reactome" id="R-MMU-5658623" name="FGFRL1 modulation of FGFR1 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-7452" name="cyanidin dimalonylglucoside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-5654693" name="FRS-mediated FGFR1 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-200425" name="Carnitine metabolism"/>
            <pathway-xref db="MetaCyc" id="PWY-5176" name="coumarin biosynthesis (via 2-coumarate)"/>
            <pathway-xref db="Reactome" id="R-MMU-9013148" name="CDC42 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-2428933" name="SHC-related events triggered by IGF1R"/>
            <pathway-xref db="MetaCyc" id="PWY-6996" name="daidzin and daidzein degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-5689603" name="UCH proteinases"/>
            <pathway-xref db="Reactome" id="R-HSA-6783783" name="Interleukin-10 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-8985801" name="Regulation of cortical dendrite branching"/>
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            <pathway-xref db="MetaCyc" id="PWY-7456" name="beta-(1,4)-mannan degradation"/>
            <pathway-xref db="Reactome" id="R-DRE-5654687" name="Downstream signaling of activated FGFR1"/>
            <pathway-xref db="MetaCyc" id="PWY-5797" name="indole-3-acetate inactivation VI"/>
            <pathway-xref db="MetaCyc" id="PWY-7246" name="pectin degradation I"/>
            <pathway-xref db="Reactome" id="R-DRE-1307965" name="betaKlotho-mediated ligand binding"/>
            <pathway-xref db="Reactome" id="R-MMU-8875513" name="MET interacts with TNS proteins"/>
            <pathway-xref db="Reactome" id="R-CFA-5621575" name="CD209 (DC-SIGN) signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-5654712" name="FRS-mediated FGFR4 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-5679" name="clavulanate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-416550" name="Sema4D mediated inhibition of cell attachment and migration"/>
            <pathway-xref db="Reactome" id="R-HSA-5688849" name="Defective CSF2RB causes SMDP5"/>
            <pathway-xref db="MetaCyc" id="PWY-7511" name="protein ubiquitination"/>
            <pathway-xref db="Reactome" id="R-HSA-9702600" name="midostaurin-resistant FLT3 mutants"/>
            <pathway-xref db="Reactome" id="R-MMU-2428933" name="SHC-related events triggered by IGF1R"/>
            <pathway-xref db="Reactome" id="R-DME-2871837" name="FCERI mediated NF-kB activation"/>
            <pathway-xref db="Reactome" id="R-MMU-388841" name="Costimulation by the CD28 family"/>
            <pathway-xref db="MetaCyc" id="PWY-5491" name="diethylphosphate degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-166663" name="Initial triggering of complement"/>
            <pathway-xref db="Reactome" id="R-HSA-5218921" name="VEGFR2 mediated cell proliferation"/>
            <pathway-xref db="MetaCyc" id="PWY-6821" name="kappa-carrageenan degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-1961" name="indole-3-acetate inactivation I"/>
            <pathway-xref db="Reactome" id="R-HSA-428890" name="Role of ABL in ROBO-SLIT signaling"/>
            <pathway-xref db="Reactome" id="R-DRE-5654695" name="PI-3K cascade:FGFR2"/>
            <pathway-xref db="Reactome" id="R-HSA-3000170" name="Syndecan interactions"/>
            <pathway-xref db="Reactome" id="R-MMU-8985947" name="Interleukin-9 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-9032759" name="NTRK2 activates RAC1"/>
            <pathway-xref db="Reactome" id="R-HSA-2219530" name="Constitutive Signaling by Aberrant PI3K in Cancer"/>
            <pathway-xref db="Reactome" id="R-HSA-2168880" name="Scavenging of heme from plasma"/>
            <pathway-xref db="MetaCyc" id="PWY-7265" name="lampranthin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-451927" name="Interleukin-2 family signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-1170546" name="Prolactin receptor signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-1170546" name="Prolactin receptor signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-1169408" name="ISG15 antiviral mechanism"/>
            <pathway-xref db="Reactome" id="R-HSA-8939247" name="RUNX1 regulates transcription of genes involved in interleukin signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-7624" name="nystatin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-5621575" name="CD209 (DC-SIGN) signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-6397" name="mycolyl-arabinogalactan-peptidoglycan complex biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-982772" name="Growth hormone receptor signaling"/>
            <pathway-xref db="Reactome" id="R-DRE-202733" name="Cell surface interactions at the vascular wall"/>
            <pathway-xref db="MetaCyc" id="PWY-8249" name="xanthommatin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-8875656" name="MET receptor recycling"/>
            <pathway-xref db="Reactome" id="R-CEL-373756" name="SDK interactions"/>
            <pathway-xref db="Reactome" id="R-RNO-433692" name="Proton-coupled monocarboxylate transport"/>
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            <pathway-xref db="MetaCyc" id="PWY-8212" name="Escherichia coli serotype O:8 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-416700" name="Other semaphorin interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-2428928" name="IRS-related events triggered by IGF1R"/>
            <pathway-xref db="Reactome" id="R-MMU-388844" name="Receptor-type tyrosine-protein phosphatases"/>
            <pathway-xref db="Reactome" id="R-RNO-9020558" name="Interleukin-2 signaling"/>
            <pathway-xref db="Reactome" id="R-SSC-1660661" name="Sphingolipid de novo biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-140834" name="Extrinsic Pathway of Fibrin Clot Formation"/>
            <pathway-xref db="Reactome" id="R-HSA-3000157" name="Laminin interactions"/>
            <pathway-xref db="Reactome" id="R-DME-190371" name="FGFR3b ligand binding and activation"/>
            <pathway-xref db="Reactome" id="R-SSC-2424491" name="DAP12 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-5710" name="capsaicin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-5688890" name="Defective CSF2RA causes SMDP4"/>
            <pathway-xref db="Reactome" id="R-CEL-3928662" name="EPHB-mediated forward signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-202424" name="Downstream TCR signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-7474" name="avenacin A-2 biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8282" name="adenosylcobinamide-GDP salvage from assorted adenosylcobamides"/>
            <pathway-xref db="Reactome" id="R-MMU-8851805" name="MET activates RAS signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-5379" name="B series fagopyritols biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7037" name="protein O-glycosylation (Neisseria)"/>
            <pathway-xref db="Reactome" id="R-HSA-8851805" name="MET activates RAS signaling"/>
            <pathway-xref db="Reactome" id="R-DME-376176" name="Signaling by ROBO receptors"/>
            <pathway-xref db="Reactome" id="R-HSA-193692" name="Regulated proteolysis of p75NTR"/>
            <pathway-xref db="Reactome" id="R-MMU-6783783" name="Interleukin-10 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-448706" name="Interleukin-1 processing"/>
            <pathway-xref db="MetaCyc" id="PWY-6314" name="plumbagin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-5654228" name="Phospholipase C-mediated cascade, FGFR4"/>
            <pathway-xref db="Reactome" id="R-HSA-190322" name="FGFR4 ligand binding and activation"/>
            <pathway-xref db="Reactome" id="R-HSA-376176" name="Signaling by ROBO receptors"/>
            <pathway-xref db="Reactome" id="R-HSA-917977" name="Transferrin endocytosis and recycling"/>
            <pathway-xref db="MetaCyc" id="PWY-7473" name="avenacin A-1 biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-3000157" name="Laminin interactions"/>
            <pathway-xref db="Reactome" id="R-DME-209338" name="Assembly of the 'signalling complexes'"/>
            <pathway-xref db="MetaCyc" id="PWY-7716" name="penicillin G and penicillin V biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-877312" name="Regulation of IFNG signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-7647" name="ulvan degradation"/>
            <pathway-xref db="Reactome" id="R-GGA-1227892" name="TRAF6 mediated NF-kB activation"/>
            <pathway-xref db="MetaCyc" id="PWY-7475" name="des-methyl avenacin A-1 biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-HSA-167590" name="Nef Mediated CD4 Down-regulation"/>
            <pathway-xref db="Reactome" id="R-MMU-9664873" name="Pexophagy"/>
            <pathway-xref db="Reactome" id="R-HSA-1474244" name="Extracellular matrix organization"/>
            <pathway-xref db="MetaCyc" id="PWY-5286" name="anthocyanidin sophoroside metabolism"/>
            <pathway-xref db="Reactome" id="R-RNO-114608" name="Platelet degranulation"/>
            <pathway-xref db="Reactome" id="R-MMU-8875791" name="MET activates STAT3"/>
            <pathway-xref db="MetaCyc" id="PWY-6624" name="salicylate glucosides biosynthesis III"/>
            <pathway-xref db="Reactome" id="R-MMU-5654221" name="Phospholipase C-mediated cascade, FGFR2"/>
            <pathway-xref db="Reactome" id="R-MMU-9013106" name="RHOC GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-2022923" name="Dermatan sulfate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-5654704" name="SHC-mediated cascade:FGFR3"/>
            <pathway-xref db="Reactome" id="R-CFA-202427" name="Phosphorylation of CD3 and TCR zeta chains"/>
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            <pathway-xref db="MetaCyc" id="PWY-5473" name="hydroxycinnamic acid serotonin amides biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-109704" name="PI3K Cascade"/>
            <pathway-xref db="Reactome" id="R-MMU-210993" name="Tie2 Signaling"/>
            <pathway-xref db="Reactome" id="R-DRE-8849932" name="Synaptic adhesion-like molecules"/>
            <pathway-xref db="Reactome" id="R-DME-416700" name="Other semaphorin interactions"/>
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            <pathway-xref db="Reactome" id="R-RNO-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="MetaCyc" id="PWY-6784" name="cellulose and hemicellulose degradation (cellulolosome)"/>
            <pathway-xref db="Reactome" id="R-MMU-8856828" name="Clathrin-mediated endocytosis"/>
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            <pathway-xref db="Reactome" id="R-HSA-9703648" name="Signaling by FLT3 ITD and TKD mutants"/>
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            <pathway-xref db="MetaCyc" id="PWY-8058" name="2-deoxy-D-ribose degradation II"/>
            <pathway-xref db="Reactome" id="R-HSA-200425" name="Carnitine metabolism"/>
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            <pathway-xref db="MetaCyc" id="PWY-7577" name="ferrichrome biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-416482" name="G alpha (12/13) signalling events"/>
            <pathway-xref db="Reactome" id="R-MMU-5654693" name="FRS-mediated FGFR1 signaling"/>
            <pathway-xref db="Reactome" id="R-DME-209560" name="NF-kB is activated and signals survival"/>
            <pathway-xref db="MetaCyc" id="PWY-7940" name="lauryl-hydroxychlorobactene glucoside biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5672" name="ginsenosides biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-RNO-2029485" name="Role of phospholipids in phagocytosis"/>
            <pathway-xref db="Reactome" id="R-MMU-3928662" name="EPHB-mediated forward signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-6763" name="salicortin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-388844" name="Receptor-type tyrosine-protein phosphatases"/>
            <pathway-xref db="MetaCyc" id="PWY-5936" name="xyloglucan biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-MMU-5654700" name="FRS-mediated FGFR2 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-5292" name="vindoline, vindorosine and vinblastine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CFA-1433559" name="Regulation of KIT signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-9020702" name="Interleukin-1 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-1169408" name="ISG15 antiviral mechanism"/>
            <pathway-xref db="Reactome" id="R-HSA-445144" name="Signal transduction by L1"/>
            <pathway-xref db="Reactome" id="R-GGA-8854691" name="Interleukin-20 family signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-2022923" name="Dermatan sulfate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SPO-380972" name="Energy dependent regulation of mTOR by LKB1-AMPK"/>
            <pathway-xref db="Reactome" id="R-HSA-3928662" name="EPHB-mediated forward signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-5632681" name="Ligand-receptor interactions"/>
            <pathway-xref db="MetaCyc" id="PWY-7907" name="(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DRE-190375" name="FGFR2c ligand binding and activation"/>
            <pathway-xref db="MetaCyc" id="PWY-7555" name="alpha-cyclopiazonate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-6785807" name="Interleukin-4 and Interleukin-13 signaling"/>
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            <pathway-xref db="MetaCyc" id="PWY-7140" name="myricetin gentiobioside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-181430" name="Norepinephrine Neurotransmitter Release Cycle"/>
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            <pathway-xref db="Reactome" id="R-RNO-2022854" name="Keratan sulfate biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-RNO-74713" name="IRS activation"/>
            <pathway-xref db="MetaCyc" id="PWY-5994" name="palmitate biosynthesis I (type I fatty acid synthase)"/>
            <pathway-xref db="Reactome" id="R-RNO-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-CEL-913709" name="O-linked glycosylation of mucins"/>
            <pathway-xref db="Reactome" id="R-RNO-174577" name="Activation of C3 and C5"/>
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            <pathway-xref db="Reactome" id="R-CEL-5173214" name="O-glycosylation of TSR domain-containing proteins"/>
            <pathway-xref db="Reactome" id="R-HSA-3560783" name="Defective B4GALT7 causes EDS, progeroid type"/>
            <pathway-xref db="Reactome" id="R-RNO-373753" name="Nephrin family interactions"/>
            <pathway-xref db="MetaCyc" id="PWY-7100" name="spinosyn A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9669924" name="Masitinib-resistant KIT mutants"/>
            <pathway-xref db="MetaCyc" id="PWY-6525" name="stellariose and mediose biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9013404" name="RAC2 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-8241" name="Escherichia coli serotype O:71/Salmonella enterica serotype O:28ac O antigen biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-822" name="fructan biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-MMU-9010553" name="Regulation of expression of SLITs and ROBOs"/>
            <pathway-xref db="Reactome" id="R-BTA-1236977" name="Endosomal/Vacuolar pathway"/>
            <pathway-xref db="Reactome" id="R-RNO-9026527" name="Activated NTRK2 signals through PLCG1"/>
            <pathway-xref db="MetaCyc" id="PWY-5821" name="dalcochinin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-419037" name="NCAM1 interactions"/>
            <pathway-xref db="Reactome" id="R-MMU-8985586" name="SLIT2:ROBO1 increases RHOA activity"/>
            <pathway-xref db="MetaCyc" id="PWY-6471" name="peptidoglycan biosynthesis IV (Enterococcus faecium)"/>
            <pathway-xref db="Reactome" id="R-DRE-5654726" name="Negative regulation of FGFR1 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-9009391" name="Extra-nuclear estrogen signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-9020958" name="Interleukin-21 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-177929" name="Signaling by EGFR"/>
            <pathway-xref db="Reactome" id="R-DME-1810476" name="RIP-mediated NFkB activation via ZBP1"/>
            <pathway-xref db="Reactome" id="R-HSA-190370" name="FGFR1b ligand binding and activation"/>
            <pathway-xref db="Reactome" id="R-RNO-418594" name="G alpha (i) signalling events"/>
            <pathway-xref db="Reactome" id="R-MMU-8948216" name="Collagen chain trimerization"/>
            <pathway-xref db="Reactome" id="R-HSA-164940" name="Nef mediated downregulation of MHC class I complex cell surface expression"/>
            <pathway-xref db="Reactome" id="R-MMU-9013424" name="RHOV GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-2022857" name="Keratan sulfate degradation"/>
            <pathway-xref db="Reactome" id="R-RNO-1855183" name="Synthesis of IP2, IP, and Ins in the cytosol"/>
            <pathway-xref db="Reactome" id="R-HSA-9665686" name="Signaling by ERBB2 TMD/JMD mutants"/>
            <pathway-xref db="Reactome" id="R-HSA-9034793" name="Activated NTRK3 signals through PLCG1"/>
            <pathway-xref db="MetaCyc" id="PWY-7143" name="kaempferol gentiobioside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-446353" name="Cell-extracellular matrix interactions"/>
            <pathway-xref db="Reactome" id="R-RNO-5687128" name="MAPK6/MAPK4 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-6312" name="barbaloin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-399954" name="Sema3A PAK dependent Axon repulsion"/>
            <pathway-xref db="Reactome" id="R-HSA-216083" name="Integrin cell surface interactions"/>
            <pathway-xref db="Reactome" id="R-RNO-5683826" name="Surfactant metabolism"/>
            <pathway-xref db="Reactome" id="R-RNO-1971475" name="A tetrasaccharide linker sequence is required for GAG synthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7673" name="fusarin C biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-5654227" name="Phospholipase C-mediated cascade, FGFR3"/>
            <pathway-xref db="MetaCyc" id="PWY-7214" name="baicalein degradation (hydrogen peroxide detoxification)"/>
            <pathway-xref db="MetaCyc" id="PWY-6672" name="cis-geranyl-CoA degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-5620916" name="VxPx cargo-targeting to cilium"/>
            <pathway-xref db="Reactome" id="R-HSA-1839128" name="FGFR4 mutant receptor activation"/>
            <pathway-xref db="Reactome" id="R-MMU-186763" name="Downstream signal transduction"/>
            <pathway-xref db="MetaCyc" id="PWY-6722" name="candicidin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-5654726" name="Negative regulation of FGFR1 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-2172127" name="DAP12 interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-1059683" name="Interleukin-6 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-6811558" name="PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-354194" name="GRB2:SOS provides linkage to MAPK signaling for Integrins"/>
            <pathway-xref db="Reactome" id="R-HSA-9702605" name="pexidartinib-resistant FLT3 mutants"/>
            <pathway-xref db="Reactome" id="R-HSA-3785653" name="Myoclonic epilepsy of Lafora"/>
            <pathway-xref db="Reactome" id="R-RNO-2682334" name="EPH-Ephrin signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-2025928" name="Calcineurin activates NFAT"/>
            <pathway-xref db="MetaCyc" id="PWY-7468" name="benzoyl-beta-D-glucopyranose biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6737" name="starch degradation V"/>
            <pathway-xref db="Reactome" id="R-MMU-2029482" name="Regulation of actin dynamics for phagocytic cup formation"/>
            <pathway-xref db="MetaCyc" id="PWY-6717" name="(1,4)-beta-D-xylan degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-6148" name="tetrahydromethanopterin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-70268" name="Pyruvate metabolism"/>
            <pathway-xref db="MetaCyc" id="PWY-5875" name="staphyloxanthin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-4922" name="6-methoxymellein biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6366" name="D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-HSA-5655291" name="Signaling by FGFR4 in disease"/>
            <pathway-xref db="Reactome" id="R-HSA-3595177" name="Defective CHSY1 causes TPBS"/>
            <pathway-xref db="MetaCyc" id="PWY-6316" name="aromatic polyketides biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-933542" name="TRAF6 mediated NF-kB activation"/>
            <pathway-xref db="MetaCyc" id="PWY-5284" name="shisonin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6848" name="rutin degradation"/>
            <pathway-xref db="Reactome" id="R-DME-3134963" name="DEx/H-box helicases activate type I IFN and inflammatory cytokines production"/>
            <pathway-xref db="Reactome" id="R-HSA-350054" name="Notch-HLH transcription pathway"/>
            <pathway-xref db="MetaCyc" id="PWY-7859" name="jasmonoyl-L-isoleucine inactivation"/>
            <pathway-xref db="MetaCyc" id="PWYG-321" name="mycolate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-5083635" name="Defective B3GALTL causes Peters-plus syndrome (PpS)"/>
            <pathway-xref db="Reactome" id="R-DME-5654699" name="SHC-mediated cascade:FGFR2"/>
            <pathway-xref db="MetaCyc" id="PWY-8084" name="daurichromenate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-2243919" name="Crosslinking of collagen fibrils"/>
            <pathway-xref db="Reactome" id="R-MMU-5607761" name="Dectin-1 mediated noncanonical NF-kB signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-6802955" name="Paradoxical activation of RAF signaling by kinase inactive BRAF"/>
            <pathway-xref db="Reactome" id="R-HSA-3595174" name="Defective CHST14 causes EDS, musculocontractural type"/>
            <pathway-xref db="Reactome" id="R-MMU-9674555" name="Signaling by CSF3 (G-CSF)"/>
            <pathway-xref db="Reactome" id="R-MMU-5654706" name="FRS-mediated FGFR3 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-373760" name="L1CAM interactions"/>
            <pathway-xref db="MetaCyc" id="PWY-6922" name="L-Ndelta-acetylornithine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-204005" name="COPII-mediated vesicle transport"/>
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            <pathway-xref db="Reactome" id="R-SPO-163680" name="AMPK inhibits chREBP transcriptional activation activity"/>
            <pathway-xref db="Reactome" id="R-RNO-2132295" name="MHC class II antigen presentation"/>
            <pathway-xref db="Reactome" id="R-HSA-77387" name="Insulin receptor recycling"/>
            <pathway-xref db="Reactome" id="R-MMU-2428928" name="IRS-related events triggered by IGF1R"/>
            <pathway-xref db="MetaCyc" id="PWY-7661" name="protein N-glycosylation (Haloferax volcanii)"/>
            <pathway-xref db="Reactome" id="R-DRE-2682334" name="EPH-Ephrin signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9020933" name="Interleukin-23 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-1445148" name="Translocation of SLC2A4 (GLUT4) to the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-RNO-2404192" name="Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)"/>
            <pathway-xref db="Reactome" id="R-DME-77387" name="Insulin receptor recycling"/>
            <pathway-xref db="Reactome" id="R-BTA-9013405" name="RHOD GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DRE-210993" name="Tie2 Signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-5654732" name="Negative regulation of FGFR3 signaling"/>
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            <pathway-xref db="Reactome" id="R-HSA-2871809" name="FCERI mediated Ca+2 mobilization"/>
            <pathway-xref db="Reactome" id="R-RNO-1474228" name="Degradation of the extracellular matrix"/>
            <pathway-xref db="Reactome" id="R-HSA-9702518" name="STAT5 activation downstream of FLT3 ITD mutants"/>
            <pathway-xref db="Reactome" id="R-HSA-4755510" name="SUMOylation of immune response proteins"/>
            <pathway-xref db="MetaCyc" id="PWY-8119" name="microcin B17 biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7670" name="fusaridione A biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-8207" name="Escherichia coli serotype O:85/Salmonella enterica serotype O:17 O antigen biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-7694" name="zwittermicin A biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-BTA-983170" name="Antigen Presentation: Folding, assembly and peptide loading of class I MHC"/>
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            <pathway-xref db="Reactome" id="R-MMU-182971" name="EGFR downregulation"/>
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            <pathway-xref db="Reactome" id="R-MMU-196108" name="Pregnenolone biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-977606" name="Regulation of Complement cascade"/>
            <pathway-xref db="Reactome" id="R-MMU-1442490" name="Collagen degradation"/>
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            <pathway-xref db="MetaCyc" id="PWY-7599" name="anditomin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-2730905" name="Role of LAT2/NTAL/LAB on calcium mobilization"/>
            <pathway-xref db="MetaCyc" id="PWY-7401" name="crotonate fermentation (to acetate and cyclohexane carboxylate)"/>
            <pathway-xref db="Reactome" id="R-HSA-9702636" name="tandutinib-resistant FLT3 mutants"/>
            <pathway-xref db="MetaCyc" id="PWY-5774" name="saponin biosynthesis IV"/>
            <pathway-xref db="Reactome" id="R-DME-5654688" name="SHC-mediated cascade:FGFR1"/>
            <pathway-xref db="Reactome" id="R-HSA-8875513" name="MET interacts with TNS proteins"/>
            <pathway-xref db="Reactome" id="R-CEL-9013420" name="RHOU GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-190322" name="FGFR4 ligand binding and activation"/>
            <pathway-xref db="Reactome" id="R-GGA-5658623" name="FGFRL1 modulation of FGFR1 signaling"/>
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            <pathway-xref db="MetaCyc" id="PWY-5822" name="trichloroethene degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-5307" name="gentiodelphin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-216083" name="Integrin cell surface interactions"/>
            <pathway-xref db="Reactome" id="R-RNO-445144" name="Signal transduction by L1"/>
            <pathway-xref db="MetaCyc" id="PWY-2902" name="cytokinin-O-glucosides biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8000" name="vitamin K degradation"/>
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            <pathway-xref db="Reactome" id="R-HSA-2024101" name="CS/DS degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-9013026" name="RHOB GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-1169091" name="Activation of NF-kappaB in B cells"/>
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            <pathway-xref db="Reactome" id="R-RNO-5654219" name="Phospholipase C-mediated cascade: FGFR1"/>
            <pathway-xref db="Reactome" id="R-MMU-9034013" name="NTF3 activates NTRK3 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-1632852" name="Macroautophagy"/>
            <pathway-xref db="Reactome" id="R-HSA-5576892" name="Phase 0 - rapid depolarisation"/>
            <pathway-xref db="Reactome" id="R-MMU-9696264" name="RND3 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-9013695" name="NOTCH4 Intracellular Domain Regulates Transcription"/>
            <pathway-xref db="Reactome" id="R-HSA-190373" name="FGFR1c ligand binding and activation"/>
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            <pathway-xref db="Reactome" id="R-HSA-2024096" name="HS-GAG degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-5654719" name="SHC-mediated cascade:FGFR4"/>
            <pathway-xref db="Reactome" id="R-HSA-9027276" name="Erythropoietin activates Phosphoinositide-3-kinase (PI3K)"/>
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            <pathway-xref db="MetaCyc" id="PWY-7897" name="flavonoid di-C-glucosylation"/>
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            <pathway-xref db="Reactome" id="R-HSA-9673768" name="Signaling by membrane-tethered fusions of PDGFRA or PDGFRB"/>
            <pathway-xref db="Reactome" id="R-DME-214416" name="Phosphorylated REL is cleaved by and dissociates from DREDD"/>
            <pathway-xref db="MetaCyc" id="PWY-5469" name="sesamin biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-RNO-389948" name="PD-1 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-8205" name="Escherichia coli serotype O:77/Salmonella enterica serotype O:6,14 O antigen biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-5268" name="salvianin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DRE-5654219" name="Phospholipase C-mediated cascade: FGFR1"/>
            <pathway-xref db="Reactome" id="R-HSA-5173105" name="O-linked glycosylation"/>
            <pathway-xref db="Reactome" id="R-CEL-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-7056" name="daphnin interconversion"/>
            <pathway-xref db="Reactome" id="R-DRE-399956" name="CRMPs in Sema3A signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-8984722" name="Interleukin-35 Signalling"/>
            <pathway-xref db="Reactome" id="R-HSA-9031628" name="NGF-stimulated transcription"/>
            <pathway-xref db="Reactome" id="R-HSA-1810476" name="RIP-mediated NFkB activation via ZBP1"/>
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            <pathway-xref db="Reactome" id="R-MMU-5635838" name="Activation of SMO"/>
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            <pathway-xref db="Reactome" id="R-HSA-447043" name="Neurofascin interactions"/>
            <pathway-xref db="MetaCyc" id="PWY-7692" name="bikaverin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-354192" name="Integrin signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-5603029" name="IkBA variant leads to EDA-ID"/>
            <pathway-xref db="Reactome" id="R-RNO-3928664" name="Ephrin signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-7602" name="icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)"/>
            <pathway-xref db="MetaCyc" id="PWY-7687" name="stipitatate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7375" name="mRNA capping I"/>
            <pathway-xref db="Reactome" id="R-CEL-3928663" name="EPHA-mediated growth cone collapse"/>
            <pathway-xref db="MetaCyc" id="PWY-6379" name="alcaligin biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-MMU-202433" name="Generation of second messenger molecules"/>
            <pathway-xref db="Reactome" id="R-MMU-3928663" name="EPHA-mediated growth cone collapse"/>
            <pathway-xref db="MetaCyc" id="PWY-8204" name="Salmonella enterica serotype O:54 O antigen biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-HSA-2871837" name="FCERI mediated NF-kB activation"/>
            <pathway-xref db="Reactome" id="R-HSA-446107" name="Type I hemidesmosome assembly"/>
            <pathway-xref db="Reactome" id="R-HSA-1266695" name="Interleukin-7 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-173623" name="Classical antibody-mediated complement activation"/>
            <pathway-xref db="Reactome" id="R-RNO-166663" name="Initial triggering of complement"/>
            <pathway-xref db="Reactome" id="R-MMU-74713" name="IRS activation"/>
            <pathway-xref db="MetaCyc" id="PWY-6930" name="phenolic malonylglucosides biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-MMU-9027284" name="Erythropoietin activates RAS"/>
            <pathway-xref db="MetaCyc" id="PWY-7213" name="wogonin metabolism"/>
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            <pathway-xref db="Reactome" id="R-SSC-202433" name="Generation of second messenger molecules"/>
            <pathway-xref db="MetaCyc" id="PWY-7405" name="aurachin RE biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-9014843" name="Interleukin-33 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-449836" name="Other interleukin signaling"/>
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            <pathway-xref db="MetaCyc" id="PWY-5666" name="alpha-solanine/alpha-chaconine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-RNO-3000178" name="ECM proteoglycans"/>
            <pathway-xref db="Reactome" id="R-MMU-9603381" name="Activated NTRK3 signals through PI3K"/>
            <pathway-xref db="Reactome" id="R-DRE-3928664" name="Ephrin signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-7633" name="calycosin 7-O-glucoside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-9013424" name="RHOV GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-9013420" name="RHOU GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-7984" name="acinetobactin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-2033519" name="Activated point mutants of FGFR2"/>
            <pathway-xref db="MetaCyc" id="PWY-8235" name="Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-202733" name="Cell surface interactions at the vascular wall"/>
            <pathway-xref db="MetaCyc" id="PWY-7133" name="quercetin glucoside degradation (Allium)"/>
            <pathway-xref db="Reactome" id="R-DME-428542" name="Regulation of commissural axon pathfinding by SLIT and ROBO"/>
            <pathway-xref db="Reactome" id="R-RNO-2024096" name="HS-GAG degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-447038" name="NrCAM interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-420597" name="Nectin/Necl trans heterodimerization"/>
            <pathway-xref db="Reactome" id="R-HSA-1474228" name="Degradation of the extracellular matrix"/>
            <pathway-xref db="Reactome" id="R-CEL-373752" name="Netrin-1 signaling"/>
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            <pathway-xref db="Reactome" id="R-RNO-2428928" name="IRS-related events triggered by IGF1R"/>
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            <pathway-xref db="Reactome" id="R-RNO-2168880" name="Scavenging of heme from plasma"/>
            <pathway-xref db="Reactome" id="R-HSA-9702590" name="gilteritinib-resistant FLT3 mutants"/>
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            <pathway-xref db="MetaCyc" id="PWY-8230" name="Salmonella enterica serotype O:13 O antigen biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-8211" name="Escherichia coli serotype O:7 O antigen biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-7247" name="beta-D-glucuronide and D-glucuronate degradation"/>
            <pathway-xref db="Reactome" id="R-SSC-1236974" name="ER-Phagosome pathway"/>
            <pathway-xref db="Reactome" id="R-RNO-432722" name="Golgi Associated Vesicle Biogenesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-5129" name="sphingolipid biosynthesis (plants)"/>
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            <pathway-xref db="Reactome" id="R-RNO-983170" name="Antigen Presentation: Folding, assembly and peptide loading of class I MHC"/>
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            <pathway-xref db="MetaCyc" id="PWY-8176" name="geraniol biosynthesis (cytosol)"/>
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            <pathway-xref db="Reactome" id="R-MMU-2214320" name="Anchoring fibril formation"/>
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            <pathway-xref db="MetaCyc" id="PWY-8226" name="Escherichia coli serotype O:152 O antigen biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-MMU-2129379" name="Molecules associated with elastic fibres"/>
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            <pathway-xref db="Reactome" id="R-SSC-2160916" name="Hyaluronan uptake and degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-5381" name="NAD salvage (plants)"/>
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            <pathway-xref db="Reactome" id="R-MMU-525793" name="Myogenesis"/>
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            <pathway-xref db="Reactome" id="R-DRE-190372" name="FGFR3c ligand binding and activation"/>
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            <pathway-xref db="Reactome" id="R-MMU-9696273" name="RND1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-110056" name="MAPK3 (ERK1) activation"/>
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            <pathway-xref db="MetaCyc" id="PWY-1981" name="indole-3-acetate inactivation III"/>
            <pathway-xref db="Reactome" id="R-DRE-5654700" name="FRS-mediated FGFR2 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-6785807" name="Interleukin-4 and Interleukin-13 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-8964046" name="VLDL clearance"/>
            <pathway-xref db="MetaCyc" id="PWY-7979" name="protein O-mannosylation III (mammals, core M3)"/>
            <pathway-xref db="Reactome" id="R-HSA-9013423" name="RAC3 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-6310" name="aloesone biosynthesis II"/>
            <pathway-xref db="Reactome" id="R-HSA-389359" name="CD28 dependent Vav1 pathway"/>
            <pathway-xref db="MetaCyc" id="PWY-7191" name="kaempferol diglycoside biosynthesis (pollen-specific)"/>
            <pathway-xref db="Reactome" id="R-HSA-9013420" name="RHOU GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-7815" name="poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)"/>
            <pathway-xref db="Reactome" id="R-HSA-212676" name="Dopamine Neurotransmitter Release Cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-842" name="starch degradation I"/>
            <pathway-xref db="Reactome" id="R-RNO-416476" name="G alpha (q) signalling events"/>
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            <pathway-xref db="MetaCyc" id="PWY-7129" name="quercetin glucoside biosynthesis (Allium)"/>
            <pathway-xref db="Reactome" id="R-HSA-9020702" name="Interleukin-1 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9013508" name="NOTCH3 Intracellular Domain Regulates Transcription"/>
            <pathway-xref db="Reactome" id="R-MMU-193634" name="Axonal growth inhibition (RHOA activation)"/>
            <pathway-xref db="Reactome" id="R-MMU-1462054" name="Alpha-defensins"/>
            <pathway-xref db="Reactome" id="R-BTA-388841" name="Costimulation by the CD28 family"/>
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            <pathway-xref db="MetaCyc" id="PWY-5466" name="matairesinol biosynthesis"/>
            <pathway-xref db="Reactome" id="R-GGA-373920" name="Pyruvate metabolism"/>
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            <pathway-xref db="Reactome" id="R-BTA-5628897" name="TP53 Regulates Metabolic Genes"/>
            <pathway-xref db="Reactome" id="R-MMU-190377" name="FGFR2b ligand binding and activation"/>
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            <pathway-xref db="Reactome" id="R-RNO-933542" name="TRAF6 mediated NF-kB activation"/>
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            <pathway-xref db="MetaCyc" id="PWY-7460" name="2-O-acetyl-3-O-trans-coutarate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5310" name="superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)"/>
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            <pathway-xref db="Reactome" id="R-MMU-4420097" name="VEGFA-VEGFR2 Pathway"/>
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            <pathway-xref db="Reactome" id="R-RNO-181429" name="Serotonin Neurotransmitter Release Cycle"/>
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            <pathway-xref db="Reactome" id="R-HSA-9020956" name="Interleukin-27 signaling"/>
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            <pathway-xref db="Reactome" id="R-RNO-1266695" name="Interleukin-7 signaling"/>
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            <pathway-xref db="Reactome" id="R-MMU-8984722" name="Interleukin-35 Signalling"/>
            <pathway-xref db="MetaCyc" id="PWY-6378" name="putrebactin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-GGA-198933" name="Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"/>
            <pathway-xref db="Reactome" id="R-MMU-432722" name="Golgi Associated Vesicle Biogenesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-7738" name="polyacyltrehalose biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-MMU-2029481" name="FCGR activation"/>
            <pathway-xref db="Reactome" id="R-CEL-3928664" name="Ephrin signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-3121" name="linamarin degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-5628897" name="TP53 Regulates Metabolic Genes"/>
            <pathway-xref db="Reactome" id="R-HSA-2197563" name="NOTCH2 intracellular domain regulates transcription"/>
            <pathway-xref db="Reactome" id="R-HSA-9026519" name="Activated NTRK2 signals through RAS"/>
            <pathway-xref db="Reactome" id="R-MMU-9026527" name="Activated NTRK2 signals through PLCG1"/>
            <pathway-xref db="Reactome" id="R-SSC-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-264642" name="Acetylcholine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-8851708" name="Signaling by FGFR2 IIIa TM"/>
            <pathway-xref db="Reactome" id="R-CFA-5690714" name="CD22 mediated BCR regulation"/>
            <pathway-xref db="Reactome" id="R-HSA-2586552" name="Signaling by Leptin"/>
            <pathway-xref db="Reactome" id="R-MMU-983170" name="Antigen Presentation: Folding, assembly and peptide loading of class I MHC"/>
            <pathway-xref db="Reactome" id="R-MMU-9028731" name="Activated NTRK2 signals through FRS2 and FRS3"/>
            <pathway-xref db="Reactome" id="R-RNO-186763" name="Downstream signal transduction"/>
            <pathway-xref db="Reactome" id="R-HSA-5654700" name="FRS-mediated FGFR2 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-5173105" name="O-linked glycosylation"/>
            <pathway-xref db="Reactome" id="R-CFA-1810476" name="RIP-mediated NFkB activation via ZBP1"/>
            <pathway-xref db="Reactome" id="R-MMU-8865999" name="MET activates PTPN11"/>
            <pathway-xref db="MetaCyc" id="PWY-7367" name="phosphatidylcholine resynthesis via glycerophosphocholine"/>
            <pathway-xref db="Reactome" id="R-HSA-196108" name="Pregnenolone biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8039" name="mitomycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-3000178" name="ECM proteoglycans"/>
            <pathway-xref db="Reactome" id="R-CFA-1169091" name="Activation of NF-kappaB in B cells"/>
            <pathway-xref db="MetaCyc" id="PWY-7735" name="echinomycin and triostin A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-8983711" name="OAS antiviral response"/>
            <pathway-xref db="MetaCyc" id="PWY-7621" name="autoinducer CAI-1 biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-166665" name="Terminal pathway of complement"/>
            <pathway-xref db="MetaCyc" id="PWY-8047" name="bryostatin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7711" name="calonectrin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-2151201" name="Transcriptional activation of mitochondrial biogenesis"/>
            <pathway-xref db="Reactome" id="R-MMU-70268" name="Pyruvate metabolism"/>
            <pathway-xref db="Reactome" id="R-SSC-9013106" name="RHOC GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-419037" name="NCAM1 interactions"/>
            <pathway-xref db="MetaCyc" id="PWY-6948" name="sitosterol degradation to androstenedione"/>
            <pathway-xref db="Reactome" id="R-DME-5654695" name="PI-3K cascade:FGFR2"/>
            <pathway-xref db="Reactome" id="R-CFA-2024101" name="CS/DS degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-5083628" name="Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3"/>
            <pathway-xref db="Reactome" id="R-SSC-2172127" name="DAP12 interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-186797" name="Signaling by PDGF"/>
            <pathway-xref db="Reactome" id="R-DRE-5654719" name="SHC-mediated cascade:FGFR4"/>
            <pathway-xref db="Reactome" id="R-MMU-5654689" name="PI-3K cascade:FGFR1"/>
            <pathway-xref db="Reactome" id="R-RNO-210500" name="Glutamate Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-8875513" name="MET interacts with TNS proteins"/>
            <pathway-xref db="Reactome" id="R-RNO-9014843" name="Interleukin-33 signaling"/>
            <pathway-xref db="Reactome" id="R-CEL-376172" name="DSCAM interactions"/>
            <pathway-xref db="MetaCyc" id="PWY-8251" name="Escherichia coli serotype O:2 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-9027284" name="Erythropoietin activates RAS"/>
            <pathway-xref db="Reactome" id="R-RNO-5654693" name="FRS-mediated FGFR1 signaling"/>
            <pathway-xref db="Reactome" id="R-CEL-2682334" name="EPH-Ephrin signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-2024101" name="CS/DS degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-1306955" name="GRB7 events in ERBB2 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-8133" name="succinoglycan biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-2033514" name="FGFR3 mutant receptor activation"/>
            <pathway-xref db="Reactome" id="R-SSC-9013404" name="RAC2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-GGA-9028731" name="Activated NTRK2 signals through FRS2 and FRS3"/>
            <pathway-xref db="Reactome" id="R-HSA-5607764" name="CLEC7A (Dectin-1) signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-6527" name="stachyose degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-8040" name="ansatrienin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8272" name="Escherichia coli serotype O:49 O antigen biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7137" name="quercetin gentiotetraside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-399955" name="SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion"/>
            <pathway-xref db="Reactome" id="R-DME-5621575" name="CD209 (DC-SIGN) signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-190374" name="FGFR1c and Klotho ligand binding and activation"/>
            <pathway-xref db="Reactome" id="R-DME-190377" name="FGFR2b ligand binding and activation"/>
            <pathway-xref db="Reactome" id="R-MMU-3214841" name="PKMTs methylate histone lysines"/>
            <pathway-xref db="Reactome" id="R-RNO-5654719" name="SHC-mediated cascade:FGFR4"/>
            <pathway-xref db="MetaCyc" id="PWY-8252" name="Escherichia coli serotype O:50 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-198933" name="Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"/>
            <pathway-xref db="MetaCyc" id="PWY-8236" name="Salmonella enterica serotype O:39 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-909733" name="Interferon alpha/beta signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9680187" name="Signaling by extracellular domain mutants of KIT"/>
            <pathway-xref db="Reactome" id="R-RNO-8856828" name="Clathrin-mediated endocytosis"/>
            <pathway-xref db="MetaCyc" id="PWY-6364" name="D-myo-inositol (1,3,4)-trisphosphate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7727" name="docosahexaenoate biosynthesis IV (4-desaturase, mammals)"/>
            <pathway-xref db="Reactome" id="R-RNO-8851805" name="MET activates RAS signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-1170546" name="Prolactin receptor signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-761" name="rhizobactin 1021 biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-MMU-354194" name="GRB2:SOS provides linkage to MAPK signaling for Integrins"/>
            <pathway-xref db="Reactome" id="R-DME-209968" name="Thyroxine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7563" name="bassianin and desmethylbassianin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7212" name="baicalein metabolism"/>
            <pathway-xref db="Reactome" id="R-HSA-380259" name="Loss of Nlp from mitotic centrosomes"/>
            <pathway-xref db="Reactome" id="R-CFA-1266695" name="Interleukin-7 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-8851907" name="MET activates PI3K/AKT signaling"/>
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            <pathway-xref db="Reactome" id="R-CFA-2871837" name="FCERI mediated NF-kB activation"/>
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            <pathway-xref db="Reactome" id="R-RNO-437239" name="Recycling pathway of L1"/>
            <pathway-xref db="Reactome" id="R-HSA-1433557" name="Signaling by SCF-KIT"/>
            <pathway-xref db="Reactome" id="R-RNO-9013148" name="CDC42 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-5619070" name="Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT)"/>
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            <pathway-xref db="MetaCyc" id="PWY-7900" name="glycogen biosynthesis III (from alpha-maltose 1-phosphate)"/>
            <pathway-xref db="MetaCyc" id="PWY-5105" name="hesperitin glycoside biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-HSA-112411" name="MAPK1 (ERK2) activation"/>
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            <pathway-xref db="Reactome" id="R-MMU-2122947" name="NOTCH1 Intracellular Domain Regulates Transcription"/>
            <pathway-xref db="MetaCyc" id="PWY-8157" name="avenanthramide biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9664422" name="FCGR3A-mediated phagocytosis"/>
            <pathway-xref db="MetaCyc" id="PWY-7050" name="icosapentaenoate biosynthesis IV (bacteria)"/>
            <pathway-xref db="Reactome" id="R-MMU-512988" name="Interleukin-3, Interleukin-5 and GM-CSF signaling"/>
            <pathway-xref db="Reactome" id="R-CFA-202424" name="Downstream TCR signaling"/>
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            <pathway-xref db="Reactome" id="R-HSA-1251985" name="Nuclear signaling by ERBB4"/>
            <pathway-xref db="Reactome" id="R-MMU-447043" name="Neurofascin interactions"/>
            <pathway-xref db="Reactome" id="R-MMU-416476" name="G alpha (q) signalling events"/>
            <pathway-xref db="MetaCyc" id="PWY-5846" name="colchicine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5313" name="superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)"/>
            <pathway-xref db="Reactome" id="R-HSA-3656243" name="Defective ST3GAL3 causes MCT12 and EIEE15"/>
            <pathway-xref db="Reactome" id="R-MMU-912694" name="Regulation of IFNA signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-8875656" name="MET receptor recycling"/>
            <pathway-xref db="Reactome" id="R-RNO-446353" name="Cell-extracellular matrix interactions"/>
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            <pathway-xref db="Reactome" id="R-HSA-977443" name="GABA receptor activation"/>
            <pathway-xref db="Reactome" id="R-CEL-8853383" name="Lysosomal oligosaccharide catabolism"/>
            <pathway-xref db="Reactome" id="R-HSA-354192" name="Integrin signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-7708" name="lyngbyatoxin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-1236974" name="ER-Phagosome pathway"/>
            <pathway-xref db="MetaCyc" id="PWY-7946" name="sarcinaxanthin diglucoside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-2206302" name="MPS I - Hurler syndrome"/>
            <pathway-xref db="Reactome" id="R-MMU-399954" name="Sema3A PAK dependent Axon repulsion"/>
            <pathway-xref db="Reactome" id="R-DME-5654710" name="PI-3K cascade:FGFR3"/>
            <pathway-xref db="Reactome" id="R-RNO-2172127" name="DAP12 interactions"/>
            <pathway-xref db="MetaCyc" id="PWY-7883" name="anhydromuropeptides recycling II"/>
            <pathway-xref db="Reactome" id="R-RNO-8963896" name="HDL assembly"/>
            <pathway-xref db="Reactome" id="R-DME-5632681" name="Ligand-receptor interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-2129379" name="Molecules associated with elastic fibres"/>
            <pathway-xref db="MetaCyc" id="PWY-7960" name="rhabduscin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-8853383" name="Lysosomal oligosaccharide catabolism"/>
            <pathway-xref db="Reactome" id="R-HSA-391160" name="Signal regulatory protein family interactions"/>
            <pathway-xref db="MetaCyc" id="PWY-7029" name="terminal olefins biosynthesis II"/>
            <pathway-xref db="Reactome" id="R-HSA-877312" name="Regulation of IFNG signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-5654687" name="Downstream signaling of activated FGFR1"/>
            <pathway-xref db="Reactome" id="R-HSA-6806942" name="MET Receptor Activation"/>
            <pathway-xref db="Reactome" id="R-MMU-9035034" name="RHOF GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-5160" name="rose anthocyanin biosynthesis I (via cyanidin 5-O-beta-D-glucoside)"/>
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            <pathway-xref db="Reactome" id="R-HSA-5654695" name="PI-3K cascade:FGFR2"/>
            <pathway-xref db="MetaCyc" id="PWY-7150" name="polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)"/>
            <pathway-xref db="Reactome" id="R-HSA-5655253" name="Signaling by FGFR2 in disease"/>
            <pathway-xref db="MetaCyc" id="PWY-6731" name="starch degradation III"/>
            <pathway-xref db="MetaCyc" id="PWY-5139" name="pelargonidin conjugates biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7151" name="polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)"/>
            <pathway-xref db="MetaCyc" id="PWY-7819" name="poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9673767" name="Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants"/>
            <pathway-xref db="MetaCyc" id="PWY-5477" name="gallotannin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-6807004" name="Negative regulation of MET activity"/>
            <pathway-xref db="Reactome" id="R-MMU-200425" name="Carnitine metabolism"/>
            <pathway-xref db="Reactome" id="R-MMU-5687128" name="MAPK6/MAPK4 signaling"/>
            <pathway-xref db="Reactome" id="R-DME-209400" name="Transcriptional activtion by phosphorylated DL/DIF dimer"/>
            <pathway-xref db="Reactome" id="R-HSA-8851680" name="Butyrophilin (BTN) family interactions"/>
            <pathway-xref db="Reactome" id="R-MMU-1650814" name="Collagen biosynthesis and modifying enzymes"/>
            <pathway-xref db="Reactome" id="R-CFA-8985947" name="Interleukin-9 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-8849932" name="Synaptic adhesion-like molecules"/>
            <pathway-xref db="Reactome" id="R-MMU-1433559" name="Regulation of KIT signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-2404192" name="Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)"/>
            <pathway-xref db="Reactome" id="R-MMU-177504" name="Retrograde neurotrophin signalling"/>
            <pathway-xref db="Reactome" id="R-RNO-5673001" name="RAF/MAP kinase cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-879415" name="Advanced glycosylation endproduct receptor signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-912526" name="Interleukin receptor SHC signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-6415" name="L-ascorbate biosynthesis V (euglena, D-galacturonate pathway)"/>
            <pathway-xref db="MetaCyc" id="PWY-6679" name="jadomycin biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-DRE-5654720" name="PI-3K cascade:FGFR4"/>
            <pathway-xref db="Reactome" id="R-MMU-2029485" name="Role of phospholipids in phagocytosis"/>
            <pathway-xref db="Reactome" id="R-MMU-9020702" name="Interleukin-1 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-5674135" name="MAP2K and MAPK activation"/>
            <pathway-xref db="MetaCyc" id="PWY-7168" name="flavonol acylglucoside biosynthesis I - kaempferol derivatives"/>
            <pathway-xref db="MetaCyc" id="PWY-7623" name="astaxanthin dirhamnoside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-2022857" name="Keratan sulfate degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-2160916" name="Hyaluronan uptake and degradation"/>
            <pathway-xref db="Reactome" id="R-CFA-5673001" name="RAF/MAP kinase cascade"/>
            <pathway-xref db="MetaCyc" id="PWY-7743" name="dimycocerosyl triglycosyl phenolphthiocerol biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8237" name="Escherichia coli serotype O:1B/Salmonella enterica serotype O:42 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-1650814" name="Collagen biosynthesis and modifying enzymes"/>
            <pathway-xref db="Reactome" id="R-DRE-418990" name="Adherens junctions interactions"/>
            <pathway-xref db="Reactome" id="R-MMU-1971475" name="A tetrasaccharide linker sequence is required for GAG synthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6971" name="oleandomycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-114608" name="Platelet degranulation"/>
            <pathway-xref db="Reactome" id="R-MMU-9705462" name="Inactivation of CSF3 (G-CSF) signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-6735" name="starch degradation IV"/>
            <pathway-xref db="Reactome" id="R-RNO-74751" name="Insulin receptor signalling cascade"/>
            <pathway-xref db="Reactome" id="R-MMU-9696270" name="RND2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-418886" name="Netrin mediated repulsion signals"/>
            <pathway-xref db="Reactome" id="R-RNO-912526" name="Interleukin receptor SHC signaling"/>
            <pathway-xref db="Reactome" id="R-DRE-5673001" name="RAF/MAP kinase cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-9696273" name="RND1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-180534" name="Vpu mediated degradation of CD4"/>
            <pathway-xref db="Reactome" id="R-RNO-1474244" name="Extracellular matrix organization"/>
            <pathway-xref db="MetaCyc" id="PWY-7913" name="firefly bioluminescence"/>
            <pathway-xref db="MetaCyc" id="PWY-6456" name="serinol biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-399955" name="SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion"/>
            <pathway-xref db="Reactome" id="R-CEL-399956" name="CRMPs in Sema3A signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-109704" name="PI3K Cascade"/>
            <pathway-xref db="Reactome" id="R-GGA-2424491" name="DAP12 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-5654720" name="PI-3K cascade:FGFR4"/>
            <pathway-xref db="Reactome" id="R-RNO-9009391" name="Extra-nuclear estrogen signaling"/>
            <pathway-xref db="Reactome" id="R-CFA-9020958" name="Interleukin-21 signaling"/>
            <pathway-xref db="Reactome" id="R-SSC-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-HSA-5683826" name="Surfactant metabolism"/>
            <pathway-xref db="Reactome" id="R-MMU-5684264" name="MAP3K8 (TPL2)-dependent MAPK1/3 activation"/>
            <pathway-xref db="MetaCyc" id="PWY-6762" name="salicylate glucosides biosynthesis IV"/>
            <pathway-xref db="Reactome" id="R-RNO-388844" name="Receptor-type tyrosine-protein phosphatases"/>
            <pathway-xref db="Reactome" id="R-MMU-2672351" name="Stimuli-sensing channels"/>
            <pathway-xref db="Reactome" id="R-MMU-1660661" name="Sphingolipid de novo biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-1250342" name="PI3K events in ERBB4 signaling"/>
            <pathway-xref db="Reactome" id="R-BTA-114608" name="Platelet degranulation"/>
            <pathway-xref db="MetaCyc" id="PWY-8055" name="palmitoyl ethanolamide biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-982772" name="Growth hormone receptor signaling"/>
            <pathway-xref db="Reactome" id="R-DME-525793" name="Myogenesis"/>
            <pathway-xref db="Reactome" id="R-RNO-5620916" name="VxPx cargo-targeting to cilium"/>
            <pathway-xref db="Reactome" id="R-GGA-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-HSA-380270" name="Recruitment of mitotic centrosome proteins and complexes"/>
            <pathway-xref db="Reactome" id="R-MMU-2424491" name="DAP12 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-7450" name="anthocyanidin modification (Arabidopsis)"/>
            <pathway-xref db="MetaCyc" id="PWY-5926" name="afrormosin conjugates interconversion"/>
            <pathway-xref db="MetaCyc" id="PWY-7354" name="aclacinomycin biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-MMU-917977" name="Transferrin endocytosis and recycling"/>
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            <pathway-xref db="MetaCyc" id="PWY-8152" name="androstenedione degradation II (anaerobic)"/>
            <pathway-xref db="Reactome" id="R-HSA-6811558" name="PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-6190" name="2,4-dichlorotoluene degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-8012" name="mupirocin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-432142" name="Platelet sensitization by LDL"/>
            <pathway-xref db="Reactome" id="R-HSA-9664565" name="Signaling by ERBB2 KD Mutants"/>
            <pathway-xref db="Reactome" id="R-BTA-114608" name="Platelet degranulation"/>
            <pathway-xref db="MetaCyc" id="PWY-735" name="jasmonic acid biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7300" name="ecdysone and 20-hydroxyecdysone biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-177929" name="Signaling by EGFR"/>
            <pathway-xref db="MetaCyc" id="PWY-6863" name="pyruvate fermentation to hexanol (engineered)"/>
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            <pathway-xref db="MetaCyc" id="PWY-7787" name="L-threitol degradation"/>
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            <pathway-xref db="Reactome" id="R-MMU-72764" name="Eukaryotic Translation Termination"/>
            <pathway-xref db="Reactome" id="R-RNO-6811558" name="PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-6672" name="cis-geranyl-CoA degradation"/>
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            <pathway-xref db="MetaCyc" id="PWY-6061" name="bile acid biosynthesis, neutral pathway"/>
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            <pathway-xref db="Reactome" id="R-RNO-196791" name="Vitamin D (calciferol) metabolism"/>
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            <pathway-xref db="MetaCyc" id="PWY-6539" name="(Z)-phenylmethanethial S-oxide biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-8065" name="chlorpyrifos degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-6368" name="3-phosphoinositide degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-8132" name="S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation III"/>
            <pathway-xref db="Reactome" id="R-MMU-975634" name="Retinoid metabolism and transport"/>
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            <pathway-xref db="Reactome" id="R-RNO-6785631" name="ERBB2 Regulates Cell Motility"/>
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            <pathway-xref db="Reactome" id="R-CEL-6798695" name="Neutrophil degranulation"/>
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            <pathway-xref db="Reactome" id="R-MMU-8964046" name="VLDL clearance"/>
            <pathway-xref db="MetaCyc" id="PWY-5818" name="validamycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-5638303" name="Inhibition of Signaling by Overexpressed EGFR"/>
            <pathway-xref db="MetaCyc" id="PWY-7741" name="phthiocerol biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-CEL-72702" name="Ribosomal scanning and start codon recognition"/>
            <pathway-xref db="MetaCyc" id="PWY-7511" name="protein ubiquitination"/>
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            <pathway-xref db="MetaCyc" id="PWY-5666" name="alpha-solanine/alpha-chaconine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7884" name="lipoprotein posttranslational modification"/>
            <pathway-xref db="MetaCyc" id="PWY-5290" name="secologanin and strictosidine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-180336" name="SHC1 events in EGFR signaling"/>
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            <pathway-xref db="MetaCyc" id="PWY-6883" name="pyruvate fermentation to butanol II (engineered)"/>
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            <pathway-xref db="Reactome" id="R-HSA-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7333" name="UDP-N-acetyl-alpha-D-fucosamine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5491" name="diethylphosphate degradation"/>
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            <pathway-xref db="MetaCyc" id="PWY-8247" name="(Kdo)2-lipid A biosynthesis (P. gingivalis)"/>
            <pathway-xref db="Reactome" id="R-CEL-72649" name="Translation initiation complex formation"/>
            <pathway-xref db="MetaCyc" id="PWY-7825" name="juglone degradation"/>
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            <pathway-xref db="MetaCyc" id="PWY-6686" name="mannosylglucosylglycerate biosynthesis I"/>
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          <signature-library-release library="GENE3D" version="4.3.0"/>
        </signature>
        <model-ac>3s94B02</model-ac>
        <locations>
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              <hmmer3-location-fragment start="211" end="511" dc-status="CONTINUOUS"/>
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          </hmmer3-location>
        </locations>
      </hmmer3-match>
      <hmmer3-match evalue="1.0E-90" score="303.5">
        <signature ac="PF07714" desc="Protein tyrosine and serine/threonine kinase" name="PK_Tyr_Ser-Thr">
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            <pathway-xref db="Reactome" id="R-HSA-8983432" name="Interleukin-15 signaling"/>
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            <pathway-xref db="Reactome" id="R-MMU-6806942" name="MET Receptor Activation"/>
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            <pathway-xref db="Reactome" id="R-HSA-5627117" name="RHO GTPases Activate ROCKs"/>
            <pathway-xref db="Reactome" id="R-MMU-5654706" name="FRS-mediated FGFR3 signaling"/>
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            <pathway-xref db="Reactome" id="R-MMU-190374" name="FGFR1c and Klotho ligand binding and activation"/>
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            <pathway-xref db="Reactome" id="R-BTA-75892" name="Platelet Adhesion to exposed collagen"/>
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            <pathway-xref db="Reactome" id="R-HSA-1236974" name="ER-Phagosome pathway"/>
            <pathway-xref db="Reactome" id="R-MMU-416482" name="G alpha (12/13) signalling events"/>
            <pathway-xref db="Reactome" id="R-HSA-77387" name="Insulin receptor recycling"/>
            <pathway-xref db="Reactome" id="R-RNO-69231" name="Cyclin D associated events in G1"/>
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            <pathway-xref db="Reactome" id="R-MMU-2428928" name="IRS-related events triggered by IGF1R"/>
            <pathway-xref db="Reactome" id="R-HSA-8875656" name="MET receptor recycling"/>
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            <pathway-xref db="MetaCyc" id="PWY-6952" name="glycerophosphodiester degradation"/>
            <pathway-xref db="Reactome" id="R-GGA-456926" name="Thrombin signalling through proteinase activated receptors (PARs)"/>
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            <pathway-xref db="Reactome" id="R-DRE-456926" name="Thrombin signalling through proteinase activated receptors (PARs)"/>
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            <pathway-xref db="Reactome" id="R-HSA-9020933" name="Interleukin-23 signaling"/>
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            <pathway-xref db="Reactome" id="R-HSA-6806942" name="MET Receptor Activation"/>
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            <pathway-xref db="Reactome" id="R-DRE-5654221" name="Phospholipase C-mediated cascade, FGFR2"/>
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            <pathway-xref db="Reactome" id="R-DME-418594" name="G alpha (i) signalling events"/>
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            <pathway-xref db="Reactome" id="R-DME-432142" name="Platelet sensitization by LDL"/>
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            <pathway-xref db="Reactome" id="R-DRE-5654720" name="PI-3K cascade:FGFR4"/>
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            <pathway-xref db="Reactome" id="R-DME-5654688" name="SHC-mediated cascade:FGFR1"/>
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            <pathway-xref db="Reactome" id="R-HSA-9674396" name="Imatinib-resistant PDGFR mutants"/>
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            <pathway-xref db="Reactome" id="R-HSA-74751" name="Insulin receptor signalling cascade"/>
            <pathway-xref db="Reactome" id="R-DME-8934903" name="Receptor Mediated Mitophagy"/>
            <pathway-xref db="Reactome" id="R-RNO-190322" name="FGFR4 ligand binding and activation"/>
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            <pathway-xref db="Reactome" id="R-RNO-2173791" name="TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)"/>
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            <pathway-xref db="Reactome" id="R-CEL-8941858" name="Regulation of RUNX3 expression and activity"/>
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            <pathway-xref db="Reactome" id="R-GGA-114604" name="GPVI-mediated activation cascade"/>
            <pathway-xref db="Reactome" id="R-RNO-216083" name="Integrin cell surface interactions"/>
            <pathway-xref db="Reactome" id="R-DDI-9020702" name="Interleukin-1 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-445144" name="Signal transduction by L1"/>
            <pathway-xref db="Reactome" id="R-GGA-4420097" name="VEGFA-VEGFR2 Pathway"/>
            <pathway-xref db="Reactome" id="R-HSA-937041" name="IKK complex recruitment mediated by RIP1"/>
            <pathway-xref db="Reactome" id="R-CFA-5673001" name="RAF/MAP kinase cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-430116" name="GP1b-IX-V activation signalling"/>
            <pathway-xref db="Reactome" id="R-MMU-1266695" name="Interleukin-7 signaling"/>
            <pathway-xref db="Reactome" id="R-DRE-399955" name="SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion"/>
            <pathway-xref db="Reactome" id="R-HSA-1169091" name="Activation of NF-kappaB in B cells"/>
            <pathway-xref db="Reactome" id="R-HSA-9702624" name="sorafenib-resistant FLT3 mutants"/>
            <pathway-xref db="Reactome" id="R-MMU-112411" name="MAPK1 (ERK2) activation"/>
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            <pathway-xref db="Reactome" id="R-DME-209338" name="Assembly of the 'signalling complexes'"/>
            <pathway-xref db="MetaCyc" id="PWY-7716" name="penicillin G and penicillin V biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-7647" name="ulvan degradation"/>
            <pathway-xref db="Reactome" id="R-GGA-1227892" name="TRAF6 mediated NF-kB activation"/>
            <pathway-xref db="MetaCyc" id="PWY-7475" name="des-methyl avenacin A-1 biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-5286" name="anthocyanidin sophoroside metabolism"/>
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            <pathway-xref db="MetaCyc" id="PWY-6624" name="salicylate glucosides biosynthesis III"/>
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            <pathway-xref db="Reactome" id="R-CFA-202427" name="Phosphorylation of CD3 and TCR zeta chains"/>
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            <pathway-xref db="MetaCyc" id="PWY-5473" name="hydroxycinnamic acid serotonin amides biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-109704" name="PI3K Cascade"/>
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            <pathway-xref db="MetaCyc" id="PWY-6784" name="cellulose and hemicellulose degradation (cellulolosome)"/>
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            <pathway-xref db="MetaCyc" id="PWY-8058" name="2-deoxy-D-ribose degradation II"/>
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            <pathway-xref db="MetaCyc" id="PWY-7577" name="ferrichrome biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-416482" name="G alpha (12/13) signalling events"/>
            <pathway-xref db="Reactome" id="R-MMU-5654693" name="FRS-mediated FGFR1 signaling"/>
            <pathway-xref db="Reactome" id="R-DME-209560" name="NF-kB is activated and signals survival"/>
            <pathway-xref db="MetaCyc" id="PWY-7940" name="lauryl-hydroxychlorobactene glucoside biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5672" name="ginsenosides biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7139" name="sesaminol glucoside biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6039" name="chlorogenic acid biosynthesis I"/>
            <pathway-xref db="Reactome" id="R-RNO-2029485" name="Role of phospholipids in phagocytosis"/>
            <pathway-xref db="Reactome" id="R-MMU-3928662" name="EPHB-mediated forward signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-6763" name="salicortin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-388844" name="Receptor-type tyrosine-protein phosphatases"/>
            <pathway-xref db="MetaCyc" id="PWY-5936" name="xyloglucan biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-2644606" name="Constitutive Signaling by NOTCH1 PEST Domain Mutants"/>
            <pathway-xref db="MetaCyc" id="PWY-8210" name="pyrrolomycin biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-MMU-5654700" name="FRS-mediated FGFR2 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-5292" name="vindoline, vindorosine and vinblastine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CFA-1433559" name="Regulation of KIT signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-9020702" name="Interleukin-1 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-1169408" name="ISG15 antiviral mechanism"/>
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            <pathway-xref db="Reactome" id="R-GGA-8854691" name="Interleukin-20 family signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-2022923" name="Dermatan sulfate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SPO-380972" name="Energy dependent regulation of mTOR by LKB1-AMPK"/>
            <pathway-xref db="Reactome" id="R-HSA-3928662" name="EPHB-mediated forward signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-5632681" name="Ligand-receptor interactions"/>
            <pathway-xref db="MetaCyc" id="PWY-7907" name="(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DRE-190375" name="FGFR2c ligand binding and activation"/>
            <pathway-xref db="MetaCyc" id="PWY-7555" name="alpha-cyclopiazonate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-6785807" name="Interleukin-4 and Interleukin-13 signaling"/>
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            <pathway-xref db="MetaCyc" id="PWY-7140" name="myricetin gentiobioside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-181430" name="Norepinephrine Neurotransmitter Release Cycle"/>
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            <pathway-xref db="Reactome" id="R-RNO-2022854" name="Keratan sulfate biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-RNO-74713" name="IRS activation"/>
            <pathway-xref db="MetaCyc" id="PWY-5994" name="palmitate biosynthesis I (type I fatty acid synthase)"/>
            <pathway-xref db="Reactome" id="R-RNO-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-CEL-913709" name="O-linked glycosylation of mucins"/>
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            <pathway-xref db="Reactome" id="R-MMU-389357" name="CD28 dependent PI3K/Akt signaling"/>
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            <pathway-xref db="Reactome" id="R-HSA-3560783" name="Defective B4GALT7 causes EDS, progeroid type"/>
            <pathway-xref db="Reactome" id="R-RNO-373753" name="Nephrin family interactions"/>
            <pathway-xref db="MetaCyc" id="PWY-7100" name="spinosyn A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9669924" name="Masitinib-resistant KIT mutants"/>
            <pathway-xref db="MetaCyc" id="PWY-6525" name="stellariose and mediose biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9013404" name="RAC2 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-8241" name="Escherichia coli serotype O:71/Salmonella enterica serotype O:28ac O antigen biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-BTA-1236977" name="Endosomal/Vacuolar pathway"/>
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            <pathway-xref db="MetaCyc" id="PWY-5821" name="dalcochinin biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-6471" name="peptidoglycan biosynthesis IV (Enterococcus faecium)"/>
            <pathway-xref db="Reactome" id="R-DRE-5654726" name="Negative regulation of FGFR1 signaling"/>
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            <pathway-xref db="Reactome" id="R-MMU-9020958" name="Interleukin-21 signaling"/>
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            <pathway-xref db="Reactome" id="R-MMU-2022857" name="Keratan sulfate degradation"/>
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            <pathway-xref db="MetaCyc" id="PWY-7143" name="kaempferol gentiobioside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-446353" name="Cell-extracellular matrix interactions"/>
            <pathway-xref db="Reactome" id="R-RNO-5687128" name="MAPK6/MAPK4 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-6312" name="barbaloin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-399954" name="Sema3A PAK dependent Axon repulsion"/>
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            <pathway-xref db="MetaCyc" id="PWY-7468" name="benzoyl-beta-D-glucopyranose biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-6717" name="(1,4)-beta-D-xylan degradation"/>
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            <pathway-xref db="Reactome" id="R-HSA-70268" name="Pyruvate metabolism"/>
            <pathway-xref db="MetaCyc" id="PWY-5875" name="staphyloxanthin biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-5284" name="shisonin biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-DME-3134963" name="DEx/H-box helicases activate type I IFN and inflammatory cytokines production"/>
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            <pathway-xref db="MetaCyc" id="PWY-7859" name="jasmonoyl-L-isoleucine inactivation"/>
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            <pathway-xref db="Reactome" id="R-RNO-2132295" name="MHC class II antigen presentation"/>
            <pathway-xref db="Reactome" id="R-HSA-77387" name="Insulin receptor recycling"/>
            <pathway-xref db="Reactome" id="R-MMU-2428928" name="IRS-related events triggered by IGF1R"/>
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            <pathway-xref db="Reactome" id="R-DRE-2682334" name="EPH-Ephrin signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9020933" name="Interleukin-23 signaling"/>
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            <pathway-xref db="Reactome" id="R-DME-77387" name="Insulin receptor recycling"/>
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            <pathway-xref db="MetaCyc" id="PWY-8119" name="microcin B17 biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-8207" name="Escherichia coli serotype O:85/Salmonella enterica serotype O:17 O antigen biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-HSA-114604" name="GPVI-mediated activation cascade"/>
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            <pathway-xref db="MetaCyc" id="PWY-6824" name="justicidin B biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-HSA-9706377" name="FLT3 signaling by CBL mutants"/>
            <pathway-xref db="Reactome" id="R-MMU-196108" name="Pregnenolone biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-977606" name="Regulation of Complement cascade"/>
            <pathway-xref db="Reactome" id="R-MMU-1442490" name="Collagen degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-6809371" name="Formation of the cornified envelope"/>
            <pathway-xref db="Reactome" id="R-BTA-380972" name="Energy dependent regulation of mTOR by LKB1-AMPK"/>
            <pathway-xref db="Reactome" id="R-GGA-449836" name="Other interleukin signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-7599" name="anditomin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-2730905" name="Role of LAT2/NTAL/LAB on calcium mobilization"/>
            <pathway-xref db="MetaCyc" id="PWY-7401" name="crotonate fermentation (to acetate and cyclohexane carboxylate)"/>
            <pathway-xref db="Reactome" id="R-HSA-9702636" name="tandutinib-resistant FLT3 mutants"/>
            <pathway-xref db="MetaCyc" id="PWY-5774" name="saponin biosynthesis IV"/>
            <pathway-xref db="Reactome" id="R-DME-5654688" name="SHC-mediated cascade:FGFR1"/>
            <pathway-xref db="Reactome" id="R-HSA-8875513" name="MET interacts with TNS proteins"/>
            <pathway-xref db="Reactome" id="R-CEL-9013420" name="RHOU GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-190322" name="FGFR4 ligand binding and activation"/>
            <pathway-xref db="Reactome" id="R-GGA-5658623" name="FGFRL1 modulation of FGFR1 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-9609523" name="Insertion of tail-anchored proteins into the endoplasmic reticulum membrane"/>
            <pathway-xref db="Reactome" id="R-DME-214844" name="DL and DIF homodimers complexed with CACT are all phosphorylated in the TL receptor 'signalling complex'"/>
            <pathway-xref db="Reactome" id="R-HSA-5690714" name="CD22 mediated BCR regulation"/>
            <pathway-xref db="MetaCyc" id="PWY-5822" name="trichloroethene degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-5307" name="gentiodelphin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-216083" name="Integrin cell surface interactions"/>
            <pathway-xref db="Reactome" id="R-RNO-445144" name="Signal transduction by L1"/>
            <pathway-xref db="MetaCyc" id="PWY-2902" name="cytokinin-O-glucosides biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8000" name="vitamin K degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-8036" name="chaxamycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-2024101" name="CS/DS degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-9013026" name="RHOB GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-1169091" name="Activation of NF-kappaB in B cells"/>
            <pathway-xref db="Reactome" id="R-HSA-2022928" name="HS-GAG biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-112411" name="MAPK1 (ERK2) activation"/>
            <pathway-xref db="Reactome" id="R-RNO-5654219" name="Phospholipase C-mediated cascade: FGFR1"/>
            <pathway-xref db="Reactome" id="R-MMU-9034013" name="NTF3 activates NTRK3 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-1632852" name="Macroautophagy"/>
            <pathway-xref db="Reactome" id="R-HSA-5576892" name="Phase 0 - rapid depolarisation"/>
            <pathway-xref db="Reactome" id="R-MMU-9696264" name="RND3 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-9013695" name="NOTCH4 Intracellular Domain Regulates Transcription"/>
            <pathway-xref db="Reactome" id="R-HSA-190373" name="FGFR1c ligand binding and activation"/>
            <pathway-xref db="Reactome" id="R-GGA-9032759" name="NTRK2 activates RAC1"/>
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            <pathway-xref db="Reactome" id="R-MMU-8852405" name="Signaling by MST1"/>
            <pathway-xref db="Reactome" id="R-HSA-2024096" name="HS-GAG degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-5654719" name="SHC-mediated cascade:FGFR4"/>
            <pathway-xref db="Reactome" id="R-HSA-9027276" name="Erythropoietin activates Phosphoinositide-3-kinase (PI3K)"/>
            <pathway-xref db="MetaCyc" id="PWY-5048" name="rosmarinic acid biosynthesis I"/>
            <pathway-xref db="MetaCyc" id="PWY-7897" name="flavonoid di-C-glucosylation"/>
            <pathway-xref db="Reactome" id="R-RNO-202424" name="Downstream TCR signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-380284" name="Loss of proteins required for interphase microtubule organization from the centrosome"/>
            <pathway-xref db="Reactome" id="R-HSA-9615017" name="FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes"/>
            <pathway-xref db="Reactome" id="R-HSA-9673768" name="Signaling by membrane-tethered fusions of PDGFRA or PDGFRB"/>
            <pathway-xref db="Reactome" id="R-DME-214416" name="Phosphorylated REL is cleaved by and dissociates from DREDD"/>
            <pathway-xref db="MetaCyc" id="PWY-5469" name="sesamin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7145" name="genistin gentiobioside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-389948" name="PD-1 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-8205" name="Escherichia coli serotype O:77/Salmonella enterica serotype O:6,14 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-174577" name="Activation of C3 and C5"/>
            <pathway-xref db="MetaCyc" id="PWY-5268" name="salvianin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DRE-5654219" name="Phospholipase C-mediated cascade: FGFR1"/>
            <pathway-xref db="Reactome" id="R-HSA-5173105" name="O-linked glycosylation"/>
            <pathway-xref db="Reactome" id="R-CEL-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-7056" name="daphnin interconversion"/>
            <pathway-xref db="Reactome" id="R-DRE-399956" name="CRMPs in Sema3A signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-8984722" name="Interleukin-35 Signalling"/>
            <pathway-xref db="Reactome" id="R-HSA-9031628" name="NGF-stimulated transcription"/>
            <pathway-xref db="Reactome" id="R-HSA-1810476" name="RIP-mediated NFkB activation via ZBP1"/>
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            <pathway-xref db="Reactome" id="R-HSA-3560801" name="Defective B3GAT3 causes JDSSDHD"/>
            <pathway-xref db="Reactome" id="R-MMU-5635838" name="Activation of SMO"/>
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            <pathway-xref db="Reactome" id="R-HSA-447043" name="Neurofascin interactions"/>
            <pathway-xref db="MetaCyc" id="PWY-7692" name="bikaverin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-354192" name="Integrin signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-5603029" name="IkBA variant leads to EDA-ID"/>
            <pathway-xref db="Reactome" id="R-RNO-3928664" name="Ephrin signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-7602" name="icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)"/>
            <pathway-xref db="MetaCyc" id="PWY-7687" name="stipitatate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7375" name="mRNA capping I"/>
            <pathway-xref db="Reactome" id="R-CEL-3928663" name="EPHA-mediated growth cone collapse"/>
            <pathway-xref db="MetaCyc" id="PWY-6379" name="alcaligin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7074" name="phenylethanol glycoconjugate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-202433" name="Generation of second messenger molecules"/>
            <pathway-xref db="Reactome" id="R-MMU-3928663" name="EPHA-mediated growth cone collapse"/>
            <pathway-xref db="MetaCyc" id="PWY-8204" name="Salmonella enterica serotype O:54 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DRE-195399" name="VEGF binds to VEGFR leading to receptor dimerization"/>
            <pathway-xref db="Reactome" id="R-HSA-1462054" name="Alpha-defensins"/>
            <pathway-xref db="Reactome" id="R-HSA-2871837" name="FCERI mediated NF-kB activation"/>
            <pathway-xref db="Reactome" id="R-HSA-446107" name="Type I hemidesmosome assembly"/>
            <pathway-xref db="Reactome" id="R-HSA-1266695" name="Interleukin-7 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-173623" name="Classical antibody-mediated complement activation"/>
            <pathway-xref db="Reactome" id="R-RNO-166663" name="Initial triggering of complement"/>
            <pathway-xref db="Reactome" id="R-MMU-74713" name="IRS activation"/>
            <pathway-xref db="MetaCyc" id="PWY-6930" name="phenolic malonylglucosides biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6627" name="salinosporamide A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-9027284" name="Erythropoietin activates RAS"/>
            <pathway-xref db="MetaCyc" id="PWY-7213" name="wogonin metabolism"/>
            <pathway-xref db="MetaCyc" id="PWY-6720" name="toyocamycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SSC-202433" name="Generation of second messenger molecules"/>
            <pathway-xref db="MetaCyc" id="PWY-7405" name="aurachin RE biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-9014843" name="Interleukin-33 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-449836" name="Other interleukin signaling"/>
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            <pathway-xref db="MetaCyc" id="PWY-5666" name="alpha-solanine/alpha-chaconine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-RNO-3000178" name="ECM proteoglycans"/>
            <pathway-xref db="Reactome" id="R-MMU-9603381" name="Activated NTRK3 signals through PI3K"/>
            <pathway-xref db="Reactome" id="R-DRE-3928664" name="Ephrin signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-7633" name="calycosin 7-O-glucoside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-9013424" name="RHOV GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-9013420" name="RHOU GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-7984" name="acinetobactin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-2033519" name="Activated point mutants of FGFR2"/>
            <pathway-xref db="MetaCyc" id="PWY-8235" name="Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-202733" name="Cell surface interactions at the vascular wall"/>
            <pathway-xref db="MetaCyc" id="PWY-7133" name="quercetin glucoside degradation (Allium)"/>
            <pathway-xref db="Reactome" id="R-DME-428542" name="Regulation of commissural axon pathfinding by SLIT and ROBO"/>
            <pathway-xref db="Reactome" id="R-RNO-2024096" name="HS-GAG degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-447038" name="NrCAM interactions"/>
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            <pathway-xref db="Reactome" id="R-HSA-5620912" name="Anchoring of the basal body to the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-RNO-2428928" name="IRS-related events triggered by IGF1R"/>
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            <pathway-xref db="MetaCyc" id="PWY-8224" name="Escherichia coli serotype O:157/Salmonella enterica serotype O:30 O antigen biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-MMU-8874081" name="MET activates PTK2 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-140837" name="Intrinsic Pathway of Fibrin Clot Formation"/>
            <pathway-xref db="Reactome" id="R-MMU-389948" name="PD-1 signaling"/>
            <pathway-xref db="Reactome" id="R-DME-399955" name="SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion"/>
            <pathway-xref db="Reactome" id="R-RNO-1462054" name="Alpha-defensins"/>
            <pathway-xref db="MetaCyc" id="PWY-5312" name="superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)"/>
            <pathway-xref db="Reactome" id="R-HSA-1839122" name="Signaling by activated point mutants of FGFR1"/>
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            <pathway-xref db="Reactome" id="R-DME-209394" name="Transcriptional activtion and repression of REL-68 target genes"/>
            <pathway-xref db="MetaCyc" id="PWY-7521" name="3-(4-sulfophenyl)butanoate degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7238" name="sucrose biosynthesis II"/>
            <pathway-xref db="Reactome" id="R-HSA-190377" name="FGFR2b ligand binding and activation"/>
            <pathway-xref db="Reactome" id="R-RNO-3000157" name="Laminin interactions"/>
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            <pathway-xref db="Reactome" id="R-DRE-5654704" name="SHC-mediated cascade:FGFR3"/>
            <pathway-xref db="Reactome" id="R-HSA-375276" name="Peptide ligand-binding receptors"/>
            <pathway-xref db="Reactome" id="R-MMU-5654720" name="PI-3K cascade:FGFR4"/>
            <pathway-xref db="Reactome" id="R-HSA-388841" name="Costimulation by the CD28 family"/>
            <pathway-xref db="Reactome" id="R-DRE-5654732" name="Negative regulation of FGFR3 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9034864" name="Activated NTRK3 signals through RAS"/>
            <pathway-xref db="Reactome" id="R-MMU-210500" name="Glutamate Neurotransmitter Release Cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-8053" name="anandamide biosynthesis II"/>
            <pathway-xref db="Reactome" id="R-HSA-190375" name="FGFR2c ligand binding and activation"/>
            <pathway-xref db="Reactome" id="R-HSA-9702581" name="crenolanib-resistant FLT3 mutants"/>
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            <pathway-xref db="Reactome" id="R-RNO-5223345" name="Miscellaneous transport and binding events"/>
            <pathway-xref db="MetaCyc" id="PWY-7612" name="chaetoglobosin A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-8951664" name="Neddylation"/>
            <pathway-xref db="Reactome" id="R-HSA-9702632" name="sunitinib-resistant FLT3 mutants"/>
            <pathway-xref db="MetaCyc" id="PWY-5800" name="xylan biosynthesis"/>
            <pathway-xref db="Reactome" id="R-GGA-3928663" name="EPHA-mediated growth cone collapse"/>
            <pathway-xref db="Reactome" id="R-CFA-9020702" name="Interleukin-1 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-8854691" name="Interleukin-20 family signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-6749" name="CMP-legionaminate biosynthesis I"/>
            <pathway-xref db="Reactome" id="R-DME-5620916" name="VxPx cargo-targeting to cilium"/>
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            <pathway-xref db="Reactome" id="R-RNO-186797" name="Signaling by PDGF"/>
            <pathway-xref db="Reactome" id="R-MMU-5673001" name="RAF/MAP kinase cascade"/>
            <pathway-xref db="Reactome" id="R-DME-5654733" name="Negative regulation of FGFR4 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-5654219" name="Phospholipase C-mediated cascade: FGFR1"/>
            <pathway-xref db="Reactome" id="R-MMU-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-DME-416482" name="G alpha (12/13) signalling events"/>
            <pathway-xref db="Reactome" id="R-DME-190374" name="FGFR1c and Klotho ligand binding and activation"/>
            <pathway-xref db="Reactome" id="R-CEL-3000157" name="Laminin interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-9669936" name="Sorafenib-resistant KIT mutants"/>
            <pathway-xref db="Reactome" id="R-MMU-1257604" name="PIP3 activates AKT signaling"/>
            <pathway-xref db="Reactome" id="R-CEL-416550" name="Sema4D mediated inhibition of cell attachment and migration"/>
            <pathway-xref db="Reactome" id="R-RNO-2129379" name="Molecules associated with elastic fibres"/>
            <pathway-xref db="Reactome" id="R-RNO-1632852" name="Macroautophagy"/>
            <pathway-xref db="Reactome" id="R-MMU-195399" name="VEGF binds to VEGFR leading to receptor dimerization"/>
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            <pathway-xref db="Reactome" id="R-HSA-4420332" name="Defective B3GALT6 causes EDSP2 and SEMDJL1"/>
            <pathway-xref db="Reactome" id="R-RNO-977606" name="Regulation of Complement cascade"/>
            <pathway-xref db="Reactome" id="R-CEL-399954" name="Sema3A PAK dependent Axon repulsion"/>
            <pathway-xref db="Reactome" id="R-HSA-373753" name="Nephrin family interactions"/>
            <pathway-xref db="Reactome" id="R-MMU-5683826" name="Surfactant metabolism"/>
            <pathway-xref db="Reactome" id="R-DME-1169091" name="Activation of NF-kappaB in B cells"/>
            <pathway-xref db="Reactome" id="R-GGA-1236977" name="Endosomal/Vacuolar pathway"/>
            <pathway-xref db="Reactome" id="R-MMU-1307965" name="betaKlotho-mediated ligand binding"/>
            <pathway-xref db="MetaCyc" id="PWY-5399" name="betacyanin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-2428933" name="SHC-related events triggered by IGF1R"/>
            <pathway-xref db="Reactome" id="R-HSA-9020591" name="Interleukin-12 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-7157" name="eupatolitin 3-O-glucoside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-8851907" name="MET activates PI3K/AKT signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-8032" name="chloramphenicol biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-MMU-8963896" name="HDL assembly"/>
            <pathway-xref db="Reactome" id="R-RNO-264876" name="Insulin processing"/>
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            <pathway-xref db="Reactome" id="R-RNO-449836" name="Other interleukin signaling"/>
            <pathway-xref db="Reactome" id="R-SPO-200425" name="Carnitine metabolism"/>
            <pathway-xref db="MetaCyc" id="PWY-7543" name="5-N-acetylardeemin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-418594" name="G alpha (i) signalling events"/>
            <pathway-xref db="Reactome" id="R-MMU-433692" name="Proton-coupled monocarboxylate transport"/>
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            <pathway-xref db="Reactome" id="R-SSC-9020591" name="Interleukin-12 signaling"/>
            <pathway-xref db="Reactome" id="R-GGA-163125" name="Post-translational modification: synthesis of GPI-anchored proteins"/>
            <pathway-xref db="Reactome" id="R-HSA-2132295" name="MHC class II antigen presentation"/>
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            <pathway-xref db="Reactome" id="R-MMU-110056" name="MAPK3 (ERK1) activation"/>
            <pathway-xref db="Reactome" id="R-CEL-114608" name="Platelet degranulation"/>
            <pathway-xref db="MetaCyc" id="PWY-7987" name="vanchrobactin biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-DME-419037" name="NCAM1 interactions"/>
            <pathway-xref db="MetaCyc" id="PWY-5265" name="peptidoglycan biosynthesis II (staphylococci)"/>
            <pathway-xref db="MetaCyc" id="PWY-622" name="starch biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7981" name="alpha-dystroglycan glycosylation"/>
            <pathway-xref db="Reactome" id="R-HSA-2022090" name="Assembly of collagen fibrils and other multimeric structures"/>
            <pathway-xref db="MetaCyc" id="PWY-2881" name="cytokinins 7-N-glucoside biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7660" name="tryptoquialanine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DRE-190373" name="FGFR1c ligand binding and activation"/>
            <pathway-xref db="Reactome" id="R-MMU-2682334" name="EPH-Ephrin signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-5339" name="chalcone 2'-O-glucoside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-376176" name="Signaling by ROBO receptors"/>
            <pathway-xref db="MetaCyc" id="PWY-7256" name="cyanidin diglucoside biosynthesis (acyl-glucose dependent)"/>
            <pathway-xref db="MetaCyc" id="PWY-7134" name="rutin degradation (plants)"/>
            <pathway-xref db="Reactome" id="R-MMU-912526" name="Interleukin receptor SHC signaling"/>
            <pathway-xref db="Reactome" id="R-DME-4755510" name="SUMOylation of immune response proteins"/>
            <pathway-xref db="Reactome" id="R-MMU-9014826" name="Interleukin-36 pathway"/>
            <pathway-xref db="MetaCyc" id="PWY-7018" name="paromomycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CFA-445989" name="TAK1 activates NFkB by phosphorylation and activation of IKKs complex"/>
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            <pathway-xref db="Reactome" id="R-HSA-9669929" name="Regorafenib-resistant KIT mutants"/>
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            <pathway-xref db="MetaCyc" id="PWY-6010" name="apigenin glycosides biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-3000170" name="Syndecan interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-187024" name="NGF-independant TRKA activation"/>
            <pathway-xref db="Reactome" id="R-HSA-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-2979096" name="NOTCH2 Activation and Transmission of Signal to the Nucleus"/>
            <pathway-xref db="MetaCyc" id="PWY-7002" name="4-hydroxyacetophenone degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-844456" name="The NLRP3 inflammasome"/>
            <pathway-xref db="Reactome" id="R-HSA-170968" name="Frs2-mediated activation"/>
            <pathway-xref db="Reactome" id="R-RNO-74752" name="Signaling by Insulin receptor"/>
            <pathway-xref db="Reactome" id="R-RNO-5628897" name="TP53 Regulates Metabolic Genes"/>
            <pathway-xref db="Reactome" id="R-RNO-376172" name="DSCAM interactions"/>
            <pathway-xref db="Reactome" id="R-RNO-1236977" name="Endosomal/Vacuolar pathway"/>
            <pathway-xref db="MetaCyc" id="PWY-8243" name="colanic acid (Escherichia coli K12) biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-437239" name="Recycling pathway of L1"/>
            <pathway-xref db="Reactome" id="R-RNO-2029481" name="FCGR activation"/>
            <pathway-xref db="Reactome" id="R-HSA-114608" name="Platelet degranulation"/>
            <pathway-xref db="Reactome" id="R-SCE-3322077" name="Glycogen synthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-428540" name="Activation of RAC1"/>
            <pathway-xref db="Reactome" id="R-RNO-1236974" name="ER-Phagosome pathway"/>
            <pathway-xref db="MetaCyc" id="PWY-8045" name="cylindrospermopsin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-SSC-202424" name="Downstream TCR signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-198745" name="Signalling to STAT3"/>
            <pathway-xref db="MetaCyc" id="PWY-83" name="monolignol glucosides biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-8853383" name="Lysosomal oligosaccharide catabolism"/>
            <pathway-xref db="Reactome" id="R-MMU-380972" name="Energy dependent regulation of mTOR by LKB1-AMPK"/>
            <pathway-xref db="MetaCyc" id="PWY-7719" name="CMP-diacetamido-8-epilegionaminic acid biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5380" name="A series fagopyritols biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-2024101" name="CS/DS degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-430116" name="GP1b-IX-V activation signalling"/>
            <pathway-xref db="Reactome" id="R-CFA-3134963" name="DEx/H-box helicases activate type I IFN and inflammatory cytokines production"/>
            <pathway-xref db="Reactome" id="R-MMU-1266695" name="Interleukin-7 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9702624" name="sorafenib-resistant FLT3 mutants"/>
            <pathway-xref db="Reactome" id="R-HSA-1660661" name="Sphingolipid de novo biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SSC-202427" name="Phosphorylation of CD3 and TCR zeta chains"/>
            <pathway-xref db="Reactome" id="R-BTA-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-HSA-9705462" name="Inactivation of CSF3 (G-CSF) signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-210991" name="Basigin interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-8852405" name="Signaling by MST1"/>
            <pathway-xref db="Reactome" id="R-MMU-2024096" name="HS-GAG degradation"/>
            <pathway-xref db="Reactome" id="R-DRE-186797" name="Signaling by PDGF"/>
            <pathway-xref db="Reactome" id="R-RNO-6804756" name="Regulation of TP53 Activity through Phosphorylation"/>
            <pathway-xref db="Reactome" id="R-HSA-5654719" name="SHC-mediated cascade:FGFR4"/>
            <pathway-xref db="Reactome" id="R-HSA-416550" name="Sema4D mediated inhibition of cell attachment and migration"/>
            <pathway-xref db="Reactome" id="R-HSA-9609523" name="Insertion of tail-anchored proteins into the endoplasmic reticulum membrane"/>
            <pathway-xref db="Reactome" id="R-HSA-9013026" name="RHOB GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-2559582" name="Senescence-Associated Secretory Phenotype (SASP)"/>
            <pathway-xref db="Reactome" id="R-DME-9009391" name="Extra-nuclear estrogen signaling"/>
            <pathway-xref db="Reactome" id="R-DME-375165" name="NCAM signaling for neurite out-growth"/>
            <pathway-xref db="MetaCyc" id="PWY-7740" name="beta-D-mannosyl phosphomycoketide biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-2160916" name="Hyaluronan uptake and degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-5140745" name="WNT5A-dependent internalization of FZD2, FZD5 and ROR2"/>
            <pathway-xref db="Reactome" id="R-RNO-445095" name="Interaction between L1 and Ankyrins"/>
            <pathway-xref db="Reactome" id="R-HSA-1442490" name="Collagen degradation"/>
            <pathway-xref db="Reactome" id="R-RNO-418889" name="Caspase activation via Dependence Receptors in the absence of ligand"/>
            <pathway-xref db="Reactome" id="R-HSA-182218" name="Nef Mediated CD8 Down-regulation"/>
            <pathway-xref db="MetaCyc" id="PWY-8152" name="androstenedione degradation II (anaerobic)"/>
            <pathway-xref db="MetaCyc" id="PWY-361" name="phenylpropanoid biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-5687128" name="MAPK6/MAPK4 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9664565" name="Signaling by ERBB2 KD Mutants"/>
            <pathway-xref db="Reactome" id="R-RNO-5654689" name="PI-3K cascade:FGFR1"/>
            <pathway-xref db="Reactome" id="R-DRE-5654689" name="PI-3K cascade:FGFR1"/>
            <pathway-xref db="Reactome" id="R-RNO-8957275" name="Post-translational protein phosphorylation"/>
            <pathway-xref db="Reactome" id="R-MMU-525793" name="Myogenesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8253" name="Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-2424491" name="DAP12 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-4086398" name="Ca2+ pathway"/>
            <pathway-xref db="MetaCyc" id="PWY-7921" name="protein O-mannosylation I (yeast)"/>
            <pathway-xref db="MetaCyc" id="PWY-7530" name="Escherichia coli serotype O:104 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-5140745" name="WNT5A-dependent internalization of FZD2, FZD5 and ROR2"/>
            <pathway-xref db="Reactome" id="R-DRE-190322" name="FGFR4 ligand binding and activation"/>
            <pathway-xref db="MetaCyc" id="PWY-7463" name="N-methylanthraniloyl-beta-D-glucopyranose biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-975634" name="Retinoid metabolism and transport"/>
            <pathway-xref db="MetaCyc" id="PWY-7166" name="kaempferide triglycoside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-8865999" name="MET activates PTPN11"/>
            <pathway-xref db="Reactome" id="R-HSA-9664323" name="FCGR3A-mediated IL10 synthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-5635838" name="Activation of SMO"/>
            <pathway-xref db="Reactome" id="R-HSA-9702620" name="quizartinib-resistant FLT3 mutants"/>
            <pathway-xref db="Reactome" id="R-HSA-1300645" name="Acrosome Reaction and Sperm:Oocyte Membrane Binding"/>
            <pathway-xref db="Reactome" id="R-RNO-2022870" name="Chondroitin sulfate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-6809371" name="Formation of the cornified envelope"/>
            <pathway-xref db="Reactome" id="R-MMU-5660668" name="CLEC7A/inflammasome pathway"/>
            <pathway-xref db="Reactome" id="R-HSA-9603381" name="Activated NTRK3 signals through PI3K"/>
            <pathway-xref db="Reactome" id="R-HSA-5684264" name="MAP3K8 (TPL2)-dependent MAPK1/3 activation"/>
            <pathway-xref db="Reactome" id="R-DRE-190372" name="FGFR3c ligand binding and activation"/>
            <pathway-xref db="MetaCyc" id="PWY-7706" name="dapdiamides biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7318" name="dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6906" name="chitin derivatives degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-5654227" name="Phospholipase C-mediated cascade, FGFR3"/>
            <pathway-xref db="Reactome" id="R-MMU-9696273" name="RND1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-110056" name="MAPK3 (ERK1) activation"/>
            <pathway-xref db="Reactome" id="R-MMU-372708" name="p130Cas linkage to MAPK signaling for integrins"/>
            <pathway-xref db="MetaCyc" id="PWY-1981" name="indole-3-acetate inactivation III"/>
            <pathway-xref db="Reactome" id="R-DRE-5654700" name="FRS-mediated FGFR2 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-6785807" name="Interleukin-4 and Interleukin-13 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-8964046" name="VLDL clearance"/>
            <pathway-xref db="MetaCyc" id="PWY-7979" name="protein O-mannosylation III (mammals, core M3)"/>
            <pathway-xref db="Reactome" id="R-HSA-9013423" name="RAC3 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-6310" name="aloesone biosynthesis II"/>
            <pathway-xref db="Reactome" id="R-HSA-389359" name="CD28 dependent Vav1 pathway"/>
            <pathway-xref db="MetaCyc" id="PWY-7191" name="kaempferol diglycoside biosynthesis (pollen-specific)"/>
            <pathway-xref db="Reactome" id="R-HSA-9013420" name="RHOU GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-7815" name="poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)"/>
            <pathway-xref db="Reactome" id="R-HSA-212676" name="Dopamine Neurotransmitter Release Cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-842" name="starch degradation I"/>
            <pathway-xref db="Reactome" id="R-RNO-416476" name="G alpha (q) signalling events"/>
            <pathway-xref db="Reactome" id="R-RNO-8874081" name="MET activates PTK2 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-7129" name="quercetin glucoside biosynthesis (Allium)"/>
            <pathway-xref db="Reactome" id="R-HSA-9020702" name="Interleukin-1 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9013508" name="NOTCH3 Intracellular Domain Regulates Transcription"/>
            <pathway-xref db="Reactome" id="R-MMU-193634" name="Axonal growth inhibition (RHOA activation)"/>
            <pathway-xref db="Reactome" id="R-MMU-1462054" name="Alpha-defensins"/>
            <pathway-xref db="Reactome" id="R-BTA-388841" name="Costimulation by the CD28 family"/>
            <pathway-xref db="Reactome" id="R-HSA-9674428" name="PDGFR mutants bind TKIs"/>
            <pathway-xref db="MetaCyc" id="PWY-5466" name="matairesinol biosynthesis"/>
            <pathway-xref db="Reactome" id="R-GGA-373920" name="Pyruvate metabolism"/>
            <pathway-xref db="Reactome" id="R-DME-110478" name="Insulin signaling pathway"/>
            <pathway-xref db="Reactome" id="R-HSA-8983432" name="Interleukin-15 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-7382" name="lipoate biosynthesis and incorporation IV (yeast)"/>
            <pathway-xref db="Reactome" id="R-BTA-5628897" name="TP53 Regulates Metabolic Genes"/>
            <pathway-xref db="Reactome" id="R-MMU-190377" name="FGFR2b ligand binding and activation"/>
            <pathway-xref db="MetaCyc" id="PWY-7583" name="arachidonate biosynthesis II (bacteria)"/>
            <pathway-xref db="Reactome" id="R-RNO-933542" name="TRAF6 mediated NF-kB activation"/>
            <pathway-xref db="Reactome" id="R-MMU-163680" name="AMPK inhibits chREBP transcriptional activation activity"/>
            <pathway-xref db="MetaCyc" id="PWY-7460" name="2-O-acetyl-3-O-trans-coutarate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5310" name="superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)"/>
            <pathway-xref db="Reactome" id="R-SCE-163680" name="AMPK inhibits chREBP transcriptional activation activity"/>
            <pathway-xref db="Reactome" id="R-MMU-2871796" name="FCERI mediated MAPK activation"/>
            <pathway-xref db="Reactome" id="R-HSA-9032759" name="NTRK2 activates RAC1"/>
            <pathway-xref db="Reactome" id="R-HSA-1236977" name="Endosomal/Vacuolar pathway"/>
            <pathway-xref db="Reactome" id="R-HSA-9013405" name="RHOD GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-8857538" name="PTK6 promotes HIF1A stabilization"/>
            <pathway-xref db="Reactome" id="R-HSA-9669934" name="Sunitinib-resistant KIT mutants"/>
            <pathway-xref db="Reactome" id="R-MMU-418990" name="Adherens junctions interactions"/>
            <pathway-xref db="Reactome" id="R-CEL-416572" name="Sema4D induced cell migration and growth-cone collapse"/>
            <pathway-xref db="Reactome" id="R-RNO-9014826" name="Interleukin-36 pathway"/>
            <pathway-xref db="Reactome" id="R-MMU-4420097" name="VEGFA-VEGFR2 Pathway"/>
            <pathway-xref db="Reactome" id="R-DRE-449836" name="Other interleukin signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-193648" name="NRAGE signals death through JNK"/>
            <pathway-xref db="Reactome" id="R-HSA-3656225" name="Defective CHST6 causes MCDC1"/>
            <pathway-xref db="Reactome" id="R-GGA-5173105" name="O-linked glycosylation"/>
            <pathway-xref db="Reactome" id="R-MMU-389356" name="CD28 co-stimulation"/>
            <pathway-xref db="Reactome" id="R-CFA-2024096" name="HS-GAG degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-2871796" name="FCERI mediated MAPK activation"/>
            <pathway-xref db="Reactome" id="R-HSA-445095" name="Interaction between L1 and Ankyrins"/>
            <pathway-xref db="MetaCyc" id="PWY-7820" name="teichuronic acid biosynthesis (B. subtilis 168)"/>
            <pathway-xref db="Reactome" id="R-MMU-1660514" name="Synthesis of PIPs at the Golgi membrane"/>
            <pathway-xref db="Reactome" id="R-MMU-187042" name="TRKA activation by NGF"/>
            <pathway-xref db="Reactome" id="R-HSA-8857538" name="PTK6 promotes HIF1A stabilization"/>
            <pathway-xref db="MetaCyc" id="PWY-81" name="toluene degradation to benzoyl-CoA (anaerobic)"/>
            <pathway-xref db="Reactome" id="R-HSA-1855204" name="Synthesis of IP3 and IP4 in the cytosol"/>
            <pathway-xref db="MetaCyc" id="PWY-5835" name="geranyl acetate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-2022870" name="Chondroitin sulfate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CFA-193692" name="Regulated proteolysis of p75NTR"/>
            <pathway-xref db="Reactome" id="R-HSA-2023837" name="Signaling by FGFR2 amplification mutants"/>
            <pathway-xref db="Reactome" id="R-HSA-9674404" name="Sorafenib-resistant PDGFR mutants"/>
            <pathway-xref db="MetaCyc" id="PWY-8219" name="Escherichia coli serotype O:107 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-181429" name="Serotonin Neurotransmitter Release Cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-5397" name="crocetin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7671" name="saframycin A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-9007892" name="Interleukin-38 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-5083629" name="Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2"/>
            <pathway-xref db="MetaCyc" id="PWY-7693" name="guadinomine B biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-372708" name="p130Cas linkage to MAPK signaling for integrins"/>
            <pathway-xref db="Reactome" id="R-HSA-5658623" name="FGFRL1 modulation of FGFR1 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-9027276" name="Erythropoietin activates Phosphoinositide-3-kinase (PI3K)"/>
            <pathway-xref db="Reactome" id="R-SSC-1236977" name="Endosomal/Vacuolar pathway"/>
            <pathway-xref db="Reactome" id="R-RNO-373760" name="L1CAM interactions"/>
            <pathway-xref db="MetaCyc" id="PWY-7071" name="steviol glucoside biosynthesis (rebaudioside A biosynthesis)"/>
            <pathway-xref db="MetaCyc" id="PWY-7989" name="acinetoferrin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-5654726" name="Negative regulation of FGFR1 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9032500" name="Activated NTRK2 signals through FYN"/>
            <pathway-xref db="Reactome" id="R-DME-5654228" name="Phospholipase C-mediated cascade, FGFR4"/>
            <pathway-xref db="Reactome" id="R-HSA-9674403" name="Regorafenib-resistant PDGFR mutants"/>
            <pathway-xref db="Reactome" id="R-MMU-173736" name="Alternative complement activation"/>
            <pathway-xref db="Reactome" id="R-HSA-202427" name="Phosphorylation of CD3 and TCR zeta chains"/>
            <pathway-xref db="Reactome" id="R-SSC-9013405" name="RHOD GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-8248" name="lipid A-core biosynthesis (P. gingivalis)"/>
            <pathway-xref db="Reactome" id="R-HSA-9669921" name="KIT mutants bind TKIs"/>
            <pathway-xref db="Reactome" id="R-RNO-3928665" name="EPH-ephrin mediated repulsion of cells"/>
            <pathway-xref db="Reactome" id="R-HSA-5689603" name="UCH proteinases"/>
            <pathway-xref db="Reactome" id="R-HSA-376172" name="DSCAM interactions"/>
            <pathway-xref db="Reactome" id="R-DME-202424" name="Downstream TCR signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-3878781" name="Glycogen storage disease type IV (GBE1)"/>
            <pathway-xref db="Reactome" id="R-HSA-9028335" name="Activated NTRK2 signals through PI3K"/>
            <pathway-xref db="Reactome" id="R-MMU-3000170" name="Syndecan interactions"/>
            <pathway-xref db="Reactome" id="R-RNO-5576892" name="Phase 0 - rapid depolarisation"/>
            <pathway-xref db="Reactome" id="R-DME-190322" name="FGFR4 ligand binding and activation"/>
            <pathway-xref db="MetaCyc" id="PWY-6558" name="heparan sulfate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-75892" name="Platelet Adhesion to exposed collagen"/>
            <pathway-xref db="MetaCyc" id="PWY-5976" name="dhurrin degradation"/>
            <pathway-xref db="Reactome" id="R-GGA-1474228" name="Degradation of the extracellular matrix"/>
            <pathway-xref db="Reactome" id="R-HSA-5654726" name="Negative regulation of FGFR1 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-195399" name="VEGF binds to VEGFR leading to receptor dimerization"/>
            <pathway-xref db="Reactome" id="R-HSA-166058" name="MyD88:MAL(TIRAP) cascade initiated on plasma membrane"/>
            <pathway-xref db="Reactome" id="R-MMU-173623" name="Classical antibody-mediated complement activation"/>
            <pathway-xref db="MetaCyc" id="PWY-8038" name="naphthomycin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7055" name="daphnetin modification"/>
            <pathway-xref db="MetaCyc" id="PWY-7737" name="thiocoraline biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5759" name="saponin biosynthesis III"/>
            <pathway-xref db="MetaCyc" id="PWY-7458" name="violdelphin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-1059683" name="Interleukin-6 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-7672" name="fusaric acid biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7529" name="CMP-N-acetyl-7-O-acetylneuraminate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-5654712" name="FRS-mediated FGFR4 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-196108" name="Pregnenolone biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-74752" name="Signaling by Insulin receptor"/>
            <pathway-xref db="Reactome" id="R-DRE-3928665" name="EPH-ephrin mediated repulsion of cells"/>
            <pathway-xref db="MetaCyc" id="PWY-6362" name="1D-myo-inositol hexakisphosphate biosynthesis II (mammalian)"/>
            <pathway-xref db="Reactome" id="R-MMU-418889" name="Caspase activation via Dependence Receptors in the absence of ligand"/>
            <pathway-xref db="Reactome" id="R-MMU-375276" name="Peptide ligand-binding receptors"/>
            <pathway-xref db="Reactome" id="R-DME-5654700" name="FRS-mediated FGFR2 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9702509" name="FLT3 mutants bind TKIs"/>
            <pathway-xref db="Reactome" id="R-MMU-9020956" name="Interleukin-27 signaling"/>
            <pathway-xref db="Reactome" id="R-GGA-434131" name="NFkB activation mediated by RIP1 complexed with activated TLR3"/>
            <pathway-xref db="Reactome" id="R-MMU-202430" name="Translocation of ZAP-70 to Immunological synapse"/>
            <pathway-xref db="Reactome" id="R-HSA-9013409" name="RHOJ GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-432142" name="Platelet sensitization by LDL"/>
            <pathway-xref db="Reactome" id="R-HSA-9020956" name="Interleukin-27 signaling"/>
            <pathway-xref db="Reactome" id="R-SSC-2024096" name="HS-GAG degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-8075" name="(Kdo)2-lipid A biosynthesis (P. putida)"/>
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            <pathway-xref db="Reactome" id="R-RNO-879415" name="Advanced glycosylation endproduct receptor signaling"/>
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            <pathway-xref db="Reactome" id="R-BTA-1660661" name="Sphingolipid de novo biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-RNO-354192" name="Integrin signaling"/>
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            <pathway-xref db="MetaCyc" id="PWY-7172" name="flavonol acylglucoside biosynthesis III - quercetin derivatives"/>
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            <pathway-xref db="MetaCyc" id="PWY-7192" name="quercetin diglycoside biosynthesis (pollen-specific)"/>
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            <pathway-xref db="MetaCyc" id="PWY-7771" name="butachlor degradation"/>
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            <pathway-xref db="MetaCyc" id="PWY-6623" name="salicylate glucosides biosynthesis II"/>
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            <pathway-xref db="Reactome" id="R-MMU-264642" name="Acetylcholine Neurotransmitter Release Cycle"/>
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            <pathway-xref db="Reactome" id="R-HSA-196108" name="Pregnenolone biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-HSA-8983711" name="OAS antiviral response"/>
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            <pathway-xref db="Reactome" id="R-MMU-166665" name="Terminal pathway of complement"/>
            <pathway-xref db="MetaCyc" id="PWY-8047" name="bryostatin biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-6948" name="sitosterol degradation to androstenedione"/>
            <pathway-xref db="Reactome" id="R-DME-5654695" name="PI-3K cascade:FGFR2"/>
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            <pathway-xref db="Reactome" id="R-MMU-447043" name="Neurofascin interactions"/>
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            <pathway-xref db="MetaCyc" id="PWY-5846" name="colchicine biosynthesis"/>
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          </panther-location>
        </locations>
      </panther-match>
      <panther-match evalue="7.0E-132" familyName="PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ROS" score="453.3">
        <signature ac="PTHR24416:SF527" name="PROTO-ONCOGENE TYROSINE-PROTEIN KINASE ROS">
          <signature-library-release library="PANTHER" version="15.0"/>
        </signature>
        <model-ac>PTHR24416:SF527</model-ac>
        <locations>
          <panther-location env-start="915" env-end="1209" hmm-start="1952" hmm-end="2230" hmm-length="2341" hmm-bounds="INCOMPLETE" start="927" end="1201">
            <location-fragments>
              <panther-location-fragment start="927" end="1201" dc-status="CONTINUOUS"/>
            </location-fragments>
          </panther-location>
        </locations>
      </panther-match>
      <patternscan-match>
        <signature ac="PS00239" desc="Receptor tyrosine kinase class II signature." name="RECEPTOR_TYR_KIN_II">
          <entry ac="IPR002011" desc="Tyrosine-protein kinase, receptor class II, conserved site" name="Tyr_kinase_rcpt_2_CS" type="CONSERVED_SITE">
            <go-xref category="MOLECULAR_FUNCTION" db="GO" id="GO:0004714" name="transmembrane receptor protein tyrosine kinase activity"/>
            <go-xref category="CELLULAR_COMPONENT" db="GO" id="GO:0016020" name="membrane"/>
            <go-xref category="BIOLOGICAL_PROCESS" db="GO" id="GO:0007169" name="transmembrane receptor protein tyrosine kinase signaling pathway"/>
            <go-xref category="MOLECULAR_FUNCTION" db="GO" id="GO:0005524" name="ATP binding"/>
            <go-xref category="BIOLOGICAL_PROCESS" db="GO" id="GO:0006468" name="protein phosphorylation"/>
            <pathway-xref db="Reactome" id="R-HSA-187024" name="NGF-independant TRKA activation"/>
            <pathway-xref db="Reactome" id="R-HSA-74752" name="Signaling by Insulin receptor"/>
            <pathway-xref db="Reactome" id="R-HSA-74749" name="Signal attenuation"/>
            <pathway-xref db="Reactome" id="R-RNO-9034793" name="Activated NTRK3 signals through PLCG1"/>
            <pathway-xref db="Reactome" id="R-HSA-388844" name="Receptor-type tyrosine-protein phosphatases"/>
            <pathway-xref db="Reactome" id="R-HSA-9034015" name="Signaling by NTRK3 (TRKC)"/>
            <pathway-xref db="Reactome" id="R-RNO-187042" name="TRKA activation by NGF"/>
            <pathway-xref db="Reactome" id="R-RNO-170968" name="Frs2-mediated activation"/>
            <pathway-xref db="Reactome" id="R-MMU-9009391" name="Extra-nuclear estrogen signaling"/>
            <pathway-xref db="Reactome" id="R-DME-110478" name="Insulin signaling pathway"/>
            <pathway-xref db="Reactome" id="R-MMU-198203" name="PI3K/AKT activation"/>
            <pathway-xref db="Reactome" id="R-GGA-9028731" name="Activated NTRK2 signals through FRS2 and FRS3"/>
            <pathway-xref db="Reactome" id="R-RNO-74713" name="IRS activation"/>
            <pathway-xref db="Reactome" id="R-MMU-6811558" name="PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-187042" name="TRKA activation by NGF"/>
            <pathway-xref db="Reactome" id="R-RNO-9034013" name="NTF3 activates NTRK3 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9009391" name="Extra-nuclear estrogen signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-9028731" name="Activated NTRK2 signals through FRS2 and FRS3"/>
            <pathway-xref db="Reactome" id="R-DME-5140745" name="WNT5A-dependent internalization of FZD2, FZD5 and ROR2"/>
            <pathway-xref db="Reactome" id="R-HSA-9034864" name="Activated NTRK3 signals through RAS"/>
            <pathway-xref db="Reactome" id="R-MMU-74713" name="IRS activation"/>
            <pathway-xref db="Reactome" id="R-HSA-170968" name="Frs2-mediated activation"/>
            <pathway-xref db="Reactome" id="R-RNO-2428928" name="IRS-related events triggered by IGF1R"/>
            <pathway-xref db="Reactome" id="R-RNO-74752" name="Signaling by Insulin receptor"/>
            <pathway-xref db="Reactome" id="R-MMU-77387" name="Insulin receptor recycling"/>
            <pathway-xref db="Reactome" id="R-RNO-170984" name="ARMS-mediated activation"/>
            <pathway-xref db="Reactome" id="R-HSA-9026519" name="Activated NTRK2 signals through RAS"/>
            <pathway-xref db="Reactome" id="R-HSA-77387" name="Insulin receptor recycling"/>
            <pathway-xref db="Reactome" id="R-MMU-9026527" name="Activated NTRK2 signals through PLCG1"/>
            <pathway-xref db="Reactome" id="R-HSA-9032759" name="NTRK2 activates RAC1"/>
            <pathway-xref db="Reactome" id="R-MMU-3000171" name="Non-integrin membrane-ECM interactions"/>
            <pathway-xref db="Reactome" id="R-MMU-9034013" name="NTF3 activates NTRK3 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-2428928" name="IRS-related events triggered by IGF1R"/>
            <pathway-xref db="Reactome" id="R-HSA-9028335" name="Activated NTRK2 signals through PI3K"/>
            <pathway-xref db="Reactome" id="R-HSA-170984" name="ARMS-mediated activation"/>
            <pathway-xref db="Reactome" id="R-DME-9009391" name="Extra-nuclear estrogen signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-2404192" name="Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)"/>
            <pathway-xref db="Reactome" id="R-HSA-9024909" name="BDNF activates NTRK2 (TRKB) signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-74751" name="Insulin receptor signalling cascade"/>
            <pathway-xref db="Reactome" id="R-RNO-2404192" name="Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)"/>
            <pathway-xref db="Reactome" id="R-HSA-187706" name="Signalling to p38 via RIT and RIN"/>
            <pathway-xref db="Reactome" id="R-MMU-2428933" name="SHC-related events triggered by IGF1R"/>
            <pathway-xref db="Reactome" id="R-DME-77387" name="Insulin receptor recycling"/>
            <pathway-xref db="Reactome" id="R-HSA-9026357" name="NTF4 activates NTRK2 (TRKB) signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-198203" name="PI3K/AKT activation"/>
            <pathway-xref db="Reactome" id="R-MMU-9034793" name="Activated NTRK3 signals through PLCG1"/>
            <pathway-xref db="Reactome" id="R-MMU-74752" name="Signaling by Insulin receptor"/>
            <pathway-xref db="Reactome" id="R-MMU-2404192" name="Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)"/>
            <pathway-xref db="Reactome" id="R-HSA-9025046" name="NTF3 activates NTRK2 (TRKB) signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9032845" name="Activated NTRK2 signals through CDK5"/>
            <pathway-xref db="Reactome" id="R-MMU-177504" name="Retrograde neurotrophin signalling"/>
            <pathway-xref db="Reactome" id="R-HSA-9034793" name="Activated NTRK3 signals through PLCG1"/>
            <pathway-xref db="Reactome" id="R-GGA-9032759" name="NTRK2 activates RAC1"/>
            <pathway-xref db="Reactome" id="R-RNO-2428933" name="SHC-related events triggered by IGF1R"/>
            <pathway-xref db="Reactome" id="R-MMU-9603381" name="Activated NTRK3 signals through PI3K"/>
            <pathway-xref db="Reactome" id="R-HSA-74713" name="IRS activation"/>
            <pathway-xref db="Reactome" id="R-MMU-9028731" name="Activated NTRK2 signals through FRS2 and FRS3"/>
            <pathway-xref db="Reactome" id="R-HSA-198203" name="PI3K/AKT activation"/>
            <pathway-xref db="Reactome" id="R-HSA-2428928" name="IRS-related events triggered by IGF1R"/>
            <pathway-xref db="Reactome" id="R-RNO-9032759" name="NTRK2 activates RAC1"/>
            <pathway-xref db="Reactome" id="R-HSA-9603381" name="Activated NTRK3 signals through PI3K"/>
            <pathway-xref db="Reactome" id="R-GGA-388844" name="Receptor-type tyrosine-protein phosphatases"/>
            <pathway-xref db="Reactome" id="R-HSA-9034013" name="NTF3 activates NTRK3 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9028731" name="Activated NTRK2 signals through FRS2 and FRS3"/>
            <pathway-xref db="Reactome" id="R-RNO-77387" name="Insulin receptor recycling"/>
            <pathway-xref db="Reactome" id="R-MMU-388844" name="Receptor-type tyrosine-protein phosphatases"/>
            <pathway-xref db="Reactome" id="R-MMU-74749" name="Signal attenuation"/>
            <pathway-xref db="Reactome" id="R-RNO-3000171" name="Non-integrin membrane-ECM interactions"/>
            <pathway-xref db="Reactome" id="R-RNO-9009391" name="Extra-nuclear estrogen signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-198745" name="Signalling to STAT3"/>
            <pathway-xref db="Reactome" id="R-HSA-3000171" name="Non-integrin membrane-ECM interactions"/>
            <pathway-xref db="Reactome" id="R-RNO-74749" name="Signal attenuation"/>
            <pathway-xref db="Reactome" id="R-RNO-388844" name="Receptor-type tyrosine-protein phosphatases"/>
            <pathway-xref db="Reactome" id="R-RNO-177504" name="Retrograde neurotrophin signalling"/>
            <pathway-xref db="Reactome" id="R-RNO-9603381" name="Activated NTRK3 signals through PI3K"/>
            <pathway-xref db="Reactome" id="R-HSA-6811558" name="PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-167044" name="Signalling to RAS"/>
            <pathway-xref db="Reactome" id="R-HSA-74751" name="Insulin receptor signalling cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-2428933" name="SHC-related events triggered by IGF1R"/>
            <pathway-xref db="Reactome" id="R-MMU-170984" name="ARMS-mediated activation"/>
            <pathway-xref db="Reactome" id="R-HSA-9026527" name="Activated NTRK2 signals through PLCG1"/>
            <pathway-xref db="Reactome" id="R-MMU-9032759" name="NTRK2 activates RAC1"/>
            <pathway-xref db="Reactome" id="R-RNO-9026527" name="Activated NTRK2 signals through PLCG1"/>
            <pathway-xref db="Reactome" id="R-HSA-177504" name="Retrograde neurotrophin signalling"/>
            <pathway-xref db="Reactome" id="R-MMU-74751" name="Insulin receptor signalling cascade"/>
            <pathway-xref db="Reactome" id="R-MMU-170968" name="Frs2-mediated activation"/>
            <pathway-xref db="Reactome" id="R-HSA-167021" name="PLC-gamma1 signalling"/>
            <pathway-xref db="Reactome" id="R-RNO-6811558" name="PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9032500" name="Activated NTRK2 signals through FYN"/>
            <pathway-xref db="Reactome" id="R-MMU-187042" name="TRKA activation by NGF"/>
            <pathway-xref db="Reactome" id="R-HSA-9603505" name="NTRK3 as a dependence receptor"/>
            <pathway-xref db="Reactome" id="R-GGA-9026527" name="Activated NTRK2 signals through PLCG1"/>
          </entry>
          <signature-library-release library="PROSITE_PATTERNS" version="2021_01"/>
        </signature>
        <model-ac>PS00239</model-ac>
        <locations>
          <patternscan-location level="STRONG" start="1089" end="1097">
            <location-fragments>
              <patternscan-location-fragment start="1089" end="1097" dc-status="CONTINUOUS"/>
            </location-fragments>
            <alignment>DIYkdhYYR</alignment>
          </patternscan-location>
        </locations>
      </patternscan-match>
      <patternscan-match>
        <signature ac="PS00109" desc="Tyrosine protein kinases specific active-site signature." name="PROTEIN_KINASE_TYR">
          <entry ac="IPR008266" desc="Tyrosine-protein kinase, active site" name="Tyr_kinase_AS" type="ACTIVE_SITE">
            <go-xref category="MOLECULAR_FUNCTION" db="GO" id="GO:0004672" name="protein kinase activity"/>
            <go-xref category="BIOLOGICAL_PROCESS" db="GO" id="GO:0006468" name="protein phosphorylation"/>
            <pathway-xref db="Reactome" id="R-SSC-389357" name="CD28 dependent PI3K/Akt signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-74749" name="Signal attenuation"/>
            <pathway-xref db="Reactome" id="R-DRE-418885" name="DCC mediated attractive signaling"/>
            <pathway-xref db="Reactome" id="R-BTA-389356" name="CD28 co-stimulation"/>
            <pathway-xref db="Reactome" id="R-HSA-202733" name="Cell surface interactions at the vascular wall"/>
            <pathway-xref db="Reactome" id="R-DME-399954" name="Sema3A PAK dependent Axon repulsion"/>
            <pathway-xref db="Reactome" id="R-DME-110478" name="Insulin signaling pathway"/>
            <pathway-xref db="Reactome" id="R-HSA-9610379" name="HCMV Late Events"/>
            <pathway-xref db="Reactome" id="R-HSA-8983432" name="Interleukin-15 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-2565942" name="Regulation of PLK1 Activity at G2/M Transition"/>
            <pathway-xref db="Reactome" id="R-HSA-5673001" name="RAF/MAP kinase cascade"/>
            <pathway-xref db="Reactome" id="R-GGA-3928665" name="EPH-ephrin mediated repulsion of cells"/>
            <pathway-xref db="Reactome" id="R-MMU-8983432" name="Interleukin-15 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9013507" name="NOTCH3 Activation and Transmission of Signal to the Nucleus"/>
            <pathway-xref db="Reactome" id="R-HSA-187042" name="TRKA activation by NGF"/>
            <pathway-xref db="Reactome" id="R-MMU-5620912" name="Anchoring of the basal body to the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-MMU-2565942" name="Regulation of PLK1 Activity at G2/M Transition"/>
            <pathway-xref db="Reactome" id="R-MMU-190377" name="FGFR2b ligand binding and activation"/>
            <pathway-xref db="Reactome" id="R-DRE-372708" name="p130Cas linkage to MAPK signaling for integrins"/>
            <pathway-xref db="Reactome" id="R-CEL-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-HSA-5620912" name="Anchoring of the basal body to the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-RNO-2428928" name="IRS-related events triggered by IGF1R"/>
            <pathway-xref db="Reactome" id="R-MMU-9013507" name="NOTCH3 Activation and Transmission of Signal to the Nucleus"/>
            <pathway-xref db="Reactome" id="R-HSA-389948" name="PD-1 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9702596" name="lestaurtinib-resistant FLT3 mutants"/>
            <pathway-xref db="Reactome" id="R-HSA-9702569" name="KW2449-resistant FLT3 mutants"/>
            <pathway-xref db="Reactome" id="R-MMU-5674135" name="MAP2K and MAPK activation"/>
            <pathway-xref db="Reactome" id="R-HSA-6807004" name="Negative regulation of MET activity"/>
            <pathway-xref db="Reactome" id="R-RNO-5621575" name="CD209 (DC-SIGN) signaling"/>
            <pathway-xref db="Reactome" id="R-DRE-6788467" name="IL-6-type cytokine receptor ligand interactions"/>
            <pathway-xref db="Reactome" id="R-CEL-9013407" name="RHOH GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-877300" name="Interferon gamma signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9032759" name="NTRK2 activates RAC1"/>
            <pathway-xref db="Reactome" id="R-MMU-2871796" name="FCERI mediated MAPK activation"/>
            <pathway-xref db="Reactome" id="R-HSA-877300" name="Interferon gamma signaling"/>
            <pathway-xref db="Reactome" id="R-DRE-5663220" name="RHO GTPases Activate Formins"/>
            <pathway-xref db="Reactome" id="R-DME-177929" name="Signaling by EGFR"/>
            <pathway-xref db="Reactome" id="R-HSA-9703009" name="tamatinib-resistant FLT3 mutants"/>
            <pathway-xref db="Reactome" id="R-MMU-2454202" name="Fc epsilon receptor (FCERI) signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-354194" name="GRB2:SOS provides linkage to MAPK signaling for Integrins"/>
            <pathway-xref db="Reactome" id="R-CEL-180292" name="GAB1 signalosome"/>
            <pathway-xref db="Reactome" id="R-MMU-8863795" name="Downregulation of ERBB2 signaling"/>
            <pathway-xref db="Reactome" id="R-DME-3928662" name="EPHB-mediated forward signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-75892" name="Platelet Adhesion to exposed collagen"/>
            <pathway-xref db="Reactome" id="R-MMU-8857538" name="PTK6 promotes HIF1A stabilization"/>
            <pathway-xref db="Reactome" id="R-DRE-1433557" name="Signaling by SCF-KIT"/>
            <pathway-xref db="Reactome" id="R-RNO-380270" name="Recruitment of mitotic centrosome proteins and complexes"/>
            <pathway-xref db="Reactome" id="R-HSA-9649948" name="Signaling downstream of RAS mutants"/>
            <pathway-xref db="Reactome" id="R-MMU-8874081" name="MET activates PTK2 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9669934" name="Sunitinib-resistant KIT mutants"/>
            <pathway-xref db="Reactome" id="R-HSA-9620244" name="Long-term potentiation"/>
            <pathway-xref db="Reactome" id="R-CEL-416572" name="Sema4D induced cell migration and growth-cone collapse"/>
            <pathway-xref db="Reactome" id="R-MMU-202733" name="Cell surface interactions at the vascular wall"/>
            <pathway-xref db="Reactome" id="R-MMU-389948" name="PD-1 signaling"/>
            <pathway-xref db="Reactome" id="R-DME-1295596" name="Spry regulation of FGF signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-4420097" name="VEGFA-VEGFR2 Pathway"/>
            <pathway-xref db="Reactome" id="R-DRE-9705462" name="Inactivation of CSF3 (G-CSF) signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-5693565" name="Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"/>
            <pathway-xref db="Reactome" id="R-SSC-3928663" name="EPHA-mediated growth cone collapse"/>
            <pathway-xref db="Reactome" id="R-DRE-449836" name="Other interleukin signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-193648" name="NRAGE signals death through JNK"/>
            <pathway-xref db="Reactome" id="R-CEL-8948751" name="Regulation of PTEN stability and activity"/>
            <pathway-xref db="Reactome" id="R-HSA-4420097" name="VEGFA-VEGFR2 Pathway"/>
            <pathway-xref db="Reactome" id="R-RNO-190373" name="FGFR1c ligand binding and activation"/>
            <pathway-xref db="Reactome" id="R-DME-399955" name="SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion"/>
            <pathway-xref db="Reactome" id="R-DRE-9674555" name="Signaling by CSF3 (G-CSF)"/>
            <pathway-xref db="Reactome" id="R-CEL-1433557" name="Signaling by SCF-KIT"/>
            <pathway-xref db="Reactome" id="R-CEL-182971" name="EGFR downregulation"/>
            <pathway-xref db="Reactome" id="R-HSA-8853336" name="Signaling by plasma membrane FGFR1 fusions"/>
            <pathway-xref db="Reactome" id="R-MMU-389356" name="CD28 co-stimulation"/>
            <pathway-xref db="Reactome" id="R-HSA-1839122" name="Signaling by activated point mutants of FGFR1"/>
            <pathway-xref db="Reactome" id="R-RNO-3000171" name="Non-integrin membrane-ECM interactions"/>
            <pathway-xref db="Reactome" id="R-DME-179812" name="GRB2 events in EGFR signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-8875360" name="InlB-mediated entry of Listeria monocytogenes into host cell"/>
            <pathway-xref db="Reactome" id="R-HSA-8940973" name="RUNX2 regulates osteoblast differentiation"/>
            <pathway-xref db="Reactome" id="R-MMU-190375" name="FGFR2c ligand binding and activation"/>
            <pathway-xref db="Reactome" id="R-DME-190370" name="FGFR1b ligand binding and activation"/>
            <pathway-xref db="Reactome" id="R-HSA-2454202" name="Fc epsilon receptor (FCERI) signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-2871796" name="FCERI mediated MAPK activation"/>
            <pathway-xref db="Reactome" id="R-HSA-8863795" name="Downregulation of ERBB2 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-75892" name="Platelet Adhesion to exposed collagen"/>
            <pathway-xref db="Reactome" id="R-CFA-1433557" name="Signaling by SCF-KIT"/>
            <pathway-xref db="Reactome" id="R-HSA-389356" name="CD28 co-stimulation"/>
            <pathway-xref db="Reactome" id="R-HSA-167044" name="Signalling to RAS"/>
            <pathway-xref db="Reactome" id="R-HSA-5674135" name="MAP2K and MAPK activation"/>
            <pathway-xref db="Reactome" id="R-RNO-5690714" name="CD22 mediated BCR regulation"/>
            <pathway-xref db="Reactome" id="R-MMU-9013408" name="RHOG GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-1963640" name="GRB2 events in ERBB2 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-8847993" name="ERBB2 Activates PTK6 Signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-1963642" name="PI3K events in ERBB2 signaling"/>
            <pathway-xref db="Reactome" id="R-GGA-1253288" name="Downregulation of ERBB4 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-190377" name="FGFR2b ligand binding and activation"/>
            <pathway-xref db="Reactome" id="R-DRE-5621480" name="Dectin-2 family"/>
            <pathway-xref db="Reactome" id="R-MMU-6807004" name="Negative regulation of MET activity"/>
            <pathway-xref db="Reactome" id="R-HSA-9603505" name="NTRK3 as a dependence receptor"/>
            <pathway-xref db="Reactome" id="R-MMU-187042" name="TRKA activation by NGF"/>
            <pathway-xref db="Reactome" id="R-HSA-8857538" name="PTK6 promotes HIF1A stabilization"/>
            <pathway-xref db="Reactome" id="R-DME-2179392" name="EGFR Transactivation by Gastrin"/>
            <pathway-xref db="Reactome" id="R-MMU-2871837" name="FCERI mediated NF-kB activation"/>
            <pathway-xref db="Reactome" id="R-DRE-912526" name="Interleukin receptor SHC signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-5654720" name="PI-3K cascade:FGFR4"/>
            <pathway-xref db="Reactome" id="R-RNO-9706374" name="FLT3 signaling through SRC family kinases"/>
            <pathway-xref db="Reactome" id="R-DME-111465" name="Apoptotic cleavage of cellular proteins"/>
            <pathway-xref db="Reactome" id="R-HSA-5654720" name="PI-3K cascade:FGFR4"/>
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            <pathway-xref db="Reactome" id="R-MMU-5673000" name="RAF activation"/>
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            <pathway-xref db="Reactome" id="R-RNO-2730905" name="Role of LAT2/NTAL/LAB on calcium mobilization"/>
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            <pathway-xref db="Reactome" id="R-GGA-2871809" name="FCERI mediated Ca+2 mobilization"/>
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            <pathway-xref db="Reactome" id="R-MMU-5654689" name="PI-3K cascade:FGFR1"/>
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            <pathway-xref db="Reactome" id="R-HSA-190370" name="FGFR1b ligand binding and activation"/>
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            <pathway-xref db="Reactome" id="R-DME-190377" name="FGFR2b ligand binding and activation"/>
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            <pathway-xref db="Reactome" id="R-BTA-389357" name="CD28 dependent PI3K/Akt signaling"/>
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            <pathway-xref db="Reactome" id="R-HSA-5654689" name="PI-3K cascade:FGFR1"/>
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            <pathway-xref db="Reactome" id="R-MMU-9013404" name="RAC2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DRE-8854691" name="Interleukin-20 family signaling"/>
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            <pathway-xref db="Reactome" id="R-HSA-216083" name="Integrin cell surface interactions"/>
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            <pathway-xref db="Reactome" id="R-BTA-3928663" name="EPHA-mediated growth cone collapse"/>
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            <pathway-xref db="Reactome" id="R-RNO-1250342" name="PI3K events in ERBB4 signaling"/>
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            <pathway-xref db="Reactome" id="R-DRE-6783783" name="Interleukin-10 signaling"/>
            <pathway-xref db="Reactome" id="R-DME-190375" name="FGFR2c ligand binding and activation"/>
            <pathway-xref db="Reactome" id="R-HSA-5654704" name="SHC-mediated cascade:FGFR3"/>
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            <pathway-xref db="Reactome" id="R-DRE-373753" name="Nephrin family interactions"/>
            <pathway-xref db="Reactome" id="R-MMU-354194" name="GRB2:SOS provides linkage to MAPK signaling for Integrins"/>
            <pathway-xref db="Reactome" id="R-DRE-1257604" name="PIP3 activates AKT signaling"/>
            <pathway-xref db="Reactome" id="R-DME-5654227" name="Phospholipase C-mediated cascade, FGFR3"/>
            <pathway-xref db="Reactome" id="R-MMU-9652282" name="Drug-mediated inhibition of ERBB2 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-1839128" name="FGFR4 mutant receptor activation"/>
            <pathway-xref db="Reactome" id="R-MMU-186763" name="Downstream signal transduction"/>
            <pathway-xref db="Reactome" id="R-CEL-5663213" name="RHO GTPases Activate WASPs and WAVEs"/>
            <pathway-xref db="Reactome" id="R-RNO-187042" name="TRKA activation by NGF"/>
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            <pathway-xref db="Reactome" id="R-HSA-380259" name="Loss of Nlp from mitotic centrosomes"/>
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            <pathway-xref db="Reactome" id="R-HSA-912526" name="Interleukin receptor SHC signaling"/>
            <pathway-xref db="Reactome" id="R-DME-6798695" name="Neutrophil degranulation"/>
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            <pathway-xref db="Reactome" id="R-DRE-5654720" name="PI-3K cascade:FGFR4"/>
            <pathway-xref db="Reactome" id="R-DRE-9009391" name="Extra-nuclear estrogen signaling"/>
            <pathway-xref db="Reactome" id="R-DME-5654688" name="SHC-mediated cascade:FGFR1"/>
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            <pathway-xref db="Reactome" id="R-HSA-5603041" name="IRAK4 deficiency (TLR2/4)"/>
            <pathway-xref db="Reactome" id="R-MMU-2029485" name="Role of phospholipids in phagocytosis"/>
            <pathway-xref db="Reactome" id="R-HSA-9674396" name="Imatinib-resistant PDGFR mutants"/>
            <pathway-xref db="Reactome" id="R-RNO-5674135" name="MAP2K and MAPK activation"/>
            <pathway-xref db="Reactome" id="R-HSA-418885" name="DCC mediated attractive signaling"/>
            <pathway-xref db="Reactome" id="R-DME-186763" name="Downstream signal transduction"/>
            <pathway-xref db="Reactome" id="R-HSA-74751" name="Insulin receptor signalling cascade"/>
            <pathway-xref db="Reactome" id="R-DME-8934903" name="Receptor Mediated Mitophagy"/>
            <pathway-xref db="Reactome" id="R-RNO-190322" name="FGFR4 ligand binding and activation"/>
            <pathway-xref db="Reactome" id="R-HSA-5690714" name="CD22 mediated BCR regulation"/>
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            <pathway-xref db="Reactome" id="R-MMU-1236394" name="Signaling by ERBB4"/>
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            <pathway-xref db="Reactome" id="R-MMU-9013149" name="RAC1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-190370" name="FGFR1b ligand binding and activation"/>
            <pathway-xref db="Reactome" id="R-DRE-5674135" name="MAP2K and MAPK activation"/>
            <pathway-xref db="Reactome" id="R-RNO-1358803" name="Downregulation of ERBB2:ERBB3 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-2033519" name="Activated point mutants of FGFR2"/>
            <pathway-xref db="Reactome" id="R-RNO-5621480" name="Dectin-2 family"/>
            <pathway-xref db="Reactome" id="R-DME-373753" name="Nephrin family interactions"/>
            <pathway-xref db="Reactome" id="R-GGA-2454202" name="Fc epsilon receptor (FCERI) signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-187577" name="SCF(Skp2)-mediated degradation of p27/p21"/>
            <pathway-xref db="Reactome" id="R-HSA-9702998" name="linifanib-resistant FLT3 mutants"/>
            <pathway-xref db="Reactome" id="R-HSA-9674401" name="Sunitinib-resistant PDGFR mutants"/>
            <pathway-xref db="Reactome" id="R-HSA-9674428" name="PDGFR mutants bind TKIs"/>
          </entry>
          <signature-library-release library="PROSITE_PATTERNS" version="2021_01"/>
        </signature>
        <model-ac>PS00109</model-ac>
        <locations>
          <patternscan-location level="STRONG" start="1057" end="1069">
            <location-fragments>
              <patternscan-location-fragment start="1057" end="1069" dc-status="CONTINUOUS"/>
            </location-fragments>
            <alignment>FVHkDLACRNCLI</alignment>
          </patternscan-location>
        </locations>
      </patternscan-match>
      <patternscan-match>
        <signature ac="PS00107" desc="Protein kinases ATP-binding region signature." name="PROTEIN_KINASE_ATP">
          <entry ac="IPR017441" desc="Protein kinase, ATP binding site" name="Protein_kinase_ATP_BS" type="BINDING_SITE">
            <go-xref category="MOLECULAR_FUNCTION" db="GO" id="GO:0005524" name="ATP binding"/>
            <pathway-xref db="Reactome" id="R-MMU-2173791" name="TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)"/>
            <pathway-xref db="Reactome" id="R-HSA-74749" name="Signal attenuation"/>
            <pathway-xref db="Reactome" id="R-DRE-418885" name="DCC mediated attractive signaling"/>
            <pathway-xref db="Reactome" id="R-BTA-389356" name="CD28 co-stimulation"/>
            <pathway-xref db="Reactome" id="R-CEL-6804116" name="TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest"/>
            <pathway-xref db="Reactome" id="R-HSA-202733" name="Cell surface interactions at the vascular wall"/>
            <pathway-xref db="Reactome" id="R-DME-399954" name="Sema3A PAK dependent Axon repulsion"/>
            <pathway-xref db="Reactome" id="R-CEL-69601" name="Ubiquitin Mediated Degradation of Phosphorylated Cdc25A"/>
            <pathway-xref db="Reactome" id="R-HSA-113418" name="Formation of the Early Elongation Complex"/>
            <pathway-xref db="Reactome" id="R-HSA-2565942" name="Regulation of PLK1 Activity at G2/M Transition"/>
            <pathway-xref db="Reactome" id="R-HSA-5673001" name="RAF/MAP kinase cascade"/>
            <pathway-xref db="Reactome" id="R-DME-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-DME-211163" name="AKT-mediated inactivation of FOXO1A"/>
            <pathway-xref db="Reactome" id="R-HSA-6791226" name="Major pathway of rRNA processing in the nucleolus and cytosol"/>
            <pathway-xref db="Reactome" id="R-HSA-187042" name="TRKA activation by NGF"/>
            <pathway-xref db="Reactome" id="R-MMU-5620912" name="Anchoring of the basal body to the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-CEL-171007" name="p38MAPK events"/>
            <pathway-xref db="Reactome" id="R-MMU-2565942" name="Regulation of PLK1 Activity at G2/M Transition"/>
            <pathway-xref db="Reactome" id="R-DRE-372708" name="p130Cas linkage to MAPK signaling for integrins"/>
            <pathway-xref db="Reactome" id="R-CEL-373752" name="Netrin-1 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-5620912" name="Anchoring of the basal body to the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-MMU-6791226" name="Major pathway of rRNA processing in the nucleolus and cytosol"/>
            <pathway-xref db="Reactome" id="R-DDI-198765" name="Signalling to ERK5"/>
            <pathway-xref db="Reactome" id="R-RNO-2428928" name="IRS-related events triggered by IGF1R"/>
            <pathway-xref db="Reactome" id="R-HSA-2559586" name="DNA Damage/Telomere Stress Induced Senescence"/>
            <pathway-xref db="Reactome" id="R-HSA-9702596" name="lestaurtinib-resistant FLT3 mutants"/>
            <pathway-xref db="Reactome" id="R-HSA-9702569" name="KW2449-resistant FLT3 mutants"/>
            <pathway-xref db="Reactome" id="R-RNO-5675221" name="Negative regulation of MAPK pathway"/>
            <pathway-xref db="Reactome" id="R-RNO-6804757" name="Regulation of TP53 Degradation"/>
            <pathway-xref db="Reactome" id="R-RNO-5621575" name="CD209 (DC-SIGN) signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-2559586" name="DNA Damage/Telomere Stress Induced Senescence"/>
            <pathway-xref db="Reactome" id="R-MMU-171319" name="Telomere Extension By Telomerase"/>
            <pathway-xref db="Reactome" id="R-MMU-877300" name="Interferon gamma signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-5693616" name="Presynaptic phase of homologous DNA pairing and strand exchange"/>
            <pathway-xref db="Reactome" id="R-CEL-9018519" name="Estrogen-dependent gene expression"/>
            <pathway-xref db="Reactome" id="R-HSA-9703009" name="tamatinib-resistant FLT3 mutants"/>
            <pathway-xref db="Reactome" id="R-MMU-2454202" name="Fc epsilon receptor (FCERI) signaling"/>
            <pathway-xref db="Reactome" id="R-DME-68911" name="G2 Phase"/>
            <pathway-xref db="Reactome" id="R-DME-4641262" name="Disassembly of the destruction complex and recruitment of AXIN to the membrane"/>
            <pathway-xref db="Reactome" id="R-CEL-180292" name="GAB1 signalosome"/>
            <pathway-xref db="Reactome" id="R-RNO-6796648" name="TP53 Regulates Transcription of DNA Repair Genes"/>
            <pathway-xref db="Reactome" id="R-MMU-1502540" name="Signaling by Activin"/>
            <pathway-xref db="Reactome" id="R-DME-209461" name="Ubiquitination and degradation of phosphorylated ARM"/>
            <pathway-xref db="Reactome" id="R-RNO-525793" name="Myogenesis"/>
            <pathway-xref db="Reactome" id="R-DDI-5628897" name="TP53 Regulates Metabolic Genes"/>
            <pathway-xref db="Reactome" id="R-SPO-75955" name="RNA Polymerase II Transcription Elongation"/>
            <pathway-xref db="Reactome" id="R-DDI-2514853" name="Condensation of Prometaphase Chromosomes"/>
            <pathway-xref db="Reactome" id="R-RNO-380270" name="Recruitment of mitotic centrosome proteins and complexes"/>
            <pathway-xref db="Reactome" id="R-HSA-9649948" name="Signaling downstream of RAS mutants"/>
            <pathway-xref db="Reactome" id="R-MMU-8874081" name="MET activates PTK2 signaling"/>
            <pathway-xref db="Reactome" id="R-CEL-442742" name="CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling"/>
            <pathway-xref db="Reactome" id="R-DME-5687128" name="MAPK6/MAPK4 signaling"/>
            <pathway-xref db="Reactome" id="R-GGA-399954" name="Sema3A PAK dependent Axon repulsion"/>
            <pathway-xref db="Reactome" id="R-DME-390023" name="Subcellular localisation of D"/>
            <pathway-xref db="Reactome" id="R-MMU-389948" name="PD-1 signaling"/>
            <pathway-xref db="Reactome" id="R-DME-1295596" name="Spry regulation of FGF signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-5693565" name="Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"/>
            <pathway-xref db="Reactome" id="R-CEL-77075" name="RNA Pol II CTD phosphorylation and interaction with CE"/>
            <pathway-xref db="Reactome" id="R-DRE-9018519" name="Estrogen-dependent gene expression"/>
            <pathway-xref db="Reactome" id="R-HSA-1502540" name="Signaling by Activin"/>
            <pathway-xref db="Reactome" id="R-DRE-3371571" name="HSF1-dependent transactivation"/>
            <pathway-xref db="Reactome" id="R-RNO-399997" name="Acetylcholine regulates insulin secretion"/>
            <pathway-xref db="Reactome" id="R-HSA-5358749" name="S37 mutants of beta-catenin aren't phosphorylated"/>
            <pathway-xref db="Reactome" id="R-DME-399955" name="SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion"/>
            <pathway-xref db="Reactome" id="R-HSA-73728" name="RNA Polymerase I Promoter Opening"/>
            <pathway-xref db="Reactome" id="R-HSA-933541" name="TRAF6 mediated IRF7 activation"/>
            <pathway-xref db="Reactome" id="R-XTR-1169091" name="Activation of NF-kappaB in B cells"/>
            <pathway-xref db="Reactome" id="R-CEL-182971" name="EGFR downregulation"/>
            <pathway-xref db="Reactome" id="R-RNO-209543" name="p75NTR recruits signalling complexes"/>
            <pathway-xref db="Reactome" id="R-HSA-8853336" name="Signaling by plasma membrane FGFR1 fusions"/>
            <pathway-xref db="Reactome" id="R-HSA-1839122" name="Signaling by activated point mutants of FGFR1"/>
            <pathway-xref db="Reactome" id="R-MMU-8934593" name="Regulation of RUNX1 Expression and Activity"/>
            <pathway-xref db="Reactome" id="R-SSC-8854050" name="FBXL7 down-regulates AURKA during mitotic entry and in early mitosis"/>
            <pathway-xref db="Reactome" id="R-DME-450604" name="KSRP (KHSRP) binds and destabilizes mRNA"/>
            <pathway-xref db="Reactome" id="R-RNO-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-9617324" name="Negative regulation of NMDA receptor-mediated neuronal transmission"/>
            <pathway-xref db="Reactome" id="R-BTA-6804756" name="Regulation of TP53 Activity through Phosphorylation"/>
            <pathway-xref db="Reactome" id="R-XTR-4419969" name="Depolymerisation of the Nuclear Lamina"/>
            <pathway-xref db="Reactome" id="R-MMU-165181" name="Inhibition of TSC complex formation by PKB"/>
            <pathway-xref db="Reactome" id="R-RNO-9616222" name="Transcriptional regulation of granulopoiesis"/>
            <pathway-xref db="Reactome" id="R-HSA-2454202" name="Fc epsilon receptor (FCERI) signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-5693616" name="Presynaptic phase of homologous DNA pairing and strand exchange"/>
            <pathway-xref db="Reactome" id="R-CFA-1433557" name="Signaling by SCF-KIT"/>
            <pathway-xref db="Reactome" id="R-HSA-389356" name="CD28 co-stimulation"/>
            <pathway-xref db="Reactome" id="R-SPO-9013148" name="CDC42 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DDI-2029482" name="Regulation of actin dynamics for phagocytic cup formation"/>
            <pathway-xref db="Reactome" id="R-RNO-5690714" name="CD22 mediated BCR regulation"/>
            <pathway-xref db="Reactome" id="R-DME-209440" name="Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM"/>
            <pathway-xref db="Reactome" id="R-HSA-163680" name="AMPK inhibits chREBP transcriptional activation activity"/>
            <pathway-xref db="Reactome" id="R-HSA-3304356" name="SMAD2/3 Phosphorylation Motif Mutants in Cancer"/>
            <pathway-xref db="Reactome" id="R-SCE-73776" name="RNA Polymerase II Promoter Escape"/>
            <pathway-xref db="Reactome" id="R-RNO-1963640" name="GRB2 events in ERBB2 signaling"/>
            <pathway-xref db="Reactome" id="R-CEL-198753" name="ERK/MAPK targets"/>
            <pathway-xref db="Reactome" id="R-DDI-164378" name="PKA activation in glucagon signalling"/>
            <pathway-xref db="Reactome" id="R-HSA-9686347" name="Microbial modulation of RIPK1-mediated regulated necrosis"/>
            <pathway-xref db="Reactome" id="R-RNO-9648025" name="EML4 and NUDC in mitotic spindle formation"/>
            <pathway-xref db="Reactome" id="R-HSA-190377" name="FGFR2b ligand binding and activation"/>
            <pathway-xref db="Reactome" id="R-HSA-2173791" name="TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)"/>
            <pathway-xref db="Reactome" id="R-DRE-5654704" name="SHC-mediated cascade:FGFR3"/>
            <pathway-xref db="Reactome" id="R-RNO-2173789" name="TGF-beta receptor signaling activates SMADs"/>
            <pathway-xref db="Reactome" id="R-DRE-912526" name="Interleukin receptor SHC signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-5654720" name="PI-3K cascade:FGFR4"/>
            <pathway-xref db="Reactome" id="R-MMU-5578775" name="Ion homeostasis"/>
            <pathway-xref db="Reactome" id="R-DRE-5654732" name="Negative regulation of FGFR3 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-5654720" name="PI-3K cascade:FGFR4"/>
            <pathway-xref db="Reactome" id="R-DME-2995383" name="Initiation of Nuclear Envelope (NE) Reformation"/>
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            <pathway-xref db="Reactome" id="R-BTA-196299" name="Beta-catenin phosphorylation cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-112409" name="RAF-independent MAPK1/3 activation"/>
            <pathway-xref db="Reactome" id="R-HSA-5578775" name="Ion homeostasis"/>
            <pathway-xref db="Reactome" id="R-DME-1433559" name="Regulation of KIT signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-196299" name="Beta-catenin phosphorylation cascade"/>
            <pathway-xref db="Reactome" id="R-SCE-111932" name="CaMK IV-mediated phosphorylation of CREB"/>
            <pathway-xref db="Reactome" id="R-SPO-389357" name="CD28 dependent PI3K/Akt signaling"/>
            <pathway-xref db="Reactome" id="R-CEL-381676" name="Glucagon-like Peptide-1 (GLP1) regulates insulin secretion"/>
            <pathway-xref db="Reactome" id="R-RNO-2173788" name="Downregulation of TGF-beta receptor signaling"/>
            <pathway-xref db="Reactome" id="R-CEL-69202" name="Cyclin E associated events during G1/S transition"/>
            <pathway-xref db="Reactome" id="R-DRE-69202" name="Cyclin E associated events during G1/S transition"/>
            <pathway-xref db="Reactome" id="R-HSA-9034864" name="Activated NTRK3 signals through RAS"/>
            <pathway-xref db="Reactome" id="R-CEL-111933" name="Calmodulin induced events"/>
            <pathway-xref db="Reactome" id="R-MMU-8854050" name="FBXL7 down-regulates AURKA during mitotic entry and in early mitosis"/>
            <pathway-xref db="Reactome" id="R-CEL-68949" name="Orc1 removal from chromatin"/>
            <pathway-xref db="Reactome" id="R-SPO-450321" name="JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1"/>
            <pathway-xref db="Reactome" id="R-HSA-2465910" name="MASTL Facilitates Mitotic Progression"/>
            <pathway-xref db="Reactome" id="R-DME-392517" name="Rap1 signalling"/>
            <pathway-xref db="Reactome" id="R-HSA-190375" name="FGFR2c ligand binding and activation"/>
            <pathway-xref db="Reactome" id="R-RNO-170984" name="ARMS-mediated activation"/>
            <pathway-xref db="Reactome" id="R-GGA-2173788" name="Downregulation of TGF-beta receptor signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-5675482" name="Regulation of necroptotic cell death"/>
            <pathway-xref db="Reactome" id="R-DME-1227986" name="Signaling by ERBB2"/>
            <pathway-xref db="Reactome" id="R-SPO-2730905" name="Role of LAT2/NTAL/LAB on calcium mobilization"/>
            <pathway-xref db="Reactome" id="R-HSA-9702581" name="crenolanib-resistant FLT3 mutants"/>
            <pathway-xref db="Reactome" id="R-CEL-198323" name="AKT phosphorylates targets in the cytosol"/>
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            <pathway-xref db="Reactome" id="R-CEL-3371571" name="HSF1-dependent transactivation"/>
            <pathway-xref db="Reactome" id="R-MMU-68877" name="Mitotic Prometaphase"/>
            <pathway-xref db="Reactome" id="R-SSC-8849470" name="PTK6 Regulates Cell Cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-5696395" name="Formation of Incision Complex in GG-NER"/>
            <pathway-xref db="Reactome" id="R-RNO-199920" name="CREB phosphorylation"/>
            <pathway-xref db="Reactome" id="R-DDI-380972" name="Energy dependent regulation of mTOR by LKB1-AMPK"/>
            <pathway-xref db="Reactome" id="R-HSA-195253" name="Degradation of beta-catenin by the destruction complex"/>
            <pathway-xref db="Reactome" id="R-CFA-525793" name="Myogenesis"/>
            <pathway-xref db="Reactome" id="R-HSA-5654219" name="Phospholipase C-mediated cascade: FGFR1"/>
            <pathway-xref db="Reactome" id="R-CEL-437239" name="Recycling pathway of L1"/>
            <pathway-xref db="Reactome" id="R-HSA-9026357" name="NTF4 activates NTRK2 (TRKB) signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9702632" name="sunitinib-resistant FLT3 mutants"/>
            <pathway-xref db="Reactome" id="R-HSA-2299718" name="Condensation of Prophase Chromosomes"/>
            <pathway-xref db="Reactome" id="R-DRE-168638" name="NOD1/2 Signaling Pathway"/>
            <pathway-xref db="Reactome" id="R-HSA-174048" name="APC/C:Cdc20 mediated degradation of Cyclin B"/>
            <pathway-xref db="Reactome" id="R-HSA-8943724" name="Regulation of PTEN gene transcription"/>
            <pathway-xref db="Reactome" id="R-HSA-202433" name="Generation of second messenger molecules"/>
            <pathway-xref db="Reactome" id="R-HSA-3295583" name="TRP channels"/>
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            <pathway-xref db="Reactome" id="R-HSA-9703465" name="Signaling by FLT3 fusion proteins"/>
            <pathway-xref db="Reactome" id="R-CEL-354192" name="Integrin signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-2299718" name="Condensation of Prophase Chromosomes"/>
            <pathway-xref db="Reactome" id="R-GGA-3928663" name="EPHA-mediated growth cone collapse"/>
            <pathway-xref db="Reactome" id="R-MMU-3295583" name="TRP channels"/>
            <pathway-xref db="Reactome" id="R-SCE-69656" name="Cyclin A:Cdk2-associated events at S phase entry"/>
            <pathway-xref db="Reactome" id="R-CEL-9614399" name="Regulation of localization of FOXO transcription factors"/>
            <pathway-xref db="Reactome" id="R-MMU-2173796" name="SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription"/>
            <pathway-xref db="Reactome" id="R-RNO-6814122" name="Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"/>
            <pathway-xref db="Reactome" id="R-RNO-881907" name="Gastrin-CREB signalling pathway via PKC and MAPK"/>
            <pathway-xref db="Reactome" id="R-DRE-6804757" name="Regulation of TP53 Degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-176408" name="Regulation of APC/C activators between G1/S and early anaphase"/>
            <pathway-xref db="Reactome" id="R-DME-6811558" name="PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"/>
            <pathway-xref db="Reactome" id="R-DME-114508" name="Effects of PIP2 hydrolysis"/>
            <pathway-xref db="Reactome" id="R-GGA-8941858" name="Regulation of RUNX3 expression and activity"/>
            <pathway-xref db="Reactome" id="R-MMU-203615" name="eNOS activation"/>
            <pathway-xref db="Reactome" id="R-HSA-180024" name="DARPP-32 events"/>
            <pathway-xref db="Reactome" id="R-MMU-8854691" name="Interleukin-20 family signaling"/>
            <pathway-xref db="Reactome" id="R-BTA-75815" name="Ubiquitin-dependent degradation of Cyclin D"/>
            <pathway-xref db="Reactome" id="R-HSA-1362300" name="Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1"/>
            <pathway-xref db="Reactome" id="R-HSA-9669914" name="Dasatinib-resistant KIT mutants"/>
            <pathway-xref db="Reactome" id="R-HSA-202430" name="Translocation of ZAP-70 to Immunological synapse"/>
            <pathway-xref db="Reactome" id="R-DME-4419969" name="Depolymerisation of the Nuclear Lamina"/>
            <pathway-xref db="Reactome" id="R-RNO-186797" name="Signaling by PDGF"/>
            <pathway-xref db="Reactome" id="R-CEL-5674499" name="Negative feedback regulation of MAPK pathway"/>
            <pathway-xref db="Reactome" id="R-MMU-5673001" name="RAF/MAP kinase cascade"/>
            <pathway-xref db="Reactome" id="R-DME-5654733" name="Negative regulation of FGFR4 signaling"/>
            <pathway-xref db="Reactome" id="R-DME-416476" name="G alpha (q) signalling events"/>
            <pathway-xref db="Reactome" id="R-DDI-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-CEL-199418" name="Negative regulation of the PI3K/AKT network"/>
            <pathway-xref db="Reactome" id="R-DDI-69202" name="Cyclin E associated events during G1/S transition"/>
            <pathway-xref db="Reactome" id="R-GGA-354192" name="Integrin signaling"/>
            <pathway-xref db="Reactome" id="R-CEL-5673000" name="RAF activation"/>
            <pathway-xref db="Reactome" id="R-MMU-69656" name="Cyclin A:Cdk2-associated events at S phase entry"/>
            <pathway-xref db="Reactome" id="R-DME-9634635" name="Estrogen-stimulated signaling through PRKCZ"/>
            <pathway-xref db="Reactome" id="R-SPO-114508" name="Effects of PIP2 hydrolysis"/>
            <pathway-xref db="Reactome" id="R-DME-2559582" name="Senescence-Associated Secretory Phenotype (SASP)"/>
            <pathway-xref db="Reactome" id="R-HSA-167243" name="Tat-mediated HIV elongation arrest and recovery"/>
            <pathway-xref db="Reactome" id="R-DRE-975144" name="IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation"/>
            <pathway-xref db="Reactome" id="R-MMU-5654219" name="Phospholipase C-mediated cascade: FGFR1"/>
            <pathway-xref db="Reactome" id="R-RNO-6804758" name="Regulation of TP53 Activity through Acetylation"/>
            <pathway-xref db="Reactome" id="R-DME-512988" name="Interleukin-3, Interleukin-5 and GM-CSF signaling"/>
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            <pathway-xref db="Reactome" id="R-HSA-8854691" name="Interleukin-20 family signaling"/>
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            <pathway-xref db="Reactome" id="R-MMU-111932" name="CaMK IV-mediated phosphorylation of CREB"/>
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            <pathway-xref db="Reactome" id="R-SPO-3371453" name="Regulation of HSF1-mediated heat shock response"/>
            <pathway-xref db="Reactome" id="R-DME-6804759" name="Regulation of TP53 Activity through Association with Co-factors"/>
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            <pathway-xref db="Reactome" id="R-DME-438066" name="Unblocking of NMDA receptors, glutamate binding and activation"/>
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            <pathway-xref db="Reactome" id="R-HSA-163560" name="Triglyceride catabolism"/>
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            <pathway-xref db="Reactome" id="R-DDI-8854214" name="TBC/RABGAPs"/>
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            <pathway-xref db="Reactome" id="R-SPO-5668599" name="RHO GTPases Activate NADPH Oxidases"/>
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            <pathway-xref db="Reactome" id="R-DRE-8980692" name="RHOA GTPase cycle"/>
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            <pathway-xref db="Reactome" id="R-RNO-430116" name="GP1b-IX-V activation signalling"/>
            <pathway-xref db="Reactome" id="R-HSA-936440" name="Negative regulators of DDX58/IFIH1 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-9020933" name="Interleukin-23 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-8852276" name="The role of GTSE1 in G2/M progression after G2 checkpoint"/>
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            <pathway-xref db="Reactome" id="R-DDI-4086398" name="Ca2+ pathway"/>
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            <pathway-xref db="Reactome" id="R-HSA-9026527" name="Activated NTRK2 signals through PLCG1"/>
            <pathway-xref db="Reactome" id="R-MMU-170968" name="Frs2-mediated activation"/>
            <pathway-xref db="Reactome" id="R-RNO-6791226" name="Major pathway of rRNA processing in the nucleolus and cytosol"/>
            <pathway-xref db="Reactome" id="R-SCE-72086" name="mRNA Capping"/>
            <pathway-xref db="Reactome" id="R-MMU-983695" name="Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"/>
            <pathway-xref db="Reactome" id="R-SPO-112411" name="MAPK1 (ERK2) activation"/>
            <pathway-xref db="Reactome" id="R-SCE-4086398" name="Ca2+ pathway"/>
            <pathway-xref db="Reactome" id="R-RNO-68911" name="G2 Phase"/>
            <pathway-xref db="Reactome" id="R-HSA-69231" name="Cyclin D associated events in G1"/>
            <pathway-xref db="Reactome" id="R-HSA-212718" name="EGFR interacts with phospholipase C-gamma"/>
            <pathway-xref db="Reactome" id="R-DME-5654726" name="Negative regulation of FGFR1 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-9607240" name="FLT3 Signaling"/>
            <pathway-xref db="Reactome" id="R-DME-190371" name="FGFR3b ligand binding and activation"/>
            <pathway-xref db="Reactome" id="R-SSC-2424491" name="DAP12 signaling"/>
            <pathway-xref db="Reactome" id="R-SPO-69601" name="Ubiquitin Mediated Degradation of Phosphorylated Cdc25A"/>
            <pathway-xref db="Reactome" id="R-RNO-2454202" name="Fc epsilon receptor (FCERI) signaling"/>
            <pathway-xref db="Reactome" id="R-CEL-442720" name="CREB1 phosphorylation through the activation of Adenylate Cyclase"/>
            <pathway-xref db="Reactome" id="R-HSA-3249367" name="STAT6-mediated induction of chemokines"/>
            <pathway-xref db="Reactome" id="R-CEL-9634638" name="Estrogen-dependent nuclear events downstream of ESR-membrane signaling"/>
            <pathway-xref db="Reactome" id="R-SCE-111995" name="phospho-PLA2 pathway"/>
            <pathway-xref db="Reactome" id="R-DRE-5576892" name="Phase 0 - rapid depolarisation"/>
            <pathway-xref db="Reactome" id="R-CEL-3928662" name="EPHB-mediated forward signaling"/>
            <pathway-xref db="Reactome" id="R-CEL-5218920" name="VEGFR2 mediated vascular permeability"/>
            <pathway-xref db="Reactome" id="R-MMU-8878166" name="Transcriptional regulation by RUNX2"/>
            <pathway-xref db="Reactome" id="R-HSA-69563" name="p53-Dependent G1 DNA Damage Response"/>
            <pathway-xref db="Reactome" id="R-DME-5625886" name="Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3"/>
            <pathway-xref db="Reactome" id="R-HSA-202424" name="Downstream TCR signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9034015" name="Signaling by NTRK3 (TRKC)"/>
            <pathway-xref db="Reactome" id="R-CFA-4086398" name="Ca2+ pathway"/>
            <pathway-xref db="Reactome" id="R-RNO-5696395" name="Formation of Incision Complex in GG-NER"/>
            <pathway-xref db="Reactome" id="R-MMU-199920" name="CREB phosphorylation"/>
            <pathway-xref db="Reactome" id="R-DME-418592" name="ADP signalling through P2Y purinoceptor 1"/>
            <pathway-xref db="Reactome" id="R-MMU-8851805" name="MET activates RAS signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-5685938" name="HDR through Single Strand Annealing (SSA)"/>
            <pathway-xref db="Reactome" id="R-HSA-8939246" name="RUNX1 regulates transcription of genes involved in differentiation of myeloid cells"/>
            <pathway-xref db="Reactome" id="R-SCE-381042" name="PERK regulates gene expression"/>
            <pathway-xref db="Reactome" id="R-MMU-2562578" name="TRIF-mediated programmed cell death"/>
            <pathway-xref db="Reactome" id="R-XTR-76005" name="Response to elevated platelet cytosolic Ca2+"/>
            <pathway-xref db="Reactome" id="R-SPO-389513" name="CTLA4 inhibitory signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-373752" name="Netrin-1 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-8851805" name="MET activates RAS signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-168638" name="NOD1/2 Signaling Pathway"/>
            <pathway-xref db="Reactome" id="R-HSA-2562578" name="TRIF-mediated programmed cell death"/>
            <pathway-xref db="Reactome" id="R-DDI-5621575" name="CD209 (DC-SIGN) signaling"/>
            <pathway-xref db="Reactome" id="R-SCE-1489509" name="DAG and IP3 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-354192" name="Integrin signaling"/>
            <pathway-xref db="Reactome" id="R-SSC-2559580" name="Oxidative Stress Induced Senescence"/>
            <pathway-xref db="Reactome" id="R-RNO-420029" name="Tight junction interactions"/>
            <pathway-xref db="Reactome" id="R-RNO-5620912" name="Anchoring of the basal body to the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-DME-2871796" name="FCERI mediated MAPK activation"/>
            <pathway-xref db="Reactome" id="R-BTA-9013406" name="RHOQ GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-9634638" name="Estrogen-dependent nuclear events downstream of ESR-membrane signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-5654688" name="SHC-mediated cascade:FGFR1"/>
            <pathway-xref db="Reactome" id="R-CEL-399997" name="Acetylcholine regulates insulin secretion"/>
            <pathway-xref db="Reactome" id="R-CEL-1169408" name="ISG15 antiviral mechanism"/>
            <pathway-xref db="Reactome" id="R-HSA-3371453" name="Regulation of HSF1-mediated heat shock response"/>
            <pathway-xref db="Reactome" id="R-MMU-180292" name="GAB1 signalosome"/>
            <pathway-xref db="Reactome" id="R-MMU-1251985" name="Nuclear signaling by ERBB4"/>
            <pathway-xref db="Reactome" id="R-SCE-6804115" name="TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"/>
            <pathway-xref db="Reactome" id="R-DRE-9031628" name="NGF-stimulated transcription"/>
            <pathway-xref db="Reactome" id="R-RNO-8854050" name="FBXL7 down-regulates AURKA during mitotic entry and in early mitosis"/>
            <pathway-xref db="Reactome" id="R-CEL-8876198" name="RAB GEFs exchange GTP for GDP on RABs"/>
            <pathway-xref db="Reactome" id="R-MMU-6783783" name="Interleukin-10 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-389359" name="CD28 dependent Vav1 pathway"/>
            <pathway-xref db="Reactome" id="R-GGA-1433557" name="Signaling by SCF-KIT"/>
            <pathway-xref db="Reactome" id="R-SCE-76005" name="Response to elevated platelet cytosolic Ca2+"/>
            <pathway-xref db="Reactome" id="R-DME-8948751" name="Regulation of PTEN stability and activity"/>
            <pathway-xref db="Reactome" id="R-HSA-174178" name="APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1"/>
            <pathway-xref db="Reactome" id="R-RNO-193648" name="NRAGE signals death through JNK"/>
            <pathway-xref db="Reactome" id="R-MMU-5654228" name="Phospholipase C-mediated cascade, FGFR4"/>
            <pathway-xref db="Reactome" id="R-HSA-190322" name="FGFR4 ligand binding and activation"/>
            <pathway-xref db="Reactome" id="R-HSA-456926" name="Thrombin signalling through proteinase activated receptors (PARs)"/>
            <pathway-xref db="Reactome" id="R-DME-442729" name="CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde"/>
            <pathway-xref db="Reactome" id="R-DRE-6791226" name="Major pathway of rRNA processing in the nucleolus and cytosol"/>
            <pathway-xref db="Reactome" id="R-RNO-5357956" name="TNFR1-induced NFkappaB signaling pathway"/>
            <pathway-xref db="Reactome" id="R-SCE-442729" name="CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde"/>
            <pathway-xref db="Reactome" id="R-DRE-389356" name="CD28 co-stimulation"/>
            <pathway-xref db="Reactome" id="R-SCE-432142" name="Platelet sensitization by LDL"/>
            <pathway-xref db="Reactome" id="R-RNO-2514853" name="Condensation of Prometaphase Chromosomes"/>
            <pathway-xref db="Reactome" id="R-SPO-73776" name="RNA Polymerase II Promoter Escape"/>
            <pathway-xref db="Reactome" id="R-MMU-114516" name="Disinhibition of SNARE formation"/>
            <pathway-xref db="Reactome" id="R-DRE-1266695" name="Interleukin-7 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-5663213" name="RHO GTPases Activate WASPs and WAVEs"/>
            <pathway-xref db="Reactome" id="R-GGA-388844" name="Receptor-type tyrosine-protein phosphatases"/>
            <pathway-xref db="Reactome" id="R-HSA-8854518" name="AURKA Activation by TPX2"/>
            <pathway-xref db="Reactome" id="R-HSA-5654228" name="Phospholipase C-mediated cascade, FGFR4"/>
            <pathway-xref db="Reactome" id="R-DME-209338" name="Assembly of the 'signalling complexes'"/>
            <pathway-xref db="Reactome" id="R-HSA-937039" name="IRAK1 recruits IKK complex"/>
            <pathway-xref db="Reactome" id="R-MMU-6796648" name="TP53 Regulates Transcription of DNA Repair Genes"/>
            <pathway-xref db="Reactome" id="R-HSA-167172" name="Transcription of the HIV genome"/>
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            <pathway-xref db="Reactome" id="R-SCE-6781823" name="Formation of TC-NER Pre-Incision Complex"/>
            <pathway-xref db="Reactome" id="R-SPO-75953" name="RNA Polymerase II Transcription Initiation"/>
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            <pathway-xref db="Reactome" id="R-MMU-5675482" name="Regulation of necroptotic cell death"/>
            <pathway-xref db="Reactome" id="R-DRE-141444" name="Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"/>
            <pathway-xref db="Reactome" id="R-RNO-198323" name="AKT phosphorylates targets in the cytosol"/>
            <pathway-xref db="Reactome" id="R-MMU-449836" name="Other interleukin signaling"/>
            <pathway-xref db="Reactome" id="R-GGA-1227892" name="TRAF6 mediated NF-kB activation"/>
            <pathway-xref db="Reactome" id="R-BTA-1433557" name="Signaling by SCF-KIT"/>
            <pathway-xref db="Reactome" id="R-CEL-6804114" name="TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest"/>
            <pathway-xref db="Reactome" id="R-MMU-114604" name="GPVI-mediated activation cascade"/>
            <pathway-xref db="Reactome" id="R-MMU-174184" name="Cdc20:Phospho-APC/C mediated degradation of Cyclin A"/>
            <pathway-xref db="Reactome" id="R-DME-1963642" name="PI3K events in ERBB2 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-8853338" name="Signaling by FGFR3 point mutants in cancer"/>
            <pathway-xref db="Reactome" id="R-BTA-9013420" name="RHOU GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-GGA-199920" name="CREB phosphorylation"/>
            <pathway-xref db="Reactome" id="R-MMU-68884" name="Mitotic Telophase/Cytokinesis"/>
            <pathway-xref db="Reactome" id="R-DME-8856828" name="Clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-RNO-9013424" name="RHOV GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-SPO-156711" name="Polo-like kinase mediated events"/>
            <pathway-xref db="Reactome" id="R-RNO-2029482" name="Regulation of actin dynamics for phagocytic cup formation"/>
            <pathway-xref db="Reactome" id="R-CEL-9607240" name="FLT3 Signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-167590" name="Nef Mediated CD4 Down-regulation"/>
            <pathway-xref db="Reactome" id="R-MMU-9634638" name="Estrogen-dependent nuclear events downstream of ESR-membrane signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-416993" name="Trafficking of GluR2-containing AMPA receptors"/>
            <pathway-xref db="Reactome" id="R-MMU-1474151" name="Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation"/>
            <pathway-xref db="Reactome" id="R-HSA-156711" name="Polo-like kinase mediated events"/>
            <pathway-xref db="Reactome" id="R-CEL-5693565" name="Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"/>
            <pathway-xref db="Reactome" id="R-HSA-1474151" name="Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation"/>
            <pathway-xref db="Reactome" id="R-MMU-76005" name="Response to elevated platelet cytosolic Ca2+"/>
            <pathway-xref db="Reactome" id="R-XTR-5218921" name="VEGFR2 mediated cell proliferation"/>
            <pathway-xref db="Reactome" id="R-DRE-112411" name="MAPK1 (ERK2) activation"/>
            <pathway-xref db="Reactome" id="R-BTA-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-SPO-5693616" name="Presynaptic phase of homologous DNA pairing and strand exchange"/>
            <pathway-xref db="Reactome" id="R-RNO-9034013" name="NTF3 activates NTRK3 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-8875791" name="MET activates STAT3"/>
            <pathway-xref db="Reactome" id="R-CEL-2559586" name="DNA Damage/Telomere Stress Induced Senescence"/>
            <pathway-xref db="Reactome" id="R-DME-176187" name="Activation of ATR in response to replication stress"/>
            <pathway-xref db="Reactome" id="R-SCE-5687128" name="MAPK6/MAPK4 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-2179392" name="EGFR Transactivation by Gastrin"/>
            <pathway-xref db="Reactome" id="R-RNO-68962" name="Activation of the pre-replicative complex"/>
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            <pathway-xref db="Reactome" id="R-MMU-8875791" name="MET activates STAT3"/>
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            <pathway-xref db="Reactome" id="R-DME-5654712" name="FRS-mediated FGFR4 signaling"/>
            <pathway-xref db="Reactome" id="R-DME-5654221" name="Phospholipase C-mediated cascade, FGFR2"/>
            <pathway-xref db="Reactome" id="R-HSA-936837" name="Ion transport by P-type ATPases"/>
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            <pathway-xref db="Reactome" id="R-MMU-5654221" name="Phospholipase C-mediated cascade, FGFR2"/>
            <pathway-xref db="Reactome" id="R-MMU-9013106" name="RHOC GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DME-5654727" name="Negative regulation of FGFR2 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-216083" name="Integrin cell surface interactions"/>
            <pathway-xref db="Reactome" id="R-MMU-5654704" name="SHC-mediated cascade:FGFR3"/>
            <pathway-xref db="Reactome" id="R-BTA-8849470" name="PTK6 Regulates Cell Cycle"/>
            <pathway-xref db="Reactome" id="R-SCE-162658" name="Golgi Cisternae Pericentriolar Stack Reorganization"/>
            <pathway-xref db="Reactome" id="R-CEL-198693" name="AKT phosphorylates targets in the nucleus"/>
            <pathway-xref db="Reactome" id="R-DDI-3371453" name="Regulation of HSF1-mediated heat shock response"/>
            <pathway-xref db="Reactome" id="R-HSA-6804116" name="TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest"/>
            <pathway-xref db="Reactome" id="R-DRE-5654688" name="SHC-mediated cascade:FGFR1"/>
            <pathway-xref db="Reactome" id="R-SCE-399997" name="Acetylcholine regulates insulin secretion"/>
            <pathway-xref db="Reactome" id="R-CEL-8874081" name="MET activates PTK2 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-162658" name="Golgi Cisternae Pericentriolar Stack Reorganization"/>
            <pathway-xref db="Reactome" id="R-RNO-5635838" name="Activation of SMO"/>
            <pathway-xref db="Reactome" id="R-HSA-3656535" name="TGFBR1 LBD Mutants in Cancer"/>
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            <pathway-xref db="Reactome" id="R-HSA-8856828" name="Clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-RNO-9031628" name="NGF-stimulated transcription"/>
            <pathway-xref db="Reactome" id="R-PFA-5610787" name="Hedgehog 'off' state"/>
            <pathway-xref db="Reactome" id="R-HSA-5668599" name="RHO GTPases Activate NADPH Oxidases"/>
            <pathway-xref db="Reactome" id="R-HSA-109704" name="PI3K Cascade"/>
            <pathway-xref db="Reactome" id="R-CEL-177929" name="Signaling by EGFR"/>
            <pathway-xref db="Reactome" id="R-MMU-70221" name="Glycogen breakdown (glycogenolysis)"/>
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            <pathway-xref db="Reactome" id="R-RNO-5099900" name="WNT5A-dependent internalization of FZD4"/>
            <pathway-xref db="Reactome" id="R-CEL-5628897" name="TP53 Regulates Metabolic Genes"/>
            <pathway-xref db="Reactome" id="R-DME-114516" name="Disinhibition of SNARE formation"/>
            <pathway-xref db="Reactome" id="R-MMU-72086" name="mRNA Capping"/>
            <pathway-xref db="Reactome" id="R-CEL-68884" name="Mitotic Telophase/Cytokinesis"/>
            <pathway-xref db="Reactome" id="R-HSA-3134975" name="Regulation of innate immune responses to cytosolic DNA"/>
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            <pathway-xref db="Reactome" id="R-CEL-430116" name="GP1b-IX-V activation signalling"/>
            <pathway-xref db="Reactome" id="R-RNO-1266695" name="Interleukin-7 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-416572" name="Sema4D induced cell migration and growth-cone collapse"/>
            <pathway-xref db="Reactome" id="R-GGA-8874081" name="MET activates PTK2 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-450302" name="activated TAK1 mediates p38 MAPK activation"/>
            <pathway-xref db="Reactome" id="R-MMU-163615" name="PKA activation"/>
            <pathway-xref db="Reactome" id="R-MMU-204005" name="COPII-mediated vesicle transport"/>
            <pathway-xref db="Reactome" id="R-DME-9013407" name="RHOH GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DME-392451" name="G beta:gamma signalling through PI3Kgamma"/>
            <pathway-xref db="Reactome" id="R-SPO-5693565" name="Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"/>
            <pathway-xref db="Reactome" id="R-DRE-210990" name="PECAM1 interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-8984722" name="Interleukin-35 Signalling"/>
            <pathway-xref db="Reactome" id="R-HSA-933543" name="NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10"/>
            <pathway-xref db="Reactome" id="R-MMU-210993" name="Tie2 Signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-68911" name="G2 Phase"/>
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            <pathway-xref db="Reactome" id="R-MMU-8984722" name="Interleukin-35 Signalling"/>
            <pathway-xref db="Reactome" id="R-HSA-975871" name="MyD88 cascade initiated on plasma membrane"/>
            <pathway-xref db="Reactome" id="R-MMU-3134975" name="Regulation of innate immune responses to cytosolic DNA"/>
            <pathway-xref db="Reactome" id="R-CEL-5673001" name="RAF/MAP kinase cascade"/>
            <pathway-xref db="Reactome" id="R-RNO-1912408" name="Pre-NOTCH Transcription and Translation"/>
            <pathway-xref db="Reactome" id="R-DME-442720" name="CREB1 phosphorylation through the activation of Adenylate Cyclase"/>
            <pathway-xref db="Reactome" id="R-DRE-380270" name="Recruitment of mitotic centrosome proteins and complexes"/>
            <pathway-xref db="Reactome" id="R-MMU-2980767" name="Activation of NIMA Kinases NEK9, NEK6, NEK7"/>
            <pathway-xref db="Reactome" id="R-RNO-5625740" name="RHO GTPases activate PKNs"/>
            <pathway-xref db="Reactome" id="R-HSA-73779" name="RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"/>
            <pathway-xref db="Reactome" id="R-RNO-69473" name="G2/M DNA damage checkpoint"/>
            <pathway-xref db="Reactome" id="R-HSA-975163" name="IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation"/>
            <pathway-xref db="Reactome" id="R-HSA-212436" name="Generic Transcription Pathway"/>
            <pathway-xref db="Reactome" id="R-RNO-450321" name="JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1"/>
            <pathway-xref db="Reactome" id="R-RNO-9696264" name="RND3 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-3656532" name="TGFBR1 KD Mutants in Cancer"/>
            <pathway-xref db="Reactome" id="R-RNO-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-DME-8985947" name="Interleukin-9 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-8856828" name="Clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-RNO-432142" name="Platelet sensitization by LDL"/>
            <pathway-xref db="Reactome" id="R-CEL-418592" name="ADP signalling through P2Y purinoceptor 1"/>
            <pathway-xref db="Reactome" id="R-RNO-399954" name="Sema3A PAK dependent Axon repulsion"/>
            <pathway-xref db="Reactome" id="R-MMU-211163" name="AKT-mediated inactivation of FOXO1A"/>
            <pathway-xref db="Reactome" id="R-DRE-5357905" name="Regulation of TNFR1 signaling"/>
            <pathway-xref db="Reactome" id="R-DDI-392517" name="Rap1 signalling"/>
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            <pathway-xref db="Reactome" id="R-HSA-9703648" name="Signaling by FLT3 ITD and TKD mutants"/>
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            <pathway-xref db="Reactome" id="R-CEL-450341" name="Activation of the AP-1 family of transcription factors"/>
            <pathway-xref db="Reactome" id="R-HSA-176412" name="Phosphorylation of the APC/C"/>
            <pathway-xref db="Reactome" id="R-DDI-9619229" name="Activation of RAC1 downstream of NMDARs"/>
            <pathway-xref db="Reactome" id="R-CEL-200425" name="Carnitine metabolism"/>
            <pathway-xref db="Reactome" id="R-RNO-165181" name="Inhibition of TSC complex formation by PKB"/>
            <pathway-xref db="Reactome" id="R-SSC-389356" name="CD28 co-stimulation"/>
            <pathway-xref db="Reactome" id="R-SSC-399956" name="CRMPs in Sema3A signaling"/>
            <pathway-xref db="Reactome" id="R-BTA-389357" name="CD28 dependent PI3K/Akt signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9665686" name="Signaling by ERBB2 TMD/JMD mutants"/>
            <pathway-xref db="Reactome" id="R-DDI-114604" name="GPVI-mediated activation cascade"/>
            <pathway-xref db="Reactome" id="R-MMU-5625886" name="Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3"/>
            <pathway-xref db="Reactome" id="R-MMU-909733" name="Interferon alpha/beta signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-2500257" name="Resolution of Sister Chromatid Cohesion"/>
            <pathway-xref db="Reactome" id="R-GGA-389356" name="CD28 co-stimulation"/>
            <pathway-xref db="Reactome" id="R-RNO-9634635" name="Estrogen-stimulated signaling through PRKCZ"/>
            <pathway-xref db="Reactome" id="R-MMU-3214858" name="RMTs methylate histone arginines"/>
            <pathway-xref db="Reactome" id="R-CEL-8878166" name="Transcriptional regulation by RUNX2"/>
            <pathway-xref db="Reactome" id="R-DME-216217" name="Activation of SMO"/>
            <pathway-xref db="Reactome" id="R-HSA-9680187" name="Signaling by extracellular domain mutants of KIT"/>
            <pathway-xref db="Reactome" id="R-HSA-9034793" name="Activated NTRK3 signals through PLCG1"/>
            <pathway-xref db="Reactome" id="R-HSA-9662834" name="CD163 mediating an anti-inflammatory response"/>
            <pathway-xref db="Reactome" id="R-RNO-2559582" name="Senescence-Associated Secretory Phenotype (SASP)"/>
            <pathway-xref db="Reactome" id="R-DRE-8854691" name="Interleukin-20 family signaling"/>
            <pathway-xref db="Reactome" id="R-GGA-2029481" name="FCGR activation"/>
            <pathway-xref db="Reactome" id="R-RNO-8853659" name="RET signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9013957" name="TLR3-mediated TICAM1-dependent programmed cell death"/>
            <pathway-xref db="Reactome" id="R-DME-112409" name="RAF-independent MAPK1/3 activation"/>
            <pathway-xref db="Reactome" id="R-DDI-204005" name="COPII-mediated vesicle transport"/>
            <pathway-xref db="Reactome" id="R-MMU-392451" name="G beta:gamma signalling through PI3Kgamma"/>
            <pathway-xref db="Reactome" id="R-DRE-2871837" name="FCERI mediated NF-kB activation"/>
            <pathway-xref db="Reactome" id="R-SCE-2871837" name="FCERI mediated NF-kB activation"/>
            <pathway-xref db="Reactome" id="R-MMU-5205685" name="PINK1-PRKN Mediated Mitophagy"/>
            <pathway-xref db="Reactome" id="R-RNO-5687128" name="MAPK6/MAPK4 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-3899300" name="SUMOylation of transcription cofactors"/>
            <pathway-xref db="Reactome" id="R-SPO-9018519" name="Estrogen-dependent gene expression"/>
            <pathway-xref db="Reactome" id="R-CEL-168638" name="NOD1/2 Signaling Pathway"/>
            <pathway-xref db="Reactome" id="R-XTR-6796648" name="TP53 Regulates Transcription of DNA Repair Genes"/>
            <pathway-xref db="Reactome" id="R-HSA-69478" name="G2/M DNA replication checkpoint"/>
            <pathway-xref db="Reactome" id="R-DDI-5674135" name="MAP2K and MAPK activation"/>
            <pathway-xref db="Reactome" id="R-MMU-176187" name="Activation of ATR in response to replication stress"/>
            <pathway-xref db="Reactome" id="R-MMU-9627069" name="Regulation of the apoptosome activity"/>
            <pathway-xref db="Reactome" id="R-RNO-8851805" name="MET activates RAS signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-216083" name="Integrin cell surface interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-399954" name="Sema3A PAK dependent Axon repulsion"/>
            <pathway-xref db="Reactome" id="R-RNO-1170546" name="Prolactin receptor signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-450604" name="KSRP (KHSRP) binds and destabilizes mRNA"/>
            <pathway-xref db="Reactome" id="R-DME-451806" name="Phosphorylation-independent inhibition of YKI"/>
            <pathway-xref db="Reactome" id="R-HSA-8939902" name="Regulation of RUNX2 expression and activity"/>
            <pathway-xref db="Reactome" id="R-SCE-114508" name="Effects of PIP2 hydrolysis"/>
            <pathway-xref db="Reactome" id="R-CEL-199920" name="CREB phosphorylation"/>
            <pathway-xref db="Reactome" id="R-BTA-3928663" name="EPHA-mediated growth cone collapse"/>
            <pathway-xref db="Reactome" id="R-HSA-392517" name="Rap1 signalling"/>
            <pathway-xref db="Reactome" id="R-RNO-1250342" name="PI3K events in ERBB4 signaling"/>
            <pathway-xref db="Reactome" id="R-DDI-6807505" name="RNA polymerase II transcribes snRNA genes"/>
            <pathway-xref db="Reactome" id="R-SPO-112409" name="RAF-independent MAPK1/3 activation"/>
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            <pathway-xref db="Reactome" id="R-DRE-6783783" name="Interleukin-10 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-6804116" name="TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest"/>
            <pathway-xref db="Reactome" id="R-SPO-450302" name="activated TAK1 mediates p38 MAPK activation"/>
            <pathway-xref db="Reactome" id="R-MMU-354194" name="GRB2:SOS provides linkage to MAPK signaling for Integrins"/>
            <pathway-xref db="Reactome" id="R-DME-69563" name="p53-Dependent G1 DNA Damage Response"/>
            <pathway-xref db="Reactome" id="R-DRE-2559580" name="Oxidative Stress Induced Senescence"/>
            <pathway-xref db="Reactome" id="R-DME-5654227" name="Phospholipase C-mediated cascade, FGFR3"/>
            <pathway-xref db="Reactome" id="R-HSA-1839128" name="FGFR4 mutant receptor activation"/>
            <pathway-xref db="Reactome" id="R-MMU-9652282" name="Drug-mediated inhibition of ERBB2 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-186763" name="Downstream signal transduction"/>
            <pathway-xref db="Reactome" id="R-HSA-9683610" name="Maturation of nucleoprotein"/>
            <pathway-xref db="Reactome" id="R-CEL-5663213" name="RHO GTPases Activate WASPs and WAVEs"/>
            <pathway-xref db="Reactome" id="R-GGA-1227739" name="Caspase-8 and -10 mediated induction of NF-kB"/>
            <pathway-xref db="Reactome" id="R-DRE-936837" name="Ion transport by P-type ATPases"/>
            <pathway-xref db="Reactome" id="R-CEL-8964616" name="G beta:gamma signalling through CDC42"/>
            <pathway-xref db="Reactome" id="R-RNO-5654726" name="Negative regulation of FGFR1 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-380259" name="Loss of Nlp from mitotic centrosomes"/>
            <pathway-xref db="Reactome" id="R-DME-912631" name="Regulation of signaling by CBL"/>
            <pathway-xref db="Reactome" id="R-HSA-9018519" name="Estrogen-dependent gene expression"/>
            <pathway-xref db="Reactome" id="R-CEL-75035" name="Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex"/>
            <pathway-xref db="Reactome" id="R-SCE-5668541" name="TNFR2 non-canonical NF-kB pathway"/>
            <pathway-xref db="Reactome" id="R-RNO-180024" name="DARPP-32 events"/>
            <pathway-xref db="Reactome" id="R-DDI-165158" name="Activation of AKT2"/>
            <pathway-xref db="Reactome" id="R-HSA-1059683" name="Interleukin-6 signaling"/>
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            <pathway-xref db="Reactome" id="R-MMU-9013407" name="RHOH GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-6811558" name="PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-354194" name="GRB2:SOS provides linkage to MAPK signaling for Integrins"/>
            <pathway-xref db="Reactome" id="R-SPO-432142" name="Platelet sensitization by LDL"/>
            <pathway-xref db="Reactome" id="R-HSA-418555" name="G alpha (s) signalling events"/>
            <pathway-xref db="Reactome" id="R-SSC-8854521" name="Interaction between PHLDA1 and AURKA"/>
            <pathway-xref db="Reactome" id="R-DRE-5620912" name="Anchoring of the basal body to the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-RNO-8851907" name="MET activates PI3K/AKT signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9702605" name="pexidartinib-resistant FLT3 mutants"/>
            <pathway-xref db="Reactome" id="R-DME-209155" name="Phosphorylation of AXN and APC"/>
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            <pathway-xref db="Reactome" id="R-SCE-881907" name="Gastrin-CREB signalling pathway via PKC and MAPK"/>
            <pathway-xref db="Reactome" id="R-RNO-877300" name="Interferon gamma signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-2682334" name="EPH-Ephrin signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-5627123" name="RHO GTPases activate PAKs"/>
            <pathway-xref db="Reactome" id="R-RNO-113418" name="Formation of the Early Elongation Complex"/>
            <pathway-xref db="Reactome" id="R-RNO-2672351" name="Stimuli-sensing channels"/>
            <pathway-xref db="Reactome" id="R-RNO-437239" name="Recycling pathway of L1"/>
            <pathway-xref db="Reactome" id="R-RNO-76042" name="RNA Polymerase II Transcription Initiation And Promoter Clearance"/>
            <pathway-xref db="Reactome" id="R-MMU-399997" name="Acetylcholine regulates insulin secretion"/>
            <pathway-xref db="Reactome" id="R-DME-9027276" name="Erythropoietin activates Phosphoinositide-3-kinase (PI3K)"/>
            <pathway-xref db="Reactome" id="R-DME-9020558" name="Interleukin-2 signaling"/>
            <pathway-xref db="Reactome" id="R-DME-5689896" name="Ovarian tumor domain proteases"/>
            <pathway-xref db="Reactome" id="R-MMU-2029482" name="Regulation of actin dynamics for phagocytic cup formation"/>
            <pathway-xref db="Reactome" id="R-MMU-975871" name="MyD88 cascade initiated on plasma membrane"/>
            <pathway-xref db="Reactome" id="R-HSA-1433557" name="Signaling by SCF-KIT"/>
            <pathway-xref db="Reactome" id="R-RNO-9013148" name="CDC42 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-444257" name="RSK activation"/>
            <pathway-xref db="Reactome" id="R-DME-445144" name="Signal transduction by L1"/>
            <pathway-xref db="Reactome" id="R-HSA-937042" name="IRAK2 mediated activation of TAK1 complex"/>
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            <pathway-xref db="Reactome" id="R-RNO-114604" name="GPVI-mediated activation cascade"/>
            <pathway-xref db="Reactome" id="R-MMU-2995383" name="Initiation of Nuclear Envelope (NE) Reformation"/>
            <pathway-xref db="Reactome" id="R-DME-110056" name="MAPK3 (ERK1) activation"/>
            <pathway-xref db="Reactome" id="R-HSA-9694686" name="Replication of the SARS-CoV-2 genome"/>
            <pathway-xref db="Reactome" id="R-HSA-8853884" name="Transcriptional Regulation by VENTX"/>
            <pathway-xref db="Reactome" id="R-DRE-4615885" name="SUMOylation of DNA replication proteins"/>
            <pathway-xref db="Reactome" id="R-DME-1474151" name="Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation"/>
            <pathway-xref db="Reactome" id="R-SPO-198323" name="AKT phosphorylates targets in the cytosol"/>
            <pathway-xref db="Reactome" id="R-BTA-389513" name="CTLA4 inhibitory signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9656223" name="Signaling by RAF1 mutants"/>
            <pathway-xref db="Reactome" id="R-CEL-9013406" name="RHOQ GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-112411" name="MAPK1 (ERK2) activation"/>
            <pathway-xref db="Reactome" id="R-RNO-446388" name="Regulation of cytoskeletal remodeling and cell spreading by IPP complex components"/>
            <pathway-xref db="Reactome" id="R-BTA-4420097" name="VEGFA-VEGFR2 Pathway"/>
            <pathway-xref db="Reactome" id="R-HSA-5655291" name="Signaling by FGFR4 in disease"/>
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            <pathway-xref db="Reactome" id="R-MMU-933542" name="TRAF6 mediated NF-kB activation"/>
            <pathway-xref db="Reactome" id="R-GGA-5687128" name="MAPK6/MAPK4 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9664422" name="FCGR3A-mediated phagocytosis"/>
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            <pathway-xref db="Reactome" id="R-HSA-881907" name="Gastrin-CREB signalling pathway via PKC and MAPK"/>
            <pathway-xref db="Reactome" id="R-BTA-69231" name="Cyclin D associated events in G1"/>
            <pathway-xref db="Reactome" id="R-SCE-112411" name="MAPK1 (ERK2) activation"/>
            <pathway-xref db="Reactome" id="R-SPO-6782135" name="Dual incision in TC-NER"/>
            <pathway-xref db="Reactome" id="R-MMU-512988" name="Interleukin-3, Interleukin-5 and GM-CSF signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-8866376" name="Reelin signalling pathway"/>
            <pathway-xref db="Reactome" id="R-DME-5654699" name="SHC-mediated cascade:FGFR2"/>
            <pathway-xref db="Reactome" id="R-MMU-6814122" name="Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"/>
            <pathway-xref db="Reactome" id="R-CEL-9013405" name="RHOD GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-5654733" name="Negative regulation of FGFR4 signaling"/>
            <pathway-xref db="Reactome" id="R-PFA-381676" name="Glucagon-like Peptide-1 (GLP1) regulates insulin secretion"/>
            <pathway-xref db="Reactome" id="R-HSA-176417" name="Phosphorylation of Emi1"/>
            <pathway-xref db="Reactome" id="R-MMU-170984" name="ARMS-mediated activation"/>
            <pathway-xref db="Reactome" id="R-SCE-9013406" name="RHOQ GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-5674499" name="Negative feedback regulation of MAPK pathway"/>
            <pathway-xref db="Reactome" id="R-HSA-1251985" name="Nuclear signaling by ERBB4"/>
            <pathway-xref db="Reactome" id="R-MMU-5607761" name="Dectin-1 mediated noncanonical NF-kB signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-9020591" name="Interleukin-12 signaling"/>
            <pathway-xref db="Reactome" id="R-GGA-418592" name="ADP signalling through P2Y purinoceptor 1"/>
            <pathway-xref db="Reactome" id="R-RNO-380284" name="Loss of proteins required for interphase microtubule organization from the centrosome"/>
            <pathway-xref db="Reactome" id="R-RNO-1251985" name="Nuclear signaling by ERBB4"/>
            <pathway-xref db="Reactome" id="R-CEL-69478" name="G2/M DNA replication checkpoint"/>
            <pathway-xref db="Reactome" id="R-HSA-6802955" name="Paradoxical activation of RAF signaling by kinase inactive BRAF"/>
            <pathway-xref db="Reactome" id="R-HSA-3371571" name="HSF1-dependent transactivation"/>
            <pathway-xref db="Reactome" id="R-DDI-8963896" name="HDL assembly"/>
            <pathway-xref db="Reactome" id="R-MMU-9674555" name="Signaling by CSF3 (G-CSF)"/>
            <pathway-xref db="Reactome" id="R-DDI-1257604" name="PIP3 activates AKT signaling"/>
            <pathway-xref db="Reactome" id="R-DRE-375165" name="NCAM signaling for neurite out-growth"/>
            <pathway-xref db="Reactome" id="R-MMU-416476" name="G alpha (q) signalling events"/>
            <pathway-xref db="Reactome" id="R-MMU-5654706" name="FRS-mediated FGFR3 signaling"/>
            <pathway-xref db="Reactome" id="R-CEL-4420097" name="VEGFA-VEGFR2 Pathway"/>
            <pathway-xref db="Reactome" id="R-MMU-6782210" name="Gap-filling DNA repair synthesis and ligation in TC-NER"/>
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            <pathway-xref db="Reactome" id="R-SCE-176187" name="Activation of ATR in response to replication stress"/>
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            <pathway-xref db="Reactome" id="R-MMU-171007" name="p38MAPK events"/>
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            <pathway-xref db="Reactome" id="R-DME-2454202" name="Fc epsilon receptor (FCERI) signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-204005" name="COPII-mediated vesicle transport"/>
            <pathway-xref db="Reactome" id="R-CEL-186763" name="Downstream signal transduction"/>
            <pathway-xref db="Reactome" id="R-MMU-8875656" name="MET receptor recycling"/>
            <pathway-xref db="Reactome" id="R-BTA-6796648" name="TP53 Regulates Transcription of DNA Repair Genes"/>
            <pathway-xref db="Reactome" id="R-DRE-8854518" name="AURKA Activation by TPX2"/>
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            <pathway-xref db="Reactome" id="R-MMU-76042" name="RNA Polymerase II Transcription Initiation And Promoter Clearance"/>
            <pathway-xref db="Reactome" id="R-MMU-418457" name="cGMP effects"/>
            <pathway-xref db="Reactome" id="R-HSA-354192" name="Integrin signaling"/>
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            <pathway-xref db="Reactome" id="R-DME-209387" name="Phosphorylation of ARR"/>
            <pathway-xref db="Reactome" id="R-SPO-163680" name="AMPK inhibits chREBP transcriptional activation activity"/>
            <pathway-xref db="Reactome" id="R-RNO-75035" name="Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex"/>
            <pathway-xref db="Reactome" id="R-HSA-1236974" name="ER-Phagosome pathway"/>
            <pathway-xref db="Reactome" id="R-HSA-77387" name="Insulin receptor recycling"/>
            <pathway-xref db="Reactome" id="R-RNO-1483191" name="Synthesis of PC"/>
            <pathway-xref db="Reactome" id="R-MMU-2428928" name="IRS-related events triggered by IGF1R"/>
            <pathway-xref db="Reactome" id="R-DME-69601" name="Ubiquitin Mediated Degradation of Phosphorylated Cdc25A"/>
            <pathway-xref db="Reactome" id="R-BTA-674695" name="RNA Polymerase II Pre-transcription Events"/>
            <pathway-xref db="Reactome" id="R-DRE-430116" name="GP1b-IX-V activation signalling"/>
            <pathway-xref db="Reactome" id="R-DRE-2682334" name="EPH-Ephrin signaling"/>
            <pathway-xref db="Reactome" id="R-SPO-110056" name="MAPK3 (ERK1) activation"/>
            <pathway-xref db="Reactome" id="R-SCE-392451" name="G beta:gamma signalling through PI3Kgamma"/>
            <pathway-xref db="Reactome" id="R-HSA-9020933" name="Interleukin-23 signaling"/>
            <pathway-xref db="Reactome" id="R-DDI-2028269" name="Signaling by Hippo"/>
            <pathway-xref db="Reactome" id="R-MMU-399954" name="Sema3A PAK dependent Axon repulsion"/>
            <pathway-xref db="Reactome" id="R-DDI-176412" name="Phosphorylation of the APC/C"/>
            <pathway-xref db="Reactome" id="R-HSA-1445148" name="Translocation of SLC2A4 (GLUT4) to the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-RNO-2404192" name="Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)"/>
            <pathway-xref db="Reactome" id="R-GGA-191650" name="Regulation of gap junction activity"/>
            <pathway-xref db="Reactome" id="R-DME-77387" name="Insulin receptor recycling"/>
            <pathway-xref db="Reactome" id="R-DME-5654710" name="PI-3K cascade:FGFR3"/>
            <pathway-xref db="Reactome" id="R-HSA-9682706" name="Replication of the SARS-CoV-1 genome"/>
            <pathway-xref db="Reactome" id="R-RNO-1236394" name="Signaling by ERBB4"/>
            <pathway-xref db="Reactome" id="R-SCE-2871796" name="FCERI mediated MAPK activation"/>
            <pathway-xref db="Reactome" id="R-DRE-210993" name="Tie2 Signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-8963896" name="HDL assembly"/>
            <pathway-xref db="Reactome" id="R-HSA-5654732" name="Negative regulation of FGFR3 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-111447" name="Activation of BAD and translocation to mitochondria"/>
            <pathway-xref db="Reactome" id="R-HSA-5339716" name="Signaling by GSK3beta mutants"/>
            <pathway-xref db="Reactome" id="R-HSA-9669933" name="Signaling by kinase domain mutants of KIT"/>
            <pathway-xref db="Reactome" id="R-RNO-4615885" name="SUMOylation of DNA replication proteins"/>
            <pathway-xref db="Reactome" id="R-HSA-2871809" name="FCERI mediated Ca+2 mobilization"/>
            <pathway-xref db="Reactome" id="R-HSA-9645460" name="Alpha-protein kinase 1 signaling pathway"/>
            <pathway-xref db="Reactome" id="R-SCE-5607761" name="Dectin-1 mediated noncanonical NF-kB signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-9013406" name="RHOQ GTPase cycle"/>
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            <pathway-xref db="Reactome" id="R-HSA-9702518" name="STAT5 activation downstream of FLT3 ITD mutants"/>
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            <pathway-xref db="Reactome" id="R-HSA-9630791" name="Evasion of Oncogene Induced Senescence Due to Defective p16INK4A binding to CDK4"/>
            <pathway-xref db="Reactome" id="R-HSA-6804758" name="Regulation of TP53 Activity through Acetylation"/>
            <pathway-xref db="Reactome" id="R-RNO-202424" name="Downstream TCR signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-68884" name="Mitotic Telophase/Cytokinesis"/>
            <pathway-xref db="Reactome" id="R-DME-450302" name="activated TAK1 mediates p38 MAPK activation"/>
            <pathway-xref db="Reactome" id="R-DME-174178" name="APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1"/>
            <pathway-xref db="Reactome" id="R-RNO-177929" name="Signaling by EGFR"/>
            <pathway-xref db="Reactome" id="R-HSA-380284" name="Loss of proteins required for interphase microtubule organization from the centrosome"/>
            <pathway-xref db="Reactome" id="R-RNO-442742" name="CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-982772" name="Growth hormone receptor signaling"/>
            <pathway-xref db="Reactome" id="R-DME-525793" name="Myogenesis"/>
            <pathway-xref db="Reactome" id="R-DDI-203615" name="eNOS activation"/>
            <pathway-xref db="Reactome" id="R-GGA-451478" name="ERK activation"/>
            <pathway-xref db="Reactome" id="R-MMU-5693607" name="Processing of DNA double-strand break ends"/>
            <pathway-xref db="Reactome" id="R-DRE-75035" name="Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex"/>
            <pathway-xref db="Reactome" id="R-DME-5693616" name="Presynaptic phase of homologous DNA pairing and strand exchange"/>
            <pathway-xref db="Reactome" id="R-MMU-69478" name="G2/M DNA replication checkpoint"/>
            <pathway-xref db="Reactome" id="R-DRE-1251985" name="Nuclear signaling by ERBB4"/>
            <pathway-xref db="Reactome" id="R-DRE-912694" name="Regulation of IFNA signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-380270" name="Recruitment of mitotic centrosome proteins and complexes"/>
            <pathway-xref db="Reactome" id="R-HSA-9673768" name="Signaling by membrane-tethered fusions of PDGFRA or PDGFRB"/>
            <pathway-xref db="Reactome" id="R-SSC-69231" name="Cyclin D associated events in G1"/>
            <pathway-xref db="Reactome" id="R-MMU-881907" name="Gastrin-CREB signalling pathway via PKC and MAPK"/>
            <pathway-xref db="Reactome" id="R-CEL-1433559" name="Regulation of KIT signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-2424491" name="DAP12 signaling"/>
            <pathway-xref db="Reactome" id="R-BTA-210990" name="PECAM1 interactions"/>
            <pathway-xref db="Reactome" id="R-RNO-389948" name="PD-1 signaling"/>
            <pathway-xref db="Reactome" id="R-DME-174048" name="APC/C:Cdc20 mediated degradation of Cyclin B"/>
            <pathway-xref db="Reactome" id="R-MMU-975163" name="IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation"/>
            <pathway-xref db="Reactome" id="R-CEL-8934593" name="Regulation of RUNX1 Expression and Activity"/>
            <pathway-xref db="Reactome" id="R-MMU-4086398" name="Ca2+ pathway"/>
            <pathway-xref db="Reactome" id="R-GGA-2730905" name="Role of LAT2/NTAL/LAB on calcium mobilization"/>
            <pathway-xref db="Reactome" id="R-DME-2028269" name="Signaling by Hippo"/>
            <pathway-xref db="Reactome" id="R-RNO-6804116" name="TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest"/>
            <pathway-xref db="Reactome" id="R-HSA-180292" name="GAB1 signalosome"/>
            <pathway-xref db="Reactome" id="R-MMU-392517" name="Rap1 signalling"/>
            <pathway-xref db="Reactome" id="R-RNO-176408" name="Regulation of APC/C activators between G1/S and early anaphase"/>
            <pathway-xref db="Reactome" id="R-MMU-68875" name="Mitotic Prophase"/>
            <pathway-xref db="Reactome" id="R-DRE-5654219" name="Phospholipase C-mediated cascade: FGFR1"/>
            <pathway-xref db="Reactome" id="R-CEL-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DME-6804756" name="Regulation of TP53 Activity through Phosphorylation"/>
            <pathway-xref db="Reactome" id="R-DRE-399956" name="CRMPs in Sema3A signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-8984722" name="Interleukin-35 Signalling"/>
            <pathway-xref db="Reactome" id="R-DRE-171007" name="p38MAPK events"/>
            <pathway-xref db="Reactome" id="R-HSA-9031628" name="NGF-stimulated transcription"/>
            <pathway-xref db="Reactome" id="R-CEL-2173789" name="TGF-beta receptor signaling activates SMADs"/>
            <pathway-xref db="Reactome" id="R-RNO-9648002" name="RAS processing"/>
            <pathway-xref db="Reactome" id="R-HSA-1810476" name="RIP-mediated NFkB activation via ZBP1"/>
            <pathway-xref db="Reactome" id="R-MMU-5357956" name="TNFR1-induced NFkappaB signaling pathway"/>
            <pathway-xref db="Reactome" id="R-HSA-5654227" name="Phospholipase C-mediated cascade, FGFR3"/>
            <pathway-xref db="Reactome" id="R-DME-450513" name="Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA"/>
            <pathway-xref db="Reactome" id="R-DRE-2565942" name="Regulation of PLK1 Activity at G2/M Transition"/>
            <pathway-xref db="Reactome" id="R-MMU-1912408" name="Pre-NOTCH Transcription and Translation"/>
            <pathway-xref db="Reactome" id="R-DME-209360" name="Ubiquitination and proteolysis of phosphorylated CI"/>
            <pathway-xref db="Reactome" id="R-SSC-3928662" name="EPHB-mediated forward signaling"/>
            <pathway-xref db="Reactome" id="R-DME-3371571" name="HSF1-dependent transactivation"/>
            <pathway-xref db="Reactome" id="R-MMU-5635838" name="Activation of SMO"/>
            <pathway-xref db="Reactome" id="R-MMU-1660499" name="Synthesis of PIPs at the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-RNO-983231" name="Factors involved in megakaryocyte development and platelet production"/>
            <pathway-xref db="Reactome" id="R-SCE-5673001" name="RAF/MAP kinase cascade"/>
            <pathway-xref db="Reactome" id="R-DRE-1253288" name="Downregulation of ERBB4 signaling"/>
            <pathway-xref db="Reactome" id="R-SPO-2871796" name="FCERI mediated MAPK activation"/>
            <pathway-xref db="Reactome" id="R-DDI-381042" name="PERK regulates gene expression"/>
            <pathway-xref db="Reactome" id="R-MMU-354192" name="Integrin signaling"/>
            <pathway-xref db="Reactome" id="R-SCE-450341" name="Activation of the AP-1 family of transcription factors"/>
            <pathway-xref db="Reactome" id="R-DME-1257604" name="PIP3 activates AKT signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-391160" name="Signal regulatory protein family interactions"/>
            <pathway-xref db="Reactome" id="R-DDI-69231" name="Cyclin D associated events in G1"/>
            <pathway-xref db="Reactome" id="R-CEL-9013149" name="RAC1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-3769402" name="Deactivation of the beta-catenin transactivating complex"/>
            <pathway-xref db="Reactome" id="R-HSA-5625740" name="RHO GTPases activate PKNs"/>
            <pathway-xref db="Reactome" id="R-DME-1433557" name="Signaling by SCF-KIT"/>
            <pathway-xref db="Reactome" id="R-HSA-9694631" name="Maturation of nucleoprotein"/>
            <pathway-xref db="Reactome" id="R-RNO-877312" name="Regulation of IFNG signaling"/>
            <pathway-xref db="Reactome" id="R-SPO-674695" name="RNA Polymerase II Pre-transcription Events"/>
            <pathway-xref db="Reactome" id="R-HSA-5603029" name="IkBA variant leads to EDA-ID"/>
            <pathway-xref db="Reactome" id="R-DRE-3928662" name="EPHB-mediated forward signaling"/>
            <pathway-xref db="Reactome" id="R-SSC-3928664" name="Ephrin signaling"/>
            <pathway-xref db="Reactome" id="R-CEL-8953750" name="Transcriptional Regulation by E2F6"/>
            <pathway-xref db="Reactome" id="R-HSA-9020558" name="Interleukin-2 signaling"/>
            <pathway-xref db="Reactome" id="R-DME-198753" name="ERK/MAPK targets"/>
            <pathway-xref db="Reactome" id="R-RNO-3928664" name="Ephrin signaling"/>
            <pathway-xref db="Reactome" id="R-GGA-354194" name="GRB2:SOS provides linkage to MAPK signaling for Integrins"/>
            <pathway-xref db="Reactome" id="R-SPO-2871837" name="FCERI mediated NF-kB activation"/>
            <pathway-xref db="Reactome" id="R-HSA-168638" name="NOD1/2 Signaling Pathway"/>
            <pathway-xref db="Reactome" id="R-RNO-8854691" name="Interleukin-20 family signaling"/>
            <pathway-xref db="Reactome" id="R-GGA-195253" name="Degradation of beta-catenin by the destruction complex"/>
            <pathway-xref db="Reactome" id="R-HSA-1181150" name="Signaling by NODAL"/>
            <pathway-xref db="Reactome" id="R-DME-8941858" name="Regulation of RUNX3 expression and activity"/>
            <pathway-xref db="Reactome" id="R-DRE-1169408" name="ISG15 antiviral mechanism"/>
            <pathway-xref db="Reactome" id="R-DDI-198693" name="AKT phosphorylates targets in the nucleus"/>
            <pathway-xref db="Reactome" id="R-CEL-3928663" name="EPHA-mediated growth cone collapse"/>
            <pathway-xref db="Reactome" id="R-MMU-2559582" name="Senescence-Associated Secretory Phenotype (SASP)"/>
            <pathway-xref db="Reactome" id="R-SSC-5673001" name="RAF/MAP kinase cascade"/>
            <pathway-xref db="Reactome" id="R-MMU-936837" name="Ion transport by P-type ATPases"/>
            <pathway-xref db="Reactome" id="R-HSA-373760" name="L1CAM interactions"/>
            <pathway-xref db="Reactome" id="R-MMU-202433" name="Generation of second messenger molecules"/>
            <pathway-xref db="Reactome" id="R-SPO-114516" name="Disinhibition of SNARE formation"/>
            <pathway-xref db="Reactome" id="R-MMU-3928663" name="EPHA-mediated growth cone collapse"/>
            <pathway-xref db="Reactome" id="R-MMU-73776" name="RNA Polymerase II Promoter Escape"/>
            <pathway-xref db="Reactome" id="R-DME-209413" name="Assembly of the 'destruction complex'"/>
            <pathway-xref db="Reactome" id="R-HSA-5654710" name="PI-3K cascade:FGFR3"/>
            <pathway-xref db="Reactome" id="R-HSA-1295596" name="Spry regulation of FGF signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-1502540" name="Signaling by Activin"/>
            <pathway-xref db="Reactome" id="R-DME-3301854" name="Nuclear Pore Complex (NPC) Disassembly"/>
            <pathway-xref db="Reactome" id="R-CEL-2500257" name="Resolution of Sister Chromatid Cohesion"/>
            <pathway-xref db="Reactome" id="R-DDI-5673000" name="RAF activation"/>
            <pathway-xref db="Reactome" id="R-RNO-190374" name="FGFR1c and Klotho ligand binding and activation"/>
            <pathway-xref db="Reactome" id="R-DRE-195399" name="VEGF binds to VEGFR leading to receptor dimerization"/>
            <pathway-xref db="Reactome" id="R-GGA-186763" name="Downstream signal transduction"/>
            <pathway-xref db="Reactome" id="R-BTA-389359" name="CD28 dependent Vav1 pathway"/>
            <pathway-xref db="Reactome" id="R-DME-2871809" name="FCERI mediated Ca+2 mobilization"/>
            <pathway-xref db="Reactome" id="R-DME-202670" name="ERKs are inactivated"/>
            <pathway-xref db="Reactome" id="R-RNO-3928662" name="EPHB-mediated forward signaling"/>
            <pathway-xref db="Reactome" id="R-DME-209397" name="Formation of the cytosolic BSK 'scaffolding complex'"/>
            <pathway-xref db="Reactome" id="R-DME-5140745" name="WNT5A-dependent internalization of FZD2, FZD5 and ROR2"/>
            <pathway-xref db="Reactome" id="R-HSA-2871837" name="FCERI mediated NF-kB activation"/>
            <pathway-xref db="Reactome" id="R-HSA-1266695" name="Interleukin-7 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-74713" name="IRS activation"/>
            <pathway-xref db="Reactome" id="R-SSC-936837" name="Ion transport by P-type ATPases"/>
            <pathway-xref db="Reactome" id="R-CEL-392517" name="Rap1 signalling"/>
            <pathway-xref db="Reactome" id="R-DRE-389357" name="CD28 dependent PI3K/Akt signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-9027284" name="Erythropoietin activates RAS"/>
            <pathway-xref db="Reactome" id="R-HSA-432040" name="Vasopressin regulates renal water homeostasis via Aquaporins"/>
            <pathway-xref db="Reactome" id="R-CEL-375165" name="NCAM signaling for neurite out-growth"/>
            <pathway-xref db="Reactome" id="R-DDI-5675221" name="Negative regulation of MAPK pathway"/>
            <pathway-xref db="Reactome" id="R-RNO-72086" name="mRNA Capping"/>
            <pathway-xref db="Reactome" id="R-SPO-68884" name="Mitotic Telophase/Cytokinesis"/>
            <pathway-xref db="Reactome" id="R-SCE-141430" name="Inactivation of APC/C via direct inhibition of the APC/C complex"/>
            <pathway-xref db="Reactome" id="R-GGA-2029485" name="Role of phospholipids in phagocytosis"/>
            <pathway-xref db="Reactome" id="R-MMU-9013422" name="RHOBTB1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-CEL-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-RNO-445355" name="Smooth Muscle Contraction"/>
            <pathway-xref db="Reactome" id="R-HSA-169131" name="Inhibition of PKR"/>
            <pathway-xref db="Reactome" id="R-DDI-9031628" name="NGF-stimulated transcription"/>
            <pathway-xref db="Reactome" id="R-HSA-165181" name="Inhibition of TSC complex formation by PKB"/>
            <pathway-xref db="Reactome" id="R-SPO-5607764" name="CLEC7A (Dectin-1) signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-5663220" name="RHO GTPases Activate Formins"/>
            <pathway-xref db="Reactome" id="R-RNO-9706369" name="Negative regulation of FLT3"/>
            <pathway-xref db="Reactome" id="R-CEL-1912408" name="Pre-NOTCH Transcription and Translation"/>
            <pathway-xref db="Reactome" id="R-SPO-2559580" name="Oxidative Stress Induced Senescence"/>
            <pathway-xref db="Reactome" id="R-RNO-201688" name="WNT mediated activation of DVL"/>
            <pathway-xref db="Reactome" id="R-HSA-427413" name="NoRC negatively regulates rRNA expression"/>
            <pathway-xref db="Reactome" id="R-SPO-176187" name="Activation of ATR in response to replication stress"/>
            <pathway-xref db="Reactome" id="R-SPO-392451" name="G beta:gamma signalling through PI3Kgamma"/>
            <pathway-xref db="Reactome" id="R-CEL-5687128" name="MAPK6/MAPK4 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-190371" name="FGFR3b ligand binding and activation"/>
            <pathway-xref db="Reactome" id="R-HSA-449836" name="Other interleukin signaling"/>
            <pathway-xref db="Reactome" id="R-DME-9018519" name="Estrogen-dependent gene expression"/>
            <pathway-xref db="Reactome" id="R-SPO-6804758" name="Regulation of TP53 Activity through Acetylation"/>
            <pathway-xref db="Reactome" id="R-RNO-8939211" name="ESR-mediated signaling"/>
            <pathway-xref db="Reactome" id="R-DME-5654687" name="Downstream signaling of activated FGFR1"/>
            <pathway-xref db="Reactome" id="R-MMU-5099900" name="WNT5A-dependent internalization of FZD4"/>
            <pathway-xref db="Reactome" id="R-SCE-5674135" name="MAP2K and MAPK activation"/>
            <pathway-xref db="Reactome" id="R-CEL-2559582" name="Senescence-Associated Secretory Phenotype (SASP)"/>
            <pathway-xref db="Reactome" id="R-HSA-2894862" name="Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants"/>
            <pathway-xref db="Reactome" id="R-RNO-68881" name="Mitotic Metaphase/Anaphase Transition"/>
            <pathway-xref db="Reactome" id="R-HSA-380320" name="Recruitment of NuMA to mitotic centrosomes"/>
            <pathway-xref db="Reactome" id="R-DRE-933542" name="TRAF6 mediated NF-kB activation"/>
            <pathway-xref db="Reactome" id="R-SCE-200425" name="Carnitine metabolism"/>
            <pathway-xref db="Reactome" id="R-HSA-9025046" name="NTF3 activates NTRK2 (TRKB) signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-171319" name="Telomere Extension By Telomerase"/>
            <pathway-xref db="Reactome" id="R-HSA-77075" name="RNA Pol II CTD phosphorylation and interaction with CE"/>
            <pathway-xref db="Reactome" id="R-HSA-446388" name="Regulation of cytoskeletal remodeling and cell spreading by IPP complex components"/>
            <pathway-xref db="Reactome" id="R-MMU-9603381" name="Activated NTRK3 signals through PI3K"/>
            <pathway-xref db="Reactome" id="R-CEL-73776" name="RNA Polymerase II Promoter Escape"/>
            <pathway-xref db="Reactome" id="R-DRE-3928664" name="Ephrin signaling"/>
            <pathway-xref db="Reactome" id="R-CEL-9013424" name="RHOV GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-165158" name="Activation of AKT2"/>
            <pathway-xref db="Reactome" id="R-CEL-196299" name="Beta-catenin phosphorylation cascade"/>
            <pathway-xref db="Reactome" id="R-SPO-6804757" name="Regulation of TP53 Degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-9013423" name="RAC3 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-SSC-2565942" name="Regulation of PLK1 Activity at G2/M Transition"/>
            <pathway-xref db="Reactome" id="R-RNO-5213460" name="RIPK1-mediated regulated necrosis"/>
            <pathway-xref db="Reactome" id="R-SSC-2559585" name="Oncogene Induced Senescence"/>
            <pathway-xref db="Reactome" id="R-HSA-167287" name="HIV elongation arrest and recovery"/>
            <pathway-xref db="Reactome" id="R-CEL-164378" name="PKA activation in glucagon signalling"/>
            <pathway-xref db="Reactome" id="R-RNO-9604323" name="Negative regulation of NOTCH4 signaling"/>
            <pathway-xref db="Reactome" id="R-DDI-6804757" name="Regulation of TP53 Degradation"/>
            <pathway-xref db="Reactome" id="R-RNO-73863" name="RNA Polymerase I Transcription Termination"/>
            <pathway-xref db="Reactome" id="R-MMU-937039" name="IRAK1 recruits IKK complex"/>
            <pathway-xref db="Reactome" id="R-RNO-9013106" name="RHOC GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-8875555" name="MET activates RAP1 and RAC1"/>
            <pathway-xref db="Reactome" id="R-RNO-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-MMU-8953750" name="Transcriptional Regulation by E2F6"/>
            <pathway-xref db="Reactome" id="R-SSC-2980767" name="Activation of NIMA Kinases NEK9, NEK6, NEK7"/>
            <pathway-xref db="Reactome" id="R-DRE-5654693" name="FRS-mediated FGFR1 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-9013420" name="RHOU GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-9013149" name="RAC1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-SPO-2514853" name="Condensation of Prometaphase Chromosomes"/>
            <pathway-xref db="Reactome" id="R-MMU-190370" name="FGFR1b ligand binding and activation"/>
            <pathway-xref db="Reactome" id="R-DRE-5674135" name="MAP2K and MAPK activation"/>
            <pathway-xref db="Reactome" id="R-HSA-5689896" name="Ovarian tumor domain proteases"/>
            <pathway-xref db="Reactome" id="R-HSA-2033519" name="Activated point mutants of FGFR2"/>
            <pathway-xref db="Reactome" id="R-SCE-2565942" name="Regulation of PLK1 Activity at G2/M Transition"/>
            <pathway-xref db="Reactome" id="R-RNO-5621480" name="Dectin-2 family"/>
            <pathway-xref db="Reactome" id="R-SPO-5675221" name="Negative regulation of MAPK pathway"/>
            <pathway-xref db="Reactome" id="R-DME-373753" name="Nephrin family interactions"/>
            <pathway-xref db="Reactome" id="R-RNO-1169408" name="ISG15 antiviral mechanism"/>
            <pathway-xref db="Reactome" id="R-HSA-9702998" name="linifanib-resistant FLT3 mutants"/>
            <pathway-xref db="Reactome" id="R-HSA-203615" name="eNOS activation"/>
            <pathway-xref db="Reactome" id="R-HSA-399997" name="Acetylcholine regulates insulin secretion"/>
            <pathway-xref db="Reactome" id="R-HSA-9674401" name="Sunitinib-resistant PDGFR mutants"/>
            <pathway-xref db="Reactome" id="R-CEL-936837" name="Ion transport by P-type ATPases"/>
            <pathway-xref db="Reactome" id="R-DDI-9013404" name="RAC2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-418555" name="G alpha (s) signalling events"/>
            <pathway-xref db="Reactome" id="R-CEL-9634635" name="Estrogen-stimulated signaling through PRKCZ"/>
          </entry>
          <signature-library-release library="PROSITE_PATTERNS" version="2021_01"/>
        </signature>
        <model-ac>PS00107</model-ac>
        <locations>
          <patternscan-location level="STRONG" start="934" end="961">
            <location-fragments>
              <patternscan-location-fragment start="934" end="961" dc-status="CONTINUOUS"/>
            </location-fragments>
            <alignment>LGSGAFGSVYqGiikdfegldttpVAIK</alignment>
          </patternscan-location>
        </locations>
      </patternscan-match>
      <profilescan-match>
        <signature ac="PS50853" desc="Fibronectin type-III domain profile." name="FN3">
          <entry ac="IPR003961" desc="Fibronectin type III" name="FN3_dom" type="DOMAIN">
            <go-xref category="MOLECULAR_FUNCTION" db="GO" id="GO:0005515" name="protein binding"/>
            <pathway-xref db="Reactome" id="R-HSA-74749" name="Signal attenuation"/>
            <pathway-xref db="Reactome" id="R-MMU-1474228" name="Degradation of the extracellular matrix"/>
            <pathway-xref db="Reactome" id="R-HSA-202733" name="Cell surface interactions at the vascular wall"/>
            <pathway-xref db="Reactome" id="R-HSA-5673001" name="RAF/MAP kinase cascade"/>
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            <pathway-xref db="Reactome" id="R-RNO-112411" name="MAPK1 (ERK2) activation"/>
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            <pathway-xref db="MetaCyc" id="PWY-6827" name="gellan degradation"/>
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            <pathway-xref db="Reactome" id="R-RNO-418889" name="Caspase activation via Dependence Receptors in the absence of ligand"/>
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            <pathway-xref db="MetaCyc" id="PWY-7437" name="protein O-[N-acetyl]-glucosylation"/>
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            <pathway-xref db="Reactome" id="R-CFA-6785807" name="Interleukin-4 and Interleukin-13 signaling"/>
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            <pathway-xref db="Reactome" id="R-HSA-9696270" name="RND2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-193648" name="NRAGE signals death through JNK"/>
            <pathway-xref db="Reactome" id="R-HSA-9696264" name="RND3 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-9696273" name="RND1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-110056" name="MAPK3 (ERK1) activation"/>
            <pathway-xref db="Reactome" id="R-MMU-372708" name="p130Cas linkage to MAPK signaling for integrins"/>
            <pathway-xref db="Reactome" id="R-RNO-6785807" name="Interleukin-4 and Interleukin-13 signaling"/>
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            <pathway-xref db="Reactome" id="R-HSA-9013423" name="RAC3 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-9020558" name="Interleukin-2 signaling"/>
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            <pathway-xref db="Reactome" id="R-HSA-212676" name="Dopamine Neurotransmitter Release Cycle"/>
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            <pathway-xref db="Reactome" id="R-MMU-8983432" name="Interleukin-15 signaling"/>
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            <pathway-xref db="MetaCyc" id="PWY-7822" name="chitin degradation III (Serratia)"/>
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            <pathway-xref db="MetaCyc" id="PWY-4702" name="phytate degradation I"/>
            <pathway-xref db="Reactome" id="R-MMU-9013408" name="RHOG GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-6807004" name="Negative regulation of MET activity"/>
            <pathway-xref db="Reactome" id="R-RNO-8849932" name="Synaptic adhesion-like molecules"/>
            <pathway-xref db="Reactome" id="R-CFA-912526" name="Interleukin receptor SHC signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-6788467" name="IL-6-type cytokine receptor ligand interactions"/>
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            <pathway-xref db="Reactome" id="R-HSA-9013408" name="RHOG GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-372708" name="p130Cas linkage to MAPK signaling for integrins"/>
            <pathway-xref db="Reactome" id="R-HSA-381426" name="Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"/>
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            <pathway-xref db="Reactome" id="R-HSA-5689603" name="UCH proteinases"/>
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            <pathway-xref db="Reactome" id="R-RNO-982772" name="Growth hormone receptor signaling"/>
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            <pathway-xref db="Reactome" id="R-HSA-8985947" name="Interleukin-9 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-1059683" name="Interleukin-6 signaling"/>
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            <pathway-xref db="Reactome" id="R-RNO-196108" name="Pregnenolone biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-5689603" name="UCH proteinases"/>
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            <pathway-xref db="Reactome" id="R-DRE-3928665" name="EPH-ephrin mediated repulsion of cells"/>
            <pathway-xref db="Reactome" id="R-MMU-418889" name="Caspase activation via Dependence Receptors in the absence of ligand"/>
            <pathway-xref db="MetaCyc" id="PWY-7246" name="pectin degradation I"/>
            <pathway-xref db="Reactome" id="R-MMU-9020956" name="Interleukin-27 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9020956" name="Interleukin-27 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-5688849" name="Defective CSF2RB causes SMDP5"/>
            <pathway-xref db="MetaCyc" id="PWY-7511" name="protein ubiquitination"/>
            <pathway-xref db="Reactome" id="R-MMU-2428933" name="SHC-related events triggered by IGF1R"/>
            <pathway-xref db="Reactome" id="R-HSA-210500" name="Glutamate Neurotransmitter Release Cycle"/>
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            <pathway-xref db="MetaCyc" id="PWY-6348" name="phosphate acquisition"/>
            <pathway-xref db="Reactome" id="R-RNO-418885" name="DCC mediated attractive signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-428890" name="Role of ABL in ROBO-SLIT signaling"/>
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            <pathway-xref db="Reactome" id="R-MMU-8985947" name="Interleukin-9 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-6788" name="cellulose degradation II (fungi)"/>
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            <pathway-xref db="MetaCyc" id="PWY-6686" name="mannosylglucosylglycerate biosynthesis I"/>
            <pathway-xref db="MetaCyc" id="PWY-8052" name="2-arachidonoylglycerol biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-MMU-1170546" name="Prolactin receptor signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9013406" name="RHOQ GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-1170546" name="Prolactin receptor signaling"/>
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            <pathway-xref db="MetaCyc" id="PWY-6385" name="peptidoglycan biosynthesis III (mycobacteria)"/>
            <pathway-xref db="Reactome" id="R-HSA-982772" name="Growth hormone receptor signaling"/>
            <pathway-xref db="Reactome" id="R-GGA-2682334" name="EPH-Ephrin signaling"/>
            <pathway-xref db="Reactome" id="R-CEL-373756" name="SDK interactions"/>
            <pathway-xref db="Reactome" id="R-RNO-8951664" name="Neddylation"/>
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            <pathway-xref db="Reactome" id="R-MMU-445355" name="Smooth Muscle Contraction"/>
            <pathway-xref db="Reactome" id="R-HSA-2428928" name="IRS-related events triggered by IGF1R"/>
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            <pathway-xref db="Reactome" id="R-RNO-9020558" name="Interleukin-2 signaling"/>
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            <pathway-xref db="MetaCyc" id="PWY-8282" name="adenosylcobinamide-GDP salvage from assorted adenosylcobamides"/>
            <pathway-xref db="Reactome" id="R-MMU-373752" name="Netrin-1 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-354192" name="Integrin signaling"/>
            <pathway-xref db="Reactome" id="R-DME-376176" name="Signaling by ROBO receptors"/>
            <pathway-xref db="Reactome" id="R-MMU-6783783" name="Interleukin-10 signaling"/>
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            <pathway-xref db="Reactome" id="R-HSA-376176" name="Signaling by ROBO receptors"/>
            <pathway-xref db="Reactome" id="R-MMU-3000157" name="Laminin interactions"/>
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            <pathway-xref db="MetaCyc" id="PWY-7771" name="butachlor degradation"/>
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            <pathway-xref db="MetaCyc" id="PWY-6724" name="starch degradation II"/>
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            <pathway-xref db="Reactome" id="R-SSC-9020933" name="Interleukin-23 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-1474244" name="Extracellular matrix organization"/>
            <pathway-xref db="Reactome" id="R-RNO-114608" name="Platelet degranulation"/>
            <pathway-xref db="Reactome" id="R-MMU-216083" name="Integrin cell surface interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-181429" name="Serotonin Neurotransmitter Release Cycle"/>
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            <pathway-xref db="Reactome" id="R-RNO-1266695" name="Interleukin-7 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-204005" name="COPII-mediated vesicle transport"/>
            <pathway-xref db="Reactome" id="R-HSA-8984722" name="Interleukin-35 Signalling"/>
            <pathway-xref db="Reactome" id="R-MMU-210993" name="Tie2 Signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-8984722" name="Interleukin-35 Signalling"/>
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            <pathway-xref db="Reactome" id="R-RNO-6798695" name="Neutrophil degranulation"/>
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            <pathway-xref db="Reactome" id="R-MMU-264642" name="Acetylcholine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-3928662" name="EPHB-mediated forward signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-2586552" name="Signaling by Leptin"/>
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            <pathway-xref db="Reactome" id="R-GGA-8854691" name="Interleukin-20 family signaling"/>
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            <pathway-xref db="Reactome" id="R-HSA-3928662" name="EPHB-mediated forward signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-5632681" name="Ligand-receptor interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-6785807" name="Interleukin-4 and Interleukin-13 signaling"/>
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            <pathway-xref db="Reactome" id="R-HSA-909733" name="Interferon alpha/beta signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-74713" name="IRS activation"/>
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            <pathway-xref db="Reactome" id="R-RNO-373753" name="Nephrin family interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-186797" name="Signaling by PDGF"/>
            <pathway-xref db="Reactome" id="R-RNO-210500" name="Glutamate Neurotransmitter Release Cycle"/>
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            <pathway-xref db="Reactome" id="R-MMU-9013424" name="RHOV GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-3214841" name="PKMTs methylate histone lysines"/>
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            <pathway-xref db="Reactome" id="R-RNO-1170546" name="Prolactin receptor signaling"/>
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            <pathway-xref db="Reactome" id="R-CFA-1266695" name="Interleukin-7 signaling"/>
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            <pathway-xref db="Reactome" id="R-CEL-9013406" name="RHOQ GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-112411" name="MAPK1 (ERK2) activation"/>
            <pathway-xref db="Reactome" id="R-MMU-512988" name="Interleukin-3, Interleukin-5 and GM-CSF signaling"/>
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            <pathway-xref db="Reactome" id="R-HSA-204005" name="COPII-mediated vesicle transport"/>
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            <pathway-xref db="Reactome" id="R-HSA-77387" name="Insulin receptor recycling"/>
            <pathway-xref db="Reactome" id="R-MMU-2428928" name="IRS-related events triggered by IGF1R"/>
            <pathway-xref db="Reactome" id="R-DRE-2682334" name="EPH-Ephrin signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9020933" name="Interleukin-23 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-2404192" name="Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)"/>
            <pathway-xref db="Reactome" id="R-DME-77387" name="Insulin receptor recycling"/>
            <pathway-xref db="Reactome" id="R-DRE-210993" name="Tie2 Signaling"/>
            <pathway-xref db="Reactome" id="R-DME-5632681" name="Ligand-receptor interactions"/>
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            <pathway-xref db="MetaCyc" id="PWY-8119" name="microcin B17 biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-6991" name="(-)-camphor biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-MMU-182971" name="EGFR downregulation"/>
            <pathway-xref db="Reactome" id="R-MMU-375165" name="NCAM signaling for neurite out-growth"/>
            <pathway-xref db="Reactome" id="R-CEL-3928665" name="EPH-ephrin mediated repulsion of cells"/>
            <pathway-xref db="Reactome" id="R-MMU-196108" name="Pregnenolone biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-5687128" name="MAPK6/MAPK4 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-1442490" name="Collagen degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-1650814" name="Collagen biosynthesis and modifying enzymes"/>
            <pathway-xref db="Reactome" id="R-CFA-8985947" name="Interleukin-9 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-8849932" name="Synaptic adhesion-like molecules"/>
            <pathway-xref db="Reactome" id="R-MMU-2404192" name="Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)"/>
            <pathway-xref db="Reactome" id="R-GGA-449836" name="Other interleukin signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-5673001" name="RAF/MAP kinase cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-912526" name="Interleukin receptor SHC signaling"/>
            <pathway-xref db="Reactome" id="R-CEL-9013420" name="RHOU GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-5674135" name="MAP2K and MAPK activation"/>
            <pathway-xref db="Reactome" id="R-RNO-216083" name="Integrin cell surface interactions"/>
            <pathway-xref db="Reactome" id="R-RNO-445144" name="Signal transduction by L1"/>
            <pathway-xref db="Reactome" id="R-MMU-112411" name="MAPK1 (ERK2) activation"/>
            <pathway-xref db="Reactome" id="R-MMU-9705462" name="Inactivation of CSF3 (G-CSF) signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-9696264" name="RND3 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-74751" name="Insulin receptor signalling cascade"/>
            <pathway-xref db="Reactome" id="R-MMU-9696270" name="RND2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-418886" name="Netrin mediated repulsion signals"/>
            <pathway-xref db="Reactome" id="R-HSA-190373" name="FGFR1c ligand binding and activation"/>
            <pathway-xref db="Reactome" id="R-RNO-912526" name="Interleukin receptor SHC signaling"/>
            <pathway-xref db="Reactome" id="R-DRE-5673001" name="RAF/MAP kinase cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-9696273" name="RND1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-1474244" name="Extracellular matrix organization"/>
            <pathway-xref db="MetaCyc" id="PWY-6456" name="serinol biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-2214320" name="Anchoring fibril formation"/>
            <pathway-xref db="Reactome" id="R-RNO-9009391" name="Extra-nuclear estrogen signaling"/>
            <pathway-xref db="Reactome" id="R-CFA-9020958" name="Interleukin-21 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9027276" name="Erythropoietin activates Phosphoinositide-3-kinase (PI3K)"/>
            <pathway-xref db="Reactome" id="R-HSA-5683826" name="Surfactant metabolism"/>
            <pathway-xref db="Reactome" id="R-RNO-388844" name="Receptor-type tyrosine-protein phosphatases"/>
            <pathway-xref db="Reactome" id="R-MMU-982772" name="Growth hormone receptor signaling"/>
            <pathway-xref db="Reactome" id="R-DME-525793" name="Myogenesis"/>
            <pathway-xref db="Reactome" id="R-CEL-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-5173105" name="O-linked glycosylation"/>
            <pathway-xref db="Reactome" id="R-RNO-8984722" name="Interleukin-35 Signalling"/>
            <pathway-xref db="Reactome" id="R-HSA-9031628" name="NGF-stimulated transcription"/>
            <pathway-xref db="Reactome" id="R-MMU-5635838" name="Activation of SMO"/>
            <pathway-xref db="Reactome" id="R-HSA-447043" name="Neurofascin interactions"/>
            <pathway-xref db="Reactome" id="R-MMU-354192" name="Integrin signaling"/>
            <pathway-xref db="Reactome" id="R-CEL-9013149" name="RAC1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DRE-3928662" name="EPHB-mediated forward signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9020558" name="Interleukin-2 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-3928664" name="Ephrin signaling"/>
            <pathway-xref db="Reactome" id="R-CEL-3928663" name="EPHA-mediated growth cone collapse"/>
            <pathway-xref db="Reactome" id="R-HSA-373760" name="L1CAM interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-8951664" name="Neddylation"/>
            <pathway-xref db="Reactome" id="R-MMU-3928663" name="EPHA-mediated growth cone collapse"/>
            <pathway-xref db="Reactome" id="R-RNO-3928662" name="EPHB-mediated forward signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-5694530" name="Cargo concentration in the ER"/>
            <pathway-xref db="Reactome" id="R-HSA-446107" name="Type I hemidesmosome assembly"/>
            <pathway-xref db="Reactome" id="R-HSA-1266695" name="Interleukin-7 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-74713" name="IRS activation"/>
            <pathway-xref db="MetaCyc" id="PWY-6627" name="salinosporamide A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-9027284" name="Erythropoietin activates RAS"/>
            <pathway-xref db="MetaCyc" id="PWY-6720" name="toyocamycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-CEL-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-HSA-449836" name="Other interleukin signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-140834" name="Extrinsic Pathway of Fibrin Clot Formation"/>
            <pathway-xref db="Reactome" id="R-HSA-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-RNO-3000178" name="ECM proteoglycans"/>
            <pathway-xref db="Reactome" id="R-DRE-3928664" name="Ephrin signaling"/>
            <pathway-xref db="Reactome" id="R-CEL-9013424" name="RHOV GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-9013423" name="RAC3 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-381426" name="Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"/>
            <pathway-xref db="Reactome" id="R-DME-5689603" name="UCH proteinases"/>
            <pathway-xref db="Reactome" id="R-HSA-5632681" name="Ligand-receptor interactions"/>
            <pathway-xref db="Reactome" id="R-MMU-9013420" name="RHOU GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-9013149" name="RAC1 GTPase cycle"/>
          </entry>
          <signature-library-release library="PROSITE_PROFILES" version="2021_01"/>
        </signature>
        <model-ac>PS50853</model-ac>
        <locations>
          <profilescan-location score="15.668844" start="111" end="214">
            <location-fragments>
              <profilescan-location-fragment start="111" end="214" dc-status="CONTINUOUS"/>
            </location-fragments>
            <alignment>EPTFPRafVEFNDrlnqkDIFVTFRWNEPKFTNGVIQKYTVQYWFFENQIIHRTVVIiSnFTILQHKVYNLKPDRVYYFEVQAHNKFGAGSYTKFINVStTYEN</alignment>
          </profilescan-location>
        </locations>
      </profilescan-match>
      <profilescan-match>
        <signature ac="PS50853" desc="Fibronectin type-III domain profile." name="FN3">
          <entry ac="IPR003961" desc="Fibronectin type III" name="FN3_dom" type="DOMAIN">
            <go-xref category="MOLECULAR_FUNCTION" db="GO" id="GO:0005515" name="protein binding"/>
            <pathway-xref db="Reactome" id="R-HSA-74749" name="Signal attenuation"/>
            <pathway-xref db="Reactome" id="R-MMU-1474228" name="Degradation of the extracellular matrix"/>
            <pathway-xref db="Reactome" id="R-HSA-202733" name="Cell surface interactions at the vascular wall"/>
            <pathway-xref db="Reactome" id="R-HSA-5673001" name="RAF/MAP kinase cascade"/>
            <pathway-xref db="Reactome" id="R-DME-428542" name="Regulation of commissural axon pathfinding by SLIT and ROBO"/>
            <pathway-xref db="Reactome" id="R-HSA-447038" name="NrCAM interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-1474228" name="Degradation of the extracellular matrix"/>
            <pathway-xref db="Reactome" id="R-CEL-373752" name="Netrin-1 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-2428928" name="IRS-related events triggered by IGF1R"/>
            <pathway-xref db="Reactome" id="R-MMU-877300" name="Interferon gamma signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-525793" name="Myogenesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9649948" name="Signaling downstream of RAS mutants"/>
            <pathway-xref db="Reactome" id="R-MMU-8874081" name="MET activates PTK2 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-6902" name="chitin degradation II (Vibrio)"/>
            <pathway-xref db="Reactome" id="R-MMU-445095" name="Interaction between L1 and Ankyrins"/>
            <pathway-xref db="Reactome" id="R-RNO-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-264642" name="Acetylcholine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-3000157" name="Laminin interactions"/>
            <pathway-xref db="Reactome" id="R-MMU-210500" name="Glutamate Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-76009" name="Platelet Aggregation (Plug Formation)"/>
            <pathway-xref db="Reactome" id="R-MMU-8951664" name="Neddylation"/>
            <pathway-xref db="Reactome" id="R-GGA-3928663" name="EPHA-mediated growth cone collapse"/>
            <pathway-xref db="Reactome" id="R-RNO-181430" name="Norepinephrine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-8854691" name="Interleukin-20 family signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-7881" name="virginiae butanolide type gamma-butyrolactones biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-5673001" name="RAF/MAP kinase cascade"/>
            <pathway-xref db="Reactome" id="R-MMU-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-DME-447043" name="Neurofascin interactions"/>
            <pathway-xref db="Reactome" id="R-RNO-2129379" name="Molecules associated with elastic fibres"/>
            <pathway-xref db="Reactome" id="R-HSA-2682334" name="EPH-Ephrin signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-6368" name="3-phosphoinositide degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-2022090" name="Assembly of collagen fibrils and other multimeric structures"/>
            <pathway-xref db="Reactome" id="R-HSA-373753" name="Nephrin family interactions"/>
            <pathway-xref db="Reactome" id="R-MMU-5683826" name="Surfactant metabolism"/>
            <pathway-xref db="Reactome" id="R-RNO-2428933" name="SHC-related events triggered by IGF1R"/>
            <pathway-xref db="Reactome" id="R-HSA-9020591" name="Interleukin-12 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-6955" name="lincomycin A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-3928665" name="EPH-ephrin mediated repulsion of cells"/>
            <pathway-xref db="MetaCyc" id="PWY-6352" name="3-phosphoinositide biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-74749" name="Signal attenuation"/>
            <pathway-xref db="MetaCyc" id="PWY-7882" name="IM-2 type gamma-butyrolactones biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6990" name="(+)-camphor biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-74749" name="Signal attenuation"/>
            <pathway-xref db="Reactome" id="R-HSA-388844" name="Receptor-type tyrosine-protein phosphatases"/>
            <pathway-xref db="Reactome" id="R-RNO-449836" name="Other interleukin signaling"/>
            <pathway-xref db="Reactome" id="R-SSC-9020591" name="Interleukin-12 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-3928665" name="EPH-ephrin mediated repulsion of cells"/>
            <pathway-xref db="Reactome" id="R-MMU-110056" name="MAPK3 (ERK1) activation"/>
            <pathway-xref db="Reactome" id="R-CEL-114608" name="Platelet degranulation"/>
            <pathway-xref db="Reactome" id="R-HSA-9679191" name="Potential therapeutics for SARS"/>
            <pathway-xref db="MetaCyc" id="PWY-5265" name="peptidoglycan biosynthesis II (staphylococci)"/>
            <pathway-xref db="MetaCyc" id="PWY-8247" name="(Kdo)2-lipid A biosynthesis (P. gingivalis)"/>
            <pathway-xref db="Reactome" id="R-MMU-9020591" name="Interleukin-12 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-2022090" name="Assembly of collagen fibrils and other multimeric structures"/>
            <pathway-xref db="Reactome" id="R-MMU-2682334" name="EPH-Ephrin signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-376176" name="Signaling by ROBO receptors"/>
            <pathway-xref db="Reactome" id="R-HSA-437239" name="Recycling pathway of L1"/>
            <pathway-xref db="Reactome" id="R-MMU-912526" name="Interleukin receptor SHC signaling"/>
            <pathway-xref db="Reactome" id="R-CEL-416482" name="G alpha (12/13) signalling events"/>
            <pathway-xref db="MetaCyc" id="PWY-7018" name="paromomycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-9013149" name="RAC1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-9020956" name="Interleukin-27 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-3000171" name="Non-integrin membrane-ECM interactions"/>
            <pathway-xref db="Reactome" id="R-SSC-9027276" name="Erythropoietin activates Phosphoinositide-3-kinase (PI3K)"/>
            <pathway-xref db="Reactome" id="R-HSA-9027283" name="Erythropoietin activates STAT5"/>
            <pathway-xref db="MetaCyc" id="PWY-7119" name="ceramide and sphingolipid recycling and degradation (yeast)"/>
            <pathway-xref db="Reactome" id="R-CFA-9020558" name="Interleukin-2 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-8983432" name="Interleukin-15 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-446107" name="Type I hemidesmosome assembly"/>
            <pathway-xref db="Reactome" id="R-RNO-3928663" name="EPHA-mediated growth cone collapse"/>
            <pathway-xref db="Reactome" id="R-BTA-140834" name="Extrinsic Pathway of Fibrin Clot Formation"/>
            <pathway-xref db="Reactome" id="R-HSA-3214847" name="HATs acetylate histones"/>
            <pathway-xref db="Reactome" id="R-SSC-9027284" name="Erythropoietin activates RAS"/>
            <pathway-xref db="Reactome" id="R-MMU-212676" name="Dopamine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-3000171" name="Non-integrin membrane-ECM interactions"/>
            <pathway-xref db="Reactome" id="R-MMU-418885" name="DCC mediated attractive signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-2122948" name="Activated NOTCH1 Transmits Signal to the Nucleus"/>
            <pathway-xref db="Reactome" id="R-MMU-1566977" name="Fibronectin matrix formation"/>
            <pathway-xref db="Reactome" id="R-MMU-428890" name="Role of ABL in ROBO-SLIT signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-9013408" name="RHOG GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-446107" name="Type I hemidesmosome assembly"/>
            <pathway-xref db="Reactome" id="R-DME-209209" name="Formation of the activated receptor complex"/>
            <pathway-xref db="Reactome" id="R-HSA-390522" name="Striated Muscle Contraction"/>
            <pathway-xref db="Reactome" id="R-HSA-1566977" name="Fibronectin matrix formation"/>
            <pathway-xref db="Reactome" id="R-RNO-390522" name="Striated Muscle Contraction"/>
            <pathway-xref db="Reactome" id="R-HSA-445355" name="Smooth Muscle Contraction"/>
            <pathway-xref db="Reactome" id="R-HSA-6802948" name="Signaling by high-kinase activity BRAF mutants"/>
            <pathway-xref db="Reactome" id="R-RNO-212676" name="Dopamine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-140834" name="Extrinsic Pathway of Fibrin Clot Formation"/>
            <pathway-xref db="Reactome" id="R-DME-418885" name="DCC mediated attractive signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-912694" name="Regulation of IFNA signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-6788467" name="IL-6-type cytokine receptor ligand interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-9006335" name="Signaling by Erythropoietin"/>
            <pathway-xref db="Reactome" id="R-HSA-375165" name="NCAM signaling for neurite out-growth"/>
            <pathway-xref db="Reactome" id="R-RNO-6811558" name="PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-6855" name="chitin degradation I (archaea)"/>
            <pathway-xref db="MetaCyc" id="PWY-7863" name="roseoflavin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-CEL-428542" name="Regulation of commissural axon pathfinding by SLIT and ROBO"/>
            <pathway-xref db="Reactome" id="R-HSA-6788467" name="IL-6-type cytokine receptor ligand interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-8957275" name="Post-translational protein phosphorylation"/>
            <pathway-xref db="Reactome" id="R-HSA-525793" name="Myogenesis"/>
            <pathway-xref db="Reactome" id="R-BTA-912694" name="Regulation of IFNA signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9706369" name="Negative regulation of FLT3"/>
            <pathway-xref db="Reactome" id="R-MMU-8957275" name="Post-translational protein phosphorylation"/>
            <pathway-xref db="Reactome" id="R-MMU-9706369" name="Negative regulation of FLT3"/>
            <pathway-xref db="Reactome" id="R-HSA-418889" name="Caspase activation via Dependence Receptors in the absence of ligand"/>
            <pathway-xref db="Reactome" id="R-HSA-8854691" name="Interleukin-20 family signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-6575" name="juvenile hormone III biosynthesis I"/>
            <pathway-xref db="Reactome" id="R-MMU-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-DME-373752" name="Netrin-1 signaling"/>
            <pathway-xref db="Reactome" id="R-DME-376172" name="DSCAM interactions"/>
            <pathway-xref db="Reactome" id="R-MMU-74751" name="Insulin receptor signalling cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-3928664" name="Ephrin signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9020958" name="Interleukin-21 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-182971" name="EGFR downregulation"/>
            <pathway-xref db="Reactome" id="R-MMU-210991" name="Basigin interactions"/>
            <pathway-xref db="Reactome" id="R-MMU-416700" name="Other semaphorin interactions"/>
            <pathway-xref db="Reactome" id="R-MMU-3214847" name="HATs acetylate histones"/>
            <pathway-xref db="Reactome" id="R-RNO-112411" name="MAPK1 (ERK2) activation"/>
            <pathway-xref db="Reactome" id="R-HSA-74713" name="IRS activation"/>
            <pathway-xref db="MetaCyc" id="PWY-7321" name="ecdysteroid metabolism (arthropods)"/>
            <pathway-xref db="Reactome" id="R-MMU-3928664" name="Ephrin signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-376172" name="DSCAM interactions"/>
            <pathway-xref db="Reactome" id="R-CEL-418885" name="DCC mediated attractive signaling"/>
            <pathway-xref db="Reactome" id="R-DME-209228" name="Formation of the activated STAT92E dimer and transport to the nucleus"/>
            <pathway-xref db="MetaCyc" id="PWY-6827" name="gellan degradation"/>
            <pathway-xref db="Reactome" id="R-CEL-351906" name="Apoptotic cleavage of cell adhesion proteins"/>
            <pathway-xref db="Reactome" id="R-HSA-8874081" name="MET activates PTK2 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-2892247" name="POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation"/>
            <pathway-xref db="Reactome" id="R-DME-8849932" name="Synaptic adhesion-like molecules"/>
            <pathway-xref db="MetaCyc" id="PWY-7878" name="A-factor gamma-butyrolactone biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-77387" name="Insulin receptor recycling"/>
            <pathway-xref db="Reactome" id="R-HSA-9010553" name="Regulation of expression of SLITs and ROBOs"/>
            <pathway-xref db="Reactome" id="R-MMU-6785807" name="Interleukin-4 and Interleukin-13 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9010642" name="ROBO receptors bind AKAP5"/>
            <pathway-xref db="Reactome" id="R-HSA-181430" name="Norepinephrine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-BTA-909733" name="Interferon alpha/beta signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-MMU-9020933" name="Interleukin-23 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-210991" name="Basigin interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-5694530" name="Cargo concentration in the ER"/>
            <pathway-xref db="Reactome" id="R-RNO-416700" name="Other semaphorin interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-9009391" name="Extra-nuclear estrogen signaling"/>
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            <pathway-xref db="Reactome" id="R-MMU-210993" name="Tie2 Signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-8984722" name="Interleukin-35 Signalling"/>
            <pathway-xref db="Reactome" id="R-HSA-163125" name="Post-translational modification: synthesis of GPI-anchored proteins"/>
            <pathway-xref db="Reactome" id="R-RNO-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-MMU-8856828" name="Clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-CEL-3928664" name="Ephrin signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-416482" name="G alpha (12/13) signalling events"/>
            <pathway-xref db="Reactome" id="R-MMU-264642" name="Acetylcholine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-3928662" name="EPHB-mediated forward signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-2586552" name="Signaling by Leptin"/>
            <pathway-xref db="Reactome" id="R-DME-388844" name="Receptor-type tyrosine-protein phosphatases"/>
            <pathway-xref db="Reactome" id="R-RNO-5173105" name="O-linked glycosylation"/>
            <pathway-xref db="Reactome" id="R-HSA-445144" name="Signal transduction by L1"/>
            <pathway-xref db="Reactome" id="R-GGA-8854691" name="Interleukin-20 family signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-196108" name="Pregnenolone biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-3928662" name="EPHB-mediated forward signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-5632681" name="Ligand-receptor interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-6785807" name="Interleukin-4 and Interleukin-13 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-3000178" name="ECM proteoglycans"/>
            <pathway-xref db="Reactome" id="R-MMU-181430" name="Norepinephrine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-CEL-418889" name="Caspase activation via Dependence Receptors in the absence of ligand"/>
            <pathway-xref db="Reactome" id="R-HSA-909733" name="Interferon alpha/beta signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-74713" name="IRS activation"/>
            <pathway-xref db="Reactome" id="R-RNO-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-2151201" name="Transcriptional activation of mitochondrial biogenesis"/>
            <pathway-xref db="Reactome" id="R-MMU-419037" name="NCAM1 interactions"/>
            <pathway-xref db="Reactome" id="R-RNO-373753" name="Nephrin family interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-186797" name="Signaling by PDGF"/>
            <pathway-xref db="Reactome" id="R-RNO-210500" name="Glutamate Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-9013404" name="RAC2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-CEL-376172" name="DSCAM interactions"/>
            <pathway-xref db="Reactome" id="R-MMU-9010553" name="Regulation of expression of SLITs and ROBOs"/>
            <pathway-xref db="Reactome" id="R-RNO-9027284" name="Erythropoietin activates RAS"/>
            <pathway-xref db="Reactome" id="R-CEL-2682334" name="EPH-Ephrin signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-419037" name="NCAM1 interactions"/>
            <pathway-xref db="Reactome" id="R-MMU-8985586" name="SLIT2:ROBO1 increases RHOA activity"/>
            <pathway-xref db="MetaCyc" id="PWY-6471" name="peptidoglycan biosynthesis IV (Enterococcus faecium)"/>
            <pathway-xref db="Reactome" id="R-MMU-9009391" name="Extra-nuclear estrogen signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-9020958" name="Interleukin-21 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-8948216" name="Collagen chain trimerization"/>
            <pathway-xref db="Reactome" id="R-MMU-9013424" name="RHOV GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-3214841" name="PKMTs methylate histone lysines"/>
            <pathway-xref db="Reactome" id="R-MMU-909733" name="Interferon alpha/beta signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-5687128" name="MAPK6/MAPK4 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-216083" name="Integrin cell surface interactions"/>
            <pathway-xref db="Reactome" id="R-RNO-1170546" name="Prolactin receptor signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-354194" name="GRB2:SOS provides linkage to MAPK signaling for Integrins"/>
            <pathway-xref db="Reactome" id="R-HSA-1059683" name="Interleukin-6 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-6811558" name="PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-354194" name="GRB2:SOS provides linkage to MAPK signaling for Integrins"/>
            <pathway-xref db="Reactome" id="R-CFA-1266695" name="Interleukin-7 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-2682334" name="EPH-Ephrin signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-437239" name="Recycling pathway of L1"/>
            <pathway-xref db="Reactome" id="R-HSA-1433557" name="Signaling by SCF-KIT"/>
            <pathway-xref db="MetaCyc" id="PWY-6148" name="tetrahydromethanopterin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6366" name="D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9656223" name="Signaling by RAF1 mutants"/>
            <pathway-xref db="Reactome" id="R-CEL-9013406" name="RHOQ GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-112411" name="MAPK1 (ERK2) activation"/>
            <pathway-xref db="Reactome" id="R-MMU-512988" name="Interleukin-3, Interleukin-5 and GM-CSF signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-6802955" name="Paradoxical activation of RAF signaling by kinase inactive BRAF"/>
            <pathway-xref db="Reactome" id="R-MMU-447043" name="Neurofascin interactions"/>
            <pathway-xref db="Reactome" id="R-MMU-9674555" name="Signaling by CSF3 (G-CSF)"/>
            <pathway-xref db="Reactome" id="R-MMU-416476" name="G alpha (q) signalling events"/>
            <pathway-xref db="Reactome" id="R-MMU-373760" name="L1CAM interactions"/>
            <pathway-xref db="Reactome" id="R-MMU-912694" name="Regulation of IFNA signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-204005" name="COPII-mediated vesicle transport"/>
            <pathway-xref db="Reactome" id="R-HSA-354192" name="Integrin signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-5627123" name="RHO GTPases activate PAKs"/>
            <pathway-xref db="Reactome" id="R-HSA-77387" name="Insulin receptor recycling"/>
            <pathway-xref db="Reactome" id="R-MMU-2428928" name="IRS-related events triggered by IGF1R"/>
            <pathway-xref db="Reactome" id="R-DRE-2682334" name="EPH-Ephrin signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9020933" name="Interleukin-23 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-2404192" name="Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)"/>
            <pathway-xref db="Reactome" id="R-DME-77387" name="Insulin receptor recycling"/>
            <pathway-xref db="Reactome" id="R-DRE-210993" name="Tie2 Signaling"/>
            <pathway-xref db="Reactome" id="R-DME-5632681" name="Ligand-receptor interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-2129379" name="Molecules associated with elastic fibres"/>
            <pathway-xref db="Reactome" id="R-RNO-1474228" name="Degradation of the extracellular matrix"/>
            <pathway-xref db="MetaCyc" id="PWY-8119" name="microcin B17 biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-877312" name="Regulation of IFNG signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-6991" name="(-)-camphor biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-5654687" name="Downstream signaling of activated FGFR1"/>
            <pathway-xref db="Reactome" id="R-HSA-428543" name="Inactivation of CDC42 and RAC1"/>
            <pathway-xref db="Reactome" id="R-MMU-182971" name="EGFR downregulation"/>
            <pathway-xref db="Reactome" id="R-MMU-375165" name="NCAM signaling for neurite out-growth"/>
            <pathway-xref db="Reactome" id="R-CEL-3928665" name="EPH-ephrin mediated repulsion of cells"/>
            <pathway-xref db="Reactome" id="R-MMU-196108" name="Pregnenolone biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-5687128" name="MAPK6/MAPK4 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-1442490" name="Collagen degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-1650814" name="Collagen biosynthesis and modifying enzymes"/>
            <pathway-xref db="Reactome" id="R-CFA-8985947" name="Interleukin-9 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-8849932" name="Synaptic adhesion-like molecules"/>
            <pathway-xref db="Reactome" id="R-MMU-2404192" name="Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)"/>
            <pathway-xref db="Reactome" id="R-GGA-449836" name="Other interleukin signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-5673001" name="RAF/MAP kinase cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-912526" name="Interleukin receptor SHC signaling"/>
            <pathway-xref db="Reactome" id="R-CEL-9013420" name="RHOU GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-5674135" name="MAP2K and MAPK activation"/>
            <pathway-xref db="Reactome" id="R-RNO-216083" name="Integrin cell surface interactions"/>
            <pathway-xref db="Reactome" id="R-RNO-445144" name="Signal transduction by L1"/>
            <pathway-xref db="Reactome" id="R-MMU-112411" name="MAPK1 (ERK2) activation"/>
            <pathway-xref db="Reactome" id="R-MMU-9705462" name="Inactivation of CSF3 (G-CSF) signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-9696264" name="RND3 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-74751" name="Insulin receptor signalling cascade"/>
            <pathway-xref db="Reactome" id="R-MMU-9696270" name="RND2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-418886" name="Netrin mediated repulsion signals"/>
            <pathway-xref db="Reactome" id="R-HSA-190373" name="FGFR1c ligand binding and activation"/>
            <pathway-xref db="Reactome" id="R-RNO-912526" name="Interleukin receptor SHC signaling"/>
            <pathway-xref db="Reactome" id="R-DRE-5673001" name="RAF/MAP kinase cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-9696273" name="RND1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-1474244" name="Extracellular matrix organization"/>
            <pathway-xref db="MetaCyc" id="PWY-6456" name="serinol biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-2214320" name="Anchoring fibril formation"/>
            <pathway-xref db="Reactome" id="R-RNO-9009391" name="Extra-nuclear estrogen signaling"/>
            <pathway-xref db="Reactome" id="R-CFA-9020958" name="Interleukin-21 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9027276" name="Erythropoietin activates Phosphoinositide-3-kinase (PI3K)"/>
            <pathway-xref db="Reactome" id="R-HSA-5683826" name="Surfactant metabolism"/>
            <pathway-xref db="Reactome" id="R-RNO-388844" name="Receptor-type tyrosine-protein phosphatases"/>
            <pathway-xref db="Reactome" id="R-MMU-982772" name="Growth hormone receptor signaling"/>
            <pathway-xref db="Reactome" id="R-DME-525793" name="Myogenesis"/>
            <pathway-xref db="Reactome" id="R-CEL-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-5173105" name="O-linked glycosylation"/>
            <pathway-xref db="Reactome" id="R-RNO-8984722" name="Interleukin-35 Signalling"/>
            <pathway-xref db="Reactome" id="R-HSA-9031628" name="NGF-stimulated transcription"/>
            <pathway-xref db="Reactome" id="R-MMU-5635838" name="Activation of SMO"/>
            <pathway-xref db="Reactome" id="R-HSA-447043" name="Neurofascin interactions"/>
            <pathway-xref db="Reactome" id="R-MMU-354192" name="Integrin signaling"/>
            <pathway-xref db="Reactome" id="R-CEL-9013149" name="RAC1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DRE-3928662" name="EPHB-mediated forward signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9020558" name="Interleukin-2 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-3928664" name="Ephrin signaling"/>
            <pathway-xref db="Reactome" id="R-CEL-3928663" name="EPHA-mediated growth cone collapse"/>
            <pathway-xref db="Reactome" id="R-HSA-373760" name="L1CAM interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-8951664" name="Neddylation"/>
            <pathway-xref db="Reactome" id="R-MMU-3928663" name="EPHA-mediated growth cone collapse"/>
            <pathway-xref db="Reactome" id="R-RNO-3928662" name="EPHB-mediated forward signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-5694530" name="Cargo concentration in the ER"/>
            <pathway-xref db="Reactome" id="R-HSA-446107" name="Type I hemidesmosome assembly"/>
            <pathway-xref db="Reactome" id="R-HSA-1266695" name="Interleukin-7 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-74713" name="IRS activation"/>
            <pathway-xref db="MetaCyc" id="PWY-6627" name="salinosporamide A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-9027284" name="Erythropoietin activates RAS"/>
            <pathway-xref db="MetaCyc" id="PWY-6720" name="toyocamycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-CEL-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-HSA-449836" name="Other interleukin signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-140834" name="Extrinsic Pathway of Fibrin Clot Formation"/>
            <pathway-xref db="Reactome" id="R-HSA-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-RNO-3000178" name="ECM proteoglycans"/>
            <pathway-xref db="Reactome" id="R-DRE-3928664" name="Ephrin signaling"/>
            <pathway-xref db="Reactome" id="R-CEL-9013424" name="RHOV GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-9013423" name="RAC3 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-381426" name="Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"/>
            <pathway-xref db="Reactome" id="R-DME-5689603" name="UCH proteinases"/>
            <pathway-xref db="Reactome" id="R-HSA-5632681" name="Ligand-receptor interactions"/>
            <pathway-xref db="Reactome" id="R-MMU-9013420" name="RHOU GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-9013149" name="RAC1 GTPase cycle"/>
          </entry>
          <signature-library-release library="PROSITE_PROFILES" version="2021_01"/>
        </signature>
        <model-ac>PS50853</model-ac>
        <locations>
          <profilescan-location score="10.785368" start="730" end="832">
            <location-fragments>
              <profilescan-location-fragment start="730" end="832" dc-status="CONTINUOUS"/>
            </location-fragments>
            <alignment>EPNNLSLNEVGTKSMNISWIPSVNLTIPIEFLILEYKNVAsRKWRWTFANYievNNYKITYYVENLLPKTLYKFRLKLKYTEYRedfiwPSDGEEFIFETLGD</alignment>
          </profilescan-location>
        </locations>
      </profilescan-match>
      <profilescan-match>
        <signature ac="PS50853" desc="Fibronectin type-III domain profile." name="FN3">
          <entry ac="IPR003961" desc="Fibronectin type III" name="FN3_dom" type="DOMAIN">
            <go-xref category="MOLECULAR_FUNCTION" db="GO" id="GO:0005515" name="protein binding"/>
            <pathway-xref db="Reactome" id="R-HSA-74749" name="Signal attenuation"/>
            <pathway-xref db="Reactome" id="R-MMU-1474228" name="Degradation of the extracellular matrix"/>
            <pathway-xref db="Reactome" id="R-HSA-202733" name="Cell surface interactions at the vascular wall"/>
            <pathway-xref db="Reactome" id="R-HSA-5673001" name="RAF/MAP kinase cascade"/>
            <pathway-xref db="Reactome" id="R-DME-428542" name="Regulation of commissural axon pathfinding by SLIT and ROBO"/>
            <pathway-xref db="Reactome" id="R-HSA-447038" name="NrCAM interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-1474228" name="Degradation of the extracellular matrix"/>
            <pathway-xref db="Reactome" id="R-CEL-373752" name="Netrin-1 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-2428928" name="IRS-related events triggered by IGF1R"/>
            <pathway-xref db="Reactome" id="R-MMU-877300" name="Interferon gamma signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-525793" name="Myogenesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9649948" name="Signaling downstream of RAS mutants"/>
            <pathway-xref db="Reactome" id="R-MMU-8874081" name="MET activates PTK2 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-6902" name="chitin degradation II (Vibrio)"/>
            <pathway-xref db="Reactome" id="R-MMU-445095" name="Interaction between L1 and Ankyrins"/>
            <pathway-xref db="Reactome" id="R-RNO-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-264642" name="Acetylcholine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-3000157" name="Laminin interactions"/>
            <pathway-xref db="Reactome" id="R-MMU-210500" name="Glutamate Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-76009" name="Platelet Aggregation (Plug Formation)"/>
            <pathway-xref db="Reactome" id="R-MMU-8951664" name="Neddylation"/>
            <pathway-xref db="Reactome" id="R-GGA-3928663" name="EPHA-mediated growth cone collapse"/>
            <pathway-xref db="Reactome" id="R-RNO-181430" name="Norepinephrine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-8854691" name="Interleukin-20 family signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-7881" name="virginiae butanolide type gamma-butyrolactones biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-5673001" name="RAF/MAP kinase cascade"/>
            <pathway-xref db="Reactome" id="R-MMU-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-DME-447043" name="Neurofascin interactions"/>
            <pathway-xref db="Reactome" id="R-RNO-2129379" name="Molecules associated with elastic fibres"/>
            <pathway-xref db="Reactome" id="R-HSA-2682334" name="EPH-Ephrin signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-6368" name="3-phosphoinositide degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-2022090" name="Assembly of collagen fibrils and other multimeric structures"/>
            <pathway-xref db="Reactome" id="R-HSA-373753" name="Nephrin family interactions"/>
            <pathway-xref db="Reactome" id="R-MMU-5683826" name="Surfactant metabolism"/>
            <pathway-xref db="Reactome" id="R-RNO-2428933" name="SHC-related events triggered by IGF1R"/>
            <pathway-xref db="Reactome" id="R-HSA-9020591" name="Interleukin-12 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-6955" name="lincomycin A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-3928665" name="EPH-ephrin mediated repulsion of cells"/>
            <pathway-xref db="MetaCyc" id="PWY-6352" name="3-phosphoinositide biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-74749" name="Signal attenuation"/>
            <pathway-xref db="MetaCyc" id="PWY-7882" name="IM-2 type gamma-butyrolactones biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6990" name="(+)-camphor biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-74749" name="Signal attenuation"/>
            <pathway-xref db="Reactome" id="R-HSA-388844" name="Receptor-type tyrosine-protein phosphatases"/>
            <pathway-xref db="Reactome" id="R-RNO-449836" name="Other interleukin signaling"/>
            <pathway-xref db="Reactome" id="R-SSC-9020591" name="Interleukin-12 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-3928665" name="EPH-ephrin mediated repulsion of cells"/>
            <pathway-xref db="Reactome" id="R-MMU-110056" name="MAPK3 (ERK1) activation"/>
            <pathway-xref db="Reactome" id="R-CEL-114608" name="Platelet degranulation"/>
            <pathway-xref db="Reactome" id="R-HSA-9679191" name="Potential therapeutics for SARS"/>
            <pathway-xref db="MetaCyc" id="PWY-5265" name="peptidoglycan biosynthesis II (staphylococci)"/>
            <pathway-xref db="MetaCyc" id="PWY-8247" name="(Kdo)2-lipid A biosynthesis (P. gingivalis)"/>
            <pathway-xref db="Reactome" id="R-MMU-9020591" name="Interleukin-12 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-2022090" name="Assembly of collagen fibrils and other multimeric structures"/>
            <pathway-xref db="Reactome" id="R-MMU-2682334" name="EPH-Ephrin signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-376176" name="Signaling by ROBO receptors"/>
            <pathway-xref db="Reactome" id="R-HSA-437239" name="Recycling pathway of L1"/>
            <pathway-xref db="Reactome" id="R-MMU-912526" name="Interleukin receptor SHC signaling"/>
            <pathway-xref db="Reactome" id="R-CEL-416482" name="G alpha (12/13) signalling events"/>
            <pathway-xref db="MetaCyc" id="PWY-7018" name="paromomycin biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-CEL-9013404" name="RAC2 GTPase cycle"/>
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            <pathway-xref db="Reactome" id="R-RNO-1059683" name="Interleukin-6 signaling"/>
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            <pathway-xref db="Reactome" id="R-RNO-196108" name="Pregnenolone biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-HSA-6783783" name="Interleukin-10 signaling"/>
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            <pathway-xref db="Reactome" id="R-MMU-418889" name="Caspase activation via Dependence Receptors in the absence of ligand"/>
            <pathway-xref db="MetaCyc" id="PWY-7246" name="pectin degradation I"/>
            <pathway-xref db="Reactome" id="R-MMU-9020956" name="Interleukin-27 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9020956" name="Interleukin-27 signaling"/>
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            <pathway-xref db="Reactome" id="R-HSA-210500" name="Glutamate Neurotransmitter Release Cycle"/>
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            <pathway-xref db="MetaCyc" id="PWY-6348" name="phosphate acquisition"/>
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            <pathway-xref db="Reactome" id="R-HSA-428890" name="Role of ABL in ROBO-SLIT signaling"/>
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            <pathway-xref db="Reactome" id="R-MMU-8985947" name="Interleukin-9 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-6788" name="cellulose degradation II (fungi)"/>
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            <pathway-xref db="MetaCyc" id="PWY-6686" name="mannosylglucosylglycerate biosynthesis I"/>
            <pathway-xref db="MetaCyc" id="PWY-8052" name="2-arachidonoylglycerol biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-MMU-1170546" name="Prolactin receptor signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9013406" name="RHOQ GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-1170546" name="Prolactin receptor signaling"/>
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            <pathway-xref db="Reactome" id="R-RNO-202427" name="Phosphorylation of CD3 and TCR zeta chains"/>
            <pathway-xref db="MetaCyc" id="PWY-6385" name="peptidoglycan biosynthesis III (mycobacteria)"/>
            <pathway-xref db="Reactome" id="R-HSA-982772" name="Growth hormone receptor signaling"/>
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            <pathway-xref db="Reactome" id="R-HSA-372708" name="p130Cas linkage to MAPK signaling for integrins"/>
            <pathway-xref db="Reactome" id="R-MMU-445355" name="Smooth Muscle Contraction"/>
            <pathway-xref db="Reactome" id="R-HSA-2428928" name="IRS-related events triggered by IGF1R"/>
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            <pathway-xref db="Reactome" id="R-RNO-9020558" name="Interleukin-2 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-140834" name="Extrinsic Pathway of Fibrin Clot Formation"/>
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            <pathway-xref db="Reactome" id="R-CEL-5218920" name="VEGFR2 mediated vascular permeability"/>
            <pathway-xref db="Reactome" id="R-HSA-9034015" name="Signaling by NTRK3 (TRKC)"/>
            <pathway-xref db="MetaCyc" id="PWY-8282" name="adenosylcobinamide-GDP salvage from assorted adenosylcobamides"/>
            <pathway-xref db="Reactome" id="R-MMU-373752" name="Netrin-1 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-354192" name="Integrin signaling"/>
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            <pathway-xref db="Reactome" id="R-MMU-6783783" name="Interleukin-10 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-193648" name="NRAGE signals death through JNK"/>
            <pathway-xref db="Reactome" id="R-HSA-376176" name="Signaling by ROBO receptors"/>
            <pathway-xref db="Reactome" id="R-MMU-3000157" name="Laminin interactions"/>
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            <pathway-xref db="MetaCyc" id="PWY-7771" name="butachlor degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-449836" name="Other interleukin signaling"/>
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            <pathway-xref db="MetaCyc" id="PWY-6724" name="starch degradation II"/>
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            <pathway-xref db="Reactome" id="R-SSC-9020933" name="Interleukin-23 signaling"/>
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            <pathway-xref db="Reactome" id="R-HSA-181429" name="Serotonin Neurotransmitter Release Cycle"/>
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            <pathway-xref db="Reactome" id="R-RNO-1266695" name="Interleukin-7 signaling"/>
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            <pathway-xref db="Reactome" id="R-MMU-210993" name="Tie2 Signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-8984722" name="Interleukin-35 Signalling"/>
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            <pathway-xref db="Reactome" id="R-RNO-6798695" name="Neutrophil degranulation"/>
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            <pathway-xref db="Reactome" id="R-MMU-264642" name="Acetylcholine Neurotransmitter Release Cycle"/>
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            <pathway-xref db="Reactome" id="R-HSA-2586552" name="Signaling by Leptin"/>
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            <pathway-xref db="Reactome" id="R-GGA-8854691" name="Interleukin-20 family signaling"/>
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            <pathway-xref db="Reactome" id="R-RNO-373753" name="Nephrin family interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-186797" name="Signaling by PDGF"/>
            <pathway-xref db="Reactome" id="R-RNO-210500" name="Glutamate Neurotransmitter Release Cycle"/>
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            <pathway-xref db="Reactome" id="R-RNO-9027284" name="Erythropoietin activates RAS"/>
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            <pathway-xref db="Reactome" id="R-HSA-419037" name="NCAM1 interactions"/>
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            <pathway-xref db="MetaCyc" id="PWY-6471" name="peptidoglycan biosynthesis IV (Enterococcus faecium)"/>
            <pathway-xref db="Reactome" id="R-MMU-9009391" name="Extra-nuclear estrogen signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-9020958" name="Interleukin-21 signaling"/>
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            <pathway-xref db="Reactome" id="R-MMU-9013424" name="RHOV GTPase cycle"/>
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            <pathway-xref db="Reactome" id="R-MMU-909733" name="Interferon alpha/beta signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-5687128" name="MAPK6/MAPK4 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-216083" name="Integrin cell surface interactions"/>
            <pathway-xref db="Reactome" id="R-RNO-1170546" name="Prolactin receptor signaling"/>
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            <pathway-xref db="Reactome" id="R-HSA-1059683" name="Interleukin-6 signaling"/>
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            <pathway-xref db="Reactome" id="R-CFA-1266695" name="Interleukin-7 signaling"/>
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            <pathway-xref db="Reactome" id="R-RNO-437239" name="Recycling pathway of L1"/>
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            <pathway-xref db="Reactome" id="R-CEL-9013406" name="RHOQ GTPase cycle"/>
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            <pathway-xref db="Reactome" id="R-MMU-512988" name="Interleukin-3, Interleukin-5 and GM-CSF signaling"/>
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            <pathway-xref db="Reactome" id="R-MMU-447043" name="Neurofascin interactions"/>
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            <pathway-xref db="Reactome" id="R-HSA-204005" name="COPII-mediated vesicle transport"/>
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            <pathway-xref db="Reactome" id="R-HSA-77387" name="Insulin receptor recycling"/>
            <pathway-xref db="Reactome" id="R-MMU-2428928" name="IRS-related events triggered by IGF1R"/>
            <pathway-xref db="Reactome" id="R-DRE-2682334" name="EPH-Ephrin signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9020933" name="Interleukin-23 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-2404192" name="Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)"/>
            <pathway-xref db="Reactome" id="R-DME-77387" name="Insulin receptor recycling"/>
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            <pathway-xref db="Reactome" id="R-DME-5632681" name="Ligand-receptor interactions"/>
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            <pathway-xref db="Reactome" id="R-MMU-196108" name="Pregnenolone biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-MMU-8849932" name="Synaptic adhesion-like molecules"/>
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            <pathway-xref db="Reactome" id="R-CEL-9013420" name="RHOU GTPase cycle"/>
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            <pathway-xref db="Reactome" id="R-RNO-216083" name="Integrin cell surface interactions"/>
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            <pathway-xref db="Reactome" id="R-MMU-112411" name="MAPK1 (ERK2) activation"/>
            <pathway-xref db="Reactome" id="R-MMU-9705462" name="Inactivation of CSF3 (G-CSF) signaling"/>
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            <pathway-xref db="Reactome" id="R-RNO-74751" name="Insulin receptor signalling cascade"/>
            <pathway-xref db="Reactome" id="R-MMU-9696270" name="RND2 GTPase cycle"/>
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            <pathway-xref db="Reactome" id="R-RNO-912526" name="Interleukin receptor SHC signaling"/>
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            <pathway-xref db="Reactome" id="R-HSA-9696273" name="RND1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-1474244" name="Extracellular matrix organization"/>
            <pathway-xref db="MetaCyc" id="PWY-6456" name="serinol biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-CFA-9020958" name="Interleukin-21 signaling"/>
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            <pathway-xref db="Reactome" id="R-HSA-5683826" name="Surfactant metabolism"/>
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            <pathway-xref db="Reactome" id="R-MMU-982772" name="Growth hormone receptor signaling"/>
            <pathway-xref db="Reactome" id="R-DME-525793" name="Myogenesis"/>
            <pathway-xref db="Reactome" id="R-CEL-8980692" name="RHOA GTPase cycle"/>
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            <pathway-xref db="Reactome" id="R-RNO-8984722" name="Interleukin-35 Signalling"/>
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            <pathway-xref db="Reactome" id="R-MMU-354192" name="Integrin signaling"/>
            <pathway-xref db="Reactome" id="R-CEL-9013149" name="RAC1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DRE-3928662" name="EPHB-mediated forward signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9020558" name="Interleukin-2 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-3928664" name="Ephrin signaling"/>
            <pathway-xref db="Reactome" id="R-CEL-3928663" name="EPHA-mediated growth cone collapse"/>
            <pathway-xref db="Reactome" id="R-HSA-373760" name="L1CAM interactions"/>
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            <pathway-xref db="Reactome" id="R-MMU-3928663" name="EPHA-mediated growth cone collapse"/>
            <pathway-xref db="Reactome" id="R-RNO-3928662" name="EPHB-mediated forward signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-5694530" name="Cargo concentration in the ER"/>
            <pathway-xref db="Reactome" id="R-HSA-446107" name="Type I hemidesmosome assembly"/>
            <pathway-xref db="Reactome" id="R-HSA-1266695" name="Interleukin-7 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-74713" name="IRS activation"/>
            <pathway-xref db="MetaCyc" id="PWY-6627" name="salinosporamide A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-9027284" name="Erythropoietin activates RAS"/>
            <pathway-xref db="MetaCyc" id="PWY-6720" name="toyocamycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-CEL-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-HSA-449836" name="Other interleukin signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-140834" name="Extrinsic Pathway of Fibrin Clot Formation"/>
            <pathway-xref db="Reactome" id="R-HSA-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-RNO-3000178" name="ECM proteoglycans"/>
            <pathway-xref db="Reactome" id="R-DRE-3928664" name="Ephrin signaling"/>
            <pathway-xref db="Reactome" id="R-CEL-9013424" name="RHOV GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-9013423" name="RAC3 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-381426" name="Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"/>
            <pathway-xref db="Reactome" id="R-DME-5689603" name="UCH proteinases"/>
            <pathway-xref db="Reactome" id="R-HSA-5632681" name="Ligand-receptor interactions"/>
            <pathway-xref db="Reactome" id="R-MMU-9013420" name="RHOU GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-9013149" name="RAC1 GTPase cycle"/>
          </entry>
          <signature-library-release library="PROSITE_PROFILES" version="2021_01"/>
        </signature>
        <model-ac>PS50853</model-ac>
        <locations>
          <profilescan-location score="9.412629" start="625" end="729">
            <location-fragments>
              <profilescan-location-fragment start="625" end="729" dc-status="CONTINUOUS"/>
            </location-fragments>
            <alignment>APDDVVVQVVMPNLAIIDWMPPKKLGCVAVNYEVKWMQYSNSTQENQNLFrfikayklertTNGKFFAVIPSLVPKQKYEIYVSVYSIIRTDVVTDSVIKTIYIS</alignment>
          </profilescan-location>
        </locations>
      </profilescan-match>
      <profilescan-match>
        <signature ac="PS50011" desc="Protein kinase domain profile." name="PROTEIN_KINASE_DOM">
          <entry ac="IPR000719" desc="Protein kinase domain" name="Prot_kinase_dom" type="DOMAIN">
            <go-xref category="MOLECULAR_FUNCTION" db="GO" id="GO:0005524" name="ATP binding"/>
            <go-xref category="MOLECULAR_FUNCTION" db="GO" id="GO:0004672" name="protein kinase activity"/>
            <go-xref category="BIOLOGICAL_PROCESS" db="GO" id="GO:0006468" name="protein phosphorylation"/>
            <pathway-xref db="Reactome" id="R-HSA-74749" name="Signal attenuation"/>
            <pathway-xref db="Reactome" id="R-MMU-2173791" name="TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)"/>
            <pathway-xref db="Reactome" id="R-DRE-418885" name="DCC mediated attractive signaling"/>
            <pathway-xref db="Reactome" id="R-BTA-389356" name="CD28 co-stimulation"/>
            <pathway-xref db="Reactome" id="R-CEL-6804116" name="TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest"/>
            <pathway-xref db="Reactome" id="R-DME-399954" name="Sema3A PAK dependent Axon repulsion"/>
            <pathway-xref db="Reactome" id="R-HSA-113418" name="Formation of the Early Elongation Complex"/>
            <pathway-xref db="Reactome" id="R-HSA-5673001" name="RAF/MAP kinase cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-2565942" name="Regulation of PLK1 Activity at G2/M Transition"/>
            <pathway-xref db="Reactome" id="R-HSA-187042" name="TRKA activation by NGF"/>
            <pathway-xref db="Reactome" id="R-MMU-5620912" name="Anchoring of the basal body to the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-CEL-171007" name="p38MAPK events"/>
            <pathway-xref db="Reactome" id="R-DRE-372708" name="p130Cas linkage to MAPK signaling for integrins"/>
            <pathway-xref db="Reactome" id="R-MMU-6791226" name="Major pathway of rRNA processing in the nucleolus and cytosol"/>
            <pathway-xref db="Reactome" id="R-HSA-2559586" name="DNA Damage/Telomere Stress Induced Senescence"/>
            <pathway-xref db="Reactome" id="R-RNO-6804757" name="Regulation of TP53 Degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-877300" name="Interferon gamma signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-5693616" name="Presynaptic phase of homologous DNA pairing and strand exchange"/>
            <pathway-xref db="Reactome" id="R-CEL-9018519" name="Estrogen-dependent gene expression"/>
            <pathway-xref db="Reactome" id="R-MMU-2454202" name="Fc epsilon receptor (FCERI) signaling"/>
            <pathway-xref db="Reactome" id="R-DME-68911" name="G2 Phase"/>
            <pathway-xref db="Reactome" id="R-MMU-1502540" name="Signaling by Activin"/>
            <pathway-xref db="Reactome" id="R-DME-209461" name="Ubiquitination and degradation of phosphorylated ARM"/>
            <pathway-xref db="Reactome" id="R-RNO-525793" name="Myogenesis"/>
            <pathway-xref db="Reactome" id="R-SPO-75955" name="RNA Polymerase II Transcription Elongation"/>
            <pathway-xref db="Reactome" id="R-DDI-2514853" name="Condensation of Prometaphase Chromosomes"/>
            <pathway-xref db="Reactome" id="R-RNO-380270" name="Recruitment of mitotic centrosome proteins and complexes"/>
            <pathway-xref db="Reactome" id="R-HSA-9649948" name="Signaling downstream of RAS mutants"/>
            <pathway-xref db="Reactome" id="R-DME-1295596" name="Spry regulation of FGF signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-5693565" name="Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"/>
            <pathway-xref db="Reactome" id="R-CEL-77075" name="RNA Pol II CTD phosphorylation and interaction with CE"/>
            <pathway-xref db="Reactome" id="R-RNO-6794361" name="Neurexins and neuroligins"/>
            <pathway-xref db="Reactome" id="R-DRE-9018519" name="Estrogen-dependent gene expression"/>
            <pathway-xref db="Reactome" id="R-XTR-1169091" name="Activation of NF-kappaB in B cells"/>
            <pathway-xref db="Reactome" id="R-SPO-8856828" name="Clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-CEL-182971" name="EGFR downregulation"/>
            <pathway-xref db="Reactome" id="R-RNO-209543" name="p75NTR recruits signalling complexes"/>
            <pathway-xref db="Reactome" id="R-DDI-1660517" name="Synthesis of PIPs at the late endosome membrane"/>
            <pathway-xref db="Reactome" id="R-HSA-8853336" name="Signaling by plasma membrane FGFR1 fusions"/>
            <pathway-xref db="Reactome" id="R-SSC-8854050" name="FBXL7 down-regulates AURKA during mitotic entry and in early mitosis"/>
            <pathway-xref db="Reactome" id="R-RNO-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-BTA-6804756" name="Regulation of TP53 Activity through Phosphorylation"/>
            <pathway-xref db="Reactome" id="R-HSA-9617324" name="Negative regulation of NMDA receptor-mediated neuronal transmission"/>
            <pathway-xref db="Reactome" id="R-MMU-165181" name="Inhibition of TSC complex formation by PKB"/>
            <pathway-xref db="Reactome" id="R-CFA-1433557" name="Signaling by SCF-KIT"/>
            <pathway-xref db="Reactome" id="R-HSA-389356" name="CD28 co-stimulation"/>
            <pathway-xref db="Reactome" id="R-DDI-2029482" name="Regulation of actin dynamics for phagocytic cup formation"/>
            <pathway-xref db="Reactome" id="R-RNO-5690714" name="CD22 mediated BCR regulation"/>
            <pathway-xref db="Reactome" id="R-HSA-163680" name="AMPK inhibits chREBP transcriptional activation activity"/>
            <pathway-xref db="Reactome" id="R-RNO-1963640" name="GRB2 events in ERBB2 signaling"/>
            <pathway-xref db="Reactome" id="R-CEL-198753" name="ERK/MAPK targets"/>
            <pathway-xref db="Reactome" id="R-RNO-9648025" name="EML4 and NUDC in mitotic spindle formation"/>
            <pathway-xref db="Reactome" id="R-DRE-912526" name="Interleukin receptor SHC signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-5654720" name="PI-3K cascade:FGFR4"/>
            <pathway-xref db="Reactome" id="R-HSA-446353" name="Cell-extracellular matrix interactions"/>
            <pathway-xref db="Reactome" id="R-DME-2995383" name="Initiation of Nuclear Envelope (NE) Reformation"/>
            <pathway-xref db="Reactome" id="R-HSA-8854050" name="FBXL7 down-regulates AURKA during mitotic entry and in early mitosis"/>
            <pathway-xref db="Reactome" id="R-HSA-5578775" name="Ion homeostasis"/>
            <pathway-xref db="Reactome" id="R-DME-1433559" name="Regulation of KIT signaling"/>
            <pathway-xref db="Reactome" id="R-CEL-381676" name="Glucagon-like Peptide-1 (GLP1) regulates insulin secretion"/>
            <pathway-xref db="Reactome" id="R-RNO-2173788" name="Downregulation of TGF-beta receptor signaling"/>
            <pathway-xref db="Reactome" id="R-CEL-69202" name="Cyclin E associated events during G1/S transition"/>
            <pathway-xref db="Reactome" id="R-DRE-69202" name="Cyclin E associated events during G1/S transition"/>
            <pathway-xref db="Reactome" id="R-CEL-68949" name="Orc1 removal from chromatin"/>
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            <pathway-xref db="Reactome" id="R-RNO-170984" name="ARMS-mediated activation"/>
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            <pathway-xref db="Reactome" id="R-MMU-68877" name="Mitotic Prometaphase"/>
            <pathway-xref db="Reactome" id="R-SSC-8849470" name="PTK6 Regulates Cell Cycle"/>
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            <pathway-xref db="Reactome" id="R-CEL-437239" name="Recycling pathway of L1"/>
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            <pathway-xref db="Reactome" id="R-DRE-168638" name="NOD1/2 Signaling Pathway"/>
            <pathway-xref db="Reactome" id="R-HSA-202433" name="Generation of second messenger molecules"/>
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            <pathway-xref db="Reactome" id="R-MMU-2299718" name="Condensation of Prophase Chromosomes"/>
            <pathway-xref db="Reactome" id="R-MMU-3295583" name="TRP channels"/>
            <pathway-xref db="Reactome" id="R-SCE-69656" name="Cyclin A:Cdk2-associated events at S phase entry"/>
            <pathway-xref db="Reactome" id="R-CEL-9614399" name="Regulation of localization of FOXO transcription factors"/>
            <pathway-xref db="Reactome" id="R-MMU-2173796" name="SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription"/>
            <pathway-xref db="Reactome" id="R-RNO-881907" name="Gastrin-CREB signalling pathway via PKC and MAPK"/>
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            <pathway-xref db="Reactome" id="R-GGA-8941858" name="Regulation of RUNX3 expression and activity"/>
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            <pathway-xref db="Reactome" id="R-DME-4419969" name="Depolymerisation of the Nuclear Lamina"/>
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            <pathway-xref db="Reactome" id="R-CEL-5673000" name="RAF activation"/>
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            <pathway-xref db="Reactome" id="R-DME-9634635" name="Estrogen-stimulated signaling through PRKCZ"/>
            <pathway-xref db="Reactome" id="R-DRE-975144" name="IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation"/>
            <pathway-xref db="Reactome" id="R-RNO-6804758" name="Regulation of TP53 Activity through Acetylation"/>
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            <pathway-xref db="Reactome" id="R-DRE-5218921" name="VEGFR2 mediated cell proliferation"/>
            <pathway-xref db="Reactome" id="R-HSA-1257604" name="PIP3 activates AKT signaling"/>
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            <pathway-xref db="Reactome" id="R-HSA-163615" name="PKA activation"/>
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            <pathway-xref db="Reactome" id="R-RNO-170968" name="Frs2-mediated activation"/>
            <pathway-xref db="Reactome" id="R-HSA-8963896" name="HDL assembly"/>
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            <pathway-xref db="Reactome" id="R-SPO-72086" name="mRNA Capping"/>
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            <pathway-xref db="Reactome" id="R-RNO-187577" name="SCF(Skp2)-mediated degradation of p27/p21"/>
            <pathway-xref db="Reactome" id="R-DME-214399" name="Activated IkappaB kinase (IKK) complex, Phospho IRD5:KEY dimer, phosphorylates REL in the PGN:PGRP-LC/LE receptor 'signalling complex'"/>
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            <pathway-xref db="Reactome" id="R-HSA-166208" name="mTORC1-mediated signalling"/>
            <pathway-xref db="Reactome" id="R-MMU-168138" name="Toll Like Receptor 9 (TLR9) Cascade"/>
            <pathway-xref db="Reactome" id="R-CEL-432142" name="Platelet sensitization by LDL"/>
            <pathway-xref db="Reactome" id="R-MMU-6785631" name="ERBB2 Regulates Cell Motility"/>
            <pathway-xref db="Reactome" id="R-SPO-5674135" name="MAP2K and MAPK activation"/>
            <pathway-xref db="Reactome" id="R-CEL-9009391" name="Extra-nuclear estrogen signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-5696395" name="Formation of Incision Complex in GG-NER"/>
            <pathway-xref db="Reactome" id="R-MMU-179409" name="APC-Cdc20 mediated degradation of Nek2A"/>
            <pathway-xref db="Reactome" id="R-MMU-389359" name="CD28 dependent Vav1 pathway"/>
            <pathway-xref db="Reactome" id="R-CEL-450604" name="KSRP (KHSRP) binds and destabilizes mRNA"/>
            <pathway-xref db="Reactome" id="R-RNO-194306" name="Neurophilin interactions with VEGF and VEGFR"/>
            <pathway-xref db="MetaCyc" id="PWY-6955" name="lincomycin A biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-MMU-73762" name="RNA Polymerase I Transcription Initiation"/>
            <pathway-xref db="Reactome" id="R-RNO-68949" name="Orc1 removal from chromatin"/>
            <pathway-xref db="Reactome" id="R-DDI-8876198" name="RAB GEFs exchange GTP for GDP on RABs"/>
            <pathway-xref db="Reactome" id="R-HSA-1307965" name="betaKlotho-mediated ligand binding"/>
            <pathway-xref db="Reactome" id="R-DME-9027284" name="Erythropoietin activates RAS"/>
            <pathway-xref db="Reactome" id="R-DRE-5607764" name="CLEC7A (Dectin-1) signaling"/>
            <pathway-xref db="Reactome" id="R-SSC-5578775" name="Ion homeostasis"/>
            <pathway-xref db="Reactome" id="R-CEL-399955" name="SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion"/>
            <pathway-xref db="Reactome" id="R-MMU-74749" name="Signal attenuation"/>
            <pathway-xref db="Reactome" id="R-DDI-9013424" name="RHOV GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-69017" name="CDK-mediated phosphorylation and removal of Cdc6"/>
            <pathway-xref db="Reactome" id="R-RNO-74749" name="Signal attenuation"/>
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            <pathway-xref db="Reactome" id="R-HSA-69017" name="CDK-mediated phosphorylation and removal of Cdc6"/>
            <pathway-xref db="Reactome" id="R-CEL-6804757" name="Regulation of TP53 Degradation"/>
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            <pathway-xref db="Reactome" id="R-DME-190372" name="FGFR3c ligand binding and activation"/>
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            <pathway-xref db="Reactome" id="R-GGA-5218921" name="VEGFR2 mediated cell proliferation"/>
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            <pathway-xref db="Reactome" id="R-SPO-68962" name="Activation of the pre-replicative complex"/>
            <pathway-xref db="Reactome" id="R-RNO-5218921" name="VEGFR2 mediated cell proliferation"/>
            <pathway-xref db="Reactome" id="R-HSA-432722" name="Golgi Associated Vesicle Biogenesis"/>
            <pathway-xref db="Reactome" id="R-RNO-8985947" name="Interleukin-9 signaling"/>
            <pathway-xref db="Reactome" id="R-DME-69231" name="Cyclin D associated events in G1"/>
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            <pathway-xref db="Reactome" id="R-CEL-2173788" name="Downregulation of TGF-beta receptor signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-8941858" name="Regulation of RUNX3 expression and activity"/>
            <pathway-xref db="Reactome" id="R-DME-111933" name="Calmodulin induced events"/>
            <pathway-xref db="Reactome" id="R-CEL-9648025" name="EML4 and NUDC in mitotic spindle formation"/>
            <pathway-xref db="Reactome" id="R-HSA-9679191" name="Potential therapeutics for SARS"/>
            <pathway-xref db="Reactome" id="R-SSC-3928665" name="EPH-ephrin mediated repulsion of cells"/>
            <pathway-xref db="Reactome" id="R-SPO-168638" name="NOD1/2 Signaling Pathway"/>
            <pathway-xref db="Reactome" id="R-DRE-191650" name="Regulation of gap junction activity"/>
            <pathway-xref db="Reactome" id="R-CEL-450321" name="JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1"/>
            <pathway-xref db="Reactome" id="R-DME-383280" name="Nuclear Receptor transcription pathway"/>
            <pathway-xref db="Reactome" id="R-RNO-9018519" name="Estrogen-dependent gene expression"/>
            <pathway-xref db="Reactome" id="R-RNO-69202" name="Cyclin E associated events during G1/S transition"/>
            <pathway-xref db="Reactome" id="R-MMU-69202" name="Cyclin E associated events during G1/S transition"/>
            <pathway-xref db="Reactome" id="R-RNO-9020933" name="Interleukin-23 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-8851907" name="MET activates PI3K/AKT signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-432040" name="Vasopressin regulates renal water homeostasis via Aquaporins"/>
            <pathway-xref db="Reactome" id="R-DRE-5654706" name="FRS-mediated FGFR3 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-164378" name="PKA activation in glucagon signalling"/>
            <pathway-xref db="Reactome" id="R-MMU-9020591" name="Interleukin-12 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-442729" name="CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde"/>
            <pathway-xref db="Reactome" id="R-DME-180292" name="GAB1 signalosome"/>
            <pathway-xref db="Reactome" id="R-RNO-5654727" name="Negative regulation of FGFR2 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-9013409" name="RHOJ GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-8849470" name="PTK6 Regulates Cell Cycle"/>
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            <pathway-xref db="Reactome" id="R-CEL-5607764" name="CLEC7A (Dectin-1) signaling"/>
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            <pathway-xref db="Reactome" id="R-SCE-112409" name="RAF-independent MAPK1/3 activation"/>
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            <pathway-xref db="Reactome" id="R-MMU-9013405" name="RHOD GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-CEL-212676" name="Dopamine Neurotransmitter Release Cycle"/>
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            <pathway-xref db="Reactome" id="R-RNO-1253288" name="Downregulation of ERBB4 signaling"/>
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            <pathway-xref db="Reactome" id="R-SSC-4420097" name="VEGFA-VEGFR2 Pathway"/>
            <pathway-xref db="Reactome" id="R-CEL-72086" name="mRNA Capping"/>
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            <pathway-xref db="Reactome" id="R-RNO-982772" name="Growth hormone receptor signaling"/>
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            <pathway-xref db="Reactome" id="R-SCE-9013026" name="RHOB GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DRE-418592" name="ADP signalling through P2Y purinoceptor 1"/>
            <pathway-xref db="Reactome" id="R-DME-6804116" name="TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest"/>
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            <pathway-xref db="Reactome" id="R-MMU-380259" name="Loss of Nlp from mitotic centrosomes"/>
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            <pathway-xref db="Reactome" id="R-DRE-190377" name="FGFR2b ligand binding and activation"/>
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            <pathway-xref db="Reactome" id="R-DME-214869" name="Phosphorylated CACT, DL and DIF homodimers dissociate from the TL receptor 'signalling complex'"/>
            <pathway-xref db="Reactome" id="R-MMU-3371571" name="HSF1-dependent transactivation"/>
            <pathway-xref db="Reactome" id="R-DDI-9013418" name="RHOBTB2 GTPase cycle"/>
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            <pathway-xref db="Reactome" id="R-GGA-1257604" name="PIP3 activates AKT signaling"/>
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            <pathway-xref db="MetaCyc" id="PWY-8250" name="Escherichia coli serotype O:9 O antigen biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-DME-9020702" name="Interleukin-1 signaling"/>
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            <pathway-xref db="MetaCyc" id="PWY-6626" name="cytidine-5'-diphosphate-glycerol biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-DRE-156711" name="Polo-like kinase mediated events"/>
            <pathway-xref db="Reactome" id="R-SPO-1632852" name="Macroautophagy"/>
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            <pathway-xref db="Reactome" id="R-HSA-2033515" name="t(4;14) translocations of FGFR3"/>
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            <pathway-xref db="Reactome" id="R-RNO-3000170" name="Syndecan interactions"/>
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            <pathway-xref db="Reactome" id="R-HSA-8980692" name="RHOA GTPase cycle"/>
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            <pathway-xref db="Reactome" id="R-RNO-8934903" name="Receptor Mediated Mitophagy"/>
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            <pathway-xref db="Reactome" id="R-RNO-5628897" name="TP53 Regulates Metabolic Genes"/>
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            <pathway-xref db="Reactome" id="R-HSA-2179392" name="EGFR Transactivation by Gastrin"/>
            <pathway-xref db="Reactome" id="R-HSA-9013026" name="RHOB GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-2559582" name="Senescence-Associated Secretory Phenotype (SASP)"/>
            <pathway-xref db="Reactome" id="R-BTA-5621480" name="Dectin-2 family"/>
            <pathway-xref db="Reactome" id="R-DRE-8934903" name="Receptor Mediated Mitophagy"/>
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            <pathway-xref db="Reactome" id="R-MMU-69473" name="G2/M DNA damage checkpoint"/>
            <pathway-xref db="MetaCyc" id="PWY-7740" name="beta-D-mannosyl phosphomycoketide biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-RNO-209560" name="NF-kB is activated and signals survival"/>
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            <pathway-xref db="Reactome" id="R-GGA-418594" name="G alpha (i) signalling events"/>
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            <pathway-xref db="Reactome" id="R-MMU-525793" name="Myogenesis"/>
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            <pathway-xref db="Reactome" id="R-DRE-190322" name="FGFR4 ligand binding and activation"/>
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            <pathway-xref db="Reactome" id="R-RNO-5578775" name="Ion homeostasis"/>
            <pathway-xref db="Reactome" id="R-HSA-9664323" name="FCGR3A-mediated IL10 synthesis"/>
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            <pathway-xref db="Reactome" id="R-HSA-5635838" name="Activation of SMO"/>
            <pathway-xref db="Reactome" id="R-HSA-9702620" name="quizartinib-resistant FLT3 mutants"/>
            <pathway-xref db="Reactome" id="R-DDI-9013423" name="RAC3 GTPase cycle"/>
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            <pathway-xref db="Reactome" id="R-SPO-6791226" name="Major pathway of rRNA processing in the nucleolus and cytosol"/>
            <pathway-xref db="Reactome" id="R-DDI-73772" name="RNA Polymerase I Promoter Escape"/>
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            <pathway-xref db="Reactome" id="R-DRE-202424" name="Downstream TCR signaling"/>
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            <pathway-xref db="Reactome" id="R-GGA-210990" name="PECAM1 interactions"/>
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            <pathway-xref db="Reactome" id="R-MMU-69563" name="p53-Dependent G1 DNA Damage Response"/>
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            <pathway-xref db="Reactome" id="R-SCE-8948751" name="Regulation of PTEN stability and activity"/>
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            <pathway-xref db="Reactome" id="R-DRE-190372" name="FGFR3c ligand binding and activation"/>
            <pathway-xref db="Reactome" id="R-CEL-8854050" name="FBXL7 down-regulates AURKA during mitotic entry and in early mitosis"/>
            <pathway-xref db="Reactome" id="R-HSA-162658" name="Golgi Cisternae Pericentriolar Stack Reorganization"/>
            <pathway-xref db="Reactome" id="R-RNO-114516" name="Disinhibition of SNARE formation"/>
            <pathway-xref db="Reactome" id="R-DME-112411" name="MAPK1 (ERK2) activation"/>
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            <pathway-xref db="Reactome" id="R-CEL-180024" name="DARPP-32 events"/>
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            <pathway-xref db="Reactome" id="R-DDI-5689880" name="Ub-specific processing proteases"/>
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            <pathway-xref db="Reactome" id="R-DDI-156711" name="Polo-like kinase mediated events"/>
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            <pathway-xref db="Reactome" id="R-DME-5693565" name="Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"/>
            <pathway-xref db="Reactome" id="R-HSA-6794361" name="Neurexins and neuroligins"/>
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            <pathway-xref db="Reactome" id="R-HSA-5625900" name="RHO GTPases activate CIT"/>
            <pathway-xref db="Reactome" id="R-MMU-9013406" name="RHOQ GTPase cycle"/>
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            <pathway-xref db="Reactome" id="R-CEL-2672351" name="Stimuli-sensing channels"/>
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            <pathway-xref db="Reactome" id="R-DME-418594" name="G alpha (i) signalling events"/>
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            <pathway-xref db="Reactome" id="R-MMU-1433559" name="Regulation of KIT signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-2404192" name="Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)"/>
            <pathway-xref db="Reactome" id="R-DDI-69473" name="G2/M DNA damage checkpoint"/>
            <pathway-xref db="Reactome" id="R-HSA-399719" name="Trafficking of AMPA receptors"/>
            <pathway-xref db="Reactome" id="R-DME-2173791" name="TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)"/>
            <pathway-xref db="Reactome" id="R-MMU-177504" name="Retrograde neurotrophin signalling"/>
            <pathway-xref db="Reactome" id="R-DDI-165181" name="Inhibition of TSC complex formation by PKB"/>
            <pathway-xref db="Reactome" id="R-RNO-5673001" name="RAF/MAP kinase cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-879415" name="Advanced glycosylation endproduct receptor signaling"/>
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            <pathway-xref db="Reactome" id="R-CEL-4086398" name="Ca2+ pathway"/>
            <pathway-xref db="Reactome" id="R-RNO-9020958" name="Interleukin-21 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-912526" name="Interleukin receptor SHC signaling"/>
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            <pathway-xref db="Reactome" id="R-DRE-5654720" name="PI-3K cascade:FGFR4"/>
            <pathway-xref db="Reactome" id="R-MMU-416993" name="Trafficking of GluR2-containing AMPA receptors"/>
            <pathway-xref db="Reactome" id="R-DRE-9009391" name="Extra-nuclear estrogen signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-198693" name="AKT phosphorylates targets in the nucleus"/>
            <pathway-xref db="Reactome" id="R-HSA-5603041" name="IRAK4 deficiency (TLR2/4)"/>
            <pathway-xref db="Reactome" id="R-DDI-6804758" name="Regulation of TP53 Activity through Acetylation"/>
            <pathway-xref db="Reactome" id="R-MMU-2029485" name="Role of phospholipids in phagocytosis"/>
            <pathway-xref db="Reactome" id="R-MMU-9020702" name="Interleukin-1 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-381042" name="PERK regulates gene expression"/>
            <pathway-xref db="Reactome" id="R-SCE-9009391" name="Extra-nuclear estrogen signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-5674135" name="MAP2K and MAPK activation"/>
            <pathway-xref db="Reactome" id="R-RNO-73762" name="RNA Polymerase I Transcription Initiation"/>
            <pathway-xref db="Reactome" id="R-DME-8934903" name="Receptor Mediated Mitophagy"/>
            <pathway-xref db="Reactome" id="R-DRE-9013106" name="RHOC GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-1236394" name="Signaling by ERBB4"/>
            <pathway-xref db="Reactome" id="R-HSA-2559580" name="Oxidative Stress Induced Senescence"/>
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            <pathway-xref db="Reactome" id="R-GGA-4420097" name="VEGFA-VEGFR2 Pathway"/>
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            <pathway-xref db="Reactome" id="R-CFA-5673001" name="RAF/MAP kinase cascade"/>
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            <pathway-xref db="Reactome" id="R-SCE-5627123" name="RHO GTPases activate PAKs"/>
            <pathway-xref db="Reactome" id="R-DDI-69601" name="Ubiquitin Mediated Degradation of Phosphorylated Cdc25A"/>
            <pathway-xref db="Reactome" id="R-MMU-6804115" name="TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"/>
            <pathway-xref db="Reactome" id="R-DDI-432040" name="Vasopressin regulates renal water homeostasis via Aquaporins"/>
            <pathway-xref db="Reactome" id="R-MMU-9616222" name="Transcriptional regulation of granulopoiesis"/>
            <pathway-xref db="Reactome" id="R-SSC-5621480" name="Dectin-2 family"/>
            <pathway-xref db="Reactome" id="R-DRE-9020958" name="Interleukin-21 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-9705462" name="Inactivation of CSF3 (G-CSF) signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-1963642" name="PI3K events in ERBB2 signaling"/>
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            <pathway-xref db="Reactome" id="R-MMU-429947" name="Deadenylation of mRNA"/>
            <pathway-xref db="Reactome" id="R-SPO-5625740" name="RHO GTPases activate PKNs"/>
            <pathway-xref db="Reactome" id="R-RNO-74751" name="Insulin receptor signalling cascade"/>
            <pathway-xref db="Reactome" id="R-MMU-9696270" name="RND2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-418886" name="Netrin mediated repulsion signals"/>
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            <pathway-xref db="Reactome" id="R-RNO-912526" name="Interleukin receptor SHC signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-111933" name="Calmodulin induced events"/>
            <pathway-xref db="Reactome" id="R-SSC-8878166" name="Transcriptional regulation by RUNX2"/>
            <pathway-xref db="Reactome" id="R-DRE-5673001" name="RAF/MAP kinase cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-9696273" name="RND1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-CEL-68911" name="G2 Phase"/>
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            <pathway-xref db="Reactome" id="R-RNO-9009391" name="Extra-nuclear estrogen signaling"/>
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            <pathway-xref db="Reactome" id="R-MMU-982772" name="Growth hormone receptor signaling"/>
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            <pathway-xref db="Reactome" id="R-RNO-1502540" name="Signaling by Activin"/>
            <pathway-xref db="Reactome" id="R-DME-3301854" name="Nuclear Pore Complex (NPC) Disassembly"/>
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            <pathway-xref db="Reactome" id="R-MMU-3371378" name="Regulation by c-FLIP"/>
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            <pathway-xref db="Reactome" id="R-SCE-5674135" name="MAP2K and MAPK activation"/>
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            <pathway-xref db="Reactome" id="R-MMU-190370" name="FGFR1b ligand binding and activation"/>
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            <pathway-xref db="Reactome" id="R-RNO-1169408" name="ISG15 antiviral mechanism"/>
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            <pathway-xref db="Reactome" id="R-CEL-9634635" name="Estrogen-stimulated signaling through PRKCZ"/>
          </entry>
          <signature-library-release library="PROSITE_PROFILES" version="2021_01"/>
        </signature>
        <model-ac>PS50011</model-ac>
        <locations>
          <profilescan-location score="34.873539" start="928" end="1198">
            <location-fragments>
              <profilescan-location-fragment start="928" end="1198" dc-status="CONTINUOUS"/>
            </location-fragments>
            <alignment>IIQTKFLGSGAFGSVYQGIIKDfeglDTTPVAIKMLKRQA-SSKEKKEFLKEAKLMSHFRHKNVLRILGICLDTNSPLLILELIEPGDLLNYLRNNGTLqssdscaLRLKDLLAMCEDVARGCCYLERQQFVHKDLACRNCLISVRnhenRIVKIGDFGLARDIYKDHYyrMKGDHPLPVRWMAPESLM-FGIFTSQSDVWAFGVLMWEIMSlGEHPYPG-KNYSEVIEYVREGgKL----PKPLNCPPMLYQLMLHCWK-SVIGRPNFTNCVKnIKTL</alignment>
          </profilescan-location>
        </locations>
      </profilescan-match>
      <rpsblast-match>
        <signature ac="cd00063" desc="FN3" name="FN3">
          <entry ac="IPR003961" desc="Fibronectin type III" name="FN3_dom" type="DOMAIN">
            <go-xref category="MOLECULAR_FUNCTION" db="GO" id="GO:0005515" name="protein binding"/>
            <pathway-xref db="Reactome" id="R-HSA-74749" name="Signal attenuation"/>
            <pathway-xref db="Reactome" id="R-MMU-1474228" name="Degradation of the extracellular matrix"/>
            <pathway-xref db="Reactome" id="R-HSA-202733" name="Cell surface interactions at the vascular wall"/>
            <pathway-xref db="Reactome" id="R-HSA-5673001" name="RAF/MAP kinase cascade"/>
            <pathway-xref db="Reactome" id="R-DME-428542" name="Regulation of commissural axon pathfinding by SLIT and ROBO"/>
            <pathway-xref db="Reactome" id="R-HSA-447038" name="NrCAM interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-1474228" name="Degradation of the extracellular matrix"/>
            <pathway-xref db="Reactome" id="R-CEL-373752" name="Netrin-1 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-2428928" name="IRS-related events triggered by IGF1R"/>
            <pathway-xref db="Reactome" id="R-MMU-877300" name="Interferon gamma signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-525793" name="Myogenesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9649948" name="Signaling downstream of RAS mutants"/>
            <pathway-xref db="Reactome" id="R-MMU-8874081" name="MET activates PTK2 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-6902" name="chitin degradation II (Vibrio)"/>
            <pathway-xref db="Reactome" id="R-MMU-445095" name="Interaction between L1 and Ankyrins"/>
            <pathway-xref db="Reactome" id="R-RNO-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-264642" name="Acetylcholine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-3000157" name="Laminin interactions"/>
            <pathway-xref db="Reactome" id="R-MMU-210500" name="Glutamate Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-76009" name="Platelet Aggregation (Plug Formation)"/>
            <pathway-xref db="Reactome" id="R-MMU-8951664" name="Neddylation"/>
            <pathway-xref db="Reactome" id="R-GGA-3928663" name="EPHA-mediated growth cone collapse"/>
            <pathway-xref db="Reactome" id="R-RNO-181430" name="Norepinephrine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-8854691" name="Interleukin-20 family signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-7881" name="virginiae butanolide type gamma-butyrolactones biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-5673001" name="RAF/MAP kinase cascade"/>
            <pathway-xref db="Reactome" id="R-MMU-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-DME-447043" name="Neurofascin interactions"/>
            <pathway-xref db="Reactome" id="R-RNO-2129379" name="Molecules associated with elastic fibres"/>
            <pathway-xref db="Reactome" id="R-HSA-2682334" name="EPH-Ephrin signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-6368" name="3-phosphoinositide degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-2022090" name="Assembly of collagen fibrils and other multimeric structures"/>
            <pathway-xref db="Reactome" id="R-HSA-373753" name="Nephrin family interactions"/>
            <pathway-xref db="Reactome" id="R-MMU-5683826" name="Surfactant metabolism"/>
            <pathway-xref db="Reactome" id="R-RNO-2428933" name="SHC-related events triggered by IGF1R"/>
            <pathway-xref db="Reactome" id="R-HSA-9020591" name="Interleukin-12 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-6955" name="lincomycin A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-3928665" name="EPH-ephrin mediated repulsion of cells"/>
            <pathway-xref db="MetaCyc" id="PWY-6352" name="3-phosphoinositide biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-74749" name="Signal attenuation"/>
            <pathway-xref db="MetaCyc" id="PWY-7882" name="IM-2 type gamma-butyrolactones biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6990" name="(+)-camphor biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-74749" name="Signal attenuation"/>
            <pathway-xref db="Reactome" id="R-HSA-388844" name="Receptor-type tyrosine-protein phosphatases"/>
            <pathway-xref db="Reactome" id="R-RNO-449836" name="Other interleukin signaling"/>
            <pathway-xref db="Reactome" id="R-SSC-9020591" name="Interleukin-12 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-3928665" name="EPH-ephrin mediated repulsion of cells"/>
            <pathway-xref db="Reactome" id="R-MMU-110056" name="MAPK3 (ERK1) activation"/>
            <pathway-xref db="Reactome" id="R-CEL-114608" name="Platelet degranulation"/>
            <pathway-xref db="Reactome" id="R-HSA-9679191" name="Potential therapeutics for SARS"/>
            <pathway-xref db="MetaCyc" id="PWY-5265" name="peptidoglycan biosynthesis II (staphylococci)"/>
            <pathway-xref db="MetaCyc" id="PWY-8247" name="(Kdo)2-lipid A biosynthesis (P. gingivalis)"/>
            <pathway-xref db="Reactome" id="R-MMU-9020591" name="Interleukin-12 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-2022090" name="Assembly of collagen fibrils and other multimeric structures"/>
            <pathway-xref db="Reactome" id="R-MMU-2682334" name="EPH-Ephrin signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-376176" name="Signaling by ROBO receptors"/>
            <pathway-xref db="Reactome" id="R-HSA-437239" name="Recycling pathway of L1"/>
            <pathway-xref db="Reactome" id="R-MMU-912526" name="Interleukin receptor SHC signaling"/>
            <pathway-xref db="Reactome" id="R-CEL-416482" name="G alpha (12/13) signalling events"/>
            <pathway-xref db="MetaCyc" id="PWY-7018" name="paromomycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-9013149" name="RAC1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-9020956" name="Interleukin-27 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-3000171" name="Non-integrin membrane-ECM interactions"/>
            <pathway-xref db="Reactome" id="R-SSC-9027276" name="Erythropoietin activates Phosphoinositide-3-kinase (PI3K)"/>
            <pathway-xref db="Reactome" id="R-HSA-9027283" name="Erythropoietin activates STAT5"/>
            <pathway-xref db="MetaCyc" id="PWY-7119" name="ceramide and sphingolipid recycling and degradation (yeast)"/>
            <pathway-xref db="Reactome" id="R-CFA-9020558" name="Interleukin-2 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-8983432" name="Interleukin-15 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-446107" name="Type I hemidesmosome assembly"/>
            <pathway-xref db="Reactome" id="R-RNO-3928663" name="EPHA-mediated growth cone collapse"/>
            <pathway-xref db="Reactome" id="R-BTA-140834" name="Extrinsic Pathway of Fibrin Clot Formation"/>
            <pathway-xref db="Reactome" id="R-HSA-3214847" name="HATs acetylate histones"/>
            <pathway-xref db="Reactome" id="R-SSC-9027284" name="Erythropoietin activates RAS"/>
            <pathway-xref db="Reactome" id="R-MMU-212676" name="Dopamine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-3000171" name="Non-integrin membrane-ECM interactions"/>
            <pathway-xref db="Reactome" id="R-MMU-418885" name="DCC mediated attractive signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-2122948" name="Activated NOTCH1 Transmits Signal to the Nucleus"/>
            <pathway-xref db="Reactome" id="R-MMU-1566977" name="Fibronectin matrix formation"/>
            <pathway-xref db="Reactome" id="R-MMU-428890" name="Role of ABL in ROBO-SLIT signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-9013408" name="RHOG GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-446107" name="Type I hemidesmosome assembly"/>
            <pathway-xref db="Reactome" id="R-DME-209209" name="Formation of the activated receptor complex"/>
            <pathway-xref db="Reactome" id="R-HSA-390522" name="Striated Muscle Contraction"/>
            <pathway-xref db="Reactome" id="R-HSA-1566977" name="Fibronectin matrix formation"/>
            <pathway-xref db="Reactome" id="R-RNO-390522" name="Striated Muscle Contraction"/>
            <pathway-xref db="Reactome" id="R-HSA-445355" name="Smooth Muscle Contraction"/>
            <pathway-xref db="Reactome" id="R-HSA-6802948" name="Signaling by high-kinase activity BRAF mutants"/>
            <pathway-xref db="Reactome" id="R-RNO-212676" name="Dopamine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-140834" name="Extrinsic Pathway of Fibrin Clot Formation"/>
            <pathway-xref db="Reactome" id="R-DME-418885" name="DCC mediated attractive signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-912694" name="Regulation of IFNA signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-6788467" name="IL-6-type cytokine receptor ligand interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-9006335" name="Signaling by Erythropoietin"/>
            <pathway-xref db="Reactome" id="R-HSA-375165" name="NCAM signaling for neurite out-growth"/>
            <pathway-xref db="Reactome" id="R-RNO-6811558" name="PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-6855" name="chitin degradation I (archaea)"/>
            <pathway-xref db="MetaCyc" id="PWY-7863" name="roseoflavin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-CEL-428542" name="Regulation of commissural axon pathfinding by SLIT and ROBO"/>
            <pathway-xref db="Reactome" id="R-HSA-6788467" name="IL-6-type cytokine receptor ligand interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-8957275" name="Post-translational protein phosphorylation"/>
            <pathway-xref db="Reactome" id="R-HSA-525793" name="Myogenesis"/>
            <pathway-xref db="Reactome" id="R-BTA-912694" name="Regulation of IFNA signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9706369" name="Negative regulation of FLT3"/>
            <pathway-xref db="Reactome" id="R-MMU-8957275" name="Post-translational protein phosphorylation"/>
            <pathway-xref db="Reactome" id="R-MMU-9706369" name="Negative regulation of FLT3"/>
            <pathway-xref db="Reactome" id="R-HSA-418889" name="Caspase activation via Dependence Receptors in the absence of ligand"/>
            <pathway-xref db="Reactome" id="R-HSA-8854691" name="Interleukin-20 family signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-6575" name="juvenile hormone III biosynthesis I"/>
            <pathway-xref db="Reactome" id="R-MMU-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-DME-373752" name="Netrin-1 signaling"/>
            <pathway-xref db="Reactome" id="R-DME-376172" name="DSCAM interactions"/>
            <pathway-xref db="Reactome" id="R-MMU-74751" name="Insulin receptor signalling cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-3928664" name="Ephrin signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9020958" name="Interleukin-21 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-182971" name="EGFR downregulation"/>
            <pathway-xref db="Reactome" id="R-MMU-210991" name="Basigin interactions"/>
            <pathway-xref db="Reactome" id="R-MMU-416700" name="Other semaphorin interactions"/>
            <pathway-xref db="Reactome" id="R-MMU-3214847" name="HATs acetylate histones"/>
            <pathway-xref db="Reactome" id="R-RNO-112411" name="MAPK1 (ERK2) activation"/>
            <pathway-xref db="Reactome" id="R-HSA-74713" name="IRS activation"/>
            <pathway-xref db="MetaCyc" id="PWY-7321" name="ecdysteroid metabolism (arthropods)"/>
            <pathway-xref db="Reactome" id="R-MMU-3928664" name="Ephrin signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-376172" name="DSCAM interactions"/>
            <pathway-xref db="Reactome" id="R-CEL-418885" name="DCC mediated attractive signaling"/>
            <pathway-xref db="Reactome" id="R-DME-209228" name="Formation of the activated STAT92E dimer and transport to the nucleus"/>
            <pathway-xref db="MetaCyc" id="PWY-6827" name="gellan degradation"/>
            <pathway-xref db="Reactome" id="R-CEL-351906" name="Apoptotic cleavage of cell adhesion proteins"/>
            <pathway-xref db="Reactome" id="R-HSA-8874081" name="MET activates PTK2 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-2892247" name="POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation"/>
            <pathway-xref db="Reactome" id="R-DME-8849932" name="Synaptic adhesion-like molecules"/>
            <pathway-xref db="MetaCyc" id="PWY-7878" name="A-factor gamma-butyrolactone biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-77387" name="Insulin receptor recycling"/>
            <pathway-xref db="Reactome" id="R-HSA-9010553" name="Regulation of expression of SLITs and ROBOs"/>
            <pathway-xref db="Reactome" id="R-MMU-6785807" name="Interleukin-4 and Interleukin-13 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9010642" name="ROBO receptors bind AKAP5"/>
            <pathway-xref db="Reactome" id="R-HSA-181430" name="Norepinephrine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-BTA-909733" name="Interferon alpha/beta signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-MMU-9020933" name="Interleukin-23 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-210991" name="Basigin interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-5694530" name="Cargo concentration in the ER"/>
            <pathway-xref db="Reactome" id="R-RNO-416700" name="Other semaphorin interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-9009391" name="Extra-nuclear estrogen signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-6802946" name="Signaling by moderate kinase activity BRAF mutants"/>
            <pathway-xref db="Reactome" id="R-HSA-416482" name="G alpha (12/13) signalling events"/>
            <pathway-xref db="Reactome" id="R-HSA-418890" name="Role of second messengers in netrin-1 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-210993" name="Tie2 Signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-512988" name="Interleukin-3, Interleukin-5 and GM-CSF signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-264642" name="Acetylcholine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-9013404" name="RAC2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-1566977" name="Fibronectin matrix formation"/>
            <pathway-xref db="Reactome" id="R-CEL-388844" name="Receptor-type tyrosine-protein phosphatases"/>
            <pathway-xref db="Reactome" id="R-HSA-6811558" name="PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9013424" name="RHOV GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-110056" name="MAPK3 (ERK1) activation"/>
            <pathway-xref db="Reactome" id="R-CEL-193648" name="NRAGE signals death through JNK"/>
            <pathway-xref db="MetaCyc" id="PWY-8176" name="geraniol biosynthesis (cytosol)"/>
            <pathway-xref db="Reactome" id="R-MMU-1433557" name="Signaling by SCF-KIT"/>
            <pathway-xref db="Reactome" id="R-HSA-373756" name="SDK interactions"/>
            <pathway-xref db="Reactome" id="R-RNO-202733" name="Cell surface interactions at the vascular wall"/>
            <pathway-xref db="Reactome" id="R-MMU-1059683" name="Interleukin-6 signaling"/>
            <pathway-xref db="Reactome" id="R-DME-418889" name="Caspase activation via Dependence Receptors in the absence of ligand"/>
            <pathway-xref db="Reactome" id="R-MMU-9027276" name="Erythropoietin activates Phosphoinositide-3-kinase (PI3K)"/>
            <pathway-xref db="Reactome" id="R-HSA-447041" name="CHL1 interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-373752" name="Netrin-1 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-416476" name="G alpha (q) signalling events"/>
            <pathway-xref db="Reactome" id="R-MMU-2214320" name="Anchoring fibril formation"/>
            <pathway-xref db="Reactome" id="R-RNO-375165" name="NCAM signaling for neurite out-growth"/>
            <pathway-xref db="Reactome" id="R-RNO-381426" name="Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"/>
            <pathway-xref db="Reactome" id="R-HSA-9027277" name="Erythropoietin activates Phospholipase C gamma (PLCG)"/>
            <pathway-xref db="Reactome" id="R-MMU-5627123" name="RHO GTPases activate PAKs"/>
            <pathway-xref db="Reactome" id="R-MMU-2129379" name="Molecules associated with elastic fibres"/>
            <pathway-xref db="Reactome" id="R-HSA-3214841" name="PKMTs methylate histone lysines"/>
            <pathway-xref db="Reactome" id="R-HSA-8948216" name="Collagen chain trimerization"/>
            <pathway-xref db="Reactome" id="R-DME-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-6470" name="peptidoglycan biosynthesis V (beta-lactam resistance)"/>
            <pathway-xref db="Reactome" id="R-HSA-8985586" name="SLIT2:ROBO1 increases RHOA activity"/>
            <pathway-xref db="Reactome" id="R-CFA-8983432" name="Interleukin-15 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-7531" name="mannojirimycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-181429" name="Serotonin Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-9674555" name="Signaling by CSF3 (G-CSF)"/>
            <pathway-xref db="Reactome" id="R-MMU-5654687" name="Downstream signaling of activated FGFR1"/>
            <pathway-xref db="Reactome" id="R-MMU-416482" name="G alpha (12/13) signalling events"/>
            <pathway-xref db="Reactome" id="R-HSA-2404192" name="Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)"/>
            <pathway-xref db="Reactome" id="R-MMU-373756" name="SDK interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-1650814" name="Collagen biosynthesis and modifying enzymes"/>
            <pathway-xref db="Reactome" id="R-RNO-77387" name="Insulin receptor recycling"/>
            <pathway-xref db="Reactome" id="R-RNO-3000170" name="Syndecan interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-2979096" name="NOTCH2 Activation and Transmission of Signal to the Nucleus"/>
            <pathway-xref db="Reactome" id="R-RNO-5654687" name="Downstream signaling of activated FGFR1"/>
            <pathway-xref db="Reactome" id="R-RNO-74752" name="Signaling by Insulin receptor"/>
            <pathway-xref db="Reactome" id="R-MMU-114608" name="Platelet degranulation"/>
            <pathway-xref db="Reactome" id="R-RNO-376172" name="DSCAM interactions"/>
            <pathway-xref db="Reactome" id="R-MMU-437239" name="Recycling pathway of L1"/>
            <pathway-xref db="Reactome" id="R-HSA-114608" name="Platelet degranulation"/>
            <pathway-xref db="Reactome" id="R-HSA-428540" name="Activation of RAC1"/>
            <pathway-xref db="Reactome" id="R-DME-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-HSA-9616222" name="Transcriptional regulation of granulopoiesis"/>
            <pathway-xref db="Reactome" id="R-HSA-418885" name="DCC mediated attractive signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-74751" name="Insulin receptor signalling cascade"/>
            <pathway-xref db="Reactome" id="R-MMU-1266695" name="Interleukin-7 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-6365" name="D-myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9705462" name="Inactivation of CSF3 (G-CSF) signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-210991" name="Basigin interactions"/>
            <pathway-xref db="Reactome" id="R-MMU-445144" name="Signal transduction by L1"/>
            <pathway-xref db="Reactome" id="R-CEL-77387" name="Insulin receptor recycling"/>
            <pathway-xref db="Reactome" id="R-DME-9009391" name="Extra-nuclear estrogen signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-8849932" name="Synaptic adhesion-like molecules"/>
            <pathway-xref db="Reactome" id="R-RNO-445095" name="Interaction between L1 and Ankyrins"/>
            <pathway-xref db="Reactome" id="R-HSA-1442490" name="Collagen degradation"/>
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            <pathway-xref db="Reactome" id="R-HSA-9020956" name="Interleukin-27 signaling"/>
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            <pathway-xref db="MetaCyc" id="PWY-6686" name="mannosylglucosylglycerate biosynthesis I"/>
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            <pathway-xref db="Reactome" id="R-MMU-1170546" name="Prolactin receptor signaling"/>
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            <pathway-xref db="Reactome" id="R-HSA-1170546" name="Prolactin receptor signaling"/>
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            <pathway-xref db="Reactome" id="R-MMU-445355" name="Smooth Muscle Contraction"/>
            <pathway-xref db="Reactome" id="R-HSA-2428928" name="IRS-related events triggered by IGF1R"/>
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            <pathway-xref db="MetaCyc" id="PWY-8282" name="adenosylcobinamide-GDP salvage from assorted adenosylcobamides"/>
            <pathway-xref db="Reactome" id="R-MMU-373752" name="Netrin-1 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-354192" name="Integrin signaling"/>
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            <pathway-xref db="Reactome" id="R-MMU-6783783" name="Interleukin-10 signaling"/>
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            <pathway-xref db="Reactome" id="R-MMU-3000157" name="Laminin interactions"/>
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            <pathway-xref db="MetaCyc" id="PWY-6724" name="starch degradation II"/>
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            <pathway-xref db="Reactome" id="R-RNO-1266695" name="Interleukin-7 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-204005" name="COPII-mediated vesicle transport"/>
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            <pathway-xref db="Reactome" id="R-MMU-210993" name="Tie2 Signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-8984722" name="Interleukin-35 Signalling"/>
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            <pathway-xref db="Reactome" id="R-RNO-6798695" name="Neutrophil degranulation"/>
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            <pathway-xref db="Reactome" id="R-MMU-264642" name="Acetylcholine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-3928662" name="EPHB-mediated forward signaling"/>
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            <pathway-xref db="Reactome" id="R-GGA-8854691" name="Interleukin-20 family signaling"/>
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            <pathway-xref db="Reactome" id="R-RNO-210500" name="Glutamate Neurotransmitter Release Cycle"/>
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            <pathway-xref db="MetaCyc" id="PWY-6471" name="peptidoglycan biosynthesis IV (Enterococcus faecium)"/>
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            <pathway-xref db="Reactome" id="R-MMU-9013424" name="RHOV GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-3214841" name="PKMTs methylate histone lysines"/>
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            <pathway-xref db="Reactome" id="R-HSA-354194" name="GRB2:SOS provides linkage to MAPK signaling for Integrins"/>
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            <pathway-xref db="Reactome" id="R-CEL-9013406" name="RHOQ GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-112411" name="MAPK1 (ERK2) activation"/>
            <pathway-xref db="Reactome" id="R-MMU-512988" name="Interleukin-3, Interleukin-5 and GM-CSF signaling"/>
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            <pathway-xref db="Reactome" id="R-MMU-447043" name="Neurofascin interactions"/>
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            <pathway-xref db="Reactome" id="R-HSA-77387" name="Insulin receptor recycling"/>
            <pathway-xref db="Reactome" id="R-MMU-2428928" name="IRS-related events triggered by IGF1R"/>
            <pathway-xref db="Reactome" id="R-DRE-2682334" name="EPH-Ephrin signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9020933" name="Interleukin-23 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-2404192" name="Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)"/>
            <pathway-xref db="Reactome" id="R-DME-77387" name="Insulin receptor recycling"/>
            <pathway-xref db="Reactome" id="R-DRE-210993" name="Tie2 Signaling"/>
            <pathway-xref db="Reactome" id="R-DME-5632681" name="Ligand-receptor interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-2129379" name="Molecules associated with elastic fibres"/>
            <pathway-xref db="Reactome" id="R-RNO-1474228" name="Degradation of the extracellular matrix"/>
            <pathway-xref db="MetaCyc" id="PWY-8119" name="microcin B17 biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-877312" name="Regulation of IFNG signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-6991" name="(-)-camphor biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-5654687" name="Downstream signaling of activated FGFR1"/>
            <pathway-xref db="Reactome" id="R-HSA-428543" name="Inactivation of CDC42 and RAC1"/>
            <pathway-xref db="Reactome" id="R-MMU-182971" name="EGFR downregulation"/>
            <pathway-xref db="Reactome" id="R-MMU-375165" name="NCAM signaling for neurite out-growth"/>
            <pathway-xref db="Reactome" id="R-CEL-3928665" name="EPH-ephrin mediated repulsion of cells"/>
            <pathway-xref db="Reactome" id="R-MMU-196108" name="Pregnenolone biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-5687128" name="MAPK6/MAPK4 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-1442490" name="Collagen degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-1650814" name="Collagen biosynthesis and modifying enzymes"/>
            <pathway-xref db="Reactome" id="R-CFA-8985947" name="Interleukin-9 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-8849932" name="Synaptic adhesion-like molecules"/>
            <pathway-xref db="Reactome" id="R-MMU-2404192" name="Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)"/>
            <pathway-xref db="Reactome" id="R-GGA-449836" name="Other interleukin signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-5673001" name="RAF/MAP kinase cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-912526" name="Interleukin receptor SHC signaling"/>
            <pathway-xref db="Reactome" id="R-CEL-9013420" name="RHOU GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-5674135" name="MAP2K and MAPK activation"/>
            <pathway-xref db="Reactome" id="R-RNO-216083" name="Integrin cell surface interactions"/>
            <pathway-xref db="Reactome" id="R-RNO-445144" name="Signal transduction by L1"/>
            <pathway-xref db="Reactome" id="R-MMU-112411" name="MAPK1 (ERK2) activation"/>
            <pathway-xref db="Reactome" id="R-MMU-9705462" name="Inactivation of CSF3 (G-CSF) signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-9696264" name="RND3 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-74751" name="Insulin receptor signalling cascade"/>
            <pathway-xref db="Reactome" id="R-MMU-9696270" name="RND2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-418886" name="Netrin mediated repulsion signals"/>
            <pathway-xref db="Reactome" id="R-HSA-190373" name="FGFR1c ligand binding and activation"/>
            <pathway-xref db="Reactome" id="R-RNO-912526" name="Interleukin receptor SHC signaling"/>
            <pathway-xref db="Reactome" id="R-DRE-5673001" name="RAF/MAP kinase cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-9696273" name="RND1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-1474244" name="Extracellular matrix organization"/>
            <pathway-xref db="MetaCyc" id="PWY-6456" name="serinol biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-2214320" name="Anchoring fibril formation"/>
            <pathway-xref db="Reactome" id="R-RNO-9009391" name="Extra-nuclear estrogen signaling"/>
            <pathway-xref db="Reactome" id="R-CFA-9020958" name="Interleukin-21 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9027276" name="Erythropoietin activates Phosphoinositide-3-kinase (PI3K)"/>
            <pathway-xref db="Reactome" id="R-HSA-5683826" name="Surfactant metabolism"/>
            <pathway-xref db="Reactome" id="R-RNO-388844" name="Receptor-type tyrosine-protein phosphatases"/>
            <pathway-xref db="Reactome" id="R-MMU-982772" name="Growth hormone receptor signaling"/>
            <pathway-xref db="Reactome" id="R-DME-525793" name="Myogenesis"/>
            <pathway-xref db="Reactome" id="R-CEL-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-5173105" name="O-linked glycosylation"/>
            <pathway-xref db="Reactome" id="R-RNO-8984722" name="Interleukin-35 Signalling"/>
            <pathway-xref db="Reactome" id="R-HSA-9031628" name="NGF-stimulated transcription"/>
            <pathway-xref db="Reactome" id="R-MMU-5635838" name="Activation of SMO"/>
            <pathway-xref db="Reactome" id="R-HSA-447043" name="Neurofascin interactions"/>
            <pathway-xref db="Reactome" id="R-MMU-354192" name="Integrin signaling"/>
            <pathway-xref db="Reactome" id="R-CEL-9013149" name="RAC1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DRE-3928662" name="EPHB-mediated forward signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9020558" name="Interleukin-2 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-3928664" name="Ephrin signaling"/>
            <pathway-xref db="Reactome" id="R-CEL-3928663" name="EPHA-mediated growth cone collapse"/>
            <pathway-xref db="Reactome" id="R-HSA-373760" name="L1CAM interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-8951664" name="Neddylation"/>
            <pathway-xref db="Reactome" id="R-MMU-3928663" name="EPHA-mediated growth cone collapse"/>
            <pathway-xref db="Reactome" id="R-RNO-3928662" name="EPHB-mediated forward signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-5694530" name="Cargo concentration in the ER"/>
            <pathway-xref db="Reactome" id="R-HSA-446107" name="Type I hemidesmosome assembly"/>
            <pathway-xref db="Reactome" id="R-HSA-1266695" name="Interleukin-7 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-74713" name="IRS activation"/>
            <pathway-xref db="MetaCyc" id="PWY-6627" name="salinosporamide A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-9027284" name="Erythropoietin activates RAS"/>
            <pathway-xref db="MetaCyc" id="PWY-6720" name="toyocamycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-CEL-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-HSA-449836" name="Other interleukin signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-140834" name="Extrinsic Pathway of Fibrin Clot Formation"/>
            <pathway-xref db="Reactome" id="R-HSA-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-RNO-3000178" name="ECM proteoglycans"/>
            <pathway-xref db="Reactome" id="R-DRE-3928664" name="Ephrin signaling"/>
            <pathway-xref db="Reactome" id="R-CEL-9013424" name="RHOV GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-9013423" name="RAC3 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-381426" name="Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"/>
            <pathway-xref db="Reactome" id="R-DME-5689603" name="UCH proteinases"/>
            <pathway-xref db="Reactome" id="R-HSA-5632681" name="Ligand-receptor interactions"/>
            <pathway-xref db="Reactome" id="R-MMU-9013420" name="RHOU GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-9013149" name="RAC1 GTPase cycle"/>
          </entry>
          <signature-library-release library="CDD" version="3.18"/>
        </signature>
        <model-ac>cd00063</model-ac>
        <locations>
          <rpsblast-location evalue="3.21646E-4" score="39.0167" start="625" end="725">
            <location-fragments>
              <rpsblast-location-fragment start="625" end="725" dc-status="CONTINUOUS"/>
            </location-fragments>
            <sites>
              <rpsblast-site description="Cytokine receptor motif" numLocations="4">
                <site-locations>
                  <site-location residue="T" start="715" end="715"/>
                  <site-location residue="V" start="718" end="718"/>
                  <site-location residue="V" start="717" end="717"/>
                  <site-location residue="R" start="714" end="714"/>
                </site-locations>
              </rpsblast-site>
            </sites>
          </rpsblast-location>
        </locations>
      </rpsblast-match>
      <rpsblast-match>
        <signature ac="cd00063" desc="FN3" name="FN3">
          <entry ac="IPR003961" desc="Fibronectin type III" name="FN3_dom" type="DOMAIN">
            <go-xref category="MOLECULAR_FUNCTION" db="GO" id="GO:0005515" name="protein binding"/>
            <pathway-xref db="Reactome" id="R-HSA-74749" name="Signal attenuation"/>
            <pathway-xref db="Reactome" id="R-MMU-1474228" name="Degradation of the extracellular matrix"/>
            <pathway-xref db="Reactome" id="R-HSA-202733" name="Cell surface interactions at the vascular wall"/>
            <pathway-xref db="Reactome" id="R-HSA-5673001" name="RAF/MAP kinase cascade"/>
            <pathway-xref db="Reactome" id="R-DME-428542" name="Regulation of commissural axon pathfinding by SLIT and ROBO"/>
            <pathway-xref db="Reactome" id="R-HSA-447038" name="NrCAM interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-1474228" name="Degradation of the extracellular matrix"/>
            <pathway-xref db="Reactome" id="R-CEL-373752" name="Netrin-1 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-2428928" name="IRS-related events triggered by IGF1R"/>
            <pathway-xref db="Reactome" id="R-MMU-877300" name="Interferon gamma signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-525793" name="Myogenesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9649948" name="Signaling downstream of RAS mutants"/>
            <pathway-xref db="Reactome" id="R-MMU-8874081" name="MET activates PTK2 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-6902" name="chitin degradation II (Vibrio)"/>
            <pathway-xref db="Reactome" id="R-MMU-445095" name="Interaction between L1 and Ankyrins"/>
            <pathway-xref db="Reactome" id="R-RNO-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-264642" name="Acetylcholine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-3000157" name="Laminin interactions"/>
            <pathway-xref db="Reactome" id="R-MMU-210500" name="Glutamate Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-76009" name="Platelet Aggregation (Plug Formation)"/>
            <pathway-xref db="Reactome" id="R-MMU-8951664" name="Neddylation"/>
            <pathway-xref db="Reactome" id="R-GGA-3928663" name="EPHA-mediated growth cone collapse"/>
            <pathway-xref db="Reactome" id="R-RNO-181430" name="Norepinephrine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-8854691" name="Interleukin-20 family signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-7881" name="virginiae butanolide type gamma-butyrolactones biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-5673001" name="RAF/MAP kinase cascade"/>
            <pathway-xref db="Reactome" id="R-MMU-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-DME-447043" name="Neurofascin interactions"/>
            <pathway-xref db="Reactome" id="R-RNO-2129379" name="Molecules associated with elastic fibres"/>
            <pathway-xref db="Reactome" id="R-HSA-2682334" name="EPH-Ephrin signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-6368" name="3-phosphoinositide degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-2022090" name="Assembly of collagen fibrils and other multimeric structures"/>
            <pathway-xref db="Reactome" id="R-HSA-373753" name="Nephrin family interactions"/>
            <pathway-xref db="Reactome" id="R-MMU-5683826" name="Surfactant metabolism"/>
            <pathway-xref db="Reactome" id="R-RNO-2428933" name="SHC-related events triggered by IGF1R"/>
            <pathway-xref db="Reactome" id="R-HSA-9020591" name="Interleukin-12 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-6955" name="lincomycin A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-3928665" name="EPH-ephrin mediated repulsion of cells"/>
            <pathway-xref db="MetaCyc" id="PWY-6352" name="3-phosphoinositide biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-74749" name="Signal attenuation"/>
            <pathway-xref db="MetaCyc" id="PWY-7882" name="IM-2 type gamma-butyrolactones biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6990" name="(+)-camphor biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-74749" name="Signal attenuation"/>
            <pathway-xref db="Reactome" id="R-HSA-388844" name="Receptor-type tyrosine-protein phosphatases"/>
            <pathway-xref db="Reactome" id="R-RNO-449836" name="Other interleukin signaling"/>
            <pathway-xref db="Reactome" id="R-SSC-9020591" name="Interleukin-12 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-3928665" name="EPH-ephrin mediated repulsion of cells"/>
            <pathway-xref db="Reactome" id="R-MMU-110056" name="MAPK3 (ERK1) activation"/>
            <pathway-xref db="Reactome" id="R-CEL-114608" name="Platelet degranulation"/>
            <pathway-xref db="Reactome" id="R-HSA-9679191" name="Potential therapeutics for SARS"/>
            <pathway-xref db="MetaCyc" id="PWY-5265" name="peptidoglycan biosynthesis II (staphylococci)"/>
            <pathway-xref db="MetaCyc" id="PWY-8247" name="(Kdo)2-lipid A biosynthesis (P. gingivalis)"/>
            <pathway-xref db="Reactome" id="R-MMU-9020591" name="Interleukin-12 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-2022090" name="Assembly of collagen fibrils and other multimeric structures"/>
            <pathway-xref db="Reactome" id="R-MMU-2682334" name="EPH-Ephrin signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-376176" name="Signaling by ROBO receptors"/>
            <pathway-xref db="Reactome" id="R-HSA-437239" name="Recycling pathway of L1"/>
            <pathway-xref db="Reactome" id="R-MMU-912526" name="Interleukin receptor SHC signaling"/>
            <pathway-xref db="Reactome" id="R-CEL-416482" name="G alpha (12/13) signalling events"/>
            <pathway-xref db="MetaCyc" id="PWY-7018" name="paromomycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-9013149" name="RAC1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-9020956" name="Interleukin-27 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-3000171" name="Non-integrin membrane-ECM interactions"/>
            <pathway-xref db="Reactome" id="R-SSC-9027276" name="Erythropoietin activates Phosphoinositide-3-kinase (PI3K)"/>
            <pathway-xref db="Reactome" id="R-HSA-9027283" name="Erythropoietin activates STAT5"/>
            <pathway-xref db="MetaCyc" id="PWY-7119" name="ceramide and sphingolipid recycling and degradation (yeast)"/>
            <pathway-xref db="Reactome" id="R-CFA-9020558" name="Interleukin-2 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-8983432" name="Interleukin-15 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-446107" name="Type I hemidesmosome assembly"/>
            <pathway-xref db="Reactome" id="R-RNO-3928663" name="EPHA-mediated growth cone collapse"/>
            <pathway-xref db="Reactome" id="R-BTA-140834" name="Extrinsic Pathway of Fibrin Clot Formation"/>
            <pathway-xref db="Reactome" id="R-HSA-3214847" name="HATs acetylate histones"/>
            <pathway-xref db="Reactome" id="R-SSC-9027284" name="Erythropoietin activates RAS"/>
            <pathway-xref db="Reactome" id="R-MMU-212676" name="Dopamine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-3000171" name="Non-integrin membrane-ECM interactions"/>
            <pathway-xref db="Reactome" id="R-MMU-418885" name="DCC mediated attractive signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-2122948" name="Activated NOTCH1 Transmits Signal to the Nucleus"/>
            <pathway-xref db="Reactome" id="R-MMU-1566977" name="Fibronectin matrix formation"/>
            <pathway-xref db="Reactome" id="R-MMU-428890" name="Role of ABL in ROBO-SLIT signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-9013408" name="RHOG GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-446107" name="Type I hemidesmosome assembly"/>
            <pathway-xref db="Reactome" id="R-DME-209209" name="Formation of the activated receptor complex"/>
            <pathway-xref db="Reactome" id="R-HSA-390522" name="Striated Muscle Contraction"/>
            <pathway-xref db="Reactome" id="R-HSA-1566977" name="Fibronectin matrix formation"/>
            <pathway-xref db="Reactome" id="R-RNO-390522" name="Striated Muscle Contraction"/>
            <pathway-xref db="Reactome" id="R-HSA-445355" name="Smooth Muscle Contraction"/>
            <pathway-xref db="Reactome" id="R-HSA-6802948" name="Signaling by high-kinase activity BRAF mutants"/>
            <pathway-xref db="Reactome" id="R-RNO-212676" name="Dopamine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-140834" name="Extrinsic Pathway of Fibrin Clot Formation"/>
            <pathway-xref db="Reactome" id="R-DME-418885" name="DCC mediated attractive signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-912694" name="Regulation of IFNA signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-6788467" name="IL-6-type cytokine receptor ligand interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-9006335" name="Signaling by Erythropoietin"/>
            <pathway-xref db="Reactome" id="R-HSA-375165" name="NCAM signaling for neurite out-growth"/>
            <pathway-xref db="Reactome" id="R-RNO-6811558" name="PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-6855" name="chitin degradation I (archaea)"/>
            <pathway-xref db="MetaCyc" id="PWY-7863" name="roseoflavin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-CEL-428542" name="Regulation of commissural axon pathfinding by SLIT and ROBO"/>
            <pathway-xref db="Reactome" id="R-HSA-6788467" name="IL-6-type cytokine receptor ligand interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-8957275" name="Post-translational protein phosphorylation"/>
            <pathway-xref db="Reactome" id="R-HSA-525793" name="Myogenesis"/>
            <pathway-xref db="Reactome" id="R-BTA-912694" name="Regulation of IFNA signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9706369" name="Negative regulation of FLT3"/>
            <pathway-xref db="Reactome" id="R-MMU-8957275" name="Post-translational protein phosphorylation"/>
            <pathway-xref db="Reactome" id="R-MMU-9706369" name="Negative regulation of FLT3"/>
            <pathway-xref db="Reactome" id="R-HSA-418889" name="Caspase activation via Dependence Receptors in the absence of ligand"/>
            <pathway-xref db="Reactome" id="R-HSA-8854691" name="Interleukin-20 family signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-6575" name="juvenile hormone III biosynthesis I"/>
            <pathway-xref db="Reactome" id="R-MMU-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-DME-373752" name="Netrin-1 signaling"/>
            <pathway-xref db="Reactome" id="R-DME-376172" name="DSCAM interactions"/>
            <pathway-xref db="Reactome" id="R-MMU-74751" name="Insulin receptor signalling cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-3928664" name="Ephrin signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9020958" name="Interleukin-21 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-182971" name="EGFR downregulation"/>
            <pathway-xref db="Reactome" id="R-MMU-210991" name="Basigin interactions"/>
            <pathway-xref db="Reactome" id="R-MMU-416700" name="Other semaphorin interactions"/>
            <pathway-xref db="Reactome" id="R-MMU-3214847" name="HATs acetylate histones"/>
            <pathway-xref db="Reactome" id="R-RNO-112411" name="MAPK1 (ERK2) activation"/>
            <pathway-xref db="Reactome" id="R-HSA-74713" name="IRS activation"/>
            <pathway-xref db="MetaCyc" id="PWY-7321" name="ecdysteroid metabolism (arthropods)"/>
            <pathway-xref db="Reactome" id="R-MMU-3928664" name="Ephrin signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-376172" name="DSCAM interactions"/>
            <pathway-xref db="Reactome" id="R-CEL-418885" name="DCC mediated attractive signaling"/>
            <pathway-xref db="Reactome" id="R-DME-209228" name="Formation of the activated STAT92E dimer and transport to the nucleus"/>
            <pathway-xref db="MetaCyc" id="PWY-6827" name="gellan degradation"/>
            <pathway-xref db="Reactome" id="R-CEL-351906" name="Apoptotic cleavage of cell adhesion proteins"/>
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            <pathway-xref db="Reactome" id="R-DME-209338" name="Assembly of the 'signalling complexes'"/>
            <pathway-xref db="Reactome" id="R-MMU-877312" name="Regulation of IFNG signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-7771" name="butachlor degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-449836" name="Other interleukin signaling"/>
            <pathway-xref db="Reactome" id="R-DME-5658623" name="FGFRL1 modulation of FGFR1 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-6724" name="starch degradation II"/>
            <pathway-xref db="Reactome" id="R-DRE-3214841" name="PKMTs methylate histone lysines"/>
            <pathway-xref db="Reactome" id="R-SSC-9020933" name="Interleukin-23 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-1474244" name="Extracellular matrix organization"/>
            <pathway-xref db="Reactome" id="R-RNO-114608" name="Platelet degranulation"/>
            <pathway-xref db="Reactome" id="R-MMU-216083" name="Integrin cell surface interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-181429" name="Serotonin Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-5635838" name="Activation of SMO"/>
            <pathway-xref db="Reactome" id="R-HSA-8856828" name="Clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-RNO-1266695" name="Interleukin-7 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-204005" name="COPII-mediated vesicle transport"/>
            <pathway-xref db="Reactome" id="R-HSA-8984722" name="Interleukin-35 Signalling"/>
            <pathway-xref db="Reactome" id="R-MMU-210993" name="Tie2 Signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-8984722" name="Interleukin-35 Signalling"/>
            <pathway-xref db="Reactome" id="R-HSA-163125" name="Post-translational modification: synthesis of GPI-anchored proteins"/>
            <pathway-xref db="Reactome" id="R-RNO-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-MMU-8856828" name="Clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-CEL-3928664" name="Ephrin signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-416482" name="G alpha (12/13) signalling events"/>
            <pathway-xref db="Reactome" id="R-MMU-264642" name="Acetylcholine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-3928662" name="EPHB-mediated forward signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-2586552" name="Signaling by Leptin"/>
            <pathway-xref db="Reactome" id="R-DME-388844" name="Receptor-type tyrosine-protein phosphatases"/>
            <pathway-xref db="Reactome" id="R-RNO-5173105" name="O-linked glycosylation"/>
            <pathway-xref db="Reactome" id="R-HSA-445144" name="Signal transduction by L1"/>
            <pathway-xref db="Reactome" id="R-GGA-8854691" name="Interleukin-20 family signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-196108" name="Pregnenolone biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-3928662" name="EPHB-mediated forward signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-5632681" name="Ligand-receptor interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-6785807" name="Interleukin-4 and Interleukin-13 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-3000178" name="ECM proteoglycans"/>
            <pathway-xref db="Reactome" id="R-MMU-181430" name="Norepinephrine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-CEL-418889" name="Caspase activation via Dependence Receptors in the absence of ligand"/>
            <pathway-xref db="Reactome" id="R-HSA-909733" name="Interferon alpha/beta signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-74713" name="IRS activation"/>
            <pathway-xref db="Reactome" id="R-RNO-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-2151201" name="Transcriptional activation of mitochondrial biogenesis"/>
            <pathway-xref db="Reactome" id="R-MMU-419037" name="NCAM1 interactions"/>
            <pathway-xref db="Reactome" id="R-RNO-373753" name="Nephrin family interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-186797" name="Signaling by PDGF"/>
            <pathway-xref db="Reactome" id="R-RNO-210500" name="Glutamate Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-9013404" name="RAC2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-CEL-376172" name="DSCAM interactions"/>
            <pathway-xref db="Reactome" id="R-MMU-9010553" name="Regulation of expression of SLITs and ROBOs"/>
            <pathway-xref db="Reactome" id="R-RNO-9027284" name="Erythropoietin activates RAS"/>
            <pathway-xref db="Reactome" id="R-CEL-2682334" name="EPH-Ephrin signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-419037" name="NCAM1 interactions"/>
            <pathway-xref db="Reactome" id="R-MMU-8985586" name="SLIT2:ROBO1 increases RHOA activity"/>
            <pathway-xref db="MetaCyc" id="PWY-6471" name="peptidoglycan biosynthesis IV (Enterococcus faecium)"/>
            <pathway-xref db="Reactome" id="R-MMU-9009391" name="Extra-nuclear estrogen signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-9020958" name="Interleukin-21 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-8948216" name="Collagen chain trimerization"/>
            <pathway-xref db="Reactome" id="R-MMU-9013424" name="RHOV GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-3214841" name="PKMTs methylate histone lysines"/>
            <pathway-xref db="Reactome" id="R-MMU-909733" name="Interferon alpha/beta signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-5687128" name="MAPK6/MAPK4 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-216083" name="Integrin cell surface interactions"/>
            <pathway-xref db="Reactome" id="R-RNO-1170546" name="Prolactin receptor signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-354194" name="GRB2:SOS provides linkage to MAPK signaling for Integrins"/>
            <pathway-xref db="Reactome" id="R-HSA-1059683" name="Interleukin-6 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-6811558" name="PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-354194" name="GRB2:SOS provides linkage to MAPK signaling for Integrins"/>
            <pathway-xref db="Reactome" id="R-CFA-1266695" name="Interleukin-7 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-2682334" name="EPH-Ephrin signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-437239" name="Recycling pathway of L1"/>
            <pathway-xref db="Reactome" id="R-HSA-1433557" name="Signaling by SCF-KIT"/>
            <pathway-xref db="MetaCyc" id="PWY-6148" name="tetrahydromethanopterin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6366" name="D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9656223" name="Signaling by RAF1 mutants"/>
            <pathway-xref db="Reactome" id="R-CEL-9013406" name="RHOQ GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-112411" name="MAPK1 (ERK2) activation"/>
            <pathway-xref db="Reactome" id="R-MMU-512988" name="Interleukin-3, Interleukin-5 and GM-CSF signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-6802955" name="Paradoxical activation of RAF signaling by kinase inactive BRAF"/>
            <pathway-xref db="Reactome" id="R-MMU-447043" name="Neurofascin interactions"/>
            <pathway-xref db="Reactome" id="R-MMU-9674555" name="Signaling by CSF3 (G-CSF)"/>
            <pathway-xref db="Reactome" id="R-MMU-416476" name="G alpha (q) signalling events"/>
            <pathway-xref db="Reactome" id="R-MMU-373760" name="L1CAM interactions"/>
            <pathway-xref db="Reactome" id="R-MMU-912694" name="Regulation of IFNA signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-204005" name="COPII-mediated vesicle transport"/>
            <pathway-xref db="Reactome" id="R-HSA-354192" name="Integrin signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-5627123" name="RHO GTPases activate PAKs"/>
            <pathway-xref db="Reactome" id="R-HSA-77387" name="Insulin receptor recycling"/>
            <pathway-xref db="Reactome" id="R-MMU-2428928" name="IRS-related events triggered by IGF1R"/>
            <pathway-xref db="Reactome" id="R-DRE-2682334" name="EPH-Ephrin signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9020933" name="Interleukin-23 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-2404192" name="Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)"/>
            <pathway-xref db="Reactome" id="R-DME-77387" name="Insulin receptor recycling"/>
            <pathway-xref db="Reactome" id="R-DRE-210993" name="Tie2 Signaling"/>
            <pathway-xref db="Reactome" id="R-DME-5632681" name="Ligand-receptor interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-2129379" name="Molecules associated with elastic fibres"/>
            <pathway-xref db="Reactome" id="R-RNO-1474228" name="Degradation of the extracellular matrix"/>
            <pathway-xref db="MetaCyc" id="PWY-8119" name="microcin B17 biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-877312" name="Regulation of IFNG signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-6991" name="(-)-camphor biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-5654687" name="Downstream signaling of activated FGFR1"/>
            <pathway-xref db="Reactome" id="R-HSA-428543" name="Inactivation of CDC42 and RAC1"/>
            <pathway-xref db="Reactome" id="R-MMU-182971" name="EGFR downregulation"/>
            <pathway-xref db="Reactome" id="R-MMU-375165" name="NCAM signaling for neurite out-growth"/>
            <pathway-xref db="Reactome" id="R-CEL-3928665" name="EPH-ephrin mediated repulsion of cells"/>
            <pathway-xref db="Reactome" id="R-MMU-196108" name="Pregnenolone biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-5687128" name="MAPK6/MAPK4 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-1442490" name="Collagen degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-1650814" name="Collagen biosynthesis and modifying enzymes"/>
            <pathway-xref db="Reactome" id="R-CFA-8985947" name="Interleukin-9 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-8849932" name="Synaptic adhesion-like molecules"/>
            <pathway-xref db="Reactome" id="R-MMU-2404192" name="Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)"/>
            <pathway-xref db="Reactome" id="R-GGA-449836" name="Other interleukin signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-5673001" name="RAF/MAP kinase cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-912526" name="Interleukin receptor SHC signaling"/>
            <pathway-xref db="Reactome" id="R-CEL-9013420" name="RHOU GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-5674135" name="MAP2K and MAPK activation"/>
            <pathway-xref db="Reactome" id="R-RNO-216083" name="Integrin cell surface interactions"/>
            <pathway-xref db="Reactome" id="R-RNO-445144" name="Signal transduction by L1"/>
            <pathway-xref db="Reactome" id="R-MMU-112411" name="MAPK1 (ERK2) activation"/>
            <pathway-xref db="Reactome" id="R-MMU-9705462" name="Inactivation of CSF3 (G-CSF) signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-9696264" name="RND3 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-74751" name="Insulin receptor signalling cascade"/>
            <pathway-xref db="Reactome" id="R-MMU-9696270" name="RND2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-418886" name="Netrin mediated repulsion signals"/>
            <pathway-xref db="Reactome" id="R-HSA-190373" name="FGFR1c ligand binding and activation"/>
            <pathway-xref db="Reactome" id="R-RNO-912526" name="Interleukin receptor SHC signaling"/>
            <pathway-xref db="Reactome" id="R-DRE-5673001" name="RAF/MAP kinase cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-9696273" name="RND1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-1474244" name="Extracellular matrix organization"/>
            <pathway-xref db="MetaCyc" id="PWY-6456" name="serinol biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-2214320" name="Anchoring fibril formation"/>
            <pathway-xref db="Reactome" id="R-RNO-9009391" name="Extra-nuclear estrogen signaling"/>
            <pathway-xref db="Reactome" id="R-CFA-9020958" name="Interleukin-21 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9027276" name="Erythropoietin activates Phosphoinositide-3-kinase (PI3K)"/>
            <pathway-xref db="Reactome" id="R-HSA-5683826" name="Surfactant metabolism"/>
            <pathway-xref db="Reactome" id="R-RNO-388844" name="Receptor-type tyrosine-protein phosphatases"/>
            <pathway-xref db="Reactome" id="R-MMU-982772" name="Growth hormone receptor signaling"/>
            <pathway-xref db="Reactome" id="R-DME-525793" name="Myogenesis"/>
            <pathway-xref db="Reactome" id="R-CEL-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-5173105" name="O-linked glycosylation"/>
            <pathway-xref db="Reactome" id="R-RNO-8984722" name="Interleukin-35 Signalling"/>
            <pathway-xref db="Reactome" id="R-HSA-9031628" name="NGF-stimulated transcription"/>
            <pathway-xref db="Reactome" id="R-MMU-5635838" name="Activation of SMO"/>
            <pathway-xref db="Reactome" id="R-HSA-447043" name="Neurofascin interactions"/>
            <pathway-xref db="Reactome" id="R-MMU-354192" name="Integrin signaling"/>
            <pathway-xref db="Reactome" id="R-CEL-9013149" name="RAC1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DRE-3928662" name="EPHB-mediated forward signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9020558" name="Interleukin-2 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-3928664" name="Ephrin signaling"/>
            <pathway-xref db="Reactome" id="R-CEL-3928663" name="EPHA-mediated growth cone collapse"/>
            <pathway-xref db="Reactome" id="R-HSA-373760" name="L1CAM interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-8951664" name="Neddylation"/>
            <pathway-xref db="Reactome" id="R-MMU-3928663" name="EPHA-mediated growth cone collapse"/>
            <pathway-xref db="Reactome" id="R-RNO-3928662" name="EPHB-mediated forward signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-5694530" name="Cargo concentration in the ER"/>
            <pathway-xref db="Reactome" id="R-HSA-446107" name="Type I hemidesmosome assembly"/>
            <pathway-xref db="Reactome" id="R-HSA-1266695" name="Interleukin-7 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-74713" name="IRS activation"/>
            <pathway-xref db="MetaCyc" id="PWY-6627" name="salinosporamide A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-9027284" name="Erythropoietin activates RAS"/>
            <pathway-xref db="MetaCyc" id="PWY-6720" name="toyocamycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-CEL-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-HSA-449836" name="Other interleukin signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-140834" name="Extrinsic Pathway of Fibrin Clot Formation"/>
            <pathway-xref db="Reactome" id="R-HSA-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-RNO-3000178" name="ECM proteoglycans"/>
            <pathway-xref db="Reactome" id="R-DRE-3928664" name="Ephrin signaling"/>
            <pathway-xref db="Reactome" id="R-CEL-9013424" name="RHOV GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-9013423" name="RAC3 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-381426" name="Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"/>
            <pathway-xref db="Reactome" id="R-DME-5689603" name="UCH proteinases"/>
            <pathway-xref db="Reactome" id="R-HSA-5632681" name="Ligand-receptor interactions"/>
            <pathway-xref db="Reactome" id="R-MMU-9013420" name="RHOU GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-9013149" name="RAC1 GTPase cycle"/>
          </entry>
          <signature-library-release library="CDD" version="3.18"/>
        </signature>
        <model-ac>cd00063</model-ac>
        <locations>
          <rpsblast-location evalue="1.40106E-10" score="57.1211" start="132" end="210">
            <location-fragments>
              <rpsblast-location-fragment start="132" end="210" dc-status="CONTINUOUS"/>
            </location-fragments>
            <sites>
              <rpsblast-site description="Cytokine receptor motif" numLocations="4">
                <site-locations>
                  <site-location residue="T" start="203" end="203"/>
                  <site-location residue="Y" start="202" end="202"/>
                  <site-location residue="A" start="199" end="199"/>
                  <site-location residue="G" start="200" end="200"/>
                </site-locations>
              </rpsblast-site>
            </sites>
          </rpsblast-location>
        </locations>
      </rpsblast-match>
      <rpsblast-match>
        <signature ac="cd00063" desc="FN3" name="FN3">
          <entry ac="IPR003961" desc="Fibronectin type III" name="FN3_dom" type="DOMAIN">
            <go-xref category="MOLECULAR_FUNCTION" db="GO" id="GO:0005515" name="protein binding"/>
            <pathway-xref db="Reactome" id="R-HSA-74749" name="Signal attenuation"/>
            <pathway-xref db="Reactome" id="R-MMU-1474228" name="Degradation of the extracellular matrix"/>
            <pathway-xref db="Reactome" id="R-HSA-202733" name="Cell surface interactions at the vascular wall"/>
            <pathway-xref db="Reactome" id="R-HSA-5673001" name="RAF/MAP kinase cascade"/>
            <pathway-xref db="Reactome" id="R-DME-428542" name="Regulation of commissural axon pathfinding by SLIT and ROBO"/>
            <pathway-xref db="Reactome" id="R-HSA-447038" name="NrCAM interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-1474228" name="Degradation of the extracellular matrix"/>
            <pathway-xref db="Reactome" id="R-CEL-373752" name="Netrin-1 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-2428928" name="IRS-related events triggered by IGF1R"/>
            <pathway-xref db="Reactome" id="R-MMU-877300" name="Interferon gamma signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-525793" name="Myogenesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9649948" name="Signaling downstream of RAS mutants"/>
            <pathway-xref db="Reactome" id="R-MMU-8874081" name="MET activates PTK2 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-6902" name="chitin degradation II (Vibrio)"/>
            <pathway-xref db="Reactome" id="R-MMU-445095" name="Interaction between L1 and Ankyrins"/>
            <pathway-xref db="Reactome" id="R-RNO-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-264642" name="Acetylcholine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-3000157" name="Laminin interactions"/>
            <pathway-xref db="Reactome" id="R-MMU-210500" name="Glutamate Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-76009" name="Platelet Aggregation (Plug Formation)"/>
            <pathway-xref db="Reactome" id="R-MMU-8951664" name="Neddylation"/>
            <pathway-xref db="Reactome" id="R-GGA-3928663" name="EPHA-mediated growth cone collapse"/>
            <pathway-xref db="Reactome" id="R-RNO-181430" name="Norepinephrine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-8854691" name="Interleukin-20 family signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-7881" name="virginiae butanolide type gamma-butyrolactones biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-5673001" name="RAF/MAP kinase cascade"/>
            <pathway-xref db="Reactome" id="R-MMU-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-DME-447043" name="Neurofascin interactions"/>
            <pathway-xref db="Reactome" id="R-RNO-2129379" name="Molecules associated with elastic fibres"/>
            <pathway-xref db="Reactome" id="R-HSA-2682334" name="EPH-Ephrin signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-6368" name="3-phosphoinositide degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-2022090" name="Assembly of collagen fibrils and other multimeric structures"/>
            <pathway-xref db="Reactome" id="R-HSA-373753" name="Nephrin family interactions"/>
            <pathway-xref db="Reactome" id="R-MMU-5683826" name="Surfactant metabolism"/>
            <pathway-xref db="Reactome" id="R-RNO-2428933" name="SHC-related events triggered by IGF1R"/>
            <pathway-xref db="Reactome" id="R-HSA-9020591" name="Interleukin-12 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-6955" name="lincomycin A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-3928665" name="EPH-ephrin mediated repulsion of cells"/>
            <pathway-xref db="MetaCyc" id="PWY-6352" name="3-phosphoinositide biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-74749" name="Signal attenuation"/>
            <pathway-xref db="MetaCyc" id="PWY-7882" name="IM-2 type gamma-butyrolactones biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6990" name="(+)-camphor biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-HSA-5674135" name="MAP2K and MAPK activation"/>
            <pathway-xref db="MetaCyc" id="PWY-4702" name="phytate degradation I"/>
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            <pathway-xref db="Reactome" id="R-RNO-8849932" name="Synaptic adhesion-like molecules"/>
            <pathway-xref db="Reactome" id="R-CFA-912526" name="Interleukin receptor SHC signaling"/>
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            <pathway-xref db="Reactome" id="R-HSA-8985947" name="Interleukin-9 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-1059683" name="Interleukin-6 signaling"/>
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            <pathway-xref db="Reactome" id="R-RNO-196108" name="Pregnenolone biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-MMU-418889" name="Caspase activation via Dependence Receptors in the absence of ligand"/>
            <pathway-xref db="MetaCyc" id="PWY-7246" name="pectin degradation I"/>
            <pathway-xref db="Reactome" id="R-MMU-9020956" name="Interleukin-27 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9020956" name="Interleukin-27 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-5688849" name="Defective CSF2RB causes SMDP5"/>
            <pathway-xref db="MetaCyc" id="PWY-7511" name="protein ubiquitination"/>
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            <pathway-xref db="Reactome" id="R-HSA-210500" name="Glutamate Neurotransmitter Release Cycle"/>
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            <pathway-xref db="MetaCyc" id="PWY-6348" name="phosphate acquisition"/>
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            <pathway-xref db="MetaCyc" id="PWY-6788" name="cellulose degradation II (fungi)"/>
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            <pathway-xref db="MetaCyc" id="PWY-6686" name="mannosylglucosylglycerate biosynthesis I"/>
            <pathway-xref db="MetaCyc" id="PWY-8052" name="2-arachidonoylglycerol biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-MMU-1170546" name="Prolactin receptor signaling"/>
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            <pathway-xref db="Reactome" id="R-RNO-8951664" name="Neddylation"/>
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            <pathway-xref db="Reactome" id="R-MMU-445355" name="Smooth Muscle Contraction"/>
            <pathway-xref db="Reactome" id="R-HSA-2428928" name="IRS-related events triggered by IGF1R"/>
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            <pathway-xref db="Reactome" id="R-RNO-9020558" name="Interleukin-2 signaling"/>
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            <pathway-xref db="Reactome" id="R-CEL-5218920" name="VEGFR2 mediated vascular permeability"/>
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            <pathway-xref db="MetaCyc" id="PWY-8282" name="adenosylcobinamide-GDP salvage from assorted adenosylcobamides"/>
            <pathway-xref db="Reactome" id="R-MMU-373752" name="Netrin-1 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-354192" name="Integrin signaling"/>
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            <pathway-xref db="Reactome" id="R-MMU-6783783" name="Interleukin-10 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-193648" name="NRAGE signals death through JNK"/>
            <pathway-xref db="Reactome" id="R-HSA-376176" name="Signaling by ROBO receptors"/>
            <pathway-xref db="Reactome" id="R-MMU-3000157" name="Laminin interactions"/>
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            <pathway-xref db="MetaCyc" id="PWY-7771" name="butachlor degradation"/>
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            <pathway-xref db="MetaCyc" id="PWY-6724" name="starch degradation II"/>
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            <pathway-xref db="Reactome" id="R-SSC-9020933" name="Interleukin-23 signaling"/>
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            <pathway-xref db="Reactome" id="R-MMU-264642" name="Acetylcholine Neurotransmitter Release Cycle"/>
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            <pathway-xref db="Reactome" id="R-HSA-2586552" name="Signaling by Leptin"/>
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            <pathway-xref db="Reactome" id="R-GGA-8854691" name="Interleukin-20 family signaling"/>
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            <pathway-xref db="Reactome" id="R-RNO-5632681" name="Ligand-receptor interactions"/>
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            <pathway-xref db="Reactome" id="R-RNO-210500" name="Glutamate Neurotransmitter Release Cycle"/>
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            <pathway-xref db="Reactome" id="R-MMU-9020958" name="Interleukin-21 signaling"/>
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            <pathway-xref db="Reactome" id="R-RNO-1170546" name="Prolactin receptor signaling"/>
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            <pathway-xref db="Reactome" id="R-CFA-1266695" name="Interleukin-7 signaling"/>
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            <pathway-xref db="Reactome" id="R-CEL-9013406" name="RHOQ GTPase cycle"/>
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            <pathway-xref db="Reactome" id="R-DME-77387" name="Insulin receptor recycling"/>
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            <pathway-xref db="Reactome" id="R-MMU-196108" name="Pregnenolone biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-MMU-1442490" name="Collagen degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-1650814" name="Collagen biosynthesis and modifying enzymes"/>
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            <pathway-xref db="Reactome" id="R-MMU-8849932" name="Synaptic adhesion-like molecules"/>
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            <pathway-xref db="Reactome" id="R-CEL-9013420" name="RHOU GTPase cycle"/>
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            <pathway-xref db="Reactome" id="R-RNO-216083" name="Integrin cell surface interactions"/>
            <pathway-xref db="Reactome" id="R-RNO-445144" name="Signal transduction by L1"/>
            <pathway-xref db="Reactome" id="R-MMU-112411" name="MAPK1 (ERK2) activation"/>
            <pathway-xref db="Reactome" id="R-MMU-9705462" name="Inactivation of CSF3 (G-CSF) signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-9696264" name="RND3 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-74751" name="Insulin receptor signalling cascade"/>
            <pathway-xref db="Reactome" id="R-MMU-9696270" name="RND2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-418886" name="Netrin mediated repulsion signals"/>
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            <pathway-xref db="Reactome" id="R-RNO-912526" name="Interleukin receptor SHC signaling"/>
            <pathway-xref db="Reactome" id="R-DRE-5673001" name="RAF/MAP kinase cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-9696273" name="RND1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-1474244" name="Extracellular matrix organization"/>
            <pathway-xref db="MetaCyc" id="PWY-6456" name="serinol biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-RNO-9009391" name="Extra-nuclear estrogen signaling"/>
            <pathway-xref db="Reactome" id="R-CFA-9020958" name="Interleukin-21 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9027276" name="Erythropoietin activates Phosphoinositide-3-kinase (PI3K)"/>
            <pathway-xref db="Reactome" id="R-HSA-5683826" name="Surfactant metabolism"/>
            <pathway-xref db="Reactome" id="R-RNO-388844" name="Receptor-type tyrosine-protein phosphatases"/>
            <pathway-xref db="Reactome" id="R-MMU-982772" name="Growth hormone receptor signaling"/>
            <pathway-xref db="Reactome" id="R-DME-525793" name="Myogenesis"/>
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            <pathway-xref db="Reactome" id="R-HSA-5173105" name="O-linked glycosylation"/>
            <pathway-xref db="Reactome" id="R-RNO-8984722" name="Interleukin-35 Signalling"/>
            <pathway-xref db="Reactome" id="R-HSA-9031628" name="NGF-stimulated transcription"/>
            <pathway-xref db="Reactome" id="R-MMU-5635838" name="Activation of SMO"/>
            <pathway-xref db="Reactome" id="R-HSA-447043" name="Neurofascin interactions"/>
            <pathway-xref db="Reactome" id="R-MMU-354192" name="Integrin signaling"/>
            <pathway-xref db="Reactome" id="R-CEL-9013149" name="RAC1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DRE-3928662" name="EPHB-mediated forward signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9020558" name="Interleukin-2 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-3928664" name="Ephrin signaling"/>
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            <pathway-xref db="Reactome" id="R-HSA-373760" name="L1CAM interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-8951664" name="Neddylation"/>
            <pathway-xref db="Reactome" id="R-MMU-3928663" name="EPHA-mediated growth cone collapse"/>
            <pathway-xref db="Reactome" id="R-RNO-3928662" name="EPHB-mediated forward signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-5694530" name="Cargo concentration in the ER"/>
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            <pathway-xref db="Reactome" id="R-HSA-1266695" name="Interleukin-7 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-74713" name="IRS activation"/>
            <pathway-xref db="MetaCyc" id="PWY-6627" name="salinosporamide A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-9027284" name="Erythropoietin activates RAS"/>
            <pathway-xref db="MetaCyc" id="PWY-6720" name="toyocamycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-CEL-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-HSA-449836" name="Other interleukin signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-140834" name="Extrinsic Pathway of Fibrin Clot Formation"/>
            <pathway-xref db="Reactome" id="R-HSA-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-RNO-3000178" name="ECM proteoglycans"/>
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            <pathway-xref db="Reactome" id="R-HSA-5632681" name="Ligand-receptor interactions"/>
            <pathway-xref db="Reactome" id="R-MMU-9013420" name="RHOU GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-9013149" name="RAC1 GTPase cycle"/>
          </entry>
          <signature-library-release library="CDD" version="3.18"/>
        </signature>
        <model-ac>cd00063</model-ac>
        <locations>
          <rpsblast-location evalue="3.46497E-8" score="50.1875" start="729" end="806">
            <location-fragments>
              <rpsblast-location-fragment start="729" end="806" dc-status="CONTINUOUS"/>
            </location-fragments>
            <sites/>
          </rpsblast-location>
        </locations>
      </rpsblast-match>
      <superfamilyhmmer3-match evalue="8.59E-71">
        <signature ac="SSF56112" name="Protein kinase-like (PK-like)">
          <entry ac="IPR011009" desc="Protein kinase-like domain superfamily" name="Kinase-like_dom_sf" type="HOMOLOGOUS_SUPERFAMILY">
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            <pathway-xref db="Reactome" id="R-MMU-2173791" name="TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)"/>
            <pathway-xref db="Reactome" id="R-DRE-418885" name="DCC mediated attractive signaling"/>
            <pathway-xref db="Reactome" id="R-BTA-389356" name="CD28 co-stimulation"/>
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            <pathway-xref db="Reactome" id="R-HSA-5673001" name="RAF/MAP kinase cascade"/>
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            <pathway-xref db="Reactome" id="R-MMU-5620912" name="Anchoring of the basal body to the plasma membrane"/>
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            <pathway-xref db="Reactome" id="R-DRE-372708" name="p130Cas linkage to MAPK signaling for integrins"/>
            <pathway-xref db="MetaCyc" id="PWY-7049" name="icosapentaenoate biosynthesis II (6-desaturase, mammals)"/>
            <pathway-xref db="Reactome" id="R-MMU-6791226" name="Major pathway of rRNA processing in the nucleolus and cytosol"/>
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            <pathway-xref db="Reactome" id="R-DME-4420097" name="VEGFA-VEGFR2 Pathway"/>
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            <pathway-xref db="Reactome" id="R-MMU-1170546" name="Prolactin receptor signaling"/>
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            <pathway-xref db="Reactome" id="R-CFA-4086398" name="Ca2+ pathway"/>
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            <pathway-xref db="Reactome" id="R-BTA-109704" name="PI3K Cascade"/>
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            <pathway-xref db="Reactome" id="R-PFA-5610787" name="Hedgehog 'off' state"/>
            <pathway-xref db="Reactome" id="R-HSA-109704" name="PI3K Cascade"/>
            <pathway-xref db="Reactome" id="R-CEL-177929" name="Signaling by EGFR"/>
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            <pathway-xref db="Reactome" id="R-MMU-72086" name="mRNA Capping"/>
            <pathway-xref db="Reactome" id="R-CEL-68884" name="Mitotic Telophase/Cytokinesis"/>
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            <pathway-xref db="Reactome" id="R-CEL-430116" name="GP1b-IX-V activation signalling"/>
            <pathway-xref db="Reactome" id="R-DME-9013407" name="RHOH GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DME-392451" name="G beta:gamma signalling through PI3Kgamma"/>
            <pathway-xref db="Reactome" id="R-DRE-210990" name="PECAM1 interactions"/>
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            <pathway-xref db="Reactome" id="R-HSA-68911" name="G2 Phase"/>
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            <pathway-xref db="Reactome" id="R-HSA-975871" name="MyD88 cascade initiated on plasma membrane"/>
            <pathway-xref db="Reactome" id="R-CEL-5673001" name="RAF/MAP kinase cascade"/>
            <pathway-xref db="Reactome" id="R-DRE-380270" name="Recruitment of mitotic centrosome proteins and complexes"/>
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        <model-ac>0043269</model-ac>
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      <superfamilyhmmer3-match evalue="9.53E-15">
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            <pathway-xref db="Reactome" id="R-MMU-9009391" name="Extra-nuclear estrogen signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-9020958" name="Interleukin-21 signaling"/>
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          <superfamilyhmmer3-location hmm-length="196" start="625" end="805">
            <location-fragments>
              <superfamilyhmmer3-location-fragment start="625" end="805" dc-status="CONTINUOUS"/>
            </location-fragments>
          </superfamilyhmmer3-location>
        </locations>
      </superfamilyhmmer3-match>
      <superfamilyhmmer3-match evalue="5.89E-5">
        <signature ac="SSF63825" name="YWTD domain">
          <signature-library-release library="SUPERFAMILY" version="1.75"/>
        </signature>
        <model-ac>0047378</model-ac>
        <locations>
          <superfamilyhmmer3-location hmm-length="266" start="290" end="468">
            <location-fragments>
              <superfamilyhmmer3-location-fragment start="290" end="468" dc-status="CONTINUOUS"/>
            </location-fragments>
          </superfamilyhmmer3-location>
        </locations>
      </superfamilyhmmer3-match>
      <superfamilyhmmer3-match evalue="2.8E-16">
        <signature ac="SSF49265" name="Fibronectin type III">
          <entry ac="IPR036116" desc="Fibronectin type III superfamily" name="FN3_sf" type="HOMOLOGOUS_SUPERFAMILY">
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            <pathway-xref db="Reactome" id="R-MMU-1474228" name="Degradation of the extracellular matrix"/>
            <pathway-xref db="Reactome" id="R-HSA-202733" name="Cell surface interactions at the vascular wall"/>
            <pathway-xref db="Reactome" id="R-DME-110478" name="Insulin signaling pathway"/>
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            <pathway-xref db="Reactome" id="R-HSA-437239" name="Recycling pathway of L1"/>
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            <pathway-xref db="Reactome" id="R-MMU-1170546" name="Prolactin receptor signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-912526" name="Interleukin receptor SHC signaling"/>
            <pathway-xref db="Reactome" id="R-CEL-416482" name="G alpha (12/13) signalling events"/>
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            <pathway-xref db="Reactome" id="R-HSA-1170546" name="Prolactin receptor signaling"/>
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            <pathway-xref db="Reactome" id="R-HSA-9027283" name="Erythropoietin activates STAT5"/>
            <pathway-xref db="MetaCyc" id="PWY-7119" name="ceramide and sphingolipid recycling and degradation (yeast)"/>
            <pathway-xref db="Reactome" id="R-CEL-373756" name="SDK interactions"/>
            <pathway-xref db="Reactome" id="R-CFA-9020558" name="Interleukin-2 signaling"/>
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            <pathway-xref db="Reactome" id="R-RNO-8983432" name="Interleukin-15 signaling"/>
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            <pathway-xref db="Reactome" id="R-MMU-446107" name="Type I hemidesmosome assembly"/>
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            <pathway-xref db="Reactome" id="R-BTA-140834" name="Extrinsic Pathway of Fibrin Clot Formation"/>
            <pathway-xref db="Reactome" id="R-MMU-445355" name="Smooth Muscle Contraction"/>
            <pathway-xref db="Reactome" id="R-HSA-2428928" name="IRS-related events triggered by IGF1R"/>
            <pathway-xref db="Reactome" id="R-HSA-3214847" name="HATs acetylate histones"/>
            <pathway-xref db="Reactome" id="R-SSC-9027284" name="Erythropoietin activates RAS"/>
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            <pathway-xref db="Reactome" id="R-RNO-9020558" name="Interleukin-2 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-212676" name="Dopamine Neurotransmitter Release Cycle"/>
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            <pathway-xref db="Reactome" id="R-MMU-418885" name="DCC mediated attractive signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-2122948" name="Activated NOTCH1 Transmits Signal to the Nucleus"/>
            <pathway-xref db="Reactome" id="R-MMU-140834" name="Extrinsic Pathway of Fibrin Clot Formation"/>
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            <pathway-xref db="Reactome" id="R-CEL-5218920" name="VEGFR2 mediated vascular permeability"/>
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            <pathway-xref db="MetaCyc" id="PWY-8282" name="adenosylcobinamide-GDP salvage from assorted adenosylcobamides"/>
            <pathway-xref db="Reactome" id="R-MMU-428890" name="Role of ABL in ROBO-SLIT signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-9013408" name="RHOG GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-446107" name="Type I hemidesmosome assembly"/>
            <pathway-xref db="Reactome" id="R-DME-209209" name="Formation of the activated receptor complex"/>
            <pathway-xref db="Reactome" id="R-MMU-373752" name="Netrin-1 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-354192" name="Integrin signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-390522" name="Striated Muscle Contraction"/>
            <pathway-xref db="Reactome" id="R-HSA-1566977" name="Fibronectin matrix formation"/>
            <pathway-xref db="Reactome" id="R-RNO-390522" name="Striated Muscle Contraction"/>
            <pathway-xref db="Reactome" id="R-HSA-445355" name="Smooth Muscle Contraction"/>
            <pathway-xref db="Reactome" id="R-HSA-6802948" name="Signaling by high-kinase activity BRAF mutants"/>
            <pathway-xref db="Reactome" id="R-RNO-212676" name="Dopamine Neurotransmitter Release Cycle"/>
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            <pathway-xref db="Reactome" id="R-MMU-6783783" name="Interleukin-10 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-140834" name="Extrinsic Pathway of Fibrin Clot Formation"/>
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            <pathway-xref db="Reactome" id="R-HSA-376176" name="Signaling by ROBO receptors"/>
            <pathway-xref db="Reactome" id="R-MMU-3000157" name="Laminin interactions"/>
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            <pathway-xref db="Reactome" id="R-DME-209338" name="Assembly of the 'signalling complexes'"/>
            <pathway-xref db="Reactome" id="R-MMU-877312" name="Regulation of IFNG signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-7771" name="butachlor degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-912694" name="Regulation of IFNA signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-449836" name="Other interleukin signaling"/>
            <pathway-xref db="Reactome" id="R-DME-5658623" name="FGFRL1 modulation of FGFR1 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-6788467" name="IL-6-type cytokine receptor ligand interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-9006335" name="Signaling by Erythropoietin"/>
            <pathway-xref db="MetaCyc" id="PWY-6724" name="starch degradation II"/>
            <pathway-xref db="Reactome" id="R-DRE-3214841" name="PKMTs methylate histone lysines"/>
            <pathway-xref db="Reactome" id="R-SSC-9020933" name="Interleukin-23 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-375165" name="NCAM signaling for neurite out-growth"/>
            <pathway-xref db="Reactome" id="R-RNO-6811558" name="PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-6855" name="chitin degradation I (archaea)"/>
            <pathway-xref db="Reactome" id="R-HSA-1474244" name="Extracellular matrix organization"/>
            <pathway-xref db="MetaCyc" id="PWY-7863" name="roseoflavin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-114608" name="Platelet degranulation"/>
            <pathway-xref db="Reactome" id="R-HSA-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-CEL-428542" name="Regulation of commissural axon pathfinding by SLIT and ROBO"/>
            <pathway-xref db="Reactome" id="R-MMU-216083" name="Integrin cell surface interactions"/>
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            <pathway-xref db="Reactome" id="R-RNO-5635838" name="Activation of SMO"/>
            <pathway-xref db="Reactome" id="R-HSA-8856828" name="Clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-HSA-6788467" name="IL-6-type cytokine receptor ligand interactions"/>
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            <pathway-xref db="MetaCyc" id="PWY-6575" name="juvenile hormone III biosynthesis I"/>
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            <pathway-xref db="Reactome" id="R-GGA-8854691" name="Interleukin-20 family signaling"/>
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            <pathway-xref db="MetaCyc" id="PWY-6827" name="gellan degradation"/>
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            <pathway-xref db="Reactome" id="R-CEL-418889" name="Caspase activation via Dependence Receptors in the absence of ligand"/>
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            <pathway-xref db="Reactome" id="R-MMU-6785807" name="Interleukin-4 and Interleukin-13 signaling"/>
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            <pathway-xref db="Reactome" id="R-HSA-181430" name="Norepinephrine Neurotransmitter Release Cycle"/>
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            <pathway-xref db="Reactome" id="R-BTA-909733" name="Interferon alpha/beta signaling"/>
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            <pathway-xref db="Reactome" id="R-MMU-909733" name="Interferon alpha/beta signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-264642" name="Acetylcholine Neurotransmitter Release Cycle"/>
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            <pathway-xref db="Reactome" id="R-CEL-388844" name="Receptor-type tyrosine-protein phosphatases"/>
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            <pathway-xref db="Reactome" id="R-RNO-1170546" name="Prolactin receptor signaling"/>
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            <pathway-xref db="Reactome" id="R-RNO-110056" name="MAPK3 (ERK1) activation"/>
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            <pathway-xref db="Reactome" id="R-MMU-1433557" name="Signaling by SCF-KIT"/>
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            <pathway-xref db="Reactome" id="R-CFA-1266695" name="Interleukin-7 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-1059683" name="Interleukin-6 signaling"/>
            <pathway-xref db="Reactome" id="R-DME-418889" name="Caspase activation via Dependence Receptors in the absence of ligand"/>
            <pathway-xref db="Reactome" id="R-RNO-2682334" name="EPH-Ephrin signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-437239" name="Recycling pathway of L1"/>
            <pathway-xref db="Reactome" id="R-MMU-9027276" name="Erythropoietin activates Phosphoinositide-3-kinase (PI3K)"/>
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            <pathway-xref db="Reactome" id="R-HSA-447041" name="CHL1 interactions"/>
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            <pathway-xref db="MetaCyc" id="PWY-6366" name="D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-CEL-9013406" name="RHOQ GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-112411" name="MAPK1 (ERK2) activation"/>
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            <pathway-xref db="Reactome" id="R-HSA-77387" name="Insulin receptor recycling"/>
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            <pathway-xref db="Reactome" id="R-RNO-2404192" name="Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)"/>
            <pathway-xref db="Reactome" id="R-DME-77387" name="Insulin receptor recycling"/>
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            <pathway-xref db="Reactome" id="R-HSA-1650814" name="Collagen biosynthesis and modifying enzymes"/>
            <pathway-xref db="Reactome" id="R-DME-5632681" name="Ligand-receptor interactions"/>
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            <pathway-xref db="Reactome" id="R-RNO-77387" name="Insulin receptor recycling"/>
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            <pathway-xref db="Reactome" id="R-MMU-8980692" name="RHOA GTPase cycle"/>
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            <pathway-xref db="Reactome" id="R-MMU-1650814" name="Collagen biosynthesis and modifying enzymes"/>
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            <pathway-xref db="Reactome" id="R-DME-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-CEL-9013420" name="RHOU GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-9616222" name="Transcriptional regulation of granulopoiesis"/>
            <pathway-xref db="Reactome" id="R-RNO-5674135" name="MAP2K and MAPK activation"/>
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            <pathway-xref db="Reactome" id="R-RNO-445144" name="Signal transduction by L1"/>
            <pathway-xref db="Reactome" id="R-MMU-1266695" name="Interleukin-7 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-6365" name="D-myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-112411" name="MAPK1 (ERK2) activation"/>
            <pathway-xref db="Reactome" id="R-HSA-9705462" name="Inactivation of CSF3 (G-CSF) signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-210991" name="Basigin interactions"/>
            <pathway-xref db="Reactome" id="R-MMU-445144" name="Signal transduction by L1"/>
            <pathway-xref db="Reactome" id="R-MMU-9705462" name="Inactivation of CSF3 (G-CSF) signaling"/>
            <pathway-xref db="Reactome" id="R-CEL-77387" name="Insulin receptor recycling"/>
            <pathway-xref db="Reactome" id="R-DME-9009391" name="Extra-nuclear estrogen signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-9696264" name="RND3 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-74751" name="Insulin receptor signalling cascade"/>
            <pathway-xref db="Reactome" id="R-MMU-9696270" name="RND2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-418886" name="Netrin mediated repulsion signals"/>
            <pathway-xref db="Reactome" id="R-HSA-190373" name="FGFR1c ligand binding and activation"/>
            <pathway-xref db="Reactome" id="R-RNO-912526" name="Interleukin receptor SHC signaling"/>
            <pathway-xref db="Reactome" id="R-DRE-5673001" name="RAF/MAP kinase cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-9696273" name="RND1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-1474244" name="Extracellular matrix organization"/>
            <pathway-xref db="Reactome" id="R-HSA-8849932" name="Synaptic adhesion-like molecules"/>
            <pathway-xref db="MetaCyc" id="PWY-6456" name="serinol biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-2214320" name="Anchoring fibril formation"/>
            <pathway-xref db="Reactome" id="R-RNO-9009391" name="Extra-nuclear estrogen signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-445095" name="Interaction between L1 and Ankyrins"/>
            <pathway-xref db="Reactome" id="R-CFA-9020958" name="Interleukin-21 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-1442490" name="Collagen degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-9027276" name="Erythropoietin activates Phosphoinositide-3-kinase (PI3K)"/>
            <pathway-xref db="Reactome" id="R-RNO-418889" name="Caspase activation via Dependence Receptors in the absence of ligand"/>
            <pathway-xref db="Reactome" id="R-HSA-5683826" name="Surfactant metabolism"/>
            <pathway-xref db="Reactome" id="R-RNO-388844" name="Receptor-type tyrosine-protein phosphatases"/>
            <pathway-xref db="Reactome" id="R-HSA-5687128" name="MAPK6/MAPK4 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-7437" name="protein O-[N-acetyl]-glucosylation"/>
            <pathway-xref db="Reactome" id="R-MMU-202427" name="Phosphorylation of CD3 and TCR zeta chains"/>
            <pathway-xref db="Reactome" id="R-DME-210688" name="Dephosphorylation by PTP61F phosphatases"/>
            <pathway-xref db="Reactome" id="R-MMU-982772" name="Growth hormone receptor signaling"/>
            <pathway-xref db="Reactome" id="R-DME-525793" name="Myogenesis"/>
            <pathway-xref db="Reactome" id="R-RNO-8957275" name="Post-translational protein phosphorylation"/>
            <pathway-xref db="Reactome" id="R-MMU-525793" name="Myogenesis"/>
            <pathway-xref db="Reactome" id="R-CEL-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-5173105" name="O-linked glycosylation"/>
            <pathway-xref db="Reactome" id="R-RNO-8984722" name="Interleukin-35 Signalling"/>
            <pathway-xref db="Reactome" id="R-HSA-9031628" name="NGF-stimulated transcription"/>
            <pathway-xref db="Reactome" id="R-MMU-163125" name="Post-translational modification: synthesis of GPI-anchored proteins"/>
            <pathway-xref db="Reactome" id="R-HSA-5635838" name="Activation of SMO"/>
            <pathway-xref db="Reactome" id="R-MMU-5635838" name="Activation of SMO"/>
            <pathway-xref db="Reactome" id="R-CFA-6785807" name="Interleukin-4 and Interleukin-13 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-447043" name="Neurofascin interactions"/>
            <pathway-xref db="Reactome" id="R-CEL-6809371" name="Formation of the cornified envelope"/>
            <pathway-xref db="Reactome" id="R-MMU-354192" name="Integrin signaling"/>
            <pathway-xref db="Reactome" id="R-CEL-9013149" name="RAC1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DRE-3928662" name="EPHB-mediated forward signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-6802952" name="Signaling by BRAF and RAF fusions"/>
            <pathway-xref db="Reactome" id="R-MMU-373753" name="Nephrin family interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-9020558" name="Interleukin-2 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-3928664" name="Ephrin signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-5173105" name="O-linked glycosylation"/>
            <pathway-xref db="Reactome" id="R-HSA-9696270" name="RND2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-193648" name="NRAGE signals death through JNK"/>
            <pathway-xref db="Reactome" id="R-CEL-3928663" name="EPHA-mediated growth cone collapse"/>
            <pathway-xref db="Reactome" id="R-HSA-110056" name="MAPK3 (ERK1) activation"/>
            <pathway-xref db="Reactome" id="R-HSA-9696264" name="RND3 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-9696273" name="RND1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-373760" name="L1CAM interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-8951664" name="Neddylation"/>
            <pathway-xref db="Reactome" id="R-MMU-372708" name="p130Cas linkage to MAPK signaling for integrins"/>
            <pathway-xref db="Reactome" id="R-MMU-3928663" name="EPHA-mediated growth cone collapse"/>
            <pathway-xref db="Reactome" id="R-RNO-6785807" name="Interleukin-4 and Interleukin-13 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9027284" name="Erythropoietin activates RAS"/>
            <pathway-xref db="Reactome" id="R-MMU-5632681" name="Ligand-receptor interactions"/>
            <pathway-xref db="Reactome" id="R-RNO-3928662" name="EPHB-mediated forward signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-5694530" name="Cargo concentration in the ER"/>
            <pathway-xref db="MetaCyc" id="PWY-7979" name="protein O-mannosylation III (mammals, core M3)"/>
            <pathway-xref db="Reactome" id="R-HSA-446107" name="Type I hemidesmosome assembly"/>
            <pathway-xref db="Reactome" id="R-HSA-1266695" name="Interleukin-7 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-74713" name="IRS activation"/>
            <pathway-xref db="MetaCyc" id="PWY-6627" name="salinosporamide A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-9027284" name="Erythropoietin activates RAS"/>
            <pathway-xref db="Reactome" id="R-HSA-9013149" name="RAC1 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-6720" name="toyocamycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-HSA-9013423" name="RAC3 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-CEL-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-MMU-9020558" name="Interleukin-2 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-428542" name="Regulation of commissural axon pathfinding by SLIT and ROBO"/>
            <pathway-xref db="Reactome" id="R-HSA-9013420" name="RHOU GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-449836" name="Other interleukin signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-140834" name="Extrinsic Pathway of Fibrin Clot Formation"/>
            <pathway-xref db="Reactome" id="R-HSA-212676" name="Dopamine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-416476" name="G alpha (q) signalling events"/>
            <pathway-xref db="Reactome" id="R-HSA-3928663" name="EPHA-mediated growth cone collapse"/>
            <pathway-xref db="Reactome" id="R-RNO-8874081" name="MET activates PTK2 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-RNO-3000178" name="ECM proteoglycans"/>
            <pathway-xref db="Reactome" id="R-RNO-373752" name="Netrin-1 signaling"/>
            <pathway-xref db="Reactome" id="R-DRE-3928664" name="Ephrin signaling"/>
            <pathway-xref db="Reactome" id="R-CEL-9013424" name="RHOV GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-9013423" name="RAC3 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-381426" name="Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"/>
            <pathway-xref db="Reactome" id="R-DME-5689603" name="UCH proteinases"/>
            <pathway-xref db="Reactome" id="R-HSA-5632681" name="Ligand-receptor interactions"/>
            <pathway-xref db="Reactome" id="R-MMU-9013420" name="RHOU GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-9013149" name="RAC1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-390522" name="Striated Muscle Contraction"/>
          </entry>
          <signature-library-release library="SUPERFAMILY" version="1.75"/>
        </signature>
        <model-ac>0050505</model-ac>
        <locations>
          <superfamilyhmmer3-location hmm-length="123" start="131" end="215">
            <location-fragments>
              <superfamilyhmmer3-location-fragment start="131" end="215" dc-status="CONTINUOUS"/>
            </location-fragments>
          </superfamilyhmmer3-location>
        </locations>
      </superfamilyhmmer3-match>
    </matches>
  </protein>
  <protein>
    <sequence md5="51cda0d9ec9d9ebb5ab3627ae5c5e0e9">MNINKYENEIRSPNDVFNSPDKADNLQNLNDTDYKDENMNNSQNGKNIFLLENIFENPIFKEQENDLQSAKAIQINSQRRQTISTSSDYNIFKSELNNMDNFNEFEETDDSLTNKDPVTDPLFISDCEEKNVDTSLVNSKSQSIKQEKSKYLHDKQISNVNNPFKKSTCKLNKKEKHLLKELKNVEEEEELPLPFINKLCSLCIKLIHKVPPQHKIENTGSHAPTRQEKKLFERYGPLRKGLYTPAEDKVITKNWETFCQLHDWNTKMVTPFLKWRHNEKYYISSVKERQKFVQFLANGLPWRTLHSVYARFKVIYCKKITYARYTLEEDNKILMYIRNEEFNKRNTKYIELAKLLKRTRRSIIKRYQYLKKIETDSEKEPSNIIWTLSLIKKFIKTLLNVTLSEDIRELKNAIIPKSVWQKMEEQLNIDENILKSFWQHQLHLQLFSPNPVYLNDIKIQLIEYIYEKGISNTREIVWPNVAKHLDGTTAVFLCKTFFYLVQECNINDMENFADIVEYLYHIKIPEIKEALTDKFLPRIVHKKGKIYLLNAEDSNDTLTTNSDN</sequence>
    <xref id="XP_029177188.1" name="XP_029177188.1 uncharacterized protein LOC114945240 isoform X2 [Nylanderia fulva]"/>
    <matches>
      <coils-match>
        <signature ac="Coil" name="Coil">
          <signature-library-release library="COILS" version="2.2.1"/>
        </signature>
        <model-ac>Coil</model-ac>
        <locations>
          <coils-location start="171" end="191">
            <location-fragments>
              <coils-location-fragment start="171" end="191" dc-status="CONTINUOUS"/>
            </location-fragments>
          </coils-location>
        </locations>
      </coils-match>
      <panther-match evalue="9.9E-25" familyName="CYCLIN-D-BINDING MYB-LIKE TRANSCRIPTION FACTOR 1" score="99.1">
        <signature ac="PTHR46380" name="CYCLIN-D-BINDING MYB-LIKE TRANSCRIPTION FACTOR 1">
          <signature-library-release library="PANTHER" version="15.0"/>
        </signature>
        <model-ac>PTHR46380</model-ac>
        <locations>
          <panther-location env-start="7" env-end="527" hmm-start="119" hmm-end="505" hmm-length="573" hmm-bounds="INCOMPLETE" start="61" end="487">
            <location-fragments>
              <panther-location-fragment start="61" end="487" dc-status="CONTINUOUS"/>
            </location-fragments>
          </panther-location>
        </locations>
      </panther-match>
    </matches>
  </protein>
  <protein>
    <sequence md5="33882bf4dabe18fad7dce8cade7a558c">MADHDNIYDDEELVSANPIKGIGVGILIALLVIVAVLALIVTSVALLTPPDDGPRVRGSRLRLSEVLSGEYXSLLFNGSWASDCHICYRDTWGGISLLDASDANIVLHSLMPNETFRRLNPVKFSLSPDHRYLLLAXNVKKLFRYSYLAQYVIYDVKSRECTVLTPHPEKDVHPYLLLAQWTPSGHGLVMVQDYDIYYMTAPMSDTGYRVTNTAVPGILSNGVPDWLYEEEILHSGEAIWMSPDGHMMLYASFNDSLVEEMHISWFGEGNKALYPDIRSLRYPKPGTPNPLVRLYVADLADPKNIRTKVVKPPSIIEHMDHYFSTASWVSQTEVCITWLTRAQNLSLVTICKSPMWHCQVRIQRITSEDRGWVDTPPEVPVFSANASSYVAISPVKDGPAGYYKHIIWANVLRKQIVPLTHGKFEVVKILVWDQVNNTIYFIGIPSMRPGQRHLYRVSSTLPQEGTPLPPAICLTCTVSSDVMNNDESEHRTSSSNAHQNGQANSNEWHQDHYESQTDNKENRQAKDTSKKNKSKNKNTSKILNSRLYW</sequence>
    <xref id="XP_029177717.1" name="XP_029177717.1 LOW QUALITY PROTEIN: inactive dipeptidyl peptidase 10-like [Nylanderia fulva]"/>
    <matches>
      <hmmer3-match evalue="5.1E-127" score="426.1">
        <signature ac="G3DSA:2.140.10.30" name="">
          <signature-library-release library="GENE3D" version="4.3.0"/>
        </signature>
        <model-ac>1z68A01</model-ac>
        <locations>
          <hmmer3-location env-end="536" env-start="59" post-processed="true" score="425.8" evalue="6.4E-127" hmm-start="4" hmm-end="409" hmm-length="464" hmm-bounds="COMPLETE" start="59" end="536">
            <location-fragments>
              <hmmer3-location-fragment start="59" end="536" dc-status="CONTINUOUS"/>
            </location-fragments>
          </hmmer3-location>
        </locations>
      </hmmer3-match>
      <hmmer3-match evalue="2.4E-79" score="266.7">
        <signature ac="PF00930" desc="Dipeptidyl peptidase IV (DPP IV) N-terminal region" name="DPPIV_N">
          <entry ac="IPR002469" desc="Dipeptidylpeptidase IV, N-terminal domain" name="Peptidase_S9B_N" type="DOMAIN">
            <go-xref category="BIOLOGICAL_PROCESS" db="GO" id="GO:0006508" name="proteolysis"/>
            <pathway-xref db="Reactome" id="R-HSA-400511" name="Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)"/>
            <pathway-xref db="Reactome" id="R-RNO-400511" name="Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)"/>
            <pathway-xref db="Reactome" id="R-MMU-381771" name="Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)"/>
            <pathway-xref db="Reactome" id="R-RNO-381771" name="Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)"/>
            <pathway-xref db="Reactome" id="R-HSA-381771" name="Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)"/>
            <pathway-xref db="Reactome" id="R-MMU-400511" name="Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)"/>
            <pathway-xref db="MetaCyc" id="PWY-7884" name="lipoprotein posttranslational modification"/>
          </entry>
          <signature-library-release library="PFAM" version="34.0"/>
        </signature>
        <model-ac>PF00930</model-ac>
        <locations>
          <hmmer3-location env-end="490" env-start="127" post-processed="true" score="266.3" evalue="3.0E-79" hmm-start="1" hmm-end="325" hmm-length="355" hmm-bounds="N_TERMINAL_COMPLETE" start="127" end="469">
            <location-fragments>
              <hmmer3-location-fragment start="127" end="469" dc-status="CONTINUOUS"/>
            </location-fragments>
          </hmmer3-location>
        </locations>
      </hmmer3-match>
      <mobidblite-match>
        <signature ac="mobidb-lite" desc="consensus disorder prediction" name="disorder_prediction">
          <signature-library-release library="MOBIDB_LITE" version="2.0"/>
        </signature>
        <model-ac>mobidb-lite</model-ac>
        <locations>
          <mobidblite-location sequence-feature="Polyampholyte" start="511" end="534">
            <location-fragments>
              <mobidblite-location-fragment start="511" end="534" dc-status="CONTINUOUS"/>
            </location-fragments>
          </mobidblite-location>
        </locations>
      </mobidblite-match>
      <mobidblite-match>
        <signature ac="mobidb-lite" desc="consensus disorder prediction" name="disorder_prediction">
          <signature-library-release library="MOBIDB_LITE" version="2.0"/>
        </signature>
        <model-ac>mobidb-lite</model-ac>
        <locations>
          <mobidblite-location sequence-feature="Polar" start="494" end="510">
            <location-fragments>
              <mobidblite-location-fragment start="494" end="510" dc-status="CONTINUOUS"/>
            </location-fragments>
          </mobidblite-location>
        </locations>
      </mobidblite-match>
      <mobidblite-match>
        <signature ac="mobidb-lite" desc="consensus disorder prediction" name="disorder_prediction">
          <signature-library-release library="MOBIDB_LITE" version="2.0"/>
        </signature>
        <model-ac>mobidb-lite</model-ac>
        <locations>
          <mobidblite-location sequence-feature="" start="484" end="544">
            <location-fragments>
              <mobidblite-location-fragment start="484" end="544" dc-status="CONTINUOUS"/>
            </location-fragments>
          </mobidblite-location>
        </locations>
      </mobidblite-match>
      <panther-match evalue="1.2E-113" familyName="INACTIVE DIPEPTIDYL PEPTIDASE 10-LIKE PROTEIN" score="392.5">
        <signature ac="PTHR11731:SF135" name="INACTIVE DIPEPTIDYL PEPTIDASE 10-LIKE PROTEIN">
          <signature-library-release library="PANTHER" version="15.0"/>
        </signature>
        <model-ac>PTHR11731:SF135</model-ac>
        <locations>
          <panther-location env-start="3" env-end="514" hmm-start="18" hmm-end="509" hmm-length="866" hmm-bounds="INCOMPLETE" start="9" end="485">
            <location-fragments>
              <panther-location-fragment start="9" end="485" dc-status="CONTINUOUS"/>
            </location-fragments>
          </panther-location>
        </locations>
      </panther-match>
      <panther-match evalue="1.2E-113" familyName="INACTIVE DIPEPTIDYL PEPTIDASE 10-LIKE PROTEIN" score="392.5">
        <signature ac="PTHR11731" name="PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED">
          <signature-library-release library="PANTHER" version="15.0"/>
        </signature>
        <model-ac>PTHR11731</model-ac>
        <locations>
          <panther-location env-start="3" env-end="514" hmm-start="18" hmm-end="509" hmm-length="866" hmm-bounds="INCOMPLETE" start="9" end="485">
            <location-fragments>
              <panther-location-fragment start="9" end="485" dc-status="CONTINUOUS"/>
            </location-fragments>
          </panther-location>
        </locations>
      </panther-match>
      <superfamilyhmmer3-match evalue="1.96E-43">
        <signature ac="SSF82171" name="DPP6 N-terminal domain-like">
          <signature-library-release library="SUPERFAMILY" version="1.75"/>
        </signature>
        <model-ac>0050946</model-ac>
        <locations>
          <superfamilyhmmer3-location hmm-length="465" start="61" end="477">
            <location-fragments>
              <superfamilyhmmer3-location-fragment start="61" end="477" dc-status="CONTINUOUS"/>
            </location-fragments>
          </superfamilyhmmer3-location>
        </locations>
      </superfamilyhmmer3-match>
    </matches>
  </protein>
  <protein>
    <sequence md5="5ef93401838b804f622cc43d5fb459a0">MFLQRFYRVMNYRILQRILHKNIYAVYKGGNGMQAVRKFWVTSPFITMGMWGFIKSKDESETQITSKEVLLAKVDALFDQGDYKSIYNLLSNYKDSKDVDILWRLCRAIYKMSEMASDVESRKLIYEGYDLICIALDIQEDHYAVHKWMSIFLNSKGTLEGTKAHIKELYNIKKHLLRASELKSTDATILYMLGCWCYEISNLAWYQRKIASIIFEEPPTSSFEEALMYHEKAEKVDPNFYSHNLLMLGKTYLKLNRKEDAIKYLKKAAEFSAENDDDQKAKQEAQKILNSI</sequence>
    <xref id="XP_029177203.1" name="XP_029177203.1 regulator of microtubule dynamics protein 1-like [Nylanderia fulva]"/>
    <xref id="XP_029177200.1" name="XP_029177200.1 regulator of microtubule dynamics protein 1-like [Nylanderia fulva]"/>
    <xref id="XP_029177201.1" name="XP_029177201.1 regulator of microtubule dynamics protein 1-like [Nylanderia fulva]"/>
    <xref id="XP_029177202.1" name="XP_029177202.1 regulator of microtubule dynamics protein 1-like [Nylanderia fulva]"/>
    <matches>
      <hmmer3-match evalue="1.1E-13" score="53.2">
        <signature ac="G3DSA:1.25.40.10" name="Tetratricopeptide repeat domain">
          <entry ac="IPR011990" desc="Tetratricopeptide-like helical domain superfamily" name="TPR-like_helical_dom_sf" type="HOMOLOGOUS_SUPERFAMILY">
            <go-xref category="MOLECULAR_FUNCTION" db="GO" id="GO:0005515" name="protein binding"/>
            <pathway-xref db="MetaCyc" id="PWY-8238" name="24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)"/>
            <pathway-xref db="Reactome" id="R-HSA-5358346" name="Hedgehog ligand biogenesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9610379" name="HCMV Late Events"/>
            <pathway-xref db="Reactome" id="R-CEL-5099900" name="WNT5A-dependent internalization of FZD4"/>
            <pathway-xref db="Reactome" id="R-HSA-4615885" name="SUMOylation of DNA replication proteins"/>
            <pathway-xref db="MetaCyc" id="PWY-7325" name="salvigenin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-6791226" name="Major pathway of rRNA processing in the nucleolus and cytosol"/>
            <pathway-xref db="MetaCyc" id="PWY-8035" name="streptovaricin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SCE-3214842" name="HDMs demethylate histones"/>
            <pathway-xref db="MetaCyc" id="PWY-7629" name="yatein biosynthesis II"/>
            <pathway-xref db="MetaCyc" id="PWY-6973" name="dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-163282" name="Mitochondrial transcription initiation"/>
            <pathway-xref db="Reactome" id="R-DME-9639288" name="Amino acids regulate mTORC1"/>
            <pathway-xref db="Reactome" id="R-CEL-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-MMU-6811434" name="COPI-dependent Golgi-to-ER retrograde traffic"/>
            <pathway-xref db="Reactome" id="R-SCE-9696273" name="RND1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-6791226" name="Major pathway of rRNA processing in the nucleolus and cytosol"/>
            <pathway-xref db="Reactome" id="R-MMU-5358346" name="Hedgehog ligand biogenesis"/>
            <pathway-xref db="Reactome" id="R-DRE-5620924" name="Intraflagellar transport"/>
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            <pathway-xref db="Reactome" id="R-DRE-350562" name="Regulation of ornithine decarboxylase (ODC)"/>
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            <pathway-xref db="MetaCyc" id="PWY-5797" name="indole-3-acetate inactivation VI"/>
            <pathway-xref db="Reactome" id="R-MMU-72649" name="Translation initiation complex formation"/>
            <pathway-xref db="MetaCyc" id="PWY-7285" name="methylwyosine biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-SCE-75955" name="RNA Polymerase II Transcription Elongation"/>
            <pathway-xref db="Reactome" id="R-HSA-1236978" name="Cross-presentation of soluble exogenous antigens (endosomes)"/>
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            <pathway-xref db="MetaCyc" id="PWY-8076" name="8-O-methylated benzoxazinoid glucoside biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-4202" name="arsenic detoxification (mammals)"/>
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            <pathway-xref db="MetaCyc" id="PWY-5287" name="sanguinarine and macarpine biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-7742" name="phenolphthiocerol biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-166208" name="mTORC1-mediated signalling"/>
            <pathway-xref db="Reactome" id="R-HSA-9609690" name="HCMV Early Events"/>
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            <pathway-xref db="Reactome" id="R-HSA-170822" name="Regulation of Glucokinase by Glucokinase Regulatory Protein"/>
            <pathway-xref db="MetaCyc" id="PWY-7058" name="esculetin modification"/>
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            <pathway-xref db="Reactome" id="R-DDI-9609523" name="Insertion of tail-anchored proteins into the endoplasmic reticulum membrane"/>
            <pathway-xref db="MetaCyc" id="PWY-8172" name="10-methylstearate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-674695" name="RNA Polymerase II Pre-transcription Events"/>
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            <pathway-xref db="Reactome" id="R-MMU-3214842" name="HDMs demethylate histones"/>
            <pathway-xref db="Reactome" id="R-RNO-6798695" name="Neutrophil degranulation"/>
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            <pathway-xref db="Reactome" id="R-MMU-2559582" name="Senescence-Associated Secretory Phenotype (SASP)"/>
            <pathway-xref db="MetaCyc" id="PWY-7689" name="8-O-methylfusarubin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-9696273" name="RND1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-8951664" name="Neddylation"/>
            <pathway-xref db="MetaCyc" id="PWY-6462" name="peptidoglycan cross-bridge biosynthesis III (Enterococcus faecalis)"/>
            <pathway-xref db="Reactome" id="R-RNO-429947" name="Deadenylation of mRNA"/>
            <pathway-xref db="Reactome" id="R-DDI-9664873" name="Pexophagy"/>
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            <pathway-xref db="Reactome" id="R-HSA-4570464" name="SUMOylation of RNA binding proteins"/>
            <pathway-xref db="MetaCyc" id="PWY-4161" name="superpathway of benzoxazinoid glucosides biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-6783310" name="Fanconi Anemia Pathway"/>
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            <pathway-xref db="MetaCyc" id="PWY-7979" name="protein O-mannosylation III (mammals, core M3)"/>
            <pathway-xref db="Reactome" id="R-RNO-3214847" name="HATs acetylate histones"/>
            <pathway-xref db="Reactome" id="R-HSA-9646399" name="Aggrephagy"/>
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            <pathway-xref db="Reactome" id="R-MMU-380284" name="Loss of proteins required for interphase microtubule organization from the centrosome"/>
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            <pathway-xref db="Reactome" id="R-CFA-1799339" name="SRP-dependent cotranslational protein targeting to membrane"/>
            <pathway-xref db="Reactome" id="R-RNO-9013423" name="RAC3 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-6477" name="gibberellin inactivation II (methylation)"/>
            <pathway-xref db="Reactome" id="R-SPO-2559580" name="Oxidative Stress Induced Senescence"/>
            <pathway-xref db="MetaCyc" id="PWY-7072" name="hopanoid biosynthesis (bacteria)"/>
            <pathway-xref db="Reactome" id="R-HSA-180910" name="Vpr-mediated nuclear import of PICs"/>
            <pathway-xref db="MetaCyc" id="PWY-7815" name="poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)"/>
            <pathway-xref db="Reactome" id="R-MMU-174048" name="APC/C:Cdc20 mediated degradation of Cyclin B"/>
            <pathway-xref db="Reactome" id="R-RNO-8939211" name="ESR-mediated signaling"/>
            <pathway-xref db="Reactome" id="R-DDI-174178" name="APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1"/>
            <pathway-xref db="Reactome" id="R-SCE-6798695" name="Neutrophil degranulation"/>
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            <pathway-xref db="Reactome" id="R-RNO-9664873" name="Pexophagy"/>
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            <pathway-xref db="Reactome" id="R-MMU-174154" name="APC/C:Cdc20 mediated degradation of Securin"/>
            <pathway-xref db="Reactome" id="R-HSA-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-6339" name="syringate degradation"/>
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            <pathway-xref db="Reactome" id="R-MMU-3214847" name="HATs acetylate histones"/>
            <pathway-xref db="Reactome" id="R-HSA-72165" name="mRNA Splicing - Minor Pathway"/>
            <pathway-xref db="Reactome" id="R-MMU-1236973" name="Cross-presentation of particulate exogenous antigens (phagosomes)"/>
            <pathway-xref db="Reactome" id="R-RNO-174084" name="Autodegradation of Cdh1 by Cdh1:APC/C"/>
            <pathway-xref db="Reactome" id="R-MMU-8866654" name="E3 ubiquitin ligases ubiquitinate target proteins"/>
            <pathway-xref db="MetaCyc" id="PWY-7076" name="3,5-dimethoxytoluene biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SPO-76066" name="RNA Polymerase III Transcription Initiation From Type 2 Promoter"/>
            <pathway-xref db="MetaCyc" id="PWY-8210" name="pyrrolomycin biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-MMU-9013423" name="RAC3 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-7440" name="dTDP-beta-L-4-epi-vancosamine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DRE-5685938" name="HDR through Single Strand Annealing (SSA)"/>
            <pathway-xref db="Reactome" id="R-DDI-5668599" name="RHO GTPases Activate NADPH Oxidases"/>
            <pathway-xref db="Reactome" id="R-SCE-8856828" name="Clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-MMU-381426" name="Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"/>
            <pathway-xref db="Reactome" id="R-HSA-3371497" name="HSP90 chaperone cycle for steroid hormone receptors (SHR)"/>
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            <pathway-xref db="MetaCyc" id="PWY-5301" name="ajmaline and sarpagine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-5624138" name="Trafficking of myristoylated proteins to the cilium"/>
            <pathway-xref db="Reactome" id="R-SPO-76061" name="RNA Polymerase III Transcription Initiation From Type 1 Promoter"/>
            <pathway-xref db="Reactome" id="R-HSA-1169408" name="ISG15 antiviral mechanism"/>
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          </entry>
          <signature-library-release library="PROSITE_PROFILES" version="2021_01"/>
        </signature>
        <model-ac>PS50005</model-ac>
        <locations>
          <profilescan-location score="9.4994" start="242" end="275">
            <location-fragments>
              <profilescan-location-fragment start="242" end="275" dc-status="CONTINUOUS"/>
            </location-fragments>
            <alignment>SHNLLMLGKTYLKLNRKEDAIKYLKKAAEFSAEN</alignment>
          </profilescan-location>
        </locations>
      </profilescan-match>
      <superfamilyhmmer3-match evalue="1.23E-10">
        <signature ac="SSF48452" name="TPR-like">
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            <pathway-xref db="MetaCyc" id="PWY-7629" name="yatein biosynthesis II"/>
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            <pathway-xref db="Reactome" id="R-HSA-9673324" name="WNT5:FZD7-mediated leishmania damping"/>
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            <pathway-xref db="MetaCyc" id="PWY-7591" name="okenone biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-6036" name="cardenolide glucosides biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-7729" name="5,6-dimethylbenzimidazole biosynthesis II (anaerobic)"/>
            <pathway-xref db="Reactome" id="R-MMU-191859" name="snRNP Assembly"/>
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            <pathway-xref db="Reactome" id="R-RNO-9639288" name="Amino acids regulate mTORC1"/>
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            <pathway-xref db="MetaCyc" id="PWY-7669" name="equisetin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DRE-382556" name="ABC-family proteins mediated transport"/>
            <pathway-xref db="Reactome" id="R-MMU-5607761" name="Dectin-1 mediated noncanonical NF-kB signaling"/>
            <pathway-xref db="Reactome" id="R-GGA-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7691" name="10,13-epoxy-11-methyl-octadecadienoate biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-MMU-6782210" name="Gap-filling DNA repair synthesis and ligation in TC-NER"/>
            <pathway-xref db="MetaCyc" id="PWY-5209" name="methyl-coenzyme M oxidation to CO2"/>
            <pathway-xref db="Reactome" id="R-MMU-112382" name="Formation of RNA Pol II elongation complex"/>
            <pathway-xref db="MetaCyc" id="PWY-5846" name="colchicine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5313" name="superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)"/>
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            <pathway-xref db="Reactome" id="R-RNO-2132295" name="MHC class II antigen presentation"/>
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            <pathway-xref db="MetaCyc" id="PWY-5139" name="pelargonidin conjugates biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-MMU-844456" name="The NLRP3 inflammasome"/>
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            <pathway-xref db="Reactome" id="R-SPO-6811438" name="Intra-Golgi traffic"/>
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            <pathway-xref db="MetaCyc" id="PWY-5774" name="saponin biosynthesis IV"/>
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            <pathway-xref db="Reactome" id="R-MMU-9020702" name="Interleukin-1 signaling"/>
            <pathway-xref db="Reactome" id="R-CEL-9013420" name="RHOU GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-83" name="monolignol glucosides biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-3371568" name="Attenuation phase"/>
            <pathway-xref db="Reactome" id="R-HSA-6783310" name="Fanconi Anemia Pathway"/>
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            <pathway-xref db="Reactome" id="R-DDI-3214842" name="HDMs demethylate histones"/>
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            <pathway-xref db="Reactome" id="R-HSA-5619107" name="Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC)"/>
            <pathway-xref db="MetaCyc" id="PWY-7623" name="astaxanthin dirhamnoside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-9609523" name="Insertion of tail-anchored proteins into the endoplasmic reticulum membrane"/>
            <pathway-xref db="Reactome" id="R-HSA-5632684" name="Hedgehog 'on' state"/>
            <pathway-xref db="Reactome" id="R-RNO-1234176" name="Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha"/>
            <pathway-xref db="MetaCyc" id="PWY-5822" name="trichloroethene degradation"/>
            <pathway-xref db="Reactome" id="R-SCE-9603798" name="Class I peroxisomal membrane protein import"/>
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            <pathway-xref db="MetaCyc" id="PWY-2902" name="cytokinin-O-glucosides biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8036" name="chaxamycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-432720" name="Lysosome Vesicle Biogenesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7743" name="dimycocerosyl triglycosyl phenolphthiocerol biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-6976" name="dTDP-beta-L-mycarose biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DDI-69601" name="Ubiquitin Mediated Degradation of Phosphorylated Cdc25A"/>
            <pathway-xref db="Reactome" id="R-HSA-196025" name="Formation of annular gap junctions"/>
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            <pathway-xref db="Reactome" id="R-RNO-9033241" name="Peroxisomal protein import"/>
            <pathway-xref db="MetaCyc" id="PWY-7160" name="polymethylated myricetin biosynthesis (tomato)"/>
            <pathway-xref db="Reactome" id="R-MMU-6804115" name="TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"/>
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            <pathway-xref db="Reactome" id="R-CEL-3214841" name="PKMTs methylate histone lysines"/>
            <pathway-xref db="Reactome" id="R-RNO-204005" name="COPII-mediated vesicle transport"/>
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            <pathway-xref db="Reactome" id="R-HSA-68949" name="Orc1 removal from chromatin"/>
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            <pathway-xref db="Reactome" id="R-SCE-75815" name="Ubiquitin-dependent degradation of Cyclin D"/>
            <pathway-xref db="MetaCyc" id="PWY-5301" name="ajmaline and sarpagine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SPO-204005" name="COPII-mediated vesicle transport"/>
            <pathway-xref db="Reactome" id="R-SPO-76061" name="RNA Polymerase III Transcription Initiation From Type 1 Promoter"/>
            <pathway-xref db="Reactome" id="R-MMU-75815" name="Ubiquitin-dependent degradation of Cyclin D"/>
            <pathway-xref db="Reactome" id="R-RNO-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-DDI-2559580" name="Oxidative Stress Induced Senescence"/>
            <pathway-xref db="Reactome" id="R-MMU-9013420" name="RHOU GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-9013149" name="RAC1 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-5321" name="quercetin glycoside biosynthesis (Arabidopsis)"/>
            <pathway-xref db="Reactome" id="R-HSA-180585" name="Vif-mediated degradation of APOBEC3G"/>
            <pathway-xref db="Reactome" id="R-GGA-8863795" name="Downregulation of ERBB2 signaling"/>
            <pathway-xref db="Reactome" id="R-DDI-6791226" name="Major pathway of rRNA processing in the nucleolus and cytosol"/>
            <pathway-xref db="Reactome" id="R-MMU-72165" name="mRNA Splicing - Minor Pathway"/>
            <pathway-xref db="Reactome" id="R-MMU-187577" name="SCF(Skp2)-mediated degradation of p27/p21"/>
            <pathway-xref db="MetaCyc" id="PWY-8235" name="Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-380972" name="Energy dependent regulation of mTOR by LKB1-AMPK"/>
            <pathway-xref db="Reactome" id="R-GGA-6804115" name="TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"/>
          </entry>
          <signature-library-release library="SUPERFAMILY" version="1.75"/>
        </signature>
        <model-ac>0051642</model-ac>
        <locations>
          <superfamilyhmmer3-location hmm-length="145" start="128" end="267">
            <location-fragments>
              <superfamilyhmmer3-location-fragment start="128" end="267" dc-status="CONTINUOUS"/>
            </location-fragments>
          </superfamilyhmmer3-location>
        </locations>
      </superfamilyhmmer3-match>
    </matches>
  </protein>
  <protein>
    <sequence md5="9d28b3b089be8b868337d311b95b4c71">MLLLQTQSSFGCSSFVELLSGPYTDPADAGSLPEELDPFPELQLGNPQGVSSVDESAQSHQSVHHQQPSQPPPPPPPLPEDIQADSLSPTPLPSFQETYTVQRYTRQELQGLGIKMDDECYDTPVYPCTATHYPTDFPVSYHEHQQQQPQQQHSHHHPPHHQQQAPHHHQSYFPAESAPTPATAVVPPSNHRQDPSYGVAVTVPMVYGAPSAIANVATPVAPNDLCPNVDTSVVIGTSRSRRASLPTQRSESASSGSTESPKPRGSGTASSTVSSPSPGSGTSGERAPPSPSQLCAVCGDTAACQHYGVRTCEGCKGFFKRTVQKGSKYVCLAEKACPVDKRRRNRCQFCRFQKCLMVGMVKEVVRTDSLKGRRGRLPSKPKSPQESPPSPPVSLITALVRAHLDTTPDKASLDYSQYRQPRPGDPPMTEAEKIQQFYNLLTTSIDVIRNFADKIPGFTDLVREDQELLFQSASLELFVLRLAYRTNPDDTKLVFCNGVVLALEQCQRSFGDWLHSILEFCKALHFLEVDISAFACLCALTLVTERYGLKEPQRMEQLQMKIVSSLRDHVTYNAEAQRKSQYLSYLLSKIPELRSLSVQGLQRIFYLKLEDLVPAPPLIETMFVGSLPF</sequence>
    <xref id="XP_029176734.1" name="XP_029176734.1 probable nuclear hormone receptor HR38 isoform X2 [Nylanderia fulva]"/>
    <matches>
      <fingerprints-match evalue="9.4E-17" graphscan="IIII">
        <signature ac="PR00047" desc="C4-type steroid receptor zinc finger signature" name="STROIDFINGER">
          <entry ac="IPR001628" desc="Zinc finger, nuclear hormone receptor-type" name="Znf_hrmn_rcpt" type="DOMAIN">
            <go-xref category="MOLECULAR_FUNCTION" db="GO" id="GO:0043565" name="sequence-specific DNA binding"/>
            <go-xref category="MOLECULAR_FUNCTION" db="GO" id="GO:0008270" name="zinc ion binding"/>
            <go-xref category="BIOLOGICAL_PROCESS" db="GO" id="GO:0006355" name="regulation of transcription, DNA-templated"/>
            <go-xref category="MOLECULAR_FUNCTION" db="GO" id="GO:0003700" name="DNA-binding transcription factor activity"/>
            <pathway-xref db="MetaCyc" id="PWY-8238" name="24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)"/>
            <pathway-xref db="Reactome" id="R-CEL-400206" name="Regulation of lipid metabolism by PPARalpha"/>
            <pathway-xref db="MetaCyc" id="PWY-7735" name="echinomycin and triostin A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-8939211" name="ESR-mediated signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-2892247" name="POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation"/>
            <pathway-xref db="Reactome" id="R-CFA-198693" name="AKT phosphorylates targets in the nucleus"/>
            <pathway-xref db="Reactome" id="R-MMU-8866910" name="TFAP2 (AP-2) family regulates transcription of growth factors and their receptors"/>
            <pathway-xref db="Reactome" id="R-DRE-193807" name="Synthesis of bile acids and bile salts via 27-hydroxycholesterol"/>
            <pathway-xref db="MetaCyc" id="PWY-7325" name="salvigenin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7752" name="gadusol biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-9623433" name="NR1H2 &amp; NR1H3 regulate gene expression to control bile acid homeostasis"/>
            <pathway-xref db="Reactome" id="R-CEL-5362517" name="Signaling by Retinoic Acid"/>
            <pathway-xref db="MetaCyc" id="PWY-8035" name="streptovaricin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7150" name="polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)"/>
            <pathway-xref db="MetaCyc" id="PWY-7751" name="shinorine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7629" name="yatein biosynthesis II"/>
            <pathway-xref db="MetaCyc" id="PWY-6973" name="dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-4090294" name="SUMOylation of intracellular receptors"/>
            <pathway-xref db="MetaCyc" id="PWY-8104" name="yangonin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6978" name="plastoquinol-9 biosynthesis II"/>
            <pathway-xref db="Reactome" id="R-HSA-4090294" name="SUMOylation of intracellular receptors"/>
            <pathway-xref db="Reactome" id="R-HSA-196791" name="Vitamin D (calciferol) metabolism"/>
            <pathway-xref db="MetaCyc" id="PWY-7151" name="polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)"/>
            <pathway-xref db="MetaCyc" id="PWY-8100" name="crotonosine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-8936459" name="RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"/>
            <pathway-xref db="Reactome" id="R-CEL-381340" name="Transcriptional regulation of white adipocyte differentiation"/>
            <pathway-xref db="Reactome" id="R-HSA-193807" name="Synthesis of bile acids and bile salts via 27-hydroxycholesterol"/>
            <pathway-xref db="MetaCyc" id="PWY-8047" name="bryostatin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-2151201" name="Transcriptional activation of mitochondrial biogenesis"/>
            <pathway-xref db="Reactome" id="R-DME-4090294" name="SUMOylation of intracellular receptors"/>
            <pathway-xref db="MetaCyc" id="PWY-7631" name="arctigenin and isoarctigenin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-211976" name="Endogenous sterols"/>
            <pathway-xref db="Reactome" id="R-RNO-159418" name="Recycling of bile acids and salts"/>
            <pathway-xref db="Reactome" id="R-DME-198693" name="AKT phosphorylates targets in the nucleus"/>
            <pathway-xref db="Reactome" id="R-MMU-200425" name="Carnitine metabolism"/>
            <pathway-xref db="Reactome" id="R-HSA-8939211" name="ESR-mediated signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-204174" name="Regulation of pyruvate dehydrogenase (PDH) complex"/>
            <pathway-xref db="Reactome" id="R-SSC-383280" name="Nuclear Receptor transcription pathway"/>
            <pathway-xref db="Reactome" id="R-SSC-381340" name="Transcriptional regulation of white adipocyte differentiation"/>
            <pathway-xref db="Reactome" id="R-DRE-9018519" name="Estrogen-dependent gene expression"/>
            <pathway-xref db="MetaCyc" id="PWY-7163" name="polymethylated kaempferol biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SSC-196791" name="Vitamin D (calciferol) metabolism"/>
            <pathway-xref db="MetaCyc" id="PWY-8212" name="Escherichia coli serotype O:8 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-400253" name="Circadian Clock"/>
            <pathway-xref db="Reactome" id="R-DRE-196791" name="Vitamin D (calciferol) metabolism"/>
            <pathway-xref db="MetaCyc" id="PWY-8095" name="5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)"/>
            <pathway-xref db="MetaCyc" id="PWY-6045" name="methylthiopropanonate degradation II (demethylation)"/>
            <pathway-xref db="MetaCyc" id="PWY-7135" name="emetine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7569" name="arginomycin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8077" name="ginkgotoxin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7498" name="phenylpropanoids methylation (ice plant)"/>
            <pathway-xref db="Reactome" id="R-MMU-383280" name="Nuclear Receptor transcription pathway"/>
            <pathway-xref db="Reactome" id="R-HSA-9031528" name="NR1H2 &amp; NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose"/>
            <pathway-xref db="Reactome" id="R-HSA-8936459" name="RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"/>
            <pathway-xref db="Reactome" id="R-MMU-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-DRE-9009391" name="Extra-nuclear estrogen signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-198693" name="AKT phosphorylates targets in the nucleus"/>
            <pathway-xref db="MetaCyc" id="PWY-7298" name="nevadensin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9616222" name="Transcriptional regulation of granulopoiesis"/>
            <pathway-xref db="Reactome" id="R-HSA-1368108" name="BMAL1:CLOCK,NPAS2 activates circadian gene expression"/>
            <pathway-xref db="Reactome" id="R-HSA-8940973" name="RUNX2 regulates osteoblast differentiation"/>
            <pathway-xref db="Reactome" id="R-HSA-9022707" name="MECP2 regulates transcription factors"/>
            <pathway-xref db="Reactome" id="R-MMU-193807" name="Synthesis of bile acids and bile salts via 27-hydroxycholesterol"/>
            <pathway-xref db="Reactome" id="R-RNO-9616222" name="Transcriptional regulation of granulopoiesis"/>
            <pathway-xref db="Reactome" id="R-HSA-5674400" name="Constitutive Signaling by AKT1 E17K in Cancer"/>
            <pathway-xref db="MetaCyc" id="PWY-5729" name="vestitol and sativan biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7301" name="dTDP-4-O-demethyl-beta-L-noviose biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8103" name="kavain biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-383280" name="Nuclear Receptor transcription pathway"/>
            <pathway-xref db="MetaCyc" id="PWY-5883" name="ephedrine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DRE-6811558" name="PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"/>
            <pathway-xref db="Reactome" id="R-DRE-5689896" name="Ovarian tumor domain proteases"/>
            <pathway-xref db="Reactome" id="R-CEL-159418" name="Recycling of bile acids and salts"/>
            <pathway-xref db="MetaCyc" id="PWY-7483" name="elloramycin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8036" name="chaxamycin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7717" name="3-hydroxy-4-methyl-anthranilate biosynthesis I"/>
            <pathway-xref db="Reactome" id="R-HSA-204174" name="Regulation of pyruvate dehydrogenase (PDH) complex"/>
            <pathway-xref db="MetaCyc" id="PWY-7743" name="dimycocerosyl triglycosyl phenolphthiocerol biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5987" name="sorgoleone biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-9009391" name="Extra-nuclear estrogen signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-6976" name="dTDP-beta-L-mycarose biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-5362517" name="Signaling by Retinoic Acid"/>
            <pathway-xref db="Reactome" id="R-CFA-9707564" name="Cytoprotection by HMOX1"/>
            <pathway-xref db="MetaCyc" id="PWY-7160" name="polymethylated myricetin biosynthesis (tomato)"/>
            <pathway-xref db="Reactome" id="R-MMU-8931987" name="RUNX1 regulates estrogen receptor mediated transcription"/>
            <pathway-xref db="MetaCyc" id="PWY-7655" name="dechlorogriseofulvin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7607" name="meleagrin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DRE-5362517" name="Signaling by Retinoic Acid"/>
            <pathway-xref db="Reactome" id="R-HSA-9009391" name="Extra-nuclear estrogen signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-7533" name="gliotoxin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7564" name="bacimethrin and bacimethrin pyrophosphate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8040" name="ansatrienin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8096" name="5-methoxybenzimidazole biosynthesis (anaerobic)"/>
            <pathway-xref db="Reactome" id="R-MMU-9616222" name="Transcriptional regulation of granulopoiesis"/>
            <pathway-xref db="Reactome" id="R-DME-9623433" name="NR1H2 &amp; NR1H3 regulate gene expression to control bile acid homeostasis"/>
            <pathway-xref db="MetaCyc" id="PWY-6581" name="spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7591" name="okenone biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DRE-200425" name="Carnitine metabolism"/>
            <pathway-xref db="Reactome" id="R-GGA-383280" name="Nuclear Receptor transcription pathway"/>
            <pathway-xref db="Reactome" id="R-MMU-1251985" name="Nuclear signaling by ERBB4"/>
            <pathway-xref db="Reactome" id="R-MMU-198693" name="AKT phosphorylates targets in the nucleus"/>
            <pathway-xref db="Reactome" id="R-GGA-4090294" name="SUMOylation of intracellular receptors"/>
            <pathway-xref db="Reactome" id="R-DRE-383280" name="Nuclear Receptor transcription pathway"/>
            <pathway-xref db="MetaCyc" id="PWY-5665" name="vanillin biosynthesis I"/>
            <pathway-xref db="MetaCyc" id="PWY-7025" name="gentamicin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9031525" name="NR1H2 &amp; NR1H3 regulate gene expression to limit cholesterol uptake"/>
            <pathway-xref db="Reactome" id="R-CEL-200425" name="Carnitine metabolism"/>
            <pathway-xref db="Reactome" id="R-HSA-1368071" name="NR1D1 (REV-ERBA) represses gene expression"/>
            <pathway-xref db="MetaCyc" id="PWY-6795" name="diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-5625886" name="Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3"/>
            <pathway-xref db="MetaCyc" id="PWY-7765" name="3-hydroxy-4-methyl-anthranilate biosynthesis II"/>
            <pathway-xref db="Reactome" id="R-HSA-8943724" name="Regulation of PTEN gene transcription"/>
            <pathway-xref db="Reactome" id="R-DRE-8931987" name="RUNX1 regulates estrogen receptor mediated transcription"/>
            <pathway-xref db="Reactome" id="R-MMU-5362517" name="Signaling by Retinoic Acid"/>
            <pathway-xref db="MetaCyc" id="PWY-7671" name="saframycin A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-400206" name="Regulation of lipid metabolism by PPARalpha"/>
            <pathway-xref db="MetaCyc" id="PWY-7155" name="7-dehydroporiferasterol biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DRE-9707564" name="Cytoprotection by HMOX1"/>
            <pathway-xref db="MetaCyc" id="PWY-5305" name="bixin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-193807" name="Synthesis of bile acids and bile salts via 27-hydroxycholesterol"/>
            <pathway-xref db="Reactome" id="R-HSA-5625886" name="Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3"/>
            <pathway-xref db="Reactome" id="R-HSA-1989781" name="PPARA activates gene expression"/>
            <pathway-xref db="MetaCyc" id="PWY-6153" name="autoinducer AI-2 biosynthesis I"/>
            <pathway-xref db="Reactome" id="R-BTA-8866427" name="VLDLR internalisation and degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-452723" name="Transcriptional regulation of pluripotent stem cells"/>
            <pathway-xref db="Reactome" id="R-DME-204174" name="Regulation of pyruvate dehydrogenase (PDH) complex"/>
            <pathway-xref db="Reactome" id="R-HSA-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="MetaCyc" id="PWY-7739" name="aucuparin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-383280" name="Nuclear Receptor transcription pathway"/>
            <pathway-xref db="Reactome" id="R-DRE-9029569" name="NR1H3 &amp; NR1H2 regulate gene expression linked to cholesterol transport and efflux"/>
            <pathway-xref db="Reactome" id="R-RNO-9009391" name="Extra-nuclear estrogen signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-5362517" name="Signaling by Retinoic Acid"/>
            <pathway-xref db="MetaCyc" id="PWY-5059" name="pinobanksin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-196791" name="Vitamin D (calciferol) metabolism"/>
            <pathway-xref db="Reactome" id="R-RNO-383280" name="Nuclear Receptor transcription pathway"/>
            <pathway-xref db="MetaCyc" id="PWY-7745" name="p-HBAD biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7653" name="griseofulvin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7614" name="methiin metabolism"/>
            <pathway-xref db="MetaCyc" id="PWY-5765" name="1,3,5-trimethoxybenzene biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-6811558" name="PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9707616" name="Heme signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-9029569" name="NR1H3 &amp; NR1H2 regulate gene expression linked to cholesterol transport and efflux"/>
            <pathway-xref db="Reactome" id="R-RNO-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-HSA-8939902" name="Regulation of RUNX2 expression and activity"/>
            <pathway-xref db="MetaCyc" id="PWY-7977" name="L-methionine biosynthesis IV"/>
            <pathway-xref db="Reactome" id="R-HSA-8866910" name="TFAP2 (AP-2) family regulates transcription of growth factors and their receptors"/>
            <pathway-xref db="Reactome" id="R-RNO-8866910" name="TFAP2 (AP-2) family regulates transcription of growth factors and their receptors"/>
            <pathway-xref db="MetaCyc" id="PWY-7673" name="fusarin C biosynthesis"/>
            <pathway-xref db="Reactome" id="R-BTA-8939211" name="ESR-mediated signaling"/>
            <pathway-xref db="Reactome" id="R-DRE-9616222" name="Transcriptional regulation of granulopoiesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6835" name="6-gingerol biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9690406" name="Transcriptional regulation of testis differentiation"/>
            <pathway-xref db="MetaCyc" id="PWY-6286" name="spheroidene and spheroidenone biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-210747" name="Regulation of gene expression in early pancreatic precursor cells"/>
            <pathway-xref db="MetaCyc" id="PWY-8031" name="epiberberine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-9707564" name="Cytoprotection by HMOX1"/>
            <pathway-xref db="Reactome" id="R-HSA-9615017" name="FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes"/>
            <pathway-xref db="Reactome" id="R-DRE-1257604" name="PIP3 activates AKT signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-6811558" name="PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-381340" name="Transcriptional regulation of white adipocyte differentiation"/>
            <pathway-xref db="MetaCyc" id="PWY-7570" name="blasticidin S biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-5617472" name="Activation of anterior HOX genes in hindbrain development during early embryogenesis"/>
            <pathway-xref db="MetaCyc" id="PWY-3542" name="choline biosynthesis II"/>
            <pathway-xref db="Reactome" id="R-DRE-1251985" name="Nuclear signaling by ERBB4"/>
            <pathway-xref db="MetaCyc" id="PWY-7695" name="aurofusarin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-1257604" name="PIP3 activates AKT signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-9623433" name="NR1H2 &amp; NR1H3 regulate gene expression to control bile acid homeostasis"/>
            <pathway-xref db="MetaCyc" id="PWY-6442" name="spermidine hydroxycinnamic acid conjugates biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-211976" name="Endogenous sterols"/>
            <pathway-xref db="MetaCyc" id="PWY-7826" name="Amaryllidacea alkaloids biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-5362517" name="Signaling by Retinoic Acid"/>
            <pathway-xref db="MetaCyc" id="PWY-7161" name="polymethylated quercetin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5975" name="furaneol and mesifurane biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-196791" name="Vitamin D (calciferol) metabolism"/>
            <pathway-xref db="MetaCyc" id="PWY-6739" name="pinitol biosynthesis II"/>
            <pathway-xref db="MetaCyc" id="PWY-7045" name="mithramycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-1257604" name="PIP3 activates AKT signaling"/>
            <pathway-xref db="Reactome" id="R-DME-400206" name="Regulation of lipid metabolism by PPARalpha"/>
            <pathway-xref db="MetaCyc" id="PWY-8122" name="mycofactocin biosynthesis"/>
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      <mobidblite-match>
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      <mobidblite-match>
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      <mobidblite-match>
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      <mobidblite-match>
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      <mobidblite-match>
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      <mobidblite-match>
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            <pathway-xref db="Reactome" id="R-RNO-383280" name="Nuclear Receptor transcription pathway"/>
            <pathway-xref db="MetaCyc" id="PWY-7745" name="p-HBAD biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-7614" name="methiin metabolism"/>
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            <pathway-xref db="Reactome" id="R-HSA-9707616" name="Heme signaling"/>
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            <pathway-xref db="Reactome" id="R-RNO-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-HSA-8939902" name="Regulation of RUNX2 expression and activity"/>
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            <pathway-xref db="MetaCyc" id="PWY-7826" name="Amaryllidacea alkaloids biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-7161" name="polymethylated quercetin biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-6739" name="pinitol biosynthesis II"/>
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            <pathway-xref db="Reactome" id="R-DME-400206" name="Regulation of lipid metabolism by PPARalpha"/>
            <pathway-xref db="MetaCyc" id="PWY-8122" name="mycofactocin biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-7517" name="brassicicene C biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-MMU-193368" name="Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol"/>
            <pathway-xref db="MetaCyc" id="PWY-5773" name="gossypol biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-CFA-400206" name="Regulation of lipid metabolism by PPARalpha"/>
            <pathway-xref db="Reactome" id="R-RNO-3371497" name="HSP90 chaperone cycle for steroid hormone receptors (SHR)"/>
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            <pathway-xref db="MetaCyc" id="PWY-8076" name="8-O-methylated benzoxazinoid glucoside biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-MMU-3371497" name="HSP90 chaperone cycle for steroid hormone receptors (SHR)"/>
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            <pathway-xref db="Reactome" id="R-HSA-9623433" name="NR1H2 &amp; NR1H3 regulate gene expression to control bile acid homeostasis"/>
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            <pathway-xref db="Reactome" id="R-HSA-9029558" name="NR1H2 &amp; NR1H3 regulate gene expression linked to lipogenesis"/>
            <pathway-xref db="Reactome" id="R-DME-9616222" name="Transcriptional regulation of granulopoiesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-7661" name="protein N-glycosylation (Haloferax volcanii)"/>
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            <pathway-xref db="MetaCyc" id="PWY-6682" name="dehydrophos biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-BTA-383280" name="Nuclear Receptor transcription pathway"/>
            <pathway-xref db="MetaCyc" id="PWY-7440" name="dTDP-beta-L-4-epi-vancosamine biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-DME-8939236" name="RUNX1 regulates transcription of genes involved in differentiation of HSCs"/>
            <pathway-xref db="Reactome" id="R-GGA-9616222" name="Transcriptional regulation of granulopoiesis"/>
            <pathway-xref db="Reactome" id="R-CFA-200425" name="Carnitine metabolism"/>
            <pathway-xref db="MetaCyc" id="PWY-5301" name="ajmaline and sarpagine biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-4202" name="arsenic detoxification (mammals)"/>
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            <pathway-xref db="Reactome" id="R-RNO-5689896" name="Ovarian tumor domain proteases"/>
            <pathway-xref db="Reactome" id="R-RNO-198693" name="AKT phosphorylates targets in the nucleus"/>
            <pathway-xref db="MetaCyc" id="PWY-5287" name="sanguinarine and macarpine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-6785807" name="Interleukin-4 and Interleukin-13 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-7608" name="neoxaline biosynthesis"/>
          </entry>
          <signature-library-release library="PROSITE_PATTERNS" version="2021_01"/>
        </signature>
        <model-ac>PS00031</model-ac>
        <locations>
          <patternscan-location level="STRONG" start="295" end="321">
            <location-fragments>
              <patternscan-location-fragment start="295" end="321" dc-status="CONTINUOUS"/>
            </location-fragments>
            <alignment>CavCgDtaacqHYgvrtCegCkgFFkR</alignment>
          </patternscan-location>
        </locations>
      </patternscan-match>
      <profilescan-match>
        <signature ac="PS51030" desc="Nuclear hormone receptors DNA-binding domain profile." name="NUCLEAR_REC_DBD_2">
          <entry ac="IPR001628" desc="Zinc finger, nuclear hormone receptor-type" name="Znf_hrmn_rcpt" type="DOMAIN">
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            <go-xref category="MOLECULAR_FUNCTION" db="GO" id="GO:0008270" name="zinc ion binding"/>
            <go-xref category="BIOLOGICAL_PROCESS" db="GO" id="GO:0006355" name="regulation of transcription, DNA-templated"/>
            <go-xref category="MOLECULAR_FUNCTION" db="GO" id="GO:0003700" name="DNA-binding transcription factor activity"/>
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            <pathway-xref db="Reactome" id="R-HSA-2892247" name="POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation"/>
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            <pathway-xref db="MetaCyc" id="PWY-7325" name="salvigenin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7752" name="gadusol biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-9623433" name="NR1H2 &amp; NR1H3 regulate gene expression to control bile acid homeostasis"/>
            <pathway-xref db="Reactome" id="R-CEL-5362517" name="Signaling by Retinoic Acid"/>
            <pathway-xref db="MetaCyc" id="PWY-8035" name="streptovaricin biosynthesis"/>
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        </signature>
        <model-ac>PS51843</model-ac>
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            </location-fragments>
            <alignment>PPVSLITALVRAHLDTTPDKASLDYSQYRQPrpgdPPMTEAEKIQQFYNLLTTSIDVIRNFADKIPGFTDLVREDQELLFQSASLELFVLRLAYRTNPD--DTKLVFCNGVVLALEQCQRS--FGDWLHSILEFCKALHFLEVDISAFACLCALTLVT--ERYGLKEPQRMEQLQMKIVSSLRDHVTYNAEAQRkSQYLSYLLSKIPELRSLSVQGLQRIFYLKLEDLVPAPPLIETMFVGS</alignment>
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                  <site-location residue="D" start="446" end="446"/>
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                  <site-location residue="Q" start="471" end="471"/>
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                <site-locations>
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            <pathway-xref db="Reactome" id="R-HSA-6811558" name="PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9707616" name="Heme signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-9029569" name="NR1H3 &amp; NR1H2 regulate gene expression linked to cholesterol transport and efflux"/>
            <pathway-xref db="Reactome" id="R-RNO-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-HSA-8939902" name="Regulation of RUNX2 expression and activity"/>
            <pathway-xref db="Reactome" id="R-HSA-8866910" name="TFAP2 (AP-2) family regulates transcription of growth factors and their receptors"/>
            <pathway-xref db="Reactome" id="R-RNO-8866910" name="TFAP2 (AP-2) family regulates transcription of growth factors and their receptors"/>
            <pathway-xref db="Reactome" id="R-BTA-8939211" name="ESR-mediated signaling"/>
            <pathway-xref db="Reactome" id="R-DRE-9616222" name="Transcriptional regulation of granulopoiesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9690406" name="Transcriptional regulation of testis differentiation"/>
            <pathway-xref db="Reactome" id="R-HSA-210747" name="Regulation of gene expression in early pancreatic precursor cells"/>
            <pathway-xref db="Reactome" id="R-MMU-9707564" name="Cytoprotection by HMOX1"/>
            <pathway-xref db="Reactome" id="R-HSA-9615017" name="FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes"/>
            <pathway-xref db="Reactome" id="R-DRE-1257604" name="PIP3 activates AKT signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-6811558" name="PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-381340" name="Transcriptional regulation of white adipocyte differentiation"/>
            <pathway-xref db="Reactome" id="R-HSA-5617472" name="Activation of anterior HOX genes in hindbrain development during early embryogenesis"/>
            <pathway-xref db="Reactome" id="R-DRE-1251985" name="Nuclear signaling by ERBB4"/>
            <pathway-xref db="Reactome" id="R-HSA-1257604" name="PIP3 activates AKT signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-9623433" name="NR1H2 &amp; NR1H3 regulate gene expression to control bile acid homeostasis"/>
            <pathway-xref db="Reactome" id="R-HSA-211976" name="Endogenous sterols"/>
            <pathway-xref db="Reactome" id="R-RNO-5362517" name="Signaling by Retinoic Acid"/>
            <pathway-xref db="Reactome" id="R-RNO-196791" name="Vitamin D (calciferol) metabolism"/>
            <pathway-xref db="Reactome" id="R-MMU-1257604" name="PIP3 activates AKT signaling"/>
            <pathway-xref db="Reactome" id="R-DME-400206" name="Regulation of lipid metabolism by PPARalpha"/>
            <pathway-xref db="Reactome" id="R-HSA-9018519" name="Estrogen-dependent gene expression"/>
            <pathway-xref db="Reactome" id="R-HSA-9029569" name="NR1H3 &amp; NR1H2 regulate gene expression linked to cholesterol transport and efflux"/>
            <pathway-xref db="Reactome" id="R-MMU-6811558" name="PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"/>
            <pathway-xref db="Reactome" id="R-DRE-4090294" name="SUMOylation of intracellular receptors"/>
            <pathway-xref db="Reactome" id="R-MMU-193368" name="Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol"/>
            <pathway-xref db="Reactome" id="R-HSA-159418" name="Recycling of bile acids and salts"/>
            <pathway-xref db="Reactome" id="R-RNO-8866427" name="VLDLR internalisation and degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-9632974" name="NR1H2 &amp; NR1H3 regulate gene expression linked to gluconeogenesis"/>
            <pathway-xref db="Reactome" id="R-CFA-400206" name="Regulation of lipid metabolism by PPARalpha"/>
            <pathway-xref db="Reactome" id="R-RNO-3371497" name="HSP90 chaperone cycle for steroid hormone receptors (SHR)"/>
            <pathway-xref db="Reactome" id="R-DRE-192105" name="Synthesis of bile acids and bile salts"/>
            <pathway-xref db="Reactome" id="R-MMU-5689896" name="Ovarian tumor domain proteases"/>
            <pathway-xref db="Reactome" id="R-MMU-3371497" name="HSP90 chaperone cycle for steroid hormone receptors (SHR)"/>
            <pathway-xref db="Reactome" id="R-XTR-383280" name="Nuclear Receptor transcription pathway"/>
            <pathway-xref db="Reactome" id="R-CEL-198693" name="AKT phosphorylates targets in the nucleus"/>
            <pathway-xref db="Reactome" id="R-MMU-9018519" name="Estrogen-dependent gene expression"/>
            <pathway-xref db="Reactome" id="R-HSA-9707564" name="Cytoprotection by HMOX1"/>
            <pathway-xref db="Reactome" id="R-DME-381340" name="Transcriptional regulation of white adipocyte differentiation"/>
            <pathway-xref db="Reactome" id="R-DRE-8939211" name="ESR-mediated signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-5625886" name="Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3"/>
            <pathway-xref db="Reactome" id="R-RNO-1257604" name="PIP3 activates AKT signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-211976" name="Endogenous sterols"/>
            <pathway-xref db="Reactome" id="R-RNO-8931987" name="RUNX1 regulates estrogen receptor mediated transcription"/>
            <pathway-xref db="Reactome" id="R-BTA-9623433" name="NR1H2 &amp; NR1H3 regulate gene expression to control bile acid homeostasis"/>
            <pathway-xref db="Reactome" id="R-HSA-9623433" name="NR1H2 &amp; NR1H3 regulate gene expression to control bile acid homeostasis"/>
            <pathway-xref db="Reactome" id="R-CEL-9616222" name="Transcriptional regulation of granulopoiesis"/>
            <pathway-xref db="Reactome" id="R-CEL-4090294" name="SUMOylation of intracellular receptors"/>
            <pathway-xref db="Reactome" id="R-RNO-9029569" name="NR1H3 &amp; NR1H2 regulate gene expression linked to cholesterol transport and efflux"/>
            <pathway-xref db="Reactome" id="R-DRE-159418" name="Recycling of bile acids and salts"/>
            <pathway-xref db="Reactome" id="R-CFA-5362517" name="Signaling by Retinoic Acid"/>
            <pathway-xref db="Reactome" id="R-HSA-8849473" name="PTK6 Expression"/>
            <pathway-xref db="Reactome" id="R-MMU-192105" name="Synthesis of bile acids and bile salts"/>
            <pathway-xref db="Reactome" id="R-RNO-9707564" name="Cytoprotection by HMOX1"/>
            <pathway-xref db="Reactome" id="R-MMU-9623433" name="NR1H2 &amp; NR1H3 regulate gene expression to control bile acid homeostasis"/>
            <pathway-xref db="Reactome" id="R-HSA-9029558" name="NR1H2 &amp; NR1H3 regulate gene expression linked to lipogenesis"/>
            <pathway-xref db="Reactome" id="R-DME-9616222" name="Transcriptional regulation of granulopoiesis"/>
            <pathway-xref db="Reactome" id="R-HSA-1368082" name="RORA activates gene expression"/>
            <pathway-xref db="Reactome" id="R-CEL-196791" name="Vitamin D (calciferol) metabolism"/>
            <pathway-xref db="Reactome" id="R-RNO-200425" name="Carnitine metabolism"/>
            <pathway-xref db="Reactome" id="R-HSA-381340" name="Transcriptional regulation of white adipocyte differentiation"/>
            <pathway-xref db="Reactome" id="R-DME-159418" name="Recycling of bile acids and salts"/>
            <pathway-xref db="Reactome" id="R-RNO-204174" name="Regulation of pyruvate dehydrogenase (PDH) complex"/>
            <pathway-xref db="Reactome" id="R-DME-9029569" name="NR1H3 &amp; NR1H2 regulate gene expression linked to cholesterol transport and efflux"/>
            <pathway-xref db="Reactome" id="R-CFA-383280" name="Nuclear Receptor transcription pathway"/>
            <pathway-xref db="Reactome" id="R-HSA-1251985" name="Nuclear signaling by ERBB4"/>
            <pathway-xref db="Reactome" id="R-DME-9707564" name="Cytoprotection by HMOX1"/>
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            <pathway-xref db="Reactome" id="R-SSC-5362517" name="Signaling by Retinoic Acid"/>
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            <pathway-xref db="Reactome" id="R-MMU-400206" name="Regulation of lipid metabolism by PPARalpha"/>
            <pathway-xref db="Reactome" id="R-HSA-8931987" name="RUNX1 regulates estrogen receptor mediated transcription"/>
            <pathway-xref db="Reactome" id="R-RNO-4090294" name="SUMOylation of intracellular receptors"/>
            <pathway-xref db="Reactome" id="R-HSA-2426168" name="Activation of gene expression by SREBF (SREBP)"/>
            <pathway-xref db="Reactome" id="R-RNO-400206" name="Regulation of lipid metabolism by PPARalpha"/>
            <pathway-xref db="Reactome" id="R-MMU-381340" name="Transcriptional regulation of white adipocyte differentiation"/>
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            <pathway-xref db="Reactome" id="R-HSA-210745" name="Regulation of gene expression in beta cells"/>
            <pathway-xref db="Reactome" id="R-HSA-9679191" name="Potential therapeutics for SARS"/>
            <pathway-xref db="Reactome" id="R-DRE-9623433" name="NR1H2 &amp; NR1H3 regulate gene expression to control bile acid homeostasis"/>
            <pathway-xref db="Reactome" id="R-MMU-8940973" name="RUNX2 regulates osteoblast differentiation"/>
            <pathway-xref db="Reactome" id="R-RNO-8939211" name="ESR-mediated signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-8939256" name="RUNX1 regulates transcription of genes involved in WNT signaling"/>
            <pathway-xref db="Reactome" id="R-CEL-204174" name="Regulation of pyruvate dehydrogenase (PDH) complex"/>
            <pathway-xref db="Reactome" id="R-DME-383280" name="Nuclear Receptor transcription pathway"/>
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            <pathway-xref db="Reactome" id="R-HSA-8949275" name="RUNX3 Regulates Immune Response and Cell Migration"/>
            <pathway-xref db="Reactome" id="R-BTA-383280" name="Nuclear Receptor transcription pathway"/>
            <pathway-xref db="Reactome" id="R-RNO-192105" name="Synthesis of bile acids and bile salts"/>
            <pathway-xref db="Reactome" id="R-HSA-3371497" name="HSP90 chaperone cycle for steroid hormone receptors (SHR)"/>
            <pathway-xref db="Reactome" id="R-GGA-9616222" name="Transcriptional regulation of granulopoiesis"/>
            <pathway-xref db="Reactome" id="R-CFA-200425" name="Carnitine metabolism"/>
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            <pathway-xref db="Reactome" id="R-DRE-400206" name="Regulation of lipid metabolism by PPARalpha"/>
            <pathway-xref db="Reactome" id="R-HSA-5689896" name="Ovarian tumor domain proteases"/>
            <pathway-xref db="Reactome" id="R-HSA-2219530" name="Constitutive Signaling by Aberrant PI3K in Cancer"/>
            <pathway-xref db="Reactome" id="R-RNO-5689896" name="Ovarian tumor domain proteases"/>
            <pathway-xref db="Reactome" id="R-RNO-198693" name="AKT phosphorylates targets in the nucleus"/>
            <pathway-xref db="Reactome" id="R-HSA-6785807" name="Interleukin-4 and Interleukin-13 signaling"/>
          </entry>
          <signature-library-release library="SUPERFAMILY" version="1.75"/>
        </signature>
        <model-ac>0042042</model-ac>
        <locations>
          <superfamilyhmmer3-location hmm-length="265" start="366" end="623">
            <location-fragments>
              <superfamilyhmmer3-location-fragment start="366" end="623" dc-status="CONTINUOUS"/>
            </location-fragments>
          </superfamilyhmmer3-location>
        </locations>
      </superfamilyhmmer3-match>
      <superfamilyhmmer3-match evalue="9.07E-27">
        <signature ac="SSF57716" name="Glucocorticoid receptor-like (DNA-binding domain)">
          <signature-library-release library="SUPERFAMILY" version="1.75"/>
        </signature>
        <model-ac>0053658</model-ac>
        <locations>
          <superfamilyhmmer3-location hmm-length="96" start="292" end="371">
            <location-fragments>
              <superfamilyhmmer3-location-fragment start="292" end="371" dc-status="CONTINUOUS"/>
            </location-fragments>
          </superfamilyhmmer3-location>
        </locations>
      </superfamilyhmmer3-match>
    </matches>
  </protein>
  <protein>
    <sequence md5="58426797f648e3288da0a8bcc3c113e5">MELKDEHKRLMMLILQQILEQQREVRQELQRIQRMQPQEGPPQQRPPPQQQQQPSLQKQLRELRSSHSKSRSSSRNKSRSKSRNKKYIEIHNTEEELGAQERVDMRNALEAAETSIAAAAETTNLCFTISKRVWPLSLLALRQTTKDLQLNRDYRDDESILRCDRAKEFECNSKNFIVENKNDIHVALKKHNNLFLKHVRXKKRHEIQQIAQICADCAQKSNARCIVDIGAGMGHLARSLAFKHNLCVICIEQDAELSQQARKWDQELLISLSKHLPNLSVNFPQHVSIKLESTNSDQSETIKDIXKIFSKDFNLNEKKSEFGIVGLHPCGDLAATLLKLYTSQHETRFICIVGCCYMKLTLEYPMDVSNGYPLSKYLLSFSNYKLSYTGLEVACHAIESYCDKLKTGNYKDLIVHAYRAVLETILMKQDKQLCHTQVRNVKVTNSMTFKQYCMAATANFEVHHQIEDLDFQDSQIMFYLSQWKHIVIFGALRTMLAPLVETIVLLDRFLYLSENQLSPILKPIFDARLSPRNFLLYSMKNIEQSLYI</sequence>
    <xref id="XP_029177653.1" name="XP_029177653.1 LOW QUALITY PROTEIN: protein RRNAD1-like [Nylanderia fulva]"/>
    <matches>
      <coils-match>
        <signature ac="Coil" name="Coil">
          <signature-library-release library="COILS" version="2.2.1"/>
        </signature>
        <model-ac>Coil</model-ac>
        <locations>
          <coils-location start="15" end="35">
            <location-fragments>
              <coils-location-fragment start="15" end="35" dc-status="CONTINUOUS"/>
            </location-fragments>
          </coils-location>
        </locations>
      </coils-match>
      <hmmer3-match evalue="2.3E-6" score="29.3">
        <signature ac="G3DSA:3.40.50.150" name="Vaccinia Virus protein VP39">
          <signature-library-release library="GENE3D" version="4.3.0"/>
        </signature>
        <model-ac>3ftdA01</model-ac>
        <locations>
          <hmmer3-location env-end="352" env-start="203" post-processed="true" score="28.3" evalue="4.9E-6" hmm-start="18" hmm-end="76" hmm-length="184" hmm-bounds="COMPLETE" start="203" end="352">
            <location-fragments>
              <hmmer3-location-fragment start="203" end="352" dc-status="CONTINUOUS"/>
            </location-fragments>
          </hmmer3-location>
        </locations>
      </hmmer3-match>
      <hmmer3-match evalue="3.3E-28" score="98.7">
        <signature ac="PF13679" desc="Methyltransferase domain" name="Methyltransf_32">
          <entry ac="IPR025714" desc="Methyltransferase domain" name="Methyltranfer_dom" type="DOMAIN">
            <pathway-xref db="MetaCyc" id="PWY-7695" name="aurofusarin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8238" name="24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)"/>
            <pathway-xref db="MetaCyc" id="PWY-6442" name="spermidine hydroxycinnamic acid conjugates biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7826" name="Amaryllidacea alkaloids biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7735" name="echinomycin and triostin A biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7161" name="polymethylated quercetin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5975" name="furaneol and mesifurane biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7694" name="zwittermicin A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-156581" name="Methylation"/>
            <pathway-xref db="MetaCyc" id="PWY-6739" name="pinitol biosynthesis II"/>
            <pathway-xref db="MetaCyc" id="PWY-7045" name="mithramycin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5" name="canavanine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8122" name="mycofactocin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6054" name="dimethylsulfoniopropanoate biosynthesis I (Wollastonia)"/>
            <pathway-xref db="MetaCyc" id="PWY-7354" name="aclacinomycin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7325" name="salvigenin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7752" name="gadusol biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7517" name="brassicicene C biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8035" name="streptovaricin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7150" name="polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)"/>
            <pathway-xref db="MetaCyc" id="PWY-7363" name="papaverine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7751" name="shinorine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7629" name="yatein biosynthesis II"/>
            <pathway-xref db="MetaCyc" id="PWY-5773" name="gossypol biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6973" name="dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8104" name="yangonin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6978" name="plastoquinol-9 biosynthesis II"/>
            <pathway-xref db="MetaCyc" id="PWY-7151" name="polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)"/>
            <pathway-xref db="MetaCyc" id="PWY-5479" name="6-methoxypodophyllotoxin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8100" name="crotonosine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-156581" name="Methylation"/>
            <pathway-xref db="MetaCyc" id="PWY-8076" name="8-O-methylated benzoxazinoid glucoside biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7668" name="apicidin F biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8047" name="bryostatin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6154" name="autoinducer AI-2 biosynthesis II (Vibrio)"/>
            <pathway-xref db="MetaCyc" id="PWY-7631" name="arctigenin and isoarctigenin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7534" name="gliotoxin inactivation"/>
            <pathway-xref db="MetaCyc" id="PWY-6148" name="tetrahydromethanopterin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-601" name="glucosinolate biosynthesis from tryptophan"/>
            <pathway-xref db="Reactome" id="R-HSA-8876725" name="Protein methylation"/>
            <pathway-xref db="MetaCyc" id="PWY-8257" name="Escherichia coli serotype O:52 O antigen biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7079" name="geodin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5105" name="hesperitin glycoside biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6519" name="8-amino-7-oxononanoate biosynthesis I"/>
            <pathway-xref db="MetaCyc" id="PWY-7352" name="daunorubicin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7163" name="polymethylated kaempferol biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8212" name="Escherichia coli serotype O:8 O antigen biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6931" name="seleno-amino acid detoxification and volatilization I"/>
            <pathway-xref db="MetaCyc" id="PWY-7692" name="bikaverin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7643" name="coniferyl alcohol 9-methyl ester biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8095" name="5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)"/>
            <pathway-xref db="MetaCyc" id="PWY-6045" name="methylthiopropanonate degradation II (demethylation)"/>
            <pathway-xref db="MetaCyc" id="PWY-7811" name="6-methylpretetramide biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7135" name="emetine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7439" name="dTDP-beta-L-evernitrose biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DRE-8876725" name="Protein methylation"/>
            <pathway-xref db="MetaCyc" id="PWY-7569" name="arginomycin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7186" name="superpathway of scopolin and esculin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8077" name="ginkgotoxin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7729" name="5,6-dimethylbenzimidazole biosynthesis II (anaerobic)"/>
            <pathway-xref db="MetaCyc" id="PWY-7498" name="phenylpropanoids methylation (ice plant)"/>
            <pathway-xref db="Reactome" id="R-SPO-8876725" name="Protein methylation"/>
            <pathway-xref db="MetaCyc" id="PWY-7157" name="eupatolitin 3-O-glucoside biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6955" name="lincomycin A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-389661" name="Glyoxylate metabolism and glycine degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7298" name="nevadensin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7742" name="phenolphthiocerol biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWYG-321" name="mycolate biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-6575" name="juvenile hormone III biosynthesis I"/>
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            <pathway-xref db="MetaCyc" id="PWY-6054" name="dimethylsulfoniopropanoate biosynthesis I (Wollastonia)"/>
            <pathway-xref db="MetaCyc" id="PWY-7354" name="aclacinomycin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7517" name="brassicicene C biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-75105" name="Fatty acyl-CoA biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7554" name="heme d1 biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7007" name="methyl ketone biosynthesis (engineered)"/>
            <pathway-xref db="MetaCyc" id="PWY-7530" name="Escherichia coli serotype O:104 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-XTR-8936459" name="RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"/>
            <pathway-xref db="MetaCyc" id="PWY-7573" name="GDP-mycosamine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7491" name="podophyllotoxin glucosides metabolism"/>
            <pathway-xref db="MetaCyc" id="PWY-5268" name="salvianin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-BTA-156581" name="Methylation"/>
            <pathway-xref db="MetaCyc" id="PWY-4061" name="glutathione-mediated detoxification I"/>
            <pathway-xref db="MetaCyc" id="PWY-7463" name="N-methylanthraniloyl-beta-D-glucopyranose biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7056" name="daphnin interconversion"/>
            <pathway-xref db="MetaCyc" id="PWY-5855" name="ubiquinol-7 biosynthesis (early decarboxylation)"/>
            <pathway-xref db="MetaCyc" id="PWY-8037" name="saliniketal A biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6673" name="caffeoylglucarate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9707564" name="Cytoprotection by HMOX1"/>
            <pathway-xref db="MetaCyc" id="PWY-5929" name="puromycin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-601" name="glucosinolate biosynthesis from tryptophan"/>
            <pathway-xref db="MetaCyc" id="PWY-6799" name="fatty acid biosynthesis initiation (plant mitochondria)"/>
            <pathway-xref db="MetaCyc" id="PWY-7656" name="Spodoptera littoralis pheromone biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SPO-6791226" name="Major pathway of rRNA processing in the nucleolus and cytosol"/>
            <pathway-xref db="MetaCyc" id="PWY-6453" name="stigma estolide biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5271" name="abscisic acid degradation to phaseic acid"/>
            <pathway-xref db="MetaCyc" id="PWY-7130" name="L-glucose degradation"/>
            <pathway-xref db="Reactome" id="R-SPO-2142789" name="Ubiquinol biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7159" name="3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent)"/>
            <pathway-xref db="MetaCyc" id="PWY-7995" name="tricin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5367" name="petroselinate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7692" name="bikaverin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7811" name="6-methylpretetramide biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-2541" name="phytosterol biosynthesis (plants)"/>
            <pathway-xref db="MetaCyc" id="PWY-6920" name="6-gingerol analog biosynthesis (engineered)"/>
            <pathway-xref db="MetaCyc" id="PWY-4203" name="volatile benzenoid biosynthesis I (ester formation)"/>
            <pathway-xref db="MetaCyc" id="PWY-7742" name="phenolphthiocerol biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DDI-70921" name="Histidine catabolism"/>
            <pathway-xref db="MetaCyc" id="PWY-7602" name="icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)"/>
            <pathway-xref db="MetaCyc" id="PWY-7706" name="dapdiamides biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7988" name="baumannoferrin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8172" name="10-methylstearate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7318" name="dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-379398" name="Enzymatic degradation of Dopamine by monoamine oxidase"/>
            <pathway-xref db="MetaCyc" id="PWY-7986" name="anguibactin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DDI-2142789" name="Ubiquinol biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-3214858" name="RMTs methylate histone arginines"/>
            <pathway-xref db="MetaCyc" id="PWY-6906" name="chitin derivatives degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7687" name="stipitatate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DDI-5676934" name="Protein repair"/>
            <pathway-xref db="MetaCyc" id="PWY-7375" name="mRNA capping I"/>
            <pathway-xref db="MetaCyc" id="PWY-6379" name="alcaligin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7074" name="phenylethanol glycoconjugate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7206" name="pyrimidine deoxyribonucleotides dephosphorylation"/>
            <pathway-xref db="Reactome" id="R-MMU-4655427" name="SUMOylation of DNA methylation proteins"/>
            <pathway-xref db="MetaCyc" id="PWY-6829" name="tRNA methylation (yeast)"/>
            <pathway-xref db="MetaCyc" id="PWY-5867" name="t-anethole biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7198" name="pyrimidine deoxyribonucleotides de novo biosynthesis IV"/>
            <pathway-xref db="MetaCyc" id="PWY-7042" name="the visual cycle (insects)"/>
            <pathway-xref db="MetaCyc" id="PWY-7730" name="T-2 toxin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-4161" name="superpathway of benzoxazinoid glucosides biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-400206" name="Regulation of lipid metabolism by PPARalpha"/>
            <pathway-xref db="MetaCyc" id="PWY-5315" name="N-methyl-Delta1-pyrrolinium cation biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5038" name="caffeine biosynthesis II (via paraxanthine)"/>
            <pathway-xref db="MetaCyc" id="PWY-7407" name="aurachin A, B, C and D biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6930" name="phenolic malonylglucosides biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6627" name="salinosporamide A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-5578995" name="Defective TPMT causes TPMT deficiency"/>
            <pathway-xref db="MetaCyc" id="PWY-6309" name="L-tryptophan degradation XI (mammalian, via kynurenine)"/>
            <pathway-xref db="Reactome" id="R-RNO-72086" name="mRNA Capping"/>
            <pathway-xref db="Reactome" id="R-SPO-5676934" name="Protein repair"/>
            <pathway-xref db="Reactome" id="R-DME-72086" name="mRNA Capping"/>
            <pathway-xref db="MetaCyc" id="PWY-6199" name="quercetin sulfate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5519" name="D-arabinose degradation III"/>
            <pathway-xref db="Reactome" id="R-SPO-379397" name="Enzymatic degradation of dopamine by COMT"/>
            <pathway-xref db="Reactome" id="R-CEL-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="MetaCyc" id="PWY-8080" name="kainate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6310" name="aloesone biosynthesis II"/>
            <pathway-xref db="Reactome" id="R-SPO-379398" name="Enzymatic degradation of Dopamine by monoamine oxidase"/>
            <pathway-xref db="MetaCyc" id="PWY-7405" name="aurachin RE biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7286" name="7-(3-amino-3-carboxypropyl)-wyosine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5818" name="validamycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-427413" name="NoRC negatively regulates rRNA expression"/>
            <pathway-xref db="MetaCyc" id="PWY-3901" name="berberine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5989" name="stearate biosynthesis II (bacteria and plants)"/>
            <pathway-xref db="MetaCyc" id="PWY-8155" name="testosterone degradation (anaerobic)"/>
            <pathway-xref db="MetaCyc" id="PWY-7072" name="hopanoid biosynthesis (bacteria)"/>
            <pathway-xref db="MetaCyc" id="PWY-7815" name="poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)"/>
            <pathway-xref db="Reactome" id="R-DME-9018519" name="Estrogen-dependent gene expression"/>
            <pathway-xref db="MetaCyc" id="PWY-5666" name="alpha-solanine/alpha-chaconine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-842" name="starch degradation I"/>
            <pathway-xref db="Reactome" id="R-CEL-6799198" name="Complex I biogenesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5290" name="secologanin and strictosidine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-71288" name="Creatine metabolism"/>
            <pathway-xref db="Reactome" id="R-HSA-6790901" name="rRNA modification in the nucleus and cytosol"/>
            <pathway-xref db="MetaCyc" id="PWY-7493" name="paxilline and diprenylpaxilline biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-156581" name="Methylation"/>
            <pathway-xref db="Reactome" id="R-DDI-3214858" name="RMTs methylate histone arginines"/>
            <pathway-xref db="MetaCyc" id="PWY-5794" name="malonate degradation I (biotin-independent)"/>
            <pathway-xref db="MetaCyc" id="PWY-5960" name="aflatoxins B2 and G2 biosynthesis"/>
            <pathway-xref db="Reactome" id="R-XTR-9018519" name="Estrogen-dependent gene expression"/>
            <pathway-xref db="MetaCyc" id="PWY-6339" name="syringate degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-5856" name="ubiquinol-9 biosynthesis (early decarboxylation)"/>
            <pathway-xref db="MetaCyc" id="PWY-7333" name="UDP-N-acetyl-alpha-D-fucosamine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-77075" name="RNA Pol II CTD phosphorylation and interaction with CE"/>
            <pathway-xref db="MetaCyc" id="PWY-7701" name="4-hydroxy-4-methyl-L-glutamate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5817" name="dodecaprenyl diphosphate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6053" name="dimethylsulfoniopropanoate biosynthesis III (algae and phytoplankton)"/>
            <pathway-xref db="MetaCyc" id="PWY-7825" name="juglone degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7076" name="3,5-dimethoxytoluene biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-209905" name="Catecholamine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-199220" name="Vitamin B5 (pantothenate) metabolism"/>
            <pathway-xref db="MetaCyc" id="PWY-7712" name="deoxynivalenol biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7339" name="10-trans-heptadecenoyl-CoA degradation (MFE-dependent, yeast)"/>
            <pathway-xref db="Reactome" id="R-HSA-71288" name="Creatine metabolism"/>
            <pathway-xref db="MetaCyc" id="PWY-5301" name="ajmaline and sarpagine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8043" name="ophthalmate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7984" name="acinetobactin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7414" name="dTDP-alpha-D-mycaminose biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DDI-6791226" name="Major pathway of rRNA processing in the nucleolus and cytosol"/>
            <pathway-xref db="Reactome" id="R-CEL-8876725" name="Protein methylation"/>
            <pathway-xref db="Reactome" id="R-RNO-77075" name="RNA Pol II CTD phosphorylation and interaction with CE"/>
            <pathway-xref db="MetaCyc" id="PWY-6792" name="scopoletin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7467" name="2-acetamido-4-amino-2,4,6-trideoxy-alpha-D-galactosyl-diphospho-ditrans,octacis-undecaprenol biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-212300" name="PRC2 methylates histones and DNA"/>
            <pathway-xref db="MetaCyc" id="PWY-7572" name="lolitrem B biosynthesis"/>
          </entry>
          <signature-library-release library="SUPERFAMILY" version="1.75"/>
        </signature>
        <model-ac>0040327</model-ac>
        <locations>
          <superfamilyhmmer3-location hmm-length="243" start="191" end="264">
            <location-fragments>
              <superfamilyhmmer3-location-fragment start="191" end="264" dc-status="CONTINUOUS"/>
            </location-fragments>
          </superfamilyhmmer3-location>
        </locations>
      </superfamilyhmmer3-match>
    </matches>
  </protein>
  <protein>
    <sequence md5="c3f6e51ec025f68571452b1f6ef2143d">MWFFILFYSLFILRKSETASDVISVKEVKAGHLAELPCLSIDEHHRFMFWQLGNNDVIGPGNPLNAKKYNYEVLTGTLQIRGVSTAESGFYKCISKGLFDESKLKINSVELIVKNDWEKVWENDFETNLLRGMTAVMVLVLAIAIVLLIITVKRKKSQRFFDLEESRDNSPARYTPNNAPGVSSSAENAGVDNAAVDIDFPKVFKQMQKEQAMP</sequence>
    <xref id="XP_029177656.1" name="XP_029177656.1 uncharacterized protein LOC114945565 isoform X2 [Nylanderia fulva]"/>
    <xref id="XP_029177657.1" name="XP_029177657.1 uncharacterized protein LOC114945565 isoform X2 [Nylanderia fulva]"/>
    <matches>
      <hmmer2-match evalue="7.5E-4" score="28.8">
        <signature ac="SM00409" name="IG_3c">
          <entry ac="IPR003599" desc="Immunoglobulin subtype" name="Ig_sub" type="DOMAIN">
            <pathway-xref db="Reactome" id="R-MMU-2173791" name="TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)"/>
            <pathway-xref db="Reactome" id="R-MMU-1474228" name="Degradation of the extracellular matrix"/>
            <pathway-xref db="Reactome" id="R-GGA-373920" name="Pyruvate metabolism"/>
            <pathway-xref db="MetaCyc" id="PWY-5461" name="betanidin degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-202733" name="Cell surface interactions at the vascular wall"/>
            <pathway-xref db="Reactome" id="R-DME-399954" name="Sema3A PAK dependent Axon repulsion"/>
            <pathway-xref db="Reactome" id="R-HSA-5673001" name="RAF/MAP kinase cascade"/>
            <pathway-xref db="Reactome" id="R-DME-428542" name="Regulation of commissural axon pathfinding by SLIT and ROBO"/>
            <pathway-xref db="Reactome" id="R-HSA-447038" name="NrCAM interactions"/>
            <pathway-xref db="Reactome" id="R-MMU-190377" name="FGFR2b ligand binding and activation"/>
            <pathway-xref db="Reactome" id="R-RNO-933542" name="TRAF6 mediated NF-kB activation"/>
            <pathway-xref db="Reactome" id="R-HSA-420597" name="Nectin/Necl trans heterodimerization"/>
            <pathway-xref db="Reactome" id="R-HSA-1474228" name="Degradation of the extracellular matrix"/>
            <pathway-xref db="Reactome" id="R-CEL-373752" name="Netrin-1 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-389948" name="PD-1 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-6807004" name="Negative regulation of MET activity"/>
            <pathway-xref db="Reactome" id="R-HSA-9032759" name="NTRK2 activates RAC1"/>
            <pathway-xref db="Reactome" id="R-MMU-2871796" name="FCERI mediated MAPK activation"/>
            <pathway-xref db="Reactome" id="R-HSA-877300" name="Interferon gamma signaling"/>
            <pathway-xref db="Reactome" id="R-CFA-983695" name="Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"/>
            <pathway-xref db="Reactome" id="R-MMU-2454202" name="Fc epsilon receptor (FCERI) signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-525793" name="Myogenesis"/>
            <pathway-xref db="Reactome" id="R-HSA-75892" name="Platelet Adhesion to exposed collagen"/>
            <pathway-xref db="Reactome" id="R-HSA-9013405" name="RHOD GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DRE-1433557" name="Signaling by SCF-KIT"/>
            <pathway-xref db="Reactome" id="R-HSA-9669934" name="Sunitinib-resistant KIT mutants"/>
            <pathway-xref db="Reactome" id="R-HSA-9620244" name="Long-term potentiation"/>
            <pathway-xref db="Reactome" id="R-MMU-418990" name="Adherens junctions interactions"/>
            <pathway-xref db="Reactome" id="R-MMU-202733" name="Cell surface interactions at the vascular wall"/>
            <pathway-xref db="Reactome" id="R-MMU-389948" name="PD-1 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-9014826" name="Interleukin-36 pathway"/>
            <pathway-xref db="Reactome" id="R-MMU-4420097" name="VEGFA-VEGFR2 Pathway"/>
            <pathway-xref db="Reactome" id="R-DRE-449836" name="Other interleukin signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-193648" name="NRAGE signals death through JNK"/>
            <pathway-xref db="Reactome" id="R-HSA-4420097" name="VEGFA-VEGFR2 Pathway"/>
            <pathway-xref db="Reactome" id="R-RNO-190373" name="FGFR1c ligand binding and activation"/>
            <pathway-xref db="Reactome" id="R-DME-399955" name="SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion"/>
            <pathway-xref db="Reactome" id="R-HSA-3656225" name="Defective CHST6 causes MCDC1"/>
            <pathway-xref db="Reactome" id="R-RNO-1462054" name="Alpha-defensins"/>
            <pathway-xref db="Reactome" id="R-HSA-8853336" name="Signaling by plasma membrane FGFR1 fusions"/>
            <pathway-xref db="Reactome" id="R-MMU-389356" name="CD28 co-stimulation"/>
            <pathway-xref db="Reactome" id="R-HSA-1839122" name="Signaling by activated point mutants of FGFR1"/>
            <pathway-xref db="Reactome" id="R-MMU-445095" name="Interaction between L1 and Ankyrins"/>
            <pathway-xref db="Reactome" id="R-GGA-210991" name="Basigin interactions"/>
            <pathway-xref db="Reactome" id="R-RNO-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-173623" name="Classical antibody-mediated complement activation"/>
            <pathway-xref db="Reactome" id="R-HSA-418990" name="Adherens junctions interactions"/>
            <pathway-xref db="Reactome" id="R-MMU-190375" name="FGFR2c ligand binding and activation"/>
            <pathway-xref db="Reactome" id="R-DME-190370" name="FGFR1b ligand binding and activation"/>
            <pathway-xref db="Reactome" id="R-HSA-2454202" name="Fc epsilon receptor (FCERI) signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-2871796" name="FCERI mediated MAPK activation"/>
            <pathway-xref db="Reactome" id="R-HSA-8863795" name="Downregulation of ERBB2 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-445095" name="Interaction between L1 and Ankyrins"/>
            <pathway-xref db="Reactome" id="R-CFA-1433557" name="Signaling by SCF-KIT"/>
            <pathway-xref db="Reactome" id="R-HSA-389356" name="CD28 co-stimulation"/>
            <pathway-xref db="Reactome" id="R-MMU-9013409" name="RHOJ GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-9013408" name="RHOG GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-190377" name="FGFR2b ligand binding and activation"/>
            <pathway-xref db="Reactome" id="R-SSC-198933" name="Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"/>
            <pathway-xref db="Reactome" id="R-HSA-2173791" name="TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)"/>
            <pathway-xref db="Reactome" id="R-DRE-5654704" name="SHC-mediated cascade:FGFR3"/>
            <pathway-xref db="Reactome" id="R-MMU-6807004" name="Negative regulation of MET activity"/>
            <pathway-xref db="Reactome" id="R-HSA-9603505" name="NTRK3 as a dependence receptor"/>
            <pathway-xref db="Reactome" id="R-MMU-2871837" name="FCERI mediated NF-kB activation"/>
            <pathway-xref db="Reactome" id="R-MMU-5654720" name="PI-3K cascade:FGFR4"/>
            <pathway-xref db="Reactome" id="R-HSA-388841" name="Costimulation by the CD28 family"/>
            <pathway-xref db="Reactome" id="R-HSA-3595172" name="Defective CHST3 causes SEDCJD"/>
            <pathway-xref db="Reactome" id="R-DRE-5654732" name="Negative regulation of FGFR3 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-5654720" name="PI-3K cascade:FGFR4"/>
            <pathway-xref db="Reactome" id="R-RNO-8849932" name="Synaptic adhesion-like molecules"/>
            <pathway-xref db="Reactome" id="R-DRE-194306" name="Neurophilin interactions with VEGF and VEGFR"/>
            <pathway-xref db="Reactome" id="R-MMU-166663" name="Initial triggering of complement"/>
            <pathway-xref db="Reactome" id="R-HSA-9034864" name="Activated NTRK3 signals through RAS"/>
            <pathway-xref db="Reactome" id="R-RNO-198933" name="Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell"/>
            <pathway-xref db="Reactome" id="R-HSA-190375" name="FGFR2c ligand binding and activation"/>
            <pathway-xref db="Reactome" id="R-RNO-170984" name="ARMS-mediated activation"/>
            <pathway-xref db="Reactome" id="R-RNO-6788467" name="IL-6-type cytokine receptor ligand interactions"/>
            <pathway-xref db="Reactome" id="R-DRE-388844" name="Receptor-type tyrosine-protein phosphatases"/>
            <pathway-xref db="Reactome" id="R-MMU-2022870" name="Chondroitin sulfate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-1963642" name="PI3K events in ERBB2 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-447043" name="Neurofascin interactions"/>
            <pathway-xref db="Reactome" id="R-MMU-420597" name="Nectin/Necl trans heterodimerization"/>
            <pathway-xref db="Reactome" id="R-HSA-416700" name="Other semaphorin interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-2023837" name="Signaling by FGFR2 amplification mutants"/>
            <pathway-xref db="Reactome" id="R-MMU-8951664" name="Neddylation"/>
            <pathway-xref db="Reactome" id="R-HSA-9674404" name="Sorafenib-resistant PDGFR mutants"/>
            <pathway-xref db="Reactome" id="R-HSA-5654219" name="Phospholipase C-mediated cascade: FGFR1"/>
            <pathway-xref db="Reactome" id="R-HSA-9007892" name="Interleukin-38 signaling"/>
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            <pathway-xref db="MetaCyc" id="PWY-7882" name="IM-2 type gamma-butyrolactones biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-DME-190372" name="FGFR3c ligand binding and activation"/>
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            <pathway-xref db="Reactome" id="R-SSC-9020591" name="Interleukin-12 signaling"/>
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            <pathway-xref db="Reactome" id="R-HSA-2132295" name="MHC class II antigen presentation"/>
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            <pathway-xref db="Reactome" id="R-HSA-9679191" name="Potential therapeutics for SARS"/>
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            <pathway-xref db="MetaCyc" id="PWY-5265" name="peptidoglycan biosynthesis II (staphylococci)"/>
            <pathway-xref db="Reactome" id="R-CEL-5620916" name="VxPx cargo-targeting to cilium"/>
            <pathway-xref db="MetaCyc" id="PWY-622" name="starch biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-MMU-9020591" name="Interleukin-12 signaling"/>
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            <pathway-xref db="MetaCyc" id="PWY-7981" name="alpha-dystroglycan glycosylation"/>
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            <pathway-xref db="Reactome" id="R-RNO-177504" name="Retrograde neurotrophin signalling"/>
            <pathway-xref db="MetaCyc" id="PWY-7547" name="prodigiosin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-2881" name="cytokinins 7-N-glucoside biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-DRE-190373" name="FGFR1c ligand binding and activation"/>
            <pathway-xref db="MetaCyc" id="PWY-5756" name="saponin biosynthesis II"/>
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            <pathway-xref db="MetaCyc" id="PWY-5339" name="chalcone 2'-O-glucoside biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-7256" name="cyanidin diglucoside biosynthesis (acyl-glucose dependent)"/>
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            <pathway-xref db="MetaCyc" id="PWY-7134" name="rutin degradation (plants)"/>
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            <pathway-xref db="Reactome" id="R-MMU-9014826" name="Interleukin-36 pathway"/>
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            <pathway-xref db="Reactome" id="R-DME-5654689" name="PI-3K cascade:FGFR1"/>
            <pathway-xref db="MetaCyc" id="PWY-7419" name="FR-900098 and FR-33289 antibiotics biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-RNO-9020956" name="Interleukin-27 signaling"/>
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            <pathway-xref db="MetaCyc" id="PWY-7950" name="diadinoxanthin and fucoxanthin biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-CFA-9020558" name="Interleukin-2 signaling"/>
            <pathway-xref db="Reactome" id="R-DRE-5654733" name="Negative regulation of FGFR4 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-7930" name="pyoluteorin biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-6842" name="glutathione-mediated detoxification II"/>
            <pathway-xref db="Reactome" id="R-GGA-983170" name="Antigen Presentation: Folding, assembly and peptide loading of class I MHC"/>
            <pathway-xref db="Reactome" id="R-RNO-8983432" name="Interleukin-15 signaling"/>
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            <pathway-xref db="MetaCyc" id="PWY-5161" name="6'-deoxychalcone metabolism"/>
            <pathway-xref db="Reactome" id="R-MMU-446107" name="Type I hemidesmosome assembly"/>
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            <pathway-xref db="Reactome" id="R-DRE-6811558" name="PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-8964038" name="LDL clearance"/>
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            <pathway-xref db="Reactome" id="R-DME-5673001" name="RAF/MAP kinase cascade"/>
            <pathway-xref db="Reactome" id="R-MMU-879415" name="Advanced glycosylation endproduct receptor signaling"/>
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            <pathway-xref db="Reactome" id="R-BTA-8980692" name="RHOA GTPase cycle"/>
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            <pathway-xref db="MetaCyc" id="PWY-6401" name="hispidol and hispidol 4'-O-beta-D-glucoside biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-RNO-446107" name="Type I hemidesmosome assembly"/>
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            <pathway-xref db="Reactome" id="R-RNO-5654733" name="Negative regulation of FGFR4 signaling"/>
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            <pathway-xref db="Reactome" id="R-RNO-390522" name="Striated Muscle Contraction"/>
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            <pathway-xref db="Reactome" id="R-RNO-212676" name="Dopamine Neurotransmitter Release Cycle"/>
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            <pathway-xref db="Reactome" id="R-RNO-198203" name="PI3K/AKT activation"/>
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            <pathway-xref db="Reactome" id="R-CFA-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-MMU-190373" name="FGFR1c ligand binding and activation"/>
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            <pathway-xref db="MetaCyc" id="PWY-1921" name="indole-3-acetate activation II"/>
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            <pathway-xref db="MetaCyc" id="PWY-7186" name="superpathway of scopolin and esculin biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-8082" name="glycine lipid biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-RNO-2871837" name="FCERI mediated NF-kB activation"/>
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            <pathway-xref db="Reactome" id="R-SSC-6798695" name="Neutrophil degranulation"/>
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            <pathway-xref db="Reactome" id="R-HSA-8854691" name="Interleukin-20 family signaling"/>
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            <pathway-xref db="MetaCyc" id="PWY-7252" name="luteolinidin 5-O-glucoside biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6575" name="juvenile hormone III biosynthesis I"/>
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            <pathway-xref db="Reactome" id="R-MMU-174577" name="Activation of C3 and C5"/>
            <pathway-xref db="MetaCyc" id="PWY-7058" name="esculetin modification"/>
            <pathway-xref db="Reactome" id="R-DRE-186763" name="Downstream signal transduction"/>
            <pathway-xref db="Reactome" id="R-DME-373752" name="Netrin-1 signaling"/>
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