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Entry type
Status
Per-residue features
Colour by
Protein
OTAU008613-PA
Length
843 amino acids
Protein family membership
- DNA topoisomerase, type IA (IPR000380)
Homologous superfamilies
-
Homologous superfamily4 - 597
- DNA topoisomerase, type IA, core domain (IPR023405)
-
Homologous superfamily176 - 593
-
Homologous superfamily235 - 491
-
Homologous superfamily296 - 422
1
100
200
300
400
500
600
700
843
Domains and repeats
-
Domain3 - 166
- TOPRIM domain (IPR006171)
- DNA topoisomerase 3-like, TOPRIM domain (IPR034144)
288 - 545- DNA topoisomerase, type IA, DNA-binding domain (IPR003602)
- TOPRIM domain (IPR006171)
-
Domain111 - 124
- DNA topoisomerase, type IA, central (IPR013497)
169 - 593- DNA topoisomerase, type IA, central (IPR013497)
-
Domain145 - 241
- DNA topoisomerase, type IA, domain 2 (IPR003601)
1
100
200
300
400
500
600
700
843
Detailed signature matches
-
-
G3DSA:1.10.46... (T...)492 - 593176 - 234
-
-
-
G3DSA:2.70.20.10 (T...)423 - 491235 - 295
-
-
-
G3DSA:1.10.29... (T...)296 - 422
-
-

Unintegrated signatures
-
1 - 169
-
PTHR11390:SF20 (DNA...)2 - 815
Other features
-
mobidb-lite (disord...)800 - 819
-
mobidb-lite (Positi...)800 - 816
Residue annotation
-
active site cd033629E10K13L116D118D120E
-
putative interdoma...16Sputative interdomain interaction site
16S, 117C, 119K, 126Y, 127E, 129M, 130N
CDD
cd03362 (TOPRIM_TopoIA_TopoIII)117Cputative interdomain interaction site
16S, 117C, 119K, 126Y, 127E, 129M, 130N
CDD
cd03362 (TOPRIM_TopoIA_TopoIII)119Kputative interdomain interaction site
16S, 117C, 119K, 126Y, 127E, 129M, 130N
CDD
cd03362 (TOPRIM_TopoIA_TopoIII)126Yputative interdomain interaction site
16S, 117C, 119K, 126Y, 127E, 129M, 130N
CDD
cd03362 (TOPRIM_TopoIA_TopoIII)127Eputative interdomain interaction site
16S, 117C, 119K, 126Y, 127E, 129M, 130N
CDD
cd03362 (TOPRIM_TopoIA_TopoIII)129Mputative interdomain interaction site
16S, 117C, 119K, 126Y, 127E, 129M, 130N
CDD
cd03362 (TOPRIM_TopoIA_TopoIII)130Nputative interdomain interaction site
16S, 117C, 119K, 126Y, 127E, 129M, 130N
CDD
cd03362 (TOPRIM_TopoIA_TopoIII) -
putative metal-bin...
-
putative nucleotid...119K
-
domain I cd00186171Edomain I
171E, 172N, 173E, 174A, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198F, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230T, 231I
CDD
cd00186 (TOP1Ac)172Ndomain I
171E, 172N, 173E, 174A, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198F, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230T, 231I
CDD
cd00186 (TOP1Ac)173Edomain I
171E, 172N, 173E, 174A, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198F, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230T, 231I
CDD
cd00186 (TOP1Ac)174Adomain I
171E, 172N, 173E, 174A, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198F, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230T, 231I
CDD
cd00186 (TOP1Ac)175Rdomain I
171E, 172N, 173E, 174A, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198F, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230T, 231I
CDD
cd00186 (TOP1Ac)176Sdomain I
171E, 172N, 173E, 174A, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198F, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230T, 231I
CDD
cd00186 (TOP1Ac)177Vdomain I
171E, 172N, 173E, 174A, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198F, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230T, 231I
CDD
cd00186 (TOP1Ac)178Ddomain I
171E, 172N, 173E, 174A, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198F, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230T, 231I
CDD
cd00186 (TOP1Ac)179Adomain I
171E, 172N, 173E, 174A, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198F, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230T, 231I
CDD
cd00186 (TOP1Ac)180Rdomain I
171E, 172N, 173E, 174A, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198F, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230T, 231I
CDD
cd00186 (TOP1Ac)181Qdomain I
171E, 172N, 173E, 174A, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198F, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230T, 231I
CDD
cd00186 (TOP1Ac)182Edomain I
171E, 172N, 173E, 174A, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198F, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230T, 231I
CDD
cd00186 (TOP1Ac)183Ldomain I
171E, 172N, 173E, 174A, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198F, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230T, 231I
CDD
cd00186 (TOP1Ac)184Ddomain I
171E, 172N, 173E, 174A, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198F, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230T, 231I
CDD
cd00186 (TOP1Ac)185Ldomain I
171E, 172N, 173E, 174A, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198F, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230T, 231I
CDD
cd00186 (TOP1Ac)186Rdomain I
171E, 172N, 173E, 174A, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198F, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230T, 231I
CDD
cd00186 (TOP1Ac)187Idomain I
171E, 172N, 173E, 174A, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198F, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230T, 231I
CDD
cd00186 (TOP1Ac)188Gdomain I
171E, 172N, 173E, 174A, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198F, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230T, 231I
CDD
cd00186 (TOP1Ac)189Cdomain I
171E, 172N, 173E, 174A, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198F, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230T, 231I
CDD
cd00186 (TOP1Ac)190Adomain I
171E, 172N, 173E, 174A, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198F, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230T, 231I
CDD
cd00186 (TOP1Ac)191Fdomain I
171E, 172N, 173E, 174A, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198F, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230T, 231I
CDD
cd00186 (TOP1Ac)192Tdomain I
171E, 172N, 173E, 174A, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198F, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230T, 231I
CDD
cd00186 (TOP1Ac)193Rdomain I
171E, 172N, 173E, 174A, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198F, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230T, 231I
CDD
cd00186 (TOP1Ac)194Fdomain I
171E, 172N, 173E, 174A, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198F, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230T, 231I
CDD
cd00186 (TOP1Ac)195Qdomain I
171E, 172N, 173E, 174A, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198F, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230T, 231I
CDD
cd00186 (TOP1Ac)196Tdomain I
171E, 172N, 173E, 174A, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198F, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230T, 231I
CDD
cd00186 (TOP1Ac)197Kdomain I
171E, 172N, 173E, 174A, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198F, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230T, 231I
CDD
cd00186 (TOP1Ac)198Fdomain I
171E, 172N, 173E, 174A, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198F, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230T, 231I
CDD
cd00186 (TOP1Ac)211Idomain I
171E, 172N, 173E, 174A, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198F, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230T, 231I
CDD
cd00186 (TOP1Ac)212Sdomain I
171E, 172N, 173E, 174A, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198F, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230T, 231I
CDD
cd00186 (TOP1Ac)213Ydomain I
171E, 172N, 173E, 174A, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198F, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230T, 231I
CDD
cd00186 (TOP1Ac)214Gdomain I
171E, 172N, 173E, 174A, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198F, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230T, 231I
CDD
cd00186 (TOP1Ac)215Pdomain I
171E, 172N, 173E, 174A, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198F, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230T, 231I
CDD
cd00186 (TOP1Ac)216Cdomain I
171E, 172N, 173E, 174A, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198F, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230T, 231I
CDD
cd00186 (TOP1Ac)217Qdomain I
171E, 172N, 173E, 174A, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198F, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230T, 231I
CDD
cd00186 (TOP1Ac)218Tdomain I
171E, 172N, 173E, 174A, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198F, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230T, 231I
CDD
cd00186 (TOP1Ac)219Pdomain I
171E, 172N, 173E, 174A, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198F, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230T, 231I
CDD
cd00186 (TOP1Ac)220Tdomain I
171E, 172N, 173E, 174A, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198F, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230T, 231I
CDD
cd00186 (TOP1Ac)221Ldomain I
171E, 172N, 173E, 174A, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198F, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230T, 231I
CDD
cd00186 (TOP1Ac)222Gdomain I
171E, 172N, 173E, 174A, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198F, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230T, 231I
CDD
cd00186 (TOP1Ac)223Fdomain I
171E, 172N, 173E, 174A, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198F, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230T, 231I
CDD
cd00186 (TOP1Ac)224Cdomain I
171E, 172N, 173E, 174A, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198F, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230T, 231I
CDD
cd00186 (TOP1Ac)225Vdomain I
171E, 172N, 173E, 174A, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198F, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230T, 231I
CDD
cd00186 (TOP1Ac)226Qdomain I
171E, 172N, 173E, 174A, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198F, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230T, 231I
CDD
cd00186 (TOP1Ac)227Rdomain I
171E, 172N, 173E, 174A, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198F, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230T, 231I
CDD
cd00186 (TOP1Ac)228Hdomain I
171E, 172N, 173E, 174A, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198F, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230T, 231I
CDD
cd00186 (TOP1Ac)229Ddomain I
171E, 172N, 173E, 174A, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198F, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230T, 231I
CDD
cd00186 (TOP1Ac)230Tdomain I
171E, 172N, 173E, 174A, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198F, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230T, 231I
CDD
cd00186 (TOP1Ac)231Idomain I
171E, 172N, 173E, 174A, 175R, 176S, 177V, 178D, 179A, 180R, 181Q, 182E, 183L, 184D, 185L, 186R, 187I, 188G, 189C, 190A, 191F, 192T, 193R, 194F, 195Q, 196T, 197K, 198F, 211I, 212S, 213Y, 214G, 215P, 216C, 217Q, 218T, 219P, 220T, 221L, 222G, 223F, 224C, 225V, 226Q, 227R, 228H, 229D, 230T, 231I
CDD
cd00186 (TOP1Ac) -
DNA binding groove...180RDNA binding groove
180R, 181Q, 184D, 188G, 192T, 325E, 329T, 337R, 512A, 513S, 516V, 517H, 519N, 523Q, 524R
CDD
cd00186 (TOP1Ac)181QDNA binding groove
180R, 181Q, 184D, 188G, 192T, 325E, 329T, 337R, 512A, 513S, 516V, 517H, 519N, 523Q, 524R
CDD
cd00186 (TOP1Ac)184DDNA binding groove
180R, 181Q, 184D, 188G, 192T, 325E, 329T, 337R, 512A, 513S, 516V, 517H, 519N, 523Q, 524R
CDD
cd00186 (TOP1Ac)188GDNA binding groove
180R, 181Q, 184D, 188G, 192T, 325E, 329T, 337R, 512A, 513S, 516V, 517H, 519N, 523Q, 524R
CDD
cd00186 (TOP1Ac)192TDNA binding groove
180R, 181Q, 184D, 188G, 192T, 325E, 329T, 337R, 512A, 513S, 516V, 517H, 519N, 523Q, 524R
CDD
cd00186 (TOP1Ac)325EDNA binding groove
180R, 181Q, 184D, 188G, 192T, 325E, 329T, 337R, 512A, 513S, 516V, 517H, 519N, 523Q, 524R
CDD
cd00186 (TOP1Ac)329TDNA binding groove
180R, 181Q, 184D, 188G, 192T, 325E, 329T, 337R, 512A, 513S, 516V, 517H, 519N, 523Q, 524R
CDD
cd00186 (TOP1Ac)337RDNA binding groove
180R, 181Q, 184D, 188G, 192T, 325E, 329T, 337R, 512A, 513S, 516V, 517H, 519N, 523Q, 524R
CDD
cd00186 (TOP1Ac)512ADNA binding groove
180R, 181Q, 184D, 188G, 192T, 325E, 329T, 337R, 512A, 513S, 516V, 517H, 519N, 523Q, 524R
CDD
cd00186 (TOP1Ac)513SDNA binding groove
180R, 181Q, 184D, 188G, 192T, 325E, 329T, 337R, 512A, 513S, 516V, 517H, 519N, 523Q, 524R
CDD
cd00186 (TOP1Ac)516VDNA binding groove
180R, 181Q, 184D, 188G, 192T, 325E, 329T, 337R, 512A, 513S, 516V, 517H, 519N, 523Q, 524R
CDD
cd00186 (TOP1Ac)517HDNA binding groove
180R, 181Q, 184D, 188G, 192T, 325E, 329T, 337R, 512A, 513S, 516V, 517H, 519N, 523Q, 524R
CDD
cd00186 (TOP1Ac)519NDNA binding groove
180R, 181Q, 184D, 188G, 192T, 325E, 329T, 337R, 512A, 513S, 516V, 517H, 519N, 523Q, 524R
CDD
cd00186 (TOP1Ac)523QDNA binding groove
180R, 181Q, 184D, 188G, 192T, 325E, 329T, 337R, 512A, 513S, 516V, 517H, 519N, 523Q, 524R
CDD
cd00186 (TOP1Ac)524RDNA binding groove
180R, 181Q, 184D, 188G, 192T, 325E, 329T, 337R, 512A, 513S, 516V, 517H, 519N, 523Q, 524R
CDD
cd00186 (TOP1Ac) -
phosphate binding ...
-
domain II cd00186236Sdomain II
236S, 237E, 238P, 239Y, 240W, 241V, 242V, 243Q, 281Q, 282S, 283Q, 284V, 285T, 286K, 287I, 288T, 289R, 290K, 291E, 292K, 293A, 294K, 295S, 422K, 423D, 424C, 425K, 426Y, 427L, 428S, 429T, 430T, 431I, 432T, 433F, 434L, 435I, 436N, 438E, 439I, 440F, 441T, 442A, 443T, 444G, 445K, 446T, 447L, 448I, 449D, 450P, 451G, 452F, 453T, 454T, 455I, 456M, 479Q, 480E, 481T, 482K, 483L, 484V, 485E, 486Y, 487Q, 488T, 489N
CDD
cd00186 (TOP1Ac)237Edomain II
236S, 237E, 238P, 239Y, 240W, 241V, 242V, 243Q, 281Q, 282S, 283Q, 284V, 285T, 286K, 287I, 288T, 289R, 290K, 291E, 292K, 293A, 294K, 295S, 422K, 423D, 424C, 425K, 426Y, 427L, 428S, 429T, 430T, 431I, 432T, 433F, 434L, 435I, 436N, 438E, 439I, 440F, 441T, 442A, 443T, 444G, 445K, 446T, 447L, 448I, 449D, 450P, 451G, 452F, 453T, 454T, 455I, 456M, 479Q, 480E, 481T, 482K, 483L, 484V, 485E, 486Y, 487Q, 488T, 489N
CDD
cd00186 (TOP1Ac)238Pdomain II
236S, 237E, 238P, 239Y, 240W, 241V, 242V, 243Q, 281Q, 282S, 283Q, 284V, 285T, 286K, 287I, 288T, 289R, 290K, 291E, 292K, 293A, 294K, 295S, 422K, 423D, 424C, 425K, 426Y, 427L, 428S, 429T, 430T, 431I, 432T, 433F, 434L, 435I, 436N, 438E, 439I, 440F, 441T, 442A, 443T, 444G, 445K, 446T, 447L, 448I, 449D, 450P, 451G, 452F, 453T, 454T, 455I, 456M, 479Q, 480E, 481T, 482K, 483L, 484V, 485E, 486Y, 487Q, 488T, 489N
CDD
cd00186 (TOP1Ac)239Ydomain II
236S, 237E, 238P, 239Y, 240W, 241V, 242V, 243Q, 281Q, 282S, 283Q, 284V, 285T, 286K, 287I, 288T, 289R, 290K, 291E, 292K, 293A, 294K, 295S, 422K, 423D, 424C, 425K, 426Y, 427L, 428S, 429T, 430T, 431I, 432T, 433F, 434L, 435I, 436N, 438E, 439I, 440F, 441T, 442A, 443T, 444G, 445K, 446T, 447L, 448I, 449D, 450P, 451G, 452F, 453T, 454T, 455I, 456M, 479Q, 480E, 481T, 482K, 483L, 484V, 485E, 486Y, 487Q, 488T, 489N
CDD
cd00186 (TOP1Ac)240Wdomain II
236S, 237E, 238P, 239Y, 240W, 241V, 242V, 243Q, 281Q, 282S, 283Q, 284V, 285T, 286K, 287I, 288T, 289R, 290K, 291E, 292K, 293A, 294K, 295S, 422K, 423D, 424C, 425K, 426Y, 427L, 428S, 429T, 430T, 431I, 432T, 433F, 434L, 435I, 436N, 438E, 439I, 440F, 441T, 442A, 443T, 444G, 445K, 446T, 447L, 448I, 449D, 450P, 451G, 452F, 453T, 454T, 455I, 456M, 479Q, 480E, 481T, 482K, 483L, 484V, 485E, 486Y, 487Q, 488T, 489N
CDD
cd00186 (TOP1Ac)241Vdomain II
236S, 237E, 238P, 239Y, 240W, 241V, 242V, 243Q, 281Q, 282S, 283Q, 284V, 285T, 286K, 287I, 288T, 289R, 290K, 291E, 292K, 293A, 294K, 295S, 422K, 423D, 424C, 425K, 426Y, 427L, 428S, 429T, 430T, 431I, 432T, 433F, 434L, 435I, 436N, 438E, 439I, 440F, 441T, 442A, 443T, 444G, 445K, 446T, 447L, 448I, 449D, 450P, 451G, 452F, 453T, 454T, 455I, 456M, 479Q, 480E, 481T, 482K, 483L, 484V, 485E, 486Y, 487Q, 488T, 489N
CDD
cd00186 (TOP1Ac)242Vdomain II
236S, 237E, 238P, 239Y, 240W, 241V, 242V, 243Q, 281Q, 282S, 283Q, 284V, 285T, 286K, 287I, 288T, 289R, 290K, 291E, 292K, 293A, 294K, 295S, 422K, 423D, 424C, 425K, 426Y, 427L, 428S, 429T, 430T, 431I, 432T, 433F, 434L, 435I, 436N, 438E, 439I, 440F, 441T, 442A, 443T, 444G, 445K, 446T, 447L, 448I, 449D, 450P, 451G, 452F, 453T, 454T, 455I, 456M, 479Q, 480E, 481T, 482K, 483L, 484V, 485E, 486Y, 487Q, 488T, 489N
CDD
cd00186 (TOP1Ac)243Qdomain II
236S, 237E, 238P, 239Y, 240W, 241V, 242V, 243Q, 281Q, 282S, 283Q, 284V, 285T, 286K, 287I, 288T, 289R, 290K, 291E, 292K, 293A, 294K, 295S, 422K, 423D, 424C, 425K, 426Y, 427L, 428S, 429T, 430T, 431I, 432T, 433F, 434L, 435I, 436N, 438E, 439I, 440F, 441T, 442A, 443T, 444G, 445K, 446T, 447L, 448I, 449D, 450P, 451G, 452F, 453T, 454T, 455I, 456M, 479Q, 480E, 481T, 482K, 483L, 484V, 485E, 486Y, 487Q, 488T, 489N
CDD
cd00186 (TOP1Ac)281Qdomain II
236S, 237E, 238P, 239Y, 240W, 241V, 242V, 243Q, 281Q, 282S, 283Q, 284V, 285T, 286K, 287I, 288T, 289R, 290K, 291E, 292K, 293A, 294K, 295S, 422K, 423D, 424C, 425K, 426Y, 427L, 428S, 429T, 430T, 431I, 432T, 433F, 434L, 435I, 436N, 438E, 439I, 440F, 441T, 442A, 443T, 444G, 445K, 446T, 447L, 448I, 449D, 450P, 451G, 452F, 453T, 454T, 455I, 456M, 479Q, 480E, 481T, 482K, 483L, 484V, 485E, 486Y, 487Q, 488T, 489N
CDD
cd00186 (TOP1Ac)282Sdomain II
236S, 237E, 238P, 239Y, 240W, 241V, 242V, 243Q, 281Q, 282S, 283Q, 284V, 285T, 286K, 287I, 288T, 289R, 290K, 291E, 292K, 293A, 294K, 295S, 422K, 423D, 424C, 425K, 426Y, 427L, 428S, 429T, 430T, 431I, 432T, 433F, 434L, 435I, 436N, 438E, 439I, 440F, 441T, 442A, 443T, 444G, 445K, 446T, 447L, 448I, 449D, 450P, 451G, 452F, 453T, 454T, 455I, 456M, 479Q, 480E, 481T, 482K, 483L, 484V, 485E, 486Y, 487Q, 488T, 489N
CDD
cd00186 (TOP1Ac)283Qdomain II
236S, 237E, 238P, 239Y, 240W, 241V, 242V, 243Q, 281Q, 282S, 283Q, 284V, 285T, 286K, 287I, 288T, 289R, 290K, 291E, 292K, 293A, 294K, 295S, 422K, 423D, 424C, 425K, 426Y, 427L, 428S, 429T, 430T, 431I, 432T, 433F, 434L, 435I, 436N, 438E, 439I, 440F, 441T, 442A, 443T, 444G, 445K, 446T, 447L, 448I, 449D, 450P, 451G, 452F, 453T, 454T, 455I, 456M, 479Q, 480E, 481T, 482K, 483L, 484V, 485E, 486Y, 487Q, 488T, 489N
CDD
cd00186 (TOP1Ac)284Vdomain II
236S, 237E, 238P, 239Y, 240W, 241V, 242V, 243Q, 281Q, 282S, 283Q, 284V, 285T, 286K, 287I, 288T, 289R, 290K, 291E, 292K, 293A, 294K, 295S, 422K, 423D, 424C, 425K, 426Y, 427L, 428S, 429T, 430T, 431I, 432T, 433F, 434L, 435I, 436N, 438E, 439I, 440F, 441T, 442A, 443T, 444G, 445K, 446T, 447L, 448I, 449D, 450P, 451G, 452F, 453T, 454T, 455I, 456M, 479Q, 480E, 481T, 482K, 483L, 484V, 485E, 486Y, 487Q, 488T, 489N
CDD
cd00186 (TOP1Ac)285Tdomain II
236S, 237E, 238P, 239Y, 240W, 241V, 242V, 243Q, 281Q, 282S, 283Q, 284V, 285T, 286K, 287I, 288T, 289R, 290K, 291E, 292K, 293A, 294K, 295S, 422K, 423D, 424C, 425K, 426Y, 427L, 428S, 429T, 430T, 431I, 432T, 433F, 434L, 435I, 436N, 438E, 439I, 440F, 441T, 442A, 443T, 444G, 445K, 446T, 447L, 448I, 449D, 450P, 451G, 452F, 453T, 454T, 455I, 456M, 479Q, 480E, 481T, 482K, 483L, 484V, 485E, 486Y, 487Q, 488T, 489N
CDD
cd00186 (TOP1Ac)286Kdomain II
236S, 237E, 238P, 239Y, 240W, 241V, 242V, 243Q, 281Q, 282S, 283Q, 284V, 285T, 286K, 287I, 288T, 289R, 290K, 291E, 292K, 293A, 294K, 295S, 422K, 423D, 424C, 425K, 426Y, 427L, 428S, 429T, 430T, 431I, 432T, 433F, 434L, 435I, 436N, 438E, 439I, 440F, 441T, 442A, 443T, 444G, 445K, 446T, 447L, 448I, 449D, 450P, 451G, 452F, 453T, 454T, 455I, 456M, 479Q, 480E, 481T, 482K, 483L, 484V, 485E, 486Y, 487Q, 488T, 489N
CDD
cd00186 (TOP1Ac)287Idomain II
236S, 237E, 238P, 239Y, 240W, 241V, 242V, 243Q, 281Q, 282S, 283Q, 284V, 285T, 286K, 287I, 288T, 289R, 290K, 291E, 292K, 293A, 294K, 295S, 422K, 423D, 424C, 425K, 426Y, 427L, 428S, 429T, 430T, 431I, 432T, 433F, 434L, 435I, 436N, 438E, 439I, 440F, 441T, 442A, 443T, 444G, 445K, 446T, 447L, 448I, 449D, 450P, 451G, 452F, 453T, 454T, 455I, 456M, 479Q, 480E, 481T, 482K, 483L, 484V, 485E, 486Y, 487Q, 488T, 489N
CDD
cd00186 (TOP1Ac)288Tdomain II
236S, 237E, 238P, 239Y, 240W, 241V, 242V, 243Q, 281Q, 282S, 283Q, 284V, 285T, 286K, 287I, 288T, 289R, 290K, 291E, 292K, 293A, 294K, 295S, 422K, 423D, 424C, 425K, 426Y, 427L, 428S, 429T, 430T, 431I, 432T, 433F, 434L, 435I, 436N, 438E, 439I, 440F, 441T, 442A, 443T, 444G, 445K, 446T, 447L, 448I, 449D, 450P, 451G, 452F, 453T, 454T, 455I, 456M, 479Q, 480E, 481T, 482K, 483L, 484V, 485E, 486Y, 487Q, 488T, 489N
CDD
cd00186 (TOP1Ac)289Rdomain II
236S, 237E, 238P, 239Y, 240W, 241V, 242V, 243Q, 281Q, 282S, 283Q, 284V, 285T, 286K, 287I, 288T, 289R, 290K, 291E, 292K, 293A, 294K, 295S, 422K, 423D, 424C, 425K, 426Y, 427L, 428S, 429T, 430T, 431I, 432T, 433F, 434L, 435I, 436N, 438E, 439I, 440F, 441T, 442A, 443T, 444G, 445K, 446T, 447L, 448I, 449D, 450P, 451G, 452F, 453T, 454T, 455I, 456M, 479Q, 480E, 481T, 482K, 483L, 484V, 485E, 486Y, 487Q, 488T, 489N
CDD
cd00186 (TOP1Ac)290Kdomain II
236S, 237E, 238P, 239Y, 240W, 241V, 242V, 243Q, 281Q, 282S, 283Q, 284V, 285T, 286K, 287I, 288T, 289R, 290K, 291E, 292K, 293A, 294K, 295S, 422K, 423D, 424C, 425K, 426Y, 427L, 428S, 429T, 430T, 431I, 432T, 433F, 434L, 435I, 436N, 438E, 439I, 440F, 441T, 442A, 443T, 444G, 445K, 446T, 447L, 448I, 449D, 450P, 451G, 452F, 453T, 454T, 455I, 456M, 479Q, 480E, 481T, 482K, 483L, 484V, 485E, 486Y, 487Q, 488T, 489N
CDD
cd00186 (TOP1Ac)291Edomain II
236S, 237E, 238P, 239Y, 240W, 241V, 242V, 243Q, 281Q, 282S, 283Q, 284V, 285T, 286K, 287I, 288T, 289R, 290K, 291E, 292K, 293A, 294K, 295S, 422K, 423D, 424C, 425K, 426Y, 427L, 428S, 429T, 430T, 431I, 432T, 433F, 434L, 435I, 436N, 438E, 439I, 440F, 441T, 442A, 443T, 444G, 445K, 446T, 447L, 448I, 449D, 450P, 451G, 452F, 453T, 454T, 455I, 456M, 479Q, 480E, 481T, 482K, 483L, 484V, 485E, 486Y, 487Q, 488T, 489N
CDD
cd00186 (TOP1Ac)292Kdomain II
236S, 237E, 238P, 239Y, 240W, 241V, 242V, 243Q, 281Q, 282S, 283Q, 284V, 285T, 286K, 287I, 288T, 289R, 290K, 291E, 292K, 293A, 294K, 295S, 422K, 423D, 424C, 425K, 426Y, 427L, 428S, 429T, 430T, 431I, 432T, 433F, 434L, 435I, 436N, 438E, 439I, 440F, 441T, 442A, 443T, 444G, 445K, 446T, 447L, 448I, 449D, 450P, 451G, 452F, 453T, 454T, 455I, 456M, 479Q, 480E, 481T, 482K, 483L, 484V, 485E, 486Y, 487Q, 488T, 489N
CDD
cd00186 (TOP1Ac)293Adomain II
236S, 237E, 238P, 239Y, 240W, 241V, 242V, 243Q, 281Q, 282S, 283Q, 284V, 285T, 286K, 287I, 288T, 289R, 290K, 291E, 292K, 293A, 294K, 295S, 422K, 423D, 424C, 425K, 426Y, 427L, 428S, 429T, 430T, 431I, 432T, 433F, 434L, 435I, 436N, 438E, 439I, 440F, 441T, 442A, 443T, 444G, 445K, 446T, 447L, 448I, 449D, 450P, 451G, 452F, 453T, 454T, 455I, 456M, 479Q, 480E, 481T, 482K, 483L, 484V, 485E, 486Y, 487Q, 488T, 489N
CDD
cd00186 (TOP1Ac)294Kdomain II
236S, 237E, 238P, 239Y, 240W, 241V, 242V, 243Q, 281Q, 282S, 283Q, 284V, 285T, 286K, 287I, 288T, 289R, 290K, 291E, 292K, 293A, 294K, 295S, 422K, 423D, 424C, 425K, 426Y, 427L, 428S, 429T, 430T, 431I, 432T, 433F, 434L, 435I, 436N, 438E, 439I, 440F, 441T, 442A, 443T, 444G, 445K, 446T, 447L, 448I, 449D, 450P, 451G, 452F, 453T, 454T, 455I, 456M, 479Q, 480E, 481T, 482K, 483L, 484V, 485E, 486Y, 487Q, 488T, 489N
CDD
cd00186 (TOP1Ac)295Sdomain II
236S, 237E, 238P, 239Y, 240W, 241V, 242V, 243Q, 281Q, 282S, 283Q, 284V, 285T, 286K, 287I, 288T, 289R, 290K, 291E, 292K, 293A, 294K, 295S, 422K, 423D, 424C, 425K, 426Y, 427L, 428S, 429T, 430T, 431I, 432T, 433F, 434L, 435I, 436N, 438E, 439I, 440F, 441T, 442A, 443T, 444G, 445K, 446T, 447L, 448I, 449D, 450P, 451G, 452F, 453T, 454T, 455I, 456M, 479Q, 480E, 481T, 482K, 483L, 484V, 485E, 486Y, 487Q, 488T, 489N
CDD
cd00186 (TOP1Ac)422Kdomain II
236S, 237E, 238P, 239Y, 240W, 241V, 242V, 243Q, 281Q, 282S, 283Q, 284V, 285T, 286K, 287I, 288T, 289R, 290K, 291E, 292K, 293A, 294K, 295S, 422K, 423D, 424C, 425K, 426Y, 427L, 428S, 429T, 430T, 431I, 432T, 433F, 434L, 435I, 436N, 438E, 439I, 440F, 441T, 442A, 443T, 444G, 445K, 446T, 447L, 448I, 449D, 450P, 451G, 452F, 453T, 454T, 455I, 456M, 479Q, 480E, 481T, 482K, 483L, 484V, 485E, 486Y, 487Q, 488T, 489N
CDD
cd00186 (TOP1Ac)423Ddomain II
236S, 237E, 238P, 239Y, 240W, 241V, 242V, 243Q, 281Q, 282S, 283Q, 284V, 285T, 286K, 287I, 288T, 289R, 290K, 291E, 292K, 293A, 294K, 295S, 422K, 423D, 424C, 425K, 426Y, 427L, 428S, 429T, 430T, 431I, 432T, 433F, 434L, 435I, 436N, 438E, 439I, 440F, 441T, 442A, 443T, 444G, 445K, 446T, 447L, 448I, 449D, 450P, 451G, 452F, 453T, 454T, 455I, 456M, 479Q, 480E, 481T, 482K, 483L, 484V, 485E, 486Y, 487Q, 488T, 489N
CDD
cd00186 (TOP1Ac)424Cdomain II
236S, 237E, 238P, 239Y, 240W, 241V, 242V, 243Q, 281Q, 282S, 283Q, 284V, 285T, 286K, 287I, 288T, 289R, 290K, 291E, 292K, 293A, 294K, 295S, 422K, 423D, 424C, 425K, 426Y, 427L, 428S, 429T, 430T, 431I, 432T, 433F, 434L, 435I, 436N, 438E, 439I, 440F, 441T, 442A, 443T, 444G, 445K, 446T, 447L, 448I, 449D, 450P, 451G, 452F, 453T, 454T, 455I, 456M, 479Q, 480E, 481T, 482K, 483L, 484V, 485E, 486Y, 487Q, 488T, 489N
CDD
cd00186 (TOP1Ac)425Kdomain II
236S, 237E, 238P, 239Y, 240W, 241V, 242V, 243Q, 281Q, 282S, 283Q, 284V, 285T, 286K, 287I, 288T, 289R, 290K, 291E, 292K, 293A, 294K, 295S, 422K, 423D, 424C, 425K, 426Y, 427L, 428S, 429T, 430T, 431I, 432T, 433F, 434L, 435I, 436N, 438E, 439I, 440F, 441T, 442A, 443T, 444G, 445K, 446T, 447L, 448I, 449D, 450P, 451G, 452F, 453T, 454T, 455I, 456M, 479Q, 480E, 481T, 482K, 483L, 484V, 485E, 486Y, 487Q, 488T, 489N
CDD
cd00186 (TOP1Ac)426Ydomain II
236S, 237E, 238P, 239Y, 240W, 241V, 242V, 243Q, 281Q, 282S, 283Q, 284V, 285T, 286K, 287I, 288T, 289R, 290K, 291E, 292K, 293A, 294K, 295S, 422K, 423D, 424C, 425K, 426Y, 427L, 428S, 429T, 430T, 431I, 432T, 433F, 434L, 435I, 436N, 438E, 439I, 440F, 441T, 442A, 443T, 444G, 445K, 446T, 447L, 448I, 449D, 450P, 451G, 452F, 453T, 454T, 455I, 456M, 479Q, 480E, 481T, 482K, 483L, 484V, 485E, 486Y, 487Q, 488T, 489N
CDD
cd00186 (TOP1Ac)427Ldomain II
236S, 237E, 238P, 239Y, 240W, 241V, 242V, 243Q, 281Q, 282S, 283Q, 284V, 285T, 286K, 287I, 288T, 289R, 290K, 291E, 292K, 293A, 294K, 295S, 422K, 423D, 424C, 425K, 426Y, 427L, 428S, 429T, 430T, 431I, 432T, 433F, 434L, 435I, 436N, 438E, 439I, 440F, 441T, 442A, 443T, 444G, 445K, 446T, 447L, 448I, 449D, 450P, 451G, 452F, 453T, 454T, 455I, 456M, 479Q, 480E, 481T, 482K, 483L, 484V, 485E, 486Y, 487Q, 488T, 489N
CDD
cd00186 (TOP1Ac)428Sdomain II
236S, 237E, 238P, 239Y, 240W, 241V, 242V, 243Q, 281Q, 282S, 283Q, 284V, 285T, 286K, 287I, 288T, 289R, 290K, 291E, 292K, 293A, 294K, 295S, 422K, 423D, 424C, 425K, 426Y, 427L, 428S, 429T, 430T, 431I, 432T, 433F, 434L, 435I, 436N, 438E, 439I, 440F, 441T, 442A, 443T, 444G, 445K, 446T, 447L, 448I, 449D, 450P, 451G, 452F, 453T, 454T, 455I, 456M, 479Q, 480E, 481T, 482K, 483L, 484V, 485E, 486Y, 487Q, 488T, 489N
CDD
cd00186 (TOP1Ac)429Tdomain II
236S, 237E, 238P, 239Y, 240W, 241V, 242V, 243Q, 281Q, 282S, 283Q, 284V, 285T, 286K, 287I, 288T, 289R, 290K, 291E, 292K, 293A, 294K, 295S, 422K, 423D, 424C, 425K, 426Y, 427L, 428S, 429T, 430T, 431I, 432T, 433F, 434L, 435I, 436N, 438E, 439I, 440F, 441T, 442A, 443T, 444G, 445K, 446T, 447L, 448I, 449D, 450P, 451G, 452F, 453T, 454T, 455I, 456M, 479Q, 480E, 481T, 482K, 483L, 484V, 485E, 486Y, 487Q, 488T, 489N
CDD
cd00186 (TOP1Ac)430Tdomain II
236S, 237E, 238P, 239Y, 240W, 241V, 242V, 243Q, 281Q, 282S, 283Q, 284V, 285T, 286K, 287I, 288T, 289R, 290K, 291E, 292K, 293A, 294K, 295S, 422K, 423D, 424C, 425K, 426Y, 427L, 428S, 429T, 430T, 431I, 432T, 433F, 434L, 435I, 436N, 438E, 439I, 440F, 441T, 442A, 443T, 444G, 445K, 446T, 447L, 448I, 449D, 450P, 451G, 452F, 453T, 454T, 455I, 456M, 479Q, 480E, 481T, 482K, 483L, 484V, 485E, 486Y, 487Q, 488T, 489N
CDD
cd00186 (TOP1Ac)431Idomain II
236S, 237E, 238P, 239Y, 240W, 241V, 242V, 243Q, 281Q, 282S, 283Q, 284V, 285T, 286K, 287I, 288T, 289R, 290K, 291E, 292K, 293A, 294K, 295S, 422K, 423D, 424C, 425K, 426Y, 427L, 428S, 429T, 430T, 431I, 432T, 433F, 434L, 435I, 436N, 438E, 439I, 440F, 441T, 442A, 443T, 444G, 445K, 446T, 447L, 448I, 449D, 450P, 451G, 452F, 453T, 454T, 455I, 456M, 479Q, 480E, 481T, 482K, 483L, 484V, 485E, 486Y, 487Q, 488T, 489N
CDD
cd00186 (TOP1Ac)432Tdomain II
236S, 237E, 238P, 239Y, 240W, 241V, 242V, 243Q, 281Q, 282S, 283Q, 284V, 285T, 286K, 287I, 288T, 289R, 290K, 291E, 292K, 293A, 294K, 295S, 422K, 423D, 424C, 425K, 426Y, 427L, 428S, 429T, 430T, 431I, 432T, 433F, 434L, 435I, 436N, 438E, 439I, 440F, 441T, 442A, 443T, 444G, 445K, 446T, 447L, 448I, 449D, 450P, 451G, 452F, 453T, 454T, 455I, 456M, 479Q, 480E, 481T, 482K, 483L, 484V, 485E, 486Y, 487Q, 488T, 489N
CDD
cd00186 (TOP1Ac)433Fdomain II
236S, 237E, 238P, 239Y, 240W, 241V, 242V, 243Q, 281Q, 282S, 283Q, 284V, 285T, 286K, 287I, 288T, 289R, 290K, 291E, 292K, 293A, 294K, 295S, 422K, 423D, 424C, 425K, 426Y, 427L, 428S, 429T, 430T, 431I, 432T, 433F, 434L, 435I, 436N, 438E, 439I, 440F, 441T, 442A, 443T, 444G, 445K, 446T, 447L, 448I, 449D, 450P, 451G, 452F, 453T, 454T, 455I, 456M, 479Q, 480E, 481T, 482K, 483L, 484V, 485E, 486Y, 487Q, 488T, 489N
CDD
cd00186 (TOP1Ac)434Ldomain II
236S, 237E, 238P, 239Y, 240W, 241V, 242V, 243Q, 281Q, 282S, 283Q, 284V, 285T, 286K, 287I, 288T, 289R, 290K, 291E, 292K, 293A, 294K, 295S, 422K, 423D, 424C, 425K, 426Y, 427L, 428S, 429T, 430T, 431I, 432T, 433F, 434L, 435I, 436N, 438E, 439I, 440F, 441T, 442A, 443T, 444G, 445K, 446T, 447L, 448I, 449D, 450P, 451G, 452F, 453T, 454T, 455I, 456M, 479Q, 480E, 481T, 482K, 483L, 484V, 485E, 486Y, 487Q, 488T, 489N
CDD
cd00186 (TOP1Ac)435Idomain II
236S, 237E, 238P, 239Y, 240W, 241V, 242V, 243Q, 281Q, 282S, 283Q, 284V, 285T, 286K, 287I, 288T, 289R, 290K, 291E, 292K, 293A, 294K, 295S, 422K, 423D, 424C, 425K, 426Y, 427L, 428S, 429T, 430T, 431I, 432T, 433F, 434L, 435I, 436N, 438E, 439I, 440F, 441T, 442A, 443T, 444G, 445K, 446T, 447L, 448I, 449D, 450P, 451G, 452F, 453T, 454T, 455I, 456M, 479Q, 480E, 481T, 482K, 483L, 484V, 485E, 486Y, 487Q, 488T, 489N
CDD
cd00186 (TOP1Ac)436Ndomain II
236S, 237E, 238P, 239Y, 240W, 241V, 242V, 243Q, 281Q, 282S, 283Q, 284V, 285T, 286K, 287I, 288T, 289R, 290K, 291E, 292K, 293A, 294K, 295S, 422K, 423D, 424C, 425K, 426Y, 427L, 428S, 429T, 430T, 431I, 432T, 433F, 434L, 435I, 436N, 438E, 439I, 440F, 441T, 442A, 443T, 444G, 445K, 446T, 447L, 448I, 449D, 450P, 451G, 452F, 453T, 454T, 455I, 456M, 479Q, 480E, 481T, 482K, 483L, 484V, 485E, 486Y, 487Q, 488T, 489N
CDD
cd00186 (TOP1Ac)438Edomain II
236S, 237E, 238P, 239Y, 240W, 241V, 242V, 243Q, 281Q, 282S, 283Q, 284V, 285T, 286K, 287I, 288T, 289R, 290K, 291E, 292K, 293A, 294K, 295S, 422K, 423D, 424C, 425K, 426Y, 427L, 428S, 429T, 430T, 431I, 432T, 433F, 434L, 435I, 436N, 438E, 439I, 440F, 441T, 442A, 443T, 444G, 445K, 446T, 447L, 448I, 449D, 450P, 451G, 452F, 453T, 454T, 455I, 456M, 479Q, 480E, 481T, 482K, 483L, 484V, 485E, 486Y, 487Q, 488T, 489N
CDD
cd00186 (TOP1Ac)439Idomain II
236S, 237E, 238P, 239Y, 240W, 241V, 242V, 243Q, 281Q, 282S, 283Q, 284V, 285T, 286K, 287I, 288T, 289R, 290K, 291E, 292K, 293A, 294K, 295S, 422K, 423D, 424C, 425K, 426Y, 427L, 428S, 429T, 430T, 431I, 432T, 433F, 434L, 435I, 436N, 438E, 439I, 440F, 441T, 442A, 443T, 444G, 445K, 446T, 447L, 448I, 449D, 450P, 451G, 452F, 453T, 454T, 455I, 456M, 479Q, 480E, 481T, 482K, 483L, 484V, 485E, 486Y, 487Q, 488T, 489N
CDD
cd00186 (TOP1Ac)440Fdomain II
236S, 237E, 238P, 239Y, 240W, 241V, 242V, 243Q, 281Q, 282S, 283Q, 284V, 285T, 286K, 287I, 288T, 289R, 290K, 291E, 292K, 293A, 294K, 295S, 422K, 423D, 424C, 425K, 426Y, 427L, 428S, 429T, 430T, 431I, 432T, 433F, 434L, 435I, 436N, 438E, 439I, 440F, 441T, 442A, 443T, 444G, 445K, 446T, 447L, 448I, 449D, 450P, 451G, 452F, 453T, 454T, 455I, 456M, 479Q, 480E, 481T, 482K, 483L, 484V, 485E, 486Y, 487Q, 488T, 489N
CDD
cd00186 (TOP1Ac)441Tdomain II
236S, 237E, 238P, 239Y, 240W, 241V, 242V, 243Q, 281Q, 282S, 283Q, 284V, 285T, 286K, 287I, 288T, 289R, 290K, 291E, 292K, 293A, 294K, 295S, 422K, 423D, 424C, 425K, 426Y, 427L, 428S, 429T, 430T, 431I, 432T, 433F, 434L, 435I, 436N, 438E, 439I, 440F, 441T, 442A, 443T, 444G, 445K, 446T, 447L, 448I, 449D, 450P, 451G, 452F, 453T, 454T, 455I, 456M, 479Q, 480E, 481T, 482K, 483L, 484V, 485E, 486Y, 487Q, 488T, 489N
CDD
cd00186 (TOP1Ac)442Adomain II
236S, 237E, 238P, 239Y, 240W, 241V, 242V, 243Q, 281Q, 282S, 283Q, 284V, 285T, 286K, 287I, 288T, 289R, 290K, 291E, 292K, 293A, 294K, 295S, 422K, 423D, 424C, 425K, 426Y, 427L, 428S, 429T, 430T, 431I, 432T, 433F, 434L, 435I, 436N, 438E, 439I, 440F, 441T, 442A, 443T, 444G, 445K, 446T, 447L, 448I, 449D, 450P, 451G, 452F, 453T, 454T, 455I, 456M, 479Q, 480E, 481T, 482K, 483L, 484V, 485E, 486Y, 487Q, 488T, 489N
CDD
cd00186 (TOP1Ac)443Tdomain II
236S, 237E, 238P, 239Y, 240W, 241V, 242V, 243Q, 281Q, 282S, 283Q, 284V, 285T, 286K, 287I, 288T, 289R, 290K, 291E, 292K, 293A, 294K, 295S, 422K, 423D, 424C, 425K, 426Y, 427L, 428S, 429T, 430T, 431I, 432T, 433F, 434L, 435I, 436N, 438E, 439I, 440F, 441T, 442A, 443T, 444G, 445K, 446T, 447L, 448I, 449D, 450P, 451G, 452F, 453T, 454T, 455I, 456M, 479Q, 480E, 481T, 482K, 483L, 484V, 485E, 486Y, 487Q, 488T, 489N
CDD
cd00186 (TOP1Ac)444Gdomain II
236S, 237E, 238P, 239Y, 240W, 241V, 242V, 243Q, 281Q, 282S, 283Q, 284V, 285T, 286K, 287I, 288T, 289R, 290K, 291E, 292K, 293A, 294K, 295S, 422K, 423D, 424C, 425K, 426Y, 427L, 428S, 429T, 430T, 431I, 432T, 433F, 434L, 435I, 436N, 438E, 439I, 440F, 441T, 442A, 443T, 444G, 445K, 446T, 447L, 448I, 449D, 450P, 451G, 452F, 453T, 454T, 455I, 456M, 479Q, 480E, 481T, 482K, 483L, 484V, 485E, 486Y, 487Q, 488T, 489N
CDD
cd00186 (TOP1Ac)445Kdomain II
236S, 237E, 238P, 239Y, 240W, 241V, 242V, 243Q, 281Q, 282S, 283Q, 284V, 285T, 286K, 287I, 288T, 289R, 290K, 291E, 292K, 293A, 294K, 295S, 422K, 423D, 424C, 425K, 426Y, 427L, 428S, 429T, 430T, 431I, 432T, 433F, 434L, 435I, 436N, 438E, 439I, 440F, 441T, 442A, 443T, 444G, 445K, 446T, 447L, 448I, 449D, 450P, 451G, 452F, 453T, 454T, 455I, 456M, 479Q, 480E, 481T, 482K, 483L, 484V, 485E, 486Y, 487Q, 488T, 489N
CDD
cd00186 (TOP1Ac)446Tdomain II
236S, 237E, 238P, 239Y, 240W, 241V, 242V, 243Q, 281Q, 282S, 283Q, 284V, 285T, 286K, 287I, 288T, 289R, 290K, 291E, 292K, 293A, 294K, 295S, 422K, 423D, 424C, 425K, 426Y, 427L, 428S, 429T, 430T, 431I, 432T, 433F, 434L, 435I, 436N, 438E, 439I, 440F, 441T, 442A, 443T, 444G, 445K, 446T, 447L, 448I, 449D, 450P, 451G, 452F, 453T, 454T, 455I, 456M, 479Q, 480E, 481T, 482K, 483L, 484V, 485E, 486Y, 487Q, 488T, 489N
CDD
cd00186 (TOP1Ac)447Ldomain II
236S, 237E, 238P, 239Y, 240W, 241V, 242V, 243Q, 281Q, 282S, 283Q, 284V, 285T, 286K, 287I, 288T, 289R, 290K, 291E, 292K, 293A, 294K, 295S, 422K, 423D, 424C, 425K, 426Y, 427L, 428S, 429T, 430T, 431I, 432T, 433F, 434L, 435I, 436N, 438E, 439I, 440F, 441T, 442A, 443T, 444G, 445K, 446T, 447L, 448I, 449D, 450P, 451G, 452F, 453T, 454T, 455I, 456M, 479Q, 480E, 481T, 482K, 483L, 484V, 485E, 486Y, 487Q, 488T, 489N
CDD
cd00186 (TOP1Ac)448Idomain II
236S, 237E, 238P, 239Y, 240W, 241V, 242V, 243Q, 281Q, 282S, 283Q, 284V, 285T, 286K, 287I, 288T, 289R, 290K, 291E, 292K, 293A, 294K, 295S, 422K, 423D, 424C, 425K, 426Y, 427L, 428S, 429T, 430T, 431I, 432T, 433F, 434L, 435I, 436N, 438E, 439I, 440F, 441T, 442A, 443T, 444G, 445K, 446T, 447L, 448I, 449D, 450P, 451G, 452F, 453T, 454T, 455I, 456M, 479Q, 480E, 481T, 482K, 483L, 484V, 485E, 486Y, 487Q, 488T, 489N
CDD
cd00186 (TOP1Ac)449Ddomain II
236S, 237E, 238P, 239Y, 240W, 241V, 242V, 243Q, 281Q, 282S, 283Q, 284V, 285T, 286K, 287I, 288T, 289R, 290K, 291E, 292K, 293A, 294K, 295S, 422K, 423D, 424C, 425K, 426Y, 427L, 428S, 429T, 430T, 431I, 432T, 433F, 434L, 435I, 436N, 438E, 439I, 440F, 441T, 442A, 443T, 444G, 445K, 446T, 447L, 448I, 449D, 450P, 451G, 452F, 453T, 454T, 455I, 456M, 479Q, 480E, 481T, 482K, 483L, 484V, 485E, 486Y, 487Q, 488T, 489N
CDD
cd00186 (TOP1Ac)450Pdomain II
236S, 237E, 238P, 239Y, 240W, 241V, 242V, 243Q, 281Q, 282S, 283Q, 284V, 285T, 286K, 287I, 288T, 289R, 290K, 291E, 292K, 293A, 294K, 295S, 422K, 423D, 424C, 425K, 426Y, 427L, 428S, 429T, 430T, 431I, 432T, 433F, 434L, 435I, 436N, 438E, 439I, 440F, 441T, 442A, 443T, 444G, 445K, 446T, 447L, 448I, 449D, 450P, 451G, 452F, 453T, 454T, 455I, 456M, 479Q, 480E, 481T, 482K, 483L, 484V, 485E, 486Y, 487Q, 488T, 489N
CDD
cd00186 (TOP1Ac)451Gdomain II
236S, 237E, 238P, 239Y, 240W, 241V, 242V, 243Q, 281Q, 282S, 283Q, 284V, 285T, 286K, 287I, 288T, 289R, 290K, 291E, 292K, 293A, 294K, 295S, 422K, 423D, 424C, 425K, 426Y, 427L, 428S, 429T, 430T, 431I, 432T, 433F, 434L, 435I, 436N, 438E, 439I, 440F, 441T, 442A, 443T, 444G, 445K, 446T, 447L, 448I, 449D, 450P, 451G, 452F, 453T, 454T, 455I, 456M, 479Q, 480E, 481T, 482K, 483L, 484V, 485E, 486Y, 487Q, 488T, 489N
CDD
cd00186 (TOP1Ac)452Fdomain II
236S, 237E, 238P, 239Y, 240W, 241V, 242V, 243Q, 281Q, 282S, 283Q, 284V, 285T, 286K, 287I, 288T, 289R, 290K, 291E, 292K, 293A, 294K, 295S, 422K, 423D, 424C, 425K, 426Y, 427L, 428S, 429T, 430T, 431I, 432T, 433F, 434L, 435I, 436N, 438E, 439I, 440F, 441T, 442A, 443T, 444G, 445K, 446T, 447L, 448I, 449D, 450P, 451G, 452F, 453T, 454T, 455I, 456M, 479Q, 480E, 481T, 482K, 483L, 484V, 485E, 486Y, 487Q, 488T, 489N
CDD
cd00186 (TOP1Ac)453Tdomain II
236S, 237E, 238P, 239Y, 240W, 241V, 242V, 243Q, 281Q, 282S, 283Q, 284V, 285T, 286K, 287I, 288T, 289R, 290K, 291E, 292K, 293A, 294K, 295S, 422K, 423D, 424C, 425K, 426Y, 427L, 428S, 429T, 430T, 431I, 432T, 433F, 434L, 435I, 436N, 438E, 439I, 440F, 441T, 442A, 443T, 444G, 445K, 446T, 447L, 448I, 449D, 450P, 451G, 452F, 453T, 454T, 455I, 456M, 479Q, 480E, 481T, 482K, 483L, 484V, 485E, 486Y, 487Q, 488T, 489N
CDD
cd00186 (TOP1Ac)454Tdomain II
236S, 237E, 238P, 239Y, 240W, 241V, 242V, 243Q, 281Q, 282S, 283Q, 284V, 285T, 286K, 287I, 288T, 289R, 290K, 291E, 292K, 293A, 294K, 295S, 422K, 423D, 424C, 425K, 426Y, 427L, 428S, 429T, 430T, 431I, 432T, 433F, 434L, 435I, 436N, 438E, 439I, 440F, 441T, 442A, 443T, 444G, 445K, 446T, 447L, 448I, 449D, 450P, 451G, 452F, 453T, 454T, 455I, 456M, 479Q, 480E, 481T, 482K, 483L, 484V, 485E, 486Y, 487Q, 488T, 489N
CDD
cd00186 (TOP1Ac)455Idomain II
236S, 237E, 238P, 239Y, 240W, 241V, 242V, 243Q, 281Q, 282S, 283Q, 284V, 285T, 286K, 287I, 288T, 289R, 290K, 291E, 292K, 293A, 294K, 295S, 422K, 423D, 424C, 425K, 426Y, 427L, 428S, 429T, 430T, 431I, 432T, 433F, 434L, 435I, 436N, 438E, 439I, 440F, 441T, 442A, 443T, 444G, 445K, 446T, 447L, 448I, 449D, 450P, 451G, 452F, 453T, 454T, 455I, 456M, 479Q, 480E, 481T, 482K, 483L, 484V, 485E, 486Y, 487Q, 488T, 489N
CDD
cd00186 (TOP1Ac)456Mdomain II
236S, 237E, 238P, 239Y, 240W, 241V, 242V, 243Q, 281Q, 282S, 283Q, 284V, 285T, 286K, 287I, 288T, 289R, 290K, 291E, 292K, 293A, 294K, 295S, 422K, 423D, 424C, 425K, 426Y, 427L, 428S, 429T, 430T, 431I, 432T, 433F, 434L, 435I, 436N, 438E, 439I, 440F, 441T, 442A, 443T, 444G, 445K, 446T, 447L, 448I, 449D, 450P, 451G, 452F, 453T, 454T, 455I, 456M, 479Q, 480E, 481T, 482K, 483L, 484V, 485E, 486Y, 487Q, 488T, 489N
CDD
cd00186 (TOP1Ac)479Qdomain II
236S, 237E, 238P, 239Y, 240W, 241V, 242V, 243Q, 281Q, 282S, 283Q, 284V, 285T, 286K, 287I, 288T, 289R, 290K, 291E, 292K, 293A, 294K, 295S, 422K, 423D, 424C, 425K, 426Y, 427L, 428S, 429T, 430T, 431I, 432T, 433F, 434L, 435I, 436N, 438E, 439I, 440F, 441T, 442A, 443T, 444G, 445K, 446T, 447L, 448I, 449D, 450P, 451G, 452F, 453T, 454T, 455I, 456M, 479Q, 480E, 481T, 482K, 483L, 484V, 485E, 486Y, 487Q, 488T, 489N
CDD
cd00186 (TOP1Ac)480Edomain II
236S, 237E, 238P, 239Y, 240W, 241V, 242V, 243Q, 281Q, 282S, 283Q, 284V, 285T, 286K, 287I, 288T, 289R, 290K, 291E, 292K, 293A, 294K, 295S, 422K, 423D, 424C, 425K, 426Y, 427L, 428S, 429T, 430T, 431I, 432T, 433F, 434L, 435I, 436N, 438E, 439I, 440F, 441T, 442A, 443T, 444G, 445K, 446T, 447L, 448I, 449D, 450P, 451G, 452F, 453T, 454T, 455I, 456M, 479Q, 480E, 481T, 482K, 483L, 484V, 485E, 486Y, 487Q, 488T, 489N
CDD
cd00186 (TOP1Ac)481Tdomain II
236S, 237E, 238P, 239Y, 240W, 241V, 242V, 243Q, 281Q, 282S, 283Q, 284V, 285T, 286K, 287I, 288T, 289R, 290K, 291E, 292K, 293A, 294K, 295S, 422K, 423D, 424C, 425K, 426Y, 427L, 428S, 429T, 430T, 431I, 432T, 433F, 434L, 435I, 436N, 438E, 439I, 440F, 441T, 442A, 443T, 444G, 445K, 446T, 447L, 448I, 449D, 450P, 451G, 452F, 453T, 454T, 455I, 456M, 479Q, 480E, 481T, 482K, 483L, 484V, 485E, 486Y, 487Q, 488T, 489N
CDD
cd00186 (TOP1Ac)482Kdomain II
236S, 237E, 238P, 239Y, 240W, 241V, 242V, 243Q, 281Q, 282S, 283Q, 284V, 285T, 286K, 287I, 288T, 289R, 290K, 291E, 292K, 293A, 294K, 295S, 422K, 423D, 424C, 425K, 426Y, 427L, 428S, 429T, 430T, 431I, 432T, 433F, 434L, 435I, 436N, 438E, 439I, 440F, 441T, 442A, 443T, 444G, 445K, 446T, 447L, 448I, 449D, 450P, 451G, 452F, 453T, 454T, 455I, 456M, 479Q, 480E, 481T, 482K, 483L, 484V, 485E, 486Y, 487Q, 488T, 489N
CDD
cd00186 (TOP1Ac)483Ldomain II
236S, 237E, 238P, 239Y, 240W, 241V, 242V, 243Q, 281Q, 282S, 283Q, 284V, 285T, 286K, 287I, 288T, 289R, 290K, 291E, 292K, 293A, 294K, 295S, 422K, 423D, 424C, 425K, 426Y, 427L, 428S, 429T, 430T, 431I, 432T, 433F, 434L, 435I, 436N, 438E, 439I, 440F, 441T, 442A, 443T, 444G, 445K, 446T, 447L, 448I, 449D, 450P, 451G, 452F, 453T, 454T, 455I, 456M, 479Q, 480E, 481T, 482K, 483L, 484V, 485E, 486Y, 487Q, 488T, 489N
CDD
cd00186 (TOP1Ac)484Vdomain II
236S, 237E, 238P, 239Y, 240W, 241V, 242V, 243Q, 281Q, 282S, 283Q, 284V, 285T, 286K, 287I, 288T, 289R, 290K, 291E, 292K, 293A, 294K, 295S, 422K, 423D, 424C, 425K, 426Y, 427L, 428S, 429T, 430T, 431I, 432T, 433F, 434L, 435I, 436N, 438E, 439I, 440F, 441T, 442A, 443T, 444G, 445K, 446T, 447L, 448I, 449D, 450P, 451G, 452F, 453T, 454T, 455I, 456M, 479Q, 480E, 481T, 482K, 483L, 484V, 485E, 486Y, 487Q, 488T, 489N
CDD
cd00186 (TOP1Ac)485Edomain II
236S, 237E, 238P, 239Y, 240W, 241V, 242V, 243Q, 281Q, 282S, 283Q, 284V, 285T, 286K, 287I, 288T, 289R, 290K, 291E, 292K, 293A, 294K, 295S, 422K, 423D, 424C, 425K, 426Y, 427L, 428S, 429T, 430T, 431I, 432T, 433F, 434L, 435I, 436N, 438E, 439I, 440F, 441T, 442A, 443T, 444G, 445K, 446T, 447L, 448I, 449D, 450P, 451G, 452F, 453T, 454T, 455I, 456M, 479Q, 480E, 481T, 482K, 483L, 484V, 485E, 486Y, 487Q, 488T, 489N
CDD
cd00186 (TOP1Ac)486Ydomain II
236S, 237E, 238P, 239Y, 240W, 241V, 242V, 243Q, 281Q, 282S, 283Q, 284V, 285T, 286K, 287I, 288T, 289R, 290K, 291E, 292K, 293A, 294K, 295S, 422K, 423D, 424C, 425K, 426Y, 427L, 428S, 429T, 430T, 431I, 432T, 433F, 434L, 435I, 436N, 438E, 439I, 440F, 441T, 442A, 443T, 444G, 445K, 446T, 447L, 448I, 449D, 450P, 451G, 452F, 453T, 454T, 455I, 456M, 479Q, 480E, 481T, 482K, 483L, 484V, 485E, 486Y, 487Q, 488T, 489N
CDD
cd00186 (TOP1Ac)487Qdomain II
236S, 237E, 238P, 239Y, 240W, 241V, 242V, 243Q, 281Q, 282S, 283Q, 284V, 285T, 286K, 287I, 288T, 289R, 290K, 291E, 292K, 293A, 294K, 295S, 422K, 423D, 424C, 425K, 426Y, 427L, 428S, 429T, 430T, 431I, 432T, 433F, 434L, 435I, 436N, 438E, 439I, 440F, 441T, 442A, 443T, 444G, 445K, 446T, 447L, 448I, 449D, 450P, 451G, 452F, 453T, 454T, 455I, 456M, 479Q, 480E, 481T, 482K, 483L, 484V, 485E, 486Y, 487Q, 488T, 489N
CDD
cd00186 (TOP1Ac)488Tdomain II
236S, 237E, 238P, 239Y, 240W, 241V, 242V, 243Q, 281Q, 282S, 283Q, 284V, 285T, 286K, 287I, 288T, 289R, 290K, 291E, 292K, 293A, 294K, 295S, 422K, 423D, 424C, 425K, 426Y, 427L, 428S, 429T, 430T, 431I, 432T, 433F, 434L, 435I, 436N, 438E, 439I, 440F, 441T, 442A, 443T, 444G, 445K, 446T, 447L, 448I, 449D, 450P, 451G, 452F, 453T, 454T, 455I, 456M, 479Q, 480E, 481T, 482K, 483L, 484V, 485E, 486Y, 487Q, 488T, 489N
CDD
cd00186 (TOP1Ac)489Ndomain II
236S, 237E, 238P, 239Y, 240W, 241V, 242V, 243Q, 281Q, 282S, 283Q, 284V, 285T, 286K, 287I, 288T, 289R, 290K, 291E, 292K, 293A, 294K, 295S, 422K, 423D, 424C, 425K, 426Y, 427L, 428S, 429T, 430T, 431I, 432T, 433F, 434L, 435I, 436N, 438E, 439I, 440F, 441T, 442A, 443T, 444G, 445K, 446T, 447L, 448I, 449D, 450P, 451G, 452F, 453T, 454T, 455I, 456M, 479Q, 480E, 481T, 482K, 483L, 484V, 485E, 486Y, 487Q, 488T, 489N
CDD
cd00186 (TOP1Ac) -
domain III cd00186296Rdomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)297Pdomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)298Ldomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)299Adomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)300Ldomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)301Ndomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)302Tdomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)304Edomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)305Ldomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)306Mdomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)307Rdomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)308Vdomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)309Adomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)310Sdomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)311Sdomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)312Gdomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)313Ldomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)314Gdomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)315Mdomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)316Gdomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)317Pdomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)318Hdomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)319Hdomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)320Adomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)321Mdomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)322Qdomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)323Idomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)324Adomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)325Edomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)326Kdomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)327Ldomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)328Ydomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)329Tdomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)330Qdomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)331Gdomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)332Ydomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)333Idomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)334Sdomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)335Ydomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)336Pdomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)337Rdomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)338Tdomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)339Edomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)340Tdomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)341Tdomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)342Rdomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)343Ydomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)344Pdomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)345Edomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)346Ndomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)347Fdomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)348Ddomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)350Fdomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)351Rdomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)352Gdomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)353Vdomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)354Ldomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)355Kdomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)356Qdomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)357Qdomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)358Qdomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)359Ndomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)360Ndomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)386Ddomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)387Hdomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)388Pdomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)389Pdomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)390Idomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)391Tdomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)392Pdomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)393Mdomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)394Kdomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)401Ldomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)402Ddomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)403Gdomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)404Ddomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)405Sdomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)406Wdomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)407Kdomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)408Ldomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)409Ydomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)410Ddomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)411Ydomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)412Idomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)413Tdomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)414Rdomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)415Hdomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)416Fdomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)417Idomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)418Adomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)419Tdomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)420Vdomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac)421Sdomain III
296R, 297P, 298L, 299A, 300L, 301N, 302T, 304E, 305L, 306M, 307R, 308V, 309A, 310S, 311S, 312G, 313L, 314G, 315M, 316G, 317P, 318H, 319H, 320A, 321M, 322Q, 323I, 324A, 325E, 326K, 327L, 328Y, 329T, 330Q, 331G, 332Y, 333I, 334S, 335Y, 336P, 337R, 338T, 339E, 340T, 341T, 342R, 343Y, 344P, 345E, 346N, 347F, 348D, 350F, 351R, 352G, 353V, 354L, 355K, 356Q, 357Q, 358Q, 359N, 360N, 386D, 387H, 388P, 389P, 390I, 391T, 392P, 393M, 394K, 401L, 402D, 403G, 404D, 405S, 406W, 407K, 408L, 409Y, 410D, 411Y, 412I, 413T, 414R, 415H, 416F, 417I, 418A, 419T, 420V, 421S
CDD
cd00186 (TOP1Ac) -
nucleotide binding...307Rnucleotide binding site
307R, 311S, 312G, 313L, 387H, 407K, 410D, 414R, 510T, 512A, 535L
CDD
cd00186 (TOP1Ac)311Snucleotide binding site
307R, 311S, 312G, 313L, 387H, 407K, 410D, 414R, 510T, 512A, 535L
CDD
cd00186 (TOP1Ac)312Gnucleotide binding site
307R, 311S, 312G, 313L, 387H, 407K, 410D, 414R, 510T, 512A, 535L
CDD
cd00186 (TOP1Ac)313Lnucleotide binding site
307R, 311S, 312G, 313L, 387H, 407K, 410D, 414R, 510T, 512A, 535L
CDD
cd00186 (TOP1Ac)387Hnucleotide binding site
307R, 311S, 312G, 313L, 387H, 407K, 410D, 414R, 510T, 512A, 535L
CDD
cd00186 (TOP1Ac)407Knucleotide binding site
307R, 311S, 312G, 313L, 387H, 407K, 410D, 414R, 510T, 512A, 535L
CDD
cd00186 (TOP1Ac)410Dnucleotide binding site
307R, 311S, 312G, 313L, 387H, 407K, 410D, 414R, 510T, 512A, 535L
CDD
cd00186 (TOP1Ac)414Rnucleotide binding site
307R, 311S, 312G, 313L, 387H, 407K, 410D, 414R, 510T, 512A, 535L
CDD
cd00186 (TOP1Ac)510Tnucleotide binding site
307R, 311S, 312G, 313L, 387H, 407K, 410D, 414R, 510T, 512A, 535L
CDD
cd00186 (TOP1Ac)512Anucleotide binding site
307R, 311S, 312G, 313L, 387H, 407K, 410D, 414R, 510T, 512A, 535L
CDD
cd00186 (TOP1Ac)535Lnucleotide binding site
307R, 311S, 312G, 313L, 387H, 407K, 410D, 414R, 510T, 512A, 535L
CDD
cd00186 (TOP1Ac) -
catalytic site cd0...
-
domain IV cd00186490Pdomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)491Pdomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)492Ddomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)493Ydomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)494Ldomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)495Tdomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)496Edomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)497Sdomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)498Edomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)499Ldomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)500Idomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)501Tdomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)502Ldomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)503Mdomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)504Edomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)505Kdomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)506Hdomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)507Gdomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)508Idomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)509Gdomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)510Tdomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)511Ddomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)512Adomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)513Sdomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)514Idomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)515Pdomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)516Vdomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)517Hdomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)518Idomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)519Ndomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)520Ndomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)521Idomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)522Cdomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)523Qdomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)524Rdomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)525Ndomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)526Ydomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)527Vdomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)528Tdomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)529Vdomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)531Gdomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)535Ldomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)536Idomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)537Pdomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)538Tdomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)539Tdomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)540Ldomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)541Gdomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)542Idomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)543Vdomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)544Ldomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)545Vdomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)546Hdomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)547Gdomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)548Ydomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)549Qdomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)555Ldomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)556Vdomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)557Ldomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)558Pdomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)559Tdomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)560Mdomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)561Rdomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)562Sdomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)563Adomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)564Vdomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)565Edomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)566Edomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)567Qdomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)568Ldomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)569Ndomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)570Ldomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)571Idomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)572Adomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)573Ldomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)574Gdomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)575Kdomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)576Adomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)577Ndomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)578Fdomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)579Qdomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)580Adomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)581Vdomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)582Ldomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)583Kdomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)584Hdomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)585Tdomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)586Vdomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)587Edomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)588Idomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)589Fdomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)590Ndomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)591Ldomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)592Kdomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)593Fdomain IV
490P, 491P, 492D, 493Y, 494L, 495T, 496E, 497S, 498E, 499L, 500I, 501T, 502L, 503M, 504E, 505K, 506H, 507G, 508I, 509G, 510T, 511D, 512A, 513S, 514I, 515P, 516V, 517H, 518I, 519N, 520N, 521I, 522C, 523Q, 524R, 525N, 526Y, 527V, 528T, 529V, 531G, 535L, 536I, 537P, 538T, 539T, 540L, 541G, 542I, 543V, 544L, 545V, 546H, 547G, 548Y, 549Q, 555L, 556V, 557L, 558P, 559T, 560M, 561R, 562S, 563A, 564V, 565E, 566E, 567Q, 568L, 569N, 570L, 571I, 572A, 573L, 574G, 575K, 576A, 577N, 578F, 579Q, 580A, 581V, 582L, 583K, 584H, 585T, 586V, 587E, 588I, 589F, 590N, 591L, 592K, 593F
CDD
cd00186 (TOP1Ac)
GO term prediction
Biological Process
GO:0006265 DNA topological change
Molecular Function
GO:0003677 DNA binding
GO:0003916 DNA topoisomerase activity
GO:0003917 DNA topoisomerase type I (single strand cut, ATP-independent) activity
Cellular Component
None predicted.