<?xml version="1.0" encoding="UTF-8"?><protein-matches xmlns="http://www.ebi.ac.uk/interpro/resources/schemas/interproscan5" interproscan-version="5.54-87.0">
  <protein>
    <sequence md5="927360efdc64ec6774be0b89f8c3bffb">MPISKVKYARLTNIGDPKDAAFDFTSAFSYNEEGGGEYAKHDFGSAFKYRDPCVKVRIDDEGALNHTAKPSLFLTATSWTLTVLSYFFFLVTIPVSYWFFVKKMGEFERLVIFRLGKMIGVKGPGRFVVFPWMDRIKRIDVRASAFSVPPQQFITVDGGIVEMGAEIQYGIVDVVTMISEVADHQDILRSLGKTLLIKILVKKTVTQLQRDKRMGAQEIMDEINDQVRKWGINVQSVTLSEPKILKQADSGSNTAVSSIMKGLGVKGESKYPSPQEFVRVSHGLEEPQQDTFSATSLLGATGLGGGGGAGAGGVGGGGPSATMNMSMLQSLTQGGSVSSNMGMVSQPTETKVEELPANWGRCLEVIINNEFGLIEDDAHGVYELEITDTESGKDVYFIELSVEKRSVSTENTSGKRPDVSVSISSPDLGNVLDGSLAPLQAYLTGRITANGDVRKLMFFDKLSRRGHKPGSMFNV</sequence>
    <xref id="TCALIF_00406-PA" name="TCALIF_00406-PA protein Name:&quot;Similar to STOML1 Stomatin-like protein 1 (Homo sapiens)&quot; AED:0.23 eAED:0.26 QI:0|-1|0|1|-1|1|1|0|475"/>
    <matches>
      <fingerprints-match evalue="6.8E-10" graphscan="Iiii...">
        <signature ac="PR00721" desc="Stomatin signature" name="STOMATIN">
          <entry ac="IPR001972" desc="Stomatin/HflK/HflC family" name="Stomatin_HflK_HflKC_fam" type="FAMILY">
            <go-xref category="CELLULAR_COMPONENT" db="GO" id="GO:0016020" name="membrane"/>
            <pathway-xref db="Reactome" id="R-HSA-8949664" name="Processing of SMDT1"/>
            <pathway-xref db="Reactome" id="R-MMU-9013026" name="RHOB GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-CEL-9013406" name="RHOQ GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-8949664" name="Processing of SMDT1"/>
            <pathway-xref db="Reactome" id="R-DME-9013407" name="RHOH GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-9013407" name="RHOH GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-9013406" name="RHOQ GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-CEL-2672351" name="Stimuli-sensing channels"/>
            <pathway-xref db="Reactome" id="R-HSA-9013406" name="RHOQ GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DME-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-HSA-9013407" name="RHOH GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-8949664" name="Processing of SMDT1"/>
            <pathway-xref db="Reactome" id="R-DME-2672351" name="Stimuli-sensing channels"/>
            <pathway-xref db="Reactome" id="R-MMU-9013106" name="RHOC GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-373753" name="Nephrin family interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-9013409" name="RHOJ GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-CEL-9013407" name="RHOH GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-CEL-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-MMU-2672351" name="Stimuli-sensing channels"/>
            <pathway-xref db="Reactome" id="R-CEL-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-9013148" name="CDC42 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-2672351" name="Stimuli-sensing channels"/>
            <pathway-xref db="Reactome" id="R-DME-9013406" name="RHOQ GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-RNO-373753" name="Nephrin family interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-9013026" name="RHOB GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-9013148" name="CDC42 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DME-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-373753" name="Nephrin family interactions"/>
            <pathway-xref db="Reactome" id="R-DME-373753" name="Nephrin family interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-9013106" name="RHOC GTPase cycle"/>
          </entry>
          <signature-library-release library="PRINTS" version="42.0"/>
        </signature>
        <model-ac>PR00721</model-ac>
        <locations>
          <fingerprints-location motifNumber="1" pvalue="1.25E-10" score="45.65" start="106" end="128">
            <location-fragments>
              <fingerprints-location-fragment start="106" end="128" dc-status="CONTINUOUS"/>
            </location-fragments>
          </fingerprints-location>
          <fingerprints-location motifNumber="3" pvalue="0.0344" score="25.79" start="188" end="205">
            <location-fragments>
              <fingerprints-location-fragment start="188" end="205" dc-status="CONTINUOUS"/>
            </location-fragments>
          </fingerprints-location>
          <fingerprints-location motifNumber="2" pvalue="0.00936" score="22.4" start="153" end="174">
            <location-fragments>
              <fingerprints-location-fragment start="153" end="174" dc-status="CONTINUOUS"/>
            </location-fragments>
          </fingerprints-location>
          <fingerprints-location motifNumber="4" pvalue="0.0174" score="18.15" start="208" end="231">
            <location-fragments>
              <fingerprints-location-fragment start="208" end="231" dc-status="CONTINUOUS"/>
            </location-fragments>
          </fingerprints-location>
        </locations>
      </fingerprints-match>
      <hmmer2-match evalue="1.1E-15" score="68.1">
        <signature ac="SM00244" name="PHB_4">
          <entry ac="IPR001107" desc="Band 7 domain" name="Band_7" type="DOMAIN">
            <pathway-xref db="Reactome" id="R-DRE-9696264" name="RND3 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-BTA-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-5673000" name="RAF activation"/>
            <pathway-xref db="Reactome" id="R-MMU-382556" name="ABC-family proteins mediated transport"/>
            <pathway-xref db="Reactome" id="R-HSA-8949664" name="Processing of SMDT1"/>
            <pathway-xref db="Reactome" id="R-MMU-9013026" name="RHOB GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-CEL-382556" name="ABC-family proteins mediated transport"/>
            <pathway-xref db="Reactome" id="R-SSC-8849932" name="Synaptic adhesion-like molecules"/>
            <pathway-xref db="Reactome" id="R-BTA-5673000" name="RAF activation"/>
            <pathway-xref db="Reactome" id="R-HSA-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-5673000" name="RAF activation"/>
            <pathway-xref db="Reactome" id="R-DRE-5675482" name="Regulation of necroptotic cell death"/>
            <pathway-xref db="Reactome" id="R-RNO-9696273" name="RND1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DME-8849932" name="Synaptic adhesion-like molecules"/>
            <pathway-xref db="Reactome" id="R-RNO-8849932" name="Synaptic adhesion-like molecules"/>
            <pathway-xref db="Reactome" id="R-MMU-9013407" name="RHOH GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-9013406" name="RHOQ GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-CEL-2672351" name="Stimuli-sensing channels"/>
            <pathway-xref db="Reactome" id="R-HSA-9013406" name="RHOQ GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-9013407" name="RHOH GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-8949664" name="Processing of SMDT1"/>
            <pathway-xref db="Reactome" id="R-SSC-5675482" name="Regulation of necroptotic cell death"/>
            <pathway-xref db="Reactome" id="R-HSA-6802946" name="Signaling by moderate kinase activity BRAF mutants"/>
            <pathway-xref db="Reactome" id="R-MMU-9013106" name="RHOC GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-9013409" name="RHOJ GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-CEL-9013407" name="RHOH GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-CEL-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-HSA-5675482" name="Regulation of necroptotic cell death"/>
            <pathway-xref db="Reactome" id="R-RNO-5675482" name="Regulation of necroptotic cell death"/>
            <pathway-xref db="Reactome" id="R-CEL-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-5213460" name="RIPK1-mediated regulated necrosis"/>
            <pathway-xref db="Reactome" id="R-HSA-2672351" name="Stimuli-sensing channels"/>
            <pathway-xref db="Reactome" id="R-SSC-9013106" name="RHOC GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DME-9013406" name="RHOQ GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-9013026" name="RHOB GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DRE-9696273" name="RND1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-373753" name="Nephrin family interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-9013026" name="RHOB GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-382556" name="ABC-family proteins mediated transport"/>
            <pathway-xref db="Reactome" id="R-MMU-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-9013148" name="CDC42 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DME-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-SSC-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-9696264" name="RND3 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-373753" name="Nephrin family interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-9649948" name="Signaling downstream of RAS mutants"/>
            <pathway-xref db="Reactome" id="R-BTA-9013106" name="RHOC GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DME-5673000" name="RAF activation"/>
            <pathway-xref db="Reactome" id="R-HSA-382556" name="ABC-family proteins mediated transport"/>
            <pathway-xref db="Reactome" id="R-HSA-9696273" name="RND1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-SSC-9013026" name="RHOB GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-CEL-9013406" name="RHOQ GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-8849932" name="Synaptic adhesion-like molecules"/>
            <pathway-xref db="Reactome" id="R-RNO-8949664" name="Processing of SMDT1"/>
            <pathway-xref db="Reactome" id="R-DME-9013407" name="RHOH GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-8849932" name="Synaptic adhesion-like molecules"/>
            <pathway-xref db="Reactome" id="R-DRE-5213460" name="RIPK1-mediated regulated necrosis"/>
            <pathway-xref db="Reactome" id="R-HSA-8853336" name="Signaling by plasma membrane FGFR1 fusions"/>
            <pathway-xref db="Reactome" id="R-DME-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-DME-8949664" name="Processing of SMDT1"/>
            <pathway-xref db="Reactome" id="R-DRE-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-5213460" name="RIPK1-mediated regulated necrosis"/>
            <pathway-xref db="Reactome" id="R-CEL-8949664" name="Processing of SMDT1"/>
            <pathway-xref db="Reactome" id="R-RNO-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-5673000" name="RAF activation"/>
            <pathway-xref db="Reactome" id="R-MMU-5675482" name="Regulation of necroptotic cell death"/>
            <pathway-xref db="Reactome" id="R-SSC-5213460" name="RIPK1-mediated regulated necrosis"/>
            <pathway-xref db="Reactome" id="R-DME-2672351" name="Stimuli-sensing channels"/>
            <pathway-xref db="Reactome" id="R-DRE-8849932" name="Synaptic adhesion-like molecules"/>
            <pathway-xref db="Reactome" id="R-MMU-373753" name="Nephrin family interactions"/>
            <pathway-xref db="Reactome" id="R-MMU-5213460" name="RIPK1-mediated regulated necrosis"/>
            <pathway-xref db="Reactome" id="R-MMU-2672351" name="Stimuli-sensing channels"/>
            <pathway-xref db="Reactome" id="R-RNO-9013106" name="RHOC GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-5678895" name="Defective CFTR causes cystic fibrosis"/>
            <pathway-xref db="Reactome" id="R-MMU-9013148" name="CDC42 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-BTA-5213460" name="RIPK1-mediated regulated necrosis"/>
            <pathway-xref db="Reactome" id="R-HSA-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-CEL-5673000" name="RAF activation"/>
            <pathway-xref db="Reactome" id="R-DRE-382556" name="ABC-family proteins mediated transport"/>
            <pathway-xref db="Reactome" id="R-DRE-9013106" name="RHOC GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-9696264" name="RND3 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-5655302" name="Signaling by FGFR1 in disease"/>
            <pathway-xref db="Reactome" id="R-DME-373753" name="Nephrin family interactions"/>
            <pathway-xref db="Reactome" id="R-MMU-9696273" name="RND1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-9696264" name="RND3 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-9013106" name="RHOC GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-6802955" name="Paradoxical activation of RAF signaling by kinase inactive BRAF"/>
          </entry>
          <signature-library-release library="SMART" version="7.1"/>
        </signature>
        <model-ac>SM00244</model-ac>
        <locations>
          <hmmer2-location score="68.1" evalue="1.1E-15" hmm-start="1" hmm-end="179" hmm-length="179" hmm-bounds="COMPLETE" start="99" end="260">
            <location-fragments>
              <hmmer2-location-fragment start="99" end="260" dc-status="CONTINUOUS"/>
            </location-fragments>
          </hmmer2-location>
        </locations>
      </hmmer2-match>
      <hmmer3-match evalue="1.1E-19" score="71.2">
        <signature ac="PF01145" desc="SPFH domain / Band 7 family" name="Band_7">
          <entry ac="IPR001107" desc="Band 7 domain" name="Band_7" type="DOMAIN">
            <pathway-xref db="Reactome" id="R-DRE-9696264" name="RND3 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-BTA-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-5673000" name="RAF activation"/>
            <pathway-xref db="Reactome" id="R-MMU-382556" name="ABC-family proteins mediated transport"/>
            <pathway-xref db="Reactome" id="R-HSA-8949664" name="Processing of SMDT1"/>
            <pathway-xref db="Reactome" id="R-MMU-9013026" name="RHOB GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-CEL-382556" name="ABC-family proteins mediated transport"/>
            <pathway-xref db="Reactome" id="R-SSC-8849932" name="Synaptic adhesion-like molecules"/>
            <pathway-xref db="Reactome" id="R-BTA-5673000" name="RAF activation"/>
            <pathway-xref db="Reactome" id="R-HSA-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-5673000" name="RAF activation"/>
            <pathway-xref db="Reactome" id="R-DRE-5675482" name="Regulation of necroptotic cell death"/>
            <pathway-xref db="Reactome" id="R-RNO-9696273" name="RND1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DME-8849932" name="Synaptic adhesion-like molecules"/>
            <pathway-xref db="Reactome" id="R-RNO-8849932" name="Synaptic adhesion-like molecules"/>
            <pathway-xref db="Reactome" id="R-MMU-9013407" name="RHOH GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-9013406" name="RHOQ GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-CEL-2672351" name="Stimuli-sensing channels"/>
            <pathway-xref db="Reactome" id="R-HSA-9013406" name="RHOQ GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-9013407" name="RHOH GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-8949664" name="Processing of SMDT1"/>
            <pathway-xref db="Reactome" id="R-SSC-5675482" name="Regulation of necroptotic cell death"/>
            <pathway-xref db="Reactome" id="R-HSA-6802946" name="Signaling by moderate kinase activity BRAF mutants"/>
            <pathway-xref db="Reactome" id="R-MMU-9013106" name="RHOC GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-9013409" name="RHOJ GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-CEL-9013407" name="RHOH GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-CEL-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-HSA-5675482" name="Regulation of necroptotic cell death"/>
            <pathway-xref db="Reactome" id="R-RNO-5675482" name="Regulation of necroptotic cell death"/>
            <pathway-xref db="Reactome" id="R-CEL-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-5213460" name="RIPK1-mediated regulated necrosis"/>
            <pathway-xref db="Reactome" id="R-HSA-2672351" name="Stimuli-sensing channels"/>
            <pathway-xref db="Reactome" id="R-SSC-9013106" name="RHOC GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DME-9013406" name="RHOQ GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-9013026" name="RHOB GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DRE-9696273" name="RND1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-373753" name="Nephrin family interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-9013026" name="RHOB GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-382556" name="ABC-family proteins mediated transport"/>
            <pathway-xref db="Reactome" id="R-MMU-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-9013148" name="CDC42 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DME-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-SSC-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-9696264" name="RND3 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-373753" name="Nephrin family interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-9649948" name="Signaling downstream of RAS mutants"/>
            <pathway-xref db="Reactome" id="R-BTA-9013106" name="RHOC GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DME-5673000" name="RAF activation"/>
            <pathway-xref db="Reactome" id="R-HSA-382556" name="ABC-family proteins mediated transport"/>
            <pathway-xref db="Reactome" id="R-HSA-9696273" name="RND1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-SSC-9013026" name="RHOB GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-CEL-9013406" name="RHOQ GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-8849932" name="Synaptic adhesion-like molecules"/>
            <pathway-xref db="Reactome" id="R-RNO-8949664" name="Processing of SMDT1"/>
            <pathway-xref db="Reactome" id="R-DME-9013407" name="RHOH GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-8849932" name="Synaptic adhesion-like molecules"/>
            <pathway-xref db="Reactome" id="R-DRE-5213460" name="RIPK1-mediated regulated necrosis"/>
            <pathway-xref db="Reactome" id="R-HSA-8853336" name="Signaling by plasma membrane FGFR1 fusions"/>
            <pathway-xref db="Reactome" id="R-DME-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-DME-8949664" name="Processing of SMDT1"/>
            <pathway-xref db="Reactome" id="R-DRE-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-5213460" name="RIPK1-mediated regulated necrosis"/>
            <pathway-xref db="Reactome" id="R-CEL-8949664" name="Processing of SMDT1"/>
            <pathway-xref db="Reactome" id="R-RNO-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-5673000" name="RAF activation"/>
            <pathway-xref db="Reactome" id="R-MMU-5675482" name="Regulation of necroptotic cell death"/>
            <pathway-xref db="Reactome" id="R-SSC-5213460" name="RIPK1-mediated regulated necrosis"/>
            <pathway-xref db="Reactome" id="R-DME-2672351" name="Stimuli-sensing channels"/>
            <pathway-xref db="Reactome" id="R-DRE-8849932" name="Synaptic adhesion-like molecules"/>
            <pathway-xref db="Reactome" id="R-MMU-373753" name="Nephrin family interactions"/>
            <pathway-xref db="Reactome" id="R-MMU-5213460" name="RIPK1-mediated regulated necrosis"/>
            <pathway-xref db="Reactome" id="R-MMU-2672351" name="Stimuli-sensing channels"/>
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          <signature-library-release library="PANTHER" version="15.0"/>
        </signature>
        <model-ac>PTHR10264</model-ac>
        <locations>
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            <location-fragments>
              <panther-location-fragment start="67" end="465" dc-status="CONTINUOUS"/>
            </location-fragments>
          </panther-location>
        </locations>
      </panther-match>
      <superfamilyhmmer3-match evalue="1.43E-10">
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            <pathway-xref db="MetaCyc" id="PWY-7730" name="T-2 toxin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6922" name="L-Ndelta-acetylornithine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5846" name="colchicine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5313" name="superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)"/>
            <pathway-xref db="MetaCyc" id="PWY-7577" name="ferrichrome biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7407" name="aurachin A, B, C and D biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6930" name="phenolic malonylglucosides biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7470" name="phosphatidylcholine biosynthesis VII"/>
            <pathway-xref db="MetaCyc" id="PWY-6627" name="salinosporamide A biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7708" name="lyngbyatoxin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-389887" name="Beta-oxidation of pristanoyl-CoA"/>
            <pathway-xref db="MetaCyc" id="PWY-7940" name="lauryl-hydroxychlorobactene glucoside biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5679" name="clavulanate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-2046106" name="alpha-linolenic acid (ALA) metabolism"/>
            <pathway-xref db="MetaCyc" id="PWY-6944" name="androstenedione degradation I (aerobic)"/>
            <pathway-xref db="MetaCyc" id="PWY-7405" name="aurachin RE biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6310" name="aloesone biosynthesis II"/>
            <pathway-xref db="MetaCyc" id="PWY-7561" name="tenellin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6039" name="chlorogenic acid biosynthesis I"/>
            <pathway-xref db="Reactome" id="R-HSA-193368" name="Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol"/>
            <pathway-xref db="MetaCyc" id="PWY-7987" name="vanchrobactin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6657" name="polyhydroxydecanoate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6945" name="cholesterol degradation to androstenedione I (cholesterol oxidase)"/>
            <pathway-xref db="MetaCyc" id="PWY-7464" name="cyanidin 3,7-diglucoside polyacylation biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7815" name="poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)"/>
            <pathway-xref db="MetaCyc" id="PWY-7726" name="(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)"/>
            <pathway-xref db="MetaCyc" id="PWY-8075" name="(Kdo)2-lipid A biosynthesis (P. putida)"/>
            <pathway-xref db="MetaCyc" id="PWY-7659" name="viridicatumtoxin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7821" name="tunicamycin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-84" name="resveratrol biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6883" name="pyruvate fermentation to butanol II (engineered)"/>
            <pathway-xref db="MetaCyc" id="PWY-5794" name="malonate degradation I (biotin-independent)"/>
            <pathway-xref db="Reactome" id="R-RNO-193368" name="Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol"/>
            <pathway-xref db="MetaCyc" id="PWY-7948" name="4-oxopentanoate degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7728" name="(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)"/>
            <pathway-xref db="MetaCyc" id="PWY-8210" name="pyrrolomycin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7288" name="fatty acid beta-oxidation VII (yeast peroxisome)"/>
            <pathway-xref db="MetaCyc" id="PWY-5292" name="vindoline, vindorosine and vinblastine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6821" name="kappa-carrageenan degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7280" name="ternatin C3 biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7029" name="terminal olefins biosynthesis II"/>
            <pathway-xref db="MetaCyc" id="PWY-7339" name="10-trans-heptadecenoyl-CoA degradation (MFE-dependent, yeast)"/>
            <pathway-xref db="MetaCyc" id="PWY-7670" name="fusaridione A biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7547" name="prodigiosin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-2046106" name="alpha-linolenic acid (ALA) metabolism"/>
            <pathway-xref db="MetaCyc" id="PWY-7984" name="acinetobactin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7660" name="tryptoquialanine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6027" name="capsiconiate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7907" name="(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7555" name="alpha-cyclopiazonate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7954" name="tabtoxinine-beta-lactam biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7746" name="mycobacterial sulfolipid biosynthesis"/>
          </entry>
          <signature-library-release library="SUPERFAMILY" version="1.75"/>
        </signature>
        <model-ac>0039068</model-ac>
        <locations>
          <superfamilyhmmer3-location hmm-length="115" start="373" end="461">
            <location-fragments>
              <superfamilyhmmer3-location-fragment start="373" end="461" dc-status="CONTINUOUS"/>
            </location-fragments>
          </superfamilyhmmer3-location>
        </locations>
      </superfamilyhmmer3-match>
      <superfamilyhmmer3-match evalue="6.41E-16">
        <signature ac="SSF117892" name="Band 7/SPFH domain">
          <entry ac="IPR036013" desc="Band 7/SPFH domain superfamily" name="Band_7/SPFH_dom_sf" type="HOMOLOGOUS_SUPERFAMILY">
            <pathway-xref db="Reactome" id="R-DRE-9696264" name="RND3 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-BTA-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-5673000" name="RAF activation"/>
            <pathway-xref db="Reactome" id="R-MMU-382556" name="ABC-family proteins mediated transport"/>
            <pathway-xref db="Reactome" id="R-HSA-8949664" name="Processing of SMDT1"/>
            <pathway-xref db="Reactome" id="R-MMU-9013026" name="RHOB GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-CEL-382556" name="ABC-family proteins mediated transport"/>
            <pathway-xref db="Reactome" id="R-SSC-8849932" name="Synaptic adhesion-like molecules"/>
            <pathway-xref db="Reactome" id="R-BTA-5673000" name="RAF activation"/>
            <pathway-xref db="Reactome" id="R-HSA-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-5673000" name="RAF activation"/>
            <pathway-xref db="Reactome" id="R-DRE-5675482" name="Regulation of necroptotic cell death"/>
            <pathway-xref db="Reactome" id="R-RNO-9696273" name="RND1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DME-8849932" name="Synaptic adhesion-like molecules"/>
            <pathway-xref db="Reactome" id="R-RNO-8849932" name="Synaptic adhesion-like molecules"/>
            <pathway-xref db="Reactome" id="R-MMU-9013407" name="RHOH GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-9013406" name="RHOQ GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-CEL-2672351" name="Stimuli-sensing channels"/>
            <pathway-xref db="Reactome" id="R-HSA-9013406" name="RHOQ GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-9013407" name="RHOH GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-8949664" name="Processing of SMDT1"/>
            <pathway-xref db="Reactome" id="R-SSC-5675482" name="Regulation of necroptotic cell death"/>
            <pathway-xref db="Reactome" id="R-HSA-6802946" name="Signaling by moderate kinase activity BRAF mutants"/>
            <pathway-xref db="Reactome" id="R-MMU-9013106" name="RHOC GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-9013409" name="RHOJ GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-CEL-9013407" name="RHOH GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-CEL-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-HSA-5675482" name="Regulation of necroptotic cell death"/>
            <pathway-xref db="Reactome" id="R-RNO-5675482" name="Regulation of necroptotic cell death"/>
            <pathway-xref db="Reactome" id="R-CEL-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-5213460" name="RIPK1-mediated regulated necrosis"/>
            <pathway-xref db="Reactome" id="R-HSA-2672351" name="Stimuli-sensing channels"/>
            <pathway-xref db="Reactome" id="R-SSC-9013106" name="RHOC GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DME-9013406" name="RHOQ GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-9013026" name="RHOB GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DRE-9696273" name="RND1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-373753" name="Nephrin family interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-9013026" name="RHOB GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-382556" name="ABC-family proteins mediated transport"/>
            <pathway-xref db="Reactome" id="R-MMU-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-9013148" name="CDC42 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DME-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-SSC-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-9696264" name="RND3 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-373753" name="Nephrin family interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-9649948" name="Signaling downstream of RAS mutants"/>
            <pathway-xref db="Reactome" id="R-BTA-9013106" name="RHOC GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DME-5673000" name="RAF activation"/>
            <pathway-xref db="Reactome" id="R-HSA-382556" name="ABC-family proteins mediated transport"/>
            <pathway-xref db="Reactome" id="R-HSA-9696273" name="RND1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-SSC-9013026" name="RHOB GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-CEL-9013406" name="RHOQ GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-8849932" name="Synaptic adhesion-like molecules"/>
            <pathway-xref db="Reactome" id="R-DRE-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-RNO-8949664" name="Processing of SMDT1"/>
            <pathway-xref db="Reactome" id="R-DME-9013407" name="RHOH GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-8849932" name="Synaptic adhesion-like molecules"/>
            <pathway-xref db="Reactome" id="R-DRE-5213460" name="RIPK1-mediated regulated necrosis"/>
            <pathway-xref db="Reactome" id="R-HSA-8853336" name="Signaling by plasma membrane FGFR1 fusions"/>
            <pathway-xref db="Reactome" id="R-DME-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-DME-8949664" name="Processing of SMDT1"/>
            <pathway-xref db="Reactome" id="R-DRE-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-5213460" name="RIPK1-mediated regulated necrosis"/>
            <pathway-xref db="Reactome" id="R-CEL-8949664" name="Processing of SMDT1"/>
            <pathway-xref db="Reactome" id="R-RNO-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-5673000" name="RAF activation"/>
            <pathway-xref db="Reactome" id="R-MMU-5675482" name="Regulation of necroptotic cell death"/>
            <pathway-xref db="Reactome" id="R-SSC-5213460" name="RIPK1-mediated regulated necrosis"/>
            <pathway-xref db="Reactome" id="R-DME-2672351" name="Stimuli-sensing channels"/>
            <pathway-xref db="Reactome" id="R-DRE-8849932" name="Synaptic adhesion-like molecules"/>
            <pathway-xref db="Reactome" id="R-MMU-373753" name="Nephrin family interactions"/>
            <pathway-xref db="Reactome" id="R-MMU-5213460" name="RIPK1-mediated regulated necrosis"/>
            <pathway-xref db="Reactome" id="R-MMU-2672351" name="Stimuli-sensing channels"/>
            <pathway-xref db="Reactome" id="R-RNO-9013106" name="RHOC GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DDI-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-HSA-5678895" name="Defective CFTR causes cystic fibrosis"/>
            <pathway-xref db="Reactome" id="R-MMU-9013148" name="CDC42 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-BTA-5213460" name="RIPK1-mediated regulated necrosis"/>
            <pathway-xref db="Reactome" id="R-HSA-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-CEL-5673000" name="RAF activation"/>
            <pathway-xref db="Reactome" id="R-DRE-382556" name="ABC-family proteins mediated transport"/>
            <pathway-xref db="Reactome" id="R-DRE-9013106" name="RHOC GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-9696264" name="RND3 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-HSA-5655302" name="Signaling by FGFR1 in disease"/>
            <pathway-xref db="Reactome" id="R-DME-373753" name="Nephrin family interactions"/>
            <pathway-xref db="Reactome" id="R-MMU-9696273" name="RND1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-9696264" name="RND3 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-9013106" name="RHOC GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-6802955" name="Paradoxical activation of RAF signaling by kinase inactive BRAF"/>
          </entry>
          <signature-library-release library="SUPERFAMILY" version="1.75"/>
        </signature>
        <model-ac>0050593</model-ac>
        <locations>
          <superfamilyhmmer3-location hmm-length="143" start="130" end="240">
            <location-fragments>
              <superfamilyhmmer3-location-fragment start="130" end="240" dc-status="CONTINUOUS"/>
            </location-fragments>
          </superfamilyhmmer3-location>
        </locations>
      </superfamilyhmmer3-match>
    </matches>
  </protein>
  <protein>
    <sequence md5="9c10ebbd6b85fe62a451d20f409fbb55">MVELTTPTTLTNFEDLLNLIGGWCRYQKTLLAFFFFNCMFLAYAAYTPVLFLYTPDHFCSVDHIWNATGSQELLWHEDQVLNLLIPIEEFSGKRSKCLMYNVSVDVLSELTALEMENRTEFEKIPCSHGWYYNTTGLFTSVITDMDWVCDDAWKGPFSQSMFSIGALFGTLLFGYMADTYGRLSAWYASNIVLMVAGLATPFMSEFIGFSCMRFLQGMSYDSFFTIFYVLALECVSSDKRALIGNLALAIGMTVAGCYEPWTLYFLQNWKILNTILYAQVAVIILAPWFVFESIRWLASQGRIDEAYETILKIAKVNGMEIDPSLESQIKKILANEEEIKPEGEMQKKATLLDLMRKPNLRKNFIIMVIVFMLTYGLFDTNVRVIGNLEQSIYITFTISSFLELPADLLAILGLDWIGRRWSAFTSLLFSGIAMGVGSLMTSYPLIVMILTMFGRFFVTYALNTALNIGLEIIPTVVRGQGLAVGRLMSCLAIFCSPYIVFTGTIDKSIPYIIIAIVSFFAACMATLLPETADEELPDTLEDGEKFGKKQSFWNVPFLKNRKETQQINL</sequence>
    <xref id="TCALIF_00766-PA" name="TCALIF_00766-PA protein Name:&quot;Similar to Slc22a1 Solute carrier family 22 member 1 (Rattus norvegicus)&quot; AED:0.10 eAED:0.10 QI:0|1|0.88|1|1|1|9|147|569"/>
    <matches>
      <hmmer3-match evalue="4.2E-14" score="52.3">
        <signature ac="PF00083" desc="Sugar (and other) transporter" name="Sugar_tr">
          <entry ac="IPR005828" desc="Major facilitator,  sugar transporter-like" name="MFS_sugar_transport-like" type="FAMILY">
            <go-xref category="CELLULAR_COMPONENT" db="GO" id="GO:0016021" name="integral component of membrane"/>
            <go-xref category="BIOLOGICAL_PROCESS" db="GO" id="GO:0055085" name="transmembrane transport"/>
            <go-xref category="MOLECULAR_FUNCTION" db="GO" id="GO:0022857" name="transmembrane transporter activity"/>
            <pathway-xref db="Reactome" id="R-HSA-189200" name="Cellular hexose transport"/>
            <pathway-xref db="Reactome" id="R-HSA-5619047" name="Defective SLC2A9 causes hypouricemia renal 2 (RHUC2)"/>
            <pathway-xref db="Reactome" id="R-MMU-181430" name="Norepinephrine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-2161517" name="Abacavir transmembrane transport"/>
            <pathway-xref db="Reactome" id="R-HSA-5653890" name="Lactose synthesis"/>
            <pathway-xref db="Reactome" id="R-DME-8981373" name="Intestinal hexose absorption"/>
            <pathway-xref db="Reactome" id="R-SCE-8981373" name="Intestinal hexose absorption"/>
            <pathway-xref db="Reactome" id="R-HSA-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-SSC-422356" name="Regulation of insulin secretion"/>
            <pathway-xref db="Reactome" id="R-MMU-112311" name="Neurotransmitter clearance"/>
            <pathway-xref db="Reactome" id="R-HSA-9022699" name="MECP2 regulates neuronal receptors and channels"/>
            <pathway-xref db="Reactome" id="R-BTA-189200" name="Cellular hexose transport"/>
            <pathway-xref db="Reactome" id="R-RNO-189200" name="Cellular hexose transport"/>
            <pathway-xref db="Reactome" id="R-BTA-181430" name="Norepinephrine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-561048" name="Organic anion transport"/>
            <pathway-xref db="Reactome" id="R-HSA-561048" name="Organic anion transport"/>
            <pathway-xref db="Reactome" id="R-MMU-200425" name="Carnitine metabolism"/>
            <pathway-xref db="Reactome" id="R-HSA-917937" name="Iron uptake and transport"/>
            <pathway-xref db="Reactome" id="R-MMU-197264" name="Nicotinamide salvaging"/>
            <pathway-xref db="Reactome" id="R-HSA-8856828" name="Clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-HSA-5250992" name="Toxicity of botulinum toxin type E (botE)"/>
            <pathway-xref db="Reactome" id="R-HSA-8981373" name="Intestinal hexose absorption"/>
            <pathway-xref db="Reactome" id="R-HSA-5250968" name="Toxicity of botulinum toxin type A (botA)"/>
            <pathway-xref db="Reactome" id="R-MMU-549127" name="Organic cation transport"/>
            <pathway-xref db="Reactome" id="R-RNO-442660" name="Na+/Cl- dependent neurotransmitter transporters"/>
            <pathway-xref db="Reactome" id="R-CEL-422356" name="Regulation of insulin secretion"/>
            <pathway-xref db="Reactome" id="R-DME-422356" name="Regulation of insulin secretion"/>
            <pathway-xref db="Reactome" id="R-HSA-112311" name="Neurotransmitter clearance"/>
            <pathway-xref db="Reactome" id="R-HSA-5619071" name="Defective SLC22A12 causes renal hypouricemia 1 (RHUC1)"/>
            <pathway-xref db="Reactome" id="R-RNO-196836" name="Vitamin C (ascorbate) metabolism"/>
            <pathway-xref db="Reactome" id="R-MMU-189200" name="Cellular hexose transport"/>
            <pathway-xref db="Reactome" id="R-SCE-422356" name="Regulation of insulin secretion"/>
            <pathway-xref db="Reactome" id="R-HSA-181430" name="Norepinephrine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-561048" name="Organic anion transport"/>
            <pathway-xref db="Reactome" id="R-DME-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-SSC-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-HSA-381340" name="Transcriptional regulation of white adipocyte differentiation"/>
            <pathway-xref db="Reactome" id="R-RNO-200425" name="Carnitine metabolism"/>
            <pathway-xref db="Reactome" id="R-MMU-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-HSA-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-SCE-429593" name="Inositol transporters"/>
            <pathway-xref db="Reactome" id="R-SSC-8981373" name="Intestinal hexose absorption"/>
            <pathway-xref db="Reactome" id="R-RNO-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-CEL-8981373" name="Intestinal hexose absorption"/>
            <pathway-xref db="Reactome" id="R-CEL-429593" name="Inositol transporters"/>
            <pathway-xref db="Reactome" id="R-MMU-5653890" name="Lactose synthesis"/>
            <pathway-xref db="Reactome" id="R-BTA-442660" name="Na+/Cl- dependent neurotransmitter transporters"/>
            <pathway-xref db="Reactome" id="R-XTR-189200" name="Cellular hexose transport"/>
            <pathway-xref db="Reactome" id="R-MMU-8856828" name="Clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-HSA-549127" name="Organic cation transport"/>
            <pathway-xref db="Reactome" id="R-HSA-5619068" name="Defective SLC2A10 causes arterial tortuosity syndrome (ATS)"/>
            <pathway-xref db="Reactome" id="R-RNO-8981373" name="Intestinal hexose absorption"/>
            <pathway-xref db="Reactome" id="R-SSC-196836" name="Vitamin C (ascorbate) metabolism"/>
            <pathway-xref db="Reactome" id="R-HSA-422356" name="Regulation of insulin secretion"/>
            <pathway-xref db="Reactome" id="R-HSA-429593" name="Inositol transporters"/>
            <pathway-xref db="Reactome" id="R-HSA-200425" name="Carnitine metabolism"/>
            <pathway-xref db="Reactome" id="R-SPO-429593" name="Inositol transporters"/>
            <pathway-xref db="Reactome" id="R-GGA-352832" name="Glucose transport"/>
            <pathway-xref db="Reactome" id="R-HSA-197264" name="Nicotinamide salvaging"/>
            <pathway-xref db="Reactome" id="R-MMU-196836" name="Vitamin C (ascorbate) metabolism"/>
            <pathway-xref db="Reactome" id="R-MMU-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-CEL-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-BTA-549127" name="Organic cation transport"/>
            <pathway-xref db="Reactome" id="R-BTA-2161517" name="Abacavir transmembrane transport"/>
            <pathway-xref db="Reactome" id="R-MMU-442660" name="Na+/Cl- dependent neurotransmitter transporters"/>
            <pathway-xref db="Reactome" id="R-HSA-210745" name="Regulation of gene expression in beta cells"/>
            <pathway-xref db="Reactome" id="R-RNO-549127" name="Organic cation transport"/>
            <pathway-xref db="Reactome" id="R-HSA-5619098" name="Defective SLC2A2 causes Fanconi-Bickel syndrome (FBS)"/>
            <pathway-xref db="Reactome" id="R-CEL-197264" name="Nicotinamide salvaging"/>
            <pathway-xref db="Reactome" id="R-SCE-196836" name="Vitamin C (ascorbate) metabolism"/>
            <pathway-xref db="Reactome" id="R-HSA-5250981" name="Toxicity of botulinum toxin type F (botF)"/>
            <pathway-xref db="Reactome" id="R-CEL-200425" name="Carnitine metabolism"/>
            <pathway-xref db="Reactome" id="R-HSA-1445148" name="Translocation of SLC2A4 (GLUT4) to the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-RNO-429593" name="Inositol transporters"/>
            <pathway-xref db="Reactome" id="R-RNO-422356" name="Regulation of insulin secretion"/>
            <pathway-xref db="Reactome" id="R-RNO-917937" name="Iron uptake and transport"/>
            <pathway-xref db="Reactome" id="R-HSA-5619043" name="Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1)"/>
            <pathway-xref db="Reactome" id="R-SCE-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-DME-561048" name="Organic anion transport"/>
            <pathway-xref db="Reactome" id="R-MMU-429593" name="Inositol transporters"/>
            <pathway-xref db="Reactome" id="R-DME-197264" name="Nicotinamide salvaging"/>
            <pathway-xref db="Reactome" id="R-SCE-5653890" name="Lactose synthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-549127" name="Organic cation transport"/>
            <pathway-xref db="Reactome" id="R-CEL-189200" name="Cellular hexose transport"/>
            <pathway-xref db="Reactome" id="R-RNO-8856828" name="Clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-RNO-5653890" name="Lactose synthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-442660" name="Na+/Cl- dependent neurotransmitter transporters"/>
            <pathway-xref db="Reactome" id="R-BTA-112311" name="Neurotransmitter clearance"/>
            <pathway-xref db="Reactome" id="R-RNO-181430" name="Norepinephrine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-112311" name="Neurotransmitter clearance"/>
            <pathway-xref db="Reactome" id="R-HSA-5619053" name="Defective SLC22A5 causes systemic primary carnitine deficiency (CDSP)"/>
            <pathway-xref db="Reactome" id="R-CEL-561048" name="Organic anion transport"/>
            <pathway-xref db="Reactome" id="R-HSA-5250955" name="Toxicity of botulinum toxin type D (botD)"/>
            <pathway-xref db="Reactome" id="R-RNO-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-MMU-917937" name="Iron uptake and transport"/>
            <pathway-xref db="Reactome" id="R-SSC-189200" name="Cellular hexose transport"/>
            <pathway-xref db="Reactome" id="R-SSC-561048" name="Organic anion transport"/>
            <pathway-xref db="Reactome" id="R-DME-189200" name="Cellular hexose transport"/>
            <pathway-xref db="Reactome" id="R-MMU-8981373" name="Intestinal hexose absorption"/>
            <pathway-xref db="Reactome" id="R-HSA-2161517" name="Abacavir transmembrane transport"/>
            <pathway-xref db="Reactome" id="R-SCE-189200" name="Cellular hexose transport"/>
            <pathway-xref db="Reactome" id="R-DRE-561048" name="Organic anion transport"/>
            <pathway-xref db="Reactome" id="R-MMU-422356" name="Regulation of insulin secretion"/>
            <pathway-xref db="Reactome" id="R-DRE-189200" name="Cellular hexose transport"/>
            <pathway-xref db="Reactome" id="R-RNO-2161517" name="Abacavir transmembrane transport"/>
            <pathway-xref db="Reactome" id="R-HSA-196836" name="Vitamin C (ascorbate) metabolism"/>
          </entry>
          <signature-library-release library="PFAM" version="34.0"/>
        </signature>
        <model-ac>PF00083</model-ac>
        <locations>
          <hmmer3-location env-end="540" env-start="150" post-processed="true" score="51.0" evalue="1.0E-13" hmm-start="52" hmm-end="445" hmm-length="452" hmm-bounds="INCOMPLETE" start="159" end="536">
            <location-fragments>
              <hmmer3-location-fragment start="159" end="536" dc-status="CONTINUOUS"/>
            </location-fragments>
          </hmmer3-location>
        </locations>
      </hmmer3-match>
      <hmmer3-match evalue="2.5E-49" score="170.3">
        <signature ac="G3DSA:1.20.1250.20" name="MFS general substrate transporter like domains">
          <entry ac="IPR036259" desc="MFS transporter superfamily" name="MFS_trans_sf" type="HOMOLOGOUS_SUPERFAMILY">
            <pathway-xref db="Reactome" id="R-CEL-210500" name="Glutamate Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-GGA-373920" name="Pyruvate metabolism"/>
            <pathway-xref db="Reactome" id="R-RNO-425397" name="Transport of vitamins, nucleosides, and related molecules"/>
            <pathway-xref db="Reactome" id="R-MMU-181430" name="Norepinephrine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-879518" name="Transport of organic anions"/>
            <pathway-xref db="Reactome" id="R-SPO-442380" name="Zinc influx into cells by the SLC39 gene family"/>
            <pathway-xref db="Reactome" id="R-MMU-2161517" name="Abacavir transmembrane transport"/>
            <pathway-xref db="Reactome" id="R-HSA-352230" name="Amino acid transport across the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-HSA-5653890" name="Lactose synthesis"/>
            <pathway-xref db="Reactome" id="R-SCE-8981373" name="Intestinal hexose absorption"/>
            <pathway-xref db="Reactome" id="R-HSA-427975" name="Proton/oligopeptide cotransporters"/>
            <pathway-xref db="Reactome" id="R-HSA-5655799" name="Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum)"/>
            <pathway-xref db="Reactome" id="R-RNO-425410" name="Metal ion SLC transporters"/>
            <pathway-xref db="Reactome" id="R-CEL-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-HSA-196819" name="Vitamin B1 (thiamin) metabolism"/>
            <pathway-xref db="Reactome" id="R-HSA-428643" name="Organic anion transporters"/>
            <pathway-xref db="Reactome" id="R-RNO-196757" name="Metabolism of folate and pterines"/>
            <pathway-xref db="Reactome" id="R-CEL-4085001" name="Sialic acid metabolism"/>
            <pathway-xref db="Reactome" id="R-DRE-352230" name="Amino acid transport across the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-BTA-352230" name="Amino acid transport across the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-DRE-427975" name="Proton/oligopeptide cotransporters"/>
            <pathway-xref db="Reactome" id="R-RNO-189200" name="Cellular hexose transport"/>
            <pathway-xref db="Reactome" id="R-BTA-181430" name="Norepinephrine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-70268" name="Pyruvate metabolism"/>
            <pathway-xref db="Reactome" id="R-DRE-1483191" name="Synthesis of PC"/>
            <pathway-xref db="Reactome" id="R-DDI-196757" name="Metabolism of folate and pterines"/>
            <pathway-xref db="Reactome" id="R-RNO-159418" name="Recycling of bile acids and salts"/>
            <pathway-xref db="Reactome" id="R-HSA-561048" name="Organic anion transport"/>
            <pathway-xref db="Reactome" id="R-MMU-200425" name="Carnitine metabolism"/>
            <pathway-xref db="Reactome" id="R-CEL-264642" name="Acetylcholine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-SPO-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-MMU-9707616" name="Heme signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-5619049" name="Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages)"/>
            <pathway-xref db="Reactome" id="R-BTA-428643" name="Organic anion transporters"/>
            <pathway-xref db="Reactome" id="R-RNO-433692" name="Proton-coupled monocarboxylate transport"/>
            <pathway-xref db="Reactome" id="R-DRE-428643" name="Organic anion transporters"/>
            <pathway-xref db="Reactome" id="R-DME-422356" name="Regulation of insulin secretion"/>
            <pathway-xref db="Reactome" id="R-CEL-196757" name="Metabolism of folate and pterines"/>
            <pathway-xref db="MetaCyc" id="PWY-7975" name="adenosylcobalamin biosynthesis from adenosylcobinamide-GDP II"/>
            <pathway-xref db="Reactome" id="R-DRE-8856828" name="Clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-HSA-181430" name="Norepinephrine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-5619095" name="Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2)"/>
            <pathway-xref db="Reactome" id="R-MMU-352230" name="Amino acid transport across the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-SPO-8856828" name="Clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-MMU-561048" name="Organic anion transport"/>
            <pathway-xref db="Reactome" id="R-DRE-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-DME-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-RNO-210500" name="Glutamate Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-SPO-425397" name="Transport of vitamins, nucleosides, and related molecules"/>
            <pathway-xref db="Reactome" id="R-MMU-212676" name="Dopamine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-XTR-1483191" name="Synthesis of PC"/>
            <pathway-xref db="Reactome" id="R-SPO-917937" name="Iron uptake and transport"/>
            <pathway-xref db="Reactome" id="R-SCE-429593" name="Inositol transporters"/>
            <pathway-xref db="Reactome" id="R-HSA-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-SPO-879518" name="Transport of organic anions"/>
            <pathway-xref db="Reactome" id="R-SSC-8981373" name="Intestinal hexose absorption"/>
            <pathway-xref db="Reactome" id="R-SPO-196757" name="Metabolism of folate and pterines"/>
            <pathway-xref db="MetaCyc" id="PWY-6322" name="phosphinothricin tripeptide biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-8981373" name="Intestinal hexose absorption"/>
            <pathway-xref db="Reactome" id="R-CEL-429593" name="Inositol transporters"/>
            <pathway-xref db="Reactome" id="R-MMU-5653890" name="Lactose synthesis"/>
            <pathway-xref db="Reactome" id="R-SPO-181429" name="Serotonin Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-264642" name="Acetylcholine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-BTA-442660" name="Na+/Cl- dependent neurotransmitter transporters"/>
            <pathway-xref db="Reactome" id="R-XTR-189200" name="Cellular hexose transport"/>
            <pathway-xref db="Reactome" id="R-HSA-70263" name="Gluconeogenesis"/>
            <pathway-xref db="Reactome" id="R-HSA-5662702" name="Melanin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-549127" name="Organic cation transport"/>
            <pathway-xref db="Reactome" id="R-HSA-210991" name="Basigin interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-5619110" name="Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR)"/>
            <pathway-xref db="Reactome" id="R-XTR-210500" name="Glutamate Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-422356" name="Regulation of insulin secretion"/>
            <pathway-xref db="Reactome" id="R-HSA-429593" name="Inositol transporters"/>
            <pathway-xref db="Reactome" id="R-SPO-429593" name="Inositol transporters"/>
            <pathway-xref db="Reactome" id="R-GGA-352832" name="Glucose transport"/>
            <pathway-xref db="Reactome" id="R-HSA-1660661" name="Sphingolipid de novo biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-5619061" name="Defective SLC33A1 causes spastic paraplegia 42 (SPG42)"/>
            <pathway-xref db="Reactome" id="R-DME-879518" name="Transport of organic anions"/>
            <pathway-xref db="Reactome" id="R-MMU-210500" name="Glutamate Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-210991" name="Basigin interactions"/>
            <pathway-xref db="Reactome" id="R-BTA-549127" name="Organic cation transport"/>
            <pathway-xref db="Reactome" id="R-HSA-351906" name="Apoptotic cleavage of cell adhesion proteins"/>
            <pathway-xref db="Reactome" id="R-MMU-442660" name="Na+/Cl- dependent neurotransmitter transporters"/>
            <pathway-xref db="Reactome" id="R-RNO-212676" name="Dopamine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-SCE-196836" name="Vitamin C (ascorbate) metabolism"/>
            <pathway-xref db="Reactome" id="R-CEL-197264" name="Nicotinamide salvaging"/>
            <pathway-xref db="MetaCyc" id="PWY-7740" name="beta-D-mannosyl phosphomycoketide biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-200425" name="Carnitine metabolism"/>
            <pathway-xref db="Reactome" id="R-SPO-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-RNO-429593" name="Inositol transporters"/>
            <pathway-xref db="Reactome" id="R-RNO-422356" name="Regulation of insulin secretion"/>
            <pathway-xref db="Reactome" id="R-MMU-427975" name="Proton/oligopeptide cotransporters"/>
            <pathway-xref db="Reactome" id="R-RNO-181429" name="Serotonin Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-917937" name="Iron uptake and transport"/>
            <pathway-xref db="Reactome" id="R-HSA-5619043" name="Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1)"/>
            <pathway-xref db="Reactome" id="R-HSA-5619060" name="Defective CP causes aceruloplasminemia (ACERULOP)"/>
            <pathway-xref db="Reactome" id="R-MMU-196757" name="Metabolism of folate and pterines"/>
            <pathway-xref db="Reactome" id="R-SCE-5653890" name="Lactose synthesis"/>
            <pathway-xref db="Reactome" id="R-SCE-352230" name="Amino acid transport across the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-HSA-264642" name="Acetylcholine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-8856828" name="Clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-RNO-181430" name="Norepinephrine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-DRE-425410" name="Metal ion SLC transporters"/>
            <pathway-xref db="Reactome" id="R-MMU-879518" name="Transport of organic anions"/>
            <pathway-xref db="MetaCyc" id="PWY-5129" name="sphingolipid biosynthesis (plants)"/>
            <pathway-xref db="Reactome" id="R-RNO-112311" name="Neurotransmitter clearance"/>
            <pathway-xref db="Reactome" id="R-HSA-5619053" name="Defective SLC22A5 causes systemic primary carnitine deficiency (CDSP)"/>
            <pathway-xref db="Reactome" id="R-DRE-1660661" name="Sphingolipid de novo biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-189483" name="Heme degradation"/>
            <pathway-xref db="Reactome" id="R-CEL-561048" name="Organic anion transport"/>
            <pathway-xref db="Reactome" id="R-HSA-5250955" name="Toxicity of botulinum toxin type D (botD)"/>
            <pathway-xref db="Reactome" id="R-MMU-196819" name="Vitamin B1 (thiamin) metabolism"/>
            <pathway-xref db="Reactome" id="R-RNO-9707616" name="Heme signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-1660661" name="Sphingolipid de novo biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9707616" name="Heme signaling"/>
            <pathway-xref db="Reactome" id="R-BTA-196757" name="Metabolism of folate and pterines"/>
            <pathway-xref db="MetaCyc" id="PWY-7886" name="cell-surface glycoconjugate-linked phosphocholine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SSC-561048" name="Organic anion transport"/>
            <pathway-xref db="Reactome" id="R-DME-189200" name="Cellular hexose transport"/>
            <pathway-xref db="Reactome" id="R-SPO-189200" name="Cellular hexose transport"/>
            <pathway-xref db="Reactome" id="R-HSA-2161517" name="Abacavir transmembrane transport"/>
            <pathway-xref db="Reactome" id="R-MMU-425397" name="Transport of vitamins, nucleosides, and related molecules"/>
            <pathway-xref db="Reactome" id="R-DRE-561048" name="Organic anion transport"/>
            <pathway-xref db="Reactome" id="R-SCE-189200" name="Cellular hexose transport"/>
            <pathway-xref db="Reactome" id="R-DME-8856828" name="Clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-RNO-2161517" name="Abacavir transmembrane transport"/>
            <pathway-xref db="Reactome" id="R-HSA-196836" name="Vitamin C (ascorbate) metabolism"/>
            <pathway-xref db="Reactome" id="R-HSA-189200" name="Cellular hexose transport"/>
            <pathway-xref db="Reactome" id="R-HSA-5619047" name="Defective SLC2A9 causes hypouricemia renal 2 (RHUC2)"/>
            <pathway-xref db="Reactome" id="R-HSA-196757" name="Metabolism of folate and pterines"/>
            <pathway-xref db="Reactome" id="R-SPO-9707616" name="Heme signaling"/>
            <pathway-xref db="Reactome" id="R-SPO-427975" name="Proton/oligopeptide cotransporters"/>
            <pathway-xref db="Reactome" id="R-SPO-352230" name="Amino acid transport across the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-BTA-879518" name="Transport of organic anions"/>
            <pathway-xref db="Reactome" id="R-HSA-425410" name="Metal ion SLC transporters"/>
            <pathway-xref db="Reactome" id="R-RNO-428643" name="Organic anion transporters"/>
            <pathway-xref db="Reactome" id="R-HSA-3229133" name="Glycogen storage disease type Ib (SLC37A4)"/>
            <pathway-xref db="Reactome" id="R-DME-8981373" name="Intestinal hexose absorption"/>
            <pathway-xref db="Reactome" id="R-DRE-83936" name="Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-SCE-83936" name="Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-HSA-425397" name="Transport of vitamins, nucleosides, and related molecules"/>
            <pathway-xref db="Reactome" id="R-HSA-879518" name="Transport of organic anions"/>
            <pathway-xref db="Reactome" id="R-SCE-9707616" name="Heme signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-SSC-422356" name="Regulation of insulin secretion"/>
            <pathway-xref db="Reactome" id="R-MMU-112311" name="Neurotransmitter clearance"/>
            <pathway-xref db="Reactome" id="R-HSA-159418" name="Recycling of bile acids and salts"/>
            <pathway-xref db="Reactome" id="R-SCE-425397" name="Transport of vitamins, nucleosides, and related molecules"/>
            <pathway-xref db="Reactome" id="R-DDI-196819" name="Vitamin B1 (thiamin) metabolism"/>
            <pathway-xref db="Reactome" id="R-HSA-5619076" name="Defective SLC17A8 causes autosomal dominant deafness 25 (DFNA25)"/>
            <pathway-xref db="Reactome" id="R-SPO-442660" name="Na+/Cl- dependent neurotransmitter transporters"/>
            <pathway-xref db="Reactome" id="R-DME-264642" name="Acetylcholine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-9022699" name="MECP2 regulates neuronal receptors and channels"/>
            <pathway-xref db="Reactome" id="R-MMU-4085001" name="Sialic acid metabolism"/>
            <pathway-xref db="Reactome" id="R-BTA-189200" name="Cellular hexose transport"/>
            <pathway-xref db="Reactome" id="R-HSA-181429" name="Serotonin Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-2672351" name="Stimuli-sensing channels"/>
            <pathway-xref db="Reactome" id="R-RNO-561048" name="Organic anion transport"/>
            <pathway-xref db="Reactome" id="R-HSA-70268" name="Pyruvate metabolism"/>
            <pathway-xref db="Reactome" id="R-HSA-5619070" name="Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT)"/>
            <pathway-xref db="Reactome" id="R-HSA-917937" name="Iron uptake and transport"/>
            <pathway-xref db="Reactome" id="R-DRE-264642" name="Acetylcholine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-197264" name="Nicotinamide salvaging"/>
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            <pathway-xref db="Reactome" id="R-RNO-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-HSA-9707616" name="Heme signaling"/>
            <pathway-xref db="Reactome" id="R-BTA-196757" name="Metabolism of folate and pterines"/>
            <pathway-xref db="Reactome" id="R-MMU-917937" name="Iron uptake and transport"/>
            <pathway-xref db="Reactome" id="R-SSC-189200" name="Cellular hexose transport"/>
            <pathway-xref db="Reactome" id="R-SSC-561048" name="Organic anion transport"/>
            <pathway-xref db="Reactome" id="R-DME-189200" name="Cellular hexose transport"/>
            <pathway-xref db="Reactome" id="R-MMU-8981373" name="Intestinal hexose absorption"/>
            <pathway-xref db="Reactome" id="R-HSA-2161517" name="Abacavir transmembrane transport"/>
            <pathway-xref db="Reactome" id="R-SCE-189200" name="Cellular hexose transport"/>
            <pathway-xref db="Reactome" id="R-MMU-422356" name="Regulation of insulin secretion"/>
            <pathway-xref db="Reactome" id="R-DRE-189200" name="Cellular hexose transport"/>
            <pathway-xref db="Reactome" id="R-RNO-2161517" name="Abacavir transmembrane transport"/>
            <pathway-xref db="Reactome" id="R-HSA-196836" name="Vitamin C (ascorbate) metabolism"/>
          </entry>
          <signature-library-release library="PROSITE_PATTERNS" version="2021_01"/>
        </signature>
        <model-ac>PS00216</model-ac>
        <locations>
          <patternscan-location level="STRONG" start="410" end="426">
            <location-fragments>
              <patternscan-location-fragment start="410" end="426" dc-status="CONTINUOUS"/>
            </location-fragments>
            <alignment>AILGLDWIGRRwsaftS</alignment>
          </patternscan-location>
        </locations>
      </patternscan-match>
      <profilescan-match>
        <signature ac="PS50850" desc="Major facilitator superfamily (MFS) profile." name="MFS">
          <entry ac="IPR020846" desc="Major facilitator superfamily domain" name="MFS_dom" type="DOMAIN">
            <go-xref category="MOLECULAR_FUNCTION" db="GO" id="GO:0022857" name="transmembrane transporter activity"/>
            <pathway-xref db="Reactome" id="R-CEL-210500" name="Glutamate Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-GGA-373920" name="Pyruvate metabolism"/>
            <pathway-xref db="Reactome" id="R-MMU-181430" name="Norepinephrine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-879518" name="Transport of organic anions"/>
            <pathway-xref db="Reactome" id="R-MMU-2161517" name="Abacavir transmembrane transport"/>
            <pathway-xref db="Reactome" id="R-HSA-352230" name="Amino acid transport across the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-HSA-5653890" name="Lactose synthesis"/>
            <pathway-xref db="Reactome" id="R-SCE-8981373" name="Intestinal hexose absorption"/>
            <pathway-xref db="Reactome" id="R-CEL-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-HSA-428643" name="Organic anion transporters"/>
            <pathway-xref db="Reactome" id="R-RNO-196757" name="Metabolism of folate and pterines"/>
            <pathway-xref db="Reactome" id="R-CEL-4085001" name="Sialic acid metabolism"/>
            <pathway-xref db="Reactome" id="R-DRE-352230" name="Amino acid transport across the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-RNO-189200" name="Cellular hexose transport"/>
            <pathway-xref db="Reactome" id="R-BTA-181430" name="Norepinephrine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-70268" name="Pyruvate metabolism"/>
            <pathway-xref db="Reactome" id="R-RNO-159418" name="Recycling of bile acids and salts"/>
            <pathway-xref db="Reactome" id="R-HSA-561048" name="Organic anion transport"/>
            <pathway-xref db="Reactome" id="R-MMU-200425" name="Carnitine metabolism"/>
            <pathway-xref db="Reactome" id="R-CEL-264642" name="Acetylcholine Neurotransmitter Release Cycle"/>
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            <pathway-xref db="Reactome" id="R-BTA-428643" name="Organic anion transporters"/>
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            <pathway-xref db="Reactome" id="R-DRE-428643" name="Organic anion transporters"/>
            <pathway-xref db="Reactome" id="R-DME-422356" name="Regulation of insulin secretion"/>
            <pathway-xref db="Reactome" id="R-DRE-8856828" name="Clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-HSA-181430" name="Norepinephrine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-352230" name="Amino acid transport across the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-HSA-5619095" name="Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2)"/>
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            <pathway-xref db="Reactome" id="R-DRE-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-DME-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-RNO-210500" name="Glutamate Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-212676" name="Dopamine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-SCE-429593" name="Inositol transporters"/>
            <pathway-xref db="Reactome" id="R-HSA-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-SSC-8981373" name="Intestinal hexose absorption"/>
            <pathway-xref db="Reactome" id="R-CEL-8981373" name="Intestinal hexose absorption"/>
            <pathway-xref db="Reactome" id="R-CEL-429593" name="Inositol transporters"/>
            <pathway-xref db="Reactome" id="R-MMU-5653890" name="Lactose synthesis"/>
            <pathway-xref db="Reactome" id="R-SPO-181429" name="Serotonin Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-264642" name="Acetylcholine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-BTA-442660" name="Na+/Cl- dependent neurotransmitter transporters"/>
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            <pathway-xref db="Reactome" id="R-SPO-181430" name="Norepinephrine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-5619066" name="Defective SLC22A18 causes lung cancer (LNCR) and embryonal rhabdomyosarcoma 1 (RMSE1)"/>
            <pathway-xref db="Reactome" id="R-HSA-5250981" name="Toxicity of botulinum toxin type F (botF)"/>
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            <pathway-xref db="Reactome" id="R-MMU-429593" name="Inositol transporters"/>
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            <pathway-xref db="Reactome" id="R-CEL-549127" name="Organic cation transport"/>
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            <pathway-xref db="Reactome" id="R-DME-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
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            <pathway-xref db="Reactome" id="R-MMU-917937" name="Iron uptake and transport"/>
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            <pathway-xref db="Reactome" id="R-SPO-212676" name="Dopamine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-428643" name="Organic anion transporters"/>
            <pathway-xref db="Reactome" id="R-DRE-189200" name="Cellular hexose transport"/>
            <pathway-xref db="Reactome" id="R-CEL-8856828" name="Clathrin-mediated endocytosis"/>
          </entry>
          <signature-library-release library="PROSITE_PROFILES" version="2021_01"/>
        </signature>
        <model-ac>PS50850</model-ac>
        <locations>
          <profilescan-location score="9.357021" start="97" end="533">
            <location-fragments>
              <profilescan-location-fragment start="97" end="533" dc-status="CONTINUOUS"/>
            </location-fragments>
            <alignment>CLMYNVSVDVLSELTALEMenrtefekipcshgwyyntTGLFTSVITDMDWVCddaWKGPFSQSMFSIGALFGTLLFGYMADTYGRLSAWYASNIVLMVAGLATPFMSEFIGFSCMRFLQGMSYDSFFTIFYVLALECVSSDKRALIGNL---ALAIGMTVAGCYEPWTLyFLQNWKI-LNTILYAQVAVIILAPWFVFESIRWlasqgrideayetilKIAKVNGMEIDPSLESQIKKILANEEeikpegeMQKKATLLDLMRKPNLrknfiIMVIVFMLTYGLFDTNvrvIGNLEQSIYITFTISSF-LELPADLLAILGLDWIGRRWSAFTSLLFSGIAMGVGSLMTSYP--LIVMILTMFGRFFVTYALNTALNIGLEIIPTVVRGQGLAVGRLMSCLAIFCSPYIVFTG--TIDKSIPYIIIAIVSFFAACMATLLPETAD</alignment>
          </profilescan-location>
        </locations>
      </profilescan-match>
      <superfamilyhmmer3-match evalue="1.44E-35">
        <signature ac="SSF103473" name="MFS general substrate transporter">
          <entry ac="IPR036259" desc="MFS transporter superfamily" name="MFS_trans_sf" type="HOMOLOGOUS_SUPERFAMILY">
            <pathway-xref db="Reactome" id="R-CEL-210500" name="Glutamate Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-GGA-373920" name="Pyruvate metabolism"/>
            <pathway-xref db="Reactome" id="R-RNO-425397" name="Transport of vitamins, nucleosides, and related molecules"/>
            <pathway-xref db="Reactome" id="R-MMU-181430" name="Norepinephrine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-879518" name="Transport of organic anions"/>
            <pathway-xref db="Reactome" id="R-SPO-442380" name="Zinc influx into cells by the SLC39 gene family"/>
            <pathway-xref db="Reactome" id="R-MMU-2161517" name="Abacavir transmembrane transport"/>
            <pathway-xref db="Reactome" id="R-HSA-352230" name="Amino acid transport across the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-HSA-5653890" name="Lactose synthesis"/>
            <pathway-xref db="Reactome" id="R-SCE-8981373" name="Intestinal hexose absorption"/>
            <pathway-xref db="Reactome" id="R-HSA-427975" name="Proton/oligopeptide cotransporters"/>
            <pathway-xref db="Reactome" id="R-HSA-5655799" name="Defective SLC40A1 causes hemochromatosis 4 (HFE4) (duodenum)"/>
            <pathway-xref db="Reactome" id="R-RNO-425410" name="Metal ion SLC transporters"/>
            <pathway-xref db="Reactome" id="R-CEL-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-HSA-196819" name="Vitamin B1 (thiamin) metabolism"/>
            <pathway-xref db="Reactome" id="R-HSA-428643" name="Organic anion transporters"/>
            <pathway-xref db="Reactome" id="R-RNO-196757" name="Metabolism of folate and pterines"/>
            <pathway-xref db="Reactome" id="R-CEL-4085001" name="Sialic acid metabolism"/>
            <pathway-xref db="Reactome" id="R-DRE-352230" name="Amino acid transport across the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-BTA-352230" name="Amino acid transport across the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-DRE-427975" name="Proton/oligopeptide cotransporters"/>
            <pathway-xref db="Reactome" id="R-RNO-189200" name="Cellular hexose transport"/>
            <pathway-xref db="Reactome" id="R-BTA-181430" name="Norepinephrine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-70268" name="Pyruvate metabolism"/>
            <pathway-xref db="Reactome" id="R-DRE-1483191" name="Synthesis of PC"/>
            <pathway-xref db="Reactome" id="R-DDI-196757" name="Metabolism of folate and pterines"/>
            <pathway-xref db="Reactome" id="R-RNO-159418" name="Recycling of bile acids and salts"/>
            <pathway-xref db="Reactome" id="R-HSA-561048" name="Organic anion transport"/>
            <pathway-xref db="Reactome" id="R-MMU-200425" name="Carnitine metabolism"/>
            <pathway-xref db="Reactome" id="R-CEL-264642" name="Acetylcholine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-SPO-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-MMU-9707616" name="Heme signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-5619049" name="Defective SLC40A1 causes hemochromatosis 4 (HFE4) (macrophages)"/>
            <pathway-xref db="Reactome" id="R-BTA-428643" name="Organic anion transporters"/>
            <pathway-xref db="Reactome" id="R-RNO-433692" name="Proton-coupled monocarboxylate transport"/>
            <pathway-xref db="Reactome" id="R-DRE-428643" name="Organic anion transporters"/>
            <pathway-xref db="Reactome" id="R-DME-422356" name="Regulation of insulin secretion"/>
            <pathway-xref db="Reactome" id="R-CEL-196757" name="Metabolism of folate and pterines"/>
            <pathway-xref db="MetaCyc" id="PWY-7975" name="adenosylcobalamin biosynthesis from adenosylcobinamide-GDP II"/>
            <pathway-xref db="Reactome" id="R-DRE-8856828" name="Clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-HSA-181430" name="Norepinephrine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-5619095" name="Defective SLCO2A1 causes primary, autosomal recessive hypertrophic osteoarthropathy 2 (PHOAR2)"/>
            <pathway-xref db="Reactome" id="R-MMU-352230" name="Amino acid transport across the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-SPO-8856828" name="Clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-MMU-561048" name="Organic anion transport"/>
            <pathway-xref db="Reactome" id="R-DRE-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-DME-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-RNO-210500" name="Glutamate Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-SPO-425397" name="Transport of vitamins, nucleosides, and related molecules"/>
            <pathway-xref db="Reactome" id="R-MMU-212676" name="Dopamine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-XTR-1483191" name="Synthesis of PC"/>
            <pathway-xref db="Reactome" id="R-SPO-917937" name="Iron uptake and transport"/>
            <pathway-xref db="Reactome" id="R-SCE-429593" name="Inositol transporters"/>
            <pathway-xref db="Reactome" id="R-HSA-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-SPO-879518" name="Transport of organic anions"/>
            <pathway-xref db="Reactome" id="R-SSC-8981373" name="Intestinal hexose absorption"/>
            <pathway-xref db="Reactome" id="R-SPO-196757" name="Metabolism of folate and pterines"/>
            <pathway-xref db="MetaCyc" id="PWY-6322" name="phosphinothricin tripeptide biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-8981373" name="Intestinal hexose absorption"/>
            <pathway-xref db="Reactome" id="R-CEL-429593" name="Inositol transporters"/>
            <pathway-xref db="Reactome" id="R-MMU-5653890" name="Lactose synthesis"/>
            <pathway-xref db="Reactome" id="R-SPO-181429" name="Serotonin Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-264642" name="Acetylcholine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-BTA-442660" name="Na+/Cl- dependent neurotransmitter transporters"/>
            <pathway-xref db="Reactome" id="R-XTR-189200" name="Cellular hexose transport"/>
            <pathway-xref db="Reactome" id="R-HSA-70263" name="Gluconeogenesis"/>
            <pathway-xref db="Reactome" id="R-HSA-5662702" name="Melanin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-549127" name="Organic cation transport"/>
            <pathway-xref db="Reactome" id="R-HSA-210991" name="Basigin interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-5619110" name="Defective SLCO1B1 causes hyperbilirubinemia, Rotor type (HBLRR)"/>
            <pathway-xref db="Reactome" id="R-XTR-210500" name="Glutamate Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-422356" name="Regulation of insulin secretion"/>
            <pathway-xref db="Reactome" id="R-HSA-429593" name="Inositol transporters"/>
            <pathway-xref db="Reactome" id="R-SPO-429593" name="Inositol transporters"/>
            <pathway-xref db="Reactome" id="R-GGA-352832" name="Glucose transport"/>
            <pathway-xref db="Reactome" id="R-HSA-1660661" name="Sphingolipid de novo biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-5619061" name="Defective SLC33A1 causes spastic paraplegia 42 (SPG42)"/>
            <pathway-xref db="Reactome" id="R-DME-879518" name="Transport of organic anions"/>
            <pathway-xref db="Reactome" id="R-MMU-210500" name="Glutamate Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-210991" name="Basigin interactions"/>
            <pathway-xref db="Reactome" id="R-BTA-549127" name="Organic cation transport"/>
            <pathway-xref db="Reactome" id="R-HSA-351906" name="Apoptotic cleavage of cell adhesion proteins"/>
            <pathway-xref db="Reactome" id="R-MMU-442660" name="Na+/Cl- dependent neurotransmitter transporters"/>
            <pathway-xref db="Reactome" id="R-RNO-212676" name="Dopamine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-SCE-196836" name="Vitamin C (ascorbate) metabolism"/>
            <pathway-xref db="Reactome" id="R-CEL-197264" name="Nicotinamide salvaging"/>
            <pathway-xref db="MetaCyc" id="PWY-7740" name="beta-D-mannosyl phosphomycoketide biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-200425" name="Carnitine metabolism"/>
            <pathway-xref db="Reactome" id="R-SPO-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-RNO-429593" name="Inositol transporters"/>
            <pathway-xref db="Reactome" id="R-RNO-422356" name="Regulation of insulin secretion"/>
            <pathway-xref db="Reactome" id="R-MMU-427975" name="Proton/oligopeptide cotransporters"/>
            <pathway-xref db="Reactome" id="R-RNO-181429" name="Serotonin Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-917937" name="Iron uptake and transport"/>
            <pathway-xref db="Reactome" id="R-HSA-5619043" name="Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1)"/>
            <pathway-xref db="Reactome" id="R-HSA-5619060" name="Defective CP causes aceruloplasminemia (ACERULOP)"/>
            <pathway-xref db="Reactome" id="R-MMU-196757" name="Metabolism of folate and pterines"/>
            <pathway-xref db="Reactome" id="R-SCE-5653890" name="Lactose synthesis"/>
            <pathway-xref db="Reactome" id="R-SCE-352230" name="Amino acid transport across the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-HSA-264642" name="Acetylcholine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-8856828" name="Clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-RNO-181430" name="Norepinephrine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-DRE-425410" name="Metal ion SLC transporters"/>
            <pathway-xref db="Reactome" id="R-MMU-879518" name="Transport of organic anions"/>
            <pathway-xref db="MetaCyc" id="PWY-5129" name="sphingolipid biosynthesis (plants)"/>
            <pathway-xref db="Reactome" id="R-RNO-112311" name="Neurotransmitter clearance"/>
            <pathway-xref db="Reactome" id="R-HSA-5619053" name="Defective SLC22A5 causes systemic primary carnitine deficiency (CDSP)"/>
            <pathway-xref db="Reactome" id="R-DRE-1660661" name="Sphingolipid de novo biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-189483" name="Heme degradation"/>
            <pathway-xref db="Reactome" id="R-CEL-561048" name="Organic anion transport"/>
            <pathway-xref db="Reactome" id="R-HSA-5250955" name="Toxicity of botulinum toxin type D (botD)"/>
            <pathway-xref db="Reactome" id="R-MMU-196819" name="Vitamin B1 (thiamin) metabolism"/>
            <pathway-xref db="Reactome" id="R-RNO-9707616" name="Heme signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-1660661" name="Sphingolipid de novo biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9707616" name="Heme signaling"/>
            <pathway-xref db="Reactome" id="R-BTA-196757" name="Metabolism of folate and pterines"/>
            <pathway-xref db="MetaCyc" id="PWY-7886" name="cell-surface glycoconjugate-linked phosphocholine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SSC-561048" name="Organic anion transport"/>
            <pathway-xref db="Reactome" id="R-DME-189200" name="Cellular hexose transport"/>
            <pathway-xref db="Reactome" id="R-SPO-189200" name="Cellular hexose transport"/>
            <pathway-xref db="Reactome" id="R-HSA-2161517" name="Abacavir transmembrane transport"/>
            <pathway-xref db="Reactome" id="R-MMU-425397" name="Transport of vitamins, nucleosides, and related molecules"/>
            <pathway-xref db="Reactome" id="R-DRE-561048" name="Organic anion transport"/>
            <pathway-xref db="Reactome" id="R-SCE-189200" name="Cellular hexose transport"/>
            <pathway-xref db="Reactome" id="R-DME-8856828" name="Clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-RNO-2161517" name="Abacavir transmembrane transport"/>
            <pathway-xref db="Reactome" id="R-HSA-196836" name="Vitamin C (ascorbate) metabolism"/>
            <pathway-xref db="Reactome" id="R-HSA-189200" name="Cellular hexose transport"/>
            <pathway-xref db="Reactome" id="R-HSA-5619047" name="Defective SLC2A9 causes hypouricemia renal 2 (RHUC2)"/>
            <pathway-xref db="Reactome" id="R-HSA-196757" name="Metabolism of folate and pterines"/>
            <pathway-xref db="Reactome" id="R-SPO-9707616" name="Heme signaling"/>
            <pathway-xref db="Reactome" id="R-SPO-427975" name="Proton/oligopeptide cotransporters"/>
            <pathway-xref db="Reactome" id="R-SPO-352230" name="Amino acid transport across the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-BTA-879518" name="Transport of organic anions"/>
            <pathway-xref db="Reactome" id="R-HSA-425410" name="Metal ion SLC transporters"/>
            <pathway-xref db="Reactome" id="R-RNO-428643" name="Organic anion transporters"/>
            <pathway-xref db="Reactome" id="R-HSA-3229133" name="Glycogen storage disease type Ib (SLC37A4)"/>
            <pathway-xref db="Reactome" id="R-DME-8981373" name="Intestinal hexose absorption"/>
            <pathway-xref db="Reactome" id="R-DRE-83936" name="Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-SCE-83936" name="Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-HSA-425397" name="Transport of vitamins, nucleosides, and related molecules"/>
            <pathway-xref db="Reactome" id="R-HSA-879518" name="Transport of organic anions"/>
            <pathway-xref db="Reactome" id="R-SCE-9707616" name="Heme signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-SSC-422356" name="Regulation of insulin secretion"/>
            <pathway-xref db="Reactome" id="R-MMU-112311" name="Neurotransmitter clearance"/>
            <pathway-xref db="Reactome" id="R-HSA-159418" name="Recycling of bile acids and salts"/>
            <pathway-xref db="Reactome" id="R-SCE-425397" name="Transport of vitamins, nucleosides, and related molecules"/>
            <pathway-xref db="Reactome" id="R-DDI-196819" name="Vitamin B1 (thiamin) metabolism"/>
            <pathway-xref db="Reactome" id="R-HSA-5619076" name="Defective SLC17A8 causes autosomal dominant deafness 25 (DFNA25)"/>
            <pathway-xref db="Reactome" id="R-SPO-442660" name="Na+/Cl- dependent neurotransmitter transporters"/>
            <pathway-xref db="Reactome" id="R-DME-264642" name="Acetylcholine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-9022699" name="MECP2 regulates neuronal receptors and channels"/>
            <pathway-xref db="Reactome" id="R-MMU-4085001" name="Sialic acid metabolism"/>
            <pathway-xref db="Reactome" id="R-BTA-189200" name="Cellular hexose transport"/>
            <pathway-xref db="Reactome" id="R-HSA-181429" name="Serotonin Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-2672351" name="Stimuli-sensing channels"/>
            <pathway-xref db="Reactome" id="R-RNO-561048" name="Organic anion transport"/>
            <pathway-xref db="Reactome" id="R-HSA-70268" name="Pyruvate metabolism"/>
            <pathway-xref db="Reactome" id="R-HSA-5619070" name="Defective SLC16A1 causes symptomatic deficiency in lactate transport (SDLT)"/>
            <pathway-xref db="Reactome" id="R-HSA-917937" name="Iron uptake and transport"/>
            <pathway-xref db="Reactome" id="R-DRE-264642" name="Acetylcholine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-197264" name="Nicotinamide salvaging"/>
            <pathway-xref db="Reactome" id="R-HSA-8856828" name="Clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-HSA-5250992" name="Toxicity of botulinum toxin type E (botE)"/>
            <pathway-xref db="Reactome" id="R-HSA-433692" name="Proton-coupled monocarboxylate transport"/>
            <pathway-xref db="Reactome" id="R-HSA-8981373" name="Intestinal hexose absorption"/>
            <pathway-xref db="Reactome" id="R-HSA-189451" name="Heme biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-427975" name="Proton/oligopeptide cotransporters"/>
            <pathway-xref db="Reactome" id="R-HSA-5250968" name="Toxicity of botulinum toxin type A (botA)"/>
            <pathway-xref db="Reactome" id="R-MMU-549127" name="Organic cation transport"/>
            <pathway-xref db="Reactome" id="R-RNO-442660" name="Na+/Cl- dependent neurotransmitter transporters"/>
            <pathway-xref db="Reactome" id="R-CEL-422356" name="Regulation of insulin secretion"/>
            <pathway-xref db="Reactome" id="R-HSA-112311" name="Neurotransmitter clearance"/>
            <pathway-xref db="Reactome" id="R-HSA-5619071" name="Defective SLC22A12 causes renal hypouricemia 1 (RHUC1)"/>
            <pathway-xref db="Reactome" id="R-RNO-196836" name="Vitamin C (ascorbate) metabolism"/>
            <pathway-xref db="Reactome" id="R-SCE-422356" name="Regulation of insulin secretion"/>
            <pathway-xref db="Reactome" id="R-MMU-189200" name="Cellular hexose transport"/>
            <pathway-xref db="Reactome" id="R-HSA-5619035" name="Defective SLC17A5 causes Salla disease (SD) and ISSD"/>
            <pathway-xref db="Reactome" id="R-MMU-1483191" name="Synthesis of PC"/>
            <pathway-xref db="Reactome" id="R-XTR-352230" name="Amino acid transport across the plasma membrane"/>
            <pathway-xref db="MetaCyc" id="PWY-6955" name="lincomycin A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DRE-196757" name="Metabolism of folate and pterines"/>
            <pathway-xref db="Reactome" id="R-MMU-425410" name="Metal ion SLC transporters"/>
            <pathway-xref db="Reactome" id="R-SSC-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="MetaCyc" id="PWY-7769" name="phosalacine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-200425" name="Carnitine metabolism"/>
            <pathway-xref db="Reactome" id="R-HSA-381340" name="Transcriptional regulation of white adipocyte differentiation"/>
            <pathway-xref db="Reactome" id="R-HSA-8935964" name="RUNX1 regulates expression of components of tight junctions"/>
            <pathway-xref db="Reactome" id="R-CEL-428643" name="Organic anion transporters"/>
            <pathway-xref db="Reactome" id="R-MMU-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-RNO-427975" name="Proton/oligopeptide cotransporters"/>
            <pathway-xref db="Reactome" id="R-DRE-9707616" name="Heme signaling"/>
            <pathway-xref db="Reactome" id="R-SCE-879518" name="Transport of organic anions"/>
            <pathway-xref db="Reactome" id="R-DME-1660661" name="Sphingolipid de novo biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7077" name="N-acetyl-D-galactosamine degradation"/>
            <pathway-xref db="Reactome" id="R-SCE-196757" name="Metabolism of folate and pterines"/>
            <pathway-xref db="Reactome" id="R-HSA-4085001" name="Sialic acid metabolism"/>
            <pathway-xref db="Reactome" id="R-MMU-70263" name="Gluconeogenesis"/>
            <pathway-xref db="Reactome" id="R-SCE-917937" name="Iron uptake and transport"/>
            <pathway-xref db="Reactome" id="R-CEL-196819" name="Vitamin B1 (thiamin) metabolism"/>
            <pathway-xref db="Reactome" id="R-RNO-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-MMU-8856828" name="Clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-DRE-70263" name="Gluconeogenesis"/>
            <pathway-xref db="Reactome" id="R-DRE-917937" name="Iron uptake and transport"/>
            <pathway-xref db="Reactome" id="R-RNO-189483" name="Heme degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-9662360" name="Sensory processing of sound by inner hair cells of the cochlea"/>
            <pathway-xref db="MetaCyc" id="PWY-6369" name="inositol diphosphates biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-5619068" name="Defective SLC2A10 causes arterial tortuosity syndrome (ATS)"/>
            <pathway-xref db="Reactome" id="R-RNO-8981373" name="Intestinal hexose absorption"/>
            <pathway-xref db="Reactome" id="R-MMU-83936" name="Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-SSC-196836" name="Vitamin C (ascorbate) metabolism"/>
            <pathway-xref db="Reactome" id="R-HSA-200425" name="Carnitine metabolism"/>
            <pathway-xref db="Reactome" id="R-MMU-433692" name="Proton-coupled monocarboxylate transport"/>
            <pathway-xref db="Reactome" id="R-XTR-70263" name="Gluconeogenesis"/>
            <pathway-xref db="Reactome" id="R-HSA-197264" name="Nicotinamide salvaging"/>
            <pathway-xref db="Reactome" id="R-RNO-70268" name="Pyruvate metabolism"/>
            <pathway-xref db="Reactome" id="R-MMU-181429" name="Serotonin Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-BTA-9707616" name="Heme signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-196836" name="Vitamin C (ascorbate) metabolism"/>
            <pathway-xref db="Reactome" id="R-MMU-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-CEL-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-BTA-2161517" name="Abacavir transmembrane transport"/>
            <pathway-xref db="Reactome" id="R-HSA-1483191" name="Synthesis of PC"/>
            <pathway-xref db="Reactome" id="R-HSA-210745" name="Regulation of gene expression in beta cells"/>
            <pathway-xref db="Reactome" id="R-HSA-9636383" name="Prevention of phagosomal-lysosomal fusion"/>
            <pathway-xref db="Reactome" id="R-RNO-549127" name="Organic cation transport"/>
            <pathway-xref db="Reactome" id="R-HSA-5619098" name="Defective SLC2A2 causes Fanconi-Bickel syndrome (FBS)"/>
            <pathway-xref db="Reactome" id="R-SPO-181430" name="Norepinephrine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-5619066" name="Defective SLC22A18 causes lung cancer (LNCR) and embryonal rhabdomyosarcoma 1 (RMSE1)"/>
            <pathway-xref db="Reactome" id="R-HSA-5250981" name="Toxicity of botulinum toxin type F (botF)"/>
            <pathway-xref db="MetaCyc" id="PWY-8129" name="cell-surface glycoconjugate-linked phosphonate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-189483" name="Heme degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-5662702" name="Melanin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-264642" name="Acetylcholine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-1445148" name="Translocation of SLC2A4 (GLUT4) to the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-HSA-212676" name="Dopamine Neurotransmitter Release Cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-7884" name="lipoprotein posttranslational modification"/>
            <pathway-xref db="Reactome" id="R-HSA-83936" name="Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-MMU-210991" name="Basigin interactions"/>
            <pathway-xref db="Reactome" id="R-MMU-159418" name="Recycling of bile acids and salts"/>
            <pathway-xref db="Reactome" id="R-SCE-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="MetaCyc" id="PWY-6682" name="dehydrophos biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-561048" name="Organic anion transport"/>
            <pathway-xref db="Reactome" id="R-MMU-429593" name="Inositol transporters"/>
            <pathway-xref db="Reactome" id="R-DME-197264" name="Nicotinamide salvaging"/>
            <pathway-xref db="Reactome" id="R-SCE-427975" name="Proton/oligopeptide cotransporters"/>
            <pathway-xref db="Reactome" id="R-BTA-917937" name="Iron uptake and transport"/>
            <pathway-xref db="Reactome" id="R-CEL-549127" name="Organic cation transport"/>
            <pathway-xref db="Reactome" id="R-CEL-189200" name="Cellular hexose transport"/>
            <pathway-xref db="Reactome" id="R-HSA-210500" name="Glutamate Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-5653890" name="Lactose synthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-442660" name="Na+/Cl- dependent neurotransmitter transporters"/>
            <pathway-xref db="Reactome" id="R-BTA-112311" name="Neurotransmitter clearance"/>
            <pathway-xref db="MetaCyc" id="PWY-7948" name="4-oxopentanoate degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-5619058" name="Defective SLCO1B3 causes hyperbilirubinemia, Rotor type (HBLRR)"/>
            <pathway-xref db="Reactome" id="R-XTR-428643" name="Organic anion transporters"/>
            <pathway-xref db="MetaCyc" id="PWY-7321" name="ecdysteroid metabolism (arthropods)"/>
            <pathway-xref db="Reactome" id="R-DME-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-RNO-352230" name="Amino acid transport across the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-RNO-83936" name="Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane"/>
            <pathway-xref db="MetaCyc" id="PWY-6626" name="cytidine-5'-diphosphate-glycerol biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-MMU-917937" name="Iron uptake and transport"/>
            <pathway-xref db="Reactome" id="R-SSC-189200" name="Cellular hexose transport"/>
            <pathway-xref db="Reactome" id="R-MMU-8981373" name="Intestinal hexose absorption"/>
            <pathway-xref db="Reactome" id="R-MMU-422356" name="Regulation of insulin secretion"/>
            <pathway-xref db="Reactome" id="R-SPO-212676" name="Dopamine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-428643" name="Organic anion transporters"/>
            <pathway-xref db="Reactome" id="R-DRE-189200" name="Cellular hexose transport"/>
            <pathway-xref db="Reactome" id="R-CEL-8856828" name="Clathrin-mediated endocytosis"/>
          </entry>
          <signature-library-release library="SUPERFAMILY" version="1.75"/>
        </signature>
        <model-ac>0042501</model-ac>
        <locations>
          <superfamilyhmmer3-location hmm-length="447" start="156" end="538">
            <location-fragments>
              <superfamilyhmmer3-location-fragment start="156" end="538" dc-status="CONTINUOUS"/>
            </location-fragments>
          </superfamilyhmmer3-location>
        </locations>
      </superfamilyhmmer3-match>
    </matches>
  </protein>
  <protein>
    <sequence md5="bb76e6fa07f332e608bc07e78b1af7e9">DMLCERVFAPPLGPASLVHGTSLAKVKRKADFHIDIKQEPVDSVRFSFADFELSSIPTTPGGHLQVPPLTPLTNKKVGEALKLTYSSWSERAENEEIPPNPRDWTPRHVSLWLDWTMREFSLESDTFKDFLKSFQLSGSEMCALSKESFMDQAPRCVGDILYEHLQLLLQQDPIALVSTTTQEIGSGGGQEITLTTRLSPSLSIYDPVHHTQPFFPSSIGQDAYARIHAFSSTASQSPMEFFPASPSVLQPTPPSLSSSSGVVSLGQTLCSNGIPGMPSFNLDPGFDSPIMGRGMDMGMRGGGSHTPPSTGRMTPAMGSAGPIQLWQFLLELLSDKSCQSFISWTGNDWEFKMANPDEVARRWGIRKNKPKMNYEKLSRGLRYYYDKQIIQKTAGKRYVYRFVCNLETILGCDPKKYFSLIGINPVGGNDSD</sequence>
    <xref id="TCALIF_00911-PA" name="TCALIF_00911-PA protein Name:&quot;Similar to ETS2 Protein C-ets-2 (Bos taurus)&quot; AED:0.21 eAED:0.23 QI:0|0|0|0.8|0.75|0.8|5|0|432"/>
    <matches>
      <fingerprints-match evalue="1.7E-29" graphscan="IIII">
        <signature ac="PR00454" desc="ETS domain signature" name="ETSDOMAIN">
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            <go-xref category="MOLECULAR_FUNCTION" db="GO" id="GO:0003700" name="DNA-binding transcription factor activity"/>
            <go-xref category="MOLECULAR_FUNCTION" db="GO" id="GO:0043565" name="sequence-specific DNA binding"/>
            <go-xref category="BIOLOGICAL_PROCESS" db="GO" id="GO:0006355" name="regulation of transcription, DNA-templated"/>
            <pathway-xref db="Reactome" id="R-DME-2559585" name="Oncogene Induced Senescence"/>
            <pathway-xref db="Reactome" id="R-RNO-2559585" name="Oncogene Induced Senescence"/>
            <pathway-xref db="Reactome" id="R-HSA-9673768" name="Signaling by membrane-tethered fusions of PDGFRA or PDGFRB"/>
            <pathway-xref db="Reactome" id="R-MMU-2559585" name="Oncogene Induced Senescence"/>
            <pathway-xref db="Reactome" id="R-HSA-198753" name="ERK/MAPK targets"/>
            <pathway-xref db="Reactome" id="R-HSA-9703465" name="Signaling by FLT3 fusion proteins"/>
            <pathway-xref db="Reactome" id="R-HSA-2559585" name="Oncogene Induced Senescence"/>
            <pathway-xref db="Reactome" id="R-DME-2151201" name="Transcriptional activation of mitochondrial biogenesis"/>
            <pathway-xref db="Reactome" id="R-DRE-5687128" name="MAPK6/MAPK4 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-8939247" name="RUNX1 regulates transcription of genes involved in interleukin signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-2151201" name="Transcriptional activation of mitochondrial biogenesis"/>
            <pathway-xref db="Reactome" id="R-RNO-1912408" name="Pre-NOTCH Transcription and Translation"/>
            <pathway-xref db="Reactome" id="R-HSA-8939236" name="RUNX1 regulates transcription of genes involved in differentiation of HSCs"/>
            <pathway-xref db="Reactome" id="R-HSA-8939247" name="RUNX1 regulates transcription of genes involved in interleukin signaling"/>
            <pathway-xref db="Reactome" id="R-DME-8939245" name="RUNX1 regulates transcription of genes involved in BCR signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-1912408" name="Pre-NOTCH Transcription and Translation"/>
            <pathway-xref db="Reactome" id="R-HSA-9616222" name="Transcriptional regulation of granulopoiesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9609690" name="HCMV Early Events"/>
            <pathway-xref db="Reactome" id="R-HSA-8939245" name="RUNX1 regulates transcription of genes involved in BCR signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9634638" name="Estrogen-dependent nuclear events downstream of ESR-membrane signaling"/>
            <pathway-xref db="Reactome" id="R-DME-8939247" name="RUNX1 regulates transcription of genes involved in interleukin signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-2151201" name="Transcriptional activation of mitochondrial biogenesis"/>
            <pathway-xref db="Reactome" id="R-MMU-8939245" name="RUNX1 regulates transcription of genes involved in BCR signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9031628" name="NGF-stimulated transcription"/>
            <pathway-xref db="Reactome" id="R-HSA-5687128" name="MAPK6/MAPK4 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-5687128" name="MAPK6/MAPK4 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-1912408" name="Pre-NOTCH Transcription and Translation"/>
            <pathway-xref db="Reactome" id="R-DME-5687128" name="MAPK6/MAPK4 signaling"/>
            <pathway-xref db="Reactome" id="R-GGA-2559585" name="Oncogene Induced Senescence"/>
          </entry>
          <signature-library-release library="PRINTS" version="42.0"/>
        </signature>
        <model-ac>PR00454</model-ac>
        <locations>
          <fingerprints-location motifNumber="3" pvalue="1.83E-12" score="73.05" start="366" end="384">
            <location-fragments>
              <fingerprints-location-fragment start="366" end="384" dc-status="CONTINUOUS"/>
            </location-fragments>
          </fingerprints-location>
          <fingerprints-location motifNumber="4" pvalue="3.54E-10" score="51.62" start="385" end="403">
            <location-fragments>
              <fingerprints-location-fragment start="385" end="403" dc-status="CONTINUOUS"/>
            </location-fragments>
          </fingerprints-location>
          <fingerprints-location motifNumber="2" pvalue="1.6E-7" score="46.02" start="347" end="365">
            <location-fragments>
              <fingerprints-location-fragment start="347" end="365" dc-status="CONTINUOUS"/>
            </location-fragments>
          </fingerprints-location>
          <fingerprints-location motifNumber="1" pvalue="1.37E-7" score="67.2" start="323" end="336">
            <location-fragments>
              <fingerprints-location-fragment start="323" end="336" dc-status="CONTINUOUS"/>
            </location-fragments>
          </fingerprints-location>
        </locations>
      </fingerprints-match>
      <hmmer2-match evalue="4.5E-56" score="202.3">
        <signature ac="SM00413" name="etsneu2">
          <entry ac="IPR000418" desc="Ets domain" name="Ets_dom" type="DOMAIN">
            <go-xref category="MOLECULAR_FUNCTION" db="GO" id="GO:0003700" name="DNA-binding transcription factor activity"/>
            <go-xref category="MOLECULAR_FUNCTION" db="GO" id="GO:0043565" name="sequence-specific DNA binding"/>
            <go-xref category="BIOLOGICAL_PROCESS" db="GO" id="GO:0006355" name="regulation of transcription, DNA-templated"/>
            <pathway-xref db="Reactome" id="R-DME-2559585" name="Oncogene Induced Senescence"/>
            <pathway-xref db="Reactome" id="R-RNO-2559585" name="Oncogene Induced Senescence"/>
            <pathway-xref db="Reactome" id="R-HSA-9673768" name="Signaling by membrane-tethered fusions of PDGFRA or PDGFRB"/>
            <pathway-xref db="Reactome" id="R-MMU-2559585" name="Oncogene Induced Senescence"/>
            <pathway-xref db="Reactome" id="R-HSA-198753" name="ERK/MAPK targets"/>
            <pathway-xref db="Reactome" id="R-HSA-9703465" name="Signaling by FLT3 fusion proteins"/>
            <pathway-xref db="Reactome" id="R-HSA-2559585" name="Oncogene Induced Senescence"/>
            <pathway-xref db="Reactome" id="R-DME-2151201" name="Transcriptional activation of mitochondrial biogenesis"/>
            <pathway-xref db="Reactome" id="R-DRE-5687128" name="MAPK6/MAPK4 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-8939247" name="RUNX1 regulates transcription of genes involved in interleukin signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-2151201" name="Transcriptional activation of mitochondrial biogenesis"/>
            <pathway-xref db="Reactome" id="R-RNO-1912408" name="Pre-NOTCH Transcription and Translation"/>
            <pathway-xref db="Reactome" id="R-HSA-8939236" name="RUNX1 regulates transcription of genes involved in differentiation of HSCs"/>
            <pathway-xref db="Reactome" id="R-HSA-8939247" name="RUNX1 regulates transcription of genes involved in interleukin signaling"/>
            <pathway-xref db="Reactome" id="R-DME-8939245" name="RUNX1 regulates transcription of genes involved in BCR signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-1912408" name="Pre-NOTCH Transcription and Translation"/>
            <pathway-xref db="Reactome" id="R-HSA-9616222" name="Transcriptional regulation of granulopoiesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9609690" name="HCMV Early Events"/>
            <pathway-xref db="Reactome" id="R-HSA-8939245" name="RUNX1 regulates transcription of genes involved in BCR signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9634638" name="Estrogen-dependent nuclear events downstream of ESR-membrane signaling"/>
            <pathway-xref db="Reactome" id="R-DME-8939247" name="RUNX1 regulates transcription of genes involved in interleukin signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-2151201" name="Transcriptional activation of mitochondrial biogenesis"/>
            <pathway-xref db="Reactome" id="R-MMU-8939245" name="RUNX1 regulates transcription of genes involved in BCR signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9031628" name="NGF-stimulated transcription"/>
            <pathway-xref db="Reactome" id="R-HSA-5687128" name="MAPK6/MAPK4 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-5687128" name="MAPK6/MAPK4 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-1912408" name="Pre-NOTCH Transcription and Translation"/>
            <pathway-xref db="Reactome" id="R-DME-5687128" name="MAPK6/MAPK4 signaling"/>
            <pathway-xref db="Reactome" id="R-GGA-2559585" name="Oncogene Induced Senescence"/>
          </entry>
          <signature-library-release library="SMART" version="7.1"/>
        </signature>
        <model-ac>SM00413</model-ac>
        <locations>
          <hmmer2-location score="202.3" evalue="4.5E-56" hmm-start="1" hmm-end="90" hmm-length="90" hmm-bounds="COMPLETE" start="322" end="407">
            <location-fragments>
              <hmmer2-location-fragment start="322" end="407" dc-status="CONTINUOUS"/>
            </location-fragments>
          </hmmer2-location>
        </locations>
      </hmmer2-match>
      <hmmer2-match evalue="5.5E-18" score="75.8">
        <signature ac="SM00251" name="SAM2_3">
          <entry ac="IPR003118" desc="Pointed domain" name="Pointed_dom" type="DOMAIN">
            <go-xref category="MOLECULAR_FUNCTION" db="GO" id="GO:0043565" name="sequence-specific DNA binding"/>
            <pathway-xref db="Reactome" id="R-RNO-1912408" name="Pre-NOTCH Transcription and Translation"/>
            <pathway-xref db="Reactome" id="R-DME-2559585" name="Oncogene Induced Senescence"/>
            <pathway-xref db="Reactome" id="R-DME-8939245" name="RUNX1 regulates transcription of genes involved in BCR signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9616222" name="Transcriptional regulation of granulopoiesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9673768" name="Signaling by membrane-tethered fusions of PDGFRA or PDGFRB"/>
            <pathway-xref db="Reactome" id="R-RNO-2559585" name="Oncogene Induced Senescence"/>
            <pathway-xref db="Reactome" id="R-HSA-1912408" name="Pre-NOTCH Transcription and Translation"/>
            <pathway-xref db="Reactome" id="R-MMU-2559585" name="Oncogene Induced Senescence"/>
            <pathway-xref db="Reactome" id="R-HSA-2151201" name="Transcriptional activation of mitochondrial biogenesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9703465" name="Signaling by FLT3 fusion proteins"/>
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            <pathway-xref db="Reactome" id="R-DME-2151201" name="Transcriptional activation of mitochondrial biogenesis"/>
            <pathway-xref db="Reactome" id="R-MMU-1912408" name="Pre-NOTCH Transcription and Translation"/>
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            <pathway-xref db="Reactome" id="R-MMU-2151201" name="Transcriptional activation of mitochondrial biogenesis"/>
          </entry>
          <signature-library-release library="SMART" version="7.1"/>
        </signature>
        <model-ac>SM00251</model-ac>
        <locations>
          <hmmer2-location score="75.8" evalue="5.5E-18" hmm-start="1" hmm-end="90" hmm-length="90" hmm-bounds="COMPLETE" start="85" end="172">
            <location-fragments>
              <hmmer2-location-fragment start="85" end="172" dc-status="CONTINUOUS"/>
            </location-fragments>
          </hmmer2-location>
        </locations>
      </hmmer2-match>
      <hmmer3-match evalue="1.2E-48" score="166.2">
        <signature ac="G3DSA:1.10.10.10" name="">
          <entry ac="IPR036388" desc="Winged helix-like DNA-binding domain superfamily" name="WH-like_DNA-bd_sf" type="HOMOLOGOUS_SUPERFAMILY">
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            <pathway-xref db="Reactome" id="R-CEL-6804116" name="TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest"/>
            <pathway-xref db="Reactome" id="R-DME-674695" name="RNA Polymerase II Pre-transcription Events"/>
            <pathway-xref db="Reactome" id="R-HSA-113418" name="Formation of the Early Elongation Complex"/>
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            <pathway-xref db="Reactome" id="R-HSA-2565942" name="Regulation of PLK1 Activity at G2/M Transition"/>
            <pathway-xref db="Reactome" id="R-DME-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-MMU-72203" name="Processing of Capped Intron-Containing Pre-mRNA"/>
            <pathway-xref db="Reactome" id="R-BTA-936964" name="Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon"/>
            <pathway-xref db="Reactome" id="R-DME-211163" name="AKT-mediated inactivation of FOXO1A"/>
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            <pathway-xref db="MetaCyc" id="PWY-7629" name="yatein biosynthesis II"/>
            <pathway-xref db="MetaCyc" id="PWY-6973" name="dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7049" name="icosapentaenoate biosynthesis II (6-desaturase, mammals)"/>
            <pathway-xref db="Reactome" id="R-MMU-6791226" name="Major pathway of rRNA processing in the nucleolus and cytosol"/>
            <pathway-xref db="Reactome" id="R-SCE-110312" name="Translesion synthesis by REV1"/>
            <pathway-xref db="Reactome" id="R-MMU-75102" name="C6 deamination of adenosine"/>
            <pathway-xref db="Reactome" id="R-HSA-2559586" name="DNA Damage/Telomere Stress Induced Senescence"/>
            <pathway-xref db="Reactome" id="R-MMU-2559586" name="DNA Damage/Telomere Stress Induced Senescence"/>
            <pathway-xref db="Reactome" id="R-HSA-5693616" name="Presynaptic phase of homologous DNA pairing and strand exchange"/>
            <pathway-xref db="Reactome" id="R-CEL-9018519" name="Estrogen-dependent gene expression"/>
            <pathway-xref db="Reactome" id="R-BTA-113418" name="Formation of the Early Elongation Complex"/>
            <pathway-xref db="Reactome" id="R-DME-4608870" name="Asymmetric localization of PCP proteins"/>
            <pathway-xref db="MetaCyc" id="PWY-7631" name="arctigenin and isoarctigenin biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-RNO-6796648" name="TP53 Regulates Transcription of DNA Repair Genes"/>
            <pathway-xref db="Reactome" id="R-MMU-1502540" name="Signaling by Activin"/>
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            <pathway-xref db="Reactome" id="R-MMU-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
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            <pathway-xref db="Reactome" id="R-RNO-75102" name="C6 deamination of adenosine"/>
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            <pathway-xref db="Reactome" id="R-DDI-76042" name="RNA Polymerase II Transcription Initiation And Promoter Clearance"/>
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            <pathway-xref db="Reactome" id="R-CEL-2028269" name="Signaling by Hippo"/>
            <pathway-xref db="Reactome" id="R-RNO-5693579" name="Homologous DNA Pairing and Strand Exchange"/>
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            <pathway-xref db="MetaCyc" id="PWY-5882" name="epoxypseudoisoeugenol-2-methylbutanoate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7402" name="benzoate fermentation (to acetate and cyclohexane carboxylate)"/>
            <pathway-xref db="Reactome" id="R-XTR-5663220" name="RHO GTPases Activate Formins"/>
            <pathway-xref db="Reactome" id="R-HSA-9661069" name="Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)"/>
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            <pathway-xref db="MetaCyc" id="PWY-7301" name="dTDP-4-O-demethyl-beta-L-noviose biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-DDI-2514859" name="Inactivation, recovery and regulation of the phototransduction cascade"/>
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            <pathway-xref db="MetaCyc" id="PWY-6976" name="dTDP-beta-L-mycarose biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7696" name="citreoisocoumarin and bikisocoumarin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-9033241" name="Peroxisomal protein import"/>
            <pathway-xref db="Reactome" id="R-HSA-6814122" name="Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"/>
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            <pathway-xref db="Reactome" id="R-RNO-8932339" name="ROS sensing by NFE2L2"/>
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            <pathway-xref db="Reactome" id="R-DME-112382" name="Formation of RNA Pol II elongation complex"/>
            <pathway-xref db="Reactome" id="R-MMU-933541" name="TRAF6 mediated IRF7 activation"/>
            <pathway-xref db="Reactome" id="R-MMU-2871837" name="FCERI mediated NF-kB activation"/>
            <pathway-xref db="Reactome" id="R-SPO-69017" name="CDK-mediated phosphorylation and removal of Cdc6"/>
            <pathway-xref db="Reactome" id="R-XTR-4086400" name="PCP/CE pathway"/>
            <pathway-xref db="Reactome" id="R-RNO-5651801" name="PCNA-Dependent Long Patch Base Excision Repair"/>
            <pathway-xref db="Reactome" id="R-HSA-9617828" name="FOXO-mediated transcription of cell cycle genes"/>
            <pathway-xref db="Reactome" id="R-MMU-68911" name="G2 Phase"/>
            <pathway-xref db="Reactome" id="R-MMU-68962" name="Activation of the pre-replicative complex"/>
            <pathway-xref db="MetaCyc" id="PWY-81" name="toluene degradation to benzoyl-CoA (anaerobic)"/>
            <pathway-xref db="Reactome" id="R-HSA-9617629" name="Regulation of FOXO transcriptional activity by acetylation"/>
            <pathway-xref db="Reactome" id="R-MMU-9617828" name="FOXO-mediated transcription of cell cycle genes"/>
            <pathway-xref db="MetaCyc" id="PWY-7532" name="acetylaszonalenin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-156827" name="L13a-mediated translational silencing of Ceruloplasmin expression"/>
            <pathway-xref db="Reactome" id="R-DDI-75955" name="RNA Polymerase II Transcription Elongation"/>
            <pathway-xref db="MetaCyc" id="PWY-6036" name="cardenolide glucosides biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-68962" name="Activation of the pre-replicative complex"/>
            <pathway-xref db="Reactome" id="R-BTA-975957" name="Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"/>
            <pathway-xref db="Reactome" id="R-SCE-76066" name="RNA Polymerase III Transcription Initiation From Type 2 Promoter"/>
            <pathway-xref db="Reactome" id="R-DDI-6782135" name="Dual incision in TC-NER"/>
            <pathway-xref db="Reactome" id="R-SPO-5656169" name="Termination of translesion DNA synthesis"/>
            <pathway-xref db="Reactome" id="R-DME-450728" name="Inhibition of actin polymerisation"/>
            <pathway-xref db="Reactome" id="R-XTR-5632684" name="Hedgehog 'on' state"/>
            <pathway-xref db="Reactome" id="R-HSA-69166" name="Removal of the Flap Intermediate"/>
            <pathway-xref db="Reactome" id="R-SSC-1606341" name="IRF3 mediated activation of type 1 IFN"/>
            <pathway-xref db="Reactome" id="R-HSA-9013418" name="RHOBTB2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-382556" name="ABC-family proteins mediated transport"/>
            <pathway-xref db="MetaCyc" id="PWY-7671" name="saframycin A biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5661" name="GDP-alpha-D-glucose biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-174437" name="Removal of the Flap Intermediate from the C-strand"/>
            <pathway-xref db="Reactome" id="R-MMU-8932339" name="ROS sensing by NFE2L2"/>
            <pathway-xref db="Reactome" id="R-HSA-9013408" name="RHOG GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-7693" name="guadinomine B biosynthesis"/>
            <pathway-xref db="Reactome" id="R-BTA-3270619" name="IRF3-mediated induction of type I IFN"/>
            <pathway-xref db="Reactome" id="R-HSA-4086400" name="PCP/CE pathway"/>
            <pathway-xref db="Reactome" id="R-RNO-9705462" name="Inactivation of CSF3 (G-CSF) signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-936964" name="Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon"/>
            <pathway-xref db="Reactome" id="R-MMU-9013418" name="RHOBTB2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-CEL-5663220" name="RHO GTPases Activate Formins"/>
            <pathway-xref db="MetaCyc" id="PWY-8166" name="emodin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-72163" name="mRNA Splicing - Major Pathway"/>
            <pathway-xref db="Reactome" id="R-SPO-1236978" name="Cross-presentation of soluble exogenous antigens (endosomes)"/>
            <pathway-xref db="Reactome" id="R-MMU-9013405" name="RHOD GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-69166" name="Removal of the Flap Intermediate"/>
            <pathway-xref db="MetaCyc" id="PWY-7989" name="acinetoferrin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SPO-72649" name="Translation initiation complex formation"/>
            <pathway-xref db="Reactome" id="R-CEL-3214842" name="HDMs demethylate histones"/>
            <pathway-xref db="MetaCyc" id="PWY-6545" name="pyrimidine deoxyribonucleotides de novo biosynthesis III"/>
            <pathway-xref db="MetaCyc" id="PWY-7677" name="rosamicin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-1362277" name="Transcription of E2F targets under negative control by DREAM complex"/>
            <pathway-xref db="MetaCyc" id="PWY-7261" name="anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)"/>
            <pathway-xref db="Reactome" id="R-HSA-6781827" name="Transcription-Coupled Nucleotide Excision Repair (TC-NER)"/>
            <pathway-xref db="Reactome" id="R-MMU-113418" name="Formation of the Early Elongation Complex"/>
            <pathway-xref db="Reactome" id="R-MMU-69231" name="Cyclin D associated events in G1"/>
            <pathway-xref db="Reactome" id="R-SPO-5687128" name="MAPK6/MAPK4 signaling"/>
            <pathway-xref db="Reactome" id="R-DDI-6782210" name="Gap-filling DNA repair synthesis and ligation in TC-NER"/>
            <pathway-xref db="MetaCyc" id="PWY-6739" name="pinitol biosynthesis II"/>
            <pathway-xref db="Reactome" id="R-HSA-5693571" name="Nonhomologous End-Joining (NHEJ)"/>
            <pathway-xref db="MetaCyc" id="PWY-7480" name="2,3-dihydroxybenzoate degradation"/>
            <pathway-xref db="Reactome" id="R-CEL-8939245" name="RUNX1 regulates transcription of genes involved in BCR signaling"/>
            <pathway-xref db="Reactome" id="R-SSC-918233" name="TRAF3-dependent IRF activation pathway"/>
            <pathway-xref db="Reactome" id="R-MMU-5693571" name="Nonhomologous End-Joining (NHEJ)"/>
            <pathway-xref db="Reactome" id="R-DME-72702" name="Ribosomal scanning and start codon recognition"/>
            <pathway-xref db="Reactome" id="R-DDI-2559582" name="Senescence-Associated Secretory Phenotype (SASP)"/>
            <pathway-xref db="MetaCyc" id="PWY-7112" name="4-hydroxy-2-nonenal detoxification"/>
            <pathway-xref db="MetaCyc" id="PWY-5773" name="gossypol biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DRE-5693568" name="Resolution of D-loop Structures through Holliday Junction Intermediates"/>
            <pathway-xref db="Reactome" id="R-CEL-9013404" name="RAC2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-75955" name="RNA Polymerase II Transcription Elongation"/>
            <pathway-xref db="MetaCyc" id="PWY-7702" name="sch210971 and sch210972 biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-5689603" name="UCH proteinases"/>
            <pathway-xref db="Reactome" id="R-BTA-975956" name="Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"/>
            <pathway-xref db="MetaCyc" id="PWY-5479" name="6-methoxypodophyllotoxin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6154" name="autoinducer AI-2 biosynthesis II (Vibrio)"/>
            <pathway-xref db="Reactome" id="R-DME-9013422" name="RHOBTB1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-8941858" name="Regulation of RUNX3 expression and activity"/>
            <pathway-xref db="Reactome" id="R-HSA-9013148" name="CDC42 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-SPO-72689" name="Formation of a pool of free 40S subunits"/>
            <pathway-xref db="MetaCyc" id="PWY-8125" name="mevalonate pathway IV (archaea)"/>
            <pathway-xref db="Reactome" id="R-HSA-174084" name="Autodegradation of Cdh1 by Cdh1:APC/C"/>
            <pathway-xref db="Reactome" id="R-MMU-6781823" name="Formation of TC-NER Pre-Incision Complex"/>
            <pathway-xref db="Reactome" id="R-SPO-2559586" name="DNA Damage/Telomere Stress Induced Senescence"/>
            <pathway-xref db="MetaCyc" id="PWY-6056" name="dimethylsulfoniopropanoate degradation II (cleavage)"/>
            <pathway-xref db="Reactome" id="R-HSA-168928" name="DDX58/IFIH1-mediated induction of interferon-alpha/beta"/>
            <pathway-xref db="Reactome" id="R-HSA-8932339" name="ROS sensing by NFE2L2"/>
            <pathway-xref db="Reactome" id="R-HSA-1538133" name="G0 and Early G1"/>
            <pathway-xref db="MetaCyc" id="PWY-7452" name="cyanidin dimalonylglucoside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-5610783" name="Degradation of GLI2 by the proteasome"/>
            <pathway-xref db="Reactome" id="R-HSA-6781823" name="Formation of TC-NER Pre-Incision Complex"/>
            <pathway-xref db="Reactome" id="R-DME-3214815" name="HDACs deacetylate histones"/>
            <pathway-xref db="MetaCyc" id="PWY-8038" name="naphthomycin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7055" name="daphnetin modification"/>
            <pathway-xref db="MetaCyc" id="PWY-7737" name="thiocoraline biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-9013148" name="CDC42 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-6807505" name="RNA polymerase II transcribes snRNA genes"/>
            <pathway-xref db="MetaCyc" id="PWY-7458" name="violdelphin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7077" name="N-acetyl-D-galactosamine degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7672" name="fusaric acid biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7529" name="CMP-N-acetyl-7-O-acetylneuraminate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-5696400" name="Dual Incision in GG-NER"/>
            <pathway-xref db="Reactome" id="R-MMU-5689603" name="UCH proteinases"/>
            <pathway-xref db="Reactome" id="R-SCE-6796648" name="TP53 Regulates Transcription of DNA Repair Genes"/>
            <pathway-xref db="Reactome" id="R-DDI-73779" name="RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"/>
            <pathway-xref db="Reactome" id="R-RNO-174411" name="Polymerase switching on the C-strand of the telomere"/>
            <pathway-xref db="Reactome" id="R-DME-5610785" name="GLI3 is processed to GLI3R by the proteasome"/>
            <pathway-xref db="MetaCyc" id="PWY-6369" name="inositol diphosphates biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-75955" name="RNA Polymerase II Transcription Elongation"/>
            <pathway-xref db="Reactome" id="R-DDI-1799339" name="SRP-dependent cotranslational protein targeting to membrane"/>
            <pathway-xref db="Reactome" id="R-MMU-195253" name="Degradation of beta-catenin by the destruction complex"/>
            <pathway-xref db="MetaCyc" id="PWY-6950" name="DIMBOA-glucoside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-3371453" name="Regulation of HSF1-mediated heat shock response"/>
            <pathway-xref db="Reactome" id="R-HSA-167160" name="RNA Pol II CTD phosphorylation and interaction with CE during HIV infection"/>
            <pathway-xref db="Reactome" id="R-SCE-75955" name="RNA Polymerase II Transcription Elongation"/>
            <pathway-xref db="Reactome" id="R-DME-76061" name="RNA Polymerase III Transcription Initiation From Type 1 Promoter"/>
            <pathway-xref db="MetaCyc" id="PWY-5679" name="clavulanate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9013409" name="RHOJ GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-7923" name="archaeosine biosynthesis II"/>
            <pathway-xref db="Reactome" id="R-RNO-5655862" name="Translesion synthesis by POLK"/>
            <pathway-xref db="Reactome" id="R-HSA-5362768" name="Hh mutants are degraded by ERAD"/>
            <pathway-xref db="MetaCyc" id="PWY-7741" name="phthiocerol biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SSC-3134973" name="LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production"/>
            <pathway-xref db="MetaCyc" id="PWY-7511" name="protein ubiquitination"/>
            <pathway-xref db="Reactome" id="R-MMU-1538133" name="G0 and Early G1"/>
            <pathway-xref db="Reactome" id="R-HSA-201688" name="WNT mediated activation of DVL"/>
            <pathway-xref db="Reactome" id="R-HSA-8939256" name="RUNX1 regulates transcription of genes involved in WNT signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-8075" name="(Kdo)2-lipid A biosynthesis (P. putida)"/>
            <pathway-xref db="MetaCyc" id="PWY-7821" name="tunicamycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-174414" name="Processive synthesis on the C-strand of the telomere"/>
            <pathway-xref db="Reactome" id="R-DME-72203" name="Processing of Capped Intron-Containing Pre-mRNA"/>
            <pathway-xref db="MetaCyc" id="PWY-7507" name="chelerythrine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-749476" name="RNA Polymerase III Abortive And Retractive Initiation"/>
            <pathway-xref db="Reactome" id="R-CEL-3371568" name="Attenuation phase"/>
            <pathway-xref db="Reactome" id="R-MMU-75955" name="RNA Polymerase II Transcription Elongation"/>
            <pathway-xref db="MetaCyc" id="PWY-1061" name="homogalacturonan biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-8941858" name="Regulation of RUNX3 expression and activity"/>
            <pathway-xref db="Reactome" id="R-BTA-5696394" name="DNA Damage Recognition in GG-NER"/>
            <pathway-xref db="Reactome" id="R-SCE-3371453" name="Regulation of HSF1-mediated heat shock response"/>
            <pathway-xref db="Reactome" id="R-DME-9607240" name="FLT3 Signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-176408" name="Regulation of APC/C activators between G1/S and early anaphase"/>
            <pathway-xref db="Reactome" id="R-SPO-8854050" name="FBXL7 down-regulates AURKA during mitotic entry and in early mitosis"/>
            <pathway-xref db="Reactome" id="R-HSA-168325" name="Viral Messenger RNA Synthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7265" name="lampranthin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-6803529" name="FGFR2 alternative splicing"/>
            <pathway-xref db="Reactome" id="R-MMU-1170546" name="Prolactin receptor signaling"/>
            <pathway-xref db="Reactome" id="R-SPO-5655862" name="Translesion synthesis by POLK"/>
            <pathway-xref db="Reactome" id="R-SCE-68689" name="CDC6 association with the ORC:origin complex"/>
            <pathway-xref db="Reactome" id="R-HSA-9013406" name="RHOQ GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-1170546" name="Prolactin receptor signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-8104" name="yangonin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7818" name="type IV lipoteichoic acid biosynthesis (S. pneumoniae)"/>
            <pathway-xref db="Reactome" id="R-MMU-1169408" name="ISG15 antiviral mechanism"/>
            <pathway-xref db="Reactome" id="R-MMU-5668541" name="TNFR2 non-canonical NF-kB pathway"/>
            <pathway-xref db="Reactome" id="R-HSA-8939247" name="RUNX1 regulates transcription of genes involved in interleukin signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-76066" name="RNA Polymerase III Transcription Initiation From Type 2 Promoter"/>
            <pathway-xref db="Reactome" id="R-HSA-6796648" name="TP53 Regulates Transcription of DNA Repair Genes"/>
            <pathway-xref db="MetaCyc" id="PWY-7624" name="nystatin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5871" name="ubiquinol-9 biosynthesis (late decarboxylation)"/>
            <pathway-xref db="Reactome" id="R-MMU-350562" name="Regulation of ornithine decarboxylase (ODC)"/>
            <pathway-xref db="MetaCyc" id="PWY-6397" name="mycolyl-arabinogalactan-peptidoglycan complex biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SSC-9013422" name="RHOBTB1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-SCE-3214858" name="RMTs methylate histone arginines"/>
            <pathway-xref db="Reactome" id="R-DME-198693" name="AKT phosphorylates targets in the nucleus"/>
            <pathway-xref db="Reactome" id="R-HSA-9607240" name="FLT3 Signaling"/>
            <pathway-xref db="Reactome" id="R-DDI-1236978" name="Cross-presentation of soluble exogenous antigens (endosomes)"/>
            <pathway-xref db="MetaCyc" id="PWY-7601" name="arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)"/>
            <pathway-xref db="Reactome" id="R-HSA-6803529" name="FGFR2 alternative splicing"/>
            <pathway-xref db="Reactome" id="R-MMU-2467813" name="Separation of Sister Chromatids"/>
            <pathway-xref db="Reactome" id="R-DDI-174084" name="Autodegradation of Cdh1 by Cdh1:APC/C"/>
            <pathway-xref db="Reactome" id="R-DDI-975956" name="Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"/>
            <pathway-xref db="Reactome" id="R-DME-5610780" name="Degradation of GLI1 by the proteasome"/>
            <pathway-xref db="Reactome" id="R-HSA-69473" name="G2/M DNA damage checkpoint"/>
            <pathway-xref db="Reactome" id="R-HSA-6804114" name="TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest"/>
            <pathway-xref db="Reactome" id="R-DDI-76066" name="RNA Polymerase III Transcription Initiation From Type 2 Promoter"/>
            <pathway-xref db="Reactome" id="R-RNO-8951664" name="Neddylation"/>
            <pathway-xref db="Reactome" id="R-HSA-2467813" name="Separation of Sister Chromatids"/>
            <pathway-xref db="MetaCyc" id="PWY-8212" name="Escherichia coli serotype O:8 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-392517" name="Rap1 signalling"/>
            <pathway-xref db="Reactome" id="R-HSA-5668541" name="TNFR2 non-canonical NF-kB pathway"/>
            <pathway-xref db="MetaCyc" id="PWY-7983" name="pseudomonine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-381038" name="XBP1(S) activates chaperone genes"/>
            <pathway-xref db="MetaCyc" id="PWY-5400" name="amaranthin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SCE-1799339" name="SRP-dependent cotranslational protein targeting to membrane"/>
            <pathway-xref db="Reactome" id="R-MMU-5696397" name="Gap-filling DNA repair synthesis and ligation in GG-NER"/>
            <pathway-xref db="Reactome" id="R-SPO-917937" name="Iron uptake and transport"/>
            <pathway-xref db="Reactome" id="R-CEL-156827" name="L13a-mediated translational silencing of Ceruloplasmin expression"/>
            <pathway-xref db="Reactome" id="R-HSA-9639288" name="Amino acids regulate mTORC1"/>
            <pathway-xref db="Reactome" id="R-RNO-6791226" name="Major pathway of rRNA processing in the nucleolus and cytosol"/>
            <pathway-xref db="Reactome" id="R-SCE-72086" name="mRNA Capping"/>
            <pathway-xref db="MetaCyc" id="PWY-6322" name="phosphinothricin tripeptide biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-68911" name="G2 Phase"/>
            <pathway-xref db="Reactome" id="R-HSA-69231" name="Cyclin D associated events in G1"/>
            <pathway-xref db="Reactome" id="R-RNO-111459" name="Activation of caspases through apoptosome-mediated cleavage"/>
            <pathway-xref db="Reactome" id="R-MMU-9607240" name="FLT3 Signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-5710" name="capsaicin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SPO-69601" name="Ubiquitin Mediated Degradation of Phosphorylated Cdc25A"/>
            <pathway-xref db="Reactome" id="R-CEL-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-CEL-9634638" name="Estrogen-dependent nuclear events downstream of ESR-membrane signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-5437" name="L-threonine degradation I"/>
            <pathway-xref db="Reactome" id="R-HSA-202424" name="Downstream TCR signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-7474" name="avenacin A-2 biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-5696395" name="Formation of Incision Complex in GG-NER"/>
            <pathway-xref db="Reactome" id="R-BTA-9013973" name="TICAM1-dependent activation of IRF3/IRF7"/>
            <pathway-xref db="Reactome" id="R-DDI-6803529" name="FGFR2 alternative splicing"/>
            <pathway-xref db="Reactome" id="R-HSA-5685938" name="HDR through Single Strand Annealing (SSA)"/>
            <pathway-xref db="Reactome" id="R-DME-2151201" name="Transcriptional activation of mitochondrial biogenesis"/>
            <pathway-xref db="Reactome" id="R-SPO-72702" name="Ribosomal scanning and start codon recognition"/>
            <pathway-xref db="Reactome" id="R-DDI-9018519" name="Estrogen-dependent gene expression"/>
            <pathway-xref db="MetaCyc" id="PWY-7533" name="gliotoxin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-4086400" name="PCP/CE pathway"/>
            <pathway-xref db="Reactome" id="R-SPO-72165" name="mRNA Splicing - Minor Pathway"/>
            <pathway-xref db="Reactome" id="R-RNO-354192" name="Integrin signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-5696397" name="Gap-filling DNA repair synthesis and ligation in GG-NER"/>
            <pathway-xref db="Reactome" id="R-HSA-9634638" name="Estrogen-dependent nuclear events downstream of ESR-membrane signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-5693568" name="Resolution of D-loop Structures through Holliday Junction Intermediates"/>
            <pathway-xref db="Reactome" id="R-HSA-3371453" name="Regulation of HSF1-mediated heat shock response"/>
            <pathway-xref db="Reactome" id="R-HSA-72706" name="GTP hydrolysis and joining of the 60S ribosomal subunit"/>
            <pathway-xref db="Reactome" id="R-HSA-174437" name="Removal of the Flap Intermediate from the C-strand"/>
            <pathway-xref db="MetaCyc" id="PWY-7172" name="flavonol acylglucoside biosynthesis III - quercetin derivatives"/>
            <pathway-xref db="MetaCyc" id="PWY-6314" name="plumbagin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-69166" name="Removal of the Flap Intermediate"/>
            <pathway-xref db="Reactome" id="R-MMU-3134973" name="LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production"/>
            <pathway-xref db="Reactome" id="R-GGA-2559585" name="Oncogene Induced Senescence"/>
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            <pathway-xref db="Reactome" id="R-SSC-9013973" name="TICAM1-dependent activation of IRF3/IRF7"/>
            <pathway-xref db="MetaCyc" id="PWY-6032" name="digitoxigenin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-9639288" name="Amino acids regulate mTORC1"/>
            <pathway-xref db="Reactome" id="R-SPO-3214847" name="HATs acetylate histones"/>
            <pathway-xref db="Reactome" id="R-DRE-8951664" name="Neddylation"/>
            <pathway-xref db="Reactome" id="R-SPO-73776" name="RNA Polymerase II Promoter Escape"/>
            <pathway-xref db="MetaCyc" id="PWY-7473" name="avenacin A-1 biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-5657655" name="MGMT-mediated DNA damage reversal"/>
            <pathway-xref db="MetaCyc" id="PWY-7739" name="aucuparin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-72706" name="GTP hydrolysis and joining of the 60S ribosomal subunit"/>
            <pathway-xref db="MetaCyc" id="PWY-7716" name="penicillin G and penicillin V biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-8939247" name="RUNX1 regulates transcription of genes involved in interleukin signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-6796648" name="TP53 Regulates Transcription of DNA Repair Genes"/>
            <pathway-xref db="Reactome" id="R-HSA-167172" name="Transcription of the HIV genome"/>
            <pathway-xref db="Reactome" id="R-DDI-1483248" name="Synthesis of PIPs at the ER membrane"/>
            <pathway-xref db="Reactome" id="R-SPO-75953" name="RNA Polymerase II Transcription Initiation"/>
            <pathway-xref db="MetaCyc" id="PWY-5059" name="pinobanksin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5024" name="L-arginine degradation XI"/>
            <pathway-xref db="Reactome" id="R-SPO-68867" name="Assembly of the pre-replicative complex"/>
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            <pathway-xref db="MetaCyc" id="PWY-7475" name="des-methyl avenacin A-1 biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6835" name="6-gingerol biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-DME-9617629" name="Regulation of FOXO transcriptional activity by acetylation"/>
            <pathway-xref db="Reactome" id="R-DME-8856828" name="Clathrin-mediated endocytosis"/>
            <pathway-xref db="MetaCyc" id="PWY-1121" name="suberin monomers biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8042" name="acylceramide biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-981" name="salicylate biosynthesis II"/>
            <pathway-xref db="Reactome" id="R-CEL-9607240" name="FLT3 Signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-9634638" name="Estrogen-dependent nuclear events downstream of ESR-membrane signaling"/>
            <pathway-xref db="Reactome" id="R-SCE-69166" name="Removal of the Flap Intermediate"/>
            <pathway-xref db="Reactome" id="R-RNO-209931" name="Serotonin and melatonin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-156711" name="Polo-like kinase mediated events"/>
            <pathway-xref db="Reactome" id="R-CEL-5693565" name="Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"/>
            <pathway-xref db="MetaCyc" id="PWY-7045" name="mithramycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DDI-917729" name="Endosomal Sorting Complex Required For Transport (ESCRT)"/>
            <pathway-xref db="MetaCyc" id="PWY-6917" name="vernolate biosynthesis III"/>
            <pathway-xref db="Reactome" id="R-RNO-2559584" name="Formation of Senescence-Associated Heterochromatin Foci (SAHF)"/>
            <pathway-xref db="MetaCyc" id="PWY-7230" name="ubiquinol-6 biosynthesis from 4-aminobenzoate (yeast)"/>
            <pathway-xref db="Reactome" id="R-BTA-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-HSA-9603798" name="Class I peroxisomal membrane protein import"/>
            <pathway-xref db="Reactome" id="R-RNO-114608" name="Platelet degranulation"/>
            <pathway-xref db="Reactome" id="R-DME-176187" name="Activation of ATR in response to replication stress"/>
            <pathway-xref db="Reactome" id="R-SCE-5687128" name="MAPK6/MAPK4 signaling"/>
            <pathway-xref db="Reactome" id="R-DME-72165" name="mRNA Splicing - Minor Pathway"/>
            <pathway-xref db="Reactome" id="R-MMU-9603798" name="Class I peroxisomal membrane protein import"/>
            <pathway-xref db="Reactome" id="R-RNO-68962" name="Activation of the pre-replicative complex"/>
            <pathway-xref db="MetaCyc" id="PWY-2723" name="trehalose degradation V"/>
            <pathway-xref db="Reactome" id="R-MMU-9013106" name="RHOC GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-3134963" name="DEx/H-box helicases activate type I IFN and inflammatory cytokines production"/>
            <pathway-xref db="Reactome" id="R-HSA-2644607" name="Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling"/>
            <pathway-xref db="Reactome" id="R-DME-73776" name="RNA Polymerase II Promoter Escape"/>
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            <pathway-xref db="Reactome" id="R-DDI-193648" name="NRAGE signals death through JNK"/>
            <pathway-xref db="Reactome" id="R-CEL-198693" name="AKT phosphorylates targets in the nucleus"/>
            <pathway-xref db="Reactome" id="R-HSA-6804116" name="TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest"/>
            <pathway-xref db="Reactome" id="R-DDI-975957" name="Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"/>
            <pathway-xref db="Reactome" id="R-RNO-110312" name="Translesion synthesis by REV1"/>
            <pathway-xref db="Reactome" id="R-HSA-8856828" name="Clathrin-mediated endocytosis"/>
            <pathway-xref db="MetaCyc" id="PWY-5473" name="hydroxycinnamic acid serotonin amides biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-179409" name="APC-Cdc20 mediated degradation of Nek2A"/>
            <pathway-xref db="MetaCyc" id="PWY-7079" name="geodin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-975956" name="Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"/>
            <pathway-xref db="Reactome" id="R-MMU-72086" name="mRNA Capping"/>
            <pathway-xref db="Reactome" id="R-HSA-3134975" name="Regulation of innate immune responses to cytosolic DNA"/>
            <pathway-xref db="Reactome" id="R-DME-350480" name="Activation of non-muscle Myosin II"/>
            <pathway-xref db="Reactome" id="R-RNO-5696394" name="DNA Damage Recognition in GG-NER"/>
            <pathway-xref db="Reactome" id="R-SPO-5693565" name="Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"/>
            <pathway-xref db="Reactome" id="R-MMU-9033241" name="Peroxisomal protein import"/>
            <pathway-xref db="Reactome" id="R-HSA-68911" name="G2 Phase"/>
            <pathway-xref db="Reactome" id="R-HSA-3270619" name="IRF3-mediated induction of type I IFN"/>
            <pathway-xref db="MetaCyc" id="PWY-7800" name="Ac/N-end rule pathway"/>
            <pathway-xref db="Reactome" id="R-MMU-4086400" name="PCP/CE pathway"/>
            <pathway-xref db="Reactome" id="R-MMU-3134975" name="Regulation of innate immune responses to cytosolic DNA"/>
            <pathway-xref db="Reactome" id="R-RNO-1912408" name="Pre-NOTCH Transcription and Translation"/>
            <pathway-xref db="MetaCyc" id="PWY-6378" name="putrebactin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-75953" name="RNA Polymerase II Transcription Initiation"/>
            <pathway-xref db="Reactome" id="R-DDI-9706019" name="RHOBTB3 ATPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-73779" name="RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"/>
            <pathway-xref db="Reactome" id="R-RNO-69473" name="G2/M DNA damage checkpoint"/>
            <pathway-xref db="Reactome" id="R-RNO-110314" name="Recognition of DNA damage by PCNA-containing replication complex"/>
            <pathway-xref db="Reactome" id="R-HSA-3134963" name="DEx/H-box helicases activate type I IFN and inflammatory cytokines production"/>
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            <pathway-xref db="MetaCyc" id="PWY-7738" name="polyacyltrehalose biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-DRE-111458" name="Formation of apoptosome"/>
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            <pathway-xref db="Reactome" id="R-MMU-8856828" name="Clathrin-mediated endocytosis"/>
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            <pathway-xref db="Reactome" id="R-MMU-3371511" name="HSF1 activation"/>
            <pathway-xref db="MetaCyc" id="PWY-6325" name="echinatin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-264870" name="Caspase-mediated cleavage of cytoskeletal proteins"/>
            <pathway-xref db="Reactome" id="R-DDI-176409" name="APC/C:Cdc20 mediated degradation of mitotic proteins"/>
            <pathway-xref db="MetaCyc" id="PWY-8058" name="2-deoxy-D-ribose degradation II"/>
            <pathway-xref db="Reactome" id="R-DRE-76066" name="RNA Polymerase III Transcription Initiation From Type 2 Promoter"/>
            <pathway-xref db="Reactome" id="R-MMU-5685938" name="HDR through Single Strand Annealing (SSA)"/>
            <pathway-xref db="MetaCyc" id="PWY-7577" name="ferrichrome biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DDI-4641258" name="Degradation of DVL"/>
            <pathway-xref db="MetaCyc" id="PWY-8085" name="picolinate degradation"/>
            <pathway-xref db="Reactome" id="R-DDI-6796648" name="TP53 Regulates Transcription of DNA Repair Genes"/>
            <pathway-xref db="MetaCyc" id="PWY-7940" name="lauryl-hydroxychlorobactene glucoside biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6039" name="chlorogenic acid biosynthesis I"/>
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            <pathway-xref db="Reactome" id="R-HSA-3371511" name="HSF1 activation"/>
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            <pathway-xref db="Reactome" id="R-DRE-6798695" name="Neutrophil degranulation"/>
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            <pathway-xref db="Reactome" id="R-MMU-5610785" name="GLI3 is processed to GLI3R by the proteasome"/>
            <pathway-xref db="Reactome" id="R-HSA-917729" name="Endosomal Sorting Complex Required For Transport (ESCRT)"/>
            <pathway-xref db="MetaCyc" id="PWY-2181" name="free phenylpropanoid acid biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-2644606" name="Constitutive Signaling by NOTCH1 PEST Domain Mutants"/>
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            <pathway-xref db="Reactome" id="R-DRE-9013422" name="RHOBTB1 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-5292" name="vindoline, vindorosine and vinblastine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SPO-5693548" name="Sensing of DNA Double Strand Breaks"/>
            <pathway-xref db="Reactome" id="R-MMU-3270619" name="IRF3-mediated induction of type I IFN"/>
            <pathway-xref db="Reactome" id="R-HSA-1169408" name="ISG15 antiviral mechanism"/>
            <pathway-xref db="MetaCyc" id="PWY-8039" name="mitomycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-674695" name="RNA Polymerase II Pre-transcription Events"/>
            <pathway-xref db="MetaCyc" id="PWY-7907" name="(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-422356" name="Regulation of insulin secretion"/>
            <pathway-xref db="Reactome" id="R-HSA-75815" name="Ubiquitin-dependent degradation of Cyclin D"/>
            <pathway-xref db="Reactome" id="R-SCE-6782135" name="Dual incision in TC-NER"/>
            <pathway-xref db="Reactome" id="R-DRE-6783310" name="Fanconi Anemia Pathway"/>
            <pathway-xref db="Reactome" id="R-HSA-6785807" name="Interleukin-4 and Interleukin-13 signaling"/>
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            <pathway-xref db="Reactome" id="R-HSA-9013106" name="RHOC GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-CEL-8856828" name="Clathrin-mediated endocytosis"/>
            <pathway-xref db="MetaCyc" id="PWY-7735" name="echinomycin and triostin A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DDI-917937" name="Iron uptake and transport"/>
            <pathway-xref db="MetaCyc" id="PWY-7154" name="ergosterol biosynthesis II"/>
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            <pathway-xref db="Reactome" id="R-BTA-936440" name="Negative regulators of DDX58/IFIH1 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-209931" name="Serotonin and melatonin biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-DDI-8951664" name="Neddylation"/>
            <pathway-xref db="Reactome" id="R-HSA-6782135" name="Dual incision in TC-NER"/>
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            <pathway-xref db="Reactome" id="R-RNO-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
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            <pathway-xref db="Reactome" id="R-DME-113418" name="Formation of the Early Elongation Complex"/>
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            <pathway-xref db="Reactome" id="R-RNO-9013422" name="RHOBTB1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-5693568" name="Resolution of D-loop Structures through Holliday Junction Intermediates"/>
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            <pathway-xref db="Reactome" id="R-RNO-4641262" name="Disassembly of the destruction complex and recruitment of AXIN to the membrane"/>
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            <pathway-xref db="MetaCyc" id="PWY-7861" name="N-hydroxy-L-pipecolate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SSC-3270619" name="IRF3-mediated induction of type I IFN"/>
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            <pathway-xref db="Reactome" id="R-MMU-8939236" name="RUNX1 regulates transcription of genes involved in differentiation of HSCs"/>
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            <pathway-xref db="MetaCyc" id="PWY-3385" name="choline biosynthesis I"/>
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            <pathway-xref db="Reactome" id="R-HSA-5607764" name="CLEC7A (Dectin-1) signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-418594" name="G alpha (i) signalling events"/>
            <pathway-xref db="MetaCyc" id="PWY-7564" name="bacimethrin and bacimethrin pyrophosphate biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-SCE-674695" name="RNA Polymerase II Pre-transcription Events"/>
            <pathway-xref db="Reactome" id="R-DME-6796648" name="TP53 Regulates Transcription of DNA Repair Genes"/>
            <pathway-xref db="Reactome" id="R-MMU-9013424" name="RHOV GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-CEL-72695" name="Formation of the ternary complex, and subsequently, the 43S complex"/>
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            <pathway-xref db="Reactome" id="R-MMU-5625886" name="Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3"/>
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            <pathway-xref db="Reactome" id="R-MMU-909733" name="Interferon alpha/beta signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-176409" name="APC/C:Cdc20 mediated degradation of mitotic proteins"/>
            <pathway-xref db="Reactome" id="R-SCE-5656121" name="Translesion synthesis by POLI"/>
            <pathway-xref db="Reactome" id="R-MMU-3214858" name="RMTs methylate histone arginines"/>
            <pathway-xref db="Reactome" id="R-DME-6803529" name="FGFR2 alternative splicing"/>
            <pathway-xref db="MetaCyc" id="PWY-6153" name="autoinducer AI-2 biosynthesis I"/>
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            <pathway-xref db="Reactome" id="R-HSA-111463" name="SMAC (DIABLO) binds to IAPs"/>
            <pathway-xref db="Reactome" id="R-CEL-9706019" name="RHOBTB3 ATPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-5687128" name="MAPK6/MAPK4 signaling"/>
            <pathway-xref db="Reactome" id="R-SPO-9018519" name="Estrogen-dependent gene expression"/>
            <pathway-xref db="Reactome" id="R-DME-350368" name="Activation of RHO1 by FZ:DSH complex"/>
            <pathway-xref db="Reactome" id="R-DME-3371568" name="Attenuation phase"/>
            <pathway-xref db="MetaCyc" id="PWY-6312" name="barbaloin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DDI-5674135" name="MAP2K and MAPK activation"/>
            <pathway-xref db="Reactome" id="R-MMU-176187" name="Activation of ATR in response to replication stress"/>
            <pathway-xref db="Reactome" id="R-MMU-9627069" name="Regulation of the apoptosome activity"/>
            <pathway-xref db="Reactome" id="R-HSA-8939902" name="Regulation of RUNX2 expression and activity"/>
            <pathway-xref db="MetaCyc" id="PWY-761" name="rhizobactin 1021 biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7673" name="fusarin C biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-392517" name="Rap1 signalling"/>
            <pathway-xref db="Reactome" id="R-HSA-1660517" name="Synthesis of PIPs at the late endosome membrane"/>
            <pathway-xref db="Reactome" id="R-MMU-5693548" name="Sensing of DNA Double Strand Breaks"/>
            <pathway-xref db="Reactome" id="R-RNO-4086400" name="PCP/CE pathway"/>
            <pathway-xref db="Reactome" id="R-DDI-6807505" name="RNA polymerase II transcribes snRNA genes"/>
            <pathway-xref db="Reactome" id="R-MMU-6804116" name="TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest"/>
            <pathway-xref db="Reactome" id="R-DDI-75815" name="Ubiquitin-dependent degradation of Cyclin D"/>
            <pathway-xref db="Reactome" id="R-SPO-174113" name="SCF-beta-TrCP mediated degradation of Emi1"/>
            <pathway-xref db="MetaCyc" id="PWY-7563" name="bassianin and desmethylbassianin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-3542" name="choline biosynthesis II"/>
            <pathway-xref db="Reactome" id="R-MMU-176407" name="Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase"/>
            <pathway-xref db="Reactome" id="R-RNO-264870" name="Caspase-mediated cleavage of cytoskeletal proteins"/>
            <pathway-xref db="MetaCyc" id="PWY-6672" name="cis-geranyl-CoA degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-5696394" name="DNA Damage Recognition in GG-NER"/>
            <pathway-xref db="Reactome" id="R-CEL-5632684" name="Hedgehog 'on' state"/>
            <pathway-xref db="Reactome" id="R-RNO-68689" name="CDC6 association with the ORC:origin complex"/>
            <pathway-xref db="Reactome" id="R-SPO-5358606" name="Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)"/>
            <pathway-xref db="MetaCyc" id="PWY-6722" name="candicidin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7161" name="polymethylated quercetin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-1799339" name="SRP-dependent cotranslational protein targeting to membrane"/>
            <pathway-xref db="Reactome" id="R-HSA-9018519" name="Estrogen-dependent gene expression"/>
            <pathway-xref db="Reactome" id="R-SCE-5668541" name="TNFR2 non-canonical NF-kB pathway"/>
            <pathway-xref db="Reactome" id="R-HSA-9029569" name="NR1H3 &amp; NR1H2 regulate gene expression linked to cholesterol transport and efflux"/>
            <pathway-xref db="MetaCyc" id="PWY-6689" name="tRNA splicing I"/>
            <pathway-xref db="Reactome" id="R-HSA-6804756" name="Regulation of TP53 Activity through Phosphorylation"/>
            <pathway-xref db="Reactome" id="R-SSC-168928" name="DDX58/IFIH1-mediated induction of interferon-alpha/beta"/>
            <pathway-xref db="Reactome" id="R-RNO-113418" name="Formation of the Early Elongation Complex"/>
            <pathway-xref db="MetaCyc" id="PWY-7292" name="oleate beta-oxidation (thioesterase-dependent, yeast)"/>
            <pathway-xref db="Reactome" id="R-RNO-76042" name="RNA Polymerase II Transcription Initiation And Promoter Clearance"/>
            <pathway-xref db="MetaCyc" id="PWY-6148" name="tetrahydromethanopterin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-917937" name="Iron uptake and transport"/>
            <pathway-xref db="Reactome" id="R-MMU-72695" name="Formation of the ternary complex, and subsequently, the 43S complex"/>
            <pathway-xref db="Reactome" id="R-SPO-917729" name="Endosomal Sorting Complex Required For Transport (ESCRT)"/>
            <pathway-xref db="MetaCyc" id="PWY-5105" name="hesperitin glycoside biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5875" name="staphyloxanthin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DDI-209931" name="Serotonin and melatonin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-8853884" name="Transcriptional Regulation by VENTX"/>
            <pathway-xref db="MetaCyc" id="PWY-4922" name="6-methoxymellein biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-8951664" name="Neddylation"/>
            <pathway-xref db="Reactome" id="R-CEL-9013406" name="RHOQ GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-7729" name="5,6-dimethylbenzimidazole biosynthesis II (anaerobic)"/>
            <pathway-xref db="MetaCyc" id="PWY-8157" name="avenanthramide biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6316" name="aromatic polyketides biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-9617828" name="FOXO-mediated transcription of cell cycle genes"/>
            <pathway-xref db="MetaCyc" id="PWY-5284" name="shisonin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-201681" name="TCF dependent signaling in response to WNT"/>
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            <pathway-xref db="MetaCyc" id="PWY-7050" name="icosapentaenoate biosynthesis IV (bacteria)"/>
            <pathway-xref db="Reactome" id="R-DDI-5689603" name="UCH proteinases"/>
            <pathway-xref db="MetaCyc" id="PWY-5870" name="ubiquinol-8 biosynthesis (late decarboxylation)"/>
            <pathway-xref db="Reactome" id="R-BTA-69231" name="Cyclin D associated events in G1"/>
            <pathway-xref db="MetaCyc" id="PWYG-321" name="mycolate biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-SPO-6782135" name="Dual incision in TC-NER"/>
            <pathway-xref db="MetaCyc" id="PWY-7485" name="tetracenomycin C biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-MMU-6814122" name="Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"/>
            <pathway-xref db="Reactome" id="R-CEL-9013405" name="RHOD GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-5607761" name="Dectin-1 mediated noncanonical NF-kB signaling"/>
            <pathway-xref db="Reactome" id="R-CEL-9035034" name="RHOF GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-76061" name="RNA Polymerase III Transcription Initiation From Type 1 Promoter"/>
            <pathway-xref db="Reactome" id="R-DRE-156827" name="L13a-mediated translational silencing of Ceruloplasmin expression"/>
            <pathway-xref db="Reactome" id="R-HSA-3371571" name="HSF1-dependent transactivation"/>
            <pathway-xref db="Reactome" id="R-MMU-68827" name="CDT1 association with the CDC6:ORC:origin complex"/>
            <pathway-xref db="Reactome" id="R-MMU-6782210" name="Gap-filling DNA repair synthesis and ligation in TC-NER"/>
            <pathway-xref db="Reactome" id="R-SCE-176187" name="Activation of ATR in response to replication stress"/>
            <pathway-xref db="MetaCyc" id="PWY-6922" name="L-Ndelta-acetylornithine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5846" name="colchicine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5313" name="superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)"/>
            <pathway-xref db="Reactome" id="R-CEL-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-MMU-450408" name="AUF1 (hnRNP D0) binds and destabilizes mRNA"/>
            <pathway-xref db="Reactome" id="R-MMU-76042" name="RNA Polymerase II Transcription Initiation And Promoter Clearance"/>
            <pathway-xref db="Reactome" id="R-HSA-354192" name="Integrin signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-5656121" name="Translesion synthesis by POLI"/>
            <pathway-xref db="MetaCyc" id="PWY-7104" name="dTDP-beta-L-megosamine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7708" name="lyngbyatoxin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-BTA-1606341" name="IRF3 mediated activation of type 1 IFN"/>
            <pathway-xref db="Reactome" id="R-SCE-3232118" name="SUMOylation of transcription factors"/>
            <pathway-xref db="Reactome" id="R-HSA-1236974" name="ER-Phagosome pathway"/>
            <pathway-xref db="Reactome" id="R-MMU-174430" name="Telomere C-strand synthesis initiation"/>
            <pathway-xref db="Reactome" id="R-BTA-674695" name="RNA Polymerase II Pre-transcription Events"/>
            <pathway-xref db="MetaCyc" id="PWY-7661" name="protein N-glycosylation (Haloferax volcanii)"/>
            <pathway-xref db="Reactome" id="R-MMU-111459" name="Activation of caspases through apoptosome-mediated cleavage"/>
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            <pathway-xref db="Reactome" id="R-DDI-176412" name="Phosphorylation of the APC/C"/>
            <pathway-xref db="Reactome" id="R-HSA-72702" name="Ribosomal scanning and start codon recognition"/>
            <pathway-xref db="Reactome" id="R-RNO-975957" name="Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"/>
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            <pathway-xref db="Reactome" id="R-DME-1181150" name="Signaling by NODAL"/>
            <pathway-xref db="MetaCyc" id="PWY-6427" name="rot-2'-enonate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7931" name="brominated pyrroles biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8117" name="colibactin biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-7029" name="terminal olefins biosynthesis II"/>
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            <pathway-xref db="Reactome" id="R-MMU-176412" name="Phosphorylation of the APC/C"/>
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            <pathway-xref db="Reactome" id="R-DDI-5673001" name="RAF/MAP kinase cascade"/>
            <pathway-xref db="Reactome" id="R-MMU-9035034" name="RHOF GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-GGA-1227882" name="TRAF mediated activation of IRF"/>
            <pathway-xref db="MetaCyc" id="PWY-6736" name="sulfur volatiles biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-198693" name="AKT phosphorylates targets in the nucleus"/>
            <pathway-xref db="Reactome" id="R-CEL-5696395" name="Formation of Incision Complex in GG-NER"/>
            <pathway-xref db="Reactome" id="R-DME-5693565" name="Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"/>
            <pathway-xref db="Reactome" id="R-HSA-9013973" name="TICAM1-dependent activation of IRF3/IRF7"/>
            <pathway-xref db="MetaCyc" id="PWY-7694" name="zwittermicin A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SCE-76042" name="RNA Polymerase II Transcription Initiation And Promoter Clearance"/>
            <pathway-xref db="Reactome" id="R-HSA-1606322" name="ZBP1(DAI) mediated induction of type I IFNs"/>
            <pathway-xref db="Reactome" id="R-DDI-72702" name="Ribosomal scanning and start codon recognition"/>
            <pathway-xref db="Reactome" id="R-MMU-9013406" name="RHOQ GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-7150" name="polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)"/>
            <pathway-xref db="Reactome" id="R-DRE-917729" name="Endosomal Sorting Complex Required For Transport (ESCRT)"/>
            <pathway-xref db="Reactome" id="R-RNO-76071" name="RNA Polymerase III Transcription Initiation From Type 3 Promoter"/>
            <pathway-xref db="Reactome" id="R-MMU-381676" name="Glucagon-like Peptide-1 (GLP1) regulates insulin secretion"/>
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            <pathway-xref db="MetaCyc" id="PWY-5139" name="pelargonidin conjugates biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-1538133" name="G0 and Early G1"/>
            <pathway-xref db="Reactome" id="R-HSA-8862803" name="Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models"/>
            <pathway-xref db="MetaCyc" id="PWY-7151" name="polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)"/>
            <pathway-xref db="Reactome" id="R-DME-77075" name="RNA Pol II CTD phosphorylation and interaction with CE"/>
            <pathway-xref db="Reactome" id="R-HSA-3371568" name="Attenuation phase"/>
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            <pathway-xref db="Reactome" id="R-DDI-75953" name="RNA Polymerase II Transcription Initiation"/>
            <pathway-xref db="MetaCyc" id="PWY-5477" name="gallotannin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-110320" name="Translesion Synthesis by POLH"/>
            <pathway-xref db="Reactome" id="R-SCE-6807505" name="RNA polymerase II transcribes snRNA genes"/>
            <pathway-xref db="Reactome" id="R-MMU-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-5687128" name="MAPK6/MAPK4 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-5632684" name="Hedgehog 'on' state"/>
            <pathway-xref db="Reactome" id="R-SPO-6807505" name="RNA polymerase II transcribes snRNA genes"/>
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            <pathway-xref db="Reactome" id="R-MMU-2514859" name="Inactivation, recovery and regulation of the phototransduction cascade"/>
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            <pathway-xref db="MetaCyc" id="PWY-7599" name="anditomin biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-RNO-5693548" name="Sensing of DNA Double Strand Breaks"/>
            <pathway-xref db="MetaCyc" id="PWY-6679" name="jadomycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-HSA-198693" name="AKT phosphorylates targets in the nucleus"/>
            <pathway-xref db="Reactome" id="R-MMU-9020702" name="Interleukin-1 signaling"/>
            <pathway-xref db="Reactome" id="R-CEL-9013420" name="RHOU GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-6783310" name="Fanconi Anemia Pathway"/>
            <pathway-xref db="Reactome" id="R-SPO-77075" name="RNA Pol II CTD phosphorylation and interaction with CE"/>
            <pathway-xref db="MetaCyc" id="PWY-5113" name="UDP-D-apiose biosynthesis (from UDP-D-glucuronate)"/>
            <pathway-xref db="Reactome" id="R-MMU-9614399" name="Regulation of localization of FOXO transcription factors"/>
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            <pathway-xref db="MetaCyc" id="PWY-7168" name="flavonol acylglucoside biosynthesis I - kaempferol derivatives"/>
            <pathway-xref db="Reactome" id="R-SPO-69166" name="Removal of the Flap Intermediate"/>
            <pathway-xref db="Reactome" id="R-XTR-4641258" name="Degradation of DVL"/>
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            <pathway-xref db="MetaCyc" id="PWY-7127" name="CDP-D-mannitol biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5959" name="aflatoxins B1 and G1 biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5307" name="gentiodelphin biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-HSA-167246" name="Tat-mediated elongation of the HIV-1 transcript"/>
            <pathway-xref db="MetaCyc" id="PWY-6409" name="pyoverdine I biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-CEL-6781823" name="Formation of TC-NER Pre-Incision Complex"/>
            <pathway-xref db="Reactome" id="R-MMU-9013026" name="RHOB GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DDI-69601" name="Ubiquitin Mediated Degradation of Phosphorylated Cdc25A"/>
            <pathway-xref db="Reactome" id="R-HSA-1169091" name="Activation of NF-kappaB in B cells"/>
            <pathway-xref db="MetaCyc" id="PWY-7160" name="polymethylated myricetin biosynthesis (tomato)"/>
            <pathway-xref db="MetaCyc" id="PWY-1186" name="L-homomethionine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-5689901" name="Metalloprotease DUBs"/>
            <pathway-xref db="MetaCyc" id="PWY-6971" name="oleandomycin biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-DDI-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-9705462" name="Inactivation of CSF3 (G-CSF) signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-76066" name="RNA Polymerase III Transcription Initiation From Type 2 Promoter"/>
            <pathway-xref db="Reactome" id="R-SPO-350562" name="Regulation of ornithine decarboxylase (ODC)"/>
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            <pathway-xref db="Reactome" id="R-MMU-3108214" name="SUMOylation of DNA damage response and repair proteins"/>
            <pathway-xref db="Reactome" id="R-HSA-9633012" name="Response of EIF2AK4 (GCN2) to amino acid deficiency"/>
            <pathway-xref db="Reactome" id="R-MMU-9696264" name="RND3 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-5665" name="vanillin biosynthesis I"/>
            <pathway-xref db="Reactome" id="R-MMU-9696270" name="RND2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-SPO-8866654" name="E3 ubiquitin ligases ubiquitinate target proteins"/>
            <pathway-xref db="Reactome" id="R-RNO-112382" name="Formation of RNA Pol II elongation complex"/>
            <pathway-xref db="Reactome" id="R-RNO-9617828" name="FOXO-mediated transcription of cell cycle genes"/>
            <pathway-xref db="Reactome" id="R-SPO-5358565" name="Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)"/>
            <pathway-xref db="Reactome" id="R-HSA-9696273" name="RND1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-CEL-68911" name="G2 Phase"/>
            <pathway-xref db="Reactome" id="R-DDI-176407" name="Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase"/>
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            <pathway-xref db="Reactome" id="R-HSA-2028269" name="Signaling by Hippo"/>
            <pathway-xref db="Reactome" id="R-HSA-167162" name="RNA Polymerase II HIV Promoter Escape"/>
            <pathway-xref db="MetaCyc" id="PWY-6456" name="serinol biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-211163" name="AKT-mediated inactivation of FOXO1A"/>
            <pathway-xref db="MetaCyc" id="PWY-5873" name="ubiquinol-7 biosynthesis (late decarboxylation)"/>
            <pathway-xref db="MetaCyc" id="PWY-7385" name="1,3-propanediol biosynthesis (engineered)"/>
            <pathway-xref db="Reactome" id="R-SSC-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-MMU-5684264" name="MAP3K8 (TPL2)-dependent MAPK1/3 activation"/>
            <pathway-xref db="Reactome" id="R-HSA-5678895" name="Defective CFTR causes cystic fibrosis"/>
            <pathway-xref db="MetaCyc" id="PWY-5048" name="rosmarinic acid biosynthesis I"/>
            <pathway-xref db="Reactome" id="R-HSA-6804758" name="Regulation of TP53 Activity through Acetylation"/>
            <pathway-xref db="Reactome" id="R-DME-975956" name="Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"/>
            <pathway-xref db="Reactome" id="R-HSA-111459" name="Activation of caspases through apoptosome-mediated cleavage"/>
            <pathway-xref db="MetaCyc" id="PWY-8055" name="palmitoyl ethanolamide biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-RNO-72086" name="mRNA Capping"/>
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        <model-ac>4bqaA00</model-ac>
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            <pathway-xref db="MetaCyc" id="PWY-6322" name="phosphinothricin tripeptide biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-RNO-264642" name="Acetylcholine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-1483166" name="Synthesis of PA"/>
            <pathway-xref db="Reactome" id="R-CFA-9013149" name="RAC1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-SCE-2559580" name="Oxidative Stress Induced Senescence"/>
            <pathway-xref db="Reactome" id="R-HSA-937041" name="IKK complex recruitment mediated by RIP1"/>
            <pathway-xref db="Reactome" id="R-MMU-8948751" name="Regulation of PTEN stability and activity"/>
            <pathway-xref db="Reactome" id="R-MMU-5578775" name="Ion homeostasis"/>
            <pathway-xref db="Reactome" id="R-MMU-9013026" name="RHOB GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-8948751" name="Regulation of PTEN stability and activity"/>
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            <pathway-xref db="Reactome" id="R-RNO-9696273" name="RND1 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-7342" name="superpathway of nicotine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-5578775" name="Ion homeostasis"/>
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            <pathway-xref db="MetaCyc" id="PWY-7564" name="bacimethrin and bacimethrin pyrophosphate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-1660661" name="Sphingolipid de novo biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-1660661" name="Sphingolipid de novo biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-MMU-2559580" name="Oxidative Stress Induced Senescence"/>
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            <pathway-xref db="Reactome" id="R-RNO-170984" name="ARMS-mediated activation"/>
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            <pathway-xref db="Reactome" id="R-MMU-201681" name="TCF dependent signaling in response to WNT"/>
            <pathway-xref db="Reactome" id="R-CFA-9013106" name="RHOC GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-3108214" name="SUMOylation of DNA damage response and repair proteins"/>
            <pathway-xref db="Reactome" id="R-HSA-9013026" name="RHOB GTPase cycle"/>
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            <pathway-xref db="Reactome" id="R-RNO-212676" name="Dopamine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-9696264" name="RND3 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-7025" name="gentamicin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-4551638" name="SUMOylation of chromatin organization proteins"/>
            <pathway-xref db="Reactome" id="R-DDI-9619229" name="Activation of RAC1 downstream of NMDARs"/>
            <pathway-xref db="Reactome" id="R-DME-8948751" name="Regulation of PTEN stability and activity"/>
            <pathway-xref db="Reactome" id="R-MMU-9696270" name="RND2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-937072" name="TRAF6-mediated induction of TAK1 complex within TLR4 complex"/>
            <pathway-xref db="Reactome" id="R-GGA-2559585" name="Oncogene Induced Senescence"/>
            <pathway-xref db="MetaCyc" id="PWY-5316" name="nicotine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-181429" name="Serotonin Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-912526" name="Interleukin receptor SHC signaling"/>
            <pathway-xref db="Reactome" id="R-DME-2559585" name="Oncogene Induced Senescence"/>
            <pathway-xref db="MetaCyc" id="PWY-5800" name="xylan biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-983695" name="Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"/>
            <pathway-xref db="Reactome" id="R-HSA-8943724" name="Regulation of PTEN gene transcription"/>
            <pathway-xref db="Reactome" id="R-HSA-9696273" name="RND1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-202433" name="Generation of second messenger molecules"/>
            <pathway-xref db="Reactome" id="R-HSA-9703465" name="Signaling by FLT3 fusion proteins"/>
            <pathway-xref db="Reactome" id="R-DME-3108214" name="SUMOylation of DNA damage response and repair proteins"/>
            <pathway-xref db="Reactome" id="R-GGA-3928663" name="EPHA-mediated growth cone collapse"/>
            <pathway-xref db="Reactome" id="R-MMU-8943724" name="Regulation of PTEN gene transcription"/>
            <pathway-xref db="Reactome" id="R-HSA-9013408" name="RHOG GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-264642" name="Acetylcholine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-9013404" name="RAC2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-181430" name="Norepinephrine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-8853659" name="RET signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-DME-114508" name="Effects of PIP2 hydrolysis"/>
            <pathway-xref db="Reactome" id="R-MMU-936964" name="Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon"/>
            <pathway-xref db="Reactome" id="R-MMU-2151201" name="Transcriptional activation of mitochondrial biogenesis"/>
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            <pathway-xref db="Reactome" id="R-MMU-9031628" name="NGF-stimulated transcription"/>
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            <pathway-xref db="Reactome" id="R-MMU-5675221" name="Negative regulation of MAPK pathway"/>
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            <pathway-xref db="Reactome" id="R-CEL-212676" name="Dopamine Neurotransmitter Release Cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-6190" name="2,4-dichlorotoluene degradation"/>
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            <pathway-xref db="Reactome" id="R-MMU-114604" name="GPVI-mediated activation cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-3108214" name="SUMOylation of DNA damage response and repair proteins"/>
            <pathway-xref db="Reactome" id="R-MMU-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-5545619" name="XAV939 stabilizes AXIN"/>
            <pathway-xref db="MetaCyc" id="PWY-6804" name="diacylglycerol biosynthesis (PUFA enrichment in oilseed)"/>
            <pathway-xref db="Reactome" id="R-HSA-9673768" name="Signaling by membrane-tethered fusions of PDGFRA or PDGFRB"/>
            <pathway-xref db="Reactome" id="R-MMU-2424491" name="DAP12 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-7450" name="anthocyanidin modification (Arabidopsis)"/>
            <pathway-xref db="Reactome" id="R-HSA-2424491" name="DAP12 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-8853659" name="RET signaling"/>
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            <pathway-xref db="Reactome" id="R-CEL-5674135" name="MAP2K and MAPK activation"/>
            <pathway-xref db="MetaCyc" id="PWY-8248" name="lipid A-core biosynthesis (P. gingivalis)"/>
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            <pathway-xref db="Reactome" id="R-RNO-1660499" name="Synthesis of PIPs at the plasma membrane"/>
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            <pathway-xref db="Reactome" id="R-RNO-2682334" name="EPH-Ephrin signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-2682334" name="EPH-Ephrin signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-6368" name="3-phosphoinositide degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-9013106" name="RHOC GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-CEL-2559580" name="Oxidative Stress Induced Senescence"/>
            <pathway-xref db="Reactome" id="R-HSA-181429" name="Serotonin Neurotransmitter Release Cycle"/>
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            <pathway-xref db="Reactome" id="R-RNO-9013026" name="RHOB GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-9013148" name="CDC42 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-6148" name="tetrahydromethanopterin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-6804760" name="Regulation of TP53 Activity through Methylation"/>
            <pathway-xref db="Reactome" id="R-HSA-9013148" name="CDC42 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-5578775" name="Ion homeostasis"/>
            <pathway-xref db="MetaCyc" id="PWY-6558" name="heparan sulfate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-1912408" name="Pre-NOTCH Transcription and Translation"/>
            <pathway-xref db="Reactome" id="R-DRE-6809371" name="Formation of the cornified envelope"/>
            <pathway-xref db="Reactome" id="R-HSA-166166" name="MyD88-independent TLR4 cascade"/>
            <pathway-xref db="Reactome" id="R-MMU-8849469" name="PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1"/>
            <pathway-xref db="Reactome" id="R-DME-4570464" name="SUMOylation of RNA binding proteins"/>
            <pathway-xref db="Reactome" id="R-MMU-1660499" name="Synthesis of PIPs at the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-HSA-9656223" name="Signaling by RAF1 mutants"/>
            <pathway-xref db="MetaCyc" id="PWY-1921" name="indole-3-acetate activation II"/>
            <pathway-xref db="Reactome" id="R-HSA-5620971" name="Pyroptosis"/>
            <pathway-xref db="MetaCyc" id="PWY-7277" name="sphingolipid biosynthesis (mammals)"/>
            <pathway-xref db="Reactome" id="R-DDI-111932" name="CaMK IV-mediated phosphorylation of CREB"/>
            <pathway-xref db="Reactome" id="R-MMU-204005" name="COPII-mediated vesicle transport"/>
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            <pathway-xref db="Reactome" id="R-RNO-1855204" name="Synthesis of IP3 and IP4 in the cytosol"/>
            <pathway-xref db="Reactome" id="R-HSA-3928665" name="EPH-ephrin mediated repulsion of cells"/>
            <pathway-xref db="Reactome" id="R-HSA-201681" name="TCF dependent signaling in response to WNT"/>
            <pathway-xref db="MetaCyc" id="PWY-6848" name="rutin degradation"/>
            <pathway-xref db="Reactome" id="R-DRE-3928662" name="EPHB-mediated forward signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-7769" name="phosalacine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-1912408" name="Pre-NOTCH Transcription and Translation"/>
            <pathway-xref db="Reactome" id="R-HSA-1912408" name="Pre-NOTCH Transcription and Translation"/>
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            <pathway-xref db="Reactome" id="R-MMU-8853659" name="RET signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-3928664" name="Ephrin signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-9013148" name="CDC42 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DME-1660661" name="Sphingolipid de novo biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7713" name="nivalenol biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DDI-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-HSA-9696270" name="RND2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-CEL-6794361" name="Neurexins and neuroligins"/>
            <pathway-xref db="Reactome" id="R-DRE-8956319" name="Nucleobase catabolism"/>
            <pathway-xref db="Reactome" id="R-HSA-9696264" name="RND3 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-CFA-9013026" name="RHOB GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-9696273" name="RND1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-6802955" name="Paradoxical activation of RAF signaling by kinase inactive BRAF"/>
            <pathway-xref db="Reactome" id="R-HSA-373760" name="L1CAM interactions"/>
            <pathway-xref db="Reactome" id="R-DRE-3928665" name="EPH-ephrin mediated repulsion of cells"/>
            <pathway-xref db="Reactome" id="R-HSA-9662360" name="Sensory processing of sound by inner hair cells of the cochlea"/>
            <pathway-xref db="Reactome" id="R-MMU-1855204" name="Synthesis of IP3 and IP4 in the cytosol"/>
            <pathway-xref db="Reactome" id="R-MMU-202433" name="Generation of second messenger molecules"/>
            <pathway-xref db="Reactome" id="R-HSA-388844" name="Receptor-type tyrosine-protein phosphatases"/>
            <pathway-xref db="Reactome" id="R-MMU-2559585" name="Oncogene Induced Senescence"/>
            <pathway-xref db="Reactome" id="R-MMU-3928663" name="EPHA-mediated growth cone collapse"/>
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            <pathway-xref db="Reactome" id="R-CFA-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-8058" name="2-deoxy-D-ribose degradation II"/>
            <pathway-xref db="Reactome" id="R-HSA-4570464" name="SUMOylation of RNA binding proteins"/>
            <pathway-xref db="MetaCyc" id="PWY-7730" name="T-2 toxin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-5628897" name="TP53 Regulates Metabolic Genes"/>
            <pathway-xref db="Reactome" id="R-DME-209190" name="Phosphorylation of CI"/>
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            <pathway-xref db="Reactome" id="R-HSA-204005" name="COPII-mediated vesicle transport"/>
            <pathway-xref db="Reactome" id="R-DRE-1660499" name="Synthesis of PIPs at the plasma membrane"/>
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            <pathway-xref db="Reactome" id="R-DME-209214" name="Phosphorylation of SMO"/>
            <pathway-xref db="Reactome" id="R-MMU-181429" name="Serotonin Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-9013149" name="RAC1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-8956319" name="Nucleobase catabolism"/>
            <pathway-xref db="Reactome" id="R-HSA-8939236" name="RUNX1 regulates transcription of genes involved in differentiation of HSCs"/>
            <pathway-xref db="MetaCyc" id="PWY-6720" name="toyocamycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DDI-5675482" name="Regulation of necroptotic cell death"/>
            <pathway-xref db="Reactome" id="R-HSA-9013423" name="RAC3 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-3928665" name="EPH-ephrin mediated repulsion of cells"/>
            <pathway-xref db="Reactome" id="R-HSA-170984" name="ARMS-mediated activation"/>
            <pathway-xref db="Reactome" id="R-SPO-2559580" name="Oxidative Stress Induced Senescence"/>
            <pathway-xref db="Reactome" id="R-DRE-2682334" name="EPH-Ephrin signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-8953750" name="Transcriptional Regulation by E2F6"/>
            <pathway-xref db="Reactome" id="R-HSA-9013420" name="RHOU GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-7511" name="protein ubiquitination"/>
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            <pathway-xref db="Reactome" id="R-MMU-264642" name="Acetylcholine Neurotransmitter Release Cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-7815" name="poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)"/>
            <pathway-xref db="Reactome" id="R-HSA-212676" name="Dopamine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-3928662" name="EPHB-mediated forward signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-3928663" name="EPHA-mediated growth cone collapse"/>
            <pathway-xref db="Reactome" id="R-CEL-983695" name="Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"/>
            <pathway-xref db="Reactome" id="R-HSA-8849469" name="PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1"/>
            <pathway-xref db="Reactome" id="R-HSA-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-6803205" name="TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain"/>
            <pathway-xref db="Reactome" id="R-HSA-168164" name="Toll Like Receptor 3 (TLR3) Cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-210500" name="Glutamate Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-166166" name="MyD88-independent TLR4 cascade"/>
            <pathway-xref db="MetaCyc" id="PWY-8247" name="(Kdo)2-lipid A biosynthesis (P. gingivalis)"/>
            <pathway-xref db="Reactome" id="R-DRE-3928664" name="Ephrin signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-2871809" name="FCERI mediated Ca+2 mobilization"/>
            <pathway-xref db="Reactome" id="R-MMU-2871809" name="FCERI mediated Ca+2 mobilization"/>
            <pathway-xref db="Reactome" id="R-RNO-9013406" name="RHOQ GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-9013423" name="RAC3 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-6803204" name="TP53 Regulates Transcription of Genes Involved in Cytochrome C Release"/>
            <pathway-xref db="Reactome" id="R-DRE-1855204" name="Synthesis of IP3 and IP4 in the cytosol"/>
            <pathway-xref db="Reactome" id="R-HSA-6804759" name="Regulation of TP53 Activity through Association with Co-factors"/>
            <pathway-xref db="Reactome" id="R-MMU-3928664" name="Ephrin signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-7981" name="alpha-dystroglycan glycosylation"/>
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            <pathway-xref db="Reactome" id="R-DME-8939243" name="RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"/>
            <pathway-xref db="Reactome" id="R-RNO-9013106" name="RHOC GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-937072" name="TRAF6-mediated induction of TAK1 complex within TLR4 complex"/>
            <pathway-xref db="MetaCyc" id="PWY-8106" name="queuosine biosynthesis III (queuosine salvage)"/>
            <pathway-xref db="Reactome" id="R-MMU-8953750" name="Transcriptional Regulation by E2F6"/>
            <pathway-xref db="Reactome" id="R-MMU-9013149" name="RAC1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-9013420" name="RHOU GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-8956319" name="Nucleobase catabolism"/>
            <pathway-xref db="MetaCyc" id="PWY-7367" name="phosphatidylcholine resynthesis via glycerophosphocholine"/>
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            <pathway-xref db="Reactome" id="R-HSA-3928662" name="EPHB-mediated forward signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-936964" name="Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon"/>
            <pathway-xref db="MetaCyc" id="PWY-5381" name="NAD salvage (plants)"/>
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        </signature>
        <model-ac>PS00346</model-ac>
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            <location-fragments>
              <patternscan-location-fragment start="369" end="384" dc-status="CONTINUOUS"/>
            </location-fragments>
            <alignment>KpkMnYEkLSRGLRyY</alignment>
          </patternscan-location>
        </locations>
      </patternscan-match>
      <profilescan-match>
        <signature ac="PS51433" desc="Pointed (PNT) domain profile." name="PNT">
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            </location-fragments>
            <alignment>LTYSSWSERAENEEIPPNPRDWTPRHVSLWLDWTMREFSLESDTFKDFLksfqLSGSEMCALSKESFMDQAPRCVGDILYEHLQLLLQQD</alignment>
          </profilescan-location>
        </locations>
      </profilescan-match>
      <profilescan-match>
        <signature ac="PS50061" desc="Ets-domain profile." name="ETS_DOMAIN_3">
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            <pathway-xref db="MetaCyc" id="PWY-7025" name="gentamicin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-4551638" name="SUMOylation of chromatin organization proteins"/>
            <pathway-xref db="Reactome" id="R-DDI-9619229" name="Activation of RAC1 downstream of NMDARs"/>
            <pathway-xref db="Reactome" id="R-DME-8948751" name="Regulation of PTEN stability and activity"/>
            <pathway-xref db="Reactome" id="R-MMU-9696270" name="RND2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-937072" name="TRAF6-mediated induction of TAK1 complex within TLR4 complex"/>
            <pathway-xref db="Reactome" id="R-GGA-2559585" name="Oncogene Induced Senescence"/>
            <pathway-xref db="MetaCyc" id="PWY-5316" name="nicotine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-181429" name="Serotonin Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-912526" name="Interleukin receptor SHC signaling"/>
            <pathway-xref db="Reactome" id="R-DME-2559585" name="Oncogene Induced Senescence"/>
            <pathway-xref db="MetaCyc" id="PWY-5800" name="xylan biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-983695" name="Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"/>
            <pathway-xref db="Reactome" id="R-HSA-8943724" name="Regulation of PTEN gene transcription"/>
            <pathway-xref db="Reactome" id="R-HSA-9696273" name="RND1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-202433" name="Generation of second messenger molecules"/>
            <pathway-xref db="Reactome" id="R-HSA-9703465" name="Signaling by FLT3 fusion proteins"/>
            <pathway-xref db="Reactome" id="R-DME-3108214" name="SUMOylation of DNA damage response and repair proteins"/>
            <pathway-xref db="Reactome" id="R-GGA-3928663" name="EPHA-mediated growth cone collapse"/>
            <pathway-xref db="Reactome" id="R-MMU-8943724" name="Regulation of PTEN gene transcription"/>
            <pathway-xref db="Reactome" id="R-HSA-9013408" name="RHOG GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-264642" name="Acetylcholine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-9013404" name="RAC2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-181430" name="Norepinephrine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-8853659" name="RET signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-DME-114508" name="Effects of PIP2 hydrolysis"/>
            <pathway-xref db="Reactome" id="R-MMU-936964" name="Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon"/>
            <pathway-xref db="Reactome" id="R-MMU-2151201" name="Transcriptional activation of mitochondrial biogenesis"/>
            <pathway-xref db="Reactome" id="R-CEL-388844" name="Receptor-type tyrosine-protein phosphatases"/>
            <pathway-xref db="Reactome" id="R-MMU-9031628" name="NGF-stimulated transcription"/>
            <pathway-xref db="Reactome" id="R-HSA-3899300" name="SUMOylation of transcription cofactors"/>
            <pathway-xref db="Reactome" id="R-MMU-5675221" name="Negative regulation of MAPK pathway"/>
            <pathway-xref db="Reactome" id="R-RNO-388844" name="Receptor-type tyrosine-protein phosphatases"/>
            <pathway-xref db="Reactome" id="R-MMU-1660661" name="Sphingolipid de novo biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-4551638" name="SUMOylation of chromatin organization proteins"/>
            <pathway-xref db="Reactome" id="R-HSA-5601884" name="PIWI-interacting RNA (piRNA) biogenesis"/>
            <pathway-xref db="Reactome" id="R-MMU-4641257" name="Degradation of AXIN"/>
            <pathway-xref db="Reactome" id="R-CEL-212676" name="Dopamine Neurotransmitter Release Cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-6190" name="2,4-dichlorotoluene degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-9013424" name="RHOV GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-114604" name="GPVI-mediated activation cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-3108214" name="SUMOylation of DNA damage response and repair proteins"/>
            <pathway-xref db="Reactome" id="R-MMU-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-5545619" name="XAV939 stabilizes AXIN"/>
            <pathway-xref db="MetaCyc" id="PWY-6804" name="diacylglycerol biosynthesis (PUFA enrichment in oilseed)"/>
            <pathway-xref db="Reactome" id="R-HSA-9673768" name="Signaling by membrane-tethered fusions of PDGFRA or PDGFRB"/>
            <pathway-xref db="Reactome" id="R-MMU-2424491" name="DAP12 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-7450" name="anthocyanidin modification (Arabidopsis)"/>
            <pathway-xref db="Reactome" id="R-HSA-2424491" name="DAP12 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-8853659" name="RET signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-7039" name="phosphatidate metabolism, as a signaling molecule"/>
            <pathway-xref db="Reactome" id="R-CEL-5674135" name="MAP2K and MAPK activation"/>
            <pathway-xref db="MetaCyc" id="PWY-8248" name="lipid A-core biosynthesis (P. gingivalis)"/>
            <pathway-xref db="Reactome" id="R-DME-201681" name="TCF dependent signaling in response to WNT"/>
            <pathway-xref db="Reactome" id="R-RNO-1660499" name="Synthesis of PIPs at the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-RNO-3928665" name="EPH-ephrin mediated repulsion of cells"/>
            <pathway-xref db="Reactome" id="R-RNO-2682334" name="EPH-Ephrin signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-2682334" name="EPH-Ephrin signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-6368" name="3-phosphoinositide degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-9013106" name="RHOC GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-CEL-2559580" name="Oxidative Stress Induced Senescence"/>
            <pathway-xref db="Reactome" id="R-HSA-181429" name="Serotonin Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-9031628" name="NGF-stimulated transcription"/>
            <pathway-xref db="Reactome" id="R-RNO-983695" name="Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"/>
            <pathway-xref db="Reactome" id="R-RNO-9013026" name="RHOB GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-9013148" name="CDC42 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-6148" name="tetrahydromethanopterin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-6804760" name="Regulation of TP53 Activity through Methylation"/>
            <pathway-xref db="Reactome" id="R-HSA-9013148" name="CDC42 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-5578775" name="Ion homeostasis"/>
            <pathway-xref db="MetaCyc" id="PWY-6558" name="heparan sulfate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-1912408" name="Pre-NOTCH Transcription and Translation"/>
            <pathway-xref db="Reactome" id="R-DRE-6809371" name="Formation of the cornified envelope"/>
            <pathway-xref db="Reactome" id="R-HSA-166166" name="MyD88-independent TLR4 cascade"/>
            <pathway-xref db="Reactome" id="R-MMU-8849469" name="PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1"/>
            <pathway-xref db="Reactome" id="R-DME-4570464" name="SUMOylation of RNA binding proteins"/>
            <pathway-xref db="Reactome" id="R-MMU-1660499" name="Synthesis of PIPs at the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-HSA-9656223" name="Signaling by RAF1 mutants"/>
            <pathway-xref db="MetaCyc" id="PWY-1921" name="indole-3-acetate activation II"/>
            <pathway-xref db="Reactome" id="R-HSA-5620971" name="Pyroptosis"/>
            <pathway-xref db="MetaCyc" id="PWY-7277" name="sphingolipid biosynthesis (mammals)"/>
            <pathway-xref db="Reactome" id="R-DDI-111932" name="CaMK IV-mediated phosphorylation of CREB"/>
            <pathway-xref db="Reactome" id="R-MMU-204005" name="COPII-mediated vesicle transport"/>
            <pathway-xref db="Reactome" id="R-DME-8953750" name="Transcriptional Regulation by E2F6"/>
            <pathway-xref db="Reactome" id="R-HSA-1660499" name="Synthesis of PIPs at the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-RNO-1855204" name="Synthesis of IP3 and IP4 in the cytosol"/>
            <pathway-xref db="Reactome" id="R-HSA-3928665" name="EPH-ephrin mediated repulsion of cells"/>
            <pathway-xref db="Reactome" id="R-HSA-201681" name="TCF dependent signaling in response to WNT"/>
            <pathway-xref db="MetaCyc" id="PWY-6848" name="rutin degradation"/>
            <pathway-xref db="Reactome" id="R-DRE-3928662" name="EPHB-mediated forward signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-7769" name="phosalacine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-1912408" name="Pre-NOTCH Transcription and Translation"/>
            <pathway-xref db="Reactome" id="R-HSA-1912408" name="Pre-NOTCH Transcription and Translation"/>
            <pathway-xref db="Reactome" id="R-HSA-6802952" name="Signaling by BRAF and RAF fusions"/>
            <pathway-xref db="MetaCyc" id="PWY-7404" name="ceramide phosphoethanolamine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-8853659" name="RET signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-3928664" name="Ephrin signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-9013148" name="CDC42 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DME-1660661" name="Sphingolipid de novo biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7713" name="nivalenol biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DDI-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-HSA-9696270" name="RND2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-CEL-6794361" name="Neurexins and neuroligins"/>
            <pathway-xref db="Reactome" id="R-DRE-8956319" name="Nucleobase catabolism"/>
            <pathway-xref db="Reactome" id="R-HSA-9696264" name="RND3 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-CFA-9013026" name="RHOB GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-9696273" name="RND1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-6802955" name="Paradoxical activation of RAF signaling by kinase inactive BRAF"/>
            <pathway-xref db="Reactome" id="R-HSA-373760" name="L1CAM interactions"/>
            <pathway-xref db="Reactome" id="R-DRE-3928665" name="EPH-ephrin mediated repulsion of cells"/>
            <pathway-xref db="Reactome" id="R-HSA-9662360" name="Sensory processing of sound by inner hair cells of the cochlea"/>
            <pathway-xref db="Reactome" id="R-MMU-1855204" name="Synthesis of IP3 and IP4 in the cytosol"/>
            <pathway-xref db="Reactome" id="R-MMU-202433" name="Generation of second messenger molecules"/>
            <pathway-xref db="Reactome" id="R-HSA-388844" name="Receptor-type tyrosine-protein phosphatases"/>
            <pathway-xref db="Reactome" id="R-MMU-2559585" name="Oncogene Induced Senescence"/>
            <pathway-xref db="Reactome" id="R-MMU-3928663" name="EPHA-mediated growth cone collapse"/>
            <pathway-xref db="Reactome" id="R-MMU-4570464" name="SUMOylation of RNA binding proteins"/>
            <pathway-xref db="Reactome" id="R-CFA-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-8058" name="2-deoxy-D-ribose degradation II"/>
            <pathway-xref db="Reactome" id="R-HSA-4570464" name="SUMOylation of RNA binding proteins"/>
            <pathway-xref db="MetaCyc" id="PWY-7730" name="T-2 toxin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-5628897" name="TP53 Regulates Metabolic Genes"/>
            <pathway-xref db="Reactome" id="R-DME-209190" name="Phosphorylation of CI"/>
            <pathway-xref db="Reactome" id="R-RNO-3928662" name="EPHB-mediated forward signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-204005" name="COPII-mediated vesicle transport"/>
            <pathway-xref db="Reactome" id="R-DRE-1660499" name="Synthesis of PIPs at the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-HSA-3928664" name="Ephrin signaling"/>
            <pathway-xref db="Reactome" id="R-DME-209214" name="Phosphorylation of SMO"/>
            <pathway-xref db="Reactome" id="R-MMU-181429" name="Serotonin Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-9013149" name="RAC1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-8956319" name="Nucleobase catabolism"/>
            <pathway-xref db="Reactome" id="R-HSA-8939236" name="RUNX1 regulates transcription of genes involved in differentiation of HSCs"/>
            <pathway-xref db="MetaCyc" id="PWY-6720" name="toyocamycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DDI-5675482" name="Regulation of necroptotic cell death"/>
            <pathway-xref db="Reactome" id="R-HSA-9013423" name="RAC3 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-3928665" name="EPH-ephrin mediated repulsion of cells"/>
            <pathway-xref db="Reactome" id="R-HSA-170984" name="ARMS-mediated activation"/>
            <pathway-xref db="Reactome" id="R-SPO-2559580" name="Oxidative Stress Induced Senescence"/>
            <pathway-xref db="Reactome" id="R-DRE-2682334" name="EPH-Ephrin signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-8953750" name="Transcriptional Regulation by E2F6"/>
            <pathway-xref db="Reactome" id="R-HSA-9013420" name="RHOU GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-7511" name="protein ubiquitination"/>
            <pathway-xref db="Reactome" id="R-HSA-6803211" name="TP53 Regulates Transcription of Death Receptors and Ligands"/>
            <pathway-xref db="Reactome" id="R-MMU-264642" name="Acetylcholine Neurotransmitter Release Cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-7815" name="poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)"/>
            <pathway-xref db="Reactome" id="R-HSA-212676" name="Dopamine Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-3928662" name="EPHB-mediated forward signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-3928663" name="EPHA-mediated growth cone collapse"/>
            <pathway-xref db="Reactome" id="R-CEL-983695" name="Antigen activates B Cell Receptor (BCR) leading to generation of second messengers"/>
            <pathway-xref db="Reactome" id="R-HSA-8849469" name="PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1"/>
            <pathway-xref db="Reactome" id="R-HSA-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-6803205" name="TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain"/>
            <pathway-xref db="Reactome" id="R-HSA-168164" name="Toll Like Receptor 3 (TLR3) Cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-210500" name="Glutamate Neurotransmitter Release Cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-166166" name="MyD88-independent TLR4 cascade"/>
            <pathway-xref db="MetaCyc" id="PWY-8247" name="(Kdo)2-lipid A biosynthesis (P. gingivalis)"/>
            <pathway-xref db="Reactome" id="R-DRE-3928664" name="Ephrin signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-2871809" name="FCERI mediated Ca+2 mobilization"/>
            <pathway-xref db="Reactome" id="R-MMU-2871809" name="FCERI mediated Ca+2 mobilization"/>
            <pathway-xref db="Reactome" id="R-RNO-9013406" name="RHOQ GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-9013423" name="RAC3 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-6803204" name="TP53 Regulates Transcription of Genes Involved in Cytochrome C Release"/>
            <pathway-xref db="Reactome" id="R-DRE-1855204" name="Synthesis of IP3 and IP4 in the cytosol"/>
            <pathway-xref db="Reactome" id="R-HSA-6804759" name="Regulation of TP53 Activity through Association with Co-factors"/>
            <pathway-xref db="Reactome" id="R-MMU-3928664" name="Ephrin signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-7981" name="alpha-dystroglycan glycosylation"/>
            <pathway-xref db="MetaCyc" id="PWY-7712" name="deoxynivalenol biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-8939243" name="RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"/>
            <pathway-xref db="Reactome" id="R-RNO-9013106" name="RHOC GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-937072" name="TRAF6-mediated induction of TAK1 complex within TLR4 complex"/>
            <pathway-xref db="MetaCyc" id="PWY-8106" name="queuosine biosynthesis III (queuosine salvage)"/>
            <pathway-xref db="Reactome" id="R-MMU-8953750" name="Transcriptional Regulation by E2F6"/>
            <pathway-xref db="Reactome" id="R-MMU-9013149" name="RAC1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-9013420" name="RHOU GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-8956319" name="Nucleobase catabolism"/>
            <pathway-xref db="MetaCyc" id="PWY-7367" name="phosphatidylcholine resynthesis via glycerophosphocholine"/>
            <pathway-xref db="MetaCyc" id="PWY-7660" name="tryptoquialanine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-3928662" name="EPHB-mediated forward signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-936964" name="Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon"/>
            <pathway-xref db="MetaCyc" id="PWY-5381" name="NAD salvage (plants)"/>
            <pathway-xref db="Reactome" id="R-MMU-2682334" name="EPH-Ephrin signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-7467" name="2-acetamido-4-amino-2,4,6-trideoxy-alpha-D-galactosyl-diphospho-ditrans,octacis-undecaprenol biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-6794361" name="Neurexins and neuroligins"/>
            <pathway-xref db="Reactome" id="R-HSA-9013106" name="RHOC GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-CFA-9013148" name="CDC42 GTPase cycle"/>
          </entry>
          <signature-library-release library="SUPERFAMILY" version="1.75"/>
        </signature>
        <model-ac>0045998</model-ac>
        <locations>
          <superfamilyhmmer3-location hmm-length="110" start="64" end="170">
            <location-fragments>
              <superfamilyhmmer3-location-fragment start="64" end="170" dc-status="CONTINUOUS"/>
            </location-fragments>
          </superfamilyhmmer3-location>
        </locations>
      </superfamilyhmmer3-match>
      <superfamilyhmmer3-match evalue="3.54E-46">
        <signature ac="SSF46785" name="&quot;Winged helix&quot; DNA-binding domain">
          <entry ac="IPR036390" desc="Winged helix DNA-binding domain superfamily" name="WH_DNA-bd_sf" type="HOMOLOGOUS_SUPERFAMILY">
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            <pathway-xref db="Reactome" id="R-CEL-6804116" name="TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest"/>
            <pathway-xref db="Reactome" id="R-DME-674695" name="RNA Polymerase II Pre-transcription Events"/>
            <pathway-xref db="Reactome" id="R-CEL-69601" name="Ubiquitin Mediated Degradation of Phosphorylated Cdc25A"/>
            <pathway-xref db="Reactome" id="R-HSA-113418" name="Formation of the Early Elongation Complex"/>
            <pathway-xref db="MetaCyc" id="PWY-7325" name="salvigenin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-2565942" name="Regulation of PLK1 Activity at G2/M Transition"/>
            <pathway-xref db="Reactome" id="R-DME-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-MMU-72203" name="Processing of Capped Intron-Containing Pre-mRNA"/>
            <pathway-xref db="Reactome" id="R-BTA-936964" name="Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon"/>
            <pathway-xref db="Reactome" id="R-DME-211163" name="AKT-mediated inactivation of FOXO1A"/>
            <pathway-xref db="Reactome" id="R-HSA-6791226" name="Major pathway of rRNA processing in the nucleolus and cytosol"/>
            <pathway-xref db="Reactome" id="R-MMU-2565942" name="Regulation of PLK1 Activity at G2/M Transition"/>
            <pathway-xref db="MetaCyc" id="PWY-7629" name="yatein biosynthesis II"/>
            <pathway-xref db="MetaCyc" id="PWY-6973" name="dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7049" name="icosapentaenoate biosynthesis II (6-desaturase, mammals)"/>
            <pathway-xref db="Reactome" id="R-MMU-6791226" name="Major pathway of rRNA processing in the nucleolus and cytosol"/>
            <pathway-xref db="Reactome" id="R-SCE-110312" name="Translesion synthesis by REV1"/>
            <pathway-xref db="Reactome" id="R-MMU-75102" name="C6 deamination of adenosine"/>
            <pathway-xref db="Reactome" id="R-HSA-5693616" name="Presynaptic phase of homologous DNA pairing and strand exchange"/>
            <pathway-xref db="Reactome" id="R-CEL-9018519" name="Estrogen-dependent gene expression"/>
            <pathway-xref db="Reactome" id="R-BTA-113418" name="Formation of the Early Elongation Complex"/>
            <pathway-xref db="Reactome" id="R-DME-4608870" name="Asymmetric localization of PCP proteins"/>
            <pathway-xref db="MetaCyc" id="PWY-7631" name="arctigenin and isoarctigenin biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-DME-4641262" name="Disassembly of the destruction complex and recruitment of AXIN to the membrane"/>
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            <pathway-xref db="MetaCyc" id="PWY-7419" name="FR-900098 and FR-33289 antibiotics biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-DRE-8941858" name="Regulation of RUNX3 expression and activity"/>
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            <pathway-xref db="Reactome" id="R-DME-8939902" name="Regulation of RUNX2 expression and activity"/>
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            <pathway-xref db="MetaCyc" id="PWY-7930" name="pyoluteorin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-8852276" name="The role of GTSE1 in G2/M progression after G2 checkpoint"/>
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            <pathway-xref db="MetaCyc" id="PWY-7569" name="arginomycin biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-HSA-5674400" name="Constitutive Signaling by AKT1 E17K in Cancer"/>
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            <pathway-xref db="MetaCyc" id="PWY-7759" name="bacteriochlorophyll c biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-CEL-8932339" name="ROS sensing by NFE2L2"/>
            <pathway-xref db="MetaCyc" id="PWY-7817" name="type I lipoteichoic acid biosynthesis (S. aureus)"/>
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            <pathway-xref db="MetaCyc" id="PWY-7717" name="3-hydroxy-4-methyl-anthranilate biosynthesis I"/>
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            <pathway-xref db="MetaCyc" id="PWY-7655" name="dechlorogriseofulvin biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-MMU-198693" name="AKT phosphorylates targets in the nucleus"/>
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            <pathway-xref db="Reactome" id="R-MMU-174411" name="Polymerase switching on the C-strand of the telomere"/>
            <pathway-xref db="MetaCyc" id="PWY-6030" name="serotonin and melatonin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SCE-6791226" name="Major pathway of rRNA processing in the nucleolus and cytosol"/>
            <pathway-xref db="MetaCyc" id="PWY-7765" name="3-hydroxy-4-methyl-anthranilate biosynthesis II"/>
            <pathway-xref db="Reactome" id="R-DDI-2467813" name="Separation of Sister Chromatids"/>
            <pathway-xref db="MetaCyc" id="PWY-7155" name="7-dehydroporiferasterol biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-7138" name="noscapine biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-7977" name="L-methionine biosynthesis IV"/>
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            <pathway-xref db="MetaCyc" id="PWY-6407" name="yersiniabactin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-BTA-8953750" name="Transcriptional Regulation by E2F6"/>
            <pathway-xref db="Reactome" id="R-MMU-8852276" name="The role of GTSE1 in G2/M progression after G2 checkpoint"/>
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            <pathway-xref db="MetaCyc" id="PWY-7552" name="heme b biosynthesis III (from siroheme)"/>
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            <pathway-xref db="Reactome" id="R-MMU-110320" name="Translesion Synthesis by POLH"/>
            <pathway-xref db="Reactome" id="R-CEL-211163" name="AKT-mediated inactivation of FOXO1A"/>
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            <pathway-xref db="Reactome" id="R-SCE-77075" name="RNA Pol II CTD phosphorylation and interaction with CE"/>
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            <pathway-xref db="Reactome" id="R-DRE-68827" name="CDT1 association with the CDC6:ORC:origin complex"/>
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            <pathway-xref db="MetaCyc" id="PWY-7534" name="gliotoxin inactivation"/>
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            <pathway-xref db="Reactome" id="R-RNO-73776" name="RNA Polymerase II Promoter Escape"/>
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            <pathway-xref db="Reactome" id="R-DDI-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-DME-432626" name="Circadian Clock pathway"/>
            <pathway-xref db="Reactome" id="R-MMU-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
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            <pathway-xref db="Reactome" id="R-RNO-75953" name="RNA Polymerase II Transcription Initiation"/>
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            <pathway-xref db="MetaCyc" id="PWY-3581" name="(S)-reticuline biosynthesis I"/>
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            <pathway-xref db="MetaCyc" id="PWY-7649" name="3-hydroxy-L-homotyrosine biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-HSA-167161" name="HIV Transcription Initiation"/>
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            <pathway-xref db="Reactome" id="R-MMU-5685942" name="HDR through Homologous Recombination (HRR)"/>
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            <pathway-xref db="Reactome" id="R-RNO-75102" name="C6 deamination of adenosine"/>
            <pathway-xref db="Reactome" id="R-SPO-110312" name="Translesion synthesis by REV1"/>
            <pathway-xref db="Reactome" id="R-DRE-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-SPO-110314" name="Recognition of DNA damage by PCNA-containing replication complex"/>
            <pathway-xref db="MetaCyc" id="PWY-7440" name="dTDP-beta-L-4-epi-vancosamine biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-7608" name="neoxaline biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-HSA-2892247" name="POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation"/>
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            <pathway-xref db="Reactome" id="R-SSC-933541" name="TRAF6 mediated IRF7 activation"/>
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            <pathway-xref db="MetaCyc" id="PWY-6998" name="CDP-D-arabitol biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-RNO-69481" name="G2/M Checkpoints"/>
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            <pathway-xref db="Reactome" id="R-DME-917729" name="Endosomal Sorting Complex Required For Transport (ESCRT)"/>
            <pathway-xref db="Reactome" id="R-MMU-69273" name="Cyclin A/B1/B2 associated events during G2/M transition"/>
            <pathway-xref db="Reactome" id="R-DDI-76042" name="RNA Polymerase II Transcription Initiation And Promoter Clearance"/>
            <pathway-xref db="Reactome" id="R-HSA-139915" name="Activation of PUMA and translocation to mitochondria"/>
            <pathway-xref db="Reactome" id="R-DRE-198693" name="AKT phosphorylates targets in the nucleus"/>
            <pathway-xref db="Reactome" id="R-MMU-110314" name="Recognition of DNA damage by PCNA-containing replication complex"/>
            <pathway-xref db="Reactome" id="R-DME-209406" name="Degradation of NF-kappa-B inhibitor, CACT"/>
            <pathway-xref db="Reactome" id="R-SCE-75953" name="RNA Polymerase II Transcription Initiation"/>
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            <pathway-xref db="Reactome" id="R-DRE-1236978" name="Cross-presentation of soluble exogenous antigens (endosomes)"/>
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            <pathway-xref db="MetaCyc" id="PWY-8095" name="5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)"/>
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            <pathway-xref db="Reactome" id="R-RNO-5685938" name="HDR through Single Strand Annealing (SSA)"/>
            <pathway-xref db="Reactome" id="R-CFA-114608" name="Platelet degranulation"/>
            <pathway-xref db="Reactome" id="R-RNO-1169091" name="Activation of NF-kappaB in B cells"/>
            <pathway-xref db="Reactome" id="R-HSA-76042" name="RNA Polymerase II Transcription Initiation And Promoter Clearance"/>
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            <pathway-xref db="Reactome" id="R-SPO-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-2681" name="trans-zeatin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-XTR-9614399" name="Regulation of localization of FOXO transcription factors"/>
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            <pathway-xref db="Reactome" id="R-MMU-8939243" name="RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"/>
            <pathway-xref db="Reactome" id="R-DME-8939245" name="RUNX1 regulates transcription of genes involved in BCR signaling"/>
            <pathway-xref db="Reactome" id="R-CEL-2028269" name="Signaling by Hippo"/>
            <pathway-xref db="Reactome" id="R-CEL-201688" name="WNT mediated activation of DVL"/>
            <pathway-xref db="Reactome" id="R-MMU-5607764" name="CLEC7A (Dectin-1) signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-5882" name="epoxypseudoisoeugenol-2-methylbutanoate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-XTR-5663220" name="RHO GTPases Activate Formins"/>
            <pathway-xref db="Reactome" id="R-HSA-9661069" name="Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)"/>
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            <pathway-xref db="MetaCyc" id="PWY-7301" name="dTDP-4-O-demethyl-beta-L-noviose biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-RNO-6783310" name="Fanconi Anemia Pathway"/>
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            <pathway-xref db="Reactome" id="R-HSA-422356" name="Regulation of insulin secretion"/>
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            <pathway-xref db="MetaCyc" id="PWY-7723" name="bacterial bioluminescence"/>
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            <pathway-xref db="MetaCyc" id="PWY-5129" name="sphingolipid biosynthesis (plants)"/>
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            <pathway-xref db="MetaCyc" id="PWY-5706" name="alliin metabolism"/>
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            <pathway-xref db="Reactome" id="R-DME-6798695" name="Neutrophil degranulation"/>
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            <pathway-xref db="MetaCyc" id="PWY-7298" name="nevadensin biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-DME-216167" name="Nuclear CI is degraded"/>
            <pathway-xref db="MetaCyc" id="PWY-5660" name="taxol biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-6976" name="dTDP-beta-L-mycarose biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7696" name="citreoisocoumarin and bikisocoumarin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7342" name="superpathway of nicotine biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-RNO-5693616" name="Presynaptic phase of homologous DNA pairing and strand exchange"/>
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            <pathway-xref db="Reactome" id="R-RNO-5358606" name="Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)"/>
            <pathway-xref db="MetaCyc" id="PWY-8231" name="Escherichia coli serotype O:127 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-917937" name="Iron uptake and transport"/>
            <pathway-xref db="Reactome" id="R-HSA-5610780" name="Degradation of GLI1 by the proteasome"/>
            <pathway-xref db="Reactome" id="R-DRE-187577" name="SCF(Skp2)-mediated degradation of p27/p21"/>
            <pathway-xref db="Reactome" id="R-MMU-9013409" name="RHOJ GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-9013408" name="RHOG GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DDI-72086" name="mRNA Capping"/>
            <pathway-xref db="Reactome" id="R-CEL-5696394" name="DNA Damage Recognition in GG-NER"/>
            <pathway-xref db="MetaCyc" id="PWY-5883" name="ephedrine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-1660514" name="Synthesis of PIPs at the Golgi membrane"/>
            <pathway-xref db="Reactome" id="R-DME-112382" name="Formation of RNA Pol II elongation complex"/>
            <pathway-xref db="Reactome" id="R-MMU-933541" name="TRAF6 mediated IRF7 activation"/>
            <pathway-xref db="Reactome" id="R-MMU-2871837" name="FCERI mediated NF-kB activation"/>
            <pathway-xref db="Reactome" id="R-SPO-69017" name="CDK-mediated phosphorylation and removal of Cdc6"/>
            <pathway-xref db="Reactome" id="R-HSA-2470946" name="Cohesin Loading onto Chromatin"/>
            <pathway-xref db="Reactome" id="R-XTR-4086400" name="PCP/CE pathway"/>
            <pathway-xref db="Reactome" id="R-RNO-5651801" name="PCNA-Dependent Long Patch Base Excision Repair"/>
            <pathway-xref db="Reactome" id="R-HSA-9617828" name="FOXO-mediated transcription of cell cycle genes"/>
            <pathway-xref db="Reactome" id="R-MMU-68911" name="G2 Phase"/>
            <pathway-xref db="Reactome" id="R-MMU-2470946" name="Cohesin Loading onto Chromatin"/>
            <pathway-xref db="Reactome" id="R-MMU-68962" name="Activation of the pre-replicative complex"/>
            <pathway-xref db="MetaCyc" id="PWY-81" name="toluene degradation to benzoyl-CoA (anaerobic)"/>
            <pathway-xref db="Reactome" id="R-HSA-9617629" name="Regulation of FOXO transcriptional activity by acetylation"/>
            <pathway-xref db="Reactome" id="R-MMU-9617828" name="FOXO-mediated transcription of cell cycle genes"/>
            <pathway-xref db="MetaCyc" id="PWY-7532" name="acetylaszonalenin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-156827" name="L13a-mediated translational silencing of Ceruloplasmin expression"/>
            <pathway-xref db="Reactome" id="R-DDI-75955" name="RNA Polymerase II Transcription Elongation"/>
            <pathway-xref db="MetaCyc" id="PWY-6036" name="cardenolide glucosides biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-68962" name="Activation of the pre-replicative complex"/>
            <pathway-xref db="Reactome" id="R-BTA-975957" name="Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"/>
            <pathway-xref db="Reactome" id="R-SCE-76066" name="RNA Polymerase III Transcription Initiation From Type 2 Promoter"/>
            <pathway-xref db="Reactome" id="R-RNO-4641257" name="Degradation of AXIN"/>
            <pathway-xref db="Reactome" id="R-DDI-6782135" name="Dual incision in TC-NER"/>
            <pathway-xref db="Reactome" id="R-SPO-5656169" name="Termination of translesion DNA synthesis"/>
            <pathway-xref db="Reactome" id="R-DME-450728" name="Inhibition of actin polymerisation"/>
            <pathway-xref db="Reactome" id="R-XTR-5632684" name="Hedgehog 'on' state"/>
            <pathway-xref db="Reactome" id="R-HSA-69166" name="Removal of the Flap Intermediate"/>
            <pathway-xref db="Reactome" id="R-SSC-1606341" name="IRF3 mediated activation of type 1 IFN"/>
            <pathway-xref db="Reactome" id="R-HSA-9013418" name="RHOBTB2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-382556" name="ABC-family proteins mediated transport"/>
            <pathway-xref db="MetaCyc" id="PWY-7671" name="saframycin A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-174437" name="Removal of the Flap Intermediate from the C-strand"/>
            <pathway-xref db="Reactome" id="R-MMU-8932339" name="ROS sensing by NFE2L2"/>
            <pathway-xref db="Reactome" id="R-DME-5607761" name="Dectin-1 mediated noncanonical NF-kB signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9013408" name="RHOG GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-7693" name="guadinomine B biosynthesis"/>
            <pathway-xref db="Reactome" id="R-BTA-3270619" name="IRF3-mediated induction of type I IFN"/>
            <pathway-xref db="Reactome" id="R-HSA-4086400" name="PCP/CE pathway"/>
            <pathway-xref db="Reactome" id="R-DRE-349425" name="Autodegradation of the E3 ubiquitin ligase COP1"/>
            <pathway-xref db="Reactome" id="R-RNO-9705462" name="Inactivation of CSF3 (G-CSF) signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-936964" name="Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon"/>
            <pathway-xref db="Reactome" id="R-MMU-9013418" name="RHOBTB2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-CEL-5663220" name="RHO GTPases Activate Formins"/>
            <pathway-xref db="MetaCyc" id="PWY-8166" name="emodin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-72163" name="mRNA Splicing - Major Pathway"/>
            <pathway-xref db="Reactome" id="R-SPO-1236978" name="Cross-presentation of soluble exogenous antigens (endosomes)"/>
            <pathway-xref db="Reactome" id="R-MMU-9013405" name="RHOD GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-69166" name="Removal of the Flap Intermediate"/>
            <pathway-xref db="MetaCyc" id="PWY-7989" name="acinetoferrin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SPO-72649" name="Translation initiation complex formation"/>
            <pathway-xref db="MetaCyc" id="PWY-6545" name="pyrimidine deoxyribonucleotides de novo biosynthesis III"/>
            <pathway-xref db="MetaCyc" id="PWY-7677" name="rosamicin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-1362277" name="Transcription of E2F targets under negative control by DREAM complex"/>
            <pathway-xref db="MetaCyc" id="PWY-7261" name="anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)"/>
            <pathway-xref db="Reactome" id="R-HSA-6781827" name="Transcription-Coupled Nucleotide Excision Repair (TC-NER)"/>
            <pathway-xref db="Reactome" id="R-MMU-113418" name="Formation of the Early Elongation Complex"/>
            <pathway-xref db="Reactome" id="R-MMU-69231" name="Cyclin D associated events in G1"/>
            <pathway-xref db="Reactome" id="R-SPO-5687128" name="MAPK6/MAPK4 signaling"/>
            <pathway-xref db="Reactome" id="R-DRE-4641257" name="Degradation of AXIN"/>
            <pathway-xref db="Reactome" id="R-DDI-6782210" name="Gap-filling DNA repair synthesis and ligation in TC-NER"/>
            <pathway-xref db="MetaCyc" id="PWY-6739" name="pinitol biosynthesis II"/>
            <pathway-xref db="MetaCyc" id="PWY-7480" name="2,3-dihydroxybenzoate degradation"/>
            <pathway-xref db="Reactome" id="R-DME-450408" name="AUF1 (hnRNP D0) binds and destabilizes mRNA"/>
            <pathway-xref db="Reactome" id="R-SSC-918233" name="TRAF3-dependent IRF activation pathway"/>
            <pathway-xref db="Reactome" id="R-DME-72702" name="Ribosomal scanning and start codon recognition"/>
            <pathway-xref db="Reactome" id="R-DDI-2559582" name="Senescence-Associated Secretory Phenotype (SASP)"/>
            <pathway-xref db="MetaCyc" id="PWY-7112" name="4-hydroxy-2-nonenal detoxification"/>
            <pathway-xref db="MetaCyc" id="PWY-5773" name="gossypol biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-9013404" name="RAC2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-75955" name="RNA Polymerase II Transcription Elongation"/>
            <pathway-xref db="MetaCyc" id="PWY-7702" name="sch210971 and sch210972 biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-5689603" name="UCH proteinases"/>
            <pathway-xref db="Reactome" id="R-BTA-975956" name="Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"/>
            <pathway-xref db="MetaCyc" id="PWY-5479" name="6-methoxypodophyllotoxin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-9013422" name="RHOBTB1 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-6154" name="autoinducer AI-2 biosynthesis II (Vibrio)"/>
            <pathway-xref db="Reactome" id="R-HSA-8941858" name="Regulation of RUNX3 expression and activity"/>
            <pathway-xref db="Reactome" id="R-DME-202424" name="Downstream TCR signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9013148" name="CDC42 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-SPO-72689" name="Formation of a pool of free 40S subunits"/>
            <pathway-xref db="MetaCyc" id="PWY-8125" name="mevalonate pathway IV (archaea)"/>
            <pathway-xref db="Reactome" id="R-HSA-174084" name="Autodegradation of Cdh1 by Cdh1:APC/C"/>
            <pathway-xref db="Reactome" id="R-MMU-6781823" name="Formation of TC-NER Pre-Incision Complex"/>
            <pathway-xref db="MetaCyc" id="PWY-6056" name="dimethylsulfoniopropanoate degradation II (cleavage)"/>
            <pathway-xref db="Reactome" id="R-HSA-168928" name="DDX58/IFIH1-mediated induction of interferon-alpha/beta"/>
            <pathway-xref db="Reactome" id="R-HSA-8932339" name="ROS sensing by NFE2L2"/>
            <pathway-xref db="Reactome" id="R-HSA-1538133" name="G0 and Early G1"/>
            <pathway-xref db="MetaCyc" id="PWY-7452" name="cyanidin dimalonylglucoside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-5610783" name="Degradation of GLI2 by the proteasome"/>
            <pathway-xref db="Reactome" id="R-HSA-6781823" name="Formation of TC-NER Pre-Incision Complex"/>
            <pathway-xref db="MetaCyc" id="PWY-8038" name="naphthomycin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7055" name="daphnetin modification"/>
            <pathway-xref db="MetaCyc" id="PWY-7737" name="thiocoraline biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-9013148" name="CDC42 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-6807505" name="RNA polymerase II transcribes snRNA genes"/>
            <pathway-xref db="MetaCyc" id="PWY-7458" name="violdelphin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7077" name="N-acetyl-D-galactosamine degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7672" name="fusaric acid biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7529" name="CMP-N-acetyl-7-O-acetylneuraminate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-5696400" name="Dual Incision in GG-NER"/>
            <pathway-xref db="Reactome" id="R-MMU-5689603" name="UCH proteinases"/>
            <pathway-xref db="Reactome" id="R-SCE-6796648" name="TP53 Regulates Transcription of DNA Repair Genes"/>
            <pathway-xref db="Reactome" id="R-DDI-73779" name="RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"/>
            <pathway-xref db="Reactome" id="R-RNO-174411" name="Polymerase switching on the C-strand of the telomere"/>
            <pathway-xref db="Reactome" id="R-DME-5610785" name="GLI3 is processed to GLI3R by the proteasome"/>
            <pathway-xref db="MetaCyc" id="PWY-6369" name="inositol diphosphates biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DRE-350562" name="Regulation of ornithine decarboxylase (ODC)"/>
            <pathway-xref db="Reactome" id="R-RNO-75955" name="RNA Polymerase II Transcription Elongation"/>
            <pathway-xref db="Reactome" id="R-DDI-1799339" name="SRP-dependent cotranslational protein targeting to membrane"/>
            <pathway-xref db="Reactome" id="R-MMU-195253" name="Degradation of beta-catenin by the destruction complex"/>
            <pathway-xref db="MetaCyc" id="PWY-6950" name="DIMBOA-glucoside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-3371453" name="Regulation of HSF1-mediated heat shock response"/>
            <pathway-xref db="Reactome" id="R-HSA-167160" name="RNA Pol II CTD phosphorylation and interaction with CE during HIV infection"/>
            <pathway-xref db="Reactome" id="R-SCE-75955" name="RNA Polymerase II Transcription Elongation"/>
            <pathway-xref db="Reactome" id="R-DME-76061" name="RNA Polymerase III Transcription Initiation From Type 1 Promoter"/>
            <pathway-xref db="MetaCyc" id="PWY-5679" name="clavulanate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9013409" name="RHOJ GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-174178" name="APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1"/>
            <pathway-xref db="MetaCyc" id="PWY-7923" name="archaeosine biosynthesis II"/>
            <pathway-xref db="Reactome" id="R-RNO-5655862" name="Translesion synthesis by POLK"/>
            <pathway-xref db="Reactome" id="R-HSA-5362768" name="Hh mutants are degraded by ERAD"/>
            <pathway-xref db="MetaCyc" id="PWY-7741" name="phthiocerol biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-5632684" name="Hedgehog 'on' state"/>
            <pathway-xref db="Reactome" id="R-SSC-3134973" name="LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production"/>
            <pathway-xref db="MetaCyc" id="PWY-7511" name="protein ubiquitination"/>
            <pathway-xref db="Reactome" id="R-MMU-1538133" name="G0 and Early G1"/>
            <pathway-xref db="Reactome" id="R-HSA-201688" name="WNT mediated activation of DVL"/>
            <pathway-xref db="Reactome" id="R-HSA-8939256" name="RUNX1 regulates transcription of genes involved in WNT signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-8075" name="(Kdo)2-lipid A biosynthesis (P. putida)"/>
            <pathway-xref db="MetaCyc" id="PWY-7821" name="tunicamycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-2871837" name="FCERI mediated NF-kB activation"/>
            <pathway-xref db="Reactome" id="R-HSA-174414" name="Processive synthesis on the C-strand of the telomere"/>
            <pathway-xref db="Reactome" id="R-DME-72203" name="Processing of Capped Intron-Containing Pre-mRNA"/>
            <pathway-xref db="MetaCyc" id="PWY-7507" name="chelerythrine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-749476" name="RNA Polymerase III Abortive And Retractive Initiation"/>
            <pathway-xref db="Reactome" id="R-CEL-3371568" name="Attenuation phase"/>
            <pathway-xref db="Reactome" id="R-MMU-75955" name="RNA Polymerase II Transcription Elongation"/>
            <pathway-xref db="MetaCyc" id="PWY-1061" name="homogalacturonan biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-8941858" name="Regulation of RUNX3 expression and activity"/>
            <pathway-xref db="Reactome" id="R-BTA-5696394" name="DNA Damage Recognition in GG-NER"/>
            <pathway-xref db="Reactome" id="R-SCE-3371453" name="Regulation of HSF1-mediated heat shock response"/>
            <pathway-xref db="Reactome" id="R-DME-9607240" name="FLT3 Signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-176408" name="Regulation of APC/C activators between G1/S and early anaphase"/>
            <pathway-xref db="Reactome" id="R-SPO-8854050" name="FBXL7 down-regulates AURKA during mitotic entry and in early mitosis"/>
            <pathway-xref db="Reactome" id="R-HSA-168325" name="Viral Messenger RNA Synthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7265" name="lampranthin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-382556" name="ABC-family proteins mediated transport"/>
            <pathway-xref db="Reactome" id="R-MMU-6803529" name="FGFR2 alternative splicing"/>
            <pathway-xref db="Reactome" id="R-MMU-1170546" name="Prolactin receptor signaling"/>
            <pathway-xref db="Reactome" id="R-SPO-5655862" name="Translesion synthesis by POLK"/>
            <pathway-xref db="Reactome" id="R-SCE-68689" name="CDC6 association with the ORC:origin complex"/>
            <pathway-xref db="Reactome" id="R-HSA-9013406" name="RHOQ GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-1170546" name="Prolactin receptor signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-8104" name="yangonin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7818" name="type IV lipoteichoic acid biosynthesis (S. pneumoniae)"/>
            <pathway-xref db="Reactome" id="R-MMU-1169408" name="ISG15 antiviral mechanism"/>
            <pathway-xref db="Reactome" id="R-MMU-5668541" name="TNFR2 non-canonical NF-kB pathway"/>
            <pathway-xref db="Reactome" id="R-HSA-8939247" name="RUNX1 regulates transcription of genes involved in interleukin signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-76066" name="RNA Polymerase III Transcription Initiation From Type 2 Promoter"/>
            <pathway-xref db="Reactome" id="R-HSA-6796648" name="TP53 Regulates Transcription of DNA Repair Genes"/>
            <pathway-xref db="MetaCyc" id="PWY-7624" name="nystatin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5871" name="ubiquinol-9 biosynthesis (late decarboxylation)"/>
            <pathway-xref db="Reactome" id="R-MMU-350562" name="Regulation of ornithine decarboxylase (ODC)"/>
            <pathway-xref db="MetaCyc" id="PWY-6397" name="mycolyl-arabinogalactan-peptidoglycan complex biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SSC-9013422" name="RHOBTB1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DME-198693" name="AKT phosphorylates targets in the nucleus"/>
            <pathway-xref db="Reactome" id="R-HSA-9607240" name="FLT3 Signaling"/>
            <pathway-xref db="Reactome" id="R-DDI-1236978" name="Cross-presentation of soluble exogenous antigens (endosomes)"/>
            <pathway-xref db="MetaCyc" id="PWY-7601" name="arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)"/>
            <pathway-xref db="Reactome" id="R-HSA-6803529" name="FGFR2 alternative splicing"/>
            <pathway-xref db="Reactome" id="R-MMU-2467813" name="Separation of Sister Chromatids"/>
            <pathway-xref db="Reactome" id="R-DDI-174084" name="Autodegradation of Cdh1 by Cdh1:APC/C"/>
            <pathway-xref db="Reactome" id="R-DDI-975956" name="Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"/>
            <pathway-xref db="Reactome" id="R-DME-5610780" name="Degradation of GLI1 by the proteasome"/>
            <pathway-xref db="Reactome" id="R-HSA-69473" name="G2/M DNA damage checkpoint"/>
            <pathway-xref db="Reactome" id="R-DME-432524" name="Degradation of PER"/>
            <pathway-xref db="Reactome" id="R-HSA-6804114" name="TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest"/>
            <pathway-xref db="Reactome" id="R-DDI-76066" name="RNA Polymerase III Transcription Initiation From Type 2 Promoter"/>
            <pathway-xref db="Reactome" id="R-DRE-8854050" name="FBXL7 down-regulates AURKA during mitotic entry and in early mitosis"/>
            <pathway-xref db="Reactome" id="R-RNO-8951664" name="Neddylation"/>
            <pathway-xref db="Reactome" id="R-HSA-2467813" name="Separation of Sister Chromatids"/>
            <pathway-xref db="MetaCyc" id="PWY-8212" name="Escherichia coli serotype O:8 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-392517" name="Rap1 signalling"/>
            <pathway-xref db="Reactome" id="R-HSA-5668541" name="TNFR2 non-canonical NF-kB pathway"/>
            <pathway-xref db="MetaCyc" id="PWY-7983" name="pseudomonine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5400" name="amaranthin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SCE-1799339" name="SRP-dependent cotranslational protein targeting to membrane"/>
            <pathway-xref db="Reactome" id="R-GGA-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-GGA-72702" name="Ribosomal scanning and start codon recognition"/>
            <pathway-xref db="Reactome" id="R-SCE-2500257" name="Resolution of Sister Chromatid Cohesion"/>
            <pathway-xref db="Reactome" id="R-MMU-5696397" name="Gap-filling DNA repair synthesis and ligation in GG-NER"/>
            <pathway-xref db="Reactome" id="R-SPO-917937" name="Iron uptake and transport"/>
            <pathway-xref db="Reactome" id="R-CEL-156827" name="L13a-mediated translational silencing of Ceruloplasmin expression"/>
            <pathway-xref db="Reactome" id="R-HSA-9639288" name="Amino acids regulate mTORC1"/>
            <pathway-xref db="Reactome" id="R-RNO-6791226" name="Major pathway of rRNA processing in the nucleolus and cytosol"/>
            <pathway-xref db="Reactome" id="R-SCE-72086" name="mRNA Capping"/>
            <pathway-xref db="MetaCyc" id="PWY-6322" name="phosphinothricin tripeptide biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-68911" name="G2 Phase"/>
            <pathway-xref db="Reactome" id="R-HSA-69231" name="Cyclin D associated events in G1"/>
            <pathway-xref db="Reactome" id="R-MMU-9607240" name="FLT3 Signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-5710" name="capsaicin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SPO-69601" name="Ubiquitin Mediated Degradation of Phosphorylated Cdc25A"/>
            <pathway-xref db="Reactome" id="R-CEL-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-CEL-9634638" name="Estrogen-dependent nuclear events downstream of ESR-membrane signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-5437" name="L-threonine degradation I"/>
            <pathway-xref db="Reactome" id="R-HSA-202424" name="Downstream TCR signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-7474" name="avenacin A-2 biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-5696395" name="Formation of Incision Complex in GG-NER"/>
            <pathway-xref db="Reactome" id="R-BTA-9013973" name="TICAM1-dependent activation of IRF3/IRF7"/>
            <pathway-xref db="Reactome" id="R-DDI-6803529" name="FGFR2 alternative splicing"/>
            <pathway-xref db="Reactome" id="R-HSA-5685938" name="HDR through Single Strand Annealing (SSA)"/>
            <pathway-xref db="Reactome" id="R-DME-2151201" name="Transcriptional activation of mitochondrial biogenesis"/>
            <pathway-xref db="Reactome" id="R-SPO-72702" name="Ribosomal scanning and start codon recognition"/>
            <pathway-xref db="Reactome" id="R-DDI-9018519" name="Estrogen-dependent gene expression"/>
            <pathway-xref db="MetaCyc" id="PWY-7533" name="gliotoxin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-4086400" name="PCP/CE pathway"/>
            <pathway-xref db="Reactome" id="R-SPO-72165" name="mRNA Splicing - Minor Pathway"/>
            <pathway-xref db="Reactome" id="R-RNO-354192" name="Integrin signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-1221632" name="Meiotic synapsis"/>
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            <pathway-xref db="Reactome" id="R-RNO-8854050" name="FBXL7 down-regulates AURKA during mitotic entry and in early mitosis"/>
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            <pathway-xref db="Reactome" id="R-DME-350562" name="Regulation of ornithine decarboxylase (ODC)"/>
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            <pathway-xref db="MetaCyc" id="PWY-7172" name="flavonol acylglucoside biosynthesis III - quercetin derivatives"/>
            <pathway-xref db="MetaCyc" id="PWY-6314" name="plumbagin biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-MMU-69166" name="Removal of the Flap Intermediate"/>
            <pathway-xref db="Reactome" id="R-MMU-3134973" name="LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production"/>
            <pathway-xref db="Reactome" id="R-GGA-2559585" name="Oncogene Induced Senescence"/>
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            <pathway-xref db="Reactome" id="R-SSC-9013973" name="TICAM1-dependent activation of IRF3/IRF7"/>
            <pathway-xref db="MetaCyc" id="PWY-6032" name="digitoxigenin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-9639288" name="Amino acids regulate mTORC1"/>
            <pathway-xref db="Reactome" id="R-DRE-8951664" name="Neddylation"/>
            <pathway-xref db="Reactome" id="R-SPO-73776" name="RNA Polymerase II Promoter Escape"/>
            <pathway-xref db="MetaCyc" id="PWY-7473" name="avenacin A-1 biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-RNO-72706" name="GTP hydrolysis and joining of the 60S ribosomal subunit"/>
            <pathway-xref db="MetaCyc" id="PWY-7716" name="penicillin G and penicillin V biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-8939247" name="RUNX1 regulates transcription of genes involved in interleukin signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-6796648" name="TP53 Regulates Transcription of DNA Repair Genes"/>
            <pathway-xref db="Reactome" id="R-HSA-167172" name="Transcription of the HIV genome"/>
            <pathway-xref db="Reactome" id="R-SPO-75953" name="RNA Polymerase II Transcription Initiation"/>
            <pathway-xref db="MetaCyc" id="PWY-5059" name="pinobanksin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5024" name="L-arginine degradation XI"/>
            <pathway-xref db="Reactome" id="R-SPO-68867" name="Assembly of the pre-replicative complex"/>
            <pathway-xref db="Reactome" id="R-HSA-3134973" name="LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production"/>
            <pathway-xref db="MetaCyc" id="PWY-7475" name="des-methyl avenacin A-1 biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6835" name="6-gingerol biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-174184" name="Cdc20:Phospho-APC/C mediated degradation of Cyclin A"/>
            <pathway-xref db="Reactome" id="R-DME-9617629" name="Regulation of FOXO transcriptional activity by acetylation"/>
            <pathway-xref db="Reactome" id="R-DME-8856828" name="Clathrin-mediated endocytosis"/>
            <pathway-xref db="MetaCyc" id="PWY-1121" name="suberin monomers biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-9607240" name="FLT3 Signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-9634638" name="Estrogen-dependent nuclear events downstream of ESR-membrane signaling"/>
            <pathway-xref db="Reactome" id="R-SCE-69166" name="Removal of the Flap Intermediate"/>
            <pathway-xref db="Reactome" id="R-DME-8932339" name="ROS sensing by NFE2L2"/>
            <pathway-xref db="Reactome" id="R-RNO-209931" name="Serotonin and melatonin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-156711" name="Polo-like kinase mediated events"/>
            <pathway-xref db="MetaCyc" id="PWY-7045" name="mithramycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DDI-917729" name="Endosomal Sorting Complex Required For Transport (ESCRT)"/>
            <pathway-xref db="Reactome" id="R-RNO-2559584" name="Formation of Senescence-Associated Heterochromatin Foci (SAHF)"/>
            <pathway-xref db="MetaCyc" id="PWY-7230" name="ubiquinol-6 biosynthesis from 4-aminobenzoate (yeast)"/>
            <pathway-xref db="Reactome" id="R-BTA-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-RNO-114608" name="Platelet degranulation"/>
            <pathway-xref db="Reactome" id="R-SCE-5687128" name="MAPK6/MAPK4 signaling"/>
            <pathway-xref db="Reactome" id="R-DME-72165" name="mRNA Splicing - Minor Pathway"/>
            <pathway-xref db="Reactome" id="R-RNO-68962" name="Activation of the pre-replicative complex"/>
            <pathway-xref db="Reactome" id="R-MMU-9013106" name="RHOC GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-3134963" name="DEx/H-box helicases activate type I IFN and inflammatory cytokines production"/>
            <pathway-xref db="Reactome" id="R-HSA-2644607" name="Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling"/>
            <pathway-xref db="Reactome" id="R-DME-73776" name="RNA Polymerase II Promoter Escape"/>
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            <pathway-xref db="Reactome" id="R-CEL-198693" name="AKT phosphorylates targets in the nucleus"/>
            <pathway-xref db="Reactome" id="R-HSA-6804116" name="TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest"/>
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            <pathway-xref db="Reactome" id="R-RNO-110312" name="Translesion synthesis by REV1"/>
            <pathway-xref db="Reactome" id="R-HSA-8856828" name="Clathrin-mediated endocytosis"/>
            <pathway-xref db="MetaCyc" id="PWY-5473" name="hydroxycinnamic acid serotonin amides biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-179409" name="APC-Cdc20 mediated degradation of Nek2A"/>
            <pathway-xref db="MetaCyc" id="PWY-7079" name="geodin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-975956" name="Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"/>
            <pathway-xref db="Reactome" id="R-MMU-72086" name="mRNA Capping"/>
            <pathway-xref db="Reactome" id="R-HSA-3134975" name="Regulation of innate immune responses to cytosolic DNA"/>
            <pathway-xref db="Reactome" id="R-DME-350480" name="Activation of non-muscle Myosin II"/>
            <pathway-xref db="Reactome" id="R-RNO-5696394" name="DNA Damage Recognition in GG-NER"/>
            <pathway-xref db="Reactome" id="R-HSA-68911" name="G2 Phase"/>
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            <pathway-xref db="MetaCyc" id="PWY-7800" name="Ac/N-end rule pathway"/>
            <pathway-xref db="Reactome" id="R-MMU-4086400" name="PCP/CE pathway"/>
            <pathway-xref db="Reactome" id="R-MMU-3134975" name="Regulation of innate immune responses to cytosolic DNA"/>
            <pathway-xref db="Reactome" id="R-RNO-1912408" name="Pre-NOTCH Transcription and Translation"/>
            <pathway-xref db="MetaCyc" id="PWY-6378" name="putrebactin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DRE-195253" name="Degradation of beta-catenin by the destruction complex"/>
            <pathway-xref db="Reactome" id="R-DME-75953" name="RNA Polymerase II Transcription Initiation"/>
            <pathway-xref db="Reactome" id="R-DDI-9706019" name="RHOBTB3 ATPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-73779" name="RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"/>
            <pathway-xref db="Reactome" id="R-RNO-69473" name="G2/M DNA damage checkpoint"/>
            <pathway-xref db="Reactome" id="R-RNO-110314" name="Recognition of DNA damage by PCNA-containing replication complex"/>
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            <pathway-xref db="Reactome" id="R-DME-382556" name="ABC-family proteins mediated transport"/>
            <pathway-xref db="MetaCyc" id="PWY-7738" name="polyacyltrehalose biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-6798695" name="Neutrophil degranulation"/>
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            <pathway-xref db="Reactome" id="R-MMU-8856828" name="Clathrin-mediated endocytosis"/>
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            <pathway-xref db="Reactome" id="R-MMU-3371511" name="HSF1 activation"/>
            <pathway-xref db="MetaCyc" id="PWY-6325" name="echinatin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-75815" name="Ubiquitin-dependent degradation of Cyclin D"/>
            <pathway-xref db="Reactome" id="R-DME-538864" name="Degradation of CRY"/>
            <pathway-xref db="Reactome" id="R-DDI-176409" name="APC/C:Cdc20 mediated degradation of mitotic proteins"/>
            <pathway-xref db="MetaCyc" id="PWY-8058" name="2-deoxy-D-ribose degradation II"/>
            <pathway-xref db="Reactome" id="R-MMU-5685938" name="HDR through Single Strand Annealing (SSA)"/>
            <pathway-xref db="Reactome" id="R-RNO-75815" name="Ubiquitin-dependent degradation of Cyclin D"/>
            <pathway-xref db="MetaCyc" id="PWY-7577" name="ferrichrome biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DDI-4641258" name="Degradation of DVL"/>
            <pathway-xref db="MetaCyc" id="PWY-8085" name="picolinate degradation"/>
            <pathway-xref db="Reactome" id="R-DDI-6796648" name="TP53 Regulates Transcription of DNA Repair Genes"/>
            <pathway-xref db="Reactome" id="R-CEL-350562" name="Regulation of ornithine decarboxylase (ODC)"/>
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            <pathway-xref db="Reactome" id="R-DME-432395" name="Degradation of TIM"/>
            <pathway-xref db="Reactome" id="R-HSA-3371511" name="HSF1 activation"/>
            <pathway-xref db="Reactome" id="R-HSA-8851708" name="Signaling by FGFR2 IIIa TM"/>
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            <pathway-xref db="Reactome" id="R-HSA-5610785" name="GLI3 is processed to GLI3R by the proteasome"/>
            <pathway-xref db="Reactome" id="R-DRE-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="MetaCyc" id="PWY-6055" name="dimethylsulfoniopropanoate biosynthesis II (Spartina)"/>
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            <pathway-xref db="Reactome" id="R-HSA-917729" name="Endosomal Sorting Complex Required For Transport (ESCRT)"/>
            <pathway-xref db="Reactome" id="R-RNO-174084" name="Autodegradation of Cdh1 by Cdh1:APC/C"/>
            <pathway-xref db="MetaCyc" id="PWY-2181" name="free phenylpropanoid acid biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-2644606" name="Constitutive Signaling by NOTCH1 PEST Domain Mutants"/>
            <pathway-xref db="MetaCyc" id="PWY-8210" name="pyrrolomycin biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-DRE-9013422" name="RHOBTB1 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-5292" name="vindoline, vindorosine and vinblastine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-3270619" name="IRF3-mediated induction of type I IFN"/>
            <pathway-xref db="Reactome" id="R-HSA-1169408" name="ISG15 antiviral mechanism"/>
            <pathway-xref db="Reactome" id="R-DRE-450408" name="AUF1 (hnRNP D0) binds and destabilizes mRNA"/>
            <pathway-xref db="MetaCyc" id="PWY-8039" name="mitomycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-674695" name="RNA Polymerase II Pre-transcription Events"/>
            <pathway-xref db="MetaCyc" id="PWY-7907" name="(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-422356" name="Regulation of insulin secretion"/>
            <pathway-xref db="Reactome" id="R-HSA-75815" name="Ubiquitin-dependent degradation of Cyclin D"/>
            <pathway-xref db="Reactome" id="R-SCE-6782135" name="Dual incision in TC-NER"/>
            <pathway-xref db="Reactome" id="R-HSA-6785807" name="Interleukin-4 and Interleukin-13 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-7555" name="alpha-cyclopiazonate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9013106" name="RHOC GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-CEL-8856828" name="Clathrin-mediated endocytosis"/>
            <pathway-xref db="MetaCyc" id="PWY-7735" name="echinomycin and triostin A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DDI-917937" name="Iron uptake and transport"/>
            <pathway-xref db="Reactome" id="R-DRE-5676590" name="NIK--&gt;noncanonical NF-kB signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-7154" name="ergosterol biosynthesis II"/>
            <pathway-xref db="Reactome" id="R-HSA-909733" name="Interferon alpha/beta signaling"/>
            <pathway-xref db="Reactome" id="R-BTA-936440" name="Negative regulators of DDX58/IFIH1 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-209931" name="Serotonin and melatonin biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-DME-4641257" name="Degradation of AXIN"/>
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            <pathway-xref db="Reactome" id="R-HSA-6782135" name="Dual incision in TC-NER"/>
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            <pathway-xref db="Reactome" id="R-RNO-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
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            <pathway-xref db="Reactome" id="R-DME-68827" name="CDT1 association with the CDC6:ORC:origin complex"/>
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            <pathway-xref db="Reactome" id="R-HSA-2151201" name="Transcriptional activation of mitochondrial biogenesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-6948" name="sitosterol degradation to androstenedione"/>
            <pathway-xref db="Reactome" id="R-RNO-2514859" name="Inactivation, recovery and regulation of the phototransduction cascade"/>
            <pathway-xref db="MetaCyc" id="PWY-7100" name="spinosyn A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-8939243" name="RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"/>
            <pathway-xref db="Reactome" id="R-RNO-5610785" name="GLI3 is processed to GLI3R by the proteasome"/>
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            <pathway-xref db="Reactome" id="R-DME-113418" name="Formation of the Early Elongation Complex"/>
            <pathway-xref db="MetaCyc" id="PWY-8077" name="ginkgotoxin biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-8179" name="platensimycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-9013422" name="RHOBTB1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-5693568" name="Resolution of D-loop Structures through Holliday Junction Intermediates"/>
            <pathway-xref db="Reactome" id="R-HSA-9013404" name="RAC2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-4641262" name="Disassembly of the destruction complex and recruitment of AXIN to the membrane"/>
            <pathway-xref db="Reactome" id="R-DRE-174184" name="Cdc20:Phospho-APC/C mediated degradation of Cyclin A"/>
            <pathway-xref db="Reactome" id="R-HSA-1234176" name="Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha"/>
            <pathway-xref db="MetaCyc" id="PWY-7861" name="N-hydroxy-L-pipecolate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SSC-3270619" name="IRF3-mediated induction of type I IFN"/>
            <pathway-xref db="Reactome" id="R-MMU-209931" name="Serotonin and melatonin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8103" name="kavain biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-975957" name="Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"/>
            <pathway-xref db="Reactome" id="R-MMU-8939236" name="RUNX1 regulates transcription of genes involved in differentiation of HSCs"/>
            <pathway-xref db="Reactome" id="R-HSA-5693554" name="Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA)"/>
            <pathway-xref db="Reactome" id="R-SPO-68827" name="CDT1 association with the CDC6:ORC:origin complex"/>
            <pathway-xref db="MetaCyc" id="PWY-7483" name="elloramycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-8948751" name="Regulation of PTEN stability and activity"/>
            <pathway-xref db="Reactome" id="R-RNO-5693607" name="Processing of DNA double-strand break ends"/>
            <pathway-xref db="MetaCyc" id="PWY-3385" name="choline biosynthesis I"/>
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            <pathway-xref db="Reactome" id="R-HSA-5607764" name="CLEC7A (Dectin-1) signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-174154" name="APC/C:Cdc20 mediated degradation of Securin"/>
            <pathway-xref db="Reactome" id="R-RNO-418594" name="G alpha (i) signalling events"/>
            <pathway-xref db="MetaCyc" id="PWY-7564" name="bacimethrin and bacimethrin pyrophosphate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8040" name="ansatrienin biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-SPO-3371571" name="HSF1-dependent transactivation"/>
            <pathway-xref db="Reactome" id="R-SCE-674695" name="RNA Polymerase II Pre-transcription Events"/>
            <pathway-xref db="Reactome" id="R-DME-6796648" name="TP53 Regulates Transcription of DNA Repair Genes"/>
            <pathway-xref db="Reactome" id="R-MMU-9013424" name="RHOV GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-195253" name="Degradation of beta-catenin by the destruction complex"/>
            <pathway-xref db="Reactome" id="R-CEL-72695" name="Formation of the ternary complex, and subsequently, the 43S complex"/>
            <pathway-xref db="Reactome" id="R-MMU-2468052" name="Establishment of Sister Chromatid Cohesion"/>
            <pathway-xref db="Reactome" id="R-HSA-176412" name="Phosphorylation of the APC/C"/>
            <pathway-xref db="Reactome" id="R-DRE-72695" name="Formation of the ternary complex, and subsequently, the 43S complex"/>
            <pathway-xref db="MetaCyc" id="PWY-5316" name="nicotine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-450408" name="AUF1 (hnRNP D0) binds and destabilizes mRNA"/>
            <pathway-xref db="Reactome" id="R-MMU-909733" name="Interferon alpha/beta signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-2500257" name="Resolution of Sister Chromatid Cohesion"/>
            <pathway-xref db="Reactome" id="R-CEL-349425" name="Autodegradation of the E3 ubiquitin ligase COP1"/>
            <pathway-xref db="Reactome" id="R-HSA-176409" name="APC/C:Cdc20 mediated degradation of mitotic proteins"/>
            <pathway-xref db="Reactome" id="R-SCE-5656121" name="Translesion synthesis by POLI"/>
            <pathway-xref db="Reactome" id="R-MMU-3214858" name="RMTs methylate histone arginines"/>
            <pathway-xref db="Reactome" id="R-DME-6803529" name="FGFR2 alternative splicing"/>
            <pathway-xref db="MetaCyc" id="PWY-6153" name="autoinducer AI-2 biosynthesis I"/>
            <pathway-xref db="MetaCyc" id="PWY-7727" name="docosahexaenoate biosynthesis IV (4-desaturase, mammals)"/>
            <pathway-xref db="Reactome" id="R-CEL-9706019" name="RHOBTB3 ATPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-5687128" name="MAPK6/MAPK4 signaling"/>
            <pathway-xref db="Reactome" id="R-SPO-9018519" name="Estrogen-dependent gene expression"/>
            <pathway-xref db="Reactome" id="R-DME-350368" name="Activation of RHO1 by FZ:DSH complex"/>
            <pathway-xref db="Reactome" id="R-DME-3371568" name="Attenuation phase"/>
            <pathway-xref db="MetaCyc" id="PWY-6312" name="barbaloin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-176187" name="Activation of ATR in response to replication stress"/>
            <pathway-xref db="Reactome" id="R-HSA-8939902" name="Regulation of RUNX2 expression and activity"/>
            <pathway-xref db="MetaCyc" id="PWY-761" name="rhizobactin 1021 biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7673" name="fusarin C biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-392517" name="Rap1 signalling"/>
            <pathway-xref db="Reactome" id="R-HSA-1660517" name="Synthesis of PIPs at the late endosome membrane"/>
            <pathway-xref db="Reactome" id="R-RNO-4086400" name="PCP/CE pathway"/>
            <pathway-xref db="Reactome" id="R-DDI-6807505" name="RNA polymerase II transcribes snRNA genes"/>
            <pathway-xref db="Reactome" id="R-MMU-6804116" name="TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest"/>
            <pathway-xref db="Reactome" id="R-DDI-75815" name="Ubiquitin-dependent degradation of Cyclin D"/>
            <pathway-xref db="Reactome" id="R-SPO-174113" name="SCF-beta-TrCP mediated degradation of Emi1"/>
            <pathway-xref db="MetaCyc" id="PWY-7563" name="bassianin and desmethylbassianin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-3542" name="choline biosynthesis II"/>
            <pathway-xref db="Reactome" id="R-MMU-176407" name="Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase"/>
            <pathway-xref db="MetaCyc" id="PWY-6672" name="cis-geranyl-CoA degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-5696394" name="DNA Damage Recognition in GG-NER"/>
            <pathway-xref db="Reactome" id="R-CEL-5632684" name="Hedgehog 'on' state"/>
            <pathway-xref db="Reactome" id="R-RNO-68689" name="CDC6 association with the ORC:origin complex"/>
            <pathway-xref db="Reactome" id="R-SPO-5358606" name="Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)"/>
            <pathway-xref db="MetaCyc" id="PWY-6722" name="candicidin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7161" name="polymethylated quercetin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-1799339" name="SRP-dependent cotranslational protein targeting to membrane"/>
            <pathway-xref db="Reactome" id="R-HSA-9018519" name="Estrogen-dependent gene expression"/>
            <pathway-xref db="Reactome" id="R-SCE-5668541" name="TNFR2 non-canonical NF-kB pathway"/>
            <pathway-xref db="Reactome" id="R-HSA-6804756" name="Regulation of TP53 Activity through Phosphorylation"/>
            <pathway-xref db="Reactome" id="R-SSC-168928" name="DDX58/IFIH1-mediated induction of interferon-alpha/beta"/>
            <pathway-xref db="Reactome" id="R-RNO-113418" name="Formation of the Early Elongation Complex"/>
            <pathway-xref db="Reactome" id="R-RNO-76042" name="RNA Polymerase II Transcription Initiation And Promoter Clearance"/>
            <pathway-xref db="MetaCyc" id="PWY-6148" name="tetrahydromethanopterin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-917937" name="Iron uptake and transport"/>
            <pathway-xref db="Reactome" id="R-MMU-72695" name="Formation of the ternary complex, and subsequently, the 43S complex"/>
            <pathway-xref db="Reactome" id="R-SPO-917729" name="Endosomal Sorting Complex Required For Transport (ESCRT)"/>
            <pathway-xref db="MetaCyc" id="PWY-5105" name="hesperitin glycoside biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5875" name="staphyloxanthin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DDI-209931" name="Serotonin and melatonin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-8853884" name="Transcriptional Regulation by VENTX"/>
            <pathway-xref db="MetaCyc" id="PWY-4922" name="6-methoxymellein biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-8951664" name="Neddylation"/>
            <pathway-xref db="Reactome" id="R-CEL-9013406" name="RHOQ GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DRE-69481" name="G2/M Checkpoints"/>
            <pathway-xref db="MetaCyc" id="PWY-7729" name="5,6-dimethylbenzimidazole biosynthesis II (anaerobic)"/>
            <pathway-xref db="MetaCyc" id="PWY-8157" name="avenanthramide biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6316" name="aromatic polyketides biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-9617828" name="FOXO-mediated transcription of cell cycle genes"/>
            <pathway-xref db="MetaCyc" id="PWY-5284" name="shisonin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-201681" name="TCF dependent signaling in response to WNT"/>
            <pathway-xref db="Reactome" id="R-HSA-110320" name="Translesion Synthesis by POLH"/>
            <pathway-xref db="MetaCyc" id="PWY-7050" name="icosapentaenoate biosynthesis IV (bacteria)"/>
            <pathway-xref db="Reactome" id="R-DDI-5689603" name="UCH proteinases"/>
            <pathway-xref db="MetaCyc" id="PWY-5870" name="ubiquinol-8 biosynthesis (late decarboxylation)"/>
            <pathway-xref db="Reactome" id="R-BTA-69231" name="Cyclin D associated events in G1"/>
            <pathway-xref db="MetaCyc" id="PWYG-321" name="mycolate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-2083" name="isoflavonoid biosynthesis II"/>
            <pathway-xref db="Reactome" id="R-SPO-6782135" name="Dual incision in TC-NER"/>
            <pathway-xref db="MetaCyc" id="PWY-7485" name="tetracenomycin C biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8084" name="daurichromenate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-6814122" name="Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"/>
            <pathway-xref db="Reactome" id="R-CEL-9013405" name="RHOD GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DRE-382556" name="ABC-family proteins mediated transport"/>
            <pathway-xref db="Reactome" id="R-MMU-5607761" name="Dectin-1 mediated noncanonical NF-kB signaling"/>
            <pathway-xref db="Reactome" id="R-CEL-9035034" name="RHOF GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DRE-156827" name="L13a-mediated translational silencing of Ceruloplasmin expression"/>
            <pathway-xref db="Reactome" id="R-HSA-3371571" name="HSF1-dependent transactivation"/>
            <pathway-xref db="Reactome" id="R-MMU-68827" name="CDT1 association with the CDC6:ORC:origin complex"/>
            <pathway-xref db="Reactome" id="R-MMU-6782210" name="Gap-filling DNA repair synthesis and ligation in TC-NER"/>
            <pathway-xref db="Reactome" id="R-SCE-176187" name="Activation of ATR in response to replication stress"/>
            <pathway-xref db="MetaCyc" id="PWY-6922" name="L-Ndelta-acetylornithine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5846" name="colchicine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5313" name="superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)"/>
            <pathway-xref db="Reactome" id="R-CEL-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-MMU-450408" name="AUF1 (hnRNP D0) binds and destabilizes mRNA"/>
            <pathway-xref db="Reactome" id="R-MMU-76042" name="RNA Polymerase II Transcription Initiation And Promoter Clearance"/>
            <pathway-xref db="Reactome" id="R-HSA-354192" name="Integrin signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-5656121" name="Translesion synthesis by POLI"/>
            <pathway-xref db="MetaCyc" id="PWY-7104" name="dTDP-beta-L-megosamine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7708" name="lyngbyatoxin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-BTA-1606341" name="IRF3 mediated activation of type 1 IFN"/>
            <pathway-xref db="Reactome" id="R-SCE-3232118" name="SUMOylation of transcription factors"/>
            <pathway-xref db="Reactome" id="R-HSA-1236974" name="ER-Phagosome pathway"/>
            <pathway-xref db="Reactome" id="R-MMU-174430" name="Telomere C-strand synthesis initiation"/>
            <pathway-xref db="Reactome" id="R-DME-69601" name="Ubiquitin Mediated Degradation of Phosphorylated Cdc25A"/>
            <pathway-xref db="Reactome" id="R-BTA-674695" name="RNA Polymerase II Pre-transcription Events"/>
            <pathway-xref db="MetaCyc" id="PWY-7661" name="protein N-glycosylation (Haloferax volcanii)"/>
            <pathway-xref db="Reactome" id="R-MMU-141430" name="Inactivation of APC/C via direct inhibition of the APC/C complex"/>
            <pathway-xref db="Reactome" id="R-DDI-176412" name="Phosphorylation of the APC/C"/>
            <pathway-xref db="Reactome" id="R-HSA-72702" name="Ribosomal scanning and start codon recognition"/>
            <pathway-xref db="Reactome" id="R-RNO-975957" name="Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"/>
            <pathway-xref db="Reactome" id="R-HSA-72695" name="Formation of the ternary complex, and subsequently, the 43S complex"/>
            <pathway-xref db="Reactome" id="R-DME-1181150" name="Signaling by NODAL"/>
            <pathway-xref db="MetaCyc" id="PWY-6427" name="rot-2'-enonate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7931" name="brominated pyrroles biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8117" name="colibactin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-68827" name="CDT1 association with the CDC6:ORC:origin complex"/>
            <pathway-xref db="MetaCyc" id="PWY-5872" name="ubiquinol-10 biosynthesis (late decarboxylation)"/>
            <pathway-xref db="MetaCyc" id="PWY-7029" name="terminal olefins biosynthesis II"/>
            <pathway-xref db="MetaCyc" id="PWY-7670" name="fusaridione A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-176412" name="Phosphorylation of the APC/C"/>
            <pathway-xref db="Reactome" id="R-MMU-8939245" name="RUNX1 regulates transcription of genes involved in BCR signaling"/>
            <pathway-xref db="Reactome" id="R-DME-72695" name="Formation of the ternary complex, and subsequently, the 43S complex"/>
            <pathway-xref db="Reactome" id="R-DDI-5673001" name="RAF/MAP kinase cascade"/>
            <pathway-xref db="Reactome" id="R-MMU-9035034" name="RHOF GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-GGA-1227882" name="TRAF mediated activation of IRF"/>
            <pathway-xref db="MetaCyc" id="PWY-6736" name="sulfur volatiles biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-198693" name="AKT phosphorylates targets in the nucleus"/>
            <pathway-xref db="Reactome" id="R-CEL-5696395" name="Formation of Incision Complex in GG-NER"/>
            <pathway-xref db="Reactome" id="R-HSA-9013973" name="TICAM1-dependent activation of IRF3/IRF7"/>
            <pathway-xref db="MetaCyc" id="PWY-7694" name="zwittermicin A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SCE-76042" name="RNA Polymerase II Transcription Initiation And Promoter Clearance"/>
            <pathway-xref db="Reactome" id="R-HSA-1606322" name="ZBP1(DAI) mediated induction of type I IFNs"/>
            <pathway-xref db="Reactome" id="R-DDI-72702" name="Ribosomal scanning and start codon recognition"/>
            <pathway-xref db="Reactome" id="R-MMU-9013406" name="RHOQ GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-7150" name="polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)"/>
            <pathway-xref db="Reactome" id="R-DRE-917729" name="Endosomal Sorting Complex Required For Transport (ESCRT)"/>
            <pathway-xref db="Reactome" id="R-MMU-381676" name="Glucagon-like Peptide-1 (GLP1) regulates insulin secretion"/>
            <pathway-xref db="Reactome" id="R-HSA-4608870" name="Asymmetric localization of PCP proteins"/>
            <pathway-xref db="Reactome" id="R-DME-1234176" name="Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha"/>
            <pathway-xref db="Reactome" id="R-SPO-1799339" name="SRP-dependent cotranslational protein targeting to membrane"/>
            <pathway-xref db="MetaCyc" id="PWY-5139" name="pelargonidin conjugates biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-1538133" name="G0 and Early G1"/>
            <pathway-xref db="Reactome" id="R-HSA-8862803" name="Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models"/>
            <pathway-xref db="MetaCyc" id="PWY-7151" name="polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)"/>
            <pathway-xref db="Reactome" id="R-DME-77075" name="RNA Pol II CTD phosphorylation and interaction with CE"/>
            <pathway-xref db="Reactome" id="R-HSA-3371568" name="Attenuation phase"/>
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            <pathway-xref db="Reactome" id="R-DDI-75953" name="RNA Polymerase II Transcription Initiation"/>
            <pathway-xref db="MetaCyc" id="PWY-5477" name="gallotannin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-110320" name="Translesion Synthesis by POLH"/>
            <pathway-xref db="Reactome" id="R-RNO-8939236" name="RUNX1 regulates transcription of genes involved in differentiation of HSCs"/>
            <pathway-xref db="Reactome" id="R-SCE-6807505" name="RNA polymerase II transcribes snRNA genes"/>
            <pathway-xref db="Reactome" id="R-MMU-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DRE-5607761" name="Dectin-1 mediated noncanonical NF-kB signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-5687128" name="MAPK6/MAPK4 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-5632684" name="Hedgehog 'on' state"/>
            <pathway-xref db="Reactome" id="R-SPO-6807505" name="RNA polymerase II transcribes snRNA genes"/>
            <pathway-xref db="Reactome" id="R-MMU-349425" name="Autodegradation of the E3 ubiquitin ligase COP1"/>
            <pathway-xref db="Reactome" id="R-DME-187577" name="SCF(Skp2)-mediated degradation of p27/p21"/>
            <pathway-xref db="Reactome" id="R-MMU-2514859" name="Inactivation, recovery and regulation of the phototransduction cascade"/>
            <pathway-xref db="Reactome" id="R-DRE-9617828" name="FOXO-mediated transcription of cell cycle genes"/>
            <pathway-xref db="MetaCyc" id="PWY-7599" name="anditomin biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-6679" name="jadomycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-HSA-198693" name="AKT phosphorylates targets in the nucleus"/>
            <pathway-xref db="Reactome" id="R-MMU-9020702" name="Interleukin-1 signaling"/>
            <pathway-xref db="Reactome" id="R-CEL-9013420" name="RHOU GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-6783310" name="Fanconi Anemia Pathway"/>
            <pathway-xref db="Reactome" id="R-SPO-77075" name="RNA Pol II CTD phosphorylation and interaction with CE"/>
            <pathway-xref db="MetaCyc" id="PWY-5113" name="UDP-D-apiose biosynthesis (from UDP-D-glucuronate)"/>
            <pathway-xref db="Reactome" id="R-MMU-9614399" name="Regulation of localization of FOXO transcription factors"/>
            <pathway-xref db="Reactome" id="R-HSA-8952158" name="RUNX3 regulates BCL2L11 (BIM) transcription"/>
            <pathway-xref db="MetaCyc" id="PWY-7168" name="flavonol acylglucoside biosynthesis I - kaempferol derivatives"/>
            <pathway-xref db="Reactome" id="R-SPO-69166" name="Removal of the Flap Intermediate"/>
            <pathway-xref db="Reactome" id="R-XTR-4641258" name="Degradation of DVL"/>
            <pathway-xref db="Reactome" id="R-HSA-2559580" name="Oxidative Stress Induced Senescence"/>
            <pathway-xref db="MetaCyc" id="PWY-7127" name="CDP-D-mannitol biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5959" name="aflatoxins B1 and G1 biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5307" name="gentiodelphin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8036" name="chaxamycin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7743" name="dimycocerosyl triglycosyl phenolphthiocerol biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-167246" name="Tat-mediated elongation of the HIV-1 transcript"/>
            <pathway-xref db="MetaCyc" id="PWY-6409" name="pyoverdine I biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-3232118" name="SUMOylation of transcription factors"/>
            <pathway-xref db="Reactome" id="R-CEL-6781823" name="Formation of TC-NER Pre-Incision Complex"/>
            <pathway-xref db="Reactome" id="R-MMU-9013026" name="RHOB GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DDI-69601" name="Ubiquitin Mediated Degradation of Phosphorylated Cdc25A"/>
            <pathway-xref db="Reactome" id="R-HSA-1169091" name="Activation of NF-kappaB in B cells"/>
            <pathway-xref db="MetaCyc" id="PWY-7160" name="polymethylated myricetin biosynthesis (tomato)"/>
            <pathway-xref db="MetaCyc" id="PWY-1186" name="L-homomethionine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6971" name="oleandomycin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6340" name="5,5'-dehydrodivanillate degradation"/>
            <pathway-xref db="Reactome" id="R-DDI-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-9705462" name="Inactivation of CSF3 (G-CSF) signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-76066" name="RNA Polymerase III Transcription Initiation From Type 2 Promoter"/>
            <pathway-xref db="Reactome" id="R-SPO-350562" name="Regulation of ornithine decarboxylase (ODC)"/>
            <pathway-xref db="Reactome" id="R-HSA-5696400" name="Dual Incision in GG-NER"/>
            <pathway-xref db="Reactome" id="R-MMU-3108214" name="SUMOylation of DNA damage response and repair proteins"/>
            <pathway-xref db="Reactome" id="R-CEL-2470946" name="Cohesin Loading onto Chromatin"/>
            <pathway-xref db="Reactome" id="R-DRE-8939236" name="RUNX1 regulates transcription of genes involved in differentiation of HSCs"/>
            <pathway-xref db="Reactome" id="R-HSA-9633012" name="Response of EIF2AK4 (GCN2) to amino acid deficiency"/>
            <pathway-xref db="Reactome" id="R-MMU-9696264" name="RND3 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-5665" name="vanillin biosynthesis I"/>
            <pathway-xref db="Reactome" id="R-CEL-2468052" name="Establishment of Sister Chromatid Cohesion"/>
            <pathway-xref db="Reactome" id="R-MMU-9696270" name="RND2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-5607761" name="Dectin-1 mediated noncanonical NF-kB signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-112382" name="Formation of RNA Pol II elongation complex"/>
            <pathway-xref db="Reactome" id="R-RNO-9617828" name="FOXO-mediated transcription of cell cycle genes"/>
            <pathway-xref db="Reactome" id="R-SPO-5358565" name="Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)"/>
            <pathway-xref db="Reactome" id="R-HSA-9696273" name="RND1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-CEL-68911" name="G2 Phase"/>
            <pathway-xref db="Reactome" id="R-DDI-176407" name="Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase"/>
            <pathway-xref db="MetaCyc" id="PWY-5470" name="palmatine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-180534" name="Vpu mediated degradation of CD4"/>
            <pathway-xref db="Reactome" id="R-HSA-2028269" name="Signaling by Hippo"/>
            <pathway-xref db="Reactome" id="R-HSA-167162" name="RNA Polymerase II HIV Promoter Escape"/>
            <pathway-xref db="MetaCyc" id="PWY-6456" name="serinol biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-211163" name="AKT-mediated inactivation of FOXO1A"/>
            <pathway-xref db="MetaCyc" id="PWY-5873" name="ubiquinol-7 biosynthesis (late decarboxylation)"/>
            <pathway-xref db="Reactome" id="R-SSC-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-MMU-5684264" name="MAP3K8 (TPL2)-dependent MAPK1/3 activation"/>
            <pathway-xref db="Reactome" id="R-HSA-5678895" name="Defective CFTR causes cystic fibrosis"/>
            <pathway-xref db="MetaCyc" id="PWY-5048" name="rosmarinic acid biosynthesis I"/>
            <pathway-xref db="Reactome" id="R-HSA-6804758" name="Regulation of TP53 Activity through Acetylation"/>
            <pathway-xref db="Reactome" id="R-DME-975956" name="Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"/>
            <pathway-xref db="Reactome" id="R-DME-174178" name="APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1"/>
            <pathway-xref db="MetaCyc" id="PWY-8055" name="palmitoyl ethanolamide biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SCE-174113" name="SCF-beta-TrCP mediated degradation of Emi1"/>
            <pathway-xref db="Reactome" id="R-HSA-5651801" name="PCNA-Dependent Long Patch Base Excision Repair"/>
            <pathway-xref db="Reactome" id="R-HSA-1660516" name="Synthesis of PIPs at the early endosome membrane"/>
            <pathway-xref db="Reactome" id="R-MMU-5693607" name="Processing of DNA double-strand break ends"/>
            <pathway-xref db="Reactome" id="R-HSA-9615017" name="FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes"/>
            <pathway-xref db="Reactome" id="R-CEL-2514859" name="Inactivation, recovery and regulation of the phototransduction cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-9673768" name="Signaling by membrane-tethered fusions of PDGFRA or PDGFRB"/>
            <pathway-xref db="Reactome" id="R-RNO-77042" name="Formation of editosomes by ADAR proteins"/>
            <pathway-xref db="MetaCyc" id="PWY-7450" name="anthocyanidin modification (Arabidopsis)"/>
            <pathway-xref db="Reactome" id="R-MMU-176409" name="APC/C:Cdc20 mediated degradation of mitotic proteins"/>
            <pathway-xref db="MetaCyc" id="PWY-7354" name="aclacinomycin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7517" name="brassicicene C biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SPO-3371568" name="Attenuation phase"/>
            <pathway-xref db="Reactome" id="R-DME-2028269" name="Signaling by Hippo"/>
            <pathway-xref db="Reactome" id="R-RNO-6804116" name="TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest"/>
            <pathway-xref db="Reactome" id="R-MMU-392517" name="Rap1 signalling"/>
            <pathway-xref db="Reactome" id="R-DRE-5668541" name="TNFR2 non-canonical NF-kB pathway"/>
            <pathway-xref db="Reactome" id="R-HSA-72163" name="mRNA Splicing - Major Pathway"/>
            <pathway-xref db="Reactome" id="R-SSC-1169408" name="ISG15 antiviral mechanism"/>
            <pathway-xref db="MetaCyc" id="PWY-5268" name="salvianin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-4061" name="glutathione-mediated detoxification I"/>
            <pathway-xref db="Reactome" id="R-CEL-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-9031628" name="NGF-stimulated transcription"/>
            <pathway-xref db="Reactome" id="R-DME-1236978" name="Cross-presentation of soluble exogenous antigens (endosomes)"/>
            <pathway-xref db="MetaCyc" id="PWY-8037" name="saliniketal A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-1810476" name="RIP-mediated NFkB activation via ZBP1"/>
            <pathway-xref db="MetaCyc" id="PWY-5929" name="puromycin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-601" name="glucosinolate biosynthesis from tryptophan"/>
            <pathway-xref db="Reactome" id="R-SCE-72706" name="GTP hydrolysis and joining of the 60S ribosomal subunit"/>
            <pathway-xref db="Reactome" id="R-MMU-1912408" name="Pre-NOTCH Transcription and Translation"/>
            <pathway-xref db="Reactome" id="R-DME-209360" name="Ubiquitination and proteolysis of phosphorylated CI"/>
            <pathway-xref db="Reactome" id="R-DME-1799339" name="SRP-dependent cotranslational protein targeting to membrane"/>
            <pathway-xref db="MetaCyc" id="PWY-7656" name="Spodoptera littoralis pheromone biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-3371571" name="HSF1-dependent transactivation"/>
            <pathway-xref db="MetaCyc" id="PWY-6453" name="stigma estolide biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DRE-174430" name="Telomere C-strand synthesis initiation"/>
            <pathway-xref db="Reactome" id="R-CEL-72165" name="mRNA Splicing - Minor Pathway"/>
            <pathway-xref db="Reactome" id="R-MMU-72706" name="GTP hydrolysis and joining of the 60S ribosomal subunit"/>
            <pathway-xref db="MetaCyc" id="PWY-7995" name="tricin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7692" name="bikaverin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-354192" name="Integrin signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-7811" name="6-methylpretetramide biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DDI-69231" name="Cyclin D associated events in G1"/>
            <pathway-xref db="Reactome" id="R-CEL-9013149" name="RAC1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-69481" name="G2/M Checkpoints"/>
            <pathway-xref db="Reactome" id="R-HSA-2559584" name="Formation of Senescence-Associated Heterochromatin Foci (SAHF)"/>
            <pathway-xref db="Reactome" id="R-SPO-72695" name="Formation of the ternary complex, and subsequently, the 43S complex"/>
            <pathway-xref db="Reactome" id="R-DME-8854050" name="FBXL7 down-regulates AURKA during mitotic entry and in early mitosis"/>
            <pathway-xref db="Reactome" id="R-BTA-918233" name="TRAF3-dependent IRF activation pathway"/>
            <pathway-xref db="Reactome" id="R-DME-174154" name="APC/C:Cdc20 mediated degradation of Securin"/>
            <pathway-xref db="Reactome" id="R-SPO-674695" name="RNA Polymerase II Pre-transcription Events"/>
            <pathway-xref db="MetaCyc" id="PWY-6920" name="6-gingerol analog biosynthesis (engineered)"/>
            <pathway-xref db="Reactome" id="R-CEL-8953750" name="Transcriptional Regulation by E2F6"/>
            <pathway-xref db="Reactome" id="R-DRE-8939902" name="Regulation of RUNX2 expression and activity"/>
            <pathway-xref db="MetaCyc" id="PWY-7602" name="icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)"/>
            <pathway-xref db="MetaCyc" id="PWY-7988" name="baumannoferrin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8172" name="10-methylstearate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-1181150" name="Signaling by NODAL"/>
            <pathway-xref db="Reactome" id="R-DME-8941858" name="Regulation of RUNX3 expression and activity"/>
            <pathway-xref db="Reactome" id="R-SPO-156827" name="L13a-mediated translational silencing of Ceruloplasmin expression"/>
            <pathway-xref db="MetaCyc" id="PWY-7687" name="stipitatate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-2559582" name="Senescence-Associated Secretory Phenotype (SASP)"/>
            <pathway-xref db="MetaCyc" id="PWY-6379" name="alcaligin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7206" name="pyrimidine deoxyribonucleotides dephosphorylation"/>
            <pathway-xref db="Reactome" id="R-HSA-8951664" name="Neddylation"/>
            <pathway-xref db="Reactome" id="R-DME-72689" name="Formation of a pool of free 40S subunits"/>
            <pathway-xref db="Reactome" id="R-MMU-73776" name="RNA Polymerase II Promoter Escape"/>
            <pathway-xref db="Reactome" id="R-CEL-72706" name="GTP hydrolysis and joining of the 60S ribosomal subunit"/>
            <pathway-xref db="MetaCyc" id="PWY-7730" name="T-2 toxin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-2500257" name="Resolution of Sister Chromatid Cohesion"/>
            <pathway-xref db="MetaCyc" id="PWY-7799" name="Arg/N-end rule pathway (eukaryotic)"/>
            <pathway-xref db="Reactome" id="R-HSA-174411" name="Polymerase switching on the C-strand of the telomere"/>
            <pathway-xref db="Reactome" id="R-SPO-5696400" name="Dual Incision in GG-NER"/>
            <pathway-xref db="Reactome" id="R-HSA-2871837" name="FCERI mediated NF-kB activation"/>
            <pathway-xref db="Reactome" id="R-RNO-5668541" name="TNFR2 non-canonical NF-kB pathway"/>
            <pathway-xref db="Reactome" id="R-RNO-3214847" name="HATs acetylate histones"/>
            <pathway-xref db="Reactome" id="R-HSA-9646399" name="Aggrephagy"/>
            <pathway-xref db="Reactome" id="R-CEL-392517" name="Rap1 signalling"/>
            <pathway-xref db="MetaCyc" id="PWY-6930" name="phenolic malonylglucosides biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6627" name="salinosporamide A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-72086" name="mRNA Capping"/>
            <pathway-xref db="Reactome" id="R-HSA-8866654" name="E3 ubiquitin ligases ubiquitinate target proteins"/>
            <pathway-xref db="Reactome" id="R-SPO-8951664" name="Neddylation"/>
            <pathway-xref db="Reactome" id="R-MMU-9013422" name="RHOBTB1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-DRE-72706" name="GTP hydrolysis and joining of the 60S ribosomal subunit"/>
            <pathway-xref db="Reactome" id="R-CEL-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-CEL-3108214" name="SUMOylation of DNA damage response and repair proteins"/>
            <pathway-xref db="Reactome" id="R-HSA-5358565" name="Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)"/>
            <pathway-xref db="MetaCyc" id="PWY-7405" name="aurachin RE biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-176407" name="Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase"/>
            <pathway-xref db="Reactome" id="R-SCE-917729" name="Endosomal Sorting Complex Required For Transport (ESCRT)"/>
            <pathway-xref db="Reactome" id="R-RNO-5663220" name="RHO GTPases Activate Formins"/>
            <pathway-xref db="Reactome" id="R-RNO-201688" name="WNT mediated activation of DVL"/>
            <pathway-xref db="Reactome" id="R-RNO-5676590" name="NIK--&gt;noncanonical NF-kB signaling"/>
            <pathway-xref db="Reactome" id="R-SPO-176187" name="Activation of ATR in response to replication stress"/>
            <pathway-xref db="Reactome" id="R-CEL-5687128" name="MAPK6/MAPK4 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-7072" name="hopanoid biosynthesis (bacteria)"/>
            <pathway-xref db="Reactome" id="R-DME-9018519" name="Estrogen-dependent gene expression"/>
            <pathway-xref db="Reactome" id="R-SPO-3232118" name="SUMOylation of transcription factors"/>
            <pathway-xref db="Reactome" id="R-DRE-5610785" name="GLI3 is processed to GLI3R by the proteasome"/>
            <pathway-xref db="Reactome" id="R-MMU-5099900" name="WNT5A-dependent internalization of FZD4"/>
            <pathway-xref db="Reactome" id="R-HSA-2894862" name="Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants"/>
            <pathway-xref db="Reactome" id="R-DME-5358346" name="Hedgehog ligand biogenesis"/>
            <pathway-xref db="Reactome" id="R-MMU-8877330" name="RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)"/>
            <pathway-xref db="Reactome" id="R-HSA-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-XTR-9018519" name="Estrogen-dependent gene expression"/>
            <pathway-xref db="Reactome" id="R-GGA-5696394" name="DNA Damage Recognition in GG-NER"/>
            <pathway-xref db="Reactome" id="R-HSA-77075" name="RNA Pol II CTD phosphorylation and interaction with CE"/>
            <pathway-xref db="Reactome" id="R-SPO-5651801" name="PCNA-Dependent Long Patch Base Excision Repair"/>
            <pathway-xref db="Reactome" id="R-SPO-76066" name="RNA Polymerase III Transcription Initiation From Type 2 Promoter"/>
            <pathway-xref db="Reactome" id="R-CEL-9013424" name="RHOV GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-9013423" name="RAC3 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-167287" name="HIV elongation arrest and recovery"/>
            <pathway-xref db="Reactome" id="R-RNO-9706019" name="RHOBTB3 ATPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-8043" name="ophthalmate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-5689603" name="UCH proteinases"/>
            <pathway-xref db="Reactome" id="R-RNO-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-MMU-8953750" name="Transcriptional Regulation by E2F6"/>
            <pathway-xref db="Reactome" id="R-MMU-917937" name="Iron uptake and transport"/>
            <pathway-xref db="Reactome" id="R-MMU-9013420" name="RHOU GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-9013149" name="RAC1 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-7984" name="acinetobactin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-112126" name="ALKBH3 mediated reversal of alkylation damage"/>
            <pathway-xref db="Reactome" id="R-MMU-72165" name="mRNA Splicing - Minor Pathway"/>
          </entry>
          <signature-library-release library="SUPERFAMILY" version="1.75"/>
        </signature>
        <model-ac>0048143</model-ac>
        <locations>
          <superfamilyhmmer3-location hmm-length="138" start="307" end="417">
            <location-fragments>
              <superfamilyhmmer3-location-fragment start="307" end="417" dc-status="CONTINUOUS"/>
            </location-fragments>
          </superfamilyhmmer3-location>
        </locations>
      </superfamilyhmmer3-match>
    </matches>
  </protein>
  <protein>
    <sequence md5="3cc950ae202f8a5d0fae5da4a434eef0">MAKLWLILGICLAIFGTFGEQVQALRNVRDIEHQSALGDLGFDQQRKDEEDHDYEEVMDDYELQDSFSNTSLVYFNASDYVNGSMPANVTRHHGFLHGFVESLSVILVSEIGDKTFFIAAIMAMTSNKLIVFLGAISALALMTVLSAVLGWVVTSFIPRKYTYYTCTVIMFLFGLKMLYEAWTMKPDEAQELQHEVEEELARRGSIASNSSRAREQTPEDEDQDPEGQELQEVRSEPGFDDDTEGDDASTAQSPKPKKRVQIQEKGLFGKKCYKIFKLFLNCFTMTFLAEWGDRSQLATIVLASINDVSGVCLGGVLGHTFCTGLAVIAGALIAKKISVRVVTLIGALVFLGFAIASLFFDPEEEEMIKIDF</sequence>
    <xref id="TCALIF_00210-PA" name="TCALIF_00210-PA protein Name:&quot;Similar to TMEM165 Transmembrane protein 165 (Homo sapiens)&quot; AED:0.05 eAED:0.05 QI:463|1|1|1|1|1|3|441|372"/>
    <matches>
      <hmmer3-match evalue="1.4E-40" score="137.4">
        <signature ac="PF01169" desc="Uncharacterized protein family UPF0016" name="UPF0016">
          <entry ac="IPR001727" desc="Gdt1 family" name="Gdt1" type="FAMILY"/>
          <signature-library-release library="PFAM" version="34.0"/>
        </signature>
        <model-ac>PF01169</model-ac>
        <locations>
          <hmmer3-location env-end="174" env-start="100" post-processed="true" score="72.9" evalue="1.9E-20" hmm-start="2" hmm-end="75" hmm-length="75" hmm-bounds="C_TERMINAL_COMPLETE" start="101" end="174">
            <location-fragments>
              <hmmer3-location-fragment start="101" end="174" dc-status="CONTINUOUS"/>
            </location-fragments>
          </hmmer3-location>
          <hmmer3-location env-end="354" env-start="280" post-processed="true" score="70.2" evalue="1.4E-19" hmm-start="2" hmm-end="75" hmm-length="75" hmm-bounds="C_TERMINAL_COMPLETE" start="281" end="354">
            <location-fragments>
              <hmmer3-location-fragment start="281" end="354" dc-status="CONTINUOUS"/>
            </location-fragments>
          </hmmer3-location>
        </locations>
      </hmmer3-match>
      <mobidblite-match>
        <signature ac="mobidb-lite" desc="consensus disorder prediction" name="disorder_prediction">
          <signature-library-release library="MOBIDB_LITE" version="2.0"/>
        </signature>
        <model-ac>mobidb-lite</model-ac>
        <locations>
          <mobidblite-location sequence-feature="" start="204" end="256">
            <location-fragments>
              <mobidblite-location-fragment start="204" end="256" dc-status="CONTINUOUS"/>
            </location-fragments>
          </mobidblite-location>
        </locations>
      </mobidblite-match>
      <panther-match evalue="9.0E-84" familyName="TRANSMEMBRANE PROTEIN 165" score="292.3">
        <signature ac="PTHR12608:SF1" name="TRANSMEMBRANE PROTEIN 165">
          <signature-library-release library="PANTHER" version="15.0"/>
        </signature>
        <model-ac>PTHR12608:SF1</model-ac>
        <locations>
          <panther-location env-start="82" env-end="363" hmm-start="10" hmm-end="237" hmm-length="238" hmm-bounds="INCOMPLETE" start="90" end="362">
            <location-fragments>
              <panther-location-fragment start="90" end="362" dc-status="CONTINUOUS"/>
            </location-fragments>
          </panther-location>
        </locations>
      </panther-match>
      <panther-match evalue="9.0E-84" familyName="TRANSMEMBRANE PROTEIN 165" score="292.3">
        <signature ac="PTHR12608" name="TRANSMEMBRANE PROTEIN HTP-1 RELATED">
          <entry ac="IPR001727" desc="Gdt1 family" name="Gdt1" type="FAMILY"/>
          <signature-library-release library="PANTHER" version="15.0"/>
        </signature>
        <model-ac>PTHR12608</model-ac>
        <locations>
          <panther-location env-start="82" env-end="363" hmm-start="10" hmm-end="237" hmm-length="238" hmm-bounds="INCOMPLETE" start="90" end="362">
            <location-fragments>
              <panther-location-fragment start="90" end="362" dc-status="CONTINUOUS"/>
            </location-fragments>
          </panther-location>
        </locations>
      </panther-match>
      <patternscan-match>
        <signature ac="PS01214" desc="Uncharacterized protein family UPF0016 signature." name="UPF0016">
          <entry ac="IPR001727" desc="Gdt1 family" name="Gdt1" type="FAMILY"/>
          <signature-library-release library="PROSITE_PATTERNS" version="2021_01"/>
        </signature>
        <model-ac>PS01214</model-ac>
        <locations>
          <patternscan-location level="STRONG" start="110" end="119">
            <location-fragments>
              <patternscan-location-fragment start="110" end="119" dc-status="CONTINUOUS"/>
            </location-fragments>
            <alignment>EIGDKTFFIA</alignment>
          </patternscan-location>
        </locations>
      </patternscan-match>
    </matches>
  </protein>
  <protein>
    <sequence md5="49c845de0cf0fcbae606fadb6d0c2dad">MTCSDVGTLWPLPTNLEYLSKALVTFDQVEDISIATCDCDAITEGLVNTFFNDVFLGYLKAMRATDPDIPTGPFTQDTFQVEITILVENPQESLTLRTDESYSLSIISDDLNSKKLSVGIRASTYFGARHAMETLSQLISWNNQKNTFQIHDQVLITDAPYFPHRGISVDTARQFIPIQYLKKVIDGMSFNKLNTFHWHLSDSQSFPVELPSFPQLAQYGAYYENEVYSAEDILDLVEYAMLRGIRLVPELDGPRHAANGWQFGEIEGLGTLAFCINDDELRCRGGVCGLLNPINPNLYIVLEGIFRDLRHLIPSDQFHLGADEVVFHCWNKSMEIQNWMFDQGMSGTKDDFYALWHLYQTNTLETLIRANDGQRIKATVWTSSLTQRDNFDQVLPVEDYIIQIWTNHDEPTLPNLIGQGYEVILSHEDVYYLGCGQGSWGDKAPAHCDPFKQWRDIYDFDPLDNYLAFEGSEIDRSDQILGAELGMWMEQTYGPTLEAQIFPRSAAFAERMWTKPNLNWTQAEIRFIHQRQRIVERGVIAESVQMYWCHQNEGRCRVFGDPSVPEP</sequence>
    <xref id="TCALIF_00287-PA" name="TCALIF_00287-PA protein Name:&quot;Similar to Chitooligosaccharidolytic beta-N-acetylglucosaminidase (Bombyx mori)&quot; AED:0.04 eAED:0.04 QI:0|-1|0|1|-1|1|1|0|567"/>
    <matches>
      <fingerprints-match evalue="4.4E-47" graphscan="IIIIiIiI">
        <signature ac="PR00738" desc="Glycosyl hydrolase family 20 signature" name="GLHYDRLASE20">
          <entry ac="IPR025705" desc="Beta-hexosaminidase" name="Beta_hexosaminidase_sua/sub" type="FAMILY">
            <go-xref category="MOLECULAR_FUNCTION" db="GO" id="GO:0004563" name="beta-N-acetylhexosaminidase activity"/>
            <go-xref category="BIOLOGICAL_PROCESS" db="GO" id="GO:0005975" name="carbohydrate metabolic process"/>
            <pathway-xref db="Reactome" id="R-BTA-2160916" name="Hyaluronan uptake and degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-2024101" name="CS/DS degradation"/>
            <pathway-xref db="Reactome" id="R-DME-2024101" name="CS/DS degradation"/>
            <pathway-xref db="Reactome" id="R-BTA-2022857" name="Keratan sulfate degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-2160916" name="Hyaluronan uptake and degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7883" name="anhydromuropeptides recycling II"/>
            <pathway-xref db="Reactome" id="R-HSA-2022857" name="Keratan sulfate degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-2024101" name="CS/DS degradation"/>
            <pathway-xref db="Reactome" id="R-CEL-2024101" name="CS/DS degradation"/>
            <pathway-xref db="Reactome" id="R-RNO-2160916" name="Hyaluronan uptake and degradation"/>
            <pathway-xref db="Reactome" id="R-BTA-2024101" name="CS/DS degradation"/>
            <pathway-xref db="Reactome" id="R-DDI-2024101" name="CS/DS degradation"/>
            <pathway-xref db="Reactome" id="R-DDI-2022857" name="Keratan sulfate degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-3656234" name="Defective HEXA causes GM2G1"/>
            <pathway-xref db="Reactome" id="R-DME-2022857" name="Keratan sulfate degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-3656248" name="Defective HEXB causes GM2G2"/>
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            <pathway-xref db="MetaCyc" id="PWY-7212" name="baicalein metabolism"/>
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            <pathway-xref db="MetaCyc" id="PWY-4421" name="curcumin glucoside biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-7093" name="vicianin bioactivation"/>
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            <pathway-xref db="Reactome" id="R-BTA-2022857" name="Keratan sulfate degradation"/>
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            <pathway-xref db="MetaCyc" id="PWY-1961" name="indole-3-acetate inactivation I"/>
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            <pathway-xref db="MetaCyc" id="PWY-2881" name="cytokinins 7-N-glucoside biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-DME-6798695" name="Neutrophil degranulation"/>
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            <pathway-xref db="MetaCyc" id="PWY-5793" name="maysin biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-2902" name="cytokinin-O-glucosides biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-7743" name="dimycocerosyl triglycosyl phenolphthiocerol biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-8237" name="Escherichia coli serotype O:1B/Salmonella enterica serotype O:42 O antigen biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-7849" name="urate conversion to allantoin III"/>
            <pathway-xref db="MetaCyc" id="PWY-5379" name="B series fagopyritols biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-7037" name="protein O-glycosylation (Neisseria)"/>
            <pathway-xref db="MetaCyc" id="PWY-2343" name="daidzein conjugates interconversion"/>
            <pathway-xref db="MetaCyc" id="PWY-6971" name="oleandomycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-8957275" name="Post-translational protein phosphorylation"/>
            <pathway-xref db="Reactome" id="R-RNO-210991" name="Basigin interactions"/>
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            <pathway-xref db="Reactome" id="R-MMU-2024096" name="HS-GAG degradation"/>
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            <pathway-xref db="Reactome" id="R-RNO-5654219" name="Phospholipase C-mediated cascade: FGFR1"/>
            <pathway-xref db="MetaCyc" id="PWY-6735" name="starch degradation IV"/>
            <pathway-xref db="MetaCyc" id="PWY-7697" name="geranyl beta-primeveroside biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7740" name="beta-D-mannosyl phosphomycoketide biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-5654228" name="Phospholipase C-mediated cascade, FGFR4"/>
            <pathway-xref db="Reactome" id="R-HSA-2160916" name="Hyaluronan uptake and degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-8233" name="Escherichia coli serotype O:169 O antigen biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8217" name="Escherichia coli serotype O:55/Salmonella enterica serotype O:50 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-189085" name="Digestion of dietary carbohydrate"/>
            <pathway-xref db="MetaCyc" id="PWY-7913" name="firefly bioluminescence"/>
            <pathway-xref db="MetaCyc" id="PWY-7473" name="avenacin A-1 biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6815" name="porphyran degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-8206" name="Salmonella enterica serotype O:18 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-109704" name="PI3K Cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-5654228" name="Phospholipase C-mediated cascade, FGFR4"/>
            <pathway-xref db="Reactome" id="R-HSA-2024096" name="HS-GAG degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-5654719" name="SHC-mediated cascade:FGFR4"/>
            <pathway-xref db="MetaCyc" id="PWY-7919" name="protein N-glycosylation processing phase (plants and animals)"/>
            <pathway-xref db="MetaCyc" id="PWY-7192" name="quercetin diglycoside biosynthesis (pollen-specific)"/>
            <pathway-xref db="MetaCyc" id="PWY-6762" name="salicylate glucosides biosynthesis IV"/>
            <pathway-xref db="MetaCyc" id="PWY-7885" name="phosphatidylinositol mannoside biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7647" name="ulvan degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-6190" name="2,4-dichlorotoluene degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7897" name="flavonoid di-C-glucosylation"/>
            <pathway-xref db="MetaCyc" id="PWY-7475" name="des-methyl avenacin A-1 biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6623" name="salicylate glucosides biosynthesis II"/>
            <pathway-xref db="MetaCyc" id="PWY-7437" name="protein O-[N-acetyl]-glucosylation"/>
            <pathway-xref db="MetaCyc" id="PWY-6724" name="starch degradation II"/>
            <pathway-xref db="Reactome" id="R-RNO-5654689" name="PI-3K cascade:FGFR1"/>
            <pathway-xref db="Reactome" id="R-CEL-975578" name="Reactions specific to the complex N-glycan synthesis pathway"/>
            <pathway-xref db="Reactome" id="R-RNO-6811558" name="PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-7570" name="blasticidin S biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7092" name="neolinustatin bioactivation"/>
            <pathway-xref db="MetaCyc" id="PWY-2021" name="indole-3-acetate inactivation IV"/>
            <pathway-xref db="MetaCyc" id="PWY-6855" name="chitin degradation I (archaea)"/>
            <pathway-xref db="Reactome" id="R-HSA-964739" name="N-glycan trimming and elongation in the cis-Golgi"/>
            <pathway-xref db="Reactome" id="R-RNO-8957275" name="Post-translational protein phosphorylation"/>
            <pathway-xref db="MetaCyc" id="PWY-5975" name="furaneol and mesifurane biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7450" name="anthocyanidin modification (Arabidopsis)"/>
            <pathway-xref db="Reactome" id="R-CFA-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="MetaCyc" id="PWY-7045" name="mithramycin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8122" name="mycofactocin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5926" name="afrormosin conjugates interconversion"/>
            <pathway-xref db="MetaCyc" id="PWY-8253" name="Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7145" name="genistin gentiobioside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-BTA-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="MetaCyc" id="PWY-6015" name="vitexin and derivatives biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5286" name="anthocyanidin sophoroside metabolism"/>
            <pathway-xref db="MetaCyc" id="PWY-7921" name="protein O-mannosylation I (yeast)"/>
            <pathway-xref db="Reactome" id="R-RNO-114608" name="Platelet degranulation"/>
            <pathway-xref db="MetaCyc" id="PWY-8205" name="Escherichia coli serotype O:77/Salmonella enterica serotype O:6,14 O antigen biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7530" name="Escherichia coli serotype O:104 O antigen biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7491" name="podophyllotoxin glucosides metabolism"/>
            <pathway-xref db="MetaCyc" id="PWY-5268" name="salvianin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6624" name="salicylate glucosides biosynthesis III"/>
            <pathway-xref db="Reactome" id="R-MMU-4085001" name="Sialic acid metabolism"/>
            <pathway-xref db="MetaCyc" id="PWY-7463" name="N-methylanthraniloyl-beta-D-glucopyranose biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5272" name="abscisic acid degradation by glucosylation"/>
            <pathway-xref db="MetaCyc" id="PWY-7166" name="kaempferide triglycoside biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7056" name="daphnin interconversion"/>
            <pathway-xref db="MetaCyc" id="PWY-7658" name="protein N-glycosylation (Methanococcus voltae)"/>
            <pathway-xref db="Reactome" id="R-BTA-975578" name="Reactions specific to the complex N-glycan synthesis pathway"/>
            <pathway-xref db="Reactome" id="R-HSA-109704" name="PI3K Cascade"/>
            <pathway-xref db="Reactome" id="R-MMU-70221" name="Glycogen breakdown (glycogenolysis)"/>
            <pathway-xref db="Reactome" id="R-HSA-8957275" name="Post-translational protein phosphorylation"/>
            <pathway-xref db="Reactome" id="R-HSA-975578" name="Reactions specific to the complex N-glycan synthesis pathway"/>
            <pathway-xref db="MetaCyc" id="PWY-8234" name="Escherichia coli serotype O:183/Shigella boydii serotype O:10 O antigen biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-1921" name="indole-3-acetate activation II"/>
            <pathway-xref db="MetaCyc" id="PWY-7186" name="superpathway of scopolin and esculin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5691" name="urate conversion to allantoin I"/>
            <pathway-xref db="Reactome" id="R-MMU-8957275" name="Post-translational protein phosphorylation"/>
            <pathway-xref db="MetaCyc" id="PWY-4441" name="DIMBOA-glucoside activation"/>
            <pathway-xref db="Reactome" id="R-SSC-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-CEL-381426" name="Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"/>
            <pathway-xref db="MetaCyc" id="PWY-116" name="coniferin metabolism"/>
            <pathway-xref db="MetaCyc" id="PWY-7769" name="phosalacine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8220" name="Escherichia coli serotype O:117 O antigen biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7252" name="luteolinidin 5-O-glucoside biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7058" name="esculetin modification"/>
            <pathway-xref db="MetaCyc" id="PWY-7445" name="luteolin triglucuronide degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-5267" name="glucosinolate activation"/>
            <pathway-xref db="Reactome" id="R-HSA-4085001" name="Sialic acid metabolism"/>
            <pathway-xref db="Reactome" id="R-RNO-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="MetaCyc" id="PWY-6906" name="chitin derivatives degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7074" name="phenylethanol glycoconjugate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6784" name="cellulose and hemicellulose degradation (cellulolosome)"/>
            <pathway-xref db="Reactome" id="R-HSA-189085" name="Digestion of dietary carbohydrate"/>
            <pathway-xref db="MetaCyc" id="PWY-1981" name="indole-3-acetate inactivation III"/>
            <pathway-xref db="MetaCyc" id="PWY-8058" name="2-deoxy-D-ribose degradation II"/>
            <pathway-xref db="MetaCyc" id="PWY-7730" name="T-2 toxin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8204" name="Salmonella enterica serotype O:54 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-190374" name="FGFR1c and Klotho ligand binding and activation"/>
            <pathway-xref db="Reactome" id="R-HSA-5654693" name="FRS-mediated FGFR1 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-3121" name="linamarin degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-5338" name="galactosylcyclitol biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-5654693" name="FRS-mediated FGFR1 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-6279" name="myxol-2' fucoside biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6051" name="2,4,6-trinitrotoluene degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7213" name="wogonin metabolism"/>
            <pathway-xref db="MetaCyc" id="PWY-7940" name="lauryl-hydroxychlorobactene glucoside biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6239" name="luteolin glycosides biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-CEL-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="MetaCyc" id="PWY-6310" name="aloesone biosynthesis II"/>
            <pathway-xref db="MetaCyc" id="PWY-5672" name="ginsenosides biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7139" name="sesaminol glucoside biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7191" name="kaempferol diglycoside biosynthesis (pollen-specific)"/>
            <pathway-xref db="MetaCyc" id="PWY-6657" name="polyhydroxydecanoate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6024" name="isovitexin glycosides biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7464" name="cyanidin 3,7-diglucoside polyacylation biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8242" name="Escherichia coli serotype O:51/Salmonella enterica serotype O:57 O antigen biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5666" name="alpha-solanine/alpha-chaconine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-842" name="starch degradation I"/>
            <pathway-xref db="Reactome" id="R-MMU-210991" name="Basigin interactions"/>
            <pathway-xref db="Reactome" id="R-SCE-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="MetaCyc" id="PWY-6763" name="salicortin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-BTA-70221" name="Glycogen breakdown (glycogenolysis)"/>
            <pathway-xref db="MetaCyc" id="PWY-6546" name="brassinosteroids inactivation"/>
            <pathway-xref db="MetaCyc" id="PWY-2901" name="cytokinins 9-N-glucoside biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5936" name="xyloglucan biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6002" name="lotaustralin degradation"/>
            <pathway-xref db="Reactome" id="R-DDI-2022857" name="Keratan sulfate degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7838" name="globo-series glycosphingolipids biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7633" name="calycosin 7-O-glucoside biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6346" name="staurosporine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7129" name="quercetin glucoside biosynthesis (Allium)"/>
            <pathway-xref db="MetaCyc" id="PWY-5292" name="vindoline, vindorosine and vinblastine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-381426" name="Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"/>
            <pathway-xref db="Reactome" id="R-RNO-352230" name="Amino acid transport across the plasma membrane"/>
            <pathway-xref db="MetaCyc" id="PWY-7712" name="deoxynivalenol biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5301" name="ajmaline and sarpagine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6972" name="oleandomycin activation/inactivation"/>
            <pathway-xref db="MetaCyc" id="PWY-7367" name="phosphatidylcholine resynthesis via glycerophosphocholine"/>
            <pathway-xref db="MetaCyc" id="PWY-8039" name="mitomycin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5321" name="quercetin glycoside biosynthesis (Arabidopsis)"/>
            <pathway-xref db="MetaCyc" id="PWY-8235" name="Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis"/>
          </entry>
          <signature-library-release library="SUPERFAMILY" version="1.75"/>
        </signature>
        <model-ac>0048920</model-ac>
        <locations>
          <superfamilyhmmer3-location hmm-length="443" start="162" end="524">
            <location-fragments>
              <superfamilyhmmer3-location-fragment start="162" end="524" dc-status="CONTINUOUS"/>
            </location-fragments>
          </superfamilyhmmer3-location>
        </locations>
      </superfamilyhmmer3-match>
    </matches>
  </protein>
  <protein>
    <sequence md5="0b34995556d763beabccf9e33e56b66f">MSFNLVSRATEGDFETRRTRFNLSEVNTVGELVQKAATVTQIRPESIQLLFRGILLKSPEQTLAQIGLRANATIYILKAPVVSSVEPMGPKDLSDEEMKRFFVAFGMAIRNPALNVALKRLTQRENLESLAGACPGLAQDPMALAFLNKPEMLMMLLKPEILQRVAQEHPSLHEAMVNLAAAVHEERPSKSSQLDGESLPTPFSYHLDDMSDVDDDEDMEEDGFGSDLQRNRSFSAITPNQLAAAIAAAQNSAGASTGNTTAGALGGLLPNSLGVESTPGSSTGSSMPSSSRPTPSSPAITSDSFRQALEQAMAASGQVLSQNQSSSSLNAASEPMEASDYGPEQIEKDVATMRELGIVDEGLAQKALKLMGGDLQAAIDLVFSGWLGEDDAAS</sequence>
    <xref id="TCALIF_00811-PA" name="TCALIF_00811-PA protein Name:&quot;Similar to UBL7 Ubiquitin-like protein 7 (Bos taurus)&quot; AED:0.03 eAED:0.03 QI:166|1|1|1|1|1|2|68|394"/>
    <matches>
      <hmmer2-match evalue="1.4E-4" score="31.2">
        <signature ac="SM00165" name="uba_6">
          <entry ac="IPR015940" desc="Ubiquitin-associated domain" name="UBA" type="DOMAIN">
            <pathway-xref db="Reactome" id="R-MMU-5696394" name="DNA Damage Recognition in GG-NER"/>
            <pathway-xref db="Reactome" id="R-HSA-5673000" name="RAF activation"/>
            <pathway-xref db="Reactome" id="R-MMU-9664873" name="Pexophagy"/>
            <pathway-xref db="Reactome" id="R-HSA-5357956" name="TNFR1-induced NFkappaB signaling pathway"/>
            <pathway-xref db="Reactome" id="R-SCE-532668" name="N-glycan trimming in the ER and Calnexin/Calreticulin cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-9610379" name="HCMV Late Events"/>
            <pathway-xref db="Reactome" id="R-MMU-5673000" name="RAF activation"/>
            <pathway-xref db="Reactome" id="R-XTR-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-DDI-8948751" name="Regulation of PTEN stability and activity"/>
            <pathway-xref db="Reactome" id="R-HSA-9018519" name="Estrogen-dependent gene expression"/>
            <pathway-xref db="Reactome" id="R-HSA-4086398" name="Ca2+ pathway"/>
            <pathway-xref db="Reactome" id="R-HSA-1059683" name="Interleukin-6 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9029569" name="NR1H3 &amp; NR1H2 regulate gene expression linked to cholesterol transport and efflux"/>
            <pathway-xref db="Reactome" id="R-MMU-209560" name="NF-kB is activated and signals survival"/>
            <pathway-xref db="Reactome" id="R-MMU-5620912" name="Anchoring of the basal body to the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-DRE-917729" name="Endosomal Sorting Complex Required For Transport (ESCRT)"/>
            <pathway-xref db="Reactome" id="R-HSA-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-HSA-9664873" name="Pexophagy"/>
            <pathway-xref db="Reactome" id="R-MMU-1059683" name="Interleukin-6 signaling"/>
            <pathway-xref db="Reactome" id="R-CEL-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-HSA-5620912" name="Anchoring of the basal body to the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-BTA-5689877" name="Josephin domain DUBs"/>
            <pathway-xref db="Reactome" id="R-HSA-209543" name="p75NTR recruits signalling complexes"/>
            <pathway-xref db="Reactome" id="R-RNO-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-532668" name="N-glycan trimming in the ER and Calnexin/Calreticulin cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-5674135" name="MAP2K and MAPK activation"/>
            <pathway-xref db="Reactome" id="R-RNO-5675221" name="Negative regulation of MAPK pathway"/>
            <pathway-xref db="Reactome" id="R-HSA-6807004" name="Negative regulation of MET activity"/>
            <pathway-xref db="Reactome" id="R-BTA-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-5654733" name="Negative regulation of FGFR4 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-182971" name="EGFR downregulation"/>
            <pathway-xref db="Reactome" id="R-MMU-5654727" name="Negative regulation of FGFR2 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-162588" name="Budding and maturation of HIV virion"/>
            <pathway-xref db="Reactome" id="R-HSA-5675221" name="Negative regulation of MAPK pathway"/>
            <pathway-xref db="Reactome" id="R-DME-426496" name="Post-transcriptional silencing by small RNAs"/>
            <pathway-xref db="Reactome" id="R-HSA-9706377" name="FLT3 signaling by CBL mutants"/>
            <pathway-xref db="Reactome" id="R-HSA-174490" name="Membrane binding and targetting of GAG proteins"/>
            <pathway-xref db="Reactome" id="R-MMU-5357956" name="TNFR1-induced NFkappaB signaling pathway"/>
            <pathway-xref db="Reactome" id="R-SPO-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-HSA-8856828" name="Clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-HSA-9649948" name="Signaling downstream of RAS mutants"/>
            <pathway-xref db="Reactome" id="R-SPO-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-HSA-5696394" name="DNA Damage Recognition in GG-NER"/>
            <pathway-xref db="Reactome" id="R-HSA-1433559" name="Regulation of KIT signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-8981373" name="Intestinal hexose absorption"/>
            <pathway-xref db="Reactome" id="R-HSA-8853884" name="Transcriptional Regulation by VENTX"/>
            <pathway-xref db="Reactome" id="R-MMU-8849469" name="PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1"/>
            <pathway-xref db="Reactome" id="R-MMU-549127" name="Organic cation transport"/>
            <pathway-xref db="Reactome" id="R-MMU-426496" name="Post-transcriptional silencing by small RNAs"/>
            <pathway-xref db="Reactome" id="R-MMU-5696395" name="Formation of Incision Complex in GG-NER"/>
            <pathway-xref db="Reactome" id="R-HSA-9656223" name="Signaling by RAF1 mutants"/>
            <pathway-xref db="Reactome" id="R-HSA-5654726" name="Negative regulation of FGFR1 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-400253" name="Circadian Clock"/>
            <pathway-xref db="Reactome" id="R-DRE-532668" name="N-glycan trimming in the ER and Calnexin/Calreticulin cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-1433559" name="Regulation of KIT signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-5696394" name="DNA Damage Recognition in GG-NER"/>
            <pathway-xref db="Reactome" id="R-RNO-917729" name="Endosomal Sorting Complex Required For Transport (ESCRT)"/>
            <pathway-xref db="Reactome" id="R-HSA-9706369" name="Negative regulation of FLT3"/>
            <pathway-xref db="Reactome" id="R-MMU-5654732" name="Negative regulation of FGFR3 signaling"/>
            <pathway-xref db="Reactome" id="R-SPO-8856828" name="Clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-MMU-5357905" name="Regulation of TNFR1 signaling"/>
            <pathway-xref db="Reactome" id="R-SPO-5696395" name="Formation of Incision Complex in GG-NER"/>
            <pathway-xref db="Reactome" id="R-RNO-209543" name="p75NTR recruits signalling complexes"/>
            <pathway-xref db="Reactome" id="R-DRE-8948751" name="Regulation of PTEN stability and activity"/>
            <pathway-xref db="Reactome" id="R-HSA-8936459" name="RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"/>
            <pathway-xref db="Reactome" id="R-MMU-8866652" name="Synthesis of active ubiquitin: roles of E1 and E2 enzymes"/>
            <pathway-xref db="Reactome" id="R-BTA-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-MMU-9706369" name="Negative regulation of FLT3"/>
            <pathway-xref db="Reactome" id="R-MMU-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-DME-5205685" name="PINK1-PRKN Mediated Mitophagy"/>
            <pathway-xref db="Reactome" id="R-HSA-5357905" name="Regulation of TNFR1 signaling"/>
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            <pathway-xref db="Reactome" id="R-HSA-8875360" name="InlB-mediated entry of Listeria monocytogenes into host cell"/>
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        <model-ac>PF00240</model-ac>
        <locations>
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      <mobidblite-match>
        <signature ac="mobidb-lite" desc="consensus disorder prediction" name="disorder_prediction">
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        <model-ac>mobidb-lite</model-ac>
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        </locations>
      </mobidblite-match>
      <mobidblite-match>
        <signature ac="mobidb-lite" desc="consensus disorder prediction" name="disorder_prediction">
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        <model-ac>mobidb-lite</model-ac>
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      <mobidblite-match>
        <signature ac="mobidb-lite" desc="consensus disorder prediction" name="disorder_prediction">
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        <model-ac>mobidb-lite</model-ac>
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      <panther-match evalue="5.2E-41" familyName="UBIQUITIN-LIKE PROTEIN 7" score="153.0">
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      <panther-match evalue="5.2E-41" familyName="UBIQUITIN-LIKE PROTEIN 7" score="153.0">
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          </entry>
          <signature-library-release library="PROSITE_PROFILES" version="2021_01"/>
        </signature>
        <model-ac>PS50053</model-ac>
        <locations>
          <profilescan-location score="11.02845" start="3" end="77">
            <location-fragments>
              <profilescan-location-fragment start="3" end="77" dc-status="CONTINUOUS"/>
            </location-fragments>
            <alignment>FNLVSRATEGdfetRRTRFNLSEVNTVGELVQKAATVTQIRPESIQLLFRGILLKSPeQTLAQIGLRANATIYIL------</alignment>
          </profilescan-location>
        </locations>
      </profilescan-match>
      <profilescan-match>
        <signature ac="PS50030" desc="Ubiquitin-associated domain (UBA) profile." name="UBA">
          <entry ac="IPR015940" desc="Ubiquitin-associated domain" name="UBA" type="DOMAIN">
            <pathway-xref db="Reactome" id="R-MMU-5696394" name="DNA Damage Recognition in GG-NER"/>
            <pathway-xref db="Reactome" id="R-HSA-5673000" name="RAF activation"/>
            <pathway-xref db="Reactome" id="R-MMU-9664873" name="Pexophagy"/>
            <pathway-xref db="Reactome" id="R-HSA-5357956" name="TNFR1-induced NFkappaB signaling pathway"/>
            <pathway-xref db="Reactome" id="R-SCE-532668" name="N-glycan trimming in the ER and Calnexin/Calreticulin cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-9610379" name="HCMV Late Events"/>
            <pathway-xref db="Reactome" id="R-MMU-5673000" name="RAF activation"/>
            <pathway-xref db="Reactome" id="R-XTR-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-DDI-8948751" name="Regulation of PTEN stability and activity"/>
            <pathway-xref db="Reactome" id="R-HSA-9018519" name="Estrogen-dependent gene expression"/>
            <pathway-xref db="Reactome" id="R-HSA-4086398" name="Ca2+ pathway"/>
            <pathway-xref db="Reactome" id="R-HSA-1059683" name="Interleukin-6 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9029569" name="NR1H3 &amp; NR1H2 regulate gene expression linked to cholesterol transport and efflux"/>
            <pathway-xref db="Reactome" id="R-MMU-209560" name="NF-kB is activated and signals survival"/>
            <pathway-xref db="Reactome" id="R-MMU-5620912" name="Anchoring of the basal body to the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-DRE-917729" name="Endosomal Sorting Complex Required For Transport (ESCRT)"/>
            <pathway-xref db="Reactome" id="R-HSA-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-HSA-9664873" name="Pexophagy"/>
            <pathway-xref db="Reactome" id="R-MMU-1059683" name="Interleukin-6 signaling"/>
            <pathway-xref db="Reactome" id="R-CEL-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-HSA-5620912" name="Anchoring of the basal body to the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-BTA-5689877" name="Josephin domain DUBs"/>
            <pathway-xref db="Reactome" id="R-HSA-209543" name="p75NTR recruits signalling complexes"/>
            <pathway-xref db="Reactome" id="R-RNO-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-532668" name="N-glycan trimming in the ER and Calnexin/Calreticulin cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-5674135" name="MAP2K and MAPK activation"/>
            <pathway-xref db="Reactome" id="R-RNO-5675221" name="Negative regulation of MAPK pathway"/>
            <pathway-xref db="Reactome" id="R-HSA-6807004" name="Negative regulation of MET activity"/>
            <pathway-xref db="Reactome" id="R-BTA-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-5654733" name="Negative regulation of FGFR4 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-182971" name="EGFR downregulation"/>
            <pathway-xref db="Reactome" id="R-MMU-5654727" name="Negative regulation of FGFR2 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-162588" name="Budding and maturation of HIV virion"/>
            <pathway-xref db="Reactome" id="R-HSA-5675221" name="Negative regulation of MAPK pathway"/>
            <pathway-xref db="Reactome" id="R-DME-426496" name="Post-transcriptional silencing by small RNAs"/>
            <pathway-xref db="Reactome" id="R-HSA-9706377" name="FLT3 signaling by CBL mutants"/>
            <pathway-xref db="Reactome" id="R-HSA-174490" name="Membrane binding and targetting of GAG proteins"/>
            <pathway-xref db="Reactome" id="R-MMU-5357956" name="TNFR1-induced NFkappaB signaling pathway"/>
            <pathway-xref db="Reactome" id="R-SPO-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-HSA-8856828" name="Clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-HSA-9649948" name="Signaling downstream of RAS mutants"/>
            <pathway-xref db="Reactome" id="R-SPO-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-HSA-5696394" name="DNA Damage Recognition in GG-NER"/>
            <pathway-xref db="Reactome" id="R-HSA-1433559" name="Regulation of KIT signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-8981373" name="Intestinal hexose absorption"/>
            <pathway-xref db="Reactome" id="R-HSA-8853884" name="Transcriptional Regulation by VENTX"/>
            <pathway-xref db="Reactome" id="R-MMU-8849469" name="PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1"/>
            <pathway-xref db="Reactome" id="R-MMU-549127" name="Organic cation transport"/>
            <pathway-xref db="Reactome" id="R-MMU-426496" name="Post-transcriptional silencing by small RNAs"/>
            <pathway-xref db="Reactome" id="R-MMU-5696395" name="Formation of Incision Complex in GG-NER"/>
            <pathway-xref db="Reactome" id="R-HSA-9656223" name="Signaling by RAF1 mutants"/>
            <pathway-xref db="Reactome" id="R-HSA-5654726" name="Negative regulation of FGFR1 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-400253" name="Circadian Clock"/>
            <pathway-xref db="Reactome" id="R-DRE-532668" name="N-glycan trimming in the ER and Calnexin/Calreticulin cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-1433559" name="Regulation of KIT signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-5696394" name="DNA Damage Recognition in GG-NER"/>
            <pathway-xref db="Reactome" id="R-RNO-917729" name="Endosomal Sorting Complex Required For Transport (ESCRT)"/>
            <pathway-xref db="Reactome" id="R-HSA-9706369" name="Negative regulation of FLT3"/>
            <pathway-xref db="Reactome" id="R-MMU-5654732" name="Negative regulation of FGFR3 signaling"/>
            <pathway-xref db="Reactome" id="R-SPO-8856828" name="Clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-MMU-5357905" name="Regulation of TNFR1 signaling"/>
            <pathway-xref db="Reactome" id="R-SPO-5696395" name="Formation of Incision Complex in GG-NER"/>
            <pathway-xref db="Reactome" id="R-RNO-209543" name="p75NTR recruits signalling complexes"/>
            <pathway-xref db="Reactome" id="R-DRE-8948751" name="Regulation of PTEN stability and activity"/>
            <pathway-xref db="Reactome" id="R-HSA-8936459" name="RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"/>
            <pathway-xref db="Reactome" id="R-MMU-8866652" name="Synthesis of active ubiquitin: roles of E1 and E2 enzymes"/>
            <pathway-xref db="Reactome" id="R-BTA-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-MMU-9706369" name="Negative regulation of FLT3"/>
            <pathway-xref db="Reactome" id="R-MMU-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-DME-5205685" name="PINK1-PRKN Mediated Mitophagy"/>
            <pathway-xref db="Reactome" id="R-HSA-5357905" name="Regulation of TNFR1 signaling"/>
            <pathway-xref db="Reactome" id="R-DDI-5696395" name="Formation of Incision Complex in GG-NER"/>
            <pathway-xref db="Reactome" id="R-HSA-8875360" name="InlB-mediated entry of Listeria monocytogenes into host cell"/>
            <pathway-xref db="Reactome" id="R-HSA-8943723" name="Regulation of PTEN mRNA translation"/>
            <pathway-xref db="Reactome" id="R-DRE-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-HSA-532668" name="N-glycan trimming in the ER and Calnexin/Calreticulin cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-9020702" name="Interleukin-1 signaling"/>
            <pathway-xref db="Reactome" id="R-DDI-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-HSA-1912408" name="Pre-NOTCH Transcription and Translation"/>
            <pathway-xref db="Reactome" id="R-HSA-6802952" name="Signaling by BRAF and RAF fusions"/>
            <pathway-xref db="Reactome" id="R-HSA-1236382" name="Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants"/>
            <pathway-xref db="Reactome" id="R-MMU-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-RNO-5674135" name="MAP2K and MAPK activation"/>
            <pathway-xref db="Reactome" id="R-HSA-5674135" name="MAP2K and MAPK activation"/>
            <pathway-xref db="Reactome" id="R-HSA-9615710" name="Late endosomal microautophagy"/>
            <pathway-xref db="Reactome" id="R-RNO-5689877" name="Josephin domain DUBs"/>
            <pathway-xref db="Reactome" id="R-HSA-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-MMU-5654733" name="Negative regulation of FGFR4 signaling"/>
            <pathway-xref db="Reactome" id="R-DDI-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-HSA-209560" name="NF-kB is activated and signals survival"/>
            <pathway-xref db="Reactome" id="R-HSA-936440" name="Negative regulators of DDX58/IFIH1 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-5637810" name="Constitutive Signaling by EGFRvIII"/>
            <pathway-xref db="Reactome" id="R-HSA-2559580" name="Oxidative Stress Induced Senescence"/>
            <pathway-xref db="Reactome" id="R-HSA-2173789" name="TGF-beta receptor signaling activates SMADs"/>
            <pathway-xref db="Reactome" id="R-MMU-6807004" name="Negative regulation of MET activity"/>
            <pathway-xref db="Reactome" id="R-HSA-6802955" name="Paradoxical activation of RAF signaling by kinase inactive BRAF"/>
            <pathway-xref db="MetaCyc" id="PWY-6308" name="L-cysteine biosynthesis II (tRNA-dependent)"/>
            <pathway-xref db="Reactome" id="R-MMU-8856828" name="Clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-DDI-8866652" name="Synthesis of active ubiquitin: roles of E1 and E2 enzymes"/>
            <pathway-xref db="Reactome" id="R-HSA-8951664" name="Neddylation"/>
            <pathway-xref db="Reactome" id="R-HSA-549127" name="Organic cation transport"/>
            <pathway-xref db="Reactome" id="R-MMU-8948751" name="Regulation of PTEN stability and activity"/>
            <pathway-xref db="Reactome" id="R-MMU-917729" name="Endosomal Sorting Complex Required For Transport (ESCRT)"/>
            <pathway-xref db="Reactome" id="R-HSA-426496" name="Post-transcriptional silencing by small RNAs"/>
            <pathway-xref db="Reactome" id="R-MMU-1295596" name="Spry regulation of FGF signaling"/>
            <pathway-xref db="Reactome" id="R-SPO-200425" name="Carnitine metabolism"/>
            <pathway-xref db="Reactome" id="R-RNO-5696395" name="Formation of Incision Complex in GG-NER"/>
            <pathway-xref db="Reactome" id="R-HSA-1295596" name="Spry regulation of FGF signaling"/>
            <pathway-xref db="Reactome" id="R-DME-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-8948751" name="Regulation of PTEN stability and activity"/>
            <pathway-xref db="Reactome" id="R-HSA-2559585" name="Oncogene Induced Senescence"/>
            <pathway-xref db="Reactome" id="R-DDI-5673000" name="RAF activation"/>
            <pathway-xref db="Reactome" id="R-HSA-5628897" name="TP53 Regulates Metabolic Genes"/>
            <pathway-xref db="Reactome" id="R-DME-8866652" name="Synthesis of active ubiquitin: roles of E1 and E2 enzymes"/>
            <pathway-xref db="Reactome" id="R-HSA-5689877" name="Josephin domain DUBs"/>
            <pathway-xref db="Reactome" id="R-HSA-8986944" name="Transcriptional Regulation by MECP2"/>
            <pathway-xref db="Reactome" id="R-DDI-5696394" name="DNA Damage Recognition in GG-NER"/>
            <pathway-xref db="Reactome" id="R-MMU-209543" name="p75NTR recruits signalling complexes"/>
            <pathway-xref db="Reactome" id="R-DDI-5675221" name="Negative regulation of MAPK pathway"/>
            <pathway-xref db="Reactome" id="R-SPO-163680" name="AMPK inhibits chREBP transcriptional activation activity"/>
            <pathway-xref db="Reactome" id="R-HSA-6802946" name="Signaling by moderate kinase activity BRAF mutants"/>
            <pathway-xref db="Reactome" id="R-HSA-9022692" name="Regulation of MECP2 expression and activity"/>
            <pathway-xref db="Reactome" id="R-MMU-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-HSA-205043" name="NRIF signals cell death from the nucleus"/>
            <pathway-xref db="Reactome" id="R-HSA-182971" name="EGFR downregulation"/>
            <pathway-xref db="Reactome" id="R-MMU-2173789" name="TGF-beta receptor signaling activates SMADs"/>
            <pathway-xref db="Reactome" id="R-HSA-5205685" name="PINK1-PRKN Mediated Mitophagy"/>
            <pathway-xref db="Reactome" id="R-MMU-912631" name="Regulation of signaling by CBL"/>
            <pathway-xref db="Reactome" id="R-RNO-205043" name="NRIF signals cell death from the nucleus"/>
            <pathway-xref db="Reactome" id="R-HSA-6802948" name="Signaling by high-kinase activity BRAF mutants"/>
            <pathway-xref db="Reactome" id="R-SPO-8866652" name="Synthesis of active ubiquitin: roles of E1 and E2 enzymes"/>
            <pathway-xref db="Reactome" id="R-RNO-5205685" name="PINK1-PRKN Mediated Mitophagy"/>
            <pathway-xref db="MetaCyc" id="PWY-7511" name="protein ubiquitination"/>
            <pathway-xref db="Reactome" id="R-HSA-5696395" name="Formation of Incision Complex in GG-NER"/>
            <pathway-xref db="Reactome" id="R-DME-5578749" name="Transcriptional regulation by small RNAs"/>
            <pathway-xref db="MetaCyc" id="PWY-7884" name="lipoprotein posttranslational modification"/>
            <pathway-xref db="Reactome" id="R-MMU-8951664" name="Neddylation"/>
            <pathway-xref db="Reactome" id="R-SCE-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-RNO-9664873" name="Pexophagy"/>
            <pathway-xref db="Reactome" id="R-RNO-209560" name="NF-kB is activated and signals survival"/>
            <pathway-xref db="Reactome" id="R-HSA-8849469" name="PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1"/>
            <pathway-xref db="Reactome" id="R-HSA-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-5654732" name="Negative regulation of FGFR3 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-5693565" name="Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"/>
            <pathway-xref db="Reactome" id="R-HSA-912631" name="Regulation of signaling by CBL"/>
            <pathway-xref db="Reactome" id="R-HSA-917729" name="Endosomal Sorting Complex Required For Transport (ESCRT)"/>
            <pathway-xref db="Reactome" id="R-HSA-8866652" name="Synthesis of active ubiquitin: roles of E1 and E2 enzymes"/>
            <pathway-xref db="Reactome" id="R-HSA-2028269" name="Signaling by Hippo"/>
            <pathway-xref db="Reactome" id="R-HSA-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-HSA-9020702" name="Interleukin-1 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-2028269" name="Signaling by Hippo"/>
            <pathway-xref db="Reactome" id="R-RNO-5673000" name="RAF activation"/>
            <pathway-xref db="Reactome" id="R-SCE-8856828" name="Clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-HSA-5654727" name="Negative regulation of FGFR2 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-5205685" name="PINK1-PRKN Mediated Mitophagy"/>
            <pathway-xref db="Reactome" id="R-HSA-8934593" name="Regulation of RUNX1 Expression and Activity"/>
            <pathway-xref db="Reactome" id="R-SCE-5696395" name="Formation of Incision Complex in GG-NER"/>
            <pathway-xref db="Reactome" id="R-MMU-5689877" name="Josephin domain DUBs"/>
            <pathway-xref db="Reactome" id="R-MMU-5675221" name="Negative regulation of MAPK pathway"/>
            <pathway-xref db="Reactome" id="R-DDI-5674135" name="MAP2K and MAPK activation"/>
            <pathway-xref db="Reactome" id="R-RNO-9020702" name="Interleukin-1 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-SPO-1632852" name="Macroautophagy"/>
            <pathway-xref db="Reactome" id="R-HSA-5687128" name="MAPK6/MAPK4 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-8981373" name="Intestinal hexose absorption"/>
            <pathway-xref db="Reactome" id="R-HSA-8948700" name="Competing endogenous RNAs (ceRNAs) regulate PTEN translation"/>
            <pathway-xref db="Reactome" id="R-BTA-5696394" name="DNA Damage Recognition in GG-NER"/>
            <pathway-xref db="Reactome" id="R-SPO-380972" name="Energy dependent regulation of mTOR by LKB1-AMPK"/>
            <pathway-xref db="Reactome" id="R-RNO-532668" name="N-glycan trimming in the ER and Calnexin/Calreticulin cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-5654726" name="Negative regulation of FGFR1 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-205043" name="NRIF signals cell death from the nucleus"/>
            <pathway-xref db="Reactome" id="R-SPO-5628897" name="TP53 Regulates Metabolic Genes"/>
          </entry>
          <signature-library-release library="PROSITE_PROFILES" version="2021_01"/>
        </signature>
        <model-ac>PS50030</model-ac>
        <locations>
          <profilescan-location score="9.558853" start="344" end="385">
            <location-fragments>
              <profilescan-location-fragment start="344" end="385" dc-status="CONTINUOUS"/>
            </location-fragments>
            <alignment>EQIEKDVATMRELGIvDEGLAQKALKLMGGDLQAAIDLVFSG</alignment>
          </profilescan-location>
        </locations>
      </profilescan-match>
      <rpsblast-match>
        <signature ac="cd17039" desc="Ubl_ubiquitin_like" name="Ubl_ubiquitin_like">
          <signature-library-release library="CDD" version="3.18"/>
        </signature>
        <model-ac>cd17039</model-ac>
        <locations>
          <rpsblast-location evalue="5.15058E-7" score="44.8946" start="17" end="77">
            <location-fragments>
              <rpsblast-location-fragment start="17" end="77" dc-status="CONTINUOUS"/>
            </location-fragments>
            <sites/>
          </rpsblast-location>
        </locations>
      </rpsblast-match>
      <superfamilyhmmer3-match evalue="1.34E-7">
        <signature ac="SSF54236" name="Ubiquitin-like">
          <entry ac="IPR029071" desc="Ubiquitin-like domain superfamily" name="Ubiquitin-like_domsf" type="HOMOLOGOUS_SUPERFAMILY">
            <pathway-xref db="Reactome" id="R-CFA-9705462" name="Inactivation of CSF3 (G-CSF) signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-2173791" name="TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)"/>
            <pathway-xref db="Reactome" id="R-GGA-8849469" name="PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1"/>
            <pathway-xref db="Reactome" id="R-HSA-74749" name="Signal attenuation"/>
            <pathway-xref db="Reactome" id="R-SSC-5696395" name="Formation of Incision Complex in GG-NER"/>
            <pathway-xref db="Reactome" id="R-CEL-69601" name="Ubiquitin Mediated Degradation of Phosphorylated Cdc25A"/>
            <pathway-xref db="Reactome" id="R-HSA-2565942" name="Regulation of PLK1 Activity at G2/M Transition"/>
            <pathway-xref db="Reactome" id="R-HSA-5673001" name="RAF/MAP kinase cascade"/>
            <pathway-xref db="Reactome" id="R-CFA-5689877" name="Josephin domain DUBs"/>
            <pathway-xref db="Reactome" id="R-DME-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-CEL-3134975" name="Regulation of innate immune responses to cytosolic DNA"/>
            <pathway-xref db="Reactome" id="R-CFA-5689901" name="Metalloprotease DUBs"/>
            <pathway-xref db="Reactome" id="R-HSA-6791226" name="Major pathway of rRNA processing in the nucleolus and cytosol"/>
            <pathway-xref db="Reactome" id="R-MMU-2565942" name="Regulation of PLK1 Activity at G2/M Transition"/>
            <pathway-xref db="Reactome" id="R-DRE-372708" name="p130Cas linkage to MAPK signaling for integrins"/>
            <pathway-xref db="MetaCyc" id="PWY-7049" name="icosapentaenoate biosynthesis II (6-desaturase, mammals)"/>
            <pathway-xref db="Reactome" id="R-DME-8866654" name="E3 ubiquitin ligases ubiquitinate target proteins"/>
            <pathway-xref db="Reactome" id="R-MMU-6791226" name="Major pathway of rRNA processing in the nucleolus and cytosol"/>
            <pathway-xref db="Reactome" id="R-SCE-110312" name="Translesion synthesis by REV1"/>
            <pathway-xref db="Reactome" id="R-RNO-5675221" name="Negative regulation of MAPK pathway"/>
            <pathway-xref db="Reactome" id="R-GGA-5696400" name="Dual Incision in GG-NER"/>
            <pathway-xref db="Reactome" id="R-RNO-6804757" name="Regulation of TP53 Degradation"/>
            <pathway-xref db="Reactome" id="R-RNO-5621575" name="CD209 (DC-SIGN) signaling"/>
            <pathway-xref db="Reactome" id="R-DME-4608870" name="Asymmetric localization of PCP proteins"/>
            <pathway-xref db="Reactome" id="R-DME-4641262" name="Disassembly of the destruction complex and recruitment of AXIN to the membrane"/>
            <pathway-xref db="Reactome" id="R-CEL-180292" name="GAB1 signalosome"/>
            <pathway-xref db="Reactome" id="R-CFA-187577" name="SCF(Skp2)-mediated degradation of p27/p21"/>
            <pathway-xref db="Reactome" id="R-SPO-9664873" name="Pexophagy"/>
            <pathway-xref db="Reactome" id="R-RNO-6796648" name="TP53 Regulates Transcription of DNA Repair Genes"/>
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            <pathway-xref db="Reactome" id="R-SCE-72702" name="Ribosomal scanning and start codon recognition"/>
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            <pathway-xref db="Reactome" id="R-HSA-1912408" name="Pre-NOTCH Transcription and Translation"/>
            <pathway-xref db="Reactome" id="R-HSA-1236382" name="Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants"/>
            <pathway-xref db="Reactome" id="R-MMU-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-HSA-9615710" name="Late endosomal microautophagy"/>
            <pathway-xref db="Reactome" id="R-HSA-159236" name="Transport of Mature mRNA derived from an Intron-Containing Transcript"/>
            <pathway-xref db="Reactome" id="R-RNO-5689877" name="Josephin domain DUBs"/>
            <pathway-xref db="Reactome" id="R-MMU-159230" name="Transport of the SLBP Dependant Mature mRNA"/>
            <pathway-xref db="Reactome" id="R-HSA-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-MMU-5654733" name="Negative regulation of FGFR4 signaling"/>
            <pathway-xref db="Reactome" id="R-DDI-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-HSA-209560" name="NF-kB is activated and signals survival"/>
            <pathway-xref db="Reactome" id="R-HSA-936440" name="Negative regulators of DDX58/IFIH1 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-5637810" name="Constitutive Signaling by EGFRvIII"/>
            <pathway-xref db="Reactome" id="R-RNO-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-HSA-2559580" name="Oxidative Stress Induced Senescence"/>
            <pathway-xref db="Reactome" id="R-HSA-2173789" name="TGF-beta receptor signaling activates SMADs"/>
            <pathway-xref db="Reactome" id="R-MMU-159231" name="Transport of Mature mRNA Derived from an Intronless Transcript"/>
            <pathway-xref db="Reactome" id="R-MMU-6807004" name="Negative regulation of MET activity"/>
            <pathway-xref db="MetaCyc" id="PWY-6308" name="L-cysteine biosynthesis II (tRNA-dependent)"/>
            <pathway-xref db="Reactome" id="R-MMU-8856828" name="Clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-DDI-8866652" name="Synthesis of active ubiquitin: roles of E1 and E2 enzymes"/>
            <pathway-xref db="Reactome" id="R-RNO-159227" name="Transport of the SLBP independent Mature mRNA"/>
            <pathway-xref db="Reactome" id="R-HSA-8951664" name="Neddylation"/>
            <pathway-xref db="Reactome" id="R-MMU-8948751" name="Regulation of PTEN stability and activity"/>
            <pathway-xref db="Reactome" id="R-MMU-917729" name="Endosomal Sorting Complex Required For Transport (ESCRT)"/>
            <pathway-xref db="Reactome" id="R-HSA-426496" name="Post-transcriptional silencing by small RNAs"/>
            <pathway-xref db="Reactome" id="R-MMU-1295596" name="Spry regulation of FGF signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-5696395" name="Formation of Incision Complex in GG-NER"/>
            <pathway-xref db="Reactome" id="R-HSA-1295596" name="Spry regulation of FGF signaling"/>
            <pathway-xref db="Reactome" id="R-DME-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-8948751" name="Regulation of PTEN stability and activity"/>
            <pathway-xref db="MetaCyc" id="PWY-7366" name="phosphatidylglycerol degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-2559585" name="Oncogene Induced Senescence"/>
            <pathway-xref db="Reactome" id="R-BTA-5693571" name="Nonhomologous End-Joining (NHEJ)"/>
            <pathway-xref db="Reactome" id="R-HSA-5628897" name="TP53 Regulates Metabolic Genes"/>
            <pathway-xref db="Reactome" id="R-DRE-9020702" name="Interleukin-1 signaling"/>
            <pathway-xref db="Reactome" id="R-DME-8866652" name="Synthesis of active ubiquitin: roles of E1 and E2 enzymes"/>
            <pathway-xref db="Reactome" id="R-HSA-5689877" name="Josephin domain DUBs"/>
            <pathway-xref db="Reactome" id="R-HSA-8986944" name="Transcriptional Regulation by MECP2"/>
            <pathway-xref db="Reactome" id="R-DDI-5696394" name="DNA Damage Recognition in GG-NER"/>
            <pathway-xref db="Reactome" id="R-MMU-209543" name="p75NTR recruits signalling complexes"/>
            <pathway-xref db="Reactome" id="R-HSA-9022692" name="Regulation of MECP2 expression and activity"/>
            <pathway-xref db="Reactome" id="R-MMU-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-HSA-205043" name="NRIF signals cell death from the nucleus"/>
            <pathway-xref db="Reactome" id="R-HSA-182971" name="EGFR downregulation"/>
            <pathway-xref db="Reactome" id="R-MMU-2173789" name="TGF-beta receptor signaling activates SMADs"/>
            <pathway-xref db="Reactome" id="R-HSA-5205685" name="PINK1-PRKN Mediated Mitophagy"/>
            <pathway-xref db="Reactome" id="R-MMU-912631" name="Regulation of signaling by CBL"/>
            <pathway-xref db="Reactome" id="R-RNO-205043" name="NRIF signals cell death from the nucleus"/>
            <pathway-xref db="Reactome" id="R-SPO-8866652" name="Synthesis of active ubiquitin: roles of E1 and E2 enzymes"/>
            <pathway-xref db="Reactome" id="R-RNO-5205685" name="PINK1-PRKN Mediated Mitophagy"/>
            <pathway-xref db="Reactome" id="R-DDI-9013407" name="RHOH GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-7511" name="protein ubiquitination"/>
            <pathway-xref db="Reactome" id="R-MMU-159227" name="Transport of the SLBP independent Mature mRNA"/>
            <pathway-xref db="Reactome" id="R-HSA-5696395" name="Formation of Incision Complex in GG-NER"/>
            <pathway-xref db="Reactome" id="R-MMU-159236" name="Transport of Mature mRNA derived from an Intron-Containing Transcript"/>
            <pathway-xref db="Reactome" id="R-DME-5578749" name="Transcriptional regulation by small RNAs"/>
            <pathway-xref db="Reactome" id="R-CEL-532668" name="N-glycan trimming in the ER and Calnexin/Calreticulin cycle"/>
            <pathway-xref db="Reactome" id="R-SCE-8866652" name="Synthesis of active ubiquitin: roles of E1 and E2 enzymes"/>
            <pathway-xref db="Reactome" id="R-CEL-8951664" name="Neddylation"/>
            <pathway-xref db="MetaCyc" id="PWY-7884" name="lipoprotein posttranslational modification"/>
            <pathway-xref db="Reactome" id="R-MMU-8951664" name="Neddylation"/>
            <pathway-xref db="Reactome" id="R-SPO-8876198" name="RAB GEFs exchange GTP for GDP on RABs"/>
            <pathway-xref db="Reactome" id="R-RNO-159230" name="Transport of the SLBP Dependant Mature mRNA"/>
            <pathway-xref db="Reactome" id="R-SCE-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-DME-159227" name="Transport of the SLBP independent Mature mRNA"/>
            <pathway-xref db="Reactome" id="R-DRE-5693571" name="Nonhomologous End-Joining (NHEJ)"/>
            <pathway-xref db="Reactome" id="R-RNO-159236" name="Transport of Mature mRNA derived from an Intron-Containing Transcript"/>
            <pathway-xref db="Reactome" id="R-SCE-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-RNO-9664873" name="Pexophagy"/>
            <pathway-xref db="Reactome" id="R-RNO-209560" name="NF-kB is activated and signals survival"/>
            <pathway-xref db="Reactome" id="R-HSA-8849469" name="PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1"/>
            <pathway-xref db="Reactome" id="R-HSA-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-DRE-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-HSA-5654732" name="Negative regulation of FGFR3 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-5693565" name="Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"/>
            <pathway-xref db="Reactome" id="R-HSA-912631" name="Regulation of signaling by CBL"/>
            <pathway-xref db="Reactome" id="R-HSA-917729" name="Endosomal Sorting Complex Required For Transport (ESCRT)"/>
            <pathway-xref db="Reactome" id="R-HSA-8866652" name="Synthesis of active ubiquitin: roles of E1 and E2 enzymes"/>
            <pathway-xref db="Reactome" id="R-HSA-2028269" name="Signaling by Hippo"/>
            <pathway-xref db="Reactome" id="R-HSA-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-RNO-9013407" name="RHOH GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DME-159230" name="Transport of the SLBP Dependant Mature mRNA"/>
            <pathway-xref db="Reactome" id="R-HSA-9020702" name="Interleukin-1 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-2028269" name="Signaling by Hippo"/>
            <pathway-xref db="Reactome" id="R-SCE-8951664" name="Neddylation"/>
            <pathway-xref db="Reactome" id="R-SCE-8856828" name="Clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-HSA-5654727" name="Negative regulation of FGFR2 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-5205685" name="PINK1-PRKN Mediated Mitophagy"/>
            <pathway-xref db="Reactome" id="R-HSA-8934593" name="Regulation of RUNX1 Expression and Activity"/>
            <pathway-xref db="Reactome" id="R-SCE-5696395" name="Formation of Incision Complex in GG-NER"/>
            <pathway-xref db="Reactome" id="R-MMU-5689877" name="Josephin domain DUBs"/>
            <pathway-xref db="Reactome" id="R-SPO-159231" name="Transport of Mature mRNA Derived from an Intronless Transcript"/>
            <pathway-xref db="Reactome" id="R-RNO-9020702" name="Interleukin-1 signaling"/>
            <pathway-xref db="Reactome" id="R-DME-159231" name="Transport of Mature mRNA Derived from an Intronless Transcript"/>
            <pathway-xref db="Reactome" id="R-RNO-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-RNO-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-HSA-5687128" name="MAPK6/MAPK4 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-8948700" name="Competing endogenous RNAs (ceRNAs) regulate PTEN translation"/>
            <pathway-xref db="Reactome" id="R-BTA-5696394" name="DNA Damage Recognition in GG-NER"/>
            <pathway-xref db="Reactome" id="R-HSA-112126" name="ALKBH3 mediated reversal of alkylation damage"/>
            <pathway-xref db="Reactome" id="R-RNO-532668" name="N-glycan trimming in the ER and Calnexin/Calreticulin cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-5654726" name="Negative regulation of FGFR1 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-205043" name="NRIF signals cell death from the nucleus"/>
          </entry>
          <signature-library-release library="SUPERFAMILY" version="1.75"/>
        </signature>
        <model-ac>0050160</model-ac>
        <locations>
          <superfamilyhmmer3-location hmm-length="61" start="329" end="384">
            <location-fragments>
              <superfamilyhmmer3-location-fragment start="329" end="384" dc-status="CONTINUOUS"/>
            </location-fragments>
          </superfamilyhmmer3-location>
        </locations>
      </superfamilyhmmer3-match>
    </matches>
  </protein>
  <protein>
    <sequence md5="73e41b953e51afa3545ca0d455dfc21b">MFPIMERVSMSFVEYKIFPTQPSQDCLTLMAECLKVCQPFLHKYIWHMEPFRLKPVQEEHLYGKVYVGDNVEDEWFIISLLKYLSYQLPDSIVIRVLDEDGEILLIEAADHLPSWAQEPDLAEKRVYLYQGQVHLIPISDRPSSLTPLPSGVPREGDAVKTIVAFSHITRASPEVQECIDRRLGSYPRDWSSELHYCHLVVPKVIAHVLRESPQLISPAIQKLHDLDPQDSRMIQKMERFPQGPEKDLVTVGMGIPRCLYAMLSGSKIFPYKKSDWTLPGAEDAQFKAKYHGFKVAAGLEVMTSTQRNISHRSANDPAFDKFLKALNSLDYFQGLLPGSKEYEQFKGKARDFYRQDHPCDEIELENTPLYSTLFTHALATFDPSTPMKPEDVALKPADSDNWLDINPNVLDDLLAQRFLSKSRNDGTNISDLEHFLQESSDMKGVEGSRLTQGTKTNEGGISFDSNLFESALDKVLGMNLDSTDHSDSDDSESEREHDANEDDMRAYFEALEDQLKESNVTSDDLDLSQSAMRGDFRKRAHLPHNREGRIAPYSRDGRPGDRRRPHNQNSDEPSASTKFKSRGSAPTLDQIQADRLTDLANSYWAPHTLKKHKDFDPQVIRDVYSNDLRGTDFSIKRIMMLEFSQYFENYLWPNFSLDASNEHVLSVILMINEKFRERVPAWNSFQLKSEHFTCFFEKVLKLSLEDKSDVTLQEQKFVLVFLDHCFTSMEIDLIRVQVQKLVSLPMWASLLERRREFELKRIPKWRKYWKALQKKDAKESEEAKAKNEFDRHFLRKLIQRFLSTLDSIQEKDANPWAVEYCEHFLVLLIDLEALLPTRRFFDTLLDDSQVLAKCSLSSLAKREEGRLFAQLLNELKFYARFEISNETGDQLTEKQNLQLHYDKITSLQKAIFSRYPEMRKFALATVASIDDRESLTRHFGPLSKETLYKIAEFLCLVPELGTVDLKDFDEAVLREALILRHERKDSQLQALNELPLYPTEEVIWDENIVPGEFYNGEGVLALPKLNLQFLTLQDYLLRNFKLFQLESTYEIRGDVEDAVTRLKPWRPEDATVIFNGWARMAQPIVSFSIVEVAKPNIGEKQPSRVRADVSVNLSVKDNIKAEWENLRRHDVCFLVTVRPKISPHPVPLDFTDDFIPQVGLMYVRGCEVEGMLDENGRVIEEGPEPRPNLPGESRTYRILLDCNQYHQDMEKTSNGSEDVYESFNILMRRKPKENNFKAVLETIRELMNTSCVVPDFLHDIILGYGDPGAAHYRQMENQIKSLNFNDTFLSFDHLRQSFPNYDVTVDDNDKDRLVPPFKLEFKEMATNPGTTSETASEAKPSIKVTPFQPQTNGPFIVVHPKKNSVPFTPTQVEAIRAGMNPGLTMVVGPPGTGKTDVAVQIISNIYHNFPDQRTLIVTHSNQALNQLFEKIMSLDVDERHLLRLGHGEEALETEKDFSRYGRVNYVLAKRLELLDEVSRLQKSLDVRGDVAYTCETSGYFFLYEILSRWEKYETALKTVSAQETQKLDTVAQLFPFSKFFDKAPQPLFKKKSLDEDRLIAESCWRYIQDIFTQLEEFRAFELLRSGLDRTRYLVVKEAKIVAMTCTHAALKRKELASMGFKFDNILMEEAAQILEIETFIPLLLQNPEDGYNRLKRWIMIGDHHQLPPVIKNMAFQKFSNMEQSMFTRLVRLGVPTVDLDAQGRARPSIASLYNWRYKNLGNLSHVLNQDEFMAANGGFSFDYQLINVPDFNGVGESQPSPFFYQNLAEAEFVVATFMYMRLIGYPAEKISILTTYNGQKHLIRDVVNARCSNNPMVGTPHKITTVDKFQGQQNDYILLSLVRTYNVGHLRDVRRLVVAMSRARYGLYVFARVNLFKNCFELQPAFNILTKRPLQLHLCPNEVYRTKRQANVTAPNPLVISDMPAMCKFVYDFYAGKVAALQSIQPPSLGEQDKPGEIAITKPDGKTAQHPADDRDSDDEAEGRPNVVMKEIVNEVSAE</sequence>
    <xref id="TCALIF_00660-PA" name="TCALIF_00660-PA protein Name:&quot;Similar to Aqr Intron-binding protein aquarius (Mus musculus)&quot; AED:0.11 eAED:0.11 QI:0|0|0|0.75|1|1|4|0|1999"/>
    <matches>
      <hmmer3-match evalue="1.4E-31" score="110.2">
        <signature ac="PF13086" desc="AAA domain" name="AAA_11">
          <entry ac="IPR041677" desc="DNA2/NAM7 helicase, helicase domain" name="DNA2/NAM7_AAA_11" type="DOMAIN">
            <go-xref category="MOLECULAR_FUNCTION" db="GO" id="GO:0004386" name="helicase activity"/>
            <pathway-xref db="Reactome" id="R-SCE-69166" name="Removal of the Flap Intermediate"/>
            <pathway-xref db="Reactome" id="R-RNO-5693607" name="Processing of DNA double-strand break ends"/>
            <pathway-xref db="Reactome" id="R-MMU-975957" name="Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"/>
            <pathway-xref db="Reactome" id="R-HSA-6782210" name="Gap-filling DNA repair synthesis and ligation in TC-NER"/>
            <pathway-xref db="Reactome" id="R-RNO-5685942" name="HDR through Homologous Recombination (HRR)"/>
            <pathway-xref db="Reactome" id="R-CEL-975957" name="Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"/>
            <pathway-xref db="Reactome" id="R-MMU-6782210" name="Gap-filling DNA repair synthesis and ligation in TC-NER"/>
            <pathway-xref db="Reactome" id="R-MMU-5685938" name="HDR through Single Strand Annealing (SSA)"/>
            <pathway-xref db="Reactome" id="R-HSA-5685938" name="HDR through Single Strand Annealing (SSA)"/>
            <pathway-xref db="Reactome" id="R-MMU-6804756" name="Regulation of TP53 Activity through Phosphorylation"/>
            <pathway-xref db="Reactome" id="R-MMU-6782135" name="Dual incision in TC-NER"/>
            <pathway-xref db="Reactome" id="R-RNO-5693616" name="Presynaptic phase of homologous DNA pairing and strand exchange"/>
            <pathway-xref db="Reactome" id="R-MMU-400206" name="Regulation of lipid metabolism by PPARalpha"/>
            <pathway-xref db="Reactome" id="R-HSA-6782135" name="Dual incision in TC-NER"/>
            <pathway-xref db="Reactome" id="R-HSA-6804756" name="Regulation of TP53 Activity through Phosphorylation"/>
            <pathway-xref db="Reactome" id="R-HSA-72163" name="mRNA Splicing - Major Pathway"/>
            <pathway-xref db="Reactome" id="R-HSA-2426168" name="Activation of gene expression by SREBF (SREBP)"/>
            <pathway-xref db="Reactome" id="R-RNO-6804756" name="Regulation of TP53 Activity through Phosphorylation"/>
            <pathway-xref db="Reactome" id="R-MMU-5693568" name="Resolution of D-loop Structures through Holliday Junction Intermediates"/>
            <pathway-xref db="Reactome" id="R-HSA-5693616" name="Presynaptic phase of homologous DNA pairing and strand exchange"/>
            <pathway-xref db="Reactome" id="R-HSA-2151201" name="Transcriptional activation of mitochondrial biogenesis"/>
            <pathway-xref db="Reactome" id="R-RNO-5693568" name="Resolution of D-loop Structures through Holliday Junction Intermediates"/>
            <pathway-xref db="Reactome" id="R-DDI-975957" name="Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"/>
            <pathway-xref db="Reactome" id="R-HSA-9707564" name="Cytoprotection by HMOX1"/>
            <pathway-xref db="Reactome" id="R-HSA-69166" name="Removal of the Flap Intermediate"/>
            <pathway-xref db="Reactome" id="R-MMU-5693579" name="Homologous DNA Pairing and Strand Exchange"/>
            <pathway-xref db="Reactome" id="R-MMU-69473" name="G2/M DNA damage checkpoint"/>
            <pathway-xref db="Reactome" id="R-HSA-174437" name="Removal of the Flap Intermediate from the C-strand"/>
            <pathway-xref db="Reactome" id="R-DDI-975956" name="Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"/>
            <pathway-xref db="Reactome" id="R-MMU-69166" name="Removal of the Flap Intermediate"/>
            <pathway-xref db="Reactome" id="R-HSA-69473" name="G2/M DNA damage checkpoint"/>
            <pathway-xref db="Reactome" id="R-HSA-975956" name="Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"/>
            <pathway-xref db="Reactome" id="R-MMU-975956" name="Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"/>
            <pathway-xref db="Reactome" id="R-HSA-5693607" name="Processing of DNA double-strand break ends"/>
            <pathway-xref db="Reactome" id="R-MMU-6781823" name="Formation of TC-NER Pre-Incision Complex"/>
            <pathway-xref db="MetaCyc" id="PWY-7250" name="[2Fe-2S] iron-sulfur cluster biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-975956" name="Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"/>
            <pathway-xref db="Reactome" id="R-HSA-975957" name="Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"/>
            <pathway-xref db="Reactome" id="R-HSA-400206" name="Regulation of lipid metabolism by PPARalpha"/>
            <pathway-xref db="Reactome" id="R-RNO-174437" name="Removal of the Flap Intermediate from the C-strand"/>
            <pathway-xref db="Reactome" id="R-HSA-400253" name="Circadian Clock"/>
            <pathway-xref db="Reactome" id="R-HSA-1989781" name="PPARA activates gene expression"/>
            <pathway-xref db="Reactome" id="R-HSA-5685942" name="HDR through Homologous Recombination (HRR)"/>
            <pathway-xref db="Reactome" id="R-RNO-5685938" name="HDR through Single Strand Annealing (SSA)"/>
            <pathway-xref db="Reactome" id="R-MMU-5685942" name="HDR through Homologous Recombination (HRR)"/>
            <pathway-xref db="Reactome" id="R-MMU-72163" name="mRNA Splicing - Major Pathway"/>
            <pathway-xref db="Reactome" id="R-HSA-5693568" name="Resolution of D-loop Structures through Holliday Junction Intermediates"/>
            <pathway-xref db="Reactome" id="R-HSA-6781823" name="Formation of TC-NER Pre-Incision Complex"/>
            <pathway-xref db="Reactome" id="R-HSA-1368082" name="RORA activates gene expression"/>
            <pathway-xref db="Reactome" id="R-HSA-381340" name="Transcriptional regulation of white adipocyte differentiation"/>
            <pathway-xref db="Reactome" id="R-HSA-1368108" name="BMAL1:CLOCK,NPAS2 activates circadian gene expression"/>
            <pathway-xref db="Reactome" id="R-RNO-5693579" name="Homologous DNA Pairing and Strand Exchange"/>
            <pathway-xref db="Reactome" id="R-MMU-5693616" name="Presynaptic phase of homologous DNA pairing and strand exchange"/>
            <pathway-xref db="Reactome" id="R-HSA-5601884" name="PIWI-interacting RNA (piRNA) biogenesis"/>
            <pathway-xref db="Reactome" id="R-SCE-975957" name="Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"/>
            <pathway-xref db="Reactome" id="R-SPO-174437" name="Removal of the Flap Intermediate from the C-strand"/>
            <pathway-xref db="Reactome" id="R-HSA-9707616" name="Heme signaling"/>
            <pathway-xref db="Reactome" id="R-SPO-975957" name="Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"/>
            <pathway-xref db="Reactome" id="R-SPO-69166" name="Removal of the Flap Intermediate"/>
            <pathway-xref db="Reactome" id="R-HSA-5693579" name="Homologous DNA Pairing and Strand Exchange"/>
            <pathway-xref db="Reactome" id="R-RNO-69473" name="G2/M DNA damage checkpoint"/>
            <pathway-xref db="Reactome" id="R-MMU-174437" name="Removal of the Flap Intermediate from the C-strand"/>
            <pathway-xref db="Reactome" id="R-RNO-69166" name="Removal of the Flap Intermediate"/>
            <pathway-xref db="Reactome" id="R-DME-975956" name="Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"/>
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          </entry>
          <signature-library-release library="PFAM" version="34.0"/>
        </signature>
        <model-ac>PF13086</model-ac>
        <locations>
          <hmmer3-location env-end="1673" env-start="1366" post-processed="true" score="107.5" evalue="9.4E-31" hmm-start="5" hmm-end="260" hmm-length="261" hmm-bounds="INCOMPLETE" start="1370" end="1672">
            <location-fragments>
              <hmmer3-location-fragment start="1370" end="1672" dc-status="CONTINUOUS"/>
            </location-fragments>
          </hmmer3-location>
        </locations>
      </hmmer3-match>
      <hmmer3-match evalue="6.0E-27" score="94.6">
        <signature ac="PF13087" desc="AAA domain" name="AAA_12">
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            <pathway-xref db="MetaCyc" id="PWY-7735" name="echinomycin and triostin A biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-6682" name="dehydrophos biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-975957" name="Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"/>
            <pathway-xref db="MetaCyc" id="PWY-6339" name="syringate degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-5685942" name="HDR through Homologous Recombination (HRR)"/>
            <pathway-xref db="MetaCyc" id="PWY-7076" name="3,5-dimethoxytoluene biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8210" name="pyrrolomycin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6346" name="staurosporine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7440" name="dTDP-beta-L-4-epi-vancosamine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-8934593" name="Regulation of RUNX1 Expression and Activity"/>
            <pathway-xref db="MetaCyc" id="PWY-5301" name="ajmaline and sarpagine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7547" name="prodigiosin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-1061" name="homogalacturonan biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-4202" name="arsenic detoxification (mammals)"/>
            <pathway-xref db="Reactome" id="R-MMU-174437" name="Removal of the Flap Intermediate from the C-strand"/>
            <pathway-xref db="MetaCyc" id="PWY-6736" name="sulfur volatiles biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5287" name="sanguinarine and macarpine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7608" name="neoxaline biosynthesis"/>
          </entry>
          <signature-library-release library="PFAM" version="34.0"/>
        </signature>
        <model-ac>PF13087</model-ac>
        <locations>
          <hmmer3-location env-end="1874" env-start="1681" post-processed="true" score="93.0" evalue="1.8E-26" hmm-start="1" hmm-end="196" hmm-length="199" hmm-bounds="N_TERMINAL_COMPLETE" start="1681" end="1871">
            <location-fragments>
              <hmmer3-location-fragment start="1681" end="1871" dc-status="CONTINUOUS"/>
            </location-fragments>
          </hmmer3-location>
        </locations>
      </hmmer3-match>
      <hmmer3-match evalue="1.7E-29" score="104.6">
        <signature ac="G3DSA:3.40.50.300" name="">
          <entry ac="IPR027417" desc="P-loop containing nucleoside triphosphate hydrolase" name="P-loop_NTPase" type="HOMOLOGOUS_SUPERFAMILY">
            <pathway-xref db="Reactome" id="R-DME-399954" name="Sema3A PAK dependent Axon repulsion"/>
            <pathway-xref db="Reactome" id="R-HSA-5673001" name="RAF/MAP kinase cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-2565942" name="Regulation of PLK1 Activity at G2/M Transition"/>
            <pathway-xref db="Reactome" id="R-MMU-5620912" name="Anchoring of the basal body to the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-CEL-171007" name="p38MAPK events"/>
            <pathway-xref db="MetaCyc" id="PWY-6973" name="dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-6791226" name="Major pathway of rRNA processing in the nucleolus and cytosol"/>
            <pathway-xref db="Reactome" id="R-SCE-9696273" name="RND1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-SCE-110312" name="Translesion synthesis by REV1"/>
            <pathway-xref db="Reactome" id="R-HSA-2559586" name="DNA Damage/Telomere Stress Induced Senescence"/>
            <pathway-xref db="Reactome" id="R-GGA-5696400" name="Dual Incision in GG-NER"/>
            <pathway-xref db="MetaCyc" id="PWY-7177" name="UTP and CTP dephosphorylation II"/>
            <pathway-xref db="Reactome" id="R-HSA-5693616" name="Presynaptic phase of homologous DNA pairing and strand exchange"/>
            <pathway-xref db="Reactome" id="R-DME-4608870" name="Asymmetric localization of PCP proteins"/>
            <pathway-xref db="MetaCyc" id="PWY-7631" name="arctigenin and isoarctigenin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-209461" name="Ubiquitination and degradation of phosphorylated ARM"/>
            <pathway-xref db="Reactome" id="R-RNO-525793" name="Myogenesis"/>
            <pathway-xref db="Reactome" id="R-SPO-75955" name="RNA Polymerase II Transcription Elongation"/>
            <pathway-xref db="Reactome" id="R-SCE-72702" name="Ribosomal scanning and start codon recognition"/>
            <pathway-xref db="Reactome" id="R-SSC-8951664" name="Neddylation"/>
            <pathway-xref db="Reactome" id="R-HSA-9684325" name="Maturation of replicase proteins"/>
            <pathway-xref db="Reactome" id="R-MMU-1834941" name="STING mediated induction of host immune responses"/>
            <pathway-xref db="MetaCyc" id="PWY-7465" name="3,3'-thiodipropanoate degradation"/>
            <pathway-xref db="Reactome" id="R-DME-9668328" name="Sealing of the nuclear envelope (NE) by ESCRT-III"/>
            <pathway-xref db="Reactome" id="R-SPO-8856828" name="Clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-DDI-1660517" name="Synthesis of PIPs at the late endosome membrane"/>
            <pathway-xref db="Reactome" id="R-HSA-156902" name="Peptide chain elongation"/>
            <pathway-xref db="Reactome" id="R-SSC-8854050" name="FBXL7 down-regulates AURKA during mitotic entry and in early mitosis"/>
            <pathway-xref db="MetaCyc" id="PWY-2821" name="glucosinolate biosynthesis from phenylalanine"/>
            <pathway-xref db="Reactome" id="R-DME-2046106" name="alpha-linolenic acid (ALA) metabolism"/>
            <pathway-xref db="Reactome" id="R-DDI-2029482" name="Regulation of actin dynamics for phagocytic cup formation"/>
            <pathway-xref db="Reactome" id="R-HSA-196741" name="Cobalamin (Cbl, vitamin B12) transport and metabolism"/>
            <pathway-xref db="Reactome" id="R-RNO-1963640" name="GRB2 events in ERBB2 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-7714" name="harzianum A and trichodermin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-9648025" name="EML4 and NUDC in mitotic spindle formation"/>
            <pathway-xref db="MetaCyc" id="PWY-5987" name="sorgoleone biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-8854050" name="FBXL7 down-regulates AURKA during mitotic entry and in early mitosis"/>
            <pathway-xref db="Reactome" id="R-HSA-5578775" name="Ion homeostasis"/>
            <pathway-xref db="Reactome" id="R-DRE-3134975" name="Regulation of innate immune responses to cytosolic DNA"/>
            <pathway-xref db="Reactome" id="R-CEL-381676" name="Glucagon-like Peptide-1 (GLP1) regulates insulin secretion"/>
            <pathway-xref db="Reactome" id="R-HSA-174154" name="APC/C:Cdc20 mediated degradation of Securin"/>
            <pathway-xref db="Reactome" id="R-CEL-68949" name="Orc1 removal from chromatin"/>
            <pathway-xref db="Reactome" id="R-CEL-1234176" name="Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha"/>
            <pathway-xref db="Reactome" id="R-CEL-983170" name="Antigen Presentation: Folding, assembly and peptide loading of class I MHC"/>
            <pathway-xref db="Reactome" id="R-MMU-1655829" name="Regulation of cholesterol biosynthesis by SREBP (SREBF)"/>
            <pathway-xref db="Reactome" id="R-HSA-195253" name="Degradation of beta-catenin by the destruction complex"/>
            <pathway-xref db="Reactome" id="R-DDI-2485179" name="Activation of the phototransduction cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-9703465" name="Signaling by FLT3 fusion proteins"/>
            <pathway-xref db="Reactome" id="R-SPO-416482" name="G alpha (12/13) signalling events"/>
            <pathway-xref db="Reactome" id="R-CEL-204005" name="COPII-mediated vesicle transport"/>
            <pathway-xref db="Reactome" id="R-HSA-199992" name="trans-Golgi Network Vesicle Budding"/>
            <pathway-xref db="Reactome" id="R-GGA-72187" name="mRNA 3'-end processing"/>
            <pathway-xref db="Reactome" id="R-XTR-499943" name="Interconversion of nucleotide di- and triphosphates"/>
            <pathway-xref db="MetaCyc" id="PWY-7745" name="p-HBAD biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CFA-5663220" name="RHO GTPases Activate Formins"/>
            <pathway-xref db="Reactome" id="R-CEL-5673000" name="RAF activation"/>
            <pathway-xref db="Reactome" id="R-GGA-9648025" name="EML4 and NUDC in mitotic spindle formation"/>
            <pathway-xref db="Reactome" id="R-RNO-3108214" name="SUMOylation of DNA damage response and repair proteins"/>
            <pathway-xref db="MetaCyc" id="PWY-7585" name="docosahexaenoate biosynthesis II (bacteria)"/>
            <pathway-xref db="Reactome" id="R-HSA-1257604" name="PIP3 activates AKT signaling"/>
            <pathway-xref db="Reactome" id="R-DRE-5218921" name="VEGFR2 mediated cell proliferation"/>
            <pathway-xref db="Reactome" id="R-SPO-6811434" name="COPI-dependent Golgi-to-ER retrograde traffic"/>
            <pathway-xref db="Reactome" id="R-RNO-170968" name="Frs2-mediated activation"/>
            <pathway-xref db="Reactome" id="R-HSA-8963896" name="HDL assembly"/>
            <pathway-xref db="Reactome" id="R-SCE-532668" name="N-glycan trimming in the ER and Calnexin/Calreticulin cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-5353" name="arachidonate biosynthesis I (6-desaturase, lower eukaryotes)"/>
            <pathway-xref db="Reactome" id="R-HSA-68616" name="Assembly of the ORC complex at the origin of replication"/>
            <pathway-xref db="Reactome" id="R-PFA-6807878" name="COPI-mediated anterograde transport"/>
            <pathway-xref db="MetaCyc" id="PWY-6932" name="selenate reduction"/>
            <pathway-xref db="Reactome" id="R-SPO-72086" name="mRNA Capping"/>
            <pathway-xref db="Reactome" id="R-DME-5676590" name="NIK--&gt;noncanonical NF-kB signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-428930" name="Thromboxane signalling through TP receptor"/>
            <pathway-xref db="Reactome" id="R-RNO-5696400" name="Dual Incision in GG-NER"/>
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            <pathway-xref db="Reactome" id="R-HSA-166208" name="mTORC1-mediated signalling"/>
            <pathway-xref db="Reactome" id="R-MMU-5656169" name="Termination of translesion DNA synthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-5047" name="gibberellin biosynthesis IV (Gibberella fujikuroi)"/>
            <pathway-xref db="Reactome" id="R-MMU-389359" name="CD28 dependent Vav1 pathway"/>
            <pathway-xref db="Reactome" id="R-DME-170660" name="Adenylate cyclase activating pathway"/>
            <pathway-xref db="MetaCyc" id="PWY-6955" name="lincomycin A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-68949" name="Orc1 removal from chromatin"/>
            <pathway-xref db="Reactome" id="R-SCE-68616" name="Assembly of the ORC complex at the origin of replication"/>
            <pathway-xref db="Reactome" id="R-DDI-9013424" name="RHOV GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-SSC-4641257" name="Degradation of AXIN"/>
            <pathway-xref db="Reactome" id="R-DME-9013149" name="RAC1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DDI-72649" name="Translation initiation complex formation"/>
            <pathway-xref db="Reactome" id="R-SCE-69017" name="CDK-mediated phosphorylation and removal of Cdc6"/>
            <pathway-xref db="Reactome" id="R-DDI-68867" name="Assembly of the pre-replicative complex"/>
            <pathway-xref db="Reactome" id="R-MMU-5656121" name="Translesion synthesis by POLI"/>
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            <pathway-xref db="Reactome" id="R-MMU-2132295" name="MHC class II antigen presentation"/>
            <pathway-xref db="MetaCyc" id="PWY-7448" name="galloylated catechin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-350562" name="Regulation of ornithine decarboxylase (ODC)"/>
            <pathway-xref db="Reactome" id="R-GGA-392517" name="Rap1 signalling"/>
            <pathway-xref db="Reactome" id="R-SSC-179812" name="GRB2 events in EGFR signaling"/>
            <pathway-xref db="Reactome" id="R-DME-75955" name="RNA Polymerase II Transcription Elongation"/>
            <pathway-xref db="Reactome" id="R-GGA-5218921" name="VEGFR2 mediated cell proliferation"/>
            <pathway-xref db="Reactome" id="R-DRE-5696400" name="Dual Incision in GG-NER"/>
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            <pathway-xref db="Reactome" id="R-SPO-68962" name="Activation of the pre-replicative complex"/>
            <pathway-xref db="Reactome" id="R-GGA-182971" name="EGFR downregulation"/>
            <pathway-xref db="Reactome" id="R-RNO-5218921" name="VEGFR2 mediated cell proliferation"/>
            <pathway-xref db="Reactome" id="R-RNO-163841" name="Gamma carboxylation, hypusine formation and arylsulfatase activation"/>
            <pathway-xref db="Reactome" id="R-PFA-2514853" name="Condensation of Prometaphase Chromosomes"/>
            <pathway-xref db="Reactome" id="R-HSA-9679191" name="Potential therapeutics for SARS"/>
            <pathway-xref db="Reactome" id="R-CFA-3928665" name="EPH-ephrin mediated repulsion of cells"/>
            <pathway-xref db="Reactome" id="R-CFA-5693568" name="Resolution of D-loop Structures through Holliday Junction Intermediates"/>
            <pathway-xref db="Reactome" id="R-GGA-6811434" name="COPI-dependent Golgi-to-ER retrograde traffic"/>
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            <pathway-xref db="Reactome" id="R-DRE-9648025" name="EML4 and NUDC in mitotic spindle formation"/>
            <pathway-xref db="Reactome" id="R-SSC-350562" name="Regulation of ornithine decarboxylase (ODC)"/>
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            <pathway-xref db="Reactome" id="R-HSA-174184" name="Cdc20:Phospho-APC/C mediated degradation of Cyclin A"/>
            <pathway-xref db="MetaCyc" id="PWY-7752" name="gadusol biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-416482" name="G alpha (12/13) signalling events"/>
            <pathway-xref db="Reactome" id="R-GGA-8856828" name="Clathrin-mediated endocytosis"/>
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            <pathway-xref db="MetaCyc" id="PWY-7950" name="diadinoxanthin and fucoxanthin biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-PFA-499943" name="Interconversion of nucleotide di- and triphosphates"/>
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            <pathway-xref db="Reactome" id="R-DDI-8849471" name="PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases"/>
            <pathway-xref db="Reactome" id="R-HSA-429958" name="mRNA decay by 3' to 5' exoribonuclease"/>
            <pathway-xref db="MetaCyc" id="PWY-7569" name="arginomycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-2022854" name="Keratan sulfate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-3214847" name="HATs acetylate histones"/>
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            <pathway-xref db="Reactome" id="R-SSC-1433557" name="Signaling by SCF-KIT"/>
            <pathway-xref db="Reactome" id="R-DRE-1799339" name="SRP-dependent cotranslational protein targeting to membrane"/>
            <pathway-xref db="MetaCyc" id="PWY-5729" name="vestitol and sativan biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-5693579" name="Homologous DNA Pairing and Strand Exchange"/>
            <pathway-xref db="Reactome" id="R-SCE-8854050" name="FBXL7 down-regulates AURKA during mitotic entry and in early mitosis"/>
            <pathway-xref db="Reactome" id="R-BTA-2514859" name="Inactivation, recovery and regulation of the phototransduction cascade"/>
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            <pathway-xref db="Reactome" id="R-MMU-380320" name="Recruitment of NuMA to mitotic centrosomes"/>
            <pathway-xref db="Reactome" id="R-HSA-68877" name="Mitotic Prometaphase"/>
            <pathway-xref db="Reactome" id="R-MMU-1169092" name="Activation of RAS in B cells"/>
            <pathway-xref db="Reactome" id="R-MMU-983231" name="Factors involved in megakaryocyte development and platelet production"/>
            <pathway-xref db="Reactome" id="R-SCE-9696264" name="RND3 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-8148" name="NADP biosynthesis"/>
            <pathway-xref db="Reactome" id="R-BTA-74217" name="Purine salvage"/>
            <pathway-xref db="Reactome" id="R-HSA-390522" name="Striated Muscle Contraction"/>
            <pathway-xref db="Reactome" id="R-HSA-445355" name="Smooth Muscle Contraction"/>
            <pathway-xref db="Reactome" id="R-MMU-174411" name="Polymerase switching on the C-strand of the telomere"/>
            <pathway-xref db="Reactome" id="R-DME-73817" name="Purine ribonucleoside monophosphate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-917937" name="Iron uptake and transport"/>
            <pathway-xref db="Reactome" id="R-GGA-432722" name="Golgi Associated Vesicle Biogenesis"/>
            <pathway-xref db="Reactome" id="R-HSA-1989781" name="PPARA activates gene expression"/>
            <pathway-xref db="Reactome" id="R-DDI-429947" name="Deadenylation of mRNA"/>
            <pathway-xref db="Reactome" id="R-DME-5654704" name="SHC-mediated cascade:FGFR3"/>
            <pathway-xref db="Reactome" id="R-CEL-196741" name="Cobalamin (Cbl, vitamin B12) transport and metabolism"/>
            <pathway-xref db="Reactome" id="R-RNO-1799339" name="SRP-dependent cotranslational protein targeting to membrane"/>
            <pathway-xref db="Reactome" id="R-MMU-68949" name="Orc1 removal from chromatin"/>
            <pathway-xref db="Reactome" id="R-GGA-5674135" name="MAP2K and MAPK activation"/>
            <pathway-xref db="MetaCyc" id="PWY-7977" name="L-methionine biosynthesis IV"/>
            <pathway-xref db="Reactome" id="R-RNO-8873719" name="RAB geranylgeranylation"/>
            <pathway-xref db="Reactome" id="R-HSA-171007" name="p38MAPK events"/>
            <pathway-xref db="Reactome" id="R-SPO-174362" name="Transport and synthesis of PAPS"/>
            <pathway-xref db="Reactome" id="R-SPO-9603798" name="Class I peroxisomal membrane protein import"/>
            <pathway-xref db="Reactome" id="R-GGA-1963640" name="GRB2 events in ERBB2 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-375165" name="NCAM signaling for neurite out-growth"/>
            <pathway-xref db="Reactome" id="R-SCE-77075" name="RNA Pol II CTD phosphorylation and interaction with CE"/>
            <pathway-xref db="Reactome" id="R-SCE-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7363" name="papaverine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-5674135" name="MAP2K and MAPK activation"/>
            <pathway-xref db="Reactome" id="R-RNO-844456" name="The NLRP3 inflammasome"/>
            <pathway-xref db="Reactome" id="R-DDI-113418" name="Formation of the Early Elongation Complex"/>
            <pathway-xref db="MetaCyc" id="PWY-8076" name="8-O-methylated benzoxazinoid glucoside biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7534" name="gliotoxin inactivation"/>
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            <pathway-xref db="Reactome" id="R-DRE-111459" name="Activation of caspases through apoptosome-mediated cleavage"/>
            <pathway-xref db="Reactome" id="R-MMU-209563" name="Axonal growth stimulation"/>
            <pathway-xref db="Reactome" id="R-HSA-163210" name="Formation of ATP by chemiosmotic coupling"/>
            <pathway-xref db="Reactome" id="R-CEL-1963640" name="GRB2 events in ERBB2 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-380972" name="Energy dependent regulation of mTOR by LKB1-AMPK"/>
            <pathway-xref db="MetaCyc" id="PWY-7643" name="coniferyl alcohol 9-methyl ester biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-6811434" name="COPI-dependent Golgi-to-ER retrograde traffic"/>
            <pathway-xref db="Reactome" id="R-DRE-9013423" name="RAC3 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DRE-5673000" name="RAF activation"/>
            <pathway-xref db="Reactome" id="R-CEL-1169092" name="Activation of RAS in B cells"/>
            <pathway-xref db="MetaCyc" id="PWY-7565" name="aspyridone A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SSC-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-418889" name="Caspase activation via Dependence Receptors in the absence of ligand"/>
            <pathway-xref db="Reactome" id="R-HSA-8943723" name="Regulation of PTEN mRNA translation"/>
            <pathway-xref db="Reactome" id="R-DDI-1369007" name="Mitochondrial ABC transporters"/>
            <pathway-xref db="Reactome" id="R-DRE-8873719" name="RAB geranylgeranylation"/>
            <pathway-xref db="Reactome" id="R-DME-68962" name="Activation of the pre-replicative complex"/>
            <pathway-xref db="Reactome" id="R-DME-3247509" name="Chromatin modifying enzymes"/>
            <pathway-xref db="Reactome" id="R-DME-376172" name="DSCAM interactions"/>
            <pathway-xref db="Reactome" id="R-DDI-190873" name="Gap junction degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7689" name="8-O-methylfusarubin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-114604" name="GPVI-mediated activation cascade"/>
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            <pathway-xref db="Reactome" id="R-DRE-1810476" name="RIP-mediated NFkB activation via ZBP1"/>
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            <pathway-xref db="MetaCyc" id="PWY-5530" name="sorbitol biosynthesis II"/>
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            <pathway-xref db="Reactome" id="R-BTA-1632852" name="Macroautophagy"/>
            <pathway-xref db="Reactome" id="R-RNO-179812" name="GRB2 events in EGFR signaling"/>
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            <pathway-xref db="Reactome" id="R-RNO-5673000" name="RAF activation"/>
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            <pathway-xref db="Reactome" id="R-HSA-381676" name="Glucagon-like Peptide-1 (GLP1) regulates insulin secretion"/>
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            <pathway-xref db="Reactome" id="R-MMU-5673000" name="RAF activation"/>
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            <pathway-xref db="Reactome" id="R-SSC-2029482" name="Regulation of actin dynamics for phagocytic cup formation"/>
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            <pathway-xref db="Reactome" id="R-RNO-917977" name="Transferrin endocytosis and recycling"/>
            <pathway-xref db="Reactome" id="R-MMU-77387" name="Insulin receptor recycling"/>
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            <pathway-xref db="MetaCyc" id="PWY-8260" name="roxarsone degradation I"/>
            <pathway-xref db="Reactome" id="R-DME-1250347" name="SHC1 events in ERBB4 signaling"/>
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            <pathway-xref db="Reactome" id="R-SSC-8875656" name="MET receptor recycling"/>
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            <pathway-xref db="Reactome" id="R-RNO-5654712" name="FRS-mediated FGFR4 signaling"/>
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            <pathway-xref db="MetaCyc" id="PWY-6581" name="spirilloxanthin and 2,2'-diketo-spirilloxanthin biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-DME-1632852" name="Macroautophagy"/>
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            <pathway-xref db="MetaCyc" id="PWY-7025" name="gentamicin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-5696397" name="Gap-filling DNA repair synthesis and ligation in GG-NER"/>
            <pathway-xref db="MetaCyc" id="PWY-6795" name="diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-HSA-9013424" name="RHOV GTPase cycle"/>
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            <pathway-xref db="Reactome" id="R-XTR-9013419" name="RHOT2 GTPase cycle"/>
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            <pathway-xref db="Reactome" id="R-BTA-5663220" name="RHO GTPases Activate Formins"/>
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            <pathway-xref db="Reactome" id="R-DRE-6811434" name="COPI-dependent Golgi-to-ER retrograde traffic"/>
            <pathway-xref db="MetaCyc" id="PWY-7007" name="methyl ketone biosynthesis (engineered)"/>
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            <pathway-xref db="Reactome" id="R-CFA-376172" name="DSCAM interactions"/>
            <pathway-xref db="MetaCyc" id="PWY-7658" name="protein N-glycosylation (Methanococcus voltae)"/>
            <pathway-xref db="Reactome" id="R-SPO-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-HSA-5696394" name="DNA Damage Recognition in GG-NER"/>
            <pathway-xref db="Reactome" id="R-CFA-382556" name="ABC-family proteins mediated transport"/>
            <pathway-xref db="Reactome" id="R-MMU-418594" name="G alpha (i) signalling events"/>
            <pathway-xref db="Reactome" id="R-MMU-975956" name="Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"/>
            <pathway-xref db="Reactome" id="R-GGA-9646399" name="Aggrephagy"/>
            <pathway-xref db="Reactome" id="R-CFA-6811434" name="COPI-dependent Golgi-to-ER retrograde traffic"/>
            <pathway-xref db="Reactome" id="R-MMU-1810476" name="RIP-mediated NFkB activation via ZBP1"/>
            <pathway-xref db="Reactome" id="R-CEL-9646399" name="Aggrephagy"/>
            <pathway-xref db="Reactome" id="R-BTA-4086400" name="PCP/CE pathway"/>
            <pathway-xref db="Reactome" id="R-DDI-432722" name="Golgi Associated Vesicle Biogenesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-7376" name="cob(II)yrinate a,c-diamide biosynthesis II (late cobalt incorporation)"/>
            <pathway-xref db="MetaCyc" id="PWY-7655" name="dechlorogriseofulvin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7607" name="meleagrin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DRE-9627069" name="Regulation of the apoptosome activity"/>
            <pathway-xref db="Reactome" id="R-RNO-141444" name="Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"/>
            <pathway-xref db="Reactome" id="R-RNO-390522" name="Striated Muscle Contraction"/>
            <pathway-xref db="MetaCyc" id="PWY-7765" name="3-hydroxy-4-methyl-anthranilate biosynthesis II"/>
            <pathway-xref db="Reactome" id="R-GGA-3371511" name="HSF1 activation"/>
            <pathway-xref db="Reactome" id="R-DDI-2467813" name="Separation of Sister Chromatids"/>
            <pathway-xref db="MetaCyc" id="PWY-7155" name="7-dehydroporiferasterol biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DRE-354192" name="Integrin signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-190873" name="Gap junction degradation"/>
            <pathway-xref db="Reactome" id="R-SSC-9020702" name="Interleukin-1 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-4641257" name="Degradation of AXIN"/>
            <pathway-xref db="Reactome" id="R-DME-5607764" name="CLEC7A (Dectin-1) signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-5336415" name="Uptake and function of diphtheria toxin"/>
            <pathway-xref db="Reactome" id="R-SSC-2132295" name="MHC class II antigen presentation"/>
            <pathway-xref db="MetaCyc" id="PWY-6320" name="phaselate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-5649702" name="APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway"/>
            <pathway-xref db="Reactome" id="R-CEL-4641258" name="Degradation of DVL"/>
            <pathway-xref db="Reactome" id="R-GGA-8964616" name="G beta:gamma signalling through CDC42"/>
            <pathway-xref db="MetaCyc" id="PWY-5975" name="furaneol and mesifurane biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-2564830" name="Cytosolic iron-sulfur cluster assembly"/>
            <pathway-xref db="MetaCyc" id="PWY-4621" name="arsenic detoxification (yeast)"/>
            <pathway-xref db="MetaCyc" id="PWY-6946" name="cholesterol degradation to androstenedione II (cholesterol dehydrogenase)"/>
            <pathway-xref db="Reactome" id="R-SSC-9013423" name="RAC3 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DDI-187577" name="SCF(Skp2)-mediated degradation of p27/p21"/>
            <pathway-xref db="Reactome" id="R-RNO-3371497" name="HSP90 chaperone cycle for steroid hormone receptors (SHR)"/>
            <pathway-xref db="Reactome" id="R-SCE-156842" name="Eukaryotic Translation Elongation"/>
            <pathway-xref db="Reactome" id="R-HSA-5625970" name="RHO GTPases activate KTN1"/>
            <pathway-xref db="Reactome" id="R-DME-5620924" name="Intraflagellar transport"/>
            <pathway-xref db="MetaCyc" id="PWY-7193" name="pyrimidine ribonucleosides salvage I"/>
            <pathway-xref db="Reactome" id="R-DME-6785631" name="ERBB2 Regulates Cell Motility"/>
            <pathway-xref db="Reactome" id="R-DDI-9648002" name="RAS processing"/>
            <pathway-xref db="Reactome" id="R-SSC-5687128" name="MAPK6/MAPK4 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-6919" name="neopentalenoketolactone and pentalenate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DRE-9634635" name="Estrogen-stimulated signaling through PRKCZ"/>
            <pathway-xref db="Reactome" id="R-RNO-5694530" name="Cargo concentration in the ER"/>
            <pathway-xref db="Reactome" id="R-HSA-75153" name="Apoptotic execution phase"/>
            <pathway-xref db="Reactome" id="R-SCE-499943" name="Interconversion of nucleotide di- and triphosphates"/>
            <pathway-xref db="Reactome" id="R-DME-5654706" name="FRS-mediated FGFR3 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-7439" name="dTDP-beta-L-evernitrose biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8082" name="glycine lipid biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-9707564" name="Cytoprotection by HMOX1"/>
            <pathway-xref db="Reactome" id="R-HSA-8853334" name="Signaling by FGFR3 fusions in cancer"/>
            <pathway-xref db="MetaCyc" id="PWY-7769" name="phosalacine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-432626" name="Circadian Clock pathway"/>
            <pathway-xref db="Reactome" id="R-HSA-1236382" name="Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants"/>
            <pathway-xref db="Reactome" id="R-CEL-5624138" name="Trafficking of myristoylated proteins to the cilium"/>
            <pathway-xref db="Reactome" id="R-DRE-354194" name="GRB2:SOS provides linkage to MAPK signaling for Integrins"/>
            <pathway-xref db="MetaCyc" id="PWY-7058" name="esculetin modification"/>
            <pathway-xref db="Reactome" id="R-RNO-75953" name="RNA Polymerase II Transcription Initiation"/>
            <pathway-xref db="Reactome" id="R-GGA-1169408" name="ISG15 antiviral mechanism"/>
            <pathway-xref db="Reactome" id="R-RNO-606279" name="Deposition of new CENPA-containing nucleosomes at the centromere"/>
            <pathway-xref db="Reactome" id="R-DME-5656169" name="Termination of translesion DNA synthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-8939236" name="RUNX1 regulates transcription of genes involved in differentiation of HSCs"/>
            <pathway-xref db="Reactome" id="R-RNO-4608870" name="Asymmetric localization of PCP proteins"/>
            <pathway-xref db="Reactome" id="R-SPO-983189" name="Kinesins"/>
            <pathway-xref db="Reactome" id="R-HSA-75953" name="RNA Polymerase II Transcription Initiation"/>
            <pathway-xref db="Reactome" id="R-BTA-1799339" name="SRP-dependent cotranslational protein targeting to membrane"/>
            <pathway-xref db="MetaCyc" id="PWY-7726" name="(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)"/>
            <pathway-xref db="Reactome" id="R-DRE-9013149" name="RAC1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-5654699" name="SHC-mediated cascade:FGFR2"/>
            <pathway-xref db="Reactome" id="R-DRE-6782135" name="Dual incision in TC-NER"/>
            <pathway-xref db="Reactome" id="R-DME-381753" name="Olfactory Signaling Pathway"/>
            <pathway-xref db="Reactome" id="R-RNO-75153" name="Apoptotic execution phase"/>
            <pathway-xref db="Reactome" id="R-SPO-110314" name="Recognition of DNA damage by PCNA-containing replication complex"/>
            <pathway-xref db="Reactome" id="R-MMU-3928664" name="Ephrin signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-8167" name="bis(tungstenpterin) cofactor biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SSC-72187" name="mRNA 3'-end processing"/>
            <pathway-xref db="Reactome" id="R-DME-5218921" name="VEGFR2 mediated cell proliferation"/>
            <pathway-xref db="Reactome" id="R-MMU-432720" name="Lysosome Vesicle Biogenesis"/>
            <pathway-xref db="Reactome" id="R-SPO-6796648" name="TP53 Regulates Transcription of DNA Repair Genes"/>
            <pathway-xref db="Reactome" id="R-HSA-5621480" name="Dectin-2 family"/>
            <pathway-xref db="MetaCyc" id="PWY-7954" name="tabtoxinine-beta-lactam biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-6782135" name="Dual incision in TC-NER"/>
            <pathway-xref db="Reactome" id="R-MMU-450321" name="JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1"/>
            <pathway-xref db="Reactome" id="R-HSA-9010553" name="Regulation of expression of SLITs and ROBOs"/>
            <pathway-xref db="Reactome" id="R-CEL-445144" name="Signal transduction by L1"/>
            <pathway-xref db="Reactome" id="R-SSC-174154" name="APC/C:Cdc20 mediated degradation of Securin"/>
            <pathway-xref db="Reactome" id="R-DDI-69091" name="Polymerase switching"/>
            <pathway-xref db="MetaCyc" id="PWY-7221" name="guanosine ribonucleotides de novo biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7352" name="daunorubicin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SCE-9707564" name="Cytoprotection by HMOX1"/>
            <pathway-xref db="Reactome" id="R-MMU-936440" name="Negative regulators of DDX58/IFIH1 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-8095" name="5-methoxy-6-methylbenzimidazole biosynthesis (anaerobic)"/>
            <pathway-xref db="Reactome" id="R-RNO-9696270" name="RND2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MTU-936635" name="Sulfate assimilation"/>
            <pathway-xref db="Reactome" id="R-DME-9013420" name="RHOU GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-76042" name="RNA Polymerase II Transcription Initiation And Promoter Clearance"/>
            <pathway-xref db="Reactome" id="R-RNO-156842" name="Eukaryotic Translation Elongation"/>
            <pathway-xref db="MetaCyc" id="PWY-2681" name="trans-zeatin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DRE-114608" name="Platelet degranulation"/>
            <pathway-xref db="Reactome" id="R-DDI-5696395" name="Formation of Incision Complex in GG-NER"/>
            <pathway-xref db="Reactome" id="R-GGA-9013106" name="RHOC GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DME-73614" name="Pyrimidine salvage"/>
            <pathway-xref db="MetaCyc" id="PWY-7402" name="benzoate fermentation (to acetate and cyclohexane carboxylate)"/>
            <pathway-xref db="Reactome" id="R-DRE-5578749" name="Transcriptional regulation by small RNAs"/>
            <pathway-xref db="Reactome" id="R-HSA-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-GGA-975957" name="Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"/>
            <pathway-xref db="Reactome" id="R-DME-8854214" name="TBC/RABGAPs"/>
            <pathway-xref db="MetaCyc" id="PWY-5526" name="bacteriochlorophyll a biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8184" name="L-isoleucine degradation III (oxidative Stickland reaction)"/>
            <pathway-xref db="Reactome" id="R-RNO-432722" name="Golgi Associated Vesicle Biogenesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7176" name="UTP and CTP de novo biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-4983" name="nitric oxide biosynthesis II (mammals)"/>
            <pathway-xref db="Reactome" id="R-HSA-5693548" name="Sensing of DNA Double Strand Breaks"/>
            <pathway-xref db="Reactome" id="R-HSA-8948751" name="Regulation of PTEN stability and activity"/>
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            <pathway-xref db="Reactome" id="R-CFA-9707564" name="Cytoprotection by HMOX1"/>
            <pathway-xref db="Reactome" id="R-SSC-5625970" name="RHO GTPases activate KTN1"/>
            <pathway-xref db="Reactome" id="R-SCE-5656169" name="Termination of translesion DNA synthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-1236978" name="Cross-presentation of soluble exogenous antigens (endosomes)"/>
            <pathway-xref db="Reactome" id="R-SSC-5654700" name="FRS-mediated FGFR2 signaling"/>
            <pathway-xref db="Reactome" id="R-DDI-114608" name="Platelet degranulation"/>
            <pathway-xref db="Reactome" id="R-DDI-3371497" name="HSP90 chaperone cycle for steroid hormone receptors (SHR)"/>
            <pathway-xref db="Reactome" id="R-MMU-2514853" name="Condensation of Prometaphase Chromosomes"/>
            <pathway-xref db="Reactome" id="R-DDI-418597" name="G alpha (z) signalling events"/>
            <pathway-xref db="Reactome" id="R-BTA-5358493" name="Synthesis of diphthamide-EEF2"/>
            <pathway-xref db="Reactome" id="R-DME-532668" name="N-glycan trimming in the ER and Calnexin/Calreticulin cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-6799198" name="Complex I biogenesis"/>
            <pathway-xref db="Reactome" id="R-RNO-382556" name="ABC-family proteins mediated transport"/>
            <pathway-xref db="Reactome" id="R-SPO-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-DME-3108214" name="SUMOylation of DNA damage response and repair proteins"/>
            <pathway-xref db="Reactome" id="R-DDI-72695" name="Formation of the ternary complex, and subsequently, the 43S complex"/>
            <pathway-xref db="Reactome" id="R-SSC-389359" name="CD28 dependent Vav1 pathway"/>
            <pathway-xref db="Reactome" id="R-HSA-9033241" name="Peroxisomal protein import"/>
            <pathway-xref db="Reactome" id="R-CEL-428930" name="Thromboxane signalling through TP receptor"/>
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            <pathway-xref db="Reactome" id="R-DME-8876725" name="Protein methylation"/>
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            <pathway-xref db="MetaCyc" id="PWY-7614" name="methiin metabolism"/>
            <pathway-xref db="Reactome" id="R-SPO-3371511" name="HSF1 activation"/>
            <pathway-xref db="Reactome" id="R-HSA-918233" name="TRAF3-dependent IRF activation pathway"/>
            <pathway-xref db="Reactome" id="R-CEL-170968" name="Frs2-mediated activation"/>
            <pathway-xref db="MetaCyc" id="PWY-4801" name="aloesone biosynthesis I"/>
            <pathway-xref db="Reactome" id="R-SPO-975956" name="Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)"/>
            <pathway-xref db="Reactome" id="R-DME-203927" name="MicroRNA (miRNA) biogenesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5278" name="sulfite oxidation III"/>
            <pathway-xref db="Reactome" id="R-BTA-5620922" name="BBSome-mediated cargo-targeting to cilium"/>
            <pathway-xref db="MetaCyc" id="PWY-6995" name="5-hydroxymethylfurfural degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-6804756" name="Regulation of TP53 Activity through Phosphorylation"/>
            <pathway-xref db="Reactome" id="R-MMU-1433557" name="Signaling by SCF-KIT"/>
            <pathway-xref db="Reactome" id="R-SSC-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-MMU-9670095" name="Inhibition of DNA recombination at telomere"/>
            <pathway-xref db="Reactome" id="R-CEL-983231" name="Factors involved in megakaryocyte development and platelet production"/>
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            <pathway-xref db="Reactome" id="R-HSA-426486" name="Small interfering RNA (siRNA) biogenesis"/>
            <pathway-xref db="Reactome" id="R-CFA-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-SPO-9013425" name="RHOT1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-BTA-110320" name="Translesion Synthesis by POLH"/>
            <pathway-xref db="Reactome" id="R-XTR-381676" name="Glucagon-like Peptide-1 (GLP1) regulates insulin secretion"/>
            <pathway-xref db="Reactome" id="R-DRE-416572" name="Sema4D induced cell migration and growth-cone collapse"/>
            <pathway-xref db="Reactome" id="R-DDI-1632852" name="Macroautophagy"/>
            <pathway-xref db="Reactome" id="R-HSA-373752" name="Netrin-1 signaling"/>
            <pathway-xref db="Reactome" id="R-DDI-174113" name="SCF-beta-TrCP mediated degradation of Emi1"/>
            <pathway-xref db="Reactome" id="R-SCE-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="MetaCyc" id="PWY-8257" name="Escherichia coli serotype O:52 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-5651801" name="PCNA-Dependent Long Patch Base Excision Repair"/>
            <pathway-xref db="MetaCyc" id="PWY-5475" name="pentagalloylglucose biosynthesis"/>
            <pathway-xref db="Reactome" id="R-BTA-9013408" name="RHOG GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-375165" name="NCAM signaling for neurite out-growth"/>
            <pathway-xref db="MetaCyc" id="PWY-7733" name="3-hydroxyquinaldate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-8949664" name="Processing of SMDT1"/>
            <pathway-xref db="Reactome" id="R-DME-4086398" name="Ca2+ pathway"/>
            <pathway-xref db="Reactome" id="R-SCE-8964058" name="HDL remodeling"/>
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            <pathway-xref db="Reactome" id="R-MMU-5627123" name="RHO GTPases activate PAKs"/>
            <pathway-xref db="Reactome" id="R-SCE-9013026" name="RHOB GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-5683371" name="Defective ABCB6 causes MCOPCB7"/>
            <pathway-xref db="MetaCyc" id="PWY-7669" name="equisetin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CFA-9013026" name="RHOB GTPase cycle"/>
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            <pathway-xref db="Reactome" id="R-HSA-5627117" name="RHO GTPases Activate ROCKs"/>
            <pathway-xref db="Reactome" id="R-DME-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-1236394" name="Signaling by ERBB4"/>
            <pathway-xref db="Reactome" id="R-SPO-499943" name="Interconversion of nucleotide di- and triphosphates"/>
            <pathway-xref db="Reactome" id="R-RNO-5610780" name="Degradation of GLI1 by the proteasome"/>
            <pathway-xref db="Reactome" id="R-HSA-420029" name="Tight junction interactions"/>
            <pathway-xref db="Reactome" id="R-RNO-170670" name="Adenylate cyclase inhibitory pathway"/>
            <pathway-xref db="Reactome" id="R-DME-5358493" name="Synthesis of diphthamide-EEF2"/>
            <pathway-xref db="Reactome" id="R-GGA-5654688" name="SHC-mediated cascade:FGFR1"/>
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            <pathway-xref db="MetaCyc" id="PWY-181" name="photorespiration"/>
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            <pathway-xref db="MetaCyc" id="PWY-7659" name="viridicatumtoxin biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-HSA-110314" name="Recognition of DNA damage by PCNA-containing replication complex"/>
            <pathway-xref db="Reactome" id="R-MMU-202040" name="G-protein activation"/>
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            <pathway-xref db="Reactome" id="R-HSA-166016" name="Toll Like Receptor 4 (TLR4) Cascade"/>
            <pathway-xref db="MetaCyc" id="PWY-7948" name="4-oxopentanoate degradation"/>
            <pathway-xref db="Reactome" id="R-DDI-159418" name="Recycling of bile acids and salts"/>
            <pathway-xref db="MetaCyc" id="PWY-8250" name="Escherichia coli serotype O:9 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-182971" name="EGFR downregulation"/>
            <pathway-xref db="Reactome" id="R-RNO-5578749" name="Transcriptional regulation by small RNAs"/>
            <pathway-xref db="Reactome" id="R-DME-9020702" name="Interleukin-1 signaling"/>
            <pathway-xref db="Reactome" id="R-DME-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-SCE-5696395" name="Formation of Incision Complex in GG-NER"/>
            <pathway-xref db="Reactome" id="R-SCE-983231" name="Factors involved in megakaryocyte development and platelet production"/>
            <pathway-xref db="Reactome" id="R-SPO-73614" name="Pyrimidine salvage"/>
            <pathway-xref db="Reactome" id="R-HSA-438066" name="Unblocking of NMDA receptors, glutamate binding and activation"/>
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            <pathway-xref db="Reactome" id="R-GGA-68827" name="CDT1 association with the CDC6:ORC:origin complex"/>
            <pathway-xref db="Reactome" id="R-HSA-5632968" name="Defective Mismatch Repair Associated With MSH6"/>
            <pathway-xref db="Reactome" id="R-HSA-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-75153" name="Apoptotic execution phase"/>
            <pathway-xref db="MetaCyc" id="PWY-6613" name="tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate"/>
            <pathway-xref db="Reactome" id="R-MMU-4608870" name="Asymmetric localization of PCP proteins"/>
            <pathway-xref db="Reactome" id="R-HSA-844456" name="The NLRP3 inflammasome"/>
            <pathway-xref db="Reactome" id="R-MMU-174362" name="Transport and synthesis of PAPS"/>
            <pathway-xref db="Reactome" id="R-RNO-5654700" name="FRS-mediated FGFR2 signaling"/>
            <pathway-xref db="Reactome" id="R-SPO-9013419" name="RHOT2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DME-429947" name="Deadenylation of mRNA"/>
            <pathway-xref db="Reactome" id="R-DME-68867" name="Assembly of the pre-replicative complex"/>
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            <pathway-xref db="Reactome" id="R-HSA-450302" name="activated TAK1 mediates p38 MAPK activation"/>
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            <pathway-xref db="Reactome" id="R-PFA-77387" name="Insulin receptor recycling"/>
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            <pathway-xref db="Reactome" id="R-SPO-72702" name="Ribosomal scanning and start codon recognition"/>
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            <pathway-xref db="Reactome" id="R-BTA-9013406" name="RHOQ GTPase cycle"/>
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            <pathway-xref db="Reactome" id="R-RNO-189483" name="Heme degradation"/>
            <pathway-xref db="Reactome" id="R-CFA-8980692" name="RHOA GTPase cycle"/>
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            <pathway-xref db="Reactome" id="R-MMU-73762" name="RNA Polymerase I Transcription Initiation"/>
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            <pathway-xref db="Reactome" id="R-CEL-5693548" name="Sensing of DNA Double Strand Breaks"/>
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            <pathway-xref db="Reactome" id="R-HSA-1234176" name="Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha"/>
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            <pathway-xref db="MetaCyc" id="PWY-7564" name="bacimethrin and bacimethrin pyrophosphate biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-RNO-112308" name="Presynaptic depolarization and calcium channel opening"/>
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            <pathway-xref db="Reactome" id="R-RNO-420092" name="Glucagon-type ligand receptors"/>
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            <pathway-xref db="MetaCyc" id="PWY-6148" name="tetrahydromethanopterin biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-RNO-2142691" name="Synthesis of Leukotrienes (LT) and Eoxins (EX)"/>
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            <pathway-xref db="MetaCyc" id="PWY-5875" name="staphyloxanthin biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-SCE-2046106" name="alpha-linolenic acid (ALA) metabolism"/>
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            <pathway-xref db="Reactome" id="R-DDI-73614" name="Pyrimidine salvage"/>
            <pathway-xref db="Reactome" id="R-SCE-8876198" name="RAB GEFs exchange GTP for GDP on RABs"/>
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            <pathway-xref db="MetaCyc" id="PWY-7859" name="jasmonoyl-L-isoleucine inactivation"/>
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            <pathway-xref db="Reactome" id="R-DRE-210993" name="Tie2 Signaling"/>
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            <pathway-xref db="Reactome" id="R-MMU-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-BTA-170968" name="Frs2-mediated activation"/>
            <pathway-xref db="Reactome" id="R-DRE-6811436" name="COPI-independent Golgi-to-ER retrograde traffic"/>
            <pathway-xref db="Reactome" id="R-HSA-5389840" name="Mitochondrial translation elongation"/>
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            <pathway-xref db="Reactome" id="R-MMU-5632684" name="Hedgehog 'on' state"/>
            <pathway-xref db="Reactome" id="R-BTA-380972" name="Energy dependent regulation of mTOR by LKB1-AMPK"/>
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            <pathway-xref db="MetaCyc" id="PWY-8083" name="domoic acid biosynthesis"/>
            <pathway-xref db="Reactome" id="R-GGA-9013424" name="RHOV GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-SPO-77075" name="RNA Pol II CTD phosphorylation and interaction with CE"/>
            <pathway-xref db="Reactome" id="R-DRE-674695" name="RNA Polymerase II Pre-transcription Events"/>
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            <pathway-xref db="Reactome" id="R-SSC-182971" name="EGFR downregulation"/>
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            <pathway-xref db="Reactome" id="R-DRE-209563" name="Axonal growth stimulation"/>
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            <pathway-xref db="Reactome" id="R-DDI-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-1632852" name="Macroautophagy"/>
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            <pathway-xref db="MetaCyc" id="PWY-5665" name="vanillin biosynthesis I"/>
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            <pathway-xref db="Reactome" id="R-MMU-2179392" name="EGFR Transactivation by Gastrin"/>
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            <pathway-xref db="Reactome" id="R-CFA-9706019" name="RHOBTB3 ATPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-8015" name="glycine degradation (reductive Stickland reaction)"/>
            <pathway-xref db="Reactome" id="R-DME-210500" name="Glutamate Neurotransmitter Release Cycle"/>
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            <pathway-xref db="Reactome" id="R-CEL-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DRE-171007" name="p38MAPK events"/>
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            <pathway-xref db="MetaCyc" id="PWY-5340" name="sulfate activation for sulfonation"/>
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            <pathway-xref db="Reactome" id="R-CEL-5205685" name="PINK1-PRKN Mediated Mitophagy"/>
            <pathway-xref db="Reactome" id="R-RNO-3928664" name="Ephrin signaling"/>
            <pathway-xref db="Reactome" id="R-GGA-354194" name="GRB2:SOS provides linkage to MAPK signaling for Integrins"/>
            <pathway-xref db="MetaCyc" id="PWY-8172" name="10-methylstearate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SCE-72662" name="Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S"/>
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            <pathway-xref db="MetaCyc" id="PWY-7687" name="stipitatate biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-DME-189451" name="Heme biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-6811436" name="COPI-independent Golgi-to-ER retrograde traffic"/>
            <pathway-xref db="Reactome" id="R-CFA-2565942" name="Regulation of PLK1 Activity at G2/M Transition"/>
            <pathway-xref db="Reactome" id="R-DDI-5673000" name="RAF activation"/>
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            <pathway-xref db="Reactome" id="R-HSA-2871837" name="FCERI mediated NF-kB activation"/>
            <pathway-xref db="Reactome" id="R-HSA-9646399" name="Aggrephagy"/>
            <pathway-xref db="Reactome" id="R-CEL-392517" name="Rap1 signalling"/>
            <pathway-xref db="MetaCyc" id="PWY-6930" name="phenolic malonylglucosides biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SPO-68884" name="Mitotic Telophase/Cytokinesis"/>
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            <pathway-xref db="Reactome" id="R-DRE-73772" name="RNA Polymerase I Promoter Escape"/>
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            <pathway-xref db="Reactome" id="R-CEL-9013424" name="RHOV GTPase cycle"/>
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            <pathway-xref db="Reactome" id="R-DME-8939243" name="RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"/>
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            <pathway-xref db="Reactome" id="R-MMU-203641" name="NOSTRIN mediated eNOS trafficking"/>
            <pathway-xref db="Reactome" id="R-CEL-2142850" name="Hyaluronan biosynthesis and export"/>
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            <pathway-xref db="MetaCyc" id="PWY-7807" name="glyphosate degradation III"/>
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            <pathway-xref db="Reactome" id="R-MMU-5693607" name="Processing of DNA double-strand break ends"/>
            <pathway-xref db="Reactome" id="R-MMU-72764" name="Eukaryotic Translation Termination"/>
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            <pathway-xref db="Reactome" id="R-SPO-196741" name="Cobalamin (Cbl, vitamin B12) transport and metabolism"/>
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            <pathway-xref db="MetaCyc" id="PWY-7354" name="aclacinomycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-392517" name="Rap1 signalling"/>
            <pathway-xref db="Reactome" id="R-HSA-72163" name="mRNA Splicing - Major Pathway"/>
            <pathway-xref db="Reactome" id="R-CFA-3928662" name="EPHB-mediated forward signaling"/>
            <pathway-xref db="Reactome" id="R-SSC-1169408" name="ISG15 antiviral mechanism"/>
            <pathway-xref db="Reactome" id="R-DDI-5358565" name="Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)"/>
            <pathway-xref db="Reactome" id="R-BTA-9639288" name="Amino acids regulate mTORC1"/>
            <pathway-xref db="Reactome" id="R-GGA-9013149" name="RAC1 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-7399" name="methylphosphonate degradation II"/>
            <pathway-xref db="Reactome" id="R-CEL-72165" name="mRNA Splicing - Minor Pathway"/>
            <pathway-xref db="Reactome" id="R-MMU-72706" name="GTP hydrolysis and joining of the 60S ribosomal subunit"/>
            <pathway-xref db="Reactome" id="R-RNO-983231" name="Factors involved in megakaryocyte development and platelet production"/>
            <pathway-xref db="Reactome" id="R-CEL-9013149" name="RAC1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-3769402" name="Deactivation of the beta-catenin transactivating complex"/>
            <pathway-xref db="Reactome" id="R-MMU-69481" name="G2/M Checkpoints"/>
            <pathway-xref db="Reactome" id="R-CEL-8949664" name="Processing of SMDT1"/>
            <pathway-xref db="Reactome" id="R-SPO-674695" name="RNA Polymerase II Pre-transcription Events"/>
            <pathway-xref db="MetaCyc" id="PWY-6920" name="6-gingerol analog biosynthesis (engineered)"/>
            <pathway-xref db="Reactome" id="R-DRE-3928662" name="EPHB-mediated forward signaling"/>
            <pathway-xref db="Reactome" id="R-DME-166208" name="mTORC1-mediated signalling"/>
            <pathway-xref db="MetaCyc" id="PWY-7988" name="baumannoferrin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DRE-1169408" name="ISG15 antiviral mechanism"/>
            <pathway-xref db="Reactome" id="R-SSC-5673001" name="RAF/MAP kinase cascade"/>
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            <pathway-xref db="Reactome" id="R-HSA-8951936" name="RUNX3 regulates p14-ARF"/>
            <pathway-xref db="Reactome" id="R-CEL-8849932" name="Synaptic adhesion-like molecules"/>
            <pathway-xref db="MetaCyc" id="PWY-7198" name="pyrimidine deoxyribonucleotides de novo biosynthesis IV"/>
            <pathway-xref db="Reactome" id="R-CFA-8856828" name="Clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-RNO-3928662" name="EPHB-mediated forward signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-1722" name="formate assimilation into 5,10-methylenetetrahydrofolate"/>
            <pathway-xref db="Reactome" id="R-SSC-5674135" name="MAP2K and MAPK activation"/>
            <pathway-xref db="Reactome" id="R-HSA-432040" name="Vasopressin regulates renal water homeostasis via Aquaporins"/>
            <pathway-xref db="Reactome" id="R-CEL-375165" name="NCAM signaling for neurite out-growth"/>
            <pathway-xref db="Reactome" id="R-MMU-983189" name="Kinesins"/>
            <pathway-xref db="Reactome" id="R-DRE-3769402" name="Deactivation of the beta-catenin transactivating complex"/>
            <pathway-xref db="Reactome" id="R-MMU-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-CEL-3108214" name="SUMOylation of DNA damage response and repair proteins"/>
            <pathway-xref db="Reactome" id="R-HSA-5358565" name="Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)"/>
            <pathway-xref db="Reactome" id="R-BTA-73614" name="Pyrimidine salvage"/>
            <pathway-xref db="Reactome" id="R-RNO-5676590" name="NIK--&gt;noncanonical NF-kB signaling"/>
            <pathway-xref db="Reactome" id="R-CEL-5687128" name="MAPK6/MAPK4 signaling"/>
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            <pathway-xref db="Reactome" id="R-RNO-171319" name="Telomere Extension By Telomerase"/>
            <pathway-xref db="Reactome" id="R-RNO-196807" name="Nicotinate metabolism"/>
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          <signature-library-release library="GENE3D" version="4.3.0"/>
        </signature>
        <model-ac>2xzoA03</model-ac>
        <locations>
          <hmmer3-location env-end="1901" env-start="1704" post-processed="true" score="103.2" evalue="4.4E-29" hmm-start="50" hmm-end="193" hmm-length="213" hmm-bounds="COMPLETE" start="1704" end="1901">
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              <hmmer3-location-fragment start="1704" end="1901" dc-status="CONTINUOUS"/>
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        </locations>
      </hmmer3-match>
      <hmmer3-match evalue="1.9E-51" score="163.9">
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            <pathway-xref db="Reactome" id="R-MMU-6791226" name="Major pathway of rRNA processing in the nucleolus and cytosol"/>
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            <pathway-xref db="Reactome" id="R-SCE-110312" name="Translesion synthesis by REV1"/>
            <pathway-xref db="Reactome" id="R-HSA-2559586" name="DNA Damage/Telomere Stress Induced Senescence"/>
            <pathway-xref db="Reactome" id="R-GGA-5696400" name="Dual Incision in GG-NER"/>
            <pathway-xref db="MetaCyc" id="PWY-7177" name="UTP and CTP dephosphorylation II"/>
            <pathway-xref db="Reactome" id="R-HSA-5693616" name="Presynaptic phase of homologous DNA pairing and strand exchange"/>
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            <pathway-xref db="MetaCyc" id="PWY-7631" name="arctigenin and isoarctigenin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-209461" name="Ubiquitination and degradation of phosphorylated ARM"/>
            <pathway-xref db="Reactome" id="R-RNO-525793" name="Myogenesis"/>
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            <pathway-xref db="Reactome" id="R-SSC-8951664" name="Neddylation"/>
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            <pathway-xref db="Reactome" id="R-DME-9668328" name="Sealing of the nuclear envelope (NE) by ESCRT-III"/>
            <pathway-xref db="Reactome" id="R-SPO-8856828" name="Clathrin-mediated endocytosis"/>
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            <pathway-xref db="Reactome" id="R-HSA-156902" name="Peptide chain elongation"/>
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            <pathway-xref db="Reactome" id="R-HSA-5578775" name="Ion homeostasis"/>
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            <pathway-xref db="Reactome" id="R-MMU-2132295" name="MHC class II antigen presentation"/>
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            <pathway-xref db="Reactome" id="R-GGA-392517" name="Rap1 signalling"/>
            <pathway-xref db="Reactome" id="R-SSC-179812" name="GRB2 events in EGFR signaling"/>
            <pathway-xref db="Reactome" id="R-DME-75955" name="RNA Polymerase II Transcription Elongation"/>
            <pathway-xref db="Reactome" id="R-GGA-5218921" name="VEGFR2 mediated cell proliferation"/>
            <pathway-xref db="Reactome" id="R-DRE-5696400" name="Dual Incision in GG-NER"/>
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            <pathway-xref db="Reactome" id="R-SPO-68962" name="Activation of the pre-replicative complex"/>
            <pathway-xref db="Reactome" id="R-GGA-182971" name="EGFR downregulation"/>
            <pathway-xref db="Reactome" id="R-RNO-5218921" name="VEGFR2 mediated cell proliferation"/>
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            <pathway-xref db="Reactome" id="R-HSA-9679191" name="Potential therapeutics for SARS"/>
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            <pathway-xref db="Reactome" id="R-DRE-390247" name="Beta-oxidation of very long chain fatty acids"/>
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            <pathway-xref db="MetaCyc" id="PWY-7752" name="gadusol biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-7950" name="diadinoxanthin and fucoxanthin biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-SPO-9013425" name="RHOT1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-BTA-110320" name="Translesion Synthesis by POLH"/>
            <pathway-xref db="Reactome" id="R-XTR-381676" name="Glucagon-like Peptide-1 (GLP1) regulates insulin secretion"/>
            <pathway-xref db="Reactome" id="R-DRE-416572" name="Sema4D induced cell migration and growth-cone collapse"/>
            <pathway-xref db="Reactome" id="R-DDI-1632852" name="Macroautophagy"/>
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            <pathway-xref db="Reactome" id="R-DDI-174113" name="SCF-beta-TrCP mediated degradation of Emi1"/>
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            <pathway-xref db="MetaCyc" id="PWY-8257" name="Escherichia coli serotype O:52 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-5651801" name="PCNA-Dependent Long Patch Base Excision Repair"/>
            <pathway-xref db="MetaCyc" id="PWY-5475" name="pentagalloylglucose biosynthesis"/>
            <pathway-xref db="Reactome" id="R-BTA-9013408" name="RHOG GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-375165" name="NCAM signaling for neurite out-growth"/>
            <pathway-xref db="MetaCyc" id="PWY-7733" name="3-hydroxyquinaldate biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-SCE-8964058" name="HDL remodeling"/>
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            <pathway-xref db="Reactome" id="R-SCE-9013026" name="RHOB GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-5683371" name="Defective ABCB6 causes MCOPCB7"/>
            <pathway-xref db="MetaCyc" id="PWY-7669" name="equisetin biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-MMU-380259" name="Loss of Nlp from mitotic centrosomes"/>
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            <pathway-xref db="Reactome" id="R-MMU-8876198" name="RAB GEFs exchange GTP for GDP on RABs"/>
            <pathway-xref db="MetaCyc" id="PWY-7659" name="viridicatumtoxin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-84" name="resveratrol biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-HSA-166016" name="Toll Like Receptor 4 (TLR4) Cascade"/>
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            <pathway-xref db="Reactome" id="R-DDI-159418" name="Recycling of bile acids and salts"/>
            <pathway-xref db="MetaCyc" id="PWY-8250" name="Escherichia coli serotype O:9 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-182971" name="EGFR downregulation"/>
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            <pathway-xref db="Reactome" id="R-SCE-983231" name="Factors involved in megakaryocyte development and platelet production"/>
            <pathway-xref db="Reactome" id="R-SPO-73614" name="Pyrimidine salvage"/>
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            <pathway-xref db="Reactome" id="R-GGA-68827" name="CDT1 association with the CDC6:ORC:origin complex"/>
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            <pathway-xref db="Reactome" id="R-MMU-75153" name="Apoptotic execution phase"/>
            <pathway-xref db="MetaCyc" id="PWY-6613" name="tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate"/>
            <pathway-xref db="Reactome" id="R-MMU-4608870" name="Asymmetric localization of PCP proteins"/>
            <pathway-xref db="Reactome" id="R-HSA-844456" name="The NLRP3 inflammasome"/>
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            <pathway-xref db="Reactome" id="R-SPO-9013419" name="RHOT2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DME-429947" name="Deadenylation of mRNA"/>
            <pathway-xref db="Reactome" id="R-DME-68867" name="Assembly of the pre-replicative complex"/>
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            <pathway-xref db="MetaCyc" id="PWY-8045" name="cylindrospermopsin biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-7342" name="superpathway of nicotine biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-DDI-9013425" name="RHOT1 GTPase cycle"/>
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            <pathway-xref db="Reactome" id="R-MMU-525793" name="Myogenesis"/>
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            <pathway-xref db="Reactome" id="R-CEL-110320" name="Translesion Synthesis by POLH"/>
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            <pathway-xref db="Reactome" id="R-RNO-5651801" name="PCNA-Dependent Long Patch Base Excision Repair"/>
            <pathway-xref db="MetaCyc" id="PWY-81" name="toluene degradation to benzoyl-CoA (anaerobic)"/>
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            <pathway-xref db="Reactome" id="R-RNO-4641257" name="Degradation of AXIN"/>
            <pathway-xref db="Reactome" id="R-MMU-2022870" name="Chondroitin sulfate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7232" name="gibberellin biosynthesis V"/>
            <pathway-xref db="Reactome" id="R-CEL-8849471" name="PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases"/>
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            <pathway-xref db="Reactome" id="R-MMU-8932339" name="ROS sensing by NFE2L2"/>
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            <pathway-xref db="Reactome" id="R-RNO-5689901" name="Metalloprotease DUBs"/>
            <pathway-xref db="MetaCyc" id="PWY-7693" name="guadinomine B biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-MMU-9013418" name="RHOBTB2 GTPase cycle"/>
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            <pathway-xref db="Reactome" id="R-DME-6804758" name="Regulation of TP53 Activity through Acetylation"/>
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            <pathway-xref db="Reactome" id="R-DME-350368" name="Activation of RHO1 by FZ:DSH complex"/>
            <pathway-xref db="Reactome" id="R-DME-451308" name="Activation of Ca-permeable Kainate Receptor"/>
            <pathway-xref db="Reactome" id="R-HSA-4551638" name="SUMOylation of chromatin organization proteins"/>
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            <pathway-xref db="Reactome" id="R-MMU-354194" name="GRB2:SOS provides linkage to MAPK signaling for Integrins"/>
            <pathway-xref db="MetaCyc" id="PWY-7563" name="bassianin and desmethylbassianin biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-MMU-5696394" name="DNA Damage Recognition in GG-NER"/>
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            <pathway-xref db="Reactome" id="R-SPO-8873719" name="RAB geranylgeranylation"/>
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            <pathway-xref db="MetaCyc" id="PWY-2161" name="folate polyglutamylation"/>
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            <pathway-xref db="MetaCyc" id="PWY-7222" name="guanosine deoxyribonucleotides de novo biosynthesis II"/>
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            <pathway-xref db="Reactome" id="R-GGA-68689" name="CDC6 association with the ORC:origin complex"/>
            <pathway-xref db="Reactome" id="R-MMU-8964058" name="HDL remodeling"/>
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            <pathway-xref db="Reactome" id="R-CEL-4420097" name="VEGFA-VEGFR2 Pathway"/>
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            <pathway-xref db="Reactome" id="R-RNO-5656121" name="Translesion synthesis by POLI"/>
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            <pathway-xref db="Reactome" id="R-SCE-983189" name="Kinesins"/>
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            <pathway-xref db="Reactome" id="R-HSA-9682706" name="Replication of the SARS-CoV-1 genome"/>
            <pathway-xref db="Reactome" id="R-CFA-9013408" name="RHOG GTPase cycle"/>
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            <pathway-xref db="Reactome" id="R-RNO-888590" name="GABA synthesis, release, reuptake and degradation"/>
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            <pathway-xref db="Reactome" id="R-SPO-434316" name="Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion"/>
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            <pathway-xref db="Reactome" id="R-RNO-399719" name="Trafficking of AMPA receptors"/>
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            <pathway-xref db="Reactome" id="R-CFA-9013148" name="CDC42 GTPase cycle"/>
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            <pathway-xref db="Reactome" id="R-MMU-9013406" name="RHOQ GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-SPO-159236" name="Transport of Mature mRNA derived from an Intron-Containing Transcript"/>
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            <pathway-xref db="Reactome" id="R-DRE-5620924" name="Intraflagellar transport"/>
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            <pathway-xref db="Reactome" id="R-BTA-199992" name="trans-Golgi Network Vesicle Budding"/>
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            <pathway-xref db="Reactome" id="R-HSA-112308" name="Presynaptic depolarization and calcium channel opening"/>
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            <pathway-xref db="Reactome" id="R-SSC-182971" name="EGFR downregulation"/>
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            <pathway-xref db="Reactome" id="R-GGA-114604" name="GPVI-mediated activation cascade"/>
            <pathway-xref db="Reactome" id="R-MMU-8876725" name="Protein methylation"/>
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            <pathway-xref db="MetaCyc" id="PWY-7805" name="(aminomethyl)phosphonate degradation"/>
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            <pathway-xref db="Reactome" id="R-DME-69091" name="Polymerase switching"/>
            <pathway-xref db="MetaCyc" id="PWY-8086" name="(S)-lactate fermentation to propanoate, acetate and hydrogen"/>
            <pathway-xref db="Reactome" id="R-MMU-170984" name="ARMS-mediated activation"/>
            <pathway-xref db="Reactome" id="R-DRE-156827" name="L13a-mediated translational silencing of Ceruloplasmin expression"/>
            <pathway-xref db="Reactome" id="R-RNO-381042" name="PERK regulates gene expression"/>
            <pathway-xref db="Reactome" id="R-MMU-416476" name="G alpha (q) signalling events"/>
            <pathway-xref db="Reactome" id="R-MMU-68827" name="CDT1 association with the CDC6:ORC:origin complex"/>
            <pathway-xref db="Reactome" id="R-DRE-392517" name="Rap1 signalling"/>
            <pathway-xref db="Reactome" id="R-BTA-3134963" name="DEx/H-box helicases activate type I IFN and inflammatory cytokines production"/>
            <pathway-xref db="Reactome" id="R-HSA-9670613" name="Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations"/>
            <pathway-xref db="MetaCyc" id="PWY-5313" name="superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)"/>
            <pathway-xref db="Reactome" id="R-MMU-8875656" name="MET receptor recycling"/>
            <pathway-xref db="Reactome" id="R-CFA-5620916" name="VxPx cargo-targeting to cilium"/>
            <pathway-xref db="Reactome" id="R-DME-69601" name="Ubiquitin Mediated Degradation of Phosphorylated Cdc25A"/>
            <pathway-xref db="Reactome" id="R-SCE-1222556" name="ROS and RNS production in phagocytes"/>
            <pathway-xref db="Reactome" id="R-MMU-399954" name="Sema3A PAK dependent Axon repulsion"/>
            <pathway-xref db="Reactome" id="R-RNO-975957" name="Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"/>
            <pathway-xref db="Reactome" id="R-SSC-5620916" name="VxPx cargo-targeting to cilium"/>
            <pathway-xref db="Reactome" id="R-SSC-5607761" name="Dectin-1 mediated noncanonical NF-kB signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-176974" name="Unwinding of DNA"/>
            <pathway-xref db="MetaCyc" id="PWY-7029" name="terminal olefins biosynthesis II"/>
            <pathway-xref db="Reactome" id="R-DME-72695" name="Formation of the ternary complex, and subsequently, the 43S complex"/>
            <pathway-xref db="Reactome" id="R-MMU-2046106" name="alpha-linolenic acid (ALA) metabolism"/>
            <pathway-xref db="Reactome" id="R-MMU-9035034" name="RHOF GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-6736" name="sulfur volatiles biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DDI-5358606" name="Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)"/>
            <pathway-xref db="Reactome" id="R-HSA-8876198" name="RAB GEFs exchange GTP for GDP on RABs"/>
            <pathway-xref db="Reactome" id="R-RNO-5685939" name="HDR through MMEJ (alt-NHEJ)"/>
            <pathway-xref db="Reactome" id="R-MMU-392170" name="ADP signalling through P2Y purinoceptor 12"/>
            <pathway-xref db="MetaCyc" id="PWY-7150" name="polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)"/>
            <pathway-xref db="Reactome" id="R-MMU-418597" name="G alpha (z) signalling events"/>
            <pathway-xref db="Reactome" id="R-SSC-5676590" name="NIK--&gt;noncanonical NF-kB signaling"/>
            <pathway-xref db="Reactome" id="R-DRE-3270619" name="IRF3-mediated induction of type I IFN"/>
            <pathway-xref db="Reactome" id="R-SPO-1799339" name="SRP-dependent cotranslational protein targeting to membrane"/>
            <pathway-xref db="MetaCyc" id="PWY-5139" name="pelargonidin conjugates biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7151" name="polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)"/>
            <pathway-xref db="Reactome" id="R-HSA-9673767" name="Signaling by PDGFRA transmembrane, juxtamembrane and kinase domain mutants"/>
            <pathway-xref db="Reactome" id="R-CFA-9009391" name="Extra-nuclear estrogen signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-983231" name="Factors involved in megakaryocyte development and platelet production"/>
            <pathway-xref db="Reactome" id="R-DME-418594" name="G alpha (i) signalling events"/>
            <pathway-xref db="MetaCyc" id="PWY-5477" name="gallotannin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-110320" name="Translesion Synthesis by POLH"/>
            <pathway-xref db="Reactome" id="R-MMU-111469" name="SMAC, XIAP-regulated apoptotic response"/>
            <pathway-xref db="Reactome" id="R-MMU-9013425" name="RHOT1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-2514859" name="Inactivation, recovery and regulation of the phototransduction cascade"/>
            <pathway-xref db="Reactome" id="R-DME-2173791" name="TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)"/>
            <pathway-xref db="Reactome" id="R-RNO-5673001" name="RAF/MAP kinase cascade"/>
            <pathway-xref db="Reactome" id="R-DDI-1660516" name="Synthesis of PIPs at the early endosome membrane"/>
            <pathway-xref db="Reactome" id="R-CEL-4086398" name="Ca2+ pathway"/>
            <pathway-xref db="Reactome" id="R-MTU-964903" name="Chorismate via Shikimate Pathway"/>
            <pathway-xref db="MetaCyc" id="PWY-6679" name="jadomycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-6783310" name="Fanconi Anemia Pathway"/>
            <pathway-xref db="Reactome" id="R-HSA-381042" name="PERK regulates gene expression"/>
            <pathway-xref db="Reactome" id="R-DME-5419276" name="Mitochondrial translation termination"/>
            <pathway-xref db="Reactome" id="R-RNO-5674135" name="MAP2K and MAPK activation"/>
            <pathway-xref db="MetaCyc" id="PWY-5482" name="pyruvate fermentation to acetate II"/>
            <pathway-xref db="Reactome" id="R-DRE-9013106" name="RHOC GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-GGA-5656169" name="Termination of translesion DNA synthesis"/>
            <pathway-xref db="Reactome" id="R-DME-390247" name="Beta-oxidation of very long chain fatty acids"/>
            <pathway-xref db="Reactome" id="R-HSA-5620922" name="BBSome-mediated cargo-targeting to cilium"/>
            <pathway-xref db="MetaCyc" id="PWY-6971" name="oleandomycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-156842" name="Eukaryotic Translation Elongation"/>
            <pathway-xref db="Reactome" id="R-HSA-72731" name="Recycling of eIF2:GDP"/>
            <pathway-xref db="Reactome" id="R-DRE-392451" name="G beta:gamma signalling through PI3Kgamma"/>
            <pathway-xref db="Reactome" id="R-DRE-156584" name="Cytosolic sulfonation of small molecules"/>
            <pathway-xref db="Reactome" id="R-CFA-9013106" name="RHOC GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-8098" name="cyclic 2,3-bisphosphoglycerate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-203641" name="NOSTRIN mediated eNOS trafficking"/>
            <pathway-xref db="Reactome" id="R-CEL-2142850" name="Hyaluronan biosynthesis and export"/>
            <pathway-xref db="Reactome" id="R-HSA-5627083" name="RHO GTPases regulate CFTR trafficking"/>
            <pathway-xref db="Reactome" id="R-SPO-8876198" name="RAB GEFs exchange GTP for GDP on RABs"/>
            <pathway-xref db="Reactome" id="R-RNO-5607761" name="Dectin-1 mediated noncanonical NF-kB signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-5679090" name="Defective ABCG8 causes GBD4 and sitosterolemia"/>
            <pathway-xref db="Reactome" id="R-BTA-8849471" name="PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases"/>
            <pathway-xref db="Reactome" id="R-DRE-5673001" name="RAF/MAP kinase cascade"/>
            <pathway-xref db="Reactome" id="R-SPO-5358565" name="Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)"/>
            <pathway-xref db="Reactome" id="R-HSA-191650" name="Regulation of gap junction activity"/>
            <pathway-xref db="Reactome" id="R-HSA-167162" name="RNA Polymerase II HIV Promoter Escape"/>
            <pathway-xref db="Reactome" id="R-RNO-428930" name="Thromboxane signalling through TP receptor"/>
            <pathway-xref db="Reactome" id="R-RNO-9009391" name="Extra-nuclear estrogen signaling"/>
            <pathway-xref db="Reactome" id="R-DME-8873719" name="RAB geranylgeranylation"/>
            <pathway-xref db="Reactome" id="R-HSA-6804758" name="Regulation of TP53 Activity through Acetylation"/>
            <pathway-xref db="Reactome" id="R-HSA-68884" name="Mitotic Telophase/Cytokinesis"/>
            <pathway-xref db="Reactome" id="R-SCE-917977" name="Transferrin endocytosis and recycling"/>
            <pathway-xref db="MetaCyc" id="PWY-8055" name="palmitoyl ethanolamide biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7807" name="glyphosate degradation III"/>
            <pathway-xref db="Reactome" id="R-RNO-5620916" name="VxPx cargo-targeting to cilium"/>
            <pathway-xref db="Reactome" id="R-MMU-5693607" name="Processing of DNA double-strand break ends"/>
            <pathway-xref db="Reactome" id="R-MMU-72764" name="Eukaryotic Translation Termination"/>
            <pathway-xref db="Reactome" id="R-DME-5693616" name="Presynaptic phase of homologous DNA pairing and strand exchange"/>
            <pathway-xref db="Reactome" id="R-BTA-9035034" name="RHOF GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-SPO-5620912" name="Anchoring of the basal body to the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-SPO-196741" name="Cobalamin (Cbl, vitamin B12) transport and metabolism"/>
            <pathway-xref db="Reactome" id="R-MMU-2424491" name="DAP12 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-7354" name="aclacinomycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-392517" name="Rap1 signalling"/>
            <pathway-xref db="Reactome" id="R-HSA-72163" name="mRNA Splicing - Major Pathway"/>
            <pathway-xref db="Reactome" id="R-CFA-3928662" name="EPHB-mediated forward signaling"/>
            <pathway-xref db="Reactome" id="R-SSC-1169408" name="ISG15 antiviral mechanism"/>
            <pathway-xref db="Reactome" id="R-DDI-5358565" name="Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)"/>
            <pathway-xref db="Reactome" id="R-BTA-9639288" name="Amino acids regulate mTORC1"/>
            <pathway-xref db="Reactome" id="R-GGA-9013149" name="RAC1 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-7399" name="methylphosphonate degradation II"/>
            <pathway-xref db="Reactome" id="R-CEL-72165" name="mRNA Splicing - Minor Pathway"/>
            <pathway-xref db="Reactome" id="R-MMU-72706" name="GTP hydrolysis and joining of the 60S ribosomal subunit"/>
            <pathway-xref db="Reactome" id="R-RNO-983231" name="Factors involved in megakaryocyte development and platelet production"/>
            <pathway-xref db="Reactome" id="R-CEL-9013149" name="RAC1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-3769402" name="Deactivation of the beta-catenin transactivating complex"/>
            <pathway-xref db="Reactome" id="R-MMU-69481" name="G2/M Checkpoints"/>
            <pathway-xref db="Reactome" id="R-CEL-8949664" name="Processing of SMDT1"/>
            <pathway-xref db="Reactome" id="R-SPO-674695" name="RNA Polymerase II Pre-transcription Events"/>
            <pathway-xref db="MetaCyc" id="PWY-6920" name="6-gingerol analog biosynthesis (engineered)"/>
            <pathway-xref db="Reactome" id="R-DRE-3928662" name="EPHB-mediated forward signaling"/>
            <pathway-xref db="Reactome" id="R-DME-166208" name="mTORC1-mediated signalling"/>
            <pathway-xref db="MetaCyc" id="PWY-7988" name="baumannoferrin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DRE-1169408" name="ISG15 antiviral mechanism"/>
            <pathway-xref db="Reactome" id="R-SSC-5673001" name="RAF/MAP kinase cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-8951664" name="Neddylation"/>
            <pathway-xref db="Reactome" id="R-HSA-8951936" name="RUNX3 regulates p14-ARF"/>
            <pathway-xref db="Reactome" id="R-CEL-8849932" name="Synaptic adhesion-like molecules"/>
            <pathway-xref db="MetaCyc" id="PWY-7198" name="pyrimidine deoxyribonucleotides de novo biosynthesis IV"/>
            <pathway-xref db="Reactome" id="R-CFA-8856828" name="Clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-RNO-3928662" name="EPHB-mediated forward signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-1722" name="formate assimilation into 5,10-methylenetetrahydrofolate"/>
            <pathway-xref db="Reactome" id="R-SSC-5674135" name="MAP2K and MAPK activation"/>
            <pathway-xref db="Reactome" id="R-HSA-432040" name="Vasopressin regulates renal water homeostasis via Aquaporins"/>
            <pathway-xref db="Reactome" id="R-CEL-375165" name="NCAM signaling for neurite out-growth"/>
            <pathway-xref db="Reactome" id="R-MMU-983189" name="Kinesins"/>
            <pathway-xref db="Reactome" id="R-DRE-3769402" name="Deactivation of the beta-catenin transactivating complex"/>
            <pathway-xref db="Reactome" id="R-MMU-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-CEL-3108214" name="SUMOylation of DNA damage response and repair proteins"/>
            <pathway-xref db="Reactome" id="R-HSA-5358565" name="Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)"/>
            <pathway-xref db="Reactome" id="R-BTA-73614" name="Pyrimidine salvage"/>
            <pathway-xref db="Reactome" id="R-RNO-5676590" name="NIK--&gt;noncanonical NF-kB signaling"/>
            <pathway-xref db="Reactome" id="R-CEL-5687128" name="MAPK6/MAPK4 signaling"/>
            <pathway-xref db="Reactome" id="R-DME-190873" name="Gap junction degradation"/>
            <pathway-xref db="Reactome" id="R-RNO-171319" name="Telomere Extension By Telomerase"/>
            <pathway-xref db="Reactome" id="R-RNO-196807" name="Nicotinate metabolism"/>
            <pathway-xref db="Reactome" id="R-HSA-77075" name="RNA Pol II CTD phosphorylation and interaction with CE"/>
            <pathway-xref db="Reactome" id="R-SSC-8851805" name="MET activates RAS signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-8301" name="S-(6-hydroxy-4-methylhexan-4-yl)-L-cysteinylglycine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-5694530" name="Cargo concentration in the ER"/>
            <pathway-xref db="Reactome" id="R-SCE-8856828" name="Clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-RNO-73863" name="RNA Polymerase I Transcription Termination"/>
            <pathway-xref db="Reactome" id="R-RNO-9013106" name="RHOC GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-8875555" name="MET activates RAP1 and RAC1"/>
            <pathway-xref db="Reactome" id="R-RNO-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-SPO-2514853" name="Condensation of Prometaphase Chromosomes"/>
            <pathway-xref db="Reactome" id="R-DME-426486" name="Small interfering RNA (siRNA) biogenesis"/>
            <pathway-xref db="Reactome" id="R-DRE-5674135" name="MAP2K and MAPK activation"/>
            <pathway-xref db="Reactome" id="R-RNO-1169408" name="ISG15 antiviral mechanism"/>
            <pathway-xref db="Reactome" id="R-MMU-72165" name="mRNA Splicing - Minor Pathway"/>
            <pathway-xref db="Reactome" id="R-MMU-418555" name="G alpha (s) signalling events"/>
            <pathway-xref db="Reactome" id="R-CEL-9634635" name="Estrogen-stimulated signaling through PRKCZ"/>
          </entry>
          <signature-library-release library="GENE3D" version="4.3.0"/>
        </signature>
        <model-ac>4b3fX01</model-ac>
        <locations>
          <hmmer3-location env-end="0" env-start="0" post-processed="true" score="163.9" evalue="2.1E-47" hmm-start="0" hmm-end="0" hmm-length="331" hmm-bounds="INCOMPLETE" start="1316" end="1697">
            <location-fragments>
              <hmmer3-location-fragment start="1316" end="1465" dc-status="C_TERMINAL_DISC"/>
              <hmmer3-location-fragment start="1521" end="1697" dc-status="N_TERMINAL_DISC"/>
            </location-fragments>
          </hmmer3-location>
        </locations>
      </hmmer3-match>
      <hmmer3-match evalue="1.2E-299" score="996.0">
        <signature ac="PF16399" desc="Intron-binding protein aquarius N-terminus" name="Aquarius_N">
          <entry ac="IPR032174" desc="Intron-binding protein aquarius, N-terminal" name="Aquarius_N" type="DOMAIN">
            <pathway-xref db="Reactome" id="R-MMU-6781823" name="Formation of TC-NER Pre-Incision Complex"/>
            <pathway-xref db="Reactome" id="R-HSA-6782210" name="Gap-filling DNA repair synthesis and ligation in TC-NER"/>
            <pathway-xref db="Reactome" id="R-MMU-6782135" name="Dual incision in TC-NER"/>
            <pathway-xref db="Reactome" id="R-MMU-72163" name="mRNA Splicing - Major Pathway"/>
            <pathway-xref db="Reactome" id="R-HSA-6781827" name="Transcription-Coupled Nucleotide Excision Repair (TC-NER)"/>
            <pathway-xref db="Reactome" id="R-HSA-6781823" name="Formation of TC-NER Pre-Incision Complex"/>
            <pathway-xref db="Reactome" id="R-HSA-6782135" name="Dual incision in TC-NER"/>
            <pathway-xref db="Reactome" id="R-MMU-6782210" name="Gap-filling DNA repair synthesis and ligation in TC-NER"/>
            <pathway-xref db="Reactome" id="R-HSA-72163" name="mRNA Splicing - Major Pathway"/>
          </entry>
          <signature-library-release library="PFAM" version="34.0"/>
        </signature>
        <model-ac>PF16399</model-ac>
        <locations>
          <hmmer3-location env-end="1367" env-start="591" post-processed="true" score="995.6" evalue="1.6E-299" hmm-start="1" hmm-end="798" hmm-length="798" hmm-bounds="COMPLETE" start="591" end="1367">
            <location-fragments>
              <hmmer3-location-fragment start="591" end="1367" dc-status="CONTINUOUS"/>
            </location-fragments>
          </hmmer3-location>
        </locations>
      </hmmer3-match>
      <hmmer3-match evalue="8.2E-116" score="387.8">
        <signature ac="PF07093" desc="SGT1 protein" name="SGT1">
          <entry ac="IPR010770" desc="Ecd family" name="Ecd" type="FAMILY"/>
          <signature-library-release library="PFAM" version="34.0"/>
        </signature>
        <model-ac>PF07093</model-ac>
        <locations>
          <hmmer3-location env-end="551" env-start="13" post-processed="true" score="386.6" evalue="1.8E-115" hmm-start="1" hmm-end="523" hmm-length="583" hmm-bounds="N_TERMINAL_COMPLETE" start="13" end="514">
            <location-fragments>
              <hmmer3-location-fragment start="13" end="514" dc-status="CONTINUOUS"/>
            </location-fragments>
          </hmmer3-location>
        </locations>
      </hmmer3-match>
      <mobidblite-match>
        <signature ac="mobidb-lite" desc="consensus disorder prediction" name="disorder_prediction">
          <signature-library-release library="MOBIDB_LITE" version="2.0"/>
        </signature>
        <model-ac>mobidb-lite</model-ac>
        <locations>
          <mobidblite-location sequence-feature="Polyampholyte" start="483" end="520">
            <location-fragments>
              <mobidblite-location-fragment start="483" end="520" dc-status="CONTINUOUS"/>
            </location-fragments>
          </mobidblite-location>
        </locations>
      </mobidblite-match>
      <mobidblite-match>
        <signature ac="mobidb-lite" desc="consensus disorder prediction" name="disorder_prediction">
          <signature-library-release library="MOBIDB_LITE" version="2.0"/>
        </signature>
        <model-ac>mobidb-lite</model-ac>
        <locations>
          <mobidblite-location sequence-feature="Polyampholyte" start="530" end="569">
            <location-fragments>
              <mobidblite-location-fragment start="530" end="569" dc-status="CONTINUOUS"/>
            </location-fragments>
          </mobidblite-location>
        </locations>
      </mobidblite-match>
      <mobidblite-match>
        <signature ac="mobidb-lite" desc="consensus disorder prediction" name="disorder_prediction">
          <signature-library-release library="MOBIDB_LITE" version="2.0"/>
        </signature>
        <model-ac>mobidb-lite</model-ac>
        <locations>
          <mobidblite-location sequence-feature="Polar" start="570" end="591">
            <location-fragments>
              <mobidblite-location-fragment start="570" end="591" dc-status="CONTINUOUS"/>
            </location-fragments>
          </mobidblite-location>
        </locations>
      </mobidblite-match>
      <mobidblite-match>
        <signature ac="mobidb-lite" desc="consensus disorder prediction" name="disorder_prediction">
          <signature-library-release library="MOBIDB_LITE" version="2.0"/>
        </signature>
        <model-ac>mobidb-lite</model-ac>
        <locations>
          <mobidblite-location sequence-feature="Polyampholyte" start="1967" end="1986">
            <location-fragments>
              <mobidblite-location-fragment start="1967" end="1986" dc-status="CONTINUOUS"/>
            </location-fragments>
          </mobidblite-location>
        </locations>
      </mobidblite-match>
      <mobidblite-match>
        <signature ac="mobidb-lite" desc="consensus disorder prediction" name="disorder_prediction">
          <signature-library-release library="MOBIDB_LITE" version="2.0"/>
        </signature>
        <model-ac>mobidb-lite</model-ac>
        <locations>
          <mobidblite-location sequence-feature="" start="1946" end="1999">
            <location-fragments>
              <mobidblite-location-fragment start="1946" end="1999" dc-status="CONTINUOUS"/>
            </location-fragments>
          </mobidblite-location>
        </locations>
      </mobidblite-match>
      <mobidblite-match>
        <signature ac="mobidb-lite" desc="consensus disorder prediction" name="disorder_prediction">
          <signature-library-release library="MOBIDB_LITE" version="2.0"/>
        </signature>
        <model-ac>mobidb-lite</model-ac>
        <locations>
          <mobidblite-location sequence-feature="" start="479" end="591">
            <location-fragments>
              <mobidblite-location-fragment start="479" end="591" dc-status="CONTINUOUS"/>
            </location-fragments>
          </mobidblite-location>
        </locations>
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            <pathway-xref db="MetaCyc" id="PWY-6795" name="diacylglyceryl-N,N,N-trimethylhomoserine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-69166" name="Removal of the Flap Intermediate"/>
            <pathway-xref db="MetaCyc" id="PWY-7765" name="3-hydroxy-4-methyl-anthranilate biosynthesis II"/>
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            <pathway-xref db="Reactome" id="R-HSA-400206" name="Regulation of lipid metabolism by PPARalpha"/>
            <pathway-xref db="MetaCyc" id="PWY-7155" name="7-dehydroporiferasterol biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-7739" name="aucuparin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5059" name="pinobanksin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7745" name="p-HBAD biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-7614" name="methiin metabolism"/>
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            <pathway-xref db="MetaCyc" id="PWY-7668" name="apicidin F biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-7534" name="gliotoxin inactivation"/>
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            <pathway-xref db="MetaCyc" id="PWY-6148" name="tetrahydromethanopterin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9707564" name="Cytoprotection by HMOX1"/>
            <pathway-xref db="MetaCyc" id="PWY-601" name="glucosinolate biosynthesis from tryptophan"/>
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            <pathway-xref db="MetaCyc" id="PWY-7692" name="bikaverin biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-7186" name="superpathway of scopolin and esculin biosynthesis"/>
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        </signature>
        <model-ac>cd18808</model-ac>
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            <pathway-xref db="Reactome" id="R-DME-983170" name="Antigen Presentation: Folding, assembly and peptide loading of class I MHC"/>
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            <pathway-xref db="Reactome" id="R-BTA-5620922" name="BBSome-mediated cargo-targeting to cilium"/>
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            <pathway-xref db="Reactome" id="R-BTA-110320" name="Translesion Synthesis by POLH"/>
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            <pathway-xref db="Reactome" id="R-RNO-1257604" name="PIP3 activates AKT signaling"/>
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            <pathway-xref db="MetaCyc" id="PWY-5475" name="pentagalloylglucose biosynthesis"/>
            <pathway-xref db="Reactome" id="R-BTA-9013408" name="RHOG GTPase cycle"/>
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            <pathway-xref db="Reactome" id="R-SPO-8876725" name="Protein methylation"/>
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            <pathway-xref db="Reactome" id="R-SSC-2179392" name="EGFR Transactivation by Gastrin"/>
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            <pathway-xref db="Reactome" id="R-SCE-9013026" name="RHOB GTPase cycle"/>
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            <pathway-xref db="Reactome" id="R-SCE-189451" name="Heme biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-CFA-9013026" name="RHOB GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-9694271" name="Assembly of the SARS-CoV-2 Replication-Transcription Complex (RTC)"/>
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            <pathway-xref db="Reactome" id="R-CFA-162658" name="Golgi Cisternae Pericentriolar Stack Reorganization"/>
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            <pathway-xref db="Reactome" id="R-GGA-5654688" name="SHC-mediated cascade:FGFR1"/>
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            <pathway-xref db="MetaCyc" id="PWY-6613" name="tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate"/>
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            <pathway-xref db="Reactome" id="R-DME-68867" name="Assembly of the pre-replicative complex"/>
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            <pathway-xref db="Reactome" id="R-DME-9009391" name="Extra-nuclear estrogen signaling"/>
            <pathway-xref db="Reactome" id="R-DME-375165" name="NCAM signaling for neurite out-growth"/>
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            <pathway-xref db="Reactome" id="R-DDI-9013407" name="RHOH GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-69473" name="G2/M DNA damage checkpoint"/>
            <pathway-xref db="MetaCyc" id="PWY-7740" name="beta-D-mannosyl phosphomycoketide biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-CEL-110314" name="Recognition of DNA damage by PCNA-containing replication complex"/>
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            <pathway-xref db="Reactome" id="R-DRE-75953" name="RNA Polymerase II Transcription Initiation"/>
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            <pathway-xref db="MetaCyc" id="PWY-8040" name="ansatrienin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8272" name="Escherichia coli serotype O:49 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-399955" name="SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion"/>
            <pathway-xref db="Reactome" id="R-DME-5621575" name="CD209 (DC-SIGN) signaling"/>
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            <pathway-xref db="Reactome" id="R-GGA-9013423" name="RAC3 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-5654719" name="SHC-mediated cascade:FGFR4"/>
            <pathway-xref db="Reactome" id="R-SPO-156842" name="Eukaryotic Translation Elongation"/>
            <pathway-xref db="Reactome" id="R-RNO-195253" name="Degradation of beta-catenin by the destruction complex"/>
            <pathway-xref db="Reactome" id="R-GGA-9634635" name="Estrogen-stimulated signaling through PRKCZ"/>
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            <pathway-xref db="Reactome" id="R-CFA-1169408" name="ISG15 antiviral mechanism"/>
            <pathway-xref db="MetaCyc" id="PWY-5316" name="nicotine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DRE-429947" name="Deadenylation of mRNA"/>
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            <pathway-xref db="Reactome" id="R-MMU-2500257" name="Resolution of Sister Chromatid Cohesion"/>
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            <pathway-xref db="Reactome" id="R-CEL-349425" name="Autodegradation of the E3 ubiquitin ligase COP1"/>
            <pathway-xref db="Reactome" id="R-SSC-5673000" name="RAF activation"/>
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            <pathway-xref db="Reactome" id="R-MMU-3214858" name="RMTs methylate histone arginines"/>
            <pathway-xref db="Reactome" id="R-DME-216217" name="Activation of SMO"/>
            <pathway-xref db="MetaCyc" id="PWY-6153" name="autoinducer AI-2 biosynthesis I"/>
            <pathway-xref db="Reactome" id="R-RNO-8856828" name="Clathrin-mediated endocytosis"/>
            <pathway-xref db="MetaCyc" id="PWY-7727" name="docosahexaenoate biosynthesis IV (4-desaturase, mammals)"/>
            <pathway-xref db="Reactome" id="R-MMU-392451" name="G beta:gamma signalling through PI3Kgamma"/>
            <pathway-xref db="Reactome" id="R-DME-6804758" name="Regulation of TP53 Activity through Acetylation"/>
            <pathway-xref db="Reactome" id="R-DME-77595" name="Processing of Intronless Pre-mRNAs"/>
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            <pathway-xref db="Reactome" id="R-DME-350368" name="Activation of RHO1 by FZ:DSH complex"/>
            <pathway-xref db="Reactome" id="R-DME-451308" name="Activation of Ca-permeable Kainate Receptor"/>
            <pathway-xref db="Reactome" id="R-HSA-4551638" name="SUMOylation of chromatin organization proteins"/>
            <pathway-xref db="Reactome" id="R-RNO-8851805" name="MET activates RAS signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-111457" name="Release of apoptotic factors from the mitochondria"/>
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            <pathway-xref db="Reactome" id="R-MMU-5693548" name="Sensing of DNA Double Strand Breaks"/>
            <pathway-xref db="Reactome" id="R-HSA-2161517" name="Abacavir transmembrane transport"/>
            <pathway-xref db="Reactome" id="R-RNO-4086400" name="PCP/CE pathway"/>
            <pathway-xref db="Reactome" id="R-HSA-9673770" name="Signaling by PDGFRA extracellular domain mutants"/>
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            <pathway-xref db="Reactome" id="R-MMU-354194" name="GRB2:SOS provides linkage to MAPK signaling for Integrins"/>
            <pathway-xref db="Reactome" id="R-HSA-6799198" name="Complex I biogenesis"/>
            <pathway-xref db="Reactome" id="R-SPO-174113" name="SCF-beta-TrCP mediated degradation of Emi1"/>
            <pathway-xref db="MetaCyc" id="PWY-7563" name="bassianin and desmethylbassianin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-3542" name="choline biosynthesis II"/>
            <pathway-xref db="Reactome" id="R-DME-5696400" name="Dual Incision in GG-NER"/>
            <pathway-xref db="Reactome" id="R-MMU-5696394" name="DNA Damage Recognition in GG-NER"/>
            <pathway-xref db="Reactome" id="R-DRE-9013408" name="RHOG GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-68689" name="CDC6 association with the ORC:origin complex"/>
            <pathway-xref db="Reactome" id="R-RNO-1655829" name="Regulation of cholesterol biosynthesis by SREBP (SREBF)"/>
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            <pathway-xref db="Reactome" id="R-SPO-8873719" name="RAB geranylgeranylation"/>
            <pathway-xref db="MetaCyc" id="PWY-7161" name="polymethylated quercetin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-5663213" name="RHO GTPases Activate WASPs and WAVEs"/>
            <pathway-xref db="Reactome" id="R-CEL-8964616" name="G beta:gamma signalling through CDC42"/>
            <pathway-xref db="Reactome" id="R-HSA-1799339" name="SRP-dependent cotranslational protein targeting to membrane"/>
            <pathway-xref db="Reactome" id="R-HSA-380259" name="Loss of Nlp from mitotic centrosomes"/>
            <pathway-xref db="Reactome" id="R-MMU-9013407" name="RHOH GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-7039" name="phosphatidate metabolism, as a signaling molecule"/>
            <pathway-xref db="Reactome" id="R-MMU-193368" name="Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol"/>
            <pathway-xref db="Reactome" id="R-DME-68884" name="Mitotic Telophase/Cytokinesis"/>
            <pathway-xref db="Reactome" id="R-HSA-6804756" name="Regulation of TP53 Activity through Phosphorylation"/>
            <pathway-xref db="Reactome" id="R-XTR-114608" name="Platelet degranulation"/>
            <pathway-xref db="Reactome" id="R-RNO-5627123" name="RHO GTPases activate PAKs"/>
            <pathway-xref db="Reactome" id="R-CEL-6791226" name="Major pathway of rRNA processing in the nucleolus and cytosol"/>
            <pathway-xref db="Reactome" id="R-SCE-392517" name="Rap1 signalling"/>
            <pathway-xref db="Reactome" id="R-HSA-112043" name="PLC beta mediated events"/>
            <pathway-xref db="Reactome" id="R-RNO-437239" name="Recycling pathway of L1"/>
            <pathway-xref db="Reactome" id="R-MMU-399997" name="Acetylcholine regulates insulin secretion"/>
            <pathway-xref db="Reactome" id="R-HSA-1433557" name="Signaling by SCF-KIT"/>
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            <pathway-xref db="Reactome" id="R-RNO-9013148" name="CDC42 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DME-445144" name="Signal transduction by L1"/>
            <pathway-xref db="Reactome" id="R-HSA-917937" name="Iron uptake and transport"/>
            <pathway-xref db="Reactome" id="R-SPO-917729" name="Endosomal Sorting Complex Required For Transport (ESCRT)"/>
            <pathway-xref db="Reactome" id="R-DDI-196807" name="Nicotinate metabolism"/>
            <pathway-xref db="MetaCyc" id="PWY-5105" name="hesperitin glycoside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-199992" name="trans-Golgi Network Vesicle Budding"/>
            <pathway-xref db="Reactome" id="R-HSA-9694686" name="Replication of the SARS-CoV-2 genome"/>
            <pathway-xref db="Reactome" id="R-HSA-8853884" name="Transcriptional Regulation by VENTX"/>
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            <pathway-xref db="Reactome" id="R-MMU-6807878" name="COPI-mediated anterograde transport"/>
            <pathway-xref db="Reactome" id="R-GGA-174411" name="Polymerase switching on the C-strand of the telomere"/>
            <pathway-xref db="Reactome" id="R-DME-8951664" name="Neddylation"/>
            <pathway-xref db="Reactome" id="R-MMU-1296025" name="ATP sensitive Potassium channels"/>
            <pathway-xref db="Reactome" id="R-CEL-9013406" name="RHOQ GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-77595" name="Processing of Intronless Pre-mRNAs"/>
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            <pathway-xref db="MetaCyc" id="PWY-7729" name="5,6-dimethylbenzimidazole biosynthesis II (anaerobic)"/>
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            <pathway-xref db="Reactome" id="R-MMU-191859" name="snRNP Assembly"/>
            <pathway-xref db="Reactome" id="R-GGA-9013406" name="RHOQ GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DDI-437239" name="Recycling pathway of L1"/>
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            <pathway-xref db="Reactome" id="R-GGA-5687128" name="MAPK6/MAPK4 signaling"/>
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            <pathway-xref db="Reactome" id="R-SCE-73817" name="Purine ribonucleoside monophosphate biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-DDI-5689603" name="UCH proteinases"/>
            <pathway-xref db="Reactome" id="R-DME-69091" name="Polymerase switching"/>
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            <pathway-xref db="MetaCyc" id="PWY-2161" name="folate polyglutamylation"/>
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            <pathway-xref db="MetaCyc" id="PWY-8086" name="(S)-lactate fermentation to propanoate, acetate and hydrogen"/>
            <pathway-xref db="Reactome" id="R-MMU-170984" name="ARMS-mediated activation"/>
            <pathway-xref db="MetaCyc" id="PWY-7222" name="guanosine deoxyribonucleotides de novo biosynthesis II"/>
            <pathway-xref db="Reactome" id="R-CEL-9035034" name="RHOF GTPase cycle"/>
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            <pathway-xref db="Reactome" id="R-GGA-68689" name="CDC6 association with the ORC:origin complex"/>
            <pathway-xref db="Reactome" id="R-MMU-8964058" name="HDL remodeling"/>
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            <pathway-xref db="Reactome" id="R-MMU-68827" name="CDT1 association with the CDC6:ORC:origin complex"/>
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            <pathway-xref db="Reactome" id="R-BTA-3134963" name="DEx/H-box helicases activate type I IFN and inflammatory cytokines production"/>
            <pathway-xref db="Reactome" id="R-HSA-9670613" name="Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations"/>
            <pathway-xref db="MetaCyc" id="PWY-5846" name="colchicine biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-CEL-186763" name="Downstream signal transduction"/>
            <pathway-xref db="Reactome" id="R-MMU-8875656" name="MET receptor recycling"/>
            <pathway-xref db="Reactome" id="R-HSA-9660826" name="Purinergic signaling in leishmaniasis infection"/>
            <pathway-xref db="Reactome" id="R-DDI-2142691" name="Synthesis of Leukotrienes (LT) and Eoxins (EX)"/>
            <pathway-xref db="Reactome" id="R-HSA-354192" name="Integrin signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-5656121" name="Translesion synthesis by POLI"/>
            <pathway-xref db="MetaCyc" id="PWY-7708" name="lyngbyatoxin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-1236974" name="ER-Phagosome pathway"/>
            <pathway-xref db="Reactome" id="R-CFA-5620916" name="VxPx cargo-targeting to cilium"/>
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            <pathway-xref db="Reactome" id="R-GGA-5627117" name="RHO GTPases Activate ROCKs"/>
            <pathway-xref db="Reactome" id="R-SCE-392451" name="G beta:gamma signalling through PI3Kgamma"/>
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            <pathway-xref db="Reactome" id="R-SCE-983189" name="Kinesins"/>
            <pathway-xref db="Reactome" id="R-HSA-189483" name="Heme degradation"/>
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            <pathway-xref db="Reactome" id="R-SSC-5620916" name="VxPx cargo-targeting to cilium"/>
            <pathway-xref db="Reactome" id="R-HSA-9682706" name="Replication of the SARS-CoV-1 genome"/>
            <pathway-xref db="Reactome" id="R-CFA-9013408" name="RHOG GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-351906" name="Apoptotic cleavage of cell adhesion proteins"/>
            <pathway-xref db="Reactome" id="R-SCE-9013148" name="CDC42 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-SSC-5607761" name="Dectin-1 mediated noncanonical NF-kB signaling"/>
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            <pathway-xref db="Reactome" id="R-RNO-888590" name="GABA synthesis, release, reuptake and degradation"/>
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            <pathway-xref db="Reactome" id="R-SPO-434316" name="Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion"/>
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            <pathway-xref db="Reactome" id="R-MMU-9035034" name="RHOF GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-6736" name="sulfur volatiles biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DDI-5358606" name="Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)"/>
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            <pathway-xref db="Reactome" id="R-DME-5693565" name="Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks"/>
            <pathway-xref db="Reactome" id="R-CFA-9013148" name="CDC42 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-428543" name="Inactivation of CDC42 and RAC1"/>
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            <pathway-xref db="Reactome" id="R-HSA-9683439" name="Assembly of the SARS-CoV-1 Replication-Transcription Complex (RTC)"/>
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            <pathway-xref db="Reactome" id="R-HSA-5625900" name="RHO GTPases activate CIT"/>
            <pathway-xref db="Reactome" id="R-MMU-9013406" name="RHOQ GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-7150" name="polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)"/>
            <pathway-xref db="Reactome" id="R-MMU-418597" name="G alpha (z) signalling events"/>
            <pathway-xref db="Reactome" id="R-SPO-159236" name="Transport of Mature mRNA derived from an Intron-Containing Transcript"/>
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            <pathway-xref db="MetaCyc" id="PWY-5139" name="pelargonidin conjugates biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7151" name="polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)"/>
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            <pathway-xref db="Reactome" id="R-DME-77075" name="RNA Pol II CTD phosphorylation and interaction with CE"/>
            <pathway-xref db="Reactome" id="R-CFA-9009391" name="Extra-nuclear estrogen signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-983231" name="Factors involved in megakaryocyte development and platelet production"/>
            <pathway-xref db="Reactome" id="R-DME-418594" name="G alpha (i) signalling events"/>
            <pathway-xref db="Reactome" id="R-DDI-75953" name="RNA Polymerase II Transcription Initiation"/>
            <pathway-xref db="Reactome" id="R-HSA-5675221" name="Negative regulation of MAPK pathway"/>
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            <pathway-xref db="Reactome" id="R-RNO-110320" name="Translesion Synthesis by POLH"/>
            <pathway-xref db="Reactome" id="R-MMU-111469" name="SMAC, XIAP-regulated apoptotic response"/>
            <pathway-xref db="Reactome" id="R-DME-6799198" name="Complex I biogenesis"/>
            <pathway-xref db="Reactome" id="R-MMU-5687128" name="MAPK6/MAPK4 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-9013425" name="RHOT1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-9679504" name="Translation of Replicase and Assembly of the Replication Transcription Complex"/>
            <pathway-xref db="Reactome" id="R-DDI-75153" name="Apoptotic execution phase"/>
            <pathway-xref db="Reactome" id="R-MMU-2514859" name="Inactivation, recovery and regulation of the phototransduction cascade"/>
            <pathway-xref db="Reactome" id="R-MMU-8849932" name="Synaptic adhesion-like molecules"/>
            <pathway-xref db="Reactome" id="R-HSA-399719" name="Trafficking of AMPA receptors"/>
            <pathway-xref db="Reactome" id="R-DME-2173791" name="TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)"/>
            <pathway-xref db="Reactome" id="R-RNO-5673001" name="RAF/MAP kinase cascade"/>
            <pathway-xref db="Reactome" id="R-DDI-1660516" name="Synthesis of PIPs at the early endosome membrane"/>
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            <pathway-xref db="Reactome" id="R-SPO-6811438" name="Intra-Golgi traffic"/>
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        </signature>
        <model-ac>0048956</model-ac>
        <locations>
          <superfamilyhmmer3-location hmm-length="626" start="1359" end="1870">
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        </locations>
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  </protein>
  <protein>
    <sequence md5="dcab942ffadca615a808020ddefe84d3">MRFSMTSLNLLTAPGSKKVAMARSPGLRAYAFRVLALVIFLFTLWLLYSHLGHHGAHQALPHGNQPEVSNAVNQSIMLFLSLNITYLLALLTYYNTPRPPKAHTPPTTQISRSDDTSTSHSPLLLAALTTTPLPKSGKVVVEVYYEVLCPDSRYFILKQLYPTWQRVGSIMDIQYKPYGKASHRASDGGYMFQCQHGPNECQGNMIHTCAMHYIPESTKLTEYIHCMMGDNYDPMQAGRNCASQLEIEWSPIEACASGKEGQKMLAVVGDDTHSLRPRVSFIPTIVLNGSQDNQKMMLKNLLKEVCRKYQGVKPKECIETL</sequence>
    <xref id="TCALIF_00755-PA" name="TCALIF_00755-PA protein Name:&quot;Similar to IFI30 Gamma-interferon-inducible lysosomal thiol reductase (Bos taurus)&quot; AED:0.19 eAED:0.19 QI:0|0.66|0.57|1|0.83|0.85|7|335|321"/>
    <matches>
      <hmmer3-match evalue="1.6E-33" score="115.2">
        <signature ac="PF03227" desc="Gamma interferon inducible lysosomal thiol reductase (GILT)" name="GILT">
          <entry ac="IPR004911" desc="Gamma interferon inducible lysosomal thiol reductase GILT" name="Interferon-induced_GILT" type="FAMILY">
            <go-xref category="MOLECULAR_FUNCTION" db="GO" id="GO:0016671" name="oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor"/>
            <pathway-xref db="Reactome" id="R-MMU-2132295" name="MHC class II antigen presentation"/>
            <pathway-xref db="Reactome" id="R-RNO-2132295" name="MHC class II antigen presentation"/>
            <pathway-xref db="Reactome" id="R-CEL-2132295" name="MHC class II antigen presentation"/>
            <pathway-xref db="Reactome" id="R-HSA-2132295" name="MHC class II antigen presentation"/>
            <pathway-xref db="Reactome" id="R-HSA-877300" name="Interferon gamma signaling"/>
            <pathway-xref db="Reactome" id="R-DRE-2132295" name="MHC class II antigen presentation"/>
            <pathway-xref db="Reactome" id="R-DME-2132295" name="MHC class II antigen presentation"/>
          </entry>
          <signature-library-release library="PFAM" version="34.0"/>
        </signature>
        <model-ac>PF03227</model-ac>
        <locations>
          <hmmer3-location env-end="245" env-start="140" post-processed="true" score="114.5" evalue="2.6E-33" hmm-start="2" hmm-end="106" hmm-length="107" hmm-bounds="INCOMPLETE" start="141" end="244">
            <location-fragments>
              <hmmer3-location-fragment start="141" end="244" dc-status="CONTINUOUS"/>
            </location-fragments>
          </hmmer3-location>
        </locations>
      </hmmer3-match>
      <panther-match evalue="3.2E-69" familyName="GAMMA-INTERFERON-INDUCIBLE LYSOSOMAL THIOL REDUCTASE-LIKE PROTEIN" score="244.3">
        <signature ac="PTHR13234" name="GAMMA-INTERFERON INDUCIBLE LYSOSOMAL THIOL REDUCTASE  GILT">
          <entry ac="IPR004911" desc="Gamma interferon inducible lysosomal thiol reductase GILT" name="Interferon-induced_GILT" type="FAMILY">
            <go-xref category="MOLECULAR_FUNCTION" db="GO" id="GO:0016671" name="oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor"/>
            <pathway-xref db="Reactome" id="R-MMU-2132295" name="MHC class II antigen presentation"/>
            <pathway-xref db="Reactome" id="R-RNO-2132295" name="MHC class II antigen presentation"/>
            <pathway-xref db="Reactome" id="R-CEL-2132295" name="MHC class II antigen presentation"/>
            <pathway-xref db="Reactome" id="R-HSA-2132295" name="MHC class II antigen presentation"/>
            <pathway-xref db="Reactome" id="R-HSA-877300" name="Interferon gamma signaling"/>
            <pathway-xref db="Reactome" id="R-DRE-2132295" name="MHC class II antigen presentation"/>
            <pathway-xref db="Reactome" id="R-DME-2132295" name="MHC class II antigen presentation"/>
          </entry>
          <signature-library-release library="PANTHER" version="15.0"/>
        </signature>
        <model-ac>PTHR13234</model-ac>
        <locations>
          <panther-location env-start="115" env-end="318" hmm-start="41" hmm-end="229" hmm-length="230" hmm-bounds="INCOMPLETE" start="132" end="317">
            <location-fragments>
              <panther-location-fragment start="132" end="317" dc-status="CONTINUOUS"/>
            </location-fragments>
          </panther-location>
        </locations>
      </panther-match>
      <panther-match evalue="3.2E-69" familyName="GAMMA-INTERFERON-INDUCIBLE LYSOSOMAL THIOL REDUCTASE-LIKE PROTEIN" score="244.3">
        <signature ac="PTHR13234:SF59" name="GAMMA-INTERFERON-INDUCIBLE LYSOSOMAL THIOL REDUCTASE-LIKE PROTEIN">
          <signature-library-release library="PANTHER" version="15.0"/>
        </signature>
        <model-ac>PTHR13234:SF59</model-ac>
        <locations>
          <panther-location env-start="115" env-end="318" hmm-start="41" hmm-end="229" hmm-length="230" hmm-bounds="INCOMPLETE" start="132" end="317">
            <location-fragments>
              <panther-location-fragment start="132" end="317" dc-status="CONTINUOUS"/>
            </location-fragments>
          </panther-location>
        </locations>
      </panther-match>
    </matches>
  </protein>
  <protein>
    <sequence md5="8f1da351a401c037f6034cac8042af0e">MCPINRGAPTESSQFGEQVSHLVQGAKRIRSRSPNQREIEVTFSHCKRSVNQVNPWHDEKTGQKKDFDQHHHPHHDHHGPKSAQGKPGRTASPFIYDNEATDVVNTVQTADTTVHDYDLPRELPDPSGSRPLSVDGVAHVQRNEELPAEEATALVSMPDGATEVIYFPPGKGEIKEIPGMGSVLETTQPDGRVVRYPVIGHALDEDEEARQMAIINETATKLPSFNKILHSSSDQAEDQRRKEDGAPTFTELTVPTSMQGEDVLSPSAAHAKVYADLDAAQPTTSMGTLDLQSQPPHHSEGEHSYLPWNYYNHEDRPSPIEAQGLSGHPYDPQYASSSSDLYGEDMTGLGQGPAQYSLRPDLGNPPEASSMVWPGPPMHPNTDNHCILIQRVPQRGRKSKGTGKTGANRFDDEVKREQYKRSACDRERARMKDMNKSFELLRKRLPFCKPPGKRLSKIESLRLAIKYIKHLQYLLSFPISQKIPPHIVEFDSTLPAWVKNPSIPGATIIGDLEGSGNYIHTDDLWITTSVRGPTMEQPLVYEGYAS</sequence>
    <xref id="TCALIF_00243-PA" name="TCALIF_00243-PA protein Name:&quot;Similar to tcf21 Transcription factor 21 (Danio rerio)&quot; AED:0.01 eAED:0.01 QI:0|0.6|0.5|1|1|1|6|45|546"/>
    <matches>
      <hmmer2-match evalue="6.7E-14" score="62.2">
        <signature ac="SM00353" name="finulus">
          <entry ac="IPR011598" desc="Myc-type, basic helix-loop-helix (bHLH) domain" name="bHLH_dom" type="DOMAIN">
            <go-xref category="MOLECULAR_FUNCTION" db="GO" id="GO:0046983" name="protein dimerization activity"/>
            <pathway-xref db="Reactome" id="R-RNO-211981" name="Xenobiotics"/>
            <pathway-xref db="Reactome" id="R-HSA-211976" name="Endogenous sterols"/>
            <pathway-xref db="Reactome" id="R-RNO-1655829" name="Regulation of cholesterol biosynthesis by SREBP (SREBF)"/>
            <pathway-xref db="Reactome" id="R-MMU-8937144" name="Aryl hydrocarbon receptor signalling"/>
            <pathway-xref db="Reactome" id="R-MMU-525793" name="Myogenesis"/>
            <pathway-xref db="Reactome" id="R-DRE-193807" name="Synthesis of bile acids and bile salts via 27-hydroxycholesterol"/>
            <pathway-xref db="Reactome" id="R-HSA-9018519" name="Estrogen-dependent gene expression"/>
            <pathway-xref db="Reactome" id="R-HSA-9029569" name="NR1H3 &amp; NR1H2 regulate gene expression linked to cholesterol transport and efflux"/>
            <pathway-xref db="Reactome" id="R-MMU-193368" name="Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol"/>
            <pathway-xref db="Reactome" id="R-HSA-163765" name="ChREBP activates metabolic gene expression"/>
            <pathway-xref db="Reactome" id="R-DME-8866911" name="TFAP2 (AP-2) family regulates transcription of cell cycle factors"/>
            <pathway-xref db="Reactome" id="R-HSA-159418" name="Recycling of bile acids and salts"/>
            <pathway-xref db="Reactome" id="R-HSA-9664873" name="Pexophagy"/>
            <pathway-xref db="Reactome" id="R-DME-1234176" name="Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha"/>
            <pathway-xref db="Reactome" id="R-DME-432501" name="Transcription repression by PER and activation by PDP1"/>
            <pathway-xref db="Reactome" id="R-MMU-211945" name="Phase I - Functionalization of compounds"/>
            <pathway-xref db="Reactome" id="R-HSA-163358" name="PKA-mediated phosphorylation of key metabolic factors"/>
            <pathway-xref db="Reactome" id="R-DRE-8937144" name="Aryl hydrocarbon receptor signalling"/>
            <pathway-xref db="Reactome" id="R-RNO-163765" name="ChREBP activates metabolic gene expression"/>
            <pathway-xref db="Reactome" id="R-DRE-8866911" name="TFAP2 (AP-2) family regulates transcription of cell cycle factors"/>
            <pathway-xref db="Reactome" id="R-MMU-1234176" name="Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha"/>
            <pathway-xref db="Reactome" id="R-HSA-210746" name="Regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells"/>
            <pathway-xref db="Reactome" id="R-HSA-193807" name="Synthesis of bile acids and bile salts via 27-hydroxycholesterol"/>
            <pathway-xref db="Reactome" id="R-DRE-192105" name="Synthesis of bile acids and bile salts"/>
            <pathway-xref db="Reactome" id="R-RNO-211945" name="Phase I - Functionalization of compounds"/>
            <pathway-xref db="Reactome" id="R-HSA-2151201" name="Transcriptional activation of mitochondrial biogenesis"/>
            <pathway-xref db="Reactome" id="R-MMU-3899300" name="SUMOylation of transcription cofactors"/>
            <pathway-xref db="Reactome" id="R-HSA-211981" name="Xenobiotics"/>
            <pathway-xref db="Reactome" id="R-BTA-525793" name="Myogenesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9031628" name="NGF-stimulated transcription"/>
            <pathway-xref db="Reactome" id="R-CEL-163358" name="PKA-mediated phosphorylation of key metabolic factors"/>
            <pathway-xref db="Reactome" id="R-RNO-8939236" name="RUNX1 regulates transcription of genes involved in differentiation of HSCs"/>
            <pathway-xref db="Reactome" id="R-RNO-211976" name="Endogenous sterols"/>
            <pathway-xref db="Reactome" id="R-RNO-159418" name="Recycling of bile acids and salts"/>
            <pathway-xref db="Reactome" id="R-DME-432560" name="Transcription activation by CLK:CYC and repression by VRI"/>
            <pathway-xref db="Reactome" id="R-MMU-9018519" name="Estrogen-dependent gene expression"/>
            <pathway-xref db="Reactome" id="R-HSA-9707564" name="Cytoprotection by HMOX1"/>
            <pathway-xref db="Reactome" id="R-HSA-211945" name="Phase I - Functionalization of compounds"/>
            <pathway-xref db="Reactome" id="R-RNO-525793" name="Myogenesis"/>
            <pathway-xref db="Reactome" id="R-DME-432620" name="Dephosphorylation of PER"/>
            <pathway-xref db="Reactome" id="R-MMU-5687128" name="MAPK6/MAPK4 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-8951430" name="RUNX3 regulates WNT signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-8857538" name="PTK6 promotes HIF1A stabilization"/>
            <pathway-xref db="Reactome" id="R-HSA-8937144" name="Aryl hydrocarbon receptor signalling"/>
            <pathway-xref db="Reactome" id="R-RNO-5625886" name="Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3"/>
            <pathway-xref db="Reactome" id="R-DME-432524" name="Degradation of PER"/>
            <pathway-xref db="Reactome" id="R-RNO-8951664" name="Neddylation"/>
            <pathway-xref db="Reactome" id="R-RNO-2559585" name="Oncogene Induced Senescence"/>
            <pathway-xref db="Reactome" id="R-DRE-9018519" name="Estrogen-dependent gene expression"/>
            <pathway-xref db="Reactome" id="R-DME-8951664" name="Neddylation"/>
            <pathway-xref db="Reactome" id="R-HSA-525793" name="Myogenesis"/>
            <pathway-xref db="Reactome" id="R-MMU-211976" name="Endogenous sterols"/>
            <pathway-xref db="Reactome" id="R-HSA-400253" name="Circadian Clock"/>
            <pathway-xref db="Reactome" id="R-CEL-8937144" name="Aryl hydrocarbon receptor signalling"/>
            <pathway-xref db="Reactome" id="R-MMU-8866911" name="TFAP2 (AP-2) family regulates transcription of cell cycle factors"/>
            <pathway-xref db="Reactome" id="R-HSA-1234174" name="Cellular response to hypoxia"/>
            <pathway-xref db="Reactome" id="R-HSA-163767" name="PP2A-mediated dephosphorylation of key metabolic factors"/>
            <pathway-xref db="Reactome" id="R-DME-8937144" name="Aryl hydrocarbon receptor signalling"/>
            <pathway-xref db="Reactome" id="R-HSA-9623433" name="NR1H2 &amp; NR1H3 regulate gene expression to control bile acid homeostasis"/>
            <pathway-xref db="Reactome" id="R-HSA-9619665" name="EGR2 and SOX10-mediated initiation of Schwann cell myelination"/>
            <pathway-xref db="Reactome" id="R-DME-8953750" name="Transcriptional Regulation by E2F6"/>
            <pathway-xref db="Reactome" id="R-DRE-159418" name="Recycling of bile acids and salts"/>
            <pathway-xref db="Reactome" id="R-HSA-8849473" name="PTK6 Expression"/>
            <pathway-xref db="Reactome" id="R-GGA-9018519" name="Estrogen-dependent gene expression"/>
            <pathway-xref db="Reactome" id="R-MMU-192105" name="Synthesis of bile acids and bile salts"/>
            <pathway-xref db="Reactome" id="R-RNO-9707564" name="Cytoprotection by HMOX1"/>
            <pathway-xref db="Reactome" id="R-HSA-3214847" name="HATs acetylate histones"/>
            <pathway-xref db="Reactome" id="R-RNO-163358" name="PKA-mediated phosphorylation of key metabolic factors"/>
            <pathway-xref db="Reactome" id="R-MMU-9623433" name="NR1H2 &amp; NR1H3 regulate gene expression to control bile acid homeostasis"/>
            <pathway-xref db="Reactome" id="R-HSA-9029558" name="NR1H2 &amp; NR1H3 regulate gene expression linked to lipogenesis"/>
            <pathway-xref db="Reactome" id="R-BTA-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-MMU-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-HSA-1368082" name="RORA activates gene expression"/>
            <pathway-xref db="Reactome" id="R-MMU-1234158" name="Regulation of gene expression by Hypoxia-inducible Factor"/>
            <pathway-xref db="Reactome" id="R-DRE-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-CEL-8953750" name="Transcriptional Regulation by E2F6"/>
            <pathway-xref db="Reactome" id="R-RNO-8857538" name="PTK6 promotes HIF1A stabilization"/>
            <pathway-xref db="Reactome" id="R-HSA-381340" name="Transcriptional regulation of white adipocyte differentiation"/>
            <pathway-xref db="Reactome" id="R-HSA-9616222" name="Transcriptional regulation of granulopoiesis"/>
            <pathway-xref db="Reactome" id="R-HSA-1368108" name="BMAL1:CLOCK,NPAS2 activates circadian gene expression"/>
            <pathway-xref db="Reactome" id="R-DME-432626" name="Circadian Clock pathway"/>
            <pathway-xref db="Reactome" id="R-HSA-8940973" name="RUNX2 regulates osteoblast differentiation"/>
            <pathway-xref db="Reactome" id="R-MMU-193807" name="Synthesis of bile acids and bile salts via 27-hydroxycholesterol"/>
            <pathway-xref db="Reactome" id="R-HSA-2173796" name="SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription"/>
            <pathway-xref db="Reactome" id="R-DRE-211945" name="Phase I - Functionalization of compounds"/>
            <pathway-xref db="Reactome" id="R-BTA-8866911" name="TFAP2 (AP-2) family regulates transcription of cell cycle factors"/>
            <pathway-xref db="Reactome" id="R-HSA-1234176" name="Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha"/>
            <pathway-xref db="Reactome" id="R-MMU-163765" name="ChREBP activates metabolic gene expression"/>
            <pathway-xref db="Reactome" id="R-GGA-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-HSA-163680" name="AMPK inhibits chREBP transcriptional activation activity"/>
            <pathway-xref db="Reactome" id="R-RNO-1234176" name="Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha"/>
            <pathway-xref db="Reactome" id="R-MMU-211981" name="Xenobiotics"/>
            <pathway-xref db="Reactome" id="R-HSA-1251985" name="Nuclear signaling by ERBB4"/>
            <pathway-xref db="Reactome" id="R-MMU-8939236" name="RUNX1 regulates transcription of genes involved in differentiation of HSCs"/>
            <pathway-xref db="Reactome" id="R-HSA-4411364" name="Binding of TCF/LEF:CTNNB1 to target gene promoters"/>
            <pathway-xref db="Reactome" id="R-HSA-192105" name="Synthesis of bile acids and bile salts"/>
            <pathway-xref db="Reactome" id="R-HSA-8857538" name="PTK6 promotes HIF1A stabilization"/>
            <pathway-xref db="Reactome" id="R-HSA-8951664" name="Neddylation"/>
            <pathway-xref db="Reactome" id="R-RNO-1234174" name="Cellular response to hypoxia"/>
            <pathway-xref db="Reactome" id="R-BTA-9018519" name="Estrogen-dependent gene expression"/>
            <pathway-xref db="Reactome" id="R-MMU-3232118" name="SUMOylation of transcription factors"/>
            <pathway-xref db="Reactome" id="R-XTR-5625886" name="Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3"/>
            <pathway-xref db="Reactome" id="R-MMU-2559585" name="Oncogene Induced Senescence"/>
            <pathway-xref db="Reactome" id="R-DRE-193368" name="Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol"/>
            <pathway-xref db="Reactome" id="R-HSA-3232118" name="SUMOylation of transcription factors"/>
            <pathway-xref db="Reactome" id="R-CEL-525793" name="Myogenesis"/>
            <pathway-xref db="Reactome" id="R-HSA-2559585" name="Oncogene Induced Senescence"/>
            <pathway-xref db="Reactome" id="R-DRE-1655829" name="Regulation of cholesterol biosynthesis by SREBP (SREBF)"/>
            <pathway-xref db="Reactome" id="R-HSA-69202" name="Cyclin E associated events during G1/S transition"/>
            <pathway-xref db="Reactome" id="R-MMU-400206" name="Regulation of lipid metabolism by PPARalpha"/>
            <pathway-xref db="Reactome" id="R-RNO-3214847" name="HATs acetylate histones"/>
            <pathway-xref db="Reactome" id="R-CEL-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-CEL-211945" name="Phase I - Functionalization of compounds"/>
            <pathway-xref db="Reactome" id="R-MMU-163358" name="PKA-mediated phosphorylation of key metabolic factors"/>
            <pathway-xref db="Reactome" id="R-HSA-8939236" name="RUNX1 regulates transcription of genes involved in differentiation of HSCs"/>
            <pathway-xref db="Reactome" id="R-HSA-2426168" name="Activation of gene expression by SREBF (SREBP)"/>
            <pathway-xref db="Reactome" id="R-RNO-400206" name="Regulation of lipid metabolism by PPARalpha"/>
            <pathway-xref db="Reactome" id="R-HSA-2197563" name="NOTCH2 intracellular domain regulates transcription"/>
            <pathway-xref db="Reactome" id="R-SCE-3232118" name="SUMOylation of transcription factors"/>
            <pathway-xref db="Reactome" id="R-CEL-1234176" name="Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha"/>
            <pathway-xref db="Reactome" id="R-HSA-1234158" name="Regulation of gene expression by Hypoxia-inducible Factor"/>
            <pathway-xref db="Reactome" id="R-DME-432408" name="Transcription regulation of cwo gene"/>
            <pathway-xref db="Reactome" id="R-HSA-193368" name="Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol"/>
            <pathway-xref db="Reactome" id="R-HSA-210745" name="Regulation of gene expression in beta cells"/>
            <pathway-xref db="Reactome" id="R-HSA-8878166" name="Transcriptional regulation by RUNX2"/>
            <pathway-xref db="Reactome" id="R-DRE-8939236" name="RUNX1 regulates transcription of genes involved in differentiation of HSCs"/>
            <pathway-xref db="Reactome" id="R-RNO-8953750" name="Transcriptional Regulation by E2F6"/>
            <pathway-xref db="Reactome" id="R-HSA-8953750" name="Transcriptional Regulation by E2F6"/>
            <pathway-xref db="Reactome" id="R-HSA-8866911" name="TFAP2 (AP-2) family regulates transcription of cell cycle factors"/>
            <pathway-xref db="Reactome" id="R-MMU-1655829" name="Regulation of cholesterol biosynthesis by SREBP (SREBF)"/>
            <pathway-xref db="Reactome" id="R-RNO-8937144" name="Aryl hydrocarbon receptor signalling"/>
            <pathway-xref db="Reactome" id="R-DME-432395" name="Degradation of TIM"/>
            <pathway-xref db="Reactome" id="R-DRE-5625886" name="Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3"/>
            <pathway-xref db="Reactome" id="R-HSA-9013695" name="NOTCH4 Intracellular Domain Regulates Transcription"/>
            <pathway-xref db="Reactome" id="R-CEL-8951664" name="Neddylation"/>
            <pathway-xref db="Reactome" id="R-MMU-8951664" name="Neddylation"/>
            <pathway-xref db="Reactome" id="R-RNO-8866911" name="TFAP2 (AP-2) family regulates transcription of cell cycle factors"/>
            <pathway-xref db="Reactome" id="R-HSA-1655829" name="Regulation of cholesterol biosynthesis by SREBP (SREBF)"/>
            <pathway-xref db="Reactome" id="R-MMU-5625886" name="Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3"/>
            <pathway-xref db="Reactome" id="R-MMU-159418" name="Recycling of bile acids and salts"/>
            <pathway-xref db="Reactome" id="R-HSA-2894862" name="Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants"/>
            <pathway-xref db="Reactome" id="R-DRE-211981" name="Xenobiotics"/>
            <pathway-xref db="Reactome" id="R-RNO-9018519" name="Estrogen-dependent gene expression"/>
            <pathway-xref db="Reactome" id="R-HSA-400206" name="Regulation of lipid metabolism by PPARalpha"/>
            <pathway-xref db="Reactome" id="R-RNO-3232118" name="SUMOylation of transcription factors"/>
            <pathway-xref db="Reactome" id="R-DRE-9707564" name="Cytoprotection by HMOX1"/>
            <pathway-xref db="Reactome" id="R-RNO-193807" name="Synthesis of bile acids and bile salts via 27-hydroxycholesterol"/>
            <pathway-xref db="Reactome" id="R-HSA-5625886" name="Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3"/>
            <pathway-xref db="Reactome" id="R-HSA-1989781" name="PPARA activates gene expression"/>
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            <pathway-xref db="Reactome" id="R-HSA-9029569" name="NR1H3 &amp; NR1H2 regulate gene expression linked to cholesterol transport and efflux"/>
            <pathway-xref db="MetaCyc" id="PWY-8176" name="geraniol biosynthesis (cytosol)"/>
            <pathway-xref db="Reactome" id="R-MMU-193368" name="Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol"/>
            <pathway-xref db="MetaCyc" id="PWY-7863" name="roseoflavin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-163765" name="ChREBP activates metabolic gene expression"/>
            <pathway-xref db="Reactome" id="R-HSA-159418" name="Recycling of bile acids and salts"/>
            <pathway-xref db="Reactome" id="R-HSA-9664873" name="Pexophagy"/>
            <pathway-xref db="Reactome" id="R-DME-432501" name="Transcription repression by PER and activation by PDP1"/>
            <pathway-xref db="Reactome" id="R-HSA-163358" name="PKA-mediated phosphorylation of key metabolic factors"/>
            <pathway-xref db="Reactome" id="R-DRE-8937144" name="Aryl hydrocarbon receptor signalling"/>
            <pathway-xref db="Reactome" id="R-DRE-8866911" name="TFAP2 (AP-2) family regulates transcription of cell cycle factors"/>
            <pathway-xref db="MetaCyc" id="PWY-6368" name="3-phosphoinositide degradation"/>
            <pathway-xref db="Reactome" id="R-RNO-211945" name="Phase I - Functionalization of compounds"/>
            <pathway-xref db="Reactome" id="R-DRE-192105" name="Synthesis of bile acids and bile salts"/>
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            <pathway-xref db="Reactome" id="R-MMU-9018519" name="Estrogen-dependent gene expression"/>
            <pathway-xref db="MetaCyc" id="PWY-6148" name="tetrahydromethanopterin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9707564" name="Cytoprotection by HMOX1"/>
            <pathway-xref db="Reactome" id="R-DME-432620" name="Dephosphorylation of PER"/>
            <pathway-xref db="Reactome" id="R-RNO-5625886" name="Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3"/>
            <pathway-xref db="MetaCyc" id="PWY-6366" name="D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-8951664" name="Neddylation"/>
            <pathway-xref db="Reactome" id="R-HSA-525793" name="Myogenesis"/>
            <pathway-xref db="Reactome" id="R-MMU-211976" name="Endogenous sterols"/>
            <pathway-xref db="Reactome" id="R-CEL-8937144" name="Aryl hydrocarbon receptor signalling"/>
            <pathway-xref db="Reactome" id="R-HSA-9623433" name="NR1H2 &amp; NR1H3 regulate gene expression to control bile acid homeostasis"/>
            <pathway-xref db="Reactome" id="R-DME-8953750" name="Transcriptional Regulation by E2F6"/>
            <pathway-xref db="Reactome" id="R-DRE-159418" name="Recycling of bile acids and salts"/>
            <pathway-xref db="Reactome" id="R-HSA-8849473" name="PTK6 Expression"/>
            <pathway-xref db="MetaCyc" id="PWY-6955" name="lincomycin A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-192105" name="Synthesis of bile acids and bile salts"/>
            <pathway-xref db="Reactome" id="R-RNO-9707564" name="Cytoprotection by HMOX1"/>
            <pathway-xref db="Reactome" id="R-MMU-9623433" name="NR1H2 &amp; NR1H3 regulate gene expression to control bile acid homeostasis"/>
            <pathway-xref db="Reactome" id="R-HSA-9029558" name="NR1H2 &amp; NR1H3 regulate gene expression linked to lipogenesis"/>
            <pathway-xref db="Reactome" id="R-BTA-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="MetaCyc" id="PWY-6352" name="3-phosphoinositide biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-1368082" name="RORA activates gene expression"/>
            <pathway-xref db="MetaCyc" id="PWY-7882" name="IM-2 type gamma-butyrolactones biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-1234158" name="Regulation of gene expression by Hypoxia-inducible Factor"/>
            <pathway-xref db="Reactome" id="R-DRE-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-CEL-8953750" name="Transcriptional Regulation by E2F6"/>
            <pathway-xref db="MetaCyc" id="PWY-6990" name="(+)-camphor biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-381340" name="Transcriptional regulation of white adipocyte differentiation"/>
            <pathway-xref db="MetaCyc" id="PWY-6575" name="juvenile hormone III biosynthesis I"/>
            <pathway-xref db="Reactome" id="R-DME-432626" name="Circadian Clock pathway"/>
            <pathway-xref db="Reactome" id="R-HSA-2173796" name="SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription"/>
            <pathway-xref db="Reactome" id="R-BTA-8866911" name="TFAP2 (AP-2) family regulates transcription of cell cycle factors"/>
            <pathway-xref db="Reactome" id="R-MMU-163765" name="ChREBP activates metabolic gene expression"/>
            <pathway-xref db="Reactome" id="R-HSA-1251985" name="Nuclear signaling by ERBB4"/>
            <pathway-xref db="Reactome" id="R-HSA-4411364" name="Binding of TCF/LEF:CTNNB1 to target gene promoters"/>
            <pathway-xref db="Reactome" id="R-HSA-192105" name="Synthesis of bile acids and bile salts"/>
            <pathway-xref db="Reactome" id="R-HSA-8951664" name="Neddylation"/>
            <pathway-xref db="Reactome" id="R-MMU-2559585" name="Oncogene Induced Senescence"/>
            <pathway-xref db="Reactome" id="R-DRE-193368" name="Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol"/>
            <pathway-xref db="Reactome" id="R-CEL-525793" name="Myogenesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7531" name="mannojirimycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-69202" name="Cyclin E associated events during G1/S transition"/>
            <pathway-xref db="Reactome" id="R-MMU-400206" name="Regulation of lipid metabolism by PPARalpha"/>
            <pathway-xref db="Reactome" id="R-RNO-3214847" name="HATs acetylate histones"/>
            <pathway-xref db="MetaCyc" id="PWY-6627" name="salinosporamide A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-163358" name="PKA-mediated phosphorylation of key metabolic factors"/>
            <pathway-xref db="Reactome" id="R-HSA-8939236" name="RUNX1 regulates transcription of genes involved in differentiation of HSCs"/>
            <pathway-xref db="Reactome" id="R-HSA-2426168" name="Activation of gene expression by SREBF (SREBP)"/>
            <pathway-xref db="Reactome" id="R-RNO-400206" name="Regulation of lipid metabolism by PPARalpha"/>
            <pathway-xref db="MetaCyc" id="PWY-6720" name="toyocamycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-2197563" name="NOTCH2 intracellular domain regulates transcription"/>
            <pathway-xref db="Reactome" id="R-SCE-3232118" name="SUMOylation of transcription factors"/>
            <pathway-xref db="Reactome" id="R-HSA-1234158" name="Regulation of gene expression by Hypoxia-inducible Factor"/>
            <pathway-xref db="Reactome" id="R-DME-432408" name="Transcription regulation of cwo gene"/>
            <pathway-xref db="Reactome" id="R-HSA-193368" name="Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol"/>
            <pathway-xref db="Reactome" id="R-HSA-210745" name="Regulation of gene expression in beta cells"/>
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            <pathway-xref db="Reactome" id="R-RNO-8953750" name="Transcriptional Regulation by E2F6"/>
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            <pathway-xref db="Reactome" id="R-HSA-8866911" name="TFAP2 (AP-2) family regulates transcription of cell cycle factors"/>
            <pathway-xref db="Reactome" id="R-DME-432395" name="Degradation of TIM"/>
            <pathway-xref db="Reactome" id="R-RNO-8866911" name="TFAP2 (AP-2) family regulates transcription of cell cycle factors"/>
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            <pathway-xref db="Reactome" id="R-HSA-2894862" name="Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants"/>
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            <pathway-xref db="Reactome" id="R-RNO-193368" name="Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol"/>
            <pathway-xref db="MetaCyc" id="PWY-5491" name="diethylphosphate degradation"/>
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            <pathway-xref db="MetaCyc" id="PWY-8247" name="(Kdo)2-lipid A biosynthesis (P. gingivalis)"/>
            <pathway-xref db="Reactome" id="R-HSA-2644606" name="Constitutive Signaling by NOTCH1 PEST Domain Mutants"/>
            <pathway-xref db="Reactome" id="R-CEL-3232118" name="SUMOylation of transcription factors"/>
            <pathway-xref db="Reactome" id="R-RNO-1234158" name="Regulation of gene expression by Hypoxia-inducible Factor"/>
            <pathway-xref db="MetaCyc" id="PWY-7321" name="ecdysteroid metabolism (arthropods)"/>
            <pathway-xref db="Reactome" id="R-HSA-9013508" name="NOTCH3 Intracellular Domain Regulates Transcription"/>
            <pathway-xref db="Reactome" id="R-DRE-3214847" name="HATs acetylate histones"/>
            <pathway-xref db="Reactome" id="R-RNO-192105" name="Synthesis of bile acids and bile salts"/>
            <pathway-xref db="Reactome" id="R-DME-8939236" name="RUNX1 regulates transcription of genes involved in differentiation of HSCs"/>
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            <pathway-xref db="Reactome" id="R-HSA-6785807" name="Interleukin-4 and Interleukin-13 signaling"/>
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          </entry>
          <signature-library-release library="SUPERFAMILY" version="1.75"/>
        </signature>
        <model-ac>0043065</model-ac>
        <locations>
          <superfamilyhmmer3-location hmm-length="87" start="417" end="478">
            <location-fragments>
              <superfamilyhmmer3-location-fragment start="417" end="478" dc-status="CONTINUOUS"/>
            </location-fragments>
          </superfamilyhmmer3-location>
        </locations>
      </superfamilyhmmer3-match>
    </matches>
  </protein>
  <protein>
    <sequence md5="f00ffd202588948f883934c3fc581570">MASSSSSSEPSSTSRTARKGTRGPAAKKLPIRNIVPRESETTSSSSSLVHSTSESAASTAALEAANSDVAAVSALQLLSAIKTEPSTSEIPEQLRRELLVRQPSYYKILNDLKGAEDMAKSEANSEVSTSEGSNSVQTITINGQQYQIVSALEGNAAGGASPPSGGSVIQYATATQNGQTVFVPSQNSVSAVSSAASSPQIVSVMGSPSGSHPRVAQDAARKREVRLMKNREAARECRNKKKEYIKCLENRVAVLENQNKALIEELKSLKELYTGQKS</sequence>
    <xref id="TCALIF_00359-PA" name="TCALIF_00359-PA protein Name:&quot;Similar to CREB1 Cyclic AMP-responsive element-binding protein 1 (Bos taurus)&quot; AED:0.05 eAED:0.05 QI:0|-1|0|1|-1|1|1|0|278"/>
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      <coils-match>
        <signature ac="Coil" name="Coil">
          <signature-library-release library="COILS" version="2.2.1"/>
        </signature>
        <model-ac>Coil</model-ac>
        <locations>
          <coils-location start="238" end="272">
            <location-fragments>
              <coils-location-fragment start="238" end="272" dc-status="CONTINUOUS"/>
            </location-fragments>
          </coils-location>
        </locations>
      </coils-match>
      <fingerprints-match evalue="2.5E-35" graphscan="I..III">
        <signature ac="PR00041" desc="cAMP response element binding (CREB) protein signature" name="LEUZIPPRCREB">
          <signature-library-release library="PRINTS" version="42.0"/>
        </signature>
        <model-ac>PR00041</model-ac>
        <locations>
          <fingerprints-location motifNumber="1" pvalue="3.35E-9" score="56.52" start="89" end="111">
            <location-fragments>
              <fingerprints-location-fragment start="89" end="111" dc-status="CONTINUOUS"/>
            </location-fragments>
          </fingerprints-location>
          <fingerprints-location motifNumber="4" pvalue="2.75E-10" score="80.0" start="217" end="233">
            <location-fragments>
              <fingerprints-location-fragment start="217" end="233" dc-status="CONTINUOUS"/>
            </location-fragments>
          </fingerprints-location>
          <fingerprints-location motifNumber="5" pvalue="1.17E-13" score="88.57" start="235" end="255">
            <location-fragments>
              <fingerprints-location-fragment start="235" end="255" dc-status="CONTINUOUS"/>
            </location-fragments>
          </fingerprints-location>
          <fingerprints-location motifNumber="6" pvalue="2.13E-10" score="80.74" start="255" end="272">
            <location-fragments>
              <fingerprints-location-fragment start="255" end="272" dc-status="CONTINUOUS"/>
            </location-fragments>
          </fingerprints-location>
        </locations>
      </fingerprints-match>
      <hmmer2-match evalue="2.1E-8" score="43.9">
        <signature ac="SM00338" name="brlzneu">
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            <pathway-xref db="Reactome" id="R-BTA-8874211" name="CREB3 factors activate genes"/>
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            <pathway-xref db="Reactome" id="R-HSA-6796648" name="TP53 Regulates Transcription of DNA Repair Genes"/>
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            <pathway-xref db="Reactome" id="R-GGA-2559582" name="Senescence-Associated Secretory Phenotype (SASP)"/>
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            <pathway-xref db="Reactome" id="R-HSA-9707587" name="Regulation of HMOX1 expression and activity"/>
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            <pathway-xref db="Reactome" id="R-HSA-9609690" name="HCMV Early Events"/>
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      <hmmer3-match evalue="3.5E-28" score="99.0">
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        <model-ac>1dh3A00</model-ac>
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            </location-fragments>
          </hmmer3-location>
        </locations>
      </hmmer3-match>
      <mobidblite-match>
        <signature ac="mobidb-lite" desc="consensus disorder prediction" name="disorder_prediction">
          <signature-library-release library="MOBIDB_LITE" version="2.0"/>
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        <model-ac>mobidb-lite</model-ac>
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          </mobidblite-location>
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      <mobidblite-match>
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      <mobidblite-match>
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      <panther-match evalue="6.4E-55" familyName="CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN B" score="199.1">
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            <pathway-xref db="Reactome" id="R-HSA-2559580" name="Oxidative Stress Induced Senescence"/>
            <pathway-xref db="Reactome" id="R-MMU-2559582" name="Senescence-Associated Secretory Phenotype (SASP)"/>
            <pathway-xref db="Reactome" id="R-RNO-2559580" name="Oxidative Stress Induced Senescence"/>
            <pathway-xref db="Reactome" id="R-RNO-381033" name="ATF6 (ATF6-alpha) activates chaperones"/>
            <pathway-xref db="Reactome" id="R-SCE-2559580" name="Oxidative Stress Induced Senescence"/>
            <pathway-xref db="Reactome" id="R-MMU-199920" name="CREB phosphorylation"/>
            <pathway-xref db="Reactome" id="R-CEL-3214847" name="HATs acetylate histones"/>
            <pathway-xref db="Reactome" id="R-SPO-450341" name="Activation of the AP-1 family of transcription factors"/>
            <pathway-xref db="Reactome" id="R-MMU-983231" name="Factors involved in megakaryocyte development and platelet production"/>
            <pathway-xref db="Reactome" id="R-HSA-442729" name="CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde"/>
            <pathway-xref db="Reactome" id="R-MMU-8874211" name="CREB3 factors activate genes"/>
            <pathway-xref db="Reactome" id="R-RNO-8932339" name="ROS sensing by NFE2L2"/>
            <pathway-xref db="Reactome" id="R-RNO-3214847" name="HATs acetylate histones"/>
            <pathway-xref db="Reactome" id="R-DME-881907" name="Gastrin-CREB signalling pathway via PKC and MAPK"/>
            <pathway-xref db="Reactome" id="R-MMU-9616222" name="Transcriptional regulation of granulopoiesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9673324" name="WNT5:FZD7-mediated leishmania damping"/>
            <pathway-xref db="Reactome" id="R-DME-209425" name="Transcriptional activtion by AP-1 transcription factor"/>
            <pathway-xref db="Reactome" id="R-MMU-442742" name="CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-2559580" name="Oxidative Stress Induced Senescence"/>
            <pathway-xref db="Reactome" id="R-GGA-437986" name="Activated TAK1 mediates Jun kinases (JNK) phosphorylation and activation"/>
            <pathway-xref db="Reactome" id="R-DME-2871796" name="FCERI mediated MAPK activation"/>
            <pathway-xref db="Reactome" id="R-DME-2559580" name="Oxidative Stress Induced Senescence"/>
            <pathway-xref db="Reactome" id="R-HSA-2197563" name="NOTCH2 intracellular domain regulates transcription"/>
            <pathway-xref db="Reactome" id="R-HSA-380994" name="ATF4 activates genes in response to endoplasmic reticulum stress"/>
            <pathway-xref db="Reactome" id="R-HSA-9022692" name="Regulation of MECP2 expression and activity"/>
            <pathway-xref db="Reactome" id="R-HSA-9634638" name="Estrogen-dependent nuclear events downstream of ESR-membrane signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-9634638" name="Estrogen-dependent nuclear events downstream of ESR-membrane signaling"/>
            <pathway-xref db="Reactome" id="R-BTA-2871796" name="FCERI mediated MAPK activation"/>
            <pathway-xref db="Reactome" id="R-MMU-198693" name="AKT phosphorylates targets in the nucleus"/>
            <pathway-xref db="Reactome" id="R-HSA-381033" name="ATF6 (ATF6-alpha) activates chaperones"/>
            <pathway-xref db="Reactome" id="R-HSA-210745" name="Regulation of gene expression in beta cells"/>
            <pathway-xref db="Reactome" id="R-CEL-450341" name="Activation of the AP-1 family of transcription factors"/>
            <pathway-xref db="Reactome" id="R-HSA-2559582" name="Senescence-Associated Secretory Phenotype (SASP)"/>
            <pathway-xref db="Reactome" id="R-HSA-8963889" name="Assembly of active LPL and LIPC lipase complexes"/>
            <pathway-xref db="Reactome" id="R-DME-375165" name="NCAM signaling for neurite out-growth"/>
            <pathway-xref db="Reactome" id="R-HSA-9633012" name="Response of EIF2AK4 (GCN2) to amino acid deficiency"/>
            <pathway-xref db="Reactome" id="R-RNO-199920" name="CREB phosphorylation"/>
            <pathway-xref db="Reactome" id="R-HSA-9022702" name="MECP2 regulates transcription of neuronal ligands"/>
            <pathway-xref db="Reactome" id="R-HSA-8943724" name="Regulation of PTEN gene transcription"/>
            <pathway-xref db="Reactome" id="R-MMU-8932339" name="ROS sensing by NFE2L2"/>
            <pathway-xref db="Reactome" id="R-SCE-2871796" name="FCERI mediated MAPK activation"/>
            <pathway-xref db="Reactome" id="R-SPO-3214847" name="HATs acetylate histones"/>
            <pathway-xref db="Reactome" id="R-DDI-381033" name="ATF6 (ATF6-alpha) activates chaperones"/>
            <pathway-xref db="Reactome" id="R-DME-381753" name="Olfactory Signaling Pathway"/>
            <pathway-xref db="Reactome" id="R-MMU-3214847" name="HATs acetylate histones"/>
            <pathway-xref db="Reactome" id="R-RNO-881907" name="Gastrin-CREB signalling pathway via PKC and MAPK"/>
            <pathway-xref db="Reactome" id="R-RNO-2559582" name="Senescence-Associated Secretory Phenotype (SASP)"/>
            <pathway-xref db="Reactome" id="R-CEL-8874211" name="CREB3 factors activate genes"/>
            <pathway-xref db="Reactome" id="R-HSA-9660821" name="ADORA2B mediated anti-inflammatory cytokines production"/>
            <pathway-xref db="Reactome" id="R-DDI-5632684" name="Hedgehog 'on' state"/>
            <pathway-xref db="Reactome" id="R-MMU-9031628" name="NGF-stimulated transcription"/>
            <pathway-xref db="Reactome" id="R-DME-199920" name="CREB phosphorylation"/>
            <pathway-xref db="Reactome" id="R-RNO-8874211" name="CREB3 factors activate genes"/>
            <pathway-xref db="Reactome" id="R-HSA-9707616" name="Heme signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-8874211" name="CREB3 factors activate genes"/>
            <pathway-xref db="Reactome" id="R-BTA-450341" name="Activation of the AP-1 family of transcription factors"/>
            <pathway-xref db="Reactome" id="R-HSA-5687128" name="MAPK6/MAPK4 signaling"/>
            <pathway-xref db="Reactome" id="R-DME-2559582" name="Senescence-Associated Secretory Phenotype (SASP)"/>
            <pathway-xref db="Reactome" id="R-RNO-442742" name="CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-198693" name="AKT phosphorylates targets in the nucleus"/>
            <pathway-xref db="Reactome" id="R-RNO-450341" name="Activation of the AP-1 family of transcription factors"/>
            <pathway-xref db="Reactome" id="R-HSA-6785807" name="Interleukin-4 and Interleukin-13 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-375165" name="NCAM signaling for neurite out-growth"/>
            <pathway-xref db="Reactome" id="R-HSA-5617472" name="Activation of anterior HOX genes in hindbrain development during early embryogenesis"/>
            <pathway-xref db="Reactome" id="R-MMU-9634638" name="Estrogen-dependent nuclear events downstream of ESR-membrane signaling"/>
          </entry>
          <signature-library-release library="PROSITE_PROFILES" version="2021_01"/>
        </signature>
        <model-ac>PS50217</model-ac>
        <locations>
          <profilescan-location score="11.300234" start="220" end="278">
            <location-fragments>
              <profilescan-location-fragment start="220" end="278" dc-status="CONTINUOUS"/>
            </location-fragments>
            <alignment>ARKREVRLMKNREAARECRNKKKEYIKCLENRVAVLENQNKALIEELKSLKELYTGQKS-----</alignment>
          </profilescan-location>
        </locations>
      </profilescan-match>
      <rpsblast-match>
        <signature ac="cd14690" desc="bZIP_CREB1" name="bZIP_CREB1">
          <signature-library-release library="CDD" version="3.18"/>
        </signature>
        <model-ac>cd14690</model-ac>
        <locations>
          <rpsblast-location evalue="2.39563E-26" score="96.1611" start="222" end="273">
            <location-fragments>
              <rpsblast-location-fragment start="222" end="273" dc-status="CONTINUOUS"/>
            </location-fragments>
            <sites>
              <rpsblast-site description="DNA binding site" numLocations="13">
                <site-locations>
                  <site-location residue="K" start="242" end="242"/>
                  <site-location residue="R" start="235" end="235"/>
                  <site-location residue="L" start="227" end="227"/>
                  <site-location residue="R" start="223" end="223"/>
                  <site-location residue="A" start="234" end="234"/>
                  <site-location residue="K" start="241" end="241"/>
                  <site-location residue="A" start="233" end="233"/>
                  <site-location residue="R" start="238" end="238"/>
                  <site-location residue="K" start="240" end="240"/>
                  <site-location residue="K" start="229" end="229"/>
                  <site-location residue="N" start="230" end="230"/>
                  <site-location residue="R" start="231" end="231"/>
                  <site-location residue="C" start="237" end="237"/>
                </site-locations>
              </rpsblast-site>
              <rpsblast-site description="dimer interface" numLocations="17">
                <site-locations>
                  <site-location residue="Y" start="244" end="244"/>
                  <site-location residue="L" start="266" end="266"/>
                  <site-location residue="L" start="255" end="255"/>
                  <site-location residue="R" start="251" end="251"/>
                  <site-location residue="L" start="272" end="272"/>
                  <site-location residue="V" start="252" end="252"/>
                  <site-location residue="Q" start="258" end="258"/>
                  <site-location residue="K" start="241" end="241"/>
                  <site-location residue="E" start="256" end="256"/>
                  <site-location residue="E" start="249" end="249"/>
                  <site-location residue="E" start="265" end="265"/>
                  <site-location residue="L" start="248" end="248"/>
                  <site-location residue="L" start="269" end="269"/>
                  <site-location residue="N" start="259" end="259"/>
                  <site-location residue="L" start="262" end="262"/>
                  <site-location residue="K" start="270" end="270"/>
                  <site-location residue="Y" start="273" end="273"/>
                </site-locations>
              </rpsblast-site>
            </sites>
          </rpsblast-location>
        </locations>
      </rpsblast-match>
      <superfamilyhmmer3-match evalue="1.55E-12">
        <signature ac="SSF57959" name="Leucine zipper domain">
          <signature-library-release library="SUPERFAMILY" version="1.75"/>
        </signature>
        <model-ac>0053517</model-ac>
        <locations>
          <superfamilyhmmer3-location hmm-length="62" start="222" end="274">
            <location-fragments>
              <superfamilyhmmer3-location-fragment start="222" end="274" dc-status="CONTINUOUS"/>
            </location-fragments>
          </superfamilyhmmer3-location>
        </locations>
      </superfamilyhmmer3-match>
    </matches>
  </protein>
  <protein>
    <sequence md5="45afb7836a2372032c5e8a4cf5bb6738">MMRKHSSHIEAGSSSCCSGTCYCSKKVKVTICVVIWTVIAVIVALILAVIIKAATLQELFERMELGARDDPVFMSATEQEILERSQRLVDAISYRTISFSGTNLSLEAMTDFGTFLERVFPNLHDSDFVTFTPINTYSRLYRIEGTEKTLNPYLLCAHMDVVPEGDFDLWTHDPFDAGIVTESDGQDYIFGRGAIDDKHAVLGIMEALEYKVVNKEQPKRTFYIGFGHDEEVSGYLGAAEISITLEKMLKDNGEELDFLLDEGMFVVADIIPGINVPLIYIGVAEKGWAVVDLDAEGDQVHSSTPPLESSIGILAHGVANMEDNKQPSMFGKGPEIDTLRYAAPHATFLLKMILGNLWLFSGLVSSALELSSQTDSIQRTTTAVTIFNAGVKENVVPSQAHAVVNHRIHPSDNLEDVLELDRENADRVKVTLRDSFPPSEVSSYSNDVIPFQIVVNSALEVFPDAKPVPGLMVANTDTFHYKNLTDKIYRFTPVYNLPEDIARFHGIDERISVDIYSKVVQFYYRLMVNADFDVKIAPTAQVEVKPEEVEEFLEILEESDYESPINNTDSNLLPLTKVMEESDENSANETDSHLMILQDIPEEPNENPSNETDSGLPPSQDILEEDFDAMPVNETYSDMLPLESAPKDLDLYDLTPEEETFSNRTID</sequence>
    <xref id="TCALIF_00447-PA" name="TCALIF_00447-PA protein Name:&quot;Similar to pm20d1.2 Probable carboxypeptidase PM20D1.2 (Danio rerio)&quot; AED:0.10 eAED:0.10 QI:0|-1|0|1|-1|1|1|0|667"/>
    <matches>
      <hmmer3-match evalue="6.2E-25" score="88.1">
        <signature ac="PF01546" desc="Peptidase family M20/M25/M40" name="Peptidase_M20">
          <entry ac="IPR002933" desc="Peptidase M20" name="Peptidase_M20" type="FAMILY">
            <go-xref category="MOLECULAR_FUNCTION" db="GO" id="GO:0016787" name="hydrolase activity"/>
            <pathway-xref db="Reactome" id="R-SCE-174403" name="Glutathione synthesis and recycling"/>
            <pathway-xref db="MetaCyc" id="PWY-8293" name="alazopeptin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-3081" name="L-lysine biosynthesis V"/>
            <pathway-xref db="MetaCyc" id="PWY-6840" name="homoglutathione biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6409" name="pyoverdine I biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7694" name="zwittermicin A biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6984" name="lipoate salvage II"/>
            <pathway-xref db="MetaCyc" id="PWY-8229" name="UDP-3-acetamido-2,3-dideoxy-2-(seryl)amino-alpha-D-glucuronamide biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SSC-5423646" name="Aflatoxin activation and detoxification"/>
            <pathway-xref db="MetaCyc" id="PWY-5846" name="colchicine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9673163" name="Oleoyl-phe metabolism"/>
            <pathway-xref db="MetaCyc" id="PWY-7112" name="4-hydroxy-2-nonenal detoxification"/>
            <pathway-xref db="MetaCyc" id="PWY-7652" name="echinocandin B degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7018" name="paromomycin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7430" name="indole degradation to anthranil and anthranilate"/>
            <pathway-xref db="Reactome" id="R-MMU-9673163" name="Oleoyl-phe metabolism"/>
            <pathway-xref db="MetaCyc" id="PWY-6423" name="hemoglobin degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-5784" name="indole-3-acetate inactivation VIII"/>
            <pathway-xref db="Reactome" id="R-SPO-9673163" name="Oleoyl-phe metabolism"/>
            <pathway-xref db="MetaCyc" id="PWY-4061" name="glutathione-mediated detoxification I"/>
            <pathway-xref db="MetaCyc" id="PWY-5497" name="purine nucleobases degradation II (anaerobic)"/>
            <pathway-xref db="MetaCyc" id="PWY-5692" name="allantoin degradation to glyoxylate II"/>
            <pathway-xref db="MetaCyc" id="PWY-7044" name="5-nitroanthranilate degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7255" name="ergothioneine biosynthesis I (bacteria)"/>
            <pathway-xref db="MetaCyc" id="PWY-601" name="glucosinolate biosynthesis from tryptophan"/>
            <pathway-xref db="Reactome" id="R-MMU-174403" name="Glutathione synthesis and recycling"/>
            <pathway-xref db="Reactome" id="R-HSA-5579007" name="Defective ACY1 causes encephalopathy"/>
            <pathway-xref db="MetaCyc" id="PWY-7901" name="glucosinolate biosynthesis from tyrosine"/>
            <pathway-xref db="Reactome" id="R-SCE-9673163" name="Oleoyl-phe metabolism"/>
            <pathway-xref db="MetaCyc" id="PWY-2941" name="L-lysine biosynthesis II"/>
            <pathway-xref db="MetaCyc" id="PWY-7821" name="tunicamycin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8001" name="felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6842" name="glutathione-mediated detoxification II"/>
            <pathway-xref db="Reactome" id="R-DRE-9673163" name="Oleoyl-phe metabolism"/>
            <pathway-xref db="MetaCyc" id="PWY-8302" name="S-(6-hydroxy-4-methylhexan-4-yl)-L-cysteinylglycine degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-5423646" name="Aflatoxin activation and detoxification"/>
            <pathway-xref db="Reactome" id="R-DDI-5423646" name="Aflatoxin activation and detoxification"/>
            <pathway-xref db="MetaCyc" id="PWY-7403" name="tetramethylpyrazine degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-6899" name="base-degraded thiamine salvage"/>
            <pathway-xref db="Reactome" id="R-MMU-5423646" name="Aflatoxin activation and detoxification"/>
            <pathway-xref db="MetaCyc" id="PWY-7569" name="arginomycin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7559" name="glutathione degradation (DUG pathway - yeast)"/>
            <pathway-xref db="Reactome" id="R-XTR-9673163" name="Oleoyl-phe metabolism"/>
            <pathway-xref db="Reactome" id="R-SPO-174403" name="Glutathione synthesis and recycling"/>
            <pathway-xref db="MetaCyc" id="PWY-7859" name="jasmonoyl-L-isoleucine inactivation"/>
            <pathway-xref db="MetaCyc" id="PWY-7571" name="ferrichrome A biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5154" name="L-arginine biosynthesis III (via N-acetyl-L-citrulline)"/>
            <pathway-xref db="MetaCyc" id="PWY-1187" name="glucosinolate biosynthesis from homomethionine"/>
            <pathway-xref db="MetaCyc" id="PWY-2821" name="glucosinolate biosynthesis from phenylalanine"/>
            <pathway-xref db="MetaCyc" id="PWY-7771" name="butachlor degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7496" name="linuron degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-1822" name="indole-3-acetate activation I"/>
            <pathway-xref db="MetaCyc" id="PWY-8043" name="ophthalmate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-174403" name="Glutathione synthesis and recycling"/>
            <pathway-xref db="MetaCyc" id="PWY-4041" name="gamma-glutamyl cycle"/>
            <pathway-xref db="Reactome" id="R-DDI-9673163" name="Oleoyl-phe metabolism"/>
            <pathway-xref db="Reactome" id="R-RNO-174403" name="Glutathione synthesis and recycling"/>
            <pathway-xref db="MetaCyc" id="PWY-5698" name="allantoin degradation to ureidoglycolate II (ammonia producing)"/>
            <pathway-xref db="MetaCyc" id="PWY-7954" name="tabtoxinine-beta-lactam biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-5423646" name="Aflatoxin activation and detoxification"/>
            <pathway-xref db="MetaCyc" id="PWY-7570" name="blasticidin S biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7850" name="taurine biosynthesis II"/>
          </entry>
          <signature-library-release library="PFAM" version="34.0"/>
        </signature>
        <model-ac>PF01546</model-ac>
        <locations>
          <hmmer3-location env-end="529" env-start="154" post-processed="true" score="88.1" evalue="9.6E-25" hmm-start="1" hmm-end="206" hmm-length="207" hmm-bounds="N_TERMINAL_COMPLETE" start="154" end="528">
            <location-fragments>
              <hmmer3-location-fragment start="154" end="283" dc-status="C_TERMINAL_DISC"/>
              <hmmer3-location-fragment start="425" end="528" dc-status="N_TERMINAL_DISC"/>
            </location-fragments>
          </hmmer3-location>
        </locations>
      </hmmer3-match>
      <hmmer3-match evalue="1.8E-30" score="107.9">
        <signature ac="G3DSA:3.40.630.10" name="Zn peptidases">
          <signature-library-release library="GENE3D" version="4.3.0"/>
        </signature>
        <model-ac>1q7lA00</model-ac>
        <locations>
          <hmmer3-location env-end="291" env-start="74" post-processed="true" score="107.1" evalue="3.1E-30" hmm-start="14" hmm-end="179" hmm-length="198" hmm-bounds="N_TERMINAL_COMPLETE" start="74" end="288">
            <location-fragments>
              <hmmer3-location-fragment start="74" end="288" dc-status="CONTINUOUS"/>
            </location-fragments>
          </hmmer3-location>
        </locations>
      </hmmer3-match>
      <hmmer3-match evalue="1.0E-13" score="51.1">
        <signature ac="PF07687" desc="Peptidase dimerisation domain" name="M20_dimer">
          <entry ac="IPR011650" desc="Peptidase M20, dimerisation domain" name="Peptidase_M20_dimer" type="DOMAIN">
            <pathway-xref db="Reactome" id="R-SCE-174403" name="Glutathione synthesis and recycling"/>
            <pathway-xref db="MetaCyc" id="PWY-8293" name="alazopeptin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-3081" name="L-lysine biosynthesis V"/>
            <pathway-xref db="MetaCyc" id="PWY-6409" name="pyoverdine I biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7694" name="zwittermicin A biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6984" name="lipoate salvage II"/>
            <pathway-xref db="MetaCyc" id="PWY-8229" name="UDP-3-acetamido-2,3-dideoxy-2-(seryl)amino-alpha-D-glucuronamide biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SSC-5423646" name="Aflatoxin activation and detoxification"/>
            <pathway-xref db="MetaCyc" id="PWY-5846" name="colchicine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9673163" name="Oleoyl-phe metabolism"/>
            <pathway-xref db="MetaCyc" id="PWY-7112" name="4-hydroxy-2-nonenal detoxification"/>
            <pathway-xref db="MetaCyc" id="PWY-7652" name="echinocandin B degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7018" name="paromomycin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7430" name="indole degradation to anthranil and anthranilate"/>
            <pathway-xref db="Reactome" id="R-MMU-9673163" name="Oleoyl-phe metabolism"/>
            <pathway-xref db="MetaCyc" id="PWY-6423" name="hemoglobin degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-5784" name="indole-3-acetate inactivation VIII"/>
            <pathway-xref db="Reactome" id="R-SPO-9673163" name="Oleoyl-phe metabolism"/>
            <pathway-xref db="MetaCyc" id="PWY-4061" name="glutathione-mediated detoxification I"/>
            <pathway-xref db="MetaCyc" id="PWY-5497" name="purine nucleobases degradation II (anaerobic)"/>
            <pathway-xref db="MetaCyc" id="PWY-7044" name="5-nitroanthranilate degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-601" name="glucosinolate biosynthesis from tryptophan"/>
            <pathway-xref db="Reactome" id="R-MMU-174403" name="Glutathione synthesis and recycling"/>
            <pathway-xref db="Reactome" id="R-HSA-5579007" name="Defective ACY1 causes encephalopathy"/>
            <pathway-xref db="MetaCyc" id="PWY-7901" name="glucosinolate biosynthesis from tyrosine"/>
            <pathway-xref db="Reactome" id="R-SCE-9673163" name="Oleoyl-phe metabolism"/>
            <pathway-xref db="MetaCyc" id="PWY-2941" name="L-lysine biosynthesis II"/>
            <pathway-xref db="MetaCyc" id="PWY-7821" name="tunicamycin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8001" name="felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6842" name="glutathione-mediated detoxification II"/>
            <pathway-xref db="Reactome" id="R-DRE-9673163" name="Oleoyl-phe metabolism"/>
            <pathway-xref db="MetaCyc" id="PWY-8302" name="S-(6-hydroxy-4-methylhexan-4-yl)-L-cysteinylglycine degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-5423646" name="Aflatoxin activation and detoxification"/>
            <pathway-xref db="Reactome" id="R-DDI-5423646" name="Aflatoxin activation and detoxification"/>
            <pathway-xref db="MetaCyc" id="PWY-7403" name="tetramethylpyrazine degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-6899" name="base-degraded thiamine salvage"/>
            <pathway-xref db="Reactome" id="R-MMU-5423646" name="Aflatoxin activation and detoxification"/>
            <pathway-xref db="MetaCyc" id="PWY-7569" name="arginomycin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7559" name="glutathione degradation (DUG pathway - yeast)"/>
            <pathway-xref db="Reactome" id="R-XTR-9673163" name="Oleoyl-phe metabolism"/>
            <pathway-xref db="Reactome" id="R-SPO-174403" name="Glutathione synthesis and recycling"/>
            <pathway-xref db="MetaCyc" id="PWY-7859" name="jasmonoyl-L-isoleucine inactivation"/>
            <pathway-xref db="MetaCyc" id="PWY-7571" name="ferrichrome A biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5154" name="L-arginine biosynthesis III (via N-acetyl-L-citrulline)"/>
            <pathway-xref db="MetaCyc" id="PWY-1187" name="glucosinolate biosynthesis from homomethionine"/>
            <pathway-xref db="MetaCyc" id="PWY-2821" name="glucosinolate biosynthesis from phenylalanine"/>
            <pathway-xref db="MetaCyc" id="PWY-7771" name="butachlor degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7496" name="linuron degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-1822" name="indole-3-acetate activation I"/>
            <pathway-xref db="Reactome" id="R-HSA-174403" name="Glutathione synthesis and recycling"/>
            <pathway-xref db="MetaCyc" id="PWY-4041" name="gamma-glutamyl cycle"/>
            <pathway-xref db="Reactome" id="R-DDI-9673163" name="Oleoyl-phe metabolism"/>
            <pathway-xref db="Reactome" id="R-RNO-174403" name="Glutathione synthesis and recycling"/>
            <pathway-xref db="MetaCyc" id="PWY-5698" name="allantoin degradation to ureidoglycolate II (ammonia producing)"/>
            <pathway-xref db="MetaCyc" id="PWY-7954" name="tabtoxinine-beta-lactam biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-5423646" name="Aflatoxin activation and detoxification"/>
            <pathway-xref db="MetaCyc" id="PWY-7570" name="blasticidin S biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7850" name="taurine biosynthesis II"/>
          </entry>
          <signature-library-release library="PFAM" version="34.0"/>
        </signature>
        <model-ac>PF07687</model-ac>
        <locations>
          <hmmer3-location env-end="431" env-start="283" post-processed="true" score="49.7" evalue="3.0E-13" hmm-start="2" hmm-end="100" hmm-length="109" hmm-bounds="INCOMPLETE" start="284" end="424">
            <location-fragments>
              <hmmer3-location-fragment start="284" end="424" dc-status="CONTINUOUS"/>
            </location-fragments>
          </hmmer3-location>
        </locations>
      </hmmer3-match>
      <hmmer3-match evalue="6.5E-12" score="47.0">
        <signature ac="G3DSA:1.10.150.900" name="">
          <signature-library-release library="GENE3D" version="4.3.0"/>
        </signature>
        <model-ac>1q7lB01</model-ac>
        <locations>
          <hmmer3-location env-end="531" env-start="450" post-processed="true" score="44.7" evalue="3.5E-11" hmm-start="14" hmm-end="76" hmm-length="81" hmm-bounds="COMPLETE" start="450" end="531">
            <location-fragments>
              <hmmer3-location-fragment start="450" end="531" dc-status="CONTINUOUS"/>
            </location-fragments>
          </hmmer3-location>
        </locations>
      </hmmer3-match>
      <hmmer3-match evalue="2.7E-15" score="42.8">
        <signature ac="G3DSA:3.30.70.360" name="">
          <signature-library-release library="GENE3D" version="4.3.0"/>
        </signature>
        <model-ac>2rb7A02</model-ac>
        <locations>
          <hmmer3-location env-end="0" env-start="0" post-processed="true" score="42.8" evalue="1.7E-10" hmm-start="0" hmm-end="0" hmm-length="107" hmm-bounds="INCOMPLETE" start="289" end="433">
            <location-fragments>
              <hmmer3-location-fragment start="289" end="325" dc-status="C_TERMINAL_DISC"/>
              <hmmer3-location-fragment start="371" end="433" dc-status="N_TERMINAL_DISC"/>
            </location-fragments>
          </hmmer3-location>
        </locations>
      </hmmer3-match>
      <hmmer3-match-with-sites evalue="1.1E-70" score="234.7">
        <signature ac="PIRSR037217-2" name="PIRSR037217-2">
          <signature-library-release library="PIRSR" version="2021_02"/>
        </signature>
        <model-ac>PIRSR037217-2</model-ac>
        <locations>
          <hmmer3-location-with-sites env-end="2" env-start="1" score="234.7" evalue="1.1E-70" hmm-start="106" hmm-end="423" hmm-length="568" hmm-bounds="COMPLETE" start="107" end="426">
            <location-fragments>
              <hmmer3-location-fragment-with-sites start="107" end="426" dc-status="CONTINUOUS"/>
            </location-fragments>
            <sites>
              <hmmer3-site description="Zinc 2." numLocations="1">
                <site-locations>
                  <site-location residue="D" start="196" end="196"/>
                </site-locations>
                <group>2</group>
                <hmmEnd>190</hmmEnd>
                <hmmStart>190</hmmStart>
                <label>METAL</label>
              </hmmer3-site>
              <hmmer3-site description="Zinc 1." numLocations="1">
                <site-locations>
                  <site-location residue="D" start="196" end="196"/>
                </site-locations>
                <group>2</group>
                <hmmEnd>190</hmmEnd>
                <hmmStart>190</hmmStart>
                <label>METAL</label>
              </hmmer3-site>
            </sites>
          </hmmer3-location-with-sites>
        </locations>
      </hmmer3-match-with-sites>
      <mobidblite-match>
        <signature ac="mobidb-lite" desc="consensus disorder prediction" name="disorder_prediction">
          <signature-library-release library="MOBIDB_LITE" version="2.0"/>
        </signature>
        <model-ac>mobidb-lite</model-ac>
        <locations>
          <mobidblite-location sequence-feature="" start="581" end="667">
            <location-fragments>
              <mobidblite-location-fragment start="581" end="667" dc-status="CONTINUOUS"/>
            </location-fragments>
          </mobidblite-location>
        </locations>
      </mobidblite-match>
      <mobidblite-match>
        <signature ac="mobidb-lite" desc="consensus disorder prediction" name="disorder_prediction">
          <signature-library-release library="MOBIDB_LITE" version="2.0"/>
        </signature>
        <model-ac>mobidb-lite</model-ac>
        <locations>
          <mobidblite-location sequence-feature="Polar" start="603" end="617">
            <location-fragments>
              <mobidblite-location-fragment start="603" end="617" dc-status="CONTINUOUS"/>
            </location-fragments>
          </mobidblite-location>
        </locations>
      </mobidblite-match>
      <panther-match evalue="2.7E-141" familyName="N-FATTY-ACYL-AMINO ACID SYNTHASE/HYDROLASE PM20D1" score="483.4">
        <signature ac="PTHR45962" name="N-FATTY-ACYL-AMINO ACID SYNTHASE/HYDROLASE PM20D1">
          <signature-library-release library="PANTHER" version="15.0"/>
        </signature>
        <model-ac>PTHR45962</model-ac>
        <locations>
          <panther-location env-start="25" env-end="548" hmm-start="8" hmm-end="502" hmm-length="506" hmm-bounds="INCOMPLETE" start="35" end="533">
            <location-fragments>
              <panther-location-fragment start="35" end="533" dc-status="CONTINUOUS"/>
            </location-fragments>
          </panther-location>
        </locations>
      </panther-match>
      <superfamilyhmmer3-match evalue="9.29E-38">
        <signature ac="SSF53187" name="Zn-dependent exopeptidases">
          <signature-library-release library="SUPERFAMILY" version="1.75"/>
        </signature>
        <model-ac>0047971</model-ac>
        <locations>
          <superfamilyhmmer3-location hmm-length="273" start="86" end="529">
            <location-fragments>
              <superfamilyhmmer3-location-fragment start="86" end="265" dc-status="C_TERMINAL_DISC"/>
              <superfamilyhmmer3-location-fragment start="442" end="529" dc-status="N_TERMINAL_DISC"/>
            </location-fragments>
          </superfamilyhmmer3-location>
        </locations>
      </superfamilyhmmer3-match>
      <superfamilyhmmer3-match evalue="1.16E-7">
        <signature ac="SSF55031" name="Bacterial exopeptidase dimerisation domain">
          <entry ac="IPR036264" desc="Bacterial exopeptidase dimerisation domain" name="Bact_exopeptidase_dim_dom" type="HOMOLOGOUS_SUPERFAMILY">
            <pathway-xref db="MetaCyc" id="PWY-8293" name="alazopeptin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-3081" name="L-lysine biosynthesis V"/>
            <pathway-xref db="MetaCyc" id="PWY-6840" name="homoglutathione biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6409" name="pyoverdine I biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7694" name="zwittermicin A biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6984" name="lipoate salvage II"/>
            <pathway-xref db="MetaCyc" id="PWY-8229" name="UDP-3-acetamido-2,3-dideoxy-2-(seryl)amino-alpha-D-glucuronamide biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SSC-5423646" name="Aflatoxin activation and detoxification"/>
            <pathway-xref db="MetaCyc" id="PWY-5846" name="colchicine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9673163" name="Oleoyl-phe metabolism"/>
            <pathway-xref db="MetaCyc" id="PWY-7112" name="4-hydroxy-2-nonenal detoxification"/>
            <pathway-xref db="MetaCyc" id="PWY-7652" name="echinocandin B degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7018" name="paromomycin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7430" name="indole degradation to anthranil and anthranilate"/>
            <pathway-xref db="Reactome" id="R-MMU-9673163" name="Oleoyl-phe metabolism"/>
            <pathway-xref db="MetaCyc" id="PWY-6423" name="hemoglobin degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-5784" name="indole-3-acetate inactivation VIII"/>
            <pathway-xref db="Reactome" id="R-SPO-9673163" name="Oleoyl-phe metabolism"/>
            <pathway-xref db="MetaCyc" id="PWY-4061" name="glutathione-mediated detoxification I"/>
            <pathway-xref db="MetaCyc" id="PWY-5497" name="purine nucleobases degradation II (anaerobic)"/>
            <pathway-xref db="MetaCyc" id="PWY-5692" name="allantoin degradation to glyoxylate II"/>
            <pathway-xref db="MetaCyc" id="PWY-7255" name="ergothioneine biosynthesis I (bacteria)"/>
            <pathway-xref db="MetaCyc" id="PWY-601" name="glucosinolate biosynthesis from tryptophan"/>
            <pathway-xref db="Reactome" id="R-HSA-5579007" name="Defective ACY1 causes encephalopathy"/>
            <pathway-xref db="MetaCyc" id="PWY-7901" name="glucosinolate biosynthesis from tyrosine"/>
            <pathway-xref db="Reactome" id="R-SCE-9673163" name="Oleoyl-phe metabolism"/>
            <pathway-xref db="MetaCyc" id="PWY-2941" name="L-lysine biosynthesis II"/>
            <pathway-xref db="MetaCyc" id="PWY-7821" name="tunicamycin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8001" name="felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6842" name="glutathione-mediated detoxification II"/>
            <pathway-xref db="Reactome" id="R-DRE-9673163" name="Oleoyl-phe metabolism"/>
            <pathway-xref db="MetaCyc" id="PWY-8302" name="S-(6-hydroxy-4-methylhexan-4-yl)-L-cysteinylglycine degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-5423646" name="Aflatoxin activation and detoxification"/>
            <pathway-xref db="Reactome" id="R-DDI-5423646" name="Aflatoxin activation and detoxification"/>
            <pathway-xref db="MetaCyc" id="PWY-7403" name="tetramethylpyrazine degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-6899" name="base-degraded thiamine salvage"/>
            <pathway-xref db="Reactome" id="R-MMU-5423646" name="Aflatoxin activation and detoxification"/>
            <pathway-xref db="MetaCyc" id="PWY-7569" name="arginomycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-XTR-9673163" name="Oleoyl-phe metabolism"/>
            <pathway-xref db="MetaCyc" id="PWY-7859" name="jasmonoyl-L-isoleucine inactivation"/>
            <pathway-xref db="MetaCyc" id="PWY-7571" name="ferrichrome A biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5154" name="L-arginine biosynthesis III (via N-acetyl-L-citrulline)"/>
            <pathway-xref db="MetaCyc" id="PWY-1187" name="glucosinolate biosynthesis from homomethionine"/>
            <pathway-xref db="MetaCyc" id="PWY-2821" name="glucosinolate biosynthesis from phenylalanine"/>
            <pathway-xref db="MetaCyc" id="PWY-7771" name="butachlor degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7496" name="linuron degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-1822" name="indole-3-acetate activation I"/>
            <pathway-xref db="MetaCyc" id="PWY-8043" name="ophthalmate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DDI-9673163" name="Oleoyl-phe metabolism"/>
            <pathway-xref db="MetaCyc" id="PWY-5698" name="allantoin degradation to ureidoglycolate II (ammonia producing)"/>
            <pathway-xref db="MetaCyc" id="PWY-7954" name="tabtoxinine-beta-lactam biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-5423646" name="Aflatoxin activation and detoxification"/>
            <pathway-xref db="MetaCyc" id="PWY-7570" name="blasticidin S biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7850" name="taurine biosynthesis II"/>
          </entry>
          <signature-library-release library="SUPERFAMILY" version="1.75"/>
        </signature>
        <model-ac>0050177</model-ac>
        <locations>
          <superfamilyhmmer3-location hmm-length="113" start="295" end="429">
            <location-fragments>
              <superfamilyhmmer3-location-fragment start="380" end="429" dc-status="N_TERMINAL_DISC"/>
              <superfamilyhmmer3-location-fragment start="295" end="334" dc-status="C_TERMINAL_DISC"/>
            </location-fragments>
          </superfamilyhmmer3-location>
        </locations>
      </superfamilyhmmer3-match>
    </matches>
  </protein>
  <protein>
    <sequence md5="9d972df6209ca54c7e86340ae880eb00">MFVSLPAVDVVAEAGTVQEFKSEPCPVVLLNRRVLCPVAIMSLVGLGLGDLDETSYNEKYWIPLRGMLEIIFHQPAGSYQPVSYEETYTLIYKCVSMRSAERLFRDIVQFVESVIQGWQIGLERVSGSPTLFVEAFTKTLEQYFHATSTLLPVCTYLDKSYVKIRIGSTMELFLNGVFTRGIQRENIQCFLKLLSEARSQPFTISPQVMQRSVQYLHRLDASLVSLDWELFSAFLTNVRPAMLECDLEAQIEADRKLQAELRESGFASGESKSRKRIFDADH</sequence>
    <xref id="TCALIF_00078-PA" name="TCALIF_00078-PA protein Name:&quot;Similar to Cacul1 CDK2-associated and cullin domain-containing protein 1 (Mus musculus)&quot; AED:0.01 eAED:0.01 QI:44|1|0.5|1|1|1|2|0|282"/>
    <matches>
      <hmmer3-match evalue="1.8E-13" score="53.1">
        <signature ac="G3DSA:1.20.1310.10" name="Cullin Repeats">
          <signature-library-release library="GENE3D" version="4.3.0"/>
        </signature>
        <model-ac>4a64A01</model-ac>
        <locations>
          <hmmer3-location env-end="175" env-start="51" post-processed="true" score="52.5" evalue="2.9E-13" hmm-start="7" hmm-end="114" hmm-length="132" hmm-bounds="COMPLETE" start="51" end="175">
            <location-fragments>
              <hmmer3-location-fragment start="51" end="175" dc-status="CONTINUOUS"/>
            </location-fragments>
          </hmmer3-location>
        </locations>
      </hmmer3-match>
      <hmmer3-match evalue="2.4E-12" score="46.3">
        <signature ac="PF00888" desc="Cullin family" name="Cullin">
          <entry ac="IPR001373" desc="Cullin, N-terminal" name="Cullin_N" type="DOMAIN">
            <go-xref category="BIOLOGICAL_PROCESS" db="GO" id="GO:0006511" name="ubiquitin-dependent protein catabolic process"/>
            <go-xref category="MOLECULAR_FUNCTION" db="GO" id="GO:0031625" name="ubiquitin protein ligase binding"/>
            <pathway-xref db="Reactome" id="R-DDI-917937" name="Iron uptake and transport"/>
            <pathway-xref db="Reactome" id="R-CEL-195253" name="Degradation of beta-catenin by the destruction complex"/>
            <pathway-xref db="Reactome" id="R-XTR-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-174184" name="Cdc20:Phospho-APC/C mediated degradation of Cyclin A"/>
            <pathway-xref db="Reactome" id="R-HSA-2565942" name="Regulation of PLK1 Activity at G2/M Transition"/>
            <pathway-xref db="Reactome" id="R-MMU-1170546" name="Prolactin receptor signaling"/>
            <pathway-xref db="Reactome" id="R-DDI-174048" name="APC/C:Cdc20 mediated degradation of Cyclin B"/>
            <pathway-xref db="Reactome" id="R-HSA-187577" name="SCF(Skp2)-mediated degradation of p27/p21"/>
            <pathway-xref db="Reactome" id="R-MMU-6782135" name="Dual incision in TC-NER"/>
            <pathway-xref db="Reactome" id="R-MMU-2565942" name="Regulation of PLK1 Activity at G2/M Transition"/>
            <pathway-xref db="Reactome" id="R-DDI-8951664" name="Neddylation"/>
            <pathway-xref db="Reactome" id="R-HSA-1170546" name="Prolactin receptor signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-6782135" name="Dual incision in TC-NER"/>
            <pathway-xref db="Reactome" id="R-RNO-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-5610780" name="Degradation of GLI1 by the proteasome"/>
            <pathway-xref db="Reactome" id="R-MMU-1234176" name="Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha"/>
            <pathway-xref db="Reactome" id="R-HSA-174113" name="SCF-beta-TrCP mediated degradation of Emi1"/>
            <pathway-xref db="Reactome" id="R-HSA-9010553" name="Regulation of expression of SLITs and ROBOs"/>
            <pathway-xref db="Reactome" id="R-MMU-8863795" name="Downregulation of ERBB2 signaling"/>
            <pathway-xref db="Reactome" id="R-DDI-8854050" name="FBXL7 down-regulates AURKA during mitotic entry and in early mitosis"/>
            <pathway-xref db="Reactome" id="R-DME-209461" name="Ubiquitination and degradation of phosphorylated ARM"/>
            <pathway-xref db="Reactome" id="R-DDI-179409" name="APC-Cdc20 mediated degradation of Nek2A"/>
            <pathway-xref db="Reactome" id="R-DDI-68949" name="Orc1 removal from chromatin"/>
            <pathway-xref db="Reactome" id="R-MMU-5632684" name="Hedgehog 'on' state"/>
            <pathway-xref db="Reactome" id="R-DDI-9013422" name="RHOBTB1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-2467813" name="Separation of Sister Chromatids"/>
            <pathway-xref db="Reactome" id="R-MMU-110314" name="Recognition of DNA damage by PCNA-containing replication complex"/>
            <pathway-xref db="Reactome" id="R-DDI-174084" name="Autodegradation of Cdh1 by Cdh1:APC/C"/>
            <pathway-xref db="Reactome" id="R-DME-8939902" name="Regulation of RUNX2 expression and activity"/>
            <pathway-xref db="Reactome" id="R-DME-5610780" name="Degradation of GLI1 by the proteasome"/>
            <pathway-xref db="Reactome" id="R-RNO-8951664" name="Neddylation"/>
            <pathway-xref db="Reactome" id="R-HSA-2467813" name="Separation of Sister Chromatids"/>
            <pathway-xref db="Reactome" id="R-MMU-174178" name="APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1"/>
            <pathway-xref db="Reactome" id="R-DME-187577" name="SCF(Skp2)-mediated degradation of p27/p21"/>
            <pathway-xref db="Reactome" id="R-HSA-400253" name="Circadian Clock"/>
            <pathway-xref db="Reactome" id="R-RNO-5658442" name="Regulation of RAS by GAPs"/>
            <pathway-xref db="Reactome" id="R-SPO-5696395" name="Formation of Incision Complex in GG-NER"/>
            <pathway-xref db="Reactome" id="R-RNO-9013422" name="RHOBTB1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-141430" name="Inactivation of APC/C via direct inhibition of the APC/C complex"/>
            <pathway-xref db="Reactome" id="R-SPO-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-381038" name="XBP1(S) activates chaperone genes"/>
            <pathway-xref db="Reactome" id="R-DDI-5696395" name="Formation of Incision Complex in GG-NER"/>
            <pathway-xref db="Reactome" id="R-MMU-9020702" name="Interleukin-1 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-8863795" name="Downregulation of ERBB2 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-8863795" name="Downregulation of ERBB2 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-9706019" name="RHOBTB3 ATPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-5607764" name="CLEC7A (Dectin-1) signaling"/>
            <pathway-xref db="Reactome" id="R-CEL-917937" name="Iron uptake and transport"/>
            <pathway-xref db="Reactome" id="R-CEL-6782210" name="Gap-filling DNA repair synthesis and ligation in TC-NER"/>
            <pathway-xref db="Reactome" id="R-HSA-5610780" name="Degradation of GLI1 by the proteasome"/>
            <pathway-xref db="Reactome" id="R-HSA-1234176" name="Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha"/>
            <pathway-xref db="Reactome" id="R-SPO-917937" name="Iron uptake and transport"/>
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          <signature-library-release library="PFAM" version="34.0"/>
        </signature>
        <model-ac>PF00888</model-ac>
        <locations>
          <hmmer3-location env-end="245" env-start="61" post-processed="true" score="46.1" evalue="2.9E-12" hmm-start="4" hmm-end="161" hmm-length="619" hmm-bounds="INCOMPLETE" start="64" end="220">
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              <hmmer3-location-fragment start="64" end="220" dc-status="CONTINUOUS"/>
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          </hmmer3-location>
        </locations>
      </hmmer3-match>
      <panther-match evalue="2.0E-45" familyName="CDK2-ASSOCIATED AND CULLIN DOMAIN-CONTAINING PROTEIN 1" score="167.3">
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              <panther-location-fragment start="53" end="280" dc-status="CONTINUOUS"/>
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          </panther-location>
        </locations>
      </panther-match>
      <superfamilyhmmer3-match evalue="2.28E-18">
        <signature ac="SSF74788" name="Cullin repeat-like">
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            <pathway-xref db="Reactome" id="R-DME-209461" name="Ubiquitination and degradation of phosphorylated ARM"/>
            <pathway-xref db="Reactome" id="R-DDI-68949" name="Orc1 removal from chromatin"/>
            <pathway-xref db="Reactome" id="R-MMU-5632684" name="Hedgehog 'on' state"/>
            <pathway-xref db="Reactome" id="R-DDI-9013422" name="RHOBTB1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-110314" name="Recognition of DNA damage by PCNA-containing replication complex"/>
            <pathway-xref db="Reactome" id="R-DME-8939902" name="Regulation of RUNX2 expression and activity"/>
            <pathway-xref db="Reactome" id="R-DME-5610780" name="Degradation of GLI1 by the proteasome"/>
            <pathway-xref db="Reactome" id="R-RNO-8951664" name="Neddylation"/>
            <pathway-xref db="Reactome" id="R-DDI-264876" name="Insulin processing"/>
            <pathway-xref db="Reactome" id="R-DME-187577" name="SCF(Skp2)-mediated degradation of p27/p21"/>
            <pathway-xref db="Reactome" id="R-HSA-400253" name="Circadian Clock"/>
            <pathway-xref db="Reactome" id="R-RNO-5658442" name="Regulation of RAS by GAPs"/>
            <pathway-xref db="Reactome" id="R-SPO-5696395" name="Formation of Incision Complex in GG-NER"/>
            <pathway-xref db="Reactome" id="R-HSA-5218920" name="VEGFR2 mediated vascular permeability"/>
            <pathway-xref db="Reactome" id="R-RNO-9013422" name="RHOBTB1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-SPO-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-DDI-6811438" name="Intra-Golgi traffic"/>
            <pathway-xref db="Reactome" id="R-DDI-5696395" name="Formation of Incision Complex in GG-NER"/>
            <pathway-xref db="Reactome" id="R-MMU-9020702" name="Interleukin-1 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-8863795" name="Downregulation of ERBB2 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-5674400" name="Constitutive Signaling by AKT1 E17K in Cancer"/>
            <pathway-xref db="Reactome" id="R-HSA-8863795" name="Downregulation of ERBB2 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-9706019" name="RHOBTB3 ATPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-5607764" name="CLEC7A (Dectin-1) signaling"/>
            <pathway-xref db="Reactome" id="R-CEL-917937" name="Iron uptake and transport"/>
            <pathway-xref db="Reactome" id="R-CEL-6782210" name="Gap-filling DNA repair synthesis and ligation in TC-NER"/>
            <pathway-xref db="Reactome" id="R-SPO-264876" name="Insulin processing"/>
            <pathway-xref db="Reactome" id="R-HSA-5610780" name="Degradation of GLI1 by the proteasome"/>
            <pathway-xref db="Reactome" id="R-HSA-1234176" name="Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha"/>
            <pathway-xref db="Reactome" id="R-SPO-917937" name="Iron uptake and transport"/>
            <pathway-xref db="Reactome" id="R-XTR-4641258" name="Degradation of DVL"/>
            <pathway-xref db="Reactome" id="R-SPO-6781823" name="Formation of TC-NER Pre-Incision Complex"/>
            <pathway-xref db="Reactome" id="R-RNO-5632684" name="Hedgehog 'on' state"/>
            <pathway-xref db="Reactome" id="R-HSA-5632684" name="Hedgehog 'on' state"/>
            <pathway-xref db="Reactome" id="R-DRE-5620916" name="VxPx cargo-targeting to cilium"/>
            <pathway-xref db="Reactome" id="R-CEL-8932339" name="ROS sensing by NFE2L2"/>
            <pathway-xref db="Reactome" id="R-HSA-69231" name="Cyclin D associated events in G1"/>
            <pathway-xref db="Reactome" id="R-CEL-5696394" name="DNA Damage Recognition in GG-NER"/>
            <pathway-xref db="Reactome" id="R-SCE-8854050" name="FBXL7 down-regulates AURKA during mitotic entry and in early mitosis"/>
            <pathway-xref db="Reactome" id="R-CEL-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-2871837" name="FCERI mediated NF-kB activation"/>
            <pathway-xref db="Reactome" id="R-CEL-6811438" name="Intra-Golgi traffic"/>
            <pathway-xref db="Reactome" id="R-DME-6807878" name="COPI-mediated anterograde transport"/>
            <pathway-xref db="Reactome" id="R-RNO-9013418" name="RHOBTB2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-202424" name="Downstream TCR signaling"/>
            <pathway-xref db="Reactome" id="R-CEL-6781823" name="Formation of TC-NER Pre-Incision Complex"/>
            <pathway-xref db="Reactome" id="R-HSA-8854050" name="FBXL7 down-regulates AURKA during mitotic entry and in early mitosis"/>
            <pathway-xref db="Reactome" id="R-HSA-1169091" name="Activation of NF-kappaB in B cells"/>
            <pathway-xref db="Reactome" id="R-HSA-5607764" name="CLEC7A (Dectin-1) signaling"/>
            <pathway-xref db="Reactome" id="R-SCE-264876" name="Insulin processing"/>
            <pathway-xref db="Reactome" id="R-HSA-68949" name="Orc1 removal from chromatin"/>
            <pathway-xref db="Reactome" id="R-RNO-8932339" name="ROS sensing by NFE2L2"/>
            <pathway-xref db="Reactome" id="R-MMU-8854050" name="FBXL7 down-regulates AURKA during mitotic entry and in early mitosis"/>
            <pathway-xref db="Reactome" id="R-HSA-5658442" name="Regulation of RAS by GAPs"/>
            <pathway-xref db="Reactome" id="R-HSA-9705462" name="Inactivation of CSF3 (G-CSF) signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9013422" name="RHOBTB1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-CEL-68949" name="Orc1 removal from chromatin"/>
            <pathway-xref db="Reactome" id="R-SPO-6782210" name="Gap-filling DNA repair synthesis and ligation in TC-NER"/>
            <pathway-xref db="Reactome" id="R-HSA-6811440" name="Retrograde transport at the Trans-Golgi-Network"/>
            <pathway-xref db="Reactome" id="R-CEL-1234176" name="Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha"/>
            <pathway-xref db="Reactome" id="R-MMU-9705462" name="Inactivation of CSF3 (G-CSF) signaling"/>
            <pathway-xref db="Reactome" id="R-DDI-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-264876" name="Insulin processing"/>
            <pathway-xref db="Reactome" id="R-HSA-5696400" name="Dual Incision in GG-NER"/>
            <pathway-xref db="Reactome" id="R-DDI-6782135" name="Dual incision in TC-NER"/>
            <pathway-xref db="Reactome" id="R-XTR-5632684" name="Hedgehog 'on' state"/>
            <pathway-xref db="Reactome" id="R-HSA-5696395" name="Formation of Incision Complex in GG-NER"/>
            <pathway-xref db="Reactome" id="R-HSA-195253" name="Degradation of beta-catenin by the destruction complex"/>
            <pathway-xref db="Reactome" id="R-MMU-8951664" name="Neddylation"/>
            <pathway-xref db="Reactome" id="R-CEL-110314" name="Recognition of DNA damage by PCNA-containing replication complex"/>
            <pathway-xref db="Reactome" id="R-CEL-8951664" name="Neddylation"/>
            <pathway-xref db="Reactome" id="R-HSA-9013418" name="RHOBTB2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-CEL-69231" name="Cyclin D associated events in G1"/>
            <pathway-xref db="Reactome" id="R-MMU-8932339" name="ROS sensing by NFE2L2"/>
            <pathway-xref db="Reactome" id="R-MMU-8939902" name="Regulation of RUNX2 expression and activity"/>
            <pathway-xref db="Reactome" id="R-SCE-68949" name="Orc1 removal from chromatin"/>
            <pathway-xref db="Reactome" id="R-MMU-5218920" name="VEGFR2 mediated vascular permeability"/>
            <pathway-xref db="Reactome" id="R-RNO-9705462" name="Inactivation of CSF3 (G-CSF) signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-9013418" name="RHOBTB2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DME-5620916" name="VxPx cargo-targeting to cilium"/>
            <pathway-xref db="Reactome" id="R-MMU-68949" name="Orc1 removal from chromatin"/>
            <pathway-xref db="Reactome" id="R-SCE-8951664" name="Neddylation"/>
            <pathway-xref db="Reactome" id="R-CEL-9706019" name="RHOBTB3 ATPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-5684264" name="MAP3K8 (TPL2)-dependent MAPK1/3 activation"/>
            <pathway-xref db="Reactome" id="R-MMU-5658442" name="Regulation of RAS by GAPs"/>
            <pathway-xref db="Reactome" id="R-HSA-8939902" name="Regulation of RUNX2 expression and activity"/>
            <pathway-xref db="Reactome" id="R-HSA-2122947" name="NOTCH1 Intracellular Domain Regulates Transcription"/>
            <pathway-xref db="Reactome" id="R-SCE-174113" name="SCF-beta-TrCP mediated degradation of Emi1"/>
            <pathway-xref db="Reactome" id="R-RNO-5620916" name="VxPx cargo-targeting to cilium"/>
            <pathway-xref db="Reactome" id="R-HSA-6781827" name="Transcription-Coupled Nucleotide Excision Repair (TC-NER)"/>
            <pathway-xref db="Reactome" id="R-CEL-4641258" name="Degradation of DVL"/>
            <pathway-xref db="Reactome" id="R-MMU-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-6804757" name="Regulation of TP53 Degradation"/>
            <pathway-xref db="Reactome" id="R-SPO-174113" name="SCF-beta-TrCP mediated degradation of Emi1"/>
            <pathway-xref db="Reactome" id="R-MMU-69231" name="Cyclin D associated events in G1"/>
            <pathway-xref db="Reactome" id="R-MMU-5696394" name="DNA Damage Recognition in GG-NER"/>
            <pathway-xref db="Reactome" id="R-CEL-5632684" name="Hedgehog 'on' state"/>
            <pathway-xref db="Reactome" id="R-HSA-1257604" name="PIP3 activates AKT signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-5620916" name="VxPx cargo-targeting to cilium"/>
            <pathway-xref db="Reactome" id="R-DDI-6782210" name="Gap-filling DNA repair synthesis and ligation in TC-NER"/>
            <pathway-xref db="Reactome" id="R-MMU-1257604" name="PIP3 activates AKT signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-5620916" name="VxPx cargo-targeting to cilium"/>
            <pathway-xref db="Reactome" id="R-SCE-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-DDI-187577" name="SCF(Skp2)-mediated degradation of p27/p21"/>
            <pathway-xref db="Reactome" id="R-DME-264876" name="Insulin processing"/>
            <pathway-xref db="Reactome" id="R-CEL-6782135" name="Dual incision in TC-NER"/>
            <pathway-xref db="Reactome" id="R-HSA-2644607" name="Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-4641258" name="Degradation of DVL"/>
            <pathway-xref db="Reactome" id="R-HSA-5676590" name="NIK--&gt;noncanonical NF-kB signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-917937" name="Iron uptake and transport"/>
            <pathway-xref db="Reactome" id="R-HSA-4641258" name="Degradation of DVL"/>
            <pathway-xref db="Reactome" id="R-DDI-174113" name="SCF-beta-TrCP mediated degradation of Emi1"/>
            <pathway-xref db="Reactome" id="R-MMU-9708530" name="Regulation of BACH1 activity"/>
            <pathway-xref db="Reactome" id="R-HSA-5696394" name="DNA Damage Recognition in GG-NER"/>
            <pathway-xref db="Reactome" id="R-DME-209360" name="Ubiquitination and proteolysis of phosphorylated CI"/>
            <pathway-xref db="Reactome" id="R-HSA-6807878" name="COPI-mediated anterograde transport"/>
            <pathway-xref db="Reactome" id="R-HSA-5607761" name="Dectin-1 mediated noncanonical NF-kB signaling"/>
            <pathway-xref db="Reactome" id="R-DRE-264876" name="Insulin processing"/>
            <pathway-xref db="Reactome" id="R-MMU-5696395" name="Formation of Incision Complex in GG-NER"/>
            <pathway-xref db="Reactome" id="R-MMU-6781823" name="Formation of TC-NER Pre-Incision Complex"/>
            <pathway-xref db="Reactome" id="R-DDI-6807878" name="COPI-mediated anterograde transport"/>
            <pathway-xref db="Reactome" id="R-MMU-6807878" name="COPI-mediated anterograde transport"/>
            <pathway-xref db="Reactome" id="R-DME-8951664" name="Neddylation"/>
            <pathway-xref db="Reactome" id="R-CEL-8863795" name="Downregulation of ERBB2 signaling"/>
            <pathway-xref db="Reactome" id="R-DDI-69231" name="Cyclin D associated events in G1"/>
            <pathway-xref db="Reactome" id="R-HSA-8932339" name="ROS sensing by NFE2L2"/>
            <pathway-xref db="Reactome" id="R-DME-8854050" name="FBXL7 down-regulates AURKA during mitotic entry and in early mitosis"/>
            <pathway-xref db="Reactome" id="R-HSA-5610783" name="Degradation of GLI2 by the proteasome"/>
            <pathway-xref db="Reactome" id="R-HSA-6781823" name="Formation of TC-NER Pre-Incision Complex"/>
            <pathway-xref db="Reactome" id="R-HSA-5684264" name="MAP3K8 (TPL2)-dependent MAPK1/3 activation"/>
            <pathway-xref db="Reactome" id="R-CEL-8854050" name="FBXL7 down-regulates AURKA during mitotic entry and in early mitosis"/>
            <pathway-xref db="Reactome" id="R-SPO-6782135" name="Dual incision in TC-NER"/>
            <pathway-xref db="Reactome" id="R-MMU-6811440" name="Retrograde transport at the Trans-Golgi-Network"/>
            <pathway-xref db="Reactome" id="R-DDI-9706019" name="RHOBTB3 ATPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-9708530" name="Regulation of BACH1 activity"/>
            <pathway-xref db="Reactome" id="R-CEL-187577" name="SCF(Skp2)-mediated degradation of p27/p21"/>
            <pathway-xref db="Reactome" id="R-MMU-5607761" name="Dectin-1 mediated noncanonical NF-kB signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-6811438" name="Intra-Golgi traffic"/>
            <pathway-xref db="Reactome" id="R-DME-917937" name="Iron uptake and transport"/>
            <pathway-xref db="Reactome" id="R-MMU-5696400" name="Dual Incision in GG-NER"/>
            <pathway-xref db="Reactome" id="R-DME-195253" name="Degradation of beta-catenin by the destruction complex"/>
            <pathway-xref db="Reactome" id="R-DME-68949" name="Orc1 removal from chromatin"/>
            <pathway-xref db="Reactome" id="R-MMU-4641258" name="Degradation of DVL"/>
            <pathway-xref db="Reactome" id="R-RNO-264876" name="Insulin processing"/>
            <pathway-xref db="Reactome" id="R-DME-5610785" name="GLI3 is processed to GLI3R by the proteasome"/>
            <pathway-xref db="Reactome" id="R-HSA-8951664" name="Neddylation"/>
            <pathway-xref db="Reactome" id="R-CEL-8939902" name="Regulation of RUNX2 expression and activity"/>
            <pathway-xref db="Reactome" id="R-HSA-6782210" name="Gap-filling DNA repair synthesis and ligation in TC-NER"/>
            <pathway-xref db="Reactome" id="R-DME-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-6782210" name="Gap-filling DNA repair synthesis and ligation in TC-NER"/>
            <pathway-xref db="Reactome" id="R-HSA-9706019" name="RHOBTB3 ATPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-195253" name="Degradation of beta-catenin by the destruction complex"/>
            <pathway-xref db="Reactome" id="R-SPO-5696400" name="Dual Incision in GG-NER"/>
            <pathway-xref db="Reactome" id="R-HSA-2871837" name="FCERI mediated NF-kB activation"/>
            <pathway-xref db="Reactome" id="R-HSA-264876" name="Insulin processing"/>
            <pathway-xref db="Reactome" id="R-DDI-4641258" name="Degradation of DVL"/>
            <pathway-xref db="Reactome" id="R-DDI-5696394" name="DNA Damage Recognition in GG-NER"/>
            <pathway-xref db="Reactome" id="R-DME-69231" name="Cyclin D associated events in G1"/>
            <pathway-xref db="Reactome" id="R-HSA-389357" name="CD28 dependent PI3K/Akt signaling"/>
            <pathway-xref db="Reactome" id="R-SPO-8951664" name="Neddylation"/>
            <pathway-xref db="Reactome" id="R-MMU-9013422" name="RHOBTB1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-SPO-68949" name="Orc1 removal from chromatin"/>
            <pathway-xref db="Reactome" id="R-HSA-6811438" name="Intra-Golgi traffic"/>
            <pathway-xref db="Reactome" id="R-MMU-1169091" name="Activation of NF-kappaB in B cells"/>
            <pathway-xref db="Reactome" id="R-HSA-1445148" name="Translocation of SLC2A4 (GLUT4) to the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-DDI-8932339" name="ROS sensing by NFE2L2"/>
            <pathway-xref db="Reactome" id="R-MMU-202424" name="Downstream TCR signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-2894862" name="Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants"/>
            <pathway-xref db="Reactome" id="R-DDI-9013418" name="RHOBTB2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-5610785" name="GLI3 is processed to GLI3R by the proteasome"/>
            <pathway-xref db="Reactome" id="R-DDI-6781823" name="Formation of TC-NER Pre-Incision Complex"/>
            <pathway-xref db="Reactome" id="R-HSA-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-110314" name="Recognition of DNA damage by PCNA-containing replication complex"/>
            <pathway-xref db="Reactome" id="R-MMU-5610785" name="GLI3 is processed to GLI3R by the proteasome"/>
            <pathway-xref db="Reactome" id="R-HSA-2644606" name="Constitutive Signaling by NOTCH1 PEST Domain Mutants"/>
            <pathway-xref db="Reactome" id="R-SPO-110314" name="Recognition of DNA damage by PCNA-containing replication complex"/>
            <pathway-xref db="Reactome" id="R-HSA-9020702" name="Interleukin-1 signaling"/>
            <pathway-xref db="Reactome" id="R-DDI-5632684" name="Hedgehog 'on' state"/>
            <pathway-xref db="Reactome" id="R-RNO-9706019" name="RHOBTB3 ATPase cycle"/>
            <pathway-xref db="Reactome" id="R-DME-9020702" name="Interleukin-1 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9604323" name="Negative regulation of NOTCH4 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-5676590" name="NIK--&gt;noncanonical NF-kB signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-917937" name="Iron uptake and transport"/>
            <pathway-xref db="Reactome" id="R-HSA-180585" name="Vif-mediated degradation of APOBEC3G"/>
            <pathway-xref db="Reactome" id="R-DME-6811438" name="Intra-Golgi traffic"/>
            <pathway-xref db="Reactome" id="R-CEL-6807878" name="COPI-mediated anterograde transport"/>
            <pathway-xref db="Reactome" id="R-MMU-187577" name="SCF(Skp2)-mediated degradation of p27/p21"/>
            <pathway-xref db="Reactome" id="R-CEL-5696395" name="Formation of Incision Complex in GG-NER"/>
            <pathway-xref db="Reactome" id="R-DDI-5658442" name="Regulation of RAS by GAPs"/>
            <pathway-xref db="Reactome" id="R-SPO-8854050" name="FBXL7 down-regulates AURKA during mitotic entry and in early mitosis"/>
          </entry>
          <signature-library-release library="SUPERFAMILY" version="1.75"/>
        </signature>
        <model-ac>0054070</model-ac>
        <locations>
          <superfamilyhmmer3-location hmm-length="347" start="56" end="244">
            <location-fragments>
              <superfamilyhmmer3-location-fragment start="56" end="244" dc-status="CONTINUOUS"/>
            </location-fragments>
          </superfamilyhmmer3-location>
        </locations>
      </superfamilyhmmer3-match>
    </matches>
  </protein>
  <protein>
    <sequence md5="50037ef6d03f038e99b789da412983db">MSWVSSCLGCAKRKEPEVSELDFAHCSLDNVPTDIFAFERTLEKLCLDYNNIRDLPRQLFQCQELKELSVCDNDVHLLPSALASLGHLVRLNVSKNVLTDIPETIKQLKCLEVLDVSVNPLQKVPEGCTQLLNIAELYLNDTFLEFLPANFGRLVKLKILELRENNLTSLPKSLSRLECLERLDVGQNDIVELPDVIGSLVTLKELWVDANRIQVIPAFIGQLKKLHHLEASFNNLENISEEIGQCQDLVHLSLSTNDLKFLPHQIGRCERLITLKVDDNQLESVPQSVGQLCLLEELVVSQNYLENIPSSIGLCRNLHTLNIDDNDVEYLPKELGSCVSLKILSAHGNRLTTLPAELDHIAGLSVINLTANMIQNLPVSFMKLRRITALWLSENQTKPLVQLNQDTDPETGQRVLTNFLLPQMPEADNGTNLDAVSDSGSFHASVWEEERQRKSHVKWAGEADLSVIEEPETDDKGGGHLRREPTPFPKEMRAMAKRVQALRAKESHPNSLHQTHSPSPVCQGERKRERRPSSSSSTDHPSNDRDVPILIREAKVTKPQAANSLPNGYHGETPKRIEKDGKQFQDLERSVHVSNDLNSTASPQIGPHSGPAYKLKISSEGGSRDSGVATPSDGSLTSPDSDQCHRNPSDPLPQRPEGLQQSKQADSNRAVRRPIPPPYHIAAALSKRAGDFQGSSLASLQIQSTNSASDTNSVSESEVSTTASSLQTIVRAPTKMSFDGDNSSANKRLNLSFQETTSKAYQNDAHALQLRKVSEQLLANPRTRQSVTGSSLIHSGSSRPGSFASPSGATPISMLPYSRSNSQMGFGSAPMTSVASNGFAPSLLPRPPNGSGDQSTNGLLTTIEQATISDGEGDSDAASFEQPNYENVSTPKYQIASATRTEITRMNGHVSKGDRLSTSQFVMSPNGHGFNTLLPESNEDNTYIPMMAPKYAANPPQSRGVPLHRGMREGLVPNGHVTNNGPVLPDVFGNSSTSTTPS</sequence>
    <xref id="TCALIF_00696-PA" name="TCALIF_00696-PA protein Name:&quot;Similar to ERBB2IP Protein LAP2 (Homo sapiens)&quot; AED:0.25 eAED:0.25 QI:0|-1|0|1|-1|1|1|0|998"/>
    <matches>
      <hmmer2-match evalue="3.9E-27" score="106.1">
        <signature ac="SM00369" name="LRR_typ_2">
          <entry ac="IPR003591" desc="Leucine-rich repeat, typical subtype" name="Leu-rich_rpt_typical-subtyp" type="REPEAT">
            <pathway-xref db="Reactome" id="R-HSA-5673000" name="RAF activation"/>
            <pathway-xref db="Reactome" id="R-MMU-1474228" name="Degradation of the extracellular matrix"/>
            <pathway-xref db="MetaCyc" id="PWY-7735" name="echinomycin and triostin A biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5461" name="betanidin degradation"/>
            <pathway-xref db="Reactome" id="R-RNO-2022854" name="Keratan sulfate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SPO-5223345" name="Miscellaneous transport and binding events"/>
            <pathway-xref db="Reactome" id="R-MMU-5673000" name="RAF activation"/>
            <pathway-xref db="Reactome" id="R-SCE-5223345" name="Miscellaneous transport and binding events"/>
            <pathway-xref db="Reactome" id="R-HSA-6803207" name="TP53 Regulates Transcription of Caspase Activators and Caspases"/>
            <pathway-xref db="Reactome" id="R-HSA-2565942" name="Regulation of PLK1 Activity at G2/M Transition"/>
            <pathway-xref db="Reactome" id="R-HSA-5673001" name="RAF/MAP kinase cascade"/>
            <pathway-xref db="Reactome" id="R-MMU-6803207" name="TP53 Regulates Transcription of Caspase Activators and Caspases"/>
            <pathway-xref db="Reactome" id="R-MMU-5620912" name="Anchoring of the basal body to the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-MMU-2565942" name="Regulation of PLK1 Activity at G2/M Transition"/>
            <pathway-xref db="Reactome" id="R-HSA-1474228" name="Degradation of the extracellular matrix"/>
            <pathway-xref db="Reactome" id="R-HSA-5620912" name="Anchoring of the basal body to the plasma membrane"/>
            <pathway-xref db="MetaCyc" id="PWY-6998" name="CDP-D-arabitol biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-193634" name="Axonal growth inhibition (RHOA activation)"/>
            <pathway-xref db="Reactome" id="R-HSA-6807004" name="Negative regulation of MET activity"/>
            <pathway-xref db="Reactome" id="R-HSA-9010553" name="Regulation of expression of SLITs and ROBOs"/>
            <pathway-xref db="MetaCyc" id="PWY-7888" name="tRNA-uridine 2-thiolation (cytoplasmic)"/>
            <pathway-xref db="Reactome" id="R-DDI-9013149" name="RAC1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DME-9013406" name="RHOQ GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-8863795" name="Downregulation of ERBB2 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-3560783" name="Defective B4GALT7 causes EDS, progeroid type"/>
            <pathway-xref db="MetaCyc" id="PWY-8143" name="L-ascorbate biosynthesis VII (plants, D-galacturonate pathway)"/>
            <pathway-xref db="Reactome" id="R-HSA-75892" name="Platelet Adhesion to exposed collagen"/>
            <pathway-xref db="Reactome" id="R-CFA-2024101" name="CS/DS degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-8857538" name="PTK6 promotes HIF1A stabilization"/>
            <pathway-xref db="Reactome" id="R-HSA-5602680" name="MyD88 deficiency (TLR5)"/>
            <pathway-xref db="Reactome" id="R-HSA-9620244" name="Long-term potentiation"/>
            <pathway-xref db="Reactome" id="R-RNO-444821" name="Relaxin receptors"/>
            <pathway-xref db="Reactome" id="R-DDI-3295583" name="TRP channels"/>
            <pathway-xref db="MetaCyc" id="PWY-7352" name="daunorubicin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-6794361" name="Neurexins and neuroligins"/>
            <pathway-xref db="Reactome" id="R-DME-214862" name="Activated PLL kinase is autophosphorylated in the TL receptor 'signalling complex'"/>
            <pathway-xref db="Reactome" id="R-HSA-2022857" name="Keratan sulfate degradation"/>
            <pathway-xref db="Reactome" id="R-RNO-9696270" name="RND2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-3656225" name="Defective CHST6 causes MCDC1"/>
            <pathway-xref db="MetaCyc" id="PWY-8179" name="platensimycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DDI-1660517" name="Synthesis of PIPs at the late endosome membrane"/>
            <pathway-xref db="Reactome" id="R-HSA-9665245" name="Resistance of ERBB2 KD mutants to tesevatinib"/>
            <pathway-xref db="Reactome" id="R-SPO-9696270" name="RND2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-9013404" name="RAC2 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-2681" name="trans-zeatin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9617324" name="Negative regulation of NMDA receptor-mediated neuronal transmission"/>
            <pathway-xref db="Reactome" id="R-HSA-8875360" name="InlB-mediated entry of Listeria monocytogenes into host cell"/>
            <pathway-xref db="Reactome" id="R-HSA-9665233" name="Resistance of ERBB2 KD mutants to trastuzumab"/>
            <pathway-xref db="Reactome" id="R-HSA-8863795" name="Downregulation of ERBB2 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-9010553" name="Regulation of expression of SLITs and ROBOs"/>
            <pathway-xref db="MetaCyc" id="PWY-7521" name="3-(4-sulfophenyl)butanoate degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-RNO-438066" name="Unblocking of NMDA receptors, glutamate binding and activation"/>
            <pathway-xref db="Reactome" id="R-MMU-9013408" name="RHOG GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-2024101" name="CS/DS degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-6807004" name="Negative regulation of MET activity"/>
            <pathway-xref db="Reactome" id="R-HSA-8857538" name="PTK6 promotes HIF1A stabilization"/>
            <pathway-xref db="Reactome" id="R-MMU-8985586" name="SLIT2:ROBO1 increases RHOA activity"/>
            <pathway-xref db="Reactome" id="R-HSA-975110" name="TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling"/>
            <pathway-xref db="Reactome" id="R-DRE-2022854" name="Keratan sulfate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-3595172" name="Defective CHST3 causes SEDCJD"/>
            <pathway-xref db="Reactome" id="R-HSA-975155" name="MyD88 dependent cascade initiated on endosome"/>
            <pathway-xref db="Reactome" id="R-HSA-177929" name="Signaling by EGFR"/>
            <pathway-xref db="Reactome" id="R-RNO-8849932" name="Synaptic adhesion-like molecules"/>
            <pathway-xref db="Reactome" id="R-HSA-9665251" name="Resistance of ERBB2 KD mutants to lapatinib"/>
            <pathway-xref db="Reactome" id="R-BTA-1474228" name="Degradation of the extracellular matrix"/>
            <pathway-xref db="MetaCyc" id="PWY-7564" name="bacimethrin and bacimethrin pyrophosphate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-GGA-433822" name="NFkB and MAPK activation mediated by TRAF6"/>
            <pathway-xref db="Reactome" id="R-HSA-5602498" name="MyD88 deficiency (TLR2/4)"/>
            <pathway-xref db="MetaCyc" id="PWY-5835" name="geranyl acetate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-76009" name="Platelet Aggregation (Plug Formation)"/>
            <pathway-xref db="Reactome" id="R-RNO-5686938" name="Regulation of TLR by endogenous ligand"/>
            <pathway-xref db="Reactome" id="R-HSA-1839117" name="Signaling by cytosolic FGFR1 fusion mutants"/>
            <pathway-xref db="Reactome" id="R-MMU-2022857" name="Keratan sulfate degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-2022870" name="Chondroitin sulfate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CFA-3000178" name="ECM proteoglycans"/>
            <pathway-xref db="Reactome" id="R-RNO-5223345" name="Miscellaneous transport and binding events"/>
            <pathway-xref db="Reactome" id="R-SPO-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="MetaCyc" id="PWY-5316" name="nicotine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DRE-429947" name="Deadenylation of mRNA"/>
            <pathway-xref db="Reactome" id="R-HSA-9665686" name="Signaling by ERBB2 TMD/JMD mutants"/>
            <pathway-xref db="Reactome" id="R-DRE-9696270" name="RND2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-5602415" name="UNC93B1 deficiency - HSE"/>
            <pathway-xref db="Reactome" id="R-HSA-9665348" name="Signaling by ERBB2 ECD mutants"/>
            <pathway-xref db="Reactome" id="R-CEL-9010553" name="Regulation of expression of SLITs and ROBOs"/>
            <pathway-xref db="Reactome" id="R-HSA-9013408" name="RHOG GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-9013404" name="RAC2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-9013957" name="TLR3-mediated TICAM1-dependent programmed cell death"/>
            <pathway-xref db="Reactome" id="R-HSA-9673221" name="Defective F9 activation"/>
            <pathway-xref db="Reactome" id="R-MMU-936964" name="Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon"/>
            <pathway-xref db="Reactome" id="R-HSA-9665246" name="Resistance of ERBB2 KD mutants to neratinib"/>
            <pathway-xref db="Reactome" id="R-HSA-193634" name="Axonal growth inhibition (RHOA activation)"/>
            <pathway-xref db="MetaCyc" id="PWY-6749" name="CMP-legionaminate biosynthesis I"/>
            <pathway-xref db="Reactome" id="R-HSA-168179" name="Toll Like Receptor TLR1:TLR2 Cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-381426" name="Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"/>
            <pathway-xref db="Reactome" id="R-BTA-2022923" name="Dermatan sulfate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DDI-5674135" name="MAP2K and MAPK activation"/>
            <pathway-xref db="Reactome" id="R-MMU-5673001" name="RAF/MAP kinase cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-216083" name="Integrin cell surface interactions"/>
            <pathway-xref db="Reactome" id="R-RNO-1971475" name="A tetrasaccharide linker sequence is required for GAG synthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-5673000" name="RAF activation"/>
            <pathway-xref db="Reactome" id="R-DME-209968" name="Thyroxine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7214" name="baicalein degradation (hydrogen peroxide detoxification)"/>
            <pathway-xref db="Reactome" id="R-MMU-9652282" name="Drug-mediated inhibition of ERBB2 signaling"/>
            <pathway-xref db="Reactome" id="R-SSC-168138" name="Toll Like Receptor 9 (TLR9) Cascade"/>
            <pathway-xref db="Reactome" id="R-BTA-2022870" name="Chondroitin sulfate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9665250" name="Resistance of ERBB2 KD mutants to AEE788"/>
            <pathway-xref db="Reactome" id="R-HSA-380259" name="Loss of Nlp from mitotic centrosomes"/>
            <pathway-xref db="Reactome" id="R-HSA-5620916" name="VxPx cargo-targeting to cilium"/>
            <pathway-xref db="Reactome" id="R-CFA-2022870" name="Chondroitin sulfate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-1461957" name="Beta defensins"/>
            <pathway-xref db="Reactome" id="R-HSA-418555" name="G alpha (s) signalling events"/>
            <pathway-xref db="Reactome" id="R-HSA-9652282" name="Drug-mediated inhibition of ERBB2 signaling"/>
            <pathway-xref db="Reactome" id="R-DRE-9013406" name="RHOQ GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-1461957" name="Beta defensins"/>
            <pathway-xref db="Reactome" id="R-HSA-5223345" name="Miscellaneous transport and binding events"/>
            <pathway-xref db="Reactome" id="R-RNO-5682910" name="LGI-ADAM interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-5602410" name="TLR3 deficiency - HSE"/>
            <pathway-xref db="Reactome" id="R-XTR-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-HSA-444821" name="Relaxin receptors"/>
            <pathway-xref db="Reactome" id="R-CFA-109704" name="PI3K Cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-4420332" name="Defective B3GALT6 causes EDSP2 and SEMDJL1"/>
            <pathway-xref db="Reactome" id="R-HSA-168188" name="Toll Like Receptor TLR6:TLR2 Cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-9013148" name="CDC42 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DDI-1632852" name="Macroautophagy"/>
            <pathway-xref db="MetaCyc" id="PWY-6558" name="heparan sulfate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-373752" name="Netrin-1 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-168138" name="Toll Like Receptor 9 (TLR9) Cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-9637628" name="Modulation by Mtb of host immune system"/>
            <pathway-xref db="Reactome" id="R-HSA-168176" name="Toll Like Receptor 5 (TLR5) Cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-166166" name="MyD88-independent TLR4 cascade"/>
            <pathway-xref db="Reactome" id="R-MMU-75892" name="Platelet Adhesion to exposed collagen"/>
            <pathway-xref db="Reactome" id="R-CEL-9013406" name="RHOQ GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-3595177" name="Defective CHSY1 causes TPBS"/>
            <pathway-xref db="Reactome" id="R-HSA-166058" name="MyD88:MAL(TIRAP) cascade initiated on plasma membrane"/>
            <pathway-xref db="MetaCyc" id="PWY-6955" name="lincomycin A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-381426" name="Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"/>
            <pathway-xref db="Reactome" id="R-DDI-8876198" name="RAB GEFs exchange GTP for GDP on RABs"/>
            <pathway-xref db="MetaCyc" id="PWY-6848" name="rutin degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-5682910" name="LGI-ADAM interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-9634285" name="Constitutive Signaling by Overexpressed ERBB2"/>
            <pathway-xref db="Reactome" id="R-HSA-168138" name="Toll Like Receptor 9 (TLR9) Cascade"/>
            <pathway-xref db="MetaCyc" id="PWY-7737" name="thiocoraline biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-9013148" name="CDC42 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-5223345" name="Miscellaneous transport and binding events"/>
            <pathway-xref db="MetaCyc" id="PWY-7713" name="nivalenol biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7529" name="CMP-N-acetyl-7-O-acetylneuraminate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-2243919" name="Crosslinking of collagen fibrils"/>
            <pathway-xref db="Reactome" id="R-HSA-5655302" name="Signaling by FGFR1 in disease"/>
            <pathway-xref db="Reactome" id="R-MMU-380259" name="Loss of Nlp from mitotic centrosomes"/>
            <pathway-xref db="Reactome" id="R-HSA-8985801" name="Regulation of cortical dendrite branching"/>
            <pathway-xref db="Reactome" id="R-HSA-9662360" name="Sensory processing of sound by inner hair cells of the cochlea"/>
            <pathway-xref db="Reactome" id="R-HSA-3595174" name="Defective CHST14 causes EDS, musculocontractural type"/>
            <pathway-xref db="Reactome" id="R-HSA-388844" name="Receptor-type tyrosine-protein phosphatases"/>
            <pathway-xref db="Reactome" id="R-CEL-376176" name="Signaling by ROBO receptors"/>
            <pathway-xref db="Reactome" id="R-HSA-8985586" name="SLIT2:ROBO1 increases RHOA activity"/>
            <pathway-xref db="Reactome" id="R-HSA-4641263" name="Regulation of FZD by ubiquitination"/>
            <pathway-xref db="Reactome" id="R-HSA-3656243" name="Defective ST3GAL3 causes MCT12 and EIEE15"/>
            <pathway-xref db="Reactome" id="R-MMU-5654687" name="Downstream signaling of activated FGFR1"/>
            <pathway-xref db="Reactome" id="R-HSA-9013409" name="RHOJ GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DDI-5675482" name="Regulation of necroptotic cell death"/>
            <pathway-xref db="Reactome" id="R-HSA-1236974" name="ER-Phagosome pathway"/>
            <pathway-xref db="Reactome" id="R-HSA-442982" name="Ras activation upon Ca2+ influx through NMDA receptor"/>
            <pathway-xref db="Reactome" id="R-SPO-199418" name="Negative regulation of the PI3K/AKT network"/>
            <pathway-xref db="MetaCyc" id="PWY-7904" name="tRNA-uridine 2-thiolation (thermophilic bacteria)"/>
            <pathway-xref db="Reactome" id="R-HSA-9679191" name="Potential therapeutics for SARS"/>
            <pathway-xref db="MetaCyc" id="PWY-7511" name="protein ubiquitination"/>
            <pathway-xref db="Reactome" id="R-DME-214869" name="Phosphorylated CACT, DL and DIF homodimers dissociate from the TL receptor 'signalling complex'"/>
            <pathway-xref db="Reactome" id="R-HSA-5682910" name="LGI-ADAM interactions"/>
            <pathway-xref db="Reactome" id="R-DRE-9013148" name="CDC42 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-7884" name="lipoprotein posttranslational modification"/>
            <pathway-xref db="Reactome" id="R-MMU-140837" name="Intrinsic Pathway of Fibrin Clot Formation"/>
            <pathway-xref db="Reactome" id="R-BTA-2022857" name="Keratan sulfate degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-2243919" name="Crosslinking of collagen fibrils"/>
            <pathway-xref db="MetaCyc" id="PWY-8117" name="colibactin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-168164" name="Toll Like Receptor 3 (TLR3) Cascade"/>
            <pathway-xref db="MetaCyc" id="PWY-8247" name="(Kdo)2-lipid A biosynthesis (P. gingivalis)"/>
            <pathway-xref db="Reactome" id="R-HSA-166016" name="Toll Like Receptor 4 (TLR4) Cascade"/>
            <pathway-xref db="Reactome" id="R-CEL-6803207" name="TP53 Regulates Transcription of Caspase Activators and Caspases"/>
            <pathway-xref db="Reactome" id="R-RNO-1474228" name="Degradation of the extracellular matrix"/>
            <pathway-xref db="Reactome" id="R-HSA-428890" name="Role of ABL in ROBO-SLIT signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9665247" name="Resistance of ERBB2 KD mutants to osimertinib"/>
            <pathway-xref db="MetaCyc" id="PWY-6626" name="cytidine-5'-diphosphate-glycerol biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-140534" name="Caspase activation via Death Receptors in the presence of ligand"/>
            <pathway-xref db="Reactome" id="R-HSA-429947" name="Deadenylation of mRNA"/>
            <pathway-xref db="Reactome" id="R-DDI-5673001" name="RAF/MAP kinase cascade"/>
            <pathway-xref db="Reactome" id="R-CEL-209968" name="Thyroxine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8106" name="queuosine biosynthesis III (queuosine salvage)"/>
            <pathway-xref db="Reactome" id="R-HSA-5654687" name="Downstream signaling of activated FGFR1"/>
            <pathway-xref db="Reactome" id="R-MMU-4641263" name="Regulation of FZD by ubiquitination"/>
            <pathway-xref db="Reactome" id="R-HSA-438066" name="Unblocking of NMDA receptors, glutamate binding and activation"/>
            <pathway-xref db="MetaCyc" id="PWY-7660" name="tryptoquialanine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DDI-1169092" name="Activation of RAS in B cells"/>
            <pathway-xref db="Reactome" id="R-HSA-936964" name="Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon"/>
            <pathway-xref db="MetaCyc" id="PWY-5381" name="NAD salvage (plants)"/>
            <pathway-xref db="Reactome" id="R-RNO-163125" name="Post-translational modification: synthesis of GPI-anchored proteins"/>
            <pathway-xref db="Reactome" id="R-MMU-380270" name="Recruitment of mitotic centrosome proteins and complexes"/>
            <pathway-xref db="Reactome" id="R-HSA-428543" name="Inactivation of CDC42 and RAC1"/>
            <pathway-xref db="Reactome" id="R-MMU-376176" name="Signaling by ROBO receptors"/>
            <pathway-xref db="Reactome" id="R-MMU-3000178" name="ECM proteoglycans"/>
            <pathway-xref db="Reactome" id="R-HSA-6794361" name="Neurexins and neuroligins"/>
            <pathway-xref db="Reactome" id="R-HSA-9013973" name="TICAM1-dependent activation of IRF3/IRF7"/>
            <pathway-xref db="Reactome" id="R-HSA-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-BTA-2024101" name="CS/DS degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7002" name="4-hydroxyacetophenone degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-1227986" name="Signaling by ERBB2"/>
            <pathway-xref db="Reactome" id="R-MMU-9013406" name="RHOQ GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-166016" name="Toll Like Receptor 4 (TLR4) Cascade"/>
            <pathway-xref db="Reactome" id="R-RNO-5654687" name="Downstream signaling of activated FGFR1"/>
            <pathway-xref db="Reactome" id="R-HSA-9013406" name="RHOQ GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-7419" name="FR-900098 and FR-33289 antibiotics biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-4608870" name="Asymmetric localization of PCP proteins"/>
            <pathway-xref db="MetaCyc" id="PWY-6824" name="justicidin B biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-9013149" name="RAC1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-140534" name="Caspase activation via Death Receptors in the presence of ligand"/>
            <pathway-xref db="Reactome" id="R-GGA-517856" name="TLR2 subfamily cascade"/>
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            <pathway-xref db="Reactome" id="R-HSA-9662360" name="Sensory processing of sound by inner hair cells of the cochlea"/>
            <pathway-xref db="Reactome" id="R-HSA-388844" name="Receptor-type tyrosine-protein phosphatases"/>
            <pathway-xref db="Reactome" id="R-CEL-376176" name="Signaling by ROBO receptors"/>
            <pathway-xref db="MetaCyc" id="PWY-7543" name="5-N-acetylardeemin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7109" name="megalomicin A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-4641263" name="Regulation of FZD by ubiquitination"/>
            <pathway-xref db="MetaCyc" id="PWY-5797" name="indole-3-acetate inactivation VI"/>
            <pathway-xref db="MetaCyc" id="PWY-5784" name="indole-3-acetate inactivation VIII"/>
            <pathway-xref db="MetaCyc" id="PWY-5679" name="clavulanate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9013409" name="RHOJ GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-442982" name="Ras activation upon Ca2+ influx through NMDA receptor"/>
            <pathway-xref db="Reactome" id="R-HSA-9679191" name="Potential therapeutics for SARS"/>
            <pathway-xref db="MetaCyc" id="PWY-7987" name="vanchrobactin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7511" name="protein ubiquitination"/>
            <pathway-xref db="Reactome" id="R-HSA-5682910" name="LGI-ADAM interactions"/>
            <pathway-xref db="MetaCyc" id="PWY-8075" name="(Kdo)2-lipid A biosynthesis (P. putida)"/>
            <pathway-xref db="MetaCyc" id="PWY-7821" name="tunicamycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-BTA-2022857" name="Keratan sulfate degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-450520" name="HuR (ELAVL1) binds and stabilizes mRNA"/>
            <pathway-xref db="Reactome" id="R-HSA-6803205" name="TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain"/>
            <pathway-xref db="MetaCyc" id="PWY-8247" name="(Kdo)2-lipid A biosynthesis (P. gingivalis)"/>
            <pathway-xref db="Reactome" id="R-DME-159230" name="Transport of the SLBP Dependant Mature mRNA"/>
            <pathway-xref db="MetaCyc" id="PWY-1961" name="indole-3-acetate inactivation I"/>
            <pathway-xref db="Reactome" id="R-HSA-428890" name="Role of ABL in ROBO-SLIT signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9665247" name="Resistance of ERBB2 KD mutants to osimertinib"/>
            <pathway-xref db="MetaCyc" id="PWY-7981" name="alpha-dystroglycan glycosylation"/>
            <pathway-xref db="Reactome" id="R-MMU-844455" name="The NLRP1 inflammasome"/>
            <pathway-xref db="Reactome" id="R-RNO-177504" name="Retrograde neurotrophin signalling"/>
            <pathway-xref db="Reactome" id="R-HSA-429947" name="Deadenylation of mRNA"/>
            <pathway-xref db="MetaCyc" id="PWY-7547" name="prodigiosin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-2881" name="cytokinins 7-N-glucoside biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8106" name="queuosine biosynthesis III (queuosine salvage)"/>
            <pathway-xref db="Reactome" id="R-MMU-4641263" name="Regulation of FZD by ubiquitination"/>
            <pathway-xref db="MetaCyc" id="PWY-7660" name="tryptoquialanine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-9032759" name="NTRK2 activates RAC1"/>
            <pathway-xref db="Reactome" id="R-RNO-936440" name="Negative regulators of DDX58/IFIH1 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-936964" name="Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon"/>
            <pathway-xref db="Reactome" id="R-DDI-1169092" name="Activation of RAS in B cells"/>
            <pathway-xref db="MetaCyc" id="PWY-5756" name="saponin biosynthesis II"/>
            <pathway-xref db="Reactome" id="R-RNO-163125" name="Post-translational modification: synthesis of GPI-anchored proteins"/>
            <pathway-xref db="MetaCyc" id="PWY-5339" name="chalcone 2'-O-glucoside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-376176" name="Signaling by ROBO receptors"/>
            <pathway-xref db="Reactome" id="R-MMU-3000178" name="ECM proteoglycans"/>
            <pathway-xref db="Reactome" id="R-CEL-72163" name="mRNA Splicing - Major Pathway"/>
            <pathway-xref db="Reactome" id="R-RNO-9034793" name="Activated NTRK3 signals through PLCG1"/>
            <pathway-xref db="MetaCyc" id="PWY-7265" name="lampranthin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CFA-8951664" name="Neddylation"/>
            <pathway-xref db="Reactome" id="R-XTR-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-BTA-2024101" name="CS/DS degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-198203" name="PI3K/AKT activation"/>
            <pathway-xref db="MetaCyc" id="PWY-7018" name="paromomycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9013406" name="RHOQ GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-7419" name="FR-900098 and FR-33289 antibiotics biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7818" name="type IV lipoteichoic acid biosynthesis (S. pneumoniae)"/>
            <pathway-xref db="Reactome" id="R-RNO-9013149" name="RAC1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-140534" name="Caspase activation via Death Receptors in the presence of ligand"/>
            <pathway-xref db="MetaCyc" id="PWY-6385" name="peptidoglycan biosynthesis III (mycobacteria)"/>
            <pathway-xref db="Reactome" id="R-GGA-517856" name="TLR2 subfamily cascade"/>
            <pathway-xref db="MetaCyc" id="PWY-7624" name="nystatin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6397" name="mycolyl-arabinogalactan-peptidoglycan complex biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-446388" name="Regulation of cytoskeletal remodeling and cell spreading by IPP complex components"/>
            <pathway-xref db="MetaCyc" id="PWY-7601" name="arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)"/>
            <pathway-xref db="MetaCyc" id="PWY-7950" name="diadinoxanthin and fucoxanthin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8249" name="xanthommatin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6297" name="tuberonate glucoside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-9707616" name="Heme signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-2467813" name="Separation of Sister Chromatids"/>
            <pathway-xref db="Reactome" id="R-HSA-450520" name="HuR (ELAVL1) binds and stabilizes mRNA"/>
            <pathway-xref db="MetaCyc" id="PWY-7930" name="pyoluteorin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DRE-8854050" name="FBXL7 down-regulates AURKA during mitotic entry and in early mitosis"/>
            <pathway-xref db="Reactome" id="R-RNO-8951664" name="Neddylation"/>
            <pathway-xref db="Reactome" id="R-DME-214842" name="DL and DIF homodimers bind to TUB and phosphorylated PLL in the TL receptor 'signalling complex'"/>
            <pathway-xref db="Reactome" id="R-HSA-2467813" name="Separation of Sister Chromatids"/>
            <pathway-xref db="MetaCyc" id="PWY-6842" name="glutathione-mediated detoxification II"/>
            <pathway-xref db="Reactome" id="R-MMU-937041" name="IKK complex recruitment mediated by RIP1"/>
            <pathway-xref db="MetaCyc" id="PWY-8212" name="Escherichia coli serotype O:8 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-2022854" name="Keratan sulfate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5161" name="6'-deoxychalcone metabolism"/>
            <pathway-xref db="MetaCyc" id="PWY-7569" name="arginomycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-2022854" name="Keratan sulfate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-4641263" name="Regulation of FZD by ubiquitination"/>
            <pathway-xref db="Reactome" id="R-HSA-8936459" name="RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"/>
            <pathway-xref db="Reactome" id="R-RNO-9032759" name="NTRK2 activates RAC1"/>
            <pathway-xref db="MetaCyc" id="PWY-7982" name="pinoresinol degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7983" name="pseudomonine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DDI-202670" name="ERKs are inactivated"/>
            <pathway-xref db="Reactome" id="R-MMU-168638" name="NOD1/2 Signaling Pathway"/>
            <pathway-xref db="Reactome" id="R-MMU-388844" name="Receptor-type tyrosine-protein phosphatases"/>
            <pathway-xref db="MetaCyc" id="PWY-5400" name="amaranthin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-3108232" name="SUMO E3 ligases SUMOylate target proteins"/>
            <pathway-xref db="Reactome" id="R-DDI-5213460" name="RIPK1-mediated regulated necrosis"/>
            <pathway-xref db="Reactome" id="R-MMU-8854518" name="AURKA Activation by TPX2"/>
            <pathway-xref db="MetaCyc" id="PWY-8244" name="Escherichia coli serotype O:177 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9014325" name="TICAM1,TRAF6-dependent induction of TAK1 complex"/>
            <pathway-xref db="Reactome" id="R-MMU-977606" name="Regulation of Complement cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-168181" name="Toll Like Receptor 7/8 (TLR7/8) Cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-9026527" name="Activated NTRK2 signals through PLCG1"/>
            <pathway-xref db="Reactome" id="R-HSA-177504" name="Retrograde neurotrophin signalling"/>
            <pathway-xref db="Reactome" id="R-MMU-170968" name="Frs2-mediated activation"/>
            <pathway-xref db="MetaCyc" id="PWY-8232" name="Shigella boydii serotype 6 O antigen biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7817" name="type I lipoteichoic acid biosynthesis (S. aureus)"/>
            <pathway-xref db="MetaCyc" id="PWY-6322" name="phosphinothricin tripeptide biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-450520" name="HuR (ELAVL1) binds and stabilizes mRNA"/>
            <pathway-xref db="MetaCyc" id="PWY-5710" name="capsaicin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-5793" name="maysin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DRE-9696264" name="RND3 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-380320" name="Recruitment of NuMA to mitotic centrosomes"/>
            <pathway-xref db="MetaCyc" id="PWY-5437" name="L-threonine degradation I"/>
            <pathway-xref db="MetaCyc" id="PWY-7474" name="avenacin A-2 biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9034015" name="Signaling by NTRK3 (TRKC)"/>
            <pathway-xref db="Reactome" id="R-MMU-428890" name="Role of ABL in ROBO-SLIT signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-68877" name="Mitotic Prometaphase"/>
            <pathway-xref db="MetaCyc" id="PWY-6401" name="hispidol and hispidol 4'-O-beta-D-glucoside biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5379" name="B series fagopyritols biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SPO-8949613" name="Cristae formation"/>
            <pathway-xref db="Reactome" id="R-MMU-983231" name="Factors involved in megakaryocyte development and platelet production"/>
            <pathway-xref db="Reactome" id="R-HSA-165054" name="Rev-mediated nuclear export of HIV RNA"/>
            <pathway-xref db="Reactome" id="R-MMU-2562578" name="TRIF-mediated programmed cell death"/>
            <pathway-xref db="MetaCyc" id="PWY-7037" name="protein O-glycosylation (Neisseria)"/>
            <pathway-xref db="Reactome" id="R-HSA-2562578" name="TRIF-mediated programmed cell death"/>
            <pathway-xref db="Reactome" id="R-CFA-1474228" name="Degradation of the extracellular matrix"/>
            <pathway-xref db="Reactome" id="R-DDI-5621575" name="CD209 (DC-SIGN) signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-844455" name="The NLRP1 inflammasome"/>
            <pathway-xref db="Reactome" id="R-CEL-438066" name="Unblocking of NMDA receptors, glutamate binding and activation"/>
            <pathway-xref db="Reactome" id="R-DME-376176" name="Signaling by ROBO receptors"/>
            <pathway-xref db="Reactome" id="R-HSA-5686938" name="Regulation of TLR by endogenous ligand"/>
            <pathway-xref db="Reactome" id="R-MMU-159227" name="Transport of the SLBP independent Mature mRNA"/>
            <pathway-xref db="Reactome" id="R-MMU-168181" name="Toll Like Receptor 7/8 (TLR7/8) Cascade"/>
            <pathway-xref db="MetaCyc" id="PWY-7697" name="geranyl beta-primeveroside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-159236" name="Transport of Mature mRNA derived from an Intron-Containing Transcript"/>
            <pathway-xref db="MetaCyc" id="PWY-7172" name="flavonol acylglucoside biosynthesis III - quercetin derivatives"/>
            <pathway-xref db="MetaCyc" id="PWY-6314" name="plumbagin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-376176" name="Signaling by ROBO receptors"/>
            <pathway-xref db="Reactome" id="R-GGA-451514" name="MyD88:TIRAP-dependent cascade initiated on plasma membrane"/>
            <pathway-xref db="Reactome" id="R-RNO-198203" name="PI3K/AKT activation"/>
            <pathway-xref db="MetaCyc" id="PWY-6032" name="digitoxigenin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9665244" name="Resistance of ERBB2 KD mutants to sapitinib"/>
            <pathway-xref db="Reactome" id="R-DRE-8951664" name="Neddylation"/>
            <pathway-xref db="MetaCyc" id="PWY-7473" name="avenacin A-1 biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-6803207" name="TP53 Regulates Transcription of Caspase Activators and Caspases"/>
            <pathway-xref db="Reactome" id="R-GGA-388844" name="Receptor-type tyrosine-protein phosphatases"/>
            <pathway-xref db="Reactome" id="R-HSA-8854518" name="AURKA Activation by TPX2"/>
            <pathway-xref db="MetaCyc" id="PWY-7716" name="penicillin G and penicillin V biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-3108232" name="SUMO E3 ligases SUMOylate target proteins"/>
            <pathway-xref db="Reactome" id="R-DDI-1483248" name="Synthesis of PIPs at the ER membrane"/>
            <pathway-xref db="MetaCyc" id="PWY-7192" name="quercetin diglycoside biosynthesis (pollen-specific)"/>
            <pathway-xref db="Reactome" id="R-HSA-8876493" name="InlA-mediated entry of Listeria monocytogenes into host cells"/>
            <pathway-xref db="Reactome" id="R-DRE-6804115" name="TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"/>
            <pathway-xref db="MetaCyc" id="PWY-7885" name="phosphatidylinositol mannoside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9660537" name="Signaling by MRAS-complex mutants"/>
            <pathway-xref db="MetaCyc" id="PWY-6190" name="2,4-dichlorotoluene degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-9707616" name="Heme signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-7475" name="des-methyl avenacin A-1 biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6320" name="phaselate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6623" name="salicylate glucosides biosynthesis II"/>
            <pathway-xref db="MetaCyc" id="PWY-6407" name="yersiniabactin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-5686938" name="Regulation of TLR by endogenous ligand"/>
            <pathway-xref db="Reactome" id="R-GGA-9026527" name="Activated NTRK2 signals through PLCG1"/>
            <pathway-xref db="MetaCyc" id="PWY-2021" name="indole-3-acetate inactivation IV"/>
            <pathway-xref db="Reactome" id="R-HSA-140837" name="Intrinsic Pathway of Fibrin Clot Formation"/>
            <pathway-xref db="MetaCyc" id="PWY-5975" name="furaneol and mesifurane biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-DME-214863" name="Adaptor protein complex binds to TL receptor at the plasma membrane"/>
            <pathway-xref db="MetaCyc" id="PWY-8122" name="mycofactocin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5286" name="anthocyanidin sophoroside metabolism"/>
            <pathway-xref db="Reactome" id="R-MMU-5663220" name="RHO GTPases Activate Formins"/>
            <pathway-xref db="MetaCyc" id="PWY-7415" name="tylosin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6015" name="vitexin and derivatives biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-5602571" name="TRAF3 deficiency - HSE"/>
            <pathway-xref db="MetaCyc" id="PWY-7254" name="TCA cycle VII (acetate-producers)"/>
            <pathway-xref db="Reactome" id="R-RNO-9034013" name="NTF3 activates NTRK3 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-6946" name="cholesterol degradation to androstenedione II (cholesterol dehydrogenase)"/>
            <pathway-xref db="Reactome" id="R-RNO-844456" name="The NLRP3 inflammasome"/>
            <pathway-xref db="MetaCyc" id="PWY-6624" name="salicylate glucosides biosynthesis III"/>
            <pathway-xref db="Reactome" id="R-MMU-9013106" name="RHOC GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-5663220" name="RHO GTPases Activate Formins"/>
            <pathway-xref db="Reactome" id="R-MMU-216083" name="Integrin cell surface interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-2022923" name="Dermatan sulfate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-8941413" name="Events associated with phagocytolytic activity of PMN cells"/>
            <pathway-xref db="Reactome" id="R-DME-159236" name="Transport of Mature mRNA derived from an Intron-Containing Transcript"/>
            <pathway-xref db="Reactome" id="R-DDI-193648" name="NRAGE signals death through JNK"/>
            <pathway-xref db="Reactome" id="R-MMU-76009" name="Platelet Aggregation (Plug Formation)"/>
            <pathway-xref db="Reactome" id="R-GGA-2022854" name="Keratan sulfate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-3656244" name="Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)"/>
            <pathway-xref db="Reactome" id="R-BTA-1971475" name="A tetrasaccharide linker sequence is required for GAG synthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-9708530" name="Regulation of BACH1 activity"/>
            <pathway-xref db="Reactome" id="R-HSA-9024909" name="BDNF activates NTRK2 (TRKB) signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-5473" name="hydroxycinnamic acid serotonin amides biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-109704" name="PI3K Cascade"/>
            <pathway-xref db="Reactome" id="R-MMU-438066" name="Unblocking of NMDA receptors, glutamate binding and activation"/>
            <pathway-xref db="Reactome" id="R-CFA-1971475" name="A tetrasaccharide linker sequence is required for GAG synthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-177929" name="Signaling by EGFR"/>
            <pathway-xref db="MetaCyc" id="PWY-1921" name="indole-3-acetate activation II"/>
            <pathway-xref db="Reactome" id="R-HSA-3134975" name="Regulation of innate immune responses to cytosolic DNA"/>
            <pathway-xref db="Reactome" id="R-HSA-159231" name="Transport of Mature mRNA Derived from an Intronless Transcript"/>
            <pathway-xref db="MetaCyc" id="PWY-7186" name="superpathway of scopolin and esculin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DRE-5673000" name="RAF activation"/>
            <pathway-xref db="MetaCyc" id="PWY-8082" name="glycine lipid biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-975138" name="TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation"/>
            <pathway-xref db="MetaCyc" id="PWY-8289" name="dZTP biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7565" name="aspyridone A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-3270619" name="IRF3-mediated induction of type I IFN"/>
            <pathway-xref db="Reactome" id="R-DDI-354192" name="Integrin signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-975871" name="MyD88 cascade initiated on plasma membrane"/>
            <pathway-xref db="Reactome" id="R-MMU-3134975" name="Regulation of innate immune responses to cytosolic DNA"/>
            <pathway-xref db="MetaCyc" id="PWY-7769" name="phosalacine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-428890" name="Role of ABL in ROBO-SLIT signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-6378" name="putrebactin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8220" name="Escherichia coli serotype O:117 O antigen biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7252" name="luteolinidin 5-O-glucoside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DRE-8849932" name="Synaptic adhesion-like molecules"/>
            <pathway-xref db="Reactome" id="R-RNO-9603381" name="Activated NTRK3 signals through PI3K"/>
            <pathway-xref db="Reactome" id="R-MMU-166020" name="Transfer of LPS from LBP carrier to CD14"/>
            <pathway-xref db="Reactome" id="R-HSA-199418" name="Negative regulation of the PI3K/AKT network"/>
            <pathway-xref db="MetaCyc" id="PWY-7058" name="esculetin modification"/>
            <pathway-xref db="Reactome" id="R-DRE-380270" name="Recruitment of mitotic centrosome proteins and complexes"/>
            <pathway-xref db="Reactome" id="R-HSA-9708530" name="Regulation of BACH1 activity"/>
            <pathway-xref db="MetaCyc" id="PWY-7445" name="luteolin triglucuronide degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-8955332" name="Carboxyterminal post-translational modifications of tubulin"/>
            <pathway-xref db="Reactome" id="R-HSA-975163" name="IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation"/>
            <pathway-xref db="Reactome" id="R-HSA-163125" name="Post-translational modification: synthesis of GPI-anchored proteins"/>
            <pathway-xref db="Reactome" id="R-MMU-444821" name="Relaxin receptors"/>
            <pathway-xref db="MetaCyc" id="PWY-5903" name="bacillibactin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-9696264" name="RND3 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-7738" name="polyacyltrehalose biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-RNO-6804115" name="TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"/>
            <pathway-xref db="MetaCyc" id="PWY-7689" name="8-O-methylfusarubin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CFA-168138" name="Toll Like Receptor 9 (TLR9) Cascade"/>
            <pathway-xref db="Reactome" id="R-RNO-429947" name="Deadenylation of mRNA"/>
            <pathway-xref db="Reactome" id="R-DDI-392517" name="Rap1 signalling"/>
            <pathway-xref db="Reactome" id="R-HSA-2022870" name="Chondroitin sulfate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-438066" name="Unblocking of NMDA receptors, glutamate binding and activation"/>
            <pathway-xref db="MetaCyc" id="PWY-8058" name="2-deoxy-D-ribose degradation II"/>
            <pathway-xref db="MetaCyc" id="PWY-7577" name="ferrichrome biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5338" name="galactosylcyclitol biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6279" name="myxol-2' fucoside biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6383" name="mono-trans, poly-cis decaprenyl phosphate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6051" name="2,4,6-trinitrotoluene degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7940" name="lauryl-hydroxychlorobactene glucoside biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6239" name="luteolin glycosides biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9026519" name="Activated NTRK2 signals through RAS"/>
            <pathway-xref db="Reactome" id="R-MMU-9026527" name="Activated NTRK2 signals through PLCG1"/>
            <pathway-xref db="Reactome" id="R-DME-209442" name="Formation of the trans-membrane 'signalling complex'"/>
            <pathway-xref db="Reactome" id="R-MMU-380284" name="Loss of proteins required for interphase microtubule organization from the centrosome"/>
            <pathway-xref db="Reactome" id="R-RNO-9013423" name="RAC3 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-5672" name="ginsenosides biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7139" name="sesaminol glucoside biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6039" name="chlorogenic acid biosynthesis I"/>
            <pathway-xref db="Reactome" id="R-HSA-170984" name="ARMS-mediated activation"/>
            <pathway-xref db="Reactome" id="R-HSA-1679131" name="Trafficking and processing of endosomal TLR"/>
            <pathway-xref db="MetaCyc" id="PWY-561" name="superpathway of glyoxylate cycle and fatty acid degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-6945" name="cholesterol degradation to androstenedione I (cholesterol oxidase)"/>
            <pathway-xref db="MetaCyc" id="PWY-7464" name="cyanidin 3,7-diglucoside polyacylation biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-8941413" name="Events associated with phagocytolytic activity of PMN cells"/>
            <pathway-xref db="MetaCyc" id="PWY-7726" name="(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)"/>
            <pathway-xref db="MetaCyc" id="PWY-6763" name="salicortin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-159227" name="Transport of the SLBP independent Mature mRNA"/>
            <pathway-xref db="Reactome" id="R-SCE-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-MMU-430116" name="GP1b-IX-V activation signalling"/>
            <pathway-xref db="MetaCyc" id="PWY-6546" name="brassinosteroids inactivation"/>
            <pathway-xref db="Reactome" id="R-DME-388844" name="Receptor-type tyrosine-protein phosphatases"/>
            <pathway-xref db="MetaCyc" id="PWY-5936" name="xyloglucan biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-9028731" name="Activated NTRK2 signals through FRS2 and FRS3"/>
            <pathway-xref db="MetaCyc" id="PWY-8210" name="pyrrolomycin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6346" name="staurosporine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-BTA-450520" name="HuR (ELAVL1) binds and stabilizes mRNA"/>
            <pathway-xref db="Reactome" id="R-HSA-9028731" name="Activated NTRK2 signals through FRS2 and FRS3"/>
            <pathway-xref db="MetaCyc" id="PWY-5292" name="vindoline, vindorosine and vinblastine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7280" name="ternatin C3 biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-5673000" name="RAF activation"/>
            <pathway-xref db="Reactome" id="R-MMU-3270619" name="IRF3-mediated induction of type I IFN"/>
            <pathway-xref db="Reactome" id="R-HSA-9665249" name="Resistance of ERBB2 KD mutants to afatinib"/>
            <pathway-xref db="Reactome" id="R-MMU-937072" name="TRAF6-mediated induction of TAK1 complex within TLR4 complex"/>
            <pathway-xref db="Reactome" id="R-MMU-1679131" name="Trafficking and processing of endosomal TLR"/>
            <pathway-xref db="MetaCyc" id="PWY-6972" name="oleandomycin activation/inactivation"/>
            <pathway-xref db="MetaCyc" id="PWY-7367" name="phosphatidylcholine resynthesis via glycerophosphocholine"/>
            <pathway-xref db="Reactome" id="R-MMU-2022923" name="Dermatan sulfate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6027" name="capsiconiate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8039" name="mitomycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-GGA-2022857" name="Keratan sulfate degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-9665737" name="Drug resistance in ERBB2 TMD/JMD mutants"/>
            <pathway-xref db="MetaCyc" id="PWY-7907" name="(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7555" name="alpha-cyclopiazonate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-3000178" name="ECM proteoglycans"/>
            <pathway-xref db="MetaCyc" id="PWY-7954" name="tabtoxinine-beta-lactam biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9013106" name="RHOC GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-CEL-6807004" name="Negative regulation of MET activity"/>
            <pathway-xref db="MetaCyc" id="PWY-8221" name="Escherichia coli serotype O:111/Salmonella enterica serotype O:35 O antigen biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7140" name="myricetin gentiobioside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-5673000" name="RAF activation"/>
            <pathway-xref db="MetaCyc" id="PWY-7735" name="echinomycin and triostin A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-2022854" name="Keratan sulfate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SPO-5223345" name="Miscellaneous transport and binding events"/>
            <pathway-xref db="Reactome" id="R-MMU-5673000" name="RAF activation"/>
            <pathway-xref db="MetaCyc" id="PWY-7621" name="autoinducer CAI-1 biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-445989" name="TAK1 activates NFkB by phosphorylation and activation of IKKs complex"/>
            <pathway-xref db="MetaCyc" id="PWY-5994" name="palmitate biosynthesis I (type I fatty acid synthase)"/>
            <pathway-xref db="Reactome" id="R-CEL-159236" name="Transport of Mature mRNA derived from an Intron-Containing Transcript"/>
            <pathway-xref db="Reactome" id="R-RNO-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-450321" name="JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1"/>
            <pathway-xref db="Reactome" id="R-HSA-9010553" name="Regulation of expression of SLITs and ROBOs"/>
            <pathway-xref db="MetaCyc" id="PWY-8047" name="bryostatin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7711" name="calonectrin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-3560783" name="Defective B4GALT7 causes EDS, progeroid type"/>
            <pathway-xref db="MetaCyc" id="PWY-6948" name="sitosterol degradation to androstenedione"/>
            <pathway-xref db="MetaCyc" id="PWY-7100" name="spinosyn A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CFA-2024101" name="CS/DS degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-5602680" name="MyD88 deficiency (TLR5)"/>
            <pathway-xref db="Reactome" id="R-DRE-380284" name="Loss of proteins required for interphase microtubule organization from the centrosome"/>
            <pathway-xref db="Reactome" id="R-DDI-3295583" name="TRP channels"/>
            <pathway-xref db="MetaCyc" id="PWY-7352" name="daunorubicin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-214862" name="Activated PLL kinase is autophosphorylated in the TL receptor 'signalling complex'"/>
            <pathway-xref db="Reactome" id="R-MMU-9034793" name="Activated NTRK3 signals through PLCG1"/>
            <pathway-xref db="Reactome" id="R-HSA-2022857" name="Keratan sulfate degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-936440" name="Negative regulators of DDX58/IFIH1 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-9696270" name="RND2 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-8230" name="Salmonella enterica serotype O:13 O antigen biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6525" name="stellariose and mediose biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9665245" name="Resistance of ERBB2 KD mutants to tesevatinib"/>
            <pathway-xref db="MetaCyc" id="PWY-2681" name="trans-zeatin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9013404" name="RAC2 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-8211" name="Escherichia coli serotype O:7 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-159230" name="Transport of the SLBP Dependant Mature mRNA"/>
            <pathway-xref db="MetaCyc" id="PWY-7449" name="acylated cyanidin galactoside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DRE-450520" name="HuR (ELAVL1) binds and stabilizes mRNA"/>
            <pathway-xref db="MetaCyc" id="PWY-8241" name="Escherichia coli serotype O:71/Salmonella enterica serotype O:28ac O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9665233" name="Resistance of ERBB2 KD mutants to trastuzumab"/>
            <pathway-xref db="MetaCyc" id="PWY-822" name="fructan biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-9010553" name="Regulation of expression of SLITs and ROBOs"/>
            <pathway-xref db="Reactome" id="R-MMU-159230" name="Transport of the SLBP Dependant Mature mRNA"/>
            <pathway-xref db="Reactome" id="R-HSA-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="MetaCyc" id="PWY-8251" name="Escherichia coli serotype O:2 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-9026527" name="Activated NTRK2 signals through PLCG1"/>
            <pathway-xref db="Reactome" id="R-HSA-936440" name="Negative regulators of DDX58/IFIH1 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-2024101" name="CS/DS degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-8116" name="ochratoxin A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-8985586" name="SLIT2:ROBO1 increases RHOA activity"/>
            <pathway-xref db="Reactome" id="R-HSA-975110" name="TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling"/>
            <pathway-xref db="Reactome" id="R-DRE-2022854" name="Keratan sulfate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-975155" name="MyD88 dependent cascade initiated on endosome"/>
            <pathway-xref db="MetaCyc" id="PWY-8133" name="succinoglycan biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-177929" name="Signaling by EGFR"/>
            <pathway-xref db="MetaCyc" id="PWY-8081" name="leucine-derived hydroxynitrile glucoside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-GGA-9028731" name="Activated NTRK2 signals through FRS2 and FRS3"/>
            <pathway-xref db="Reactome" id="R-BTA-1474228" name="Degradation of the extracellular matrix"/>
            <pathway-xref db="MetaCyc" id="PWY-7564" name="bacimethrin and bacimethrin pyrophosphate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8040" name="ansatrienin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-GGA-433822" name="NFkB and MAPK activation mediated by TRAF6"/>
            <pathway-xref db="MetaCyc" id="PWY-8272" name="Escherichia coli serotype O:49 O antigen biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7137" name="quercetin gentiotetraside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-5602498" name="MyD88 deficiency (TLR2/4)"/>
            <pathway-xref db="Reactome" id="R-MMU-9013424" name="RHOV GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-6969" name="TCA cycle V (2-oxoglutarate synthase)"/>
            <pathway-xref db="Reactome" id="R-RNO-5686938" name="Regulation of TLR by endogenous ligand"/>
            <pathway-xref db="Reactome" id="R-MMU-2022857" name="Keratan sulfate degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-8252" name="Escherichia coli serotype O:50 O antigen biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8236" name="Salmonella enterica serotype O:39 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SPO-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="MetaCyc" id="PWY-5316" name="nicotine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DRE-429947" name="Deadenylation of mRNA"/>
            <pathway-xref db="Reactome" id="R-HSA-9665686" name="Signaling by ERBB2 TMD/JMD mutants"/>
            <pathway-xref db="Reactome" id="R-DRE-9696270" name="RND2 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-6373" name="acrylate degradation I"/>
            <pathway-xref db="Reactome" id="R-MMU-2500257" name="Resolution of Sister Chromatid Cohesion"/>
            <pathway-xref db="Reactome" id="R-HSA-5602415" name="UNC93B1 deficiency - HSE"/>
            <pathway-xref db="Reactome" id="R-HSA-2500257" name="Resolution of Sister Chromatid Cohesion"/>
            <pathway-xref db="MetaCyc" id="PWY-1901" name="aurone biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9032845" name="Activated NTRK2 signals through CDK5"/>
            <pathway-xref db="Reactome" id="R-HSA-9034793" name="Activated NTRK3 signals through PLCG1"/>
            <pathway-xref db="Reactome" id="R-CEL-9615933" name="Postmitotic nuclear pore complex (NPC) reformation"/>
            <pathway-xref db="Reactome" id="R-MMU-9013404" name="RAC2 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-7143" name="kaempferol gentiobioside biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5129" name="sphingolipid biosynthesis (plants)"/>
            <pathway-xref db="Reactome" id="R-HSA-9013957" name="TLR3-mediated TICAM1-dependent programmed cell death"/>
            <pathway-xref db="Reactome" id="R-HSA-9673221" name="Defective F9 activation"/>
            <pathway-xref db="MetaCyc" id="PWY-7384" name="anaerobic energy metabolism (invertebrates, mitochondrial)"/>
            <pathway-xref db="MetaCyc" id="PWY-7461" name="hydroxycinnamate sugar acid ester biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SCE-9696270" name="RND2 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-7727" name="docosahexaenoate biosynthesis IV (4-desaturase, mammals)"/>
            <pathway-xref db="Reactome" id="R-HSA-193634" name="Axonal growth inhibition (RHOA activation)"/>
            <pathway-xref db="Reactome" id="R-HSA-168179" name="Toll Like Receptor TLR1:TLR2 Cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-8873719" name="RAB geranylgeranylation"/>
            <pathway-xref db="MetaCyc" id="PWY-7945" name="2,2'-bis-(4-hydroxy-3-methybut-2-enyl)-beta,beta-carotene monoglucoside biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6312" name="barbaloin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-450321" name="JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1"/>
            <pathway-xref db="Reactome" id="R-DDI-5674135" name="MAP2K and MAPK activation"/>
            <pathway-xref db="MetaCyc" id="PWY-7653" name="griseofulvin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DDI-381676" name="Glucagon-like Peptide-1 (GLP1) regulates insulin secretion"/>
            <pathway-xref db="Reactome" id="R-HSA-216083" name="Integrin cell surface interactions"/>
            <pathway-xref db="MetaCyc" id="PWY-8012" name="mupirocin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9013424" name="RHOV GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-761" name="rhizobactin 1021 biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-1971475" name="A tetrasaccharide linker sequence is required for GAG synthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7673" name="fusarin C biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-4801" name="aloesone biosynthesis I"/>
            <pathway-xref db="Reactome" id="R-HSA-167021" name="PLC-gamma1 signalling"/>
            <pathway-xref db="MetaCyc" id="PWY-7171" name="flavonol acylglucoside biosynthesis II - isorhamnetin derivatives"/>
            <pathway-xref db="Reactome" id="R-DME-209968" name="Thyroxine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7563" name="bassianin and desmethylbassianin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SCE-9615933" name="Postmitotic nuclear pore complex (NPC) reformation"/>
            <pathway-xref db="MetaCyc" id="PWY-7214" name="baicalein degradation (hydrogen peroxide detoxification)"/>
            <pathway-xref db="MetaCyc" id="PWY-6672" name="cis-geranyl-CoA degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-9652282" name="Drug-mediated inhibition of ERBB2 signaling"/>
            <pathway-xref db="Reactome" id="R-SSC-168138" name="Toll Like Receptor 9 (TLR9) Cascade"/>
            <pathway-xref db="MetaCyc" id="PWY-7212" name="baicalein metabolism"/>
            <pathway-xref db="MetaCyc" id="PWY-6722" name="candicidin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-BTA-2022870" name="Chondroitin sulfate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-187042" name="TRKA activation by NGF"/>
            <pathway-xref db="Reactome" id="R-HSA-380259" name="Loss of Nlp from mitotic centrosomes"/>
            <pathway-xref db="MetaCyc" id="PWY-5094" name="naringenin glycoside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-5620916" name="VxPx cargo-targeting to cilium"/>
            <pathway-xref db="Reactome" id="R-CFA-2022870" name="Chondroitin sulfate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7679" name="anthocyanidin acylglucoside and acylsambubioside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-1461957" name="Beta defensins"/>
            <pathway-xref db="Reactome" id="R-HSA-9652282" name="Drug-mediated inhibition of ERBB2 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-418555" name="G alpha (s) signalling events"/>
            <pathway-xref db="Reactome" id="R-DRE-5620912" name="Anchoring of the basal body to the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-DRE-9013406" name="RHOQ GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-1461957" name="Beta defensins"/>
            <pathway-xref db="MetaCyc" id="PWY-7468" name="benzoyl-beta-D-glucopyranose biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-5223345" name="Miscellaneous transport and binding events"/>
            <pathway-xref db="MetaCyc" id="PWY-6958" name="icosapentaenoate biosynthesis I (lower eukaryotes)"/>
            <pathway-xref db="Reactome" id="R-HSA-5602410" name="TLR3 deficiency - HSE"/>
            <pathway-xref db="Reactome" id="R-XTR-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-HSA-444821" name="Relaxin receptors"/>
            <pathway-xref db="Reactome" id="R-HSA-168188" name="Toll Like Receptor TLR6:TLR2 Cascade"/>
            <pathway-xref db="Reactome" id="R-DDI-1632852" name="Macroautophagy"/>
            <pathway-xref db="Reactome" id="R-HSA-917937" name="Iron uptake and transport"/>
            <pathway-xref db="Reactome" id="R-HSA-373752" name="Netrin-1 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9637628" name="Modulation by Mtb of host immune system"/>
            <pathway-xref db="Reactome" id="R-HSA-166020" name="Transfer of LPS from LBP carrier to CD14"/>
            <pathway-xref db="MetaCyc" id="PWY-4421" name="curcumin glucoside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-166166" name="MyD88-independent TLR4 cascade"/>
            <pathway-xref db="MetaCyc" id="PWY-8257" name="Escherichia coli serotype O:52 O antigen biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5105" name="hesperitin glycoside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DRE-380320" name="Recruitment of NuMA to mitotic centrosomes"/>
            <pathway-xref db="MetaCyc" id="PWY-5875" name="staphyloxanthin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-4922" name="6-methoxymellein biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5475" name="pentagalloylglucose biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7922" name="protein O-mannosylation II (mammals, core M1 and core M2)"/>
            <pathway-xref db="Reactome" id="R-CEL-9013406" name="RHOQ GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-3595177" name="Defective CHSY1 causes TPBS"/>
            <pathway-xref db="MetaCyc" id="PWY-8157" name="avenanthramide biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6316" name="aromatic polyketides biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-381426" name="Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"/>
            <pathway-xref db="MetaCyc" id="PWY-5284" name="shisonin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6848" name="rutin degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7050" name="icosapentaenoate biosynthesis IV (bacteria)"/>
            <pathway-xref db="MetaCyc" id="PWY-7859" name="jasmonoyl-L-isoleucine inactivation"/>
            <pathway-xref db="Reactome" id="R-DRE-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7688" name="dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWYG-321" name="mycolate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9634285" name="Constitutive Signaling by Overexpressed ERBB2"/>
            <pathway-xref db="MetaCyc" id="PWY-8226" name="Escherichia coli serotype O:152 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-5223345" name="Miscellaneous transport and binding events"/>
            <pathway-xref db="MetaCyc" id="PWY-8084" name="daurichromenate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7713" name="nivalenol biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7412" name="mycinamicin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-141444" name="Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"/>
            <pathway-xref db="MetaCyc" id="PWY-8086" name="(S)-lactate fermentation to propanoate, acetate and hydrogen"/>
            <pathway-xref db="MetaCyc" id="PWY-7669" name="equisetin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-170984" name="ARMS-mediated activation"/>
            <pathway-xref db="Reactome" id="R-HSA-2243919" name="Crosslinking of collagen fibrils"/>
            <pathway-xref db="Reactome" id="R-MMU-380259" name="Loss of Nlp from mitotic centrosomes"/>
            <pathway-xref db="Reactome" id="R-DRE-917937" name="Iron uptake and transport"/>
            <pathway-xref db="Reactome" id="R-SCE-3108232" name="SUMO E3 ligases SUMOylate target proteins"/>
            <pathway-xref db="Reactome" id="R-HSA-3595174" name="Defective CHST14 causes EDS, musculocontractural type"/>
            <pathway-xref db="Reactome" id="R-HSA-8985586" name="SLIT2:ROBO1 increases RHOA activity"/>
            <pathway-xref db="MetaCyc" id="PWY-6922" name="L-Ndelta-acetylornithine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5846" name="colchicine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5313" name="superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)"/>
            <pathway-xref db="Reactome" id="R-HSA-3656243" name="Defective ST3GAL3 causes MCT12 and EIEE15"/>
            <pathway-xref db="Reactome" id="R-DRE-8854518" name="AURKA Activation by TPX2"/>
            <pathway-xref db="Reactome" id="R-HSA-9660826" name="Purinergic signaling in leishmaniasis infection"/>
            <pathway-xref db="MetaCyc" id="PWY-7470" name="phosphatidylcholine biosynthesis VII"/>
            <pathway-xref db="Reactome" id="R-MMU-5654687" name="Downstream signaling of activated FGFR1"/>
            <pathway-xref db="MetaCyc" id="PWY-7708" name="lyngbyatoxin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5342" name="ajugose biosynthesis I (galactinol-dependent)"/>
            <pathway-xref db="Reactome" id="R-DDI-5675482" name="Regulation of necroptotic cell death"/>
            <pathway-xref db="MetaCyc" id="PWY-6944" name="androstenedione degradation I (aerobic)"/>
            <pathway-xref db="Reactome" id="R-CFA-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-1236974" name="ER-Phagosome pathway"/>
            <pathway-xref db="MetaCyc" id="PWY-7946" name="sarcinaxanthin diglucoside biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7561" name="tenellin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SPO-199418" name="Negative regulation of the PI3K/AKT network"/>
            <pathway-xref db="MetaCyc" id="PWY-7661" name="protein N-glycosylation (Haloferax volcanii)"/>
            <pathway-xref db="MetaCyc" id="PWY-8209" name="Escherichia coli serotype O:15 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-214869" name="Phosphorylated CACT, DL and DIF homodimers dissociate from the TL receptor 'signalling complex'"/>
            <pathway-xref db="Reactome" id="R-DRE-9013148" name="CDC42 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-7884" name="lipoprotein posttranslational modification"/>
            <pathway-xref db="MetaCyc" id="PWY-7659" name="viridicatumtoxin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-84" name="resveratrol biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-140837" name="Intrinsic Pathway of Fibrin Clot Formation"/>
            <pathway-xref db="MetaCyc" id="PWY-7250" name="[2Fe-2S] iron-sulfur cluster biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-2243919" name="Crosslinking of collagen fibrils"/>
            <pathway-xref db="Reactome" id="R-HSA-168164" name="Toll Like Receptor 3 (TLR3) Cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-166016" name="Toll Like Receptor 4 (TLR4) Cascade"/>
            <pathway-xref db="Reactome" id="R-MMU-445989" name="TAK1 activates NFkB by phosphorylation and activation of IKKs complex"/>
            <pathway-xref db="Reactome" id="R-CEL-6803207" name="TP53 Regulates Transcription of Caspase Activators and Caspases"/>
            <pathway-xref db="MetaCyc" id="PWY-7728" name="(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)"/>
            <pathway-xref db="MetaCyc" id="PWY-7960" name="rhabduscin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-1474228" name="Degradation of the extracellular matrix"/>
            <pathway-xref db="MetaCyc" id="PWY-8250" name="Escherichia coli serotype O:9 O antigen biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7029" name="terminal olefins biosynthesis II"/>
            <pathway-xref db="MetaCyc" id="PWY-7670" name="fusaridione A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SPO-159231" name="Transport of Mature mRNA Derived from an Intronless Transcript"/>
            <pathway-xref db="Reactome" id="R-HSA-140534" name="Caspase activation via Death Receptors in the presence of ligand"/>
            <pathway-xref db="Reactome" id="R-CEL-3108232" name="SUMO E3 ligases SUMOylate target proteins"/>
            <pathway-xref db="Reactome" id="R-DME-159231" name="Transport of Mature mRNA Derived from an Intronless Transcript"/>
            <pathway-xref db="MetaCyc" id="PWY-6655" name="xanthan biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DDI-5673001" name="RAF/MAP kinase cascade"/>
            <pathway-xref db="Reactome" id="R-CEL-209968" name="Thyroxine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-5654687" name="Downstream signaling of activated FGFR1"/>
            <pathway-xref db="MetaCyc" id="PWY-8222" name="Escherichia coli serotype O:128 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-438066" name="Unblocking of NMDA receptors, glutamate binding and activation"/>
            <pathway-xref db="MetaCyc" id="PWY-5160" name="rose anthocyanin biosynthesis I (via cyanidin 5-O-beta-D-glucoside)"/>
            <pathway-xref db="MetaCyc" id="PWY-8207" name="Escherichia coli serotype O:85/Salmonella enterica serotype O:17 O antigen biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5381" name="NAD salvage (plants)"/>
            <pathway-xref db="MetaCyc" id="PWY-6010" name="apigenin glycosides biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-380270" name="Recruitment of mitotic centrosome proteins and complexes"/>
            <pathway-xref db="MetaCyc" id="PWY-7746" name="mycobacterial sulfolipid biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-187024" name="NGF-independant TRKA activation"/>
            <pathway-xref db="Reactome" id="R-HSA-428543" name="Inactivation of CDC42 and RAC1"/>
            <pathway-xref db="Reactome" id="R-HSA-6794361" name="Neurexins and neuroligins"/>
            <pathway-xref db="Reactome" id="R-HSA-9013973" name="TICAM1-dependent activation of IRF3/IRF7"/>
            <pathway-xref db="MetaCyc" id="PWY-8151" name="cholesterol degradation to androstenedione III (anaerobic)"/>
            <pathway-xref db="MetaCyc" id="PWY-7694" name="zwittermicin A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-159227" name="Transport of the SLBP independent Mature mRNA"/>
            <pathway-xref db="Reactome" id="R-RNO-166020" name="Transfer of LPS from LBP carrier to CD14"/>
            <pathway-xref db="MetaCyc" id="PWY-7002" name="4-hydroxyacetophenone degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7053" name="docosahexaenoate biosynthesis I (lower eukaryotes)"/>
            <pathway-xref db="Reactome" id="R-HSA-1227986" name="Signaling by ERBB2"/>
            <pathway-xref db="Reactome" id="R-MMU-9013406" name="RHOQ GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-166016" name="Toll Like Receptor 4 (TLR4) Cascade"/>
            <pathway-xref db="MetaCyc" id="PWY-7150" name="polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)"/>
            <pathway-xref db="Reactome" id="R-SPO-159236" name="Transport of Mature mRNA derived from an Intron-Containing Transcript"/>
            <pathway-xref db="Reactome" id="R-RNO-5654687" name="Downstream signaling of activated FGFR1"/>
            <pathway-xref db="Reactome" id="R-HSA-844456" name="The NLRP3 inflammasome"/>
            <pathway-xref db="Reactome" id="R-HSA-4608870" name="Asymmetric localization of PCP proteins"/>
            <pathway-xref db="Reactome" id="R-HSA-170968" name="Frs2-mediated activation"/>
            <pathway-xref db="MetaCyc" id="PWY-5139" name="pelargonidin conjugates biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6824" name="justicidin B biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7151" name="polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)"/>
            <pathway-xref db="MetaCyc" id="PWY-7819" name="poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-1227986" name="Signaling by ERBB2"/>
            <pathway-xref db="Reactome" id="R-HSA-983231" name="Factors involved in megakaryocyte development and platelet production"/>
            <pathway-xref db="MetaCyc" id="PWY-5477" name="gallotannin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-9648025" name="EML4 and NUDC in mitotic spindle formation"/>
            <pathway-xref db="Reactome" id="R-MMU-114608" name="Platelet degranulation"/>
            <pathway-xref db="Reactome" id="R-MMU-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-977606" name="Regulation of Complement cascade"/>
            <pathway-xref db="MetaCyc" id="PWY-8208" name="Salmonella enterica serotype O:6,7 O antigen biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7487" name="(+)-secoisolariciresinol diglucoside biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5913" name="partial TCA cycle (obligate autotrophs)"/>
            <pathway-xref db="Reactome" id="R-RNO-159231" name="Transport of Mature mRNA Derived from an Intronless Transcript"/>
            <pathway-xref db="Reactome" id="R-HSA-450302" name="activated TAK1 mediates p38 MAPK activation"/>
            <pathway-xref db="Reactome" id="R-BTA-2022854" name="Keratan sulfate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-8849932" name="Synaptic adhesion-like molecules"/>
            <pathway-xref db="MetaCyc" id="PWY-8243" name="colanic acid (Escherichia coli K12) biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7599" name="anditomin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-844456" name="The NLRP3 inflammasome"/>
            <pathway-xref db="Reactome" id="R-MMU-177504" name="Retrograde neurotrophin signalling"/>
            <pathway-xref db="Reactome" id="R-RNO-5673001" name="RAF/MAP kinase cascade"/>
            <pathway-xref db="MetaCyc" id="PWY-7401" name="crotonate fermentation (to acetate and cyclohexane carboxylate)"/>
            <pathway-xref db="Reactome" id="R-HSA-198203" name="PI3K/AKT activation"/>
            <pathway-xref db="Reactome" id="R-DDI-1660516" name="Synthesis of PIPs at the early endosome membrane"/>
            <pathway-xref db="Reactome" id="R-HSA-114608" name="Platelet degranulation"/>
            <pathway-xref db="Reactome" id="R-MMU-199418" name="Negative regulation of the PI3K/AKT network"/>
            <pathway-xref db="MetaCyc" id="PWY-7816" name="poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)"/>
            <pathway-xref db="Reactome" id="R-HSA-428540" name="Activation of RAC1"/>
            <pathway-xref db="MetaCyc" id="PWY-6415" name="L-ascorbate biosynthesis V (euglena, D-galacturonate pathway)"/>
            <pathway-xref db="Reactome" id="R-DME-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="MetaCyc" id="PWY-8045" name="cylindrospermopsin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6679" name="jadomycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-168142" name="Toll Like Receptor 10 (TLR10) Cascade"/>
            <pathway-xref db="MetaCyc" id="PWY-5774" name="saponin biosynthesis IV"/>
            <pathway-xref db="Reactome" id="R-MMU-450302" name="activated TAK1 mediates p38 MAPK activation"/>
            <pathway-xref db="Reactome" id="R-HSA-198745" name="Signalling to STAT3"/>
            <pathway-xref db="Reactome" id="R-HSA-5603041" name="IRAK4 deficiency (TLR2/4)"/>
            <pathway-xref db="Reactome" id="R-MMU-9020702" name="Interleukin-1 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-83" name="monolignol glucosides biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7168" name="flavonol acylglucoside biosynthesis I - kaempferol derivatives"/>
            <pathway-xref db="MetaCyc" id="PWY-7623" name="astaxanthin dirhamnoside biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7719" name="CMP-diacetamido-8-epilegionaminic acid biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7690" name="holomycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-214844" name="DL and DIF homodimers complexed with CACT are all phosphorylated in the TL receptor 'signalling complex'"/>
            <pathway-xref db="MetaCyc" id="PWY-5822" name="trichloroethene degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-5392" name="reductive TCA cycle II"/>
            <pathway-xref db="Reactome" id="R-BTA-5223345" name="Miscellaneous transport and binding events"/>
            <pathway-xref db="MetaCyc" id="PWY-5307" name="gentiodelphin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-2022857" name="Keratan sulfate degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-9648025" name="EML4 and NUDC in mitotic spindle formation"/>
            <pathway-xref db="MetaCyc" id="PWY-5380" name="A series fagopyritols biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-216083" name="Integrin cell surface interactions"/>
            <pathway-xref db="MetaCyc" id="PWY-5660" name="taxol biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8000" name="vitamin K degradation"/>
            <pathway-xref db="Reactome" id="R-RNO-199418" name="Negative regulation of the PI3K/AKT network"/>
            <pathway-xref db="MetaCyc" id="PWY-2902" name="cytokinin-O-glucosides biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8036" name="chaxamycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-937041" name="IKK complex recruitment mediated by RIP1"/>
            <pathway-xref db="Reactome" id="R-MMU-2024101" name="CS/DS degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-430116" name="GP1b-IX-V activation signalling"/>
            <pathway-xref db="MetaCyc" id="PWY-7743" name="dimycocerosyl triglycosyl phenolphthiocerol biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-5689901" name="Metalloprotease DUBs"/>
            <pathway-xref db="Reactome" id="R-HSA-2024101" name="CS/DS degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-8237" name="Escherichia coli serotype O:1B/Salmonella enterica serotype O:42 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-9013026" name="RHOB GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-7696" name="citreoisocoumarin and bikisocoumarin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7342" name="superpathway of nicotine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-1971475" name="A tetrasaccharide linker sequence is required for GAG synthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-6804115" name="TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"/>
            <pathway-xref db="Reactome" id="R-MMU-5689901" name="Metalloprotease DUBs"/>
            <pathway-xref db="MetaCyc" id="PWY-6971" name="oleandomycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-9034013" name="NTF3 activates NTRK3 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-9013026" name="RHOB GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-6797" name="6-hydroxymethyl-dihydropterin diphosphate biosynthesis II (Methanocaldococcus)"/>
            <pathway-xref db="Reactome" id="R-BTA-3000178" name="ECM proteoglycans"/>
            <pathway-xref db="Reactome" id="R-MMU-429947" name="Deadenylation of mRNA"/>
            <pathway-xref db="Reactome" id="R-MMU-9696264" name="RND3 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-7740" name="beta-D-mannosyl phosphomycoketide biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-9696270" name="RND2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-937072" name="TRAF6-mediated induction of TAK1 complex within TLR4 complex"/>
            <pathway-xref db="Reactome" id="R-HSA-187706" name="Signalling to p38 via RIT and RIN"/>
            <pathway-xref db="Reactome" id="R-CEL-8951664" name="Neddylation"/>
            <pathway-xref db="MetaCyc" id="PWY-8233" name="Escherichia coli serotype O:169 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DDI-1660499" name="Synthesis of PIPs at the plasma membrane"/>
            <pathway-xref db="MetaCyc" id="PWY-7592" name="arachidonate biosynthesis III (6-desaturase, mammals)"/>
            <pathway-xref db="MetaCyc" id="PWY-8217" name="Escherichia coli serotype O:55/Salmonella enterica serotype O:50 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-GGA-9032759" name="NTRK2 activates RAC1"/>
            <pathway-xref db="Reactome" id="R-HSA-168927" name="TICAM1, RIP1-mediated IKK complex recruitment"/>
            <pathway-xref db="Reactome" id="R-HSA-8849932" name="Synaptic adhesion-like molecules"/>
            <pathway-xref db="MetaCyc" id="PWY-8206" name="Salmonella enterica serotype O:18 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9660821" name="ADORA2B mediated anti-inflammatory cytokines production"/>
            <pathway-xref db="Reactome" id="R-MMU-109704" name="PI3K Cascade"/>
            <pathway-xref db="MetaCyc" id="PWY-6762" name="salicylate glucosides biosynthesis IV"/>
            <pathway-xref db="Reactome" id="R-RNO-388844" name="Receptor-type tyrosine-protein phosphatases"/>
            <pathway-xref db="MetaCyc" id="PWY-8152" name="androstenedione degradation II (anaerobic)"/>
            <pathway-xref db="MetaCyc" id="PWY-5048" name="rosmarinic acid biosynthesis I"/>
            <pathway-xref db="MetaCyc" id="PWY-361" name="phenylpropanoid biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7897" name="flavonoid di-C-glucosylation"/>
            <pathway-xref db="Reactome" id="R-HSA-9664565" name="Signaling by ERBB2 KD Mutants"/>
            <pathway-xref db="Reactome" id="R-HSA-1971475" name="A tetrasaccharide linker sequence is required for GAG synthesis"/>
            <pathway-xref db="Reactome" id="R-BTA-114608" name="Platelet degranulation"/>
            <pathway-xref db="Reactome" id="R-HSA-380284" name="Loss of proteins required for interphase microtubule organization from the centrosome"/>
            <pathway-xref db="MetaCyc" id="PWY-8055" name="palmitoyl ethanolamide biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DRE-2022857" name="Keratan sulfate degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7539" name="6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia)"/>
            <pathway-xref db="MetaCyc" id="PWY-7570" name="blasticidin S biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-5617472" name="Activation of anterior HOX genes in hindbrain development during early embryogenesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6442" name="spermidine hydroxycinnamic acid conjugates biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5984" name="rifamycin B biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DDI-983231" name="Factors involved in megakaryocyte development and platelet production"/>
            <pathway-xref db="Reactome" id="R-HSA-380270" name="Recruitment of mitotic centrosome proteins and complexes"/>
            <pathway-xref db="Reactome" id="R-SPO-159227" name="Transport of the SLBP independent Mature mRNA"/>
            <pathway-xref db="MetaCyc" id="PWY-7450" name="anthocyanidin modification (Arabidopsis)"/>
            <pathway-xref db="MetaCyc" id="PWY-5469" name="sesamin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5926" name="afrormosin conjugates interconversion"/>
            <pathway-xref db="MetaCyc" id="PWY-8253" name="Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7354" name="aclacinomycin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7145" name="genistin gentiobioside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-975163" name="IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation"/>
            <pathway-xref db="MetaCyc" id="PWY-7921" name="protein O-mannosylation I (yeast)"/>
            <pathway-xref db="MetaCyc" id="PWY-7530" name="Escherichia coli serotype O:104 O antigen biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8205" name="Escherichia coli serotype O:77/Salmonella enterica serotype O:6,14 O antigen biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7491" name="podophyllotoxin glucosides metabolism"/>
            <pathway-xref db="Reactome" id="R-HSA-72163" name="mRNA Splicing - Major Pathway"/>
            <pathway-xref db="Reactome" id="R-HSA-9609736" name="Assembly and cell surface presentation of NMDA receptors"/>
            <pathway-xref db="MetaCyc" id="PWY-5268" name="salvianin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-450520" name="HuR (ELAVL1) binds and stabilizes mRNA"/>
            <pathway-xref db="Reactome" id="R-RNO-2022923" name="Dermatan sulfate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7463" name="N-methylanthraniloyl-beta-D-glucopyranose biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7166" name="kaempferide triglycoside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-5689896" name="Ovarian tumor domain proteases"/>
            <pathway-xref db="Reactome" id="R-MMU-163125" name="Post-translational modification: synthesis of GPI-anchored proteins"/>
            <pathway-xref db="Reactome" id="R-HSA-1810476" name="RIP-mediated NFkB activation via ZBP1"/>
            <pathway-xref db="Reactome" id="R-RNO-1679131" name="Trafficking and processing of endosomal TLR"/>
            <pathway-xref db="MetaCyc" id="PWY-6673" name="caffeoylglucarate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9707564" name="Cytoprotection by HMOX1"/>
            <pathway-xref db="MetaCyc" id="PWY-6799" name="fatty acid biosynthesis initiation (plant mitochondria)"/>
            <pathway-xref db="Reactome" id="R-DRE-2565942" name="Regulation of PLK1 Activity at G2/M Transition"/>
            <pathway-xref db="MetaCyc" id="PWY-7658" name="protein N-glycosylation (Methanococcus voltae)"/>
            <pathway-xref db="MetaCyc" id="PWY-7656" name="Spodoptera littoralis pheromone biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6453" name="stigma estolide biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-3560801" name="Defective B3GAT3 causes JDSSDHD"/>
            <pathway-xref db="MetaCyc" id="PWY-8234" name="Escherichia coli serotype O:183/Shigella boydii serotype O:10 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-2022870" name="Chondroitin sulfate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7692" name="bikaverin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7811" name="6-methylpretetramide biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9603381" name="Activated NTRK3 signals through PI3K"/>
            <pathway-xref db="Reactome" id="R-HSA-9034013" name="NTF3 activates NTRK3 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-6920" name="6-gingerol analog biosynthesis (engineered)"/>
            <pathway-xref db="Reactome" id="R-HSA-5602566" name="TICAM1 deficiency - HSE"/>
            <pathway-xref db="Reactome" id="R-HSA-6804115" name="TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"/>
            <pathway-xref db="MetaCyc" id="PWY-7602" name="icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)"/>
            <pathway-xref db="Reactome" id="R-CFA-2022923" name="Dermatan sulfate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7706" name="dapdiamides biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-168638" name="NOD1/2 Signaling Pathway"/>
            <pathway-xref db="Reactome" id="R-SSC-1679131" name="Trafficking and processing of endosomal TLR"/>
            <pathway-xref db="MetaCyc" id="PWY-7988" name="baumannoferrin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7318" name="dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7986" name="anguibactin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9696270" name="RND2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-SSC-109704" name="PI3K Cascade"/>
            <pathway-xref db="MetaCyc" id="PWY-6147" name="6-hydroxymethyl-dihydropterin diphosphate biosynthesis I"/>
            <pathway-xref db="MetaCyc" id="PWY-7687" name="stipitatate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5757" name="fosfomycin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6379" name="alcaligin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-214874" name="PLL kinase binds to TUB in the TL receptor 'signalling complex'"/>
            <pathway-xref db="MetaCyc" id="PWY-7074" name="phenylethanol glycoconjugate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9696264" name="RND3 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-CFA-1679131" name="Trafficking and processing of endosomal TLR"/>
            <pathway-xref db="MetaCyc" id="PWY-7206" name="pyrimidine deoxyribonucleotides dephosphorylation"/>
            <pathway-xref db="Reactome" id="R-RNO-159227" name="Transport of the SLBP independent Mature mRNA"/>
            <pathway-xref db="Reactome" id="R-HSA-8951664" name="Neddylation"/>
            <pathway-xref db="MetaCyc" id="PWY-1981" name="indole-3-acetate inactivation III"/>
            <pathway-xref db="MetaCyc" id="PWY-7730" name="T-2 toxin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DDI-5673000" name="RAF activation"/>
            <pathway-xref db="MetaCyc" id="PWY-8204" name="Salmonella enterica serotype O:54 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-5603037" name="IRAK4 deficiency (TLR5)"/>
            <pathway-xref db="Reactome" id="R-RNO-9028731" name="Activated NTRK2 signals through FRS2 and FRS3"/>
            <pathway-xref db="MetaCyc" id="PWY-7407" name="aurachin A, B, C and D biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6930" name="phenolic malonylglucosides biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6627" name="salinosporamide A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-141444" name="Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"/>
            <pathway-xref db="Reactome" id="R-HSA-9013149" name="RAC1 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-7213" name="wogonin metabolism"/>
            <pathway-xref db="Reactome" id="R-DDI-5675221" name="Negative regulation of MAPK pathway"/>
            <pathway-xref db="Reactome" id="R-MMU-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-HSA-9615933" name="Postmitotic nuclear pore complex (NPC) reformation"/>
            <pathway-xref db="Reactome" id="R-HSA-9013423" name="RAC3 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-CEL-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="MetaCyc" id="PWY-6310" name="aloesone biosynthesis II"/>
            <pathway-xref db="MetaCyc" id="PWY-7405" name="aurachin RE biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SCE-199418" name="Negative regulation of the PI3K/AKT network"/>
            <pathway-xref db="Reactome" id="R-HSA-428542" name="Regulation of commissural axon pathfinding by SLIT and ROBO"/>
            <pathway-xref db="Reactome" id="R-DME-4615885" name="SUMOylation of DNA replication proteins"/>
            <pathway-xref db="MetaCyc" id="PWY-7191" name="kaempferol diglycoside biosynthesis (pollen-specific)"/>
            <pathway-xref db="MetaCyc" id="PWY-6657" name="polyhydroxydecanoate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6024" name="isovitexin glycosides biosynthesis"/>
            <pathway-xref db="Reactome" id="R-XTR-2243919" name="Crosslinking of collagen fibrils"/>
            <pathway-xref db="MetaCyc" id="PWY-8242" name="Escherichia coli serotype O:51/Salmonella enterica serotype O:57 O antigen biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7815" name="poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)"/>
            <pathway-xref db="MetaCyc" id="PWY-5666" name="alpha-solanine/alpha-chaconine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-159236" name="Transport of Mature mRNA derived from an Intron-Containing Transcript"/>
            <pathway-xref db="Reactome" id="R-HSA-380320" name="Recruitment of NuMA to mitotic centrosomes"/>
            <pathway-xref db="Reactome" id="R-HSA-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-5794" name="malonate degradation I (biotin-independent)"/>
            <pathway-xref db="Reactome" id="R-HSA-9025046" name="NTF3 activates NTRK2 (TRKB) signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-2901" name="cytokinins 9-N-glucoside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-3000178" name="ECM proteoglycans"/>
            <pathway-xref db="Reactome" id="R-HSA-446388" name="Regulation of cytoskeletal remodeling and cell spreading by IPP complex components"/>
            <pathway-xref db="Reactome" id="R-MMU-166166" name="MyD88-independent TLR4 cascade"/>
            <pathway-xref db="Reactome" id="R-MMU-9603381" name="Activated NTRK3 signals through PI3K"/>
            <pathway-xref db="MetaCyc" id="PWY-7838" name="globo-series glycosphingolipids biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7633" name="calycosin 7-O-glucoside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-9013423" name="RAC3 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-7129" name="quercetin glucoside biosynthesis (Allium)"/>
            <pathway-xref db="Reactome" id="R-HSA-9020702" name="Interleukin-1 signaling"/>
            <pathway-xref db="Reactome" id="R-DRE-380259" name="Loss of Nlp from mitotic centrosomes"/>
            <pathway-xref db="MetaCyc" id="PWY-7712" name="deoxynivalenol biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-193634" name="Axonal growth inhibition (RHOA activation)"/>
            <pathway-xref db="Reactome" id="R-MMU-917937" name="Iron uptake and transport"/>
            <pathway-xref db="Reactome" id="R-MMU-9013149" name="RAC1 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-7984" name="acinetobactin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-5689896" name="Ovarian tumor domain proteases"/>
            <pathway-xref db="MetaCyc" id="PWY-5321" name="quercetin glycoside biosynthesis (Arabidopsis)"/>
            <pathway-xref db="MetaCyc" id="PWY-8235" name="Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-6794361" name="Neurexins and neuroligins"/>
            <pathway-xref db="Reactome" id="R-MMU-418555" name="G alpha (s) signalling events"/>
            <pathway-xref db="MetaCyc" id="PWY-5466" name="matairesinol biosynthesis"/>
          </entry>
          <signature-library-release library="PFAM" version="34.0"/>
        </signature>
        <model-ac>PF13855</model-ac>
        <locations>
          <hmmer3-location env-end="190" env-start="133" post-processed="true" score="30.2" evalue="2.8E-7" hmm-start="3" hmm-end="61" hmm-length="61" hmm-bounds="C_TERMINAL_COMPLETE" start="134" end="190">
            <location-fragments>
              <hmmer3-location-fragment start="134" end="190" dc-status="CONTINUOUS"/>
            </location-fragments>
          </hmmer3-location>
        </locations>
      </hmmer3-match>
      <hmmer3-match evalue="5.7E-85" score="285.6">
        <signature ac="G3DSA:3.80.10.10" name="Ribonuclease Inhibitor">
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            <pathway-xref db="Reactome" id="R-HSA-2565942" name="Regulation of PLK1 Activity at G2/M Transition"/>
            <pathway-xref db="Reactome" id="R-HSA-5673001" name="RAF/MAP kinase cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-187042" name="TRKA activation by NGF"/>
            <pathway-xref db="Reactome" id="R-MMU-5620912" name="Anchoring of the basal body to the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-MMU-2565942" name="Regulation of PLK1 Activity at G2/M Transition"/>
            <pathway-xref db="MetaCyc" id="PWY-7049" name="icosapentaenoate biosynthesis II (6-desaturase, mammals)"/>
            <pathway-xref db="Reactome" id="R-HSA-1474228" name="Degradation of the extracellular matrix"/>
            <pathway-xref db="Reactome" id="R-HSA-5620912" name="Anchoring of the basal body to the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-DME-193634" name="Axonal growth inhibition (RHOA activation)"/>
            <pathway-xref db="Reactome" id="R-RNO-163210" name="Formation of ATP by chemiosmotic coupling"/>
            <pathway-xref db="MetaCyc" id="PWY-8143" name="L-ascorbate biosynthesis VII (plants, D-galacturonate pathway)"/>
            <pathway-xref db="Reactome" id="R-RNO-140837" name="Intrinsic Pathway of Fibrin Clot Formation"/>
            <pathway-xref db="Reactome" id="R-RNO-6794361" name="Neurexins and neuroligins"/>
            <pathway-xref db="Reactome" id="R-RNO-76009" name="Platelet Aggregation (Plug Formation)"/>
            <pathway-xref db="MetaCyc" id="PWY-7465" name="3,3'-thiodipropanoate degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-72163" name="mRNA Splicing - Major Pathway"/>
            <pathway-xref db="Reactome" id="R-DDI-1660517" name="Synthesis of PIPs at the late endosome membrane"/>
            <pathway-xref db="Reactome" id="R-HSA-9617324" name="Negative regulation of NMDA receptor-mediated neuronal transmission"/>
            <pathway-xref db="Reactome" id="R-MMU-9706019" name="RHOBTB3 ATPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-7521" name="3-(4-sulfophenyl)butanoate degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-390471" name="Association of TriC/CCT with target proteins during biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7714" name="harzianum A and trichodermin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5987" name="sorgoleone biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7606" name="docosahexaenoate biosynthesis III (6-desaturase, mammals)"/>
            <pathway-xref db="Reactome" id="R-HSA-8854050" name="FBXL7 down-regulates AURKA during mitotic entry and in early mitosis"/>
            <pathway-xref db="Reactome" id="R-DRE-3134975" name="Regulation of innate immune responses to cytosolic DNA"/>
            <pathway-xref db="Reactome" id="R-MMU-9615933" name="Postmitotic nuclear pore complex (NPC) reformation"/>
            <pathway-xref db="Reactome" id="R-HSA-9034864" name="Activated NTRK3 signals through RAS"/>
            <pathway-xref db="Reactome" id="R-MMU-8854050" name="FBXL7 down-regulates AURKA during mitotic entry and in early mitosis"/>
            <pathway-xref db="MetaCyc" id="PWY-8053" name="anandamide biosynthesis II"/>
            <pathway-xref db="MetaCyc" id="PWY-8049" name="pederin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-170984" name="ARMS-mediated activation"/>
            <pathway-xref db="Reactome" id="R-HSA-76009" name="Platelet Aggregation (Plug Formation)"/>
            <pathway-xref db="Reactome" id="R-MMU-68877" name="Mitotic Prometaphase"/>
            <pathway-xref db="Reactome" id="R-RNO-5223345" name="Miscellaneous transport and binding events"/>
            <pathway-xref db="MetaCyc" id="PWY-7612" name="chaetoglobosin A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-8951664" name="Neddylation"/>
            <pathway-xref db="Reactome" id="R-HSA-9026357" name="NTF4 activates NTRK2 (TRKB) signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-159230" name="Transport of the SLBP Dependant Mature mRNA"/>
            <pathway-xref db="Reactome" id="R-CEL-9010553" name="Regulation of expression of SLITs and ROBOs"/>
            <pathway-xref db="MetaCyc" id="PWY-6749" name="CMP-legionaminate biosynthesis I"/>
            <pathway-xref db="Reactome" id="R-MMU-5673001" name="RAF/MAP kinase cascade"/>
            <pathway-xref db="Reactome" id="R-CEL-5673000" name="RAF activation"/>
            <pathway-xref db="Reactome" id="R-MMU-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7585" name="docosahexaenoate biosynthesis II (bacteria)"/>
            <pathway-xref db="MetaCyc" id="PWY-7695" name="aurofusarin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-170968" name="Frs2-mediated activation"/>
            <pathway-xref db="MetaCyc" id="PWY-5353" name="arachidonate biosynthesis I (6-desaturase, lower eukaryotes)"/>
            <pathway-xref db="Reactome" id="R-HSA-4420332" name="Defective B3GALT6 causes EDSP2 and SEMDJL1"/>
            <pathway-xref db="Reactome" id="R-MMU-168138" name="Toll Like Receptor 9 (TLR9) Cascade"/>
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            <pathway-xref db="MetaCyc" id="PWY-6955" name="lincomycin A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DDI-8876198" name="RAB GEFs exchange GTP for GDP on RABs"/>
            <pathway-xref db="MetaCyc" id="PWY-8032" name="chloramphenicol biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6841" name="homophytochelatin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-5682910" name="LGI-ADAM interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-159236" name="Transport of Mature mRNA derived from an Intron-Containing Transcript"/>
            <pathway-xref db="MetaCyc" id="PWY-7448" name="galloylated catechin biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-MMU-159231" name="Transport of Mature mRNA Derived from an Intronless Transcript"/>
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            <pathway-xref db="MetaCyc" id="PWY-7543" name="5-N-acetylardeemin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-442982" name="Ras activation upon Ca2+ influx through NMDA receptor"/>
            <pathway-xref db="Reactome" id="R-HSA-9679191" name="Potential therapeutics for SARS"/>
            <pathway-xref db="MetaCyc" id="PWY-7987" name="vanchrobactin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-BTA-390522" name="Striated Muscle Contraction"/>
            <pathway-xref db="Reactome" id="R-HSA-5682910" name="LGI-ADAM interactions"/>
            <pathway-xref db="Reactome" id="R-BTA-2022857" name="Keratan sulfate degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-6803205" name="TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain"/>
            <pathway-xref db="MetaCyc" id="PWY-8247" name="(Kdo)2-lipid A biosynthesis (P. gingivalis)"/>
            <pathway-xref db="Reactome" id="R-CEL-445355" name="Smooth Muscle Contraction"/>
            <pathway-xref db="Reactome" id="R-HSA-9665247" name="Resistance of ERBB2 KD mutants to osimertinib"/>
            <pathway-xref db="Reactome" id="R-MMU-844455" name="The NLRP1 inflammasome"/>
            <pathway-xref db="Reactome" id="R-RNO-177504" name="Retrograde neurotrophin signalling"/>
            <pathway-xref db="Reactome" id="R-HSA-429947" name="Deadenylation of mRNA"/>
            <pathway-xref db="MetaCyc" id="PWY-7547" name="prodigiosin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8106" name="queuosine biosynthesis III (queuosine salvage)"/>
            <pathway-xref db="MetaCyc" id="PWY-7660" name="tryptoquialanine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-936964" name="Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon"/>
            <pathway-xref db="Reactome" id="R-MMU-376176" name="Signaling by ROBO receptors"/>
            <pathway-xref db="Reactome" id="R-CEL-72163" name="mRNA Splicing - Major Pathway"/>
            <pathway-xref db="Reactome" id="R-CFA-8951664" name="Neddylation"/>
            <pathway-xref db="Reactome" id="R-XTR-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-BTA-2024101" name="CS/DS degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-187577" name="SCF(Skp2)-mediated degradation of p27/p21"/>
            <pathway-xref db="MetaCyc" id="PWY-7419" name="FR-900098 and FR-33289 antibiotics biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-8949613" name="Cristae formation"/>
            <pathway-xref db="Reactome" id="R-RNO-9013149" name="RAC1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-140534" name="Caspase activation via Death Receptors in the presence of ligand"/>
            <pathway-xref db="MetaCyc" id="PWY-7950" name="diadinoxanthin and fucoxanthin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-9707616" name="Heme signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-450520" name="HuR (ELAVL1) binds and stabilizes mRNA"/>
            <pathway-xref db="MetaCyc" id="PWY-7930" name="pyoluteorin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6842" name="glutathione-mediated detoxification II"/>
            <pathway-xref db="Reactome" id="R-MMU-937041" name="IKK complex recruitment mediated by RIP1"/>
            <pathway-xref db="Reactome" id="R-HSA-2022854" name="Keratan sulfate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-2022854" name="Keratan sulfate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-4641263" name="Regulation of FZD by ubiquitination"/>
            <pathway-xref db="Reactome" id="R-RNO-9032759" name="NTRK2 activates RAC1"/>
            <pathway-xref db="MetaCyc" id="PWY-7982" name="pinoresinol degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-168638" name="NOD1/2 Signaling Pathway"/>
            <pathway-xref db="Reactome" id="R-MMU-3108232" name="SUMO E3 ligases SUMOylate target proteins"/>
            <pathway-xref db="Reactome" id="R-DDI-5213460" name="RIPK1-mediated regulated necrosis"/>
            <pathway-xref db="MetaCyc" id="PWY-6463" name="peptidoglycan cross-bridge biosynthesis IV (Weissella viridescens)"/>
            <pathway-xref db="Reactome" id="R-HSA-9014325" name="TICAM1,TRAF6-dependent induction of TAK1 complex"/>
            <pathway-xref db="Reactome" id="R-HSA-177504" name="Retrograde neurotrophin signalling"/>
            <pathway-xref db="MetaCyc" id="PWY-7817" name="type I lipoteichoic acid biosynthesis (S. aureus)"/>
            <pathway-xref db="Reactome" id="R-DME-450520" name="HuR (ELAVL1) binds and stabilizes mRNA"/>
            <pathway-xref db="Reactome" id="R-MMU-380320" name="Recruitment of NuMA to mitotic centrosomes"/>
            <pathway-xref db="Reactome" id="R-MMU-428890" name="Role of ABL in ROBO-SLIT signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-68877" name="Mitotic Prometaphase"/>
            <pathway-xref db="Reactome" id="R-SPO-8949613" name="Cristae formation"/>
            <pathway-xref db="Reactome" id="R-MMU-983231" name="Factors involved in megakaryocyte development and platelet production"/>
            <pathway-xref db="Reactome" id="R-HSA-165054" name="Rev-mediated nuclear export of HIV RNA"/>
            <pathway-xref db="Reactome" id="R-CFA-1474228" name="Degradation of the extracellular matrix"/>
            <pathway-xref db="Reactome" id="R-HSA-390522" name="Striated Muscle Contraction"/>
            <pathway-xref db="Reactome" id="R-RNO-390522" name="Striated Muscle Contraction"/>
            <pathway-xref db="Reactome" id="R-HSA-445355" name="Smooth Muscle Contraction"/>
            <pathway-xref db="Reactome" id="R-CEL-438066" name="Unblocking of NMDA receptors, glutamate binding and activation"/>
            <pathway-xref db="Reactome" id="R-HSA-5686938" name="Regulation of TLR by endogenous ligand"/>
            <pathway-xref db="Reactome" id="R-MMU-168181" name="Toll Like Receptor 7/8 (TLR7/8) Cascade"/>
            <pathway-xref db="Reactome" id="R-RNO-198203" name="PI3K/AKT activation"/>
            <pathway-xref db="Reactome" id="R-HSA-9665244" name="Resistance of ERBB2 KD mutants to sapitinib"/>
            <pathway-xref db="Reactome" id="R-MMU-68949" name="Orc1 removal from chromatin"/>
            <pathway-xref db="Reactome" id="R-HSA-3108232" name="SUMO E3 ligases SUMOylate target proteins"/>
            <pathway-xref db="Reactome" id="R-HSA-8876493" name="InlA-mediated entry of Listeria monocytogenes into host cells"/>
            <pathway-xref db="Reactome" id="R-DRE-6804115" name="TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"/>
            <pathway-xref db="Reactome" id="R-HSA-9660537" name="Signaling by MRAS-complex mutants"/>
            <pathway-xref db="MetaCyc" id="PWY-7887" name="protein SAMPylation and SAMP-mediated thiolation"/>
            <pathway-xref db="Reactome" id="R-HSA-9707616" name="Heme signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-8873719" name="RAB geranylgeranylation"/>
            <pathway-xref db="MetaCyc" id="PWY-6320" name="phaselate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6407" name="yersiniabactin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-5686938" name="Regulation of TLR by endogenous ligand"/>
            <pathway-xref db="Reactome" id="R-GGA-9026527" name="Activated NTRK2 signals through PLCG1"/>
            <pathway-xref db="Reactome" id="R-HSA-140837" name="Intrinsic Pathway of Fibrin Clot Formation"/>
            <pathway-xref db="MetaCyc" id="PWY-5975" name="furaneol and mesifurane biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-214863" name="Adaptor protein complex binds to TL receptor at the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-MMU-5663220" name="RHO GTPases Activate Formins"/>
            <pathway-xref db="MetaCyc" id="PWY-7415" name="tylosin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-5602571" name="TRAF3 deficiency - HSE"/>
            <pathway-xref db="MetaCyc" id="PWY-6946" name="cholesterol degradation to androstenedione II (cholesterol dehydrogenase)"/>
            <pathway-xref db="Reactome" id="R-RNO-844456" name="The NLRP3 inflammasome"/>
            <pathway-xref db="Reactome" id="R-HSA-5663220" name="RHO GTPases Activate Formins"/>
            <pathway-xref db="Reactome" id="R-MMU-76009" name="Platelet Aggregation (Plug Formation)"/>
            <pathway-xref db="Reactome" id="R-MMU-9708530" name="Regulation of BACH1 activity"/>
            <pathway-xref db="Reactome" id="R-HSA-9024909" name="BDNF activates NTRK2 (TRKB) signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-438066" name="Unblocking of NMDA receptors, glutamate binding and activation"/>
            <pathway-xref db="Reactome" id="R-CFA-1971475" name="A tetrasaccharide linker sequence is required for GAG synthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-163210" name="Formation of ATP by chemiosmotic coupling"/>
            <pathway-xref db="Reactome" id="R-MMU-177929" name="Signaling by EGFR"/>
            <pathway-xref db="MetaCyc" id="PWY-1921" name="indole-3-acetate activation II"/>
            <pathway-xref db="Reactome" id="R-DRE-5673000" name="RAF activation"/>
            <pathway-xref db="MetaCyc" id="PWY-8082" name="glycine lipid biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-975138" name="TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation"/>
            <pathway-xref db="MetaCyc" id="PWY-7565" name="aspyridone A biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7769" name="phosalacine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-428890" name="Role of ABL in ROBO-SLIT signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-9603381" name="Activated NTRK3 signals through PI3K"/>
            <pathway-xref db="Reactome" id="R-HSA-199418" name="Negative regulation of the PI3K/AKT network"/>
            <pathway-xref db="Reactome" id="R-HSA-9708530" name="Regulation of BACH1 activity"/>
            <pathway-xref db="MetaCyc" id="PWY-7445" name="luteolin triglucuronide degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-444821" name="Relaxin receptors"/>
            <pathway-xref db="MetaCyc" id="PWY-5903" name="bacillibactin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-6804115" name="TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"/>
            <pathway-xref db="MetaCyc" id="PWY-7689" name="8-O-methylfusarubin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-438066" name="Unblocking of NMDA receptors, glutamate binding and activation"/>
            <pathway-xref db="Reactome" id="R-HSA-9706019" name="RHOBTB3 ATPase cycle"/>
            <pathway-xref db="Reactome" id="R-DME-209442" name="Formation of the trans-membrane 'signalling complex'"/>
            <pathway-xref db="Reactome" id="R-RNO-9013423" name="RAC3 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-170984" name="ARMS-mediated activation"/>
            <pathway-xref db="Reactome" id="R-HSA-1679131" name="Trafficking and processing of endosomal TLR"/>
            <pathway-xref db="MetaCyc" id="PWY-6945" name="cholesterol degradation to androstenedione I (cholesterol oxidase)"/>
            <pathway-xref db="MetaCyc" id="PWY-7464" name="cyanidin 3,7-diglucoside polyacylation biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-8941413" name="Events associated with phagocytolytic activity of PMN cells"/>
            <pathway-xref db="MetaCyc" id="PWY-7726" name="(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)"/>
            <pathway-xref db="Reactome" id="R-SCE-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-MMU-430116" name="GP1b-IX-V activation signalling"/>
            <pathway-xref db="Reactome" id="R-BTA-450520" name="HuR (ELAVL1) binds and stabilizes mRNA"/>
            <pathway-xref db="MetaCyc" id="PWY-7280" name="ternatin C3 biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-5673000" name="RAF activation"/>
            <pathway-xref db="Reactome" id="R-HSA-9665249" name="Resistance of ERBB2 KD mutants to afatinib"/>
            <pathway-xref db="Reactome" id="R-MMU-937072" name="TRAF6-mediated induction of TAK1 complex within TLR4 complex"/>
            <pathway-xref db="Reactome" id="R-MMU-1679131" name="Trafficking and processing of endosomal TLR"/>
            <pathway-xref db="MetaCyc" id="PWY-6027" name="capsiconiate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-GGA-2022857" name="Keratan sulfate degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7954" name="tabtoxinine-beta-lactam biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-6807004" name="Negative regulation of MET activity"/>
            <pathway-xref db="Reactome" id="R-MMU-5673000" name="RAF activation"/>
            <pathway-xref db="Reactome" id="R-MMU-375281" name="Hormone ligand-binding receptors"/>
            <pathway-xref db="Reactome" id="R-HSA-445989" name="TAK1 activates NFkB by phosphorylation and activation of IKKs complex"/>
            <pathway-xref db="Reactome" id="R-MMU-8873719" name="RAB geranylgeranylation"/>
            <pathway-xref db="MetaCyc" id="PWY-6998" name="CDP-D-arabitol biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-450321" name="JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1"/>
            <pathway-xref db="Reactome" id="R-HSA-9010553" name="Regulation of expression of SLITs and ROBOs"/>
            <pathway-xref db="Reactome" id="R-DRE-380284" name="Loss of proteins required for interphase microtubule organization from the centrosome"/>
            <pathway-xref db="Reactome" id="R-DDI-3295583" name="TRP channels"/>
            <pathway-xref db="MetaCyc" id="PWY-7352" name="daunorubicin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-214862" name="Activated PLL kinase is autophosphorylated in the TL receptor 'signalling complex'"/>
            <pathway-xref db="Reactome" id="R-MMU-9034793" name="Activated NTRK3 signals through PLCG1"/>
            <pathway-xref db="Reactome" id="R-HSA-2022857" name="Keratan sulfate degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-936440" name="Negative regulators of DDX58/IFIH1 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-9696270" name="RND2 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-2681" name="trans-zeatin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-159230" name="Transport of the SLBP Dependant Mature mRNA"/>
            <pathway-xref db="Reactome" id="R-HSA-9665233" name="Resistance of ERBB2 KD mutants to trastuzumab"/>
            <pathway-xref db="Reactome" id="R-MMU-159230" name="Transport of the SLBP Dependant Mature mRNA"/>
            <pathway-xref db="Reactome" id="R-HSA-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-RNO-430116" name="GP1b-IX-V activation signalling"/>
            <pathway-xref db="Reactome" id="R-HSA-936440" name="Negative regulators of DDX58/IFIH1 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-8116" name="ochratoxin A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-975110" name="TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-975155" name="MyD88 dependent cascade initiated on endosome"/>
            <pathway-xref db="Reactome" id="R-BTA-1474228" name="Degradation of the extracellular matrix"/>
            <pathway-xref db="Reactome" id="R-HSA-5602498" name="MyD88 deficiency (TLR2/4)"/>
            <pathway-xref db="Reactome" id="R-SPO-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="MetaCyc" id="PWY-6373" name="acrylate degradation I"/>
            <pathway-xref db="Reactome" id="R-DRE-9696270" name="RND2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-5602415" name="UNC93B1 deficiency - HSE"/>
            <pathway-xref db="Reactome" id="R-MMU-8939902" name="Regulation of RUNX2 expression and activity"/>
            <pathway-xref db="Reactome" id="R-HSA-2500257" name="Resolution of Sister Chromatid Cohesion"/>
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            <pathway-xref db="Reactome" id="R-MMU-9013404" name="RAC2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-9673221" name="Defective F9 activation"/>
            <pathway-xref db="MetaCyc" id="PWY-7461" name="hydroxycinnamate sugar acid ester biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SCE-9696270" name="RND2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-193634" name="Axonal growth inhibition (RHOA activation)"/>
            <pathway-xref db="Reactome" id="R-HSA-168179" name="Toll Like Receptor TLR1:TLR2 Cascade"/>
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            <pathway-xref db="MetaCyc" id="PWY-7653" name="griseofulvin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DDI-381676" name="Glucagon-like Peptide-1 (GLP1) regulates insulin secretion"/>
            <pathway-xref db="MetaCyc" id="PWY-8012" name="mupirocin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9013424" name="RHOV GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-9687136" name="Aberrant regulation of mitotic exit in cancer due to RB1 defects"/>
            <pathway-xref db="MetaCyc" id="PWY-4801" name="aloesone biosynthesis I"/>
            <pathway-xref db="Reactome" id="R-HSA-167021" name="PLC-gamma1 signalling"/>
            <pathway-xref db="MetaCyc" id="PWY-7171" name="flavonol acylglucoside biosynthesis II - isorhamnetin derivatives"/>
            <pathway-xref db="Reactome" id="R-SCE-9615933" name="Postmitotic nuclear pore complex (NPC) reformation"/>
            <pathway-xref db="Reactome" id="R-RNO-187042" name="TRKA activation by NGF"/>
            <pathway-xref db="Reactome" id="R-HSA-5620916" name="VxPx cargo-targeting to cilium"/>
            <pathway-xref db="Reactome" id="R-CFA-2022870" name="Chondroitin sulfate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-1461957" name="Beta defensins"/>
            <pathway-xref db="MetaCyc" id="PWY-7679" name="anthocyanidin acylglucoside and acylsambubioside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9652282" name="Drug-mediated inhibition of ERBB2 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-6803205" name="TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain"/>
            <pathway-xref db="MetaCyc" id="PWY-6958" name="icosapentaenoate biosynthesis I (lower eukaryotes)"/>
            <pathway-xref db="Reactome" id="R-HSA-5602410" name="TLR3 deficiency - HSE"/>
            <pathway-xref db="Reactome" id="R-XTR-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-DDI-1632852" name="Macroautophagy"/>
            <pathway-xref db="Reactome" id="R-HSA-373752" name="Netrin-1 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-166020" name="Transfer of LPS from LBP carrier to CD14"/>
            <pathway-xref db="Reactome" id="R-DRE-380320" name="Recruitment of NuMA to mitotic centrosomes"/>
            <pathway-xref db="MetaCyc" id="PWY-5475" name="pentagalloylglucose biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-381426" name="Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"/>
            <pathway-xref db="Reactome" id="R-DRE-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7688" name="dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9634285" name="Constitutive Signaling by Overexpressed ERBB2"/>
            <pathway-xref db="Reactome" id="R-MMU-5223345" name="Miscellaneous transport and binding events"/>
            <pathway-xref db="MetaCyc" id="PWY-7713" name="nivalenol biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-MMU-141444" name="Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"/>
            <pathway-xref db="MetaCyc" id="PWY-7669" name="equisetin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-380259" name="Loss of Nlp from mitotic centrosomes"/>
            <pathway-xref db="Reactome" id="R-SCE-3108232" name="SUMO E3 ligases SUMOylate target proteins"/>
            <pathway-xref db="Reactome" id="R-HSA-8985586" name="SLIT2:ROBO1 increases RHOA activity"/>
            <pathway-xref db="MetaCyc" id="PWY-7470" name="phosphatidylcholine biosynthesis VII"/>
            <pathway-xref db="Reactome" id="R-MMU-5654687" name="Downstream signaling of activated FGFR1"/>
            <pathway-xref db="Reactome" id="R-DDI-5675482" name="Regulation of necroptotic cell death"/>
            <pathway-xref db="MetaCyc" id="PWY-6944" name="androstenedione degradation I (aerobic)"/>
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            <pathway-xref db="Reactome" id="R-SPO-199418" name="Negative regulation of the PI3K/AKT network"/>
            <pathway-xref db="MetaCyc" id="PWY-7904" name="tRNA-uridine 2-thiolation (thermophilic bacteria)"/>
            <pathway-xref db="Reactome" id="R-DME-214869" name="Phosphorylated CACT, DL and DIF homodimers dissociate from the TL receptor 'signalling complex'"/>
            <pathway-xref db="MetaCyc" id="PWY-7884" name="lipoprotein posttranslational modification"/>
            <pathway-xref db="MetaCyc" id="PWY-7659" name="viridicatumtoxin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-84" name="resveratrol biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-140837" name="Intrinsic Pathway of Fibrin Clot Formation"/>
            <pathway-xref db="MetaCyc" id="PWY-7250" name="[2Fe-2S] iron-sulfur cluster biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6682" name="dehydrophos biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-2243919" name="Crosslinking of collagen fibrils"/>
            <pathway-xref db="Reactome" id="R-HSA-168164" name="Toll Like Receptor 3 (TLR3) Cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-166016" name="Toll Like Receptor 4 (TLR4) Cascade"/>
            <pathway-xref db="Reactome" id="R-MMU-445989" name="TAK1 activates NFkB by phosphorylation and activation of IKKs complex"/>
            <pathway-xref db="Reactome" id="R-MMU-163210" name="Formation of ATP by chemiosmotic coupling"/>
            <pathway-xref db="MetaCyc" id="PWY-7728" name="(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)"/>
            <pathway-xref db="MetaCyc" id="PWY-6626" name="cytidine-5'-diphosphate-glycerol biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-140534" name="Caspase activation via Death Receptors in the presence of ligand"/>
            <pathway-xref db="Reactome" id="R-CEL-3108232" name="SUMO E3 ligases SUMOylate target proteins"/>
            <pathway-xref db="Reactome" id="R-DME-159231" name="Transport of Mature mRNA Derived from an Intronless Transcript"/>
            <pathway-xref db="Reactome" id="R-CEL-209968" name="Thyroxine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-438066" name="Unblocking of NMDA receptors, glutamate binding and activation"/>
            <pathway-xref db="MetaCyc" id="PWY-5381" name="NAD salvage (plants)"/>
            <pathway-xref db="MetaCyc" id="PWY-7746" name="mycobacterial sulfolipid biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-187024" name="NGF-independant TRKA activation"/>
            <pathway-xref db="MetaCyc" id="PWY-8151" name="cholesterol degradation to androstenedione III (anaerobic)"/>
            <pathway-xref db="Reactome" id="R-HSA-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-166020" name="Transfer of LPS from LBP carrier to CD14"/>
            <pathway-xref db="MetaCyc" id="PWY-7002" name="4-hydroxyacetophenone degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7053" name="docosahexaenoate biosynthesis I (lower eukaryotes)"/>
            <pathway-xref db="Reactome" id="R-MMU-166016" name="Toll Like Receptor 4 (TLR4) Cascade"/>
            <pathway-xref db="Reactome" id="R-RNO-5654687" name="Downstream signaling of activated FGFR1"/>
            <pathway-xref db="Reactome" id="R-HSA-844456" name="The NLRP3 inflammasome"/>
            <pathway-xref db="Reactome" id="R-HSA-170968" name="Frs2-mediated activation"/>
            <pathway-xref db="Reactome" id="R-MMU-1227986" name="Signaling by ERBB2"/>
            <pathway-xref db="Reactome" id="R-MMU-114608" name="Platelet degranulation"/>
            <pathway-xref db="Reactome" id="R-RNO-159231" name="Transport of Mature mRNA Derived from an Intronless Transcript"/>
            <pathway-xref db="Reactome" id="R-HSA-450302" name="activated TAK1 mediates p38 MAPK activation"/>
            <pathway-xref db="Reactome" id="R-MMU-174178" name="APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1"/>
            <pathway-xref db="Reactome" id="R-BTA-2022854" name="Keratan sulfate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8243" name="colanic acid (Escherichia coli K12) biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-844456" name="The NLRP3 inflammasome"/>
            <pathway-xref db="Reactome" id="R-HSA-198203" name="PI3K/AKT activation"/>
            <pathway-xref db="Reactome" id="R-HSA-114608" name="Platelet degranulation"/>
            <pathway-xref db="Reactome" id="R-MMU-199418" name="Negative regulation of the PI3K/AKT network"/>
            <pathway-xref db="MetaCyc" id="PWY-7816" name="poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)"/>
            <pathway-xref db="Reactome" id="R-HSA-428540" name="Activation of RAC1"/>
            <pathway-xref db="MetaCyc" id="PWY-8045" name="cylindrospermopsin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-HSA-168142" name="Toll Like Receptor 10 (TLR10) Cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-198745" name="Signalling to STAT3"/>
            <pathway-xref db="Reactome" id="R-MMU-450302" name="activated TAK1 mediates p38 MAPK activation"/>
            <pathway-xref db="MetaCyc" id="PWY-7719" name="CMP-diacetamido-8-epilegionaminic acid biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7690" name="holomycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-BTA-5223345" name="Miscellaneous transport and binding events"/>
            <pathway-xref db="Reactome" id="R-HSA-9648025" name="EML4 and NUDC in mitotic spindle formation"/>
            <pathway-xref db="MetaCyc" id="PWY-5660" name="taxol biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-2024101" name="CS/DS degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-430116" name="GP1b-IX-V activation signalling"/>
            <pathway-xref db="Reactome" id="R-HSA-5689901" name="Metalloprotease DUBs"/>
            <pathway-xref db="MetaCyc" id="PWY-7696" name="citreoisocoumarin and bikisocoumarin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7342" name="superpathway of nicotine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-68949" name="Orc1 removal from chromatin"/>
            <pathway-xref db="Reactome" id="R-HSA-9013026" name="RHOB GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-BTA-3000178" name="ECM proteoglycans"/>
            <pathway-xref db="Reactome" id="R-HSA-937072" name="TRAF6-mediated induction of TAK1 complex within TLR4 complex"/>
            <pathway-xref db="Reactome" id="R-HSA-187706" name="Signalling to p38 via RIT and RIN"/>
            <pathway-xref db="Reactome" id="R-CEL-8951664" name="Neddylation"/>
            <pathway-xref db="Reactome" id="R-DDI-1660499" name="Synthesis of PIPs at the plasma membrane"/>
            <pathway-xref db="MetaCyc" id="PWY-7592" name="arachidonate biosynthesis III (6-desaturase, mammals)"/>
            <pathway-xref db="Reactome" id="R-HSA-8849932" name="Synaptic adhesion-like molecules"/>
            <pathway-xref db="Reactome" id="R-HSA-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-HSA-9660821" name="ADORA2B mediated anti-inflammatory cytokines production"/>
            <pathway-xref db="MetaCyc" id="PWY-8152" name="androstenedione degradation II (anaerobic)"/>
            <pathway-xref db="MetaCyc" id="PWY-361" name="phenylpropanoid biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9664565" name="Signaling by ERBB2 KD Mutants"/>
            <pathway-xref db="Reactome" id="R-HSA-1971475" name="A tetrasaccharide linker sequence is required for GAG synthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-5617472" name="Activation of anterior HOX genes in hindbrain development during early embryogenesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5984" name="rifamycin B biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6442" name="spermidine hydroxycinnamic acid conjugates biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SPO-159227" name="Transport of the SLBP independent Mature mRNA"/>
            <pathway-xref db="MetaCyc" id="PWY-7530" name="Escherichia coli serotype O:104 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9609736" name="Assembly and cell surface presentation of NMDA receptors"/>
            <pathway-xref db="Reactome" id="R-RNO-450520" name="HuR (ELAVL1) binds and stabilizes mRNA"/>
            <pathway-xref db="Reactome" id="R-MMU-5689896" name="Ovarian tumor domain proteases"/>
            <pathway-xref db="Reactome" id="R-MMU-163125" name="Post-translational modification: synthesis of GPI-anchored proteins"/>
            <pathway-xref db="MetaCyc" id="PWY-6673" name="caffeoylglucarate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9707564" name="Cytoprotection by HMOX1"/>
            <pathway-xref db="MetaCyc" id="PWY-6799" name="fatty acid biosynthesis initiation (plant mitochondria)"/>
            <pathway-xref db="Reactome" id="R-RNO-2022870" name="Chondroitin sulfate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-389977" name="Post-chaperonin tubulin folding pathway"/>
            <pathway-xref db="Reactome" id="R-HSA-9603381" name="Activated NTRK3 signals through PI3K"/>
            <pathway-xref db="Reactome" id="R-HSA-9034013" name="NTF3 activates NTRK3 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-6804115" name="TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"/>
            <pathway-xref db="MetaCyc" id="PWY-7706" name="dapdiamides biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7318" name="dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7986" name="anguibactin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9696270" name="RND2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-3214842" name="HDMs demethylate histones"/>
            <pathway-xref db="Reactome" id="R-SCE-163210" name="Formation of ATP by chemiosmotic coupling"/>
            <pathway-xref db="Reactome" id="R-DME-214874" name="PLL kinase binds to TUB in the TL receptor 'signalling complex'"/>
            <pathway-xref db="Reactome" id="R-HSA-9696264" name="RND3 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-9028731" name="Activated NTRK2 signals through FRS2 and FRS3"/>
            <pathway-xref db="MetaCyc" id="PWY-7407" name="aurachin A, B, C and D biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-141444" name="Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"/>
            <pathway-xref db="Reactome" id="R-HSA-9013149" name="RAC1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-9615933" name="Postmitotic nuclear pore complex (NPC) reformation"/>
            <pathway-xref db="Reactome" id="R-HSA-9013423" name="RAC3 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-6310" name="aloesone biosynthesis II"/>
            <pathway-xref db="Reactome" id="R-SCE-199418" name="Negative regulation of the PI3K/AKT network"/>
            <pathway-xref db="Reactome" id="R-HSA-428542" name="Regulation of commissural axon pathfinding by SLIT and ROBO"/>
            <pathway-xref db="Reactome" id="R-DME-4615885" name="SUMOylation of DNA replication proteins"/>
            <pathway-xref db="MetaCyc" id="PWY-7815" name="poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)"/>
            <pathway-xref db="Reactome" id="R-RNO-159236" name="Transport of Mature mRNA derived from an Intron-Containing Transcript"/>
            <pathway-xref db="MetaCyc" id="PWY-5794" name="malonate degradation I (biotin-independent)"/>
            <pathway-xref db="Reactome" id="R-HSA-9020702" name="Interleukin-1 signaling"/>
            <pathway-xref db="Reactome" id="R-DRE-380259" name="Loss of Nlp from mitotic centrosomes"/>
            <pathway-xref db="MetaCyc" id="PWY-7712" name="deoxynivalenol biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-193634" name="Axonal growth inhibition (RHOA activation)"/>
            <pathway-xref db="Reactome" id="R-MMU-187577" name="SCF(Skp2)-mediated degradation of p27/p21"/>
            <pathway-xref db="Reactome" id="R-MMU-6794361" name="Neurexins and neuroligins"/>
            <pathway-xref db="MetaCyc" id="PWY-5466" name="matairesinol biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-390522" name="Striated Muscle Contraction"/>
            <pathway-xref db="MetaCyc" id="PWY-5461" name="betanidin degradation"/>
            <pathway-xref db="Reactome" id="R-SPO-163210" name="Formation of ATP by chemiosmotic coupling"/>
            <pathway-xref db="Reactome" id="R-HSA-844623" name="The IPAF inflammasome"/>
            <pathway-xref db="Reactome" id="R-SCE-5223345" name="Miscellaneous transport and binding events"/>
            <pathway-xref db="Reactome" id="R-HSA-6803207" name="TP53 Regulates Transcription of Caspase Activators and Caspases"/>
            <pathway-xref db="Reactome" id="R-HSA-4615885" name="SUMOylation of DNA replication proteins"/>
            <pathway-xref db="MetaCyc" id="PWY-7382" name="lipoate biosynthesis and incorporation IV (yeast)"/>
            <pathway-xref db="MetaCyc" id="PWY-8035" name="streptovaricin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-6803207" name="TP53 Regulates Transcription of Caspase Activators and Caspases"/>
            <pathway-xref db="MetaCyc" id="PWY-7583" name="arachidonate biosynthesis II (bacteria)"/>
            <pathway-xref db="MetaCyc" id="PWY-7460" name="2-O-acetyl-3-O-trans-coutarate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-6807004" name="Negative regulation of MET activity"/>
            <pathway-xref db="MetaCyc" id="PWY-7888" name="tRNA-uridine 2-thiolation (cytoplasmic)"/>
            <pathway-xref db="Reactome" id="R-HSA-9032759" name="NTRK2 activates RAC1"/>
            <pathway-xref db="Reactome" id="R-HSA-877300" name="Interferon gamma signaling"/>
            <pathway-xref db="Reactome" id="R-DDI-9013149" name="RAC1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DME-9013406" name="RHOQ GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-8863795" name="Downregulation of ERBB2 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-8051" name="anandamide biosynthesis I"/>
            <pathway-xref db="Reactome" id="R-HSA-75892" name="Platelet Adhesion to exposed collagen"/>
            <pathway-xref db="Reactome" id="R-MMU-4615885" name="SUMOylation of DNA replication proteins"/>
            <pathway-xref db="Reactome" id="R-MMU-8857538" name="PTK6 promotes HIF1A stabilization"/>
            <pathway-xref db="Reactome" id="R-HSA-9620244" name="Long-term potentiation"/>
            <pathway-xref db="Reactome" id="R-RNO-444821" name="Relaxin receptors"/>
            <pathway-xref db="Reactome" id="R-HSA-400253" name="Circadian Clock"/>
            <pathway-xref db="Reactome" id="R-HSA-3656225" name="Defective CHST6 causes MCDC1"/>
            <pathway-xref db="Reactome" id="R-SPO-9696270" name="RND2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-8875360" name="InlB-mediated entry of Listeria monocytogenes into host cell"/>
            <pathway-xref db="Reactome" id="R-HSA-1606341" name="IRF3 mediated activation of type 1 IFN"/>
            <pathway-xref db="Reactome" id="R-SSC-375281" name="Hormone ligand-binding receptors"/>
            <pathway-xref db="Reactome" id="R-HSA-8863795" name="Downregulation of ERBB2 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-8231" name="Escherichia coli serotype O:127 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-167044" name="Signalling to RAS"/>
            <pathway-xref db="Reactome" id="R-MMU-8949613" name="Cristae formation"/>
            <pathway-xref db="Reactome" id="R-RNO-438066" name="Unblocking of NMDA receptors, glutamate binding and activation"/>
            <pathway-xref db="Reactome" id="R-MMU-9013408" name="RHOG GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-SPO-9615933" name="Postmitotic nuclear pore complex (NPC) reformation"/>
            <pathway-xref db="Reactome" id="R-MMU-6807004" name="Negative regulation of MET activity"/>
            <pathway-xref db="Reactome" id="R-HSA-9603505" name="NTRK3 as a dependence receptor"/>
            <pathway-xref db="Reactome" id="R-MMU-187042" name="TRKA activation by NGF"/>
            <pathway-xref db="Reactome" id="R-HSA-8857538" name="PTK6 promotes HIF1A stabilization"/>
            <pathway-xref db="Reactome" id="R-HSA-3595172" name="Defective CHST3 causes SEDCJD"/>
            <pathway-xref db="Reactome" id="R-RNO-8849932" name="Synaptic adhesion-like molecules"/>
            <pathway-xref db="Reactome" id="R-HSA-9665251" name="Resistance of ERBB2 KD mutants to lapatinib"/>
            <pathway-xref db="MetaCyc" id="PWY-81" name="toluene degradation to benzoyl-CoA (anaerobic)"/>
            <pathway-xref db="MetaCyc" id="PWY-7532" name="acetylaszonalenin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5835" name="geranyl acetate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6036" name="cardenolide glucosides biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-1839117" name="Signaling by cytosolic FGFR1 fusion mutants"/>
            <pathway-xref db="Reactome" id="R-MMU-2022870" name="Chondroitin sulfate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CFA-3000178" name="ECM proteoglycans"/>
            <pathway-xref db="Reactome" id="R-HSA-9013418" name="RHOBTB2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-9665348" name="Signaling by ERBB2 ECD mutants"/>
            <pathway-xref db="MetaCyc" id="PWY-7671" name="saframycin A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-5689901" name="Metalloprotease DUBs"/>
            <pathway-xref db="Reactome" id="R-HSA-9013408" name="RHOG GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-7693" name="guadinomine B biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-936964" name="Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon"/>
            <pathway-xref db="Reactome" id="R-HSA-9665246" name="Resistance of ERBB2 KD mutants to neratinib"/>
            <pathway-xref db="Reactome" id="R-MMU-9013418" name="RHOBTB2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-844455" name="The NLRP1 inflammasome"/>
            <pathway-xref db="MetaCyc" id="PWY-8166" name="emodin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-375281" name="Hormone ligand-binding receptors"/>
            <pathway-xref db="Reactome" id="R-HSA-381426" name="Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"/>
            <pathway-xref db="Reactome" id="R-BTA-2022923" name="Dermatan sulfate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-72163" name="mRNA Splicing - Major Pathway"/>
            <pathway-xref db="MetaCyc" id="PWY-7989" name="acinetoferrin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7677" name="rosamicin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7261" name="anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)"/>
            <pathway-xref db="Reactome" id="R-HSA-9032500" name="Activated NTRK2 signals through FYN"/>
            <pathway-xref db="Reactome" id="R-MMU-69231" name="Cyclin D associated events in G1"/>
            <pathway-xref db="Reactome" id="R-HSA-9665250" name="Resistance of ERBB2 KD mutants to AEE788"/>
            <pathway-xref db="MetaCyc" id="PWY-7702" name="sch210971 and sch210972 biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-5682910" name="LGI-ADAM interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-9028335" name="Activated NTRK2 signals through PI3K"/>
            <pathway-xref db="Reactome" id="R-CFA-109704" name="PI3K Cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-9013148" name="CDC42 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-6558" name="heparan sulfate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-168176" name="Toll Like Receptor 5 (TLR5) Cascade"/>
            <pathway-xref db="Reactome" id="R-MMU-75892" name="Platelet Adhesion to exposed collagen"/>
            <pathway-xref db="Reactome" id="R-HSA-8950505" name="Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"/>
            <pathway-xref db="MetaCyc" id="PWY-6056" name="dimethylsulfoniopropanoate degradation II (cleavage)"/>
            <pathway-xref db="Reactome" id="R-HSA-168928" name="DDX58/IFIH1-mediated induction of interferon-alpha/beta"/>
            <pathway-xref db="Reactome" id="R-HSA-166058" name="MyD88:MAL(TIRAP) cascade initiated on plasma membrane"/>
            <pathway-xref db="MetaCyc" id="PWY-7452" name="cyanidin dimalonylglucoside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-168138" name="Toll Like Receptor 9 (TLR9) Cascade"/>
            <pathway-xref db="MetaCyc" id="PWY-8038" name="naphthomycin biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-MMU-9013148" name="CDC42 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-7458" name="violdelphin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7672" name="fusaric acid biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7529" name="CMP-N-acetyl-7-O-acetylneuraminate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-8985801" name="Regulation of cortical dendrite branching"/>
            <pathway-xref db="Reactome" id="R-HSA-9662360" name="Sensory processing of sound by inner hair cells of the cochlea"/>
            <pathway-xref db="Reactome" id="R-CEL-376176" name="Signaling by ROBO receptors"/>
            <pathway-xref db="Reactome" id="R-HSA-4641263" name="Regulation of FZD by ubiquitination"/>
            <pathway-xref db="MetaCyc" id="PWY-5679" name="clavulanate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9013409" name="RHOJ GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-7511" name="protein ubiquitination"/>
            <pathway-xref db="MetaCyc" id="PWY-8075" name="(Kdo)2-lipid A biosynthesis (P. putida)"/>
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            <pathway-xref db="Reactome" id="R-MMU-450520" name="HuR (ELAVL1) binds and stabilizes mRNA"/>
            <pathway-xref db="Reactome" id="R-HSA-8949613" name="Cristae formation"/>
            <pathway-xref db="Reactome" id="R-DME-159230" name="Transport of the SLBP Dependant Mature mRNA"/>
            <pathway-xref db="MetaCyc" id="PWY-6289" name="petrobactin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-428890" name="Role of ABL in ROBO-SLIT signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-4641263" name="Regulation of FZD by ubiquitination"/>
            <pathway-xref db="Reactome" id="R-MMU-9032759" name="NTRK2 activates RAC1"/>
            <pathway-xref db="Reactome" id="R-RNO-936440" name="Negative regulators of DDX58/IFIH1 signaling"/>
            <pathway-xref db="Reactome" id="R-DDI-1169092" name="Activation of RAS in B cells"/>
            <pathway-xref db="Reactome" id="R-RNO-163125" name="Post-translational modification: synthesis of GPI-anchored proteins"/>
            <pathway-xref db="Reactome" id="R-MMU-3000178" name="ECM proteoglycans"/>
            <pathway-xref db="Reactome" id="R-RNO-9034793" name="Activated NTRK3 signals through PLCG1"/>
            <pathway-xref db="MetaCyc" id="PWY-7265" name="lampranthin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-198203" name="PI3K/AKT activation"/>
            <pathway-xref db="Reactome" id="R-HSA-9013406" name="RHOQ GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-7818" name="type IV lipoteichoic acid biosynthesis (S. pneumoniae)"/>
            <pathway-xref db="Reactome" id="R-GGA-517856" name="TLR2 subfamily cascade"/>
            <pathway-xref db="MetaCyc" id="PWY-7624" name="nystatin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6397" name="mycolyl-arabinogalactan-peptidoglycan complex biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-446388" name="Regulation of cytoskeletal remodeling and cell spreading by IPP complex components"/>
            <pathway-xref db="MetaCyc" id="PWY-7601" name="arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)"/>
            <pathway-xref db="MetaCyc" id="PWY-8249" name="xanthommatin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-2467813" name="Separation of Sister Chromatids"/>
            <pathway-xref db="Reactome" id="R-DRE-8854050" name="FBXL7 down-regulates AURKA during mitotic entry and in early mitosis"/>
            <pathway-xref db="Reactome" id="R-RNO-8951664" name="Neddylation"/>
            <pathway-xref db="Reactome" id="R-DME-214842" name="DL and DIF homodimers bind to TUB and phosphorylated PLL in the TL receptor 'signalling complex'"/>
            <pathway-xref db="Reactome" id="R-HSA-2467813" name="Separation of Sister Chromatids"/>
            <pathway-xref db="Reactome" id="R-MMU-445355" name="Smooth Muscle Contraction"/>
            <pathway-xref db="Reactome" id="R-HSA-8936459" name="RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"/>
            <pathway-xref db="MetaCyc" id="PWY-7983" name="pseudomonine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DDI-202670" name="ERKs are inactivated"/>
            <pathway-xref db="Reactome" id="R-MMU-388844" name="Receptor-type tyrosine-protein phosphatases"/>
            <pathway-xref db="MetaCyc" id="PWY-5400" name="amaranthin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-8854518" name="AURKA Activation by TPX2"/>
            <pathway-xref db="Reactome" id="R-MMU-977606" name="Regulation of Complement cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-168181" name="Toll Like Receptor 7/8 (TLR7/8) Cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-9026527" name="Activated NTRK2 signals through PLCG1"/>
            <pathway-xref db="Reactome" id="R-MMU-170968" name="Frs2-mediated activation"/>
            <pathway-xref db="MetaCyc" id="PWY-6322" name="phosphinothricin tripeptide biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-69231" name="Cyclin D associated events in G1"/>
            <pathway-xref db="MetaCyc" id="PWY-5710" name="capsaicin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-DRE-9696264" name="RND3 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-5437" name="L-threonine degradation I"/>
            <pathway-xref db="MetaCyc" id="PWY-7474" name="avenacin A-2 biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9034015" name="Signaling by NTRK3 (TRKC)"/>
            <pathway-xref db="Reactome" id="R-SCE-8949613" name="Cristae formation"/>
            <pathway-xref db="Reactome" id="R-MMU-2562578" name="TRIF-mediated programmed cell death"/>
            <pathway-xref db="Reactome" id="R-HSA-2562578" name="TRIF-mediated programmed cell death"/>
            <pathway-xref db="Reactome" id="R-DDI-5621575" name="CD209 (DC-SIGN) signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-844455" name="The NLRP1 inflammasome"/>
            <pathway-xref db="Reactome" id="R-DME-376176" name="Signaling by ROBO receptors"/>
            <pathway-xref db="Reactome" id="R-MMU-159227" name="Transport of the SLBP independent Mature mRNA"/>
            <pathway-xref db="Reactome" id="R-MMU-159236" name="Transport of Mature mRNA derived from an Intron-Containing Transcript"/>
            <pathway-xref db="MetaCyc" id="PWY-7172" name="flavonol acylglucoside biosynthesis III - quercetin derivatives"/>
            <pathway-xref db="MetaCyc" id="PWY-6314" name="plumbagin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-174178" name="APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1"/>
            <pathway-xref db="Reactome" id="R-HSA-376176" name="Signaling by ROBO receptors"/>
            <pathway-xref db="Reactome" id="R-GGA-451514" name="MyD88:TIRAP-dependent cascade initiated on plasma membrane"/>
            <pathway-xref db="MetaCyc" id="PWY-6032" name="digitoxigenin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CFA-418555" name="G alpha (s) signalling events"/>
            <pathway-xref db="Reactome" id="R-DRE-8951664" name="Neddylation"/>
            <pathway-xref db="MetaCyc" id="PWY-7473" name="avenacin A-1 biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-6803207" name="TP53 Regulates Transcription of Caspase Activators and Caspases"/>
            <pathway-xref db="Reactome" id="R-GGA-388844" name="Receptor-type tyrosine-protein phosphatases"/>
            <pathway-xref db="Reactome" id="R-HSA-8854518" name="AURKA Activation by TPX2"/>
            <pathway-xref db="MetaCyc" id="PWY-7716" name="penicillin G and penicillin V biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DDI-1483248" name="Synthesis of PIPs at the ER membrane"/>
            <pathway-xref db="MetaCyc" id="PWY-6190" name="2,4-dichlorotoluene degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7475" name="des-methyl avenacin A-1 biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7045" name="mithramycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-9034013" name="NTF3 activates NTRK3 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-9013106" name="RHOC GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-216083" name="Integrin cell surface interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-2022923" name="Dermatan sulfate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-8941413" name="Events associated with phagocytolytic activity of PMN cells"/>
            <pathway-xref db="Reactome" id="R-DME-159236" name="Transport of Mature mRNA derived from an Intron-Containing Transcript"/>
            <pathway-xref db="Reactome" id="R-DDI-193648" name="NRAGE signals death through JNK"/>
            <pathway-xref db="Reactome" id="R-GGA-2022854" name="Keratan sulfate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-BTA-1971475" name="A tetrasaccharide linker sequence is required for GAG synthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-3656244" name="Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)"/>
            <pathway-xref db="MetaCyc" id="PWY-5473" name="hydroxycinnamic acid serotonin amides biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-109704" name="PI3K Cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-3134975" name="Regulation of innate immune responses to cytosolic DNA"/>
            <pathway-xref db="Reactome" id="R-HSA-159231" name="Transport of Mature mRNA Derived from an Intronless Transcript"/>
            <pathway-xref db="Reactome" id="R-HSA-3270619" name="IRF3-mediated induction of type I IFN"/>
            <pathway-xref db="Reactome" id="R-DDI-354192" name="Integrin signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-975871" name="MyD88 cascade initiated on plasma membrane"/>
            <pathway-xref db="Reactome" id="R-MMU-3134975" name="Regulation of innate immune responses to cytosolic DNA"/>
            <pathway-xref db="MetaCyc" id="PWY-6378" name="putrebactin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DRE-8849932" name="Synaptic adhesion-like molecules"/>
            <pathway-xref db="Reactome" id="R-MMU-166020" name="Transfer of LPS from LBP carrier to CD14"/>
            <pathway-xref db="Reactome" id="R-DRE-380270" name="Recruitment of mitotic centrosome proteins and complexes"/>
            <pathway-xref db="Reactome" id="R-HSA-8955332" name="Carboxyterminal post-translational modifications of tubulin"/>
            <pathway-xref db="Reactome" id="R-HSA-163125" name="Post-translational modification: synthesis of GPI-anchored proteins"/>
            <pathway-xref db="Reactome" id="R-HSA-975163" name="IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation"/>
            <pathway-xref db="Reactome" id="R-RNO-9696264" name="RND3 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-7738" name="polyacyltrehalose biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-CFA-168138" name="Toll Like Receptor 9 (TLR9) Cascade"/>
            <pathway-xref db="MetaCyc" id="PWY-6462" name="peptidoglycan cross-bridge biosynthesis III (Enterococcus faecalis)"/>
            <pathway-xref db="Reactome" id="R-RNO-429947" name="Deadenylation of mRNA"/>
            <pathway-xref db="Reactome" id="R-DDI-392517" name="Rap1 signalling"/>
            <pathway-xref db="Reactome" id="R-HSA-2022870" name="Chondroitin sulfate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8058" name="2-deoxy-D-ribose degradation II"/>
            <pathway-xref db="MetaCyc" id="PWY-7577" name="ferrichrome biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7940" name="lauryl-hydroxychlorobactene glucoside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9026519" name="Activated NTRK2 signals through RAS"/>
            <pathway-xref db="Reactome" id="R-MMU-9026527" name="Activated NTRK2 signals through PLCG1"/>
            <pathway-xref db="Reactome" id="R-MMU-380284" name="Loss of proteins required for interphase microtubule organization from the centrosome"/>
            <pathway-xref db="MetaCyc" id="PWY-6039" name="chlorogenic acid biosynthesis I"/>
            <pathway-xref db="Reactome" id="R-SPO-3108232" name="SUMO E3 ligases SUMOylate target proteins"/>
            <pathway-xref db="Reactome" id="R-DME-159227" name="Transport of the SLBP independent Mature mRNA"/>
            <pathway-xref db="Reactome" id="R-DME-388844" name="Receptor-type tyrosine-protein phosphatases"/>
            <pathway-xref db="Reactome" id="R-MMU-9028731" name="Activated NTRK2 signals through FRS2 and FRS3"/>
            <pathway-xref db="MetaCyc" id="PWY-8210" name="pyrrolomycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9028731" name="Activated NTRK2 signals through FRS2 and FRS3"/>
            <pathway-xref db="MetaCyc" id="PWY-5292" name="vindoline, vindorosine and vinblastine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-3270619" name="IRF3-mediated induction of type I IFN"/>
            <pathway-xref db="MetaCyc" id="PWY-7367" name="phosphatidylcholine resynthesis via glycerophosphocholine"/>
            <pathway-xref db="Reactome" id="R-MMU-2022923" name="Dermatan sulfate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7907" name="(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9665737" name="Drug resistance in ERBB2 TMD/JMD mutants"/>
            <pathway-xref db="MetaCyc" id="PWY-7555" name="alpha-cyclopiazonate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-3000178" name="ECM proteoglycans"/>
            <pathway-xref db="Reactome" id="R-HSA-9013106" name="RHOC GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-5673000" name="RAF activation"/>
            <pathway-xref db="MetaCyc" id="PWY-7735" name="echinomycin and triostin A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-2022854" name="Keratan sulfate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SPO-5223345" name="Miscellaneous transport and binding events"/>
            <pathway-xref db="MetaCyc" id="PWY-7621" name="autoinducer CAI-1 biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5994" name="palmitate biosynthesis I (type I fatty acid synthase)"/>
            <pathway-xref db="Reactome" id="R-CEL-159236" name="Transport of Mature mRNA derived from an Intron-Containing Transcript"/>
            <pathway-xref db="Reactome" id="R-RNO-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-8047" name="bryostatin biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-HSA-3560783" name="Defective B4GALT7 causes EDS, progeroid type"/>
            <pathway-xref db="MetaCyc" id="PWY-6948" name="sitosterol degradation to androstenedione"/>
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            <pathway-xref db="Reactome" id="R-CFA-2024101" name="CS/DS degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-5602680" name="MyD88 deficiency (TLR5)"/>
            <pathway-xref db="Reactome" id="R-HSA-375281" name="Hormone ligand-binding receptors"/>
            <pathway-xref db="MetaCyc" id="PWY-8179" name="platensimycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9665245" name="Resistance of ERBB2 KD mutants to tesevatinib"/>
            <pathway-xref db="Reactome" id="R-HSA-9013404" name="RAC2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DRE-450520" name="HuR (ELAVL1) binds and stabilizes mRNA"/>
            <pathway-xref db="Reactome" id="R-XTR-3214842" name="HDMs demethylate histones"/>
            <pathway-xref db="Reactome" id="R-MMU-9010553" name="Regulation of expression of SLITs and ROBOs"/>
            <pathway-xref db="Reactome" id="R-RNO-9026527" name="Activated NTRK2 signals through PLCG1"/>
            <pathway-xref db="Reactome" id="R-RNO-2024101" name="CS/DS degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-8985586" name="SLIT2:ROBO1 increases RHOA activity"/>
            <pathway-xref db="Reactome" id="R-DRE-2022854" name="Keratan sulfate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8133" name="succinoglycan biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-GGA-9028731" name="Activated NTRK2 signals through FRS2 and FRS3"/>
            <pathway-xref db="MetaCyc" id="PWY-7564" name="bacimethrin and bacimethrin pyrophosphate biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-GGA-433822" name="NFkB and MAPK activation mediated by TRAF6"/>
            <pathway-xref db="MetaCyc" id="PWY-8272" name="Escherichia coli serotype O:49 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-9013424" name="RHOV GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-5686938" name="Regulation of TLR by endogenous ligand"/>
            <pathway-xref db="Reactome" id="R-MMU-2022857" name="Keratan sulfate degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-5316" name="nicotine biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-HSA-9665686" name="Signaling by ERBB2 TMD/JMD mutants"/>
            <pathway-xref db="Reactome" id="R-MMU-2500257" name="Resolution of Sister Chromatid Cohesion"/>
            <pathway-xref db="Reactome" id="R-HSA-9034793" name="Activated NTRK3 signals through PLCG1"/>
            <pathway-xref db="Reactome" id="R-CEL-9615933" name="Postmitotic nuclear pore complex (NPC) reformation"/>
            <pathway-xref db="Reactome" id="R-HSA-9013957" name="TLR3-mediated TICAM1-dependent programmed cell death"/>
            <pathway-xref db="MetaCyc" id="PWY-7727" name="docosahexaenoate biosynthesis IV (4-desaturase, mammals)"/>
            <pathway-xref db="Reactome" id="R-HSA-8873719" name="RAB geranylgeranylation"/>
            <pathway-xref db="MetaCyc" id="PWY-6312" name="barbaloin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DDI-5674135" name="MAP2K and MAPK activation"/>
            <pathway-xref db="Reactome" id="R-HSA-216083" name="Integrin cell surface interactions"/>
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            <pathway-xref db="MetaCyc" id="PWY-761" name="rhizobactin 1021 biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-1971475" name="A tetrasaccharide linker sequence is required for GAG synthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7673" name="fusarin C biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-209968" name="Thyroxine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7563" name="bassianin and desmethylbassianin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7214" name="baicalein degradation (hydrogen peroxide detoxification)"/>
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            <pathway-xref db="Reactome" id="R-MMU-9652282" name="Drug-mediated inhibition of ERBB2 signaling"/>
            <pathway-xref db="Reactome" id="R-SSC-168138" name="Toll Like Receptor 9 (TLR9) Cascade"/>
            <pathway-xref db="MetaCyc" id="PWY-6722" name="candicidin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-BTA-2022870" name="Chondroitin sulfate biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-DRE-5620912" name="Anchoring of the basal body to the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-DRE-9013406" name="RHOQ GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-1461957" name="Beta defensins"/>
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            <pathway-xref db="Reactome" id="R-HSA-168188" name="Toll Like Receptor TLR6:TLR2 Cascade"/>
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            <pathway-xref db="Reactome" id="R-HSA-9637628" name="Modulation by Mtb of host immune system"/>
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            <pathway-xref db="MetaCyc" id="PWY-5875" name="staphyloxanthin biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-CEL-9013406" name="RHOQ GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-3595177" name="Defective CHSY1 causes TPBS"/>
            <pathway-xref db="MetaCyc" id="PWY-8157" name="avenanthramide biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-5284" name="shisonin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6848" name="rutin degradation"/>
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            <pathway-xref db="Reactome" id="R-MMU-170984" name="ARMS-mediated activation"/>
            <pathway-xref db="Reactome" id="R-HSA-2243919" name="Crosslinking of collagen fibrils"/>
            <pathway-xref db="Reactome" id="R-DRE-917937" name="Iron uptake and transport"/>
            <pathway-xref db="Reactome" id="R-HSA-3595174" name="Defective CHST14 causes EDS, musculocontractural type"/>
            <pathway-xref db="MetaCyc" id="PWY-6922" name="L-Ndelta-acetylornithine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5846" name="colchicine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5313" name="superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)"/>
            <pathway-xref db="Reactome" id="R-HSA-3656243" name="Defective ST3GAL3 causes MCT12 and EIEE15"/>
            <pathway-xref db="Reactome" id="R-DRE-8854518" name="AURKA Activation by TPX2"/>
            <pathway-xref db="Reactome" id="R-HSA-9660826" name="Purinergic signaling in leishmaniasis infection"/>
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            <pathway-xref db="Reactome" id="R-CFA-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-1236974" name="ER-Phagosome pathway"/>
            <pathway-xref db="Reactome" id="R-DRE-9013148" name="CDC42 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-8117" name="colibactin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-6803207" name="TP53 Regulates Transcription of Caspase Activators and Caspases"/>
            <pathway-xref db="Reactome" id="R-RNO-1474228" name="Degradation of the extracellular matrix"/>
            <pathway-xref db="MetaCyc" id="PWY-7029" name="terminal olefins biosynthesis II"/>
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            <pathway-xref db="Reactome" id="R-SPO-159231" name="Transport of Mature mRNA Derived from an Intronless Transcript"/>
            <pathway-xref db="Reactome" id="R-DDI-5673001" name="RAF/MAP kinase cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-5654687" name="Downstream signaling of activated FGFR1"/>
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            <pathway-xref db="MetaCyc" id="PWY-7694" name="zwittermicin A biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-HSA-1227986" name="Signaling by ERBB2"/>
            <pathway-xref db="Reactome" id="R-MMU-9013406" name="RHOQ GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-SPO-159236" name="Transport of Mature mRNA derived from an Intron-Containing Transcript"/>
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            <pathway-xref db="Reactome" id="R-DRE-3270619" name="IRF3-mediated induction of type I IFN"/>
            <pathway-xref db="MetaCyc" id="PWY-5139" name="pelargonidin conjugates biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-HSA-983231" name="Factors involved in megakaryocyte development and platelet production"/>
            <pathway-xref db="MetaCyc" id="PWY-5477" name="gallotannin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-9648025" name="EML4 and NUDC in mitotic spindle formation"/>
            <pathway-xref db="Reactome" id="R-MMU-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-977606" name="Regulation of Complement cascade"/>
            <pathway-xref db="Reactome" id="R-MMU-8849932" name="Synaptic adhesion-like molecules"/>
            <pathway-xref db="MetaCyc" id="PWY-7599" name="anditomin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-177504" name="Retrograde neurotrophin signalling"/>
            <pathway-xref db="Reactome" id="R-RNO-5673001" name="RAF/MAP kinase cascade"/>
            <pathway-xref db="MetaCyc" id="PWY-7401" name="crotonate fermentation (to acetate and cyclohexane carboxylate)"/>
            <pathway-xref db="Reactome" id="R-DDI-1660516" name="Synthesis of PIPs at the early endosome membrane"/>
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            <pathway-xref db="MetaCyc" id="PWY-6679" name="jadomycin biosynthesis"/>
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        <model-ac>4b8cD01</model-ac>
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            <pathway-xref db="Reactome" id="R-MMU-983231" name="Factors involved in megakaryocyte development and platelet production"/>
            <pathway-xref db="Reactome" id="R-HSA-165054" name="Rev-mediated nuclear export of HIV RNA"/>
            <pathway-xref db="Reactome" id="R-CFA-1474228" name="Degradation of the extracellular matrix"/>
            <pathway-xref db="Reactome" id="R-HSA-390522" name="Striated Muscle Contraction"/>
            <pathway-xref db="Reactome" id="R-RNO-390522" name="Striated Muscle Contraction"/>
            <pathway-xref db="Reactome" id="R-HSA-445355" name="Smooth Muscle Contraction"/>
            <pathway-xref db="Reactome" id="R-CEL-438066" name="Unblocking of NMDA receptors, glutamate binding and activation"/>
            <pathway-xref db="Reactome" id="R-HSA-5686938" name="Regulation of TLR by endogenous ligand"/>
            <pathway-xref db="Reactome" id="R-MMU-168181" name="Toll Like Receptor 7/8 (TLR7/8) Cascade"/>
            <pathway-xref db="Reactome" id="R-RNO-198203" name="PI3K/AKT activation"/>
            <pathway-xref db="Reactome" id="R-HSA-9665244" name="Resistance of ERBB2 KD mutants to sapitinib"/>
            <pathway-xref db="Reactome" id="R-MMU-68949" name="Orc1 removal from chromatin"/>
            <pathway-xref db="Reactome" id="R-HSA-3108232" name="SUMO E3 ligases SUMOylate target proteins"/>
            <pathway-xref db="Reactome" id="R-HSA-8876493" name="InlA-mediated entry of Listeria monocytogenes into host cells"/>
            <pathway-xref db="Reactome" id="R-DRE-6804115" name="TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"/>
            <pathway-xref db="Reactome" id="R-HSA-9660537" name="Signaling by MRAS-complex mutants"/>
            <pathway-xref db="MetaCyc" id="PWY-7887" name="protein SAMPylation and SAMP-mediated thiolation"/>
            <pathway-xref db="Reactome" id="R-HSA-9707616" name="Heme signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-8873719" name="RAB geranylgeranylation"/>
            <pathway-xref db="MetaCyc" id="PWY-6320" name="phaselate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6407" name="yersiniabactin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-5686938" name="Regulation of TLR by endogenous ligand"/>
            <pathway-xref db="Reactome" id="R-GGA-9026527" name="Activated NTRK2 signals through PLCG1"/>
            <pathway-xref db="Reactome" id="R-HSA-140837" name="Intrinsic Pathway of Fibrin Clot Formation"/>
            <pathway-xref db="MetaCyc" id="PWY-5975" name="furaneol and mesifurane biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-214863" name="Adaptor protein complex binds to TL receptor at the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-MMU-5663220" name="RHO GTPases Activate Formins"/>
            <pathway-xref db="MetaCyc" id="PWY-7415" name="tylosin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-5602571" name="TRAF3 deficiency - HSE"/>
            <pathway-xref db="MetaCyc" id="PWY-6946" name="cholesterol degradation to androstenedione II (cholesterol dehydrogenase)"/>
            <pathway-xref db="Reactome" id="R-RNO-844456" name="The NLRP3 inflammasome"/>
            <pathway-xref db="Reactome" id="R-HSA-5663220" name="RHO GTPases Activate Formins"/>
            <pathway-xref db="Reactome" id="R-MMU-76009" name="Platelet Aggregation (Plug Formation)"/>
            <pathway-xref db="Reactome" id="R-MMU-9708530" name="Regulation of BACH1 activity"/>
            <pathway-xref db="Reactome" id="R-HSA-9024909" name="BDNF activates NTRK2 (TRKB) signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-438066" name="Unblocking of NMDA receptors, glutamate binding and activation"/>
            <pathway-xref db="Reactome" id="R-CFA-1971475" name="A tetrasaccharide linker sequence is required for GAG synthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-163210" name="Formation of ATP by chemiosmotic coupling"/>
            <pathway-xref db="Reactome" id="R-MMU-177929" name="Signaling by EGFR"/>
            <pathway-xref db="MetaCyc" id="PWY-1921" name="indole-3-acetate activation II"/>
            <pathway-xref db="Reactome" id="R-DRE-5673000" name="RAF activation"/>
            <pathway-xref db="MetaCyc" id="PWY-8082" name="glycine lipid biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-975138" name="TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation"/>
            <pathway-xref db="MetaCyc" id="PWY-7565" name="aspyridone A biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7769" name="phosalacine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-428890" name="Role of ABL in ROBO-SLIT signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-9603381" name="Activated NTRK3 signals through PI3K"/>
            <pathway-xref db="Reactome" id="R-HSA-199418" name="Negative regulation of the PI3K/AKT network"/>
            <pathway-xref db="Reactome" id="R-HSA-9708530" name="Regulation of BACH1 activity"/>
            <pathway-xref db="MetaCyc" id="PWY-7445" name="luteolin triglucuronide degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-444821" name="Relaxin receptors"/>
            <pathway-xref db="MetaCyc" id="PWY-5903" name="bacillibactin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-6804115" name="TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"/>
            <pathway-xref db="MetaCyc" id="PWY-7689" name="8-O-methylfusarubin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-438066" name="Unblocking of NMDA receptors, glutamate binding and activation"/>
            <pathway-xref db="Reactome" id="R-HSA-9706019" name="RHOBTB3 ATPase cycle"/>
            <pathway-xref db="Reactome" id="R-DME-209442" name="Formation of the trans-membrane 'signalling complex'"/>
            <pathway-xref db="Reactome" id="R-RNO-9013423" name="RAC3 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-170984" name="ARMS-mediated activation"/>
            <pathway-xref db="Reactome" id="R-HSA-1679131" name="Trafficking and processing of endosomal TLR"/>
            <pathway-xref db="MetaCyc" id="PWY-6945" name="cholesterol degradation to androstenedione I (cholesterol oxidase)"/>
            <pathway-xref db="MetaCyc" id="PWY-7464" name="cyanidin 3,7-diglucoside polyacylation biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-8941413" name="Events associated with phagocytolytic activity of PMN cells"/>
            <pathway-xref db="MetaCyc" id="PWY-7726" name="(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)"/>
            <pathway-xref db="Reactome" id="R-SCE-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-MMU-430116" name="GP1b-IX-V activation signalling"/>
            <pathway-xref db="Reactome" id="R-BTA-450520" name="HuR (ELAVL1) binds and stabilizes mRNA"/>
            <pathway-xref db="MetaCyc" id="PWY-7280" name="ternatin C3 biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-5673000" name="RAF activation"/>
            <pathway-xref db="Reactome" id="R-HSA-9665249" name="Resistance of ERBB2 KD mutants to afatinib"/>
            <pathway-xref db="Reactome" id="R-MMU-937072" name="TRAF6-mediated induction of TAK1 complex within TLR4 complex"/>
            <pathway-xref db="Reactome" id="R-MMU-1679131" name="Trafficking and processing of endosomal TLR"/>
            <pathway-xref db="MetaCyc" id="PWY-6027" name="capsiconiate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-GGA-2022857" name="Keratan sulfate degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7954" name="tabtoxinine-beta-lactam biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-6807004" name="Negative regulation of MET activity"/>
            <pathway-xref db="Reactome" id="R-MMU-5673000" name="RAF activation"/>
            <pathway-xref db="Reactome" id="R-MMU-375281" name="Hormone ligand-binding receptors"/>
            <pathway-xref db="Reactome" id="R-HSA-445989" name="TAK1 activates NFkB by phosphorylation and activation of IKKs complex"/>
            <pathway-xref db="Reactome" id="R-MMU-8873719" name="RAB geranylgeranylation"/>
            <pathway-xref db="MetaCyc" id="PWY-6998" name="CDP-D-arabitol biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-450321" name="JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1"/>
            <pathway-xref db="Reactome" id="R-HSA-9010553" name="Regulation of expression of SLITs and ROBOs"/>
            <pathway-xref db="Reactome" id="R-DRE-380284" name="Loss of proteins required for interphase microtubule organization from the centrosome"/>
            <pathway-xref db="Reactome" id="R-DDI-3295583" name="TRP channels"/>
            <pathway-xref db="MetaCyc" id="PWY-7352" name="daunorubicin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-214862" name="Activated PLL kinase is autophosphorylated in the TL receptor 'signalling complex'"/>
            <pathway-xref db="Reactome" id="R-MMU-9034793" name="Activated NTRK3 signals through PLCG1"/>
            <pathway-xref db="Reactome" id="R-HSA-2022857" name="Keratan sulfate degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-936440" name="Negative regulators of DDX58/IFIH1 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-9696270" name="RND2 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-2681" name="trans-zeatin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-159230" name="Transport of the SLBP Dependant Mature mRNA"/>
            <pathway-xref db="Reactome" id="R-HSA-9665233" name="Resistance of ERBB2 KD mutants to trastuzumab"/>
            <pathway-xref db="Reactome" id="R-MMU-159230" name="Transport of the SLBP Dependant Mature mRNA"/>
            <pathway-xref db="Reactome" id="R-HSA-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-RNO-430116" name="GP1b-IX-V activation signalling"/>
            <pathway-xref db="Reactome" id="R-HSA-936440" name="Negative regulators of DDX58/IFIH1 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-8116" name="ochratoxin A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-975110" name="TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-975155" name="MyD88 dependent cascade initiated on endosome"/>
            <pathway-xref db="Reactome" id="R-BTA-1474228" name="Degradation of the extracellular matrix"/>
            <pathway-xref db="Reactome" id="R-HSA-5602498" name="MyD88 deficiency (TLR2/4)"/>
            <pathway-xref db="Reactome" id="R-SPO-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="MetaCyc" id="PWY-6373" name="acrylate degradation I"/>
            <pathway-xref db="Reactome" id="R-DRE-9696270" name="RND2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-5602415" name="UNC93B1 deficiency - HSE"/>
            <pathway-xref db="Reactome" id="R-MMU-8939902" name="Regulation of RUNX2 expression and activity"/>
            <pathway-xref db="Reactome" id="R-HSA-2500257" name="Resolution of Sister Chromatid Cohesion"/>
            <pathway-xref db="Reactome" id="R-HSA-9032845" name="Activated NTRK2 signals through CDK5"/>
            <pathway-xref db="Reactome" id="R-MMU-9013404" name="RAC2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-9673221" name="Defective F9 activation"/>
            <pathway-xref db="MetaCyc" id="PWY-7461" name="hydroxycinnamate sugar acid ester biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SCE-9696270" name="RND2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-193634" name="Axonal growth inhibition (RHOA activation)"/>
            <pathway-xref db="Reactome" id="R-HSA-168179" name="Toll Like Receptor TLR1:TLR2 Cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-450321" name="JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1"/>
            <pathway-xref db="MetaCyc" id="PWY-7653" name="griseofulvin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DDI-381676" name="Glucagon-like Peptide-1 (GLP1) regulates insulin secretion"/>
            <pathway-xref db="MetaCyc" id="PWY-8012" name="mupirocin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9013424" name="RHOV GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-9687136" name="Aberrant regulation of mitotic exit in cancer due to RB1 defects"/>
            <pathway-xref db="MetaCyc" id="PWY-4801" name="aloesone biosynthesis I"/>
            <pathway-xref db="Reactome" id="R-HSA-167021" name="PLC-gamma1 signalling"/>
            <pathway-xref db="MetaCyc" id="PWY-7171" name="flavonol acylglucoside biosynthesis II - isorhamnetin derivatives"/>
            <pathway-xref db="Reactome" id="R-SCE-9615933" name="Postmitotic nuclear pore complex (NPC) reformation"/>
            <pathway-xref db="Reactome" id="R-RNO-187042" name="TRKA activation by NGF"/>
            <pathway-xref db="Reactome" id="R-HSA-5620916" name="VxPx cargo-targeting to cilium"/>
            <pathway-xref db="Reactome" id="R-CFA-2022870" name="Chondroitin sulfate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-1461957" name="Beta defensins"/>
            <pathway-xref db="MetaCyc" id="PWY-7679" name="anthocyanidin acylglucoside and acylsambubioside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9652282" name="Drug-mediated inhibition of ERBB2 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-6803205" name="TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain"/>
            <pathway-xref db="MetaCyc" id="PWY-6958" name="icosapentaenoate biosynthesis I (lower eukaryotes)"/>
            <pathway-xref db="Reactome" id="R-HSA-5602410" name="TLR3 deficiency - HSE"/>
            <pathway-xref db="Reactome" id="R-XTR-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-DDI-1632852" name="Macroautophagy"/>
            <pathway-xref db="Reactome" id="R-HSA-373752" name="Netrin-1 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-166020" name="Transfer of LPS from LBP carrier to CD14"/>
            <pathway-xref db="Reactome" id="R-DRE-380320" name="Recruitment of NuMA to mitotic centrosomes"/>
            <pathway-xref db="MetaCyc" id="PWY-5475" name="pentagalloylglucose biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-381426" name="Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"/>
            <pathway-xref db="Reactome" id="R-DRE-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7688" name="dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9634285" name="Constitutive Signaling by Overexpressed ERBB2"/>
            <pathway-xref db="Reactome" id="R-MMU-5223345" name="Miscellaneous transport and binding events"/>
            <pathway-xref db="MetaCyc" id="PWY-7713" name="nivalenol biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7412" name="mycinamicin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-141444" name="Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"/>
            <pathway-xref db="MetaCyc" id="PWY-7669" name="equisetin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-380259" name="Loss of Nlp from mitotic centrosomes"/>
            <pathway-xref db="Reactome" id="R-SCE-3108232" name="SUMO E3 ligases SUMOylate target proteins"/>
            <pathway-xref db="Reactome" id="R-HSA-8985586" name="SLIT2:ROBO1 increases RHOA activity"/>
            <pathway-xref db="MetaCyc" id="PWY-7470" name="phosphatidylcholine biosynthesis VII"/>
            <pathway-xref db="Reactome" id="R-MMU-5654687" name="Downstream signaling of activated FGFR1"/>
            <pathway-xref db="Reactome" id="R-DDI-5675482" name="Regulation of necroptotic cell death"/>
            <pathway-xref db="MetaCyc" id="PWY-6944" name="androstenedione degradation I (aerobic)"/>
            <pathway-xref db="MetaCyc" id="PWY-7561" name="tenellin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SPO-199418" name="Negative regulation of the PI3K/AKT network"/>
            <pathway-xref db="MetaCyc" id="PWY-7904" name="tRNA-uridine 2-thiolation (thermophilic bacteria)"/>
            <pathway-xref db="Reactome" id="R-DME-214869" name="Phosphorylated CACT, DL and DIF homodimers dissociate from the TL receptor 'signalling complex'"/>
            <pathway-xref db="MetaCyc" id="PWY-7884" name="lipoprotein posttranslational modification"/>
            <pathway-xref db="MetaCyc" id="PWY-7659" name="viridicatumtoxin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-84" name="resveratrol biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-140837" name="Intrinsic Pathway of Fibrin Clot Formation"/>
            <pathway-xref db="MetaCyc" id="PWY-7250" name="[2Fe-2S] iron-sulfur cluster biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6682" name="dehydrophos biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-2243919" name="Crosslinking of collagen fibrils"/>
            <pathway-xref db="Reactome" id="R-HSA-168164" name="Toll Like Receptor 3 (TLR3) Cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-166016" name="Toll Like Receptor 4 (TLR4) Cascade"/>
            <pathway-xref db="Reactome" id="R-MMU-445989" name="TAK1 activates NFkB by phosphorylation and activation of IKKs complex"/>
            <pathway-xref db="Reactome" id="R-MMU-163210" name="Formation of ATP by chemiosmotic coupling"/>
            <pathway-xref db="MetaCyc" id="PWY-7728" name="(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)"/>
            <pathway-xref db="MetaCyc" id="PWY-6626" name="cytidine-5'-diphosphate-glycerol biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-140534" name="Caspase activation via Death Receptors in the presence of ligand"/>
            <pathway-xref db="Reactome" id="R-CEL-3108232" name="SUMO E3 ligases SUMOylate target proteins"/>
            <pathway-xref db="Reactome" id="R-DME-159231" name="Transport of Mature mRNA Derived from an Intronless Transcript"/>
            <pathway-xref db="Reactome" id="R-CEL-209968" name="Thyroxine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-438066" name="Unblocking of NMDA receptors, glutamate binding and activation"/>
            <pathway-xref db="MetaCyc" id="PWY-5381" name="NAD salvage (plants)"/>
            <pathway-xref db="MetaCyc" id="PWY-7746" name="mycobacterial sulfolipid biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-187024" name="NGF-independant TRKA activation"/>
            <pathway-xref db="MetaCyc" id="PWY-8151" name="cholesterol degradation to androstenedione III (anaerobic)"/>
            <pathway-xref db="Reactome" id="R-HSA-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-166020" name="Transfer of LPS from LBP carrier to CD14"/>
            <pathway-xref db="MetaCyc" id="PWY-7002" name="4-hydroxyacetophenone degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7053" name="docosahexaenoate biosynthesis I (lower eukaryotes)"/>
            <pathway-xref db="Reactome" id="R-MMU-166016" name="Toll Like Receptor 4 (TLR4) Cascade"/>
            <pathway-xref db="Reactome" id="R-RNO-5654687" name="Downstream signaling of activated FGFR1"/>
            <pathway-xref db="Reactome" id="R-HSA-844456" name="The NLRP3 inflammasome"/>
            <pathway-xref db="Reactome" id="R-HSA-170968" name="Frs2-mediated activation"/>
            <pathway-xref db="Reactome" id="R-MMU-1227986" name="Signaling by ERBB2"/>
            <pathway-xref db="Reactome" id="R-MMU-114608" name="Platelet degranulation"/>
            <pathway-xref db="Reactome" id="R-RNO-159231" name="Transport of Mature mRNA Derived from an Intronless Transcript"/>
            <pathway-xref db="Reactome" id="R-HSA-450302" name="activated TAK1 mediates p38 MAPK activation"/>
            <pathway-xref db="Reactome" id="R-MMU-174178" name="APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1"/>
            <pathway-xref db="Reactome" id="R-BTA-2022854" name="Keratan sulfate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8243" name="colanic acid (Escherichia coli K12) biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-844456" name="The NLRP3 inflammasome"/>
            <pathway-xref db="Reactome" id="R-HSA-198203" name="PI3K/AKT activation"/>
            <pathway-xref db="Reactome" id="R-HSA-114608" name="Platelet degranulation"/>
            <pathway-xref db="Reactome" id="R-MMU-199418" name="Negative regulation of the PI3K/AKT network"/>
            <pathway-xref db="MetaCyc" id="PWY-7816" name="poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)"/>
            <pathway-xref db="Reactome" id="R-HSA-428540" name="Activation of RAC1"/>
            <pathway-xref db="MetaCyc" id="PWY-8045" name="cylindrospermopsin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-HSA-168142" name="Toll Like Receptor 10 (TLR10) Cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-198745" name="Signalling to STAT3"/>
            <pathway-xref db="Reactome" id="R-MMU-450302" name="activated TAK1 mediates p38 MAPK activation"/>
            <pathway-xref db="MetaCyc" id="PWY-7719" name="CMP-diacetamido-8-epilegionaminic acid biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7690" name="holomycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-BTA-5223345" name="Miscellaneous transport and binding events"/>
            <pathway-xref db="Reactome" id="R-HSA-9648025" name="EML4 and NUDC in mitotic spindle formation"/>
            <pathway-xref db="MetaCyc" id="PWY-5660" name="taxol biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-2024101" name="CS/DS degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-430116" name="GP1b-IX-V activation signalling"/>
            <pathway-xref db="Reactome" id="R-HSA-5689901" name="Metalloprotease DUBs"/>
            <pathway-xref db="MetaCyc" id="PWY-7696" name="citreoisocoumarin and bikisocoumarin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7342" name="superpathway of nicotine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-68949" name="Orc1 removal from chromatin"/>
            <pathway-xref db="Reactome" id="R-HSA-9013026" name="RHOB GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-BTA-3000178" name="ECM proteoglycans"/>
            <pathway-xref db="Reactome" id="R-HSA-937072" name="TRAF6-mediated induction of TAK1 complex within TLR4 complex"/>
            <pathway-xref db="Reactome" id="R-HSA-187706" name="Signalling to p38 via RIT and RIN"/>
            <pathway-xref db="Reactome" id="R-CEL-8951664" name="Neddylation"/>
            <pathway-xref db="Reactome" id="R-DDI-1660499" name="Synthesis of PIPs at the plasma membrane"/>
            <pathway-xref db="MetaCyc" id="PWY-7592" name="arachidonate biosynthesis III (6-desaturase, mammals)"/>
            <pathway-xref db="Reactome" id="R-HSA-8849932" name="Synaptic adhesion-like molecules"/>
            <pathway-xref db="Reactome" id="R-HSA-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-HSA-9660821" name="ADORA2B mediated anti-inflammatory cytokines production"/>
            <pathway-xref db="MetaCyc" id="PWY-8152" name="androstenedione degradation II (anaerobic)"/>
            <pathway-xref db="MetaCyc" id="PWY-361" name="phenylpropanoid biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9664565" name="Signaling by ERBB2 KD Mutants"/>
            <pathway-xref db="Reactome" id="R-HSA-1971475" name="A tetrasaccharide linker sequence is required for GAG synthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-5617472" name="Activation of anterior HOX genes in hindbrain development during early embryogenesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5984" name="rifamycin B biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6442" name="spermidine hydroxycinnamic acid conjugates biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SPO-159227" name="Transport of the SLBP independent Mature mRNA"/>
            <pathway-xref db="MetaCyc" id="PWY-7530" name="Escherichia coli serotype O:104 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9609736" name="Assembly and cell surface presentation of NMDA receptors"/>
            <pathway-xref db="Reactome" id="R-RNO-450520" name="HuR (ELAVL1) binds and stabilizes mRNA"/>
            <pathway-xref db="Reactome" id="R-MMU-5689896" name="Ovarian tumor domain proteases"/>
            <pathway-xref db="Reactome" id="R-MMU-163125" name="Post-translational modification: synthesis of GPI-anchored proteins"/>
            <pathway-xref db="MetaCyc" id="PWY-6673" name="caffeoylglucarate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9707564" name="Cytoprotection by HMOX1"/>
            <pathway-xref db="MetaCyc" id="PWY-6799" name="fatty acid biosynthesis initiation (plant mitochondria)"/>
            <pathway-xref db="Reactome" id="R-RNO-2022870" name="Chondroitin sulfate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-389977" name="Post-chaperonin tubulin folding pathway"/>
            <pathway-xref db="Reactome" id="R-HSA-9603381" name="Activated NTRK3 signals through PI3K"/>
            <pathway-xref db="Reactome" id="R-HSA-9034013" name="NTF3 activates NTRK3 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-6804115" name="TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"/>
            <pathway-xref db="MetaCyc" id="PWY-7706" name="dapdiamides biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7318" name="dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7986" name="anguibactin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9696270" name="RND2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-3214842" name="HDMs demethylate histones"/>
            <pathway-xref db="Reactome" id="R-SCE-163210" name="Formation of ATP by chemiosmotic coupling"/>
            <pathway-xref db="Reactome" id="R-DME-214874" name="PLL kinase binds to TUB in the TL receptor 'signalling complex'"/>
            <pathway-xref db="Reactome" id="R-HSA-9696264" name="RND3 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-9028731" name="Activated NTRK2 signals through FRS2 and FRS3"/>
            <pathway-xref db="MetaCyc" id="PWY-7407" name="aurachin A, B, C and D biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-141444" name="Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"/>
            <pathway-xref db="Reactome" id="R-HSA-9013149" name="RAC1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-9615933" name="Postmitotic nuclear pore complex (NPC) reformation"/>
            <pathway-xref db="Reactome" id="R-HSA-9013423" name="RAC3 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-6310" name="aloesone biosynthesis II"/>
            <pathway-xref db="Reactome" id="R-SCE-199418" name="Negative regulation of the PI3K/AKT network"/>
            <pathway-xref db="Reactome" id="R-HSA-428542" name="Regulation of commissural axon pathfinding by SLIT and ROBO"/>
            <pathway-xref db="Reactome" id="R-DME-4615885" name="SUMOylation of DNA replication proteins"/>
            <pathway-xref db="MetaCyc" id="PWY-7815" name="poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)"/>
            <pathway-xref db="Reactome" id="R-RNO-159236" name="Transport of Mature mRNA derived from an Intron-Containing Transcript"/>
            <pathway-xref db="MetaCyc" id="PWY-5794" name="malonate degradation I (biotin-independent)"/>
            <pathway-xref db="Reactome" id="R-HSA-9020702" name="Interleukin-1 signaling"/>
            <pathway-xref db="Reactome" id="R-DRE-380259" name="Loss of Nlp from mitotic centrosomes"/>
            <pathway-xref db="MetaCyc" id="PWY-7712" name="deoxynivalenol biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-193634" name="Axonal growth inhibition (RHOA activation)"/>
            <pathway-xref db="Reactome" id="R-MMU-187577" name="SCF(Skp2)-mediated degradation of p27/p21"/>
            <pathway-xref db="Reactome" id="R-MMU-6794361" name="Neurexins and neuroligins"/>
            <pathway-xref db="MetaCyc" id="PWY-5466" name="matairesinol biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-390522" name="Striated Muscle Contraction"/>
            <pathway-xref db="MetaCyc" id="PWY-5461" name="betanidin degradation"/>
            <pathway-xref db="Reactome" id="R-SPO-163210" name="Formation of ATP by chemiosmotic coupling"/>
            <pathway-xref db="Reactome" id="R-HSA-844623" name="The IPAF inflammasome"/>
            <pathway-xref db="Reactome" id="R-SCE-5223345" name="Miscellaneous transport and binding events"/>
            <pathway-xref db="Reactome" id="R-HSA-6803207" name="TP53 Regulates Transcription of Caspase Activators and Caspases"/>
            <pathway-xref db="Reactome" id="R-HSA-4615885" name="SUMOylation of DNA replication proteins"/>
            <pathway-xref db="MetaCyc" id="PWY-7382" name="lipoate biosynthesis and incorporation IV (yeast)"/>
            <pathway-xref db="MetaCyc" id="PWY-8035" name="streptovaricin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-6803207" name="TP53 Regulates Transcription of Caspase Activators and Caspases"/>
            <pathway-xref db="MetaCyc" id="PWY-7583" name="arachidonate biosynthesis II (bacteria)"/>
            <pathway-xref db="MetaCyc" id="PWY-7460" name="2-O-acetyl-3-O-trans-coutarate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-6807004" name="Negative regulation of MET activity"/>
            <pathway-xref db="MetaCyc" id="PWY-7888" name="tRNA-uridine 2-thiolation (cytoplasmic)"/>
            <pathway-xref db="Reactome" id="R-HSA-9032759" name="NTRK2 activates RAC1"/>
            <pathway-xref db="Reactome" id="R-HSA-877300" name="Interferon gamma signaling"/>
            <pathway-xref db="Reactome" id="R-DDI-9013149" name="RAC1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DME-9013406" name="RHOQ GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-8863795" name="Downregulation of ERBB2 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-8051" name="anandamide biosynthesis I"/>
            <pathway-xref db="Reactome" id="R-HSA-75892" name="Platelet Adhesion to exposed collagen"/>
            <pathway-xref db="Reactome" id="R-MMU-4615885" name="SUMOylation of DNA replication proteins"/>
            <pathway-xref db="Reactome" id="R-MMU-8857538" name="PTK6 promotes HIF1A stabilization"/>
            <pathway-xref db="Reactome" id="R-HSA-9620244" name="Long-term potentiation"/>
            <pathway-xref db="Reactome" id="R-RNO-444821" name="Relaxin receptors"/>
            <pathway-xref db="Reactome" id="R-HSA-400253" name="Circadian Clock"/>
            <pathway-xref db="Reactome" id="R-HSA-3656225" name="Defective CHST6 causes MCDC1"/>
            <pathway-xref db="Reactome" id="R-SPO-9696270" name="RND2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-8875360" name="InlB-mediated entry of Listeria monocytogenes into host cell"/>
            <pathway-xref db="Reactome" id="R-HSA-1606341" name="IRF3 mediated activation of type 1 IFN"/>
            <pathway-xref db="Reactome" id="R-SSC-375281" name="Hormone ligand-binding receptors"/>
            <pathway-xref db="Reactome" id="R-HSA-8863795" name="Downregulation of ERBB2 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-8231" name="Escherichia coli serotype O:127 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-167044" name="Signalling to RAS"/>
            <pathway-xref db="Reactome" id="R-MMU-8949613" name="Cristae formation"/>
            <pathway-xref db="Reactome" id="R-RNO-438066" name="Unblocking of NMDA receptors, glutamate binding and activation"/>
            <pathway-xref db="Reactome" id="R-MMU-9013408" name="RHOG GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-SPO-9615933" name="Postmitotic nuclear pore complex (NPC) reformation"/>
            <pathway-xref db="Reactome" id="R-MMU-6807004" name="Negative regulation of MET activity"/>
            <pathway-xref db="Reactome" id="R-HSA-9603505" name="NTRK3 as a dependence receptor"/>
            <pathway-xref db="Reactome" id="R-MMU-187042" name="TRKA activation by NGF"/>
            <pathway-xref db="Reactome" id="R-HSA-8857538" name="PTK6 promotes HIF1A stabilization"/>
            <pathway-xref db="Reactome" id="R-HSA-3595172" name="Defective CHST3 causes SEDCJD"/>
            <pathway-xref db="Reactome" id="R-RNO-8849932" name="Synaptic adhesion-like molecules"/>
            <pathway-xref db="Reactome" id="R-HSA-9665251" name="Resistance of ERBB2 KD mutants to lapatinib"/>
            <pathway-xref db="MetaCyc" id="PWY-81" name="toluene degradation to benzoyl-CoA (anaerobic)"/>
            <pathway-xref db="MetaCyc" id="PWY-7532" name="acetylaszonalenin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5835" name="geranyl acetate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6036" name="cardenolide glucosides biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-1839117" name="Signaling by cytosolic FGFR1 fusion mutants"/>
            <pathway-xref db="Reactome" id="R-MMU-2022870" name="Chondroitin sulfate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CFA-3000178" name="ECM proteoglycans"/>
            <pathway-xref db="Reactome" id="R-HSA-9013418" name="RHOBTB2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-9665348" name="Signaling by ERBB2 ECD mutants"/>
            <pathway-xref db="MetaCyc" id="PWY-7671" name="saframycin A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-5689901" name="Metalloprotease DUBs"/>
            <pathway-xref db="Reactome" id="R-HSA-9013408" name="RHOG GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-7693" name="guadinomine B biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-936964" name="Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon"/>
            <pathway-xref db="Reactome" id="R-HSA-9665246" name="Resistance of ERBB2 KD mutants to neratinib"/>
            <pathway-xref db="Reactome" id="R-MMU-9013418" name="RHOBTB2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-844455" name="The NLRP1 inflammasome"/>
            <pathway-xref db="MetaCyc" id="PWY-8166" name="emodin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-375281" name="Hormone ligand-binding receptors"/>
            <pathway-xref db="Reactome" id="R-HSA-381426" name="Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"/>
            <pathway-xref db="Reactome" id="R-BTA-2022923" name="Dermatan sulfate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-72163" name="mRNA Splicing - Major Pathway"/>
            <pathway-xref db="MetaCyc" id="PWY-7989" name="acinetoferrin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7677" name="rosamicin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7261" name="anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)"/>
            <pathway-xref db="Reactome" id="R-HSA-9032500" name="Activated NTRK2 signals through FYN"/>
            <pathway-xref db="Reactome" id="R-MMU-69231" name="Cyclin D associated events in G1"/>
            <pathway-xref db="Reactome" id="R-HSA-9665250" name="Resistance of ERBB2 KD mutants to AEE788"/>
            <pathway-xref db="MetaCyc" id="PWY-7702" name="sch210971 and sch210972 biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-5682910" name="LGI-ADAM interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-9028335" name="Activated NTRK2 signals through PI3K"/>
            <pathway-xref db="Reactome" id="R-CFA-109704" name="PI3K Cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-9013148" name="CDC42 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-6558" name="heparan sulfate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-168176" name="Toll Like Receptor 5 (TLR5) Cascade"/>
            <pathway-xref db="Reactome" id="R-MMU-75892" name="Platelet Adhesion to exposed collagen"/>
            <pathway-xref db="Reactome" id="R-HSA-8950505" name="Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"/>
            <pathway-xref db="MetaCyc" id="PWY-6056" name="dimethylsulfoniopropanoate degradation II (cleavage)"/>
            <pathway-xref db="Reactome" id="R-HSA-168928" name="DDX58/IFIH1-mediated induction of interferon-alpha/beta"/>
            <pathway-xref db="Reactome" id="R-HSA-166058" name="MyD88:MAL(TIRAP) cascade initiated on plasma membrane"/>
            <pathway-xref db="MetaCyc" id="PWY-7452" name="cyanidin dimalonylglucoside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-168138" name="Toll Like Receptor 9 (TLR9) Cascade"/>
            <pathway-xref db="MetaCyc" id="PWY-8038" name="naphthomycin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7737" name="thiocoraline biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-9013148" name="CDC42 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-7458" name="violdelphin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7672" name="fusaric acid biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7529" name="CMP-N-acetyl-7-O-acetylneuraminate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-8985801" name="Regulation of cortical dendrite branching"/>
            <pathway-xref db="Reactome" id="R-HSA-9662360" name="Sensory processing of sound by inner hair cells of the cochlea"/>
            <pathway-xref db="Reactome" id="R-CEL-376176" name="Signaling by ROBO receptors"/>
            <pathway-xref db="Reactome" id="R-HSA-4641263" name="Regulation of FZD by ubiquitination"/>
            <pathway-xref db="MetaCyc" id="PWY-5679" name="clavulanate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9013409" name="RHOJ GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-7511" name="protein ubiquitination"/>
            <pathway-xref db="MetaCyc" id="PWY-8075" name="(Kdo)2-lipid A biosynthesis (P. putida)"/>
            <pathway-xref db="MetaCyc" id="PWY-7821" name="tunicamycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-450520" name="HuR (ELAVL1) binds and stabilizes mRNA"/>
            <pathway-xref db="Reactome" id="R-HSA-8949613" name="Cristae formation"/>
            <pathway-xref db="Reactome" id="R-DME-159230" name="Transport of the SLBP Dependant Mature mRNA"/>
            <pathway-xref db="MetaCyc" id="PWY-6289" name="petrobactin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-428890" name="Role of ABL in ROBO-SLIT signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-4641263" name="Regulation of FZD by ubiquitination"/>
            <pathway-xref db="Reactome" id="R-MMU-9032759" name="NTRK2 activates RAC1"/>
            <pathway-xref db="Reactome" id="R-RNO-936440" name="Negative regulators of DDX58/IFIH1 signaling"/>
            <pathway-xref db="Reactome" id="R-DDI-1169092" name="Activation of RAS in B cells"/>
            <pathway-xref db="Reactome" id="R-RNO-163125" name="Post-translational modification: synthesis of GPI-anchored proteins"/>
            <pathway-xref db="Reactome" id="R-MMU-3000178" name="ECM proteoglycans"/>
            <pathway-xref db="Reactome" id="R-RNO-9034793" name="Activated NTRK3 signals through PLCG1"/>
            <pathway-xref db="MetaCyc" id="PWY-7265" name="lampranthin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-198203" name="PI3K/AKT activation"/>
            <pathway-xref db="Reactome" id="R-HSA-9013406" name="RHOQ GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-7818" name="type IV lipoteichoic acid biosynthesis (S. pneumoniae)"/>
            <pathway-xref db="Reactome" id="R-GGA-517856" name="TLR2 subfamily cascade"/>
            <pathway-xref db="MetaCyc" id="PWY-7624" name="nystatin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6397" name="mycolyl-arabinogalactan-peptidoglycan complex biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-446388" name="Regulation of cytoskeletal remodeling and cell spreading by IPP complex components"/>
            <pathway-xref db="MetaCyc" id="PWY-7601" name="arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)"/>
            <pathway-xref db="MetaCyc" id="PWY-8249" name="xanthommatin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-2467813" name="Separation of Sister Chromatids"/>
            <pathway-xref db="Reactome" id="R-DRE-8854050" name="FBXL7 down-regulates AURKA during mitotic entry and in early mitosis"/>
            <pathway-xref db="Reactome" id="R-RNO-8951664" name="Neddylation"/>
            <pathway-xref db="Reactome" id="R-DME-214842" name="DL and DIF homodimers bind to TUB and phosphorylated PLL in the TL receptor 'signalling complex'"/>
            <pathway-xref db="Reactome" id="R-HSA-2467813" name="Separation of Sister Chromatids"/>
            <pathway-xref db="Reactome" id="R-MMU-445355" name="Smooth Muscle Contraction"/>
            <pathway-xref db="Reactome" id="R-HSA-8936459" name="RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"/>
            <pathway-xref db="MetaCyc" id="PWY-7983" name="pseudomonine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DDI-202670" name="ERKs are inactivated"/>
            <pathway-xref db="Reactome" id="R-MMU-388844" name="Receptor-type tyrosine-protein phosphatases"/>
            <pathway-xref db="MetaCyc" id="PWY-5400" name="amaranthin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-8854518" name="AURKA Activation by TPX2"/>
            <pathway-xref db="Reactome" id="R-MMU-977606" name="Regulation of Complement cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-168181" name="Toll Like Receptor 7/8 (TLR7/8) Cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-9026527" name="Activated NTRK2 signals through PLCG1"/>
            <pathway-xref db="Reactome" id="R-MMU-170968" name="Frs2-mediated activation"/>
            <pathway-xref db="MetaCyc" id="PWY-6322" name="phosphinothricin tripeptide biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-69231" name="Cyclin D associated events in G1"/>
            <pathway-xref db="MetaCyc" id="PWY-5710" name="capsaicin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-DRE-9696264" name="RND3 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-5437" name="L-threonine degradation I"/>
            <pathway-xref db="MetaCyc" id="PWY-7474" name="avenacin A-2 biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9034015" name="Signaling by NTRK3 (TRKC)"/>
            <pathway-xref db="Reactome" id="R-SCE-8949613" name="Cristae formation"/>
            <pathway-xref db="Reactome" id="R-MMU-2562578" name="TRIF-mediated programmed cell death"/>
            <pathway-xref db="Reactome" id="R-HSA-2562578" name="TRIF-mediated programmed cell death"/>
            <pathway-xref db="Reactome" id="R-DDI-5621575" name="CD209 (DC-SIGN) signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-844455" name="The NLRP1 inflammasome"/>
            <pathway-xref db="Reactome" id="R-DME-376176" name="Signaling by ROBO receptors"/>
            <pathway-xref db="Reactome" id="R-MMU-159227" name="Transport of the SLBP independent Mature mRNA"/>
            <pathway-xref db="Reactome" id="R-MMU-159236" name="Transport of Mature mRNA derived from an Intron-Containing Transcript"/>
            <pathway-xref db="MetaCyc" id="PWY-7172" name="flavonol acylglucoside biosynthesis III - quercetin derivatives"/>
            <pathway-xref db="MetaCyc" id="PWY-6314" name="plumbagin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-174178" name="APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1"/>
            <pathway-xref db="Reactome" id="R-HSA-376176" name="Signaling by ROBO receptors"/>
            <pathway-xref db="Reactome" id="R-GGA-451514" name="MyD88:TIRAP-dependent cascade initiated on plasma membrane"/>
            <pathway-xref db="MetaCyc" id="PWY-6032" name="digitoxigenin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CFA-418555" name="G alpha (s) signalling events"/>
            <pathway-xref db="Reactome" id="R-DRE-8951664" name="Neddylation"/>
            <pathway-xref db="MetaCyc" id="PWY-7473" name="avenacin A-1 biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-6803207" name="TP53 Regulates Transcription of Caspase Activators and Caspases"/>
            <pathway-xref db="Reactome" id="R-GGA-388844" name="Receptor-type tyrosine-protein phosphatases"/>
            <pathway-xref db="Reactome" id="R-HSA-8854518" name="AURKA Activation by TPX2"/>
            <pathway-xref db="MetaCyc" id="PWY-7716" name="penicillin G and penicillin V biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DDI-1483248" name="Synthesis of PIPs at the ER membrane"/>
            <pathway-xref db="MetaCyc" id="PWY-6190" name="2,4-dichlorotoluene degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7475" name="des-methyl avenacin A-1 biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7045" name="mithramycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-9034013" name="NTF3 activates NTRK3 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-9013106" name="RHOC GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-216083" name="Integrin cell surface interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-2022923" name="Dermatan sulfate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-8941413" name="Events associated with phagocytolytic activity of PMN cells"/>
            <pathway-xref db="Reactome" id="R-DME-159236" name="Transport of Mature mRNA derived from an Intron-Containing Transcript"/>
            <pathway-xref db="Reactome" id="R-DDI-193648" name="NRAGE signals death through JNK"/>
            <pathway-xref db="Reactome" id="R-GGA-2022854" name="Keratan sulfate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-BTA-1971475" name="A tetrasaccharide linker sequence is required for GAG synthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-3656244" name="Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)"/>
            <pathway-xref db="MetaCyc" id="PWY-5473" name="hydroxycinnamic acid serotonin amides biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-109704" name="PI3K Cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-3134975" name="Regulation of innate immune responses to cytosolic DNA"/>
            <pathway-xref db="Reactome" id="R-HSA-159231" name="Transport of Mature mRNA Derived from an Intronless Transcript"/>
            <pathway-xref db="Reactome" id="R-HSA-3270619" name="IRF3-mediated induction of type I IFN"/>
            <pathway-xref db="Reactome" id="R-DDI-354192" name="Integrin signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-975871" name="MyD88 cascade initiated on plasma membrane"/>
            <pathway-xref db="Reactome" id="R-MMU-3134975" name="Regulation of innate immune responses to cytosolic DNA"/>
            <pathway-xref db="MetaCyc" id="PWY-6378" name="putrebactin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DRE-8849932" name="Synaptic adhesion-like molecules"/>
            <pathway-xref db="Reactome" id="R-MMU-166020" name="Transfer of LPS from LBP carrier to CD14"/>
            <pathway-xref db="Reactome" id="R-DRE-380270" name="Recruitment of mitotic centrosome proteins and complexes"/>
            <pathway-xref db="Reactome" id="R-HSA-8955332" name="Carboxyterminal post-translational modifications of tubulin"/>
            <pathway-xref db="Reactome" id="R-HSA-163125" name="Post-translational modification: synthesis of GPI-anchored proteins"/>
            <pathway-xref db="Reactome" id="R-HSA-975163" name="IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation"/>
            <pathway-xref db="Reactome" id="R-RNO-9696264" name="RND3 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-7738" name="polyacyltrehalose biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-CFA-168138" name="Toll Like Receptor 9 (TLR9) Cascade"/>
            <pathway-xref db="MetaCyc" id="PWY-6462" name="peptidoglycan cross-bridge biosynthesis III (Enterococcus faecalis)"/>
            <pathway-xref db="Reactome" id="R-RNO-429947" name="Deadenylation of mRNA"/>
            <pathway-xref db="Reactome" id="R-DDI-392517" name="Rap1 signalling"/>
            <pathway-xref db="Reactome" id="R-HSA-2022870" name="Chondroitin sulfate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8058" name="2-deoxy-D-ribose degradation II"/>
            <pathway-xref db="MetaCyc" id="PWY-7577" name="ferrichrome biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7940" name="lauryl-hydroxychlorobactene glucoside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9026519" name="Activated NTRK2 signals through RAS"/>
            <pathway-xref db="Reactome" id="R-MMU-9026527" name="Activated NTRK2 signals through PLCG1"/>
            <pathway-xref db="Reactome" id="R-MMU-380284" name="Loss of proteins required for interphase microtubule organization from the centrosome"/>
            <pathway-xref db="MetaCyc" id="PWY-6039" name="chlorogenic acid biosynthesis I"/>
            <pathway-xref db="Reactome" id="R-SPO-3108232" name="SUMO E3 ligases SUMOylate target proteins"/>
            <pathway-xref db="Reactome" id="R-DME-159227" name="Transport of the SLBP independent Mature mRNA"/>
            <pathway-xref db="Reactome" id="R-DME-388844" name="Receptor-type tyrosine-protein phosphatases"/>
            <pathway-xref db="Reactome" id="R-MMU-9028731" name="Activated NTRK2 signals through FRS2 and FRS3"/>
            <pathway-xref db="MetaCyc" id="PWY-8210" name="pyrrolomycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9028731" name="Activated NTRK2 signals through FRS2 and FRS3"/>
            <pathway-xref db="MetaCyc" id="PWY-5292" name="vindoline, vindorosine and vinblastine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-3270619" name="IRF3-mediated induction of type I IFN"/>
            <pathway-xref db="MetaCyc" id="PWY-7367" name="phosphatidylcholine resynthesis via glycerophosphocholine"/>
            <pathway-xref db="Reactome" id="R-MMU-2022923" name="Dermatan sulfate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7907" name="(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9665737" name="Drug resistance in ERBB2 TMD/JMD mutants"/>
            <pathway-xref db="MetaCyc" id="PWY-7555" name="alpha-cyclopiazonate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-3000178" name="ECM proteoglycans"/>
            <pathway-xref db="Reactome" id="R-HSA-9013106" name="RHOC GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-5673000" name="RAF activation"/>
            <pathway-xref db="MetaCyc" id="PWY-7735" name="echinomycin and triostin A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-2022854" name="Keratan sulfate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SPO-5223345" name="Miscellaneous transport and binding events"/>
            <pathway-xref db="MetaCyc" id="PWY-7621" name="autoinducer CAI-1 biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5994" name="palmitate biosynthesis I (type I fatty acid synthase)"/>
            <pathway-xref db="Reactome" id="R-CEL-159236" name="Transport of Mature mRNA derived from an Intron-Containing Transcript"/>
            <pathway-xref db="Reactome" id="R-RNO-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-8047" name="bryostatin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7711" name="calonectrin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-3560783" name="Defective B4GALT7 causes EDS, progeroid type"/>
            <pathway-xref db="MetaCyc" id="PWY-6948" name="sitosterol degradation to androstenedione"/>
            <pathway-xref db="MetaCyc" id="PWY-7100" name="spinosyn A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CFA-2024101" name="CS/DS degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-5602680" name="MyD88 deficiency (TLR5)"/>
            <pathway-xref db="Reactome" id="R-HSA-375281" name="Hormone ligand-binding receptors"/>
            <pathway-xref db="MetaCyc" id="PWY-8179" name="platensimycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9665245" name="Resistance of ERBB2 KD mutants to tesevatinib"/>
            <pathway-xref db="Reactome" id="R-HSA-9013404" name="RAC2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DRE-450520" name="HuR (ELAVL1) binds and stabilizes mRNA"/>
            <pathway-xref db="Reactome" id="R-XTR-3214842" name="HDMs demethylate histones"/>
            <pathway-xref db="Reactome" id="R-MMU-9010553" name="Regulation of expression of SLITs and ROBOs"/>
            <pathway-xref db="Reactome" id="R-RNO-9026527" name="Activated NTRK2 signals through PLCG1"/>
            <pathway-xref db="Reactome" id="R-RNO-2024101" name="CS/DS degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-8985586" name="SLIT2:ROBO1 increases RHOA activity"/>
            <pathway-xref db="Reactome" id="R-DRE-2022854" name="Keratan sulfate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8133" name="succinoglycan biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-177929" name="Signaling by EGFR"/>
            <pathway-xref db="Reactome" id="R-GGA-9028731" name="Activated NTRK2 signals through FRS2 and FRS3"/>
            <pathway-xref db="MetaCyc" id="PWY-7564" name="bacimethrin and bacimethrin pyrophosphate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8040" name="ansatrienin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-GGA-433822" name="NFkB and MAPK activation mediated by TRAF6"/>
            <pathway-xref db="MetaCyc" id="PWY-8272" name="Escherichia coli serotype O:49 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-9013424" name="RHOV GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-5686938" name="Regulation of TLR by endogenous ligand"/>
            <pathway-xref db="Reactome" id="R-MMU-2022857" name="Keratan sulfate degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-5316" name="nicotine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DRE-429947" name="Deadenylation of mRNA"/>
            <pathway-xref db="Reactome" id="R-HSA-9665686" name="Signaling by ERBB2 TMD/JMD mutants"/>
            <pathway-xref db="Reactome" id="R-MMU-2500257" name="Resolution of Sister Chromatid Cohesion"/>
            <pathway-xref db="Reactome" id="R-HSA-9034793" name="Activated NTRK3 signals through PLCG1"/>
            <pathway-xref db="Reactome" id="R-CEL-9615933" name="Postmitotic nuclear pore complex (NPC) reformation"/>
            <pathway-xref db="Reactome" id="R-HSA-9013957" name="TLR3-mediated TICAM1-dependent programmed cell death"/>
            <pathway-xref db="MetaCyc" id="PWY-7727" name="docosahexaenoate biosynthesis IV (4-desaturase, mammals)"/>
            <pathway-xref db="Reactome" id="R-HSA-8873719" name="RAB geranylgeranylation"/>
            <pathway-xref db="MetaCyc" id="PWY-6312" name="barbaloin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DDI-5674135" name="MAP2K and MAPK activation"/>
            <pathway-xref db="Reactome" id="R-HSA-216083" name="Integrin cell surface interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-8939902" name="Regulation of RUNX2 expression and activity"/>
            <pathway-xref db="MetaCyc" id="PWY-761" name="rhizobactin 1021 biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-1971475" name="A tetrasaccharide linker sequence is required for GAG synthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7673" name="fusarin C biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-209968" name="Thyroxine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7563" name="bassianin and desmethylbassianin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7214" name="baicalein degradation (hydrogen peroxide detoxification)"/>
            <pathway-xref db="MetaCyc" id="PWY-6672" name="cis-geranyl-CoA degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-9652282" name="Drug-mediated inhibition of ERBB2 signaling"/>
            <pathway-xref db="Reactome" id="R-SSC-168138" name="Toll Like Receptor 9 (TLR9) Cascade"/>
            <pathway-xref db="MetaCyc" id="PWY-6722" name="candicidin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-BTA-2022870" name="Chondroitin sulfate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-380259" name="Loss of Nlp from mitotic centrosomes"/>
            <pathway-xref db="Reactome" id="R-HSA-418555" name="G alpha (s) signalling events"/>
            <pathway-xref db="Reactome" id="R-DRE-5620912" name="Anchoring of the basal body to the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-DRE-9013406" name="RHOQ GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-1461957" name="Beta defensins"/>
            <pathway-xref db="Reactome" id="R-HSA-5223345" name="Miscellaneous transport and binding events"/>
            <pathway-xref db="Reactome" id="R-HSA-444821" name="Relaxin receptors"/>
            <pathway-xref db="Reactome" id="R-HSA-168188" name="Toll Like Receptor TLR6:TLR2 Cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-917937" name="Iron uptake and transport"/>
            <pathway-xref db="Reactome" id="R-HSA-9637628" name="Modulation by Mtb of host immune system"/>
            <pathway-xref db="Reactome" id="R-HSA-166166" name="MyD88-independent TLR4 cascade"/>
            <pathway-xref db="MetaCyc" id="PWY-5875" name="staphyloxanthin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-4922" name="6-methoxymellein biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-9013406" name="RHOQ GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-3595177" name="Defective CHSY1 causes TPBS"/>
            <pathway-xref db="MetaCyc" id="PWY-8157" name="avenanthramide biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6316" name="aromatic polyketides biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5284" name="shisonin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6848" name="rutin degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7050" name="icosapentaenoate biosynthesis IV (bacteria)"/>
            <pathway-xref db="MetaCyc" id="PWYG-321" name="mycolate biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-MMU-170984" name="ARMS-mediated activation"/>
            <pathway-xref db="Reactome" id="R-HSA-2243919" name="Crosslinking of collagen fibrils"/>
            <pathway-xref db="Reactome" id="R-DRE-917937" name="Iron uptake and transport"/>
            <pathway-xref db="Reactome" id="R-HSA-3595174" name="Defective CHST14 causes EDS, musculocontractural type"/>
            <pathway-xref db="MetaCyc" id="PWY-6922" name="L-Ndelta-acetylornithine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5846" name="colchicine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5313" name="superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)"/>
            <pathway-xref db="Reactome" id="R-HSA-3656243" name="Defective ST3GAL3 causes MCT12 and EIEE15"/>
            <pathway-xref db="Reactome" id="R-DRE-8854518" name="AURKA Activation by TPX2"/>
            <pathway-xref db="Reactome" id="R-HSA-9660826" name="Purinergic signaling in leishmaniasis infection"/>
            <pathway-xref db="MetaCyc" id="PWY-7708" name="lyngbyatoxin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CFA-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-1236974" name="ER-Phagosome pathway"/>
            <pathway-xref db="Reactome" id="R-DRE-9013148" name="CDC42 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-8117" name="colibactin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-6803207" name="TP53 Regulates Transcription of Caspase Activators and Caspases"/>
            <pathway-xref db="Reactome" id="R-RNO-1474228" name="Degradation of the extracellular matrix"/>
            <pathway-xref db="MetaCyc" id="PWY-7029" name="terminal olefins biosynthesis II"/>
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            <pathway-xref db="Reactome" id="R-SPO-159231" name="Transport of Mature mRNA Derived from an Intronless Transcript"/>
            <pathway-xref db="Reactome" id="R-DDI-5673001" name="RAF/MAP kinase cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-5654687" name="Downstream signaling of activated FGFR1"/>
            <pathway-xref db="Reactome" id="R-MMU-380270" name="Recruitment of mitotic centrosome proteins and complexes"/>
            <pathway-xref db="Reactome" id="R-HSA-428543" name="Inactivation of CDC42 and RAC1"/>
            <pathway-xref db="Reactome" id="R-HSA-6794361" name="Neurexins and neuroligins"/>
            <pathway-xref db="Reactome" id="R-HSA-9013973" name="TICAM1-dependent activation of IRF3/IRF7"/>
            <pathway-xref db="MetaCyc" id="PWY-7694" name="zwittermicin A biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-HSA-1227986" name="Signaling by ERBB2"/>
            <pathway-xref db="Reactome" id="R-MMU-9013406" name="RHOQ GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-SPO-159236" name="Transport of Mature mRNA derived from an Intron-Containing Transcript"/>
            <pathway-xref db="Reactome" id="R-HSA-4608870" name="Asymmetric localization of PCP proteins"/>
            <pathway-xref db="Reactome" id="R-DRE-3270619" name="IRF3-mediated induction of type I IFN"/>
            <pathway-xref db="MetaCyc" id="PWY-5139" name="pelargonidin conjugates biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6824" name="justicidin B biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-983231" name="Factors involved in megakaryocyte development and platelet production"/>
            <pathway-xref db="MetaCyc" id="PWY-5477" name="gallotannin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-9648025" name="EML4 and NUDC in mitotic spindle formation"/>
            <pathway-xref db="Reactome" id="R-MMU-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-977606" name="Regulation of Complement cascade"/>
            <pathway-xref db="Reactome" id="R-MMU-8849932" name="Synaptic adhesion-like molecules"/>
            <pathway-xref db="MetaCyc" id="PWY-7599" name="anditomin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-177504" name="Retrograde neurotrophin signalling"/>
            <pathway-xref db="Reactome" id="R-RNO-5673001" name="RAF/MAP kinase cascade"/>
            <pathway-xref db="MetaCyc" id="PWY-7401" name="crotonate fermentation (to acetate and cyclohexane carboxylate)"/>
            <pathway-xref db="Reactome" id="R-DDI-1660516" name="Synthesis of PIPs at the early endosome membrane"/>
            <pathway-xref db="MetaCyc" id="PWY-6415" name="L-ascorbate biosynthesis V (euglena, D-galacturonate pathway)"/>
            <pathway-xref db="MetaCyc" id="PWY-6679" name="jadomycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-CFA-375281" name="Hormone ligand-binding receptors"/>
            <pathway-xref db="Reactome" id="R-HSA-5603041" name="IRAK4 deficiency (TLR2/4)"/>
            <pathway-xref db="Reactome" id="R-MMU-9020702" name="Interleukin-1 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-7168" name="flavonol acylglucoside biosynthesis I - kaempferol derivatives"/>
            <pathway-xref db="Reactome" id="R-DME-214844" name="DL and DIF homodimers complexed with CACT are all phosphorylated in the TL receptor 'signalling complex'"/>
            <pathway-xref db="MetaCyc" id="PWY-7127" name="CDP-D-mannitol biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5307" name="gentiodelphin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-2022857" name="Keratan sulfate degradation"/>
            <pathway-xref db="Reactome" id="R-RNO-216083" name="Integrin cell surface interactions"/>
            <pathway-xref db="Reactome" id="R-RNO-199418" name="Negative regulation of the PI3K/AKT network"/>
            <pathway-xref db="MetaCyc" id="PWY-8036" name="chaxamycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-937041" name="IKK complex recruitment mediated by RIP1"/>
            <pathway-xref db="Reactome" id="R-HSA-2024101" name="CS/DS degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-9013026" name="RHOB GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-1971475" name="A tetrasaccharide linker sequence is required for GAG synthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-6804115" name="TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"/>
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            <pathway-xref db="MetaCyc" id="PWY-6971" name="oleandomycin biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-7981" name="alpha-dystroglycan glycosylation"/>
            <pathway-xref db="Reactome" id="R-MMU-844455" name="The NLRP1 inflammasome"/>
            <pathway-xref db="Reactome" id="R-RNO-177504" name="Retrograde neurotrophin signalling"/>
            <pathway-xref db="Reactome" id="R-HSA-429947" name="Deadenylation of mRNA"/>
            <pathway-xref db="MetaCyc" id="PWY-7547" name="prodigiosin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-2881" name="cytokinins 7-N-glucoside biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8106" name="queuosine biosynthesis III (queuosine salvage)"/>
            <pathway-xref db="MetaCyc" id="PWY-7660" name="tryptoquialanine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-936964" name="Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon"/>
            <pathway-xref db="MetaCyc" id="PWY-5756" name="saponin biosynthesis II"/>
            <pathway-xref db="MetaCyc" id="PWY-5339" name="chalcone 2'-O-glucoside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-376176" name="Signaling by ROBO receptors"/>
            <pathway-xref db="Reactome" id="R-CEL-72163" name="mRNA Splicing - Major Pathway"/>
            <pathway-xref db="Reactome" id="R-CFA-8951664" name="Neddylation"/>
            <pathway-xref db="Reactome" id="R-XTR-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-BTA-2024101" name="CS/DS degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7018" name="paromomycin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7419" name="FR-900098 and FR-33289 antibiotics biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-9013149" name="RAC1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-140534" name="Caspase activation via Death Receptors in the presence of ligand"/>
            <pathway-xref db="MetaCyc" id="PWY-7950" name="diadinoxanthin and fucoxanthin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6297" name="tuberonate glucoside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-9707616" name="Heme signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-450520" name="HuR (ELAVL1) binds and stabilizes mRNA"/>
            <pathway-xref db="MetaCyc" id="PWY-7930" name="pyoluteorin biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-MMU-937041" name="IKK complex recruitment mediated by RIP1"/>
            <pathway-xref db="Reactome" id="R-HSA-2022854" name="Keratan sulfate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5161" name="6'-deoxychalcone metabolism"/>
            <pathway-xref db="MetaCyc" id="PWY-7569" name="arginomycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-2022854" name="Keratan sulfate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-4641263" name="Regulation of FZD by ubiquitination"/>
            <pathway-xref db="Reactome" id="R-RNO-9032759" name="NTRK2 activates RAC1"/>
            <pathway-xref db="MetaCyc" id="PWY-7982" name="pinoresinol degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-168638" name="NOD1/2 Signaling Pathway"/>
            <pathway-xref db="Reactome" id="R-MMU-3108232" name="SUMO E3 ligases SUMOylate target proteins"/>
            <pathway-xref db="Reactome" id="R-DDI-5213460" name="RIPK1-mediated regulated necrosis"/>
            <pathway-xref db="MetaCyc" id="PWY-8244" name="Escherichia coli serotype O:177 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9014325" name="TICAM1,TRAF6-dependent induction of TAK1 complex"/>
            <pathway-xref db="Reactome" id="R-HSA-177504" name="Retrograde neurotrophin signalling"/>
            <pathway-xref db="MetaCyc" id="PWY-8232" name="Shigella boydii serotype 6 O antigen biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7817" name="type I lipoteichoic acid biosynthesis (S. aureus)"/>
            <pathway-xref db="Reactome" id="R-DME-450520" name="HuR (ELAVL1) binds and stabilizes mRNA"/>
            <pathway-xref db="MetaCyc" id="PWY-5793" name="maysin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-380320" name="Recruitment of NuMA to mitotic centrosomes"/>
            <pathway-xref db="Reactome" id="R-MMU-428890" name="Role of ABL in ROBO-SLIT signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-68877" name="Mitotic Prometaphase"/>
            <pathway-xref db="MetaCyc" id="PWY-6401" name="hispidol and hispidol 4'-O-beta-D-glucoside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SPO-8949613" name="Cristae formation"/>
            <pathway-xref db="Reactome" id="R-MMU-983231" name="Factors involved in megakaryocyte development and platelet production"/>
            <pathway-xref db="Reactome" id="R-HSA-165054" name="Rev-mediated nuclear export of HIV RNA"/>
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            <pathway-xref db="Reactome" id="R-CEL-438066" name="Unblocking of NMDA receptors, glutamate binding and activation"/>
            <pathway-xref db="Reactome" id="R-HSA-5686938" name="Regulation of TLR by endogenous ligand"/>
            <pathway-xref db="Reactome" id="R-MMU-168181" name="Toll Like Receptor 7/8 (TLR7/8) Cascade"/>
            <pathway-xref db="MetaCyc" id="PWY-7697" name="geranyl beta-primeveroside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-198203" name="PI3K/AKT activation"/>
            <pathway-xref db="Reactome" id="R-HSA-9665244" name="Resistance of ERBB2 KD mutants to sapitinib"/>
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            <pathway-xref db="Reactome" id="R-HSA-8876493" name="InlA-mediated entry of Listeria monocytogenes into host cells"/>
            <pathway-xref db="Reactome" id="R-DRE-6804115" name="TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"/>
            <pathway-xref db="MetaCyc" id="PWY-7885" name="phosphatidylinositol mannoside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9660537" name="Signaling by MRAS-complex mutants"/>
            <pathway-xref db="Reactome" id="R-HSA-9707616" name="Heme signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-6320" name="phaselate biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-MMU-5686938" name="Regulation of TLR by endogenous ligand"/>
            <pathway-xref db="Reactome" id="R-GGA-9026527" name="Activated NTRK2 signals through PLCG1"/>
            <pathway-xref db="MetaCyc" id="PWY-2021" name="indole-3-acetate inactivation IV"/>
            <pathway-xref db="Reactome" id="R-HSA-140837" name="Intrinsic Pathway of Fibrin Clot Formation"/>
            <pathway-xref db="MetaCyc" id="PWY-5975" name="furaneol and mesifurane biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-214863" name="Adaptor protein complex binds to TL receptor at the plasma membrane"/>
            <pathway-xref db="MetaCyc" id="PWY-8122" name="mycofactocin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-5663220" name="RHO GTPases Activate Formins"/>
            <pathway-xref db="MetaCyc" id="PWY-7415" name="tylosin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-5602571" name="TRAF3 deficiency - HSE"/>
            <pathway-xref db="MetaCyc" id="PWY-7254" name="TCA cycle VII (acetate-producers)"/>
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            <pathway-xref db="Reactome" id="R-RNO-844456" name="The NLRP3 inflammasome"/>
            <pathway-xref db="Reactome" id="R-HSA-5663220" name="RHO GTPases Activate Formins"/>
            <pathway-xref db="Reactome" id="R-MMU-76009" name="Platelet Aggregation (Plug Formation)"/>
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            <pathway-xref db="Reactome" id="R-MMU-177929" name="Signaling by EGFR"/>
            <pathway-xref db="MetaCyc" id="PWY-1921" name="indole-3-acetate activation II"/>
            <pathway-xref db="MetaCyc" id="PWY-7186" name="superpathway of scopolin and esculin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DRE-5673000" name="RAF activation"/>
            <pathway-xref db="MetaCyc" id="PWY-8082" name="glycine lipid biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-8220" name="Escherichia coli serotype O:117 O antigen biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-HSA-199418" name="Negative regulation of the PI3K/AKT network"/>
            <pathway-xref db="MetaCyc" id="PWY-7058" name="esculetin modification"/>
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            <pathway-xref db="MetaCyc" id="PWY-7445" name="luteolin triglucuronide degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-444821" name="Relaxin receptors"/>
            <pathway-xref db="MetaCyc" id="PWY-5903" name="bacillibactin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-6804115" name="TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"/>
            <pathway-xref db="MetaCyc" id="PWY-7689" name="8-O-methylfusarubin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-438066" name="Unblocking of NMDA receptors, glutamate binding and activation"/>
            <pathway-xref db="MetaCyc" id="PWY-5338" name="galactosylcyclitol biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6279" name="myxol-2' fucoside biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-6239" name="luteolin glycosides biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-209442" name="Formation of the trans-membrane 'signalling complex'"/>
            <pathway-xref db="Reactome" id="R-RNO-9013423" name="RAC3 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-170984" name="ARMS-mediated activation"/>
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            <pathway-xref db="Reactome" id="R-CEL-8941413" name="Events associated with phagocytolytic activity of PMN cells"/>
            <pathway-xref db="MetaCyc" id="PWY-7726" name="(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)"/>
            <pathway-xref db="Reactome" id="R-SCE-6798695" name="Neutrophil degranulation"/>
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            <pathway-xref db="MetaCyc" id="PWY-6546" name="brassinosteroids inactivation"/>
            <pathway-xref db="Reactome" id="R-BTA-450520" name="HuR (ELAVL1) binds and stabilizes mRNA"/>
            <pathway-xref db="MetaCyc" id="PWY-7280" name="ternatin C3 biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-5673000" name="RAF activation"/>
            <pathway-xref db="Reactome" id="R-HSA-9665249" name="Resistance of ERBB2 KD mutants to afatinib"/>
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            <pathway-xref db="Reactome" id="R-MMU-1679131" name="Trafficking and processing of endosomal TLR"/>
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            <pathway-xref db="Reactome" id="R-GGA-2022857" name="Keratan sulfate degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7954" name="tabtoxinine-beta-lactam biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-6807004" name="Negative regulation of MET activity"/>
            <pathway-xref db="MetaCyc" id="PWY-8221" name="Escherichia coli serotype O:111/Salmonella enterica serotype O:35 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-5673000" name="RAF activation"/>
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            <pathway-xref db="Reactome" id="R-DDI-3295583" name="TRP channels"/>
            <pathway-xref db="MetaCyc" id="PWY-7352" name="daunorubicin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-214862" name="Activated PLL kinase is autophosphorylated in the TL receptor 'signalling complex'"/>
            <pathway-xref db="Reactome" id="R-MMU-9034793" name="Activated NTRK3 signals through PLCG1"/>
            <pathway-xref db="Reactome" id="R-HSA-2022857" name="Keratan sulfate degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-936440" name="Negative regulators of DDX58/IFIH1 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-9696270" name="RND2 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-8230" name="Salmonella enterica serotype O:13 O antigen biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-2681" name="trans-zeatin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8211" name="Escherichia coli serotype O:7 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-159230" name="Transport of the SLBP Dependant Mature mRNA"/>
            <pathway-xref db="MetaCyc" id="PWY-7449" name="acylated cyanidin galactoside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9665233" name="Resistance of ERBB2 KD mutants to trastuzumab"/>
            <pathway-xref db="Reactome" id="R-MMU-159230" name="Transport of the SLBP Dependant Mature mRNA"/>
            <pathway-xref db="Reactome" id="R-HSA-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-HSA-936440" name="Negative regulators of DDX58/IFIH1 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-8116" name="ochratoxin A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-975110" name="TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling"/>
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            <pathway-xref db="Reactome" id="R-HSA-5602498" name="MyD88 deficiency (TLR2/4)"/>
            <pathway-xref db="Reactome" id="R-SPO-6798695" name="Neutrophil degranulation"/>
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            <pathway-xref db="Reactome" id="R-DRE-9696270" name="RND2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-5602415" name="UNC93B1 deficiency - HSE"/>
            <pathway-xref db="Reactome" id="R-HSA-2500257" name="Resolution of Sister Chromatid Cohesion"/>
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            <pathway-xref db="Reactome" id="R-MMU-9013404" name="RAC2 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-5129" name="sphingolipid biosynthesis (plants)"/>
            <pathway-xref db="Reactome" id="R-HSA-9673221" name="Defective F9 activation"/>
            <pathway-xref db="MetaCyc" id="PWY-7461" name="hydroxycinnamate sugar acid ester biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SCE-9696270" name="RND2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-193634" name="Axonal growth inhibition (RHOA activation)"/>
            <pathway-xref db="Reactome" id="R-HSA-168179" name="Toll Like Receptor TLR1:TLR2 Cascade"/>
            <pathway-xref db="MetaCyc" id="PWY-7945" name="2,2'-bis-(4-hydroxy-3-methybut-2-enyl)-beta,beta-carotene monoglucoside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-450321" name="JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1"/>
            <pathway-xref db="MetaCyc" id="PWY-7653" name="griseofulvin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DDI-381676" name="Glucagon-like Peptide-1 (GLP1) regulates insulin secretion"/>
            <pathway-xref db="MetaCyc" id="PWY-8012" name="mupirocin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9013424" name="RHOV GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-4801" name="aloesone biosynthesis I"/>
            <pathway-xref db="Reactome" id="R-HSA-167021" name="PLC-gamma1 signalling"/>
            <pathway-xref db="MetaCyc" id="PWY-7171" name="flavonol acylglucoside biosynthesis II - isorhamnetin derivatives"/>
            <pathway-xref db="Reactome" id="R-SCE-9615933" name="Postmitotic nuclear pore complex (NPC) reformation"/>
            <pathway-xref db="Reactome" id="R-RNO-187042" name="TRKA activation by NGF"/>
            <pathway-xref db="MetaCyc" id="PWY-5094" name="naringenin glycoside biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-CFA-2022870" name="Chondroitin sulfate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-1461957" name="Beta defensins"/>
            <pathway-xref db="MetaCyc" id="PWY-7679" name="anthocyanidin acylglucoside and acylsambubioside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9652282" name="Drug-mediated inhibition of ERBB2 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-6958" name="icosapentaenoate biosynthesis I (lower eukaryotes)"/>
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            <pathway-xref db="Reactome" id="R-XTR-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-DDI-1632852" name="Macroautophagy"/>
            <pathway-xref db="Reactome" id="R-HSA-373752" name="Netrin-1 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-166020" name="Transfer of LPS from LBP carrier to CD14"/>
            <pathway-xref db="MetaCyc" id="PWY-4421" name="curcumin glucoside biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-DRE-380320" name="Recruitment of NuMA to mitotic centrosomes"/>
            <pathway-xref db="MetaCyc" id="PWY-5475" name="pentagalloylglucose biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7922" name="protein O-mannosylation II (mammals, core M1 and core M2)"/>
            <pathway-xref db="Reactome" id="R-RNO-381426" name="Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"/>
            <pathway-xref db="Reactome" id="R-DRE-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7688" name="dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9634285" name="Constitutive Signaling by Overexpressed ERBB2"/>
            <pathway-xref db="MetaCyc" id="PWY-8226" name="Escherichia coli serotype O:152 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-5223345" name="Miscellaneous transport and binding events"/>
            <pathway-xref db="MetaCyc" id="PWY-7713" name="nivalenol biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7412" name="mycinamicin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-141444" name="Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"/>
            <pathway-xref db="MetaCyc" id="PWY-7669" name="equisetin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-380259" name="Loss of Nlp from mitotic centrosomes"/>
            <pathway-xref db="Reactome" id="R-SCE-3108232" name="SUMO E3 ligases SUMOylate target proteins"/>
            <pathway-xref db="Reactome" id="R-HSA-8985586" name="SLIT2:ROBO1 increases RHOA activity"/>
            <pathway-xref db="MetaCyc" id="PWY-7470" name="phosphatidylcholine biosynthesis VII"/>
            <pathway-xref db="Reactome" id="R-MMU-5654687" name="Downstream signaling of activated FGFR1"/>
            <pathway-xref db="MetaCyc" id="PWY-5342" name="ajugose biosynthesis I (galactinol-dependent)"/>
            <pathway-xref db="Reactome" id="R-DDI-5675482" name="Regulation of necroptotic cell death"/>
            <pathway-xref db="MetaCyc" id="PWY-6944" name="androstenedione degradation I (aerobic)"/>
            <pathway-xref db="MetaCyc" id="PWY-7561" name="tenellin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SPO-199418" name="Negative regulation of the PI3K/AKT network"/>
            <pathway-xref db="MetaCyc" id="PWY-8209" name="Escherichia coli serotype O:15 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-214869" name="Phosphorylated CACT, DL and DIF homodimers dissociate from the TL receptor 'signalling complex'"/>
            <pathway-xref db="MetaCyc" id="PWY-7884" name="lipoprotein posttranslational modification"/>
            <pathway-xref db="MetaCyc" id="PWY-7659" name="viridicatumtoxin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-84" name="resveratrol biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-140837" name="Intrinsic Pathway of Fibrin Clot Formation"/>
            <pathway-xref db="MetaCyc" id="PWY-7250" name="[2Fe-2S] iron-sulfur cluster biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-2243919" name="Crosslinking of collagen fibrils"/>
            <pathway-xref db="Reactome" id="R-HSA-168164" name="Toll Like Receptor 3 (TLR3) Cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-166016" name="Toll Like Receptor 4 (TLR4) Cascade"/>
            <pathway-xref db="Reactome" id="R-MMU-445989" name="TAK1 activates NFkB by phosphorylation and activation of IKKs complex"/>
            <pathway-xref db="MetaCyc" id="PWY-7728" name="(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)"/>
            <pathway-xref db="MetaCyc" id="PWY-8250" name="Escherichia coli serotype O:9 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-140534" name="Caspase activation via Death Receptors in the presence of ligand"/>
            <pathway-xref db="Reactome" id="R-CEL-3108232" name="SUMO E3 ligases SUMOylate target proteins"/>
            <pathway-xref db="Reactome" id="R-DME-159231" name="Transport of Mature mRNA Derived from an Intronless Transcript"/>
            <pathway-xref db="MetaCyc" id="PWY-6655" name="xanthan biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-209968" name="Thyroxine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8222" name="Escherichia coli serotype O:128 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-438066" name="Unblocking of NMDA receptors, glutamate binding and activation"/>
            <pathway-xref db="MetaCyc" id="PWY-5381" name="NAD salvage (plants)"/>
            <pathway-xref db="MetaCyc" id="PWY-6010" name="apigenin glycosides biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7746" name="mycobacterial sulfolipid biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-187024" name="NGF-independant TRKA activation"/>
            <pathway-xref db="MetaCyc" id="PWY-8151" name="cholesterol degradation to androstenedione III (anaerobic)"/>
            <pathway-xref db="Reactome" id="R-HSA-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-166020" name="Transfer of LPS from LBP carrier to CD14"/>
            <pathway-xref db="MetaCyc" id="PWY-7002" name="4-hydroxyacetophenone degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7053" name="docosahexaenoate biosynthesis I (lower eukaryotes)"/>
            <pathway-xref db="Reactome" id="R-MMU-166016" name="Toll Like Receptor 4 (TLR4) Cascade"/>
            <pathway-xref db="Reactome" id="R-RNO-5654687" name="Downstream signaling of activated FGFR1"/>
            <pathway-xref db="Reactome" id="R-HSA-844456" name="The NLRP3 inflammasome"/>
            <pathway-xref db="Reactome" id="R-HSA-170968" name="Frs2-mediated activation"/>
            <pathway-xref db="Reactome" id="R-MMU-1227986" name="Signaling by ERBB2"/>
            <pathway-xref db="Reactome" id="R-MMU-114608" name="Platelet degranulation"/>
            <pathway-xref db="MetaCyc" id="PWY-8208" name="Salmonella enterica serotype O:6,7 O antigen biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7487" name="(+)-secoisolariciresinol diglucoside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-159231" name="Transport of Mature mRNA Derived from an Intronless Transcript"/>
            <pathway-xref db="Reactome" id="R-HSA-450302" name="activated TAK1 mediates p38 MAPK activation"/>
            <pathway-xref db="Reactome" id="R-BTA-2022854" name="Keratan sulfate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8243" name="colanic acid (Escherichia coli K12) biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-844456" name="The NLRP3 inflammasome"/>
            <pathway-xref db="Reactome" id="R-HSA-198203" name="PI3K/AKT activation"/>
            <pathway-xref db="Reactome" id="R-HSA-114608" name="Platelet degranulation"/>
            <pathway-xref db="Reactome" id="R-MMU-199418" name="Negative regulation of the PI3K/AKT network"/>
            <pathway-xref db="MetaCyc" id="PWY-7816" name="poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)"/>
            <pathway-xref db="Reactome" id="R-HSA-428540" name="Activation of RAC1"/>
            <pathway-xref db="MetaCyc" id="PWY-8045" name="cylindrospermopsin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-HSA-168142" name="Toll Like Receptor 10 (TLR10) Cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-198745" name="Signalling to STAT3"/>
            <pathway-xref db="Reactome" id="R-MMU-450302" name="activated TAK1 mediates p38 MAPK activation"/>
            <pathway-xref db="MetaCyc" id="PWY-83" name="monolignol glucosides biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7719" name="CMP-diacetamido-8-epilegionaminic acid biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7690" name="holomycin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5392" name="reductive TCA cycle II"/>
            <pathway-xref db="Reactome" id="R-BTA-5223345" name="Miscellaneous transport and binding events"/>
            <pathway-xref db="Reactome" id="R-HSA-9648025" name="EML4 and NUDC in mitotic spindle formation"/>
            <pathway-xref db="MetaCyc" id="PWY-5380" name="A series fagopyritols biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5660" name="taxol biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-2024101" name="CS/DS degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-430116" name="GP1b-IX-V activation signalling"/>
            <pathway-xref db="Reactome" id="R-HSA-5689901" name="Metalloprotease DUBs"/>
            <pathway-xref db="MetaCyc" id="PWY-7696" name="citreoisocoumarin and bikisocoumarin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7342" name="superpathway of nicotine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9013026" name="RHOB GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-6797" name="6-hydroxymethyl-dihydropterin diphosphate biosynthesis II (Methanocaldococcus)"/>
            <pathway-xref db="Reactome" id="R-BTA-3000178" name="ECM proteoglycans"/>
            <pathway-xref db="MetaCyc" id="PWY-7740" name="beta-D-mannosyl phosphomycoketide biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-937072" name="TRAF6-mediated induction of TAK1 complex within TLR4 complex"/>
            <pathway-xref db="Reactome" id="R-HSA-187706" name="Signalling to p38 via RIT and RIN"/>
            <pathway-xref db="Reactome" id="R-CEL-8951664" name="Neddylation"/>
            <pathway-xref db="MetaCyc" id="PWY-8233" name="Escherichia coli serotype O:169 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DDI-1660499" name="Synthesis of PIPs at the plasma membrane"/>
            <pathway-xref db="MetaCyc" id="PWY-7592" name="arachidonate biosynthesis III (6-desaturase, mammals)"/>
            <pathway-xref db="MetaCyc" id="PWY-8217" name="Escherichia coli serotype O:55/Salmonella enterica serotype O:50 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-8849932" name="Synaptic adhesion-like molecules"/>
            <pathway-xref db="MetaCyc" id="PWY-8206" name="Salmonella enterica serotype O:18 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9660821" name="ADORA2B mediated anti-inflammatory cytokines production"/>
            <pathway-xref db="MetaCyc" id="PWY-8152" name="androstenedione degradation II (anaerobic)"/>
            <pathway-xref db="MetaCyc" id="PWY-361" name="phenylpropanoid biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9664565" name="Signaling by ERBB2 KD Mutants"/>
            <pathway-xref db="Reactome" id="R-HSA-1971475" name="A tetrasaccharide linker sequence is required for GAG synthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7570" name="blasticidin S biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-5617472" name="Activation of anterior HOX genes in hindbrain development during early embryogenesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5984" name="rifamycin B biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6442" name="spermidine hydroxycinnamic acid conjugates biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SPO-159227" name="Transport of the SLBP independent Mature mRNA"/>
            <pathway-xref db="MetaCyc" id="PWY-8253" name="Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7921" name="protein O-mannosylation I (yeast)"/>
            <pathway-xref db="MetaCyc" id="PWY-7530" name="Escherichia coli serotype O:104 O antigen biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7491" name="podophyllotoxin glucosides metabolism"/>
            <pathway-xref db="Reactome" id="R-HSA-9609736" name="Assembly and cell surface presentation of NMDA receptors"/>
            <pathway-xref db="Reactome" id="R-RNO-450520" name="HuR (ELAVL1) binds and stabilizes mRNA"/>
            <pathway-xref db="MetaCyc" id="PWY-7463" name="N-methylanthraniloyl-beta-D-glucopyranose biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7166" name="kaempferide triglycoside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-5689896" name="Ovarian tumor domain proteases"/>
            <pathway-xref db="Reactome" id="R-MMU-163125" name="Post-translational modification: synthesis of GPI-anchored proteins"/>
            <pathway-xref db="MetaCyc" id="PWY-6673" name="caffeoylglucarate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9707564" name="Cytoprotection by HMOX1"/>
            <pathway-xref db="MetaCyc" id="PWY-6799" name="fatty acid biosynthesis initiation (plant mitochondria)"/>
            <pathway-xref db="MetaCyc" id="PWY-7658" name="protein N-glycosylation (Methanococcus voltae)"/>
            <pathway-xref db="Reactome" id="R-RNO-2022870" name="Chondroitin sulfate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9603381" name="Activated NTRK3 signals through PI3K"/>
            <pathway-xref db="Reactome" id="R-HSA-9034013" name="NTF3 activates NTRK3 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-6804115" name="TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"/>
            <pathway-xref db="MetaCyc" id="PWY-7706" name="dapdiamides biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7318" name="dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7986" name="anguibactin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9696270" name="RND2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DME-214874" name="PLL kinase binds to TUB in the TL receptor 'signalling complex'"/>
            <pathway-xref db="Reactome" id="R-HSA-9696264" name="RND3 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-1981" name="indole-3-acetate inactivation III"/>
            <pathway-xref db="Reactome" id="R-RNO-9028731" name="Activated NTRK2 signals through FRS2 and FRS3"/>
            <pathway-xref db="MetaCyc" id="PWY-7407" name="aurachin A, B, C and D biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-141444" name="Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"/>
            <pathway-xref db="Reactome" id="R-HSA-9013149" name="RAC1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-9615933" name="Postmitotic nuclear pore complex (NPC) reformation"/>
            <pathway-xref db="Reactome" id="R-HSA-9013423" name="RAC3 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-6310" name="aloesone biosynthesis II"/>
            <pathway-xref db="Reactome" id="R-SCE-199418" name="Negative regulation of the PI3K/AKT network"/>
            <pathway-xref db="Reactome" id="R-HSA-428542" name="Regulation of commissural axon pathfinding by SLIT and ROBO"/>
            <pathway-xref db="Reactome" id="R-DME-4615885" name="SUMOylation of DNA replication proteins"/>
            <pathway-xref db="MetaCyc" id="PWY-7191" name="kaempferol diglycoside biosynthesis (pollen-specific)"/>
            <pathway-xref db="MetaCyc" id="PWY-7815" name="poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)"/>
            <pathway-xref db="Reactome" id="R-RNO-159236" name="Transport of Mature mRNA derived from an Intron-Containing Transcript"/>
            <pathway-xref db="MetaCyc" id="PWY-5794" name="malonate degradation I (biotin-independent)"/>
            <pathway-xref db="MetaCyc" id="PWY-2901" name="cytokinins 9-N-glucoside biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7129" name="quercetin glucoside biosynthesis (Allium)"/>
            <pathway-xref db="Reactome" id="R-HSA-9020702" name="Interleukin-1 signaling"/>
            <pathway-xref db="Reactome" id="R-DRE-380259" name="Loss of Nlp from mitotic centrosomes"/>
            <pathway-xref db="MetaCyc" id="PWY-7712" name="deoxynivalenol biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-193634" name="Axonal growth inhibition (RHOA activation)"/>
            <pathway-xref db="Reactome" id="R-MMU-6794361" name="Neurexins and neuroligins"/>
            <pathway-xref db="MetaCyc" id="PWY-5466" name="matairesinol biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5461" name="betanidin degradation"/>
            <pathway-xref db="Reactome" id="R-SPO-163210" name="Formation of ATP by chemiosmotic coupling"/>
            <pathway-xref db="Reactome" id="R-SCE-5223345" name="Miscellaneous transport and binding events"/>
            <pathway-xref db="Reactome" id="R-HSA-6803207" name="TP53 Regulates Transcription of Caspase Activators and Caspases"/>
            <pathway-xref db="Reactome" id="R-HSA-4615885" name="SUMOylation of DNA replication proteins"/>
            <pathway-xref db="MetaCyc" id="PWY-7382" name="lipoate biosynthesis and incorporation IV (yeast)"/>
            <pathway-xref db="MetaCyc" id="PWY-8035" name="streptovaricin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-6803207" name="TP53 Regulates Transcription of Caspase Activators and Caspases"/>
            <pathway-xref db="MetaCyc" id="PWY-7583" name="arachidonate biosynthesis II (bacteria)"/>
            <pathway-xref db="MetaCyc" id="PWY-7460" name="2-O-acetyl-3-O-trans-coutarate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5310" name="superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)"/>
            <pathway-xref db="Reactome" id="R-HSA-6807004" name="Negative regulation of MET activity"/>
            <pathway-xref db="Reactome" id="R-HSA-9032759" name="NTRK2 activates RAC1"/>
            <pathway-xref db="Reactome" id="R-HSA-877300" name="Interferon gamma signaling"/>
            <pathway-xref db="Reactome" id="R-DDI-9013149" name="RAC1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DME-9013406" name="RHOQ GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-8863795" name="Downregulation of ERBB2 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-8051" name="anandamide biosynthesis I"/>
            <pathway-xref db="Reactome" id="R-HSA-75892" name="Platelet Adhesion to exposed collagen"/>
            <pathway-xref db="Reactome" id="R-MMU-4615885" name="SUMOylation of DNA replication proteins"/>
            <pathway-xref db="Reactome" id="R-MMU-8857538" name="PTK6 promotes HIF1A stabilization"/>
            <pathway-xref db="Reactome" id="R-HSA-9620244" name="Long-term potentiation"/>
            <pathway-xref db="Reactome" id="R-RNO-444821" name="Relaxin receptors"/>
            <pathway-xref db="Reactome" id="R-HSA-3656225" name="Defective CHST6 causes MCDC1"/>
            <pathway-xref db="Reactome" id="R-SPO-9696270" name="RND2 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-641" name="proanthocyanidins biosynthesis from flavanols"/>
            <pathway-xref db="Reactome" id="R-HSA-8875360" name="InlB-mediated entry of Listeria monocytogenes into host cell"/>
            <pathway-xref db="Reactome" id="R-HSA-1606341" name="IRF3 mediated activation of type 1 IFN"/>
            <pathway-xref db="Reactome" id="R-HSA-8863795" name="Downregulation of ERBB2 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-8231" name="Escherichia coli serotype O:127 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-167044" name="Signalling to RAS"/>
            <pathway-xref db="Reactome" id="R-RNO-438066" name="Unblocking of NMDA receptors, glutamate binding and activation"/>
            <pathway-xref db="Reactome" id="R-MMU-9013408" name="RHOG GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-7820" name="teichuronic acid biosynthesis (B. subtilis 168)"/>
            <pathway-xref db="Reactome" id="R-MMU-6807004" name="Negative regulation of MET activity"/>
            <pathway-xref db="Reactome" id="R-HSA-9603505" name="NTRK3 as a dependence receptor"/>
            <pathway-xref db="Reactome" id="R-MMU-187042" name="TRKA activation by NGF"/>
            <pathway-xref db="Reactome" id="R-HSA-8857538" name="PTK6 promotes HIF1A stabilization"/>
            <pathway-xref db="Reactome" id="R-HSA-3595172" name="Defective CHST3 causes SEDCJD"/>
            <pathway-xref db="Reactome" id="R-RNO-8849932" name="Synaptic adhesion-like molecules"/>
            <pathway-xref db="Reactome" id="R-HSA-9665251" name="Resistance of ERBB2 KD mutants to lapatinib"/>
            <pathway-xref db="MetaCyc" id="PWY-81" name="toluene degradation to benzoyl-CoA (anaerobic)"/>
            <pathway-xref db="MetaCyc" id="PWY-8218" name="Escherichia coli serotype O:56 O antigen biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7532" name="acetylaszonalenin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5835" name="geranyl acetate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6728" name="methylaspartate cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-6036" name="cardenolide glucosides biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-1839117" name="Signaling by cytosolic FGFR1 fusion mutants"/>
            <pathway-xref db="Reactome" id="R-MMU-2022870" name="Chondroitin sulfate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CFA-3000178" name="ECM proteoglycans"/>
            <pathway-xref db="MetaCyc" id="PWY-8219" name="Escherichia coli serotype O:107 O antigen biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5397" name="crocetin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9665348" name="Signaling by ERBB2 ECD mutants"/>
            <pathway-xref db="MetaCyc" id="PWY-7671" name="saframycin A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-5689901" name="Metalloprotease DUBs"/>
            <pathway-xref db="Reactome" id="R-HSA-9013408" name="RHOG GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-6658" name="acetan biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7693" name="guadinomine B biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-936964" name="Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon"/>
            <pathway-xref db="Reactome" id="R-HSA-9665246" name="Resistance of ERBB2 KD mutants to neratinib"/>
            <pathway-xref db="Reactome" id="R-HSA-844455" name="The NLRP1 inflammasome"/>
            <pathway-xref db="MetaCyc" id="PWY-8166" name="emodin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-375281" name="Hormone ligand-binding receptors"/>
            <pathway-xref db="Reactome" id="R-HSA-381426" name="Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"/>
            <pathway-xref db="Reactome" id="R-BTA-2022923" name="Dermatan sulfate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6502" name="8-oxo-(d)GTP detoxification I"/>
            <pathway-xref db="Reactome" id="R-DME-72163" name="mRNA Splicing - Major Pathway"/>
            <pathway-xref db="MetaCyc" id="PWY-7071" name="steviol glucoside biosynthesis (rebaudioside A biosynthesis)"/>
            <pathway-xref db="MetaCyc" id="PWY-5343" name="ajugose biosynthesis II (galactinol-independent)"/>
            <pathway-xref db="MetaCyc" id="PWY-7989" name="acinetoferrin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7677" name="rosamicin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7261" name="anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)"/>
            <pathway-xref db="Reactome" id="R-HSA-9032500" name="Activated NTRK2 signals through FYN"/>
            <pathway-xref db="Reactome" id="R-HSA-9665250" name="Resistance of ERBB2 KD mutants to AEE788"/>
            <pathway-xref db="MetaCyc" id="PWY-8248" name="lipid A-core biosynthesis (P. gingivalis)"/>
            <pathway-xref db="MetaCyc" id="PWY-7702" name="sch210971 and sch210972 biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-5682910" name="LGI-ADAM interactions"/>
            <pathway-xref db="MetaCyc" id="PWY-7253" name="apigeninidin 5-O-glucoside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9028335" name="Activated NTRK2 signals through PI3K"/>
            <pathway-xref db="Reactome" id="R-CFA-109704" name="PI3K Cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-9013148" name="CDC42 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-6558" name="heparan sulfate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-168176" name="Toll Like Receptor 5 (TLR5) Cascade"/>
            <pathway-xref db="MetaCyc" id="PWY-5690" name="TCA cycle II (plants and fungi)"/>
            <pathway-xref db="Reactome" id="R-MMU-75892" name="Platelet Adhesion to exposed collagen"/>
            <pathway-xref db="Reactome" id="R-HSA-8950505" name="Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"/>
            <pathway-xref db="MetaCyc" id="PWY-6056" name="dimethylsulfoniopropanoate degradation II (cleavage)"/>
            <pathway-xref db="Reactome" id="R-HSA-168928" name="DDX58/IFIH1-mediated induction of interferon-alpha/beta"/>
            <pathway-xref db="Reactome" id="R-HSA-166058" name="MyD88:MAL(TIRAP) cascade initiated on plasma membrane"/>
            <pathway-xref db="MetaCyc" id="PWY-7452" name="cyanidin dimalonylglucoside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-168138" name="Toll Like Receptor 9 (TLR9) Cascade"/>
            <pathway-xref db="MetaCyc" id="PWY-8038" name="naphthomycin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7055" name="daphnetin modification"/>
            <pathway-xref db="MetaCyc" id="PWY-7737" name="thiocoraline biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-9013148" name="CDC42 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-5759" name="saponin biosynthesis III"/>
            <pathway-xref db="MetaCyc" id="PWY-7458" name="violdelphin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7672" name="fusaric acid biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7529" name="CMP-N-acetyl-7-O-acetylneuraminate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-8985801" name="Regulation of cortical dendrite branching"/>
            <pathway-xref db="Reactome" id="R-HSA-9662360" name="Sensory processing of sound by inner hair cells of the cochlea"/>
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            <pathway-xref db="Reactome" id="R-HSA-4641263" name="Regulation of FZD by ubiquitination"/>
            <pathway-xref db="MetaCyc" id="PWY-5797" name="indole-3-acetate inactivation VI"/>
            <pathway-xref db="MetaCyc" id="PWY-5679" name="clavulanate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9013409" name="RHOJ GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-7511" name="protein ubiquitination"/>
            <pathway-xref db="MetaCyc" id="PWY-8075" name="(Kdo)2-lipid A biosynthesis (P. putida)"/>
            <pathway-xref db="MetaCyc" id="PWY-7821" name="tunicamycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-450520" name="HuR (ELAVL1) binds and stabilizes mRNA"/>
            <pathway-xref db="Reactome" id="R-DME-159230" name="Transport of the SLBP Dependant Mature mRNA"/>
            <pathway-xref db="MetaCyc" id="PWY-1961" name="indole-3-acetate inactivation I"/>
            <pathway-xref db="Reactome" id="R-HSA-428890" name="Role of ABL in ROBO-SLIT signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-4641263" name="Regulation of FZD by ubiquitination"/>
            <pathway-xref db="Reactome" id="R-MMU-9032759" name="NTRK2 activates RAC1"/>
            <pathway-xref db="Reactome" id="R-RNO-936440" name="Negative regulators of DDX58/IFIH1 signaling"/>
            <pathway-xref db="Reactome" id="R-DDI-1169092" name="Activation of RAS in B cells"/>
            <pathway-xref db="Reactome" id="R-RNO-163125" name="Post-translational modification: synthesis of GPI-anchored proteins"/>
            <pathway-xref db="Reactome" id="R-MMU-3000178" name="ECM proteoglycans"/>
            <pathway-xref db="Reactome" id="R-RNO-9034793" name="Activated NTRK3 signals through PLCG1"/>
            <pathway-xref db="MetaCyc" id="PWY-7265" name="lampranthin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-198203" name="PI3K/AKT activation"/>
            <pathway-xref db="Reactome" id="R-HSA-9013406" name="RHOQ GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-7818" name="type IV lipoteichoic acid biosynthesis (S. pneumoniae)"/>
            <pathway-xref db="MetaCyc" id="PWY-6385" name="peptidoglycan biosynthesis III (mycobacteria)"/>
            <pathway-xref db="Reactome" id="R-GGA-517856" name="TLR2 subfamily cascade"/>
            <pathway-xref db="MetaCyc" id="PWY-7624" name="nystatin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6397" name="mycolyl-arabinogalactan-peptidoglycan complex biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-446388" name="Regulation of cytoskeletal remodeling and cell spreading by IPP complex components"/>
            <pathway-xref db="MetaCyc" id="PWY-7601" name="arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)"/>
            <pathway-xref db="MetaCyc" id="PWY-8249" name="xanthommatin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-2467813" name="Separation of Sister Chromatids"/>
            <pathway-xref db="Reactome" id="R-DRE-8854050" name="FBXL7 down-regulates AURKA during mitotic entry and in early mitosis"/>
            <pathway-xref db="Reactome" id="R-RNO-8951664" name="Neddylation"/>
            <pathway-xref db="Reactome" id="R-DME-214842" name="DL and DIF homodimers bind to TUB and phosphorylated PLL in the TL receptor 'signalling complex'"/>
            <pathway-xref db="Reactome" id="R-HSA-2467813" name="Separation of Sister Chromatids"/>
            <pathway-xref db="MetaCyc" id="PWY-8212" name="Escherichia coli serotype O:8 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-8936459" name="RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"/>
            <pathway-xref db="MetaCyc" id="PWY-7983" name="pseudomonine biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-MMU-388844" name="Receptor-type tyrosine-protein phosphatases"/>
            <pathway-xref db="MetaCyc" id="PWY-5400" name="amaranthin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-8854518" name="AURKA Activation by TPX2"/>
            <pathway-xref db="Reactome" id="R-MMU-977606" name="Regulation of Complement cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-168181" name="Toll Like Receptor 7/8 (TLR7/8) Cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-9026527" name="Activated NTRK2 signals through PLCG1"/>
            <pathway-xref db="Reactome" id="R-MMU-170968" name="Frs2-mediated activation"/>
            <pathway-xref db="MetaCyc" id="PWY-6322" name="phosphinothricin tripeptide biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-CEL-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-DRE-9696264" name="RND3 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-5437" name="L-threonine degradation I"/>
            <pathway-xref db="MetaCyc" id="PWY-7474" name="avenacin A-2 biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-5379" name="B series fagopyritols biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-2562578" name="TRIF-mediated programmed cell death"/>
            <pathway-xref db="MetaCyc" id="PWY-7037" name="protein O-glycosylation (Neisseria)"/>
            <pathway-xref db="Reactome" id="R-HSA-2562578" name="TRIF-mediated programmed cell death"/>
            <pathway-xref db="Reactome" id="R-DDI-5621575" name="CD209 (DC-SIGN) signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-844455" name="The NLRP1 inflammasome"/>
            <pathway-xref db="Reactome" id="R-DME-376176" name="Signaling by ROBO receptors"/>
            <pathway-xref db="Reactome" id="R-MMU-159227" name="Transport of the SLBP independent Mature mRNA"/>
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            <pathway-xref db="MetaCyc" id="PWY-7172" name="flavonol acylglucoside biosynthesis III - quercetin derivatives"/>
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            <pathway-xref db="Reactome" id="R-GGA-451514" name="MyD88:TIRAP-dependent cascade initiated on plasma membrane"/>
            <pathway-xref db="MetaCyc" id="PWY-6032" name="digitoxigenin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DRE-8951664" name="Neddylation"/>
            <pathway-xref db="MetaCyc" id="PWY-7473" name="avenacin A-1 biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-6803207" name="TP53 Regulates Transcription of Caspase Activators and Caspases"/>
            <pathway-xref db="Reactome" id="R-GGA-388844" name="Receptor-type tyrosine-protein phosphatases"/>
            <pathway-xref db="Reactome" id="R-HSA-8854518" name="AURKA Activation by TPX2"/>
            <pathway-xref db="MetaCyc" id="PWY-7716" name="penicillin G and penicillin V biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DDI-1483248" name="Synthesis of PIPs at the ER membrane"/>
            <pathway-xref db="MetaCyc" id="PWY-7192" name="quercetin diglycoside biosynthesis (pollen-specific)"/>
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            <pathway-xref db="MetaCyc" id="PWY-6624" name="salicylate glucosides biosynthesis III"/>
            <pathway-xref db="Reactome" id="R-MMU-9013106" name="RHOC GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-216083" name="Integrin cell surface interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-2022923" name="Dermatan sulfate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-8941413" name="Events associated with phagocytolytic activity of PMN cells"/>
            <pathway-xref db="Reactome" id="R-DME-159236" name="Transport of Mature mRNA derived from an Intron-Containing Transcript"/>
            <pathway-xref db="Reactome" id="R-DDI-193648" name="NRAGE signals death through JNK"/>
            <pathway-xref db="Reactome" id="R-GGA-2022854" name="Keratan sulfate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-BTA-1971475" name="A tetrasaccharide linker sequence is required for GAG synthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-3656244" name="Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)"/>
            <pathway-xref db="MetaCyc" id="PWY-5473" name="hydroxycinnamic acid serotonin amides biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-109704" name="PI3K Cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-3134975" name="Regulation of innate immune responses to cytosolic DNA"/>
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            <pathway-xref db="MetaCyc" id="PWY-8289" name="dZTP biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-3270619" name="IRF3-mediated induction of type I IFN"/>
            <pathway-xref db="Reactome" id="R-DDI-354192" name="Integrin signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-975871" name="MyD88 cascade initiated on plasma membrane"/>
            <pathway-xref db="Reactome" id="R-MMU-3134975" name="Regulation of innate immune responses to cytosolic DNA"/>
            <pathway-xref db="MetaCyc" id="PWY-6378" name="putrebactin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DRE-8849932" name="Synaptic adhesion-like molecules"/>
            <pathway-xref db="Reactome" id="R-MMU-166020" name="Transfer of LPS from LBP carrier to CD14"/>
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            <pathway-xref db="Reactome" id="R-HSA-975163" name="IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation"/>
            <pathway-xref db="Reactome" id="R-RNO-9696264" name="RND3 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-7738" name="polyacyltrehalose biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-CFA-168138" name="Toll Like Receptor 9 (TLR9) Cascade"/>
            <pathway-xref db="Reactome" id="R-RNO-429947" name="Deadenylation of mRNA"/>
            <pathway-xref db="Reactome" id="R-DDI-392517" name="Rap1 signalling"/>
            <pathway-xref db="Reactome" id="R-HSA-2022870" name="Chondroitin sulfate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8058" name="2-deoxy-D-ribose degradation II"/>
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            <pathway-xref db="Reactome" id="R-HSA-9026519" name="Activated NTRK2 signals through RAS"/>
            <pathway-xref db="Reactome" id="R-MMU-9026527" name="Activated NTRK2 signals through PLCG1"/>
            <pathway-xref db="Reactome" id="R-MMU-380284" name="Loss of proteins required for interphase microtubule organization from the centrosome"/>
            <pathway-xref db="MetaCyc" id="PWY-5672" name="ginsenosides biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-6039" name="chlorogenic acid biosynthesis I"/>
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            <pathway-xref db="Reactome" id="R-DME-159227" name="Transport of the SLBP independent Mature mRNA"/>
            <pathway-xref db="Reactome" id="R-DME-388844" name="Receptor-type tyrosine-protein phosphatases"/>
            <pathway-xref db="MetaCyc" id="PWY-5936" name="xyloglucan biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-9028731" name="Activated NTRK2 signals through FRS2 and FRS3"/>
            <pathway-xref db="MetaCyc" id="PWY-8210" name="pyrrolomycin biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-HSA-9028731" name="Activated NTRK2 signals through FRS2 and FRS3"/>
            <pathway-xref db="MetaCyc" id="PWY-5292" name="vindoline, vindorosine and vinblastine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-3270619" name="IRF3-mediated induction of type I IFN"/>
            <pathway-xref db="MetaCyc" id="PWY-7367" name="phosphatidylcholine resynthesis via glycerophosphocholine"/>
            <pathway-xref db="Reactome" id="R-MMU-2022923" name="Dermatan sulfate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8039" name="mitomycin biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-7555" name="alpha-cyclopiazonate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-3000178" name="ECM proteoglycans"/>
            <pathway-xref db="Reactome" id="R-HSA-9013106" name="RHOC GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-7140" name="myricetin gentiobioside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-5673000" name="RAF activation"/>
            <pathway-xref db="MetaCyc" id="PWY-7735" name="echinomycin and triostin A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-2022854" name="Keratan sulfate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SPO-5223345" name="Miscellaneous transport and binding events"/>
            <pathway-xref db="MetaCyc" id="PWY-7621" name="autoinducer CAI-1 biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5994" name="palmitate biosynthesis I (type I fatty acid synthase)"/>
            <pathway-xref db="Reactome" id="R-CEL-159236" name="Transport of Mature mRNA derived from an Intron-Containing Transcript"/>
            <pathway-xref db="Reactome" id="R-RNO-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-8047" name="bryostatin biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-HSA-3560783" name="Defective B4GALT7 causes EDS, progeroid type"/>
            <pathway-xref db="MetaCyc" id="PWY-6948" name="sitosterol degradation to androstenedione"/>
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            <pathway-xref db="Reactome" id="R-CFA-2024101" name="CS/DS degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-5602680" name="MyD88 deficiency (TLR5)"/>
            <pathway-xref db="MetaCyc" id="PWY-6525" name="stellariose and mediose biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9665245" name="Resistance of ERBB2 KD mutants to tesevatinib"/>
            <pathway-xref db="Reactome" id="R-HSA-9013404" name="RAC2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DRE-450520" name="HuR (ELAVL1) binds and stabilizes mRNA"/>
            <pathway-xref db="MetaCyc" id="PWY-8241" name="Escherichia coli serotype O:71/Salmonella enterica serotype O:28ac O antigen biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-MMU-9010553" name="Regulation of expression of SLITs and ROBOs"/>
            <pathway-xref db="MetaCyc" id="PWY-8251" name="Escherichia coli serotype O:2 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-9026527" name="Activated NTRK2 signals through PLCG1"/>
            <pathway-xref db="Reactome" id="R-RNO-2024101" name="CS/DS degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-8985586" name="SLIT2:ROBO1 increases RHOA activity"/>
            <pathway-xref db="Reactome" id="R-DRE-2022854" name="Keratan sulfate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8133" name="succinoglycan biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-GGA-9028731" name="Activated NTRK2 signals through FRS2 and FRS3"/>
            <pathway-xref db="MetaCyc" id="PWY-7564" name="bacimethrin and bacimethrin pyrophosphate biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-GGA-433822" name="NFkB and MAPK activation mediated by TRAF6"/>
            <pathway-xref db="MetaCyc" id="PWY-8272" name="Escherichia coli serotype O:49 O antigen biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7137" name="quercetin gentiotetraside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-9013424" name="RHOV GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-6969" name="TCA cycle V (2-oxoglutarate synthase)"/>
            <pathway-xref db="Reactome" id="R-RNO-5686938" name="Regulation of TLR by endogenous ligand"/>
            <pathway-xref db="Reactome" id="R-MMU-2022857" name="Keratan sulfate degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-8252" name="Escherichia coli serotype O:50 O antigen biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8236" name="Salmonella enterica serotype O:39 O antigen biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-DRE-429947" name="Deadenylation of mRNA"/>
            <pathway-xref db="Reactome" id="R-HSA-9665686" name="Signaling by ERBB2 TMD/JMD mutants"/>
            <pathway-xref db="Reactome" id="R-MMU-2500257" name="Resolution of Sister Chromatid Cohesion"/>
            <pathway-xref db="Reactome" id="R-HSA-9034793" name="Activated NTRK3 signals through PLCG1"/>
            <pathway-xref db="Reactome" id="R-CEL-9615933" name="Postmitotic nuclear pore complex (NPC) reformation"/>
            <pathway-xref db="MetaCyc" id="PWY-7143" name="kaempferol gentiobioside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9013957" name="TLR3-mediated TICAM1-dependent programmed cell death"/>
            <pathway-xref db="MetaCyc" id="PWY-7384" name="anaerobic energy metabolism (invertebrates, mitochondrial)"/>
            <pathway-xref db="MetaCyc" id="PWY-7727" name="docosahexaenoate biosynthesis IV (4-desaturase, mammals)"/>
            <pathway-xref db="Reactome" id="R-HSA-8873719" name="RAB geranylgeranylation"/>
            <pathway-xref db="MetaCyc" id="PWY-6312" name="barbaloin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DDI-5674135" name="MAP2K and MAPK activation"/>
            <pathway-xref db="Reactome" id="R-HSA-216083" name="Integrin cell surface interactions"/>
            <pathway-xref db="MetaCyc" id="PWY-761" name="rhizobactin 1021 biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-1971475" name="A tetrasaccharide linker sequence is required for GAG synthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7673" name="fusarin C biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-209968" name="Thyroxine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7563" name="bassianin and desmethylbassianin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7214" name="baicalein degradation (hydrogen peroxide detoxification)"/>
            <pathway-xref db="MetaCyc" id="PWY-6672" name="cis-geranyl-CoA degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-9652282" name="Drug-mediated inhibition of ERBB2 signaling"/>
            <pathway-xref db="Reactome" id="R-SSC-168138" name="Toll Like Receptor 9 (TLR9) Cascade"/>
            <pathway-xref db="MetaCyc" id="PWY-7212" name="baicalein metabolism"/>
            <pathway-xref db="MetaCyc" id="PWY-6722" name="candicidin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-BTA-2022870" name="Chondroitin sulfate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-380259" name="Loss of Nlp from mitotic centrosomes"/>
            <pathway-xref db="Reactome" id="R-HSA-418555" name="G alpha (s) signalling events"/>
            <pathway-xref db="Reactome" id="R-DRE-5620912" name="Anchoring of the basal body to the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-DRE-9013406" name="RHOQ GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-1461957" name="Beta defensins"/>
            <pathway-xref db="MetaCyc" id="PWY-7468" name="benzoyl-beta-D-glucopyranose biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-5223345" name="Miscellaneous transport and binding events"/>
            <pathway-xref db="Reactome" id="R-HSA-444821" name="Relaxin receptors"/>
            <pathway-xref db="Reactome" id="R-HSA-168188" name="Toll Like Receptor TLR6:TLR2 Cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-917937" name="Iron uptake and transport"/>
            <pathway-xref db="Reactome" id="R-HSA-9637628" name="Modulation by Mtb of host immune system"/>
            <pathway-xref db="Reactome" id="R-HSA-166166" name="MyD88-independent TLR4 cascade"/>
            <pathway-xref db="MetaCyc" id="PWY-5105" name="hesperitin glycoside biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5875" name="staphyloxanthin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-4922" name="6-methoxymellein biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-9013406" name="RHOQ GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-3595177" name="Defective CHSY1 causes TPBS"/>
            <pathway-xref db="MetaCyc" id="PWY-8157" name="avenanthramide biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6316" name="aromatic polyketides biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5284" name="shisonin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6848" name="rutin degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7050" name="icosapentaenoate biosynthesis IV (bacteria)"/>
            <pathway-xref db="MetaCyc" id="PWY-7859" name="jasmonoyl-L-isoleucine inactivation"/>
            <pathway-xref db="MetaCyc" id="PWYG-321" name="mycolate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8084" name="daurichromenate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8086" name="(S)-lactate fermentation to propanoate, acetate and hydrogen"/>
            <pathway-xref db="Reactome" id="R-MMU-170984" name="ARMS-mediated activation"/>
            <pathway-xref db="Reactome" id="R-HSA-2243919" name="Crosslinking of collagen fibrils"/>
            <pathway-xref db="Reactome" id="R-DRE-917937" name="Iron uptake and transport"/>
            <pathway-xref db="Reactome" id="R-HSA-3595174" name="Defective CHST14 causes EDS, musculocontractural type"/>
            <pathway-xref db="MetaCyc" id="PWY-6922" name="L-Ndelta-acetylornithine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5846" name="colchicine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5313" name="superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)"/>
            <pathway-xref db="Reactome" id="R-HSA-3656243" name="Defective ST3GAL3 causes MCT12 and EIEE15"/>
            <pathway-xref db="Reactome" id="R-DRE-8854518" name="AURKA Activation by TPX2"/>
            <pathway-xref db="Reactome" id="R-HSA-9660826" name="Purinergic signaling in leishmaniasis infection"/>
            <pathway-xref db="MetaCyc" id="PWY-7708" name="lyngbyatoxin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CFA-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-1236974" name="ER-Phagosome pathway"/>
            <pathway-xref db="MetaCyc" id="PWY-7946" name="sarcinaxanthin diglucoside biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7661" name="protein N-glycosylation (Haloferax volcanii)"/>
            <pathway-xref db="Reactome" id="R-DRE-9013148" name="CDC42 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-CEL-6803207" name="TP53 Regulates Transcription of Caspase Activators and Caspases"/>
            <pathway-xref db="MetaCyc" id="PWY-7960" name="rhabduscin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-1474228" name="Degradation of the extracellular matrix"/>
            <pathway-xref db="MetaCyc" id="PWY-7029" name="terminal olefins biosynthesis II"/>
            <pathway-xref db="MetaCyc" id="PWY-7670" name="fusaridione A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SPO-159231" name="Transport of Mature mRNA Derived from an Intronless Transcript"/>
            <pathway-xref db="Reactome" id="R-DDI-5673001" name="RAF/MAP kinase cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-5654687" name="Downstream signaling of activated FGFR1"/>
            <pathway-xref db="MetaCyc" id="PWY-5160" name="rose anthocyanin biosynthesis I (via cyanidin 5-O-beta-D-glucoside)"/>
            <pathway-xref db="MetaCyc" id="PWY-8207" name="Escherichia coli serotype O:85/Salmonella enterica serotype O:17 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-380270" name="Recruitment of mitotic centrosome proteins and complexes"/>
            <pathway-xref db="Reactome" id="R-HSA-428543" name="Inactivation of CDC42 and RAC1"/>
            <pathway-xref db="Reactome" id="R-HSA-6794361" name="Neurexins and neuroligins"/>
            <pathway-xref db="Reactome" id="R-HSA-9013973" name="TICAM1-dependent activation of IRF3/IRF7"/>
            <pathway-xref db="MetaCyc" id="PWY-7694" name="zwittermicin A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-159227" name="Transport of the SLBP independent Mature mRNA"/>
            <pathway-xref db="Reactome" id="R-HSA-1227986" name="Signaling by ERBB2"/>
            <pathway-xref db="Reactome" id="R-MMU-9013406" name="RHOQ GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-7150" name="polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)"/>
            <pathway-xref db="Reactome" id="R-SPO-159236" name="Transport of Mature mRNA derived from an Intron-Containing Transcript"/>
            <pathway-xref db="Reactome" id="R-HSA-4608870" name="Asymmetric localization of PCP proteins"/>
            <pathway-xref db="MetaCyc" id="PWY-5139" name="pelargonidin conjugates biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6824" name="justicidin B biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7151" name="polymethylated quercetin glucoside biosynthesis II - quercetagetin series (Chrysosplenium)"/>
            <pathway-xref db="MetaCyc" id="PWY-7819" name="poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-983231" name="Factors involved in megakaryocyte development and platelet production"/>
            <pathway-xref db="MetaCyc" id="PWY-5477" name="gallotannin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-9648025" name="EML4 and NUDC in mitotic spindle formation"/>
            <pathway-xref db="Reactome" id="R-MMU-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-977606" name="Regulation of Complement cascade"/>
            <pathway-xref db="MetaCyc" id="PWY-5913" name="partial TCA cycle (obligate autotrophs)"/>
            <pathway-xref db="Reactome" id="R-MMU-8849932" name="Synaptic adhesion-like molecules"/>
            <pathway-xref db="MetaCyc" id="PWY-7599" name="anditomin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-177504" name="Retrograde neurotrophin signalling"/>
            <pathway-xref db="Reactome" id="R-RNO-5673001" name="RAF/MAP kinase cascade"/>
            <pathway-xref db="MetaCyc" id="PWY-7401" name="crotonate fermentation (to acetate and cyclohexane carboxylate)"/>
            <pathway-xref db="Reactome" id="R-DDI-1660516" name="Synthesis of PIPs at the early endosome membrane"/>
            <pathway-xref db="MetaCyc" id="PWY-6415" name="L-ascorbate biosynthesis V (euglena, D-galacturonate pathway)"/>
            <pathway-xref db="MetaCyc" id="PWY-6679" name="jadomycin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5774" name="saponin biosynthesis IV"/>
            <pathway-xref db="Reactome" id="R-HSA-5603041" name="IRAK4 deficiency (TLR2/4)"/>
            <pathway-xref db="Reactome" id="R-MMU-9020702" name="Interleukin-1 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-7168" name="flavonol acylglucoside biosynthesis I - kaempferol derivatives"/>
            <pathway-xref db="MetaCyc" id="PWY-7623" name="astaxanthin dirhamnoside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-214844" name="DL and DIF homodimers complexed with CACT are all phosphorylated in the TL receptor 'signalling complex'"/>
            <pathway-xref db="MetaCyc" id="PWY-5822" name="trichloroethene degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-5307" name="gentiodelphin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-2022857" name="Keratan sulfate degradation"/>
            <pathway-xref db="Reactome" id="R-RNO-216083" name="Integrin cell surface interactions"/>
            <pathway-xref db="MetaCyc" id="PWY-8000" name="vitamin K degradation"/>
            <pathway-xref db="Reactome" id="R-RNO-199418" name="Negative regulation of the PI3K/AKT network"/>
            <pathway-xref db="MetaCyc" id="PWY-2902" name="cytokinin-O-glucosides biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8036" name="chaxamycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-937041" name="IKK complex recruitment mediated by RIP1"/>
            <pathway-xref db="MetaCyc" id="PWY-7743" name="dimycocerosyl triglycosyl phenolphthiocerol biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-2024101" name="CS/DS degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-8237" name="Escherichia coli serotype O:1B/Salmonella enterica serotype O:42 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-9013026" name="RHOB GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-1971475" name="A tetrasaccharide linker sequence is required for GAG synthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-6804115" name="TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"/>
            <pathway-xref db="Reactome" id="R-MMU-5689901" name="Metalloprotease DUBs"/>
            <pathway-xref db="MetaCyc" id="PWY-6971" name="oleandomycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-9034013" name="NTF3 activates NTRK3 signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-429947" name="Deadenylation of mRNA"/>
            <pathway-xref db="Reactome" id="R-MMU-9696264" name="RND3 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-9696270" name="RND2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-GGA-9032759" name="NTRK2 activates RAC1"/>
            <pathway-xref db="Reactome" id="R-HSA-168927" name="TICAM1, RIP1-mediated IKK complex recruitment"/>
            <pathway-xref db="Reactome" id="R-MMU-109704" name="PI3K Cascade"/>
            <pathway-xref db="MetaCyc" id="PWY-6762" name="salicylate glucosides biosynthesis IV"/>
            <pathway-xref db="Reactome" id="R-RNO-388844" name="Receptor-type tyrosine-protein phosphatases"/>
            <pathway-xref db="MetaCyc" id="PWY-5048" name="rosmarinic acid biosynthesis I"/>
            <pathway-xref db="MetaCyc" id="PWY-7897" name="flavonoid di-C-glucosylation"/>
            <pathway-xref db="Reactome" id="R-BTA-114608" name="Platelet degranulation"/>
            <pathway-xref db="Reactome" id="R-HSA-380284" name="Loss of proteins required for interphase microtubule organization from the centrosome"/>
            <pathway-xref db="MetaCyc" id="PWY-8055" name="palmitoyl ethanolamide biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DRE-2022857" name="Keratan sulfate degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7539" name="6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia)"/>
            <pathway-xref db="Reactome" id="R-DDI-983231" name="Factors involved in megakaryocyte development and platelet production"/>
            <pathway-xref db="Reactome" id="R-HSA-380270" name="Recruitment of mitotic centrosome proteins and complexes"/>
            <pathway-xref db="MetaCyc" id="PWY-7450" name="anthocyanidin modification (Arabidopsis)"/>
            <pathway-xref db="MetaCyc" id="PWY-5469" name="sesamin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5926" name="afrormosin conjugates interconversion"/>
            <pathway-xref db="MetaCyc" id="PWY-7354" name="aclacinomycin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7145" name="genistin gentiobioside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-975163" name="IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation"/>
            <pathway-xref db="MetaCyc" id="PWY-8205" name="Escherichia coli serotype O:77/Salmonella enterica serotype O:6,14 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-72163" name="mRNA Splicing - Major Pathway"/>
            <pathway-xref db="MetaCyc" id="PWY-5268" name="salvianin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-2022923" name="Dermatan sulfate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-1810476" name="RIP-mediated NFkB activation via ZBP1"/>
            <pathway-xref db="Reactome" id="R-RNO-1679131" name="Trafficking and processing of endosomal TLR"/>
            <pathway-xref db="Reactome" id="R-DRE-2565942" name="Regulation of PLK1 Activity at G2/M Transition"/>
            <pathway-xref db="MetaCyc" id="PWY-7656" name="Spodoptera littoralis pheromone biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6453" name="stigma estolide biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-3560801" name="Defective B3GAT3 causes JDSSDHD"/>
            <pathway-xref db="MetaCyc" id="PWY-8234" name="Escherichia coli serotype O:183/Shigella boydii serotype O:10 O antigen biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7692" name="bikaverin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7811" name="6-methylpretetramide biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6920" name="6-gingerol analog biosynthesis (engineered)"/>
            <pathway-xref db="Reactome" id="R-HSA-5602566" name="TICAM1 deficiency - HSE"/>
            <pathway-xref db="MetaCyc" id="PWY-7602" name="icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)"/>
            <pathway-xref db="Reactome" id="R-CFA-2022923" name="Dermatan sulfate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-168638" name="NOD1/2 Signaling Pathway"/>
            <pathway-xref db="Reactome" id="R-SSC-1679131" name="Trafficking and processing of endosomal TLR"/>
            <pathway-xref db="MetaCyc" id="PWY-7988" name="baumannoferrin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SSC-109704" name="PI3K Cascade"/>
            <pathway-xref db="MetaCyc" id="PWY-6147" name="6-hydroxymethyl-dihydropterin diphosphate biosynthesis I"/>
            <pathway-xref db="MetaCyc" id="PWY-7687" name="stipitatate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5757" name="fosfomycin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6379" name="alcaligin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7074" name="phenylethanol glycoconjugate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CFA-1679131" name="Trafficking and processing of endosomal TLR"/>
            <pathway-xref db="MetaCyc" id="PWY-7206" name="pyrimidine deoxyribonucleotides dephosphorylation"/>
            <pathway-xref db="Reactome" id="R-RNO-159227" name="Transport of the SLBP independent Mature mRNA"/>
            <pathway-xref db="Reactome" id="R-HSA-8951664" name="Neddylation"/>
            <pathway-xref db="MetaCyc" id="PWY-7730" name="T-2 toxin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DDI-5673000" name="RAF activation"/>
            <pathway-xref db="MetaCyc" id="PWY-8204" name="Salmonella enterica serotype O:54 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-5603037" name="IRAK4 deficiency (TLR5)"/>
            <pathway-xref db="MetaCyc" id="PWY-6930" name="phenolic malonylglucosides biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6627" name="salinosporamide A biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7213" name="wogonin metabolism"/>
            <pathway-xref db="Reactome" id="R-DDI-5675221" name="Negative regulation of MAPK pathway"/>
            <pathway-xref db="Reactome" id="R-MMU-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-CEL-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="MetaCyc" id="PWY-7405" name="aurachin RE biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6657" name="polyhydroxydecanoate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6024" name="isovitexin glycosides biosynthesis"/>
            <pathway-xref db="Reactome" id="R-XTR-2243919" name="Crosslinking of collagen fibrils"/>
            <pathway-xref db="MetaCyc" id="PWY-8242" name="Escherichia coli serotype O:51/Salmonella enterica serotype O:57 O antigen biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5666" name="alpha-solanine/alpha-chaconine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-380320" name="Recruitment of NuMA to mitotic centrosomes"/>
            <pathway-xref db="Reactome" id="R-HSA-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-9025046" name="NTF3 activates NTRK2 (TRKB) signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-3000178" name="ECM proteoglycans"/>
            <pathway-xref db="Reactome" id="R-HSA-446388" name="Regulation of cytoskeletal remodeling and cell spreading by IPP complex components"/>
            <pathway-xref db="Reactome" id="R-MMU-166166" name="MyD88-independent TLR4 cascade"/>
            <pathway-xref db="Reactome" id="R-MMU-9603381" name="Activated NTRK3 signals through PI3K"/>
            <pathway-xref db="MetaCyc" id="PWY-7838" name="globo-series glycosphingolipids biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7633" name="calycosin 7-O-glucoside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-9013423" name="RAC3 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-917937" name="Iron uptake and transport"/>
            <pathway-xref db="Reactome" id="R-MMU-9013149" name="RAC1 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-7984" name="acinetobactin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-5689896" name="Ovarian tumor domain proteases"/>
            <pathway-xref db="MetaCyc" id="PWY-5321" name="quercetin glycoside biosynthesis (Arabidopsis)"/>
            <pathway-xref db="MetaCyc" id="PWY-8235" name="Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-418555" name="G alpha (s) signalling events"/>
          </entry>
          <signature-library-release library="PROSITE_PROFILES" version="2021_01"/>
        </signature>
        <model-ac>PS51450</model-ac>
        <locations>
          <profilescan-location score="7.226811" start="41" end="62">
            <location-fragments>
              <profilescan-location-fragment start="41" end="62" dc-status="CONTINUOUS"/>
            </location-fragments>
            <alignment>TLEKLCLDYNNIRDLPRQLFQC</alignment>
          </profilescan-location>
        </locations>
      </profilescan-match>
      <profilescan-match>
        <signature ac="PS51450" desc="Leucine-rich repeat profile." name="LRR">
          <entry ac="IPR001611" desc="Leucine-rich repeat" name="Leu-rich_rpt" type="REPEAT">
            <go-xref category="MOLECULAR_FUNCTION" db="GO" id="GO:0005515" name="protein binding"/>
            <pathway-xref db="Reactome" id="R-MMU-1474228" name="Degradation of the extracellular matrix"/>
            <pathway-xref db="Reactome" id="R-HSA-2565942" name="Regulation of PLK1 Activity at G2/M Transition"/>
            <pathway-xref db="Reactome" id="R-HSA-5673001" name="RAF/MAP kinase cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-187042" name="TRKA activation by NGF"/>
            <pathway-xref db="Reactome" id="R-MMU-5620912" name="Anchoring of the basal body to the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-MMU-2565942" name="Regulation of PLK1 Activity at G2/M Transition"/>
            <pathway-xref db="MetaCyc" id="PWY-7049" name="icosapentaenoate biosynthesis II (6-desaturase, mammals)"/>
            <pathway-xref db="Reactome" id="R-HSA-1474228" name="Degradation of the extracellular matrix"/>
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            <pathway-xref db="Reactome" id="R-DME-193634" name="Axonal growth inhibition (RHOA activation)"/>
            <pathway-xref db="MetaCyc" id="PWY-8224" name="Escherichia coli serotype O:157/Salmonella enterica serotype O:30 O antigen biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6802" name="salidroside biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8143" name="L-ascorbate biosynthesis VII (plants, D-galacturonate pathway)"/>
            <pathway-xref db="MetaCyc" id="PWY-7824" name="prunasin and amygdalin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-6794361" name="Neurexins and neuroligins"/>
            <pathway-xref db="MetaCyc" id="PWY-7465" name="3,3'-thiodipropanoate degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-5312" name="superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)"/>
            <pathway-xref db="Reactome" id="R-MMU-72163" name="mRNA Splicing - Major Pathway"/>
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            <pathway-xref db="Reactome" id="R-HSA-9617324" name="Negative regulation of NMDA receptor-mediated neuronal transmission"/>
            <pathway-xref db="MetaCyc" id="PWY-7521" name="3-(4-sulfophenyl)butanoate degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-390471" name="Association of TriC/CCT with target proteins during biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5320" name="kaempferol glycoside biosynthesis (Arabidopsis)"/>
            <pathway-xref db="MetaCyc" id="PWY-7714" name="harzianum A and trichodermin biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-HSA-8854050" name="FBXL7 down-regulates AURKA during mitotic entry and in early mitosis"/>
            <pathway-xref db="MetaCyc" id="PWY-8228" name="Porphyromonas gingivalis O-LPS antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-9615933" name="Postmitotic nuclear pore complex (NPC) reformation"/>
            <pathway-xref db="Reactome" id="R-HSA-9034864" name="Activated NTRK3 signals through RAS"/>
            <pathway-xref db="Reactome" id="R-MMU-8854050" name="FBXL7 down-regulates AURKA during mitotic entry and in early mitosis"/>
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            <pathway-xref db="Reactome" id="R-RNO-170968" name="Frs2-mediated activation"/>
            <pathway-xref db="MetaCyc" id="PWY-5353" name="arachidonate biosynthesis I (6-desaturase, lower eukaryotes)"/>
            <pathway-xref db="Reactome" id="R-HSA-4420332" name="Defective B3GALT6 causes EDSP2 and SEMDJL1"/>
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            <pathway-xref db="Reactome" id="R-HSA-159236" name="Transport of Mature mRNA derived from an Intron-Containing Transcript"/>
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            <pathway-xref db="Reactome" id="R-HSA-9679191" name="Potential therapeutics for SARS"/>
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            <pathway-xref db="MetaCyc" id="PWY-8247" name="(Kdo)2-lipid A biosynthesis (P. gingivalis)"/>
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            <pathway-xref db="MetaCyc" id="PWY-5793" name="maysin biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-RNO-198203" name="PI3K/AKT activation"/>
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            <pathway-xref db="MetaCyc" id="PWY-2021" name="indole-3-acetate inactivation IV"/>
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            <pathway-xref db="MetaCyc" id="PWY-7415" name="tylosin biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-7254" name="TCA cycle VII (acetate-producers)"/>
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            <pathway-xref db="Reactome" id="R-RNO-844456" name="The NLRP3 inflammasome"/>
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            <pathway-xref db="MetaCyc" id="PWY-1921" name="indole-3-acetate activation II"/>
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            <pathway-xref db="MetaCyc" id="PWY-5903" name="bacillibactin biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-DME-438066" name="Unblocking of NMDA receptors, glutamate binding and activation"/>
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            <pathway-xref db="MetaCyc" id="PWY-7726" name="(4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase)"/>
            <pathway-xref db="Reactome" id="R-SCE-6798695" name="Neutrophil degranulation"/>
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            <pathway-xref db="MetaCyc" id="PWY-7280" name="ternatin C3 biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-5673000" name="RAF activation"/>
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            <pathway-xref db="MetaCyc" id="PWY-7954" name="tabtoxinine-beta-lactam biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-MMU-5673000" name="RAF activation"/>
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            <pathway-xref db="Reactome" id="R-DRE-380284" name="Loss of proteins required for interphase microtubule organization from the centrosome"/>
            <pathway-xref db="Reactome" id="R-DDI-3295583" name="TRP channels"/>
            <pathway-xref db="MetaCyc" id="PWY-7352" name="daunorubicin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-214862" name="Activated PLL kinase is autophosphorylated in the TL receptor 'signalling complex'"/>
            <pathway-xref db="Reactome" id="R-MMU-9034793" name="Activated NTRK3 signals through PLCG1"/>
            <pathway-xref db="Reactome" id="R-HSA-2022857" name="Keratan sulfate degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-936440" name="Negative regulators of DDX58/IFIH1 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-9696270" name="RND2 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-8230" name="Salmonella enterica serotype O:13 O antigen biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-HSA-159230" name="Transport of the SLBP Dependant Mature mRNA"/>
            <pathway-xref db="MetaCyc" id="PWY-7449" name="acylated cyanidin galactoside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9665233" name="Resistance of ERBB2 KD mutants to trastuzumab"/>
            <pathway-xref db="Reactome" id="R-MMU-159230" name="Transport of the SLBP Dependant Mature mRNA"/>
            <pathway-xref db="Reactome" id="R-HSA-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-HSA-936440" name="Negative regulators of DDX58/IFIH1 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-8116" name="ochratoxin A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-975110" name="TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-975155" name="MyD88 dependent cascade initiated on endosome"/>
            <pathway-xref db="MetaCyc" id="PWY-8081" name="leucine-derived hydroxynitrile glucoside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-BTA-1474228" name="Degradation of the extracellular matrix"/>
            <pathway-xref db="Reactome" id="R-HSA-5602498" name="MyD88 deficiency (TLR2/4)"/>
            <pathway-xref db="Reactome" id="R-SPO-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="MetaCyc" id="PWY-6373" name="acrylate degradation I"/>
            <pathway-xref db="Reactome" id="R-DRE-9696270" name="RND2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-5602415" name="UNC93B1 deficiency - HSE"/>
            <pathway-xref db="Reactome" id="R-HSA-2500257" name="Resolution of Sister Chromatid Cohesion"/>
            <pathway-xref db="MetaCyc" id="PWY-1901" name="aurone biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9032845" name="Activated NTRK2 signals through CDK5"/>
            <pathway-xref db="Reactome" id="R-MMU-9013404" name="RAC2 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-5129" name="sphingolipid biosynthesis (plants)"/>
            <pathway-xref db="Reactome" id="R-HSA-9673221" name="Defective F9 activation"/>
            <pathway-xref db="MetaCyc" id="PWY-7461" name="hydroxycinnamate sugar acid ester biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SCE-9696270" name="RND2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-193634" name="Axonal growth inhibition (RHOA activation)"/>
            <pathway-xref db="Reactome" id="R-HSA-168179" name="Toll Like Receptor TLR1:TLR2 Cascade"/>
            <pathway-xref db="MetaCyc" id="PWY-7945" name="2,2'-bis-(4-hydroxy-3-methybut-2-enyl)-beta,beta-carotene monoglucoside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-450321" name="JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1"/>
            <pathway-xref db="MetaCyc" id="PWY-7653" name="griseofulvin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DDI-381676" name="Glucagon-like Peptide-1 (GLP1) regulates insulin secretion"/>
            <pathway-xref db="MetaCyc" id="PWY-8012" name="mupirocin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9013424" name="RHOV GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-4801" name="aloesone biosynthesis I"/>
            <pathway-xref db="Reactome" id="R-HSA-167021" name="PLC-gamma1 signalling"/>
            <pathway-xref db="MetaCyc" id="PWY-7171" name="flavonol acylglucoside biosynthesis II - isorhamnetin derivatives"/>
            <pathway-xref db="Reactome" id="R-SCE-9615933" name="Postmitotic nuclear pore complex (NPC) reformation"/>
            <pathway-xref db="Reactome" id="R-RNO-187042" name="TRKA activation by NGF"/>
            <pathway-xref db="MetaCyc" id="PWY-5094" name="naringenin glycoside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-5620916" name="VxPx cargo-targeting to cilium"/>
            <pathway-xref db="Reactome" id="R-CFA-2022870" name="Chondroitin sulfate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-1461957" name="Beta defensins"/>
            <pathway-xref db="MetaCyc" id="PWY-7679" name="anthocyanidin acylglucoside and acylsambubioside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9652282" name="Drug-mediated inhibition of ERBB2 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-6958" name="icosapentaenoate biosynthesis I (lower eukaryotes)"/>
            <pathway-xref db="Reactome" id="R-HSA-5602410" name="TLR3 deficiency - HSE"/>
            <pathway-xref db="Reactome" id="R-XTR-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-DDI-1632852" name="Macroautophagy"/>
            <pathway-xref db="Reactome" id="R-HSA-373752" name="Netrin-1 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-166020" name="Transfer of LPS from LBP carrier to CD14"/>
            <pathway-xref db="MetaCyc" id="PWY-4421" name="curcumin glucoside biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8257" name="Escherichia coli serotype O:52 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DRE-380320" name="Recruitment of NuMA to mitotic centrosomes"/>
            <pathway-xref db="MetaCyc" id="PWY-5475" name="pentagalloylglucose biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7922" name="protein O-mannosylation II (mammals, core M1 and core M2)"/>
            <pathway-xref db="Reactome" id="R-RNO-381426" name="Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"/>
            <pathway-xref db="Reactome" id="R-DRE-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7688" name="dTDP-alpha-D-ravidosamine and dTDP-4-acetyl-alpha-D-ravidosamine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9634285" name="Constitutive Signaling by Overexpressed ERBB2"/>
            <pathway-xref db="MetaCyc" id="PWY-8226" name="Escherichia coli serotype O:152 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-5223345" name="Miscellaneous transport and binding events"/>
            <pathway-xref db="MetaCyc" id="PWY-7713" name="nivalenol biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7412" name="mycinamicin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-141444" name="Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"/>
            <pathway-xref db="MetaCyc" id="PWY-7669" name="equisetin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-380259" name="Loss of Nlp from mitotic centrosomes"/>
            <pathway-xref db="Reactome" id="R-SCE-3108232" name="SUMO E3 ligases SUMOylate target proteins"/>
            <pathway-xref db="Reactome" id="R-HSA-8985586" name="SLIT2:ROBO1 increases RHOA activity"/>
            <pathway-xref db="MetaCyc" id="PWY-7470" name="phosphatidylcholine biosynthesis VII"/>
            <pathway-xref db="Reactome" id="R-MMU-5654687" name="Downstream signaling of activated FGFR1"/>
            <pathway-xref db="MetaCyc" id="PWY-5342" name="ajugose biosynthesis I (galactinol-dependent)"/>
            <pathway-xref db="Reactome" id="R-DDI-5675482" name="Regulation of necroptotic cell death"/>
            <pathway-xref db="MetaCyc" id="PWY-6944" name="androstenedione degradation I (aerobic)"/>
            <pathway-xref db="MetaCyc" id="PWY-7561" name="tenellin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SPO-199418" name="Negative regulation of the PI3K/AKT network"/>
            <pathway-xref db="MetaCyc" id="PWY-8209" name="Escherichia coli serotype O:15 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-214869" name="Phosphorylated CACT, DL and DIF homodimers dissociate from the TL receptor 'signalling complex'"/>
            <pathway-xref db="MetaCyc" id="PWY-7884" name="lipoprotein posttranslational modification"/>
            <pathway-xref db="MetaCyc" id="PWY-7659" name="viridicatumtoxin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-84" name="resveratrol biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-140837" name="Intrinsic Pathway of Fibrin Clot Formation"/>
            <pathway-xref db="MetaCyc" id="PWY-7250" name="[2Fe-2S] iron-sulfur cluster biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-2243919" name="Crosslinking of collagen fibrils"/>
            <pathway-xref db="Reactome" id="R-HSA-168164" name="Toll Like Receptor 3 (TLR3) Cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-166016" name="Toll Like Receptor 4 (TLR4) Cascade"/>
            <pathway-xref db="Reactome" id="R-MMU-445989" name="TAK1 activates NFkB by phosphorylation and activation of IKKs complex"/>
            <pathway-xref db="MetaCyc" id="PWY-7728" name="(4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase)"/>
            <pathway-xref db="MetaCyc" id="PWY-8250" name="Escherichia coli serotype O:9 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-140534" name="Caspase activation via Death Receptors in the presence of ligand"/>
            <pathway-xref db="Reactome" id="R-CEL-3108232" name="SUMO E3 ligases SUMOylate target proteins"/>
            <pathway-xref db="Reactome" id="R-DME-159231" name="Transport of Mature mRNA Derived from an Intronless Transcript"/>
            <pathway-xref db="MetaCyc" id="PWY-6655" name="xanthan biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-209968" name="Thyroxine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8222" name="Escherichia coli serotype O:128 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-438066" name="Unblocking of NMDA receptors, glutamate binding and activation"/>
            <pathway-xref db="MetaCyc" id="PWY-5381" name="NAD salvage (plants)"/>
            <pathway-xref db="MetaCyc" id="PWY-6010" name="apigenin glycosides biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7746" name="mycobacterial sulfolipid biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-187024" name="NGF-independant TRKA activation"/>
            <pathway-xref db="MetaCyc" id="PWY-8151" name="cholesterol degradation to androstenedione III (anaerobic)"/>
            <pathway-xref db="Reactome" id="R-HSA-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-166020" name="Transfer of LPS from LBP carrier to CD14"/>
            <pathway-xref db="MetaCyc" id="PWY-7002" name="4-hydroxyacetophenone degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7053" name="docosahexaenoate biosynthesis I (lower eukaryotes)"/>
            <pathway-xref db="Reactome" id="R-MMU-166016" name="Toll Like Receptor 4 (TLR4) Cascade"/>
            <pathway-xref db="Reactome" id="R-RNO-5654687" name="Downstream signaling of activated FGFR1"/>
            <pathway-xref db="Reactome" id="R-HSA-844456" name="The NLRP3 inflammasome"/>
            <pathway-xref db="Reactome" id="R-HSA-170968" name="Frs2-mediated activation"/>
            <pathway-xref db="Reactome" id="R-MMU-1227986" name="Signaling by ERBB2"/>
            <pathway-xref db="Reactome" id="R-MMU-114608" name="Platelet degranulation"/>
            <pathway-xref db="MetaCyc" id="PWY-8208" name="Salmonella enterica serotype O:6,7 O antigen biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7487" name="(+)-secoisolariciresinol diglucoside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-159231" name="Transport of Mature mRNA Derived from an Intronless Transcript"/>
            <pathway-xref db="Reactome" id="R-HSA-450302" name="activated TAK1 mediates p38 MAPK activation"/>
            <pathway-xref db="Reactome" id="R-BTA-2022854" name="Keratan sulfate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8243" name="colanic acid (Escherichia coli K12) biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-844456" name="The NLRP3 inflammasome"/>
            <pathway-xref db="Reactome" id="R-HSA-198203" name="PI3K/AKT activation"/>
            <pathway-xref db="Reactome" id="R-HSA-114608" name="Platelet degranulation"/>
            <pathway-xref db="Reactome" id="R-MMU-199418" name="Negative regulation of the PI3K/AKT network"/>
            <pathway-xref db="MetaCyc" id="PWY-7816" name="poly(ribitol phosphate) wall teichoic acid biosynthesis II (S. aureus)"/>
            <pathway-xref db="Reactome" id="R-HSA-428540" name="Activation of RAC1"/>
            <pathway-xref db="MetaCyc" id="PWY-8045" name="cylindrospermopsin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-HSA-168142" name="Toll Like Receptor 10 (TLR10) Cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-198745" name="Signalling to STAT3"/>
            <pathway-xref db="Reactome" id="R-MMU-450302" name="activated TAK1 mediates p38 MAPK activation"/>
            <pathway-xref db="MetaCyc" id="PWY-83" name="monolignol glucosides biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7719" name="CMP-diacetamido-8-epilegionaminic acid biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7690" name="holomycin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5392" name="reductive TCA cycle II"/>
            <pathway-xref db="Reactome" id="R-BTA-5223345" name="Miscellaneous transport and binding events"/>
            <pathway-xref db="Reactome" id="R-HSA-9648025" name="EML4 and NUDC in mitotic spindle formation"/>
            <pathway-xref db="MetaCyc" id="PWY-5380" name="A series fagopyritols biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5660" name="taxol biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-2024101" name="CS/DS degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-430116" name="GP1b-IX-V activation signalling"/>
            <pathway-xref db="Reactome" id="R-HSA-5689901" name="Metalloprotease DUBs"/>
            <pathway-xref db="MetaCyc" id="PWY-7696" name="citreoisocoumarin and bikisocoumarin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7342" name="superpathway of nicotine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9013026" name="RHOB GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-6797" name="6-hydroxymethyl-dihydropterin diphosphate biosynthesis II (Methanocaldococcus)"/>
            <pathway-xref db="Reactome" id="R-BTA-3000178" name="ECM proteoglycans"/>
            <pathway-xref db="MetaCyc" id="PWY-7740" name="beta-D-mannosyl phosphomycoketide biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-937072" name="TRAF6-mediated induction of TAK1 complex within TLR4 complex"/>
            <pathway-xref db="Reactome" id="R-HSA-187706" name="Signalling to p38 via RIT and RIN"/>
            <pathway-xref db="Reactome" id="R-CEL-8951664" name="Neddylation"/>
            <pathway-xref db="MetaCyc" id="PWY-8233" name="Escherichia coli serotype O:169 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DDI-1660499" name="Synthesis of PIPs at the plasma membrane"/>
            <pathway-xref db="MetaCyc" id="PWY-7592" name="arachidonate biosynthesis III (6-desaturase, mammals)"/>
            <pathway-xref db="MetaCyc" id="PWY-8217" name="Escherichia coli serotype O:55/Salmonella enterica serotype O:50 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-8849932" name="Synaptic adhesion-like molecules"/>
            <pathway-xref db="MetaCyc" id="PWY-8206" name="Salmonella enterica serotype O:18 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9660821" name="ADORA2B mediated anti-inflammatory cytokines production"/>
            <pathway-xref db="MetaCyc" id="PWY-8152" name="androstenedione degradation II (anaerobic)"/>
            <pathway-xref db="MetaCyc" id="PWY-361" name="phenylpropanoid biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9664565" name="Signaling by ERBB2 KD Mutants"/>
            <pathway-xref db="Reactome" id="R-HSA-1971475" name="A tetrasaccharide linker sequence is required for GAG synthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7570" name="blasticidin S biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-5617472" name="Activation of anterior HOX genes in hindbrain development during early embryogenesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5984" name="rifamycin B biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6442" name="spermidine hydroxycinnamic acid conjugates biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SPO-159227" name="Transport of the SLBP independent Mature mRNA"/>
            <pathway-xref db="MetaCyc" id="PWY-8253" name="Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7921" name="protein O-mannosylation I (yeast)"/>
            <pathway-xref db="MetaCyc" id="PWY-7530" name="Escherichia coli serotype O:104 O antigen biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7491" name="podophyllotoxin glucosides metabolism"/>
            <pathway-xref db="Reactome" id="R-HSA-9609736" name="Assembly and cell surface presentation of NMDA receptors"/>
            <pathway-xref db="Reactome" id="R-RNO-450520" name="HuR (ELAVL1) binds and stabilizes mRNA"/>
            <pathway-xref db="MetaCyc" id="PWY-7463" name="N-methylanthraniloyl-beta-D-glucopyranose biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7166" name="kaempferide triglycoside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-5689896" name="Ovarian tumor domain proteases"/>
            <pathway-xref db="Reactome" id="R-MMU-163125" name="Post-translational modification: synthesis of GPI-anchored proteins"/>
            <pathway-xref db="MetaCyc" id="PWY-6673" name="caffeoylglucarate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9707564" name="Cytoprotection by HMOX1"/>
            <pathway-xref db="MetaCyc" id="PWY-6799" name="fatty acid biosynthesis initiation (plant mitochondria)"/>
            <pathway-xref db="MetaCyc" id="PWY-7658" name="protein N-glycosylation (Methanococcus voltae)"/>
            <pathway-xref db="Reactome" id="R-RNO-2022870" name="Chondroitin sulfate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9603381" name="Activated NTRK3 signals through PI3K"/>
            <pathway-xref db="Reactome" id="R-HSA-9034013" name="NTF3 activates NTRK3 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-6804115" name="TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"/>
            <pathway-xref db="MetaCyc" id="PWY-7706" name="dapdiamides biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7318" name="dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7986" name="anguibactin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9696270" name="RND2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DME-214874" name="PLL kinase binds to TUB in the TL receptor 'signalling complex'"/>
            <pathway-xref db="Reactome" id="R-HSA-9696264" name="RND3 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-1981" name="indole-3-acetate inactivation III"/>
            <pathway-xref db="Reactome" id="R-RNO-9028731" name="Activated NTRK2 signals through FRS2 and FRS3"/>
            <pathway-xref db="MetaCyc" id="PWY-7407" name="aurachin A, B, C and D biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-141444" name="Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"/>
            <pathway-xref db="Reactome" id="R-HSA-9013149" name="RAC1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-9615933" name="Postmitotic nuclear pore complex (NPC) reformation"/>
            <pathway-xref db="Reactome" id="R-HSA-9013423" name="RAC3 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-6310" name="aloesone biosynthesis II"/>
            <pathway-xref db="Reactome" id="R-SCE-199418" name="Negative regulation of the PI3K/AKT network"/>
            <pathway-xref db="Reactome" id="R-HSA-428542" name="Regulation of commissural axon pathfinding by SLIT and ROBO"/>
            <pathway-xref db="Reactome" id="R-DME-4615885" name="SUMOylation of DNA replication proteins"/>
            <pathway-xref db="MetaCyc" id="PWY-7191" name="kaempferol diglycoside biosynthesis (pollen-specific)"/>
            <pathway-xref db="MetaCyc" id="PWY-7815" name="poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)"/>
            <pathway-xref db="Reactome" id="R-RNO-159236" name="Transport of Mature mRNA derived from an Intron-Containing Transcript"/>
            <pathway-xref db="MetaCyc" id="PWY-5794" name="malonate degradation I (biotin-independent)"/>
            <pathway-xref db="MetaCyc" id="PWY-2901" name="cytokinins 9-N-glucoside biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7129" name="quercetin glucoside biosynthesis (Allium)"/>
            <pathway-xref db="Reactome" id="R-HSA-9020702" name="Interleukin-1 signaling"/>
            <pathway-xref db="Reactome" id="R-DRE-380259" name="Loss of Nlp from mitotic centrosomes"/>
            <pathway-xref db="MetaCyc" id="PWY-7712" name="deoxynivalenol biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-193634" name="Axonal growth inhibition (RHOA activation)"/>
            <pathway-xref db="Reactome" id="R-MMU-6794361" name="Neurexins and neuroligins"/>
            <pathway-xref db="MetaCyc" id="PWY-5466" name="matairesinol biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5461" name="betanidin degradation"/>
            <pathway-xref db="Reactome" id="R-SPO-163210" name="Formation of ATP by chemiosmotic coupling"/>
            <pathway-xref db="Reactome" id="R-SCE-5223345" name="Miscellaneous transport and binding events"/>
            <pathway-xref db="Reactome" id="R-HSA-6803207" name="TP53 Regulates Transcription of Caspase Activators and Caspases"/>
            <pathway-xref db="Reactome" id="R-HSA-4615885" name="SUMOylation of DNA replication proteins"/>
            <pathway-xref db="MetaCyc" id="PWY-7382" name="lipoate biosynthesis and incorporation IV (yeast)"/>
            <pathway-xref db="MetaCyc" id="PWY-8035" name="streptovaricin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-6803207" name="TP53 Regulates Transcription of Caspase Activators and Caspases"/>
            <pathway-xref db="MetaCyc" id="PWY-7583" name="arachidonate biosynthesis II (bacteria)"/>
            <pathway-xref db="MetaCyc" id="PWY-7460" name="2-O-acetyl-3-O-trans-coutarate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5310" name="superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)"/>
            <pathway-xref db="Reactome" id="R-HSA-6807004" name="Negative regulation of MET activity"/>
            <pathway-xref db="Reactome" id="R-HSA-9032759" name="NTRK2 activates RAC1"/>
            <pathway-xref db="Reactome" id="R-HSA-877300" name="Interferon gamma signaling"/>
            <pathway-xref db="Reactome" id="R-DDI-9013149" name="RAC1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DME-9013406" name="RHOQ GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-8863795" name="Downregulation of ERBB2 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-8051" name="anandamide biosynthesis I"/>
            <pathway-xref db="Reactome" id="R-HSA-75892" name="Platelet Adhesion to exposed collagen"/>
            <pathway-xref db="Reactome" id="R-MMU-4615885" name="SUMOylation of DNA replication proteins"/>
            <pathway-xref db="Reactome" id="R-MMU-8857538" name="PTK6 promotes HIF1A stabilization"/>
            <pathway-xref db="Reactome" id="R-HSA-9620244" name="Long-term potentiation"/>
            <pathway-xref db="Reactome" id="R-RNO-444821" name="Relaxin receptors"/>
            <pathway-xref db="Reactome" id="R-HSA-3656225" name="Defective CHST6 causes MCDC1"/>
            <pathway-xref db="Reactome" id="R-SPO-9696270" name="RND2 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-641" name="proanthocyanidins biosynthesis from flavanols"/>
            <pathway-xref db="Reactome" id="R-HSA-8875360" name="InlB-mediated entry of Listeria monocytogenes into host cell"/>
            <pathway-xref db="Reactome" id="R-HSA-1606341" name="IRF3 mediated activation of type 1 IFN"/>
            <pathway-xref db="Reactome" id="R-HSA-8863795" name="Downregulation of ERBB2 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-8231" name="Escherichia coli serotype O:127 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-167044" name="Signalling to RAS"/>
            <pathway-xref db="Reactome" id="R-RNO-438066" name="Unblocking of NMDA receptors, glutamate binding and activation"/>
            <pathway-xref db="Reactome" id="R-MMU-9013408" name="RHOG GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-7820" name="teichuronic acid biosynthesis (B. subtilis 168)"/>
            <pathway-xref db="Reactome" id="R-MMU-6807004" name="Negative regulation of MET activity"/>
            <pathway-xref db="Reactome" id="R-HSA-9603505" name="NTRK3 as a dependence receptor"/>
            <pathway-xref db="Reactome" id="R-MMU-187042" name="TRKA activation by NGF"/>
            <pathway-xref db="Reactome" id="R-HSA-8857538" name="PTK6 promotes HIF1A stabilization"/>
            <pathway-xref db="Reactome" id="R-HSA-3595172" name="Defective CHST3 causes SEDCJD"/>
            <pathway-xref db="Reactome" id="R-RNO-8849932" name="Synaptic adhesion-like molecules"/>
            <pathway-xref db="Reactome" id="R-HSA-9665251" name="Resistance of ERBB2 KD mutants to lapatinib"/>
            <pathway-xref db="MetaCyc" id="PWY-81" name="toluene degradation to benzoyl-CoA (anaerobic)"/>
            <pathway-xref db="MetaCyc" id="PWY-8218" name="Escherichia coli serotype O:56 O antigen biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7532" name="acetylaszonalenin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5835" name="geranyl acetate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6728" name="methylaspartate cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-6036" name="cardenolide glucosides biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-1839117" name="Signaling by cytosolic FGFR1 fusion mutants"/>
            <pathway-xref db="Reactome" id="R-MMU-2022870" name="Chondroitin sulfate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CFA-3000178" name="ECM proteoglycans"/>
            <pathway-xref db="MetaCyc" id="PWY-8219" name="Escherichia coli serotype O:107 O antigen biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5397" name="crocetin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9665348" name="Signaling by ERBB2 ECD mutants"/>
            <pathway-xref db="MetaCyc" id="PWY-7671" name="saframycin A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-5689901" name="Metalloprotease DUBs"/>
            <pathway-xref db="Reactome" id="R-HSA-9013408" name="RHOG GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-6658" name="acetan biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7693" name="guadinomine B biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-936964" name="Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon"/>
            <pathway-xref db="Reactome" id="R-HSA-9665246" name="Resistance of ERBB2 KD mutants to neratinib"/>
            <pathway-xref db="Reactome" id="R-HSA-844455" name="The NLRP1 inflammasome"/>
            <pathway-xref db="MetaCyc" id="PWY-8166" name="emodin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-375281" name="Hormone ligand-binding receptors"/>
            <pathway-xref db="Reactome" id="R-HSA-381426" name="Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"/>
            <pathway-xref db="Reactome" id="R-BTA-2022923" name="Dermatan sulfate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6502" name="8-oxo-(d)GTP detoxification I"/>
            <pathway-xref db="Reactome" id="R-DME-72163" name="mRNA Splicing - Major Pathway"/>
            <pathway-xref db="MetaCyc" id="PWY-7071" name="steviol glucoside biosynthesis (rebaudioside A biosynthesis)"/>
            <pathway-xref db="MetaCyc" id="PWY-5343" name="ajugose biosynthesis II (galactinol-independent)"/>
            <pathway-xref db="MetaCyc" id="PWY-7989" name="acinetoferrin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7677" name="rosamicin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7261" name="anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)"/>
            <pathway-xref db="Reactome" id="R-HSA-9032500" name="Activated NTRK2 signals through FYN"/>
            <pathway-xref db="Reactome" id="R-HSA-9665250" name="Resistance of ERBB2 KD mutants to AEE788"/>
            <pathway-xref db="MetaCyc" id="PWY-8248" name="lipid A-core biosynthesis (P. gingivalis)"/>
            <pathway-xref db="MetaCyc" id="PWY-7702" name="sch210971 and sch210972 biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-5682910" name="LGI-ADAM interactions"/>
            <pathway-xref db="MetaCyc" id="PWY-7253" name="apigeninidin 5-O-glucoside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9028335" name="Activated NTRK2 signals through PI3K"/>
            <pathway-xref db="Reactome" id="R-CFA-109704" name="PI3K Cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-9013148" name="CDC42 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-6558" name="heparan sulfate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-168176" name="Toll Like Receptor 5 (TLR5) Cascade"/>
            <pathway-xref db="MetaCyc" id="PWY-5690" name="TCA cycle II (plants and fungi)"/>
            <pathway-xref db="Reactome" id="R-MMU-75892" name="Platelet Adhesion to exposed collagen"/>
            <pathway-xref db="Reactome" id="R-HSA-8950505" name="Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation"/>
            <pathway-xref db="MetaCyc" id="PWY-6056" name="dimethylsulfoniopropanoate degradation II (cleavage)"/>
            <pathway-xref db="Reactome" id="R-HSA-168928" name="DDX58/IFIH1-mediated induction of interferon-alpha/beta"/>
            <pathway-xref db="Reactome" id="R-HSA-166058" name="MyD88:MAL(TIRAP) cascade initiated on plasma membrane"/>
            <pathway-xref db="MetaCyc" id="PWY-7452" name="cyanidin dimalonylglucoside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-168138" name="Toll Like Receptor 9 (TLR9) Cascade"/>
            <pathway-xref db="MetaCyc" id="PWY-8038" name="naphthomycin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7055" name="daphnetin modification"/>
            <pathway-xref db="MetaCyc" id="PWY-7737" name="thiocoraline biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-9013148" name="CDC42 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-5759" name="saponin biosynthesis III"/>
            <pathway-xref db="MetaCyc" id="PWY-7458" name="violdelphin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7672" name="fusaric acid biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7529" name="CMP-N-acetyl-7-O-acetylneuraminate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-8985801" name="Regulation of cortical dendrite branching"/>
            <pathway-xref db="Reactome" id="R-HSA-9662360" name="Sensory processing of sound by inner hair cells of the cochlea"/>
            <pathway-xref db="Reactome" id="R-CEL-376176" name="Signaling by ROBO receptors"/>
            <pathway-xref db="Reactome" id="R-HSA-4641263" name="Regulation of FZD by ubiquitination"/>
            <pathway-xref db="MetaCyc" id="PWY-5797" name="indole-3-acetate inactivation VI"/>
            <pathway-xref db="MetaCyc" id="PWY-5679" name="clavulanate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9013409" name="RHOJ GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-7511" name="protein ubiquitination"/>
            <pathway-xref db="MetaCyc" id="PWY-8075" name="(Kdo)2-lipid A biosynthesis (P. putida)"/>
            <pathway-xref db="MetaCyc" id="PWY-7821" name="tunicamycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-450520" name="HuR (ELAVL1) binds and stabilizes mRNA"/>
            <pathway-xref db="Reactome" id="R-DME-159230" name="Transport of the SLBP Dependant Mature mRNA"/>
            <pathway-xref db="MetaCyc" id="PWY-1961" name="indole-3-acetate inactivation I"/>
            <pathway-xref db="Reactome" id="R-HSA-428890" name="Role of ABL in ROBO-SLIT signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-4641263" name="Regulation of FZD by ubiquitination"/>
            <pathway-xref db="Reactome" id="R-MMU-9032759" name="NTRK2 activates RAC1"/>
            <pathway-xref db="Reactome" id="R-RNO-936440" name="Negative regulators of DDX58/IFIH1 signaling"/>
            <pathway-xref db="Reactome" id="R-DDI-1169092" name="Activation of RAS in B cells"/>
            <pathway-xref db="Reactome" id="R-RNO-163125" name="Post-translational modification: synthesis of GPI-anchored proteins"/>
            <pathway-xref db="Reactome" id="R-MMU-3000178" name="ECM proteoglycans"/>
            <pathway-xref db="Reactome" id="R-RNO-9034793" name="Activated NTRK3 signals through PLCG1"/>
            <pathway-xref db="MetaCyc" id="PWY-7265" name="lampranthin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-198203" name="PI3K/AKT activation"/>
            <pathway-xref db="Reactome" id="R-HSA-9013406" name="RHOQ GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-7818" name="type IV lipoteichoic acid biosynthesis (S. pneumoniae)"/>
            <pathway-xref db="MetaCyc" id="PWY-6385" name="peptidoglycan biosynthesis III (mycobacteria)"/>
            <pathway-xref db="Reactome" id="R-GGA-517856" name="TLR2 subfamily cascade"/>
            <pathway-xref db="MetaCyc" id="PWY-7624" name="nystatin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6397" name="mycolyl-arabinogalactan-peptidoglycan complex biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-446388" name="Regulation of cytoskeletal remodeling and cell spreading by IPP complex components"/>
            <pathway-xref db="MetaCyc" id="PWY-7601" name="arachidonate biosynthesis IV (8-detaturase, lower eukaryotes)"/>
            <pathway-xref db="MetaCyc" id="PWY-8249" name="xanthommatin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-2467813" name="Separation of Sister Chromatids"/>
            <pathway-xref db="Reactome" id="R-DRE-8854050" name="FBXL7 down-regulates AURKA during mitotic entry and in early mitosis"/>
            <pathway-xref db="Reactome" id="R-RNO-8951664" name="Neddylation"/>
            <pathway-xref db="Reactome" id="R-DME-214842" name="DL and DIF homodimers bind to TUB and phosphorylated PLL in the TL receptor 'signalling complex'"/>
            <pathway-xref db="Reactome" id="R-HSA-2467813" name="Separation of Sister Chromatids"/>
            <pathway-xref db="MetaCyc" id="PWY-8212" name="Escherichia coli serotype O:8 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-8936459" name="RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"/>
            <pathway-xref db="MetaCyc" id="PWY-7983" name="pseudomonine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DDI-202670" name="ERKs are inactivated"/>
            <pathway-xref db="Reactome" id="R-MMU-388844" name="Receptor-type tyrosine-protein phosphatases"/>
            <pathway-xref db="MetaCyc" id="PWY-5400" name="amaranthin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-8854518" name="AURKA Activation by TPX2"/>
            <pathway-xref db="Reactome" id="R-MMU-977606" name="Regulation of Complement cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-168181" name="Toll Like Receptor 7/8 (TLR7/8) Cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-9026527" name="Activated NTRK2 signals through PLCG1"/>
            <pathway-xref db="Reactome" id="R-MMU-170968" name="Frs2-mediated activation"/>
            <pathway-xref db="MetaCyc" id="PWY-6322" name="phosphinothricin tripeptide biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5710" name="capsaicin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-DRE-9696264" name="RND3 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-5437" name="L-threonine degradation I"/>
            <pathway-xref db="MetaCyc" id="PWY-7474" name="avenacin A-2 biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9034015" name="Signaling by NTRK3 (TRKC)"/>
            <pathway-xref db="MetaCyc" id="PWY-5379" name="B series fagopyritols biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-2562578" name="TRIF-mediated programmed cell death"/>
            <pathway-xref db="MetaCyc" id="PWY-7037" name="protein O-glycosylation (Neisseria)"/>
            <pathway-xref db="Reactome" id="R-HSA-2562578" name="TRIF-mediated programmed cell death"/>
            <pathway-xref db="Reactome" id="R-DDI-5621575" name="CD209 (DC-SIGN) signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-844455" name="The NLRP1 inflammasome"/>
            <pathway-xref db="Reactome" id="R-DME-376176" name="Signaling by ROBO receptors"/>
            <pathway-xref db="Reactome" id="R-MMU-159227" name="Transport of the SLBP independent Mature mRNA"/>
            <pathway-xref db="Reactome" id="R-MMU-159236" name="Transport of Mature mRNA derived from an Intron-Containing Transcript"/>
            <pathway-xref db="MetaCyc" id="PWY-7172" name="flavonol acylglucoside biosynthesis III - quercetin derivatives"/>
            <pathway-xref db="MetaCyc" id="PWY-6314" name="plumbagin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-376176" name="Signaling by ROBO receptors"/>
            <pathway-xref db="Reactome" id="R-GGA-451514" name="MyD88:TIRAP-dependent cascade initiated on plasma membrane"/>
            <pathway-xref db="MetaCyc" id="PWY-6032" name="digitoxigenin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DRE-8951664" name="Neddylation"/>
            <pathway-xref db="MetaCyc" id="PWY-7473" name="avenacin A-1 biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-6803207" name="TP53 Regulates Transcription of Caspase Activators and Caspases"/>
            <pathway-xref db="Reactome" id="R-GGA-388844" name="Receptor-type tyrosine-protein phosphatases"/>
            <pathway-xref db="Reactome" id="R-HSA-8854518" name="AURKA Activation by TPX2"/>
            <pathway-xref db="MetaCyc" id="PWY-7716" name="penicillin G and penicillin V biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DDI-1483248" name="Synthesis of PIPs at the ER membrane"/>
            <pathway-xref db="MetaCyc" id="PWY-7192" name="quercetin diglycoside biosynthesis (pollen-specific)"/>
            <pathway-xref db="MetaCyc" id="PWY-6190" name="2,4-dichlorotoluene degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7475" name="des-methyl avenacin A-1 biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6623" name="salicylate glucosides biosynthesis II"/>
            <pathway-xref db="MetaCyc" id="PWY-7045" name="mithramycin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6015" name="vitexin and derivatives biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5286" name="anthocyanidin sophoroside metabolism"/>
            <pathway-xref db="Reactome" id="R-RNO-9034013" name="NTF3 activates NTRK3 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-6624" name="salicylate glucosides biosynthesis III"/>
            <pathway-xref db="Reactome" id="R-MMU-9013106" name="RHOC GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-216083" name="Integrin cell surface interactions"/>
            <pathway-xref db="Reactome" id="R-HSA-2022923" name="Dermatan sulfate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-8941413" name="Events associated with phagocytolytic activity of PMN cells"/>
            <pathway-xref db="Reactome" id="R-DME-159236" name="Transport of Mature mRNA derived from an Intron-Containing Transcript"/>
            <pathway-xref db="Reactome" id="R-DDI-193648" name="NRAGE signals death through JNK"/>
            <pathway-xref db="Reactome" id="R-GGA-2022854" name="Keratan sulfate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-BTA-1971475" name="A tetrasaccharide linker sequence is required for GAG synthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-3656244" name="Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)"/>
            <pathway-xref db="MetaCyc" id="PWY-5473" name="hydroxycinnamic acid serotonin amides biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-109704" name="PI3K Cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-3134975" name="Regulation of innate immune responses to cytosolic DNA"/>
            <pathway-xref db="Reactome" id="R-HSA-159231" name="Transport of Mature mRNA Derived from an Intronless Transcript"/>
            <pathway-xref db="MetaCyc" id="PWY-8289" name="dZTP biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-3270619" name="IRF3-mediated induction of type I IFN"/>
            <pathway-xref db="Reactome" id="R-DDI-354192" name="Integrin signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-975871" name="MyD88 cascade initiated on plasma membrane"/>
            <pathway-xref db="Reactome" id="R-MMU-3134975" name="Regulation of innate immune responses to cytosolic DNA"/>
            <pathway-xref db="MetaCyc" id="PWY-6378" name="putrebactin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DRE-8849932" name="Synaptic adhesion-like molecules"/>
            <pathway-xref db="Reactome" id="R-MMU-166020" name="Transfer of LPS from LBP carrier to CD14"/>
            <pathway-xref db="Reactome" id="R-DRE-380270" name="Recruitment of mitotic centrosome proteins and complexes"/>
            <pathway-xref db="Reactome" id="R-HSA-8955332" name="Carboxyterminal post-translational modifications of tubulin"/>
            <pathway-xref db="Reactome" id="R-HSA-163125" name="Post-translational modification: synthesis of GPI-anchored proteins"/>
            <pathway-xref db="Reactome" id="R-HSA-975163" name="IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation"/>
            <pathway-xref db="Reactome" id="R-RNO-9696264" name="RND3 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-7738" name="polyacyltrehalose biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-CFA-168138" name="Toll Like Receptor 9 (TLR9) Cascade"/>
            <pathway-xref db="Reactome" id="R-RNO-429947" name="Deadenylation of mRNA"/>
            <pathway-xref db="Reactome" id="R-DDI-392517" name="Rap1 signalling"/>
            <pathway-xref db="Reactome" id="R-HSA-2022870" name="Chondroitin sulfate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8058" name="2-deoxy-D-ribose degradation II"/>
            <pathway-xref db="MetaCyc" id="PWY-7577" name="ferrichrome biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7940" name="lauryl-hydroxychlorobactene glucoside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9026519" name="Activated NTRK2 signals through RAS"/>
            <pathway-xref db="Reactome" id="R-MMU-9026527" name="Activated NTRK2 signals through PLCG1"/>
            <pathway-xref db="Reactome" id="R-MMU-380284" name="Loss of proteins required for interphase microtubule organization from the centrosome"/>
            <pathway-xref db="MetaCyc" id="PWY-5672" name="ginsenosides biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7139" name="sesaminol glucoside biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6039" name="chlorogenic acid biosynthesis I"/>
            <pathway-xref db="MetaCyc" id="PWY-6763" name="salicortin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-159227" name="Transport of the SLBP independent Mature mRNA"/>
            <pathway-xref db="Reactome" id="R-DME-388844" name="Receptor-type tyrosine-protein phosphatases"/>
            <pathway-xref db="MetaCyc" id="PWY-5936" name="xyloglucan biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-9028731" name="Activated NTRK2 signals through FRS2 and FRS3"/>
            <pathway-xref db="MetaCyc" id="PWY-8210" name="pyrrolomycin biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-5292" name="vindoline, vindorosine and vinblastine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-3270619" name="IRF3-mediated induction of type I IFN"/>
            <pathway-xref db="MetaCyc" id="PWY-7367" name="phosphatidylcholine resynthesis via glycerophosphocholine"/>
            <pathway-xref db="Reactome" id="R-MMU-2022923" name="Dermatan sulfate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8039" name="mitomycin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7907" name="(2S,3E)-2-amino-4-methoxy-but-3-enoate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9665737" name="Drug resistance in ERBB2 TMD/JMD mutants"/>
            <pathway-xref db="MetaCyc" id="PWY-7555" name="alpha-cyclopiazonate biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-HSA-9013106" name="RHOC GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-7140" name="myricetin gentiobioside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-5673000" name="RAF activation"/>
            <pathway-xref db="MetaCyc" id="PWY-7735" name="echinomycin and triostin A biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-2022854" name="Keratan sulfate biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-7621" name="autoinducer CAI-1 biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5994" name="palmitate biosynthesis I (type I fatty acid synthase)"/>
            <pathway-xref db="Reactome" id="R-CEL-159236" name="Transport of Mature mRNA derived from an Intron-Containing Transcript"/>
            <pathway-xref db="Reactome" id="R-RNO-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-8047" name="bryostatin biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-6948" name="sitosterol degradation to androstenedione"/>
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            <pathway-xref db="MetaCyc" id="PWY-6525" name="stellariose and mediose biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9665245" name="Resistance of ERBB2 KD mutants to tesevatinib"/>
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            <pathway-xref db="MetaCyc" id="PWY-8241" name="Escherichia coli serotype O:71/Salmonella enterica serotype O:28ac O antigen biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-8251" name="Escherichia coli serotype O:2 O antigen biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-RNO-2024101" name="CS/DS degradation"/>
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            <pathway-xref db="Reactome" id="R-DRE-2022854" name="Keratan sulfate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8133" name="succinoglycan biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-7564" name="bacimethrin and bacimethrin pyrophosphate biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-8272" name="Escherichia coli serotype O:49 O antigen biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7137" name="quercetin gentiotetraside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-9013424" name="RHOV GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-6969" name="TCA cycle V (2-oxoglutarate synthase)"/>
            <pathway-xref db="Reactome" id="R-RNO-5686938" name="Regulation of TLR by endogenous ligand"/>
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            <pathway-xref db="MetaCyc" id="PWY-8252" name="Escherichia coli serotype O:50 O antigen biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8236" name="Salmonella enterica serotype O:39 O antigen biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-MMU-2500257" name="Resolution of Sister Chromatid Cohesion"/>
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            <pathway-xref db="Reactome" id="R-CEL-9615933" name="Postmitotic nuclear pore complex (NPC) reformation"/>
            <pathway-xref db="MetaCyc" id="PWY-7143" name="kaempferol gentiobioside biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-7384" name="anaerobic energy metabolism (invertebrates, mitochondrial)"/>
            <pathway-xref db="MetaCyc" id="PWY-7727" name="docosahexaenoate biosynthesis IV (4-desaturase, mammals)"/>
            <pathway-xref db="Reactome" id="R-HSA-8873719" name="RAB geranylgeranylation"/>
            <pathway-xref db="MetaCyc" id="PWY-6312" name="barbaloin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DDI-5674135" name="MAP2K and MAPK activation"/>
            <pathway-xref db="Reactome" id="R-HSA-216083" name="Integrin cell surface interactions"/>
            <pathway-xref db="MetaCyc" id="PWY-761" name="rhizobactin 1021 biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-1971475" name="A tetrasaccharide linker sequence is required for GAG synthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7673" name="fusarin C biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-209968" name="Thyroxine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7563" name="bassianin and desmethylbassianin biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-7212" name="baicalein metabolism"/>
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            <pathway-xref db="Reactome" id="R-BTA-2022870" name="Chondroitin sulfate biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-DRE-9013406" name="RHOQ GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-1461957" name="Beta defensins"/>
            <pathway-xref db="MetaCyc" id="PWY-7468" name="benzoyl-beta-D-glucopyranose biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-5105" name="hesperitin glycoside biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-CEL-9013406" name="RHOQ GTPase cycle"/>
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            <pathway-xref db="MetaCyc" id="PWY-8157" name="avenanthramide biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-7859" name="jasmonoyl-L-isoleucine inactivation"/>
            <pathway-xref db="MetaCyc" id="PWYG-321" name="mycolate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8084" name="daurichromenate biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-MMU-170984" name="ARMS-mediated activation"/>
            <pathway-xref db="Reactome" id="R-HSA-2243919" name="Crosslinking of collagen fibrils"/>
            <pathway-xref db="Reactome" id="R-DRE-917937" name="Iron uptake and transport"/>
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            <pathway-xref db="MetaCyc" id="PWY-6922" name="L-Ndelta-acetylornithine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5846" name="colchicine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5313" name="superpathway of anthocyanin biosynthesis (from cyanidin and cyanidin 3-O-glucoside)"/>
            <pathway-xref db="Reactome" id="R-HSA-3656243" name="Defective ST3GAL3 causes MCT12 and EIEE15"/>
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            <pathway-xref db="MetaCyc" id="PWY-7946" name="sarcinaxanthin diglucoside biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-DRE-9013148" name="CDC42 GTPase cycle"/>
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            <pathway-xref db="Reactome" id="R-RNO-1474228" name="Degradation of the extracellular matrix"/>
            <pathway-xref db="MetaCyc" id="PWY-7029" name="terminal olefins biosynthesis II"/>
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            <pathway-xref db="Reactome" id="R-DDI-5673001" name="RAF/MAP kinase cascade"/>
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            <pathway-xref db="MetaCyc" id="PWY-5160" name="rose anthocyanin biosynthesis I (via cyanidin 5-O-beta-D-glucoside)"/>
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            <pathway-xref db="MetaCyc" id="PWY-7694" name="zwittermicin A biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-MMU-9013406" name="RHOQ GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-7150" name="polymethylated quercetin glucoside biosynthesis I - quercetin series (Chrysosplenium)"/>
            <pathway-xref db="Reactome" id="R-SPO-159236" name="Transport of Mature mRNA derived from an Intron-Containing Transcript"/>
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            <pathway-xref db="MetaCyc" id="PWY-5139" name="pelargonidin conjugates biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-7819" name="poly(3-O-beta-D-glucopyranosyl-N-acetylgalactosamine 1-phosphate) wall teichoic acid biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-983231" name="Factors involved in megakaryocyte development and platelet production"/>
            <pathway-xref db="MetaCyc" id="PWY-5477" name="gallotannin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-9648025" name="EML4 and NUDC in mitotic spindle formation"/>
            <pathway-xref db="Reactome" id="R-MMU-8980692" name="RHOA GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-977606" name="Regulation of Complement cascade"/>
            <pathway-xref db="MetaCyc" id="PWY-5913" name="partial TCA cycle (obligate autotrophs)"/>
            <pathway-xref db="Reactome" id="R-MMU-8849932" name="Synaptic adhesion-like molecules"/>
            <pathway-xref db="MetaCyc" id="PWY-7599" name="anditomin biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-RNO-5673001" name="RAF/MAP kinase cascade"/>
            <pathway-xref db="MetaCyc" id="PWY-7401" name="crotonate fermentation (to acetate and cyclohexane carboxylate)"/>
            <pathway-xref db="Reactome" id="R-DDI-1660516" name="Synthesis of PIPs at the early endosome membrane"/>
            <pathway-xref db="MetaCyc" id="PWY-6415" name="L-ascorbate biosynthesis V (euglena, D-galacturonate pathway)"/>
            <pathway-xref db="MetaCyc" id="PWY-6679" name="jadomycin biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-MMU-9020702" name="Interleukin-1 signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-7168" name="flavonol acylglucoside biosynthesis I - kaempferol derivatives"/>
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            <pathway-xref db="Reactome" id="R-DME-214844" name="DL and DIF homodimers complexed with CACT are all phosphorylated in the TL receptor 'signalling complex'"/>
            <pathway-xref db="MetaCyc" id="PWY-5822" name="trichloroethene degradation"/>
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            <pathway-xref db="Reactome" id="R-RNO-2022857" name="Keratan sulfate degradation"/>
            <pathway-xref db="Reactome" id="R-RNO-216083" name="Integrin cell surface interactions"/>
            <pathway-xref db="MetaCyc" id="PWY-8000" name="vitamin K degradation"/>
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            <pathway-xref db="MetaCyc" id="PWY-2902" name="cytokinin-O-glucosides biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-7743" name="dimycocerosyl triglycosyl phenolphthiocerol biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-8237" name="Escherichia coli serotype O:1B/Salmonella enterica serotype O:42 O antigen biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-MMU-6804115" name="TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"/>
            <pathway-xref db="Reactome" id="R-MMU-5689901" name="Metalloprotease DUBs"/>
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            <pathway-xref db="Reactome" id="R-MMU-9696264" name="RND3 GTPase cycle"/>
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            <pathway-xref db="Reactome" id="R-GGA-9032759" name="NTRK2 activates RAC1"/>
            <pathway-xref db="Reactome" id="R-HSA-168927" name="TICAM1, RIP1-mediated IKK complex recruitment"/>
            <pathway-xref db="Reactome" id="R-MMU-109704" name="PI3K Cascade"/>
            <pathway-xref db="MetaCyc" id="PWY-6762" name="salicylate glucosides biosynthesis IV"/>
            <pathway-xref db="Reactome" id="R-RNO-388844" name="Receptor-type tyrosine-protein phosphatases"/>
            <pathway-xref db="MetaCyc" id="PWY-5048" name="rosmarinic acid biosynthesis I"/>
            <pathway-xref db="MetaCyc" id="PWY-7897" name="flavonoid di-C-glucosylation"/>
            <pathway-xref db="Reactome" id="R-BTA-114608" name="Platelet degranulation"/>
            <pathway-xref db="Reactome" id="R-HSA-380284" name="Loss of proteins required for interphase microtubule organization from the centrosome"/>
            <pathway-xref db="MetaCyc" id="PWY-8055" name="palmitoyl ethanolamide biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DRE-2022857" name="Keratan sulfate degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7539" name="6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia)"/>
            <pathway-xref db="Reactome" id="R-DDI-983231" name="Factors involved in megakaryocyte development and platelet production"/>
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            <pathway-xref db="MetaCyc" id="PWY-7450" name="anthocyanidin modification (Arabidopsis)"/>
            <pathway-xref db="MetaCyc" id="PWY-5469" name="sesamin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5926" name="afrormosin conjugates interconversion"/>
            <pathway-xref db="MetaCyc" id="PWY-7354" name="aclacinomycin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7145" name="genistin gentiobioside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-975163" name="IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation"/>
            <pathway-xref db="MetaCyc" id="PWY-8205" name="Escherichia coli serotype O:77/Salmonella enterica serotype O:6,14 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-72163" name="mRNA Splicing - Major Pathway"/>
            <pathway-xref db="MetaCyc" id="PWY-5268" name="salvianin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-2022923" name="Dermatan sulfate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-1810476" name="RIP-mediated NFkB activation via ZBP1"/>
            <pathway-xref db="Reactome" id="R-RNO-1679131" name="Trafficking and processing of endosomal TLR"/>
            <pathway-xref db="Reactome" id="R-DRE-2565942" name="Regulation of PLK1 Activity at G2/M Transition"/>
            <pathway-xref db="MetaCyc" id="PWY-7656" name="Spodoptera littoralis pheromone biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6453" name="stigma estolide biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-3560801" name="Defective B3GAT3 causes JDSSDHD"/>
            <pathway-xref db="MetaCyc" id="PWY-8234" name="Escherichia coli serotype O:183/Shigella boydii serotype O:10 O antigen biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7692" name="bikaverin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7811" name="6-methylpretetramide biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6920" name="6-gingerol analog biosynthesis (engineered)"/>
            <pathway-xref db="Reactome" id="R-HSA-5602566" name="TICAM1 deficiency - HSE"/>
            <pathway-xref db="MetaCyc" id="PWY-7602" name="icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)"/>
            <pathway-xref db="Reactome" id="R-CFA-2022923" name="Dermatan sulfate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-168638" name="NOD1/2 Signaling Pathway"/>
            <pathway-xref db="Reactome" id="R-SSC-1679131" name="Trafficking and processing of endosomal TLR"/>
            <pathway-xref db="MetaCyc" id="PWY-7988" name="baumannoferrin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SSC-109704" name="PI3K Cascade"/>
            <pathway-xref db="MetaCyc" id="PWY-6147" name="6-hydroxymethyl-dihydropterin diphosphate biosynthesis I"/>
            <pathway-xref db="MetaCyc" id="PWY-7687" name="stipitatate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5757" name="fosfomycin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6379" name="alcaligin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7074" name="phenylethanol glycoconjugate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CFA-1679131" name="Trafficking and processing of endosomal TLR"/>
            <pathway-xref db="MetaCyc" id="PWY-7206" name="pyrimidine deoxyribonucleotides dephosphorylation"/>
            <pathway-xref db="Reactome" id="R-RNO-159227" name="Transport of the SLBP independent Mature mRNA"/>
            <pathway-xref db="Reactome" id="R-HSA-8951664" name="Neddylation"/>
            <pathway-xref db="MetaCyc" id="PWY-7730" name="T-2 toxin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DDI-5673000" name="RAF activation"/>
            <pathway-xref db="MetaCyc" id="PWY-8204" name="Salmonella enterica serotype O:54 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-5603037" name="IRAK4 deficiency (TLR5)"/>
            <pathway-xref db="MetaCyc" id="PWY-6930" name="phenolic malonylglucosides biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6627" name="salinosporamide A biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7213" name="wogonin metabolism"/>
            <pathway-xref db="Reactome" id="R-DDI-5675221" name="Negative regulation of MAPK pathway"/>
            <pathway-xref db="Reactome" id="R-MMU-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-CEL-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="MetaCyc" id="PWY-7405" name="aurachin RE biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6657" name="polyhydroxydecanoate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6024" name="isovitexin glycosides biosynthesis"/>
            <pathway-xref db="Reactome" id="R-XTR-2243919" name="Crosslinking of collagen fibrils"/>
            <pathway-xref db="MetaCyc" id="PWY-8242" name="Escherichia coli serotype O:51/Salmonella enterica serotype O:57 O antigen biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5666" name="alpha-solanine/alpha-chaconine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-380320" name="Recruitment of NuMA to mitotic centrosomes"/>
            <pathway-xref db="Reactome" id="R-HSA-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-9025046" name="NTF3 activates NTRK2 (TRKB) signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-3000178" name="ECM proteoglycans"/>
            <pathway-xref db="Reactome" id="R-HSA-446388" name="Regulation of cytoskeletal remodeling and cell spreading by IPP complex components"/>
            <pathway-xref db="Reactome" id="R-MMU-166166" name="MyD88-independent TLR4 cascade"/>
            <pathway-xref db="Reactome" id="R-MMU-9603381" name="Activated NTRK3 signals through PI3K"/>
            <pathway-xref db="MetaCyc" id="PWY-7838" name="globo-series glycosphingolipids biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7633" name="calycosin 7-O-glucoside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-9013423" name="RAC3 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-917937" name="Iron uptake and transport"/>
            <pathway-xref db="Reactome" id="R-MMU-9013149" name="RAC1 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-7984" name="acinetobactin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-5689896" name="Ovarian tumor domain proteases"/>
            <pathway-xref db="MetaCyc" id="PWY-5321" name="quercetin glycoside biosynthesis (Arabidopsis)"/>
            <pathway-xref db="MetaCyc" id="PWY-8235" name="Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-418555" name="G alpha (s) signalling events"/>
          </entry>
          <signature-library-release library="PROSITE_PROFILES" version="2021_01"/>
        </signature>
        <model-ac>PS51450</model-ac>
        <locations>
          <profilescan-location score="7.33462" start="156" end="178">
            <location-fragments>
              <profilescan-location-fragment start="156" end="178" dc-status="CONTINUOUS"/>
            </location-fragments>
            <alignment>KLKILELRENNLTSLPkSLSRLE</alignment>
          </profilescan-location>
        </locations>
      </profilescan-match>
      <superfamilyhmmer3-match evalue="4.93E-29">
        <signature ac="SSF52058" name="L domain-like">
          <signature-library-release library="SUPERFAMILY" version="1.75"/>
        </signature>
        <model-ac>0048059</model-ac>
        <locations>
          <superfamilyhmmer3-location hmm-length="266" start="16" end="174">
            <location-fragments>
              <superfamilyhmmer3-location-fragment start="16" end="174" dc-status="CONTINUOUS"/>
            </location-fragments>
          </superfamilyhmmer3-location>
        </locations>
      </superfamilyhmmer3-match>
      <superfamilyhmmer3-match evalue="8.84E-53">
        <signature ac="SSF52058" name="L domain-like">
          <signature-library-release library="SUPERFAMILY" version="1.75"/>
        </signature>
        <model-ac>0048505</model-ac>
        <locations>
          <superfamilyhmmer3-location hmm-length="384" start="134" end="397">
            <location-fragments>
              <superfamilyhmmer3-location-fragment start="134" end="397" dc-status="CONTINUOUS"/>
            </location-fragments>
          </superfamilyhmmer3-location>
        </locations>
      </superfamilyhmmer3-match>
    </matches>
  </protein>
  <protein>
    <sequence md5="e487ac06129527a15aabb03d946b8885">KCDFVSDARSLVLPLTPNPGVPRTCPSMSPALSSVEMVAEYTSLFAQCFSPDGQLLAVGNHLGKIVIYSLEQIVQRSRGEVVTDETPTQAAQLSSTSSYFCQFWAKETKKPILSLISNPDHLIIGTQGEISGWTWAGIRKKSPKQAWSLPLPRQPGTAIETDANYLALNSSPQTAGHLIVAGGDHHVHVYDLETRLSVMDLRGHSNYVHSVSHCPQSNMIASASEDGSVRLWDVRRKNSNTSTLVPSDKEPLCRPSLGKWMGAVSLNSDWLACGGGPRAAVWHLRTMSPNEALPPDENGVHEIKIQGDRVLIGGQMNMLYQANLSGEVQSVVPVSSSCIYSIICQEAPIRILTCSGSSSKIDVCAPNFSYKDQTIAFPI</sequence>
    <xref id="TCALIF_00330-PA" name="TCALIF_00330-PA protein Name:&quot;Similar to thoc6 THO complex subunit 6 homolog (Danio rerio)&quot; AED:0.07 eAED:0.07 QI:46|1|1|1|1|1|7|85|379"/>
    <matches>
      <hmmer2-match evalue="3.7E-13" score="59.7">
        <signature ac="SM00320" name="WD40_4">
          <entry ac="IPR001680" desc="WD40 repeat" name="WD40_repeat" type="REPEAT">
            <go-xref category="MOLECULAR_FUNCTION" db="GO" id="GO:0005515" name="protein binding"/>
            <pathway-xref db="Reactome" id="R-DME-674695" name="RNA Polymerase II Pre-transcription Events"/>
            <pathway-xref db="Reactome" id="R-HSA-9610379" name="HCMV Late Events"/>
            <pathway-xref db="Reactome" id="R-RNO-3301854" name="Nuclear Pore Complex (NPC) Disassembly"/>
            <pathway-xref db="Reactome" id="R-HSA-4615885" name="SUMOylation of DNA replication proteins"/>
            <pathway-xref db="Reactome" id="R-HSA-6803207" name="TP53 Regulates Transcription of Caspase Activators and Caspases"/>
            <pathway-xref db="Reactome" id="R-HSA-2565942" name="Regulation of PLK1 Activity at G2/M Transition"/>
            <pathway-xref db="Reactome" id="R-DME-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-GGA-1632852" name="Macroautophagy"/>
            <pathway-xref db="MetaCyc" id="PWY-6363" name="D-myo-inositol (1,4,5)-trisphosphate degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-6791226" name="Major pathway of rRNA processing in the nucleolus and cytosol"/>
            <pathway-xref db="Reactome" id="R-BTA-5628897" name="TP53 Regulates Metabolic Genes"/>
            <pathway-xref db="Reactome" id="R-MMU-5620912" name="Anchoring of the basal body to the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-MMU-2565942" name="Regulation of PLK1 Activity at G2/M Transition"/>
            <pathway-xref db="Reactome" id="R-DME-9639288" name="Amino acids regulate mTORC1"/>
            <pathway-xref db="Reactome" id="R-MMU-6811434" name="COPI-dependent Golgi-to-ER retrograde traffic"/>
            <pathway-xref db="Reactome" id="R-CFA-6814122" name="Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"/>
            <pathway-xref db="Reactome" id="R-SCE-9696273" name="RND1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-5620912" name="Anchoring of the basal body to the plasma membrane"/>
            <pathway-xref db="Reactome" id="R-MMU-6791226" name="Major pathway of rRNA processing in the nucleolus and cytosol"/>
            <pathway-xref db="Reactome" id="R-DRE-5620924" name="Intraflagellar transport"/>
            <pathway-xref db="Reactome" id="R-MMU-5674135" name="MAP2K and MAPK activation"/>
            <pathway-xref db="Reactome" id="R-GGA-5696400" name="Dual Incision in GG-NER"/>
            <pathway-xref db="Reactome" id="R-RNO-6804757" name="Regulation of TP53 Degradation"/>
            <pathway-xref db="Reactome" id="R-DRE-159227" name="Transport of the SLBP independent Mature mRNA"/>
            <pathway-xref db="Reactome" id="R-MMU-171319" name="Telomere Extension By Telomerase"/>
            <pathway-xref db="Reactome" id="R-DDI-9013149" name="RAC1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DRE-5663220" name="RHO GTPases Activate Formins"/>
            <pathway-xref db="Reactome" id="R-DRE-5696394" name="DNA Damage Recognition in GG-NER"/>
            <pathway-xref db="Reactome" id="R-BTA-3214841" name="PKMTs methylate histone lysines"/>
            <pathway-xref db="Reactome" id="R-SPO-1257604" name="PIP3 activates AKT signaling"/>
            <pathway-xref db="Reactome" id="R-DME-209461" name="Ubiquitination and degradation of phosphorylated ARM"/>
            <pathway-xref db="Reactome" id="R-DDI-179409" name="APC-Cdc20 mediated degradation of Nek2A"/>
            <pathway-xref db="Reactome" id="R-HSA-1660514" name="Synthesis of PIPs at the Golgi membrane"/>
            <pathway-xref db="Reactome" id="R-MMU-4615885" name="SUMOylation of DNA replication proteins"/>
            <pathway-xref db="Reactome" id="R-HSA-997272" name="Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits"/>
            <pathway-xref db="Reactome" id="R-DDI-5628897" name="TP53 Regulates Metabolic Genes"/>
            <pathway-xref db="Reactome" id="R-SPO-75955" name="RNA Polymerase II Transcription Elongation"/>
            <pathway-xref db="Reactome" id="R-SCE-72702" name="Ribosomal scanning and start codon recognition"/>
            <pathway-xref db="Reactome" id="R-RNO-380270" name="Recruitment of mitotic centrosome proteins and complexes"/>
            <pathway-xref db="Reactome" id="R-DME-72649" name="Translation initiation complex formation"/>
            <pathway-xref db="Reactome" id="R-DME-500657" name="Presynaptic function of Kainate receptors"/>
            <pathway-xref db="Reactome" id="R-MMU-8964616" name="G beta:gamma signalling through CDC42"/>
            <pathway-xref db="Reactome" id="R-DRE-9013407" name="RHOH GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DRE-9018519" name="Estrogen-dependent gene expression"/>
            <pathway-xref db="Reactome" id="R-MMU-420092" name="Glucagon-type ligand receptors"/>
            <pathway-xref db="Reactome" id="R-HSA-400253" name="Circadian Clock"/>
            <pathway-xref db="Reactome" id="R-HSA-8964616" name="G beta:gamma signalling through CDC42"/>
            <pathway-xref db="Reactome" id="R-BTA-2029482" name="Regulation of actin dynamics for phagocytic cup formation"/>
            <pathway-xref db="Reactome" id="R-DRE-72689" name="Formation of a pool of free 40S subunits"/>
            <pathway-xref db="Reactome" id="R-DRE-3371571" name="HSF1-dependent transactivation"/>
            <pathway-xref db="Reactome" id="R-CEL-202040" name="G-protein activation"/>
            <pathway-xref db="Reactome" id="R-SPO-8856828" name="Clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-SCE-3371571" name="HSF1-dependent transactivation"/>
            <pathway-xref db="Reactome" id="R-MMU-72163" name="mRNA Splicing - Major Pathway"/>
            <pathway-xref db="Reactome" id="R-DDI-1660517" name="Synthesis of PIPs at the late endosome membrane"/>
            <pathway-xref db="Reactome" id="R-SPO-9696270" name="RND2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-191859" name="snRNP Assembly"/>
            <pathway-xref db="Reactome" id="R-SPO-176407" name="Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase"/>
            <pathway-xref db="Reactome" id="R-DRE-6814122" name="Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding"/>
            <pathway-xref db="Reactome" id="R-SSC-176407" name="Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase"/>
            <pathway-xref db="Reactome" id="R-DRE-392170" name="ADP signalling through P2Y purinoceptor 12"/>
            <pathway-xref db="Reactome" id="R-HSA-1368108" name="BMAL1:CLOCK,NPAS2 activates circadian gene expression"/>
            <pathway-xref db="Reactome" id="R-HSA-6811434" name="COPI-dependent Golgi-to-ER retrograde traffic"/>
            <pathway-xref db="Reactome" id="R-MMU-141405" name="Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components"/>
            <pathway-xref db="Reactome" id="R-SCE-975957" name="Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"/>
            <pathway-xref db="Reactome" id="R-HSA-5674135" name="MAP2K and MAPK activation"/>
            <pathway-xref db="Reactome" id="R-HSA-72689" name="Formation of a pool of free 40S subunits"/>
            <pathway-xref db="Reactome" id="R-HSA-5610780" name="Degradation of GLI1 by the proteasome"/>
            <pathway-xref db="Reactome" id="R-HSA-390471" name="Association of TriC/CCT with target proteins during biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DDI-2029482" name="Regulation of actin dynamics for phagocytic cup formation"/>
            <pathway-xref db="Reactome" id="R-DME-209440" name="Recruitment of the 'destruction complex' to the receptor complex, the degradation of AXN and release of ARM"/>
            <pathway-xref db="Reactome" id="R-SCE-73776" name="RNA Polymerase II Promoter Escape"/>
            <pathway-xref db="Reactome" id="R-DRE-6804758" name="Regulation of TP53 Activity through Acetylation"/>
            <pathway-xref db="Reactome" id="R-SCE-156827" name="L13a-mediated translational silencing of Ceruloplasmin expression"/>
            <pathway-xref db="Reactome" id="R-DRE-3232142" name="SUMOylation of ubiquitinylation proteins"/>
            <pathway-xref db="Reactome" id="R-SPO-9615933" name="Postmitotic nuclear pore complex (NPC) reformation"/>
            <pathway-xref db="Reactome" id="R-RNO-9648025" name="EML4 and NUDC in mitotic spindle formation"/>
            <pathway-xref db="Reactome" id="R-MMU-1660514" name="Synthesis of PIPs at the Golgi membrane"/>
            <pathway-xref db="Reactome" id="R-HSA-171319" name="Telomere Extension By Telomerase"/>
            <pathway-xref db="Reactome" id="R-DRE-3108214" name="SUMOylation of DNA damage response and repair proteins"/>
            <pathway-xref db="Reactome" id="R-DDI-9033241" name="Peroxisomal protein import"/>
            <pathway-xref db="Reactome" id="R-DME-6807878" name="COPI-mediated anterograde transport"/>
            <pathway-xref db="Reactome" id="R-MMU-2871837" name="FCERI mediated NF-kB activation"/>
            <pathway-xref db="Reactome" id="R-MMU-975957" name="Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)"/>
            <pathway-xref db="Reactome" id="R-DRE-380972" name="Energy dependent regulation of mTOR by LKB1-AMPK"/>
            <pathway-xref db="Reactome" id="R-MMU-174084" name="Autodegradation of Cdh1 by Cdh1:APC/C"/>
            <pathway-xref db="Reactome" id="R-BTA-606279" name="Deposition of new CENPA-containing nucleosomes at the centromere"/>
            <pathway-xref db="Reactome" id="R-CEL-418597" name="G alpha (z) signalling events"/>
            <pathway-xref db="MetaCyc" id="PWY-7831" name="ABH and Lewis epitopes biosynthesis from type 2 precursor disaccharide"/>
            <pathway-xref db="Reactome" id="R-HSA-4085377" name="SUMOylation of SUMOylation proteins"/>
            <pathway-xref db="Reactome" id="R-HSA-420092" name="Glucagon-type ligand receptors"/>
            <pathway-xref db="Reactome" id="R-DME-2995383" name="Initiation of Nuclear Envelope (NE) Reformation"/>
            <pathway-xref db="Reactome" id="R-RNO-9696273" name="RND1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-GGA-5696395" name="Formation of Incision Complex in GG-NER"/>
            <pathway-xref db="Reactome" id="R-SPO-389357" name="CD28 dependent PI3K/Akt signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-5620924" name="Intraflagellar transport"/>
            <pathway-xref db="Reactome" id="R-DDI-72689" name="Formation of a pool of free 40S subunits"/>
            <pathway-xref db="Reactome" id="R-SSC-141430" name="Inactivation of APC/C via direct inhibition of the APC/C complex"/>
            <pathway-xref db="Reactome" id="R-HSA-174154" name="APC/C:Cdc20 mediated degradation of Securin"/>
            <pathway-xref db="Reactome" id="R-RNO-2173788" name="Downregulation of TGF-beta receptor signaling"/>
            <pathway-xref db="Reactome" id="R-DRE-3301854" name="Nuclear Pore Complex (NPC) Disassembly"/>
            <pathway-xref db="Reactome" id="R-MMU-9615933" name="Postmitotic nuclear pore complex (NPC) reformation"/>
            <pathway-xref db="Reactome" id="R-CEL-201722" name="Formation of the beta-catenin:TCF transactivating complex"/>
            <pathway-xref db="Reactome" id="R-RNO-5218920" name="VEGFR2 mediated vascular permeability"/>
            <pathway-xref db="Reactome" id="R-HSA-5626978" name="TNFR1-mediated ceramide production"/>
            <pathway-xref db="Reactome" id="R-RNO-8936459" name="RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function"/>
            <pathway-xref db="Reactome" id="R-SPO-72706" name="GTP hydrolysis and joining of the 60S ribosomal subunit"/>
            <pathway-xref db="Reactome" id="R-SCE-141405" name="Inhibition of the proteolytic activity of APC/C required for the onset of anaphase by mitotic spindle checkpoint components"/>
            <pathway-xref db="Reactome" id="R-SPO-5578749" name="Transcriptional regulation by small RNAs"/>
            <pathway-xref db="Reactome" id="R-MMU-1296041" name="Activation of G protein gated Potassium channels"/>
            <pathway-xref db="Reactome" id="R-HSA-2465910" name="MASTL Facilitates Mitotic Progression"/>
            <pathway-xref db="Reactome" id="R-HSA-156827" name="L13a-mediated translational silencing of Ceruloplasmin expression"/>
            <pathway-xref db="Reactome" id="R-CFA-392170" name="ADP signalling through P2Y purinoceptor 12"/>
            <pathway-xref db="Reactome" id="R-MMU-72187" name="mRNA 3'-end processing"/>
            <pathway-xref db="Reactome" id="R-DDI-75955" name="RNA Polymerase II Transcription Elongation"/>
            <pathway-xref db="Reactome" id="R-DDI-6782135" name="Dual incision in TC-NER"/>
            <pathway-xref db="Reactome" id="R-GGA-110314" name="Recognition of DNA damage by PCNA-containing replication complex"/>
            <pathway-xref db="Reactome" id="R-MMU-1655829" name="Regulation of cholesterol biosynthesis by SREBP (SREBF)"/>
            <pathway-xref db="Reactome" id="R-MMU-68877" name="Mitotic Prometaphase"/>
            <pathway-xref db="Reactome" id="R-HSA-5696395" name="Formation of Incision Complex in GG-NER"/>
            <pathway-xref db="Reactome" id="R-DDI-380972" name="Energy dependent regulation of mTOR by LKB1-AMPK"/>
            <pathway-xref db="Reactome" id="R-XTR-2559580" name="Oxidative Stress Induced Senescence"/>
            <pathway-xref db="Reactome" id="R-HSA-195253" name="Degradation of beta-catenin by the destruction complex"/>
            <pathway-xref db="Reactome" id="R-MMU-430039" name="mRNA decay by 5' to 3' exoribonuclease"/>
            <pathway-xref db="Reactome" id="R-MMU-8951664" name="Neddylation"/>
            <pathway-xref db="Reactome" id="R-RNO-111458" name="Formation of apoptosome"/>
            <pathway-xref db="Reactome" id="R-CEL-381753" name="Olfactory Signaling Pathway"/>
            <pathway-xref db="Reactome" id="R-HSA-1655829" name="Regulation of cholesterol biosynthesis by SREBP (SREBF)"/>
            <pathway-xref db="Reactome" id="R-HSA-9013418" name="RHOBTB2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-RNO-159230" name="Transport of the SLBP Dependant Mature mRNA"/>
            <pathway-xref db="Reactome" id="R-HSA-174048" name="APC/C:Cdc20 mediated degradation of Cyclin B"/>
            <pathway-xref db="Reactome" id="R-HSA-8943724" name="Regulation of PTEN gene transcription"/>
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        <model-ac>4d0kA01</model-ac>
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            <pathway-xref db="Reactome" id="R-MMU-983189" name="Kinesins"/>
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            <pathway-xref db="Reactome" id="R-CFA-381753" name="Olfactory Signaling Pathway"/>
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            <pathway-xref db="Reactome" id="R-DRE-5628897" name="TP53 Regulates Metabolic Genes"/>
            <pathway-xref db="Reactome" id="R-DME-110314" name="Recognition of DNA damage by PCNA-containing replication complex"/>
            <pathway-xref db="Reactome" id="R-RNO-5663220" name="RHO GTPases Activate Formins"/>
            <pathway-xref db="Reactome" id="R-DME-4615885" name="SUMOylation of DNA replication proteins"/>
            <pathway-xref db="Reactome" id="R-MMU-400042" name="Adrenaline,noradrenaline inhibits insulin secretion"/>
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            <pathway-xref db="Reactome" id="R-MMU-500657" name="Presynaptic function of Kainate receptors"/>
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            <pathway-xref db="Reactome" id="R-RNO-389357" name="CD28 dependent PI3K/Akt signaling"/>
            <pathway-xref db="Reactome" id="R-SPO-6804757" name="Regulation of TP53 Degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-166208" name="mTORC1-mediated signalling"/>
            <pathway-xref db="Reactome" id="R-HSA-9020702" name="Interleukin-1 signaling"/>
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            <pathway-xref db="Reactome" id="R-DRE-380259" name="Loss of Nlp from mitotic centrosomes"/>
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            <pathway-xref db="Reactome" id="R-CFA-392451" name="G beta:gamma signalling through PI3Kgamma"/>
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            <pathway-xref db="Reactome" id="R-SPO-204005" name="COPII-mediated vesicle transport"/>
            <pathway-xref db="Reactome" id="R-MMU-8953750" name="Transcriptional Regulation by E2F6"/>
            <pathway-xref db="Reactome" id="R-XTR-212300" name="PRC2 methylates histones and DNA"/>
            <pathway-xref db="Reactome" id="R-DRE-416476" name="G alpha (q) signalling events"/>
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            <pathway-xref db="Reactome" id="R-DDI-6791226" name="Major pathway of rRNA processing in the nucleolus and cytosol"/>
            <pathway-xref db="Reactome" id="R-MMU-72165" name="mRNA Splicing - Minor Pathway"/>
            <pathway-xref db="Reactome" id="R-MMU-212300" name="PRC2 methylates histones and DNA"/>
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            <pathway-xref db="Reactome" id="R-MMU-418555" name="G alpha (s) signalling events"/>
          </entry>
          <signature-library-release library="PROSITE_PATTERNS" version="2021_01"/>
        </signature>
        <model-ac>PS00678</model-ac>
        <locations>
          <patternscan-location level="STRONG" start="220" end="234">
            <location-fragments>
              <patternscan-location-fragment start="220" end="234" dc-status="CONTINUOUS"/>
            </location-fragments>
            <alignment>IASAseDgSVRLWDV</alignment>
          </patternscan-location>
        </locations>
      </patternscan-match>
      <profilescan-match>
        <signature ac="PS50082" desc="Trp-Asp (WD) repeats profile." name="WD_REPEATS_2">
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        </signature>
        <model-ac>PS50082</model-ac>
        <locations>
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            <location-fragments>
              <profilescan-location-fragment start="201" end="242" dc-status="CONTINUOUS"/>
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            <alignment>LRGHSNYVHSVSHCPQSNMIASASEDGSVRLWDVRRKNSNTS</alignment>
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        </locations>
      </profilescan-match>
      <profilescan-match>
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            </location-fragments>
            <alignment>LRGHSNYVHSVSHCPQSNMIASASEDGSVRLWDVR-------</alignment>
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        </locations>
      </profilescan-match>
      <superfamilyhmmer3-match evalue="1.36E-30">
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            <pathway-xref db="Reactome" id="R-HSA-5684264" name="MAP3K8 (TPL2)-dependent MAPK1/3 activation"/>
            <pathway-xref db="Reactome" id="R-SPO-674695" name="RNA Polymerase II Pre-transcription Events"/>
            <pathway-xref db="Reactome" id="R-CEL-8953750" name="Transcriptional Regulation by E2F6"/>
            <pathway-xref db="Reactome" id="R-HSA-9609690" name="HCMV Early Events"/>
            <pathway-xref db="Reactome" id="R-DME-166208" name="mTORC1-mediated signalling"/>
            <pathway-xref db="Reactome" id="R-RNO-392451" name="G beta:gamma signalling through PI3Kgamma"/>
            <pathway-xref db="Reactome" id="R-DME-418555" name="G alpha (s) signalling events"/>
            <pathway-xref db="Reactome" id="R-HSA-168638" name="NOD1/2 Signaling Pathway"/>
            <pathway-xref db="Reactome" id="R-DDI-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-DRE-202040" name="G-protein activation"/>
            <pathway-xref db="Reactome" id="R-SPO-156827" name="L13a-mediated translational silencing of Ceruloplasmin expression"/>
            <pathway-xref db="Reactome" id="R-HSA-9696270" name="RND2 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-SSC-68877" name="Mitotic Prometaphase"/>
            <pathway-xref db="Reactome" id="R-HSA-3214858" name="RMTs methylate histone arginines"/>
            <pathway-xref db="Reactome" id="R-MMU-193648" name="NRAGE signals death through JNK"/>
            <pathway-xref db="Reactome" id="R-DME-392170" name="ADP signalling through P2Y purinoceptor 12"/>
            <pathway-xref db="Reactome" id="R-MMU-2559582" name="Senescence-Associated Secretory Phenotype (SASP)"/>
            <pathway-xref db="Reactome" id="R-GGA-380270" name="Recruitment of mitotic centrosome proteins and complexes"/>
            <pathway-xref db="Reactome" id="R-HSA-9696264" name="RND3 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-9696273" name="RND1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-CEL-212300" name="PRC2 methylates histones and DNA"/>
            <pathway-xref db="Reactome" id="R-RNO-159227" name="Transport of the SLBP independent Mature mRNA"/>
            <pathway-xref db="Reactome" id="R-HSA-8951664" name="Neddylation"/>
            <pathway-xref db="Reactome" id="R-RNO-6811436" name="COPI-independent Golgi-to-ER retrograde traffic"/>
            <pathway-xref db="Reactome" id="R-DME-72689" name="Formation of a pool of free 40S subunits"/>
            <pathway-xref db="Reactome" id="R-RNO-4641265" name="Repression of WNT target genes"/>
            <pathway-xref db="Reactome" id="R-MMU-4570464" name="SUMOylation of RNA binding proteins"/>
            <pathway-xref db="Reactome" id="R-MMU-73776" name="RNA Polymerase II Promoter Escape"/>
            <pathway-xref db="Reactome" id="R-DME-209413" name="Assembly of the 'destruction complex'"/>
            <pathway-xref db="Reactome" id="R-CEL-456926" name="Thrombin signalling through proteinase activated receptors (PARs)"/>
            <pathway-xref db="Reactome" id="R-DME-3301854" name="Nuclear Pore Complex (NPC) Disassembly"/>
            <pathway-xref db="Reactome" id="R-HSA-4570464" name="SUMOylation of RNA binding proteins"/>
            <pathway-xref db="Reactome" id="R-CEL-3214815" name="HDACs deacetylate histones"/>
            <pathway-xref db="Reactome" id="R-HSA-430039" name="mRNA decay by 5' to 3' exoribonuclease"/>
            <pathway-xref db="Reactome" id="R-MMU-6783310" name="Fanconi Anemia Pathway"/>
            <pathway-xref db="Reactome" id="R-MMU-9646399" name="Aggrephagy"/>
            <pathway-xref db="Reactome" id="R-RNO-3928662" name="EPHB-mediated forward signaling"/>
            <pathway-xref db="Reactome" id="R-DDI-69273" name="Cyclin A/B1/B2 associated events during G2/M transition"/>
            <pathway-xref db="Reactome" id="R-MMU-400206" name="Regulation of lipid metabolism by PPARalpha"/>
            <pathway-xref db="Reactome" id="R-HSA-2871837" name="FCERI mediated NF-kB activation"/>
            <pathway-xref db="Reactome" id="R-HSA-1266695" name="Interleukin-7 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-3214847" name="HATs acetylate histones"/>
            <pathway-xref db="Reactome" id="R-HSA-9646399" name="Aggrephagy"/>
            <pathway-xref db="Reactome" id="R-HSA-141444" name="Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal"/>
            <pathway-xref db="Reactome" id="R-DDI-5696394" name="DNA Damage Recognition in GG-NER"/>
            <pathway-xref db="Reactome" id="R-HSA-432040" name="Vasopressin regulates renal water homeostasis via Aquaporins"/>
            <pathway-xref db="Reactome" id="R-HSA-9013149" name="RAC1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-983189" name="Kinesins"/>
            <pathway-xref db="Reactome" id="R-SCE-141430" name="Inactivation of APC/C via direct inhibition of the APC/C complex"/>
            <pathway-xref db="Reactome" id="R-CFA-381753" name="Olfactory Signaling Pathway"/>
            <pathway-xref db="Reactome" id="R-HSA-8866654" name="E3 ubiquitin ligases ubiquitinate target proteins"/>
            <pathway-xref db="Reactome" id="R-SPO-8951664" name="Neddylation"/>
            <pathway-xref db="Reactome" id="R-DRE-3769402" name="Deactivation of the beta-catenin transactivating complex"/>
            <pathway-xref db="Reactome" id="R-MMU-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="Reactome" id="R-DRE-72706" name="GTP hydrolysis and joining of the 60S ribosomal subunit"/>
            <pathway-xref db="Reactome" id="R-HSA-9615933" name="Postmitotic nuclear pore complex (NPC) reformation"/>
            <pathway-xref db="Reactome" id="R-HSA-3214815" name="HDACs deacetylate histones"/>
            <pathway-xref db="Reactome" id="R-SPO-69656" name="Cyclin A:Cdk2-associated events at S phase entry"/>
            <pathway-xref db="Reactome" id="R-HSA-176407" name="Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase"/>
            <pathway-xref db="Reactome" id="R-DME-110314" name="Recognition of DNA damage by PCNA-containing replication complex"/>
            <pathway-xref db="Reactome" id="R-RNO-5663220" name="RHO GTPases Activate Formins"/>
            <pathway-xref db="Reactome" id="R-DME-4615885" name="SUMOylation of DNA replication proteins"/>
            <pathway-xref db="Reactome" id="R-HSA-6811438" name="Intra-Golgi traffic"/>
            <pathway-xref db="Reactome" id="R-HSA-427413" name="NoRC negatively regulates rRNA expression"/>
            <pathway-xref db="Reactome" id="R-MMU-400042" name="Adrenaline,noradrenaline inhibits insulin secretion"/>
            <pathway-xref db="Reactome" id="R-RNO-1296041" name="Activation of G protein gated Potassium channels"/>
            <pathway-xref db="Reactome" id="R-HSA-8953750" name="Transcriptional Regulation by E2F6"/>
            <pathway-xref db="Reactome" id="R-HSA-9636383" name="Prevention of phagosomal-lysosomal fusion"/>
            <pathway-xref db="Reactome" id="R-HSA-9013420" name="RHOU GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-1169091" name="Activation of NF-kappaB in B cells"/>
            <pathway-xref db="Reactome" id="R-DDI-156827" name="L13a-mediated translational silencing of Ceruloplasmin expression"/>
            <pathway-xref db="Reactome" id="R-HSA-180910" name="Vpr-mediated nuclear import of PICs"/>
            <pathway-xref db="Reactome" id="R-HSA-73863" name="RNA Polymerase I Transcription Termination"/>
            <pathway-xref db="Reactome" id="R-DME-5578749" name="Transcriptional regulation by small RNAs"/>
            <pathway-xref db="MetaCyc" id="PWY-7815" name="poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)"/>
            <pathway-xref db="Reactome" id="R-MMU-174048" name="APC/C:Cdc20 mediated degradation of Cyclin B"/>
            <pathway-xref db="Reactome" id="R-RNO-72689" name="Formation of a pool of free 40S subunits"/>
            <pathway-xref db="Reactome" id="R-RNO-416476" name="G alpha (q) signalling events"/>
            <pathway-xref db="Reactome" id="R-HSA-6790901" name="rRNA modification in the nucleus and cytosol"/>
            <pathway-xref db="Reactome" id="R-HSA-2894862" name="Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants"/>
            <pathway-xref db="Reactome" id="R-RNO-159236" name="Transport of Mature mRNA derived from an Intron-Containing Transcript"/>
            <pathway-xref db="Reactome" id="R-HSA-380320" name="Recruitment of NuMA to mitotic centrosomes"/>
            <pathway-xref db="Reactome" id="R-BTA-8943724" name="Regulation of PTEN gene transcription"/>
            <pathway-xref db="Reactome" id="R-DDI-3214858" name="RMTs methylate histone arginines"/>
            <pathway-xref db="Reactome" id="R-MMU-174154" name="APC/C:Cdc20 mediated degradation of Securin"/>
            <pathway-xref db="Reactome" id="R-HSA-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-75953" name="RNA Polymerase II Transcription Initiation"/>
            <pathway-xref db="Reactome" id="R-GGA-8951664" name="Neddylation"/>
            <pathway-xref db="Reactome" id="R-RNO-171319" name="Telomere Extension By Telomerase"/>
            <pathway-xref db="Reactome" id="R-GGA-5696394" name="DNA Damage Recognition in GG-NER"/>
            <pathway-xref db="Reactome" id="R-MMU-8866654" name="E3 ubiquitin ligases ubiquitinate target proteins"/>
            <pathway-xref db="Reactome" id="R-SPO-76066" name="RNA Polymerase III Transcription Initiation From Type 2 Promoter"/>
            <pathway-xref db="Reactome" id="R-MMU-500657" name="Presynaptic function of Kainate receptors"/>
            <pathway-xref db="Reactome" id="R-HSA-427389" name="ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression"/>
            <pathway-xref db="Reactome" id="R-SPO-6804757" name="Regulation of TP53 Degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-166208" name="mTORC1-mediated signalling"/>
            <pathway-xref db="Reactome" id="R-HSA-9020702" name="Interleukin-1 signaling"/>
            <pathway-xref db="Reactome" id="R-DDI-674695" name="RNA Polymerase II Pre-transcription Events"/>
            <pathway-xref db="Reactome" id="R-SCE-8856828" name="Clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-HSA-3371497" name="HSP90 chaperone cycle for steroid hormone receptors (SHR)"/>
            <pathway-xref db="Reactome" id="R-SSC-174178" name="APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1"/>
            <pathway-xref db="Reactome" id="R-GGA-2559580" name="Oxidative Stress Induced Senescence"/>
            <pathway-xref db="Reactome" id="R-DRE-380259" name="Loss of Nlp from mitotic centrosomes"/>
            <pathway-xref db="Reactome" id="R-SSC-174048" name="APC/C:Cdc20 mediated degradation of Cyclin B"/>
            <pathway-xref db="Reactome" id="R-GGA-6791226" name="Major pathway of rRNA processing in the nucleolus and cytosol"/>
            <pathway-xref db="Reactome" id="R-DDI-6804757" name="Regulation of TP53 Degradation"/>
            <pathway-xref db="Reactome" id="R-CFA-392451" name="G beta:gamma signalling through PI3Kgamma"/>
            <pathway-xref db="Reactome" id="R-RNO-73863" name="RNA Polymerase I Transcription Termination"/>
            <pathway-xref db="Reactome" id="R-MMU-3214815" name="HDACs deacetylate histones"/>
            <pathway-xref db="Reactome" id="R-SPO-204005" name="COPII-mediated vesicle transport"/>
            <pathway-xref db="Reactome" id="R-SPO-76061" name="RNA Polymerase III Transcription Initiation From Type 1 Promoter"/>
            <pathway-xref db="Reactome" id="R-MMU-2559584" name="Formation of Senescence-Associated Heterochromatin Foci (SAHF)"/>
            <pathway-xref db="Reactome" id="R-MMU-8953750" name="Transcriptional Regulation by E2F6"/>
            <pathway-xref db="Reactome" id="R-XTR-212300" name="PRC2 methylates histones and DNA"/>
            <pathway-xref db="Reactome" id="R-MMU-9013420" name="RHOU GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-9013149" name="RAC1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-DRE-416476" name="G alpha (q) signalling events"/>
            <pathway-xref db="Reactome" id="R-DRE-5674135" name="MAP2K and MAPK activation"/>
            <pathway-xref db="Reactome" id="R-SSC-176409" name="APC/C:Cdc20 mediated degradation of mitotic proteins"/>
            <pathway-xref db="Reactome" id="R-DDI-6791226" name="Major pathway of rRNA processing in the nucleolus and cytosol"/>
            <pathway-xref db="Reactome" id="R-MMU-72165" name="mRNA Splicing - Minor Pathway"/>
            <pathway-xref db="Reactome" id="R-MMU-212300" name="PRC2 methylates histones and DNA"/>
            <pathway-xref db="Reactome" id="R-DME-380972" name="Energy dependent regulation of mTOR by LKB1-AMPK"/>
            <pathway-xref db="Reactome" id="R-MMU-418555" name="G alpha (s) signalling events"/>
            <pathway-xref db="Reactome" id="R-DDI-9013404" name="RAC2 GTPase cycle"/>
          </entry>
          <signature-library-release library="SUPERFAMILY" version="1.75"/>
        </signature>
        <model-ac>0049440</model-ac>
        <locations>
          <superfamilyhmmer3-location hmm-length="393" start="48" end="337">
            <location-fragments>
              <superfamilyhmmer3-location-fragment start="48" end="337" dc-status="CONTINUOUS"/>
            </location-fragments>
          </superfamilyhmmer3-location>
        </locations>
      </superfamilyhmmer3-match>
    </matches>
  </protein>
  <protein>
    <sequence md5="b5dfa5ba461ea81a9ff7e675179ee36e">MSAKVVCPQHPDANLIEDHRAGDMICSECGLVVGDRVIDVGSEWRTFSNEKGGEDRSRVGGPENNLLSGSDLSTMIGPSTGKASFDSDGNAMYTNRRTVSSSDRTLLNAIKVISSMCDRINLPRTITERANNLFKTVHEGRNLRGRSNEAIAAASLYIACRQEGVPRTFKEIVAVSTVSKKEIGRCFKLILKAHDDTNVDIITTGDFMDRFCGTLGLPRDVQRAATHIAKTAVDLDIVPGRSPISVAAAAIYMASQASSDPRSQKEIADIAGVADVTIRQSYKLMLPSARQLFPEKFKFHIPVEQLPQN</sequence>
    <xref id="TCALIF_00793-PA" name="TCALIF_00793-PA protein Name:&quot;Similar to TfIIB Transcription initiation factor IIB (Drosophila melanogaster)&quot; AED:0.02 eAED:0.02 QI:249|1|1|1|1|1|2|150|309"/>
    <matches>
      <fingerprints-match evalue="3.5E-69" graphscan="IIIIIIII">
        <signature ac="PR00685" desc="Transcription initiation factor IIB signature" name="TIFACTORIIB">
          <entry ac="IPR000812" desc="Transcription factor TFIIB" name="TFIIB" type="FAMILY">
            <go-xref category="BIOLOGICAL_PROCESS" db="GO" id="GO:0070897" name="transcription preinitiation complex assembly"/>
            <go-xref category="BIOLOGICAL_PROCESS" db="GO" id="GO:0006352" name="DNA-templated transcription, initiation"/>
            <pathway-xref db="Reactome" id="R-CEL-75953" name="RNA Polymerase II Transcription Initiation"/>
            <pathway-xref db="Reactome" id="R-DME-674695" name="RNA Polymerase II Pre-transcription Events"/>
            <pathway-xref db="Reactome" id="R-HSA-76061" name="RNA Polymerase III Transcription Initiation From Type 1 Promoter"/>
            <pathway-xref db="Reactome" id="R-MMU-73776" name="RNA Polymerase II Promoter Escape"/>
            <pathway-xref db="Reactome" id="R-SCE-76042" name="RNA Polymerase II Transcription Initiation And Promoter Clearance"/>
            <pathway-xref db="Reactome" id="R-SCE-73779" name="RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"/>
            <pathway-xref db="Reactome" id="R-MMU-76071" name="RNA Polymerase III Transcription Initiation From Type 3 Promoter"/>
            <pathway-xref db="Reactome" id="R-MMU-6807505" name="RNA polymerase II transcribes snRNA genes"/>
            <pathway-xref db="Reactome" id="R-SPO-73779" name="RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"/>
            <pathway-xref db="Reactome" id="R-HSA-167161" name="HIV Transcription Initiation"/>
            <pathway-xref db="Reactome" id="R-RNO-76071" name="RNA Polymerase III Transcription Initiation From Type 3 Promoter"/>
            <pathway-xref db="Reactome" id="R-RNO-73779" name="RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"/>
            <pathway-xref db="Reactome" id="R-MMU-73779" name="RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"/>
            <pathway-xref db="Reactome" id="R-SCE-674695" name="RNA Polymerase II Pre-transcription Events"/>
            <pathway-xref db="Reactome" id="R-MMU-76042" name="RNA Polymerase II Transcription Initiation And Promoter Clearance"/>
            <pathway-xref db="Reactome" id="R-MMU-76066" name="RNA Polymerase III Transcription Initiation From Type 2 Promoter"/>
            <pathway-xref db="Reactome" id="R-RNO-76042" name="RNA Polymerase II Transcription Initiation And Promoter Clearance"/>
            <pathway-xref db="Reactome" id="R-DME-73776" name="RNA Polymerase II Promoter Escape"/>
            <pathway-xref db="Reactome" id="R-RNO-674695" name="RNA Polymerase II Pre-transcription Events"/>
            <pathway-xref db="Reactome" id="R-HSA-76066" name="RNA Polymerase III Transcription Initiation From Type 2 Promoter"/>
            <pathway-xref db="Reactome" id="R-DDI-75953" name="RNA Polymerase II Transcription Initiation"/>
            <pathway-xref db="Reactome" id="R-SPO-76042" name="RNA Polymerase II Transcription Initiation And Promoter Clearance"/>
            <pathway-xref db="Reactome" id="R-SCE-6807505" name="RNA polymerase II transcribes snRNA genes"/>
            <pathway-xref db="Reactome" id="R-SCE-76066" name="RNA Polymerase III Transcription Initiation From Type 2 Promoter"/>
            <pathway-xref db="Reactome" id="R-DDI-76042" name="RNA Polymerase II Transcription Initiation And Promoter Clearance"/>
            <pathway-xref db="Reactome" id="R-HSA-75953" name="RNA Polymerase II Transcription Initiation"/>
            <pathway-xref db="Reactome" id="R-DME-73779" name="RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"/>
            <pathway-xref db="Reactome" id="R-SPO-6807505" name="RNA polymerase II transcribes snRNA genes"/>
            <pathway-xref db="Reactome" id="R-SCE-75953" name="RNA Polymerase II Transcription Initiation"/>
            <pathway-xref db="Reactome" id="R-MMU-76061" name="RNA Polymerase III Transcription Initiation From Type 1 Promoter"/>
            <pathway-xref db="Reactome" id="R-HSA-73776" name="RNA Polymerase II Promoter Escape"/>
            <pathway-xref db="Reactome" id="R-MMU-75953" name="RNA Polymerase II Transcription Initiation"/>
            <pathway-xref db="Reactome" id="R-SCE-76061" name="RNA Polymerase III Transcription Initiation From Type 1 Promoter"/>
            <pathway-xref db="Reactome" id="R-CEL-73776" name="RNA Polymerase II Promoter Escape"/>
            <pathway-xref db="Reactome" id="R-HSA-167162" name="RNA Polymerase II HIV Promoter Escape"/>
            <pathway-xref db="Reactome" id="R-CEL-73779" name="RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"/>
            <pathway-xref db="Reactome" id="R-SPO-73776" name="RNA Polymerase II Promoter Escape"/>
            <pathway-xref db="Reactome" id="R-HSA-674695" name="RNA Polymerase II Pre-transcription Events"/>
            <pathway-xref db="Reactome" id="R-SPO-76066" name="RNA Polymerase III Transcription Initiation From Type 2 Promoter"/>
            <pathway-xref db="Reactome" id="R-HSA-76042" name="RNA Polymerase II Transcription Initiation And Promoter Clearance"/>
            <pathway-xref db="Reactome" id="R-CEL-6807505" name="RNA polymerase II transcribes snRNA genes"/>
            <pathway-xref db="Reactome" id="R-DME-6807505" name="RNA polymerase II transcribes snRNA genes"/>
            <pathway-xref db="Reactome" id="R-RNO-73776" name="RNA Polymerase II Promoter Escape"/>
            <pathway-xref db="Reactome" id="R-SPO-674695" name="RNA Polymerase II Pre-transcription Events"/>
            <pathway-xref db="Reactome" id="R-DDI-674695" name="RNA Polymerase II Pre-transcription Events"/>
            <pathway-xref db="Reactome" id="R-HSA-167172" name="Transcription of the HIV genome"/>
            <pathway-xref db="Reactome" id="R-CEL-76042" name="RNA Polymerase II Transcription Initiation And Promoter Clearance"/>
            <pathway-xref db="Reactome" id="R-SPO-75953" name="RNA Polymerase II Transcription Initiation"/>
            <pathway-xref db="Reactome" id="R-DME-76042" name="RNA Polymerase II Transcription Initiation And Promoter Clearance"/>
            <pathway-xref db="Reactome" id="R-HSA-749476" name="RNA Polymerase III Abortive And Retractive Initiation"/>
            <pathway-xref db="Reactome" id="R-DRE-76071" name="RNA Polymerase III Transcription Initiation From Type 3 Promoter"/>
            <pathway-xref db="Reactome" id="R-SPO-76061" name="RNA Polymerase III Transcription Initiation From Type 1 Promoter"/>
            <pathway-xref db="Reactome" id="R-DME-75953" name="RNA Polymerase II Transcription Initiation"/>
            <pathway-xref db="Reactome" id="R-RNO-6807505" name="RNA polymerase II transcribes snRNA genes"/>
            <pathway-xref db="Reactome" id="R-HSA-6807505" name="RNA polymerase II transcribes snRNA genes"/>
            <pathway-xref db="Reactome" id="R-RNO-75953" name="RNA Polymerase II Transcription Initiation"/>
            <pathway-xref db="Reactome" id="R-HSA-73779" name="RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"/>
            <pathway-xref db="Reactome" id="R-HSA-76071" name="RNA Polymerase III Transcription Initiation From Type 3 Promoter"/>
            <pathway-xref db="Reactome" id="R-CEL-674695" name="RNA Polymerase II Pre-transcription Events"/>
            <pathway-xref db="Reactome" id="R-SCE-73776" name="RNA Polymerase II Promoter Escape"/>
            <pathway-xref db="Reactome" id="R-DDI-6807505" name="RNA polymerase II transcribes snRNA genes"/>
            <pathway-xref db="Reactome" id="R-MMU-674695" name="RNA Polymerase II Pre-transcription Events"/>
            <pathway-xref db="Reactome" id="R-DDI-73776" name="RNA Polymerase II Promoter Escape"/>
            <pathway-xref db="Reactome" id="R-DDI-73779" name="RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"/>
          </entry>
          <signature-library-release library="PRINTS" version="42.0"/>
        </signature>
        <model-ac>PR00685</model-ac>
        <locations>
          <fingerprints-location motifNumber="1" pvalue="4.46E-12" score="57.78" start="19" end="39">
            <location-fragments>
              <fingerprints-location-fragment start="19" end="39" dc-status="CONTINUOUS"/>
            </location-fragments>
          </fingerprints-location>
          <fingerprints-location motifNumber="2" pvalue="1.12E-5" score="55.71" start="41" end="54">
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            <pathway-xref db="Reactome" id="R-CEL-73776" name="RNA Polymerase II Promoter Escape"/>
            <pathway-xref db="Reactome" id="R-HSA-167162" name="RNA Polymerase II HIV Promoter Escape"/>
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            <pathway-xref db="Reactome" id="R-DDI-674695" name="RNA Polymerase II Pre-transcription Events"/>
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            <pathway-xref db="Reactome" id="R-CEL-76042" name="RNA Polymerase II Transcription Initiation And Promoter Clearance"/>
            <pathway-xref db="Reactome" id="R-SPO-75953" name="RNA Polymerase II Transcription Initiation"/>
            <pathway-xref db="Reactome" id="R-DME-76042" name="RNA Polymerase II Transcription Initiation And Promoter Clearance"/>
            <pathway-xref db="Reactome" id="R-HSA-749476" name="RNA Polymerase III Abortive And Retractive Initiation"/>
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            <pathway-xref db="Reactome" id="R-HSA-6807505" name="RNA polymerase II transcribes snRNA genes"/>
            <pathway-xref db="Reactome" id="R-RNO-75953" name="RNA Polymerase II Transcription Initiation"/>
            <pathway-xref db="Reactome" id="R-HSA-73779" name="RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"/>
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            <pathway-xref db="Reactome" id="R-SCE-73776" name="RNA Polymerase II Promoter Escape"/>
            <pathway-xref db="Reactome" id="R-DDI-6807505" name="RNA polymerase II transcribes snRNA genes"/>
            <pathway-xref db="Reactome" id="R-MMU-674695" name="RNA Polymerase II Pre-transcription Events"/>
            <pathway-xref db="Reactome" id="R-DDI-73776" name="RNA Polymerase II Promoter Escape"/>
            <pathway-xref db="Reactome" id="R-DDI-73779" name="RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"/>
          </entry>
          <signature-library-release library="PFAM" version="34.0"/>
        </signature>
        <model-ac>PF08271</model-ac>
        <locations>
          <hmmer3-location env-end="47" env-start="5" post-processed="true" score="50.9" evalue="7.8E-14" hmm-start="2" hmm-end="43" hmm-length="43" hmm-bounds="C_TERMINAL_COMPLETE" start="6" end="47">
            <location-fragments>
              <hmmer3-location-fragment start="6" end="47" dc-status="CONTINUOUS"/>
            </location-fragments>
          </hmmer3-location>
        </locations>
      </hmmer3-match>
      <hmmer3-match evalue="3.5E-62" score="209.4">
        <signature ac="G3DSA:1.10.472.10" name="">
          <signature-library-release library="GENE3D" version="4.3.0"/>
        </signature>
        <model-ac>3k7aM01</model-ac>
        <locations>
          <hmmer3-location env-end="196" env-start="90" post-processed="true" score="130.9" evalue="8.0E-38" hmm-start="13" hmm-end="111" hmm-length="116" hmm-bounds="COMPLETE" start="90" end="196">
            <location-fragments>
              <hmmer3-location-fragment start="90" end="196" dc-status="CONTINUOUS"/>
            </location-fragments>
          </hmmer3-location>
        </locations>
      </hmmer3-match>
      <panther-match evalue="1.2E-79" familyName="TRANSCRIPTION INITIATION FACTOR IIB" score="279.9">
        <signature ac="PTHR11618:SF13" name="TRANSCRIPTION INITIATION FACTOR IIB">
          <signature-library-release library="PANTHER" version="15.0"/>
        </signature>
        <model-ac>PTHR11618:SF13</model-ac>
        <locations>
          <panther-location env-start="3" env-end="307" hmm-start="3" hmm-end="278" hmm-length="307" hmm-bounds="INCOMPLETE" start="5" end="291">
            <location-fragments>
              <panther-location-fragment start="5" end="291" dc-status="CONTINUOUS"/>
            </location-fragments>
          </panther-location>
        </locations>
      </panther-match>
      <panther-match evalue="1.2E-79" familyName="TRANSCRIPTION INITIATION FACTOR IIB" score="279.9">
        <signature ac="PTHR11618" name="TRANSCRIPTION INITIATION FACTOR IIB-RELATED">
          <entry ac="IPR000812" desc="Transcription factor TFIIB" name="TFIIB" type="FAMILY">
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            <go-xref category="BIOLOGICAL_PROCESS" db="GO" id="GO:0006352" name="DNA-templated transcription, initiation"/>
            <pathway-xref db="Reactome" id="R-CEL-75953" name="RNA Polymerase II Transcription Initiation"/>
            <pathway-xref db="Reactome" id="R-DME-674695" name="RNA Polymerase II Pre-transcription Events"/>
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            <pathway-xref db="Reactome" id="R-MMU-73776" name="RNA Polymerase II Promoter Escape"/>
            <pathway-xref db="Reactome" id="R-SCE-76042" name="RNA Polymerase II Transcription Initiation And Promoter Clearance"/>
            <pathway-xref db="Reactome" id="R-SCE-73779" name="RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"/>
            <pathway-xref db="Reactome" id="R-MMU-76071" name="RNA Polymerase III Transcription Initiation From Type 3 Promoter"/>
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            <pathway-xref db="Reactome" id="R-MMU-73779" name="RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"/>
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            <pathway-xref db="Reactome" id="R-MMU-76066" name="RNA Polymerase III Transcription Initiation From Type 2 Promoter"/>
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          </entry>
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        </signature>
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            <pathway-xref db="Reactome" id="R-MMU-75953" name="RNA Polymerase II Transcription Initiation"/>
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          </entry>
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        <model-ac>PS00782</model-ac>
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      </patternscan-match>
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            <pathway-xref db="Reactome" id="R-DME-75953" name="RNA Polymerase II Transcription Initiation"/>
            <pathway-xref db="Reactome" id="R-RNO-6807505" name="RNA polymerase II transcribes snRNA genes"/>
            <pathway-xref db="Reactome" id="R-HSA-6807505" name="RNA polymerase II transcribes snRNA genes"/>
            <pathway-xref db="Reactome" id="R-RNO-75953" name="RNA Polymerase II Transcription Initiation"/>
            <pathway-xref db="Reactome" id="R-HSA-73779" name="RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"/>
            <pathway-xref db="Reactome" id="R-CEL-674695" name="RNA Polymerase II Pre-transcription Events"/>
            <pathway-xref db="Reactome" id="R-SCE-73776" name="RNA Polymerase II Promoter Escape"/>
            <pathway-xref db="Reactome" id="R-DDI-73776" name="RNA Polymerase II Promoter Escape"/>
            <pathway-xref db="Reactome" id="R-DDI-73779" name="RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"/>
            <pathway-xref db="Reactome" id="R-CEL-75953" name="RNA Polymerase II Transcription Initiation"/>
            <pathway-xref db="Reactome" id="R-MMU-73776" name="RNA Polymerase II Promoter Escape"/>
            <pathway-xref db="Reactome" id="R-SPO-73779" name="RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"/>
            <pathway-xref db="Reactome" id="R-HSA-167161" name="HIV Transcription Initiation"/>
            <pathway-xref db="Reactome" id="R-MMU-73779" name="RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"/>
            <pathway-xref db="Reactome" id="R-SCE-674695" name="RNA Polymerase II Pre-transcription Events"/>
            <pathway-xref db="Reactome" id="R-MMU-76042" name="RNA Polymerase II Transcription Initiation And Promoter Clearance"/>
            <pathway-xref db="Reactome" id="R-RNO-674695" name="RNA Polymerase II Pre-transcription Events"/>
            <pathway-xref db="Reactome" id="R-SPO-76042" name="RNA Polymerase II Transcription Initiation And Promoter Clearance"/>
            <pathway-xref db="Reactome" id="R-SCE-76066" name="RNA Polymerase III Transcription Initiation From Type 2 Promoter"/>
            <pathway-xref db="Reactome" id="R-HSA-75953" name="RNA Polymerase II Transcription Initiation"/>
            <pathway-xref db="Reactome" id="R-MMU-75953" name="RNA Polymerase II Transcription Initiation"/>
            <pathway-xref db="Reactome" id="R-CEL-73776" name="RNA Polymerase II Promoter Escape"/>
            <pathway-xref db="Reactome" id="R-HSA-167162" name="RNA Polymerase II HIV Promoter Escape"/>
            <pathway-xref db="Reactome" id="R-CEL-73779" name="RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"/>
            <pathway-xref db="Reactome" id="R-SPO-73776" name="RNA Polymerase II Promoter Escape"/>
            <pathway-xref db="Reactome" id="R-HSA-674695" name="RNA Polymerase II Pre-transcription Events"/>
            <pathway-xref db="Reactome" id="R-DDI-674695" name="RNA Polymerase II Pre-transcription Events"/>
            <pathway-xref db="Reactome" id="R-HSA-167172" name="Transcription of the HIV genome"/>
            <pathway-xref db="Reactome" id="R-CEL-76042" name="RNA Polymerase II Transcription Initiation And Promoter Clearance"/>
            <pathway-xref db="Reactome" id="R-SPO-75953" name="RNA Polymerase II Transcription Initiation"/>
            <pathway-xref db="Reactome" id="R-DME-76042" name="RNA Polymerase II Transcription Initiation And Promoter Clearance"/>
            <pathway-xref db="Reactome" id="R-DDI-6807505" name="RNA polymerase II transcribes snRNA genes"/>
            <pathway-xref db="Reactome" id="R-MMU-674695" name="RNA Polymerase II Pre-transcription Events"/>
          </entry>
          <signature-library-release library="PROSITE_PATTERNS" version="2021_01"/>
        </signature>
        <model-ac>PS00782</model-ac>
        <locations>
          <patternscan-location level="STRONG" start="240" end="255">
            <location-fragments>
              <patternscan-location-fragment start="240" end="255" dc-status="CONTINUOUS"/>
            </location-fragments>
            <alignment>GRspiSVAAAAIYMAS</alignment>
          </patternscan-location>
        </locations>
      </patternscan-match>
      <profilescan-match>
        <signature ac="PS51134" desc="Zinc finger TFIIB-type profile." name="ZF_TFIIB">
          <entry ac="IPR013137" desc="Zinc finger, TFIIB-type" name="Znf_TFIIB" type="DOMAIN">
            <pathway-xref db="Reactome" id="R-CEL-75953" name="RNA Polymerase II Transcription Initiation"/>
            <pathway-xref db="Reactome" id="R-DME-674695" name="RNA Polymerase II Pre-transcription Events"/>
            <pathway-xref db="Reactome" id="R-HSA-76061" name="RNA Polymerase III Transcription Initiation From Type 1 Promoter"/>
            <pathway-xref db="Reactome" id="R-MMU-73776" name="RNA Polymerase II Promoter Escape"/>
            <pathway-xref db="Reactome" id="R-SCE-76042" name="RNA Polymerase II Transcription Initiation And Promoter Clearance"/>
            <pathway-xref db="Reactome" id="R-SCE-73779" name="RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"/>
            <pathway-xref db="Reactome" id="R-MMU-76071" name="RNA Polymerase III Transcription Initiation From Type 3 Promoter"/>
            <pathway-xref db="Reactome" id="R-MMU-6807505" name="RNA polymerase II transcribes snRNA genes"/>
            <pathway-xref db="Reactome" id="R-SPO-73779" name="RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"/>
            <pathway-xref db="Reactome" id="R-HSA-167161" name="HIV Transcription Initiation"/>
            <pathway-xref db="Reactome" id="R-RNO-76071" name="RNA Polymerase III Transcription Initiation From Type 3 Promoter"/>
            <pathway-xref db="Reactome" id="R-RNO-73779" name="RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"/>
            <pathway-xref db="Reactome" id="R-MMU-73779" name="RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"/>
            <pathway-xref db="Reactome" id="R-SCE-674695" name="RNA Polymerase II Pre-transcription Events"/>
            <pathway-xref db="Reactome" id="R-MMU-76042" name="RNA Polymerase II Transcription Initiation And Promoter Clearance"/>
            <pathway-xref db="Reactome" id="R-MMU-76066" name="RNA Polymerase III Transcription Initiation From Type 2 Promoter"/>
            <pathway-xref db="Reactome" id="R-RNO-76042" name="RNA Polymerase II Transcription Initiation And Promoter Clearance"/>
            <pathway-xref db="Reactome" id="R-DME-73776" name="RNA Polymerase II Promoter Escape"/>
            <pathway-xref db="Reactome" id="R-RNO-674695" name="RNA Polymerase II Pre-transcription Events"/>
            <pathway-xref db="Reactome" id="R-HSA-76066" name="RNA Polymerase III Transcription Initiation From Type 2 Promoter"/>
            <pathway-xref db="Reactome" id="R-DDI-75953" name="RNA Polymerase II Transcription Initiation"/>
            <pathway-xref db="Reactome" id="R-SPO-76042" name="RNA Polymerase II Transcription Initiation And Promoter Clearance"/>
            <pathway-xref db="Reactome" id="R-SCE-6807505" name="RNA polymerase II transcribes snRNA genes"/>
            <pathway-xref db="Reactome" id="R-SCE-76066" name="RNA Polymerase III Transcription Initiation From Type 2 Promoter"/>
            <pathway-xref db="Reactome" id="R-DDI-76042" name="RNA Polymerase II Transcription Initiation And Promoter Clearance"/>
            <pathway-xref db="Reactome" id="R-HSA-75953" name="RNA Polymerase II Transcription Initiation"/>
            <pathway-xref db="Reactome" id="R-DME-73779" name="RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"/>
            <pathway-xref db="Reactome" id="R-SPO-6807505" name="RNA polymerase II transcribes snRNA genes"/>
            <pathway-xref db="Reactome" id="R-SCE-75953" name="RNA Polymerase II Transcription Initiation"/>
            <pathway-xref db="Reactome" id="R-MMU-76061" name="RNA Polymerase III Transcription Initiation From Type 1 Promoter"/>
            <pathway-xref db="Reactome" id="R-HSA-73776" name="RNA Polymerase II Promoter Escape"/>
            <pathway-xref db="Reactome" id="R-MMU-75953" name="RNA Polymerase II Transcription Initiation"/>
            <pathway-xref db="Reactome" id="R-SCE-76061" name="RNA Polymerase III Transcription Initiation From Type 1 Promoter"/>
            <pathway-xref db="Reactome" id="R-CEL-73776" name="RNA Polymerase II Promoter Escape"/>
            <pathway-xref db="Reactome" id="R-HSA-167162" name="RNA Polymerase II HIV Promoter Escape"/>
            <pathway-xref db="Reactome" id="R-CEL-73779" name="RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"/>
            <pathway-xref db="Reactome" id="R-SPO-73776" name="RNA Polymerase II Promoter Escape"/>
            <pathway-xref db="Reactome" id="R-HSA-674695" name="RNA Polymerase II Pre-transcription Events"/>
            <pathway-xref db="Reactome" id="R-SPO-76066" name="RNA Polymerase III Transcription Initiation From Type 2 Promoter"/>
            <pathway-xref db="Reactome" id="R-HSA-76042" name="RNA Polymerase II Transcription Initiation And Promoter Clearance"/>
            <pathway-xref db="Reactome" id="R-CEL-6807505" name="RNA polymerase II transcribes snRNA genes"/>
            <pathway-xref db="Reactome" id="R-DME-6807505" name="RNA polymerase II transcribes snRNA genes"/>
            <pathway-xref db="Reactome" id="R-RNO-73776" name="RNA Polymerase II Promoter Escape"/>
            <pathway-xref db="Reactome" id="R-SPO-674695" name="RNA Polymerase II Pre-transcription Events"/>
            <pathway-xref db="Reactome" id="R-DDI-674695" name="RNA Polymerase II Pre-transcription Events"/>
            <pathway-xref db="Reactome" id="R-HSA-167172" name="Transcription of the HIV genome"/>
            <pathway-xref db="Reactome" id="R-CEL-76042" name="RNA Polymerase II Transcription Initiation And Promoter Clearance"/>
            <pathway-xref db="Reactome" id="R-SPO-75953" name="RNA Polymerase II Transcription Initiation"/>
            <pathway-xref db="Reactome" id="R-DME-76042" name="RNA Polymerase II Transcription Initiation And Promoter Clearance"/>
            <pathway-xref db="Reactome" id="R-HSA-749476" name="RNA Polymerase III Abortive And Retractive Initiation"/>
            <pathway-xref db="Reactome" id="R-DRE-76071" name="RNA Polymerase III Transcription Initiation From Type 3 Promoter"/>
            <pathway-xref db="Reactome" id="R-SPO-76061" name="RNA Polymerase III Transcription Initiation From Type 1 Promoter"/>
            <pathway-xref db="Reactome" id="R-DME-75953" name="RNA Polymerase II Transcription Initiation"/>
            <pathway-xref db="Reactome" id="R-RNO-6807505" name="RNA polymerase II transcribes snRNA genes"/>
            <pathway-xref db="Reactome" id="R-HSA-6807505" name="RNA polymerase II transcribes snRNA genes"/>
            <pathway-xref db="Reactome" id="R-RNO-75953" name="RNA Polymerase II Transcription Initiation"/>
            <pathway-xref db="Reactome" id="R-HSA-73779" name="RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"/>
            <pathway-xref db="Reactome" id="R-HSA-76071" name="RNA Polymerase III Transcription Initiation From Type 3 Promoter"/>
            <pathway-xref db="Reactome" id="R-CEL-674695" name="RNA Polymerase II Pre-transcription Events"/>
            <pathway-xref db="Reactome" id="R-SCE-73776" name="RNA Polymerase II Promoter Escape"/>
            <pathway-xref db="Reactome" id="R-DDI-6807505" name="RNA polymerase II transcribes snRNA genes"/>
            <pathway-xref db="Reactome" id="R-MMU-674695" name="RNA Polymerase II Pre-transcription Events"/>
            <pathway-xref db="Reactome" id="R-DDI-73776" name="RNA Polymerase II Promoter Escape"/>
            <pathway-xref db="Reactome" id="R-DDI-73779" name="RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"/>
          </entry>
          <signature-library-release library="PROSITE_PROFILES" version="2021_01"/>
        </signature>
        <model-ac>PS51134</model-ac>
        <locations>
          <profilescan-location score="9.706526" start="3" end="34">
            <location-fragments>
              <profilescan-location-fragment start="3" end="34" dc-status="CONTINUOUS"/>
            </location-fragments>
            <alignment>AKVVCPQHPDANLIEDHRAGDMICSECGLVVG</alignment>
          </profilescan-location>
        </locations>
      </profilescan-match>
      <rpsblast-match>
        <signature ac="cd00043" desc="CYCLIN" name="CYCLIN">
          <entry ac="IPR013763" desc="Cyclin-like" name="Cyclin-like" type="DOMAIN">
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            <pathway-xref db="Reactome" id="R-CEL-6804116" name="TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest"/>
            <pathway-xref db="Reactome" id="R-DME-674695" name="RNA Polymerase II Pre-transcription Events"/>
            <pathway-xref db="Reactome" id="R-HSA-72086" name="mRNA Capping"/>
            <pathway-xref db="Reactome" id="R-RNO-3301854" name="Nuclear Pore Complex (NPC) Disassembly"/>
            <pathway-xref db="Reactome" id="R-HSA-113418" name="Formation of the Early Elongation Complex"/>
            <pathway-xref db="Reactome" id="R-HSA-2565942" name="Regulation of PLK1 Activity at G2/M Transition"/>
            <pathway-xref db="Reactome" id="R-DME-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-MMU-2565942" name="Regulation of PLK1 Activity at G2/M Transition"/>
            <pathway-xref db="Reactome" id="R-RNO-73779" name="RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"/>
            <pathway-xref db="Reactome" id="R-HSA-113501" name="Inhibition of replication initiation of damaged DNA by RB1/E2F1"/>
            <pathway-xref db="Reactome" id="R-HSA-2559586" name="DNA Damage/Telomere Stress Induced Senescence"/>
            <pathway-xref db="Reactome" id="R-RNO-6804757" name="Regulation of TP53 Degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-2559586" name="DNA Damage/Telomere Stress Induced Senescence"/>
            <pathway-xref db="Reactome" id="R-MMU-171319" name="Telomere Extension By Telomerase"/>
            <pathway-xref db="Reactome" id="R-CEL-9018519" name="Estrogen-dependent gene expression"/>
            <pathway-xref db="Reactome" id="R-DME-68911" name="G2 Phase"/>
            <pathway-xref db="Reactome" id="R-RNO-6796648" name="TP53 Regulates Transcription of DNA Repair Genes"/>
            <pathway-xref db="Reactome" id="R-SPO-75955" name="RNA Polymerase II Transcription Elongation"/>
            <pathway-xref db="Reactome" id="R-SCE-113418" name="Formation of the Early Elongation Complex"/>
            <pathway-xref db="Reactome" id="R-SCE-76061" name="RNA Polymerase III Transcription Initiation From Type 1 Promoter"/>
            <pathway-xref db="Reactome" id="R-SCE-9018519" name="Estrogen-dependent gene expression"/>
            <pathway-xref db="Reactome" id="R-DME-69656" name="Cyclin A:Cdk2-associated events at S phase entry"/>
            <pathway-xref db="Reactome" id="R-GGA-2980767" name="Activation of NIMA Kinases NEK9, NEK6, NEK7"/>
            <pathway-xref db="Reactome" id="R-MMU-8934593" name="Regulation of RUNX1 Expression and Activity"/>
            <pathway-xref db="Reactome" id="R-HSA-8940973" name="RUNX2 regulates osteoblast differentiation"/>
            <pathway-xref db="Reactome" id="R-MMU-9706019" name="RHOBTB3 ATPase cycle"/>
            <pathway-xref db="Reactome" id="R-DRE-187577" name="SCF(Skp2)-mediated degradation of p27/p21"/>
            <pathway-xref db="Reactome" id="R-HSA-390471" name="Association of TriC/CCT with target proteins during biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SCE-73776" name="RNA Polymerase II Promoter Escape"/>
            <pathway-xref db="Reactome" id="R-DDI-72086" name="mRNA Capping"/>
            <pathway-xref db="Reactome" id="R-DME-176412" name="Phosphorylation of the APC/C"/>
            <pathway-xref db="Reactome" id="R-HSA-171319" name="Telomere Extension By Telomerase"/>
            <pathway-xref db="Reactome" id="R-DME-112382" name="Formation of RNA Pol II elongation complex"/>
            <pathway-xref db="Reactome" id="R-SPO-69017" name="CDK-mediated phosphorylation and removal of Cdc6"/>
            <pathway-xref db="Reactome" id="R-DME-2995383" name="Initiation of Nuclear Envelope (NE) Reformation"/>
            <pathway-xref db="Reactome" id="R-HSA-9617828" name="FOXO-mediated transcription of cell cycle genes"/>
            <pathway-xref db="Reactome" id="R-MMU-68911" name="G2 Phase"/>
            <pathway-xref db="Reactome" id="R-CEL-69202" name="Cyclin E associated events during G1/S transition"/>
            <pathway-xref db="Reactome" id="R-DRE-69202" name="Cyclin E associated events during G1/S transition"/>
            <pathway-xref db="Reactome" id="R-CEL-68949" name="Orc1 removal from chromatin"/>
            <pathway-xref db="Reactome" id="R-HSA-2465910" name="MASTL Facilitates Mitotic Progression"/>
            <pathway-xref db="Reactome" id="R-DME-176417" name="Phosphorylation of Emi1"/>
            <pathway-xref db="Reactome" id="R-DRE-6804116" name="TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest"/>
            <pathway-xref db="Reactome" id="R-DDI-75955" name="RNA Polymerase II Transcription Elongation"/>
            <pathway-xref db="Reactome" id="R-HSA-68875" name="Mitotic Prophase"/>
            <pathway-xref db="Reactome" id="R-SCE-76066" name="RNA Polymerase III Transcription Initiation From Type 2 Promoter"/>
            <pathway-xref db="Reactome" id="R-DDI-6782135" name="Dual incision in TC-NER"/>
            <pathway-xref db="Reactome" id="R-HSA-5696395" name="Formation of Incision Complex in GG-NER"/>
            <pathway-xref db="Reactome" id="R-MMU-8951664" name="Neddylation"/>
            <pathway-xref db="Reactome" id="R-RNO-68875" name="Mitotic Prophase"/>
            <pathway-xref db="Reactome" id="R-HSA-2299718" name="Condensation of Prophase Chromosomes"/>
            <pathway-xref db="Reactome" id="R-HSA-174048" name="APC/C:Cdc20 mediated degradation of Cyclin B"/>
            <pathway-xref db="Reactome" id="R-MMU-2299718" name="Condensation of Prophase Chromosomes"/>
            <pathway-xref db="Reactome" id="R-SCE-69656" name="Cyclin A:Cdk2-associated events at S phase entry"/>
            <pathway-xref db="Reactome" id="R-MMU-2173796" name="SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription"/>
            <pathway-xref db="Reactome" id="R-HSA-176408" name="Regulation of APC/C activators between G1/S and early anaphase"/>
            <pathway-xref db="Reactome" id="R-CEL-73779" name="RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"/>
            <pathway-xref db="Reactome" id="R-HSA-1362300" name="Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1"/>
            <pathway-xref db="Reactome" id="R-DRE-75955" name="RNA Polymerase II Transcription Elongation"/>
            <pathway-xref db="Reactome" id="R-DME-4419969" name="Depolymerisation of the Nuclear Lamina"/>
            <pathway-xref db="Reactome" id="R-RNO-9707616" name="Heme signaling"/>
            <pathway-xref db="Reactome" id="R-DDI-69202" name="Cyclin E associated events during G1/S transition"/>
            <pathway-xref db="Reactome" id="R-MMU-69656" name="Cyclin A:Cdk2-associated events at S phase entry"/>
            <pathway-xref db="Reactome" id="R-DME-2559582" name="Senescence-Associated Secretory Phenotype (SASP)"/>
            <pathway-xref db="Reactome" id="R-HSA-167243" name="Tat-mediated HIV elongation arrest and recovery"/>
            <pathway-xref db="Reactome" id="R-HSA-1362277" name="Transcription of E2F targets under negative control by DREAM complex"/>
            <pathway-xref db="Reactome" id="R-MMU-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-6781827" name="Transcription-Coupled Nucleotide Excision Repair (TC-NER)"/>
            <pathway-xref db="Reactome" id="R-MMU-113418" name="Formation of the Early Elongation Complex"/>
            <pathway-xref db="Reactome" id="R-MMU-69231" name="Cyclin D associated events in G1"/>
            <pathway-xref db="Reactome" id="R-SPO-5687128" name="MAPK6/MAPK4 signaling"/>
            <pathway-xref db="Reactome" id="R-DDI-6782210" name="Gap-filling DNA repair synthesis and ligation in TC-NER"/>
            <pathway-xref db="Reactome" id="R-GGA-3301854" name="Nuclear Pore Complex (NPC) Disassembly"/>
            <pathway-xref db="Reactome" id="R-RNO-1538133" name="G0 and Early G1"/>
            <pathway-xref db="Reactome" id="R-MMU-6807505" name="RNA polymerase II transcribes snRNA genes"/>
            <pathway-xref db="Reactome" id="R-DDI-2559582" name="Senescence-Associated Secretory Phenotype (SASP)"/>
            <pathway-xref db="Reactome" id="R-SPO-72086" name="mRNA Capping"/>
            <pathway-xref db="Reactome" id="R-CEL-6796648" name="TP53 Regulates Transcription of DNA Repair Genes"/>
            <pathway-xref db="Reactome" id="R-HSA-75955" name="RNA Polymerase II Transcription Elongation"/>
            <pathway-xref db="Reactome" id="R-GGA-69231" name="Cyclin D associated events in G1"/>
            <pathway-xref db="Reactome" id="R-RNO-187577" name="SCF(Skp2)-mediated degradation of p27/p21"/>
            <pathway-xref db="Reactome" id="R-MMU-212436" name="Generic Transcription Pathway"/>
            <pathway-xref db="Reactome" id="R-GGA-2565942" name="Regulation of PLK1 Activity at G2/M Transition"/>
            <pathway-xref db="Reactome" id="R-RNO-8866423" name="VLDL assembly"/>
            <pathway-xref db="Reactome" id="R-MMU-76061" name="RNA Polymerase III Transcription Initiation From Type 1 Promoter"/>
            <pathway-xref db="Reactome" id="R-MMU-5696395" name="Formation of Incision Complex in GG-NER"/>
            <pathway-xref db="Reactome" id="R-MMU-6781823" name="Formation of TC-NER Pre-Incision Complex"/>
            <pathway-xref db="Reactome" id="R-DRE-69017" name="CDK-mediated phosphorylation and removal of Cdc6"/>
            <pathway-xref db="Reactome" id="R-RNO-8964026" name="Chylomicron clearance"/>
            <pathway-xref db="Reactome" id="R-HSA-1538133" name="G0 and Early G1"/>
            <pathway-xref db="Reactome" id="R-DRE-6796648" name="TP53 Regulates Transcription of DNA Repair Genes"/>
            <pathway-xref db="Reactome" id="R-MMU-73762" name="RNA Polymerase I Transcription Initiation"/>
            <pathway-xref db="Reactome" id="R-RNO-68949" name="Orc1 removal from chromatin"/>
            <pathway-xref db="Reactome" id="R-HSA-6781823" name="Formation of TC-NER Pre-Incision Complex"/>
            <pathway-xref db="Reactome" id="R-MMU-69017" name="CDK-mediated phosphorylation and removal of Cdc6"/>
            <pathway-xref db="Reactome" id="R-DDI-68911" name="G2 Phase"/>
            <pathway-xref db="Reactome" id="R-SCE-69017" name="CDK-mediated phosphorylation and removal of Cdc6"/>
            <pathway-xref db="Reactome" id="R-CEL-112382" name="Formation of RNA Pol II elongation complex"/>
            <pathway-xref db="Reactome" id="R-RNO-6807505" name="RNA polymerase II transcribes snRNA genes"/>
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            <pathway-xref db="Reactome" id="R-MMU-9018519" name="Estrogen-dependent gene expression"/>
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            <pathway-xref db="Reactome" id="R-RNO-381426" name="Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)"/>
            <pathway-xref db="Reactome" id="R-MMU-176417" name="Phosphorylation of Emi1"/>
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            <pathway-xref db="Reactome" id="R-DME-68949" name="Orc1 removal from chromatin"/>
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            <pathway-xref db="Reactome" id="R-CEL-176408" name="Regulation of APC/C activators between G1/S and early anaphase"/>
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            <pathway-xref db="Reactome" id="R-DME-187577" name="SCF(Skp2)-mediated degradation of p27/p21"/>
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            <pathway-xref db="Reactome" id="R-RNO-2173796" name="SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription"/>
            <pathway-xref db="Reactome" id="R-GGA-8934593" name="Regulation of RUNX1 Expression and Activity"/>
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            <pathway-xref db="Reactome" id="R-HSA-167238" name="Pausing and recovery of Tat-mediated HIV elongation"/>
          </entry>
          <signature-library-release library="CDD" version="3.18"/>
        </signature>
        <model-ac>cd00043</model-ac>
        <locations>
          <rpsblast-location evalue="9.13954E-16" score="69.1896" start="109" end="191">
            <location-fragments>
              <rpsblast-location-fragment start="109" end="191" dc-status="CONTINUOUS"/>
            </location-fragments>
            <sites>
              <rpsblast-site description="binding site 2" numLocations="6">
                <site-locations>
                  <site-location residue="I" start="183" end="183"/>
                  <site-location residue="Y" start="157" end="157"/>
                  <site-location residue="R" start="161" end="161"/>
                  <site-location residue="C" start="186" end="186"/>
                  <site-location residue="F" start="187" end="187"/>
                  <site-location residue="T" start="168" end="168"/>
                </site-locations>
              </rpsblast-site>
            </sites>
          </rpsblast-location>
        </locations>
      </rpsblast-match>
      <rpsblast-match>
        <signature ac="cd00043" desc="CYCLIN" name="CYCLIN">
          <entry ac="IPR013763" desc="Cyclin-like" name="Cyclin-like" type="DOMAIN">
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            <pathway-xref db="Reactome" id="R-DME-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-MMU-2565942" name="Regulation of PLK1 Activity at G2/M Transition"/>
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            <pathway-xref db="Reactome" id="R-MMU-2559586" name="DNA Damage/Telomere Stress Induced Senescence"/>
            <pathway-xref db="Reactome" id="R-MMU-171319" name="Telomere Extension By Telomerase"/>
            <pathway-xref db="Reactome" id="R-CEL-9018519" name="Estrogen-dependent gene expression"/>
            <pathway-xref db="Reactome" id="R-DME-68911" name="G2 Phase"/>
            <pathway-xref db="Reactome" id="R-RNO-6796648" name="TP53 Regulates Transcription of DNA Repair Genes"/>
            <pathway-xref db="Reactome" id="R-SPO-75955" name="RNA Polymerase II Transcription Elongation"/>
            <pathway-xref db="Reactome" id="R-SCE-113418" name="Formation of the Early Elongation Complex"/>
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        </signature>
        <model-ac>cd00043</model-ac>
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                <site-locations>
                  <site-location residue="Y" start="252" end="252"/>
                  <site-location residue="Q" start="256" end="256"/>
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                  <site-location residue="Y" start="282" end="282"/>
                  <site-location residue="S" start="263" end="263"/>
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              </rpsblast-site>
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        <signature ac="SSF57783" name="Zinc beta-ribbon">
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        <model-ac>0045780</model-ac>
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            <pathway-xref db="Reactome" id="R-CEL-76042" name="RNA Polymerase II Transcription Initiation And Promoter Clearance"/>
            <pathway-xref db="Reactome" id="R-RNO-2980767" name="Activation of NIMA Kinases NEK9, NEK6, NEK7"/>
            <pathway-xref db="Reactome" id="R-HSA-5687128" name="MAPK6/MAPK4 signaling"/>
            <pathway-xref db="Reactome" id="R-HSA-69656" name="Cyclin A:Cdk2-associated events at S phase entry"/>
            <pathway-xref db="Reactome" id="R-HSA-76071" name="RNA Polymerase III Transcription Initiation From Type 3 Promoter"/>
            <pathway-xref db="Reactome" id="R-HSA-2995383" name="Initiation of Nuclear Envelope (NE) Reformation"/>
            <pathway-xref db="Reactome" id="R-MMU-5693607" name="Processing of DNA double-strand break ends"/>
            <pathway-xref db="Reactome" id="R-MMU-6804757" name="Regulation of TP53 Degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-69478" name="G2/M DNA replication checkpoint"/>
            <pathway-xref db="Reactome" id="R-DME-2500257" name="Resolution of Sister Chromatid Cohesion"/>
            <pathway-xref db="Reactome" id="R-RNO-8957275" name="Post-translational protein phosphorylation"/>
            <pathway-xref db="Reactome" id="R-RNO-113501" name="Inhibition of replication initiation of damaged DNA by RB1/E2F1"/>
            <pathway-xref db="Reactome" id="R-SCE-73779" name="RNA Polymerase II Transcription Pre-Initiation And Promoter Opening"/>
            <pathway-xref db="Reactome" id="R-DME-174048" name="APC/C:Cdc20 mediated degradation of Cyclin B"/>
            <pathway-xref db="Reactome" id="R-RNO-6804116" name="TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest"/>
            <pathway-xref db="Reactome" id="R-RNO-176408" name="Regulation of APC/C activators between G1/S and early anaphase"/>
            <pathway-xref db="Reactome" id="R-MMU-68875" name="Mitotic Prophase"/>
            <pathway-xref db="Reactome" id="R-DME-6804756" name="Regulation of TP53 Activity through Phosphorylation"/>
            <pathway-xref db="Reactome" id="R-HSA-9031628" name="NGF-stimulated transcription"/>
            <pathway-xref db="Reactome" id="R-SPO-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-RNO-174184" name="Cdc20:Phospho-APC/C mediated degradation of Cyclin A"/>
            <pathway-xref db="Reactome" id="R-DDI-73772" name="RNA Polymerase I Promoter Escape"/>
            <pathway-xref db="Reactome" id="R-DRE-9706019" name="RHOBTB3 ATPase cycle"/>
            <pathway-xref db="Reactome" id="R-DRE-69563" name="p53-Dependent G1 DNA Damage Response"/>
            <pathway-xref db="Reactome" id="R-DDI-69231" name="Cyclin D associated events in G1"/>
            <pathway-xref db="Reactome" id="R-HSA-2559584" name="Formation of Senescence-Associated Heterochromatin Foci (SAHF)"/>
            <pathway-xref db="Reactome" id="R-MMU-69563" name="p53-Dependent G1 DNA Damage Response"/>
            <pathway-xref db="Reactome" id="R-SPO-674695" name="RNA Polymerase II Pre-transcription Events"/>
            <pathway-xref db="Reactome" id="R-HSA-113507" name="E2F-enabled inhibition of pre-replication complex formation"/>
            <pathway-xref db="Reactome" id="R-HSA-1912408" name="Pre-NOTCH Transcription and Translation"/>
            <pathway-xref db="Reactome" id="R-HSA-162658" name="Golgi Cisternae Pericentriolar Stack Reorganization"/>
            <pathway-xref db="Reactome" id="R-RNO-2173796" name="SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription"/>
            <pathway-xref db="Reactome" id="R-GGA-8934593" name="Regulation of RUNX1 Expression and Activity"/>
            <pathway-xref db="Reactome" id="R-CEL-187577" name="SCF(Skp2)-mediated degradation of p27/p21"/>
            <pathway-xref db="Reactome" id="R-DDI-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-HSA-3214858" name="RMTs methylate histone arginines"/>
            <pathway-xref db="Reactome" id="R-SPO-69202" name="Cyclin E associated events during G1/S transition"/>
            <pathway-xref db="Reactome" id="R-MMU-2559582" name="Senescence-Associated Secretory Phenotype (SASP)"/>
            <pathway-xref db="Reactome" id="R-HSA-8951664" name="Neddylation"/>
            <pathway-xref db="Reactome" id="R-CEL-75953" name="RNA Polymerase II Transcription Initiation"/>
            <pathway-xref db="Reactome" id="R-HSA-8951936" name="RUNX3 regulates p14-ARF"/>
            <pathway-xref db="Reactome" id="R-MMU-73776" name="RNA Polymerase II Promoter Escape"/>
            <pathway-xref db="Reactome" id="R-DME-3301854" name="Nuclear Pore Complex (NPC) Disassembly"/>
            <pathway-xref db="MetaCyc" id="PWY-7730" name="T-2 toxin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-2500257" name="Resolution of Sister Chromatid Cohesion"/>
            <pathway-xref db="Reactome" id="R-CEL-69563" name="p53-Dependent G1 DNA Damage Response"/>
            <pathway-xref db="Reactome" id="R-RNO-72086" name="mRNA Capping"/>
            <pathway-xref db="Reactome" id="R-SPO-8951664" name="Neddylation"/>
            <pathway-xref db="Reactome" id="R-SPO-69656" name="Cyclin A:Cdk2-associated events at S phase entry"/>
            <pathway-xref db="Reactome" id="R-SPO-68949" name="Orc1 removal from chromatin"/>
            <pathway-xref db="Reactome" id="R-HSA-427413" name="NoRC negatively regulates rRNA expression"/>
            <pathway-xref db="Reactome" id="R-HSA-73863" name="RNA Polymerase I Transcription Termination"/>
            <pathway-xref db="Reactome" id="R-DME-9018519" name="Estrogen-dependent gene expression"/>
            <pathway-xref db="Reactome" id="R-MMU-174048" name="APC/C:Cdc20 mediated degradation of Cyclin B"/>
            <pathway-xref db="Reactome" id="R-HSA-2894862" name="Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants"/>
            <pathway-xref db="Reactome" id="R-HSA-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-75953" name="RNA Polymerase II Transcription Initiation"/>
            <pathway-xref db="Reactome" id="R-RNO-171319" name="Telomere Extension By Telomerase"/>
            <pathway-xref db="Reactome" id="R-HSA-77075" name="RNA Pol II CTD phosphorylation and interaction with CE"/>
            <pathway-xref db="Reactome" id="R-DRE-2559586" name="DNA Damage/Telomere Stress Induced Senescence"/>
            <pathway-xref db="Reactome" id="R-CEL-73776" name="RNA Polymerase II Promoter Escape"/>
            <pathway-xref db="Reactome" id="R-SPO-76066" name="RNA Polymerase III Transcription Initiation From Type 2 Promoter"/>
            <pathway-xref db="Reactome" id="R-DDI-674695" name="RNA Polymerase II Pre-transcription Events"/>
            <pathway-xref db="Reactome" id="R-HSA-167287" name="HIV elongation arrest and recovery"/>
            <pathway-xref db="Reactome" id="R-RNO-9706019" name="RHOBTB3 ATPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-8934593" name="Regulation of RUNX1 Expression and Activity"/>
            <pathway-xref db="MetaCyc" id="PWY-7712" name="deoxynivalenol biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SCE-75815" name="Ubiquitin-dependent degradation of Cyclin D"/>
            <pathway-xref db="Reactome" id="R-RNO-73863" name="RNA Polymerase I Transcription Termination"/>
            <pathway-xref db="Reactome" id="R-SPO-76061" name="RNA Polymerase III Transcription Initiation From Type 1 Promoter"/>
            <pathway-xref db="Reactome" id="R-MMU-75815" name="Ubiquitin-dependent degradation of Cyclin D"/>
            <pathway-xref db="Reactome" id="R-MMU-2559584" name="Formation of Senescence-Associated Heterochromatin Foci (SAHF)"/>
            <pathway-xref db="Reactome" id="R-RNO-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-CEL-4419969" name="Depolymerisation of the Nuclear Lamina"/>
            <pathway-xref db="Reactome" id="R-RNO-77075" name="RNA Pol II CTD phosphorylation and interaction with CE"/>
            <pathway-xref db="Reactome" id="R-MMU-187577" name="SCF(Skp2)-mediated degradation of p27/p21"/>
            <pathway-xref db="Reactome" id="R-HSA-167238" name="Pausing and recovery of Tat-mediated HIV elongation"/>
          </entry>
          <signature-library-release library="SUPERFAMILY" version="1.75"/>
        </signature>
        <model-ac>0044902</model-ac>
        <locations>
          <superfamilyhmmer3-location hmm-length="109" start="201" end="308">
            <location-fragments>
              <superfamilyhmmer3-location-fragment start="201" end="308" dc-status="CONTINUOUS"/>
            </location-fragments>
          </superfamilyhmmer3-location>
        </locations>
      </superfamilyhmmer3-match>
    </matches>
  </protein>
  <protein>
    <sequence md5="96236d03b414c90dbce10b7632516079">MIPFERVALFEGPNLVELSSPLHFRNGRSAQFDSNEDDLTSLTGASQAGLLASAAAPLPSTRRRDPNQSFLDSLRGVGIASAEDQLAGASSLQGSPQGPDYVDYGAYTGKKGAFGWYSDHPVLLGYHRR</sequence>
    <xref id="TCALIF_00044-PA" name="TCALIF_00044-PA protein Name:&quot;Protein of unknown function&quot; AED:0.22 eAED:0.22 QI:145|1|1|1|1|1|2|194|129"/>
    <matches/>
  </protein>
  <protein>
    <sequence md5="f5bebbf876c98b6d165ef14274cb6f57">ACKLKTFAEKRGLQQVNPVKPFLEIIVCRHEKHIPSVPVVTSVTLLYHTSGRTEEILEADSHIIFGDLAWPKDVRTNFKIYGSESDGKRDYYTLECLLYFLKNIKRSHPDYVKQAKGEVPIVHRPDRRDLIQYLEGNLQKKDLKSLDQSAPLQMPINFKRSAREELRKSDTSFGGSAAKKPRLEHNQSEIKERLAAKLDGPQESKLSINKANLKNLSEDLTTDKIAEIRAKLISNRRTRIKPEDDDAKQTSLGLGDLEVNRESRDIFGRERVWRTRTTVLQSTGKNFSKTVTALLSSVKAREEGKMGKPHPPQAPPSVTPRPGGSMPPPQRQSLPNYNRYDQEQFRGKDDTHGFNIETMGTFSGMTLKSVTEGSQANRHKQNKGGPPTKPSGPTPAASGPNAKPGVGSASPGHSGKRPSRTPIIIIPAAPKSLITMFNAKDILQDLRFVSTEDRKAQGGKRDNELLIQRRKEGGLTVPYRVIDNPSKLTNADWDRVVAVFVMGQAWQFKGWPWEGVPVVIFSKIAAFHVKWDESTLEKNIGNWAVNVIQLSREKRHLDRAKLMSFWETLDKYMVKNKPHLRF</sequence>
    <xref id="TCALIF_00483-PB" name="TCALIF_00483-PB protein Name:&quot;Similar to CDC73 Parafibromin (Gallus gallus)&quot; AED:0.14 eAED:0.20 QI:0|0.85|0.75|1|0.85|0.75|8|143|582"/>
    <matches>
      <hmmer3-match evalue="9.3E-84" score="281.3">
        <signature ac="PF16050" desc="Paf1 complex subunit CDC73 N-terminal" name="CDC73_N">
          <entry ac="IPR032041" desc="Paf1 complex subunit Cdc73, N-terminal domain" name="Cdc73_N" type="DOMAIN">
            <pathway-xref db="Reactome" id="R-RNO-201722" name="Formation of the beta-catenin:TCF transactivating complex"/>
            <pathway-xref db="Reactome" id="R-RNO-112382" name="Formation of RNA Pol II elongation complex"/>
            <pathway-xref db="Reactome" id="R-GGA-201722" name="Formation of the beta-catenin:TCF transactivating complex"/>
            <pathway-xref db="Reactome" id="R-RNO-75955" name="RNA Polymerase II Transcription Elongation"/>
            <pathway-xref db="Reactome" id="R-GGA-75955" name="RNA Polymerase II Transcription Elongation"/>
            <pathway-xref db="Reactome" id="R-MMU-8866654" name="E3 ubiquitin ligases ubiquitinate target proteins"/>
            <pathway-xref db="Reactome" id="R-MMU-112382" name="Formation of RNA Pol II elongation complex"/>
            <pathway-xref db="Reactome" id="R-CEL-75955" name="RNA Polymerase II Transcription Elongation"/>
            <pathway-xref db="Reactome" id="R-HSA-674695" name="RNA Polymerase II Pre-transcription Events"/>
            <pathway-xref db="Reactome" id="R-CEL-201722" name="Formation of the beta-catenin:TCF transactivating complex"/>
            <pathway-xref db="Reactome" id="R-MMU-201722" name="Formation of the beta-catenin:TCF transactivating complex"/>
            <pathway-xref db="Reactome" id="R-HSA-75955" name="RNA Polymerase II Transcription Elongation"/>
            <pathway-xref db="Reactome" id="R-HSA-8866654" name="E3 ubiquitin ligases ubiquitinate target proteins"/>
            <pathway-xref db="Reactome" id="R-RNO-8866654" name="E3 ubiquitin ligases ubiquitinate target proteins"/>
            <pathway-xref db="Reactome" id="R-CEL-112382" name="Formation of RNA Pol II elongation complex"/>
            <pathway-xref db="Reactome" id="R-GGA-674695" name="RNA Polymerase II Pre-transcription Events"/>
            <pathway-xref db="Reactome" id="R-HSA-201722" name="Formation of the beta-catenin:TCF transactivating complex"/>
            <pathway-xref db="Reactome" id="R-RNO-674695" name="RNA Polymerase II Pre-transcription Events"/>
            <pathway-xref db="Reactome" id="R-MMU-75955" name="RNA Polymerase II Transcription Elongation"/>
            <pathway-xref db="Reactome" id="R-CEL-674695" name="RNA Polymerase II Pre-transcription Events"/>
            <pathway-xref db="Reactome" id="R-RNO-5632684" name="Hedgehog 'on' state"/>
            <pathway-xref db="Reactome" id="R-HSA-5632684" name="Hedgehog 'on' state"/>
            <pathway-xref db="Reactome" id="R-MMU-674695" name="RNA Polymerase II Pre-transcription Events"/>
            <pathway-xref db="Reactome" id="R-MMU-5632684" name="Hedgehog 'on' state"/>
            <pathway-xref db="Reactome" id="R-HSA-112382" name="Formation of RNA Pol II elongation complex"/>
          </entry>
          <signature-library-release library="PFAM" version="34.0"/>
        </signature>
        <model-ac>PF16050</model-ac>
        <locations>
          <hmmer3-location env-end="344" env-start="40" post-processed="true" score="280.8" evalue="1.3E-83" hmm-start="14" hmm-end="300" hmm-length="301" hmm-bounds="INCOMPLETE" start="52" end="343">
            <location-fragments>
              <hmmer3-location-fragment start="52" end="343" dc-status="CONTINUOUS"/>
            </location-fragments>
          </hmmer3-location>
        </locations>
      </hmmer3-match>
      <hmmer3-match evalue="4.9E-50" score="169.3">
        <signature ac="PF05179" desc="RNA pol II accessory factor, Cdc73 family, C-terminal" name="CDC73_C">
          <entry ac="IPR031336" desc="Cell division control protein 73, C-terminal" name="CDC73_C" type="DOMAIN">
            <pathway-xref db="Reactome" id="R-RNO-201722" name="Formation of the beta-catenin:TCF transactivating complex"/>
            <pathway-xref db="Reactome" id="R-RNO-112382" name="Formation of RNA Pol II elongation complex"/>
            <pathway-xref db="Reactome" id="R-GGA-201722" name="Formation of the beta-catenin:TCF transactivating complex"/>
            <pathway-xref db="Reactome" id="R-RNO-75955" name="RNA Polymerase II Transcription Elongation"/>
            <pathway-xref db="Reactome" id="R-GGA-75955" name="RNA Polymerase II Transcription Elongation"/>
            <pathway-xref db="Reactome" id="R-MMU-8866654" name="E3 ubiquitin ligases ubiquitinate target proteins"/>
            <pathway-xref db="Reactome" id="R-MMU-112382" name="Formation of RNA Pol II elongation complex"/>
            <pathway-xref db="Reactome" id="R-CEL-75955" name="RNA Polymerase II Transcription Elongation"/>
            <pathway-xref db="Reactome" id="R-HSA-674695" name="RNA Polymerase II Pre-transcription Events"/>
            <pathway-xref db="Reactome" id="R-CEL-201722" name="Formation of the beta-catenin:TCF transactivating complex"/>
            <pathway-xref db="Reactome" id="R-MMU-201722" name="Formation of the beta-catenin:TCF transactivating complex"/>
            <pathway-xref db="Reactome" id="R-SPO-674695" name="RNA Polymerase II Pre-transcription Events"/>
            <pathway-xref db="Reactome" id="R-SCE-674695" name="RNA Polymerase II Pre-transcription Events"/>
            <pathway-xref db="Reactome" id="R-SCE-75955" name="RNA Polymerase II Transcription Elongation"/>
            <pathway-xref db="Reactome" id="R-HSA-75955" name="RNA Polymerase II Transcription Elongation"/>
            <pathway-xref db="Reactome" id="R-HSA-8866654" name="E3 ubiquitin ligases ubiquitinate target proteins"/>
            <pathway-xref db="Reactome" id="R-RNO-8866654" name="E3 ubiquitin ligases ubiquitinate target proteins"/>
            <pathway-xref db="Reactome" id="R-CEL-112382" name="Formation of RNA Pol II elongation complex"/>
            <pathway-xref db="Reactome" id="R-GGA-674695" name="RNA Polymerase II Pre-transcription Events"/>
            <pathway-xref db="Reactome" id="R-HSA-201722" name="Formation of the beta-catenin:TCF transactivating complex"/>
            <pathway-xref db="Reactome" id="R-RNO-674695" name="RNA Polymerase II Pre-transcription Events"/>
            <pathway-xref db="Reactome" id="R-MMU-75955" name="RNA Polymerase II Transcription Elongation"/>
            <pathway-xref db="Reactome" id="R-CEL-674695" name="RNA Polymerase II Pre-transcription Events"/>
            <pathway-xref db="Reactome" id="R-RNO-5632684" name="Hedgehog 'on' state"/>
            <pathway-xref db="Reactome" id="R-HSA-5632684" name="Hedgehog 'on' state"/>
            <pathway-xref db="Reactome" id="R-MMU-674695" name="RNA Polymerase II Pre-transcription Events"/>
            <pathway-xref db="Reactome" id="R-SPO-75955" name="RNA Polymerase II Transcription Elongation"/>
            <pathway-xref db="Reactome" id="R-MMU-5632684" name="Hedgehog 'on' state"/>
            <pathway-xref db="Reactome" id="R-HSA-112382" name="Formation of RNA Pol II elongation complex"/>
          </entry>
          <signature-library-release library="PFAM" version="34.0"/>
        </signature>
        <model-ac>PF05179</model-ac>
        <locations>
          <hmmer3-location env-end="572" env-start="418" post-processed="true" score="168.4" evalue="9.1E-50" hmm-start="2" hmm-end="157" hmm-length="158" hmm-bounds="INCOMPLETE" start="419" end="571">
            <location-fragments>
              <hmmer3-location-fragment start="419" end="571" dc-status="CONTINUOUS"/>
            </location-fragments>
          </hmmer3-location>
        </locations>
      </hmmer3-match>
      <hmmer3-match evalue="5.2E-55" score="187.4">
        <signature ac="G3DSA:3.40.50.11990" name="">
          <entry ac="IPR038103" desc="Cell division control protein 73, C-terminal domain superfamily" name="CDC73_C_sf" type="HOMOLOGOUS_SUPERFAMILY">
            <pathway-xref db="Reactome" id="R-RNO-201722" name="Formation of the beta-catenin:TCF transactivating complex"/>
            <pathway-xref db="Reactome" id="R-RNO-112382" name="Formation of RNA Pol II elongation complex"/>
            <pathway-xref db="Reactome" id="R-GGA-201722" name="Formation of the beta-catenin:TCF transactivating complex"/>
            <pathway-xref db="Reactome" id="R-RNO-75955" name="RNA Polymerase II Transcription Elongation"/>
            <pathway-xref db="Reactome" id="R-GGA-75955" name="RNA Polymerase II Transcription Elongation"/>
            <pathway-xref db="Reactome" id="R-MMU-8866654" name="E3 ubiquitin ligases ubiquitinate target proteins"/>
            <pathway-xref db="Reactome" id="R-MMU-112382" name="Formation of RNA Pol II elongation complex"/>
            <pathway-xref db="Reactome" id="R-CEL-75955" name="RNA Polymerase II Transcription Elongation"/>
            <pathway-xref db="Reactome" id="R-HSA-674695" name="RNA Polymerase II Pre-transcription Events"/>
            <pathway-xref db="Reactome" id="R-CEL-201722" name="Formation of the beta-catenin:TCF transactivating complex"/>
            <pathway-xref db="Reactome" id="R-MMU-201722" name="Formation of the beta-catenin:TCF transactivating complex"/>
            <pathway-xref db="Reactome" id="R-SPO-674695" name="RNA Polymerase II Pre-transcription Events"/>
            <pathway-xref db="Reactome" id="R-SCE-674695" name="RNA Polymerase II Pre-transcription Events"/>
            <pathway-xref db="Reactome" id="R-SCE-75955" name="RNA Polymerase II Transcription Elongation"/>
            <pathway-xref db="Reactome" id="R-HSA-75955" name="RNA Polymerase II Transcription Elongation"/>
            <pathway-xref db="Reactome" id="R-HSA-8866654" name="E3 ubiquitin ligases ubiquitinate target proteins"/>
            <pathway-xref db="Reactome" id="R-RNO-8866654" name="E3 ubiquitin ligases ubiquitinate target proteins"/>
            <pathway-xref db="Reactome" id="R-GGA-674695" name="RNA Polymerase II Pre-transcription Events"/>
            <pathway-xref db="Reactome" id="R-CEL-112382" name="Formation of RNA Pol II elongation complex"/>
            <pathway-xref db="Reactome" id="R-HSA-201722" name="Formation of the beta-catenin:TCF transactivating complex"/>
            <pathway-xref db="Reactome" id="R-RNO-674695" name="RNA Polymerase II Pre-transcription Events"/>
            <pathway-xref db="Reactome" id="R-MMU-75955" name="RNA Polymerase II Transcription Elongation"/>
            <pathway-xref db="Reactome" id="R-CEL-674695" name="RNA Polymerase II Pre-transcription Events"/>
            <pathway-xref db="Reactome" id="R-RNO-5632684" name="Hedgehog 'on' state"/>
            <pathway-xref db="Reactome" id="R-HSA-5632684" name="Hedgehog 'on' state"/>
            <pathway-xref db="Reactome" id="R-MMU-674695" name="RNA Polymerase II Pre-transcription Events"/>
            <pathway-xref db="Reactome" id="R-SPO-75955" name="RNA Polymerase II Transcription Elongation"/>
            <pathway-xref db="Reactome" id="R-MMU-5632684" name="Hedgehog 'on' state"/>
            <pathway-xref db="Reactome" id="R-HSA-112382" name="Formation of RNA Pol II elongation complex"/>
          </entry>
          <signature-library-release library="GENE3D" version="4.3.0"/>
        </signature>
        <model-ac>3v46A00</model-ac>
        <locations>
          <hmmer3-location env-end="577" env-start="409" post-processed="true" score="186.7" evalue="9.1E-55" hmm-start="7" hmm-end="166" hmm-length="170" hmm-bounds="COMPLETE" start="409" end="577">
            <location-fragments>
              <hmmer3-location-fragment start="409" end="577" dc-status="CONTINUOUS"/>
            </location-fragments>
          </hmmer3-location>
        </locations>
      </hmmer3-match>
      <mobidblite-match>
        <signature ac="mobidb-lite" desc="consensus disorder prediction" name="disorder_prediction">
          <signature-library-release library="MOBIDB_LITE" version="2.0"/>
        </signature>
        <model-ac>mobidb-lite</model-ac>
        <locations>
          <mobidblite-location sequence-feature="Proline-rich" start="309" end="329">
            <location-fragments>
              <mobidblite-location-fragment start="309" end="329" dc-status="CONTINUOUS"/>
            </location-fragments>
          </mobidblite-location>
        </locations>
      </mobidblite-match>
      <mobidblite-match>
        <signature ac="mobidb-lite" desc="consensus disorder prediction" name="disorder_prediction">
          <signature-library-release library="MOBIDB_LITE" version="2.0"/>
        </signature>
        <model-ac>mobidb-lite</model-ac>
        <locations>
          <mobidblite-location sequence-feature="Polar" start="356" end="384">
            <location-fragments>
              <mobidblite-location-fragment start="356" end="384" dc-status="CONTINUOUS"/>
            </location-fragments>
          </mobidblite-location>
        </locations>
      </mobidblite-match>
      <mobidblite-match>
        <signature ac="mobidb-lite" desc="consensus disorder prediction" name="disorder_prediction">
          <signature-library-release library="MOBIDB_LITE" version="2.0"/>
        </signature>
        <model-ac>mobidb-lite</model-ac>
        <locations>
          <mobidblite-location sequence-feature="" start="298" end="423">
            <location-fragments>
              <mobidblite-location-fragment start="298" end="423" dc-status="CONTINUOUS"/>
            </location-fragments>
          </mobidblite-location>
        </locations>
      </mobidblite-match>
      <panther-match evalue="1.9E-107" familyName="CDC73 DOMAIN PROTEIN" score="371.8">
        <signature ac="PTHR12466" name="CDC73 DOMAIN PROTEIN">
          <entry ac="IPR007852" desc="Cdc73/Parafibromin" name="Cdc73/Parafibromin" type="FAMILY">
            <go-xref category="CELLULAR_COMPONENT" db="GO" id="GO:0016593" name="Cdc73/Paf1 complex"/>
            <go-xref category="BIOLOGICAL_PROCESS" db="GO" id="GO:0006368" name="transcription elongation from RNA polymerase II promoter"/>
            <go-xref category="BIOLOGICAL_PROCESS" db="GO" id="GO:0016570" name="histone modification"/>
            <pathway-xref db="Reactome" id="R-RNO-201722" name="Formation of the beta-catenin:TCF transactivating complex"/>
            <pathway-xref db="Reactome" id="R-RNO-112382" name="Formation of RNA Pol II elongation complex"/>
            <pathway-xref db="Reactome" id="R-GGA-201722" name="Formation of the beta-catenin:TCF transactivating complex"/>
            <pathway-xref db="Reactome" id="R-RNO-75955" name="RNA Polymerase II Transcription Elongation"/>
            <pathway-xref db="Reactome" id="R-GGA-75955" name="RNA Polymerase II Transcription Elongation"/>
            <pathway-xref db="Reactome" id="R-MMU-8866654" name="E3 ubiquitin ligases ubiquitinate target proteins"/>
            <pathway-xref db="Reactome" id="R-MMU-112382" name="Formation of RNA Pol II elongation complex"/>
            <pathway-xref db="Reactome" id="R-CEL-75955" name="RNA Polymerase II Transcription Elongation"/>
            <pathway-xref db="Reactome" id="R-HSA-674695" name="RNA Polymerase II Pre-transcription Events"/>
            <pathway-xref db="Reactome" id="R-CEL-201722" name="Formation of the beta-catenin:TCF transactivating complex"/>
            <pathway-xref db="Reactome" id="R-MMU-201722" name="Formation of the beta-catenin:TCF transactivating complex"/>
            <pathway-xref db="Reactome" id="R-SPO-674695" name="RNA Polymerase II Pre-transcription Events"/>
            <pathway-xref db="Reactome" id="R-SCE-674695" name="RNA Polymerase II Pre-transcription Events"/>
            <pathway-xref db="Reactome" id="R-SCE-75955" name="RNA Polymerase II Transcription Elongation"/>
            <pathway-xref db="Reactome" id="R-HSA-75955" name="RNA Polymerase II Transcription Elongation"/>
            <pathway-xref db="Reactome" id="R-HSA-8866654" name="E3 ubiquitin ligases ubiquitinate target proteins"/>
            <pathway-xref db="Reactome" id="R-RNO-8866654" name="E3 ubiquitin ligases ubiquitinate target proteins"/>
            <pathway-xref db="Reactome" id="R-CEL-112382" name="Formation of RNA Pol II elongation complex"/>
            <pathway-xref db="Reactome" id="R-GGA-674695" name="RNA Polymerase II Pre-transcription Events"/>
            <pathway-xref db="Reactome" id="R-HSA-201722" name="Formation of the beta-catenin:TCF transactivating complex"/>
            <pathway-xref db="Reactome" id="R-RNO-674695" name="RNA Polymerase II Pre-transcription Events"/>
            <pathway-xref db="Reactome" id="R-MMU-75955" name="RNA Polymerase II Transcription Elongation"/>
            <pathway-xref db="Reactome" id="R-CEL-674695" name="RNA Polymerase II Pre-transcription Events"/>
            <pathway-xref db="Reactome" id="R-RNO-5632684" name="Hedgehog 'on' state"/>
            <pathway-xref db="Reactome" id="R-HSA-5632684" name="Hedgehog 'on' state"/>
            <pathway-xref db="Reactome" id="R-MMU-674695" name="RNA Polymerase II Pre-transcription Events"/>
            <pathway-xref db="Reactome" id="R-SPO-75955" name="RNA Polymerase II Transcription Elongation"/>
            <pathway-xref db="Reactome" id="R-MMU-5632684" name="Hedgehog 'on' state"/>
            <pathway-xref db="Reactome" id="R-HSA-112382" name="Formation of RNA Pol II elongation complex"/>
          </entry>
          <signature-library-release library="PANTHER" version="15.0"/>
        </signature>
        <model-ac>PTHR12466</model-ac>
        <locations>
          <panther-location env-start="40" env-end="581" hmm-start="9" hmm-end="399" hmm-length="404" hmm-bounds="INCOMPLETE" start="46" end="577">
            <location-fragments>
              <panther-location-fragment start="46" end="577" dc-status="CONTINUOUS"/>
            </location-fragments>
          </panther-location>
        </locations>
      </panther-match>
    </matches>
  </protein>
  <protein>
    <sequence md5="2e6e4d43372415df42da60e87efc5419">MSTERELALIQLDHSYAKPWNWRPEALPVIKPAKSLFMTRQPGPPYSLALPVNTDEEIDVLTPIAPNKNPLEEKTQQIMTECERFADLVNPDVKSLAQVEDWEERVCKDSWTTAQHRLFNRVLKVFHADRLARLAQDSHPREPIQRRLVIDKTAKRVRLLLAQILWDPKLTHWLHNALCDNLPREYIAIYLDVLQTLRKKVPELIDKLLAGRVHPDQYGSCTKEGFRLLMKRKWDPTVAEYLHAPKIKKLPNNPFIILTPSAPQDNSQLSSRAQMWTKMLMTVGKLVTITLPTLKEADSAEVQKTEISRFIQRVVSVTITRIRDIKRSGHQDRPIFLFGWGVAAAINCQIASMETVSGCVCLGFPLSTLAGMRGEVDDPCLLDIKSPVLFVAGQNAVDCKPDDLEDVREKMRCESGLVLVGGADFQLRVSKHKKKAEAITQSMVDRAIMDEIREFLQNLMVPTVPAPTAVQMQATVMMDGSPMPTVAKKPARPRKKREEGSPAPKRAKSNKTKAALATAALNAANNGNPTSTPPMPIVGASITPTGDSSVVGVGSIATSTPVRSIPGIDVTKARKALEMGDTSSPLLSSALTSPTKTTALSGLKTTPTFTTPLLAHSSGISVSKGSRVARPMVPIGLPTTPVPASTISNYISGSSSPIPSGSVPSGMSHSSLTRPLPTPLVTSRIVSPPKVGSPSSTIIKTVSGAISSPPVSTPPTTKRITPQSELSTSNMIFLSQSAGGGNLTMAQRIVTTLPATASTPSIKTAASTPNQTLTVPSSLAQSLGVKKPGGGSKESLYIVAVPPDQIKNLESNNLIQYSGPKGNQMVALLSPEKGTPPSSANKVINVSADMKQSTNTTADGQGTEKRNVAEILASLSGLTPDPPKADISKIVKTINLPESTSVRPISMTPPVSSGASTPITNAPPTSSSSVMAVKSSPGRSTASILSSGGGRVVRVLTTSGNRTMQQSPSIIRSPSGSSVASATVSSSPSTSGGTNRSRKQVFVTQEKTEESTSPSTSMSKAEKAPEVITSVTTGDVAVVKEDDGAKIQKIKETHIGEKDILEEDMDDQEYVPYQKKPKKVTRSSTSSSKN</sequence>
    <xref id="TCALIF_00039-PA" name="TCALIF_00039-PA protein Name:&quot;Similar to Kansl3 KAT8 regulatory NSL complex subunit 3 (Mus musculus)&quot; AED:0.34 eAED:0.40 QI:0|0|0|0.5|1|1|8|0|1090"/>
    <matches>
      <mobidblite-match>
        <signature ac="mobidb-lite" desc="consensus disorder prediction" name="disorder_prediction">
          <signature-library-release library="MOBIDB_LITE" version="2.0"/>
        </signature>
        <model-ac>mobidb-lite</model-ac>
        <locations>
          <mobidblite-location sequence-feature="" start="479" end="534">
            <location-fragments>
              <mobidblite-location-fragment start="479" end="534" dc-status="CONTINUOUS"/>
            </location-fragments>
          </mobidblite-location>
        </locations>
      </mobidblite-match>
      <mobidblite-match>
        <signature ac="mobidb-lite" desc="consensus disorder prediction" name="disorder_prediction">
          <signature-library-release library="MOBIDB_LITE" version="2.0"/>
        </signature>
        <model-ac>mobidb-lite</model-ac>
        <locations>
          <mobidblite-location sequence-feature="Polyampholyte" start="492" end="506">
            <location-fragments>
              <mobidblite-location-fragment start="492" end="506" dc-status="CONTINUOUS"/>
            </location-fragments>
          </mobidblite-location>
        </locations>
      </mobidblite-match>
      <mobidblite-match>
        <signature ac="mobidb-lite" desc="consensus disorder prediction" name="disorder_prediction">
          <signature-library-release library="MOBIDB_LITE" version="2.0"/>
        </signature>
        <model-ac>mobidb-lite</model-ac>
        <locations>
          <mobidblite-location sequence-feature="Polar" start="515" end="534">
            <location-fragments>
              <mobidblite-location-fragment start="515" end="534" dc-status="CONTINUOUS"/>
            </location-fragments>
          </mobidblite-location>
        </locations>
      </mobidblite-match>
      <mobidblite-match>
        <signature ac="mobidb-lite" desc="consensus disorder prediction" name="disorder_prediction">
          <signature-library-release library="MOBIDB_LITE" version="2.0"/>
        </signature>
        <model-ac>mobidb-lite</model-ac>
        <locations>
          <mobidblite-location sequence-feature="Polar" start="905" end="1023">
            <location-fragments>
              <mobidblite-location-fragment start="905" end="1023" dc-status="CONTINUOUS"/>
            </location-fragments>
          </mobidblite-location>
        </locations>
      </mobidblite-match>
      <mobidblite-match>
        <signature ac="mobidb-lite" desc="consensus disorder prediction" name="disorder_prediction">
          <signature-library-release library="MOBIDB_LITE" version="2.0"/>
        </signature>
        <model-ac>mobidb-lite</model-ac>
        <locations>
          <mobidblite-location sequence-feature="" start="905" end="1027">
            <location-fragments>
              <mobidblite-location-fragment start="905" end="1027" dc-status="CONTINUOUS"/>
            </location-fragments>
          </mobidblite-location>
        </locations>
      </mobidblite-match>
      <mobidblite-match>
        <signature ac="mobidb-lite" desc="consensus disorder prediction" name="disorder_prediction">
          <signature-library-release library="MOBIDB_LITE" version="2.0"/>
        </signature>
        <model-ac>mobidb-lite</model-ac>
        <locations>
          <mobidblite-location sequence-feature="" start="1058" end="1090">
            <location-fragments>
              <mobidblite-location-fragment start="1058" end="1090" dc-status="CONTINUOUS"/>
            </location-fragments>
          </mobidblite-location>
        </locations>
      </mobidblite-match>
      <panther-match evalue="6.0E-112" familyName="TESTIS DEVELOPMENT PROTEIN PRTD" score="387.2">
        <signature ac="PTHR13136" name="TESTIS DEVELOPMENT PROTEIN PRTD">
          <entry ac="IPR026555" desc="KAT8 regulatory NSL complex subunit 3/Testis-expressed sequence 30 protein" name="NSL3/Tex30" type="FAMILY">
            <pathway-xref db="Reactome" id="R-RNO-3214847" name="HATs acetylate histones"/>
            <pathway-xref db="Reactome" id="R-HSA-3214847" name="HATs acetylate histones"/>
            <pathway-xref db="Reactome" id="R-MMU-3214847" name="HATs acetylate histones"/>
          </entry>
          <signature-library-release library="PANTHER" version="15.0"/>
        </signature>
        <model-ac>PTHR13136</model-ac>
        <locations>
          <panther-location env-start="1" env-end="1040" hmm-start="9" hmm-end="546" hmm-length="569" hmm-bounds="INCOMPLETE" start="11" end="1024">
            <location-fragments>
              <panther-location-fragment start="11" end="1024" dc-status="CONTINUOUS"/>
            </location-fragments>
          </panther-location>
        </locations>
      </panther-match>
      <superfamilyhmmer3-match evalue="5.14E-5">
        <signature ac="SSF53474" name="alpha/beta-Hydrolases">
          <entry ac="IPR029058" desc="Alpha/Beta hydrolase fold" name="AB_hydrolase" type="HOMOLOGOUS_SUPERFAMILY">
            <pathway-xref db="MetaCyc" id="PWY-8238" name="24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)"/>
            <pathway-xref db="MetaCyc" id="PWY-8022" name="salmochelin degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7325" name="salvigenin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7382" name="lipoate biosynthesis and incorporation IV (yeast)"/>
            <pathway-xref db="MetaCyc" id="PWY-7133" name="quercetin glucoside degradation (Allium)"/>
            <pathway-xref db="MetaCyc" id="PWY-8035" name="streptovaricin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7629" name="yatein biosynthesis II"/>
            <pathway-xref db="MetaCyc" id="PWY-7583" name="arachidonate biosynthesis II (bacteria)"/>
            <pathway-xref db="MetaCyc" id="PWY-6068" name="indican biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6973" name="dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7049" name="icosapentaenoate biosynthesis II (6-desaturase, mammals)"/>
            <pathway-xref db="MetaCyc" id="PWY-6646" name="fluoroacetate degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7757" name="bisphenol A degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-211945" name="Phase I - Functionalization of compounds"/>
            <pathway-xref db="MetaCyc" id="PWY-7460" name="2-O-acetyl-3-O-trans-coutarate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8224" name="Escherichia coli serotype O:157/Salmonella enterica serotype O:30 O antigen biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5310" name="superpathway of anthocyanin biosynthesis (from delphinidin 3-O-glucoside)"/>
            <pathway-xref db="MetaCyc" id="PWY-8100" name="crotonosine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7888" name="tRNA-uridine 2-thiolation (cytoplasmic)"/>
            <pathway-xref db="MetaCyc" id="PWY-6802" name="salidroside biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7582" name="mercaptosuccinate degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7631" name="arctigenin and isoarctigenin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6583" name="pyruvate fermentation to butanol I"/>
            <pathway-xref db="Reactome" id="R-HSA-1482883" name="Acyl chain remodeling of DAG and TAG"/>
            <pathway-xref db="MetaCyc" id="PWY-8051" name="anandamide biosynthesis I"/>
            <pathway-xref db="Reactome" id="R-HSA-211945" name="Phase I - Functionalization of compounds"/>
            <pathway-xref db="MetaCyc" id="PWY-8143" name="L-ascorbate biosynthesis VII (plants, D-galacturonate pathway)"/>
            <pathway-xref db="MetaCyc" id="PWY-7556" name="(-)-microperfuranone biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7782" name="plasmalogen biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6069" name="indigo biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-862" name="fructan degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-6392" name="meso-butanediol biosynthesis II"/>
            <pathway-xref db="Reactome" id="R-DME-8964038" name="LDL clearance"/>
            <pathway-xref db="MetaCyc" id="PWY-5954" name="(1'S,5'S)-averufin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7824" name="prunasin and amygdalin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-8964058" name="HDL remodeling"/>
            <pathway-xref db="Reactome" id="R-RNO-6794361" name="Neurexins and neuroligins"/>
            <pathway-xref db="MetaCyc" id="PWY-7163" name="polymethylated kaempferol biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7465" name="3,3'-thiodipropanoate degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7542" name="fumiquinazoline D biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5312" name="superpathway of anthocyanin biosynthesis (from pelargonidin 3-O-glucoside)"/>
            <pathway-xref db="MetaCyc" id="PWY-7663" name="gondoate biosynthesis (anaerobic)"/>
            <pathway-xref db="MetaCyc" id="PWY-6803" name="phosphatidylcholine acyl editing"/>
            <pathway-xref db="MetaCyc" id="PWY-641" name="proanthocyanidins biosynthesis from flavanols"/>
            <pathway-xref db="MetaCyc" id="PWY-2002" name="isoflavonoid biosynthesis I"/>
            <pathway-xref db="MetaCyc" id="PWY-5978" name="kanosamine biosynthesis I"/>
            <pathway-xref db="MetaCyc" id="PWY-8231" name="Escherichia coli serotype O:127 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-112311" name="Neurotransmitter clearance"/>
            <pathway-xref db="MetaCyc" id="PWY-7521" name="3-(4-sulfophenyl)butanoate degradation"/>
            <pathway-xref db="Reactome" id="R-DME-6809371" name="Formation of the cornified envelope"/>
            <pathway-xref db="MetaCyc" id="PWY-6089" name="3-chlorocatechol degradation I (ortho)"/>
            <pathway-xref db="MetaCyc" id="PWY-5320" name="kaempferol glycoside biosynthesis (Arabidopsis)"/>
            <pathway-xref db="MetaCyc" id="PWY-6282" name="palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate)"/>
            <pathway-xref db="MetaCyc" id="PWY-7820" name="teichuronic acid biosynthesis (B. subtilis 168)"/>
            <pathway-xref db="MetaCyc" id="PWY-7657" name="dTDP-beta-L-digitoxose biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5883" name="ephedrine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7714" name="harzianum A and trichodermin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7850" name="taurine biosynthesis II"/>
            <pathway-xref db="MetaCyc" id="PWY-7858" name="(5Z)-dodecenoate biosynthesis II"/>
            <pathway-xref db="MetaCyc" id="PWY-5987" name="sorgoleone biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7606" name="docosahexaenoate biosynthesis III (6-desaturase, mammals)"/>
            <pathway-xref db="Reactome" id="R-RNO-75105" name="Fatty acyl-CoA biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8228" name="Porphyromonas gingivalis O-LPS antigen biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-81" name="toluene degradation to benzoyl-CoA (anaerobic)"/>
            <pathway-xref db="MetaCyc" id="PWY-8218" name="Escherichia coli serotype O:56 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SSC-156590" name="Glutathione conjugation"/>
            <pathway-xref db="MetaCyc" id="PWY-7532" name="acetylaszonalenin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-112311" name="Neurotransmitter clearance"/>
            <pathway-xref db="MetaCyc" id="PWY-8053" name="anandamide biosynthesis II"/>
            <pathway-xref db="MetaCyc" id="PWY-5927" name="(4S)-carveol and (4S)-dihydrocarveol degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-5835" name="geranyl acetate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7338" name="10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast)"/>
            <pathway-xref db="MetaCyc" id="PWY-7591" name="okenone biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8049" name="pederin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6036" name="cardenolide glucosides biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8019" name="2-hydroxyparaconate and itatartarate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5830" name="CDP-ascarylose biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6094" name="3,4,6-trichlorocatechol degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-6011" name="amygdalin and prunasin degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7612" name="chaetoglobosin A biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7797" name="nocardicin A biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8219" name="Escherichia coli serotype O:107 O antigen biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5397" name="crocetin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5800" name="xylan biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7605" name="roquefortine C biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7671" name="saframycin A biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8214" name="3-sulfopropanediol degradation II"/>
            <pathway-xref db="MetaCyc" id="PWY-6801" name="volatile esters biosynthesis (during fruit ripening)"/>
            <pathway-xref db="MetaCyc" id="PWY-6658" name="acetan biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7693" name="guadinomine B biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9648002" name="RAS processing"/>
            <pathway-xref db="Reactome" id="R-MMU-203615" name="eNOS activation"/>
            <pathway-xref db="MetaCyc" id="PWY-6749" name="CMP-legionaminate biosynthesis I"/>
            <pathway-xref db="Reactome" id="R-MMU-9648002" name="RAS processing"/>
            <pathway-xref db="MetaCyc" id="PWY-8166" name="emodin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5163" name="p-cumate degradation to 2-hydroxypentadienoate"/>
            <pathway-xref db="MetaCyc" id="PWY-7774" name="propane degradation I"/>
            <pathway-xref db="MetaCyc" id="PWY-7745" name="p-HBAD biosynthesis"/>
            <pathway-xref db="Reactome" id="R-XTR-9648002" name="RAS processing"/>
            <pathway-xref db="Reactome" id="R-RNO-373760" name="L1CAM interactions"/>
            <pathway-xref db="MetaCyc" id="PWY-7071" name="steviol glucoside biosynthesis (rebaudioside A biosynthesis)"/>
            <pathway-xref db="MetaCyc" id="PWY-5343" name="ajugose biosynthesis II (galactinol-independent)"/>
            <pathway-xref db="MetaCyc" id="PWY-2055" name="superpathway of pterocarpan biosynthesis (via daidzein)"/>
            <pathway-xref db="MetaCyc" id="PWY-7989" name="acinetoferrin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7300" name="ecdysone and 20-hydroxyecdysone biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7677" name="rosamicin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7261" name="anthocyanidin 3-malylglucoside biosynthesis (acyl-glucose dependent)"/>
            <pathway-xref db="Reactome" id="R-MMU-1482883" name="Acyl chain remodeling of DAG and TAG"/>
            <pathway-xref db="MetaCyc" id="PWY-6286" name="spheroidene and spheroidenone biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8279" name="palmitate biosynthesis III"/>
            <pathway-xref db="MetaCyc" id="PWY-7585" name="docosahexaenoate biosynthesis II (bacteria)"/>
            <pathway-xref db="MetaCyc" id="PWY-7695" name="aurofusarin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-418346" name="Platelet homeostasis"/>
            <pathway-xref db="MetaCyc" id="PWY-8293" name="alazopeptin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5751" name="phenylethanol biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-199220" name="Vitamin B5 (pantothenate) metabolism"/>
            <pathway-xref db="MetaCyc" id="PWY-6739" name="pinitol biosynthesis II"/>
            <pathway-xref db="MetaCyc" id="PWY-5353" name="arachidonate biosynthesis I (6-desaturase, lower eukaryotes)"/>
            <pathway-xref db="MetaCyc" id="PWY-6107" name="chlorosalicylate degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-5773" name="gossypol biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8248" name="lipid A-core biosynthesis (P. gingivalis)"/>
            <pathway-xref db="Reactome" id="R-MMU-2142670" name="Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)"/>
            <pathway-xref db="MetaCyc" id="PWY-7702" name="sch210971 and sch210972 biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5479" name="6-methoxypodophyllotoxin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7668" name="apicidin F biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6154" name="autoinducer AI-2 biosynthesis II (Vibrio)"/>
            <pathway-xref db="MetaCyc" id="PWY-8132" name="S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation III"/>
            <pathway-xref db="MetaCyc" id="PWY-7416" name="phospholipid remodeling (phosphatidylcholine, yeast)"/>
            <pathway-xref db="MetaCyc" id="PWY-7253" name="apigeninidin 5-O-glucoside biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5971" name="palmitate biosynthesis II (type II fatty acid synthase)"/>
            <pathway-xref db="Reactome" id="R-MMU-77289" name="Mitochondrial Fatty Acid Beta-Oxidation"/>
            <pathway-xref db="Reactome" id="R-MMU-8964026" name="Chylomicron clearance"/>
            <pathway-xref db="MetaCyc" id="PWY-6558" name="heparan sulfate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5976" name="dhurrin degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-5399" name="betacyanin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6084" name="3,5-dichlorocatechol degradation"/>
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            <pathway-xref db="MetaCyc" id="PWY-5490" name="paraoxon degradation"/>
            <pathway-xref db="Reactome" id="R-RNO-8964026" name="Chylomicron clearance"/>
            <pathway-xref db="Reactome" id="R-MMU-1483191" name="Synthesis of PC"/>
            <pathway-xref db="Reactome" id="R-RNO-426048" name="Arachidonate production from DAG"/>
            <pathway-xref db="MetaCyc" id="PWY-7452" name="cyanidin dimalonylglucoside biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7157" name="eupatolitin 3-O-glucoside biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6955" name="lincomycin A biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5707" name="propanethial S-oxide biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9029558" name="NR1H2 &amp; NR1H3 regulate gene expression linked to lipogenesis"/>
            <pathway-xref db="Reactome" id="R-MMU-199220" name="Vitamin B5 (pantothenate) metabolism"/>
            <pathway-xref db="MetaCyc" id="PWY-8032" name="chloramphenicol biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5651" name="L-tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde"/>
            <pathway-xref db="MetaCyc" id="PWY-7496" name="linuron degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-8038" name="naphthomycin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7055" name="daphnetin modification"/>
            <pathway-xref db="MetaCyc" id="PWY-7737" name="thiocoraline biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5759" name="saponin biosynthesis III"/>
            <pathway-xref db="MetaCyc" id="PWY-7458" name="violdelphin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-2132295" name="MHC class II antigen presentation"/>
            <pathway-xref db="MetaCyc" id="PWY-7672" name="fusaric acid biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7448" name="galloylated catechin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7529" name="CMP-N-acetyl-7-O-acetylneuraminate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-163765" name="ChREBP activates metabolic gene expression"/>
            <pathway-xref db="MetaCyc" id="PWY-7667" name="apicidin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6996" name="daidzin and daidzein degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-8964026" name="Chylomicron clearance"/>
            <pathway-xref db="Reactome" id="R-RNO-156588" name="Glucuronidation"/>
            <pathway-xref db="MetaCyc" id="PWY-7543" name="5-N-acetylardeemin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7109" name="megalomicin A biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6710" name="poly-hydroxy fatty acids biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7734" name="quinoxaline-2-carboxylate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DRE-426048" name="Arachidonate production from DAG"/>
            <pathway-xref db="MetaCyc" id="PWY-7430" name="indole degradation to anthranil and anthranilate"/>
            <pathway-xref db="MetaCyc" id="PWY-5797" name="indole-3-acetate inactivation VI"/>
            <pathway-xref db="MetaCyc" id="PWY-7794" name="polyethylene terephthalate degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-8029" name="limonene degradation IV (anaerobic)"/>
            <pathway-xref db="MetaCyc" id="PWY-7093" name="vicianin bioactivation"/>
            <pathway-xref db="MetaCyc" id="PWY-7285" name="methylwyosine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7842" name="UDP-yelosamine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5784" name="indole-3-acetate inactivation VIII"/>
            <pathway-xref db="MetaCyc" id="PWY-5679" name="clavulanate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5782" name="2-keto-L-gulonate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DDI-211945" name="Phase I - Functionalization of compounds"/>
            <pathway-xref db="Reactome" id="R-HSA-2132295" name="MHC class II antigen presentation"/>
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            <pathway-xref db="MetaCyc" id="PWY-6178" name="2,4,6-trichlorophenol degradation"/>
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            <pathway-xref db="Reactome" id="R-MMU-162791" name="Attachment of GPI anchor to uPAR"/>
            <pathway-xref db="MetaCyc" id="PWY-7987" name="vanchrobactin biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-5629" name="isopenicillin N biosynthesis"/>
            <pathway-xref db="Reactome" id="R-BTA-8964038" name="LDL clearance"/>
            <pathway-xref db="MetaCyc" id="PWY-8075" name="(Kdo)2-lipid A biosynthesis (P. putida)"/>
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            <pathway-xref db="Reactome" id="R-MMU-159418" name="Recycling of bile acids and salts"/>
            <pathway-xref db="MetaCyc" id="PWY-5098" name="chlorophyll a degradation I"/>
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            <pathway-xref db="Reactome" id="R-HSA-6803205" name="TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain"/>
            <pathway-xref db="MetaCyc" id="PWY-8247" name="(Kdo)2-lipid A biosynthesis (P. gingivalis)"/>
            <pathway-xref db="Reactome" id="R-HSA-2022377" name="Metabolism of Angiotensinogen to Angiotensins"/>
            <pathway-xref db="MetaCyc" id="PWY-321" name="cutin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-8963889" name="Assembly of active LPL and LIPC lipase complexes"/>
            <pathway-xref db="MetaCyc" id="PWY-6289" name="petrobactin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-1961" name="indole-3-acetate inactivation I"/>
            <pathway-xref db="MetaCyc" id="PWY-6821" name="kappa-carrageenan degradation"/>
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            <pathway-xref db="Reactome" id="R-HSA-2142670" name="Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)"/>
            <pathway-xref db="MetaCyc" id="PWY-7547" name="prodigiosin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-2881" name="cytokinins 7-N-glucoside biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-1061" name="homogalacturonan biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-4202" name="arsenic detoxification (mammals)"/>
            <pathway-xref db="Reactome" id="R-XTR-211945" name="Phase I - Functionalization of compounds"/>
            <pathway-xref db="MetaCyc" id="PWY-7660" name="tryptoquialanine biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-8052" name="2-arachidonoylglycerol biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5339" name="chalcone 2'-O-glucoside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-8964038" name="LDL clearance"/>
            <pathway-xref db="Reactome" id="R-MMU-426048" name="Arachidonate production from DAG"/>
            <pathway-xref db="MetaCyc" id="PWY-7256" name="cyanidin diglucoside biosynthesis (acyl-glucose dependent)"/>
            <pathway-xref db="MetaCyc" id="PWY-7265" name="lampranthin biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-7331" name="UDP-N-acetyl-beta-L-quinovosamine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7134" name="rutin degradation (plants)"/>
            <pathway-xref db="MetaCyc" id="PWY-7752" name="gadusol biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5972" name="stearate biosynthesis I (animals)"/>
            <pathway-xref db="MetaCyc" id="PWY-7018" name="paromomycin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8104" name="yangonin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7419" name="FR-900098 and FR-33289 antibiotics biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8175" name="even iso-branched-chain fatty acid biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7818" name="type IV lipoteichoic acid biosynthesis (S. pneumoniae)"/>
            <pathway-xref db="MetaCyc" id="PWY-6385" name="peptidoglycan biosynthesis III (mycobacteria)"/>
            <pathway-xref db="MetaCyc" id="PWY-7624" name="nystatin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-GGA-9648002" name="RAS processing"/>
            <pathway-xref db="MetaCyc" id="PWY-7044" name="5-nitroanthranilate degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-6397" name="mycolyl-arabinogalactan-peptidoglycan complex biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-192456" name="Digestion of dietary lipid"/>
            <pathway-xref db="MetaCyc" id="PWY-5642" name="2,4-dinitrotoluene degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-6693" name="D-galactose degradation IV"/>
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            <pathway-xref db="Reactome" id="R-DDI-1483191" name="Synthesis of PC"/>
            <pathway-xref db="MetaCyc" id="PWY-7950" name="diadinoxanthin and fucoxanthin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6297" name="tuberonate glucoside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-390247" name="Beta-oxidation of very long chain fatty acids"/>
            <pathway-xref db="MetaCyc" id="PWY-7420" name="monoacylglycerol metabolism (yeast)"/>
            <pathway-xref db="MetaCyc" id="PWY-7930" name="pyoluteorin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7011" name="2-isopropylphenol degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-6842" name="glutathione-mediated detoxification II"/>
            <pathway-xref db="MetaCyc" id="PWY-8212" name="Escherichia coli serotype O:8 O antigen biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5161" name="6'-deoxychalcone metabolism"/>
            <pathway-xref db="Reactome" id="R-MMU-381771" name="Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)"/>
            <pathway-xref db="MetaCyc" id="PWY-7569" name="arginomycin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5101" name="L-isoleucine biosynthesis II"/>
            <pathway-xref db="MetaCyc" id="PWY-7498" name="phenylpropanoids methylation (ice plant)"/>
            <pathway-xref db="Reactome" id="R-HSA-3214847" name="HATs acetylate histones"/>
            <pathway-xref db="MetaCyc" id="PWY-7982" name="pinoresinol degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7983" name="pseudomonine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-75105" name="Fatty acyl-CoA biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5400" name="amaranthin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7998" name="menaquinol-4 biosynthesis II"/>
            <pathway-xref db="MetaCyc" id="PWY-8244" name="Escherichia coli serotype O:177 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SSC-9018682" name="Biosynthesis of maresins"/>
            <pathway-xref db="MetaCyc" id="PWY-5489" name="methyl parathion degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-6926" name="pyrethrin I biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7869" name="cis-alkene biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6690" name="cinnamate and 3-hydroxycinnamate degradation to 2-hydroxypentadienoate"/>
            <pathway-xref db="MetaCyc" id="PWY-5729" name="vestitol and sativan biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SPO-196757" name="Metabolism of folate and pterines"/>
            <pathway-xref db="MetaCyc" id="PWY-8232" name="Shigella boydii serotype 6 O antigen biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-6322" name="phosphinothricin tripeptide biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6637" name="sulfolactate degradation II"/>
            <pathway-xref db="Reactome" id="R-HSA-8964038" name="LDL clearance"/>
            <pathway-xref db="MetaCyc" id="PWY-5710" name="capsaicin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7568" name="L-galactose degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-5793" name="maysin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-69273" name="Cyclin A/B1/B2 associated events during G2/M transition"/>
            <pathway-xref db="MetaCyc" id="PWY-7717" name="3-hydroxy-4-methyl-anthranilate biosynthesis I"/>
            <pathway-xref db="MetaCyc" id="PWY-5437" name="L-threonine degradation I"/>
            <pathway-xref db="Reactome" id="R-MMU-8963889" name="Assembly of active LPL and LIPC lipase complexes"/>
            <pathway-xref db="MetaCyc" id="PWY-7474" name="avenacin A-2 biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-6704" name="L-ascorbate degradation IV"/>
            <pathway-xref db="MetaCyc" id="PWY-6401" name="hispidol and hispidol 4'-O-beta-D-glucoside biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5379" name="B series fagopyritols biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7655" name="dechlorogriseofulvin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7607" name="meleagrin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8139" name="CDP-6-deoxy-D-gulose biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6585" name="2-methylketone biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-3841" name="folate transformations II (plants)"/>
            <pathway-xref db="MetaCyc" id="PWY-7533" name="gliotoxin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7037" name="protein O-glycosylation (Neisseria)"/>
            <pathway-xref db="MetaCyc" id="PWY-2343" name="daidzein conjugates interconversion"/>
            <pathway-xref db="Reactome" id="R-MMU-192456" name="Digestion of dietary lipid"/>
            <pathway-xref db="Reactome" id="R-CEL-211945" name="Phase I - Functionalization of compounds"/>
            <pathway-xref db="Reactome" id="R-CFA-422085" name="Synthesis, secretion, and deacylation of Ghrelin"/>
            <pathway-xref db="MetaCyc" id="PWY-7421" name="narbomycin, pikromycin and novapikromycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SCE-192456" name="Digestion of dietary lipid"/>
            <pathway-xref db="MetaCyc" id="PWY-6336" name="protocatechuate degradation III (para-cleavage pathway)"/>
            <pathway-xref db="MetaCyc" id="PWY-7664" name="oleate biosynthesis IV (anaerobic)"/>
            <pathway-xref db="MetaCyc" id="PWY-7164" name="chlorophyll a degradation III"/>
            <pathway-xref db="Reactome" id="R-RNO-1482883" name="Acyl chain remodeling of DAG and TAG"/>
            <pathway-xref db="MetaCyc" id="PWY-7697" name="geranyl beta-primeveroside biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7172" name="flavonol acylglucoside biosynthesis III - quercetin derivatives"/>
            <pathway-xref db="MetaCyc" id="PWY-6314" name="plumbagin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7765" name="3-hydroxy-4-methyl-anthranilate biosynthesis II"/>
            <pathway-xref db="MetaCyc" id="PWY-6087" name="4-chlorocatechol degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7155" name="7-dehydroporiferasterol biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6032" name="digitoxigenin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7403" name="tetramethylpyrazine degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-8963901" name="Chylomicron remodeling"/>
            <pathway-xref db="MetaCyc" id="PWY-7473" name="avenacin A-1 biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7739" name="aucuparin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-156588" name="Glucuronidation"/>
            <pathway-xref db="MetaCyc" id="PWY-7716" name="penicillin G and penicillin V biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-8963901" name="Chylomicron remodeling"/>
            <pathway-xref db="MetaCyc" id="PWY-6733" name="sporopollenin precursors biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5059" name="pinobanksin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7192" name="quercetin diglycoside biosynthesis (pollen-specific)"/>
            <pathway-xref db="MetaCyc" id="PWY-7138" name="noscapine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7771" name="butachlor degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7885" name="phosphatidylinositol mannoside biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7647" name="ulvan degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-6190" name="2,4-dichlorotoluene degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7977" name="L-methionine biosynthesis IV"/>
            <pathway-xref db="MetaCyc" id="PWY-7475" name="des-methyl avenacin A-1 biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6320" name="phaselate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6623" name="salicylate glucosides biosynthesis II"/>
            <pathway-xref db="MetaCyc" id="PWY-6835" name="6-gingerol biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6863" name="pyruvate fermentation to hexanol (engineered)"/>
            <pathway-xref db="MetaCyc" id="PWY-6407" name="yersiniabactin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-1483166" name="Synthesis of PA"/>
            <pathway-xref db="Reactome" id="R-RNO-156590" name="Glutathione conjugation"/>
            <pathway-xref db="MetaCyc" id="PWY-6857" name="retinol biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-1121" name="suberin monomers biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8042" name="acylceramide biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-981" name="salicylate biosynthesis II"/>
            <pathway-xref db="MetaCyc" id="PWY-6855" name="chitin degradation I (archaea)"/>
            <pathway-xref db="MetaCyc" id="PWY-2021" name="indole-3-acetate inactivation IV"/>
            <pathway-xref db="Reactome" id="R-HSA-140837" name="Intrinsic Pathway of Fibrin Clot Formation"/>
            <pathway-xref db="Reactome" id="R-XTR-426048" name="Arachidonate production from DAG"/>
            <pathway-xref db="MetaCyc" id="PWY-5975" name="furaneol and mesifurane biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7045" name="mithramycin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8122" name="mycofactocin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6917" name="vernolate biosynthesis III"/>
            <pathway-xref db="MetaCyc" id="PWY-5286" name="anthocyanidin sophoroside metabolism"/>
            <pathway-xref db="MetaCyc" id="PWY-7415" name="tylosin biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-7461" name="hydroxycinnamate sugar acid ester biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-6312" name="barbaloin biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-761" name="rhizobactin 1021 biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-735" name="jasmonic acid biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-SCE-1483191" name="Synthesis of PC"/>
            <pathway-xref db="MetaCyc" id="PWY-4801" name="aloesone biosynthesis I"/>
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            <pathway-xref db="MetaCyc" id="PWY-6574" name="achromobactin biosynthesis"/>
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            <pathway-xref db="MetaCyc" id="PWY-7563" name="bassianin and desmethylbassianin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-3542" name="choline biosynthesis II"/>
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            <pathway-xref db="MetaCyc" id="PWY-6984" name="lipoate salvage II"/>
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            <pathway-xref db="MetaCyc" id="PWY-7740" name="beta-D-mannosyl phosphomycoketide biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7589" name="palmitoleate biosynthesis III (cyanobacteria)"/>
            <pathway-xref db="MetaCyc" id="PWY-8233" name="Escherichia coli serotype O:169 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9696273" name="RND1 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-6550" name="carbazole degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7592" name="arachidonate biosynthesis III (6-desaturase, mammals)"/>
            <pathway-xref db="MetaCyc" id="PWY-8217" name="Escherichia coli serotype O:55/Salmonella enterica serotype O:50 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-1482839" name="Acyl chain remodelling of PE"/>
            <pathway-xref db="MetaCyc" id="PWY-6738" name="pinitol biosynthesis I"/>
            <pathway-xref db="MetaCyc" id="PWY-5996" name="oleate biosynthesis II (animals and fungi)"/>
            <pathway-xref db="MetaCyc" id="PWY-8297" name="6-diazo-5-oxo-L-norleucine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6786" name="detoxification of reactive carbonyls in chloroplasts"/>
            <pathway-xref db="MetaCyc" id="PWY-8206" name="Salmonella enterica serotype O:18 O antigen biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-2601" name="isethionate degradation"/>
            <pathway-xref db="Reactome" id="R-SSC-2142670" name="Synthesis of epoxy (EET) and dihydroxyeicosatrienoic acids (DHET)"/>
            <pathway-xref db="Reactome" id="R-RNO-400511" name="Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP)"/>
            <pathway-xref db="Reactome" id="R-HSA-1482839" name="Acyl chain remodelling of PE"/>
            <pathway-xref db="MetaCyc" id="PWY-7385" name="1,3-propanediol biosynthesis (engineered)"/>
            <pathway-xref db="MetaCyc" id="PWY-5366" name="palmitoleate biosynthesis II (plants and bacteria)"/>
            <pathway-xref db="MetaCyc" id="PWY-3162" name="L-tryptophan degradation V (side chain pathway)"/>
            <pathway-xref db="Reactome" id="R-HSA-426048" name="Arachidonate production from DAG"/>
            <pathway-xref db="MetaCyc" id="PWY-6974" name="dTDP-beta-L-olivose biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5837" name="2-carboxy-1,4-naphthoquinol biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6762" name="salicylate glucosides biosynthesis IV"/>
            <pathway-xref db="MetaCyc" id="PWY-7337" name="10-cis-heptadecenoyl-CoA degradation (yeast)"/>
            <pathway-xref db="MetaCyc" id="PWY-8152" name="androstenedione degradation II (anaerobic)"/>
            <pathway-xref db="MetaCyc" id="PWY-5765" name="1,3,5-trimethoxybenzene biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5048" name="rosmarinic acid biosynthesis I"/>
            <pathway-xref db="MetaCyc" id="PWY-361" name="phenylpropanoid biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7897" name="flavonoid di-C-glucosylation"/>
            <pathway-xref db="MetaCyc" id="PWY-7650" name="echinocandin B biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-6809371" name="Formation of the cornified envelope"/>
            <pathway-xref db="Reactome" id="R-BTA-1483115" name="Hydrolysis of LPC"/>
            <pathway-xref db="MetaCyc" id="PWY-5319" name="coumarin metabolism (to melilotic acid)"/>
            <pathway-xref db="MetaCyc" id="PWY-8055" name="palmitoyl ethanolamide biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-77289" name="Mitochondrial Fatty Acid Beta-Oxidation"/>
            <pathway-xref db="Reactome" id="R-DDI-203615" name="eNOS activation"/>
            <pathway-xref db="MetaCyc" id="PWY-8031" name="epiberberine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7787" name="L-threitol degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-72764" name="Eukaryotic Translation Termination"/>
            <pathway-xref db="Reactome" id="R-DME-75105" name="Fatty acyl-CoA biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7570" name="blasticidin S biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6442" name="spermidine hydroxycinnamic acid conjugates biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7009" name="2,2'-dihydroxybiphenyl degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-5984" name="rifamycin B biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6061" name="bile acid biosynthesis, neutral pathway"/>
            <pathway-xref db="MetaCyc" id="PWY-8173" name="anteiso-branched-chain fatty acid biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7450" name="anthocyanidin modification (Arabidopsis)"/>
            <pathway-xref db="MetaCyc" id="PWY-5926" name="afrormosin conjugates interconversion"/>
            <pathway-xref db="MetaCyc" id="PWY-8253" name="Escherichia coli serotype O:149/Shigella boydii serotype O1 O antigen biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7354" name="aclacinomycin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7145" name="genistin gentiobioside biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7517" name="brassicicene C biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7921" name="protein O-mannosylation I (yeast)"/>
            <pathway-xref db="Reactome" id="R-HSA-75105" name="Fatty acyl-CoA biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7006" name="4-amino-3-hydroxybenzoate degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7554" name="heme d1 biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-159418" name="Recycling of bile acids and salts"/>
            <pathway-xref db="MetaCyc" id="PWY-7007" name="methyl ketone biosynthesis (engineered)"/>
            <pathway-xref db="MetaCyc" id="PWY-7530" name="Escherichia coli serotype O:104 O antigen biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8205" name="Escherichia coli serotype O:77/Salmonella enterica serotype O:6,14 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-1483191" name="Synthesis of PC"/>
            <pathway-xref db="MetaCyc" id="PWY-7491" name="podophyllotoxin glucosides metabolism"/>
            <pathway-xref db="MetaCyc" id="PWY-5268" name="salvianin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-4085001" name="Sialic acid metabolism"/>
            <pathway-xref db="MetaCyc" id="PWY-7463" name="N-methylanthraniloyl-beta-D-glucopyranose biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-721" name="3-methylquinoline degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7166" name="kaempferide triglycoside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-975634" name="Retinoid metabolism and transport"/>
            <pathway-xref db="MetaCyc" id="PWY-5497" name="purine nucleobases degradation II (anaerobic)"/>
            <pathway-xref db="MetaCyc" id="PWY-7056" name="daphnin interconversion"/>
            <pathway-xref db="Reactome" id="R-RNO-9648002" name="RAS processing"/>
            <pathway-xref db="MetaCyc" id="PWY-6667" name="resveratrol degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-6673" name="caffeoylglucarate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-601" name="glucosinolate biosynthesis from tryptophan"/>
            <pathway-xref db="MetaCyc" id="PWY-6799" name="fatty acid biosynthesis initiation (plant mitochondria)"/>
            <pathway-xref db="MetaCyc" id="PWY-7658" name="protein N-glycosylation (Methanococcus voltae)"/>
            <pathway-xref db="MetaCyc" id="PWY-7656" name="Spodoptera littoralis pheromone biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6453" name="stigma estolide biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5271" name="abscisic acid degradation to phaseic acid"/>
            <pathway-xref db="MetaCyc" id="PWY-7130" name="L-glucose degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7159" name="3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent)"/>
            <pathway-xref db="MetaCyc" id="PWY-8234" name="Escherichia coli serotype O:183/Shigella boydii serotype O:10 O antigen biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5367" name="petroselinate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7692" name="bikaverin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-6809371" name="Formation of the cornified envelope"/>
            <pathway-xref db="MetaCyc" id="PWY-7811" name="6-methylpretetramide biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-2541" name="phytosterol biosynthesis (plants)"/>
            <pathway-xref db="MetaCyc" id="PWY-6920" name="6-gingerol analog biosynthesis (engineered)"/>
            <pathway-xref db="Reactome" id="R-SCE-1483115" name="Hydrolysis of LPC"/>
            <pathway-xref db="MetaCyc" id="PWY-6093" name="4,5-dichlorocatechol degradation"/>
            <pathway-xref db="Reactome" id="R-RNO-162791" name="Attachment of GPI anchor to uPAR"/>
            <pathway-xref db="MetaCyc" id="PWY-7742" name="phenolphthiocerol biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CFA-1483115" name="Hydrolysis of LPC"/>
            <pathway-xref db="MetaCyc" id="PWY-7602" name="icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)"/>
            <pathway-xref db="MetaCyc" id="PWY-7706" name="dapdiamides biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7988" name="baumannoferrin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8172" name="10-methylstearate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7318" name="dTDP-3-acetamido-3,6-dideoxy-alpha-D-glucose biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-4085001" name="Sialic acid metabolism"/>
            <pathway-xref db="MetaCyc" id="PWY-7986" name="anguibactin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-6794361" name="Neurexins and neuroligins"/>
            <pathway-xref db="MetaCyc" id="PWY-6906" name="chitin derivatives degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7687" name="stipitatate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6927" name="chlorophyll a degradation II"/>
            <pathway-xref db="MetaCyc" id="PWY-6379" name="alcaligin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7074" name="phenylethanol glycoconjugate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-9696273" name="RND1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-HSA-373760" name="L1CAM interactions"/>
            <pathway-xref db="Reactome" id="R-MMU-422085" name="Synthesis, secretion, and deacylation of Ghrelin"/>
            <pathway-xref db="MetaCyc" id="PWY-1981" name="indole-3-acetate inactivation III"/>
            <pathway-xref db="MetaCyc" id="PWY-5867" name="t-anethole biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7042" name="the visual cycle (insects)"/>
            <pathway-xref db="MetaCyc" id="PWY-7730" name="T-2 toxin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-156590" name="Glutathione conjugation"/>
            <pathway-xref db="Reactome" id="R-RNO-1483115" name="Hydrolysis of LPC"/>
            <pathway-xref db="MetaCyc" id="PWY-4161" name="superpathway of benzoxazinoid glucosides biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8204" name="Salmonella enterica serotype O:54 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DDI-69273" name="Cyclin A/B1/B2 associated events during G2/M transition"/>
            <pathway-xref db="MetaCyc" id="PWY-7799" name="Arg/N-end rule pathway (eukaryotic)"/>
            <pathway-xref db="Reactome" id="R-RNO-3214847" name="HATs acetylate histones"/>
            <pathway-xref db="MetaCyc" id="PWY-7407" name="aurachin A, B, C and D biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6930" name="phenolic malonylglucosides biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6627" name="salinosporamide A biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7213" name="wogonin metabolism"/>
            <pathway-xref db="MetaCyc" id="PWY-6193" name="3-chlorocatechol degradation II (ortho)"/>
            <pathway-xref db="MetaCyc" id="PWY-6309" name="L-tryptophan degradation XI (mammalian, via kynurenine)"/>
            <pathway-xref db="Reactome" id="R-DRE-1483166" name="Synthesis of PA"/>
            <pathway-xref db="Reactome" id="R-MMU-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="MetaCyc" id="PWY-5519" name="D-arabinose degradation III"/>
            <pathway-xref db="Reactome" id="R-CEL-6798695" name="Neutrophil degranulation"/>
            <pathway-xref db="MetaCyc" id="PWY-6310" name="aloesone biosynthesis II"/>
            <pathway-xref db="MetaCyc" id="PWY-7405" name="aurachin RE biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5818" name="validamycin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7191" name="kaempferol diglycoside biosynthesis (pollen-specific)"/>
            <pathway-xref db="MetaCyc" id="PWY-5989" name="stearate biosynthesis II (bacteria and plants)"/>
            <pathway-xref db="MetaCyc" id="PWY-6657" name="polyhydroxydecanoate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6024" name="isovitexin glycosides biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-2022377" name="Metabolism of Angiotensinogen to Angiotensins"/>
            <pathway-xref db="MetaCyc" id="PWY-5407" name="9-lipoxygenase and 9-allene oxide synthase pathway"/>
            <pathway-xref db="MetaCyc" id="PWY-8155" name="testosterone degradation (anaerobic)"/>
            <pathway-xref db="MetaCyc" id="PWY-7072" name="hopanoid biosynthesis (bacteria)"/>
            <pathway-xref db="Reactome" id="R-DDI-112311" name="Neurotransmitter clearance"/>
            <pathway-xref db="MetaCyc" id="PWY-8242" name="Escherichia coli serotype O:51/Salmonella enterica serotype O:57 O antigen biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7815" name="poly(ribitol phosphate) wall teichoic acid biosynthesis I (B. subtilis)"/>
            <pathway-xref db="MetaCyc" id="PWY-5666" name="alpha-solanine/alpha-chaconine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-842" name="starch degradation I"/>
            <pathway-xref db="MetaCyc" id="PWY-7274" name="D-cycloserine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5794" name="malonate degradation I (biotin-independent)"/>
            <pathway-xref db="MetaCyc" id="PWY-7870" name="L-cysteine biosynthesis VII (from S-sulfo-L-cysteine)"/>
            <pathway-xref db="MetaCyc" id="PWY-6339" name="syringate degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-2901" name="cytokinins 9-N-glucoside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SPO-1482839" name="Acyl chain remodelling of PE"/>
            <pathway-xref db="MetaCyc" id="PWY-7333" name="UDP-N-acetyl-alpha-D-fucosamine biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6102" name="5-chloro-3-methyl-catechol degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-6053" name="dimethylsulfoniopropanoate biosynthesis III (algae and phytoplankton)"/>
            <pathway-xref db="MetaCyc" id="PWY-7825" name="juglone degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7838" name="globo-series glycosphingolipids biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7076" name="3,5-dimethoxytoluene biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7633" name="calycosin 7-O-glucoside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SCE-1483166" name="Synthesis of PA"/>
            <pathway-xref db="MetaCyc" id="PWY-7129" name="quercetin glucoside biosynthesis (Allium)"/>
            <pathway-xref db="Reactome" id="R-MMU-9018682" name="Biosynthesis of maresins"/>
            <pathway-xref db="Reactome" id="R-RNO-199220" name="Vitamin B5 (pantothenate) metabolism"/>
            <pathway-xref db="MetaCyc" id="PWY-7027" name="hentriaconta-3,6,9,12,15,19,22,25,28-nonaene biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7712" name="deoxynivalenol biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7339" name="10-trans-heptadecenoyl-CoA degradation (MFE-dependent, yeast)"/>
            <pathway-xref db="MetaCyc" id="PWY-5301" name="ajmaline and sarpagine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SPO-204005" name="COPII-mediated vesicle transport"/>
            <pathway-xref db="Reactome" id="R-HSA-156588" name="Glucuronidation"/>
            <pathway-xref db="MetaCyc" id="PWY-7984" name="acinetobactin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5321" name="quercetin glycoside biosynthesis (Arabidopsis)"/>
            <pathway-xref db="MetaCyc" id="PWY-8269" name="methylarsonous acid detoxification III"/>
            <pathway-xref db="Reactome" id="R-HSA-203615" name="eNOS activation"/>
            <pathway-xref db="MetaCyc" id="PWY-8235" name="Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-6794361" name="Neurexins and neuroligins"/>
          </entry>
          <signature-library-release library="SUPERFAMILY" version="1.75"/>
        </signature>
        <model-ac>0053925</model-ac>
        <locations>
          <superfamilyhmmer3-location hmm-length="218" start="319" end="456">
            <location-fragments>
              <superfamilyhmmer3-location-fragment start="319" end="456" dc-status="CONTINUOUS"/>
            </location-fragments>
          </superfamilyhmmer3-location>
        </locations>
      </superfamilyhmmer3-match>
    </matches>
  </protein>
  <protein>
    <sequence md5="be75dc7123e50af1439584448a912cec">MAGPMQAVNISQGSTVSHVICRICHEGDRLIPLISPCACSGSVGTIHQVCLEKWLSTVNKDDCELCGRKFLVHKNPKSITRWLLRSPFSDAHRNIIGDTICFFILTPMSLISAYLCVLGAVNHSDVVGGCASVVLLSLALFLVLVYTAWVIVTIRFQIKWILTWRKENQTVQLTQVDQADIV</sequence>
    <xref id="TCALIF_00377-PA" name="TCALIF_00377-PA protein Name:&quot;Similar to march3 E3 ubiquitin-protein ligase MARCH3 (Xenopus laevis)&quot; AED:0.04 eAED:0.04 QI:244|1|1|1|1|1|3|139|182"/>
    <matches>
      <hmmer2-match evalue="1.3E-17" score="74.6">
        <signature ac="SM00744" name="ringv_2">
          <entry ac="IPR011016" desc="Zinc finger, RING-CH-type" name="Znf_RING-CH" type="DOMAIN">
            <go-xref category="MOLECULAR_FUNCTION" db="GO" id="GO:0008270" name="zinc ion binding"/>
            <pathway-xref db="Reactome" id="R-HSA-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-SCE-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-901032" name="ER Quality Control Compartment (ERQC)"/>
            <pathway-xref db="Reactome" id="R-XTR-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7511" name="protein ubiquitination"/>
          </entry>
          <signature-library-release library="SMART" version="7.1"/>
        </signature>
        <model-ac>SM00744</model-ac>
        <locations>
          <hmmer2-location score="74.6" evalue="1.3E-17" hmm-start="1" hmm-end="55" hmm-length="55" hmm-bounds="COMPLETE" start="20" end="67">
            <location-fragments>
              <hmmer2-location-fragment start="20" end="67" dc-status="CONTINUOUS"/>
            </location-fragments>
          </hmmer2-location>
        </locations>
      </hmmer2-match>
      <hmmer3-match evalue="2.6E-14" score="53.0">
        <signature ac="PF12906" desc="RING-variant domain" name="RINGv">
          <entry ac="IPR011016" desc="Zinc finger, RING-CH-type" name="Znf_RING-CH" type="DOMAIN">
            <go-xref category="MOLECULAR_FUNCTION" db="GO" id="GO:0008270" name="zinc ion binding"/>
            <pathway-xref db="Reactome" id="R-HSA-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-SCE-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-901032" name="ER Quality Control Compartment (ERQC)"/>
            <pathway-xref db="Reactome" id="R-XTR-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7511" name="protein ubiquitination"/>
          </entry>
          <signature-library-release library="PFAM" version="34.0"/>
        </signature>
        <model-ac>PF12906</model-ac>
        <locations>
          <hmmer3-location env-end="66" env-start="21" post-processed="true" score="51.7" evalue="7.0E-14" hmm-start="1" hmm-end="48" hmm-length="48" hmm-bounds="COMPLETE" start="21" end="66">
            <location-fragments>
              <hmmer3-location-fragment start="21" end="66" dc-status="CONTINUOUS"/>
            </location-fragments>
          </hmmer3-location>
        </locations>
      </hmmer3-match>
      <hmmer3-match evalue="3.4E-19" score="70.2">
        <signature ac="G3DSA:3.30.40.10" name="Zinc/RING finger domain, C3HC4 (zinc finger)">
          <entry ac="IPR013083" desc="Zinc finger, RING/FYVE/PHD-type" name="Znf_RING/FYVE/PHD" type="HOMOLOGOUS_SUPERFAMILY">
            <pathway-xref db="MetaCyc" id="PWY-8238" name="24-epi-campesterol, fucosterol, and clionasterol biosynthesis (diatoms)"/>
            <pathway-xref db="Reactome" id="R-HSA-113418" name="Formation of the Early Elongation Complex"/>
            <pathway-xref db="MetaCyc" id="PWY-7325" name="salvigenin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-5689880" name="Ub-specific processing proteases"/>
            <pathway-xref db="Reactome" id="R-HSA-9663199" name="Defective DNA double strand break response due to BRCA1 loss of function"/>
            <pathway-xref db="Reactome" id="R-SCE-3214842" name="HDMs demethylate histones"/>
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            <pathway-xref db="MetaCyc" id="PWY-7487" name="(+)-secoisolariciresinol diglucoside biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-HSA-6783310" name="Fanconi Anemia Pathway"/>
            <pathway-xref db="Reactome" id="R-SPO-77075" name="RNA Pol II CTD phosphorylation and interaction with CE"/>
            <pathway-xref db="MetaCyc" id="PWY-7168" name="flavonol acylglucoside biosynthesis I - kaempferol derivatives"/>
            <pathway-xref db="Reactome" id="R-RNO-73762" name="RNA Polymerase I Transcription Initiation"/>
            <pathway-xref db="MetaCyc" id="PWY-7623" name="astaxanthin dirhamnoside biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5822" name="trichloroethene degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-2559580" name="Oxidative Stress Induced Senescence"/>
            <pathway-xref db="MetaCyc" id="PWY-5307" name="gentiodelphin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8000" name="vitamin K degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-2902" name="cytokinin-O-glucosides biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-8036" name="chaxamycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-937041" name="IKK complex recruitment mediated by RIP1"/>
            <pathway-xref db="Reactome" id="R-DRE-975871" name="MyD88 cascade initiated on plasma membrane"/>
            <pathway-xref db="MetaCyc" id="PWY-7743" name="dimycocerosyl triglycosyl phenolphthiocerol biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-167246" name="Tat-mediated elongation of the HIV-1 transcript"/>
            <pathway-xref db="MetaCyc" id="PWY-8237" name="Escherichia coli serotype O:1B/Salmonella enterica serotype O:42 O antigen biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6409" name="pyoverdine I biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-3232118" name="SUMOylation of transcription factors"/>
            <pathway-xref db="Reactome" id="R-CEL-6781823" name="Formation of TC-NER Pre-Incision Complex"/>
            <pathway-xref db="MetaCyc" id="PWY-7160" name="polymethylated myricetin biosynthesis (tomato)"/>
            <pathway-xref db="Reactome" id="R-MMU-6804115" name="TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain"/>
            <pathway-xref db="MetaCyc" id="PWY-102" name="gibberellin inactivation I (2beta-hydroxylation)"/>
            <pathway-xref db="Reactome" id="R-MMU-5689901" name="Metalloprotease DUBs"/>
            <pathway-xref db="Reactome" id="R-CEL-181430" name="Norepinephrine Neurotransmitter Release Cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-6971" name="oleandomycin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DME-3899300" name="SUMOylation of transcription cofactors"/>
            <pathway-xref db="Reactome" id="R-HSA-201722" name="Formation of the beta-catenin:TCF transactivating complex"/>
            <pathway-xref db="Reactome" id="R-DDI-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-9705462" name="Inactivation of CSF3 (G-CSF) signaling"/>
            <pathway-xref db="Reactome" id="R-MMU-2173789" name="TGF-beta receptor signaling activates SMADs"/>
            <pathway-xref db="MetaCyc" id="PWY-5036" name="gibberellin biosynthesis II (early C-3 hydroxylation)"/>
            <pathway-xref db="Reactome" id="R-HSA-5696400" name="Dual Incision in GG-NER"/>
            <pathway-xref db="Reactome" id="R-MMU-1632852" name="Macroautophagy"/>
            <pathway-xref db="Reactome" id="R-MMU-3108214" name="SUMOylation of DNA damage response and repair proteins"/>
            <pathway-xref db="Reactome" id="R-MMU-429947" name="Deadenylation of mRNA"/>
            <pathway-xref db="Reactome" id="R-GGA-8953750" name="Transcriptional Regulation by E2F6"/>
            <pathway-xref db="MetaCyc" id="PWY-5665" name="vanillin biosynthesis I"/>
            <pathway-xref db="Reactome" id="R-HSA-9013695" name="NOTCH4 Intracellular Domain Regulates Transcription"/>
            <pathway-xref db="Reactome" id="R-RNO-8943724" name="Regulation of PTEN gene transcription"/>
            <pathway-xref db="Reactome" id="R-BTA-205043" name="NRIF signals cell death from the nucleus"/>
            <pathway-xref db="Reactome" id="R-SPO-8866654" name="E3 ubiquitin ligases ubiquitinate target proteins"/>
            <pathway-xref db="Reactome" id="R-RNO-201722" name="Formation of the beta-catenin:TCF transactivating complex"/>
            <pathway-xref db="Reactome" id="R-RNO-112382" name="Formation of RNA Pol II elongation complex"/>
            <pathway-xref db="Reactome" id="R-MMU-73772" name="RNA Polymerase I Promoter Escape"/>
            <pathway-xref db="Reactome" id="R-DDI-176407" name="Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase"/>
            <pathway-xref db="Reactome" id="R-SCE-73772" name="RNA Polymerase I Promoter Escape"/>
            <pathway-xref db="Reactome" id="R-HSA-168927" name="TICAM1, RIP1-mediated IKK complex recruitment"/>
            <pathway-xref db="Reactome" id="R-DME-6782135" name="Dual incision in TC-NER"/>
            <pathway-xref db="Reactome" id="R-HSA-167162" name="RNA Polymerase II HIV Promoter Escape"/>
            <pathway-xref db="Reactome" id="R-CEL-76042" name="RNA Polymerase II Transcription Initiation And Promoter Clearance"/>
            <pathway-xref db="Reactome" id="R-SPO-9646399" name="Aggrephagy"/>
            <pathway-xref db="MetaCyc" id="PWY-6762" name="salicylate glucosides biosynthesis IV"/>
            <pathway-xref db="Reactome" id="R-MMU-69541" name="Stabilization of p53"/>
            <pathway-xref db="Reactome" id="R-HSA-5678895" name="Defective CFTR causes cystic fibrosis"/>
            <pathway-xref db="MetaCyc" id="PWY-5048" name="rosmarinic acid biosynthesis I"/>
            <pathway-xref db="MetaCyc" id="PWY-7897" name="flavonoid di-C-glucosylation"/>
            <pathway-xref db="Reactome" id="R-HSA-6804758" name="Regulation of TP53 Activity through Acetylation"/>
            <pathway-xref db="Reactome" id="R-RNO-202424" name="Downstream TCR signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-8055" name="palmitoyl ethanolamide biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-1660516" name="Synthesis of PIPs at the early endosome membrane"/>
            <pathway-xref db="Reactome" id="R-MMU-5693607" name="Processing of DNA double-strand break ends"/>
            <pathway-xref db="Reactome" id="R-HSA-9615017" name="FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes"/>
            <pathway-xref db="MetaCyc" id="PWY-7539" name="6-hydroxymethyl-dihydropterin diphosphate biosynthesis III (Chlamydia)"/>
            <pathway-xref db="Reactome" id="R-HSA-69416" name="Dimerization of procaspase-8"/>
            <pathway-xref db="MetaCyc" id="PWY-7450" name="anthocyanidin modification (Arabidopsis)"/>
            <pathway-xref db="Reactome" id="R-MMU-176409" name="APC/C:Cdc20 mediated degradation of mitotic proteins"/>
            <pathway-xref db="MetaCyc" id="PWY-5926" name="afrormosin conjugates interconversion"/>
            <pathway-xref db="MetaCyc" id="PWY-7354" name="aclacinomycin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7145" name="genistin gentiobioside biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7517" name="brassicicene C biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-975163" name="IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation"/>
            <pathway-xref db="MetaCyc" id="PWY-8205" name="Escherichia coli serotype O:77/Salmonella enterica serotype O:6,14 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-72163" name="mRNA Splicing - Major Pathway"/>
            <pathway-xref db="Reactome" id="R-HSA-3214842" name="HDMs demethylate histones"/>
            <pathway-xref db="MetaCyc" id="PWY-5268" name="salvianin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-9031628" name="NGF-stimulated transcription"/>
            <pathway-xref db="Reactome" id="R-MMU-8866907" name="Activation of the TFAP2 (AP-2) family of transcription factors"/>
            <pathway-xref db="Reactome" id="R-SCE-3214847" name="HATs acetylate histones"/>
            <pathway-xref db="Reactome" id="R-MMU-5357956" name="TNFR1-induced NFkappaB signaling pathway"/>
            <pathway-xref db="MetaCyc" id="PWY-601" name="glucosinolate biosynthesis from tryptophan"/>
            <pathway-xref db="Reactome" id="R-SSC-975163" name="IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation"/>
            <pathway-xref db="Reactome" id="R-DDI-8866654" name="E3 ubiquitin ligases ubiquitinate target proteins"/>
            <pathway-xref db="Reactome" id="R-DME-209360" name="Ubiquitination and proteolysis of phosphorylated CI"/>
            <pathway-xref db="MetaCyc" id="PWY-7656" name="Spodoptera littoralis pheromone biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6453" name="stigma estolide biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-1660499" name="Synthesis of PIPs at the plasma membrane"/>
            <pathway-xref db="MetaCyc" id="PWY-8234" name="Escherichia coli serotype O:183/Shigella boydii serotype O:10 O antigen biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7692" name="bikaverin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7811" name="6-methylpretetramide biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-3769402" name="Deactivation of the beta-catenin transactivating complex"/>
            <pathway-xref db="Reactome" id="R-DME-8854050" name="FBXL7 down-regulates AURKA during mitotic entry and in early mitosis"/>
            <pathway-xref db="MetaCyc" id="PWY-6367" name="D-myo-inositol-5-phosphate metabolism"/>
            <pathway-xref db="Reactome" id="R-SPO-674695" name="RNA Polymerase II Pre-transcription Events"/>
            <pathway-xref db="Reactome" id="R-GGA-4570464" name="SUMOylation of RNA binding proteins"/>
            <pathway-xref db="MetaCyc" id="PWY-6920" name="6-gingerol analog biosynthesis (engineered)"/>
            <pathway-xref db="MetaCyc" id="PWY-7602" name="icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes)"/>
            <pathway-xref db="Reactome" id="R-HSA-168638" name="NOD1/2 Signaling Pathway"/>
            <pathway-xref db="MetaCyc" id="PWY-7988" name="baumannoferrin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-8948747" name="Regulation of PTEN localization"/>
            <pathway-xref db="MetaCyc" id="PWY-8172" name="10-methylstearate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DRE-373752" name="Netrin-1 signaling"/>
            <pathway-xref db="Reactome" id="R-DRE-1169408" name="ISG15 antiviral mechanism"/>
            <pathway-xref db="MetaCyc" id="PWY-6147" name="6-hydroxymethyl-dihydropterin diphosphate biosynthesis I"/>
            <pathway-xref db="MetaCyc" id="PWY-7687" name="stipitatate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-2559582" name="Senescence-Associated Secretory Phenotype (SASP)"/>
            <pathway-xref db="MetaCyc" id="PWY-5757" name="fosfomycin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6379" name="alcaligin biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7074" name="phenylethanol glycoconjugate biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CFA-8943724" name="Regulation of PTEN gene transcription"/>
            <pathway-xref db="MetaCyc" id="PWY-7206" name="pyrimidine deoxyribonucleotides dephosphorylation"/>
            <pathway-xref db="Reactome" id="R-HSA-8951664" name="Neddylation"/>
            <pathway-xref db="Reactome" id="R-HSA-8951936" name="RUNX3 regulates p14-ARF"/>
            <pathway-xref db="Reactome" id="R-MMU-4570464" name="SUMOylation of RNA binding proteins"/>
            <pathway-xref db="Reactome" id="R-MMU-73776" name="RNA Polymerase II Promoter Escape"/>
            <pathway-xref db="Reactome" id="R-HSA-1295596" name="Spry regulation of FGF signaling"/>
            <pathway-xref db="MetaCyc" id="PWY-7730" name="T-2 toxin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-CEL-3214815" name="HDACs deacetylate histones"/>
            <pathway-xref db="MetaCyc" id="PWY-8204" name="Salmonella enterica serotype O:54 O antigen biosynthesis"/>
            <pathway-xref db="Reactome" id="R-RNO-201681" name="TCF dependent signaling in response to WNT"/>
            <pathway-xref db="Reactome" id="R-SPO-5696400" name="Dual Incision in GG-NER"/>
            <pathway-xref db="Reactome" id="R-MMU-3371378" name="Regulation by c-FLIP"/>
            <pathway-xref db="Reactome" id="R-HSA-2871837" name="FCERI mediated NF-kB activation"/>
            <pathway-xref db="Reactome" id="R-HSA-1266695" name="Interleukin-7 signaling"/>
            <pathway-xref db="Reactome" id="R-RNO-5668541" name="TNFR2 non-canonical NF-kB pathway"/>
            <pathway-xref db="Reactome" id="R-RNO-3214847" name="HATs acetylate histones"/>
            <pathway-xref db="Reactome" id="R-HSA-9646399" name="Aggrephagy"/>
            <pathway-xref db="MetaCyc" id="PWY-6930" name="phenolic malonylglucosides biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6627" name="salinosporamide A biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7213" name="wogonin metabolism"/>
            <pathway-xref db="Reactome" id="R-RNO-72086" name="mRNA Capping"/>
            <pathway-xref db="Reactome" id="R-HSA-8866654" name="E3 ubiquitin ligases ubiquitinate target proteins"/>
            <pathway-xref db="Reactome" id="R-SPO-8951664" name="Neddylation"/>
            <pathway-xref db="Reactome" id="R-MMU-9013422" name="RHOBTB1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-CEL-3108214" name="SUMOylation of DNA damage response and repair proteins"/>
            <pathway-xref db="Reactome" id="R-RNO-445355" name="Smooth Muscle Contraction"/>
            <pathway-xref db="MetaCyc" id="PWY-8080" name="kainate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7405" name="aurachin RE biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-176407" name="Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase"/>
            <pathway-xref db="Reactome" id="R-MMU-8866427" name="VLDLR internalisation and degradation"/>
            <pathway-xref db="Reactome" id="R-DME-110314" name="Recognition of DNA damage by PCNA-containing replication complex"/>
            <pathway-xref db="Reactome" id="R-HSA-427413" name="NoRC negatively regulates rRNA expression"/>
            <pathway-xref db="MetaCyc" id="PWY-6657" name="polyhydroxydecanoate biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-6024" name="isovitexin glycosides biosynthesis"/>
            <pathway-xref db="Reactome" id="R-DRE-2559585" name="Oncogene Induced Senescence"/>
            <pathway-xref db="MetaCyc" id="PWY-7072" name="hopanoid biosynthesis (bacteria)"/>
            <pathway-xref db="MetaCyc" id="PWY-8242" name="Escherichia coli serotype O:51/Salmonella enterica serotype O:57 O antigen biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-5666" name="alpha-solanine/alpha-chaconine biosynthesis"/>
            <pathway-xref db="Reactome" id="R-SPO-6804758" name="Regulation of TP53 Activity through Acetylation"/>
            <pathway-xref db="Reactome" id="R-SPO-3232118" name="SUMOylation of transcription factors"/>
            <pathway-xref db="Reactome" id="R-HSA-2894862" name="Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants"/>
            <pathway-xref db="Reactome" id="R-DME-5358346" name="Hedgehog ligand biogenesis"/>
            <pathway-xref db="Reactome" id="R-HSA-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-77075" name="RNA Pol II CTD phosphorylation and interaction with CE"/>
            <pathway-xref db="Reactome" id="R-CEL-73776" name="RNA Polymerase II Promoter Escape"/>
            <pathway-xref db="MetaCyc" id="PWY-7838" name="globo-series glycosphingolipids biosynthesis"/>
            <pathway-xref db="MetaCyc" id="PWY-7633" name="calycosin 7-O-glucoside biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-6803204" name="TP53 Regulates Transcription of Genes Involved in Cytochrome C Release"/>
            <pathway-xref db="Reactome" id="R-RNO-9706019" name="RHOBTB3 ATPase cycle"/>
            <pathway-xref db="Reactome" id="R-DRE-3214847" name="HATs acetylate histones"/>
            <pathway-xref db="Reactome" id="R-DME-8939243" name="RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known"/>
            <pathway-xref db="Reactome" id="R-RNO-73863" name="RNA Polymerase I Transcription Termination"/>
            <pathway-xref db="MetaCyc" id="PWY-7704" name="viridicatin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-MMU-937039" name="IRAK1 recruits IKK complex"/>
            <pathway-xref db="Reactome" id="R-MMU-3214815" name="HDACs deacetylate histones"/>
            <pathway-xref db="Reactome" id="R-RNO-8856825" name="Cargo recognition for clathrin-mediated endocytosis"/>
            <pathway-xref db="Reactome" id="R-MMU-8953750" name="Transcriptional Regulation by E2F6"/>
            <pathway-xref db="Reactome" id="R-MMU-9013420" name="RHOU GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-9013149" name="RAC1 GTPase cycle"/>
            <pathway-xref db="MetaCyc" id="PWY-7984" name="acinetobactin biosynthesis"/>
            <pathway-xref db="Reactome" id="R-HSA-5689896" name="Ovarian tumor domain proteases"/>
            <pathway-xref db="MetaCyc" id="PWY-5321" name="quercetin glycoside biosynthesis (Arabidopsis)"/>
            <pathway-xref db="MetaCyc" id="PWY-8235" name="Escherichia coli serotype O:21/Salmonella enterica serotype O:38 O antigen biosynthesis"/>
          </entry>
          <signature-library-release library="GENE3D" version="4.3.0"/>
        </signature>
        <model-ac>2d8sA00</model-ac>
        <locations>
          <hmmer3-location env-end="80" env-start="7" post-processed="true" score="69.3" evalue="6.5E-19" hmm-start="13" hmm-end="71" hmm-length="80" hmm-bounds="COMPLETE" start="7" end="80">
            <location-fragments>
              <hmmer3-location-fragment start="7" end="80" dc-status="CONTINUOUS"/>
            </location-fragments>
          </hmmer3-location>
        </locations>
      </hmmer3-match>
      <panther-match evalue="5.8E-44" familyName="E3 UBIQUITIN-PROTEIN LIGASE MARCH 2/3 FAMILY MEMBER" score="162.0">
        <signature ac="PTHR46065" name="E3 UBIQUITIN-PROTEIN LIGASE MARCH 2/3 FAMILY MEMBER">
          <signature-library-release library="PANTHER" version="15.0"/>
        </signature>
        <model-ac>PTHR46065</model-ac>
        <locations>
          <panther-location env-start="5" env-end="180" hmm-start="69" hmm-end="227" hmm-length="280" hmm-bounds="INCOMPLETE" start="17" end="175">
            <location-fragments>
              <panther-location-fragment start="17" end="175" dc-status="CONTINUOUS"/>
            </location-fragments>
          </panther-location>
        </locations>
      </panther-match>
      <profilescan-match>
        <signature ac="PS51292" desc="Zinc finger RING-CH-type profile." name="ZF_RING_CH">
          <entry ac="IPR011016" desc="Zinc finger, RING-CH-type" name="Znf_RING-CH" type="DOMAIN">
            <go-xref category="MOLECULAR_FUNCTION" db="GO" id="GO:0008270" name="zinc ion binding"/>
            <pathway-xref db="Reactome" id="R-HSA-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-SCE-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-MMU-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="Reactome" id="R-HSA-901032" name="ER Quality Control Compartment (ERQC)"/>
            <pathway-xref db="Reactome" id="R-XTR-983168" name="Antigen processing: Ubiquitination &amp; Proteasome degradation"/>
            <pathway-xref db="MetaCyc" id="PWY-7511" name="protein ubiquitination"/>
          </entry>
          <signature-library-release library="PROSITE_PROFILES" version="2021_01"/>
        </signature>
        <model-ac>PS51292</model-ac>
        <locations>
          <profilescan-location score="20.624262" start="13" end="73">
            <location-fragments>
              <profilescan-location-fragment start="13" end="73" dc-status="CONTINUOUS"/>
            </location-fragments>
            <alignment>GSTVSHVICRICHEGD-RLIPLISPCACSGSVGTIHQVCLEKWLSTVNKDDCELCGRKFLVH</alignment>
          </profilescan-location>
        </locations>
      </profilescan-match>
      <superfamilyhmmer3-match evalue="1.1E-13">
        <signature ac="SSF57850" name="RING/U-box">
          <signature-library-release library="SUPERFAMILY" version="1.75"/>
        </signature>
        <model-ac>0050318</model-ac>
        <locations>
          <superfamilyhmmer3-location hmm-length="60" start="16" end="71">
            <location-fragments>
              <superfamilyhmmer3-location-fragment start="16" end="71" dc-status="CONTINUOUS"/>
            </location-fragments>
          </superfamilyhmmer3-location>
        </locations>
      </superfamilyhmmer3-match>
    </matches>
  </protein>
  <protein>
    <sequence md5="57a3fa10de84d6edd5aa8f96ab18ee74">KNNKDDRNNSGQERMGCAQSVDDETLRNRRINRELYRDYSTDAQIVKLLLLGAGESGKSTIVKQMKLLHAVNDRATTGFSDEEKVEAQRAIYANIMDSIVALIEAMENFGLKLNNNRLEEDKFKVLRFAMNNESHRPPEDVVMAMKNLWRDGVIQACYQRRNEFQMNDSAEYFLKDLDRVCSKDFIPNDQDVLRTRVITSGIVKIEFQFRKLRFHMFDVGGQRSERKKWIHCFDNVTAVLFIISLSEYDQVLFEDNQTNRMHESLNLFASIVNNIHFKTKPFIVFFNKKDLFEDKLKHKSIRIAFPDYTGDKSFESTSDFIIDKYLNQSQVSSKRRAIYPHLTTATDTELVNRVFTNVSDIILNDILKDIGLN</sequence>
    <xref id="TCALIF_00538-PA" name="TCALIF_00538-PA protein Name:&quot;Similar to Guanine nucleotide-binding protein G(o) subunit alpha (Locusta migratoria)&quot; AED:0.05 eAED:0.05 QI:613|1|1|1|0.5|0.66|3|441|373"/>
    <matches>
      <fingerprints-match evalue="4.5E-48" graphscan="IIIII">
        <signature ac="PR00318" desc="Alpha G protein (transducin) signature" name="GPROTEINA">
          <entry ac="IPR001019" desc="Guanine nucleotide binding protein (G-protein), alpha subunit" name="Gprotein_alpha_su" type="FAMILY">
            <go-xref category="MOLECULAR_FUNCTION" db="GO" id="GO:0019001" name="guanyl nucleotide binding"/>
            <go-xref category="MOLECULAR_FUNCTION" db="GO" id="GO:0003924" name="GTPase activity"/>
            <go-xref category="MOLECULAR_FUNCTION" db="GO" id="GO:0031683" name="G-protein beta/gamma-subunit complex binding"/>
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        </signature>
        <model-ac>PR00318</model-ac>
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              <fingerprints-location-fragment start="282" end="291" dc-status="CONTINUOUS"/>
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              <fingerprints-location-fragment start="47" end="62" dc-status="CONTINUOUS"/>
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            <pathway-xref db="Reactome" id="R-DME-418555" name="G alpha (s) signalling events"/>
            <pathway-xref db="Reactome" id="R-MMU-9013148" name="CDC42 GTPase cycle"/>
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            <pathway-xref db="Reactome" id="R-MMU-434316" name="Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion"/>
            <pathway-xref db="Reactome" id="R-DME-392170" name="ADP signalling through P2Y purinoceptor 12"/>
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            <pathway-xref db="Reactome" id="R-RNO-418594" name="G alpha (i) signalling events"/>
            <pathway-xref db="Reactome" id="R-HSA-9009391" name="Extra-nuclear estrogen signaling"/>
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            <pathway-xref db="Reactome" id="R-HSA-432040" name="Vasopressin regulates renal water homeostasis via Aquaporins"/>
            <pathway-xref db="Reactome" id="R-HSA-9013149" name="RAC1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-CFA-392170" name="ADP signalling through P2Y purinoceptor 12"/>
            <pathway-xref db="Reactome" id="R-RNO-381753" name="Olfactory Signaling Pathway"/>
            <pathway-xref db="Reactome" id="R-BTA-418594" name="G alpha (i) signalling events"/>
            <pathway-xref db="Reactome" id="R-MMU-416482" name="G alpha (12/13) signalling events"/>
            <pathway-xref db="Reactome" id="R-HSA-416482" name="G alpha (12/13) signalling events"/>
            <pathway-xref db="Reactome" id="R-HSA-434316" name="Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion"/>
            <pathway-xref db="Reactome" id="R-RNO-381771" name="Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)"/>
            <pathway-xref db="Reactome" id="R-DDI-418597" name="G alpha (z) signalling events"/>
            <pathway-xref db="Reactome" id="R-DDI-112043" name="PLC beta mediated events"/>
            <pathway-xref db="Reactome" id="R-DME-428930" name="Thromboxane signalling through TP receptor"/>
            <pathway-xref db="Reactome" id="R-MMU-400042" name="Adrenaline,noradrenaline inhibits insulin secretion"/>
            <pathway-xref db="Reactome" id="R-DME-9009391" name="Extra-nuclear estrogen signaling"/>
            <pathway-xref db="Reactome" id="R-DME-399997" name="Acetylcholine regulates insulin secretion"/>
            <pathway-xref db="Reactome" id="R-SPO-399997" name="Acetylcholine regulates insulin secretion"/>
            <pathway-xref db="Reactome" id="R-RNO-193648" name="NRAGE signals death through JNK"/>
            <pathway-xref db="Reactome" id="R-RNO-434316" name="Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion"/>
            <pathway-xref db="Reactome" id="R-RNO-416476" name="G alpha (q) signalling events"/>
            <pathway-xref db="Reactome" id="R-MMU-392851" name="Prostacyclin signalling through prostacyclin receptor"/>
            <pathway-xref db="Reactome" id="R-DDI-2485179" name="Activation of the phototransduction cascade"/>
            <pathway-xref db="Reactome" id="R-HSA-418592" name="ADP signalling through P2Y purinoceptor 1"/>
            <pathway-xref db="Reactome" id="R-HSA-456926" name="Thrombin signalling through proteinase activated receptors (PARs)"/>
            <pathway-xref db="Reactome" id="R-RNO-4086398" name="Ca2+ pathway"/>
            <pathway-xref db="Reactome" id="R-HSA-418597" name="G alpha (z) signalling events"/>
            <pathway-xref db="Reactome" id="R-SPO-416482" name="G alpha (12/13) signalling events"/>
            <pathway-xref db="Reactome" id="R-SCE-9013148" name="CDC42 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-CFA-400042" name="Adrenaline,noradrenaline inhibits insulin secretion"/>
            <pathway-xref db="Reactome" id="R-DME-381753" name="Olfactory Signaling Pathway"/>
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            <pathway-xref db="Reactome" id="R-MMU-202040" name="G-protein activation"/>
            <pathway-xref db="Reactome" id="R-CEL-170670" name="Adenylate cyclase inhibitory pathway"/>
            <pathway-xref db="Reactome" id="R-RNO-432040" name="Vasopressin regulates renal water homeostasis via Aquaporins"/>
            <pathway-xref db="Reactome" id="R-RNO-428930" name="Thromboxane signalling through TP receptor"/>
            <pathway-xref db="Reactome" id="R-CEL-418594" name="G alpha (i) signalling events"/>
            <pathway-xref db="Reactome" id="R-HSA-9660821" name="ADORA2B mediated anti-inflammatory cytokines production"/>
            <pathway-xref db="Reactome" id="R-CEL-428930" name="Thromboxane signalling through TP receptor"/>
            <pathway-xref db="Reactome" id="R-MMU-170660" name="Adenylate cyclase activating pathway"/>
            <pathway-xref db="Reactome" id="R-RNO-9009391" name="Extra-nuclear estrogen signaling"/>
            <pathway-xref db="Reactome" id="R-CEL-9013148" name="CDC42 GTPase cycle"/>
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            <pathway-xref db="Reactome" id="R-DME-434316" name="Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion"/>
            <pathway-xref db="Reactome" id="R-DME-416476" name="G alpha (q) signalling events"/>
            <pathway-xref db="Reactome" id="R-DME-9013148" name="CDC42 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-SPO-416476" name="G alpha (q) signalling events"/>
            <pathway-xref db="Reactome" id="R-SPO-434316" name="Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion"/>
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            <pathway-xref db="Reactome" id="R-SCE-434316" name="Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion"/>
            <pathway-xref db="Reactome" id="R-SCE-416476" name="G alpha (q) signalling events"/>
            <pathway-xref db="Reactome" id="R-SPO-112043" name="PLC beta mediated events"/>
            <pathway-xref db="Reactome" id="R-DME-112043" name="PLC beta mediated events"/>
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            <pathway-xref db="Reactome" id="R-MMU-418592" name="ADP signalling through P2Y purinoceptor 1"/>
          </entry>
          <signature-library-release library="PFAM" version="34.0"/>
        </signature>
        <model-ac>PF00503</model-ac>
        <locations>
          <hmmer3-location env-end="362" env-start="25" post-processed="true" score="356.4" evalue="1.7E-106" hmm-start="3" hmm-end="354" hmm-length="354" hmm-bounds="C_TERMINAL_COMPLETE" start="27" end="362">
            <location-fragments>
              <hmmer3-location-fragment start="27" end="362" dc-status="CONTINUOUS"/>
            </location-fragments>
          </hmmer3-location>
        </locations>
      </hmmer3-match>
      <hmmer3-match evalue="3.7E-123" score="412.7">
        <signature ac="G3DSA:3.40.50.300" name="">
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            <pathway-xref db="Reactome" id="R-MMU-2173791" name="TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)"/>
            <pathway-xref db="Reactome" id="R-SCE-5689896" name="Ovarian tumor domain proteases"/>
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            <pathway-xref db="Reactome" id="R-DRE-372708" name="p130Cas linkage to MAPK signaling for integrins"/>
            <pathway-xref db="MetaCyc" id="PWY-6973" name="dTDP-alpha-D-olivose, dTDP-alpha-D-oliose and dTDP-alpha-D-mycarose biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-SCE-9696273" name="RND1 GTPase cycle"/>
            <pathway-xref db="Reactome" id="R-MMU-6791226" name="Major pathway of rRNA processing in the nucleolus and cytosol"/>
            <pathway-xref db="Reactome" id="R-SCE-110312" name="Translesion synthesis by REV1"/>
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            <pathway-xref db="MetaCyc" id="PWY-7631" name="arctigenin and isoarctigenin biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-RNO-525793" name="Myogenesis"/>
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            <pathway-xref db="Reactome" id="R-RNO-6794361" name="Neurexins and neuroligins"/>
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            <pathway-xref db="Reactome" id="R-RNO-264642" name="Acetylcholine Neurotransmitter Release Cycle"/>
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            <pathway-xref db="Reactome" id="R-HSA-5578775" name="Ion homeostasis"/>
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            <pathway-xref db="Reactome" id="R-RNO-5620924" name="Intraflagellar transport"/>
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            <pathway-xref db="Reactome" id="R-MMU-9615933" name="Postmitotic nuclear pore complex (NPC) reformation"/>
            <pathway-xref db="Reactome" id="R-HSA-5658442" name="Regulation of RAS by GAPs"/>
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            <pathway-xref db="Reactome" id="R-GGA-68962" name="Activation of the pre-replicative complex"/>
            <pathway-xref db="MetaCyc" id="PWY-8283" name="lipid IVA biosynthesis (generic)"/>
            <pathway-xref db="MetaCyc" id="PWY-7591" name="okenone biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-RNO-170984" name="ARMS-mediated activation"/>
            <pathway-xref db="Reactome" id="R-CEL-1234176" name="Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha"/>
            <pathway-xref db="Reactome" id="R-CEL-983170" name="Antigen Presentation: Folding, assembly and peptide loading of class I MHC"/>
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            <pathway-xref db="Reactome" id="R-HSA-203927" name="MicroRNA (miRNA) biogenesis"/>
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            <pathway-xref db="Reactome" id="R-DDI-9603798" name="Class I peroxisomal membrane protein import"/>
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            <pathway-xref db="Reactome" id="R-CEL-204005" name="COPII-mediated vesicle transport"/>
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            <pathway-xref db="Reactome" id="R-MMU-432040" name="Vasopressin regulates renal water homeostasis via Aquaporins"/>
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            <pathway-xref db="Reactome" id="R-RNO-418592" name="ADP signalling through P2Y purinoceptor 1"/>
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            <pathway-xref db="Reactome" id="R-DDI-77387" name="Insulin receptor recycling"/>
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            <pathway-xref db="Reactome" id="R-SSC-382556" name="ABC-family proteins mediated transport"/>
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            <pathway-xref db="MetaCyc" id="PWY-7564" name="bacimethrin and bacimethrin pyrophosphate biosynthesis"/>
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            <pathway-xref db="Reactome" id="R-SCE-674695" name="RNA Polymerase II Pre-transcription Events"/>
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