Pathway_ID Pathway_Name Accession_Count Accessions KEGG: 00250+6.3.5.5 Alanine, aspartate and glutamate metabolism 1 EFA10197.1 Reactome: R-HSA-5689896 Ovarian tumor domain proteases 8 EFA09636.1;EFA07465.1;EFA02110.1;KYB29359.1;EFA02513.1;EFA13272.2;EFA02851.1;KYB29360.1 KEGG: 00720+1.5.1.5+3.5.4.9 Carbon fixation pathways in prokaryotes 2 EFA07236.1;EFA07809.2 Reactome: R-HSA-5601884 PIWI-interacting RNA (piRNA) biogenesis 8 EFA02892.1;EFA05896.1;KYB28470.1;EFA05226.1;EFA03150.1;EFA07031.1;KYB26001.1;EFA06560.1 MetaCyc: PWY-7176 UTP and CTP de novo biosynthesis 9 EEZ99726.1;EFA03917.1;EFA11131.1;EFA07171.1;KYB28254.1;KYB26165.1;EEZ98594.1;EEZ99788.2;EFA06562.1 MetaCyc: PWY-7181 Pyrimidine deoxyribonucleosides degradation 1 EFA08865.1 Reactome: R-HSA-8939902 Regulation of RUNX2 expression and activity 44 EFA08798.1;EFA09524.2;EFA04054.1;EFA05865.1;EFA07261.2;EEZ97564.1;EFA05105.1;EFA03630.2;EFA03019.1;EFA02331.1;EEZ98185.1;EFA09518.2;KYB27618.1;EFA07659.2;EFA05871.2;EFA08601.1;EFA07110.1;EFA05912.1;KYB29359.1;KYB26545.1;EFA05370.2;KYB25309.1;EFA04284.1;KYB24713.1;EEZ99004.1;EFA05833.1;EFA02110.1;EEZ99493.1;EFA08658.1;EFA02345.1;EFA13218.1;EFA08911.2;KYB27557.1;KYB29360.1;EFA03341.1;KYB26764.1;EFA02847.1;EEZ97876.1;KYB27556.1;EFA08664.1;EFA06200.1;EFA06741.1;EFA06519.1;EFA11079.1 Reactome: R-HSA-2024096 HS-GAG degradation 15 KYB26527.1;EFA07843.2;EFA02249.1;EFA00827.1;EFA03369.2;EFA07842.1;EFA11584.2;KYB26528.1;KYB27868.1;KYB27316.1;EFA08854.1;KYB29004.1;KYB27768.1;EFA00684.1;EFA07841.1 KEGG: 00330+4.1.1.50 Arginine and proline metabolism 1 EFA07994.1 KEGG: 00630+1.1.1.37 Glyoxylate and dicarboxylate metabolism 2 EFA04972.1;EFA02482.1 KEGG: 00220+6.3.1.2 Arginine biosynthesis 2 EEZ99821.1;EEZ97848.1 KEGG: 00400+2.6.1.5 Phenylalanine, tyrosine and tryptophan biosynthesis 1 EFA03251.1 KEGG: 00600+3.2.1.22 Sphingolipid metabolism 3 KYB26654.1;EFA06705.2;EFA01818.1 Reactome: R-HSA-163754 Insulin effects increased synthesis of Xylulose-5-Phosphate 1 EEZ98187.1 Reactome: R-HSA-162710 Synthesis of glycosylphosphatidylinositol (GPI) 17 KYB26258.1;EFA01898.1;KYB26259.1;EFA04392.1;EFA04308.1;KYB26700.1;EFA06524.1;EFA00721.2;EFA04752.1;EFA04992.1;KYB25715.1;EFA04229.1;KYB29870.1;KYB29869.1;KYB26202.1;KYB27910.1;EFA00579.1 KEGG: 00930+3.1.1.17 Caprolactam degradation 2 EFA10016.2;EFA03133.1 KEGG: 00550+2.7.8.13 Peptidoglycan biosynthesis 2 EFA02198.2;KYB27827.1 Reactome: R-HSA-8951671 RUNX3 regulates YAP1-mediated transcription 1 KYB29367.1 Reactome: R-HSA-73856 RNA Polymerase II Transcription Termination 30 EFA09827.1;EFA01592.2;EFA05269.2;EFA10607.2;EFA05604.1;EFA08116.2;EFA12938.2;EEZ97980.2;EFA07957.1;KYB26686.1;KYB27333.1;KYB26337.1;EFA07541.2;EFA02993.1;EFA12271.1;EFA11869.1;KYB26428.1;EFA04291.1;EEZ98316.2;EEZ97191.2;EEZ98143.1;EEZ98144.2;EFA08132.1;EFA09426.1;EFA10320.1;EFA03141.1;EFA11531.2;EFA08780.1;EFA07272.1;KYB29603.1 MetaCyc: PWY-6829 Trna methylation (yeast) 9 EFA09658.1;EFA05938.1;EFA10600.1;EFA02043.1;EFA08644.2;EFA12884.2;EEZ98075.1;EFA11905.1;EFA10439.1 Reactome: R-HSA-8939243 RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known 16 EEZ97852.2;EFA10731.1;KYB29178.1;KYB29177.1;EFA10166.1;KYB25022.1;EFA11411.2;KYB25021.1;EEZ97706.2;EFA03630.2;EFA09870.1;KYB27618.1;EEZ98189.2;EFA05453.1;KYB25018.1;EFA10612.1 Reactome: R-HSA-5578749 Transcriptional regulation by small RNAs 28 KYB29364.1;EFA07823.1;KYB29271.1;KYB28401.1;EFA05896.1;EFA03859.1;EFA01782.2;EFA01249.2;KYB28630.1;EEZ98695.2;EFA05226.1;KYB26001.1;EFA04928.2;EFA06560.1;EFA03150.1;KYB29624.1;EFA10538.1;EFA09537.1;EFA11141.2;EFA05993.1;EFA00605.1;EFA00581.2;EFA03584.1;KYB28470.1;EFA11447.2;EEZ97868.2;KYB24563.1;EFA07031.1 KEGG: 00270+4.2.1.22 Cysteine and methionine metabolism 1 KYB26716.1 KEGG: 00770+2.7.1.33 Pantothenate and CoA biosynthesis 2 KYB29463.1;KYB29462.1 MetaCyc: PWY-3561 Choline biosynthesis III 2 KYB27775.1;EFA02113.2 Reactome: R-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression 89 EFA00209.1;EFA07030.1;EFA05867.1;EFA01805.1;EFA02110.1;EFA11837.1;EFA08168.1;EFA08849.1;EFA00505.1;EFA00935.2;EEZ97412.1;EFA06382.1;EEZ97313.1;EFA10201.2;EFA08054.1;EFA06707.1;EFA03533.1;EFA02992.1;EFA09212.1;EFA06341.1;EFA08624.1;EFA06574.1;KYB27567.1;EFA09067.1;EFA08366.2;EFA01731.1;EEZ98728.1;EEZ99942.1;EFA13254.1;EFA02268.1;EFA03346.1;EEZ97224.1;EEZ99099.1;EFA07141.1;EFA04946.1;KYB29359.1;EFA04453.1;EFA02145.1;EFA13692.2;EEZ97379.1;EFA05170.2;EFA06534.1;EFA07164.1;EFA02257.1;EFA03236.1;EFA11360.1;KYB25876.1;EFA10123.1;EFA10462.1;KYB29360.1;EFA02592.1;EFA10173.2;EFA05803.1;EEZ97360.2;EFA10183.1;EFA01765.1;EFA03478.1;EFA03441.1;EFA09345.2;EFA02515.1;EEZ98858.1;KYB27741.1;EEZ98503.1;EEZ99023.1;EFA05373.1;KYB27801.1;EFA11293.1;KYB26424.1;EFA04159.1;EFA09970.1;KYB29621.1;EFA09390.1;EFA04093.1;EEZ99635.1;EFA10969.1;EEZ98852.1;EFA03166.1;EFA08069.1;EFA07317.1;EFA12204.1;EFA01611.1;EEZ97645.1;KYB27481.1;EFA10249.1;EFA01051.1;EFA02554.1;EFA00163.1;EFA04120.1;EFA05471.1 Reactome: R-HSA-425410 Metal ion SLC transporters 2 EFA04852.1;EEZ98001.1 Reactome: R-HSA-8934903 Receptor Mediated Mitophagy 3 EFA02034.1;EEZ97852.2;EEZ98297.1 Reactome: R-HSA-5578998 Defective OPLAH causes 5-oxoprolinase deficiency (OPLAHD) 2 EFA06614.2;EFA06615.2 Reactome: R-HSA-427359 SIRT1 negatively regulates rRNA expression 2 KYB24563.1;EEZ97827.2 Reactome: R-HSA-1483226 Synthesis of PI 1 EFA05079.1 Reactome: R-HSA-450341 Activation of the AP-1 family of transcription factors 2 EFA09273.1;EFA10708.1 Reactome: R-HSA-373753 Nephrin family interactions 5 EEZ99233.1;KYB27861.1;EFA03699.2;EFA02232.2;KYB27862.1 Reactome: R-HSA-912446 Meiotic recombination 19 EFA09711.2;KYB28817.1;EFA11787.2;EFA07487.1;EFA00319.1;EFA08981.1;EFA12891.1;EFA09906.2;EFA03167.2;EFA05681.1;EFA02865.1;EFA00407.2;EFA06147.1;EFA08150.1;KYB27483.1;EFA08028.2;EFA02866.1;EFA04568.2;KYB24563.1 KEGG: 00983+2.4.2.10 Drug metabolism - other enzymes 1 EFA01834.2 MetaCyc: PWY-6834 Spermidine biosynthesis III 1 EFA07994.1 KEGG: 00010+6.2.1.1 Glycolysis / Gluconeogenesis 2 EFA12019.1;EFA12933.2 KEGG: 05170+2.7.1.153 Human immunodeficiency virus 1 infection 1 EFA09848.2 Reactome: R-HSA-189451 Heme biosynthesis 10 EFA03355.2;KYB29726.1;EFA11489.1;EFA03098.1;KYB25345.1;EEZ98060.1;EFA07026.1;EEZ98095.1;EEZ97849.1;EFA10147.1 MetaCyc: PWY-7999 Vitamin K-epoxide cycle 2 KYB26129.1;EFA03079.2 Reactome: R-HSA-442982 Ras activation upon Ca2+ influx through NMDA receptor 4 KYB28360.1;KYB29108.1;EFA09715.1;EEZ99807.2 Reactome: R-HSA-211897 Cytochrome P450 - arranged by substrate type 1 EFA10239.1 MetaCyc: PWY-7733 3-hydroxyquinaldate biosynthesis 1 KYB25672.1 Reactome: R-HSA-8863795 Downregulation of ERBB2 signaling 6 KYB29360.1;KYB29359.1;EFA02110.1;EFA03198.1;EFA01355.2;EFA08658.1 KEGG: 00511+3.2.1.51 Other glycan degradation 3 KYB28628.1;KYB28627.1;EFA00166.1 Reactome: R-HSA-8854214 TBC/RABGAPs 5 EFA10139.1;EFA00138.1;EFA11143.1;EFA10119.2;EFA09042.2 MetaCyc: PWY-1622 Formaldehyde assimilation I (serine pathway) 8 EFA09609.1;EFA10506.1;EFA04972.1;EFA02482.1;EFA11310.1;EFA09610.1;EEZ98809.1;EFA09131.1 MetaCyc: PWY-922 Mevalonate pathway I 7 EFA06304.1;EFA00378.2;EFA07280.1;EFA06636.1;KYB29328.1;EFA05256.2;KYB27676.1 MetaCyc: PWY-6309 L-tryptophan degradation XI (mammalian, via kynurenine) 2 KYB25672.1;EEZ98408.1 KEGG: 00020+1.2.4.2 Citrate cycle (TCA cycle) 4 EFA10391.1;KYB27599.1;EFA04760.2;EFA05916.2 Reactome: R-HSA-3295583 TRP channels 10 KYB26442.1;KYB28200.1;EFA04635.2;EFA07529.2;KYB28196.1;EFA02795.1;EFA02859.1;EFA06982.2;KYB27779.1;KYB25489.1 KEGG: 00071+1.3.3.6 Fatty acid degradation 3 EFA11530.1;EFA09425.1;EFA09569.1 KEGG: 00480+6.3.2.3 Glutathione metabolism 2 EFA06494.1;EFA06495.2 MetaCyc: PWY-5076 L-leucine degradation III 2 EEZ98004.1;EEZ98950.2 MetaCyc: PWY-6519 8-amino-7-oxononanoate biosynthesis I 7 EFA05201.1;EFA05249.2;EFA05204.2;EFA05203.2;EFA05248.1;EFA11365.1;EEZ97866.2 MetaCyc: PWY-241 C4 photosynthetic carbon assimilation cycle, NADP-ME type 5 EFA04508.1;EFA00432.1;KYB29101.1;EFA11790.2;EEZ98484.1 Reactome: R-HSA-159230 Transport of the SLBP Dependant Mature mRNA 22 KYB28630.1;EEZ98695.2;EFA04928.2;KYB29271.1;EFA07823.1;KYB29364.1;EFA01782.2;EFA01249.2;KYB28401.1;EFA03859.1;EFA03584.1;EFA00581.2;EEZ97868.2;EFA11447.2;EEZ98143.1;EFA09537.1;EEZ98144.2;EFA11141.2;KYB29624.1;EFA05993.1;EFA00605.1;EFA10320.1 MetaCyc: PWY-8099 Tetrahydropteridine recycling 1 EFA07130.1 KEGG: 00240+3.5.4.12 Pyrimidine metabolism 1 EFA08015.1 MetaCyc: PWY-7654 (8E,10E)-dodeca-8,10-dienol biosynthesis 3 EFA04382.1;EFA05073.1;EFA08151.1 Reactome: R-HSA-167590 Nef Mediated CD4 Down-regulation 3 EFA08618.1;EFA11263.1;EFA09781.1 KEGG: 00330+1.14.11.2 Arginine and proline metabolism 2 EEZ97484.1;EEZ97485.1 KEGG: 00626+1.1.1.1 Naphthalene degradation 1 EEZ98950.2 Reactome: R-HSA-6811436 COPI-independent Golgi-to-ER retrograde traffic 28 KYB26892.1;EFA09822.2;EFA04833.1;EFA09305.2;EFA03783.1;EFA11292.1;EFA06446.1;KYB25597.1;EEZ99070.2;EFA10255.2;EEZ97229.1;EEZ99348.1;EFA09381.2;EEZ97538.1;KYB26929.1;EFA06663.1;KYB25744.1;EFA10326.1;EFA03502.1;EFA07920.2;EFA07458.1;EEZ97891.1;EEZ99331.1;KYB25072.1;EFA06187.1;EEZ97487.2;KYB26625.1;KYB25071.1 KEGG: 00240+6.3.5.5 Pyrimidine metabolism 1 EFA10197.1 MetaCyc: PWY-5101 L-isoleucine biosynthesis II 1 EEZ98004.1 Reactome: R-HSA-186763 Downstream signal transduction 3 EFA11162.1;EEZ97639.1;EFA03699.2 Reactome: R-HSA-525793 Myogenesis 4 EEZ99037.2;EFA11312.2;EFA03253.1;EFA05645.1 MetaCyc: PWY-6907 Thiamine diphosphate biosynthesis III (Staphylococcus) 2 KYB29167.1;EEZ98443.2 KEGG: 00190+3.6.1.1 Oxidative phosphorylation 2 EEZ98942.2;EFA00136.2 Reactome: R-HSA-1614517 Sulfide oxidation to sulfate 1 EEZ97850.1 Reactome: R-HSA-202433 Generation of second messenger molecules 4 EFA12319.2;KXZ75916.1;KYB28333.1;EEZ99735.2 MetaCyc: PWY-6922 L-Ndelta-acetylornithine biosynthesis 4 EFA08381.1;EFA12217.1;EFA03145.1;EEZ98981.2 Reactome: R-HSA-5620922 BBSome-mediated cargo-targeting to cilium 11 EFA06459.1;KYB26338.1;EEZ98562.1;EFA10394.1;EFA02141.1;EFA12827.1;EFA06343.1;EFA09161.1;EEZ98476.1;EFA11133.1;EEZ97857.1 KEGG: 00720+6.2.1.1 Carbon fixation pathways in prokaryotes 2 EFA12019.1;EFA12933.2 KEGG: 00260+3.1.3.3 Glycine, serine and threonine metabolism 1 EFA01638.1 KEGG: 00561+3.2.1.22 Glycerolipid metabolism 3 EFA01818.1;EFA06705.2;KYB26654.1 Reactome: R-HSA-163282 Mitochondrial transcription initiation 1 EFA08534.1 KEGG: 00500+5.3.1.9 Starch and sucrose metabolism 1 EFA07687.2 KEGG: 00030+1.1.1.47 Pentose phosphate pathway 1 EFA08452.1 Reactome: R-HSA-111367 SLBP independent Processing of Histone Pre-mRNAs 4 EFA05269.2;EFA04291.1;EEZ98143.1;EEZ98144.2 KEGG: 00130+2.5.1.39 Ubiquinone and other terpenoid-quinone biosynthesis 1 KYB26307.1 KEGG: 00073+2.3.1.20 Cutin, suberine and wax biosynthesis 3 EFA04221.1;KYB25893.1;EFA08670.2 MetaCyc: PWY-6502 8-oxo-(d)GTP detoxification I 1 EFA09048.1 Reactome: R-HSA-5654712 FRS-mediated FGFR4 signaling 1 EFA09507.1 KEGG: 00250+6.3.4.5 Alanine, aspartate and glutamate metabolism 1 EEZ97516.1 Reactome: R-HSA-2206292 MPS VII - Sly syndrome 5 KYB26528.1;EFA07843.2;KYB26527.1;EFA07841.1;EFA07842.1 Reactome: R-HSA-352230 Amino acid transport across the plasma membrane 1 EFA06898.1 KEGG: 00280+1.2.1.27 Valine, leucine and isoleucine degradation 1 KYB27796.1 MetaCyc: PWY-6365 D-myo-inositol (3,4,5,6)-tetrakisphosphate biosynthesis 1 EFA02124.1 Reactome: R-HSA-5674400 Constitutive Signaling by AKT1 E17K in Cancer 9 KYB27979.1;EEZ99088.1;EEZ97603.1;EFA02105.1;EFA07964.1;EFA00152.1;EFA09042.2;KYB27978.1;EFA10417.1 KEGG: 00480+2.3.2.2+3.4.19.13 Glutathione metabolism 4 KYB26172.1;EFA08621.1;EFA08906.2;KYB26171.1 MetaCyc: PWY-7601 Arachidonate biosynthesis IV (8-detaturase, lower eukaryotes) 21 KYB25229.1;EFA05473.2;KYB25454.1;EFA09796.1;EFA05143.1;EFA10643.2;EFA10642.1;EFA10641.2;EEZ97311.1;EFA09795.1;KYB29213.1;KYB25455.1;EFA05474.1;KYB29211.1;EFA00084.1;EFA05977.1;KYB25453.1;EFA03551.1;EFA09483.1;EFA00083.2;EFA03752.1 MetaCyc: PWY-7445 Luteolin triglucuronide degradation 1 EFA01243.1 KEGG: 00332+2.7.2.11+1.2.1.41 Carbapenem biosynthesis 1 EEZ98981.2 Reactome: R-HSA-8849469 PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 3 EFA02110.1;KYB29359.1;KYB29360.1 MetaCyc: PWY-6545 Pyrimidine deoxyribonucleotides de novo biosynthesis III 13 EFA08206.2;EEZ98594.1;KYB26165.1;EFA07171.1;EFA02202.1;KYB29374.1;EFA02203.1;EFA03919.1;EFA04414.1;EFA03825.1;EFA00847.2;EEZ99726.1;EFA03917.1 MetaCyc: PWY-7851 Coenzyme A biosynthesis II (eukaryotic) 1 EFA07751.2 Reactome: R-HSA-163841 Gamma carboxylation, hypusine formation and arylsulfatase activation 1 EFA03159.1 Reactome: R-HSA-174154 APC/C:Cdc20 mediated degradation of Securin 52 KYB29360.1;KYB27557.1;EEZ98849.2;EFA08911.2;EFA02345.1;EFA13218.1;EEZ99493.1;EEZ97989.1;EFA02110.1;EFA04231.1;EFA11079.1;EFA06519.1;EEZ98737.1;EFA06741.1;EFA06200.1;EFA08664.1;KYB27556.1;EEZ97876.1;EEZ97189.1;KYB26764.1;EFA00073.1;EFA03341.1;EFA08601.1;EFA05871.2;EFA07659.2;EFA09518.2;EEZ98185.1;EFA02331.1;EFA03019.1;EFA05105.1;EEZ97564.1;EFA07261.2;EEZ99272.2;EFA05865.1;EFA04054.1;KYB27271.1;EFA01854.1;EFA09524.2;EFA08798.1;EFA05833.1;EEZ99004.1;KYB24713.1;EFA04284.1;KYB25309.1;EFA05370.2;KYB26545.1;KYB25814.1;EFA01569.1;EFA05912.1;KYB29359.1;EFA07110.1;KYB27187.1 Reactome: R-HSA-1268020 Mitochondrial protein import 34 KYB26462.1;EFA03279.1;EFA04897.1;EFA08121.1;EFA01361.1;EFA05442.2;EFA03729.1;EEZ99113.1;EEZ99473.1;EFA05714.1;EFA03518.2;EFA08829.1;EFA00504.1;EFA02499.1;EEZ97465.1;EEZ97742.1;EEZ99676.1;EFA07428.1;KYB27877.1;EFA06877.2;EFA03596.1;KYB27071.1;EFA10229.1;KYB29586.1;KYB28050.1;EFA02443.2;EFA03505.1;EEZ98080.1;EFA00720.1;KYB26307.1;KYB27169.1;KYB25576.1;KYB27324.1;EFA07169.2 Reactome: R-HSA-77346 Beta oxidation of decanoyl-CoA to octanoyl-CoA-CoA 1 EFA04382.1 KEGG: 00910+1.4.1.14 Nitrogen metabolism 1 EFA03092.1 MetaCyc: PWY-7602 Icosapentaenoate biosynthesis V (8-desaturase, lower eukaryotes) 21 KYB29211.1;EFA05977.1;EFA00084.1;EFA03551.1;KYB25453.1;EFA03752.1;EFA00083.2;EFA09483.1;KYB25454.1;EFA09796.1;EFA05473.2;KYB25229.1;EFA10643.2;EFA05143.1;EEZ97311.1;EFA10641.2;EFA10642.1;EFA05474.1;KYB25455.1;EFA09795.1;KYB29213.1 Reactome: R-HSA-1614558 Degradation of cysteine and homocysteine 4 EFA09634.1;EFA06486.2;EFA06970.1;EFA10345.1 Reactome: R-HSA-202427 Phosphorylation of CD3 and TCR zeta chains 4 KYB27808.1;EFA04011.1;EFA01732.2;EFA02044.2 KEGG: 00480+2.5.1.16 Glutathione metabolism 2 EFA05567.1;EFA05082.1 MetaCyc: PWY-6282 Palmitoleate biosynthesis I (from (5Z)-dodec-5-enoate) 7 EFA05203.2;EFA05204.2;EFA05249.2;EFA05201.1;EFA11365.1;EEZ97866.2;EFA05248.1 MetaCyc: PWY-7179 Purine deoxyribonucleosides degradation I 4 EFA03250.2;EFA01001.1;EFA00339.1;EFA00425.1 Reactome: R-HSA-8849932 Synaptic adhesion-like molecules 3 EFA09715.1;EFA08627.2;KYB29108.1 KEGG: 00230+2.7.4.8 Purine metabolism 8 EFA00746.2;KYB27802.1;KYB27658.1;EFA11497.1;EEZ98391.1;KYB28746.1;EEZ99889.2;KYB27803.1 Reactome: R-HSA-5617472 Activation of anterior HOX genes in hindbrain development during early embryogenesis 11 EFA07031.1;EFA03150.1;KYB24563.1;KYB26001.1;EFA06560.1;EFA00645.1;KYB26838.1;EFA05226.1;KYB28470.1;EFA02517.2;EFA05896.1 Reactome: R-HSA-418885 DCC mediated attractive signaling 1 EFA03253.1 Reactome: R-HSA-168928 DDX58/IFIH1-mediated induction of interferon-alpha/beta 4 KYB29360.1;EFA08779.1;KYB29359.1;EFA02110.1 Reactome: R-HSA-975634 Retinoid metabolism and transport 12 KYB29705.1;KYB29358.1;KYB27316.1;KYB29706.1;KYB29704.1;KYB26997.1;EFA11584.2;KYB28295.1;EFA03369.2;EFA11302.1;EEZ99723.1;EFA11425.1 MetaCyc: PWY-3861 Mannitol degradation II 1 EFA01794.1 Reactome: R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly 19 KYB28630.1;EEZ98695.2;EFA04928.2;KYB29364.1;KYB29271.1;EFA07823.1;KYB28401.1;EFA03859.1;EFA01782.2;EFA01249.2;EFA00581.2;EFA03584.1;EFA11447.2;EEZ97868.2;KYB29624.1;EFA09537.1;EFA11141.2;EFA05993.1;EFA00605.1 Reactome: R-HSA-5545483 Defective Mismatch Repair Associated With MLH1 1 EFA08028.2 KEGG: 00680+2.1.2.1 Methane metabolism 1 EFA09131.1 KEGG: 00511+3.2.1.24 Other glycan degradation 10 EEZ99705.1;EFA08765.1;EFA08768.2;EEZ99704.1;EFA08767.1;EEZ99706.1;KYB25899.1;KYB25900.1;EEZ99703.1;KYB25898.1 KEGG: 00500+3.2.1.4 Starch and sucrose metabolism 1 KYB27092.1 Reactome: R-HSA-73843 5-Phosphoribose 1-diphosphate biosynthesis 1 EFA00168.2 Reactome: R-HSA-975578 Reactions specific to the complex N-glycan synthesis pathway 3 KYB27749.1;EFA12804.1;EFA02784.1 MetaCyc: PWY-5350 Thiosulfate disproportionation IV (rhodanese) 1 EFA06486.2 Reactome: R-HSA-75953 RNA Polymerase II Transcription Initiation 30 KYB25152.1;KYB29037.1;KYB25378.1;EFA05523.2;EFA05226.1;EFA02321.1;KYB26001.1;EFA11878.1;EFA06560.1;EFA03150.1;EFA03550.1;EFA00328.1;EFA03052.1;EFA06253.1;EFA03093.1;EFA05896.1;EFA00911.1;EEZ99738.1;EEZ97886.2;EFA06469.1;KYB28470.1;EFA00018.1;KYB29038.1;EEZ97398.2;EFA07031.1;EFA03759.1;EFA05897.1;EFA07055.2;EFA02310.1;EFA07302.1 KEGG: 00010+5.1.3.15 Glycolysis / Gluconeogenesis 1 EFA11215.1 MetaCyc: PWY-7379 Mrna capping II 1 EEZ99846.2 Reactome: R-HSA-70268 Pyruvate metabolism 4 EFA00070.1;EFA00132.1;EFA05578.1;EFA01008.1 Reactome: R-HSA-177929 Signaling by EGFR 3 KYB29228.1;EEZ98535.2;KYB29308.1 Reactome: R-HSA-427389 ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression 4 EFA06839.2;KYB24563.1;KYB26273.1;EFA06006.1 MetaCyc: PWY-5856 Ubiquinol-9 biosynthesis (prokaryotic) 3 KYB26307.1;KYB26214.1;EFA04400.1 KEGG: 00620+2.7.1.40 Pyruvate metabolism 7 KYB24935.1;EFA08842.1;EEZ99016.2;KYB25941.1;EEZ97193.2;EFA08832.2;KYB24934.1 Reactome: R-HSA-174411 Polymerase switching on the C-strand of the telomere 17 EFA09576.1;KYB25721.1;EFA07750.2;KYB28926.1;EFA08812.2;EFA08916.1;EFA10435.1;KYB25740.1;EFA12420.2;EFA04623.2;EFA06042.1;EFA07958.1;EFA07996.1;EFA02756.1;EFA03814.1;KYB28925.1;EFA03020.2 Reactome: R-HSA-425397 Transport of vitamins, nucleosides, and related molecules 1 EFA08955.1 MetaCyc: PWY-6799 Fatty acid biosynthesis initiation (plant mitochondria) 7 EFA05203.2;EFA05249.2;EFA05201.1;EFA05204.2;EEZ97866.2;EFA11365.1;EFA05248.1 Reactome: R-HSA-201681 TCF dependent signaling in response to WNT 6 KYB29359.1;EFA02110.1;EFA09228.1;EFA13018.1;KYB29360.1;EFA11279.1 Reactome: R-HSA-70895 Branched-chain amino acid catabolism 6 KYB27796.1;EEZ98004.1;EFA06587.2;EEZ97382.1;EFA01760.1;EFA04754.2 Reactome: R-HSA-418886 Netrin mediated repulsion signals 1 KYB27433.1 MetaCyc: PWY-6012-1 Acyl carrier protein activation 1 EEZ97421.2 MetaCyc: PWY-8086 (S)-lactate fermentation to propanoate, acetate and hydrogen 5 KYB27787.1;EFA03144.1;EFA02482.1;EFA01008.1;EFA04972.1 KEGG: 00053+1.1.1.22 Ascorbate and aldarate metabolism 1 KYB28935.1 MetaCyc: PWY-6397 Mycolyl-arabinogalactan-peptidoglycan complex biosynthesis 3 KYB26631.1;EFA06670.2;EFA06422.2 Reactome: R-HSA-110373 Resolution of AP sites via the multiple-nucleotide patch replacement pathway 3 KXZ75899.1;EFA12889.2;KYB26857.1 MetaCyc: PWY-7833 Biosynthesis of Lewis epitopes (H. pylori) 1 EEZ98997.2 Reactome: R-HSA-4549356 Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2 2 EFA02198.2;KYB27827.1 KEGG: 00010+1.2.4.1 Glycolysis / Gluconeogenesis 2 EFA00070.1;EFA00132.1 Reactome: R-HSA-8964011 HDL clearance 1 EFA05060.1 MetaCyc: PWY-6679 Jadomycin biosynthesis 1 EFA05436.2 KEGG: 00010+5.3.1.9 Glycolysis / Gluconeogenesis 1 EFA07687.2 KEGG: 00400+1.14.16.1 Phenylalanine, tyrosine and tryptophan biosynthesis 1 EEZ99507.1 MetaCyc: PWY-5738 GDP-6-deoxy-D-talose biosynthesis 1 EFA01082.1 Reactome: R-HSA-389359 CD28 dependent Vav1 pathway 1 EFA03253.1 Reactome: R-HSA-9634285 Constitutive Signaling by Overexpressed ERBB2 1 EFA03198.1 MetaCyc: PWY-5669 Phosphatidylserine and phosphatidylethanolamine biosynthesis I 1 KYB29477.1 KEGG: 00565+3.1.3.4 Ether lipid metabolism 2 EFA07054.2;KYB26367.1 MetaCyc: PWY-7920 Complex N-linked glycan biosynthesis (plants) 1 EFA12804.1 KEGG: 00970+2.1.2.9 Aminoacyl-tRNA biosynthesis 4 EEZ98405.2;KYB29131.1;KYB25818.1;EFA05437.1 KEGG: 00500+2.4.1.1 Starch and sucrose metabolism 1 EFA02541.1 Reactome: R-HSA-2691232 Constitutive Signaling by NOTCH1 HD Domain Mutants 11 KYB27259.1;KYB29308.1;KYB29360.1;EFA03528.1;KYB26560.1;KYB29228.1;EEZ98535.2;EFA10954.1;KYB29359.1;EFA07122.1;EFA02110.1 MetaCyc: PWY-7400 L-arginine biosynthesis IV (archaebacteria) 3 EFA10197.1;EFA11668.2;EEZ97516.1 Reactome: R-HSA-5576894 Phase 1 - inactivation of fast Na+ channels 1 EFA10968.1 MetaCyc: PWY-5147 Oleate biosynthesis I (plants) 7 EFA05249.2;EFA05201.1;EFA05204.2;EFA05203.2;EFA05248.1;EFA11365.1;EEZ97866.2 Reactome: R-HSA-1963642 PI3K events in ERBB2 signaling 1 EFA01355.2 Reactome: R-HSA-5693548 Sensing of DNA Double Strand Breaks 4 EFA07487.1;EFA04568.2;EFA11787.2;EFA05681.1 KEGG: 00450+1.8.1.9 Selenocompound metabolism 2 EFA02207.2;EEZ99907.2 MetaCyc: PWY-6174 Mevalonate pathway II (archaea) 5 EFA06304.1;EFA07280.1;KYB27676.1;EFA05256.2;EFA06636.1 Reactome: R-HSA-6803211 TP53 Regulates Transcription of Death Receptors and Ligands 2 EFA12882.1;EFA12881.2 Reactome: R-HSA-8935964 RUNX1 regulates expression of components of tight junctions 2 KYB27618.1;EFA03630.2 Reactome: R-HSA-5654727 Negative regulation of FGFR2 signaling 4 KYB29360.1;EFA10708.1;KYB29359.1;EFA02110.1 KEGG: 00920+2.7.1.25 Sulfur metabolism 1 EFA13134.1 Reactome: R-HSA-2559585 Oncogene Induced Senescence 6 EFA02110.1;KYB25778.1;KYB29359.1;EFA10708.1;KYB29360.1;EFA08972.2 MetaCyc: PWY-7340 9-cis, 11-trans-octadecadienoyl-CoA degradation (isomerase-dependent, yeast) 3 EFA11530.1;EFA09425.1;EFA09569.1 KEGG: 00230+3.6.1.29 Purine metabolism 1 EFA01543.1 MetaCyc: PWY-5659 GDP-mannose biosynthesis 3 EFA07687.2;EFA07975.2;EFA01794.1 KEGG: 00010+3.1.3.11 Glycolysis / Gluconeogenesis 2 KYB27612.1;EEZ98675.1 KEGG: 00052+5.1.3.2 Galactose metabolism 3 EFA06422.2;EFA06670.2;KYB26631.1 Reactome: R-HSA-6811440 Retrograde transport at the Trans-Golgi-Network 21 EFA00369.1;EFA11083.2;EFA10214.2;KYB29402.1;EFA06481.2;EFA03811.1;EFA02659.1;EFA11346.2;EFA03408.1;EFA07645.2;EFA12034.1;EFA00297.1;EFA09922.2;EFA11398.1;EFA04902.1;EFA03151.1;KYB28874.1;EFA06979.1;EFA12234.1;EFA11080.2;EFA02441.1 MetaCyc: PWY-5665 Vanillin biosynthesis I 1 EFA05733.1 KEGG: 00510+2.7.8.15 N-Glycan biosynthesis 2 EFA02198.2;KYB27827.1 Reactome: R-HSA-446203 Asparagine N-linked glycosylation 5 EFA03003.1;EFA11223.1;KYB25413.1;EFA09462.2;EFA07387.1 MetaCyc: PWY-7805 (aminomethyl)phosphonate degradation 3 EFA00136.2;EEZ98942.2;EFA06669.1 KEGG: 00240+3.5.4.5 Pyrimidine metabolism 1 EFA08865.1 Reactome: R-HSA-445144 Signal transduction by L1 2 EEZ97852.2;EFA10708.1 Reactome: R-HSA-432142 Platelet sensitization by LDL 10 EFA12064.1;EFA05992.2;KYB26383.1;KYB26997.1;KYB29704.1;KYB29706.1;KYB29705.1;EFA11425.1;KYB26642.1;EFA11302.1 Reactome: R-HSA-9609736 Assembly and cell surface presentation of NMDA receptors 17 KYB28360.1;EFA11292.1;EFA09822.2;EFA04833.1;KYB26929.1;EFA06663.1;EEZ99348.1;EFA09715.1;EEZ97229.1;EEZ99659.1;EEZ99070.2;EEZ97891.1;KYB29108.1;EEZ99807.2;KYB26625.1;EFA06187.1;EEZ99331.1 Reactome: R-HSA-2206305 MPS IIID - Sanfilippo syndrome D 1 EFA04898.1 Reactome: R-HSA-8964058 HDL remodeling 1 EFA09849.1 KEGG: 00966+2.6.1.42 Glucosinolate biosynthesis 1 EEZ98004.1 MetaCyc: PWY-5892 Menaquinol-12 biosynthesis 2 KYB27131.1;EFA05173.2 KEGG: 00900+2.3.3.10 Terpenoid backbone biosynthesis 1 EFA06304.1 Reactome: R-HSA-8875360 InlB-mediated entry of Listeria monocytogenes into host cell 5 KYB29360.1;EFA02110.1;KYB29359.1;EFA09116.1;EFA11193.1 MetaCyc: PWY-7625 Phosphatidylinositol biosynthesis II (eukaryotes) 1 EFA05079.1 Reactome: R-HSA-72165 mRNA Splicing - Minor Pathway 32 EFA12926.2;EFA07389.1;EFA04291.1;KYB28470.1;EEZ97398.2;EFA07031.1;EFA10322.1;KYB25152.1;EFA05226.1;KYB26001.1;EFA01147.1;EFA05604.1;EFA05269.2;EFA03550.1;EFA03150.1;EEZ98144.2;EEZ98143.1;EEZ97219.1;EFA09904.1;EFA06205.1;EFA08170.1;KYB29542.1;EFA08458.1;KYB25540.1;EFA00843.1;EFA05896.1;KYB27000.1;EEZ97873.1;EFA08376.1;EFA13035.1;EFA06003.1;EFA06560.1 Reactome: R-HSA-3928663 EPHA-mediated growth cone collapse 2 KYB27402.1;EFA04406.2 KEGG: 00740+3.1.3.2 Riboflavin metabolism 1 KYB24625.1 MetaCyc: PWY-5737 (5R)-carbapenem carboxylate biosynthesis 1 EFA08381.1 Reactome: R-HSA-139853 Elevation of cytosolic Ca2+ levels 2 EFA11212.2;KYB29732.1 Reactome: R-HSA-8939242 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes 2 KYB27618.1;EFA03630.2 MetaCyc: PWY-7725 Arachidonate biosynthesis V (8-detaturase, mammals) 21 KYB29211.1;EFA00084.1;EFA05977.1;EFA03551.1;KYB25453.1;EFA00083.2;EFA03752.1;EFA09483.1;EFA09796.1;KYB25454.1;EFA05473.2;KYB25229.1;EFA05143.1;EFA10643.2;EFA10641.2;EEZ97311.1;EFA10642.1;EFA05474.1;EFA09795.1;KYB29213.1;KYB25455.1 MetaCyc: PWY-7900 Glycogen biosynthesis III (from alpha-maltose 1-phosphate) 8 EFA11030.1;EEZ98450.1;KYB29170.1;EEZ98454.1;EEZ98452.1;KYB29169.1;EEZ98206.2;EEZ98451.1 Reactome: R-HSA-170660 Adenylate cyclase activating pathway 14 KYB27619.1;EFA03954.2;KYB25556.1;EFA03628.1;KYB27523.1;KYB28863.1;KYB25554.1;EFA03629.2;EFA03625.2;EFA10712.2;EFA01439.2;KYB25552.1;KYB25555.1;KYB25553.1 KEGG: 00401+2.6.1.5 Novobiocin biosynthesis 1 EFA03251.1 Reactome: R-HSA-430039 mRNA decay by 5' to 3' exoribonuclease 11 EFA08353.1;EFA12063.2;EEZ97873.1;EFA06064.2;EFA10020.1;EFA04447.2;EFA13273.1;EFA03462.2;EFA00508.1;EFA09312.2;EEZ97803.1 Reactome: R-HSA-2644606 Constitutive Signaling by NOTCH1 PEST Domain Mutants 27 EFA04105.2;KYB29228.1;EFA11522.2;EEZ99767.1;KYB27259.1;EFA03528.1;EFA08457.1;KYB29308.1;EFA05049.2;EFA02517.2;KYB29663.1;KYB29359.1;EFA02847.1;EFA04103.1;EEZ99435.2;KYB27923.1;EFA10954.1;KYB26560.1;EEZ99094.1;EFA04470.1;KYB29360.1;EFA07178.2;EFA01868.1;EFA07122.1;EFA02110.1;KYB27078.1;EEZ98535.2 KEGG: 00520+2.7.1.6 Amino sugar and nucleotide sugar metabolism 2 EFA00753.1;EFA08251.1 MetaCyc: PWY-6708 Ubiquinol-8 biosynthesis (prokaryotic) 3 EFA04400.1;KYB26214.1;KYB26307.1 KEGG: 00380+4.2.1.17+1.1.1.35 Tryptophan metabolism 3 EFA04382.1;EFA05073.1;EFA08151.1 KEGG: 00051+3.1.3.11 Fructose and mannose metabolism 2 KYB27612.1;EEZ98675.1 Reactome: R-HSA-9664565 Signaling by ERBB2 KD Mutants 2 EFA03198.1;EFA01355.2 Reactome: R-HSA-392517 Rap1 signalling 2 KYB25934.1;KYB25935.1 Reactome: R-HSA-2465910 MASTL Facilitates Mitotic Progression 2 EFA00805.1;EFA10576.2 Reactome: R-HSA-8854691 Interleukin-20 family signaling 2 EFA05853.2;EFA04581.1 Reactome: R-HSA-2142753 Arachidonic acid metabolism 2 EFA07993.1;EEZ98236.2 MetaCyc: PWY-3821 D-galactose detoxification 5 EFA00753.1;EFA06670.2;KYB26631.1;EFA06422.2;EFA08251.1 Reactome: R-HSA-83936 Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane 6 EFA05322.1;EFA05195.1;EFA02742.1;KYB25395.1;EFA11363.1;EFA10308.1 Reactome: R-HSA-5578999 Defective GCLC causes Hemolytic anemia due to gamma-glutamylcysteine synthetase deficiency (HAGGSD) 1 EFA04528.1 MetaCyc: PWY-7817 Type I lipoteichoic acid biosynthesis (S. aureus) 15 KYB29049.1;EFA04759.2;KYB29047.1;KYB29061.1;EEZ98328.2;KYB26617.1;KYB26618.1;EFA04441.1;EFA06874.2;KYB29060.1;KYB25925.1;KYB29048.1;EFA03802.2;EFA03942.2;EFA08801.2 Reactome: R-HSA-9634600 Regulation of glycolysis by fructose 2,6-bisphosphate metabolism 4 KYB25198.1;KYB25197.1;KYB25196.1;EFA08699.1 MetaCyc: PWY-5749 Itaconate degradation 1 EFA11202.1 Reactome: R-HSA-5693565 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks 14 EFA11787.2;EFA07487.1;EFA02110.1;EFA10575.1;KYB29359.1;KYB24996.1;EFA05681.1;KYB29360.1;KYB26324.1;EEZ97760.2;KYB24563.1;EFA06120.1;EFA04568.2;EFA07446.2 MetaCyc: PWY-7765 3-hydroxy-4-methyl-anthranilate biosynthesis II 2 EEZ98408.1;KYB25672.1 KEGG: 00730+2.7.4.3 Thiamine metabolism 10 EFA05847.1;EFA11131.1;EFA03917.1;EFA03918.2;EFA06562.1;KYB27609.1;EFA03645.2;EFA06480.1;KYB29097.1;EFA11124.1 Reactome: R-HSA-6794361 Neurexins and neuroligins 7 EFA06434.2;EFA09715.1;EFA00313.1;EFA05868.2;EFA11687.2;EFA12096.2;EEZ99659.1 KEGG: 00450+2.7.9.3 Selenocompound metabolism 1 EFA06522.1 KEGG: 00480+1.1.1.42 Glutathione metabolism 3 EFA10595.2;EFA04299.1;EFA09539.1 KEGG: 00600+3.1.3.4 Sphingolipid metabolism 2 KYB26367.1;EFA07054.2 Reactome: R-HSA-450408 AUF1 (hnRNP D0) binds and destabilizes mRNA 40 EFA02345.1;EFA13218.1;EFA08911.2;EEZ99493.1;KYB29360.1;KYB27557.1;EFA02110.1;EFA06200.1;EFA08664.1;EFA06519.1;EFA11079.1;EFA06741.1;EFA03341.1;KYB26764.1;EEZ97876.1;KYB27556.1;EFA02331.1;EEZ98185.1;EFA05105.1;EFA03019.1;EFA08601.1;EFA09518.2;EFA07659.2;EFA05871.2;EFA05865.1;EFA04054.1;EFA08798.1;EFA09524.2;EFA07261.2;EEZ97564.1;EFA04284.1;KYB25309.1;EFA05370.2;KYB24713.1;EEZ99004.1;EFA05833.1;KYB29359.1;EFA05912.1;EFA07110.1;KYB26545.1 Reactome: R-HSA-877300 Interferon gamma signaling 9 EEZ97809.1;EEZ99807.2;KYB28360.1;EFA01735.1;EEZ97810.1;EFA05000.1;KYB28974.1;KYB28975.1;EFA11142.1 Reactome: R-HSA-8949664 Processing of SMDT1 9 EFA09907.1;EFA03634.1;EFA05476.1;EFA00737.1;KYB26993.1;EFA06957.1;EFA03728.2;EFA06331.1;EEZ99702.1 KEGG: 00020+2.3.1.61 Citrate cycle (TCA cycle) 1 EFA07230.2 Reactome: R-HSA-350054 Notch-HLH transcription pathway 12 EEZ99435.2;KYB27923.1;EFA01868.1;KYB29663.1;EEZ99767.1;EFA08457.1;KYB24943.1;EEZ97204.1;EFA04105.2;EFA04470.1;EFA11522.2;EEZ99094.1 Reactome: R-HSA-70171 Glycolysis 24 EFA02005.2;EFA08842.1;EEZ97932.2;KYB24935.1;KYB29370.1;EFA00108.1;EEZ99016.2;EFA08228.2;EFA07763.1;KYB24934.1;KYB29371.1;EFA01748.1;EFA07687.2;EFA08517.1;EFA05374.1;EFA04932.1;EFA09610.1;KYB25941.1;KYB26002.1;EEZ97193.2;EEZ97931.1;EFA09609.1;EFA10506.1;EFA08832.2 KEGG: 00520+3.2.1.14 Amino sugar and nucleotide sugar metabolism 20 EFA10488.1;EFA06693.1;KYB26649.1;EFA06696.2;EFA06308.1;EFA05481.2;EFA06309.1;EFA06699.2;KYB26651.1;EFA00965.2;EFA06310.1;KYB26650.1;EFA06923.1;EFA05323.2;EFA06695.1;EFA06307.1;EFA10939.1;EFA06698.1;EFA06311.1;EFA06694.1 MetaCyc: PWY-6111 Mitochondrial L-carnitine shuttle 1 EEZ99701.1 Reactome: R-HSA-8856828 Clathrin-mediated endocytosis 30 EFA05342.1;EFA11302.1;KYB29359.1;EFA09572.1;EFA02872.2;EFA09116.1;EEZ99924.2;KYB29706.1;EFA11080.2;EFA11218.2;KYB29705.1;EFA02270.2;EFA11263.1;EFA09781.1;KYB29704.1;EFA11114.1;KYB26997.1;EFA02110.1;EFA11143.1;EFA02108.2;KYB25950.1;EFA05670.1;EFA11425.1;EFA04947.1;EFA11193.1;EFA13430.2;EFA05486.1;KYB29729.1;EFA09517.2;KYB29360.1 Reactome: R-HSA-1299308 Tandem of pore domain in a weak inwardly rectifying K+ channels (TWIK) 1 EEZ97944.1 Reactome: R-HSA-1236394 Signaling by ERBB4 4 KYB24597.1;EFA12941.2;KYB24596.1;EFA02804.1 Reactome: R-HSA-5674135 MAP2K and MAPK activation 4 EFA08276.1;EFA10708.1;KYB26173.1;EFA12722.1 KEGG: 00052+3.2.1.22 Galactose metabolism 3 EFA01818.1;EFA06705.2;KYB26654.1 Reactome: R-HSA-428890 Role of ABL in ROBO-SLIT signaling 3 EFA10858.2;KYB28309.1;KYB28308.1 KEGG: 00230+6.3.2.6 Purine metabolism 1 EEZ97680.1 MetaCyc: PWY-7858 (5Z)-dodecenoate biosynthesis II 10 EFA05203.2;EFA05204.2;EFA11365.1;EFA09425.1;EFA11530.1;EFA05248.1;EFA05249.2;EFA09569.1;EFA05201.1;EEZ97866.2 Reactome: R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) 23 EFA09822.2;EFA04833.1;KYB26892.1;EFA06446.1;KYB25597.1;EFA03783.1;EFA09305.2;EFA11292.1;EEZ97229.1;EEZ99070.2;EFA10255.2;EEZ97538.1;KYB26929.1;EFA06663.1;EEZ99348.1;EFA09381.2;EEZ97891.1;KYB25072.1;EFA06187.1;EEZ99331.1;EEZ97487.2;KYB25071.1;KYB26625.1 KEGG: 04714+2.7.11.1 Thermogenesis 55 KYB27979.1;KYB28376.1;EFA01876.2;KYB28375.1;KYB28377.1;EFA10912.2;EFA00152.1;EFA10048.1;EFA08276.1;EFA07752.1;EFA11394.1;EFA08636.2;EFA00769.1;KYB25791.1;EFA10720.1;EFA04406.2;EFA02342.2;EEZ97987.1;KYB29873.1;EFA11787.2;EFA03058.1;EEZ98574.2;EFA02105.1;EFA07964.1;EFA05720.1;KYB27138.1;KYB28437.1;EFA07410.1;KYB28837.1;KYB27978.1;EEZ99828.2;EFA11019.1;KYB28836.1;KYB28439.1;EEZ99162.2;KYB29263.1;EFA11184.1;EFA02123.1;EFA04100.2;EFA07902.1;EEZ98563.1;KYB25762.1;KYB27402.1;EFA13584.2;EFA08613.1;KYB28374.1;KYB28438.1;EFA11391.2;EFA00691.2;EFA00805.1;EFA00476.1;KYB26173.1;EFA06330.1;KYB27919.1;EFA05002.2 KEGG: 00983+1.1.1.205 Drug metabolism - other enzymes 1 EFA11857.1 Reactome: R-HSA-389513 CTLA4 inhibitory signaling 4 EFA05992.2;KYB26383.1;KYB26642.1;EFA02105.1 Reactome: R-HSA-2644607 Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling 1 EFA02847.1 Reactome: R-HSA-167152 Formation of HIV elongation complex in the absence of HIV Tat 30 EEZ97398.2;EFA07031.1;EFA00606.1;EFA00603.1;EFA06469.1;EFA00018.1;KYB28470.1;EFA07055.2;EFA04061.1;EFA10288.1;EFA02310.1;EFA07302.1;EFA12997.1;EEZ98144.2;EEZ98143.1;EFA10605.2;KYB26001.1;EFA06560.1;EFA03150.1;EFA08590.1;EFA03550.1;KYB25152.1;KYB25378.1;EFA05226.1;EFA05446.1;EFA05896.1;KYB25207.1;EFA07148.1;EFA00397.1;EFA00328.1 Reactome: R-HSA-3656237 Defective EXT2 causes exostoses 2 3 EFA11584.2;KYB27316.1;EFA03369.2 Reactome: R-HSA-912631 Regulation of signaling by CBL 5 KYB29656.1;EFA11162.1;KYB29360.1;EFA02110.1;KYB29359.1 Reactome: R-HSA-9645722 Defective Intrinsic Pathway for Apoptosis Due to p14ARF Loss of Function 1 EFA13033.1 KEGG: 00564+1.1.5.3 Glycerophospholipid metabolism 2 KYB27335.1;EFA04316.2 KEGG: 00514+2.4.1.255 Other types of O-glycan biosynthesis 2 KYB28293.1;EFA01003.1 Reactome: R-HSA-933541 TRAF6 mediated IRF7 activation 4 EFA02517.2;EFA06854.1;EFA07517.1;EFA02851.1 KEGG: 00970+6.1.1.16 Aminoacyl-tRNA biosynthesis 2 EEZ97225.1;EEZ98366.2 KEGG: 04070+2.7.7.41 Phosphatidylinositol signaling system 3 EFA04759.2;EFA04441.1;EFA03942.2 Reactome: R-HSA-2024101 CS/DS degradation 9 EFA06836.2;EFA00827.1;EFA11380.2;EFA05959.1;EFA06863.2;EFA07069.1;KYB29004.1;EFA05960.2;EEZ98597.1 KEGG: 00350+2.6.1.5 Tyrosine metabolism 1 EFA03251.1 Reactome: R-HSA-1362409 Mitochondrial iron-sulfur cluster biogenesis 8 EEZ97678.1;EFA04185.1;EFA07066.1;EFA04897.1;EEZ97482.1;KYB26466.1;EEZ98188.2;EEZ97465.1 Reactome: R-HSA-196836 Vitamin C (ascorbate) metabolism 3 EEZ99480.1;EEZ99479.1;EFA00963.1 Reactome: R-HSA-9615710 Late endosomal microautophagy 9 EFA03761.1;KYB29360.1;EEZ99668.1;EFA04901.1;EEZ97653.2;EFA07193.1;KYB29359.1;EFA02110.1;EFA04908.1 Reactome: R-HSA-180024 DARPP-32 events 9 KYB28792.1;KYB25286.1;EFA06381.2;KYB26602.1;EEZ99522.2;EFA10768.1;KYB28779.1;KYB25288.1;EEZ99469.1 KEGG: 00430+1.13.11.20 Taurine and hypotaurine metabolism 1 EFA06970.1 Reactome: R-HSA-390471 Association of TriC/CCT with target proteins during biosynthesis 15 EEZ98476.1;EEZ97857.1;EFA02100.1;EFA05962.2;EEZ99111.1;EFA02141.1;KYB26733.1;EEZ98562.1;EFA07058.2;EFA05963.2;EFA05810.1;EFA06899.2;KYB26348.1;KYB26349.1;EFA06459.1 MetaCyc: PWY-7826 Amaryllidacea alkaloids biosynthesis 1 EFA05733.1 KEGG: 05170+2.7.11.1 Human immunodeficiency virus 1 infection 55 KYB25791.1;EFA10720.1;EFA04406.2;EFA02342.2;EEZ97987.1;EFA11787.2;KYB29873.1;EFA07964.1;EFA03058.1;EFA02105.1;EEZ98574.2;EFA05720.1;KYB27138.1;KYB28437.1;EFA07410.1;KYB28837.1;KYB27978.1;EEZ99828.2;KYB27979.1;KYB28376.1;EFA01876.2;KYB28375.1;KYB28377.1;EFA10912.2;EFA00152.1;EFA10048.1;EFA08276.1;EFA00769.1;EFA07752.1;EFA08636.2;EFA11394.1;EFA00691.2;EFA11391.2;EFA00805.1;EFA00476.1;KYB26173.1;EFA06330.1;KYB27919.1;EFA05002.2;EFA11019.1;KYB28836.1;EEZ99162.2;KYB28439.1;KYB29263.1;EFA11184.1;EFA02123.1;EFA04100.2;EFA07902.1;EEZ98563.1;EFA13584.2;KYB25762.1;KYB27402.1;EFA08613.1;KYB28374.1;KYB28438.1 KEGG: 00040+2.7.7.9 Pentose and glucuronate interconversions 1 EFA06874.2 KEGG: 00071+4.2.1.17+1.1.1.211 Fatty acid degradation 1 EFA04382.1 KEGG: 00860+4.99.1.1 Porphyrin and chlorophyll metabolism 1 EFA11489.1 Reactome: R-HSA-5656121 Translesion synthesis by POLI 16 EFA02110.1;EFA08916.1;EFA08812.2;EFA04888.1;KYB27483.1;KYB25740.1;KYB29360.1;EFA12891.1;EFA09906.2;EFA12420.2;KYB29359.1;EFA09711.2;EFA06042.1;EFA02756.1;EFA03814.1;EFA03020.2 Reactome: R-HSA-3214815 HDACs deacetylate histones 11 EEZ99767.1;KYB26273.1;EFA08457.1;EFA06006.1;EFA07303.1;EFA02267.1;EFA05881.2;KYB24563.1;KYB27923.1;EFA06839.2;EEZ97816.1 MetaCyc: PWY-6608 Guanosine nucleotides degradation III 5 EFA01001.1;EFA01792.1;EFA06106.1;EFA03250.2;EFA09973.1 Reactome: R-HSA-72764 Eukaryotic Translation Termination 75 EEZ98728.1;EFA01731.1;EFA09067.1;EFA13254.1;EFA09212.1;EFA08624.1;EFA06341.1;KYB27567.1;EFA06574.1;KYB29359.1;EFA02145.1;EFA04453.1;EFA06534.1;EFA05170.2;EEZ97379.1;EFA02268.1;EFA03346.1;EEZ99099.1;EFA07141.1;EFA04946.1;EFA02110.1;EFA11837.1;EFA00505.1;EFA08168.1;EFA08849.1;EFA07030.1;EFA01805.1;EFA05867.1;EFA03533.1;EFA02992.1;EEZ97412.1;EFA00935.2;EFA10201.2;EEZ97313.1;EFA06382.1;EFA08054.1;EFA12204.1;KYB27481.1;EEZ97645.1;EFA01051.1;EFA02554.1;EFA09390.1;EFA10969.1;EFA07317.1;EFA03166.1;EEZ98852.1;EFA05471.1;EFA04120.1;EFA00163.1;EFA03478.1;EFA09345.2;EFA03441.1;EEZ98858.1;EEZ98503.1;KYB27741.1;EFA11360.1;EFA03236.1;EFA02257.1;EFA10462.1;EEZ98876.1;EFA05803.1;KYB29360.1;EFA10173.2;EFA02592.1;EFA01765.1;EFA10183.1;EEZ97360.2;KYB27801.1;KYB26424.1;EFA11293.1;EFA04159.1;EFA09970.1;KYB29621.1;EEZ99023.1;EFA05373.1 KEGG: 00520+1.1.1.22 Amino sugar and nucleotide sugar metabolism 1 KYB28935.1 Reactome: R-HSA-5689901 Metalloprotease DUBs 5 EFA02110.1;KYB29198.1;KYB29359.1;EFA10575.1;KYB29360.1 MetaCyc: PWY-5392 Reductive TCA cycle II 8 EFA04972.1;EFA11129.1;EFA02482.1;EFA11202.1;EFA03144.1;EFA03750.1;EFA07160.1;EFA05014.1 Reactome: R-HSA-4420332 Defective B3GALT6 causes EDSP2 and SEMDJL1 3 EFA11584.2;EFA03369.2;KYB27316.1 MetaCyc: PWY-882 L-ascorbate biosynthesis I (L-galactose pathway) 2 EFA07975.2;EFA01794.1 Reactome: R-HSA-351202 Metabolism of polyamines 3 EFA05567.1;EFA05082.1;EFA07994.1 Reactome: R-HSA-3065676 SUMO is conjugated to E1 (UBA2:SAE1) 1 EFA12146.1 MetaCyc: PWY-6978 Plastoquinol-9 biosynthesis II 1 KYB26307.1 Reactome: R-HSA-110320 Translesion Synthesis by POLH 20 EFA06042.1;EFA09711.2;EFA07465.1;EFA08302.2;EFA11358.1;EFA06902.2;EFA12420.2;KYB29359.1;EFA03020.2;EFA02756.1;EFA03814.1;EFA05327.2;EFA02110.1;EFA09906.2;EFA12891.1;KYB29360.1;KYB25740.1;KYB27483.1;EFA08812.2;EFA08916.1 KEGG: 00540+2.7.7.38 Lipopolysaccharide biosynthesis 1 EFA09133.1 Reactome: R-HSA-71336 Pentose phosphate pathway 7 EEZ97576.1;EFA01628.1;EFA08820.2;EFA10291.2;EFA12496.1;EEZ98187.1;EFA03025.1 Reactome: R-HSA-5334118 DNA methylation 2 KYB24563.1;KYB29654.1 Reactome: R-HSA-1663150 The activation of arylsulfatases 1 EFA04519.2 Reactome: R-HSA-6787639 GDP-fucose biosynthesis 2 EFA01082.1;EFA04892.1 Reactome: R-HSA-5649702 APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway 4 KYB29442.1;EFA06198.1;EFA06186.1;EEZ98905.1 KEGG: 00500+2.4.1.25 Starch and sucrose metabolism 2 EFA10130.2;KYB25482.1 Reactome: R-HSA-5685938 HDR through Single Strand Annealing (SSA) 25 KYB26388.1;EEZ97797.2;EFA02756.1;EFA09584.2;EFA09711.2;EFA11787.2;EFA04934.2;EFA13005.2;EFA07487.1;KYB25791.1;EFA12420.2;EFA12891.1;EFA09906.2;EFA02865.1;EEZ97282.2;EFA05681.1;KYB25740.1;KYB27483.1;KYB27777.1;EFA08916.1;EFA04568.2;EFA02866.1;EEZ97345.1;EEZ99558.2;EFA08981.1 KEGG: 00770+2.7.8.7 Pantothenate and CoA biosynthesis 1 EEZ97421.2 MetaCyc: PWY-5981 CDP-diacylglycerol biosynthesis III 12 EFA04759.2;EFA04525.1;KYB27111.1;EEZ98249.2;EFA04441.1;KYB29132.1;EEZ97257.1;EEZ97656.1;KYB29133.1;KYB27110.1;EFA02132.1;EFA03942.2 Reactome: R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) 91 EFA08054.1;EEZ97412.1;EFA00935.2;EFA10201.2;EFA06382.1;EEZ97313.1;EFA03533.1;EFA03396.2;EFA02992.1;KYB26337.1;EFA07030.1;EFA01805.1;EFA05867.1;EFA00505.1;EFA08849.1;EFA08168.1;EFA02110.1;EFA11837.1;EFA07141.1;EFA04946.1;EFA03346.1;EFA02268.1;EEZ99099.1;EFA06534.1;EFA05170.2;EFA08116.2;EEZ97379.1;KYB29359.1;EFA04453.1;EFA02145.1;KYB27567.1;EFA06574.1;EFA00043.2;EFA09212.1;EFA10466.2;EEZ98404.1;EFA08624.1;EFA06341.1;EFA13254.1;EEZ98143.1;EEZ98728.1;EFA01731.1;EFA09067.1;EEZ99023.1;EFA05373.1;EFA09970.1;KYB29621.1;KYB27801.1;EFA11293.1;EFA07541.2;KYB26424.1;EFA04159.1;EFA05803.1;KYB29360.1;EFA02592.1;EFA10173.2;EFA01765.1;EEZ97360.2;EFA11869.1;EFA10183.1;EFA03236.1;EFA11360.1;EFA02257.1;EFA10462.1;EEZ98876.1;EEZ98858.1;EEZ98503.1;KYB27741.1;EFA03478.1;KYB28836.1;EFA09345.2;EFA03441.1;KYB28837.1;EEZ97800.2;EEZ97825.1;EFA00163.1;EFA05471.1;EFA04120.1;EEZ98670.2;EFA10969.1;EFA07317.1;EFA12271.1;EFA03166.1;EEZ98852.1;EFA09390.1;EFA01051.1;EEZ98144.2;EFA02554.1;EFA12204.1;KYB27481.1;EEZ97645.1 KEGG: 00603+3.2.1.22 Glycosphingolipid biosynthesis - globo and isoglobo series 3 EFA01818.1;EFA06705.2;KYB26654.1 KEGG: 00670+6.3.4.3 One carbon pool by folate 2 EFA07236.1;EFA07237.1 MetaCyc: PWY-7346 UDP-alpha-D-glucuronate biosynthesis (from UDP-glucose) 1 KYB28935.1 KEGG: 00240+2.4.2.10 Pyrimidine metabolism 1 EFA01834.2 KEGG: 00280+2.3.3.10 Valine, leucine and isoleucine degradation 1 EFA06304.1 Reactome: R-HSA-9027276 Erythropoietin activates Phosphoinositide-3-kinase (PI3K) 1 EFA09848.2 MetaCyc: PWY-7980 ATP biosynthesis 4 EFA02908.1;EFA10717.1;EFA05714.1;EFA07428.1 MetaCyc: PWY-7656 Spodoptera littoralis pheromone biosynthesis 28 EFA04973.1;EFA05235.1;KYB26690.1;EEZ97388.1;EFA08474.2;KYB26274.1;EFA05103.1;EFA08151.1;EFA05404.1;EFA06889.2;EFA05090.1;EEZ99525.1;EFA05205.1;EFA05564.2;EFA05073.1;EFA07221.2;EEZ97452.1;EFA08449.1;EFA05024.1;EFA04974.1;EFA04382.1;KYB26083.1;KYB27109.1;EFA05233.2;EFA05234.1;EFA04917.2;EFA08470.2;EFA06888.2 Reactome: R-HSA-3322077 Glycogen synthesis 6 KYB29359.1;EFA02110.1;EFA05468.1;KYB29360.1;EFA11030.1;EFA06874.2 MetaCyc: PWY-6614 Tetrahydrofolate biosynthesis 1 EFA07671.2 MetaCyc: PWY-7839 Lacto-series glycosphingolipids biosynthesis 1 EFA12048.1 KEGG: 00564+3.1.1.4 Glycerophospholipid metabolism 22 EFA08691.1;EFA13468.1;EFA07968.1;KYB27220.1;EFA12193.1;EFA03430.2;EFA05083.2;EFA09107.1;EFA12278.1;EFA09487.1;EFA12575.1;EFA07860.2;KXZ75683.1;EEZ99784.2;EEZ98801.1;EFA13680.1;EFA12309.1;KYB27219.1;EFA11812.1;EFA12460.1;KYB26689.1;KYB27221.1 MetaCyc: PWY-1722 Formate assimilation into 5,10-methylenetetrahydrofolate 3 EFA07236.1;EFA07809.2;EFA07237.1 Reactome: R-HSA-3560783 Defective B4GALT7 causes EDS, progeroid type 3 KYB27316.1;EFA03369.2;EFA11584.2 KEGG: 00604+3.2.1.52 Glycosphingolipid biosynthesis - ganglio series 10 EFA05959.1;EFA11380.2;EFA08995.1;KYB25657.1;EFA06836.2;EFA05960.2;EEZ98597.1;EFA10268.1;EFA06863.2;EFA07069.1 Reactome: R-HSA-70221 Glycogen breakdown (glycogenolysis) 8 KYB27466.1;KYB27467.1;EFA02541.1;EFA10130.2;EFA01630.1;EFA05218.1;KYB25482.1;EFA04489.2 KEGG: 00860+2.3.1.37 Porphyrin and chlorophyll metabolism 1 EFA03355.2 KEGG: 00650+5.1.2.3+4.2.1.17+1.1.1.35 Butanoate metabolism 3 EFA05073.1;EFA08151.1;EFA04382.1 Reactome: R-HSA-375281 Hormone ligand-binding receptors 1 EFA07516.1 KEGG: 00051+5.3.1.1 Fructose and mannose metabolism 1 EFA01748.1 MetaCyc: PWY-6737 Starch degradation V 3 EFA02541.1;EFA10130.2;KYB25482.1 Reactome: R-HSA-5621575 CD209 (DC-SIGN) signaling 1 EFA02517.2 Reactome: R-HSA-72689 Formation of a pool of free 40S subunits 88 EFA05471.1;EFA04120.1;EFA00163.1;EFA02554.1;EFA01051.1;EFA10249.1;KYB27481.1;EFA01611.1;EEZ97645.1;EFA12204.1;EFA07317.1;EFA08069.1;EEZ98852.1;EFA03166.1;EFA10969.1;EEZ99635.1;EFA04093.1;EFA09390.1;KYB29621.1;EFA09970.1;EFA04159.1;EFA11293.1;KYB27801.1;KYB26424.1;EFA05373.1;EEZ99023.1;EEZ98503.1;KYB27741.1;EEZ98858.1;EFA02515.1;EFA09345.2;EFA03441.1;EFA03478.1;EFA01765.1;EEZ97360.2;EFA10183.1;EFA05803.1;KYB29360.1;EFA10173.2;EFA02592.1;EFA10462.1;KYB25876.1;EFA10123.1;EFA03236.1;EFA11360.1;EFA02257.1;EFA05170.2;EFA06534.1;EEZ97379.1;EFA13692.2;EFA04453.1;EFA02145.1;KYB29359.1;EFA04946.1;EFA07141.1;EEZ99099.1;EEZ97224.1;EFA03346.1;EFA02268.1;EFA13254.1;EEZ99942.1;EEZ98728.1;EFA01731.1;EFA08366.2;EFA09067.1;KYB27567.1;EFA06574.1;EFA06341.1;EFA08624.1;EFA09212.1;EFA02992.1;EFA03533.1;EFA06707.1;EFA08054.1;EFA10201.2;EFA06382.1;EEZ97313.1;EEZ97412.1;EFA00935.2;EFA00505.1;EFA08168.1;EFA08849.1;EFA11837.1;EFA02110.1;EFA01805.1;EFA05867.1;EFA07030.1;EFA00209.1 MetaCyc: PWY-5873 Ubiquinol-7 biosynthesis (eukaryotic) 3 KYB26307.1;KYB26214.1;EFA04400.1 KEGG: 00680+5.4.2.11 Methane metabolism 2 EEZ98809.1;EFA11310.1 MetaCyc: PWY-5466 Matairesinol biosynthesis 1 EFA01243.1 MetaCyc: PWY-801 Homocysteine and cysteine interconversion 1 KYB26716.1 Reactome: R-HSA-68689 CDC6 association with the ORC:origin complex 9 EFA06047.1;EFA06374.2;EFA10460.1;EFA05162.2;EFA11188.2;EFA03157.1;EFA06929.1;KYB29174.1;EFA03095.1 Reactome: R-HSA-4411364 Binding of TCF/LEF:CTNNB1 to target gene promoters 4 KYB28556.1;KYB28559.1;KYB28557.1;KYB28558.1 KEGG: 00760+2.7.7.18 Nicotinate and nicotinamide metabolism 1 EFA10127.2 Reactome: R-HSA-5685942 HDR through Homologous Recombination (HRR) 40 EEZ97797.2;EFA09584.2;EFA08701.2;EFA07958.1;EFA09711.2;EFA12420.2;EFA07487.1;KYB29360.1;EFA02865.1;EFA12891.1;EFA04568.2;EFA06672.2;EFA02110.1;EFA03020.2;KYB26713.1;KYB26388.1;KYB28925.1;EFA03814.1;EFA02756.1;EFA10219.1;EFA13005.2;EFA11787.2;EFA11358.1;EFA06042.1;KYB28817.1;KYB29359.1;EFA04612.2;EFA00407.2;EFA05681.1;KYB25740.1;EFA09906.2;EFA02866.1;EFA08916.1;KYB27777.1;KYB27483.1;EFA08812.2;KYB28926.1;KYB25721.1;EFA08981.1;EEZ99558.2 Reactome: R-HSA-901032 ER Quality Control Compartment (ERQC) 7 EFA06236.2;KYB27153.1;EFA03542.1;EFA02110.1;KYB29359.1;EFA08227.2;KYB29360.1 MetaCyc: PWY-7082 Ammonia oxidation IV (autotrophic ammonia oxidizers) 2 EFA01233.1;EEZ97735.1 Reactome: R-HSA-400511 Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) 4 EFA02397.1;EFA07146.1;EFA03199.1;EEZ97812.1 KEGG: 00670+2.1.2.10 One carbon pool by folate 4 EFA05357.1;EFA10911.2;EFA01139.2;EFA02777.2 MetaCyc: PWY-6433 Hydroxylated fatty acid biosynthesis (plants) 21 EFA09483.1;EFA00083.2;EFA03752.1;KYB25453.1;EFA03551.1;EFA00084.1;EFA05977.1;KYB29211.1;EFA09795.1;KYB25455.1;KYB29213.1;EFA05474.1;EFA10642.1;EEZ97311.1;EFA10641.2;EFA10643.2;EFA05143.1;KYB25229.1;KYB25454.1;EFA09796.1;EFA05473.2 KEGG: 00051+1.1.1.271 Fructose and mannose metabolism 1 EFA04892.1 KEGG: 00290+4.2.1.33 Valine, leucine and isoleucine biosynthesis 2 EFA08121.1;EFA02996.1 KEGG: 00511+3.2.1.52 Other glycan degradation 10 KYB25657.1;EFA06836.2;EFA08995.1;EFA05959.1;EFA11380.2;EFA07069.1;EFA06863.2;EEZ98597.1;EFA10268.1;EFA05960.2 Reactome: R-HSA-8986944 Transcriptional Regulation by MECP2 7 EFA11590.1;KYB25778.1;EFA09197.2;KYB26000.1;EFA08972.2;KYB25999.1;EFA04626.2 KEGG: 00330+2.7.2.11+1.2.1.41 Arginine and proline metabolism 1 EEZ98981.2 Reactome: R-HSA-75876 Synthesis of very long-chain fatty acyl-CoAs 21 EFA09795.1;KYB25455.1;KYB29213.1;EFA05474.1;EFA10642.1;EEZ97311.1;EFA10641.2;EFA05143.1;EFA10643.2;KYB25229.1;EFA05473.2;KYB25454.1;EFA09796.1;EFA09483.1;EFA03752.1;EFA00083.2;KYB25453.1;EFA03551.1;EFA00084.1;EFA05977.1;KYB29211.1 Reactome: R-HSA-9603505 NTRK3 as a dependence receptor 1 EFA00606.1 Reactome: R-HSA-5083635 Defective B3GALTL causes Peters-plus syndrome (PpS) 24 EFA01633.2;KYB26517.1;KYB26519.1;KYB29003.1;EFA01634.1;KYB29417.1;KYB26430.1;KYB26304.1;KYB26317.1;EFA05321.1;KYB29418.1;EEZ98133.1;KYB26318.1;KYB26691.1;KYB26518.1;EFA07189.2;EFA07053.2;KYB26314.1;EFA06592.2;EFA01753.1;KYB26305.1;EEZ98513.2;EFA05047.2;EFA05320.1 Reactome: R-HSA-4641262 Disassembly of the destruction complex and recruitment of AXIN to the membrane 4 EFA13272.2;KYB26642.1;KYB26383.1;EFA05992.2 KEGG: 00603+3.2.1.52 Glycosphingolipid biosynthesis - globo and isoglobo series 10 EFA05960.2;EEZ98597.1;EFA10268.1;EFA07069.1;EFA06863.2;EFA11380.2;EFA05959.1;EFA08995.1;EFA06836.2;KYB25657.1 Reactome: R-HSA-6811438 Intra-Golgi traffic 15 EFA06979.1;EFA03151.1;EFA06481.2;EFA11398.1;EFA11880.1;EFA10214.2;KYB29402.1;EFA00369.1;EFA05068.1;EFA03370.1;EFA08782.2;EFA12234.1;EFA02659.1;EFA11346.2;EFA03811.1 Reactome: R-HSA-180910 Vpr-mediated nuclear import of PICs 19 EEZ97868.2;EFA11447.2;EFA00581.2;EFA03584.1;EFA00605.1;EFA05993.1;KYB29624.1;EFA09537.1;EFA11141.2;EFA04928.2;EEZ98695.2;KYB28630.1;EFA03859.1;KYB28401.1;EFA01782.2;EFA01249.2;KYB29364.1;KYB29271.1;EFA07823.1 Reactome: R-HSA-210455 Astrocytic Glutamate-Glutamine Uptake And Metabolism 1 EEZ99821.1 Reactome: R-HSA-1368108 BMAL1:CLOCK,NPAS2 activates circadian gene expression 8 EFA10996.1;EEZ97420.1;EFA00806.2;EFA10857.2;KYB28595.1;KYB28596.1;KYB26838.1;EFA08558.1 KEGG: 00680+1.1.1.37 Methane metabolism 2 EFA02482.1;EFA04972.1 MetaCyc: PWY-7790 UMP biosynthesis II 2 EFA10197.1;EFA01834.2 KEGG: 00710+2.7.1.14 Carbon fixation in photosynthetic organisms 1 EFA10291.2 Reactome: R-HSA-8873719 RAB geranylgeranylation 7 KYB28010.1;EFA09496.2;EFA00389.1;EEZ99123.1;EFA12967.1;EFA02190.1;EFA04016.2 KEGG: 00562+2.7.8.11 Inositol phosphate metabolism 1 EFA05079.1 Reactome: R-HSA-446205 Synthesis of GDP-mannose 6 EFA01794.1;KYB26694.1;EFA02222.2;KYB27852.1;EFA05475.1;EFA07975.2 KEGG: 00310+2.3.1.61 Lysine degradation 1 EFA07230.2 Reactome: R-HSA-1912420 Pre-NOTCH Processing in Golgi 3 EFA10430.1;EEZ97204.1;KYB24943.1 Reactome: R-HSA-9665250 Resistance of ERBB2 KD mutants to AEE788 1 EFA03198.1 Reactome: R-HSA-2122948 Activated NOTCH1 Transmits Signal to the Nucleus 15 KYB27259.1;EFA07178.2;KYB29360.1;KYB29308.1;EFA03528.1;KYB26560.1;KYB29228.1;KYB27078.1;EFA10954.1;EEZ98535.2;EFA05049.2;EFA04103.1;EFA02110.1;EFA07122.1;KYB29359.1 MetaCyc: PWY-5084 2-oxoglutarate decarboxylation to succinyl-CoA 5 EFA07230.2;EFA05916.2;EFA04760.2;EFA10391.1;KYB27599.1 KEGG: 00480+3.4.11.1 Glutathione metabolism 5 EEZ97983.1;EFA07320.1;EFA01079.1;EFA10568.1;EEZ98647.1 Reactome: R-HSA-1483166 Synthesis of PA 28 KYB29132.1;EFA02132.1;KYB27335.1;KYB29133.1;EEZ97656.1;KYB27221.1;EFA03071.2;EFA04525.1;EFA06119.2;EFA08139.1;KYB27219.1;EEZ98249.2;KYB27111.1;EEZ98801.1;EFA09975.1;KYB27110.1;EEZ99784.2;EEZ97257.1;EFA03072.1;EFA02113.2;EEZ99465.2;EFA05083.2;KYB27775.1;EFA03430.2;EFA04316.2;EFA13216.1;KYB27220.1;EFA08691.1 KEGG: 00051+2.7.1.105+3.1.3.46 Fructose and mannose metabolism 4 KYB25196.1;EFA08699.1;KYB25197.1;KYB25198.1 Reactome: R-HSA-196780 Biotin transport and metabolism 8 EFA05264.2;KYB27787.1;EFA05436.2;EFA03540.1;EFA03586.1;KYB25818.1;EFA03463.2;EFA07129.2 MetaCyc: PWY-31 Canavanine degradation 1 EFA03145.1 Reactome: R-HSA-9614657 FOXO-mediated transcription of cell death genes 4 EFA10720.1;EFA09953.1;EFA02517.2;EFA01850.1 Reactome: R-HSA-1234158 Regulation of gene expression by Hypoxia-inducible Factor 1 EFA02517.2 Reactome: R-HSA-8964539 Glutamate and glutamine metabolism 10 EEZ98981.2;EEZ99054.2;EFA11037.2;EFA12217.1;EEZ98116.1;KYB25037.1;EFA00672.1;EEZ99821.1;EEZ98115.1;KYB25039.1 Reactome: R-HSA-8852276 The role of GTSE1 in G2/M progression after G2 checkpoint 52 EEZ97876.1;KYB27556.1;KYB26764.1;EFA03341.1;EFA11079.1;EFA06519.1;EFA06741.1;EFA06200.1;EEZ97891.1;EFA08664.1;EEZ97229.1;EFA02110.1;EFA06663.1;KYB29360.1;EFA04833.1;KYB27557.1;EFA08911.2;EFA13218.1;EFA02345.1;EFA11292.1;EEZ99493.1;KYB26545.1;EFA06187.1;EEZ99331.1;KYB29359.1;EFA05912.1;EFA07110.1;KYB26625.1;EFA05833.1;EEZ99004.1;KYB24713.1;KYB25309.1;EFA04284.1;EFA05370.2;EEZ97564.1;EFA07261.2;EEZ99070.2;EFA05865.1;EFA04054.1;KYB26929.1;EEZ99348.1;EFA09524.2;EFA08798.1;EFA08601.1;EFA09822.2;EFA07659.2;EFA05871.2;EFA09518.2;EFA02331.1;EEZ98185.1;EFA03019.1;EFA05105.1 MetaCyc: PWY-7661 Protein N-glycosylation (Haloferax volcanii) 1 EFA06224.2 KEGG: 00520+5.4.2.10 Amino sugar and nucleotide sugar metabolism 3 KYB25938.1;EFA09778.2;EFA10132.1 Reactome: R-HSA-5607764 CLEC7A (Dectin-1) signaling 44 KYB24713.1;EEZ99004.1;EFA05833.1;EFA05370.2;EFA04284.1;KYB25309.1;KYB26545.1;EFA07110.1;KYB29359.1;EFA05912.1;EFA09518.2;EFA07659.2;EFA05871.2;EFA08601.1;EFA05105.1;EFA03019.1;EEZ98185.1;EFA02331.1;EFA00152.1;EFA07261.2;EEZ97564.1;EFA08798.1;EFA09524.2;EFA05865.1;EFA04054.1;EFA06741.1;EFA06519.1;EFA11079.1;EFA08664.1;EEZ99274.1;EFA06200.1;KYB27556.1;EEZ97876.1;EFA03341.1;KYB26764.1;EFA02847.1;KYB27557.1;EFA02851.1;KYB29360.1;EEZ99493.1;EFA02345.1;EFA13218.1;EFA08911.2;EFA02110.1 Reactome: R-HSA-8940973 RUNX2 regulates osteoblast differentiation 3 EFA10708.1;EFA03630.2;KYB27618.1 KEGG: 00230+2.1.2.2 Purine metabolism 1 KYB25818.1 Reactome: R-HSA-3656253 Defective EXT1 causes exostoses 1, TRPS2 and CHDS 3 EFA03369.2;KYB27316.1;EFA11584.2 Reactome: R-HSA-6791462 TALDO1 deficiency: failed conversion of Fru(6)P, E4P to SH7P, GA3P 1 EEZ98187.1 Reactome: R-HSA-5173105 O-linked glycosylation 4 KYB26306.1;KYB26307.1;EFA03006.2;EFA06291.1 KEGG: 00310+4.2.1.17 Lysine degradation 1 EFA04382.1 Reactome: R-HSA-8853884 Transcriptional Regulation by VENTX 14 EEZ98737.1;EFA08972.2;EEZ98849.2;EFA01854.1;KYB27187.1;EFA00073.1;EFA04231.1;KYB27271.1;KYB25778.1;EEZ99272.2;EEZ97189.1;EFA01569.1;EEZ97989.1;KYB25814.1 MetaCyc: PWY-5451 Acetone degradation I (to methylglyoxal) 1 EFA05733.1 MetaCyc: PWY-7039 Phosphatidate metabolism, as a signaling molecule 20 EFA08801.2;EFA02113.2;EFA03802.2;KYB29061.1;KYB27775.1;KXZ75916.1;EFA12319.2;KYB28995.1;KYB27925.1;KYB29048.1;KXZ75917.1;KYB25925.1;KYB29060.1;KYB26618.1;KYB26617.1;KYB29047.1;EEZ98328.2;KYB27786.1;KYB28994.1;KYB29049.1 Reactome: R-HSA-6790901 rRNA modification in the nucleus and cytosol 41 EFA01562.1;EFA04808.1;EEZ97645.1;EEZ98728.1;EFA09067.1;EEZ98784.1;EEZ98848.1;EEZ99757.1;EFA06341.1;EFA12725.1;EFA10126.1;EFA00063.1;EFA01121.1;EFA00147.1;EFA08288.1;EEZ98071.1;EFA10489.1;KYB27790.1;EFA00102.1;EFA01833.1;KYB28065.1;EFA00286.2;EFA09757.1;EFA06414.1;EFA09871.1;EFA13038.1;EFA00178.1;EFA06004.1;EEZ98265.1;EFA05884.1;EFA08649.2;EFA01765.1;EFA07025.1;EEZ97926.2;EFA11293.1;KXZ75826.1;EFA08719.1;EEZ99856.2;KYB28440.1;EFA00591.1;EFA00915.1 Reactome: R-HSA-5632968 Defective Mismatch Repair Associated With MSH6 2 EFA11424.2;EFA10321.2 Reactome: R-HSA-167287 HIV elongation arrest and recovery 21 KYB25207.1;EFA05446.1;EFA05896.1;EFA07148.1;EFA00397.1;EFA03150.1;EFA03550.1;EFA08590.1;EFA10605.2;KYB26001.1;EFA06560.1;EFA05226.1;KYB25152.1;EFA04061.1;EFA10288.1;EFA12997.1;EFA07031.1;EFA00603.1;EFA00606.1;EEZ97398.2;KYB28470.1 Reactome: R-HSA-264870 Caspase-mediated cleavage of cytoskeletal proteins 2 EEZ99233.1;EFA00313.1 MetaCyc: PWY-7979 Protein O-mannosylation III (mammals, core M3) 8 EFA01829.1;KYB26307.1;EFA06224.2;KYB27854.1;KYB27853.1;EFA04002.2;EEZ97998.1;EFA03006.2 Reactome: R-HSA-3000471 Scavenging by Class B Receptors 7 KYB29705.1;EFA11302.1;KYB29706.1;KYB26997.1;EFA11425.1;KYB29704.1;EFA10788.2 MetaCyc: PWY-5849 Menaquinol-6 biosynthesis 2 KYB27131.1;EFA05173.2 KEGG: 00562+5.5.1.4 Inositol phosphate metabolism 1 EFA09280.1 MetaCyc: PWY-7282 4-amino-2-methyl-5-phosphomethylpyrimidine biosynthesis 5 EFA10196.1;EFA00408.1;KYB25431.1;EEZ98112.1;EEZ97659.2 Reactome: R-HSA-937041 IKK complex recruitment mediated by RIP1 4 KYB29359.1;EFA02110.1;EFA02851.1;KYB29360.1 KEGG: 00860+4.1.1.37 Porphyrin and chlorophyll metabolism 1 KYB29726.1 MetaCyc: PWY-6610 Adenine salvage 1 EFA06669.1 KEGG: 00770+2.7.1.24 Pantothenate and CoA biosynthesis 1 EFA07751.2 KEGG: 00052+2.7.1.1 Galactose metabolism 4 KYB29371.1;EEZ97931.1;EEZ97932.2;KYB29370.1 MetaCyc: PWY-7723 Bacterial bioluminescence 7 EEZ97866.2;EFA11365.1;EFA05248.1;EFA05203.2;EFA05204.2;EFA05249.2;EFA05201.1 Reactome: R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) 78 EFA07030.1;EFA05867.1;EFA01805.1;EFA02110.1;EFA11837.1;EFA08849.1;EFA08168.1;EFA00505.1;EFA00935.2;EEZ97412.1;EFA06382.1;EEZ97313.1;EFA10201.2;EFA08054.1;EFA03533.1;EFA02992.1;EFA09212.1;EFA08624.1;EFA06341.1;EFA06574.1;KYB27567.1;EFA09067.1;EEZ98728.1;EFA01731.1;EFA13254.1;EEZ98143.1;EFA02268.1;EFA03346.1;EEZ99099.1;EFA07141.1;EFA04946.1;KYB29359.1;EFA04453.1;EFA02145.1;EEZ97379.1;EFA06534.1;EFA05170.2;EFA02257.1;EFA03236.1;EFA11360.1;EEZ98876.1;EFA10462.1;EFA02592.1;KYB29360.1;EFA10173.2;EFA05803.1;EFA10183.1;EEZ97360.2;EFA01765.1;EFA03478.1;EFA03441.1;EFA09345.2;EEZ98858.1;KYB27741.1;EEZ98503.1;EEZ99023.1;EFA05373.1;KYB27801.1;EFA11293.1;KYB26424.1;EFA04159.1;EFA09970.1;KYB29621.1;EFA09390.1;EFA10969.1;EFA03166.1;EEZ98852.1;EFA07317.1;EFA12204.1;EEZ97645.1;KYB27481.1;EFA01051.1;EFA02554.1;EEZ98144.2;EFA00163.1;EEZ97825.1;EFA04120.1;EFA05471.1 KEGG: 00052+2.7.1.6 Galactose metabolism 2 EFA08251.1;EFA00753.1 MetaCyc: PWY-7922 Protein O-mannosylation II (mammals, core M1 and core M2) 8 EEZ97998.1;EFA04002.2;KYB27854.1;KYB27853.1;EFA06224.2;EFA03006.2;EFA01829.1;KYB26307.1 MetaCyc: PWY-7285 Methylwyosine biosynthesis 3 EFA12884.2;EFA10600.1;EFA10439.1 MetaCyc: PWY-7193 Pyrimidine ribonucleosides salvage I 4 EFA08865.1;EFA11381.2;EEZ97798.2;KYB28983.1 MetaCyc: PWY-7206 Pyrimidine deoxyribonucleotides dephosphorylation 2 EFA04414.1;EFA03919.1 Reactome: R-HSA-9634638 Estrogen-dependent nuclear events downstream of ESR-membrane signaling 4 EFA10708.1;EEZ99037.2;EFA02105.1;EFA09995.1 Reactome: R-HSA-2206307 MPS IIIA - Sanfilippo syndrome A 1 EFA08854.1 Reactome: R-HSA-111932 CaMK IV-mediated phosphorylation of CREB 2 KYB28360.1;EEZ99807.2 MetaCyc: PWY-5989 Stearate biosynthesis II (bacteria and plants) 7 EFA05203.2;EFA05204.2;EFA05201.1;EFA05249.2;EEZ97866.2;EFA11365.1;EFA05248.1 Reactome: R-HSA-9022537 Loss of MECP2 binding ability to the NCoR/SMRT complex 1 EFA07303.1 Reactome: R-HSA-111471 Apoptotic factor-mediated response 1 EFA13033.1 MetaCyc: PWY-6920 6-gingerol analog biosynthesis (engineered) 3 EFA11530.1;EFA09425.1;EFA09569.1 Reactome: R-HSA-383280 Nuclear Receptor transcription pathway 45 EFA04529.1;EEZ98980.2;EFA11548.1;EFA12165.2;KYB28389.1;KYB27702.1;EFA04649.1;EFA09251.2;KYB25588.1;KYB26569.1;KYB29221.1;EFA04770.2;EFA07440.2;EFA07427.1;EFA11562.1;KYB26571.1;EFA10671.1;KYB25585.1;KYB29313.1;EFA08558.1;EEZ99198.2;KYB25589.1;KYB25532.1;KYB25587.1;KYB27703.1;EFA00547.2;KYB26570.1;EFA04530.2;KYB26704.1;EFA01263.2;KYB25590.1;EFA04531.2;EEZ99212.2;EFA07486.2;EEZ99270.2;EFA11580.2;KYB26568.1;KYB25916.1;KYB25584.1;KYB27378.1;EFA01351.2;KYB25531.1;KYB26567.1;EFA05671.1;EFA07462.2 KEGG: 00680+6.2.1.1 Methane metabolism 2 EFA12019.1;EFA12933.2 KEGG: 00510+2.4.1.143 N-Glycan biosynthesis 1 EFA12804.1 Reactome: R-HSA-6804760 Regulation of TP53 Activity through Methylation 7 EFA02110.1;KYB29359.1;EFA05577.2;EFA01806.1;KYB29360.1;EFA00803.1;EFA11787.2 KEGG: 00790+4.6.1.17 Folate biosynthesis 1 EEZ98181.1 Reactome: R-HSA-72731 Recycling of eIF2:GDP 3 EEZ97197.1;EFA07164.1;EFA02717.1 KEGG: 00510+2.4.1.117 N-Glycan biosynthesis 1 EFA02177.1 Reactome: R-HSA-3000170 Syndecan interactions 4 KYB28696.1;KYB28697.1;EFA10689.2;EFA11584.2 KEGG: 00500+2.7.7.9 Starch and sucrose metabolism 1 EFA06874.2 Reactome: R-HSA-9017802 Noncanonical activation of NOTCH3 4 KYB27078.1;EFA07178.2;EFA05049.2;EFA04103.1 MetaCyc: PWY-6605 Adenine and adenosine salvage II 1 EFA06669.1 Reactome: R-HSA-2453864 Retinoid cycle disease events 2 KYB28295.1;EEZ99723.1 Reactome: R-HSA-6811555 PI5P Regulates TP53 Acetylation 1 EFA00919.1 KEGG: 00592+3.1.1.32 alpha-Linolenic acid metabolism 2 EFA11062.1;EFA11061.1 Reactome: R-HSA-210991 Basigin interactions 1 EFA06898.1 MetaCyc: PWY-7185 UTP and CTP dephosphorylation I 5 KYB29374.1;EFA07795.2;EFA01792.1;EEZ99788.2;KYB28254.1 Reactome: R-HSA-2660826 Constitutive Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant 6 KYB26560.1;EFA07122.1;KYB29228.1;KYB29308.1;EEZ98535.2;EFA10954.1 Reactome: R-HSA-110328 Recognition and association of DNA glycosylase with site containing an affected pyrimidine 6 EFA08192.2;KYB24563.1;EFA11876.2;EEZ98702.1;EFA06624.1;EFA06198.1 Reactome: R-HSA-4655427 SUMOylation of DNA methylation proteins 1 KYB29654.1 Reactome: R-HSA-6796648 TP53 Regulates Transcription of DNA Repair Genes 34 EFA00397.1;EFA05226.1;KYB25378.1;KYB25152.1;EFA03550.1;EFA03150.1;KYB26001.1;EFA10605.2;EFA12997.1;EFA10288.1;KYB28470.1;EFA00018.1;EFA00606.1;EFA08028.2;EFA00603.1;EFA07031.1;EEZ97398.2;EFA00328.1;EFA07148.1;EFA11787.2;KYB25791.1;KYB25207.1;EFA05896.1;EEZ97594.1;EFA05446.1;EFA08590.1;EFA06560.1;EEZ98882.2;EFA07302.1;EFA13288.2;EFA02310.1;EFA04061.1;EFA07055.2;EFA06469.1 Reactome: R-HSA-9634635 Estrogen-stimulated signaling through PRKCZ 1 EFA00152.1 Reactome: R-HSA-5358606 Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) 11 KYB25721.1;EFA09711.2;EFA06042.1;EFA07958.1;EFA13005.2;KYB28926.1;EFA08028.2;KYB27483.1;KYB28925.1;EFA09906.2;EFA12891.1 KEGG: 00720+1.1.1.42 Carbon fixation pathways in prokaryotes 3 EFA04299.1;EFA09539.1;EFA10595.2 KEGG: 00220+3.5.1.2 Arginine biosynthesis 1 EFA11037.2 KEGG: 00760+6.3.1.5 Nicotinate and nicotinamide metabolism 1 EFA01802.1 KEGG: 00520+1.1.1.271 Amino sugar and nucleotide sugar metabolism 1 EFA04892.1 Reactome: R-HSA-1660499 Synthesis of PIPs at the plasma membrane 6 EEZ98191.1;KYB24843.1;EFA11114.1;KYB29656.1;KYB24844.1;EFA09848.2 MetaCyc: PWY-7863 Roseoflavin biosynthesis 1 EFA06175.2 Reactome: R-HSA-8877330 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) 2 KYB27618.1;EFA03630.2 MetaCyc: PWY-6527 Stachyose degradation 10 EFA06670.2;EFA06705.2;EFA01818.1;EFA00753.1;EFA06874.2;KYB26631.1;KYB26654.1;EFA06422.2;EFA08251.1;KYB28384.1 KEGG: 00710+2.6.1.1 Carbon fixation in photosynthetic organisms 3 KYB27212.1;EFA04122.1;EFA03109.1 MetaCyc: PWY-6369 Inositol diphosphates biosynthesis 5 KYB26511.1;KYB26510.1;KYB25213.1;KYB26507.1;EFA10622.1 Reactome: R-HSA-170968 Frs2-mediated activation 1 EFA10708.1 MetaCyc: PWY-7224 Purine deoxyribonucleosides salvage 5 EFA03917.1;KYB26165.1;EFA07171.1;EEZ99726.1;EEZ98594.1 Reactome: R-HSA-480985 Synthesis of dolichyl-phosphate-glucose 3 EFA04948.1;EFA02177.1;EFA01723.1 KEGG: 00600+1.14.19.17 Sphingolipid metabolism 1 EFA05646.1 MetaCyc: PWY-5103 L-isoleucine biosynthesis III 1 EEZ98004.1 Reactome: R-HSA-6807505 RNA polymerase II transcribes snRNA genes 36 EFA06334.1;EFA05897.1;EFA03759.1;EFA05171.1;EEZ98143.1;EEZ98144.2;EFA05365.1;EFA06978.1;EFA08805.1;EFA05976.1;EFA06560.1;EFA08590.1;EFA06253.1;EFA03052.1;EFA05896.1;EFA05446.1;KYB28470.1;EFA09748.2;EEZ97398.2;EFA10179.2;EEZ98305.2;EFA07031.1;KYB29555.1;EFA12923.1;EEZ98845.2;EFA00145.2;EEZ98703.1;KYB25152.1;EFA12366.2;EFA05226.1;KYB26001.1;EFA00685.1;EFA03550.1;EFA03150.1;EFA03763.1;EFA12368.2 KEGG: 04070+2.7.1.153 Phosphatidylinositol signaling system 1 EFA09848.2 Reactome: R-HSA-381038 XBP1(S) activates chaperone genes 7 EFA10591.1;EFA03611.1;EFA10125.2;KYB25597.1;EFA10255.2;EFA02325.1;EFA00653.1 Reactome: R-HSA-167162 RNA Polymerase II HIV Promoter Escape 30 EFA11878.1;KYB26001.1;EFA06560.1;EFA03550.1;EFA03150.1;KYB25152.1;EFA02321.1;EFA05226.1;KYB29037.1;KYB25378.1;EFA05523.2;EFA03093.1;EFA05896.1;EFA00911.1;EFA06253.1;EFA00328.1;EFA03052.1;KYB29038.1;EEZ97398.2;EFA03759.1;EFA05897.1;EFA07031.1;EFA06469.1;EEZ97886.2;EEZ99738.1;EFA00018.1;KYB28470.1;EFA02310.1;EFA07055.2;EFA07302.1 Reactome: R-HSA-180585 Vif-mediated degradation of APOBEC3G 40 KYB27556.1;EEZ97876.1;KYB26764.1;EFA03341.1;EFA11079.1;EFA06519.1;EFA06741.1;EFA06200.1;EFA08664.1;EFA02110.1;KYB29360.1;KYB27557.1;EFA08911.2;EFA13218.1;EFA02345.1;EEZ99493.1;KYB26545.1;KYB29359.1;EFA05912.1;EFA07110.1;EFA05833.1;EEZ99004.1;KYB24713.1;EFA04284.1;KYB25309.1;EFA05370.2;EEZ97564.1;EFA07261.2;EFA05865.1;EFA04054.1;EFA09524.2;EFA08798.1;EFA08601.1;EFA05871.2;EFA07659.2;EFA09518.2;EEZ98185.1;EFA02331.1;EFA03019.1;EFA05105.1 Reactome: R-HSA-442660 Na+/Cl- dependent neurotransmitter transporters 1 EEZ98455.2 Reactome: R-HSA-1257604 PIP3 activates AKT signaling 9 EFA02851.1;EFA10417.1;KYB29656.1;EFA00152.1;EFA02105.1;EFA07964.1;EEZ99088.1;EFA01355.2;EFA01304.1 KEGG: 00450+2.7.7.4 Selenocompound metabolism 1 EFA13134.1 MetaCyc: PWY-5384 Sucrose degradation IV (sucrose phosphorylase) 1 EFA07687.2 Reactome: R-HSA-389661 Glyoxylate metabolism and glycine degradation 22 EFA07230.2;EFA00132.1;EFA00070.1;EFA05239.1;EEZ98826.2;EFA11496.1;EFA12932.2;EFA04760.2;EFA11170.1;KYB27599.1;EFA02248.1;EFA00550.1;EFA02475.1;EFA09724.1;KYB25739.1;KYB25738.1;EFA05916.2;EFA04003.1;EEZ98651.1;EFA10391.1;EEZ97198.1;EFA08008.1 KEGG: 00983+6.3.5.2 Drug metabolism - other enzymes 1 EFA09313.1 MetaCyc: PWY-8013 UDP-N-acetyl-D-galactosamine biosynthesis III 3 EEZ99805.2;KYB28361.1;EFA07687.2 MetaCyc: PWY-5912 2'-deoxymugineic acid phytosiderophore biosynthesis 1 EEZ97278.1 Reactome: R-HSA-212436 Generic Transcription Pathway 20 EFA11290.1;EEZ98716.2;EFA03097.1;EFA00475.1;EFA07012.2;EFA08543.1;EFA02633.1;EFA06850.2;KYB27096.1;EFA03597.1;EFA00114.1;EFA08558.1;EEZ97239.1;EFA03009.1;EFA06894.2;EFA03598.1;EFA00473.1;EFA00809.1;EFA02017.1;EFA01959.1 Reactome: R-HSA-5467340 AXIN missense mutants destabilize the destruction complex 4 EFA13272.2;KYB26642.1;KYB26383.1;EFA05992.2 KEGG: 00730+2.8.1.7 Thiamine metabolism 1 EFA04185.1 MetaCyc: PWY-5870 Ubiquinol-8 biosynthesis (eukaryotic) 3 KYB26214.1;KYB26307.1;EFA04400.1 Reactome: R-HSA-3000178 ECM proteoglycans 8 EFA01328.2;EFA06291.1;KYB27188.1;KYB28697.1;EFA04092.2;EFA10689.2;KYB28696.1;KYB28643.1 KEGG: 00710+1.1.1.37 Carbon fixation in photosynthetic organisms 2 EFA02482.1;EFA04972.1 MetaCyc: PWY-5104 L-isoleucine biosynthesis IV 1 EEZ98004.1 Reactome: R-HSA-418990 Adherens junctions interactions 3 EFA10738.2;KYB27570.1;EFA10737.2 Reactome: R-HSA-1362277 Transcription of E2F targets under negative control by DREAM complex 5 EFA06042.1;EFA03095.1;EFA01741.1;EFA08856.2;EFA02434.1 KEGG: 00230+2.7.1.25 Purine metabolism 1 EFA13134.1 KEGG: 00680+3.1.3.11 Methane metabolism 2 EEZ98675.1;KYB27612.1 MetaCyc: PWY-6854 Ethylene biosynthesis III (microbes) 7 EFA09191.1;EFA02790.1;KYB25410.1;EFA10684.1;EFA10685.2;EFA10695.2;EFA07539.1 Reactome: R-HSA-168927 TICAM1, RIP1-mediated IKK complex recruitment 4 EFA02851.1;KYB29360.1;EFA02110.1;KYB29359.1 KEGG: 00520+5.3.1.8 Amino sugar and nucleotide sugar metabolism 1 EFA01794.1 Reactome: R-HSA-418359 Reduction of cytosolic Ca++ levels 3 EFA10430.1;EFA12050.1;EFA06448.1 Reactome: R-HSA-3134975 Regulation of innate immune responses to cytosolic DNA 4 KYB29360.1;EFA08516.2;EFA02110.1;KYB29359.1 Reactome: R-HSA-1971475 A tetrasaccharide linker sequence is required for GAG synthesis 6 EFA11584.2;EFA12734.1;EFA11078.1;EFA01477.1;KYB27316.1;EFA03369.2 Reactome: R-HSA-2500257 Resolution of Sister Chromatid Cohesion 45 EFA07677.2;KYB26383.1;EFA09822.2;EFA06492.1;EEZ97419.2;EFA11447.2;EEZ99070.2;EEZ99348.1;KYB25616.1;KYB26929.1;EEZ99210.2;EFA13202.2;EFA06856.2;EFA07500.2;EEZ99331.1;KYB25072.1;EFA06187.1;EEZ97230.1;KYB25071.1;KYB26625.1;EFA07755.2;EFA05992.2;KYB26892.1;EFA04833.1;EFA09995.1;EFA11292.1;KYB25237.1;KYB27439.1;EFA09537.1;KYB25236.1;EFA00171.1;KYB26642.1;EEZ97229.1;KYB29624.1;EFA06663.1;KYB25744.1;EFA04692.2;EFA07920.2;EEZ97891.1;EFA07823.1;KYB25235.1;EFA09410.1;EEZ97487.2;EFA04506.2;KYB27370.1 Reactome: R-HSA-426496 Post-transcriptional silencing by small RNAs 7 EFA11590.1;EFA09197.2;KYB25778.1;EFA04626.2;KYB25999.1;KYB26000.1;EFA08972.2 KEGG: 00630+1.11.1.6 Glyoxylate and dicarboxylate metabolism 3 EEZ97738.1;KYB28799.1;EEZ97708.2 Reactome: R-HSA-379716 Cytosolic tRNA aminoacylation 22 EFA06771.1;KYB26719.1;EFA09968.1;EFA03148.1;KYB27572.1;EFA01911.1;EEZ99471.1;KYB24711.1;EFA11240.1;EFA00049.1;KYB29382.1;EFA02651.1;EFA03680.2;KYB25520.1;EFA06843.2;EEZ97297.1;EFA02605.2;EFA12886.1;EFA04272.1;KYB26720.1;EFA12616.1;EFA03247.1 Reactome: R-HSA-9665247 Resistance of ERBB2 KD mutants to osimertinib 1 EFA03198.1 MetaCyc: PWY-6981 Chitin biosynthesis 1 EFA07687.2 Reactome: R-HSA-512988 Interleukin-3, Interleukin-5 and GM-CSF signaling 2 KYB29656.1;EFA12064.1 Reactome: R-HSA-196741 Cobalamin (Cbl, vitamin B12) transport and metabolism 4 EFA05060.1;EFA10463.1;EFA05377.1;EEZ98479.1 Reactome: R-HSA-2029485 Role of phospholipids in phagocytosis 8 EFA02113.2;EFA07406.1;EFA07407.1;EFA11212.2;KXZ75916.1;EFA12319.2;KYB27775.1;KYB29732.1 Reactome: R-HSA-6811434 COPI-dependent Golgi-to-ER retrograde traffic 66 EEZ97229.1;EFA06663.1;EFA04833.1;KYB29659.1;EFA11529.1;EFA11292.1;EFA02556.2;EEZ97207.2;EEZ97605.1;KYB25512.1;EFA11512.2;EEZ98676.1;EFA09888.1;EFA09678.1;KYB27386.1;KYB26929.1;KYB29922.1;EEZ99348.1;EEZ99766.1;EFA11416.2;EFA10675.1;EFA10972.1;EFA09822.2;EFA11148.1;EFA08595.1;KYB27927.1;EFA08843.1;EFA04613.2;EFA07987.1;EFA04570.1;EFA05812.2;KYB26625.1;EFA07572.2;EFA01968.1;EFA07500.2;EFA07279.1;EFA07749.1;KYB26178.1;EFA08129.2;KYB26664.1;KYB27152.1;EEZ98209.1;EFA06082.2;EEZ97799.1;EFA02324.2;EFA11192.2;EFA04563.2;EFA00906.2;KYB27385.1;EFA11398.1;KYB29658.1;EFA03966.2;EEZ97891.1;EFA00856.2;EFA12234.1;KYB27151.1;EEZ99070.2;EFA13206.2;EFA11147.1;EFA06187.1;EEZ99331.1;KYB28909.1;EFA11494.1;EFA04609.1;EEZ99967.1;EFA03756.1 KEGG: 00010+4.1.1.32 Glycolysis / Gluconeogenesis 2 KYB26254.1;EFA06223.2 Reactome: R-HSA-429958 mRNA decay by 3' to 5' exoribonuclease 16 EFA06447.1;EFA02571.1;EFA06035.2;EFA07181.2;KYB28379.1;EEZ99918.1;EFA01430.2;EFA07836.1;EFA06999.1;KYB25250.1;EFA00945.2;EFA05246.1;KYB25252.1;EEZ98806.1;EFA01958.1;KYB26733.1 Reactome: R-HSA-389960 Formation of tubulin folding intermediates by CCT/TriC 12 EEZ99331.1;EFA06459.1;EEZ97229.1;EFA05810.1;EEZ99348.1;EEZ98562.1;EFA02141.1;EEZ99111.1;EFA02100.1;EEZ97857.1;EEZ98476.1;EEZ97891.1 KEGG: 00260+5.4.2.11 Glycine, serine and threonine metabolism 2 EFA11310.1;EEZ98809.1 MetaCyc: PWY-6317 D-galactose degradation I (Leloir pathway) 9 KYB29856.1;EFA06670.2;KYB29855.1;EFA01124.1;EFA06422.2;EFA00753.1;KYB26631.1;EFA08251.1;KYB28384.1 Reactome: R-HSA-400042 Adrenaline,noradrenaline inhibits insulin secretion 1 KYB25864.1 MetaCyc: PWY-6886 1-butanol autotrophic biosynthesis (engineered) 11 EFA05374.1;EFA08842.1;EFA09609.1;EFA10506.1;EFA08832.2;KYB24934.1;KYB24935.1;EEZ99016.2;KYB25941.1;EFA09610.1;EEZ97193.2 Reactome: R-HSA-8874211 CREB3 factors activate genes 3 KYB28740.1;EEZ98063.1;EFA00011.2 MetaCyc: PWY-7165 L-ascorbate biosynthesis VI (engineered pathway) 2 EFA10016.2;EFA03133.1 Reactome: R-HSA-937042 IRAK2 mediated activation of TAK1 complex 4 KYB29359.1;EFA02110.1;EFA02851.1;KYB29360.1 Reactome: R-HSA-1483191 Synthesis of PC 28 EFA07054.2;KXZ75649.1;KYB28528.1;EFA01115.1;EFA01165.1;EFA06763.1;KYB29415.1;EFA04156.1;KYB25486.1;EFA01113.1;KYB28529.1;KYB29042.1;EEZ98964.2;EEZ99262.2;EFA10286.1;KYB28984.1;KYB28985.1;KYB28737.1;KYB26367.1;KYB28357.1;KYB28736.1;KYB28734.1;EEZ97852.2;KYB26709.1;EFA12126.2;KXZ75648.1;EEZ98759.2;KYB28735.1 Reactome: R-HSA-75815 Ubiquitin-dependent degradation of Cyclin D 40 KYB27557.1;KYB29360.1;EEZ99493.1;EFA08911.2;EFA02345.1;EFA13218.1;EFA02110.1;EFA06741.1;EFA11079.1;EFA06519.1;EFA08664.1;EFA06200.1;KYB27556.1;EEZ97876.1;KYB26764.1;EFA03341.1;EFA07659.2;EFA05871.2;EFA09518.2;EFA08601.1;EFA03019.1;EFA05105.1;EFA02331.1;EEZ98185.1;EEZ97564.1;EFA07261.2;EFA09524.2;EFA08798.1;EFA05865.1;EFA04054.1;EEZ99004.1;EFA05833.1;KYB24713.1;EFA05370.2;KYB25309.1;EFA04284.1;KYB26545.1;EFA07110.1;KYB29359.1;EFA05912.1 MetaCyc: PWY-5278 Sulfite oxidation III 1 EFA13134.1 KEGG: 00260+4.2.1.22 Glycine, serine and threonine metabolism 1 KYB26716.1 KEGG: 00983+2.5.1.18 Drug metabolism - other enzymes 4 EFA00963.1;EFA08560.1;EEZ99480.1;EEZ99479.1 KEGG: 00564+3.1.1.4+3.1.1.5 Glycerophospholipid metabolism 1 KYB29358.1 KEGG: 00010+4.1.2.13 Glycolysis / Gluconeogenesis 1 EFA04932.1 Reactome: R-HSA-9636383 Prevention of phagosomal-lysosomal fusion 4 KYB29360.1;KYB29359.1;EFA02110.1;EFA09116.1 Reactome: R-HSA-5609977 Defective GALE can cause Epimerase-deficiency galactosemia (EDG) 3 EFA06422.2;EFA06670.2;KYB26631.1 KEGG: 00640+6.2.1.5 Propanoate metabolism 5 EFA11129.1;EFA11202.1;EFA03750.1;EFA07160.1;EFA05014.1 Reactome: R-HSA-5655862 Translesion synthesis by POLK 16 KYB25740.1;KYB29360.1;EFA12891.1;EFA09906.2;EFA08916.1;EFA08812.2;EFA04888.1;KYB27483.1;EFA02110.1;EFA03020.2;EFA02756.1;EFA03814.1;EFA09711.2;EFA06042.1;KYB29359.1;EFA12420.2 MetaCyc: PWY-7177 UTP and CTP dephosphorylation II 2 EEZ99788.2;KYB28254.1 KEGG: 00230+3.5.4.3 Purine metabolism 1 EFA06106.1 KEGG: 00460+2.1.2.1 Cyanoamino acid metabolism 1 EFA09131.1 KEGG: 00401+2.6.1.1 Novobiocin biosynthesis 3 EFA03109.1;KYB27212.1;EFA04122.1 MetaCyc: PWY-7391 Isoprene biosynthesis II (engineered) 7 EFA00378.2;EFA07280.1;EFA06304.1;EFA05256.2;KYB29328.1;EFA06636.1;KYB27676.1 Reactome: R-HSA-2514859 Inactivation, recovery and regulation of the phototransduction cascade 4 EFA05466.1;EEZ97675.1;EFA13129.1;EFA07131.1 Reactome: R-HSA-8964616 G beta:gamma signalling through CDC42 2 EFA03253.1;KYB25864.1 Reactome: R-HSA-77588 SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs 5 EFA04291.1;EEZ98143.1;EEZ98144.2;EFA10320.1;EFA05269.2 KEGG: 00230+3.1.3.5 Purine metabolism 1 EFA01792.1 Reactome: R-HSA-4086398 Ca2+ pathway 21 KYB25778.1;KYB29732.1;EFA04087.1;EFA11212.2;EFA09197.2;EFA12840.1;KYB28557.1;EFA08972.2;KYB28556.1;EFA11590.1;KYB27786.1;KYB27319.1;KYB25999.1;KYB25934.1;KYB28558.1;KYB26000.1;KYB25936.1;EFA04626.2;KYB25864.1;KYB25935.1;KYB28559.1 MetaCyc: PWY-8010 L-cysteine biosynthesis IX (Trichomonas vaginalis) 1 EEZ98123.1 Reactome: R-HSA-190873 Gap junction degradation 4 EFA04947.1;EFA09781.1;EEZ98246.1;EFA02270.2 Reactome: R-HSA-1169091 Activation of NF-kappaB in B cells 42 EFA09518.2;EFA05871.2;EFA07659.2;EFA08601.1;EFA05105.1;EFA03019.1;EEZ98185.1;EFA02331.1;EFA07261.2;EEZ97564.1;EFA08798.1;EFA09524.2;EFA05865.1;EFA04054.1;KYB24713.1;EEZ99004.1;EFA05833.1;EFA05370.2;KYB25309.1;EFA04284.1;KYB26545.1;EFA07110.1;KYB29359.1;EFA05912.1;KYB27557.1;KYB29360.1;EEZ99493.1;EFA02345.1;EFA13218.1;EFA08911.2;EFA02110.1;EFA06741.1;EFA06519.1;EFA11079.1;EEZ99274.1;EFA08664.1;EFA06200.1;EEZ97876.1;KYB27556.1;EFA03341.1;KYB26764.1;EFA02847.1 MetaCyc: PWY-1269 CMP-3-deoxy-D-manno-octulosonate biosynthesis 1 EFA09133.1 KEGG: 00220+6.3.4.5 Arginine biosynthesis 1 EEZ97516.1 MetaCyc: PWY-6643 Coenzyme M biosynthesis II 3 EFA03109.1;EFA04122.1;KYB27212.1 KEGG: 00053+1.13.99.1 Ascorbate and aldarate metabolism 1 EFA05415.1 Reactome: R-HSA-916853 Degradation of GABA 3 KYB25521.1;KYB25522.1;EEZ97424.1 Reactome: R-HSA-5654732 Negative regulation of FGFR3 signaling 4 KYB29360.1;EFA02110.1;KYB29359.1;EFA10708.1 KEGG: 00010+5.1.3.3 Glycolysis / Gluconeogenesis 3 EFA01124.1;KYB29855.1;KYB29856.1 Reactome: R-HSA-174417 Telomere C-strand (Lagging Strand) Synthesis 5 KYB25721.1;KYB28926.1;EFA07958.1;EFA06042.1;KYB28925.1 KEGG: 00480+4.3.2.7 Glutathione metabolism 2 EFA10955.1;EFA11426.1 Reactome: R-HSA-110329 Cleavage of the damaged pyrimidine 6 EEZ98702.1;EFA11876.2;EFA06624.1;EFA06198.1;EFA08192.2;KYB24563.1 Reactome: R-HSA-5625970 RHO GTPases activate KTN1 2 EFA03253.1;EFA02324.2 KEGG: 00620+3.1.2.6 Pyruvate metabolism 1 EFA08581.1 Reactome: R-HSA-1296052 Ca2+ activated K+ channels 1 EFA11484.1 KEGG: 00460+3.5.1.1 Cyanoamino acid metabolism 4 EFA08342.2;EEZ98638.1;EFA08343.2;EFA06327.1 MetaCyc: PWY-1801 Formaldehyde oxidation II (glutathione-dependent) 2 EFA04060.1;EEZ98950.2 Reactome: R-HSA-375165 NCAM signaling for neurite out-growth 3 EFA10708.1;EFA01607.2;EEZ99233.1 Reactome: R-HSA-3371568 Attenuation phase 1 EFA02517.2 Reactome: R-HSA-433137 Sodium-coupled sulphate, di- and tri-carboxylate transporters 4 EFA05252.2;EFA05192.1;EFA05193.2;KYB27114.1 Reactome: R-HSA-156711 Polo-like kinase mediated events 3 EFA08856.2;EFA01741.1;EFA02434.1 MetaCyc: PWY-6370 Ascorbate recycling (cytosolic) 3 EEZ99480.1;EEZ99479.1;EFA00963.1 Reactome: R-HSA-110357 Displacement of DNA glycosylase by APEX1 8 EFA06624.1;EFA11876.2;EFA00785.1;KXZ75899.1;EFA08192.2;KYB26857.1;EFA06198.1;EFA12889.2 Reactome: R-HSA-4755609 Defective DHDDS causes retinitis pigmentosa 59 2 EFA08584.1;EEZ97509.1 KEGG: 00460+2.3.2.2 Cyanoamino acid metabolism 4 KYB26172.1;EFA08621.1;EFA08906.2;KYB26171.1 Reactome: R-HSA-2871796 FCERI mediated MAPK activation 6 EEZ97169.2;KYB24949.1;EFA09273.1;EFA10708.1;EFA12319.2;KXZ75916.1 MetaCyc: PWY-5523 5,6-dimethylbenzimidazole biosynthesis I (aerobic) 1 EFA06175.2 KEGG: 00051+5.4.2.8 Fructose and mannose metabolism 1 EFA07975.2 Reactome: R-HSA-6783984 Glycine degradation 7 KYB25872.1;EFA12932.2;EFA05357.1;KYB25871.1;KYB25902.1;KYB27323.1;EFA01173.1 MetaCyc: PWY-8043 Ophthalmate biosynthesis 3 EFA04528.1;EFA06494.1;EFA06495.2 MetaCyc: PWY-7726 (4Z,7Z,10Z,13Z,16Z)-docosapentaenoate biosynthesis (6-desaturase) 8 EFA04382.1;EFA08151.1;EFA05143.1;EFA09425.1;EFA11530.1;EFA03551.1;EFA09569.1;EFA05073.1 Reactome: R-HSA-9013695 NOTCH4 Intracellular Domain Regulates Transcription 4 EFA02517.2;EEZ99094.1;EFA04470.1;EEZ99435.2 Reactome: R-HSA-5696400 Dual Incision in GG-NER 30 EFA08916.1;KYB28926.1;KYB27483.1;EFA08812.2;EEZ97282.2;KYB29360.1;KYB25740.1;EFA12891.1;EFA09906.2;EFA00018.1;EFA02110.1;EFA02310.1;KYB25721.1;EFA07302.1;EFA06672.2;EFA03362.2;EFA00829.2;EFA02756.1;EFA03814.1;KYB26713.1;EFA03020.2;KYB28925.1;KYB25378.1;KYB29359.1;EFA12420.2;EFA03569.1;EFA07958.1;EFA09711.2;EFA00328.1;EFA06042.1 Reactome: R-HSA-201688 WNT mediated activation of DVL 1 EEZ97852.2 KEGG: 00330+2.6.1.13 Arginine and proline metabolism 1 EFA12217.1 MetaCyc: PWY-4061 Glutathione-mediated detoxification I 8 EFA08906.2;KYB26171.1;EFA08621.1;EEZ99480.1;EFA08560.1;EFA00963.1;EEZ99479.1;KYB26172.1 MetaCyc: PWY-7857 Adlupulone and adhumulone biosynthesis 2 EFA12019.1;EFA12933.2 KEGG: 00020+1.1.1.37 Citrate cycle (TCA cycle) 2 EFA04972.1;EFA02482.1 MetaCyc: PWY-5826 Hypoglycin biosynthesis 4 EFA08621.1;EFA08906.2;KYB26171.1;KYB26172.1 MetaCyc: PWY-7118 Chitin degradation to ethanol 3 EFA12019.1;EEZ98950.2;EFA12933.2 MetaCyc: PWY-5691 Urate conversion to allantoin I 3 EFA02262.1;KYB28295.1;EEZ99723.1 Reactome: R-HSA-446193 Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein 12 EFA00652.1;EFA05431.1;EEZ98644.1;EFA05490.1;EFA00490.1;EFA07754.1;KYB29165.1;EFA11523.2;EFA02198.2;KYB27827.1;EFA03871.1;EFA05255.1 Reactome: R-HSA-193692 Regulated proteolysis of p75NTR 7 EFA07178.2;EEZ98535.2;EFA02851.1;KYB27078.1;KYB29228.1;EFA04103.1;EFA05049.2 Reactome: R-HSA-8941332 RUNX2 regulates genes involved in cell migration 3 EFA03630.2;EFA02105.1;KYB27618.1 MetaCyc: PWY-6964 Ammonia assimilation cycle II 2 EEZ97848.1;EEZ99821.1 Reactome: R-HSA-73776 RNA Polymerase II Promoter Escape 30 EFA07031.1;EFA03759.1;EFA05897.1;KYB29038.1;EEZ97398.2;EFA00018.1;KYB28470.1;EEZ99738.1;EEZ97886.2;EFA06469.1;EFA07302.1;EFA07055.2;EFA02310.1;EFA03150.1;EFA03550.1;EFA11878.1;KYB26001.1;EFA06560.1;KYB25378.1;KYB29037.1;EFA05523.2;EFA05226.1;EFA02321.1;KYB25152.1;EFA00911.1;EFA05896.1;EFA03093.1;EFA00328.1;EFA03052.1;EFA06253.1 Reactome: R-HSA-2032785 YAP1- and WWTR1 (TAZ)-stimulated gene expression 1 KYB29367.1 Reactome: R-HSA-162699 Synthesis of dolichyl-phosphate mannose 2 EFA04846.1;EFA06224.2 KEGG: 00362+4.2.1.17+1.1.1.35 Benzoate degradation 3 EFA08151.1;EFA05073.1;EFA04382.1 MetaCyc: PWY-6580 Phosphatidylinositol biosynthesis I (bacteria) 1 EFA09280.1 Reactome: R-HSA-112126 ALKBH3 mediated reversal of alkylation damage 2 EFA08000.1;EFA04486.1 Reactome: R-HSA-429947 Deadenylation of mRNA 9 EFA07855.1;KYB28664.1;EEZ99555.2;KYB26978.1;EFA00624.1;EFA06281.1;EFA06380.2;EFA09006.2;EEZ99732.2 MetaCyc: PWY-6619 Adenine and adenosine salvage VI 4 EFA08050.1;EFA07316.1;KYB25745.1;KYB25746.1 Reactome: R-HSA-198753 ERK/MAPK targets 1 EFA10708.1 MetaCyc: PWY-5030 L-histidine degradation III 3 KYB26333.1;EFA07236.1;EFA07809.2 MetaCyc: PWY-6606 Guanosine nucleotides degradation II 3 EFA09973.1;EFA01792.1;EFA06106.1 Reactome: R-HSA-5693616 Presynaptic phase of homologous DNA pairing and strand exchange 25 EFA02865.1;KYB25740.1;EFA05681.1;EFA00407.2;EFA09906.2;EFA12891.1;EFA08916.1;EFA02866.1;EFA04568.2;KYB27777.1;KYB27483.1;EEZ97345.1;EEZ99558.2;EFA08981.1;KYB26388.1;EEZ97797.2;EFA09584.2;EFA02756.1;EFA11787.2;EFA13005.2;EFA04934.2;EFA09711.2;EFA12420.2;EFA07487.1;KYB25791.1 Reactome: R-HSA-5673000 RAF activation 6 KYB28360.1;EEZ99807.2;KYB26642.1;EFA05992.2;EFA05346.2;KYB26383.1 Reactome: R-HSA-4641257 Degradation of AXIN 41 KYB26545.1;EFA05912.1;KYB29359.1;EFA07110.1;EFA05833.1;EEZ99004.1;KYB24713.1;KYB25309.1;EFA04284.1;EFA05370.2;EEZ97564.1;EFA07261.2;EFA04054.1;EFA05865.1;EFA09524.2;EFA08798.1;EFA08601.1;EFA05871.2;EFA07659.2;EFA09518.2;EEZ98185.1;EFA02331.1;EFA09228.1;EFA03019.1;EFA05105.1;KYB27556.1;EEZ97876.1;KYB26764.1;EFA03341.1;EFA11079.1;EFA06519.1;EFA06741.1;EFA06200.1;EFA08664.1;EFA02110.1;KYB29360.1;KYB27557.1;EFA08911.2;EFA02345.1;EFA13218.1;EEZ99493.1 Reactome: R-HSA-6803529 FGFR2 alternative splicing 12 EFA05896.1;EEZ98143.1;EEZ98144.2;KYB26001.1;EEZ97398.2;EFA06560.1;EFA03550.1;EFA03150.1;EFA07031.1;KYB25152.1;KYB28470.1;EFA05226.1 MetaCyc: PWY-7117 C4 photosynthetic carbon assimilation cycle, PEPCK type 8 EFA11790.2;KYB27212.1;EFA03109.1;EFA04508.1;EEZ98484.1;EFA04122.1;KYB29101.1;EFA00432.1 Reactome: R-HSA-5610785 GLI3 is processed to GLI3R by the proteasome 42 EFA11079.1;EFA06519.1;EFA06741.1;EFA06200.1;EFA08664.1;EEZ97876.1;KYB27556.1;EFA02847.1;KYB26764.1;EFA03341.1;KYB29360.1;KYB27557.1;EFA08911.2;EFA02345.1;EFA13218.1;EEZ99493.1;EFA02110.1;KYB29272.1;EFA05833.1;EEZ99004.1;KYB24713.1;KYB25309.1;EFA04284.1;EFA05370.2;KYB26545.1;KYB29359.1;EFA05912.1;EFA07110.1;EFA08601.1;EFA05871.2;EFA07659.2;EFA09518.2;EFA02331.1;EEZ98185.1;EFA03019.1;EFA05105.1;EEZ97564.1;EFA07261.2;EFA05865.1;EFA04054.1;EFA09524.2;EFA08798.1 MetaCyc: PWY-7892 Trna-uridine 2-thiolation and selenation (bacteria) 1 EFA07642.2 Reactome: R-HSA-8931987 RUNX1 regulates estrogen receptor mediated transcription 2 EFA03630.2;KYB27618.1 MetaCyc: PWY-5966-1 Fatty acid biosynthesis initiation (animals and fungi, cytoplasm) 8 EEZ97866.2;EFA05436.2;EFA05201.1;EFA05249.2;EFA11365.1;EFA05248.1;EFA05203.2;EFA05204.2 Reactome: R-HSA-1660516 Synthesis of PIPs at the early endosome membrane 5 KYB26275.1;EFA00380.1;KYB26276.1;EEZ98191.1;EFA06197.2 Reactome: R-HSA-983168 Antigen processing: Ubiquitination & Proteasome degradation 139 EFA09518.2;KYB29890.1;EFA08601.1;EFA11345.1;EEZ98185.1;EFA02331.1;EEZ98497.1;EFA10928.1;EFA08997.2;EFA09680.1;EFA03940.2;KYB27620.1;EFA11317.1;KYB28908.1;EEZ98478.1;EFA07112.2;EFA00388.1;EFA01492.2;EFA07110.1;EFA03386.1;KYB24996.1;EFA02147.2;EFA07468.1;KYB25356.1;EEZ97760.2;EFA13218.1;KYB25932.1;EFA02110.1;EFA07520.2;EFA02057.1;KYB27699.1;EFA04064.1;EFA01434.1;EEZ97876.1;KYB27556.1;KYB29092.1;EFA03341.1;EFA00073.1;EFA07009.1;EEZ97189.1;EFA10984.1;EFA05871.2;EFA07659.2;EEZ97366.1;EFA03019.1;EEZ97459.2;EFA06131.1;EFA00304.1;KYB25931.1;KYB27271.1;EFA05865.1;EFA04054.1;EFA05833.1;EFA05370.2;EFA05319.1;KYB26545.1;EFA06902.2;EFA05912.1;KYB27557.1;EFA03872.2;KYB29360.1;EFA12146.1;EEZ97976.1;EFA02345.1;KYB24712.1;EFA06061.2;KYB27308.1;EFA09480.2;EEZ98737.1;EFA06519.1;EFA09828.2;EFA06200.1;KYB25930.1;EFA03490.1;EFA11491.1;EFA08807.2;EFA09707.1;EFA00158.1;EFA05105.1;EEZ97564.1;EFA01854.1;EEZ99272.2;KYB24713.1;EEZ99004.1;EFA09947.1;EFA01469.1;EFA00574.1;EFA04284.1;KYB25457.1;EFA06399.2;EFA01569.1;EFA04169.1;EFA02989.2;KYB27187.1;EFA09218.1;KYB29359.1;EEZ99493.1;EEZ99199.1;EFA08911.2;EFA03675.1;EEZ97989.1;EFA04231.1;EEZ97941.1;EEZ99453.2;EFA06528.1;KYB27535.1;EFA06741.1;EFA11079.1;EEZ99274.1;EFA01155.1;EEZ99808.2;KYB29735.1;EFA02847.1;KYB24961.1;KYB26439.1;EFA07261.2;EFA08798.1;EFA09524.2;EFA05194.1;EFA06125.1;EFA00121.1;EEZ99944.2;KYB25309.1;EFA11744.1;EFA04459.2;KYB25814.1;EFA05186.1;EFA04916.1;EFA08658.1;EFA01329.1;EFA13414.2;EEZ97228.2;EFA06019.1;EEZ97381.1;EFA08664.1;EEZ97210.1;EFA01832.1;EFA11211.1;KYB26764.1 Reactome: R-HSA-5651801 PCNA-Dependent Long Patch Base Excision Repair 22 KYB26857.1;EFA06383.1;KXZ75899.1;EFA02756.1;EFA03814.1;KYB26713.1;EFA03020.2;KYB28925.1;EFA12420.2;EFA07958.1;EFA09711.2;EFA06042.1;EFA08916.1;KYB28926.1;KYB27483.1;EFA08812.2;KYB25740.1;EFA09906.2;EFA12891.1;KYB25721.1;EFA12889.2;EFA06672.2 Reactome: R-HSA-9020702 Interleukin-1 signaling 46 EFA08798.1;EFA09524.2;EFA04054.1;EFA05865.1;EFA07261.2;EEZ97564.1;EFA05105.1;EFA03019.1;EFA02331.1;EEZ98185.1;EFA09518.2;EFA07659.2;EFA05871.2;EFA08601.1;EFA01304.1;EFA07110.1;KYB29359.1;EFA05912.1;KYB26545.1;EFA05370.2;EFA04284.1;KYB25309.1;KYB24713.1;EFA05833.1;EEZ99004.1;EFA02110.1;EEZ99493.1;EFA02345.1;EFA13218.1;EFA08911.2;KYB27557.1;EFA02851.1;KYB29360.1;EFA03341.1;KYB26671.1;KYB26764.1;EFA02847.1;EEZ97876.1;KYB27556.1;EFA01564.1;KYB26669.1;EFA08664.1;EFA06200.1;EFA06741.1;EFA06519.1;EFA11079.1 KEGG: 00230+2.7.6.1 Purine metabolism 2 EFA00168.2;EFA07775.1 KEGG: 00261+2.7.7.4 Monobactam biosynthesis 1 EFA13134.1 KEGG: 00900+2.1.1.100 Terpenoid backbone biosynthesis 1 EFA03159.1 Reactome: R-HSA-1483152 Hydrolysis of LPE 2 EFA03495.2;KYB27179.1 MetaCyc: PWY-6871 3-methylbutanol biosynthesis (engineered) 1 EEZ98950.2 Reactome: R-HSA-2408557 Selenocysteine synthesis 75 EEZ98728.1;EFA01731.1;EFA09067.1;EFA13254.1;EFA09212.1;EFA08624.1;EFA06341.1;KYB27567.1;EFA06574.1;KYB29359.1;EFA04453.1;EFA02145.1;EFA06534.1;EFA05170.2;EEZ97379.1;EFA03346.1;EFA02268.1;EEZ99099.1;EFA07141.1;EFA04946.1;EFA02110.1;EFA11837.1;EFA00505.1;EFA08168.1;EFA08849.1;EFA06843.2;EFA07030.1;EFA01805.1;EFA05867.1;EFA03533.1;EFA02992.1;EEZ97412.1;EFA00935.2;EFA10201.2;EFA06382.1;EEZ97313.1;EFA08054.1;EFA12204.1;KYB27481.1;EEZ97645.1;EFA01051.1;EFA02554.1;EFA09390.1;EFA10969.1;EFA07317.1;EEZ98852.1;EFA03166.1;EFA05471.1;EFA04120.1;EFA00163.1;EFA03478.1;EFA09345.2;EFA03441.1;EEZ98858.1;EEZ98503.1;KYB27741.1;EFA03236.1;EFA11360.1;EFA02257.1;EFA10462.1;EFA05803.1;KYB29360.1;EFA10173.2;EFA02592.1;EFA01765.1;EFA10183.1;EEZ97360.2;KYB26424.1;KYB27801.1;EFA11293.1;EFA04159.1;EFA09970.1;KYB29621.1;EEZ99023.1;EFA05373.1 Reactome: R-HSA-983170 Antigen Presentation: Folding, assembly and peptide loading of class I MHC 5 EEZ98819.2;KYB24587.1;EFA01820.1;EFA06320.2;KYB26644.1 Reactome: R-HSA-6782135 Dual incision in TC-NER 44 EFA00328.1;EFA06042.1;KYB29359.1;EFA03569.1;EFA05896.1;KYB28925.1;KYB26713.1;EFA03020.2;EFA02756.1;EFA03814.1;EFA06560.1;KYB26824.1;EFA07302.1;EFA07055.2;EFA02310.1;KYB25721.1;EFA09906.2;KYB26826.1;KYB25740.1;EFA06469.1;KYB28926.1;KYB27483.1;EFA08812.2;EFA08916.1;EFA09711.2;EFA07958.1;EFA07762.1;KYB25334.1;EFA12420.2;EFA12724.1;KYB25378.1;EFA05226.1;EFA03150.1;KYB26001.1;EFA03362.2;EFA06672.2;EFA02110.1;EFA12891.1;KYB28470.1;EFA00018.1;EEZ97282.2;KYB29360.1;EFA07031.1;EFA10422.1 Reactome: R-HSA-8949613 Cristae formation 20 EEZ98080.1;EFA07467.2;EFA11746.1;EFA09167.1;EFA07381.1;EFA04639.1;EFA07448.1;EFA04496.1;EFA05714.1;EFA07499.1;EFA04019.2;EEZ97751.1;EFA01349.1;EEZ99347.1;EFA07428.1;EFA07449.2;EFA12946.2;EEZ99200.1;KYB27071.1;EFA10485.1 MetaCyc: PWY-7230 Ubiquinol-6 biosynthesis from 4-aminobenzoate (yeast) 2 KYB26214.1;EFA04400.1 Reactome: R-HSA-5250924 B-WICH complex positively regulates rRNA expression 13 EFA04470.1;EFA07284.1;KYB26001.1;KYB24563.1;EFA05514.1;EFA03150.1;EFA07031.1;KYB28470.1;EFA05896.1;KYB26622.1;EFA08638.2;EEZ99110.1;KYB25540.1 KEGG: 00030+3.1.1.31 Pentose phosphate pathway 1 EFA08071.1 Reactome: R-HSA-5339700 TCF7L2 mutants don't bind CTBP 1 EFA10253.2 KEGG: 00785+2.8.1.8 Lipoic acid metabolism 1 EFA02475.1 Reactome: R-HSA-445095 Interaction between L1 and Ankyrins 13 KYB28285.1;EFA01607.2;KYB28283.1;EFA11577.2;KYB28367.1;KYB29592.1;EFA05958.2;KYB28369.1;KYB28368.1;KYB28284.1;EEZ99233.1;KYB28281.1;KYB29593.1 KEGG: 00630+6.3.1.2 Glyoxylate and dicarboxylate metabolism 2 EEZ99821.1;EEZ97848.1 MetaCyc: PWY-6118 Glycerol-3-phosphate shuttle 5 KYB29133.1;KYB27335.1;EEZ98249.2;EFA04316.2;KYB29132.1 Reactome: R-HSA-8957275 Post-translational protein phosphorylation 14 KYB29706.1;EEZ98119.2;EEZ98657.1;KYB29705.1;EFA02211.1;KYB28740.1;KYB26997.1;EFA00011.2;KYB29704.1;EFA07880.1;EFA11302.1;EFA07881.1;EFA10125.2;EFA11425.1 Reactome: R-HSA-110381 Resolution of AP sites via the single-nucleotide replacement pathway 2 KYB29442.1;EEZ98905.1 Reactome: R-HSA-8963888 Chylomicron assembly 8 EFA11425.1;EFA08014.1;EFA11302.1;EFA03647.1;KYB26997.1;KYB29704.1;KYB29705.1;KYB29706.1 KEGG: 00790+2.8.1.9 Folate biosynthesis 1 EEZ98196.1 KEGG: 00500+3.2.1.28 Starch and sucrose metabolism 6 EFA08992.1;EFA08991.1;EFA08993.1;EFA11183.1;EFA11727.2;EFA08990.1 Reactome: R-HSA-399956 CRMPs in Sema3A signaling 1 EFA11336.2 KEGG: 00562+3.1.3.36 Inositol phosphate metabolism 2 EFA11114.1;EFA09929.2 MetaCyc: PWY-561 Superpathway of glyoxylate cycle and fatty acid degradation 7 EFA02829.1;EFA10709.2;EFA03144.1;EFA02482.1;EFA04683.1;EFA04972.1;EFA09226.1 MetaCyc: PWY-6902 Chitin degradation II (Vibrio) 30 EFA06863.2;EFA07069.1;EFA06695.1;EFA05323.2;EFA05960.2;EFA06923.1;EEZ98597.1;EFA10268.1;EFA08995.1;EFA06698.1;EFA06311.1;EFA06694.1;KYB25657.1;EFA06307.1;EFA05959.1;EFA11380.2;EFA10939.1;KYB26649.1;EFA06696.2;EFA10488.1;EFA06693.1;KYB26650.1;EFA06310.1;EFA00965.2;EFA06836.2;EFA05481.2;EFA06308.1;KYB26651.1;EFA06699.2;EFA06309.1 Reactome: R-HSA-2142700 Synthesis of Lipoxins (LX) 3 KYB26848.1;EFA06407.2;EFA06410.1 KEGG: 00521+5.5.1.4 Streptomycin biosynthesis 1 EFA09280.1 Reactome: R-HSA-9619483 Activation of AMPK downstream of NMDARs 14 EFA04833.1;EFA09822.2;EFA02004.1;EEZ97891.1;EFA07410.1;EFA11292.1;EEZ97229.1;EFA06187.1;EEZ99331.1;EEZ99070.2;KYB26929.1;EFA06663.1;KYB26625.1;EEZ99348.1 KEGG: 00561+2.3.1.15 Glycerolipid metabolism 2 EFA06119.2;EFA09975.1 Reactome: R-HSA-3772470 Negative regulation of TCF-dependent signaling by WNT ligand antagonists 1 EFA13018.1 KEGG: 00270+2.5.1.6 Cysteine and methionine metabolism 1 EEZ97278.1 KEGG: 00983+3.6.1.23 Drug metabolism - other enzymes 1 EFA05862.1 Reactome: R-HSA-388844 Receptor-type tyrosine-protein phosphatases 5 KYB29539.1;KYB28051.1;EEZ99137.2;KYB29537.1;KYB29538.1 KEGG: 00860+2.5.1.61 Porphyrin and chlorophyll metabolism 1 EFA03098.1 Reactome: R-HSA-210990 PECAM1 interactions 1 EFA12064.1 Reactome: R-HSA-77387 Insulin receptor recycling 23 KYB29411.1;EFA11012.1;EEZ99208.1;KYB28989.1;KYB29412.1;EFA02241.1;EFA08618.1;EFA03371.1;EFA06225.1;EFA01142.2;EFA02476.1;KYB29410.1;EFA05894.1;EEZ99071.2;EEZ98406.2;EFA06700.2;EFA10717.1;EFA02242.2;KYB29409.1;EEZ98813.2;EFA02908.1;KYB29413.1;EEZ97227.1 Reactome: R-HSA-6802946 Signaling by moderate kinase activity BRAF mutants 6 EFA05346.2;KYB26173.1;EFA10708.1;EEZ99807.2;KYB28360.1;EFA08276.1 Reactome: R-HSA-975110 TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling 5 EFA01304.1;KYB29359.1;EFA02110.1;EFA02851.1;KYB29360.1 KEGG: 00970+6.1.1.14 Aminoacyl-tRNA biosynthesis 2 EFA03680.2;KYB27572.1 MetaCyc: PWY-7112 4-hydroxy-2-nonenal detoxification 8 EFA08621.1;KYB26171.1;EFA08906.2;EEZ99480.1;EFA08560.1;EFA00963.1;KYB26172.1;EEZ99479.1 Reactome: R-HSA-6785470 tRNA processing in the mitochondrion 3 EFA06191.2;EFA09019.1;EFA01836.2 Reactome: R-HSA-8941333 RUNX2 regulates genes involved in differentiation of myeloid cells 2 KYB27618.1;EFA03630.2 Reactome: R-HSA-3214841 PKMTs methylate histone lysines 17 EFA01589.2;EFA00645.1;KYB29375.1;EFA04076.1;EFA02617.1;EFA05577.2;EFA11580.2;KYB24563.1;KYB26074.1;EFA05618.2;KYB29184.1;EEZ98177.2;EFA08462.2;EFA11417.2;EEZ97316.2;EEZ98588.1;EFA10454.1 Reactome: R-HSA-937039 IRAK1 recruits IKK complex 6 EFA02851.1;KYB29360.1;EFA02110.1;KYB29359.1;KYB26671.1;KYB26669.1 Reactome: R-HSA-444257 RSK activation 4 KYB29263.1;EEZ98563.1;EFA10708.1;EFA00152.1 Reactome: R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK 13 EFA09095.1;EFA03068.1;EFA04319.1;EFA09042.2;EFA00138.1;EFA02004.1;EEZ99978.2;EFA07410.1;EFA02668.2;EFA12722.1;EFA07964.1;EFA08847.1;EFA10720.1 MetaCyc: PWY-6837 Fatty acid beta-oxidation V (unsaturated, odd number, di-isomerase-dependent) 3 EFA09569.1;EFA09425.1;EFA11530.1 KEGG: 00270+5.3.1.23 Cysteine and methionine metabolism 4 EEZ97197.1;EFA12349.2;EFA12261.1;EFA02518.1 MetaCyc: PWY-6908 Thiamine diphosphate biosynthesis IV (eukaryotes) 2 KYB29167.1;EEZ98443.2 Reactome: R-HSA-69205 G1/S-Specific Transcription 12 EFA02095.1;EFA04623.2;EFA03095.1;EFA06042.1;EFA00549.1;EFA11748.1;EFA07671.2;EFA08856.2;EFA01741.1;EFA05648.1;EFA06047.1;EFA02434.1 Reactome: R-HSA-202670 ERKs are inactivated 1 EFA10708.1 Reactome: R-HSA-975138 TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation 3 EFA01304.1;EFA02851.1;EFA07356.1 MetaCyc: PWY-5744 Glyoxylate assimilation 8 EFA11790.2;EFA07129.2;EFA03586.1;EFA04508.1;EEZ98484.1;EFA05436.2;KYB29101.1;EFA00432.1 KEGG: 00230+2.7.7.4 Purine metabolism 1 EFA13134.1 Reactome: R-HSA-5632681 Ligand-receptor interactions 1 KYB28973.1 KEGG: 00052+2.7.1.11 Galactose metabolism 2 EFA08228.2;KYB26002.1 Reactome: R-HSA-8963901 Chylomicron remodeling 6 KYB29705.1;KYB29706.1;EFA11302.1;KYB26997.1;EFA11425.1;KYB29704.1 MetaCyc: PWY-6344 L-ornithine degradation II (Stickland reaction) 4 EFA12217.1;EEZ98116.1;EEZ98115.1;EFA00672.1 Reactome: R-HSA-8964026 Chylomicron clearance 6 EFA11425.1;KYB26997.1;KYB29704.1;KYB29705.1;EFA11302.1;KYB29706.1 Reactome: R-HSA-425393 Transport of inorganic cations/anions and amino acids/oligopeptides 1 EFA10650.1 KEGG: 00670+1.5.1.6 One carbon pool by folate 1 EFA05437.1 KEGG: 00010+2.7.1.40 Glycolysis / Gluconeogenesis 7 KYB24934.1;EFA08832.2;EEZ97193.2;KYB25941.1;EEZ99016.2;EFA08842.1;KYB24935.1 KEGG: 00270+2.5.1.16 Cysteine and methionine metabolism 2 EFA05567.1;EFA05082.1 KEGG: 00030+4.1.2.13 Pentose phosphate pathway 1 EFA04932.1 Reactome: R-HSA-197264 Nicotinamide salvaging 4 EFA10857.2;EFA11311.2;EFA02619.2;EEZ97420.1 Reactome: R-HSA-982772 Growth hormone receptor signaling 5 EFA10708.1;KYB29228.1;EFA05273.2;KYB27132.1;EEZ98535.2 Reactome: R-HSA-1614603 Cysteine formation from homocysteine 2 KYB26716.1;EFA10345.1 MetaCyc: PWY-6168 Flavin biosynthesis III (fungi) 1 EFA06175.2 Reactome: R-HSA-5358751 S45 mutants of beta-catenin aren't phosphorylated 4 EFA13272.2;KYB26642.1;KYB26383.1;EFA05992.2 Reactome: R-HSA-1236382 Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants 4 EFA03198.1;KYB29359.1;EFA02110.1;KYB29360.1 MetaCyc: PWY-6019 Pseudouridine degradation 1 EFA03366.1 MetaCyc: PWY-7589 Palmitoleate biosynthesis III (cyanobacteria) 6 EFA02132.1;KYB27110.1;EEZ97656.1;EEZ97257.1;KYB27111.1;EFA04525.1 Reactome: R-HSA-8868766 rRNA processing in the mitochondrion 2 EFA01836.2;EFA09019.1 Reactome: R-HSA-8943724 Regulation of PTEN gene transcription 14 EFA07964.1;EFA10731.1;EFA12722.1;EFA04088.1;EFA08847.1;EFA10708.1;EFA06839.2;EFA06006.1;EFA03068.1;EFA09095.1;KYB26273.1;EFA00645.1;EEZ99978.2;EFA02668.2 KEGG: 00250+2.6.1.1 Alanine, aspartate and glutamate metabolism 3 EFA04122.1;KYB27212.1;EFA03109.1 Reactome: R-HSA-389957 Prefoldin mediated transfer of substrate to CCT/TriC 14 EEZ99111.1;EFA02141.1;EEZ98476.1;EFA02100.1;EFA09930.1;EEZ97857.1;EFA06459.1;EEZ97967.1;EEZ99517.1;EEZ97405.1;EEZ98562.1;EEZ98584.1;EFA05810.1;EFA01203.1 Reactome: R-HSA-5368286 Mitochondrial translation initiation 62 EFA02562.2;KYB29131.1;KYB24820.1;EFA02162.2;KYB27088.1;EFA03392.1;EFA10018.1;KYB28774.1;KYB27767.1;EFA06988.1;EFA07649.2;EEZ97275.1;KYB26858.1;KYB28841.1;EEZ98800.1;EFA06635.1;EFA08827.1;KYB26787.1;EFA04432.1;EEZ98405.2;KYB28924.1;EFA03754.1;EFA00783.1;KYB29057.1;EFA06934.1;EFA07359.2;EFA08204.1;EFA01516.1;EFA00128.1;EFA07686.2;KYB25660.1;EFA01882.1;KYB29134.1;EEZ98621.2;EFA07911.1;EFA00920.1;EFA07281.1;EFA09638.1;EFA06593.1;EEZ98314.1;EFA02474.1;EFA07822.2;EFA04074.1;EFA01965.1;EFA10137.1;EFA08795.1;KYB28074.1;KYB29135.1;EFA03160.1;EFA10545.1;EEZ99502.1;EFA11361.1;KYB29220.1;EFA12135.2;EFA07188.1;EFA03148.1;EFA00323.1;EFA02054.1;EFA08456.1;EFA04077.1;KYB26079.1;EFA13662.2 MetaCyc: PWY-5109 Fermentation to 2-methylbutanoate 3 EFA08151.1;EFA05073.1;EFA04382.1 KEGG: 00950+2.6.1.1 Isoquinoline alkaloid biosynthesis 3 KYB27212.1;EFA04122.1;EFA03109.1 KEGG: 00980+2.5.1.18 Metabolism of xenobiotics by cytochrome P450 4 EFA08560.1;EEZ99479.1;EEZ99480.1;EFA00963.1 Reactome: R-HSA-8853659 RET signaling 3 KYB29656.1;EFA11039.2;KYB29693.1 Reactome: R-HSA-6802955 Paradoxical activation of RAF signaling by kinase inactive BRAF 6 KYB28360.1;EFA08276.1;KYB26173.1;EFA10708.1;EEZ99807.2;EFA05346.2 KEGG: 00510+2.4.1.131 N-Glycan biosynthesis 1 EFA05431.1 KEGG: 04150+2.7.11.1 mTOR signaling pathway 55 KYB27979.1;KYB28376.1;KYB28375.1;KYB28377.1;EFA01876.2;EFA08276.1;EFA10048.1;EFA00152.1;EFA10912.2;EFA07752.1;EFA11394.1;EFA08636.2;EFA00769.1;EFA04406.2;EFA10720.1;KYB25791.1;EFA03058.1;EFA02105.1;EEZ98574.2;EFA07964.1;KYB29873.1;EFA11787.2;EEZ97987.1;EFA02342.2;KYB28837.1;EFA07410.1;KYB28437.1;KYB27138.1;EFA05720.1;EEZ99828.2;KYB27978.1;EFA11184.1;KYB28836.1;KYB29263.1;EEZ99162.2;KYB28439.1;EFA11019.1;EFA07902.1;EFA02123.1;EFA04100.2;KYB25762.1;KYB27402.1;EFA13584.2;EEZ98563.1;KYB28438.1;KYB28374.1;EFA08613.1;EFA11391.2;EFA00691.2;EFA00476.1;EFA00805.1;EFA05002.2;KYB27919.1;EFA06330.1;KYB26173.1 Reactome: R-HSA-2132295 MHC class II antigen presentation 66 EFA04570.1;KYB26625.1;KYB25071.1;EFA07519.1;EFA05000.1;EFA01735.1;EFA13374.1;EFA11263.1;KYB26929.1;EEZ99348.1;EFA06320.2;EFA11142.1;EFA09203.1;EFA07493.2;EEZ97693.1;EFA02812.2;EEZ97809.1;EFA09822.2;EFA07481.2;KYB26820.1;KYB24587.1;EFA06474.1;EFA09154.2;KYB26644.1;EFA06663.1;EFA09153.1;EEZ97810.1;EFA01283.1;EEZ97229.1;EEZ97696.1;EFA06446.1;EFA01288.1;EFA01820.1;EFA11292.1;EFA04833.1;KYB26892.1;KYB26628.1;KYB25072.1;KYB28975.1;EFA06187.1;EEZ99331.1;EFA09781.1;KYB28573.1;EFA07489.1;EFA11596.1;EFA01287.1;EFA09381.2;EEZ99070.2;EFA10255.2;EEZ97694.1;KYB24980.1;EFA09206.2;EFA01289.1;EEZ97487.2;KYB28974.1;EFA01286.1;EEZ97891.1;EFA07480.1;EFA07482.1;EEZ97538.1;KYB26629.1;EFA04983.2;KYB25597.1;EFA02324.2;EFA09305.2;EFA03783.1 KEGG: 00860+4.4.1.17 Porphyrin and chlorophyll metabolism 1 EFA09605.1 MetaCyc: PWY-6683 Assimilatory sulfate reduction III 1 EFA13134.1 Reactome: R-HSA-428930 Thromboxane signalling through TP receptor 3 EEZ98203.2;KYB25864.1;KYB29172.1 KEGG: 00524+2.7.1.1 Neomycin, kanamycin and gentamicin biosynthesis 4 KYB29371.1;EEZ97932.2;KYB29370.1;EEZ97931.1 MetaCyc: PWY-7102 Bisabolene biosynthesis (engineered) 1 EFA07280.1 Reactome: R-HSA-399997 Acetylcholine regulates insulin secretion 3 EEZ98203.2;KYB27786.1;KYB29172.1 MetaCyc: PWY-7546 Diphthamide biosynthesis II (eukaryotes) 3 EFA02050.1;EEZ99477.1;EFA05560.1 KEGG: 00980+1.14.14.1 Metabolism of xenobiotics by cytochrome P450 1 EFA05733.1 KEGG: 00600+2.4.1.80 Sphingolipid metabolism 1 EFA12048.1 Reactome: R-HSA-1236978 Cross-presentation of soluble exogenous antigens (endosomes) 37 EFA03341.1;KYB26764.1;KYB27556.1;EEZ97876.1;EFA06200.1;EFA08664.1;EFA06519.1;EFA11079.1;EFA06741.1;EFA02345.1;EFA13218.1;EFA08911.2;EEZ99493.1;KYB27557.1;EFA05912.1;EFA07110.1;KYB26545.1;KYB25309.1;EFA04284.1;EFA05370.2;KYB24713.1;EFA05833.1;EEZ99004.1;EFA04054.1;EFA05865.1;EFA08798.1;EFA09524.2;EFA07261.2;EEZ97564.1;EFA02331.1;EEZ98185.1;EFA05105.1;EFA03019.1;EFA08601.1;EFA09518.2;EFA07659.2;EFA05871.2 Reactome: R-HSA-72187 mRNA 3'-end processing 27 KYB26428.1;EFA12271.1;EFA11869.1;EEZ97191.2;EEZ98316.2;EFA08132.1;EFA09426.1;EEZ98143.1;EEZ98144.2;EFA07272.1;KYB29603.1;EFA03141.1;EFA11531.2;EFA08780.1;EFA09827.1;EFA01592.2;EFA05604.1;EFA10607.2;EFA07957.1;KYB26686.1;EFA08116.2;EFA12938.2;EEZ97980.2;EFA02993.1;EFA07541.2;KYB27333.1;KYB26337.1 MetaCyc: PWY-7220 Adenosine deoxyribonucleotides de novo biosynthesis II 8 EEZ98594.1;KYB26165.1;EFA07171.1;EFA02202.1;EFA02203.1;EFA03825.1;EEZ99726.1;EFA03917.1 Reactome: R-HSA-167242 Abortive elongation of HIV-1 transcript in the absence of Tat 20 KYB28470.1;EFA00603.1;EFA00606.1;EFA07031.1;EEZ97398.2;EEZ98143.1;EEZ98144.2;EFA10288.1;EFA05226.1;KYB25152.1;EFA08590.1;EFA03550.1;EFA03150.1;KYB26001.1;EFA06560.1;EFA00397.1;EFA07148.1;KYB25207.1;EFA05896.1;EFA05446.1 MetaCyc: PWY-6368 3-phosphoinositide degradation 3 EFA01248.1;EFA09929.2;EFA11114.1 MetaCyc: PWY-6999 Theophylline degradation 1 EFA09973.1 Reactome: R-HSA-174113 SCF-beta-TrCP mediated degradation of Emi1 41 EFA08664.1;EFA06200.1;EFA06741.1;EFA11079.1;EFA06519.1;KYB26764.1;EFA03341.1;EFA02847.1;EEZ97876.1;KYB27556.1;EEZ99493.1;EFA08911.2;EFA13218.1;EFA02345.1;KYB27557.1;KYB29360.1;EFA02110.1;EFA05370.2;EFA04284.1;KYB25309.1;EFA05833.1;EEZ99004.1;KYB24713.1;EFA07110.1;EFA05912.1;KYB29359.1;KYB26545.1;EFA03019.1;EFA05105.1;EFA02331.1;EEZ98185.1;EFA07659.2;EFA05871.2;EFA09518.2;EFA08601.1;EFA09524.2;EFA08798.1;EFA05865.1;EFA04054.1;EEZ97564.1;EFA07261.2 KEGG: 00250+1.4.1.14 Alanine, aspartate and glutamate metabolism 1 EFA03092.1 KEGG: 00630+2.1.2.1 Glyoxylate and dicarboxylate metabolism 1 EFA09131.1 Reactome: R-HSA-2408508 Metabolism of ingested SeMet, Sec, MeSec into H2Se 3 EFA10345.1;EFA04003.1;EFA02248.1 Reactome: R-HSA-380994 ATF4 activates genes in response to endoplasmic reticulum stress 15 EFA01958.1;EFA07836.1;EEZ98806.1;EFA07855.1;EEZ99918.1;EFA07181.2;KYB27475.1;EFA01850.1;EFA05246.1;EFA06035.2;EFA02571.1;EFA09953.1;EFA06447.1;EFA06999.1;EEZ97803.1 Reactome: R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER) 23 EFA05226.1;KYB25378.1;EFA06560.1;KYB26001.1;EFA03150.1;EFA07762.1;EFA00328.1;EFA05896.1;EFA12724.1;KYB29359.1;KYB25334.1;EFA06469.1;KYB29360.1;KYB26826.1;KYB28470.1;EFA00018.1;EFA10422.1;EFA07031.1;KYB26824.1;EFA02310.1;EFA02110.1;EFA07055.2;EFA07302.1 KEGG: 00564+2.7.7.41 Glycerophospholipid metabolism 3 EFA04759.2;EFA04441.1;EFA03942.2 MetaCyc: PWY-6146 Methanobacterium thermoautotrophicum biosynthetic metabolism 1 KYB27787.1 Reactome: R-HSA-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest 2 EFA10996.1;EFA06042.1 Reactome: R-HSA-6803207 TP53 Regulates Transcription of Caspase Activators and Caspases 4 EFA12881.2;EFA12882.1;EFA11787.2;EEZ98372.1 KEGG: 00600+3.2.1.45 Sphingolipid metabolism 1 EFA07388.1 KEGG: 00220+3.5.3.1 Arginine biosynthesis 1 EFA03145.1 MetaCyc: PWY-7734 Quinoxaline-2-carboxylate biosynthesis 1 KYB25672.1 Reactome: R-HSA-5579026 Defective CYP11A1 causes Adrenal insufficiency, congenital, with 46,XY sex reversal (AICSR) 3 EEZ97678.1;EEZ98188.2;EFA04921.1 MetaCyc: PWY-6313 Serotonin degradation 1 EEZ98950.2 KEGG: 00790+2.8.1.12 Folate biosynthesis 1 EFA06321.2 Reactome: R-HSA-211999 CYP2E1 reactions 1 KYB25634.1 Reactome: R-HSA-8943723 Regulation of PTEN mRNA translation 7 EFA11590.1;EFA09197.2;KYB25778.1;KYB26000.1;EFA08972.2;KYB25999.1;EFA04626.2 KEGG: 00270+3.3.1.1 Cysteine and methionine metabolism 2 EFA12023.2;EFA04274.1 KEGG: 00983+2.4.2.3 Drug metabolism - other enzymes 2 EEZ98937.1;EEZ98936.1 MetaCyc: PWY-7854 Crotonyl-coa/ethylmalonyl-coa/hydroxybutyryl-coa cycle (engineered) 3 EFA09425.1;EFA11530.1;EFA09569.1 Reactome: R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane 98 EFA09345.2;EFA03441.1;EEZ97812.1;EFA03478.1;EEZ98503.1;KYB27741.1;EFA00653.1;EEZ98858.1;EFA10929.1;EFA10462.1;EFA03236.1;EFA11360.1;EFA02257.1;EFA11223.1;EFA01706.1;EFA01765.1;EFA10183.1;EEZ97360.2;EFA05803.1;EFA02592.1;KYB29360.1;EFA10173.2;EFA04159.1;KYB27801.1;KYB26424.1;EFA11293.1;KYB29621.1;EFA09970.1;EFA05373.1;EEZ99023.1;KYB25734.1;KYB27481.1;EEZ97645.1;EFA12204.1;EFA02554.1;EFA01051.1;EFA09390.1;EFA07317.1;EEZ98852.1;EFA03166.1;EFA03003.1;EFA10969.1;EFA05471.1;EFA04120.1;EFA10002.1;EFA00163.1;EEZ99794.1;KYB25413.1;EFA11837.1;EFA10591.1;EFA09462.2;EFA07651.2;EFA02110.1;EFA00505.1;EEZ98192.1;EFA08849.1;EFA08168.1;EFA02325.1;EFA02397.1;EFA01805.1;EFA05867.1;EFA07030.1;EFA03379.1;EFA02992.1;EFA03533.1;EFA10201.2;EEZ97313.1;EFA11879.1;EFA06382.1;EEZ97412.1;EFA00935.2;EFA08054.1;EFA01731.1;EEZ98728.1;EFA09067.1;EFA13254.1;EFA06341.1;EFA08624.1;EFA10957.1;EFA09212.1;EEZ98538.1;KYB27567.1;EFA06574.1;EFA02145.1;EFA04453.1;EFA01427.1;KYB29359.1;EFA06534.1;EFA05170.2;EEZ97379.1;EFA03199.1;EEZ99099.1;EFA02268.1;EFA03346.1;EFA04946.1;EFA07141.1;EFA07146.1;EFA01230.1 MetaCyc: PWY-8049 Pederin biosynthesis 7 EEZ97866.2;EFA11365.1;EFA05248.1;EFA05203.2;EFA05204.2;EFA05201.1;EFA05249.2 Reactome: R-HSA-198693 AKT phosphorylates targets in the nucleus 1 EFA02105.1 KEGG: 00983+2.7.1.48 Drug metabolism - other enzymes 3 EFA11381.2;EEZ97798.2;KYB28983.1 Reactome: R-HSA-2022090 Assembly of collagen fibrils and other multimeric structures 11 EFA01286.1;KYB27188.1;KYB25044.1;EFA09153.1;EFA01289.1;EFA01287.1;EFA04342.1;EFA04092.2;EFA09154.2;EFA00883.1;EFA01288.1 Reactome: R-HSA-70688 Proline catabolism 2 EFA08381.1;EFA05239.1 Reactome: R-HSA-5358752 T41 mutants of beta-catenin aren't phosphorylated 4 KYB26383.1;EFA05992.2;EFA13272.2;KYB26642.1 MetaCyc: PWY-5686 UMP biosynthesis I 3 EEZ97344.2;EFA10197.1;EFA01834.2 MetaCyc: PWY-5 Canavanine biosynthesis 2 EFA11668.2;EEZ97516.1 MetaCyc: PWY-7606 Docosahexaenoate biosynthesis III (6-desaturase, mammals) 8 EFA05073.1;EFA09569.1;EFA03551.1;EFA09425.1;EFA11530.1;EFA08151.1;EFA05143.1;EFA04382.1 KEGG: 00600+3.1.4.12 Sphingolipid metabolism 1 EFA10294.2 KEGG: 04070+3.1.4.11 Phosphatidylinositol signaling system 7 KXZ75916.1;EFA12319.2;KYB28994.1;KYB27925.1;KYB27786.1;KXZ75917.1;KYB28995.1 Reactome: R-HSA-168276 NS1 Mediated Effects on Host Pathways 22 EFA01782.2;EFA01249.2;EFA03859.1;KYB28401.1;EFA07823.1;KYB29271.1;KYB29364.1;EFA04928.2;EEZ98695.2;KYB28630.1;EFA00605.1;EFA05993.1;EEZ98471.1;EFA09537.1;EFA11141.2;EEZ98092.1;KYB29624.1;EEZ97868.2;EFA11447.2;EFA04216.2;EFA03584.1;EFA00581.2 Reactome: R-HSA-6793080 rRNA modification in the mitochondrion 2 EFA10621.1;EFA11369.2 KEGG: 00565+3.1.4.4 Ether lipid metabolism 2 KYB27775.1;EFA02113.2 KEGG: 00790+6.3.2.17 Folate biosynthesis 1 EEZ98122.1 MetaCyc: PWY-7888 Trna-uridine 2-thiolation (cytoplasmic) 1 EFA02043.1 KEGG: 00250+4.3.2.1 Alanine, aspartate and glutamate metabolism 1 EFA11668.2 Reactome: R-HSA-5683826 Surfactant metabolism 3 EFA00339.1;EFA07318.1;EFA00425.1 Reactome: R-HSA-427413 NoRC negatively regulates rRNA expression 23 EFA07284.1;KYB24563.1;EFA07031.1;EFA03829.2;EFA02267.1;EFA06469.1;KYB28470.1;EFA00018.1;KYB26622.1;EFA00846.1;EFA07055.2;EFA02310.1;EFA07302.1;EFA08638.2;EEZ99110.1;EEZ97816.1;KYB26001.1;EFA03150.1;EFA06431.1;KYB25378.1;EFA05896.1;EFA00328.1;KYB29654.1 Reactome: R-HSA-209543 p75NTR recruits signalling complexes 5 EFA01304.1;EFA02110.1;KYB29359.1;KYB29360.1;EFA02851.1 MetaCyc: PWY-4261 Glycerol degradation I 8 KYB27335.1;EEZ98930.1;EFA09750.1;EEZ99630.1;EFA00308.1;EFA06784.1;EFA04316.2;EEZ99510.1 Reactome: R-HSA-9640463 Wax biosynthesis 28 EFA05205.1;EEZ99525.1;EFA08473.1;EFA07221.2;EFA05564.2;EFA05024.1;EEZ97452.1;EFA08449.1;EFA05233.2;KYB26083.1;KYB27109.1;EFA04974.1;EFA13305.2;EFA05234.1;EFA06842.1;EFA04917.2;EFA08470.2;EFA06888.2;EFA04973.1;EFA05235.1;KYB26690.1;EEZ97388.1;EFA08474.2;EFA05404.1;KYB26274.1;EFA05103.1;EFA06889.2;EFA05090.1 Reactome: R-HSA-5140745 WNT5A-dependent internalization of FZD2, FZD5 and ROR2 3 EFA11263.1;EFA09781.1;EFA02270.2 Reactome: R-HSA-5689603 UCH proteinases 54 EEZ97220.1;EFA07576.2;EFA01675.1;EFA02110.1;EEZ99725.1;KYB29360.1;KYB27557.1;EFA04065.1;EFA02345.1;EFA13218.1;EFA08911.2;EEZ99493.1;EEZ97876.1;KYB27556.1;EFA02260.2;EFA03341.1;KYB26764.1;EFA06519.1;EFA11079.1;EFA06741.1;EFA06200.1;KYB28049.1;KYB28293.1;EFA08664.1;EFA07261.2;EEZ97564.1;EFA05865.1;EFA04054.1;EFA08798.1;EFA09524.2;EFA08601.1;EFA09518.2;EFA07659.2;EFA05871.2;EFA02331.1;EEZ98185.1;EFA00828.1;EFA05105.1;EFA01003.1;EFA03019.1;KYB26545.1;EEZ97734.1;KYB29359.1;EFA05912.1;EFA00904.1;EFA07110.1;EFA06996.2;KYB24713.1;EFA05833.1;EEZ99004.1;EFA06841.1;EFA04284.1;KYB25309.1;EFA05370.2 KEGG: 00591+3.1.1.4 Linoleic acid metabolism 23 KYB29358.1;EFA12460.1;KYB26689.1;KYB27221.1;EFA11812.1;KYB27219.1;EFA13680.1;EEZ98801.1;EFA12309.1;EFA09487.1;EFA07860.2;EFA12575.1;KXZ75683.1;EEZ99784.2;KYB27220.1;EFA12193.1;EFA03430.2;EFA05083.2;EFA12278.1;EFA09107.1;EFA08691.1;EFA07968.1;EFA13468.1 KEGG: 00660+6.2.1.5 C5-Branched dibasic acid metabolism 5 EFA03750.1;EFA07160.1;EFA05014.1;EFA11129.1;EFA11202.1 Reactome: R-HSA-5602498 MyD88 deficiency (TLR2/4) 1 EFA01304.1 Reactome: R-HSA-73614 Pyrimidine salvage 6 EFA08865.1;EEZ97798.2;EFA11381.2;EEZ98936.1;EEZ98937.1;KYB28983.1 MetaCyc: PWY-7291 Oleate beta-oxidation (isomerase-dependent, yeast) 3 EFA09569.1;EFA11530.1;EFA09425.1 Reactome: R-HSA-1237044 Erythrocytes take up carbon dioxide and release oxygen 3 EFA07854.2;EEZ98339.1;EFA05074.1 MetaCyc: PWY-6733 Sporopollenin precursors biosynthesis 25 EEZ97388.1;KYB26690.1;EFA05235.1;EFA04973.1;EFA06889.2;EFA05090.1;EFA05103.1;KYB26274.1;EFA05404.1;EFA08474.2;EEZ97452.1;EFA08449.1;EFA05024.1;EFA05564.2;EFA07221.2;EEZ99525.1;EFA05205.1;EFA08470.2;EFA06888.2;EFA04917.2;EFA05234.1;KYB26083.1;KYB27109.1;EFA04974.1;EFA05233.2 Reactome: R-HSA-1566948 Elastic fibre formation 1 EFA10680.1 KEGG: 00531+3.1.6.14 Glycosaminoglycan degradation 1 EFA04898.1 Reactome: R-HSA-5654700 FRS-mediated FGFR2 signaling 1 EFA09507.1 KEGG: 00640+4.2.1.17 Propanoate metabolism 3 EFA04382.1;EFA08151.1;EFA05073.1 Reactome: R-HSA-8849471 PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases 1 EEZ97639.1 MetaCyc: PWY-5028 L-histidine degradation II 1 KYB26333.1 Reactome: R-HSA-73762 RNA Polymerase I Transcription Initiation 20 EFA08638.2;EEZ99110.1;EFA07302.1;EFA02310.1;EFA07055.2;KYB26622.1;EFA07031.1;EFA04470.1;EFA07284.1;KYB28470.1;EFA00018.1;KYB26273.1;EFA06006.1;EFA06469.1;EFA06839.2;EFA05896.1;EFA00328.1;EFA03150.1;KYB26001.1;KYB25378.1 Reactome: R-HSA-205043 NRIF signals cell death from the nucleus 8 KYB27078.1;EFA05049.2;EFA02110.1;KYB29359.1;EFA04103.1;KYB29360.1;EFA02851.1;EFA07178.2 Reactome: R-HSA-418597 G alpha (z) signalling events 17 KYB25864.1;EFA03629.2;EFA03625.2;KYB25556.1;KYB27619.1;KYB25555.1;KYB25552.1;KYB25554.1;KYB28863.1;EFA07406.1;EFA03628.1;EFA03954.2;KYB27523.1;EFA07407.1;KYB25553.1;EFA01439.2;EFA10712.2 KEGG: 00052+2.7.7.12 Galactose metabolism 1 KYB28384.1 KEGG: 00592+4.2.1.17 alpha-Linolenic acid metabolism 3 EFA04382.1;EFA05073.1;EFA08151.1 Reactome: R-HSA-5083628 Defective POMGNT1 causes MDDGA3, MDDGB3 and MDDGC3 1 EFA06291.1 KEGG: 00920+2.7.7.4 Sulfur metabolism 1 EFA13134.1 Reactome: R-HSA-5358749 S37 mutants of beta-catenin aren't phosphorylated 4 EFA05992.2;KYB26383.1;KYB26642.1;EFA13272.2 KEGG: 00270+2.6.1.1 Cysteine and methionine metabolism 3 EFA04122.1;KYB27212.1;EFA03109.1 KEGG: 00930+4.2.1.17 Caprolactam degradation 1 EFA04382.1 Reactome: R-HSA-500753 Pyrimidine biosynthesis 4 EFA10197.1;EFA01834.2;EEZ97344.2;EFA01139.2 Reactome: R-HSA-111463 SMAC (DIABLO) binds to IAPs 5 EFA01361.1;KYB27349.1;EEZ98372.1;KYB27348.1;EFA08214.1 MetaCyc: PWY-6147 6-hydroxymethyl-dihydropterin diphosphate biosynthesis I 1 EFA13034.1 Reactome: R-HSA-174178 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 52 EFA07110.1;KYB27187.1;KYB29359.1;EFA05912.1;EFA01569.1;KYB25814.1;KYB26545.1;EFA05370.2;EFA04284.1;KYB25309.1;KYB24713.1;EEZ99004.1;EFA05833.1;EFA08798.1;EFA01854.1;EFA09524.2;EFA05865.1;EEZ99272.2;KYB27271.1;EFA04054.1;EFA07261.2;EEZ97564.1;EFA05105.1;EFA03019.1;EEZ98185.1;EFA02331.1;EFA09518.2;EFA05871.2;EFA07659.2;EFA08601.1;EFA00073.1;EFA03341.1;KYB26764.1;EEZ97189.1;KYB27556.1;EEZ97876.1;EFA08664.1;EFA06200.1;EFA06741.1;EEZ98737.1;EFA06519.1;EFA11079.1;EFA04231.1;EFA02110.1;EEZ97989.1;EEZ99493.1;EFA02345.1;EFA13218.1;EFA08911.2;EEZ98849.2;KYB27557.1;KYB29360.1 Reactome: R-HSA-376176 Signaling by ROBO receptors 3 EEZ99735.2;KYB28333.1;KYB27628.1 Reactome: R-HSA-5693554 Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) 18 EFA04612.2;EFA07487.1;EFA13005.2;EFA11787.2;KYB28817.1;EFA09584.2;EFA08701.2;EFA10219.1;EEZ97797.2;KYB26388.1;EFA08981.1;EEZ99558.2;KYB27777.1;EFA02866.1;EFA04568.2;EFA00407.2;EFA05681.1;EFA02865.1 KEGG: 00970+6.1.1.2 Aminoacyl-tRNA biosynthesis 2 EFA07367.1;EFA03333.2 KEGG: 00900+2.7.1.36 Terpenoid backbone biosynthesis 1 EFA05256.2 Reactome: R-HSA-6791055 TALDO1 deficiency: failed conversion of SH7P, GA3P to Fru(6)P, E4P 1 EEZ98187.1 KEGG: 00900+4.1.1.33 Terpenoid backbone biosynthesis 1 EFA00378.2 KEGG: 00480+1.1.1.44 Glutathione metabolism 1 EFA03025.1 MetaCyc: PWY-5189 Tetrapyrrole biosynthesis II (from glycine) 4 EFA03098.1;EFA03355.2;EFA07026.1;EFA10147.1 Reactome: R-HSA-8963693 Aspartate and asparagine metabolism 3 EFA06167.2;KYB27475.1;EFA06327.1 MetaCyc: PWY-7383 Anaerobic energy metabolism (invertebrates, cytosol) 15 EFA03109.1;EFA08842.1;EFA09643.1;KYB27212.1;KYB25941.1;EFA02482.1;EEZ97193.2;KYB24935.1;EFA04972.1;EEZ99016.2;KYB24934.1;EFA04122.1;KYB26254.1;EFA06223.2;EFA08832.2 Reactome: R-HSA-9033807 ABO blood group biosynthesis 1 EEZ98997.2 Reactome: R-HSA-168638 NOD1/2 Signaling Pathway 5 KYB29359.1;EFA02110.1;EFA02851.1;KYB29360.1;EFA11598.1 KEGG: 00983+3.5.4.5 Drug metabolism - other enzymes 1 EFA08865.1 Reactome: R-HSA-73817 Purine ribonucleoside monophosphate biosynthesis 11 KYB26701.1;EFA02192.2;EFA09313.1;EEZ98112.1;EFA11857.1;EEZ97659.2;EEZ97680.1;EFA11870.2;EFA08776.1;EEZ98830.1;KYB25818.1 KEGG: 00970+6.1.1.5 Aminoacyl-tRNA biosynthesis 2 EFA12136.2;EFA11240.1 MetaCyc: PWY-6958 Icosapentaenoate biosynthesis I (lower eukaryotes) 2 EFA05143.1;EFA03551.1 Reactome: R-HSA-418890 Role of second messengers in netrin-1 signaling 7 EFA02795.1;KYB25489.1;KYB28196.1;EFA04635.2;KYB27779.1;KYB28200.1;EFA02859.1 Reactome: R-HSA-8856825 Cargo recognition for clathrin-mediated endocytosis 28 KYB29360.1;KYB29729.1;EFA09517.2;EFA04065.1;EFA11193.1;EFA05670.1;EFA11425.1;EFA04947.1;EFA02108.2;EFA08119.1;EFA02110.1;EFA09688.1;KYB26997.1;KYB29704.1;EFA11263.1;EFA09781.1;EFA02270.2;KYB29705.1;EFA11218.2;EFA11080.2;KYB29706.1;EFA09116.1;EEZ99924.2;KYB25639.1;EFA02872.2;KYB29359.1;EFA11302.1;EFA12663.1 Reactome: R-HSA-3899300 SUMOylation of transcription cofactors 3 EFA02517.2;EFA04901.1;EFA06716.1 MetaCyc: PWY-6724 Starch degradation II 2 KYB25482.1;EFA10130.2 Reactome: R-HSA-877312 Regulation of IFNG signaling 3 KYB28833.1;EFA12064.1;EFA00470.2 Reactome: R-HSA-164939 Nef mediated downregulation of CD28 cell surface expression 1 EFA09781.1 Reactome: R-HSA-1237112 Methionine salvage pathway 6 EFA12349.2;EFA07386.2;EEZ99138.2;EEZ99144.1;EFA07698.1;EFA07663.1 KEGG: 00720+6.2.1.5 Carbon fixation pathways in prokaryotes 5 EFA03750.1;EFA05014.1;EFA07160.1;EFA11129.1;EFA11202.1 Reactome: R-HSA-937072 TRAF6-mediated induction of TAK1 complex within TLR4 complex 4 EFA02110.1;KYB29359.1;EFA02851.1;KYB29360.1 Reactome: R-HSA-381070 IRE1alpha activates chaperones 1 EEZ98819.2 Reactome: R-HSA-9652282 Drug-mediated inhibition of ERBB2 signaling 1 EFA03198.1 KEGG: 00520+2.7.1.1 Amino sugar and nucleotide sugar metabolism 4 KYB29371.1;KYB29370.1;EEZ97932.2;EEZ97931.1 KEGG: 00562+2.7.1.134+2.7.1.159 Inositol phosphate metabolism 1 EFA02124.1 MetaCyc: PWY-6289 Petrobactin biosynthesis 1 EEZ97421.2 MetaCyc: PWY-6728 Methylaspartate cycle 16 EFA04299.1;EFA10595.2;EFA09226.1;EFA11202.1;EFA02482.1;EFA03144.1;EFA03750.1;EFA05014.1;EFA09539.1;EFA03463.2;EFA02829.1;EFA04972.1;EFA11129.1;EFA04683.1;EFA10709.2;EFA07160.1 Reactome: R-HSA-167161 HIV Transcription Initiation 30 KYB28470.1;EFA00018.1;EEZ99738.1;EFA06469.1;EEZ97886.2;EFA07031.1;EFA03759.1;EFA05897.1;EEZ97398.2;KYB29038.1;EFA07302.1;EFA07055.2;EFA02310.1;KYB29037.1;KYB25378.1;EFA05523.2;EFA02321.1;EFA05226.1;KYB25152.1;EFA03150.1;EFA03550.1;EFA11878.1;KYB26001.1;EFA06560.1;EFA00328.1;EFA03052.1;EFA06253.1;EFA00911.1;EFA05896.1;EFA03093.1 KEGG: 00650+2.3.3.10 Butanoate metabolism 1 EFA06304.1 Reactome: R-HSA-77310 Beta oxidation of lauroyl-CoA to decanoyl-CoA-CoA 1 EFA04382.1 Reactome: R-HSA-1810476 RIP-mediated NFkB activation via ZBP1 1 EFA01304.1 KEGG: 00270+2.6.1.52 Cysteine and methionine metabolism 1 EEZ98123.1 KEGG: 00020+1.3.5.1 Citrate cycle (TCA cycle) 4 EFA09226.1;EFA04683.1;EFA10709.2;EFA02829.1 Reactome: R-HSA-196108 Pregnenolone biosynthesis 4 EEZ98188.2;EEZ97678.1;EFA07554.1;EFA04921.1 MetaCyc: PWY-7779 Methyl tert-butyl ether degradation 3 EFA04382.1;EFA08151.1;EFA05073.1 MetaCyc: PWY-5133 Colupulone and cohumulone biosynthesis 2 EFA12019.1;EFA12933.2 KEGG: 00130+2.1.1.222+2.1.1.64 Ubiquinone and other terpenoid-quinone biosynthesis 1 KYB26214.1 MetaCyc: PWY-7384 Anaerobic energy metabolism (invertebrates, mitochondrial) 7 EFA03750.1;EFA03144.1;EFA05014.1;EFA07160.1;EFA03463.2;EFA11129.1;EFA11202.1 KEGG: 00250+6.3.4.4 Alanine, aspartate and glutamate metabolism 1 KYB26701.1 Reactome: R-HSA-199220 Vitamin B5 (pantothenate) metabolism 9 EFA05204.2;EFA05203.2;EEZ97421.2;EFA02059.2;EFA05248.1;EFA11365.1;EFA05201.1;EFA05249.2;EEZ97866.2 KEGG: 00710+5.1.3.1 Carbon fixation in photosynthetic organisms 1 EEZ97576.1 KEGG: 00473+5.1.1.1 D-Alanine metabolism 1 EFA09643.1 KEGG: 00983+2.7.4.14 Drug metabolism - other enzymes 2 EFA11131.1;EFA06562.1 Reactome: R-HSA-5576886 Phase 4 - resting membrane potential 14 KYB27916.1;EFA02339.1;KYB26059.1;EFA07264.1;KYB27940.1;KYB24942.1;EFA08415.2;EFA09559.1;EEZ97944.1;EFA04915.1;EFA04896.1;KYB28656.1;EFA00608.2;KYB25451.1 KEGG: 00510+3.2.1.113 N-Glycan biosynthesis 1 EFA08227.2 MetaCyc: PWY-3961 Phosphopantothenate biosynthesis II 2 KYB29463.1;KYB29462.1 Reactome: R-HSA-6804758 Regulation of TP53 Activity through Acetylation 5 EFA06839.2;EFA08447.2;EFA04527.1;KYB26273.1;EFA02105.1 KEGG: 00600+3.2.1.23 Sphingolipid metabolism 9 EFA07841.1;EEZ99315.1;EEZ99316.1;KYB26528.1;EFA07842.1;EFA04110.1;EFA06933.2;EFA07843.2;EEZ97806.1 Reactome: R-HSA-211976 Endogenous sterols 3 EEZ98188.2;EEZ97678.1;EFA04921.1 MetaCyc: PWY-7222 Guanosine deoxyribonucleotides de novo biosynthesis II 8 EFA02202.1;EFA02203.1;EEZ98594.1;KYB26165.1;EFA07171.1;EFA03917.1;EFA03825.1;EEZ99726.1 MetaCyc: PWY-5941 Glycogen degradation II 3 EFA02541.1;EFA10130.2;KYB25482.1 KEGG: 00590+5.3.99.3 Arachidonic acid metabolism 1 EFA00341.1 MetaCyc: PWY-7288 Fatty acid beta-oxidation VII (yeast peroxisome) 3 EFA09569.1;EFA09425.1;EFA11530.1 Reactome: R-HSA-947581 Molybdenum cofactor biosynthesis 6 EFA02449.2;EFA04185.1;EEZ98181.1;EFA06321.2;EEZ98196.1;EEZ98663.1 KEGG: 00230+1.1.1.205 Purine metabolism 1 EFA11857.1 KEGG: 00627+4.2.1.17 Aminobenzoate degradation 3 EFA05073.1;EFA08151.1;EFA04382.1 KEGG: 00980+1.1.1.1 Metabolism of xenobiotics by cytochrome P450 1 EEZ98950.2 KEGG: 00190+1.3.5.1 Oxidative phosphorylation 4 EFA02829.1;EFA10709.2;EFA04683.1;EFA09226.1 MetaCyc: PWY-7821 Tunicamycin biosynthesis 3 EFA04414.1;EFA03919.1;EFA01792.1 Reactome: R-HSA-5625886 Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 1 KYB24563.1 MetaCyc: PWY-3881 Mannitol biosynthesis 1 EFA01794.1 Reactome: R-HSA-212300 PRC2 methylates histones and DNA 4 KYB29654.1;EFA00645.1;KYB24563.1;EEZ97202.2 MetaCyc: PWY-7226 Guanosine deoxyribonucleotides de novo biosynthesis I 8 EEZ99726.1;EFA03825.1;EFA03917.1;KYB26165.1;EFA07171.1;EEZ98594.1;EFA02203.1;EFA02202.1 KEGG: 00513+3.2.1.113 Various types of N-glycan biosynthesis 1 EFA08227.2 Reactome: R-HSA-6798695 Neutrophil degranulation 111 EEZ97708.2;EFA04455.2;EFA07971.1;EEZ97227.1;EFA04965.1;EFA10857.2;EFA09317.1;EFA05014.1;EFA07026.1;EFA06092.2;KYB25350.1;EFA00408.1;EFA08601.1;EEZ99723.1;EFA08516.2;KYB26527.1;KYB27808.1;EEZ97420.1;EFA05480.2;EFA07841.1;EFA02668.2;KYB25457.1;KYB28295.1;EFA04221.1;EFA09153.1;EFA07651.2;KYB28628.1;EFA09462.2;EFA08249.1;EFA07843.2;EFA02242.2;EFA12722.1;EFA12467.1;EFA03479.1;EFA11602.1;EFA01732.2;EFA01288.1;EFA02897.1;EFA03341.1;EFA12724.1;KYB27556.1;EEZ98372.1;EFA01564.1;EFA07465.1;EFA04898.1;EFA08605.1;EEZ98394.2;EFA12496.1;KYB26528.1;EFA11079.1;EFA11745.1;EFA09154.2;EFA05744.1;EFA04054.1;EFA01287.1;EFA02388.1;KYB25482.1;EFA01001.1;EFA07177.2;EFA03659.1;EFA07537.1;EFA08278.1;EFA09821.2;EFA05871.2;EFA10984.1;EEZ97738.1;EFA03250.2;EFA07795.2;EFA02044.2;EFA04962.1;EEZ97852.2;EFA04011.1;EEZ98562.1;EFA07842.1;EFA00339.1;KYB26545.1;EFA00210.2;EFA00684.1;KYB28573.1;EFA02898.2;KYB25309.1;EFA00341.1;EFA09803.1;EFA09480.2;EFA06933.2;KYB25428.1;EFA07687.2;EFA11857.1;KYB28799.1;EFA00166.1;KYB28627.1;EEZ97799.1;KYB28918.1;EFA10130.2;KYB27557.1;EEZ99233.1;EEZ98209.1;EFA05049.2;EFA00425.1;EFA01289.1;EFA01286.1;EFA02241.1;EFA00313.1;EFA08664.1;EEZ97210.1;EEZ99549.1;EFA11080.2;EFA08865.1;EEZ97857.1;KYB29852.1;EFA06669.1 Reactome: R-HSA-209968 Thyroxine biosynthesis 3 EFA01258.2;EFA11561.2;KYB28422.1 Reactome: R-HSA-9648025 EML4 and NUDC in mitotic spindle formation 43 KYB27370.1;EEZ97487.2;EFA04506.2;KYB25235.1;EFA09410.1;EFA07823.1;EEZ97891.1;EFA07920.2;EFA04692.2;KYB25744.1;EFA06663.1;KYB29624.1;KYB26642.1;EEZ97229.1;KYB25236.1;EFA00171.1;EFA09537.1;KYB27439.1;KYB25237.1;EFA11292.1;EFA09995.1;EFA04833.1;KYB26892.1;EFA05992.2;EFA07755.2;KYB25071.1;KYB26625.1;KYB25072.1;EFA06187.1;EEZ99331.1;EFA06856.2;EFA07500.2;EFA13202.2;KYB26929.1;EEZ99348.1;KYB25616.1;EEZ99070.2;EFA11447.2;EEZ97419.2;EFA06492.1;EFA09822.2;EFA07677.2;KYB26383.1 MetaCyc: PWY-5538 Pyruvate fermentation to acetate VI 5 EFA07160.1;EFA05014.1;EFA03750.1;EFA11202.1;EFA11129.1 KEGG: 00270+1.1.1.37 Cysteine and methionine metabolism 2 EFA02482.1;EFA04972.1 Reactome: R-HSA-447038 NrCAM interactions 1 KYB29108.1 KEGG: 00561+2.3.1.51 Glycerolipid metabolism 6 EEZ97656.1;KYB27110.1;EFA02132.1;KYB27111.1;EEZ97257.1;EFA04525.1 Reactome: R-HSA-5684264 MAP3K8 (TPL2)-dependent MAPK1/3 activation 5 EFA02847.1;KYB29359.1;EFA02110.1;EEZ99274.1;KYB29360.1 KEGG: 00970+6.1.1.15 Aminoacyl-tRNA biosynthesis 2 EEZ98764.2;KYB26719.1 MetaCyc: PWY-5884 Wax esters biosynthesis I 25 EFA05234.1;EFA05233.2;KYB27109.1;KYB26083.1;EFA04974.1;EFA06888.2;EFA08470.2;EFA04917.2;EFA05205.1;EEZ99525.1;EFA05024.1;EFA08449.1;EEZ97452.1;EFA07221.2;EFA05564.2;EFA08474.2;EFA05090.1;EFA06889.2;EFA05404.1;KYB26274.1;EFA05103.1;EFA05235.1;EFA04973.1;EEZ97388.1;KYB26690.1 Reactome: R-HSA-611105 Respiratory electron transport 68 EFA02862.1;EFA00450.1;KYB28574.1;EFA04686.2;EEZ97756.1;EFA10149.1;EFA09221.1;EFA07507.1;EFA07586.1;EFA07587.1;EFA04705.1;EFA05568.1;EFA10816.2;EFA09869.1;EFA09231.1;EFA07588.1;KYB25738.1;EFA07503.1;EFA09226.1;KYB26900.1;EFA10794.1;EFA04600.1;EEZ99263.1;EFA01357.1;EFA01361.1;EFA05757.1;EFA07471.1;EFA10667.1;EFA07535.1;EFA11105.1;EFA04664.1;EFA05672.1;EFA07408.1;EFA05396.1;EEZ97742.1;EFA02878.1;KYB25739.1;EEZ99191.1;EFA07505.2;EFA09217.1;EEZ97472.1;EFA12825.1;EEZ97690.1;EFA11572.1;EEZ98766.1;EFA01282.1;EEZ99280.1;EFA04683.1;EFA10709.2;EEZ99264.1;EFA08214.1;EFA10746.1;EFA12181.1;EFA01736.1;EFA02829.1;EFA10819.1;EFA07439.1;EFA04681.1;EEZ97697.1;EFA00352.1;EFA07540.1;EFA01338.1;EFA10817.2;EFA05895.1;KYB27348.1;KYB27349.1;EFA10821.1;EFA05697.1 Reactome: R-HSA-912526 Interleukin receptor SHC signaling 1 KYB29656.1 Reactome: R-HSA-933542 TRAF6 mediated NF-kB activation 1 EFA02851.1 Reactome: R-HSA-139915 Activation of PUMA and translocation to mitochondria 2 EFA12881.2;EFA12882.1 Reactome: R-HSA-1834949 Cytosolic sensors of pathogen-associated DNA 18 EEZ99162.2;EFA01191.1;EFA02494.1;EFA07655.1;EFA03479.1;EFA07031.1;EFA07537.1;EFA07284.1;KYB28470.1;KYB26491.1;EFA11622.1;EFA07487.1;EFA05896.1;EFA09807.1;EFA07935.1;EEZ99545.1;EFA03150.1;KYB26001.1 MetaCyc: PWY-6113 Superpathway of mycolate biosynthesis 7 EFA05248.1;EFA11365.1;EEZ97866.2;EFA05204.2;EFA05201.1;EFA05249.2;EFA05203.2 Reactome: R-HSA-1474244 Extracellular matrix organization 2 KYB27188.1;EFA04092.2 Reactome: R-HSA-5694530 Cargo concentration in the ER 8 EFA04607.2;EFA06622.1;EFA01820.1;KYB26644.1;KYB27195.1;EFA10355.1;KYB24587.1;EFA06320.2 Reactome: R-HSA-2395516 Electron transport from NADPH to Ferredoxin 3 EFA04921.1;EEZ98188.2;EEZ97678.1 Reactome: R-HSA-1483115 Hydrolysis of LPC 2 KYB27179.1;EFA03495.2 Reactome: R-HSA-1169408 ISG15 antiviral mechanism 26 KYB29271.1;EFA07823.1;KYB29364.1;EFA01782.2;EFA01249.2;KYB29359.1;KYB28401.1;EFA03859.1;KYB28630.1;EEZ98695.2;EFA04928.2;EFA11141.2;EFA09537.1;KYB29624.1;EEZ98092.1;EFA05993.1;EFA00605.1;EFA02110.1;EEZ98471.1;EFA03584.1;EFA04216.2;EFA00581.2;KYB29360.1;EEZ97868.2;EFA11447.2;EFA00919.1 Reactome: R-HSA-8951430 RUNX3 regulates WNT signaling 4 KYB28556.1;KYB28559.1;KYB28557.1;KYB28558.1 Reactome: R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance 30 EFA03759.1;EFA05897.1;EFA07031.1;KYB29038.1;EEZ97398.2;KYB28470.1;EFA00018.1;EEZ97886.2;EFA06469.1;EEZ99738.1;EFA07302.1;EFA02310.1;EFA07055.2;EFA03550.1;EFA03150.1;EFA11878.1;KYB26001.1;EFA06560.1;EFA02321.1;EFA05226.1;KYB25378.1;KYB29037.1;EFA05523.2;KYB25152.1;EFA00911.1;EFA05896.1;EFA03093.1;EFA06253.1;EFA00328.1;EFA03052.1 KEGG: 00240+2.4.2.3 Pyrimidine metabolism 2 EEZ98937.1;EEZ98936.1 KEGG: 00310+4.2.1.17+1.1.1.35 Lysine degradation 3 EFA08151.1;EFA05073.1;EFA04382.1 Reactome: R-HSA-111457 Release of apoptotic factors from the mitochondria 4 EFA01361.1;EFA08214.1;KYB27348.1;KYB27349.1 Reactome: R-HSA-426117 Cation-coupled Chloride cotransporters 5 EFA11214.2;KYB29730.1;EFA05305.2;KYB29205.1;EFA04772.2 Reactome: R-HSA-5358565 Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) 13 KYB25721.1;EFA07958.1;EFA13005.2;EFA09711.2;EFA10321.2;EFA06042.1;KYB28926.1;KYB27483.1;EFA08028.2;EFA11424.2;EFA09906.2;EFA12891.1;KYB28925.1 KEGG: 00730+3.1.3.2 Thiamine metabolism 1 KYB24625.1 Reactome: R-HSA-177504 Retrograde neurotrophin signalling 2 EFA11263.1;EFA09781.1 Reactome: R-HSA-2424491 DAP12 signaling 2 EFA12319.2;KXZ75916.1 Reactome: R-HSA-2173788 Downregulation of TGF-beta receptor signaling 15 EFA02685.2;EFA10728.2;EFA07576.2;KYB29359.1;EFA02110.1;EEZ97734.1;EFA05189.1;EFA08658.1;KYB27758.1;EFA05099.1;KYB28159.1;KYB27757.1;EEZ99725.1;KYB29360.1;EFA09995.1 Reactome: R-HSA-196819 Vitamin B1 (thiamin) metabolism 4 EEZ98443.2;EFA09905.2;KYB29167.1;EFA01517.1 MetaCyc: PWY-6700 Queuosine biosynthesis I (de novo) 2 EFA00359.1;EFA02997.1 Reactome: R-HSA-1912408 Pre-NOTCH Transcription and Translation 14 EFA08972.2;EFA04626.2;EEZ97204.1;KYB24943.1;EEZ99094.1;EFA09197.2;EFA04470.1;KYB24563.1;EEZ99435.2;KYB26000.1;KYB25999.1;EFA02517.2;KYB25778.1;EFA11590.1 Reactome: R-HSA-917937 Iron uptake and transport 6 EFA04065.1;EFA02847.1;KYB29359.1;EFA02110.1;EFA02996.1;KYB29360.1 MetaCyc: PWY-7996 Menaquinol-4 biosynthesis I 2 KYB27131.1;EFA05173.2 Reactome: R-HSA-8876198 RAB GEFs exchange GTP for GDP on RABs 40 EFA09533.1;KYB27812.1;EFA12998.1;KYB25415.1;EFA07324.1;KXZ75822.1;EFA07850.1;EFA09994.1;EFA02190.1;EFA02135.1;KYB27813.1;EFA02112.2;EFA02105.1;EFA06262.1;EFA12610.1;KYB25316.1;EFA03502.1;EFA03885.1;EEZ99123.1;EFA02178.2;EFA10428.2;EFA06481.2;KYB27811.1;KYB25414.1;EFA04485.1;EFA02072.1;EFA11313.1;EFA11536.1;EEZ98120.2;EFA06979.1;EFA01590.1;EFA06745.1;EFA01887.1;EFA00389.1;EFA12180.1;EFA10011.2;EFA10326.1;KYB25955.1;EEZ98522.2;KXZ75821.1 KEGG: 00670+2.1.1.45 One carbon pool by folate 2 EFA02095.1;EFA11748.1 Reactome: R-HSA-9637628 Modulation by Mtb of host immune system 3 EFA02110.1;KYB29359.1;KYB29360.1 Reactome: R-HSA-9665245 Resistance of ERBB2 KD mutants to tesevatinib 1 EFA03198.1 KEGG: 00130+4.1.1.90 Ubiquinone and other terpenoid-quinone biosynthesis 1 EFA03079.2 KEGG: 00730+2.2.1.7 Thiamine metabolism 1 EFA11181.1 Reactome: R-HSA-9609690 HCMV Early Events 38 EFA01249.2;EEZ97487.2;KYB28401.1;KYB29271.1;EFA07823.1;EFA04928.2;EEZ97891.1;EFA00645.1;KYB28630.1;EFA00605.1;EFA06663.1;EFA09537.1;EFA11141.2;EEZ97229.1;KYB29624.1;EFA11292.1;KYB24563.1;EEZ97868.2;KYB26892.1;EFA03584.1;EFA04833.1;EFA00581.2;EFA01782.2;KYB25071.1;KYB26625.1;EFA03859.1;EEZ99331.1;KYB25072.1;KYB29364.1;EFA06187.1;EFA07303.1;EEZ98695.2;EFA05993.1;EEZ99348.1;KYB26929.1;EEZ99070.2;EFA11447.2;EFA09822.2 KEGG: 00908+2.5.1.75 Zeatin biosynthesis 1 EEZ99485.2 KEGG: 00410+2.6.1.19 beta-Alanine metabolism 2 KYB25521.1;KYB25522.1 KEGG: 00564+3.1.4.4 Glycerophospholipid metabolism 2 EFA02113.2;KYB27775.1 Reactome: R-HSA-5675482 Regulation of necroptotic cell death 3 EFA02110.1;KYB29359.1;KYB29360.1 Reactome: R-HSA-72649 Translation initiation complex formation 48 EFA03441.1;EFA02515.1;EFA00505.1;EEZ98503.1;EFA08849.1;EFA11360.1;EFA00209.1;KYB25876.1;EFA10123.1;KYB29360.1;EFA01765.1;EFA05867.1;KYB27801.1;EFA11293.1;KYB26424.1;EFA04159.1;EFA06707.1;EFA09970.1;EEZ99023.1;EFA00935.2;EFA10201.2;EFA06382.1;EFA05373.1;EEZ97313.1;EEZ98728.1;EFA09067.1;EFA08366.2;EEZ99942.1;EEZ97645.1;EFA01611.1;EFA10249.1;EFA02554.1;EFA04093.1;EFA09390.1;EFA06341.1;EEZ99635.1;EFA08069.1;EFA07317.1;EEZ98852.1;KYB29359.1;EFA04453.1;EFA13692.2;EFA05170.2;EFA07164.1;EFA06534.1;EEZ97224.1;EEZ99099.1;EFA07141.1 MetaCyc: PWY-7586 Beta-1,4-d-mannosyl-n-acetyl-d-glucosamine degradation 2 EFA07975.2;EFA01794.1 MetaCyc: PWY-6342 Noradrenaline and adrenaline degradation 1 EEZ98950.2 Reactome: R-HSA-173599 Formation of the active cofactor, UDP-glucuronate 3 KYB28935.1;KYB28936.1;EFA06874.2 Reactome: R-HSA-350562 Regulation of ornithine decarboxylase (ODC) 39 KYB26764.1;EFA03341.1;EEZ97876.1;KYB27556.1;EFA08664.1;EFA06200.1;EFA06741.1;EFA11079.1;KYB26640.1;EFA06519.1;EEZ99493.1;EFA08911.2;EFA13218.1;EFA02345.1;KYB27557.1;EFA07110.1;EFA05912.1;KYB26545.1;EFA05370.2;EFA04284.1;KYB25309.1;EFA05833.1;EEZ99004.1;KYB24713.1;EFA09524.2;EFA08798.1;EFA04054.1;EFA05865.1;EEZ97564.1;EFA07261.2;EFA03019.1;EFA05105.1;EFA02331.1;EEZ98185.1;EFA06676.2;EFA07659.2;EFA05871.2;EFA09518.2;EFA08601.1 MetaCyc: PWY-5381 Pyridine nucleotide cycling (plants) 5 EFA01792.1;EEZ97420.1;EFA10857.2;EFA01802.1;EFA10127.2 MetaCyc: PWY-5188 Tetrapyrrole biosynthesis I (from glutamate) 6 EFA03098.1;KYB26720.1;EFA07026.1;EFA03776.2;KYB27531.1;EFA10147.1 MetaCyc: PWY-4661 1D-myo-inositol hexakisphosphate biosynthesis III (Spirodela polyrrhiza) 4 KYB25213.1;EFA02124.1;EFA10622.1;EFA09280.1 KEGG: 00564+3.1.3.4 Glycerophospholipid metabolism 2 KYB26367.1;EFA07054.2 MetaCyc: PWY-5651 L-tryptophan degradation to 2-amino-3-carboxymuconate semialdehyde 2 EEZ98408.1;KYB25672.1 KEGG: 04070+2.7.1.107 Phosphatidylinositol signaling system 11 EFA08801.2;EFA03802.2;KYB29048.1;KYB29060.1;KYB25925.1;KYB26618.1;KYB26617.1;KYB29047.1;KYB29061.1;EEZ98328.2;KYB29049.1 Reactome: R-HSA-9029558 NR1H2 & NR1H3 regulate gene expression linked to lipogenesis 8 EFA05204.2;EFA05203.2;EFA05248.1;EFA02059.2;EFA11365.1;EFA05249.2;EFA05201.1;EEZ97866.2 Reactome: R-HSA-977347 Serine biosynthesis 3 EEZ98123.1;EFA01638.1;EFA03337.1 Reactome: R-HSA-1369007 Mitochondrial ABC transporters 1 EFA05094.1 Reactome: R-HSA-174184 Cdc20:Phospho-APC/C mediated degradation of Cyclin A 52 KYB29360.1;EEZ98849.2;KYB27557.1;EFA13218.1;EFA02345.1;EFA08911.2;EEZ99493.1;EEZ97989.1;EFA02110.1;EFA04231.1;EFA06519.1;EFA11079.1;EFA06741.1;EEZ98737.1;EFA06200.1;EFA08664.1;KYB27556.1;EEZ97876.1;EEZ97189.1;EFA03341.1;EFA00073.1;KYB26764.1;EFA08601.1;EFA09518.2;EFA07659.2;EFA05871.2;EFA02331.1;EEZ98185.1;EFA05105.1;EFA03019.1;EFA07261.2;EEZ97564.1;EEZ99272.2;EFA05865.1;EFA04054.1;KYB27271.1;EFA08798.1;EFA09524.2;EFA01854.1;KYB24713.1;EEZ99004.1;EFA05833.1;KYB25309.1;EFA04284.1;EFA05370.2;KYB25814.1;KYB26545.1;EFA01569.1;KYB29359.1;EFA05912.1;EFA07110.1;KYB27187.1 MetaCyc: PWY-7216 (R)- and (S)-3-hydroxybutanoate biosynthesis (engineered) 3 EFA04382.1;EFA08151.1;EFA05073.1 Reactome: R-HSA-5603037 IRAK4 deficiency (TLR5) 1 EFA01304.1 KEGG: 00020+2.3.3.8 Citrate cycle (TCA cycle) 1 EFA05014.1 Reactome: R-HSA-804914 Transport of fatty acids 1 EFA05391.1 Reactome: R-HSA-977443 GABA receptor activation 7 EFA12941.2;EFA02903.1;KYB24597.1;EFA02804.1;KYB24596.1;KYB28119.1;EFA02907.2 KEGG: 00520+3.2.1.52 Amino sugar and nucleotide sugar metabolism 10 EEZ98597.1;EFA10268.1;EFA05960.2;EFA07069.1;EFA06863.2;EFA05959.1;EFA11380.2;KYB25657.1;EFA06836.2;EFA08995.1 KEGG: 00620+6.2.1.1 Pyruvate metabolism 2 EFA12019.1;EFA12933.2 KEGG: 00790+3.5.4.16 Folate biosynthesis 1 EFA13034.1 KEGG: 00630+3.5.1.9 Glyoxylate and dicarboxylate metabolism 1 KYB25672.1 Reactome: R-HSA-112409 RAF-independent MAPK1/3 activation 3 EFA10708.1;EFA11234.1;EFA10433.2 Reactome: R-HSA-381753 Olfactory Signaling Pathway 2 KYB29439.1;EFA06115.1 KEGG: 00561+2.7.7.9 Glycerolipid metabolism 1 EFA06874.2 KEGG: 00510+2.4.1.256 N-Glycan biosynthesis 1 EFA11523.2 Reactome: R-HSA-9617324 Negative regulation of NMDA receptor-mediated neuronal transmission 4 KYB28360.1;KYB29108.1;EEZ99807.2;EFA09715.1 KEGG: 00627+3.6.1.7 Aminobenzoate degradation 2 EFA09358.1;KYB26572.1 MetaCyc: PWY-5461 Betanidin degradation 1 EFA01243.1 KEGG: 00360+2.6.1.1 Phenylalanine metabolism 3 KYB27212.1;EFA04122.1;EFA03109.1 Reactome: R-HSA-171306 Packaging Of Telomere Ends 2 EEZ98702.1;KYB24563.1 Reactome: R-HSA-109704 PI3K Cascade 1 EEZ98191.1 MetaCyc: PWY-7918 Protein N-glycosylation processing phase (yeast) 1 KYB25099.1 Reactome: R-HSA-9656256 Defective OGG1 Substrate Processing 1 EFA06198.1 Reactome: R-HSA-8964315 G beta:gamma signalling through BTK 1 KYB25864.1 MetaCyc: PWY-8012 Mupirocin biosynthesis 7 EFA11365.1;EEZ97866.2;EFA05248.1;EFA05203.2;EFA05204.2;EFA05249.2;EFA05201.1 Reactome: R-HSA-5668599 RHO GTPases Activate NADPH Oxidases 3 EFA00919.1;EEZ98191.1;EFA10708.1 KEGG: 00930+4.2.1.17+1.1.1.35 Caprolactam degradation 3 EFA04382.1;EFA05073.1;EFA08151.1 Reactome: R-HSA-112043 PLC beta mediated events 6 EFA10835.1;EFA11212.2;EFA04253.1;KYB27786.1;KYB27925.1;KYB29732.1 Reactome: R-HSA-6803204 TP53 Regulates Transcription of Genes Involved in Cytochrome C Release 4 EFA12881.2;EFA12882.1;EFA11787.2;KXZ75834.1 Reactome: R-HSA-2564830 Cytosolic iron-sulfur cluster assembly 7 KYB25409.1;EFA00451.1;EFA08218.1;EEZ99063.1;EFA00018.1;EFA10307.1;KYB25099.1 KEGG: 00061+1.1.1.100+2.3.1.85+4.2.1.59+2.3.1.39+2.3.1.41+3.1.2.14 Fatty acid biosynthesis 7 EFA05248.1;EEZ97866.2;EFA11365.1;EFA05204.2;EFA05201.1;EFA05249.2;EFA05203.2 KEGG: 04070+2.7.8.11 Phosphatidylinositol signaling system 1 EFA05079.1 MetaCyc: PWY-6906 Chitin derivatives degradation 5 EFA09778.2;EFA02005.2;EFA08071.1;EFA00108.1;KYB27794.1 MetaCyc: PWY-7416 Phospholipid remodeling (phosphatidylcholine, yeast) 23 KYB26689.1;KYB27221.1;EFA12460.1;KYB29358.1;KYB27219.1;EFA11812.1;EEZ99784.2;EFA12575.1;KXZ75683.1;EFA07860.2;EFA09487.1;EFA12309.1;EEZ98801.1;EFA13680.1;EFA07968.1;EFA13468.1;EFA08691.1;EFA09107.1;EFA12278.1;EFA05083.2;EFA03430.2;EFA12193.1;KYB27220.1 KEGG: 00534+5.1.3.17 Glycosaminoglycan biosynthesis - heparan sulfate / heparin 1 EFA10381.1 Reactome: R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA 14 EFA08115.1;EEZ98143.1;EEZ98144.2;EFA05896.1;KYB25152.1;EFA05226.1;KYB28470.1;EFA06415.1;KYB26001.1;EEZ97398.2;EFA06560.1;EFA03550.1;EFA07031.1;EFA03150.1 Reactome: R-HSA-381042 PERK regulates gene expression 2 EFA07164.1;EEZ98819.2 Reactome: R-HSA-180534 Vpu mediated degradation of CD4 41 EEZ99493.1;EFA13218.1;EFA02345.1;EFA08911.2;KYB27557.1;KYB29360.1;EFA02110.1;EFA08664.1;EFA06200.1;EFA06741.1;EFA06519.1;EFA11079.1;EFA03341.1;KYB26764.1;EFA02847.1;KYB27556.1;EEZ97876.1;EFA05105.1;EFA03019.1;EEZ98185.1;EFA02331.1;EFA09518.2;EFA07659.2;EFA05871.2;EFA08601.1;EFA08798.1;EFA09524.2;EFA05865.1;EFA04054.1;EFA07261.2;EEZ97564.1;EFA05370.2;KYB25309.1;EFA04284.1;KYB24713.1;EFA05833.1;EEZ99004.1;EFA07110.1;KYB29359.1;EFA05912.1;KYB26545.1 KEGG: 00280+4.2.1.17+1.1.1.35 Valine, leucine and isoleucine degradation 3 EFA08151.1;EFA05073.1;EFA04382.1 Reactome: R-HSA-73621 Pyrimidine catabolism 8 EEZ98937.1;KYB25712.1;KYB29062.1;EFA03092.1;EEZ98936.1;EFA06359.1;EEZ98343.1;EFA01139.2 MetaCyc: PWY-7013 (S)-propane-1,2-diol degradation 1 EEZ98950.2 Reactome: R-HSA-4419969 Depolymerisation of the Nuclear Lamina 4 EFA01129.2;KYB26367.1;EFA07054.2;EFA05796.2 KEGG: 00680+1.1.1.284 Methane metabolism 1 EEZ98950.2 Reactome: R-HSA-73933 Resolution of Abasic Sites (AP sites) 3 EFA12889.2;KXZ75899.1;KYB26857.1 KEGG: 00350+1.13.11.5 Tyrosine metabolism 1 EFA07806.1 Reactome: R-HSA-8866907 Activation of the TFAP2 (AP-2) family of transcription factors 2 EFA07527.2;EFA02517.2 Reactome: R-HSA-8866423 VLDL assembly 8 EFA11302.1;EFA03647.1;EFA08014.1;EFA11425.1;KYB29705.1;KYB29706.1;KYB26997.1;KYB29704.1 Reactome: R-HSA-71384 Ethanol oxidation 5 EEZ98950.2;KYB29291.1;EFA08453.1;EFA12933.2;EFA08452.1 MetaCyc: PWY-2221 Entner-Doudoroff pathway III (semi-phosphorylative) 12 EFA03133.1;EFA08842.1;KYB24934.1;EFA10016.2;EFA08832.2;EFA09609.1;EFA10506.1;EEZ97193.2;EFA09610.1;KYB25941.1;EEZ99016.2;KYB24935.1 Reactome: R-HSA-3371599 Defective HLCS causes multiple carboxylase deficiency 5 EFA03463.2;KYB27787.1;EFA05264.2;EFA05436.2;EFA03540.1 MetaCyc: PWY-5265 Peptidoglycan biosynthesis II (staphylococci) 3 EEZ98644.1;KYB27827.1;EFA02198.2 Reactome: R-HSA-400206 Regulation of lipid metabolism by PPARalpha 7 EFA08558.1;KYB28595.1;EFA06431.1;EFA00806.2;KYB28596.1;KYB26838.1;EFA10996.1 KEGG: 00680+3.1.3.3 Methane metabolism 1 EFA01638.1 KEGG: 00340+4.3.1.3 Histidine metabolism 1 KYB26333.1 MetaCyc: PWY-6134 L-tyrosine biosynthesis IV 1 EEZ99507.1 KEGG: 00230+2.7.4.3 Purine metabolism 10 EFA03918.2;EFA05847.1;EFA03917.1;EFA11131.1;EFA11124.1;KYB29097.1;EFA06480.1;KYB27609.1;EFA06562.1;EFA03645.2 Reactome: R-HSA-9027277 Erythropoietin activates Phospholipase C gamma (PLCG) 2 KXZ75916.1;EFA12319.2 KEGG: 00010+1.1.1.1 Glycolysis / Gluconeogenesis 1 EEZ98950.2 MetaCyc: PWY-6142 Gluconeogenesis II (Methanobacterium thermoautotrophicum) 19 KYB25941.1;EFA09610.1;EFA04932.1;EEZ97193.2;KYB29101.1;EFA09609.1;EFA10506.1;EFA08832.2;EFA01748.1;EFA07687.2;EFA00432.1;KYB24935.1;EEZ99016.2;EEZ98484.1;KYB24934.1;KYB27787.1;EFA04508.1;EFA08842.1;EFA11790.2 Reactome: R-HSA-8951911 RUNX3 regulates RUNX1-mediated transcription 2 EFA03630.2;KYB27618.1 KEGG: 00982+2.5.1.18 Drug metabolism - cytochrome P450 4 EFA08560.1;EEZ99479.1;EEZ99480.1;EFA00963.1 Reactome: R-HSA-5693568 Resolution of D-loop Structures through Holliday Junction Intermediates 23 EFA09584.2;KYB29298.1;EFA08701.2;EFA10219.1;KYB26388.1;EEZ97797.2;EFA04612.2;KYB29297.1;EFA07487.1;EFA11787.2;EFA13005.2;EFA05251.1;KYB28817.1;EFA02866.1;EFA04568.2;KYB27777.1;EFA02865.1;EFA05681.1;EFA00407.2;EFA08397.1;EFA07432.1;EEZ99558.2;EFA08981.1 Reactome: R-HSA-4090294 SUMOylation of intracellular receptors 3 EFA01263.2;KYB28389.1;EFA06716.1 MetaCyc: PWY-7338 10-trans-heptadecenoyl-CoA degradation (reductase-dependent, yeast) 3 EFA11530.1;EFA09425.1;EFA09569.1 Reactome: R-HSA-1474228 Degradation of the extracellular matrix 11 EFA09264.2;KYB28414.1;EFA01443.2;EFA08352.2;EFA09011.1;KYB28517.1;KYB27767.1;KYB28411.1;EFA05049.2;KYB26110.1;EFA04829.1 KEGG: 00720+4.2.1.17 Carbon fixation pathways in prokaryotes 1 EFA04382.1 MetaCyc: PWY-6891 Thiazole biosynthesis II (aerobic bacteria) 1 EFA11181.1 Reactome: R-HSA-1855183 Synthesis of IP2, IP, and Ins in the cytosol 6 EFA05415.1;EFA12936.1;EFA11114.1;EFA09280.1;EFA09929.2;KYB25020.1 Reactome: R-HSA-69183 Processive synthesis on the lagging strand 10 EFA10435.1;KYB28926.1;EFA07996.1;KYB28925.1;KYB25721.1;EFA09576.1;EFA07958.1;EFA07750.2;EFA06042.1;EFA04623.2 KEGG: 00330+1.5.5.2 Arginine and proline metabolism 1 EFA08381.1 Reactome: R-HSA-71064 Lysine catabolism 3 EFA07230.2;EFA12161.1;EFA08703.1 MetaCyc: PWY-5108 L-isoleucine biosynthesis V 3 EEZ98004.1;EFA12019.1;EFA12933.2 MetaCyc: PWY-3801 Sucrose degradation II (sucrose synthase) 2 EFA06874.2;EFA07687.2 Reactome: R-HSA-5362798 Release of Hh-Np from the secreting cell 4 EEZ98535.2;KYB28973.1;EEZ98657.1;KYB29228.1 Reactome: R-HSA-5689877 Josephin domain DUBs 8 EFA01025.1;EFA07465.1;KYB29359.1;EFA02110.1;KYB26998.1;EFA10237.1;EFA03872.2;KYB29360.1 Reactome: R-HSA-3928665 EPH-ephrin mediated repulsion of cells 11 EFA05049.2;EFA11555.2;EFA04103.1;EFA07434.1;KYB27078.1;EFA04947.1;EFA02270.2;EFA11263.1;EFA09781.1;KYB26081.1;EFA07178.2 Reactome: R-HSA-110312 Translesion synthesis by REV1 16 EFA02110.1;KYB25740.1;KYB29360.1;EFA09906.2;EFA12891.1;EFA08916.1;EFA08812.2;EFA04888.1;KYB27483.1;EFA06042.1;EFA09711.2;KYB29359.1;EFA12420.2;EFA03020.2;EFA02756.1;EFA03814.1 KEGG: 00240+4.1.1.23 Pyrimidine metabolism 1 EFA01834.2 MetaCyc: PWY-5172 Acetyl-coa biosynthesis III (from citrate) 1 EFA05014.1 KEGG: 00650+1.3.5.1 Butanoate metabolism 4 EFA10709.2;EFA02829.1;EFA09226.1;EFA04683.1 MetaCyc: PWY-6613 Tetrahydrofolate salvage from 5,10-methenyltetrahydrofolate 3 EFA07236.1;EFA07809.2;KYB25818.1 MetaCyc: PWY-7822 Chitin degradation III (Serratia) 30 EFA06696.2;KYB26649.1;EFA06693.1;EFA10488.1;EFA06836.2;EFA00965.2;EFA06310.1;KYB26650.1;EFA06309.1;EFA06699.2;KYB26651.1;EFA06308.1;EFA05481.2;EFA06695.1;EFA05323.2;EFA06863.2;EFA07069.1;EFA10268.1;EEZ98597.1;EFA06923.1;EFA05960.2;KYB25657.1;EFA06694.1;EFA06698.1;EFA06311.1;EFA08995.1;EFA11380.2;EFA10939.1;EFA05959.1;EFA06307.1 Reactome: R-HSA-3270619 IRF3-mediated induction of type I IFN 5 EFA07537.1;EFA07487.1;EEZ99162.2;EFA08516.2;EFA03479.1 KEGG: 00514+2.4.1.109 Other types of O-glycan biosynthesis 7 EFA04002.2;EFA01829.1;EEZ97998.1;KYB27853.1;KYB27854.1;KYB26307.1;EFA03006.2 Reactome: R-HSA-156588 Glucuronidation 29 KYB27842.1;KYB25566.1;EEZ99783.2;EFA01500.1;EFA02977.2;EFA10104.1;KYB25037.1;KYB27844.1;EFA10103.2;KYB26547.1;KYB25475.1;EFA05873.2;KYB27843.1;KYB26371.1;KYB25245.1;EFA10106.1;KYB28033.1;EFA00947.2;EFA06497.2;EFA11928.2;KYB25474.1;KYB27855.1;KYB26675.1;EFA10102.2;EFA11927.1;EFA07157.1;KYB27856.1;KYB25473.1;EFA02010.1 MetaCyc: PWY-6537 4-aminobutanoate degradation II 2 KYB25521.1;KYB25522.1 KEGG: 00220+2.6.1.1 Arginine biosynthesis 3 EFA04122.1;KYB27212.1;EFA03109.1 KEGG: 00010+5.3.1.1 Glycolysis / Gluconeogenesis 1 EFA01748.1 Reactome: R-HSA-8876725 Protein methylation 6 EFA00625.1;EFA05895.1;EFA01765.1;EFA07465.1;KYB28824.1;KYB28399.1 MetaCyc: PWY-7218 Photosynthetic 3-hydroxybutanoate biosynthesis (engineered) 10 EFA08832.2;EFA10506.1;EFA09609.1;KYB24934.1;EEZ99016.2;KYB24935.1;EEZ97193.2;KYB25941.1;EFA09610.1;EFA08842.1 Reactome: R-HSA-2206302 MPS I - Hurler syndrome 1 KYB29004.1 Reactome: R-HSA-6804754 Regulation of TP53 Expression 1 EFA04698.2 KEGG: 00790+2.10.1.1 Folate biosynthesis 1 EFA02449.2 KEGG: 00720+1.3.5.1 Carbon fixation pathways in prokaryotes 4 EFA09226.1;EFA04683.1;EFA10709.2;EFA02829.1 KEGG: 00240+2.1.1.45 Pyrimidine metabolism 2 EFA11748.1;EFA02095.1 MetaCyc: PWY-5353 Arachidonate biosynthesis I (6-desaturase, lower eukaryotes) 2 EFA05143.1;EFA03551.1 KEGG: 00500+2.4.1.18 Starch and sucrose metabolism 8 EEZ98454.1;KYB29170.1;EFA11030.1;EEZ98450.1;EEZ98451.1;EEZ98206.2;KYB29169.1;EEZ98452.1 MetaCyc: PWY-7587 Oleate biosynthesis III (cyanobacteria) 8 EEZ97257.1;EFA09975.1;KYB27110.1;EFA02132.1;EEZ97656.1;EFA04525.1;KYB27111.1;EFA06119.2 Reactome: R-HSA-6783310 Fanconi Anemia Pathway 39 EFA07149.2;EFA12580.1;EEZ97459.2;EFA05817.1;KYB27483.1;EFA01677.2;EFA09906.2;EFA07432.1;EFA13288.2;EEZ98882.2;EEZ99114.1;EFA13516.1;KYB28048.1;KYB29359.1;EEZ97594.1;EFA07715.1;EFA13608.1;KYB25791.1;EFA02422.2;EFA12570.2;EFA12075.1;KYB27959.1;EFA05251.1;EFA04567.1;KYB29552.1;EEZ97282.2;KYB29360.1;EFA12891.1;KXZ75610.1;KXZ75611.1;EFA02110.1;KYB26189.1;KYB29551.1;EFA05477.1;KYB29298.1;KYB29297.1;EFA07621.2;EFA09711.2;EFA09410.1 MetaCyc: PWY-5136 Fatty acid beta-oxidation II (plant peroxisome) 6 EFA04382.1;EFA09569.1;EFA05073.1;EFA08151.1;EFA11530.1;EFA09425.1 Reactome: R-HSA-5654726 Negative regulation of FGFR1 signaling 4 KYB29360.1;KYB29359.1;EFA02110.1;EFA10708.1 Reactome: R-HSA-264876 Insulin processing 10 EEZ98592.2;EFA08867.1;EFA08190.1;EEZ97223.1;EFA08819.1;EEZ97195.1;EFA11086.1;EFA06250.1;EFA11035.1;EFA04473.2 Reactome: R-HSA-5358346 Hedgehog ligand biogenesis 43 KYB26545.1;KYB29359.1;EFA05912.1;EFA07110.1;EEZ99004.1;EFA05833.1;KYB24713.1;EFA04284.1;KYB25309.1;EFA05370.2;EEZ97564.1;EFA07261.2;EFA04054.1;EFA05865.1;EFA09524.2;EFA08798.1;EFA08601.1;EFA05871.2;EFA07659.2;EFA09518.2;EEZ98185.1;EFA02331.1;EFA03019.1;EFA05105.1;EFA07465.1;KYB27556.1;EEZ97876.1;KYB28973.1;KYB26764.1;EFA03341.1;EFA11079.1;EFA06519.1;EFA06741.1;EFA06200.1;EEZ97851.1;EFA08664.1;EFA02110.1;KYB29360.1;KYB27557.1;EFA08911.2;EFA02345.1;EFA13218.1;EEZ99493.1 Reactome: R-HSA-167243 Tat-mediated HIV elongation arrest and recovery 21 KYB25152.1;EFA05226.1;EFA10605.2;EFA06560.1;KYB26001.1;EFA03150.1;EFA03550.1;EFA08590.1;EFA07148.1;EFA00397.1;EFA05446.1;EFA05896.1;KYB25207.1;KYB28470.1;EEZ97398.2;EFA07031.1;EFA00606.1;EFA00603.1;EFA12997.1;EFA10288.1;EFA04061.1 KEGG: 04658+3.1.3.16 Th1 and Th2 cell differentiation 39 EFA07329.1;KYB28159.1;EFA07805.1;EFA04777.2;EFA00145.2;EFA05539.2;KYB28443.1;EFA10433.2;EEZ99522.2;KYB28233.1;EFA02685.2;EFA10861.1;EFA05189.1;EFA03763.1;KYB25565.1;EFA02473.2;KYB27758.1;EFA09896.1;KYB26880.1;EFA04151.1;KYB27757.1;KYB25190.1;EEZ97359.1;EFA08945.1;EFA11234.1;EFA10810.2;KYB25187.1;KYB28676.1;KYB28792.1;KYB27031.1;EFA00642.2;EFA01582.2;EFA04890.1;EFA07148.1;KYB25189.1;KYB28677.1;EFA06120.1;EFA13210.1;EFA03107.1 Reactome: R-HSA-8866652 Synthesis of active ubiquitin: roles of E1 and E2 enzymes 4 KYB29359.1;EFA02110.1;EFA07762.1;KYB29360.1 MetaCyc: PWY-5913 Partial TCA cycle (obligate autotrophs) 14 EFA10595.2;KYB27212.1;EFA03109.1;EFA04299.1;EFA09539.1;EFA03144.1;EFA03750.1;EFA07160.1;EFA04122.1;EFA05014.1;EFA04972.1;EFA11129.1;EFA11202.1;EFA02482.1 Reactome: R-HSA-2161541 Abacavir metabolism 1 EFA11497.1 Reactome: R-HSA-6802948 Signaling by high-kinase activity BRAF mutants 3 EFA10708.1;KYB26173.1;EFA08276.1 Reactome: R-HSA-5467348 Truncations of AMER1 destabilize the destruction complex 4 KYB26642.1;EFA13272.2;EFA05992.2;KYB26383.1 Reactome: R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol 137 EFA02257.1;EFA03236.1;EFA11360.1;EEZ98806.1;EFA07025.1;EFA01765.1;EFA10173.2;KYB29360.1;EFA05803.1;EEZ98503.1;EEZ98265.1;EFA06004.1;EFA03458.1;KYB27240.1;EFA00066.1;EFA04159.1;KYB26424.1;EFA04998.2;KYB29621.1;KXZ75826.1;EFA09390.1;EEZ98852.1;EFA07317.1;EFA05408.1;EEZ97645.1;KYB27481.1;EFA12204.1;EEZ98848.1;EFA13316.1;EFA00163.1;EFA05471.1;EFA08649.2;EFA01805.1;EFA02110.1;EFA09884.1;EFA00505.1;EEZ97313.1;EFA06382.1;EFA10201.2;EFA07181.2;EFA00935.2;EFA03533.1;EFA06341.1;EFA08624.1;EFA10126.1;EFA12491.1;EFA07752.1;EFA07437.1;KYB27567.1;EFA04808.1;EEZ98728.1;EFA03339.1;EFA01731.1;EEZ98784.1;EFA13254.1;EFA05246.1;EEZ99099.1;EFA04946.1;EFA02145.1;EFA08288.1;EFA05170.2;EFA06534.1;EFA08646.1;EFA10462.1;EFA10183.1;EEZ97360.2;EFA01958.1;EFA13378.1;EFA02592.1;EFA03441.1;EFA06414.1;EFA09345.2;EFA09871.1;EFA06999.1;EFA03478.1;EFA02123.1;KYB27741.1;EFA05884.1;EEZ98858.1;EFA05373.1;EEZ99918.1;EEZ99023.1;EFA00915.1;KYB27801.1;EFA11293.1;EFA06447.1;EFA09970.1;EFA06035.2;EFA12725.1;EFA00769.1;EFA03166.1;EFA00063.1;EFA10969.1;EFA02554.1;EFA01051.1;EFA00102.1;EFA03774.2;KYB28065.1;EFA06899.2;EEZ98071.1;EFA00147.1;EFA04120.1;EFA05867.1;EFA07030.1;EFA11837.1;EFA01004.2;KYB27157.1;EFA10478.1;EFA00178.1;EFA08849.1;EFA08168.1;KYB28440.1;EEZ97412.1;EEZ99856.2;EFA07836.1;EFA08054.1;EFA02571.1;EFA03295.1;EEZ97926.2;EFA02992.1;EFA08719.1;EFA09212.1;EFA01121.1;EFA06574.1;EFA01562.1;EFA09067.1;EEZ99757.1;EFA03346.1;EFA02268.1;EFA03398.1;EFA07141.1;EFA10479.1;EFA04453.1;KYB26522.1;KYB29359.1;EEZ97379.1;EFA10489.1 MetaCyc: PWY-5480 Pyruvate fermentation to ethanol I 1 EEZ98950.2 MetaCyc: PWY-5751 Phenylethanol biosynthesis 1 EEZ98950.2 KEGG: 00260+1.1.1.1 Glycine, serine and threonine metabolism 1 EEZ98950.2 Reactome: R-HSA-5467337 APC truncation mutants have impaired AXIN binding 4 EFA05992.2;KYB26383.1;KYB26642.1;EFA13272.2 Reactome: R-HSA-165181 Inhibition of TSC complex formation by PKB 2 EFA09042.2;EFA00138.1 KEGG: 00760+2.7.1.23 Nicotinate and nicotinamide metabolism 2 KYB26619.1;EFA08909.2 MetaCyc: PWY-6483 Ceramide degradation (generic) 3 EEZ97352.2;EEZ97353.1;EEZ97351.1 Reactome: R-HSA-416482 G alpha (12/13) signalling events 19 KYB25344.1;KYB28880.1;KYB27183.1;KXZ75737.1;EFA04406.2;KYB27184.1;KYB28883.1;EFA06518.2;KYB25864.1;KXZ75736.1;EFA00242.2;KXZ75734.1;EFA11099.2;KYB24949.1;EEZ97169.2;EFA08973.1;KYB28884.1;KYB27402.1;KYB28879.1 KEGG: 00970+6.1.1.1 Aminoacyl-tRNA biosynthesis 2 KYB26031.1;EFA03247.1 MetaCyc: PWY-5891 Menaquinol-11 biosynthesis 2 EFA05173.2;KYB27131.1 MetaCyc: PWY-46 Putrescine biosynthesis III 1 EFA03145.1 Reactome: R-HSA-9013507 NOTCH3 Activation and Transmission of Signal to the Nucleus 12 EFA10954.1;KYB27078.1;EFA04103.1;EFA02110.1;KYB29359.1;EFA07122.1;EFA05049.2;EFA07178.2;EFA03528.1;KYB29360.1;KYB27259.1;KYB26560.1 Reactome: R-HSA-77288 mitochondrial fatty acid beta-oxidation of unsaturated fatty acids 1 EFA04382.1 KEGG: 00072+2.3.3.10 Synthesis and degradation of ketone bodies 1 EFA06304.1 MetaCyc: PWY-7560 Methylerythritol phosphate pathway II 2 EFA07280.1;EFA11181.1 Reactome: R-HSA-6784531 tRNA processing in the nucleus 38 KYB29624.1;KYB27240.1;EFA10538.1;EFA11141.2;EFA09537.1;KYB27157.1;EFA00605.1;EFA00581.2;EFA03584.1;EEZ97868.2;KYB27036.1;EFA03300.1;KYB29271.1;EFA07823.1;KYB28401.1;EFA08615.2;EFA01249.2;EFA08240.1;KYB28630.1;EFA04039.1;EFA04928.2;EFA03311.1;EFA09019.1;EFA05993.1;KYB28730.1;KYB26428.1;EEZ99511.2;EFA11447.2;EFA09424.1;EFA11371.2;EFA06191.2;KYB29364.1;EFA10388.1;KYB26522.1;EFA08711.2;EFA03859.1;EFA01782.2;EEZ98695.2 Reactome: R-HSA-1632852 Macroautophagy 33 KYB27426.1;EFA07964.1;EEZ99675.1;EFA03061.1;EFA02668.2;EFA07410.1;KYB25457.1;EFA09042.2;EFA08847.1;KYB25771.1;EFA02004.1;KYB25772.1;KYB27425.1;EFA05182.1;EEZ99590.2;EFA11495.1;EEZ99978.2;EEZ98191.1;EFA03288.1;KYB29638.1;EFA09095.1;EFA05804.2;EFA02034.1;EFA09734.2;EEZ98297.1;EFA10325.2;EFA09480.2;EFA12722.1;EFA03165.2;EFA00138.1;EFA03418.1;KYB26892.1;EFA03068.1 Reactome: R-HSA-202733 Cell surface interactions at the vascular wall 9 KYB29705.1;KYB29706.1;KYB26997.1;EFA11584.2;KYB29704.1;EFA03106.1;EFA11302.1;EFA11378.1;EFA11425.1 MetaCyc: PWY-7727 Docosahexaenoate biosynthesis IV (4-desaturase, mammals) 2 EFA05143.1;EFA03551.1 Reactome: R-HSA-2162123 Synthesis of Prostaglandins (PG) and Thromboxanes (TX) 1 EFA00341.1 Reactome: R-HSA-77285 Beta oxidation of myristoyl-CoA to lauroyl-CoA 1 EFA04382.1 KEGG: 00030+2.7.1.15 Pentose phosphate pathway 1 EFA08820.2 KEGG: 00380+4.2.1.17 Tryptophan metabolism 1 EFA04382.1 KEGG: 00720+6.4.1.1 Carbon fixation pathways in prokaryotes 1 KYB27787.1 Reactome: R-HSA-9013508 NOTCH3 Intracellular Domain Regulates Transcription 4 EFA02517.2;EEZ99094.1;EFA04470.1;EEZ99435.2 KEGG: 00750+2.7.1.35 Vitamin B6 metabolism 1 EFA00408.1 Reactome: R-HSA-5579006 Defective GSS causes Glutathione synthetase deficiency (GSS deficiency) 2 EFA06495.2;EFA06494.1 Reactome: R-HSA-1442490 Collagen degradation 15 EFA04092.2;KYB29308.1;EFA09154.2;EFA09264.2;EFA00883.1;EFA01288.1;KYB29228.1;EEZ98535.2;KYB25044.1;EFA01286.1;KYB27188.1;EFA01289.1;EFA01287.1;EFA04342.1;EFA09153.1 Reactome: R-HSA-212676 Dopamine Neurotransmitter Release Cycle 8 EEZ99137.2;EFA12118.1;KXZ75660.1;KXZ75661.1;KYB29537.1;KYB29538.1;EEZ99659.1;KYB29539.1 KEGG: 00640+1.1.1.27 Propanoate metabolism 1 EFA01008.1 Reactome: R-HSA-5619061 Defective SLC33A1 causes spastic paraplegia 42 (SPG42) 1 EFA08955.1 MetaCyc: PWY-7927 Sulfide oxidation IV (mitochondria) 1 EFA06486.2 KEGG: 00720+1.1.1.37 Carbon fixation pathways in prokaryotes 2 EFA04972.1;EFA02482.1 KEGG: 00020+4.1.1.32 Citrate cycle (TCA cycle) 2 KYB26254.1;EFA06223.2 KEGG: 00230+1.7.1.7 Purine metabolism 1 EFA06520.1 MetaCyc: PWY-7279 Aerobic respiration II (cytochrome c) (yeast) 6 EFA09226.1;EFA01233.1;EFA04683.1;EEZ97735.1;EFA10709.2;EFA02829.1 Reactome: R-HSA-3108214 SUMOylation of DNA damage response and repair proteins 33 KYB27483.1;EFA11447.2;EFA11876.2;EFA05993.1;KYB26512.1;EEZ98695.2;KYB26388.1;EEZ97230.1;EFA01782.2;EFA03859.1;EFA05994.1;KYB29364.1;EEZ97760.2;EEZ97868.2;EFA03584.1;EFA12891.1;KYB24996.1;EFA00581.2;EFA00605.1;EFA11141.2;EFA09537.1;KYB29624.1;EFA00829.2;EFA04928.2;EFA09584.2;KYB28630.1;EFA01249.2;KYB28401.1;KYB29271.1;EEZ98330.2;EFA07823.1;KYB26425.1;EFA09711.2 MetaCyc: PWY-4984 Urea cycle 3 EFA11668.2;EEZ97516.1;EFA03145.1 MetaCyc: PWY-7401 Crotonate fermentation (to acetate and cyclohexane carboxylate) 3 EFA05073.1;EFA08151.1;EFA04382.1 Reactome: R-HSA-5666185 RHO GTPases Activate Rhotekin and Rhophilins 1 EFA11159.2 KEGG: 00860+4.2.1.24 Porphyrin and chlorophyll metabolism 1 EFA07026.1 Reactome: R-HSA-5358493 Synthesis of diphthamide-EEF2 4 EFA02050.1;EFA04256.2;EEZ99477.1;EFA05560.1 Reactome: R-HSA-9009391 Extra-nuclear estrogen signaling 2 KYB25864.1;KYB29656.1 Reactome: R-HSA-5632928 Defective Mismatch Repair Associated With MSH2 3 EFA11424.2;EFA12365.1;EFA10321.2 KEGG: 00240+2.7.4.9 Pyrimidine metabolism 2 EFA08206.2;EFA00847.2 Reactome: R-HSA-189200 Cellular hexose transport 48 EFA01663.1;EFA05603.2;EFA12961.1;KYB29810.1;EFA10060.1;EFA10111.2;EFA10058.1;EFA10054.1;EFA06747.1;KYB28667.1;EFA03570.2;EFA00433.1;EFA10055.1;KYB26540.1;KYB27138.1;KYB25889.1;KYB25476.1;KYB25426.1;EFA00382.1;KYB26935.1;KYB26936.1;EFA10059.1;EFA10056.1;EFA06748.1;EFA04079.1;EEZ99539.1;EFA05276.2;EFA04827.1;EFA00434.1;EFA09565.2;KYB25661.1;EFA04822.2;EFA10574.1;EFA12963.1;EFA00435.2;KYB25775.1;EFA10347.1;EFA04753.1;KYB27009.1;EFA10597.2;EFA06749.1;KYB27182.1;EFA10061.1;KYB25776.1;EFA12962.1;EFA10112.2;EFA03487.1;EFA10110.1 KEGG: 00230+2.7.4.6+2.7.4.3 Purine metabolism 1 EFA03917.1 Reactome: R-HSA-9615017 FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes 4 EFA09191.1;EEZ97738.1;EEZ97708.2;KYB28799.1 KEGG: 00030+2.7.1.11 Pentose phosphate pathway 2 EFA08228.2;KYB26002.1 Reactome: R-HSA-5673001 RAF/MAP kinase cascade 11 EEZ99807.2;KYB28360.1;KYB29108.1;EFA11039.2;EEZ99233.1;EFA09715.1;EFA01355.2;KYB29693.1;EFA10708.1;EFA01607.2;EFA09507.1 KEGG: 00564+3.1.1.32 Glycerophospholipid metabolism 2 EFA11061.1;EFA11062.1 KEGG: 00710+2.7.2.3 Carbon fixation in photosynthetic organisms 1 EFA05374.1 Reactome: R-HSA-3656535 TGFBR1 LBD Mutants in Cancer 2 EEZ97734.1;EFA07576.2 KEGG: 00970+6.1.1.19 Aminoacyl-tRNA biosynthesis 2 EFA00823.2;EFA01911.1 Reactome: R-HSA-2559584 Formation of Senescence-Associated Heterochromatin Foci (SAHF) 1 KYB28452.1 Reactome: R-HSA-1253288 Downregulation of ERBB4 signaling 3 KYB29360.1;KYB29359.1;EFA02110.1 Reactome: R-HSA-77289 Mitochondrial Fatty Acid Beta-Oxidation 6 KYB25738.1;EFA04161.2;KYB25739.1;EEZ97323.1;EEZ97354.1;EEZ97355.1 Reactome: R-HSA-2468052 Establishment of Sister Chromatid Cohesion 3 EEZ99210.2;EEZ97230.1;EFA06803.2 Reactome: R-HSA-112311 Neurotransmitter clearance 4 EFA06763.1;EEZ99262.2;KYB26709.1;EFA04156.1 MetaCyc: PWY-5514 UDP-N-acetyl-D-galactosamine biosynthesis II 5 EFA09778.2;EFA02005.2;EFA00108.1;EFA08071.1;EFA07687.2 KEGG: 00970+6.1.1.10 Aminoacyl-tRNA biosynthesis 2 KYB25592.1;EFA06771.1 KEGG: 00220+4.3.2.1 Arginine biosynthesis 1 EFA11668.2 MetaCyc: PWY-6352 3-phosphoinositide biosynthesis 4 EFA00380.1;EFA09848.2;EFA05079.1;EEZ98191.1 KEGG: 00010+2.7.2.3 Glycolysis / Gluconeogenesis 1 EFA05374.1 KEGG: 00380+1.2.4.2 Tryptophan metabolism 4 EFA05916.2;EFA04760.2;EFA10391.1;KYB27599.1 MetaCyc: PWY-6952 Glycerophosphodiester degradation 2 EFA04316.2;KYB27335.1 MetaCyc: PWY-7198 Pyrimidine deoxyribonucleotides de novo biosynthesis IV 13 EFA02095.1;EFA02203.1;EFA02202.1;KYB29374.1;KYB26165.1;EFA07171.1;EFA08206.2;EEZ98594.1;EFA11748.1;EFA03917.1;EFA00847.2;EEZ99726.1;EFA03825.1 KEGG: 00254+6.4.1.2 Aflatoxin biosynthesis 1 EFA05436.2 Reactome: R-HSA-167160 RNA Pol II CTD phosphorylation and interaction with CE during HIV infection 20 KYB26001.1;EFA06560.1;EFA03550.1;EFA03004.2;EFA03150.1;KYB25152.1;EFA05226.1;KYB25378.1;EFA05896.1;EFA05446.1;EFA00328.1;EEZ97398.2;EFA07031.1;EFA03427.1;EFA06469.1;EFA00018.1;KYB28470.1;EFA02310.1;EFA07055.2;EFA07302.1 Reactome: R-HSA-936440 Negative regulators of DDX58/IFIH1 signaling 8 EFA00919.1;KYB29360.1;EFA07517.1;EFA06854.1;EFA02034.1;KYB29359.1;EFA02110.1;EEZ98297.1 MetaCyc: PWY-622 Starch biosynthesis 9 KYB29170.1;EFA11030.1;EEZ98450.1;EFA07687.2;EEZ98454.1;EEZ98452.1;EEZ98451.1;EEZ98206.2;KYB29169.1 Reactome: R-HSA-388841 Costimulation by the CD28 family 2 KYB29656.1;EFA12064.1 Reactome: R-HSA-8851708 Signaling by FGFR2 IIIa TM 12 EFA05896.1;EEZ98143.1;EEZ98144.2;EFA06560.1;KYB26001.1;EEZ97398.2;EFA03150.1;EFA07031.1;EFA03550.1;KYB25152.1;EFA05226.1;KYB28470.1 KEGG: 00020+6.2.1.4 Citrate cycle (TCA cycle) 1 EFA11202.1 MetaCyc: PWY-8047 Bryostatin biosynthesis 7 EFA05248.1;EEZ97866.2;EFA11365.1;EFA05249.2;EFA05201.1;EFA05204.2;EFA05203.2 KEGG: 00250+2.1.3.2 Alanine, aspartate and glutamate metabolism 1 EFA10197.1 Reactome: R-HSA-9031525 NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake 1 EFA06019.1 MetaCyc: PWY-5340 Sulfate activation for sulfonation 1 EFA13134.1 Reactome: R-HSA-114604 GPVI-mediated activation cascade 6 EEZ97169.2;KYB29656.1;EFA12064.1;KYB24949.1;EFA03253.1;EFA00152.1 KEGG: 00534+2.4.2.26 Glycosaminoglycan biosynthesis - heparan sulfate / heparin 1 EFA12734.1 Reactome: R-HSA-8878166 Transcriptional regulation by RUNX2 2 KYB27618.1;EFA03630.2 Reactome: R-HSA-5657655 MGMT-mediated DNA damage reversal 1 EFA05409.1 MetaCyc: PWY-7388 Octanoyl-[acyl-carrier protein] biosynthesis (mitochondria, yeast) 7 EEZ97866.2;EFA11365.1;EFA05248.1;EFA05203.2;EFA05201.1;EFA05249.2;EFA05204.2 Reactome: R-HSA-111447 Activation of BAD and translocation to mitochondria 3 EFA08461.1;EFA11005.2;EFA02105.1 KEGG: 00630+6.4.1.3 Glyoxylate and dicarboxylate metabolism 1 EFA03463.2 Reactome: R-HSA-1660661 Sphingolipid de novo biosynthesis 10 EFA05646.1;EFA03044.1;KXZ75838.1;KXZ75837.1;EFA06812.1;KYB26446.1;KYB25244.1;EFA08405.2;KYB26252.1;EFA06537.1 KEGG: 00230+3.5.4.6 Purine metabolism 3 EFA06084.2;KYB26469.1;KYB26470.1 MetaCyc: PWY-7466 Acetone degradation III (to propane-1,2-diol) 1 EFA05733.1 KEGG: 00240+3.6.1.6 Pyrimidine metabolism 1 EFA07795.2 KEGG: 00051+4.2.1.68 Fructose and mannose metabolism 1 EFA10251.2 Reactome: R-HSA-2142691 Synthesis of Leukotrienes (LT) and Eoxins (EX) 7 EFA06407.2;EEZ99578.1;KYB27245.1;EFA06410.1;EFA08612.1;KYB27246.1;KYB26848.1 Reactome: R-HSA-264642 Acetylcholine Neurotransmitter Release Cycle 4 KYB29538.1;EEZ99137.2;KYB29537.1;KYB29539.1 Reactome: R-HSA-428540 Activation of RAC1 3 EFA03699.2;EFA02342.2;EFA03058.1 KEGG: 00230+2.4.2.14 Purine metabolism 2 EEZ98112.1;EEZ97659.2 Reactome: R-HSA-432720 Lysosome Vesicle Biogenesis 5 EFA02270.2;EFA09960.1;EFA09116.1;EFA04898.1;EFA10392.1 Reactome: R-HSA-113418 Formation of the Early Elongation Complex 27 EFA00397.1;EFA07148.1;EFA00328.1;EFA05896.1;EFA05446.1;KYB25207.1;KYB25152.1;EFA05226.1;KYB25378.1;EFA06560.1;KYB26001.1;EFA03550.1;EFA08590.1;EFA03150.1;EEZ98144.2;EEZ98143.1;EFA02310.1;EFA07055.2;EFA10288.1;EFA07302.1;EFA06469.1;KYB28470.1;EFA00018.1;EEZ97398.2;EFA00606.1;EFA00603.1;EFA07031.1 KEGG: 00564+2.3.1.15 Glycerophospholipid metabolism 2 EFA06119.2;EFA09975.1 MetaCyc: PWY-4361 S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation I 7 EFA12261.1;EFA02518.1;EEZ99144.1;EFA12349.2;EEZ99138.2;EEZ97197.1;EFA07698.1 Reactome: R-HSA-5576893 Phase 2 - plateau phase 17 KYB27418.1;KYB29721.1;KYB27419.1;EFA11116.2;KYB29722.1;EEZ97400.2;KYB29718.1;KYB25145.1;KYB25144.1;KYB27055.1;KYB29565.1;KYB29717.1;KYB29719.1;EFA11006.2;EFA12820.2;EFA02558.2;KYB29720.1 KEGG: 00020+1.2.4.1 Citrate cycle (TCA cycle) 2 EFA00070.1;EFA00132.1 KEGG: 00010+5.4.2.11 Glycolysis / Gluconeogenesis 2 EFA11310.1;EEZ98809.1 MetaCyc: PWY-7003 Glycerol degradation to butanol 14 EFA08842.1;EFA01748.1;EFA05374.1;EFA08517.1;KYB24935.1;EFA07763.1;EEZ99016.2;KYB25941.1;EFA09610.1;EEZ97193.2;EFA09609.1;EFA10506.1;EFA08832.2;KYB24934.1 Reactome: R-HSA-5632987 Defective Mismatch Repair Associated With PMS2 1 EFA08028.2 KEGG: 00720+6.4.1.2 Carbon fixation pathways in prokaryotes 1 EFA05436.2 KEGG: 00561+2.7.1.30 Glycerolipid metabolism 6 EEZ98930.1;EFA00308.1;EEZ99510.1;EEZ99630.1;EFA09750.1;EFA06784.1 Reactome: R-HSA-450302 activated TAK1 mediates p38 MAPK activation 5 KYB29359.1;EFA02110.1;EFA11394.1;KYB29360.1;EFA02851.1 KEGG: 00564+2.7.1.107 Glycerophospholipid metabolism 11 EFA08801.2;KYB25925.1;KYB29060.1;EFA03802.2;KYB29048.1;KYB26617.1;KYB26618.1;KYB29049.1;KYB29047.1;KYB29061.1;EEZ98328.2 Reactome: R-HSA-4641263 Regulation of FZD by ubiquitination 3 KYB29360.1;EFA02110.1;KYB29359.1 Reactome: R-HSA-71240 Tryptophan catabolism 3 EFA06898.1;EEZ98408.1;EFA02356.1 KEGG: 00860+6.1.1.17 Porphyrin and chlorophyll metabolism 3 KYB26720.1;EFA03776.2;KYB27531.1 KEGG: 00230+3.6.1.66 Purine metabolism 1 EFA03919.1 Reactome: R-HSA-909733 Interferon alpha/beta signaling 2 EFA12064.1;EFA01192.1 Reactome: R-HSA-9665244 Resistance of ERBB2 KD mutants to sapitinib 1 EFA03198.1 KEGG: 00590+1.14.14.1 Arachidonic acid metabolism 1 EFA05733.1 Reactome: R-HSA-4549349 Defective ALG2 causes ALG2-CDG (CDG-1i) 2 EFA00652.1;EFA03871.1 Reactome: R-HSA-9018519 Estrogen-dependent gene expression 26 EFA06253.1;KYB26000.1;KYB25999.1;EFA02517.2;EEZ97230.1;EFA11590.1;EFA05896.1;EFA05226.1;EFA04626.2;KYB25152.1;EFA03150.1;EFA03550.1;KYB26001.1;EFA08558.1;EEZ97347.1;EFA06560.1;EFA10996.1;KYB25778.1;EFA08972.2;KYB27618.1;KYB28470.1;EFA07031.1;EFA03630.2;EFA09197.2;KYB24563.1;EEZ97398.2 Reactome: R-HSA-3232142 SUMOylation of ubiquitinylation proteins 20 EFA00581.2;EFA03584.1;EFA11447.2;EEZ97868.2;EFA07468.1;KYB29624.1;EFA09537.1;EFA11141.2;EFA00605.1;EFA05993.1;EEZ98695.2;KYB28630.1;EFA04928.2;KYB29364.1;EFA07823.1;KYB29271.1;EFA03859.1;KYB28401.1;EFA01249.2;EFA01782.2 Reactome: R-HSA-5696395 Formation of Incision Complex in GG-NER 20 KYB29359.1;EFA03569.1;EFA05994.1;EFA09711.2;EFA00328.1;EFA03362.2;EFA00829.2;KYB25378.1;EFA07055.2;EFA02110.1;EFA02310.1;EFA07302.1;KYB27483.1;KYB29360.1;EEZ97282.2;EFA06469.1;EFA12891.1;EFA09906.2;EFA00018.1;KYB26998.1 Reactome: R-HSA-6804759 Regulation of TP53 Activity through Association with Co-factors 3 EFA02105.1;EFA12882.1;EFA12881.2 Reactome: R-HSA-159740 Gamma-carboxylation of protein precursors 1 EFA03079.2 KEGG: 00330+1.2.1.41 Arginine and proline metabolism 1 EEZ98981.2 Reactome: R-HSA-77595 Processing of Intronless Pre-mRNAs 10 KYB26428.1;EEZ97191.2;EFA12938.2;EEZ98144.2;EEZ98143.1;KYB26686.1;EFA03141.1;KYB27333.1;EFA02993.1;EFA07272.1 Reactome: R-HSA-532668 N-glycan trimming in the ER and Calnexin/Calreticulin cycle 11 EFA06236.2;EEZ98119.2;EFA09821.2;KYB29360.1;EFA09314.2;KYB26414.1;KYB29359.1;EFA02110.1;KYB25099.1;EFA07465.1;EFA10323.1 Reactome: R-HSA-186797 Signaling by PDGF 3 KYB26199.1;KYB27188.1;EFA04092.2 KEGG: 00230+6.3.3.1 Purine metabolism 1 KYB25818.1 Reactome: R-HSA-204005 COPII-mediated vesicle transport 25 EFA12998.1;EFA06320.2;EFA01820.1;EFA00133.1;KYB27195.1;EFA08682.1;EFA10355.1;EFA11398.1;EFA12180.1;EFA02601.2;KYB24587.1;EFA12359.2;EFA03277.2;EFA01590.1;EFA02290.1;EFA06745.1;KYB25047.1;EFA06622.1;EFA04607.2;EFA03885.1;EFA12234.1;KYB25046.1;KYB25045.1;KYB26644.1;KYB25955.1 Reactome: R-HSA-8941858 Regulation of RUNX3 expression and activity 40 EFA03341.1;KYB27556.1;EEZ97876.1;EFA06200.1;EFA08664.1;EFA11079.1;EFA06519.1;EFA06741.1;EFA02110.1;EFA08911.2;EFA02345.1;EFA13218.1;EEZ99493.1;KYB29360.1;KYB27557.1;EFA05912.1;KYB29359.1;EFA07110.1;KYB26545.1;KYB25309.1;EFA04284.1;EFA05370.2;EEZ99004.1;EFA05833.1;KYB24713.1;EFA04054.1;EFA05865.1;EFA09524.2;EFA08798.1;EEZ97564.1;EEZ98185.1;EFA02331.1;EFA03019.1;EFA05105.1;EFA03630.2;EFA08601.1;KYB27618.1;EFA05871.2;EFA07659.2;EFA09518.2 Reactome: R-HSA-977225 Amyloid fiber formation 11 EEZ99723.1;KYB27078.1;EFA04103.1;EFA02110.1;KYB29359.1;EFA05049.2;KYB29360.1;EFA10119.2;KYB28295.1;EFA03872.2;KYB24563.1 Reactome: R-HSA-5660862 Defective SLC7A7 causes lysinuric protein intolerance (LPI) 1 EFA06898.1 KEGG: 00030+4.1.2.4 Pentose phosphate pathway 1 EFA12496.1 Reactome: R-HSA-3560801 Defective B3GAT3 causes JDSSDHD 3 EFA11584.2;KYB27316.1;EFA03369.2 MetaCyc: PWY-66 GDP-L-fucose biosynthesis I (from GDP-D-mannose) 1 EFA01082.1 MetaCyc: PWY-6012 Acyl carrier protein metabolism 1 EEZ97421.2 Reactome: R-HSA-5685939 HDR through MMEJ (alt-NHEJ) 7 EFA07487.1;EFA00829.2;KYB29442.1;EFA04568.2;EFA06383.1;EEZ98905.1;EFA05681.1 Reactome: R-HSA-382556 ABC-family proteins mediated transport 47 EFA07465.1;EEZ97876.1;KYB27556.1;KYB26764.1;EFA03341.1;EFA11079.1;EFA08527.1;EFA06519.1;EFA06741.1;EFA06200.1;EEZ97851.1;EFA08664.1;EFA02110.1;KYB29360.1;EFA08946.1;KYB27557.1;EFA08911.2;EFA13218.1;EFA02345.1;EEZ99493.1;KYB26545.1;EFA06805.1;EFA07164.1;EFA05912.1;KYB29359.1;EFA07110.1;KYB25508.1;EEZ99004.1;EFA05833.1;KYB24713.1;EFA04284.1;KYB25309.1;EFA05370.2;EEZ97564.1;EFA07261.2;EFA05865.1;EFA04054.1;EFA09524.2;EFA08798.1;EFA08601.1;EFA05871.2;EFA07659.2;EFA09518.2;EFA02331.1;EEZ98185.1;EFA03019.1;EFA05105.1 Reactome: R-HSA-5358747 S33 mutants of beta-catenin aren't phosphorylated 4 KYB26642.1;EFA13272.2;EFA05992.2;KYB26383.1 MetaCyc: PWY-6470 Peptidoglycan biosynthesis V (beta-lactam resistance) 3 KYB27827.1;EFA02198.2;EEZ98644.1 MetaCyc: PWY-7197 Pyrimidine deoxyribonucleotide phosphorylation 7 EFA03917.1;EEZ98594.1;EFA08206.2;EEZ99726.1;EFA07171.1;KYB26165.1;EFA00847.2 MetaCyc: PWY-7221 Guanosine ribonucleotides de novo biosynthesis 15 EFA03917.1;EFA09313.1;EEZ98391.1;EEZ99726.1;EFA11857.1;KYB27803.1;KYB28746.1;EEZ99889.2;KYB27802.1;EFA00746.2;EFA07171.1;KYB26165.1;KYB27658.1;EFA11497.1;EEZ98594.1 Reactome: R-HSA-5696394 DNA Damage Recognition in GG-NER 14 KYB25639.1;EEZ97220.1;EFA09688.1;EFA12663.1;EFA05994.1;EFA08119.1;EFA02110.1;EFA01675.1;KYB29359.1;KYB26998.1;KYB29360.1;EFA00829.2;KYB28049.1;EFA00828.1 MetaCyc: PWY-3341 L-proline biosynthesis III (from L-ornithine) 4 EFA12217.1;EFA00672.1;EEZ98115.1;EEZ98116.1 MetaCyc: PWY-5971 Palmitate biosynthesis II (bacteria and plant cytoplasm) 7 EFA05203.2;EFA05204.2;EFA05201.1;EFA05249.2;EEZ97866.2;EFA11365.1;EFA05248.1 Reactome: R-HSA-192456 Digestion of dietary lipid 2 EFA10312.1;KYB25598.1 Reactome: R-HSA-5205685 Pink/Parkin Mediated Mitophagy 11 KYB28050.1;EEZ98297.1;EFA10229.1;KYB25576.1;EFA05442.2;KYB29359.1;EFA02110.1;EFA02034.1;EFA03872.2;KYB29360.1;EFA09534.1 Reactome: R-HSA-5362768 Hh mutants that don't undergo autocatalytic processing are degraded by ERAD 42 EFA02110.1;EFA08911.2;EFA02345.1;EFA13218.1;EEZ99493.1;KYB29360.1;KYB27557.1;KYB26764.1;EFA03341.1;EFA07465.1;KYB27556.1;EEZ97876.1;EFA06200.1;EEZ97851.1;EFA08664.1;EFA11079.1;EFA06519.1;EFA06741.1;EFA05865.1;EFA04054.1;EFA09524.2;EFA08798.1;EEZ97564.1;EFA07261.2;EFA02331.1;EEZ98185.1;EFA03019.1;EFA05105.1;EFA08601.1;EFA07659.2;EFA05871.2;EFA09518.2;KYB29359.1;EFA05912.1;EFA07110.1;KYB26545.1;KYB25309.1;EFA04284.1;EFA05370.2;EFA05833.1;EEZ99004.1;KYB24713.1 MetaCyc: PWY-7255 Ergothioneine biosynthesis I (bacteria) 1 EFA04528.1 Reactome: R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling 1 EFA05853.2 KEGG: 00030+1.1.1.44 Pentose phosphate pathway 1 EFA03025.1 KEGG: 00592+1.1.1.1 alpha-Linolenic acid metabolism 1 EEZ98950.2 KEGG: 00330+3.5.3.1 Arginine and proline metabolism 1 EFA03145.1 Reactome: R-HSA-418457 cGMP effects 6 EFA04087.1;KYB25935.1;KYB25934.1;EFA12840.1;KYB25936.1;KYB27319.1 Reactome: R-HSA-500657 Presynaptic function of Kainate receptors 2 KYB27786.1;KYB25864.1 KEGG: 00190+7.1.2.2 Oxidative phosphorylation 4 EFA07428.1;EFA05714.1;EFA10717.1;EFA02908.1 MetaCyc: PWY-7233 Ubiquinol-6 bypass biosynthesis (eukaryotic) 2 KYB26214.1;EFA04400.1 Reactome: R-HSA-9665233 Resistance of ERBB2 KD mutants to trastuzumab 1 EFA03198.1 Reactome: R-HSA-8850843 Phosphate bond hydrolysis by NTPDase proteins 1 EFA02346.1 KEGG: 00330+2.5.1.16 Arginine and proline metabolism 2 EFA05567.1;EFA05082.1 Reactome: R-HSA-1483213 Synthesis of PE 3 KYB29477.1;EFA07054.2;KYB26367.1 MetaCyc: PWY-5857 Ubiquinol-10 biosynthesis (prokaryotic) 3 KYB26307.1;KYB26214.1;EFA04400.1 Reactome: R-HSA-113501 Inhibition of replication initiation of damaged DNA by RB1/E2F1 5 EFA07996.1;EFA09576.1;EFA10435.1;EFA04623.2;EFA07750.2 MetaCyc: PWY-5642 2,4-dinitrotoluene degradation 1 KYB27796.1 Reactome: R-HSA-174490 Membrane binding and targetting of GAG proteins 8 EEZ97653.2;EEZ99668.1;EFA03761.1;KYB29360.1;EFA04908.1;KYB29359.1;EFA02110.1;EFA07193.1 Reactome: R-HSA-168138 Toll Like Receptor 9 (TLR9) Cascade 2 EEZ98191.1;EFA06457.1 KEGG: 04070+3.1.3.25 Phosphatidylinositol signaling system 2 EFA12936.1;KYB25020.1 MetaCyc: PWY-7179-1 Purine deoxyribonucleosides degradation II 4 EFA01001.1;EFA03250.2;EFA00425.1;EFA00339.1 Reactome: R-HSA-8949275 RUNX3 Regulates Immune Response and Cell Migration 2 KYB27618.1;EFA03630.2 Reactome: R-HSA-3065678 SUMO is transferred from E1 to E2 (UBE2I, UBC9) 1 EFA12146.1 KEGG: 00790+3.1.3.1 Folate biosynthesis 4 EFA01926.1;KYB26031.1;KYB25767.1;KYB29475.1 MetaCyc: PWY-7007 Methyl ketone biosynthesis (engineered) 6 EFA11530.1;EFA09425.1;EFA08151.1;EFA05073.1;EFA09569.1;EFA04382.1 Reactome: R-HSA-5362517 Signaling by Retinoic Acid 3 EFA00132.1;EFA06557.2;EFA00070.1 Reactome: R-HSA-349425 Autodegradation of the E3 ubiquitin ligase COP1 41 EFA06519.1;EFA11079.1;EFA06741.1;EFA06200.1;EFA08664.1;EEZ97876.1;KYB27556.1;EFA03341.1;KYB26764.1;KYB29360.1;KYB27557.1;EFA02345.1;EFA13218.1;EFA08911.2;EEZ99493.1;EFA02110.1;KYB24713.1;EFA05833.1;EEZ99004.1;KYB25309.1;EFA04284.1;EFA05370.2;KYB26545.1;EFA11787.2;KYB29359.1;EFA05912.1;EFA07110.1;EFA08601.1;EFA09518.2;EFA05871.2;EFA07659.2;EEZ98185.1;EFA02331.1;EFA05105.1;EFA03019.1;EFA07261.2;EEZ97564.1;EFA05865.1;EFA04054.1;EFA08798.1;EFA09524.2 MetaCyc: PWY-381 Nitrate reduction II (assimilatory) 2 EEZ99821.1;EEZ97848.1 KEGG: 00600+3.5.1.23 Sphingolipid metabolism 3 EEZ97352.2;EEZ97353.1;EEZ97351.1 KEGG: 00230+2.7.1.20 Purine metabolism 4 KYB25746.1;EFA08050.1;EFA07316.1;KYB25745.1 MetaCyc: PWY-5531 3,8-divinyl-chlorophyllide a biosynthesis II (anaerobic) 1 KYB29726.1 KEGG: 00521+3.1.3.25 Streptomycin biosynthesis 2 EFA12936.1;KYB25020.1 KEGG: 00480+2.5.1.18+1.8.5.1 Glutathione metabolism 3 EEZ99480.1;EEZ99479.1;EFA00963.1 Reactome: R-HSA-192823 Viral mRNA Translation 74 EFA04120.1;EFA05471.1;EFA00163.1;EFA12204.1;EEZ97645.1;KYB27481.1;EFA01051.1;EFA02554.1;EFA09390.1;EFA10969.1;EFA03166.1;EEZ98852.1;EFA07317.1;EFA11293.1;KYB27801.1;KYB26424.1;EFA04159.1;EFA09970.1;KYB29621.1;EEZ99023.1;EFA05373.1;EFA03478.1;EFA03441.1;EFA09345.2;EEZ98858.1;KYB27741.1;EEZ98503.1;EFA02257.1;EFA03236.1;EFA11360.1;EFA10462.1;KYB29360.1;EFA02592.1;EFA10173.2;EFA05803.1;EEZ97360.2;EFA10183.1;EFA01765.1;KYB29359.1;EFA02145.1;EFA04453.1;EEZ97379.1;EFA06534.1;EFA05170.2;EFA03346.1;EFA02268.1;EEZ99099.1;EFA07141.1;EFA04946.1;EFA09067.1;EEZ98728.1;EFA01731.1;EFA13254.1;EFA09212.1;EFA06341.1;EFA08624.1;EFA06574.1;KYB27567.1;EFA03533.1;EFA02992.1;EFA00935.2;EEZ97412.1;EEZ97313.1;EFA06382.1;EFA10201.2;EFA08054.1;EFA02110.1;EFA11837.1;EFA08849.1;EFA08168.1;EFA00505.1;EFA07030.1;EFA05867.1;EFA01805.1 Reactome: R-HSA-4043916 Defective MPI causes MPI-CDG (CDG-1b) 1 EFA01794.1 Reactome: R-HSA-165054 Rev-mediated nuclear export of HIV RNA 22 EFA01782.2;EFA01249.2;KYB28401.1;EFA03859.1;EFA07823.1;KYB29271.1;KYB29364.1;EFA04928.2;KYB28630.1;EEZ98695.2;EFA05993.1;EFA00605.1;EFA00171.1;EFA10538.1;EFA11141.2;EFA09537.1;KYB29624.1;EFA11447.2;EEZ97868.2;EFA03584.1;EFA00581.2;EFA09995.1 KEGG: 00970+6.1.1.7 Aminoacyl-tRNA biosynthesis 3 KYB26355.1;EFA11359.1;EFA03148.1 Reactome: R-HSA-9648895 Response of EIF2AK1 (HRI) to heme deficiency 2 EFA07164.1;KYB27475.1 KEGG: 00790+4.2.1.96 Folate biosynthesis 1 EFA07130.1 KEGG: 00260+1.4.4.2 Glycine, serine and threonine metabolism 1 EFA01173.1 KEGG: 00051+5.3.1.8 Fructose and mannose metabolism 1 EFA01794.1 KEGG: 00230+3.5.4.10+2.1.2.3 Purine metabolism 1 EEZ98830.1 Reactome: R-HSA-917729 Endosomal Sorting Complex Required For Transport (ESCRT) 13 EFA07193.1;EFA04908.1;EFA03831.1;EFA06909.1;EFA02110.1;KYB29359.1;EEZ99668.1;KYB29360.1;EFA03761.1;EFA01867.1;EFA09116.1;EEZ97653.2;EFA02261.1 MetaCyc: PWY-5675 Nitrate reduction V (assimilatory) 2 EEZ99821.1;EEZ97848.1 Reactome: R-HSA-5678895 Defective CFTR causes cystic fibrosis 45 EFA02110.1;EEZ99493.1;EFA13218.1;EFA02345.1;EFA08911.2;KYB27557.1;EFA08946.1;KYB29360.1;EFA03341.1;KYB26764.1;EEZ97876.1;KYB27556.1;EFA07465.1;EFA08664.1;EEZ97851.1;EFA06200.1;EFA06741.1;EFA06519.1;EFA11079.1;EFA08527.1;EFA08798.1;EFA09524.2;EFA05865.1;EFA04054.1;EFA07261.2;EEZ97564.1;EFA05105.1;EFA03019.1;EFA02331.1;EEZ98185.1;EFA09518.2;EFA07659.2;EFA05871.2;EFA08601.1;EFA07110.1;KYB29359.1;EFA05912.1;EFA06805.1;KYB26545.1;EFA05370.2;EFA04284.1;KYB25309.1;KYB24713.1;EFA05833.1;EEZ99004.1 Reactome: R-HSA-446199 Synthesis of Dolichyl-phosphate 4 EFA03406.1;EEZ97509.1;EFA08584.1;EFA00378.2 KEGG: 00500+3.6.1.9 Starch and sucrose metabolism 2 EFA03919.1;EFA04414.1 KEGG: 00240+3.5.2.3 Pyrimidine metabolism 1 EFA10197.1 KEGG: 00790+1.14.16.1 Folate biosynthesis 1 EEZ99507.1 MetaCyc: PWY-7124 Ethylene biosynthesis V (engineered) 6 EFA10595.2;EFA09609.1;EFA10506.1;EFA04299.1;EFA09610.1;EFA09539.1 Reactome: R-HSA-913709 O-linked glycosylation of mucins 13 EFA02177.1;EFA06224.2;EFA05109.1;EFA07904.2;EFA01652.1;EFA04575.1;EFA08271.1;EFA02618.2;EFA08098.1;EFA02739.1;KYB25760.1;EFA02466.1;EEZ99809.1 KEGG: 00630+6.2.1.1 Glyoxylate and dicarboxylate metabolism 2 EFA12019.1;EFA12933.2 MetaCyc: PWY-6554 1D-myo-inositol hexakisphosphate biosynthesis V (from Ins(1,3,4)P3) 3 EFA02124.1;KYB25213.1;EFA10622.1 KEGG: 00860+1.3.3.3 Porphyrin and chlorophyll metabolism 1 EEZ98060.1 Reactome: R-HSA-983189 Kinesins 51 EFA05812.2;KYB26625.1;EFA07572.2;EFA04570.1;EEZ99331.1;EFA11494.1;KYB28909.1;EFA06187.1;EFA07279.1;EEZ99967.1;EFA04609.1;EFA01968.1;EFA10675.1;EEZ99348.1;EFA11416.2;EEZ99766.1;KYB26929.1;KYB27151.1;EEZ99070.2;KYB27386.1;EFA11147.1;KYB27927.1;EFA08595.1;EFA08843.1;EFA04613.2;EFA10972.1;EFA09822.2;EFA11148.1;KYB27385.1;KYB29658.1;EEZ97207.2;EFA00906.2;EEZ97891.1;EFA00856.2;EFA11512.2;EFA03966.2;KYB25512.1;EFA08129.2;EFA06663.1;KYB26178.1;EEZ97229.1;EFA11529.1;EFA11292.1;EFA02556.2;KYB29659.1;EFA11192.2;EFA02324.2;EFA04563.2;EFA06082.2;KYB27152.1;EFA04833.1 Reactome: R-HSA-936837 Ion transport by P-type ATPases 31 EEZ99807.2;EFA03901.1;KYB26921.1;KYB26922.1;EFA10430.1;EFA10815.1;EFA02157.2;EFA03902.2;KYB24975.1;EFA02978.1;KYB26515.1;EFA03903.2;EEZ97214.2;KYB27756.1;KYB27583.1;KYB27139.1;KYB28360.1;EFA02333.2;KYB26516.1;EFA08297.2;EFA11368.2;EFA04812.1;KYB27482.1;KYB27799.1;EFA03670.1;EFA06840.2;EFA05491.2;EEZ98712.1;EFA08800.1;EEZ97919.1;EFA12050.1 Reactome: R-HSA-2894862 Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants 27 KYB27078.1;EEZ98535.2;EFA01868.1;EFA07122.1;EFA02110.1;KYB29360.1;EFA07178.2;KYB26560.1;EEZ99094.1;EFA04470.1;EEZ99435.2;KYB27923.1;EFA10954.1;EFA05049.2;EFA02517.2;KYB29359.1;KYB29663.1;EFA02847.1;EFA04103.1;EEZ99767.1;KYB27259.1;KYB29308.1;EFA08457.1;EFA03528.1;EFA04105.2;KYB29228.1;EFA11522.2 MetaCyc: PWY-6587 Pyruvate fermentation to ethanol III 1 EEZ98950.2 KEGG: 00910+4.2.1.1 Nitrogen metabolism 5 EFA00432.1;EFA04508.1;EFA11790.2;EEZ98484.1;KYB29101.1 Reactome: R-HSA-2197563 NOTCH2 intracellular domain regulates transcription 1 EEZ99435.2 Reactome: R-HSA-9614399 Regulation of localization of FOXO transcription factors 1 EFA02105.1 Reactome: R-HSA-8983711 OAS antiviral response 1 EFA01192.1 Reactome: R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) 14 EFA11425.1;EFA10125.2;EFA07881.1;EFA11302.1;EFA07880.1;KYB29704.1;EFA00011.2;KYB26997.1;EFA02211.1;KYB28740.1;KYB29705.1;EEZ98657.1;EEZ98119.2;KYB29706.1 Reactome: R-HSA-5656169 Termination of translesion DNA synthesis 24 KYB28925.1;KYB26713.1;EFA03020.2;EFA02756.1;EFA03814.1;EFA09711.2;EFA06042.1;EFA07958.1;EFA11358.1;EFA12420.2;KYB29359.1;EFA12891.1;EFA09906.2;EFA06118.2;KYB29360.1;KYB25740.1;KYB28926.1;EFA04888.1;EFA08812.2;KYB27483.1;EFA08916.1;EFA06672.2;EFA02110.1;KYB25721.1 MetaCyc: PWY-7119 Ceramide and sphingolipid recycling and degradation (yeast) 3 EEZ97352.2;EEZ97351.1;EEZ97353.1 Reactome: R-HSA-428543 Inactivation of CDC42 and RAC1 1 EFA03253.1 MetaCyc: PWY-4202 Arsenate detoxification I (mammalian) 2 EFA01001.1;EFA03250.2 KEGG: 00340+2.1.1.22 Histidine metabolism 1 EFA06463.1 Reactome: R-HSA-8964038 LDL clearance 13 EFA11302.1;EFA11848.2;EFA11425.1;KYB29706.1;KYB26017.1;EFA11263.1;EFA02898.2;EFA09781.1;EFA02897.1;KYB29705.1;KYB26045.1;KYB26997.1;KYB29704.1 Reactome: R-HSA-210500 Glutamate Neurotransmitter Release Cycle 5 EEZ99137.2;KYB29537.1;KYB29538.1;KYB29539.1;EFA11037.2 KEGG: 00643+3.7.1.2 Styrene degradation 1 EFA06443.1 MetaCyc: PWY-6883 Pyruvate fermentation to butanol II (engineered) 3 EFA04382.1;EFA08151.1;EFA05073.1 KEGG: 00565+3.1.1.47 Ether lipid metabolism 1 EFA08568.1 Reactome: R-HSA-2243919 Crosslinking of collagen fibrils 4 EFA10680.1;EFA04092.2;KYB27188.1;KYB28517.1 Reactome: R-HSA-425986 Sodium/Proton exchangers 5 KYB29699.1;KYB28464.1;KYB28465.1;KYB29698.1;KYB28463.1 Reactome: R-HSA-1482922 Acyl chain remodelling of PI 8 EFA05083.2;EFA03430.2;KYB27220.1;KYB27219.1;EFA08691.1;EEZ98801.1;EEZ99784.2;KYB27221.1 Reactome: R-HSA-5610783 Degradation of GLI2 by the proteasome 42 EFA06741.1;EFA11079.1;EFA06519.1;EFA08664.1;EFA06200.1;KYB27556.1;EEZ97876.1;KYB26764.1;EFA03341.1;EFA02847.1;KYB27557.1;KYB29360.1;EEZ99493.1;EFA08911.2;EFA13218.1;EFA02345.1;EFA02110.1;EFA05833.1;KYB29272.1;EEZ99004.1;KYB24713.1;EFA05370.2;KYB25309.1;EFA04284.1;KYB26545.1;EFA07110.1;EFA05912.1;KYB29359.1;EFA05871.2;EFA07659.2;EFA09518.2;EFA08601.1;EFA03019.1;EFA05105.1;EEZ98185.1;EFA02331.1;EEZ97564.1;EFA07261.2;EFA09524.2;EFA08798.1;EFA05865.1;EFA04054.1 MetaCyc: PWY-7250 [2Fe-2S] iron-sulfur cluster biosynthesis 1 EFA04185.1 MetaCyc: PWY-7382 Lipoate biosynthesis and incorporation IV (yeast) 4 EFA05264.2;EFA02475.1;EEZ98826.2;EFA10961.1 KEGG: 00040+1.1.1.22 Pentose and glucuronate interconversions 1 KYB28935.1 Reactome: R-HSA-6806664 Metabolism of vitamin K 2 KYB26129.1;EFA08690.1 Reactome: R-HSA-8948216 Collagen chain trimerization 5 KYB27188.1;KYB25044.1;EFA04092.2;EFA04342.1;EFA00883.1 MetaCyc: PWY-6281 L-selenocysteine biosynthesis II (archaea and eukaryotes) 3 EFA06522.1;EFA06843.2;EEZ97530.1 Reactome: R-HSA-9646399 Aggrephagy 22 EEZ99331.1;EFA06187.1;KYB25072.1;EFA07465.1;EEZ97487.2;KYB26625.1;KYB25071.1;KYB29359.1;EFA04901.1;EEZ97891.1;EEZ99070.2;EEZ97229.1;EEZ99348.1;EFA02110.1;KYB26929.1;EFA06663.1;KYB26892.1;EFA03872.2;KYB29360.1;EFA09822.2;EFA04833.1;EFA11292.1 Reactome: R-HSA-3371571 HSF1-dependent transactivation 5 KYB28360.1;EFA08847.1;EEZ99807.2;EFA07964.1;EEZ97603.1 MetaCyc: PWY-6689 Trna splicing I 3 EFA08240.1;EEZ99511.2;KYB28730.1 MetaCyc: PWY-6638 Sulfolactate degradation III 3 EFA03109.1;EFA04122.1;KYB27212.1 MetaCyc: PWY-5481 Pyruvate fermentation to (S)-lactate 1 EFA01008.1 Reactome: R-HSA-4717374 Defective DPM1 causes DPM1-CDG (CDG-1e) 2 EFA04846.1;EFA06224.2 MetaCyc: PWY-6598 Sciadonate biosynthesis 21 EFA05977.1;EFA00084.1;KYB29211.1;EFA09483.1;EFA00083.2;EFA03752.1;KYB25453.1;EFA03551.1;EFA10643.2;EFA05143.1;KYB25229.1;KYB25454.1;EFA09796.1;EFA05473.2;KYB29213.1;EFA09795.1;KYB25455.1;EFA05474.1;EFA10642.1;EEZ97311.1;EFA10641.2 Reactome: R-HSA-5603041 IRAK4 deficiency (TLR2/4) 1 EFA01304.1 MetaCyc: PWY-6435 4-hydroxybenzoate biosynthesis III (plants) 3 EFA05073.1;EFA08151.1;EFA04382.1 Reactome: R-HSA-203927 MicroRNA (miRNA) biogenesis 17 EFA09197.2;EFA11550.2;EFA07031.1;KYB24989.1;EFA05348.1;KYB28470.1;EEZ99277.1;EFA10538.1;KYB26001.1;EFA06560.1;EFA03150.1;EFA04626.2;EFA05226.1;EFA11590.1;EFA05896.1;KYB25999.1;KYB26000.1 KEGG: 00190+7.1.1.8 Oxidative phosphorylation 2 EEZ97735.1;EFA01233.1 Reactome: R-HSA-4608870 Asymmetric localization of PCP proteins 40 EEZ97876.1;KYB27556.1;EFA03341.1;KYB26764.1;EFA06741.1;EFA06519.1;EFA11079.1;EFA08664.1;EFA06200.1;EFA02110.1;KYB27557.1;KYB29360.1;EEZ99493.1;EFA13218.1;EFA02345.1;EFA08911.2;KYB26545.1;EFA07110.1;EFA05912.1;KYB29359.1;KYB24713.1;EEZ99004.1;EFA05833.1;EFA05370.2;EFA04284.1;KYB25309.1;EFA07261.2;EEZ97564.1;EFA08798.1;EFA09524.2;EFA04054.1;EFA05865.1;EFA09518.2;EFA07659.2;EFA05871.2;EFA08601.1;EFA05105.1;EFA03019.1;EFA02331.1;EEZ98185.1 KEGG: 00260+4.3.1.19 Glycine, serine and threonine metabolism 1 EFA05892.1 Reactome: R-HSA-975163 IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation 4 EFA02110.1;KYB29359.1;EFA02851.1;KYB29360.1 MetaCyc: PWY-6398 Melatonin degradation I 1 EFA05733.1 KEGG: 00040+2.7.1.17 Pentose and glucuronate interconversions 1 EEZ98930.1 Reactome: R-HSA-418555 G alpha (s) signalling events 16 EFA01439.2;EFA10712.2;KYB25553.1;EFA03628.1;EFA03954.2;KYB27523.1;KYB28863.1;KYB25554.1;KYB25555.1;KYB25552.1;KYB25556.1;KYB27619.1;EFA04592.1;KYB25864.1;EFA03625.2;EFA03629.2 KEGG: 00532+2.4.2.26 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate 1 EFA12734.1 Reactome: R-HSA-5635838 Activation of SMO 3 EFA09161.1;KYB28973.1;EEZ97401.2 MetaCyc: PWY-5844 Menaquinol-9 biosynthesis 2 KYB27131.1;EFA05173.2 KEGG: 00071+5.1.2.3+4.2.1.17+1.1.1.35 Fatty acid degradation 3 EFA04382.1;EFA05073.1;EFA08151.1 MetaCyc: PWY-6802 Salidroside biosynthesis 1 EEZ98950.2 Reactome: R-HSA-2586552 Signaling by Leptin 2 KYB27132.1;EFA05273.2 Reactome: R-HSA-3214858 RMTs methylate histone arginines 24 EEZ99615.1;EFA13616.1;EFA13381.1;KYB25022.1;KYB29177.1;KYB29178.1;EFA10166.1;EEZ98442.1;EFA05036.1;EFA11773.1;EFA10996.1;EEZ99803.1;EFA11411.2;KYB25021.1;EFA00803.1;EFA01765.1;EEZ98189.2;EFA05453.1;EFA10612.1;EFA13640.1;KYB25018.1;EEZ97706.2;KYB24563.1;EFA09870.1 Reactome: R-HSA-390651 Dopamine receptors 1 EFA10743.2 MetaCyc: PWY-6607 Guanosine nucleotides degradation I 2 EFA09973.1;EFA01792.1 Reactome: R-HSA-8939246 RUNX1 regulates transcription of genes involved in differentiation of myeloid cells 2 EFA03630.2;KYB27618.1 Reactome: R-HSA-9616222 Transcriptional regulation of granulopoiesis 3 KYB27618.1;KYB24563.1;EFA03630.2 MetaCyc: PWY-7356 Thiamine salvage IV (yeast) 2 EEZ98443.2;KYB29167.1 Reactome: R-HSA-77305 Beta oxidation of palmitoyl-CoA to myristoyl-CoA 1 EFA04382.1 MetaCyc: PWY-7571 Ferrichrome A biosynthesis 1 EFA06304.1 Reactome: R-HSA-9609523 Insertion of tail-anchored proteins into the endoplasmic reticulum membrane 8 EFA09129.1;EFA01091.2;EFA01706.1;KYB27572.1;KYB27573.1;EFA03379.1;KYB26118.1;EFA01588.1 Reactome: R-HSA-159227 Transport of the SLBP independent Mature mRNA 21 EFA00581.2;EFA03584.1;EFA11447.2;EEZ97868.2;KYB29624.1;EEZ98143.1;EFA09537.1;EEZ98144.2;EFA11141.2;EFA00605.1;EFA05993.1;EEZ98695.2;KYB28630.1;EFA04928.2;KYB29364.1;EFA07823.1;KYB29271.1;EFA03859.1;KYB28401.1;EFA01249.2;EFA01782.2 Reactome: R-HSA-5610787 Hedgehog 'off' state 23 KYB27619.1;KYB25556.1;KYB29272.1;EFA03629.2;EFA03625.2;EFA02064.2;KYB26602.1;EFA06381.2;KYB25552.1;KYB25555.1;EFA11044.2;EFA01913.1;EEZ99469.1;EFA03628.1;EFA03954.2;KYB27523.1;KYB28863.1;EFA09161.1;KYB25554.1;EFA10712.2;EFA01439.2;KYB25553.1;KYB28779.1 MetaCyc: PWY-5855 Ubiquinol-7 biosynthesis (prokaryotic) 3 KYB26214.1;KYB26307.1;EFA04400.1 Reactome: R-HSA-2206291 MPS IIIC - Sanfilippo syndrome C 1 EFA00684.1 Reactome: R-HSA-171007 p38MAPK events 2 EFA11394.1;EFA11598.1 KEGG: 00020+4.2.1.3 Citrate cycle (TCA cycle) 2 EFA02996.1;EFA08121.1 Reactome: R-HSA-72163 mRNA Splicing - Major Pathway 89 EFA08170.1;EEZ98530.1;EFA08353.1;EFA09428.1;EEZ98143.1;EFA04447.2;EFA06003.1;EFA10607.2;EEZ97873.1;EFA08376.1;EFA13035.1;EFA05896.1;EFA03646.1;EEZ97870.1;KYB24867.1;EFA01964.1;EFA00843.1;EFA08116.2;EFA07821.1;EFA03021.1;EFA04291.1;EFA00436.1;KYB28470.1;EEZ98979.2;EFA12926.2;EFA07389.1;EFA03141.1;EFA12465.1;KYB29903.1;KYB26001.1;EFA00685.1;EFA04762.1;KYB29337.1;EFA03150.1;EFA03164.1;EFA12950.1;EFA12724.1;KYB26337.1;KYB26686.1;EEZ99482.1;EFA12938.2;EFA10322.1;EFA03421.1;EEZ97191.2;KYB29542.1;KYB26428.1;EFA12271.1;KYB26826.1;EFA09904.1;EFA07272.1;KYB29603.1;EFA00508.1;KYB28202.1;KYB26824.1;EFA00117.1;EEZ98144.2;EFA03226.1;KYB29336.1;EEZ97534.1;EFA06560.1;EFA07985.1;EFA10481.1;KYB28201.1;EFA11678.1;EFA02993.1;KYB27333.1;EEZ99018.1;EFA09312.2;KYB25540.1;EEZ97398.2;EFA10422.1;EEZ99094.1;EFA07031.1;EEZ97277.1;EFA11869.1;EEZ98096.1;EFA11531.2;EFA08132.1;EFA05604.1;EFA05269.2;EFA03550.1;EFA05457.1;KYB25152.1;EFA08544.1;EFA05226.1;EFA07541.2;KYB25334.1;EFA00260.1;EEZ97980.2 Reactome: R-HSA-2173789 TGF-beta receptor signaling activates SMADs 4 EFA07576.2;EFA04065.1;EFA05099.1;EEZ97734.1 KEGG: 00780+6.3.4.15 Biotin metabolism 1 EFA05264.2 Reactome: R-HSA-3645790 TGFBR2 Kinase Domain Mutants in Cancer 2 EFA07576.2;EEZ97734.1 KEGG: 00640+6.4.1.3 Propanoate metabolism 1 EFA03463.2 KEGG: 00051+4.1.2.13 Fructose and mannose metabolism 1 EFA04932.1 KEGG: 00040+5.1.3.1 Pentose and glucuronate interconversions 1 EEZ97576.1 Reactome: R-HSA-936964 Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon 5 EFA07517.1;KYB29360.1;EFA06854.1;KYB29359.1;EFA02110.1 KEGG: 00380+1.13.11.11 Tryptophan metabolism 1 EFA02356.1 KEGG: 00230+3.6.1.9 Purine metabolism 2 EFA04414.1;EFA03919.1 Reactome: R-HSA-1834941 STING mediated induction of host immune responses 1 EFA08516.2 Reactome: R-HSA-389948 PD-1 signaling 1 EFA12064.1 Reactome: R-HSA-8950505 Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation 6 EEZ98080.1;EFA09191.1;EFA07386.2;EEZ98476.1;EFA03253.1;EEZ98187.1 KEGG: 00071+1.1.1.1 Fatty acid degradation 1 EEZ98950.2 KEGG: 00260+2.6.1.52 Glycine, serine and threonine metabolism 1 EEZ98123.1 Reactome: R-HSA-3371453 Regulation of HSF1-mediated heat shock response 48 EEZ98080.1;EFA00824.1;KYB28630.1;EFA02143.1;EEZ97171.1;EFA04928.2;EFA09711.2;EFA08256.1;EFA07823.1;KYB29271.1;EFA09052.2;EFA12235.1;EFA01249.2;KYB28401.1;EFA07510.1;EFA03584.1;EFA12891.1;EFA00581.2;EFA07459.1;EEZ98819.2;EEZ97868.2;KYB26038.1;EFA11141.2;EFA09537.1;EFA03316.2;KYB29624.1;EFA06541.1;KYB25034.1;EEZ97821.1;EFA10708.1;EFA09055.1;EFA00605.1;EEZ98695.2;EFA07817.1;EFA08852.1;EFA02300.1;KYB29364.1;EFA11787.2;KYB25791.1;EFA01782.2;EFA03859.1;EFA09906.2;KYB28730.1;KYB27483.1;EFA11447.2;EFA02305.1;EFA07173.1;EFA05993.1 Reactome: R-HSA-8869496 TFAP2A acts as a transcriptional repressor during retinoic acid induced cell differentiation 2 EFA03596.1;EFA09757.1 Reactome: R-HSA-881907 Gastrin-CREB signalling pathway via PKC and MAPK 2 EFA02835.2;EFA10708.1 Reactome: R-HSA-392851 Prostacyclin signalling through prostacyclin receptor 1 KYB25864.1 KEGG: 00680+3.1.2.12 Methane metabolism 1 EFA04060.1 Reactome: R-HSA-140837 Intrinsic Pathway of Fibrin Clot Formation 3 EFA07880.1;EFA13033.1;EFA07881.1 KEGG: 00531+3.2.1.23 Glycosaminoglycan degradation 9 EFA06933.2;EFA07843.2;EEZ97806.1;EFA07842.1;EFA04110.1;EEZ99315.1;KYB26528.1;EEZ99316.1;EFA07841.1 KEGG: 00623+1.1.1.35 Toluene degradation 3 EFA04382.1;EFA05073.1;EFA08151.1 MetaCyc: PWY-8053 Anandamide biosynthesis II 33 EFA02132.1;EEZ97656.1;KYB26689.1;KYB29358.1;KYB27219.1;EFA11812.1;EFA09975.1;KYB27110.1;EFA12575.1;EFA07860.2;EFA09487.1;EFA07054.2;EEZ98801.1;EFA07968.1;EFA13468.1;EFA08691.1;EFA09107.1;EFA12278.1;EFA05083.2;EFA03430.2;KYB27220.1;KYB27221.1;EFA12460.1;KYB26367.1;EFA06119.2;KYB27111.1;EFA04525.1;EEZ99784.2;KXZ75683.1;EEZ97257.1;EFA12309.1;EFA13680.1;EFA12193.1 MetaCyc: PWY-6611 Adenine and adenosine salvage V 4 EFA00425.1;EFA00339.1;EFA01001.1;EFA03250.2 MetaCyc: PWY-7803 Trna splicing II 3 KYB28730.1;EEZ99511.2;EFA08240.1 KEGG: 00531+3.2.1.50 Glycosaminoglycan degradation 2 KYB27868.1;EFA02249.1 KEGG: 04070+3.1.3.78 Phosphatidylinositol signaling system 1 EFA01248.1 MetaCyc: PWY-6857 Retinol biosynthesis 2 EFA10312.1;KYB25598.1 Reactome: R-HSA-69052 Switching of origins to a post-replicative state 8 EFA06648.2;EFA03620.1;EEZ97575.1;KYB26668.1;EEZ97375.1;EEZ97925.1;EFA13575.1;EFA12381.1 Reactome: R-HSA-912694 Regulation of IFNA signaling 1 EFA12064.1 Reactome: R-HSA-5218920 VEGFR2 mediated vascular permeability 9 EFA10417.1;EEZ97169.2;EFA10738.2;KYB24949.1;EFA00152.1;EFA10737.2;EFA07964.1;EFA02105.1;EEZ99088.1 KEGG: 00250+1.2.1.88 Alanine, aspartate and glutamate metabolism 1 EFA05239.1 Reactome: R-HSA-6811558 PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling 8 KYB26383.1;EFA05992.2;KYB29656.1;EFA02851.1;KYB26642.1;EFA01355.2;EFA10708.1;EFA01304.1 MetaCyc: PWY-5690 TCA cycle II (plants and fungi) 12 EFA02829.1;EFA10709.2;EFA07160.1;EFA05014.1;EFA03144.1;EFA03750.1;EFA02482.1;EFA11202.1;EFA04972.1;EFA09226.1;EFA04683.1;EFA11129.1 MetaCyc: PWY-7268 NAD/NADP-NADH/NADPH cytosolic interconversion (yeast) 7 EFA10595.2;EFA08909.2;EFA03565.2;KYB26619.1;KYB27681.1;EFA09539.1;EFA04299.1 Reactome: R-HSA-2214320 Anchoring fibril formation 3 KYB28517.1;EFA04092.2;KYB27188.1 KEGG: 00620+4.4.1.5 Pyruvate metabolism 1 EFA05578.1 MetaCyc: PWY-2161 Folate polyglutamylation 4 EFA07237.1;EFA07236.1;EEZ98122.1;EFA09131.1 Reactome: R-HSA-77348 Beta oxidation of octanoyl-CoA to hexanoyl-CoA 1 EFA04382.1 Reactome: R-HSA-200425 Carnitine metabolism 2 EFA05436.2;EFA10830.1 Reactome: R-HSA-69273 Cyclin A/B1/B2 associated events during G2/M transition 6 EFA10997.1;EFA07055.2;EEZ98354.1;EFA06469.1;EFA12824.1;EFA09995.1 Reactome: R-HSA-9613354 Lipophagy 1 EFA02004.1 Reactome: R-HSA-5173214 O-glycosylation of TSR domain-containing proteins 24 EFA06592.2;KYB26314.1;EFA07053.2;EFA07189.2;KYB26518.1;KYB26691.1;KYB26318.1;EFA05320.1;EFA05047.2;EEZ98513.2;EFA01753.1;KYB26305.1;EFA01634.1;KYB29003.1;KYB26519.1;KYB26517.1;EFA01633.2;KYB29418.1;EEZ98133.1;EFA05321.1;KYB26317.1;KYB26304.1;KYB26430.1;KYB29417.1 Reactome: R-HSA-2129379 Molecules associated with elastic fibres 4 EEZ98051.1;KYB28697.1;KYB28696.1;EFA10689.2 Reactome: R-HSA-2467813 Separation of Sister Chromatids 98 EFA05105.1;EFA06492.1;EEZ98185.1;EFA11447.2;EFA02331.1;EFA09518.2;EFA07677.2;EFA09822.2;EFA08601.1;EFA01854.1;EEZ99348.1;KYB26929.1;EEZ99272.2;EEZ99210.2;EEZ97564.1;EFA04284.1;KYB26468.1;KYB24713.1;EEZ99004.1;EFA07500.2;EFA06856.2;EEZ97230.1;KYB25071.1;KYB26625.1;EFA07110.1;KYB27187.1;EFA07755.2;KYB29359.1;EFA01569.1;EFA11292.1;EEZ99493.1;KYB25237.1;EFA13218.1;EFA08911.2;EEZ98849.2;KYB26892.1;EFA04833.1;EFA04231.1;EFA06663.1;EFA02110.1;EEZ97989.1;KYB25236.1;EFA00171.1;EEZ97229.1;KYB29624.1;EFA06741.1;EFA11079.1;EFA03341.1;EFA00073.1;EEZ97189.1;EEZ97876.1;KYB27556.1;KYB25235.1;EFA03019.1;EEZ97419.2;EFA05871.2;KYB26383.1;EFA07659.2;EFA08798.1;EFA09524.2;KYB25616.1;EFA05865.1;KYB27271.1;EFA04054.1;EEZ99070.2;EFA07261.2;EFA05370.2;KYB25309.1;EFA13202.2;EFA05833.1;EFA05912.1;EEZ99331.1;KYB25814.1;EFA06187.1;KYB25072.1;KYB26545.1;KYB27439.1;EFA02345.1;KYB27557.1;EFA05992.2;KYB29360.1;EFA09995.1;KYB25744.1;EFA09537.1;KYB26642.1;EFA04692.2;EFA08664.1;EFA07920.2;EEZ97891.1;EFA06200.1;EEZ98737.1;EFA06519.1;EFA04506.2;EEZ97487.2;KYB26764.1;KYB27370.1;EFA07823.1;EFA09410.1 KEGG: 00970+6.3.5.7 Aminoacyl-tRNA biosynthesis 7 EFA07993.1;KYB29141.1;KYB29142.1;EFA03686.1;EFA09017.1;EEZ98237.1;EEZ98236.2 Reactome: R-HSA-9635644 Inhibition of membrane repair 1 EFA09116.1 Reactome: R-HSA-167172 Transcription of the HIV genome 30 KYB28470.1;EFA00018.1;EFA06469.1;EEZ97886.2;EEZ99738.1;EFA03759.1;EFA05897.1;EFA07031.1;KYB29038.1;EEZ97398.2;EFA07302.1;EFA02310.1;EFA07055.2;EFA05226.1;EFA02321.1;KYB29037.1;EFA05523.2;KYB25378.1;KYB25152.1;EFA03550.1;EFA03150.1;KYB26001.1;EFA06560.1;EFA11878.1;EFA06253.1;EFA03052.1;EFA00328.1;EFA00911.1;EFA05896.1;EFA03093.1 KEGG: 00240+2.4.2.1 Pyrimidine metabolism 2 EFA01001.1;EFA03250.2 Reactome: R-HSA-975871 MyD88 cascade initiated on plasma membrane 3 EFA01304.1;EFA07356.1;EFA02851.1 Reactome: R-HSA-111464 SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes 5 EFA01361.1;KYB27348.1;EFA08214.1;KYB27349.1;EEZ98372.1 KEGG: 00480+1.1.1.49 Glutathione metabolism 2 KYB27681.1;EFA03565.2 Reactome: R-HSA-1227986 Signaling by ERBB2 2 EFA01355.2;EFA03198.1 KEGG: 00330+2.6.1.1 Arginine and proline metabolism 3 EFA03109.1;EFA04122.1;KYB27212.1 MetaCyc: PWY-5067 Glycogen biosynthesis II (from UDP-D-Glucose) 9 KYB29169.1;EEZ98206.2;EEZ98451.1;EEZ98452.1;EEZ98454.1;EFA05468.1;EEZ98450.1;EFA11030.1;KYB29170.1 KEGG: 00511+3.2.1.96 Other glycan degradation 1 EFA09314.2 MetaCyc: PWY-7856 Heme a biosynthesis 1 KYB25345.1 KEGG: 00052+5.1.3.3 Galactose metabolism 3 EFA01124.1;KYB29855.1;KYB29856.1 Reactome: R-HSA-176409 APC/C:Cdc20 mediated degradation of mitotic proteins 12 EEZ98737.1;EEZ98849.2;KYB25814.1;EFA01569.1;EEZ97989.1;EEZ99272.2;KYB27271.1;EEZ97189.1;KYB27187.1;EFA01854.1;EFA04231.1;EFA00073.1 MetaCyc: PWY-7887 Protein SAMPylation and SAMP-mediated thiolation 2 EFA07642.2;EFA06321.2 KEGG: 00230+6.3.5.3 Purine metabolism 2 EFA02192.2;EFA11870.2 Reactome: R-HSA-176407 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase 12 EEZ98849.2;EEZ98737.1;EEZ97189.1;EEZ99272.2;KYB27271.1;EFA04231.1;EFA00073.1;EFA01854.1;KYB27187.1;KYB25814.1;EEZ97989.1;EFA01569.1 KEGG: 00480+2.5.1.18 Glutathione metabolism 1 EFA08560.1 Reactome: R-HSA-6785631 ERBB2 Regulates Cell Motility 3 EFA01355.2;KYB28004.1;EFA10845.1 KEGG: 00564+1.1.1.94 Glycerophospholipid metabolism 3 KYB29133.1;EEZ98249.2;KYB29132.1 KEGG: 00770+3.6.1.9 Pantothenate and CoA biosynthesis 2 EFA03919.1;EFA04414.1 KEGG: 00770+6.3.2.5 Pantothenate and CoA biosynthesis 1 EEZ97196.1 Reactome: R-HSA-8941284 RUNX2 regulates chondrocyte maturation 2 KYB27618.1;EFA03630.2 Reactome: R-HSA-5658442 Regulation of RAS by GAPs 42 EFA05105.1;EFA03019.1;EFA02331.1;EEZ98185.1;EFA09518.2;EFA07659.2;EFA05871.2;EFA08601.1;EFA08798.1;EFA09524.2;EFA04054.1;EFA05865.1;EFA07261.2;EEZ97564.1;EFA05370.2;KYB25309.1;EFA04284.1;KYB24713.1;EFA05833.1;EEZ99004.1;EFA07110.1;EEZ97639.1;KYB29359.1;EFA05912.1;KYB26545.1;EEZ99493.1;EFA02345.1;EFA13218.1;EFA08911.2;KYB27557.1;KYB29360.1;EFA02110.1;EFA01244.2;EFA08664.1;EFA06200.1;EFA06741.1;EFA06519.1;EFA11079.1;EFA03341.1;KYB26764.1;KYB27556.1;EEZ97876.1 Reactome: R-HSA-1369062 ABC transporters in lipid homeostasis 18 EFA09999.1;EFA09850.1;EFA08097.2;KYB29666.1;EFA09849.1;EFA09595.1;EFA01515.1;EFA01864.1;EFA01863.2;KYB25373.1;EFA02729.1;KYB25372.1;EFA05071.1;KYB28165.1;EFA01493.1;EFA02575.1;EFA00035.1;EFA01865.1 KEGG: 00310+1.2.4.2 Lysine degradation 4 EFA10391.1;KYB27599.1;EFA04760.2;EFA05916.2 KEGG: 00020+1.1.1.42 Citrate cycle (TCA cycle) 3 EFA09539.1;EFA04299.1;EFA10595.2 Reactome: R-HSA-69166 Removal of the Flap Intermediate 16 EFA06042.1;EFA04623.2;EFA09711.2;EFA07958.1;EFA07996.1;EFA06383.1;KYB28925.1;EFA09576.1;KYB25721.1;EEZ99558.2;EFA07750.2;KYB27483.1;KYB28926.1;EFA10435.1;EFA12891.1;EFA09906.2 Reactome: R-HSA-8866654 E3 ubiquitin ligases ubiquitinate target proteins 17 EFA03559.1;EEZ99586.2;KYB29064.1;EEZ99162.2;EFA02110.1;EFA00146.1;EFA10352.2;KYB29360.1;EFA06668.1;KYB29359.1;KYB27725.1;EFA06042.1;EFA04853.2;EFA07465.1;EEZ97432.2;KYB29057.1;KYB25563.1 MetaCyc: PWY-6123 Inosine-5'-phosphate biosynthesis I 3 EFA08776.1;EEZ98830.1;EEZ97680.1 Reactome: R-HSA-9008059 Interleukin-37 signaling 1 EFA12064.1 Reactome: R-HSA-1679131 Trafficking and processing of endosomal TLR 6 EFA09154.2;EFA01286.1;EFA01288.1;EFA01287.1;EFA01289.1;EFA09153.1 KEGG: 00350+1.1.1.1 Tyrosine metabolism 1 EEZ98950.2 MetaCyc: PWY-2201 Folate transformations I 4 EFA07237.1;EFA09131.1;EFA07236.1;EFA07809.2 KEGG: 00627+1.14.14.1 Aminobenzoate degradation 1 EFA05733.1 KEGG: 00280+6.4.1.3 Valine, leucine and isoleucine degradation 1 EFA03463.2 Reactome: R-HSA-1482883 Acyl chain remodeling of DAG and TAG 1 EFA04221.1 Reactome: R-HSA-392451 G beta:gamma signalling through PI3Kgamma 3 EFA02105.1;KYB25864.1;EFA00152.1 KEGG: 00860+4.2.1.75 Porphyrin and chlorophyll metabolism 1 EFA10147.1 KEGG: 00240+3.6.1.23 Pyrimidine metabolism 1 EFA05862.1 Reactome: R-HSA-3000157 Laminin interactions 13 KYB27641.1;KYB27445.1;EFA04092.2;KYB28643.1;EFA01213.2;KYB27637.1;KYB27188.1;KYB27643.1;KYB28537.1;KYB27644.1;KYB27642.1;EFA01328.2;EFA04469.2 Reactome: R-HSA-8875555 MET activates RAP1 and RAC1 1 EFA11162.1 Reactome: R-HSA-73772 RNA Polymerase I Promoter Escape 17 EFA03150.1;KYB26001.1;KYB25378.1;EFA05896.1;EFA00328.1;EFA07031.1;KYB24563.1;EFA07284.1;EFA00018.1;KYB28470.1;EFA06469.1;EFA07302.1;EFA08638.2;EEZ99110.1;EFA07055.2;KYB26622.1;EFA02310.1 Reactome: R-HSA-211163 AKT-mediated inactivation of FOXO1A 1 EFA02105.1 MetaCyc: PWY-2301 Myo-inositol biosynthesis 3 KYB25020.1;EFA09280.1;EFA12936.1 Reactome: R-HSA-1660517 Synthesis of PIPs at the late endosome membrane 5 KYB26276.1;KYB26275.1;EFA00380.1;EFA06197.2;EEZ98191.1 MetaCyc: PWY-7254 TCA cycle VII (acetate-producers) 8 EFA10709.2;EFA03144.1;EFA09226.1;EFA04683.1;EFA02829.1;EFA10595.2;EFA09539.1;EFA04299.1 KEGG: 00270+1.1.1.27 Cysteine and methionine metabolism 1 EFA01008.1 Reactome: R-HSA-451308 Activation of Ca-permeable Kainate Receptor 1 KYB29108.1 KEGG: 00230+6.3.4.4 Purine metabolism 1 KYB26701.1 KEGG: 00970+6.1.1.3 Aminoacyl-tRNA biosynthesis 4 KYB25398.1;EFA07887.2;EFA08239.1;KYB26192.1 Reactome: R-HSA-1362300 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 3 EFA02434.1;EFA01741.1;EFA08856.2 Reactome: R-HSA-8964041 LDL remodeling 6 EFA11302.1;KYB29706.1;KYB29705.1;KYB29704.1;KYB26997.1;EFA11425.1 Reactome: R-HSA-964975 Vitamins B6 activation to pyridoxal phosphate 3 EFA00408.1;EFA10196.1;KYB25431.1 Reactome: R-HSA-1855204 Synthesis of IP3 and IP4 in the cytosol 10 EFA11114.1;KYB28995.1;KYB27925.1;KXZ75917.1;EFA02124.1;EFA09929.2;KYB27786.1;KYB28994.1;KXZ75916.1;EFA12319.2 KEGG: 00380+2.3.1.61 Tryptophan metabolism 1 EFA07230.2 Reactome: R-HSA-3769402 Deactivation of the beta-catenin transactivating complex 15 KYB28976.1;EFA02110.1;KYB29359.1;KYB28556.1;KYB28558.1;EFA11241.1;EEZ99317.2;EFA13272.2;EFA09995.1;KYB29360.1;KYB28557.1;EFA02211.1;KYB28559.1;KYB29349.1;KYB28977.1 KEGG: 00230+3.5.2.17 Purine metabolism 2 EEZ99723.1;KYB28295.1 MetaCyc: PWY-5080 Very long chain fatty acid biosynthesis I 21 EFA05977.1;EFA00084.1;KYB29211.1;EFA00083.2;EFA03752.1;EFA09483.1;EFA03551.1;KYB25453.1;EFA10643.2;EFA05143.1;EFA09796.1;KYB25454.1;EFA05473.2;KYB25229.1;EFA05474.1;EFA09795.1;KYB25455.1;KYB29213.1;EFA10641.2;EEZ97311.1;EFA10642.1 KEGG: 00061+6.4.1.2 Fatty acid biosynthesis 1 EFA05436.2 KEGG: 00332+1.2.1.41+2.7.2.11 Carbapenem biosynthesis 1 EEZ98981.2 MetaCyc: PWY-8106 Queuosine biosynthesis III (queuosine salvage) 2 EFA00359.1;EFA02997.1 Reactome: R-HSA-2028269 Signaling by Hippo 3 EFA11019.1;KYB25057.1;EEZ97473.2 MetaCyc: PWY-7838 Globo-series glycosphingolipids biosynthesis 1 EFA12048.1 KEGG: 05163+2.7.1.153 Human cytomegalovirus infection 1 EFA09848.2 MetaCyc: PWY-7800 Ac/N-end rule pathway 3 KYB26774.1;EFA13129.1;EEZ97675.1 MetaCyc: PWY-6609 Adenine and adenosine salvage III 4 EFA03250.2;EFA01001.1;EFA00339.1;EFA00425.1 Reactome: R-HSA-5661270 Formation of xylulose-5-phosphate 1 EEZ98930.1 Reactome: R-HSA-425366 Transport of bile salts and organic acids, metal ions and amine compounds 18 KYB28735.1;EEZ98759.2;EFA12126.2;KXZ75648.1;KYB28734.1;KYB28736.1;KYB28357.1;KYB28985.1;KYB28984.1;KYB28737.1;EFA10286.1;KYB29042.1;EFA01113.1;KYB28529.1;EFA01165.1;EFA01115.1;KYB28528.1;KXZ75649.1 Reactome: R-HSA-8941856 RUNX3 regulates NOTCH signaling 4 EEZ99435.2;EFA02517.2;EFA04470.1;EEZ99094.1 MetaCyc: PWY-6992 1,5-anhydrofructose degradation 3 EFA01794.1;EFA05733.1;EFA07687.2 Reactome: R-HSA-69017 CDK-mediated phosphorylation and removal of Cdc6 53 EFA05912.1;KYB29359.1;KYB27187.1;EFA07110.1;KYB26545.1;KYB25814.1;EFA01569.1;EFA03095.1;EFA04284.1;KYB25309.1;EFA05370.2;EFA05833.1;EEZ99004.1;KYB24713.1;EEZ99272.2;EFA05865.1;EFA04054.1;KYB27271.1;EFA01854.1;EFA09524.2;EFA08798.1;EEZ97564.1;EFA07261.2;EEZ98185.1;EFA02331.1;EFA03019.1;EFA05105.1;EFA08601.1;EFA07659.2;EFA05871.2;EFA09518.2;EEZ97189.1;KYB26764.1;EFA00073.1;EFA03341.1;EEZ97876.1;KYB27556.1;EFA06200.1;EFA08664.1;EFA11079.1;EFA06519.1;EFA06741.1;EEZ98737.1;EFA02110.1;EFA04231.1;EEZ97989.1;EFA08911.2;EFA13218.1;EFA02345.1;EEZ99493.1;KYB29360.1;KYB27557.1;EEZ98849.2 MetaCyc: PWY-6823 Molybdenum cofactor biosynthesis 3 EEZ98181.1;EFA06321.2;EFA02449.2 Reactome: R-HSA-3359463 Defective CUBN causes hereditary megaloblastic anemia 1 1 EFA05060.1 MetaCyc: PWY-5491 Diethylphosphate degradation 4 EFA01926.1;KYB29475.1;KYB25767.1;KYB26031.1 Reactome: R-HSA-77075 RNA Pol II CTD phosphorylation and interaction with CE 20 EFA00328.1;EFA05896.1;EFA05446.1;KYB25152.1;EFA05226.1;KYB25378.1;KYB26001.1;EFA06560.1;EFA03004.2;EFA03550.1;EFA03150.1;EFA02310.1;EFA07055.2;EFA07302.1;EFA06469.1;EFA00018.1;KYB28470.1;EEZ97398.2;EFA03427.1;EFA07031.1 KEGG: 00270+6.3.2.3 Cysteine and methionine metabolism 2 EFA06494.1;EFA06495.2 MetaCyc: PWY-7158 L-phenylalanine degradation V 2 EFA07130.1;EEZ99507.1 KEGG: 00900+3.4.24.84 Terpenoid backbone biosynthesis 2 EEZ97450.1;EEZ98057.1 MetaCyc: PWY-6620 Guanine and guanosine salvage 2 EFA01001.1;EFA03250.2 Reactome: R-HSA-8951936 RUNX3 regulates p14-ARF 2 EFA03630.2;KYB27618.1 MetaCyc: PWY-7269 NAD/NADP-NADH/NADPH mitochondrial interconversion (yeast) 2 EFA08909.2;KYB26619.1 Reactome: R-HSA-68952 DNA replication initiation 7 EFA07750.2;KYB26713.1;EFA06672.2;EFA04623.2;EFA10435.1;EFA09576.1;EFA07996.1 Reactome: R-HSA-6782861 Synthesis of wybutosine at G37 of tRNA(Phe) 1 EFA12884.2 MetaCyc: PWY-7409 Phospholipid remodeling (phosphatidylethanolamine, yeast) 23 EFA12460.1;KYB27221.1;KYB26689.1;KYB29358.1;KYB27219.1;EFA11812.1;EFA09487.1;EEZ99784.2;EFA12575.1;KXZ75683.1;EFA07860.2;EFA13680.1;EEZ98801.1;EFA12309.1;EFA08691.1;EFA07968.1;EFA13468.1;EFA03430.2;KYB27220.1;EFA12193.1;EFA09107.1;EFA12278.1;EFA05083.2 KEGG: 04070+2.7.11.13 Phosphatidylinositol signaling system 5 KYB26446.1;KYB28728.1;EFA07407.1;KYB26120.1;EFA07406.1 KEGG: 00330+1.14.13.39 Arginine and proline metabolism 2 EFA10400.2;KYB25321.1 KEGG: 00982+1.1.1.1 Drug metabolism - cytochrome P450 1 EEZ98950.2 Reactome: R-HSA-5626467 RHO GTPases activate IQGAPs 17 EEZ97891.1;EFA06187.1;EEZ99331.1;KYB25235.1;KYB26625.1;EFA09822.2;EFA04833.1;EFA02211.1;EFA11292.1;KYB25237.1;EEZ97229.1;KYB25236.1;EEZ99070.2;KYB26929.1;EFA06663.1;EFA03253.1;EEZ99348.1 KEGG: 00250+6.3.5.4 Alanine, aspartate and glutamate metabolism 1 KYB27475.1 KEGG: 00562+3.1.4.11 Inositol phosphate metabolism 7 KYB28995.1;KYB27925.1;KYB27786.1;KYB28994.1;KXZ75917.1;EFA12319.2;KXZ75916.1 Reactome: R-HSA-2160456 Phenylketonuria 1 EEZ99507.1 KEGG: 00563+2.4.1.198 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis 5 KYB26258.1;EFA04308.1;EFA04752.1;EFA00579.1;KYB26259.1 Reactome: R-HSA-8866904 Negative regulation of activity of TFAP2 (AP-2) family transcription factors 1 EFA07527.2 Reactome: R-HSA-419771 Opsins 1 EFA03667.1 KEGG: 00940+1.11.1.7 Phenylpropanoid biosynthesis 1 EFA01243.1 Reactome: R-HSA-110331 Cleavage of the damaged purine 4 EFA00785.1;EFA06198.1;EEZ98702.1;KYB24563.1 MetaCyc: PWY-6557 Glycosaminoglycan-protein linkage region biosynthesis 1 EFA12734.1 Reactome: R-HSA-4085001 Sialic acid metabolism 4 KYB28573.1;EFA04036.1;EFA09133.1;EEZ97826.1 KEGG: 05165+2.7.11.1 Human papillomavirus infection 55 EFA07902.1;EFA04100.2;EFA02123.1;EFA11184.1;EFA11019.1;EEZ99162.2;KYB28836.1;KYB28439.1;KYB29263.1;KYB28438.1;KYB28374.1;EFA08613.1;KYB25762.1;KYB27402.1;EFA13584.2;EEZ98563.1;EFA00805.1;EFA00476.1;EFA11391.2;EFA00691.2;EFA06330.1;EFA05002.2;KYB27919.1;KYB26173.1;EFA01876.2;KYB28377.1;KYB28375.1;KYB27979.1;KYB28376.1;EFA08636.2;EFA07752.1;EFA11394.1;EFA00769.1;EFA10912.2;EFA00152.1;EFA10048.1;EFA08276.1;KYB29873.1;EFA11787.2;EFA03058.1;EFA02105.1;EFA07964.1;EEZ98574.2;EFA02342.2;EEZ97987.1;EFA04406.2;EFA10720.1;KYB25791.1;KYB27978.1;EEZ99828.2;EFA07410.1;KYB28837.1;EFA05720.1;KYB27138.1;KYB28437.1 MetaCyc: PWY-7902 Glucosylglycerol biosynthesis 3 KYB29132.1;EEZ98249.2;KYB29133.1 Reactome: R-HSA-5578775 Ion homeostasis 10 KYB28433.1;KYB29733.1;EEZ99807.2;EFA10430.1;KYB28360.1;EFA06448.1;EEZ99829.2;EFA11212.2;EFA12050.1;KYB29732.1 Reactome: R-HSA-8874081 MET activates PTK2 signaling 13 KYB27643.1;KYB27642.1;KYB27644.1;EFA01328.2;KYB28537.1;KYB25044.1;EFA04469.2;EFA04342.1;KYB27641.1;KYB27445.1;KYB28643.1;KYB27637.1;EFA01213.2 KEGG: 00230+3.6.1.15 Purine metabolism 1 KYB29374.1 Reactome: R-HSA-418594 G alpha (i) signalling events 35 KYB25555.1;EEZ97715.2;EFA11094.1;KYB25968.1;EFA03625.2;KYB25864.1;EEZ98580.1;KYB25253.1;EEZ97729.2;KYB27619.1;KYB25556.1;KYB25970.1;EFA10303.2;EFA02808.2;EFA00406.2;EFA01439.2;EFA07881.1;KYB25554.1;EFA04253.1;EFA03954.2;KYB25552.1;EFA07880.1;KYB25254.1;EFA03629.2;EFA10792.1;KYB25969.1;KYB25553.1;EFA10712.2;EFA06873.1;EFA10835.1;KYB28863.1;KYB27523.1;KYB29661.1;EFA09228.1;EFA03628.1 KEGG: 00450+6.1.1.10 Selenocompound metabolism 2 KYB25592.1;EFA06771.1 Reactome: R-HSA-112308 Presynaptic depolarization and calcium channel opening 3 KYB27418.1;KYB27419.1;EFA03876.1 KEGG: 00230+4.1.1.21 Purine metabolism 1 EEZ97680.1 MetaCyc: PWY-6372 1D-myo-inositol hexakisphosphate biosynthesis IV (Dictyostelium) 3 KYB25213.1;EFA10622.1;EFA09280.1 KEGG: 00970+6.1.1.4 Aminoacyl-tRNA biosynthesis 2 EFA00333.1;EFA02651.1 Reactome: R-HSA-381771 Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) 4 EFA07146.1;EFA02397.1;EEZ97812.1;EFA03199.1 Reactome: R-HSA-2219530 Constitutive Signaling by Aberrant PI3K in Cancer 2 KYB29656.1;EFA01355.2 Reactome: R-HSA-2122947 NOTCH1 Intracellular Domain Regulates Transcription 19 EFA08457.1;KYB28977.1;EEZ99767.1;EFA11522.2;EFA04105.2;KYB27923.1;EEZ99435.2;EFA02847.1;KYB29663.1;KYB28976.1;KYB29359.1;EFA02517.2;KYB29360.1;KYB29349.1;EFA04470.1;EEZ99094.1;EEZ99317.2;EFA02110.1;EFA01868.1 Reactome: R-HSA-375276 Peptide ligand-binding receptors 10 EFA02911.1;EFA02808.2;EEZ97715.2;EFA07881.1;EFA09272.1;EFA07880.1;KYB25711.1;EFA10792.1;EFA02835.2;EEZ97729.2 KEGG: 00250+2.6.1.19 Alanine, aspartate and glutamate metabolism 2 KYB25522.1;KYB25521.1 Reactome: R-HSA-8934593 Regulation of RUNX1 Expression and Activity 9 KYB26000.1;KYB25999.1;KYB25778.1;EFA11590.1;EFA08972.2;KYB27618.1;EFA04626.2;EFA03630.2;EFA09197.2 Reactome: R-HSA-5674499 Negative feedback regulation of MAPK pathway 1 EFA10708.1 Reactome: R-HSA-159231 Transport of Mature mRNA Derived from an Intronless Transcript 25 EFA07823.1;KYB29271.1;KYB29364.1;KYB26686.1;EFA01782.2;EFA01249.2;KYB28401.1;EFA02993.1;EFA03859.1;KYB28630.1;EEZ98695.2;EFA04928.2;EFA09537.1;EEZ98143.1;EEZ98144.2;EFA11141.2;KYB29624.1;EFA03141.1;EFA05993.1;EFA00605.1;EFA07272.1;EFA03584.1;EFA00581.2;EFA11447.2;EEZ97868.2 KEGG: 00400+2.6.1.1 Phenylalanine, tyrosine and tryptophan biosynthesis 3 EFA04122.1;KYB27212.1;EFA03109.1 MetaCyc: PWY-5486 Pyruvate fermentation to ethanol II 1 EEZ98950.2 Reactome: R-HSA-3785653 Myoclonic epilepsy of Lafora 3 KYB29360.1;KYB29359.1;EFA02110.1 MetaCyc: PWY-5789 3-hydroxypropanoate/4-hydroxybutanate cycle 12 EFA08151.1;EFA07129.2;EFA11790.2;EFA03463.2;EFA03586.1;EFA04508.1;EFA04382.1;KYB29101.1;EFA05073.1;EFA05436.2;EEZ98484.1;EFA00432.1 Reactome: R-HSA-181429 Serotonin Neurotransmitter Release Cycle 7 KYB29537.1;EEZ99137.2;EFA12118.1;KYB29538.1;KXZ75661.1;KYB29539.1;KXZ75660.1 Reactome: R-HSA-111458 Formation of apoptosome 6 EFA01361.1;KYB27349.1;EEZ98372.1;EFA07698.1;KYB27348.1;EFA08214.1 MetaCyc: PWY-6901 Superpathway of glucose and xylose degradation 14 EFA08842.1;EFA01008.1;EFA05374.1;EFA08517.1;KYB24935.1;EFA07763.1;EEZ99016.2;KYB25941.1;EFA09610.1;EEZ97193.2;EFA09609.1;EFA10506.1;EFA08832.2;KYB24934.1 KEGG: 00500+2.4.1.15 Starch and sucrose metabolism 2 KYB27852.1;EFA02222.2 KEGG: 00052+3.2.1.23 Galactose metabolism 9 EEZ99316.1;KYB26528.1;EEZ99315.1;EFA07841.1;EEZ97806.1;EFA07843.2;EFA06933.2;EFA04110.1;EFA07842.1 KEGG: 00710+5.3.1.1 Carbon fixation in photosynthetic organisms 1 EFA01748.1 KEGG: 00900+1.1.1.34 Terpenoid backbone biosynthesis 2 KYB27676.1;EFA06636.1 KEGG: 00281+4.2.1.17 Geraniol degradation 1 EFA04382.1 MetaCyc: PWY-7894 Procollagen hydroxylation and glycosylation 2 EEZ97485.1;EEZ97484.1 Reactome: R-HSA-176412 Phosphorylation of the APC/C 12 KYB25814.1;EEZ97989.1;EFA01569.1;EEZ97189.1;KYB27271.1;EEZ99272.2;EFA00073.1;EFA04231.1;KYB27187.1;EFA01854.1;EEZ98849.2;EEZ98737.1 Reactome: R-HSA-5628897 TP53 Regulates Metabolic Genes 43 EFA02004.1;EFA09197.2;KYB26900.1;EFA11005.2;EFA08972.2;EFA00676.2;KYB25778.1;EFA02019.1;EFA07471.1;EFA08847.1;EFA01361.1;EFA00352.1;EEZ97697.1;EFA02668.2;EFA07410.1;EFA10817.2;EFA09042.2;EFA02105.1;EFA07964.1;KYB26000.1;KYB27349.1;KYB27348.1;EFA05396.1;EFA00138.1;EFA00450.1;EFA03068.1;EFA07505.2;EFA10149.1;EFA08461.1;EFA11037.2;EFA07687.2;EFA12722.1;EFA12825.1;EFA09869.1;EEZ99978.2;EFA07587.1;EFA04626.2;EFA09095.1;EFA07586.1;EFA11590.1;KYB25999.1;EFA07588.1;EFA08214.1 MetaCyc: PWY-5973 Cis-vaccenate biosynthesis 7 EEZ97866.2;EFA11365.1;EFA05248.1;EFA05203.2;EFA05204.2;EFA05249.2;EFA05201.1 KEGG: 00240+3.1.3.5 Pyrimidine metabolism 1 EFA01792.1 MetaCyc: PWY-7456 Beta-(1,4)-mannan degradation 2 EFA01794.1;EFA07975.2 Reactome: R-HSA-194840 Rho GTPase cycle 66 KYB28979.1;EFA08404.1;KYB29836.1;EEZ98156.1;EFA11444.1;KYB25697.1;EFA09929.2;EFA00242.2;EFA11619.2;EFA03253.1;EFA06966.2;KYB25306.1;KYB28880.1;EFA00372.1;KYB27183.1;EFA13370.2;EFA13240.1;KYB29837.1;EFA06292.1;EFA07463.2;KYB28152.1;EFA04536.1;KYB29835.1;EFA09021.1;EEZ98803.1;KYB27086.1;KYB28980.1;KYB28883.1;EEZ99260.1;EFA00987.1;KYB25669.1;EFA06518.2;EFA10257.1;KYB26778.1;KYB28978.1;KXZ75734.1;EFA11249.1;EFA11099.2;EEZ99936.1;KYB29649.1;KYB24949.1;EEZ97169.2;KYB28884.1;KYB25265.1;EFA11443.1;KYB29839.1;EFA01222.2;EFA10155.2;KXZ75737.1;KYB29838.1;EFA01887.1;EFA00376.1;KYB25695.1;KYB27184.1;KYB29656.1;EFA10741.1;EFA11023.2;EFA11413.2;EFA01250.1;KYB27085.1;KXZ75736.1;KYB29823.1;EFA06578.1;EFA01951.2;EFA10998.2;KYB28879.1 MetaCyc: PWY-6803 Phosphatidylcholine acyl editing 25 EFA11062.1;KYB29358.1;KYB27221.1;KYB26689.1;EFA12460.1;EFA11061.1;EFA11812.1;KYB27219.1;EFA12309.1;EFA13680.1;EEZ98801.1;EEZ99784.2;EFA12575.1;EFA07860.2;KXZ75683.1;EFA09487.1;EFA12278.1;EFA09107.1;EFA05083.2;EFA03430.2;EFA12193.1;KYB27220.1;EFA13468.1;EFA07968.1;EFA08691.1 KEGG: 00071+2.3.1.21 Fatty acid degradation 1 EEZ99701.1 KEGG: 00510+2.4.1.68 N-Glycan biosynthesis 2 EFA02784.1;KYB27749.1 MetaCyc: PWY-6983 Threo-tetrahydrobiopterin biosynthesis 2 EFA13034.1;EFA05403.1 Reactome: R-HSA-112382 Formation of RNA Pol II elongation complex 37 EFA07302.1;EFA03559.1;EFA02310.1;EFA07055.2;EFA04061.1;EEZ98143.1;EEZ98144.2;EFA06469.1;KYB25207.1;EFA05896.1;EFA05446.1;EFA00328.1;EFA07148.1;EEZ97363.1;EFA08590.1;EFA06560.1;EEZ97432.2;EFA05606.1;EEZ99586.2;KYB29064.1;EFA10288.1;EFA12997.1;EFA00606.1;EFA00603.1;EFA07031.1;EEZ97398.2;KYB28470.1;EFA00018.1;EFA07995.2;EFA00397.1;EFA03550.1;EFA03150.1;KYB26001.1;EFA10605.2;EFA05226.1;KYB25378.1;KYB25152.1 KEGG: 00030+1.1.1.49 Pentose phosphate pathway 2 KYB27681.1;EFA03565.2 MetaCyc: PWY-6362 1D-myo-inositol hexakisphosphate biosynthesis II (mammalian) 3 EFA10622.1;KYB25213.1;EFA02124.1 Reactome: R-HSA-113507 E2F-enabled inhibition of pre-replication complex formation 7 EFA06929.1;EFA03157.1;EFA05162.2;EFA10460.1;EFA11188.2;KYB29174.1;EFA06374.2 Reactome: R-HSA-499943 Interconversion of nucleotide di- and triphosphates 25 EFA03825.1;EFA08015.1;EFA11748.1;EFA08206.2;EFA11497.1;EFA02202.1;EEZ99788.2;EFA00963.1;EFA00341.1;EEZ99726.1;EFA03918.2;EFA05847.1;EFA08094.1;EFA11131.1;EFA03917.1;EFA08711.2;EFA06480.1;KYB29097.1;KYB28254.1;EFA11124.1;KYB27609.1;EFA06562.1;EFA02095.1;EFA03645.2;EFA02203.1 KEGG: 00710+4.1.2.13 Carbon fixation in photosynthetic organisms 1 EFA04932.1 KEGG: 00960+2.6.1.1 Tropane, piperidine and pyridine alkaloid biosynthesis 3 EFA03109.1;EFA04122.1;KYB27212.1 Reactome: R-HSA-69231 Cyclin D associated events in G1 12 EFA06247.2;KYB29360.1;EFA06469.1;EFA01848.1;EFA02374.1;KYB27934.1;EFA09573.1;EFA12953.2;EFA02110.1;EFA07055.2;KYB29359.1;EFA02847.1 Reactome: R-HSA-1482839 Acyl chain remodelling of PE 8 EFA05083.2;KYB27220.1;EFA03430.2;EFA08691.1;KYB27219.1;EEZ98801.1;KYB27221.1;EEZ99784.2 KEGG: 00670+2.1.2.2 One carbon pool by folate 1 KYB25818.1 Reactome: R-HSA-983231 Factors involved in megakaryocyte development and platelet production 23 EFA03420.2;EFA03827.2;KYB27228.1;KYB25596.1;EFA03383.2;KYB26602.1;EFA06381.2;EFA10254.2;EEZ99469.1;EFA10548.1;EFA09534.1;EFA06457.1;EFA02124.1;EFA09305.2;EFA05273.2;KYB25393.1;KYB25392.1;EFA12165.2;EFA03253.1;EFA04619.2;KYB27132.1;KYB28779.1;KXZ75802.1 Reactome: R-HSA-442742 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling 2 KYB29263.1;EEZ98563.1 KEGG: 00030+2.7.6.1 Pentose phosphate pathway 2 EFA07775.1;EFA00168.2 KEGG: 00970+6.1.1.21 Aminoacyl-tRNA biosynthesis 1 EFA02605.2 Reactome: R-HSA-73930 Abasic sugar-phosphate removal via the single-nucleotide replacement pathway 3 KXZ75899.1;EFA12889.2;KYB26857.1 Reactome: R-HSA-3000497 Scavenging by Class H Receptors 6 EFA11302.1;KYB29706.1;KYB29705.1;KYB29704.1;KYB26997.1;EFA11425.1 Reactome: R-HSA-373080 Class B/2 (Secretin family receptors) 17 KYB28973.1;EFA11738.1;EFA09255.1;EFA12664.1;EFA04620.2;EFA01325.1;KYB26594.1;EFA07553.2;EFA12665.2;EFA04661.2;EFA04621.2;EFA07476.1;EFA04660.2;EFA04668.1;EFA04653.1;EFA09161.1;EEZ98485.1 Reactome: R-HSA-5579007 Defective ACY1 causes encephalopathy 2 EFA10313.1;KYB25257.1 KEGG: 00640+6.4.1.2 Propanoate metabolism 1 EFA05436.2 Reactome: R-HSA-168325 Viral Messenger RNA Synthesis 29 EFA03859.1;EFA05896.1;KYB28401.1;EFA01782.2;EFA01249.2;KYB29364.1;KYB29271.1;EFA07823.1;KYB26001.1;EFA04928.2;EFA06560.1;EFA03550.1;EFA03150.1;EEZ98695.2;KYB25152.1;KYB28630.1;EFA05226.1;EFA00605.1;EFA05993.1;KYB29624.1;EFA11141.2;EFA09537.1;EEZ97398.2;EEZ97868.2;EFA11447.2;EFA07031.1;EFA00581.2;KYB28470.1;EFA03584.1 KEGG: 00380+1.14.14.1 Tryptophan metabolism 1 EFA05733.1 Reactome: R-HSA-2453902 The canonical retinoid cycle in rods (twilight vision) 2 KYB28295.1;EEZ99723.1 Reactome: R-HSA-111459 Activation of caspases through apoptosome-mediated cleavage 5 EFA01361.1;EFA08214.1;KYB27348.1;EEZ98372.1;KYB27349.1 KEGG: 00680+4.1.2.13 Methane metabolism 1 EFA04932.1 KEGG: 00740+2.7.1.26 Riboflavin metabolism 1 EFA06175.2 Reactome: R-HSA-198933 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell 2 KYB28383.1;KYB28382.1 MetaCyc: PWY-7344 UDP-alpha-D-galactose biosynthesis 3 EFA06422.2;KYB26631.1;EFA06670.2 KEGG: 00010+1.2.1.12 Glycolysis / Gluconeogenesis 2 EFA07763.1;EFA08517.1 KEGG: 00983+1.17.4.1 Drug metabolism - other enzymes 3 EFA03825.1;EFA02202.1;EFA02203.1 Reactome: R-HSA-1660514 Synthesis of PIPs at the Golgi membrane 5 EEZ98191.1;EFA06197.2;EFA00380.1;KYB26275.1;KYB26276.1 Reactome: R-HSA-201722 Formation of the beta-catenin:TCF transactivating complex 15 KYB28557.1;KYB28977.1;KYB29349.1;EEZ97432.2;KYB28559.1;EFA02211.1;KYB24563.1;EEZ99317.2;KYB28558.1;EFA11241.1;KYB28556.1;KYB28976.1;EFA03559.1;EFA09469.1;EFA02517.2 Reactome: R-HSA-2871809 FCERI mediated Ca+2 mobilization 6 EFA11212.2;KYB24949.1;EEZ97169.2;KXZ75916.1;EFA12319.2;KYB29732.1 MetaCyc: PWY-6556 Pyrimidine ribonucleosides salvage II 1 EFA08865.1 Reactome: R-HSA-2682334 EPH-Ephrin signaling 3 EFA11555.2;EFA07434.1;KYB26081.1 KEGG: 00051+4.2.1.47 Fructose and mannose metabolism 1 EFA01082.1 KEGG: 00950+2.6.1.5 Isoquinoline alkaloid biosynthesis 1 EFA03251.1 MetaCyc: PWY-6853 Ethylene biosynthesis II (microbes) 1 EFA05239.1 Reactome: R-HSA-389977 Post-chaperonin tubulin folding pathway 7 EEZ99348.1;EEZ97218.1;EFA02681.1;EEZ97256.1;EEZ97891.1;EEZ99331.1;EEZ97229.1 Reactome: R-HSA-8876493 InlA-mediated entry of Listeria monocytogenes into host cells 3 EFA02110.1;KYB29359.1;KYB29360.1 Reactome: R-HSA-1234174 Cellular response to hypoxia 1 EFA01284.1 MetaCyc: PWY-7728 (4Z,7Z,10Z,13Z,16Z)-docosa-4,7,10,13,16-pentaenoate biosynthesis II (4-desaturase) 2 EFA05143.1;EFA03551.1 KEGG: 04151+2.7.11.1 PI3K-Akt signaling pathway 55 EFA06330.1;EFA05002.2;KYB27919.1;KYB26173.1;EFA11391.2;EFA00691.2;EFA00805.1;EFA00476.1;EFA13584.2;KYB25762.1;KYB27402.1;EEZ98563.1;KYB28438.1;EFA08613.1;KYB28374.1;EFA11184.1;EFA11019.1;KYB28836.1;KYB28439.1;KYB29263.1;EEZ99162.2;EFA07902.1;EFA02123.1;EFA04100.2;EFA07410.1;KYB28837.1;KYB27138.1;EFA05720.1;KYB28437.1;KYB27978.1;EEZ99828.2;EFA04406.2;EFA10720.1;KYB25791.1;KYB29873.1;EFA11787.2;EFA02105.1;EFA03058.1;EFA07964.1;EEZ98574.2;EFA02342.2;EEZ97987.1;EFA10912.2;EFA00152.1;EFA10048.1;EFA08276.1;EFA08636.2;EFA07752.1;EFA11394.1;EFA00769.1;KYB27979.1;KYB28376.1;EFA01876.2;KYB28377.1;KYB28375.1 Reactome: R-HSA-8849175 Threonine catabolism 2 EFA08585.1;EFA02050.1 KEGG: 00480+1.17.4.1 Glutathione metabolism 3 EFA03825.1;EFA02202.1;EFA02203.1 KEGG: 00830+1.1.1.1 Retinol metabolism 1 EEZ98950.2 MetaCyc: PWY-6731 Starch degradation III 1 EFA02541.1 Reactome: R-HSA-8854050 FBXL7 down-regulates AURKA during mitotic entry and in early mitosis 41 EEZ97876.1;KYB27556.1;KYB26764.1;EFA03341.1;EFA02847.1;EFA06741.1;EFA11079.1;EFA06519.1;EFA08664.1;EFA06200.1;EFA02110.1;KYB27557.1;KYB29360.1;EEZ99493.1;EFA08911.2;EFA02345.1;EFA13218.1;KYB26545.1;EFA07110.1;EFA05912.1;KYB29359.1;EEZ99004.1;EFA05833.1;KYB24713.1;EFA05370.2;EFA04284.1;KYB25309.1;EEZ97564.1;EFA07261.2;EFA09524.2;EFA08798.1;EFA05865.1;EFA04054.1;EFA07659.2;EFA05871.2;EFA09518.2;EFA08601.1;EFA03019.1;EFA05105.1;EFA02331.1;EEZ98185.1 KEGG: 00970+6.1.1.20 Aminoacyl-tRNA biosynthesis 4 EFA07176.1;EEZ97297.1;EFA05368.1;KYB29382.1 Reactome: R-HSA-8953750 Transcriptional Regulation by E2F6 5 EFA00645.1;EEZ98372.1;EFA02865.1;EFA02866.1;EFA01593.1 KEGG: 00270+2.6.1.5 Cysteine and methionine metabolism 1 EFA03251.1 Reactome: R-HSA-426486 Small interfering RNA (siRNA) biogenesis 9 EFA04626.2;EFA11550.2;EFA09197.2;KYB25999.1;KYB26397.1;EFA07522.2;KYB26000.1;EFA11590.1;EEZ99277.1 KEGG: 00410+1.3.3.6 beta-Alanine metabolism 3 EFA09569.1;EFA09425.1;EFA11530.1 KEGG: 00564+3.1.1.7 Glycerophospholipid metabolism 1 EEZ99262.2 Reactome: R-HSA-203615 eNOS activation 1 EFA08713.1 Reactome: R-HSA-9665251 Resistance of ERBB2 KD mutants to lapatinib 1 EFA03198.1 Reactome: R-HSA-9645460 Alpha-protein kinase 1 signaling pathway 4 KYB29360.1;EFA02851.1;EFA02110.1;KYB29359.1 Reactome: R-HSA-156581 Methylation 1 EEZ97278.1 Reactome: R-HSA-69481 G2/M Checkpoints 40 EFA02110.1;KYB27557.1;KYB29360.1;EEZ99493.1;EFA08911.2;EFA13218.1;EFA02345.1;EEZ97876.1;KYB27556.1;KYB26764.1;EFA03341.1;EFA06741.1;EFA11079.1;EFA06519.1;EFA08664.1;EFA06200.1;EEZ97564.1;EFA07261.2;EFA09524.2;EFA08798.1;EFA05865.1;EFA04054.1;EFA07659.2;EFA05871.2;EFA09518.2;EFA08601.1;EFA03019.1;EFA05105.1;EFA02331.1;EEZ98185.1;KYB26545.1;EFA07110.1;KYB29359.1;EFA05912.1;EFA05833.1;EEZ99004.1;KYB24713.1;EFA05370.2;KYB25309.1;EFA04284.1 Reactome: R-HSA-5676590 NIK-->noncanonical NF-kB signaling 43 EEZ97876.1;KYB27556.1;KYB26764.1;EFA03341.1;EFA02847.1;EFA06741.1;EFA11079.1;EFA06519.1;EEZ99274.1;EFA08664.1;EFA06200.1;EFA02110.1;KYB27557.1;KYB29360.1;EEZ99493.1;EFA08911.2;EFA13218.1;EFA02345.1;KYB26545.1;EFA07110.1;EFA05912.1;KYB29359.1;EEZ99004.1;EFA05833.1;KYB24713.1;EFA05370.2;EFA11744.1;EFA04284.1;KYB25309.1;EEZ97564.1;EFA07261.2;EFA09524.2;EFA08798.1;EFA05865.1;EFA04054.1;EFA07659.2;EFA05871.2;EFA09518.2;EFA08601.1;EFA03019.1;EFA05105.1;EEZ98185.1;EFA02331.1 Reactome: R-HSA-5633231 Defective ALG14 causes congenital myasthenic syndrome (ALG14-CMS) 2 EEZ98644.1;EFA00490.1 KEGG: 00053+3.1.1.17 Ascorbate and aldarate metabolism 2 EFA03133.1;EFA10016.2 Reactome: R-HSA-6781823 Formation of TC-NER Pre-Incision Complex 28 EFA10422.1;EFA07031.1;EFA06469.1;KYB29360.1;KYB28470.1;EFA00018.1;KYB26826.1;EFA08119.1;EFA02310.1;EFA07055.2;EFA02110.1;EFA09688.1;EFA07302.1;KYB26824.1;EFA06560.1;KYB26001.1;EFA03150.1;EFA05226.1;KYB25378.1;EFA05896.1;EFA12724.1;KYB29359.1;EFA03569.1;KYB25334.1;EFA12663.1;EFA07762.1;KYB25639.1;EFA00328.1 Reactome: R-HSA-189085 Digestion of dietary carbohydrate 89 KYB29334.1;EFA00423.1;EFA06311.1;KYB26215.1;KYB26217.1;EFA02438.2;EEZ97295.1;EFA08990.1;EFA11727.2;EFA06943.1;EFA02771.1;KYB27624.1;KYB25108.1;KYB26070.1;EFA06357.1;KYB29331.1;EFA13323.2;EEZ97331.1;EFA11450.2;EEZ97330.1;EFA02439.2;KYB28954.1;KYB25868.1;EFA10488.1;EFA06693.1;EFA11132.2;EFA07840.1;KYB26219.1;EFA05130.2;KYB29665.1;EEZ98206.2;EFA00424.1;EFA05323.2;KYB26069.1;KYB26487.1;EEZ98452.1;EFA08991.1;EFA08993.1;KYB29333.1;EFA11183.1;EEZ98786.1;KYB26615.1;EFA08056.1;EFA10333.2;EFA02013.1;EFA10939.1;EEZ98161.1;KYB27970.1;KYB29169.1;EFA08992.1;EEZ98454.1;EFA07894.1;KYB26603.1;KYB29170.1;KYB26600.1;EFA00422.1;KYB26427.1;KYB26216.1;KYB29332.1;EFA09604.2;EEZ98451.1;KYB29695.1;KYB26426.1;EFA05441.1;KYB27623.1;EFA07893.1;KYB28316.1;KYB26843.1;EFA03957.2;EFA13447.2;EEZ98450.1;KYB28956.1;KYB28955.1;EFA06942.1;EEZ97328.1;KYB27971.1;EEZ97329.1;KYB26614.1;EEZ98866.1;EFA03956.1;EFA00965.2;EEZ97505.1;EFA06939.2;EEZ98162.2;KYB29800.1;EFA10789.1;KYB26613.1;EFA04786.1;EEZ97929.1 Reactome: R-HSA-390696 Adrenoceptors 2 EEZ99218.2;EFA10678.2 Reactome: R-HSA-5221030 TET1,2,3 and TDG demethylate DNA 2 KYB27563.1;EFA11876.2 Reactome: R-HSA-390648 Muscarinic acetylcholine receptors 2 EEZ99326.2;KYB29383.1 Reactome: R-HSA-5620912 Anchoring of the basal body to the plasma membrane 19 EEZ97959.1;EFA04919.1;EFA07920.2;EEZ98528.1;EFA08550.1;KYB27666.1;EFA08377.1;KYB28881.1;EFA02136.2;EFA06332.2;EFA03783.1;KYB25597.1;KYB26566.1;EFA10255.2;EFA05098.1;KYB28459.1;KYB28460.1;EFA09381.2;KYB25744.1 MetaCyc: PWY-3841 Folate transformations II (plants) 7 EFA02095.1;EFA07237.1;EFA11748.1;EFA07809.2;EFA07236.1;EFA09131.1;EFA07671.2 Reactome: R-HSA-375280 Amine ligand-binding receptors 1 EFA10037.1 MetaCyc: PWY-6898 Thiamine salvage III 2 KYB29167.1;EEZ98443.2 KEGG: 00562+2.7.1.150 Inositol phosphate metabolism 1 EFA00380.1 KEGG: 00240+3.6.1.17 Pyrimidine metabolism 1 KYB26853.1 Reactome: R-HSA-5423646 Aflatoxin activation and detoxification 6 KYB25257.1;KYB27245.1;EEZ99578.1;EFA08612.1;KYB27246.1;EFA10313.1 Reactome: R-HSA-196025 Formation of annular gap junctions 3 EFA02270.2;EFA09781.1;EFA04947.1 Reactome: R-HSA-5083629 Defective POMT2 causes MDDGA2, MDDGB2 and MDDGC2 4 EFA06291.1;EFA03006.2;KYB26307.1;KYB26306.1 KEGG: 00130+2.1.1.163 Ubiquinone and other terpenoid-quinone biosynthesis 2 KYB27131.1;EFA05173.2 Reactome: R-HSA-4641258 Degradation of DVL 40 EFA08601.1;EFA09518.2;EFA05871.2;EFA07659.2;EFA02331.1;EEZ98185.1;EFA05105.1;EFA03019.1;EFA07261.2;EEZ97564.1;EFA05865.1;EFA04054.1;EFA08798.1;EFA09524.2;KYB24713.1;EFA05833.1;EEZ99004.1;EFA04284.1;KYB25309.1;EFA05370.2;KYB26545.1;EFA05912.1;KYB29359.1;EFA07110.1;KYB29360.1;KYB27557.1;EFA13218.1;EFA02345.1;EFA08911.2;EEZ99493.1;EFA02110.1;EFA06519.1;EFA11079.1;EFA06741.1;EFA06200.1;EFA08664.1;KYB27556.1;EEZ97876.1;EFA03341.1;KYB26764.1 Reactome: R-HSA-2980766 Nuclear Envelope Breakdown 1 EFA05796.2 Reactome: R-HSA-72702 Ribosomal scanning and start codon recognition 50 EFA03441.1;EFA02515.1;EFA08849.1;EEZ98503.1;EFA00505.1;EFA00209.1;EFA11360.1;EFA10123.1;KYB25876.1;KYB29360.1;EFA05867.1;EFA01765.1;KYB27801.1;EFA11293.1;KYB26424.1;EFA04159.1;EFA06707.1;EFA09970.1;EFA00935.2;EEZ99023.1;EFA05373.1;EEZ97313.1;EFA06382.1;EFA10201.2;EFA08366.2;EFA09067.1;EEZ98728.1;EEZ97645.1;EEZ99942.1;EFA01611.1;EFA10249.1;EFA02554.1;EFA09390.1;EFA04093.1;EEZ99635.1;EFA06341.1;EEZ98852.1;EFA07317.1;EFA08069.1;KYB29359.1;EFA04453.1;EFA01900.1;EFA13692.2;EFA05170.2;EFA06534.1;EFA07164.1;EEZ97224.1;EEZ99099.1;EFA07141.1;EFA01104.1 Reactome: R-HSA-156590 Glutathione conjugation 6 EFA00963.1;EFA04060.1;EFA06896.1;EEZ99479.1;EEZ99480.1;EFA08560.1 Reactome: R-HSA-176187 Activation of ATR in response to replication stress 31 EFA06047.1;EFA05648.1;EFA08916.1;EEZ97375.1;KYB27483.1;EFA06374.2;KYB25740.1;EFA11188.2;EFA13575.1;EFA12891.1;EFA09906.2;EFA03620.1;EFA06648.2;EFA03157.1;EEZ97345.1;EFA06449.1;KYB26668.1;EFA02756.1;EFA11589.2;EEZ97925.1;EFA05162.2;EFA12381.1;EFA10460.1;EFA12420.2;EFA06929.1;KYB25791.1;KYB29174.1;EFA04934.2;EEZ97575.1;EFA03095.1;EFA09711.2 Reactome: R-HSA-437239 Recycling pathway of L1 16 EEZ97891.1;EFA11263.1;EFA09781.1;EFA06187.1;EEZ99331.1;KYB26625.1;EFA09822.2;EFA04833.1;EEZ98563.1;EFA11292.1;EEZ97229.1;EEZ99070.2;EFA06663.1;KYB26929.1;KYB29263.1;EEZ99348.1 Reactome: R-HSA-210744 Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells 4 EEZ99435.2;EFA02517.2;EEZ99094.1;EFA04470.1 MetaCyc: PWY-7664 Oleate biosynthesis IV (anaerobic) 7 EFA05203.2;EFA05201.1;EFA05249.2;EFA05204.2;EFA11365.1;EEZ97866.2;EFA05248.1 KEGG: 04660+2.7.10.2 T cell receptor signaling pathway 13 KYB24940.1;EFA06030.2;KYB28308.1;KYB24938.1;KYB29798.1;EFA10048.1;KYB26419.1;KYB24939.1;EFA13584.2;EFA11294.2;KYB28309.1;EFA05853.2;EFA05807.2 Reactome: R-HSA-4551638 SUMOylation of chromatin organization proteins 25 EFA01782.2;EFA01249.2;KYB28401.1;EFA03859.1;EFA07823.1;KYB29271.1;KYB29364.1;EFA04928.2;EFA01340.2;EFA00645.1;EFA02026.1;KYB28630.1;EEZ98695.2;EFA05993.1;EFA00605.1;EFA11141.2;EFA09537.1;KYB29624.1;EEZ97868.2;EFA11447.2;KYB24563.1;EFA03584.1;KYB28494.1;EFA10915.2;EFA00581.2 Reactome: R-HSA-4570464 SUMOylation of RNA binding proteins 19 EEZ97868.2;EFA11447.2;EFA00581.2;EFA03584.1;EFA00605.1;EFA05993.1;KYB29624.1;EFA11141.2;EFA09537.1;EFA04928.2;EEZ98695.2;KYB28630.1;EFA03859.1;KYB28401.1;EFA01249.2;EFA01782.2;KYB29364.1;EFA07823.1;KYB29271.1 KEGG: 04070+2.7.4.24+2.7.4.21 Phosphatidylinositol signaling system 3 KYB26511.1;KYB26510.1;KYB26507.1 Reactome: R-HSA-9613829 Chaperone Mediated Autophagy 4 KYB29359.1;EFA02110.1;KYB29360.1;EFA04901.1 MetaCyc: PWY-6945 Cholesterol degradation to androstenedione I (cholesterol oxidase) 3 EFA05073.1;EFA08151.1;EFA04382.1 Reactome: R-HSA-111465 Apoptotic cleavage of cellular proteins 2 EFA04040.1;EFA13272.2 Reactome: R-HSA-4341670 Defective NEU1 causes sialidosis 1 KYB28573.1 Reactome: R-HSA-110314 Recognition of DNA damage by PCNA-containing replication complex 23 KYB26713.1;EFA03020.2;KYB28925.1;EFA02756.1;EFA03814.1;EFA07958.1;KYB27959.1;EFA02422.2;EFA09711.2;EFA06042.1;KYB29359.1;EFA12420.2;KYB25740.1;KYB29360.1;EFA12891.1;EFA09906.2;EFA08916.1;KYB28926.1;KYB27483.1;EFA08812.2;EFA06672.2;EFA02110.1;KYB25721.1 Reactome: R-HSA-9013700 NOTCH4 Activation and Transmission of Signal to the Nucleus 4 EFA07178.2;KYB27078.1;EFA04103.1;EFA05049.2 Reactome: R-HSA-450520 HuR (ELAVL1) binds and stabilizes mRNA 1 EFA09995.1 Reactome: R-HSA-450385 Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA 12 EFA03462.2;EFA05246.1;EFA06035.2;EFA02571.1;EFA06447.1;EFA06999.1;EEZ97803.1;EFA01958.1;EFA07836.1;EEZ98806.1;EEZ99918.1;EFA07181.2 Reactome: R-HSA-69202 Cyclin E associated events during G1/S transition 6 EFA06469.1;EFA02105.1;EFA08856.2;EFA01741.1;EFA07055.2;EFA02434.1 Reactome: R-HSA-8939245 RUNX1 regulates transcription of genes involved in BCR signaling 2 EFA03630.2;KYB27618.1 KEGG: 00564+2.7.8.11 Glycerophospholipid metabolism 1 EFA05079.1 KEGG: 00860+2.5.1.17 Porphyrin and chlorophyll metabolism 1 EFA10463.1 MetaCyc: PWY-7210 Pyrimidine deoxyribonucleotides biosynthesis from CTP 15 EFA11748.1;EFA08015.1;EFA03917.1;EFA07795.2;EFA00847.2;EEZ99726.1;EFA03825.1;EFA02095.1;EFA02203.1;EFA02202.1;KYB29374.1;KYB26165.1;EFA07171.1;EFA08206.2;EEZ98594.1 KEGG: 00270+1.13.11.20 Cysteine and methionine metabolism 1 EFA06970.1 MetaCyc: PWY-6692 Fe(II) oxidation 2 EEZ97735.1;EFA01233.1 KEGG: 00030+5.1.3.1 Pentose phosphate pathway 1 EEZ97576.1 KEGG: 00531+3.2.1.35 Glycosaminoglycan degradation 1 EFA05324.1 KEGG: 00270+1.13.11.54 Cysteine and methionine metabolism 2 EEZ99138.2;EEZ99144.1 MetaCyc: PWY-7619 Juniperonate biosynthesis 21 EFA10642.1;EEZ97311.1;EFA10641.2;KYB25455.1;EFA09795.1;KYB29213.1;EFA05474.1;KYB25229.1;EFA05473.2;KYB25454.1;EFA09796.1;EFA10643.2;EFA05143.1;KYB25453.1;EFA03551.1;EFA09483.1;EFA03752.1;EFA00083.2;KYB29211.1;EFA00084.1;EFA05977.1 KEGG: 00230+2.7.4.6 Purine metabolism 4 EEZ98594.1;KYB26165.1;EFA07171.1;EEZ99726.1 KEGG: 00230+2.7.4.10 Purine metabolism 1 EFA06480.1 KEGG: 00670+2.1.2.9 One carbon pool by folate 4 KYB29131.1;KYB25818.1;EEZ98405.2;EFA05437.1 Reactome: R-HSA-75035 Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex 2 EFA08461.1;EFA11005.2 MetaCyc: PWY-5972 Stearate biosynthesis I (animals) 19 EFA10643.2;EFA05473.2;KYB25454.1;EFA09796.1;KYB25229.1;EFA05474.1;KYB29213.1;EFA09795.1;KYB25455.1;EFA10641.2;EEZ97311.1;EFA10642.1;EFA05977.1;EFA00084.1;KYB29211.1;EFA00083.2;EFA03752.1;EFA09483.1;KYB25453.1 MetaCyc: PWY-7820 Teichuronic acid biosynthesis (B. subtilis 168) 1 KYB28935.1 Reactome: R-HSA-1592389 Activation of Matrix Metalloproteinases 1 EFA09264.2 MetaCyc: PWY-6664 Di-myo-inositol phosphate biosynthesis 1 EFA09280.1 Reactome: R-HSA-8939247 RUNX1 regulates transcription of genes involved in interleukin signaling 2 EFA03630.2;KYB27618.1 Reactome: R-HSA-2299718 Condensation of Prophase Chromosomes 4 EFA05577.2;EFA01238.1;EEZ98859.1;KYB24563.1 KEGG: 00052+3.5.1.25 Galactose metabolism 1 KYB27794.1 Reactome: R-HSA-171319 Telomere Extension By Telomerase 4 EFA13038.1;EFA05694.1;EFA09469.1;EFA10722.1 MetaCyc: PWY-5664 Erythro-tetrahydrobiopterin biosynthesis II 2 EFA05403.1;EFA13034.1 MetaCyc: PWY-621 Sucrose degradation III (sucrose invertase) 1 EFA07687.2 Reactome: R-HSA-168333 NEP/NS2 Interacts with the Cellular Export Machinery 21 EFA03859.1;KYB28401.1;EFA01249.2;EFA01782.2;KYB29364.1;KYB29271.1;EFA07823.1;EFA04928.2;EEZ98695.2;KYB28630.1;EFA00605.1;EFA05993.1;KYB29624.1;EFA11141.2;EFA09537.1;EFA10538.1;EEZ97868.2;EFA11447.2;EFA09995.1;EFA00581.2;EFA03584.1 Reactome: R-HSA-432047 Passive transport by Aquaporins 10 KYB27164.1;EEZ98804.1;EFA08519.2;EFA04049.2;EFA04048.2;EEZ97427.2;EFA11295.1;EFA04046.1;KYB25143.1;KXZ75551.1 KEGG: 04070+2.7.1.159 Phosphatidylinositol signaling system 1 EFA02124.1 MetaCyc: PWY-8051 Anandamide biosynthesis I 35 EFA12193.1;EFA12309.1;EFA13680.1;EEZ99784.2;KXZ75683.1;EEZ97257.1;EFA04525.1;EFA06119.2;KYB27111.1;KYB26367.1;KYB27221.1;EFA12460.1;EFA09107.1;EFA12278.1;EFA05083.2;EFA03430.2;KYB27220.1;EFA07968.1;EFA13468.1;EFA08691.1;EFA07054.2;EEZ98801.1;KYB27110.1;EFA09975.1;EFA07860.2;EFA12575.1;EFA09487.1;EFA11061.1;EFA11812.1;KYB27219.1;EFA11062.1;KYB29358.1;EFA02132.1;EEZ97656.1;KYB26689.1 MetaCyc: PWY-6122 5-aminoimidazole ribonucleotide biosynthesis II 5 EFA11870.2;EFA02192.2;KYB25818.1;EEZ98112.1;EEZ97659.2 Reactome: R-HSA-191859 snRNP Assembly 35 KYB28595.1;EFA05993.1;EFA01612.2;EFA09904.1;EEZ98144.2;EEZ98143.1;EFA00803.1;EFA11447.2;KYB28596.1;EFA01782.2;EFA03859.1;KYB29364.1;EFA00708.1;EFA05976.1;EEZ98695.2;EFA00605.1;EFA12926.2;EFA09537.1;EFA11141.2;KYB29624.1;EEZ97868.2;EFA03584.1;EFA04291.1;EFA00581.2;EFA01249.2;KYB28401.1;EFA07823.1;KYB29271.1;EEZ99905.1;EFA00806.2;EFA05269.2;EFA04928.2;KYB28630.1;KYB25464.1;EFA02533.1 KEGG: 00604+3.2.1.23 Glycosphingolipid biosynthesis - ganglio series 9 EFA06933.2;EFA07843.2;EEZ97806.1;EFA07842.1;EFA04110.1;EEZ99315.1;EEZ99316.1;KYB26528.1;EFA07841.1 Reactome: R-HSA-8964208 Phenylalanine metabolism 4 EFA08343.2;EEZ98638.1;EFA08342.2;EEZ99507.1 Reactome: R-HSA-8963889 Assembly of active LPL and LIPC lipase complexes 4 EFA12890.2;EFA00011.2;EEZ98063.1;KYB28740.1 Reactome: R-HSA-1614635 Sulfur amino acid metabolism 2 EFA01862.1;EFA03390.1 Reactome: R-HSA-2173791 TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) 5 EFA07576.2;KYB29359.1;EFA02110.1;EEZ97734.1;KYB29360.1 KEGG: 00561+2.3.1.20 Glycerolipid metabolism 3 EFA04221.1;EFA08670.2;KYB25893.1 KEGG: 00710+3.1.3.11 Carbon fixation in photosynthetic organisms 2 KYB27612.1;EEZ98675.1 MetaCyc: PWY-7511 Protein ubiquitination 113 EFA09444.1;EFA10984.1;EFA03156.1;EFA06336.1;KYB24961.1;KYB26439.1;EEZ97366.1;KYB28317.1;KYB25901.1;EEZ97459.2;EEZ98701.1;EFA06131.1;EFA09449.1;EEZ98089.2;EFA05194.1;KYB25931.1;KYB26512.1;KYB25358.1;EFA06125.1;EEZ99810.1;EFA06060.1;EFA04853.2;EFA12113.1;EFA00429.2;EFA03967.1;EFA07884.1;EFA04916.1;EFA09029.1;EFA08658.1;KYB26452.1;EFA06061.2;KYB24712.1;KYB29474.1;EFA03437.1;EFA01329.1;EFA09347.1;EFA10118.1;EFA13414.2;EEZ97228.2;EFA06019.1;KYB26050.1;EEZ97381.1;KYB25563.1;EFA10490.1;KYB26451.1;EFA09828.2;KYB26669.1;KYB25930.1;KYB26048.1;KYB25334.1;EFA11491.1;EFA09707.1;EFA11211.1;EFA08807.2;KYB26730.1;KYB26391.1;EFA00158.1;EFA03438.1;EFA06066.2;EFA11345.1;EFA06072.2;EEZ98497.1;EFA02827.2;EFA08143.2;KYB27259.1;EFA10928.1;EFA09680.1;EFA09947.1;EFA08997.2;EFA03528.1;EFA03940.2;EFA00574.1;KYB27620.1;KYB25357.1;KYB28908.1;EFA06399.2;EEZ98478.1;EEZ98854.2;EFA04169.1;EFA07231.2;EFA04324.2;EFA02989.2;EFA00388.1;EFA01120.1;EFA01492.2;EFA09218.1;EFA08149.1;KYB24996.1;EFA02851.1;EFA02147.2;KYB26049.1;EEZ99199.1;KYB25356.1;EEZ97760.2;EFA03675.1;KYB25888.1;EFA05477.1;EFA10186.1;EFA10943.2;KYB25932.1;EFA06528.1;EFA07520.2;KYB27535.1;KYB29416.1;KYB27699.1;KYB25736.1;EFA06952.1;EFA06236.2;EFA08890.2;KYB28818.1;KYB29735.1;KYB26671.1;KYB26108.1 Reactome: R-HSA-202424 Downstream TCR signaling 44 EFA02110.1;KYB29360.1;EFA02851.1;KYB27557.1;EFA02345.1;EFA13218.1;EFA08911.2;EEZ99493.1;KYB27556.1;EEZ97876.1;EFA02847.1;EFA03341.1;KYB26764.1;EFA06519.1;EFA11079.1;EFA06741.1;EFA06200.1;EFA08664.1;EEZ99274.1;EFA07261.2;EEZ97564.1;EFA05865.1;EFA04054.1;EFA08798.1;EFA09524.2;EFA08601.1;EFA09518.2;EFA05871.2;EFA07659.2;EEZ98185.1;EFA02331.1;EFA00152.1;EFA05105.1;EFA03019.1;KYB26545.1;KYB29359.1;EFA05912.1;EFA07110.1;KYB24713.1;EFA05833.1;EEZ99004.1;EFA04284.1;KYB25309.1;EFA05370.2 KEGG: 00790+1.5.1.3 Folate biosynthesis 1 EFA07671.2 Reactome: R-HSA-68949 Orc1 removal from chromatin 60 EFA05865.1;EFA04054.1;EFA06648.2;EFA03620.1;EFA09524.2;EFA08798.1;EEZ97564.1;EFA07261.2;KYB26668.1;EFA06449.1;EEZ98185.1;EFA02331.1;EFA06047.1;EFA03019.1;EFA05105.1;EFA08601.1;EFA06374.2;EFA05871.2;EFA07659.2;EFA09518.2;KYB29359.1;EFA05912.1;EFA07110.1;EFA06929.1;EFA00549.1;KYB26545.1;KYB29174.1;EFA03095.1;EFA04284.1;KYB25309.1;EFA05370.2;EEZ97925.1;EFA05833.1;EEZ99004.1;KYB24713.1;EFA05162.2;EFA12381.1;EFA10460.1;EFA02110.1;EFA03157.1;EFA08911.2;EFA02345.1;EFA13218.1;EEZ97375.1;EEZ99493.1;KYB29360.1;EFA13575.1;EFA11188.2;KYB27557.1;EFA02847.1;KYB26764.1;EFA03341.1;EEZ97575.1;KYB27556.1;EEZ97876.1;EFA06200.1;EFA08664.1;EFA11079.1;EFA06519.1;EFA06741.1 Reactome: R-HSA-5467333 APC truncation mutants are not K63 polyubiquitinated 1 EFA13272.2 KEGG: 00760+3.6.1.9 Nicotinate and nicotinamide metabolism 2 EFA04414.1;EFA03919.1 Reactome: R-HSA-174084 Autodegradation of Cdh1 by Cdh1:APC/C 50 EFA05865.1;KYB27271.1;EEZ99272.2;EFA04054.1;EFA08798.1;EFA01854.1;EFA09524.2;EEZ97564.1;EFA02331.1;EEZ98185.1;EFA05105.1;EFA03019.1;EFA08601.1;EFA09518.2;EFA07659.2;EFA05871.2;KYB29359.1;EFA05912.1;EFA07110.1;KYB27187.1;KYB25814.1;KYB26545.1;EFA01569.1;EFA04284.1;KYB25309.1;EFA05370.2;KYB24713.1;EEZ99004.1;EFA05833.1;EFA02110.1;EFA04231.1;EEZ97989.1;EFA02345.1;EFA13218.1;EFA08911.2;EEZ99493.1;KYB29360.1;KYB27557.1;EEZ98849.2;EEZ97189.1;EFA00073.1;EFA03341.1;KYB27556.1;EEZ97876.1;EFA06200.1;EFA08664.1;EFA06519.1;EFA11079.1;EEZ98737.1;EFA06741.1 MetaCyc: PWY-3781 Aerobic respiration I (cytochrome c) 6 EFA10709.2;EFA02829.1;EEZ97735.1;EFA09226.1;EFA01233.1;EFA04683.1 KEGG: 00520+3.5.1.25 Amino sugar and nucleotide sugar metabolism 1 KYB27794.1 KEGG: 04150+2.7.1.153 mTOR signaling pathway 1 EFA09848.2 MetaCyc: PWY-5054 D-sorbitol biosynthesis I 1 EFA07687.2 Reactome: R-HSA-190840 Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane 12 EEZ97891.1;EFA11292.1;EFA04833.1;EFA09822.2;KYB26929.1;EFA06663.1;KYB26625.1;EEZ99348.1;EEZ97229.1;EFA06187.1;EEZ99331.1;EEZ99070.2 MetaCyc: PWY-5484 Glycolysis II (from fructose 6-phosphate) 21 EEZ98809.1;EFA08842.1;KYB24934.1;EFA07763.1;EEZ99016.2;EFA08228.2;EEZ98675.1;KYB24935.1;EFA11310.1;EFA08517.1;EFA05374.1;EFA01748.1;KYB27612.1;EFA08832.2;EFA09609.1;EFA10506.1;EEZ97193.2;EFA09610.1;EFA04932.1;KYB26002.1;KYB25941.1 MetaCyc: PWY-7219 Adenosine ribonucleotides de novo biosynthesis 12 EFA11131.1;EFA03917.1;KYB26701.1;EFA05847.1;EFA03918.2;EFA03645.2;KYB27609.1;EFA06562.1;EFA08776.1;EFA06480.1;KYB29097.1;EFA11124.1 Reactome: R-HSA-3232118 SUMOylation of transcription factors 1 EFA06716.1 KEGG: 00330+1.2.1.41+2.7.2.11 Arginine and proline metabolism 1 EEZ98981.2 Reactome: R-HSA-6814848 Glycerophospholipid catabolism 2 KYB29225.1;EEZ98531.2 MetaCyc: PWY-6840 Homoglutathione biosynthesis 1 EFA04528.1 MetaCyc: PWY-6366 D-myo-inositol (1,4,5,6)-tetrakisphosphate biosynthesis 1 EFA02124.1 KEGG: 00640+6.2.1.4 Propanoate metabolism 1 EFA11202.1 MetaCyc: PWY-5994 Palmitate biosynthesis (animals and fungi, cytoplasm) 7 EFA05203.2;EFA05249.2;EFA05201.1;EFA05204.2;EEZ97866.2;EFA11365.1;EFA05248.1 Reactome: R-HSA-1482801 Acyl chain remodelling of PS 8 EFA08691.1;KYB27219.1;KYB27220.1;EFA03430.2;EFA05083.2;KYB27221.1;EEZ99784.2;EEZ98801.1 Reactome: R-HSA-5625740 RHO GTPases activate PKNs 4 EFA11005.2;EFA08461.1;KYB28728.1;EFA00152.1 Reactome: R-HSA-380284 Loss of proteins required for interphase microtubule organization from the centrosome 15 EFA10255.2;EFA05098.1;KYB28459.1;EEZ98528.1;KYB27666.1;KYB28460.1;EFA09381.2;KYB25744.1;EEZ97959.1;EFA02136.2;EFA06332.2;EFA03783.1;EFA07920.2;KYB25597.1;KYB26566.1 KEGG: 00240+1.3.5.2 Pyrimidine metabolism 1 EEZ97344.2 Reactome: R-HSA-2730905 Role of LAT2/NTAL/LAB on calcium mobilization 1 EFA00152.1 Reactome: R-HSA-2022928 HS-GAG biosynthesis 5 EFA11584.2;EFA03870.1;EFA10381.1;EFA03369.2;KYB27316.1 Reactome: R-HSA-191273 Cholesterol biosynthesis 7 EEZ97847.2;EFA00378.2;EFA07280.1;KYB29328.1;EFA06636.1;EFA05256.2;KYB27676.1 Reactome: R-HSA-2393930 Phosphate bond hydrolysis by NUDT proteins 3 EFA09048.1;EFA08806.2;EEZ97187.1 Reactome: R-HSA-8875656 MET receptor recycling 2 EFA11162.1;EFA11143.1 KEGG: 00230+3.6.1.17 Purine metabolism 1 KYB26853.1 Reactome: R-HSA-392170 ADP signalling through P2Y purinoceptor 12 1 KYB25864.1 Reactome: R-HSA-5223345 Miscellaneous transport and binding events 3 EFA04241.1;EFA09585.1;EFA10650.1 KEGG: 00280+2.6.1.42 Valine, leucine and isoleucine degradation 1 EEZ98004.1 KEGG: 00020+6.2.1.5 Citrate cycle (TCA cycle) 5 EFA05014.1;EFA07160.1;EFA03750.1;EFA11202.1;EFA11129.1 KEGG: 00020+4.2.1.2 Citrate cycle (TCA cycle) 1 EFA03144.1 KEGG: 00625+1.1.1.1 Chloroalkane and chloroalkene degradation 1 EEZ98950.2 MetaCyc: PWY-5129 Sphingolipid biosynthesis (plants) 2 EFA12048.1;EFA05646.1 KEGG: 00471+3.5.1.2 D-Glutamine and D-glutamate metabolism 1 EFA11037.2 KEGG: 00982+1.14.14.1 Drug metabolism - cytochrome P450 1 EFA05733.1 KEGG: 00643+1.13.11.5 Styrene degradation 1 EFA07806.1 Reactome: R-HSA-5654706 FRS-mediated FGFR3 signaling 1 EFA09507.1 MetaCyc: PWY-7852 6-hydroxymethyl-dihydropterin diphosphate biosynthesis IV (Plasmodium) 1 EFA13034.1 MetaCyc: PWY-6538 Caffeine degradation III (bacteria, via demethylation) 1 EFA09973.1 KEGG: 00970+6.1.1.9 Aminoacyl-tRNA biosynthesis 2 EFA12616.1;EFA00421.1 KEGG: 00332+2.7.2.11 Carbapenem biosynthesis 1 EEZ98981.2 Reactome: R-HSA-2559586 DNA Damage/Telomere Stress Induced Senescence 6 EFA07487.1;KYB24563.1;EFA04568.2;EEZ98702.1;EFA11787.2;EFA05681.1 Reactome: R-HSA-450513 Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA 12 EFA01958.1;EFA07836.1;EEZ98806.1;EFA07181.2;EEZ99918.1;EFA03462.2;EFA05246.1;EFA06035.2;EEZ97803.1;EFA06999.1;EFA06447.1;EFA02571.1 KEGG: 00250+4.3.2.2 Alanine, aspartate and glutamate metabolism 1 EFA08776.1 Reactome: R-HSA-4085377 SUMOylation of SUMOylation proteins 19 EFA03584.1;EFA00581.2;EFA11447.2;EEZ97868.2;EFA09537.1;EFA11141.2;KYB29624.1;EFA00605.1;EFA05993.1;EEZ98695.2;KYB28630.1;EFA04928.2;EFA07823.1;KYB29271.1;KYB29364.1;EFA01782.2;EFA01249.2;EFA03859.1;KYB28401.1 Reactome: R-HSA-418592 ADP signalling through P2Y purinoceptor 1 3 KYB25864.1;KYB29172.1;EEZ98203.2 MetaCyc: PWY-7277 Sphingolipid biosynthesis (mammals) 1 EFA10294.2 MetaCyc: PWY-8052 2-arachidonoylglycerol biosynthesis 9 KXZ75916.1;EFA12319.2;KYB27786.1;KYB28994.1;KYB28995.1;KYB26367.1;KXZ75917.1;EFA07054.2;KYB27925.1 MetaCyc: PWY-6892 Thiazole biosynthesis I (facultative anaerobic bacteria) 1 EFA11181.1 KEGG: 00330+2.7.2.11 Arginine and proline metabolism 1 EEZ98981.2 KEGG: 00360+2.6.1.5 Phenylalanine metabolism 1 EFA03251.1 Reactome: R-HSA-5357956 TNFR1-induced NFkappaB signaling pathway 4 KYB29360.1;KYB29359.1;EFA02110.1;KYB27252.1 MetaCyc: PWY-5740 GDP-L-colitose biosynthesis 1 EFA01082.1 Reactome: R-HSA-114608 Platelet degranulation 4 KYB25398.1;EFA07880.1;EEZ98819.2;EFA07881.1 Reactome: R-HSA-8964046 VLDL clearance 6 KYB29704.1;EFA11425.1;KYB26997.1;KYB29705.1;EFA11302.1;KYB29706.1 Reactome: R-HSA-2022857 Keratan sulfate degradation 8 EEZ98597.1;EFA05960.2;EFA06863.2;EFA07069.1;EFA11380.2;EFA04898.1;EFA05959.1;EFA06836.2 Reactome: R-HSA-3134973 LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production 1 EFA02517.2 Reactome: R-HSA-879415 Advanced glycosylation endproduct receptor signaling 3 EEZ98119.2;EFA10708.1;EFA09462.2 MetaCyc: PWY-7936 Psilocybin biosynthesis 35 KYB27902.1;EFA06830.2;EFA03937.1;EFA05154.1;EFA06722.2;EFA03627.2;EFA06723.1;EFA00204.1;EFA06720.1;EFA06832.1;EFA02038.1;KYB26266.1;EFA03626.1;EFA03939.1;EFA06719.1;EFA06724.1;EFA03261.1;EFA06721.1;EFA06831.1;EFA06295.2;EFA06726.1;EFA06728.1;KYB25888.1;EFA06294.1;KYB27090.1;EEZ98805.1;EFA02416.1;EFA02417.1;EFA06293.1;EEZ97589.1;EFA07198.1;EFA07343.1;EFA06725.1;EFA06727.1;EFA03938.1 MetaCyc: PWY-6932 Selenate reduction 1 EFA13134.1 MetaCyc: PWY-7559 Glutathione degradation (DUG pathway 4 KYB26171.1;EFA08906.2;EFA08621.1;KYB26172.1 KEGG: 00240+2.7.4.14 Pyrimidine metabolism 2 EFA06562.1;EFA11131.1 KEGG: 04070+2.7.1.158 Phosphatidylinositol signaling system 2 EFA10622.1;KYB25213.1 Reactome: R-HSA-5693579 Homologous DNA Pairing and Strand Exchange 18 EFA05681.1;EFA02865.1;EFA00407.2;EFA04568.2;EFA02866.1;KYB27777.1;EEZ99558.2;EFA08981.1;KYB26388.1;EEZ97797.2;EFA09584.2;EFA08701.2;EFA10219.1;EFA11787.2;EFA13005.2;KYB28817.1;EFA04612.2;EFA07487.1 KEGG: 00053+1.8.5.1 Ascorbate and aldarate metabolism 3 EFA00963.1;EEZ99479.1;EEZ99480.1 MetaCyc: PWY-6471 Peptidoglycan biosynthesis IV (Enterococcus faecium) 3 KYB27827.1;EFA02198.2;EEZ98644.1 KEGG: 00250+1.4.1.1 Alanine, aspartate and glutamate metabolism 1 EFA03278.1 Reactome: R-HSA-203641 NOSTRIN mediated eNOS trafficking 2 EFA03682.2;KYB27571.1 MetaCyc: PWY-4381 Fatty acid biosynthesis initiation (bacteria and plants) 10 EFA05249.2;EFA05201.1;EEZ97866.2;EFA05436.2;EFA05204.2;EFA05203.2;EFA05248.1;EFA03586.1;EFA07129.2;EFA11365.1 Reactome: R-HSA-749476 RNA Polymerase III Abortive And Retractive Initiation 23 EFA11622.1;KYB26491.1;KYB28470.1;EFA07284.1;EFA03073.1;EFA07031.1;EFA05365.1;EFA02494.1;EEZ98845.2;EFA07655.1;EFA01191.1;EFA06729.1;EEZ97248.2;EFA10944.1;KYB26001.1;KYB26468.1;EEZ99545.1;EFA07935.1;EFA03150.1;EFA09807.1;EFA05896.1;EFA06650.2;EEZ99572.2 Reactome: R-HSA-211981 Xenobiotics 7 EFA02821.2;KYB25688.1;KYB25634.1;KXZ75754.1;EFA05733.1;KYB25960.1;KYB27037.1 KEGG: 00430+1.4.1.1 Taurine and hypotaurine metabolism 1 EFA03278.1 KEGG: 00520+5.3.1.9 Amino sugar and nucleotide sugar metabolism 1 EFA07687.2 Reactome: R-HSA-5620916 VxPx cargo-targeting to cilium 8 EFA06250.1;EFA04473.2;EEZ98592.2;EFA08190.1;EEZ97223.1;EFA08819.1;EEZ97195.1;EFA11086.1 MetaCyc: PWY-4702 Phytate degradation I 2 KYB25020.1;EFA12936.1 KEGG: 00230+4.3.2.2 Purine metabolism 1 EFA08776.1 MetaCyc: PWY-5041 S-adenosyl-L-methionine cycle II 3 EEZ97278.1;EFA12023.2;EFA04274.1 KEGG: 00770+2.6.1.42 Pantothenate and CoA biosynthesis 1 EEZ98004.1 Reactome: R-HSA-3214842 HDMs demethylate histones 5 KYB24563.1;EFA11284.1;EFA05479.1;EFA11272.1;EEZ99988.2 Reactome: R-HSA-3304356 SMAD2/3 Phosphorylation Motif Mutants in Cancer 3 EFA05099.1;EFA07576.2;EEZ97734.1 Reactome: R-HSA-163359 Glucagon signaling in metabolic regulation 14 KYB27523.1;KYB25556.1;EFA03628.1;EFA03954.2;KYB27619.1;KYB25554.1;EFA03625.2;KYB28863.1;EFA03629.2;KYB25555.1;KYB25552.1;EFA01439.2;EFA10712.2;KYB25553.1 Reactome: R-HSA-9610379 HCMV Late Events 28 EEZ98695.2;EFA03761.1;KYB28630.1;EFA04928.2;EFA02261.1;EFA07823.1;EFA07193.1;KYB29271.1;KYB29364.1;EFA01249.2;EFA01782.2;EFA06909.1;EFA03859.1;KYB28401.1;EEZ99668.1;EFA03584.1;EFA00581.2;EFA01867.1;EEZ97653.2;KYB24563.1;EFA11447.2;EEZ97868.2;EFA11141.2;EFA09537.1;KYB29624.1;EFA04908.1;EFA00605.1;EFA05993.1 Reactome: R-HSA-8939211 ESR-mediated signaling 2 EFA10708.1;EFA06120.1 Reactome: R-HSA-69473 G2/M DNA damage checkpoint 26 EEZ97345.1;EFA08981.1;EFA10575.1;EEZ99558.2;EFA09906.2;EFA12891.1;KYB24996.1;KYB25740.1;EFA05681.1;KYB27483.1;EEZ97760.2;KYB24563.1;KYB27777.1;EFA08916.1;EFA04568.2;EFA09711.2;EFA04934.2;EFA13005.2;EFA11787.2;KYB25791.1;EFA07487.1;EFA12420.2;EEZ97797.2;KYB26388.1;EFA02756.1;EFA09584.2 Reactome: R-HSA-77350 Beta oxidation of hexanoyl-CoA to butanoyl-CoA 1 EFA04382.1 KEGG: 00730+3.1.3.1 Thiamine metabolism 4 EFA01926.1;KYB29475.1;KYB25767.1;KYB26031.1 Reactome: R-HSA-8851680 Butyrophilin (BTN) family interactions 1 EFA09973.1 KEGG: 00410+4.2.1.17 beta-Alanine metabolism 3 EFA04382.1;EFA08151.1;EFA05073.1 MetaCyc: PWY-6558 Heparan sulfate biosynthesis (late stages) 2 EFA03870.1;EFA10381.1 Reactome: R-HSA-3214847 HATs acetylate histones 40 EFA06618.2;KYB26065.1;EFA08786.1;EFA05213.1;EFA10722.1;EEZ97863.2;EFA02321.1;EEZ99433.2;EFA00694.1;KYB27680.1;KYB28293.1;EEZ97977.1;EFA06014.1;EFA04527.1;EEZ98296.2;EFA07023.2;EFA06113.2;KYB24563.1;EFA10926.2;EFA09802.2;EFA03829.2;EFA12612.2;EFA03093.1;EFA02517.2;EFA02454.2;KYB26672.1;EFA08802.1;EFA05580.2;EFA07309.1;EFA07156.1;EFA08447.2;EFA05335.1;EFA05694.1;EFA12228.1;EFA00828.1;EFA04470.1;EFA12371.1;EFA01003.1;EFA03762.1;EFA06279.1 KEGG: 00830+1.14.14.1 Retinol metabolism 1 EFA05733.1 MetaCyc: PWY-5532 Nucleoside and nucleotide degradation (archaea) 4 EFA01001.1;EEZ98937.1;EFA03250.2;EEZ98936.1 Reactome: R-HSA-5659996 RPIA deficiency: failed conversion of R5P to RU5P 1 EFA01628.1 MetaCyc: PWY-7592 Arachidonate biosynthesis III (6-desaturase, mammals) 2 EFA03551.1;EFA05143.1 KEGG: 00010+2.7.1.1 Glycolysis / Gluconeogenesis 4 EEZ97931.1;KYB29370.1;EEZ97932.2;KYB29371.1 Reactome: R-HSA-3928662 EPHB-mediated forward signaling 8 KYB27402.1;EFA05486.1;EFA03253.1;EFA09715.1;EFA05342.1;EFA04406.2;EEZ97639.1;KYB25950.1 Reactome: R-HSA-1855191 Synthesis of IPs in the nucleus 2 KYB25213.1;EFA10622.1 KEGG: 00030+5.3.1.9 Pentose phosphate pathway 1 EFA07687.2 KEGG: 00564+1.1.1.8 Glycerophospholipid metabolism 3 EEZ98249.2;KYB29133.1;KYB29132.1 Reactome: R-HSA-165159 mTOR signalling 8 EFA07964.1;EEZ97603.1;EFA12722.1;EFA08847.1;EFA03068.1;EFA09095.1;EFA02668.2;EEZ99978.2 Reactome: R-HSA-390522 Striated Muscle Contraction 8 KYB24967.1;KYB24968.1;KYB28056.1;EEZ98444.2;KYB24970.1;KYB24969.1;EEZ97595.2;EFA02535.2 KEGG: 00750+2.6.1.52 Vitamin B6 metabolism 1 EEZ98123.1 KEGG: 00640+1.3.3.6 Propanoate metabolism 3 EFA09425.1;EFA11530.1;EFA09569.1 Reactome: R-HSA-5689880 Ub-specific processing proteases 58 EFA07110.1;KYB29359.1;EFA05912.1;EFA03093.1;KYB26545.1;KYB27959.1;KYB26972.1;EFA02422.2;EFA05370.2;EFA04284.1;KYB25309.1;EFA12812.2;EFA05833.1;EEZ99004.1;EFA06841.1;KYB24713.1;EFA09449.1;EFA09524.2;EFA08798.1;EFA05865.1;EFA04054.1;EEZ97564.1;EFA07261.2;EFA03019.1;EFA05105.1;EFA02331.1;EEZ98185.1;EFA09228.1;EFA05871.2;EFA07659.2;EFA09518.2;EFA08601.1;KYB26764.1;EFA05917.1;EFA05213.1;EFA03341.1;EEZ97876.1;KYB27556.1;EFA07762.1;EFA08664.1;EFA09116.1;KYB26971.1;EFA05327.2;EFA06200.1;EFA06741.1;EFA11079.1;EFA06519.1;EFA02110.1;EFA00536.1;EEZ99493.1;EFA08911.2;EFA02345.1;EFA13218.1;KYB27557.1;EFA02851.1;EFA07675.2;KYB29360.1;EFA08733.2 MetaCyc: PWY-5530 Sorbitol biosynthesis II 2 EFA03133.1;EFA10016.2 KEGG: 00350+3.7.1.2 Tyrosine metabolism 1 EFA06443.1 Reactome: R-HSA-8936459 RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function 11 EEZ98177.2;EFA08972.2;KYB27618.1;EFA01589.2;KYB24563.1;EFA11580.2;EFA06431.1;EFA03630.2;EFA05618.2;KYB29184.1;KYB25778.1 MetaCyc: PWY-7204 Pyridoxal 5'-phosphate salvage II (plants) 3 EFA00408.1;EFA10196.1;KYB25431.1 MetaCyc: PWY-5132 Lupulone and humulone biosynthesis 2 EFA12933.2;EFA12019.1 MetaCyc: PWY-7049 Icosapentaenoate biosynthesis II (6-desaturase, mammals) 2 EFA03551.1;EFA05143.1 KEGG: 00640+1.2.1.27 Propanoate metabolism 1 KYB27796.1 Reactome: R-HSA-2022377 Metabolism of Angiotensinogen to Angiotensins 9 EFA06546.2;KYB25027.1;EFA03659.1;EFA00163.1;EFA05307.1;EFA06070.2;EEZ97252.2;KYB25031.1;EFA05125.1 KEGG: 00280+4.2.1.17 Valine, leucine and isoleucine degradation 1 EFA04382.1 Reactome: R-HSA-140342 Apoptosis induced DNA fragmentation 1 EFA08645.1 Reactome: R-HSA-195253 Degradation of beta-catenin by the destruction complex 46 EEZ98185.1;EFA02331.1;EFA03019.1;EFA05105.1;EFA13272.2;EFA08601.1;KYB26383.1;EFA05871.2;EFA07659.2;EFA09518.2;EFA04054.1;EFA05865.1;EFA09524.2;EFA08798.1;EEZ97564.1;EFA07261.2;EFA04284.1;KYB25309.1;EFA05370.2;EFA05833.1;EEZ99004.1;KYB24713.1;KYB29359.1;EFA05912.1;EFA07110.1;KYB26545.1;EFA08911.2;EFA13218.1;EFA02345.1;EEZ99493.1;KYB29360.1;KYB27557.1;EFA05992.2;EFA02110.1;KYB26642.1;EFA06200.1;EFA08664.1;EFA11079.1;EFA06519.1;EFA06741.1;EFA02847.1;KYB26764.1;EFA03341.1;EFA09636.1;EEZ97876.1;KYB27556.1 Reactome: R-HSA-174430 Telomere C-strand synthesis initiation 7 EFA04623.2;EFA07750.2;EFA06672.2;KYB26713.1;EFA09576.1;EFA07996.1;EFA10435.1 MetaCyc: PWY-7782 Plasmalogen biosynthesis 33 EEZ97388.1;EFA07054.2;KYB27110.1;EFA05103.1;KYB26274.1;EFA05404.1;EFA05090.1;EFA08474.2;EFA07221.2;EEZ97452.1;EFA05205.1;EEZ97656.1;EFA02132.1;EFA04917.2;EFA06888.2;KYB26083.1;KYB27109.1;EFA05233.2;EFA05234.1;KYB26690.1;EEZ97257.1;EFA04973.1;EFA05235.1;EFA06889.2;EFA05564.2;KYB26367.1;EFA08449.1;EFA05024.1;EEZ99525.1;EFA04525.1;EFA08470.2;EFA04974.1;KYB27111.1 Reactome: R-HSA-4420097 VEGFA-VEGFR2 Pathway 12 EFA11394.1;KYB24949.1;EEZ97169.2;KYB27402.1;KYB26419.1;EFA06030.2;EFA11598.1;EFA04406.2;EFA13274.1;EFA10974.1;EFA03253.1;EFA03699.2 Reactome: R-HSA-9013973 TICAM1-dependent activation of IRF3/IRF7 5 KYB29360.1;EFA07517.1;EFA06854.1;KYB29359.1;EFA02110.1 Reactome: R-HSA-435368 Zinc efflux and compartmentalization by the SLC30 family 6 KYB29810.1;EFA02213.2;EFA02578.1;KYB27845.1;EFA06430.1;KYB26772.1 MetaCyc: PWY-7921 Protein O-mannosylation I (yeast) 8 KYB26307.1;EFA01829.1;EFA03006.2;KYB27854.1;KYB27853.1;EFA06224.2;EEZ97998.1;EFA04002.2 Reactome: R-HSA-68877 Mitotic Prometaphase 43 EFA06856.2;EFA07500.2;EFA13202.2;EFA07755.2;KYB26625.1;KYB25071.1;KYB25072.1;EFA06187.1;EEZ99331.1;EFA11447.2;EEZ97419.2;EFA06492.1;EFA09822.2;KYB26383.1;EFA07677.2;KYB26929.1;KYB25616.1;EEZ99348.1;EEZ99070.2;EEZ97891.1;EFA07920.2;EFA04692.2;KYB27370.1;EFA04506.2;EEZ97487.2;EFA09410.1;KYB25235.1;EFA07823.1;KYB27439.1;KYB25237.1;EFA11292.1;EFA09995.1;EFA04833.1;KYB26892.1;EFA05992.2;EFA06663.1;KYB25744.1;KYB29624.1;KYB26642.1;EEZ97229.1;EFA00171.1;KYB25236.1;EFA09537.1 Reactome: R-HSA-1489509 DAG and IP3 signaling 4 KYB29732.1;EFA07407.1;EFA11212.2;EFA07406.1 Reactome: R-HSA-5654733 Negative regulation of FGFR4 signaling 4 KYB29360.1;EFA10708.1;EFA02110.1;KYB29359.1 KEGG: 00785+2.3.1.181 Lipoic acid metabolism 3 EEZ98826.2;EFA10961.1;EFA05264.2 Reactome: R-HSA-209931 Serotonin and melatonin biosynthesis 1 EFA01002.1 MetaCyc: PWY-6672 Cis-genanyl-coa degradation 2 EFA12933.2;EFA12019.1 MetaCyc: PWY-7426 Complex N-linked glycan biosynthesis (vertebrates) 3 KYB27749.1;EFA02784.1;EFA12804.1 Reactome: R-HSA-5687128 MAPK6/MAPK4 signaling 49 EFA04626.2;EFA06519.1;EFA11079.1;EFA06741.1;EFA06200.1;EFA08664.1;KYB25999.1;KYB27556.1;EEZ97876.1;EFA11590.1;EFA03341.1;KYB26764.1;EFA09995.1;KYB29360.1;KYB27557.1;EFA13218.1;EFA02345.1;EFA08911.2;EEZ99493.1;EFA02110.1;KYB24713.1;EFA05833.1;EEZ99004.1;EFA04284.1;KYB25309.1;EFA05370.2;KYB26545.1;KYB26000.1;EFA05912.1;KYB29359.1;EFA07110.1;EFA08601.1;EFA09518.2;EFA05871.2;EFA07659.2;EFA08972.2;EFA09197.2;EEZ98185.1;EFA02331.1;EFA05105.1;EFA03019.1;EFA07261.2;EEZ97564.1;KYB25778.1;EFA05865.1;EFA04054.1;EFA08798.1;EFA03253.1;EFA09524.2 Reactome: R-HSA-193648 NRAGE signals death through JNK 15 KYB28884.1;KYB28879.1;KYB27184.1;KYB24949.1;KYB28883.1;EEZ97169.2;EFA06518.2;EFA06829.2;KXZ75734.1;EFA00242.2;EFA11099.2;KXZ75736.1;KYB28880.1;KYB27183.1;KXZ75737.1 MetaCyc: PWY-6383 Mono-trans, poly-cis decaprenyl phosphate biosynthesis 1 EFA07280.1 Reactome: R-HSA-9656255 Defective OGG1 Substrate Binding 1 EFA06198.1 Reactome: R-HSA-9635465 Suppression of apoptosis 1 EFA10708.1 Reactome: R-HSA-9627069 Regulation of the apoptosome activity 7 EEZ98372.1;KYB27349.1;EFA07698.1;EFA08214.1;KYB27348.1;EFA01361.1;EFA10708.1 MetaCyc: PWY-7214 Baicalein degradation (hydrogen peroxide detoxification) 1 EFA01243.1 KEGG: 00760+2.4.2.1 Nicotinate and nicotinamide metabolism 2 EFA01001.1;EFA03250.2 KEGG: 00062+4.2.1.17+1.1.1.211 Fatty acid elongation 1 EFA04382.1 MetaCyc: PWY-6367 D-myo-inositol-5-phosphate metabolism 8 KYB27925.1;KXZ75917.1;KYB28995.1;KXZ75916.1;EFA12319.2;KYB28994.1;KYB27786.1;EFA01248.1 Reactome: R-HSA-381033 ATF6 (ATF6-alpha) activates chaperones 4 EFA00011.2;KYB28740.1;EEZ98063.1;EEZ98819.2 KEGG: 00130+1.17.4.4 Ubiquinone and other terpenoid-quinone biosynthesis 1 KYB26129.1 Reactome: R-HSA-432040 Vasopressin regulates renal water homeostasis via Aquaporins 19 KYB25553.1;KYB28779.1;EFA10712.2;EFA01439.2;KYB28863.1;KYB25554.1;EFA03628.1;EFA03954.2;KYB27523.1;EEZ99469.1;KYB26602.1;EFA06381.2;KYB25552.1;KYB25555.1;KYB25864.1;EFA03629.2;EFA03625.2;KYB27619.1;KYB25556.1 Reactome: R-HSA-198323 AKT phosphorylates targets in the cytosol 5 KYB27979.1;EFA09042.2;EEZ97603.1;KYB27978.1;EFA02105.1 Reactome: R-HSA-182971 EGFR downregulation 6 EFA11193.1;EFA09116.1;EFA03253.1;KYB29359.1;EFA02110.1;KYB29360.1 MetaCyc: PWY-6642 (R)-cysteate degradation 3 EFA03109.1;KYB27212.1;EFA04122.1 KEGG: 05165+2.7.1.153 Human papillomavirus infection 1 EFA09848.2 MetaCyc: PWY-7238 Sucrose biosynthesis II 5 EFA07687.2;EFA06874.2;EFA10130.2;KYB25482.1;EFA02541.1 Reactome: R-HSA-76066 RNA Polymerase III Transcription Initiation From Type 2 Promoter 20 EFA02494.1;EFA07655.1;EFA01191.1;EFA07284.1;EFA03073.1;EFA07031.1;EFA11622.1;KYB26491.1;KYB28470.1;EFA05896.1;EFA06650.2;EEZ99572.2;EFA09807.1;KYB26001.1;KYB26468.1;EEZ99545.1;EFA07935.1;EFA03150.1;EFA06729.1;EEZ97248.2 Reactome: R-HSA-2022854 Keratan sulfate biosynthesis 4 EFA12917.2;EFA08717.1;KXZ75832.1;EFA09998.1 Reactome: R-HSA-2029482 Regulation of actin dynamics for phagocytic cup formation 11 KYB24949.1;EFA05486.1;EEZ97169.2;KYB25950.1;EFA10974.1;EFA09668.1;EFA05342.1;EFA13274.1;EFA03253.1;EFA10708.1;EFA03329.2 Reactome: R-HSA-5686938 Regulation of TLR by endogenous ligand 6 EFA11425.1;KYB26997.1;KYB29704.1;EFA11302.1;KYB29706.1;KYB29705.1 MetaCyc: PWY-7761 NAD salvage pathway II (PNC IV cycle) 2 EFA01802.1;EFA10127.2 Reactome: R-HSA-8951664 Neddylation 94 EFA00463.1;EFA03803.1;EEZ98265.1;EFA02345.1;EFA11877.1;EEZ97976.1;KYB29360.1;EFA00464.1;KYB27557.1;EFA00552.1;KYB26764.1;EFA05359.1;KYB25639.1;EFA03060.1;EFA06200.1;KYB26881.1;EFA08664.1;KYB25844.1;EFA06519.1;KYB24960.1;EFA04054.1;EFA05865.1;EFA08798.1;EFA09688.1;EFA09524.2;EFA07261.2;EFA09306.2;EFA01483.2;EFA06626.2;KYB25845.1;EEZ98589.1;EFA03019.1;EFA08217.1;KYB29653.1;EFA07659.2;EFA05871.2;EFA05912.1;KYB26545.1;EFA02347.1;EFA04132.1;KYB25309.1;EFA11744.1;EFA05370.2;EFA04028.1;EEZ99944.2;EFA03809.2;EFA05833.1;EFA02110.1;EFA09966.2;EFA03472.1;EFA13218.1;EFA04065.1;EFA08911.2;EEZ99493.1;EFA07468.1;KYB27099.1;EFA02847.1;EFA00073.1;KYB25840.1;EFA03341.1;EFA07009.1;EFA08704.1;EFA07350.1;KYB29092.1;EEZ97876.1;EFA08917.1;KYB27556.1;EEZ99274.1;EFA02056.1;EFA11079.1;EFA02057.1;EFA06741.1;EFA08119.1;EEZ99059.1;KYB25846.1;EFA12878.2;EEZ97564.1;EEZ98185.1;EFA02331.1;EFA05105.1;KYB26394.1;EFA08601.1;EFA09518.2;KYB29359.1;EFA12663.1;EFA07110.1;KYB28650.1;EFA07112.2;EFA04284.1;EFA01469.1;EFA10040.1;KYB24713.1;EEZ99004.1;KYB28722.1 KEGG: 00640+2.6.1.19 Propanoate metabolism 2 KYB25521.1;KYB25522.1 Reactome: R-HSA-880009 Interconversion of 2-oxoglutarate and 2-hydroxyglutarate 1 EFA10918.1 Reactome: R-HSA-445989 TAK1 activates NFkB by phosphorylation and activation of IKKs complex 4 EFA02110.1;KYB29359.1;EFA02851.1;KYB29360.1 Reactome: R-HSA-983712 Ion channel transport 23 EEZ98813.2;KYB29409.1;EFA02908.1;EEZ97227.1;KYB29413.1;EFA06700.2;EFA10717.1;EFA02242.2;EFA05894.1;EEZ99071.2;KYB29410.1;EEZ98406.2;KYB29412.1;EFA02241.1;KYB28989.1;EFA06225.1;EFA03371.1;EFA01142.2;EFA02476.1;EFA08618.1;KYB29411.1;EFA11012.1;EEZ99208.1 MetaCyc: PWY-7524 Mevalonate pathway III (archaea) 4 EFA07280.1;EFA06304.1;EFA06636.1;KYB27676.1 MetaCyc: PWYG-321 8 EEZ97866.2;EFA05201.1;EFA05249.2;EFA03463.2;EFA05248.1;EFA11365.1;EFA05204.2;EFA05203.2 KEGG: 00260+2.3.1.37 Glycine, serine and threonine metabolism 1 EFA03355.2 Reactome: R-HSA-6787450 tRNA modification in the mitochondrion 6 KYB29821.1;EEZ98974.2;EFA01836.2;EFA09866.2;EEZ99485.2;EFA07642.2 KEGG: 00650+2.6.1.19 Butanoate metabolism 2 KYB25522.1;KYB25521.1 KEGG: 00220+3.5.1.14 Arginine biosynthesis 2 KYB25257.1;EFA10313.1 Reactome: R-HSA-6799198 Complex I biogenesis 44 EFA01338.1;EFA04664.1;EFA05672.1;KYB26384.1;EFA07408.1;EEZ98642.1;KYB25739.1;EEZ97742.1;EFA10821.1;EFA02878.1;EFA03518.2;EFA05697.1;EEZ99191.1;EFA07503.1;EFA10794.1;EFA10819.1;EFA04600.1;EFA07439.1;EFA04681.1;EFA01357.1;EFA10667.1;EFA07540.1;EFA01282.1;EFA09221.1;EFA00688.1;EFA04705.1;EFA05745.1;EFA05568.1;EFA10746.1;EFA04623.2;EFA09231.1;EFA07356.1;EEZ98853.1;KYB25738.1;KYB27169.1;EFA01736.1;EFA12181.1;EFA09217.1;EEZ97472.1;EFA04686.2;KYB28574.1;EEZ97756.1;EEZ97690.1;EEZ98766.1 KEGG: 00730+3.6.1.15 Thiamine metabolism 1 KYB29374.1 Reactome: R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation 44 EFA08981.1;EFA04061.1;EEZ99558.2;KYB27483.1;EFA00919.1;EFA02004.1;KYB29038.1;EFA08916.1;KYB27777.1;EFA09906.2;EEZ97886.2;EFA05681.1;EEZ99738.1;KYB25740.1;KYB25791.1;EEZ97852.2;EFA03093.1;EFA10720.1;KYB29359.1;EFA13005.2;EFA11787.2;EFA02756.1;EFA07410.1;EFA00031.1;KYB29037.1;KYB26388.1;EFA07851.1;EFA02110.1;EEZ97345.1;EFA04568.2;EFA12891.1;KYB29360.1;EFA07487.1;EFA00911.1;EFA12420.2;EFA09711.2;EFA04934.2;EFA00476.1;EFA09584.2;EFA11878.1;EFA10605.2;EFA02321.1;EFA05523.2;EEZ97797.2 Reactome: R-HSA-196757 Metabolism of folate and pterines 7 EEZ98122.1;EFA09131.1;EFA07671.2;EFA07236.1;EFA07809.2;EFA07237.1;EFA05437.1 KEGG: 00720+4.2.1.3 Carbon fixation pathways in prokaryotes 2 EFA02996.1;EFA08121.1 KEGG: 00240+2.7.1.48 Pyrimidine metabolism 3 EFA11381.2;EEZ97798.2;KYB28983.1 Reactome: R-HSA-422085 Synthesis, secretion, and deacylation of Ghrelin 8 EFA03199.1;EFA02397.1;EFA06763.1;EFA07146.1;EFA04156.1;KYB26709.1;EEZ97812.1;EEZ99262.2 MetaCyc: PWY-6969 TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase) 15 EFA03144.1;EFA03750.1;EFA10709.2;EFA07160.1;EFA05014.1;EFA09226.1;EFA04972.1;EFA04683.1;EFA11129.1;EFA02482.1;EFA11202.1;EFA10595.2;EFA02829.1;EFA09539.1;EFA04299.1 KEGG: 00073+1.2.1.84 Cutin, suberine and wax biosynthesis 25 EFA08474.2;EFA06889.2;EFA05090.1;KYB26274.1;EFA05103.1;EFA05404.1;EFA05235.1;EFA04973.1;EEZ97388.1;KYB26690.1;EFA05234.1;KYB26083.1;EFA04974.1;KYB27109.1;EFA05233.2;EFA08470.2;EFA06888.2;EFA04917.2;EEZ99525.1;EFA05205.1;EEZ97452.1;EFA08449.1;EFA05024.1;EFA05564.2;EFA07221.2 KEGG: 00760+3.1.3.5 Nicotinate and nicotinamide metabolism 1 EFA01792.1 Reactome: R-HSA-419812 Calcitonin-like ligand receptors 1 EFA04592.1 Reactome: R-HSA-381340 Transcriptional regulation of white adipocyte differentiation 32 EFA00809.1;EFA00806.2;EFA02017.1;EFA08558.1;EFA03598.1;KYB26838.1;EEZ97247.1;EFA02633.1;EFA10996.1;KYB27096.1;EEZ98716.2;EFA08543.1;EFA02517.2;EFA01959.1;EFA01136.1;EFA04179.1;EFA00114.1;EEZ97239.1;EFA06894.2;KYB25781.1;EFA04844.1;EFA00473.1;KYB28595.1;EFA06850.2;EFA03597.1;EFA09949.2;EFA03097.1;EFA01132.1;EFA07012.2;EFA00475.1;KYB28596.1;EFA09832.1 Reactome: R-HSA-1483101 Synthesis of PS 1 EFA04520.1 MetaCyc: PWY-735 Jasmonic acid biosynthesis 3 EFA09569.1;EFA09425.1;EFA11530.1 Reactome: R-HSA-391160 Signal regulatory protein family interactions 3 EFA12064.1;EFA06030.2;KYB26419.1 Reactome: R-HSA-75955 RNA Polymerase II Transcription Elongation 35 EFA12997.1;KYB29064.1;EEZ99586.2;EFA10288.1;KYB28470.1;EFA00018.1;EFA07031.1;EFA00606.1;EFA00603.1;EEZ97398.2;EFA00397.1;EFA07995.2;KYB25378.1;EFA05226.1;KYB25152.1;EFA03150.1;EFA03550.1;EFA10605.2;KYB26001.1;EFA07302.1;EFA03559.1;EFA07055.2;EFA04061.1;EFA02310.1;EFA06469.1;EFA00328.1;EFA07148.1;KYB25207.1;EFA05446.1;EFA05896.1;EFA05606.1;EEZ97432.2;EFA08590.1;EEZ97363.1;EFA06560.1 Reactome: R-HSA-1296061 HCN channels 2 EFA08934.1;KYB26551.1 KEGG: 00780+1.1.1.100+4.2.1.59+2.3.1.41 Biotin metabolism 7 EFA05248.1;EFA11365.1;EEZ97866.2;EFA05204.2;EFA05201.1;EFA05249.2;EFA05203.2 Reactome: R-HSA-2426168 Activation of gene expression by SREBF (SREBP) 22 EFA08558.1;EFA06636.1;EEZ97866.2;KYB26838.1;EFA05249.2;EFA05201.1;EFA05248.1;EFA09953.1;EFA00806.2;EFA01850.1;EFA05203.2;EFA00378.2;EFA05436.2;KYB28596.1;EFA11365.1;KYB29328.1;EFA05256.2;KYB27676.1;EFA02059.2;KYB28595.1;EFA10996.1;EFA05204.2 MetaCyc: PWY-5871 Ubiquinol-9 biosynthesis (eukaryotic) 3 EFA04400.1;KYB26214.1;KYB26307.1 MetaCyc: PWY-6361 1D-myo-inositol hexakisphosphate biosynthesis I (from Ins(1,4,5)P3) 2 KYB25213.1;EFA10622.1 KEGG: 00650+4.2.1.17+1.1.1.35 Butanoate metabolism 3 EFA08151.1;EFA05073.1;EFA04382.1 MetaCyc: PWY-7115 C4 photosynthetic carbon assimilation cycle, NAD-ME type 10 KYB27212.1;EFA11790.2;EFA04508.1;EFA03109.1;KYB29101.1;EEZ98484.1;EFA04122.1;EFA00432.1;EFA04972.1;EFA02482.1 Reactome: R-HSA-9604323 Negative regulation of NOTCH4 signaling 39 EFA08664.1;EFA06200.1;EFA06741.1;EFA11079.1;EFA06519.1;EFA03341.1;EFA02847.1;KYB27556.1;EEZ97876.1;EEZ99493.1;EFA08911.2;EFA13218.1;EFA02345.1;KYB27557.1;KYB29360.1;EFA02110.1;EFA05370.2;EFA04284.1;KYB25309.1;EEZ99004.1;EFA05833.1;KYB24713.1;EFA07110.1;EFA05912.1;KYB29359.1;KYB26545.1;EFA03019.1;EFA05105.1;EEZ98185.1;EFA02331.1;EFA05871.2;EFA07659.2;EFA09518.2;EFA08601.1;EFA09524.2;EFA08798.1;EFA05865.1;EFA04054.1;EEZ97564.1 KEGG: 00051+5.3.1.6 Fructose and mannose metabolism 1 EFA01628.1 Reactome: R-HSA-425561 Sodium/Calcium exchangers 13 KYB25176.1;KYB26194.1;EFA03343.2;KYB26196.1;KYB26193.1;EFA07201.2;KYB26195.1;EFA03342.1;EFA04235.2;EFA09437.2;KYB26197.1;EFA06448.1;KYB27277.1 Reactome: R-HSA-3642279 TGFBR2 MSI Frameshift Mutants in Cancer 2 EEZ97734.1;EFA07576.2 Reactome: R-HSA-2871837 FCERI mediated NF-kB activation 44 EFA03341.1;KYB26764.1;EFA02847.1;KYB27556.1;EEZ97876.1;EFA08664.1;EEZ99274.1;EFA06200.1;EFA06741.1;EFA06519.1;EFA11079.1;EFA02110.1;EEZ99493.1;EFA13218.1;EFA02345.1;EFA08911.2;KYB27557.1;KYB29360.1;EFA02851.1;EFA07110.1;KYB29359.1;EFA05912.1;KYB26545.1;EFA05370.2;EFA04284.1;KYB25309.1;KYB24713.1;EEZ99004.1;EFA05833.1;EFA08798.1;EFA09524.2;EFA05865.1;EFA04054.1;EFA07261.2;EEZ97564.1;EFA05105.1;EFA03019.1;EEZ98185.1;EFA00152.1;EFA02331.1;EFA09518.2;EFA07659.2;EFA05871.2;EFA08601.1 KEGG: 00130+2.6.1.5 Ubiquinone and other terpenoid-quinone biosynthesis 1 EFA03251.1 KEGG: 00720+6.3.4.3 Carbon fixation pathways in prokaryotes 2 EFA07236.1;EFA07237.1 Reactome: R-HSA-6802952 Signaling by BRAF and RAF fusions 15 KYB29089.1;KYB29090.1;EEZ99237.2;EFA06298.2;EFA00120.1;KYB26661.1;EFA09480.2;EFA10708.1;KYB26663.1;KYB25937.1;KYB28360.1;KYB25457.1;EFA08276.1;KYB26173.1;EEZ99807.2 MetaCyc: PWY-6385 Peptidoglycan biosynthesis III (mycobacteria) 1 EEZ98644.1 MetaCyc: PWY-8055 Palmitoyl ethanolamide biosynthesis 10 EFA04525.1;KYB27111.1;EFA06119.2;KYB26367.1;EFA07054.2;EEZ97257.1;EEZ97656.1;KYB27110.1;EFA09975.1;EFA02132.1 Reactome: R-HSA-8948747 Regulation of PTEN localization 4 EFA02110.1;KYB29359.1;EFA07762.1;KYB29360.1 KEGG: 00511+3.2.1.45 Other glycan degradation 1 EFA07388.1 Reactome: R-HSA-2408522 Selenoamino acid metabolism 11 EFA01911.1;EFA09968.1;KYB25520.1;KYB26719.1;EFA06771.1;EFA02651.1;EFA00049.1;EFA11240.1;EFA04272.1;KYB26720.1;EEZ99471.1 KEGG: 00562+2.7.1.153 Inositol phosphate metabolism 1 EFA09848.2 KEGG: 00270+2.1.1.37 Cysteine and methionine metabolism 2 KYB29654.1;EFA09160.1 Reactome: R-HSA-71737 Pyrophosphate hydrolysis 1 EEZ98942.2 Reactome: R-HSA-380095 Tachykinin receptors bind tachykinins 3 KYB25112.1;EEZ99366.2;EEZ97719.2 KEGG: 00511+3.2.1.23 Other glycan degradation 9 EFA07842.1;EFA04110.1;EFA06933.2;EEZ97806.1;EFA07843.2;EFA07841.1;EEZ99315.1;EEZ99316.1;KYB26528.1 KEGG: 00790+4.1.99.22 Folate biosynthesis 1 EEZ98181.1 Reactome: R-HSA-380259 Loss of Nlp from mitotic centrosomes 15 EEZ97959.1;EFA06332.2;EFA02136.2;EFA07920.2;EFA03783.1;KYB25597.1;KYB26566.1;EFA10255.2;EFA05098.1;KYB28459.1;EEZ98528.1;KYB27666.1;KYB28460.1;EFA09381.2;KYB25744.1 Reactome: R-HSA-420092 Glucagon-type ligand receptors 1 KYB25864.1 Reactome: R-HSA-110362 POLB-Dependent Long Patch Base Excision Repair 8 KYB27720.1;KYB27721.1;EFA12889.2;EFA06383.1;KYB26857.1;EFA00829.2;EEZ98465.1;KXZ75899.1 MetaCyc: PWY-7337 10-cis-heptadecenoyl-CoA degradation (yeast) 3 EFA09425.1;EFA11530.1;EFA09569.1 Reactome: R-HSA-432722 Golgi Associated Vesicle Biogenesis 5 EFA06046.2;EFA10392.1;EEZ97861.1;EFA06233.1;EFA11080.2 KEGG: 00051+2.7.1.1 Fructose and mannose metabolism 4 EEZ97932.2;KYB29370.1;EEZ97931.1;KYB29371.1 Reactome: R-HSA-176974 Unwinding of DNA 14 EFA03620.1;EFA06648.2;EEZ97575.1;EFA06449.1;KYB26668.1;EFA12251.1;EFA07113.1;EFA05648.1;EEZ97375.1;EFA10560.2;EEZ97925.1;EFA03409.1;EFA13575.1;EFA12381.1 MetaCyc: PWY-3661-1 Glycine betaine degradation II (mammalian) 1 EFA09131.1 Reactome: R-HSA-190861 Gap junction assembly 12 EEZ99348.1;KYB26625.1;KYB26929.1;EFA06663.1;EEZ99070.2;EEZ99331.1;EFA06187.1;EEZ97229.1;EFA11292.1;EEZ97891.1;EFA04833.1;EFA09822.2 KEGG: 00680+2.6.1.52 Methane metabolism 1 EEZ98123.1 MetaCyc: PWY-6963 Ammonia assimilation cycle I 3 EEZ97848.1;EFA03092.1;EEZ99821.1 KEGG: 00332+1.2.1.41 Carbapenem biosynthesis 1 EEZ98981.2 Reactome: R-HSA-9014325 TICAM1,TRAF6-dependent induction of TAK1 complex 4 EFA02110.1;KYB29359.1;EFA02851.1;KYB29360.1 KEGG: 00900+2.2.1.7 Terpenoid backbone biosynthesis 1 EFA11181.1 KEGG: 00480+1.11.1.15 Glutathione metabolism 7 EEZ99359.1;EFA05664.1;EEZ99271.1;EFA10733.1;EFA11546.1;EFA04630.1;EFA02019.1 Reactome: R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit 91 EFA10462.1;EFA10123.1;KYB25876.1;EFA03236.1;EFA11360.1;EFA02257.1;EFA01765.1;EFA10183.1;EEZ97360.2;EFA05803.1;EFA10173.2;KYB29360.1;EFA02592.1;EFA09345.2;EFA03441.1;EFA03478.1;EEZ98503.1;KYB27741.1;EEZ98858.1;EFA02515.1;EFA05373.1;EEZ99023.1;EFA04159.1;KYB27801.1;EFA11293.1;KYB26424.1;KYB29621.1;EFA09970.1;EEZ99635.1;EFA04093.1;EFA09390.1;EFA07317.1;EFA08069.1;EEZ98852.1;EFA03166.1;EFA10969.1;KYB27481.1;EFA01611.1;EEZ97645.1;EFA12204.1;EFA02554.1;EFA10249.1;EFA01051.1;EFA00163.1;EFA05471.1;EFA04120.1;EFA00209.1;EFA01805.1;EFA05867.1;EFA07030.1;EFA11837.1;EFA02110.1;EFA00505.1;EFA08849.1;EFA08168.1;EFA10201.2;EFA06382.1;EEZ97313.1;EEZ97412.1;EFA00935.2;EFA08054.1;EFA06707.1;EFA02992.1;EFA03533.1;EFA08624.1;EFA06341.1;EFA09212.1;KYB27567.1;EFA06574.1;EEZ99942.1;EFA01731.1;EEZ98728.1;EFA08366.2;EFA09067.1;EFA13254.1;EEZ99099.1;EEZ97224.1;EFA03346.1;EFA02268.1;EFA04946.1;EFA01104.1;EFA07141.1;EFA04453.1;EFA02145.1;KYB29359.1;EFA06534.1;EFA05170.2;EFA07164.1;EEZ97379.1;EFA01900.1;EFA13692.2 KEGG: 04070+3.1.3.36 Phosphatidylinositol signaling system 2 EFA09929.2;EFA11114.1 Reactome: R-HSA-8847993 ERBB2 Activates PTK6 Signaling 1 EFA01355.2 MetaCyc: PWY-7385 1,3-propanediol biosynthesis (engineered) 7 KYB29132.1;EFA07687.2;EFA08228.2;EEZ98249.2;KYB29133.1;EFA04932.1;KYB26002.1 Reactome: R-HSA-376172 DSCAM interactions 1 EFA11598.1 KEGG: 04150+2.7.11.24 mTOR signaling pathway 5 EFA10708.1;EFA06559.2;EFA09273.1;EFA10425.2;EFA11598.1 Reactome: R-HSA-3000171 Non-integrin membrane-ECM interactions 18 KYB27641.1;KYB27445.1;EFA04092.2;KYB28643.1;EFA01213.2;KYB25044.1;KYB27642.1;EFA01328.2;EFA04469.2;KYB28295.1;KYB27637.1;KYB27188.1;KYB27643.1;KYB28537.1;EEZ99723.1;KYB27644.1;EFA06291.1;EFA04342.1 MetaCyc: PWY-8041 Ultra-long-chain fatty acid biosynthesis 21 EFA03551.1;KYB25453.1;EFA03752.1;EFA00083.2;EFA09483.1;KYB29211.1;EFA05977.1;EFA00084.1;EFA10641.2;EEZ97311.1;EFA10642.1;EFA05474.1;EFA09795.1;KYB29213.1;KYB25455.1;EFA05473.2;KYB25454.1;EFA09796.1;KYB25229.1;EFA10643.2;EFA05143.1 Reactome: R-HSA-1474151 Tetrahydrobiopterin (BH4) synthesis, recycling, salvage and regulation 6 EFA03064.1;EFA05403.1;EFA07671.2;EFA03065.1;EFA08713.1;EFA13034.1 MetaCyc: PWY-6536 4-aminobutanoate degradation III 2 KYB25522.1;KYB25521.1 Reactome: R-HSA-9029569 NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux 10 EFA04626.2;EFA08972.2;EFA05391.1;EFA09197.2;EFA07303.1;KYB25999.1;EFA09849.1;KYB26000.1;KYB25778.1;EFA11590.1 KEGG: 00052+2.7.7.9 Galactose metabolism 1 EFA06874.2 Reactome: R-HSA-4570571 Defective RFT1 causes RFT1-CDG (CDG-1n) 1 EFA07754.1 Reactome: R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript 44 EFA00581.2;EFA11869.1;EFA03584.1;EEZ97868.2;EEZ98316.2;EFA08132.1;KYB29624.1;EFA11141.2;EFA09537.1;EFA00605.1;EFA11531.2;EFA01125.1;KYB28630.1;EFA09827.1;EFA01592.2;EFA04928.2;EFA05604.1;EFA07823.1;KYB29271.1;EEZ97980.2;EFA07541.2;KYB28401.1;EFA01249.2;KYB26337.1;EFA12271.1;EFA11447.2;EFA01773.2;EFA09426.1;EEZ98144.2;EEZ98143.1;KYB29603.1;EFA07988.1;KYB25942.1;EFA05993.1;EFA08780.1;EEZ98695.2;EFA02444.1;EFA10607.2;EFA07957.1;KYB29364.1;EFA08116.2;EFA03859.1;EFA06063.1;EFA01782.2 Reactome: R-HSA-1482925 Acyl chain remodelling of PG 8 EFA05083.2;KYB27220.1;EFA03430.2;KYB27219.1;EFA08691.1;EEZ98801.1;KYB27221.1;EEZ99784.2 KEGG: 00511+3.2.1.25 Other glycan degradation 3 KYB26528.1;EFA06933.2;KYB26527.1 KEGG: 00520+5.1.3.2 Amino sugar and nucleotide sugar metabolism 3 EFA06422.2;KYB26631.1;EFA06670.2 MetaCyc: PWY-5138 Fatty acid beta-oxidation IV (unsaturated, even number) 3 EFA04382.1;EFA05073.1;EFA08151.1 KEGG: 00062+4.2.1.17+1.1.1.35 Fatty acid elongation 3 EFA05073.1;EFA08151.1;EFA04382.1 KEGG: 00230+3.6.1.6 Purine metabolism 1 EFA07795.2 MetaCyc: PWY-1861 Formaldehyde assimilation II (assimilatory RuMP Cycle) 6 KYB26002.1;EFA04932.1;EFA01628.1;EFA08228.2;EEZ97576.1;EEZ98187.1 Reactome: R-HSA-450321 JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 5 EFA02851.1;KYB29360.1;EFA09273.1;KYB29359.1;EFA02110.1 Reactome: R-HSA-163765 ChREBP activates metabolic gene expression 10 EFA05203.2;EFA05204.2;EFA11365.1;EFA02059.2;EFA05248.1;EFA05249.2;EFA05201.1;EEZ97866.2;EFA05436.2;EFA05014.1 KEGG: 00520+2.6.1.16 Amino sugar and nucleotide sugar metabolism 2 EEZ99805.2;KYB28361.1 MetaCyc: PWY-6842 Glutathione-mediated detoxification II 8 EFA00963.1;EEZ99479.1;KYB26172.1;EFA08906.2;KYB26171.1;EFA08621.1;EFA08560.1;EEZ99480.1 Reactome: R-HSA-9010553 Regulation of expression of SLITs and ROBOs 122 EFA01805.1;EFA05867.1;EFA07030.1;EEZ99493.1;EFA13218.1;EFA08911.2;EFA00505.1;EFA08849.1;EFA08168.1;EFA11837.1;EFA02110.1;EFA06741.1;EFA08054.1;EFA11079.1;EFA10201.2;EEZ97313.1;EFA06382.1;EEZ97412.1;EFA00935.2;KYB27556.1;EEZ97876.1;EFA02992.1;EFA03533.1;EFA06291.1;KYB26337.1;EFA03341.1;EFA09518.2;EFA00043.2;KYB27567.1;EFA06574.1;EFA08601.1;EFA08624.1;EFA05105.1;EFA06341.1;EFA09212.1;EEZ98185.1;EFA02331.1;EEZ98404.1;EEZ98143.1;EFA13254.1;EEZ97564.1;EFA01731.1;EEZ98728.1;EFA09067.1;EFA04946.1;KYB24713.1;EEZ99004.1;EFA07141.1;EEZ99099.1;EFA04284.1;EFA03346.1;EFA02268.1;EFA05170.2;EFA08116.2;EFA06534.1;EEZ97379.1;EFA02145.1;EFA04453.1;EFA07110.1;KYB29359.1;KYB27557.1;EFA01765.1;EFA11869.1;EEZ97360.2;EFA10183.1;EFA05803.1;KYB29360.1;EFA02592.1;EFA10173.2;EFA10462.1;EEZ98876.1;EFA02345.1;EFA03236.1;EFA11360.1;EFA02257.1;EEZ98503.1;KYB27741.1;EEZ98858.1;EFA09345.2;EFA03441.1;EFA03478.1;EFA06519.1;EFA08664.1;EFA05373.1;EFA06200.1;EEZ99023.1;KYB29621.1;EFA09970.1;KYB26764.1;EFA04159.1;KYB27801.1;EFA07541.2;KYB26424.1;EFA11293.1;EFA12271.1;EFA07317.1;EFA07659.2;EFA05871.2;EFA03166.1;EEZ98852.1;EFA10969.1;EFA03019.1;EFA09390.1;EEZ98144.2;EFA02554.1;EFA07261.2;EFA01051.1;EFA08798.1;KYB27481.1;EFA09524.2;EEZ97645.1;EFA12204.1;EFA05865.1;EFA04054.1;EFA05833.1;EFA05370.2;EFA00163.1;KYB25309.1;EFA05471.1;EFA04120.1;KYB26545.1;EFA05912.1 Reactome: R-HSA-5619107 Defective TPR may confer susceptibility towards thyroid papillary carcinoma (TPC) 19 EFA09537.1;EFA11141.2;KYB29624.1;EFA00605.1;EFA05993.1;EFA03584.1;EFA00581.2;EEZ97868.2;EFA11447.2;EFA07823.1;KYB29271.1;KYB29364.1;EFA01782.2;EFA01249.2;EFA03859.1;KYB28401.1;EEZ98695.2;KYB28630.1;EFA04928.2 Reactome: R-HSA-2979096 NOTCH2 Activation and Transmission of Signal to the Nucleus 12 EFA05049.2;EFA04103.1;KYB29359.1;EFA07122.1;EFA02110.1;KYB27078.1;EFA10954.1;KYB26560.1;KYB27259.1;EFA07178.2;EFA03528.1;KYB29360.1 KEGG: 00062+2.3.1.199 Fatty acid elongation 19 EFA09483.1;EFA03752.1;EFA00083.2;KYB25453.1;EFA05977.1;EFA00084.1;KYB29211.1;KYB29213.1;EFA09795.1;KYB25455.1;EFA05474.1;EFA10642.1;EFA10641.2;EEZ97311.1;EFA10643.2;KYB25229.1;EFA05473.2;EFA09796.1;KYB25454.1 Reactome: R-HSA-418217 G beta:gamma signalling through PLC beta 2 KYB27786.1;KYB25864.1 Reactome: R-HSA-9630221 Defective NTHL1 substrate processing 1 EFA08192.2 MetaCyc: PWY-5663 Erythro-tetrahydrobiopterin biosynthesis I 2 EFA05403.1;EFA13034.1 MetaCyc: PWY-6124 Inosine-5'-phosphate biosynthesis II 3 EFA08776.1;EEZ97680.1;EEZ98830.1 Reactome: R-HSA-8955332 Carboxyterminal post-translational modifications of tubulin 23 EFA07282.1;EFA04833.1;EFA09822.2;EFA02415.1;EFA11292.1;EFA11053.2;EEZ97229.1;KYB27442.1;EEZ99070.2;EEZ98564.1;EFA02053.1;KYB26929.1;EFA06663.1;EEZ99348.1;EFA09309.2;EFA06325.1;EEZ97891.1;KYB27443.1;EFA04346.2;EFA06187.1;EEZ99331.1;EFA07333.2;KYB26625.1 Reactome: R-HSA-4719377 Defective DPM2 causes DPM2-CDG (CDG-1u) 2 EFA04846.1;EFA06224.2 KEGG: 05163+2.7.11.1 Human cytomegalovirus infection 55 EFA05002.2;KYB27919.1;EFA06330.1;KYB26173.1;EFA00476.1;EFA00805.1;EFA00691.2;EFA11391.2;KYB28438.1;KYB28374.1;EFA08613.1;KYB25762.1;KYB27402.1;EFA13584.2;EEZ98563.1;EFA07902.1;EFA04100.2;EFA02123.1;EFA11184.1;KYB28836.1;KYB28439.1;EEZ99162.2;KYB29263.1;EFA11019.1;EEZ99828.2;KYB27978.1;KYB28837.1;EFA07410.1;KYB28437.1;KYB27138.1;EFA05720.1;EFA03058.1;EFA02105.1;EFA07964.1;EEZ98574.2;KYB29873.1;EFA11787.2;EEZ97987.1;EFA02342.2;EFA10720.1;EFA04406.2;KYB25791.1;EFA07752.1;EFA00769.1;EFA11394.1;EFA08636.2;EFA08276.1;EFA00152.1;EFA10912.2;EFA10048.1;KYB28377.1;KYB28375.1;EFA01876.2;KYB27979.1;KYB28376.1 MetaCyc: PWY-7417 Phospholipid remodeling (phosphatidate, yeast) 29 EFA11812.1;EFA04525.1;KYB27219.1;KYB27111.1;KYB29358.1;EFA12460.1;EFA02132.1;KYB26689.1;KYB27221.1;EEZ97656.1;EFA03430.2;KYB27220.1;EFA12193.1;EFA12278.1;EFA09107.1;EFA05083.2;EFA08691.1;EFA07968.1;EFA13468.1;EEZ98801.1;EFA13680.1;EFA12309.1;EFA09487.1;EEZ97257.1;EEZ99784.2;KYB27110.1;EFA12575.1;EFA07860.2;KXZ75683.1 MetaCyc: PWY-6859 All-trans-farnesol biosynthesis 1 EFA07280.1 MetaCyc: PWY-6987 Lipoate biosynthesis and incorporation III (Bacillus) 4 EFA05264.2;EFA02475.1;EEZ98826.2;EFA10961.1 Reactome: R-HSA-975577 N-Glycan antennae elongation 4 EFA12917.2;EFA08717.1;KXZ75832.1;EFA09998.1 Reactome: R-HSA-416993 Trafficking of GluR2-containing AMPA receptors 3 EFA11378.1;EFA09781.1;EFA11263.1 Reactome: R-HSA-354192 Integrin signaling 1 EFA00152.1 KEGG: 00860+2.5.1.141 Porphyrin and chlorophyll metabolism 1 KYB25345.1 Reactome: R-HSA-3249367 STAT6-mediated induction of chemokines 1 EFA08516.2 KEGG: 00010+4.2.1.11 Glycolysis / Gluconeogenesis 3 EFA10506.1;EFA09609.1;EFA09610.1 Reactome: R-HSA-73728 RNA Polymerase I Promoter Opening 1 KYB24563.1 KEGG: 00230+2.7.1.40 Purine metabolism 7 KYB24934.1;EFA08832.2;KYB25941.1;EEZ97193.2;KYB24935.1;EFA08842.1;EEZ99016.2 Reactome: R-HSA-162594 Early Phase of HIV Life Cycle 1 EFA06383.1 Reactome: R-HSA-9630222 Defective NTHL1 substrate binding 1 EFA08192.2 KEGG: 00650+4.2.1.17 Butanoate metabolism 1 EFA04382.1 Reactome: R-HSA-73980 RNA Polymerase III Transcription Termination 15 EFA07935.1;EEZ99545.1;EFA03150.1;EFA07031.1;EFA07284.1;KYB26001.1;KYB28470.1;EFA10944.1;KYB26491.1;EFA11622.1;EFA01191.1;EFA02494.1;EFA05896.1;EFA07655.1;EFA09807.1 KEGG: 00710+1.2.1.12 Carbon fixation in photosynthetic organisms 2 EFA07763.1;EFA08517.1 KEGG: 00590+3.1.1.4 Arachidonic acid metabolism 23 EEZ99784.2;EFA12575.1;KXZ75683.1;EFA07860.2;EFA09487.1;EFA12309.1;EFA13680.1;EEZ98801.1;EFA07968.1;EFA13468.1;EFA08691.1;EFA09107.1;EFA12278.1;EFA05083.2;EFA03430.2;EFA12193.1;KYB27220.1;KYB27221.1;KYB26689.1;EFA12460.1;KYB29358.1;KYB27219.1;EFA11812.1 KEGG: 00640+6.2.1.1 Propanoate metabolism 2 EFA12933.2;EFA12019.1 Reactome: R-HSA-1483255 PI Metabolism 1 EEZ99081.2 Reactome: R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry 6 EFA06469.1;EFA02105.1;EFA08856.2;EFA01741.1;EFA07055.2;EFA02434.1 Reactome: R-HSA-8853383 Lysosomal oligosaccharide catabolism 13 EEZ99706.1;KYB25899.1;KYB26528.1;KYB25898.1;EEZ99703.1;KYB25900.1;EFA08768.2;KYB26527.1;EFA08765.1;EEZ99705.1;EFA06933.2;EFA08767.1;EEZ99704.1 Reactome: R-HSA-1445148 Translocation of SLC2A4 (GLUT4) to the plasma membrane 27 EEZ99070.2;EFA06250.1;EEZ97229.1;EEZ99348.1;EFA08461.1;EFA04473.2;EFA05559.2;EFA12018.2;KYB26929.1;EFA06663.1;EFA11005.2;EEZ98592.2;EFA04833.1;EFA09822.2;EFA11292.1;EFA02004.1;EFA01451.2;EEZ99331.1;EFA06187.1;KYB26625.1;KYB28971.1;EEZ97223.1;EFA08190.1;EFA08819.1;EEZ97195.1;EEZ97891.1;EFA11086.1 MetaCyc: PWY-5123 Trans, trans-farnesyl diphosphate biosynthesis 1 EFA07280.1 KEGG: 00970+6.1.1.22 Aminoacyl-tRNA biosynthesis 2 EFA01641.1;EEZ97370.1 KEGG: 00790+1.1.1.153 Folate biosynthesis 1 EFA08713.1 KEGG: 00360+4.2.1.17 Phenylalanine metabolism 3 EFA04382.1;EFA05073.1;EFA08151.1 Reactome: R-HSA-5339716 Misspliced GSK3beta mutants stabilize beta-catenin 4 KYB26383.1;EFA05992.2;EFA13272.2;KYB26642.1 Reactome: R-HSA-76071 RNA Polymerase III Transcription Initiation From Type 3 Promoter 17 EFA05365.1;EEZ98845.2;EFA02494.1;EFA07655.1;EFA01191.1;EFA11622.1;KYB28470.1;KYB26491.1;EFA07284.1;EFA07031.1;EFA09807.1;EFA05896.1;EFA06729.1;KYB26001.1;EFA07935.1;EEZ99545.1;EFA03150.1 KEGG: 00513+2.4.1.68 Various types of N-glycan biosynthesis 2 EFA02784.1;KYB27749.1 Reactome: R-HSA-1660662 Glycosphingolipid metabolism 39 EEZ98597.1;EFA06863.2;EFA07069.1;EFA05480.2;EFA10294.2;KYB28573.1;EFA01478.2;EFA11380.2;KYB26348.1;EFA04519.2;EFA07058.2;KYB25350.1;EEZ97351.1;EFA08278.1;EEZ97353.1;EFA07971.1;EFA02388.1;EFA05963.2;KYB28198.1;EFA12048.1;EFA05960.2;EEZ97241.2;EEZ98394.2;EFA01479.1;KYB29852.1;EFA04170.2;EEZ97352.2;EFA05962.2;KYB28197.1;KYB26349.1;EFA05959.1;EFA07388.1;EFA08230.2;KYB28199.1;KYB27242.1;EFA01481.2;KYB25428.1;EFA06836.2;KYB25998.1 KEGG: 00760+6.3.5.1 Nicotinate and nicotinamide metabolism 1 EFA01802.1 Reactome: R-HSA-163615 PKA activation 18 KYB27619.1;KYB25556.1;EFA03625.2;EFA03629.2;EFA06381.2;KYB25552.1;KYB25555.1;KYB26602.1;EEZ99469.1;KYB27523.1;EFA03628.1;EFA03954.2;KYB25554.1;KYB28863.1;EFA10712.2;EFA01439.2;KYB28779.1;KYB25553.1 Reactome: R-HSA-426048 Arachidonate production from DAG 2 EFA10154.1;EFA13496.1 MetaCyc: PWY-5890 Menaquinol-10 biosynthesis 2 EFA05173.2;KYB27131.1 MetaCyc: PWY-7375 Mrna capping I 2 EFA03004.2;EFA03427.1 Reactome: R-HSA-1655829 Regulation of cholesterol biosynthesis by SREBP (SREBF) 8 EFA00011.2;KYB28740.1;KYB26644.1;EEZ98063.1;EFA01820.1;EFA06320.2;EFA10538.1;KYB24587.1 KEGG: 00071+4.2.1.17+1.1.1.35 Fatty acid degradation 3 EFA04382.1;EFA05073.1;EFA08151.1 Reactome: R-HSA-68962 Activation of the pre-replicative complex 34 EFA11589.2;EEZ97575.1;EFA04623.2;EFA09711.2;EFA09169.1;EFA13575.1;EFA11188.2;EFA12891.1;EFA10435.1;EEZ97375.1;EFA06672.2;EFA07750.2;EFA09576.1;EFA03157.1;KYB26713.1;EEZ97925.1;EFA05162.2;EFA10460.1;EFA12381.1;EFA07996.1;KYB29174.1;EFA00549.1;EFA03095.1;EFA06929.1;EFA06374.2;EFA09906.2;EFA06047.1;EFA05648.1;KYB27483.1;EFA06449.1;KYB26668.1;EFA03620.1;EFA06648.2;EFA05016.1 KEGG: 00270+2.6.1.42 Cysteine and methionine metabolism 1 EEZ98004.1 Reactome: R-HSA-5610780 Degradation of GLI1 by the proteasome 42 EFA02110.1;EEZ99493.1;EFA02345.1;EFA13218.1;EFA08911.2;KYB27557.1;KYB29360.1;EFA03341.1;KYB26764.1;EFA02847.1;KYB27556.1;EEZ97876.1;EFA08664.1;EFA06200.1;EFA06741.1;EFA06519.1;EFA11079.1;EFA08798.1;EFA09524.2;EFA05865.1;EFA04054.1;EFA07261.2;EEZ97564.1;EFA05105.1;EFA03019.1;EFA02331.1;EEZ98185.1;EFA09518.2;EFA07659.2;EFA05871.2;EFA08601.1;EFA07110.1;EFA05912.1;KYB29359.1;KYB26545.1;EFA05370.2;KYB25309.1;EFA04284.1;KYB24713.1;EFA05833.1;KYB29272.1;EEZ99004.1 Reactome: R-HSA-8939236 RUNX1 regulates transcription of genes involved in differentiation of HSCs 46 KYB27557.1;KYB29360.1;EEZ99493.1;EFA08911.2;EFA13218.1;EFA02345.1;KYB24563.1;EFA02110.1;EFA12165.2;EFA06741.1;EFA11079.1;EFA06519.1;EFA08664.1;EFA06200.1;KYB27556.1;EEZ97876.1;KYB26764.1;EFA03341.1;EFA07659.2;KYB27618.1;EFA05871.2;EFA09518.2;EFA08601.1;EFA06469.1;EFA03019.1;EFA05105.1;EFA03630.2;EEZ98185.1;EFA02331.1;EEZ97564.1;EFA07261.2;EFA09524.2;EFA08798.1;EFA05865.1;EFA07055.2;EFA04054.1;EEZ99004.1;EFA05833.1;KYB24713.1;EFA05370.2;EFA04284.1;KYB25309.1;KYB26545.1;EFA07110.1;EFA05912.1;KYB29359.1 KEGG: 00720+2.3.3.8 Carbon fixation pathways in prokaryotes 1 EFA05014.1 KEGG: 00230+6.3.4.13 Purine metabolism 1 KYB25818.1 MetaCyc: PWY-7180 2-deoxy-alpha-D-ribose 1-phosphate degradation 1 EFA12496.1 Reactome: R-HSA-2565942 Regulation of PLK1 Activity at G2/M Transition 21 KYB29359.1;EFA02847.1;KYB27666.1;EEZ98528.1;EEZ99274.1;EFA07920.2;EEZ97959.1;EFA02110.1;EFA09710.1;KYB25744.1;EFA09381.2;KYB28460.1;EFA05098.1;KYB28459.1;EFA10255.2;KYB25597.1;KYB26566.1;EFA03783.1;EFA06332.2;KYB29360.1;EFA02136.2 MetaCyc: PWY-7205 CMP phosphorylation 5 EFA03917.1;EEZ99726.1;EFA07171.1;KYB26165.1;EEZ98594.1 KEGG: 00250+6.3.1.2 Alanine, aspartate and glutamate metabolism 2 EEZ99821.1;EEZ97848.1 MetaCyc: PWY-6807 Xyloglucan degradation II (exoglucanase) 12 EFA00166.1;EFA07841.1;KYB28627.1;EEZ99316.1;KYB26528.1;EEZ99315.1;EFA04110.1;EFA07842.1;KYB28628.1;EEZ97806.1;EFA07843.2;EFA06933.2 KEGG: 00710+5.3.1.6 Carbon fixation in photosynthetic organisms 1 EFA01628.1 MetaCyc: PWY-5057 L-valine degradation II 2 EEZ98004.1;EEZ98950.2 Reactome: R-HSA-156902 Peptide chain elongation 74 EFA03478.1;EFA03441.1;EFA09345.2;EEZ98858.1;KYB27741.1;EEZ98503.1;EFA02257.1;EFA11360.1;EFA03236.1;EFA10462.1;EFA10173.2;KYB29360.1;EFA02592.1;EFA05803.1;EEZ97360.2;EFA10183.1;EFA01765.1;KYB26424.1;KYB27801.1;EFA11293.1;EFA04159.1;EFA09970.1;KYB29621.1;EEZ99023.1;EFA05373.1;EFA12204.1;EEZ97645.1;KYB27481.1;EFA01051.1;EFA02554.1;EFA09390.1;EFA10969.1;EFA03166.1;EEZ98852.1;EFA07317.1;EFA04120.1;EFA05471.1;EFA00163.1;EFA02110.1;EFA11837.1;EFA08168.1;EFA08849.1;EFA00505.1;EFA07030.1;EFA05867.1;EFA01805.1;EFA03533.1;EFA02992.1;EFA00935.2;EEZ97412.1;EEZ97313.1;EFA06382.1;EFA10201.2;EFA08054.1;EFA09067.1;EFA01731.1;EEZ98728.1;EFA13254.1;EFA09212.1;EFA08624.1;EFA06341.1;EFA06574.1;KYB27567.1;KYB29359.1;EFA04453.1;EFA02145.1;EEZ97379.1;EFA06534.1;EFA05170.2;EFA03346.1;EFA02268.1;EEZ99099.1;EFA07141.1;EFA04946.1 Reactome: R-HSA-3359462 Defective AMN causes hereditary megaloblastic anemia 1 1 EFA05060.1 Reactome: R-HSA-204626 Hypusine synthesis from eIF5A-lysine 2 EFA09033.1;EEZ99689.1 KEGG: 00561+3.1.1.3 Glycerolipid metabolism 2 EFA10312.1;KYB25598.1 KEGG: 00240+2.1.3.2 Pyrimidine metabolism 1 EFA10197.1 KEGG: 00620+6.4.1.1 Pyruvate metabolism 1 KYB27787.1 MetaCyc: PWY-5872 Ubiquinol-10 biosynthesis (eukaryotic) 3 KYB26214.1;KYB26307.1;EFA04400.1 MetaCyc: PWY-5142 Acyl-[acyl-carrier protein] thioesterase pathway 7 EFA05249.2;EFA05201.1;EFA05204.2;EFA05203.2;EFA05248.1;EFA11365.1;EEZ97866.2 KEGG: 00520+3.5.99.6 Amino sugar and nucleotide sugar metabolism 3 EFA02005.2;EFA08071.1;EFA00108.1 KEGG: 00620+1.1.1.37 Pyruvate metabolism 2 EFA02482.1;EFA04972.1 Reactome: R-HSA-5625900 RHO GTPases activate CIT 1 KYB26957.1 Reactome: R-HSA-4793954 Defective MOGS causes MOGS-CDG (CDG-2b) 1 KYB25099.1 Reactome: R-HSA-141430 Inactivation of APC/C via direct inhibition of the APC/C complex 12 EEZ98737.1;EEZ98849.2;EFA01569.1;EEZ97989.1;KYB25814.1;EFA01854.1;KYB27187.1;EFA04231.1;EFA00073.1;EEZ99272.2;KYB27271.1;EEZ97189.1 MetaCyc: PWY-7778 2-methylpropene degradation 3 EFA08151.1;EFA05073.1;EFA04382.1 KEGG: 00533+2.4.1.68 Glycosaminoglycan biosynthesis - keratan sulfate 2 EFA02784.1;KYB27749.1 MetaCyc: PWY-7831 ABH and Lewis epitopes biosynthesis from type 2 precursor disaccharide 1 EEZ98997.2 Reactome: R-HSA-5357905 Regulation of TNFR1 signaling 4 KYB29360.1;KYB27252.1;EFA02110.1;KYB29359.1 MetaCyc: PWY-6453 Stigma estolide biosynthesis 10 EEZ97257.1;EEZ97656.1;EFA09975.1;EFA02132.1;KYB27110.1;KYB26367.1;EFA07054.2;KYB27111.1;EFA06119.2;EFA04525.1 Reactome: R-HSA-3359471 Defective MMAB causes methylmalonic aciduria type cblB 1 EFA10463.1 KEGG: 00760+6.3.4.21 Nicotinate and nicotinamide metabolism 2 EFA10857.2;EEZ97420.1 MetaCyc: PWY-6863 Pyruvate fermentation to hexanol (engineered) 3 EFA05073.1;EFA08151.1;EFA04382.1 KEGG: 00071+1.14.14.1 Fatty acid degradation 1 EFA05733.1 Reactome: R-HSA-187577 SCF(Skp2)-mediated degradation of p27/p21 39 EFA07110.1;EFA05912.1;KYB29359.1;KYB26545.1;EFA05370.2;EFA04284.1;KYB25309.1;EFA05833.1;EEZ99004.1;KYB24713.1;EFA09524.2;EFA08798.1;EFA05865.1;EFA04054.1;EEZ97564.1;EFA03019.1;EFA05105.1;EFA02331.1;EEZ98185.1;EFA07659.2;EFA05871.2;EFA09518.2;EFA08601.1;EFA03341.1;EFA02847.1;KYB27556.1;EEZ97876.1;EFA08664.1;EFA06200.1;EFA06741.1;EFA11079.1;EFA06519.1;EFA02110.1;EEZ99493.1;EFA08911.2;EFA13218.1;EFA02345.1;KYB27557.1;KYB29360.1 Reactome: R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models 2 EFA12824.1;EFA09191.1 Reactome: R-HSA-3359473 Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD 1 EEZ98479.1 KEGG: 00750+1.4.3.5 Vitamin B6 metabolism 2 EFA10196.1;KYB25431.1 Reactome: R-HSA-5083630 Defective LFNG causes SCDO3 2 EEZ97204.1;KYB24943.1 Reactome: R-HSA-202040 G-protein activation 3 EFA04253.1;EFA10835.1;KYB25864.1 MetaCyc: PWY-3661 Glycine betaine degradation I 1 EFA09131.1 KEGG: 00790+4.2.3.12 Folate biosynthesis 1 EFA05403.1 Reactome: R-HSA-70921 Histidine catabolism 2 EFA06463.1;KYB26333.1 Reactome: R-HSA-9620244 Long-term potentiation 4 EFA09715.1;EEZ99807.2;KYB28360.1;KYB29108.1 MetaCyc: PWY-7395 D-galactosamine and N-acetyl-D-galactosamine degradation 1 KYB27794.1 Reactome: R-HSA-211945 Phase I - Functionalization of compounds 5 EFA00566.1;EFA00170.1;EFA00568.1;EFA00567.1;EFA00569.1 KEGG: 00330+1.2.1.88 Arginine and proline metabolism 1 EFA05239.1 KEGG: 00062+4.2.1.134 Fatty acid elongation 2 EFA05143.1;EFA03551.1 KEGG: 00513+2.4.1.143 Various types of N-glycan biosynthesis 1 EFA12804.1 KEGG: 00670+1.5.1.5+3.5.4.9 One carbon pool by folate 2 EFA07809.2;EFA07236.1 KEGG: 00270+6.3.2.2 Cysteine and methionine metabolism 1 EFA04528.1 KEGG: 00250+2.6.1.16 Alanine, aspartate and glutamate metabolism 2 EEZ99805.2;KYB28361.1 Reactome: R-HSA-75105 Fatty acyl-CoA biosynthesis 24 KYB27097.1;EFA05209.1;EFA11379.1;EFA05014.1;EFA12397.2;EFA05204.2;EEZ98125.1;EEZ97602.1;EFA12797.1;EFA12413.1;EFA05022.2;EFA12412.2;EFA02059.2;EFA00770.1;EFA11365.1;EFA12798.2;EFA05201.1;EFA05249.2;EEZ97866.2;EFA05245.2;KYB27107.1;EFA05203.2;EFA05248.1;EFA12799.1 Reactome: R-HSA-1266695 Interleukin-7 signaling 1 KYB29656.1 Reactome: R-HSA-5658034 HHAT G278V abrogates palmitoylation of Hh-Np 1 KYB28973.1 KEGG: 00531+3.2.1.52 Glycosaminoglycan degradation 10 EFA05959.1;EFA11380.2;EFA08995.1;EFA06836.2;KYB25657.1;EFA05960.2;EEZ98597.1;EFA10268.1;EFA07069.1;EFA06863.2 Reactome: R-HSA-167290 Pausing and recovery of HIV elongation 21 EFA07148.1;EFA00397.1;EFA05446.1;EFA05896.1;KYB25207.1;KYB25152.1;EFA05226.1;EFA10605.2;KYB26001.1;EFA06560.1;EFA03150.1;EFA03550.1;EFA08590.1;EFA12997.1;EFA04061.1;EFA10288.1;KYB28470.1;EEZ97398.2;EFA07031.1;EFA00606.1;EFA00603.1 MetaCyc: PWY-7841 Neolacto-series glycosphingolipids biosynthesis 1 EFA12048.1 KEGG: 00970+6.1.1.11 Aminoacyl-tRNA biosynthesis 2 EEZ97530.1;EFA06843.2 Reactome: R-HSA-5696397 Gap-filling DNA repair synthesis and ligation in GG-NER 23 EFA06672.2;EFA02110.1;KYB25721.1;EEZ98905.1;EFA09906.2;EFA12891.1;KYB25740.1;KYB29360.1;KYB28926.1;EFA08812.2;KYB27483.1;KYB29442.1;EFA08916.1;EFA09711.2;EFA06042.1;EFA07958.1;EFA12420.2;KYB29359.1;KYB28925.1;KYB26713.1;EFA03020.2;EFA02756.1;EFA03814.1 MetaCyc: PWY-7574 Propanoyl-coa degradation II 3 EFA09569.1;EFA11530.1;EFA09425.1 KEGG: 00790+3.4.19.9 Folate biosynthesis 2 KYB28918.1;EFA00210.2 Reactome: R-HSA-8948751 Regulation of PTEN stability and activity 43 EFA03019.1;EFA05105.1;EFA02331.1;EEZ98185.1;EFA07659.2;EFA05871.2;EFA09518.2;EFA08601.1;EFA09524.2;EFA08798.1;EFA04054.1;EFA05865.1;EEZ97564.1;EFA07261.2;EFA05370.2;KYB25309.1;EFA04284.1;EFA05833.1;EEZ99004.1;KYB24713.1;EEZ97852.2;EFA07110.1;EFA05912.1;KYB29359.1;KYB26545.1;EFA02105.1;EFA08658.1;EEZ99493.1;EFA08911.2;EFA13218.1;EFA02345.1;KYB27557.1;KYB29360.1;EFA02110.1;EFA08664.1;EFA06200.1;EFA06741.1;EFA11079.1;EFA06519.1;KYB26764.1;EFA03341.1;KYB27556.1;EEZ97876.1 Reactome: R-HSA-68827 CDT1 association with the CDC6:ORC:origin complex 50 KYB27556.1;EEZ97876.1;EFA03341.1;KYB26764.1;EFA06519.1;EFA11079.1;EFA06741.1;EFA06200.1;EFA08664.1;EFA02110.1;EFA03157.1;KYB29360.1;EFA11188.2;KYB27557.1;EFA13218.1;EFA02345.1;EFA08911.2;EEZ99493.1;KYB29174.1;EFA00549.1;KYB26545.1;EFA03095.1;EFA05912.1;KYB29359.1;EFA06929.1;EFA07110.1;EFA10460.1;EFA05162.2;KYB24713.1;EFA05833.1;EEZ99004.1;KYB25309.1;EFA04284.1;EFA05370.2;EFA07261.2;EEZ97564.1;EFA05865.1;EFA04054.1;EFA08798.1;EFA09524.2;EFA06374.2;EFA08601.1;EFA09518.2;EFA07659.2;EFA05871.2;EFA06047.1;EEZ98185.1;EFA02331.1;EFA05105.1;EFA03019.1 Reactome: R-HSA-181430 Norepinephrine Neurotransmitter Release Cycle 4 KYB29539.1;KYB29538.1;EEZ99137.2;KYB29537.1 MetaCyc: PWY-7227 Adenosine deoxyribonucleotides de novo biosynthesis 8 EFA02202.1;EFA02203.1;EEZ98594.1;KYB26165.1;EFA07171.1;EFA03917.1;EFA03825.1;EEZ99726.1 Reactome: R-HSA-167246 Tat-mediated elongation of the HIV-1 transcript 28 KYB25378.1;EFA05226.1;KYB25152.1;EFA03150.1;EFA03550.1;EFA08590.1;EFA10605.2;EFA06560.1;KYB26001.1;EFA00328.1;EFA07148.1;EFA00397.1;KYB25207.1;EFA05446.1;EFA05896.1;EFA00018.1;KYB28470.1;EFA06469.1;EFA07031.1;EFA00606.1;EFA00603.1;EEZ97398.2;EFA12997.1;EFA07302.1;EFA07055.2;EFA04061.1;EFA10288.1;EFA02310.1 MetaCyc: PWY-7536 2-amino-3-hydroxycyclopent-2-enone biosynthesis 1 EFA03355.2 KEGG: 00051+2.7.1.11 Fructose and mannose metabolism 2 EFA08228.2;KYB26002.1 Reactome: R-HSA-9022692 Regulation of MECP2 expression and activity 11 EFA11590.1;KYB25778.1;KYB25999.1;KYB26000.1;KYB28360.1;EFA09197.2;EEZ99807.2;EFA07303.1;EFA04626.2;EFA10047.2;EFA08972.2 Reactome: R-HSA-427975 Proton/oligopeptide cotransporters 6 EFA00587.2;KYB28638.1;EFA00586.2;KYB28637.1;EFA00584.2;KYB28639.1 KEGG: 00230+4.6.1.1 Purine metabolism 15 EFA03629.2;KYB25554.1;KYB28863.1;EFA03625.2;KYB27523.1;EFA03628.1;KYB25556.1;EFA03954.2;KYB27619.1;KYB25553.1;KYB25555.1;KYB25552.1;EFA01439.2;EFA01517.1;EFA10712.2 KEGG: 00360+1.14.16.1 Phenylalanine metabolism 1 EEZ99507.1 MetaCyc: PWY-5905 Hypusine biosynthesis 1 EFA09033.1 KEGG: 04660+3.1.3.16 T cell receptor signaling pathway 39 EFA08945.1;EEZ97359.1;KYB27758.1;EFA09896.1;KYB26880.1;KYB27757.1;EFA04151.1;KYB25190.1;EEZ99522.2;KYB28233.1;EFA10861.1;EFA02685.2;EFA05189.1;EFA03763.1;KYB25565.1;EFA02473.2;EFA07329.1;EFA07805.1;KYB28159.1;EFA04777.2;EFA00145.2;KYB28443.1;EFA05539.2;EFA10433.2;EFA03107.1;KYB25189.1;EFA06120.1;KYB28677.1;EFA13210.1;EFA00642.2;EFA01582.2;EFA04890.1;EFA07148.1;EFA10810.2;EFA11234.1;KYB25187.1;KYB28676.1;KYB28792.1;KYB27031.1 Reactome: R-HSA-1236974 ER-Phagosome pathway 44 EFA08664.1;EFA06200.1;EFA06741.1;EFA06519.1;EFA11079.1;EFA03341.1;KYB26764.1;EEZ97876.1;KYB27556.1;EFA03379.1;EEZ99493.1;EFA02345.1;EFA13218.1;EFA08911.2;KYB27557.1;EFA01706.1;KYB29360.1;EFA02110.1;EFA05370.2;KYB25309.1;EFA04284.1;KYB24713.1;EEZ99004.1;EFA05833.1;EFA01230.1;EFA01304.1;EFA07110.1;KYB29359.1;EFA05912.1;KYB26545.1;EFA05105.1;EFA03019.1;EFA02331.1;EEZ98185.1;EFA09518.2;EFA07659.2;EFA05871.2;EFA08601.1;EFA08798.1;EFA09524.2;EFA04054.1;EFA05865.1;EFA07261.2;EEZ97564.1 Reactome: R-HSA-72086 mRNA Capping 22 EFA05446.1;EFA05896.1;EFA00328.1;EFA03150.1;EFA03550.1;EFA03004.2;KYB26001.1;EFA06560.1;KYB25378.1;EFA05226.1;KYB25152.1;EFA07302.1;EFA07055.2;EFA02310.1;EEZ98144.2;EEZ98143.1;EFA07031.1;EFA03427.1;EEZ97398.2;EFA00018.1;KYB28470.1;EFA06469.1 KEGG: 00920+2.8.1.1 Sulfur metabolism 1 EFA06486.2 Reactome: R-HSA-1296072 Voltage gated Potassium channels 14 EFA08936.1;EFA07362.2;EFA00701.2;KYB25650.1;EFA08935.1;EFA09395.2;KYB28707.1;EFA11047.2;EFA02167.1;KYB28116.1;EFA05339.2;EFA03256.1;EFA02607.1;EFA10968.1 Reactome: R-HSA-163680 AMPK inhibits chREBP transcriptional activation activity 1 EFA10720.1 Reactome: R-HSA-1912399 Pre-NOTCH Processing in the Endoplasmic Reticulum 2 EEZ97204.1;KYB24943.1 Reactome: R-HSA-167238 Pausing and recovery of Tat-mediated HIV elongation 21 EFA05896.1;EFA05446.1;KYB25207.1;EFA00397.1;EFA07148.1;KYB26001.1;EFA06560.1;EFA10605.2;EFA08590.1;EFA03550.1;EFA03150.1;KYB25152.1;EFA05226.1;EFA04061.1;EFA10288.1;EFA12997.1;EEZ97398.2;EFA00603.1;EFA00606.1;EFA07031.1;KYB28470.1 KEGG: 00562+2.7.1.137 Inositol phosphate metabolism 1 EEZ98191.1 Reactome: R-HSA-9028731 Activated NTRK2 signals through FRS2 and FRS3 1 EFA09507.1 Reactome: R-HSA-203754 NOSIP mediated eNOS trafficking 1 EFA00996.1 Reactome: R-HSA-2995383 Initiation of Nuclear Envelope Reformation 1 EFA05796.2 Reactome: R-HSA-5662702 Melanin biosynthesis 10 EFA09146.1;EFA09147.2;EFA09266.1;EFA09144.1;EFA05644.1;EFA09145.1;EFA09253.1;EEZ99189.1;EFA05662.1;KYB26937.1 MetaCyc: PWY-4981 L-proline biosynthesis II (from arginine) 4 EFA12217.1;EFA00672.1;EEZ98115.1;EEZ98116.1 MetaCyc: PWY-7174 S-methyl-5-thio-alpha-D-ribose 1-phosphate degradation II 4 EEZ97197.1;EFA12349.2;EFA02518.1;EFA12261.1 Reactome: R-HSA-5609978 Defective GALT can cause Galactosemia 1 KYB28384.1 Reactome: R-HSA-389357 CD28 dependent PI3K/Akt signaling 6 KYB29656.1;EFA02105.1;EFA10417.1;EFA07964.1;EEZ99088.1;EFA00152.1 Reactome: R-HSA-5627117 RHO GTPases Activate ROCKs 2 EFA04406.2;KYB27402.1 KEGG: 00630+4.2.1.3 Glyoxylate and dicarboxylate metabolism 2 EFA08121.1;EFA02996.1 KEGG: 00670+2.1.2.3 One carbon pool by folate 1 EEZ98830.1 Reactome: R-HSA-76061 RNA Polymerase III Transcription Initiation From Type 1 Promoter 20 EFA03073.1;EFA07031.1;EFA07284.1;KYB28470.1;KYB26491.1;EFA11622.1;EFA01191.1;EFA02494.1;EFA07655.1;EEZ99545.1;EFA07935.1;EFA03150.1;KYB26001.1;KYB26468.1;EFA06729.1;EEZ97248.2;EEZ99572.2;EFA05896.1;EFA06650.2;EFA09807.1 KEGG: 00901+2.7.1.222 Indole alkaloid biosynthesis 35 EFA07198.1;EEZ97589.1;EFA06725.1;EFA07343.1;EFA03938.1;EFA06727.1;KYB25888.1;EEZ98805.1;KYB27090.1;EFA06294.1;EFA02417.1;EFA02416.1;EFA06293.1;EFA03626.1;KYB26266.1;EFA06719.1;EFA03939.1;EFA06831.1;EFA03261.1;EFA06721.1;EFA06724.1;EFA06728.1;EFA06295.2;EFA06726.1;EFA03937.1;KYB27902.1;EFA06830.2;EFA03627.2;EFA06722.2;EFA05154.1;EFA06720.1;EFA00204.1;EFA06723.1;EFA02038.1;EFA06832.1 Reactome: R-HSA-209560 NF-kB is activated and signals survival 4 KYB29359.1;EFA02110.1;KYB29360.1;EFA02851.1 KEGG: 00620+3.6.1.7 Pyruvate metabolism 2 EFA09358.1;KYB26572.1 Reactome: R-HSA-9665249 Resistance of ERBB2 KD mutants to afatinib 1 EFA03198.1 MetaCyc: PWY-7766 Heme b biosynthesis IV (Gram-positive bacteria) 1 KYB29726.1 MetaCyc: PWY-6855 Chitin degradation I (archaea) 23 EFA06698.1;EFA06694.1;EFA06311.1;EFA02005.2;EFA06307.1;EFA10939.1;EFA06695.1;EFA05323.2;EFA06923.1;EFA00108.1;EFA00965.2;EFA06310.1;KYB26650.1;EFA06308.1;EFA05481.2;EFA06309.1;EFA06699.2;KYB26651.1;KYB26649.1;EFA06696.2;EFA10488.1;EFA06693.1;EFA08071.1 Reactome: R-HSA-4719360 Defective DPM3 causes DPM3-CDG (CDG-1o) 2 EFA04846.1;EFA06224.2 Reactome: R-HSA-6807878 COPI-mediated anterograde transport 52 KYB25071.1;KYB26625.1;EFA01607.2;EFA03151.1;KYB28283.1;EEZ99331.1;EFA06187.1;KYB25072.1;EFA03756.1;KYB28369.1;EFA10421.1;KYB29402.1;EEZ99348.1;EFA09381.2;KYB26929.1;KYB29922.1;EFA09678.1;EFA10255.2;EEZ99070.2;EFA05068.1;EFA03811.1;EFA08682.1;EFA09822.2;EFA13206.2;EFA11398.1;EEZ97487.2;KYB28368.1;EFA12234.1;EEZ97891.1;KYB28284.1;EEZ98676.1;KYB28281.1;EFA10214.2;KYB28285.1;EFA06663.1;EEZ97538.1;KYB28367.1;EEZ97229.1;EFA07749.1;EFA00369.1;EFA11292.1;EFA03783.1;EFA09305.2;KYB25597.1;EFA06446.1;KYB26892.1;EFA11346.2;EFA02659.1;EFA04833.1;EEZ98209.1;EFA09340.1;EEZ99233.1 KEGG: 00330+1.5.1.2 Arginine and proline metabolism 3 EEZ98116.1;EEZ98115.1;EFA00672.1 Reactome: R-HSA-400253 Circadian Clock 18 EFA08558.1;EFA04537.1;KYB28159.1;KYB26838.1;EFA02847.1;KYB29359.1;EFA02685.2;EFA02517.2;EFA00806.2;EFA05189.1;EFA06486.2;KYB27758.1;KYB29360.1;KYB27757.1;KYB28596.1;EFA02110.1;KYB28595.1;EFA10996.1 Reactome: R-HSA-2142789 Ubiquinol biosynthesis 7 EFA04400.1;EFA05173.2;KYB26590.1;EFA00305.1;KYB26214.1;KYB27131.1;KYB26307.1 MetaCyc: PWY-4983 Nitric oxide biosynthesis II (mammals) 4 EFA10400.2;EFA11668.2;KYB25321.1;EEZ97516.1 MetaCyc: PWY-5921 Glutaminyl-trnagln biosynthesis via transamidation 1 EFA11037.2 Reactome: R-HSA-70370 Galactose catabolism 4 KYB28384.1;EFA06422.2;EFA06670.2;KYB26631.1 KEGG: 00030+5.3.1.6 Pentose phosphate pathway 1 EFA01628.1 Reactome: R-HSA-3000480 Scavenging by Class A Receptors 6 KYB29705.1;KYB29706.1;EFA11302.1;KYB29704.1;KYB26997.1;EFA11425.1 Reactome: R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening 30 EFA06253.1;EFA03052.1;EFA00328.1;EFA03093.1;EFA05896.1;EFA00911.1;KYB25152.1;EFA05226.1;EFA02321.1;KYB25378.1;KYB29037.1;EFA05523.2;KYB26001.1;EFA06560.1;EFA11878.1;EFA03550.1;EFA03150.1;EFA02310.1;EFA07055.2;EFA07302.1;EFA06469.1;EEZ97886.2;EEZ99738.1;KYB28470.1;EFA00018.1;EEZ97398.2;KYB29038.1;EFA05897.1;EFA03759.1;EFA07031.1 MetaCyc: PWY-7919 Protein N-glycosylation processing phase (plants and animals) 2 KYB25099.1;EFA08227.2 Reactome: R-HSA-70263 Gluconeogenesis 16 EFA02482.1;EFA04932.1;EFA09610.1;KYB27612.1;EFA09609.1;KYB26254.1;EFA10506.1;EFA01748.1;EFA07687.2;EFA05374.1;EFA08517.1;EFA07763.1;EFA04972.1;EEZ98675.1;KYB27787.1;EFA06223.2 MetaCyc: PWY-7883 Anhydromuropeptides recycling II 10 EFA05960.2;EEZ98597.1;EFA10268.1;EFA06863.2;EFA07069.1;EFA05959.1;EFA11380.2;EFA08995.1;KYB25657.1;EFA06836.2 MetaCyc: PWY-7184 Pyrimidine deoxyribonucleotides de novo biosynthesis I 15 EFA08206.2;EEZ98594.1;EFA07171.1;KYB26165.1;KYB29374.1;EFA02202.1;EFA02203.1;EFA02095.1;EFA03825.1;EFA04414.1;EFA03919.1;EEZ99726.1;EFA00847.2;EFA03917.1;EFA11748.1 KEGG: 00020+6.4.1.1 Citrate cycle (TCA cycle) 1 KYB27787.1 MetaCyc: PWY-6030 Serotonin and melatonin biosynthesis 1 EFA01002.1 KEGG: 00250+3.5.1.1 Alanine, aspartate and glutamate metabolism 4 EFA08342.2;EEZ98638.1;EFA08343.2;EFA06327.1 Reactome: R-HSA-6807004 Negative regulation of MET activity 11 EFA09116.1;EFA11193.1;EFA01732.2;KYB29360.1;EFA00470.2;KYB29359.1;EFA02110.1;EFA02044.2;EFA04011.1;KYB28833.1;KYB27808.1 Reactome: R-HSA-1855167 Synthesis of pyrophosphates in the cytosol 6 EFA10622.1;KYB25213.1;EFA02124.1;KYB26507.1;KYB26510.1;KYB26511.1 Reactome: R-HSA-174048 APC/C:Cdc20 mediated degradation of Cyclin B 15 EEZ98849.2;EEZ98737.1;KYB29360.1;EEZ97989.1;EFA01569.1;KYB25814.1;EFA00073.1;EFA04231.1;KYB27187.1;EFA01854.1;EEZ97189.1;KYB27271.1;KYB29359.1;EFA02110.1;EEZ99272.2 Reactome: R-HSA-77108 Utilization of Ketone Bodies 1 EFA09594.1 Reactome: R-HSA-380270 Recruitment of mitotic centrosome proteins and complexes 24 EFA02278.2;KYB25597.1;KYB26566.1;EFA03783.1;EFA02136.2;EFA06332.2;EFA04833.1;EFA04217.1;EFA06296.1;KYB26929.1;KYB25744.1;EFA09381.2;KYB28460.1;EFA05098.1;KYB28459.1;EFA10255.2;EFA12394.2;EFA07920.2;EEZ97959.1;KYB29312.1;KYB26030.1;EFA07171.1;KYB27666.1;EEZ98528.1 MetaCyc: PWY-7746 Mycobacterial sulfolipid biosynthesis 7 EFA05248.1;EFA11365.1;EEZ97866.2;EFA05201.1;EFA05249.2;EFA05204.2;EFA05203.2 Reactome: R-HSA-8851805 MET activates RAS signaling 1 EFA04252.1 KEGG: 00130+1.14.99.60 Ubiquinone and other terpenoid-quinone biosynthesis 1 EFA04400.1 KEGG: 00513+2.4.1.131 Various types of N-glycan biosynthesis 1 EFA05431.1 KEGG: 00670+1.5.1.3 One carbon pool by folate 1 EFA07671.2 KEGG: 00010+2.7.1.11 Glycolysis / Gluconeogenesis 2 KYB26002.1;EFA08228.2 Reactome: R-HSA-416476 G alpha (q) signalling events 25 EEZ97715.2;EFA07880.1;KYB27786.1;EFA09272.1;EFA09262.1;KYB29172.1;EEZ98203.2;EFA07516.1;EEZ97729.2;EFA10037.1;KYB27925.1;KYB25112.1;KYB25864.1;KYB29656.1;EFA07580.2;EFA07881.1;EFA04708.1;EEZ97719.2;EFA02808.2;KYB27541.1;EFA02911.1;EFA02835.2;EEZ99366.2;EFA04640.2;KYB25711.1 KEGG: 00562+1.13.99.1 Inositol phosphate metabolism 1 EFA05415.1 Reactome: R-HSA-74749 Signal attenuation 1 EFA10708.1 Reactome: R-HSA-3238698 WNT ligand biogenesis and trafficking 11 EFA11738.1;EFA04621.2;KYB26594.1;EFA04660.2;EFA05502.1;EFA07476.1;EFA04620.2;EFA04668.1;EFA07553.2;EFA04661.2;EFA05820.1 MetaCyc: PWY-5154 L-arginine biosynthesis III (via N-acetyl-L-citrulline) 3 EFA10197.1;EEZ97516.1;EFA11668.2 KEGG: 00520+2.7.7.9 Amino sugar and nucleotide sugar metabolism 1 EFA06874.2 MetaCyc: PWY-5082 L-methionine degradation III 1 EEZ98950.2 MetaCyc: PWY-5177 Glutaryl-coa degradation 3 EFA04382.1;EFA08151.1;EFA05073.1 Reactome: R-HSA-4720475 Defective ALG3 causes ALG3-CDG (CDG-1d) 1 EFA05490.1 MetaCyc: PWY-5653 NAD biosynthesis from 2-amino-3-carboxymuconate semialdehyde 2 EFA10127.2;EFA01802.1 Reactome: R-HSA-446210 Synthesis of UDP-N-acetyl-glucosamine 5 KYB27794.1;EEZ99805.2;KYB28361.1;EFA10438.1;EFA09778.2 MetaCyc: PWY-6348 Phosphate acquisition 1 KYB24625.1 Reactome: R-HSA-156842 Eukaryotic Translation Elongation 6 KYB29867.1;EFA01657.1;KYB29866.1;EFA03028.1;EFA08270.1;KYB29556.1 Reactome: R-HSA-1368082 RORA activates gene expression 7 KYB28596.1;KYB26838.1;EFA10996.1;EFA00806.2;EFA02517.2;KYB28595.1;EFA08558.1 Reactome: R-HSA-9639288 Amino acids regulate mTORC1 34 EFA00405.1;EFA12722.1;EFA02242.2;EFA10717.1;EEZ98406.2;EFA05894.1;EFA03068.1;EFA09893.1;EFA06225.1;EFA03371.1;EFA02476.1;EFA01142.2;KYB27801.1;EFA04339.1;EFA02241.1;EEZ99978.2;EFA10726.1;EFA11012.1;EFA09095.1;KYB28867.1;EFA08847.1;EFA02908.1;EEZ98813.2;EEZ97227.1;EFA06700.2;EFA08261.1;EFA09890.1;EFA03529.1;KYB25657.1;EFA08618.1;EFA07964.1;KYB28989.1;EFA02668.2;EEZ99208.1 Reactome: R-HSA-1650814 Collagen biosynthesis and modifying enzymes 8 EEZ97485.1;EFA04092.2;KYB28517.1;EFA00883.1;KYB27188.1;KYB25044.1;EEZ97484.1;EFA04342.1 Reactome: R-HSA-1483148 Synthesis of PG 7 EFA08139.1;EFA02113.2;EEZ99465.2;KYB27775.1;KYB24936.1;EFA13216.1;EEZ97194.1 Reactome: R-HSA-9603798 Class I peroxisomal membrane protein import 7 EFA04363.1;EFA02007.1;EFA10352.2;EFA04853.2;EFA06668.1;EFA05071.1;EFA00035.1 Reactome: R-HSA-74259 Purine catabolism 9 EFA06359.1;EFA06106.1;EFA03250.2;EEZ98343.1;EFA03919.1;KYB25712.1;EFA01001.1;KYB29062.1;EFA09973.1 KEGG: 00903+4.2.1.17 Limonene and pinene degradation 3 EFA08151.1;EFA05073.1;EFA04382.1 Reactome: R-HSA-9033241 Peroxisomal protein import 19 KYB28799.1;KYB29360.1;EFA00550.1;EEZ97738.1;EFA09569.1;EFA02110.1;EEZ97708.2;EFA11530.1;EFA09425.1;EFA04352.1;EFA10352.2;EFA04761.2;EEZ98651.1;KYB29057.1;EFA06668.1;EFA09724.1;KYB29359.1;KYB27725.1;EFA04853.2 MetaCyc: PWY-7807 Glyphosate degradation III 3 EEZ98942.2;EFA00136.2;EFA06669.1 KEGG: 00620+1.1.1.27 Pyruvate metabolism 1 EFA01008.1 Reactome: R-HSA-6782210 Gap-filling DNA repair synthesis and ligation in TC-NER 43 KYB25334.1;EFA12420.2;EFA12724.1;EFA09711.2;EFA07958.1;EFA07762.1;EFA03150.1;KYB26001.1;KYB25378.1;EFA05226.1;EFA02110.1;EFA06672.2;EFA07031.1;KYB29442.1;EFA10422.1;EFA12891.1;KYB28470.1;EFA00018.1;KYB29360.1;KYB29359.1;EFA05896.1;EFA00328.1;EFA06042.1;EFA03814.1;EFA02756.1;EFA06560.1;KYB28925.1;KYB26713.1;EFA03020.2;EFA07302.1;EFA07055.2;KYB25721.1;EFA02310.1;KYB26824.1;KYB28926.1;EFA08812.2;KYB27483.1;EFA08916.1;EFA09906.2;EEZ98905.1;KYB26826.1;KYB25740.1;EFA06469.1 Reactome: R-HSA-5389840 Mitochondrial translation elongation 61 KYB27767.1;KYB28774.1;EFA06988.1;EFA07649.2;EFA09578.1;EEZ97275.1;EFA02562.2;EFA02162.2;EFA03187.2;KYB24820.1;EFA03392.1;KYB27088.1;EFA10018.1;KYB26787.1;EFA04432.1;KYB28924.1;KYB29057.1;EFA03754.1;EFA00783.1;EFA08204.1;EFA07359.2;EFA06934.1;KYB28841.1;KYB26858.1;EFA06635.1;EEZ98800.1;EFA08827.1;EEZ98314.1;EFA06887.2;EFA06593.1;EFA07822.2;EFA04074.1;EFA02474.1;EFA01965.1;EFA01516.1;KYB25660.1;EFA00128.1;EFA01882.1;EEZ98621.2;EFA07281.1;EFA00920.1;EFA07911.1;KYB29134.1;EFA09638.1;EFA04773.2;EFA00323.1;EFA07188.1;EFA02054.1;KYB26079.1;EFA04077.1;EFA08456.1;EFA13662.2;EFA10137.1;EFA08795.1;EFA03160.1;KYB29135.1;EFA12135.2;KYB29220.1;EEZ99502.1;EFA11361.1;EFA10545.1 KEGG: 00230+1.17.4.1 Purine metabolism 3 EFA02202.1;EFA02203.1;EFA03825.1 KEGG: 00562+2.7.1.158 Inositol phosphate metabolism 2 KYB25213.1;EFA10622.1 MetaCyc: PWY-7035 (9Z)-tricosene biosynthesis 21 KYB29211.1;EFA00084.1;EFA05977.1;EFA03551.1;KYB25453.1;EFA00083.2;EFA03752.1;EFA09483.1;EFA09796.1;KYB25454.1;EFA05473.2;KYB25229.1;EFA05143.1;EFA10643.2;EEZ97311.1;EFA10641.2;EFA10642.1;EFA05474.1;KYB29213.1;EFA09795.1;KYB25455.1 Reactome: R-HSA-6791461 RPIA deficiency: failed conversion of RU5P to R5P 1 EFA01628.1 Reactome: R-HSA-6804115 TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain 7 KYB26978.1;KYB28664.1;EFA06281.1;EFA06380.2;EFA05098.1;EFA00624.1;EEZ99732.2 KEGG: 00860+1.16.3.1 Porphyrin and chlorophyll metabolism 1 EEZ97465.1 MetaCyc: PWY-7159 3,8-divinyl-chlorophyllide a biosynthesis III (aerobic, light independent) 3 KYB29726.1;EEZ98095.1;EEZ98060.1 Reactome: R-HSA-917977 Transferrin endocytosis and recycling 23 KYB29411.1;EFA11012.1;EEZ99208.1;EFA08618.1;EFA06225.1;EFA03371.1;EFA01142.2;EFA02476.1;KYB28989.1;KYB29412.1;EFA02241.1;EEZ98406.2;KYB29410.1;EFA05894.1;EEZ99071.2;EFA06700.2;EFA02242.2;EFA10717.1;EFA02908.1;KYB29409.1;EEZ98813.2;EEZ97227.1;KYB29413.1 KEGG: 00380+3.5.1.9 Tryptophan metabolism 1 KYB25672.1 KEGG: 00500+2.4.1.11 Starch and sucrose metabolism 1 EFA05468.1 KEGG: 00900+2.7.4.2 Terpenoid backbone biosynthesis 1 KYB29328.1 KEGG: 00270+3.1.3.77 Cysteine and methionine metabolism 1 EFA07663.1 MetaCyc: PWY-7396 Butanol and isobutanol biosynthesis (engineered) 1 EEZ98950.2 KEGG: 00430+2.3.2.2 Taurine and hypotaurine metabolism 4 KYB26172.1;EFA08906.2;KYB26171.1;EFA08621.1 KEGG: 00510+2.4.1.258 N-Glycan biosynthesis 1 EFA05490.1 Reactome: R-HSA-6803205 TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain 3 EFA12967.1;EFA12882.1;EFA12881.2 KEGG: 00240+3.6.1.9 Pyrimidine metabolism 2 EFA04414.1;EFA03919.1 Reactome: R-HSA-5218921 VEGFR2 mediated cell proliferation 4 KYB29732.1;EFA00152.1;EEZ97639.1;EFA11212.2 Reactome: R-HSA-5654693 FRS-mediated FGFR1 signaling 1 EFA09507.1 KEGG: 00380+1.14.16.4 Tryptophan metabolism 1 EFA01002.1 KEGG: 00550+2.4.1.227 Peptidoglycan biosynthesis 1 EEZ98644.1 Reactome: R-HSA-74217 Purine salvage 14 EFA01001.1;EFA07316.1;KYB26469.1;EFA00425.1;KYB25746.1;EFA00339.1;EFA07116.1;EFA08050.1;EFA06520.1;KYB25745.1;EFA03250.2;KYB26470.1;EFA06669.1;EFA06084.2 Reactome: R-HSA-71288 Creatine metabolism 3 KYB29642.1;EEZ99820.1;KYB25432.1 Reactome: R-HSA-5620924 Intraflagellar transport 10 EFA05121.1;KYB26892.1;EFA07590.1;EFA09915.1;EFA02064.2;EEZ97358.1;EFA00316.2;EFA01913.1;EFA06251.1;EFA11044.2 KEGG: 00591+1.14.14.1 Linoleic acid metabolism 1 EFA05733.1 Reactome: R-HSA-1482798 Acyl chain remodeling of CL 2 EFA06877.2;EFA04382.1 KEGG: 00620+6.4.1.2 Pyruvate metabolism 1 EFA05436.2 MetaCyc: PWY-2781 Cis-zeatin biosynthesis 1 EEZ99485.2 MetaCyc: PWY-7328 Superpathway of UDP-glucose-derived O-antigen building blocks biosynthesis 3 EFA06422.2;KYB26631.1;EFA06670.2 KEGG: 00720+6.4.1.3 Carbon fixation pathways in prokaryotes 1 EFA03463.2 Reactome: R-HSA-5676934 Protein repair 3 KYB27499.1;EFA03067.1;EFA08080.1 Reactome: R-HSA-68616 Assembly of the ORC complex at the origin of replication 7 EFA06929.1;EFA03157.1;KYB29174.1;EFA06374.2;EFA05162.2;EFA10460.1;EFA11188.2 KEGG: 00730+2.7.6.2 Thiamine metabolism 2 EEZ98443.2;KYB29167.1 MetaCyc: PWY-6308 L-cysteine biosynthesis II (tRNA-dependent) 3 EEZ99888.1;EEZ98713.1;EFA05626.1 KEGG: 00620+4.2.1.2 Pyruvate metabolism 1 EFA03144.1 MetaCyc: PWY-7802 N-end rule pathway II (prokaryotic) 1 EFA08318.1 MetaCyc: PWY-7573 GDP-mycosamine biosynthesis 1 EFA01082.1 KEGG: 00480+6.3.2.2 Glutathione metabolism 1 EFA04528.1 KEGG: 00592+1.3.3.6 alpha-Linolenic acid metabolism 3 EFA11530.1;EFA09425.1;EFA09569.1 Reactome: R-HSA-975144 IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation 6 KYB29359.1;EFA02110.1;KYB26671.1;KYB26669.1;EFA02851.1;KYB29360.1 MetaCyc: PWY-2161B Glutamate removal from folates 2 EFA00210.2;KYB28918.1 Reactome: R-HSA-110330 Recognition and association of DNA glycosylase with site containing an affected purine 4 EFA06198.1;EFA00785.1;EEZ98702.1;KYB24563.1 KEGG: 00860+1.3.3.4 Porphyrin and chlorophyll metabolism 1 EEZ98095.1 Reactome: R-HSA-379726 Mitochondrial tRNA aminoacylation 13 EEZ99471.1;KYB27531.1;EFA03776.2;EFA03147.2;EFA04272.1;EEZ98764.2;EFA03680.2;KYB26719.1;EFA03333.2;EFA12136.2;EFA00333.1;KYB27572.1;EFA07176.1 KEGG: 00240+6.3.4.2 Pyrimidine metabolism 2 KYB28254.1;EEZ99788.2 Reactome: R-HSA-4641265 Repression of WNT target genes 9 KYB28559.1;KYB28977.1;EFA10253.2;KYB29349.1;KYB28557.1;EEZ99317.2;KYB28558.1;KYB28976.1;KYB28556.1 Reactome: R-HSA-456926 Thrombin signalling through proteinase activated receptors (PARs) 6 KYB29172.1;KYB25344.1;EFA08973.1;KYB25864.1;EFA10708.1;EEZ98203.2 Reactome: R-HSA-5693607 Processing of DNA double-strand break ends 33 KYB26388.1;EFA02756.1;EFA11787.2;EFA13005.2;KYB29359.1;EEZ99220.1;KYB25791.1;KYB25740.1;EFA05681.1;EFA09906.2;EFA08916.1;KYB27777.1;KYB27483.1;EEZ99558.2;EFA10575.1;EFA08981.1;EFA02661.1;EEZ97797.2;EFA09584.2;EFA04934.2;EFA09711.2;EFA12420.2;EFA05870.2;EFA07487.1;KYB29360.1;EFA04644.2;KYB24996.1;EFA12891.1;EFA04568.2;KYB24563.1;EEZ97760.2;EEZ97345.1;EFA02110.1 Reactome: R-HSA-420499 Class C/3 (Metabotropic glutamate/pheromone receptors) 9 EFA11457.2;EFA11126.2;KYB25636.1;KYB25635.1;EFA01604.1;EEZ98591.1;KYB25638.1;KYB25637.1;EFA03560.2 Reactome: R-HSA-9633012 Response of EIF2AK4 (GCN2) to amino acid deficiency 78 EFA03533.1;EFA02992.1;EFA00935.2;EEZ97412.1;EEZ97313.1;EFA06382.1;EFA10201.2;EFA08054.1;EFA02110.1;EFA11837.1;EFA08168.1;EFA08849.1;EFA00505.1;EFA07030.1;EFA05867.1;EFA01805.1;KYB29359.1;EFA04453.1;EFA02145.1;KYB27475.1;EEZ97379.1;EFA06534.1;EFA05170.2;EFA07164.1;EFA03346.1;EFA02268.1;EEZ99099.1;EFA07141.1;EFA04946.1;EFA09067.1;EFA01731.1;EEZ98728.1;EFA13254.1;EFA09212.1;EFA06341.1;EFA08624.1;EFA06574.1;KYB27567.1;KYB27801.1;KYB26424.1;EFA11293.1;EFA04159.1;EFA09970.1;KYB29621.1;EEZ99023.1;EFA06330.1;EFA05373.1;EFA03478.1;EFA03441.1;EFA09345.2;EEZ98858.1;KYB27741.1;EEZ98503.1;EFA02257.1;EFA03236.1;EFA11360.1;EFA10462.1;KYB29360.1;EFA02592.1;EFA10173.2;EFA05803.1;EFA10183.1;EEZ97360.2;EFA01765.1;EFA04120.1;EFA05471.1;EFA00163.1;EFA12204.1;EEZ97645.1;KYB27481.1;EFA00826.2;EFA01051.1;EFA02554.1;EFA09390.1;EFA10969.1;EEZ98852.1;EFA03166.1;EFA07317.1 KEGG: 00760+2.3.1.286 Nicotinate and nicotinamide metabolism 6 EEZ98502.1;EFA12149.1;EFA06770.1;KYB26875.1;EFA11222.2;EEZ99804.1 Reactome: R-HSA-2151209 Activation of PPARGC1A (PGC-1alpha) by phosphorylation 1 EFA02004.1 Reactome: R-HSA-3299685 Detoxification of Reactive Oxygen Species 27 EEZ99483.1;KYB28799.1;EFA10733.1;EEZ97738.1;EEZ99271.1;EFA09191.1;EFA02790.1;EFA10684.1;EFA02019.1;EFA05230.1;EFA01361.1;EFA11546.1;EEZ97708.2;KYB26853.1;EFA01372.1;EFA10695.2;EFA01369.1;EFA01370.1;EFA05664.1;EFA04630.1;KYB25410.1;EFA10685.2;EFA07539.1;KYB27349.1;EFA08214.1;EEZ99359.1;KYB27348.1 Reactome: R-HSA-174362 Transport and synthesis of PAPS 1 EFA13134.1 Reactome: R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding 17 EFA02141.1;KYB25864.1;EEZ98476.1;KYB25253.1;EEZ98580.1;EEZ97857.1;EEZ98562.1;EFA11094.1;KYB25254.1;EEZ97852.2;EEZ99111.1;EFA10835.1;EFA02100.1;EFA04253.1;EFA06459.1;EFA10303.2;EFA05810.1 MetaCyc: PWY-7036 Very long chain fatty acid biosynthesis II 21 KYB29211.1;EFA00084.1;EFA05977.1;EFA03551.1;KYB25453.1;EFA03752.1;EFA00083.2;EFA09483.1;KYB25454.1;EFA09796.1;EFA05473.2;KYB25229.1;EFA10643.2;EFA05143.1;EEZ97311.1;EFA10641.2;EFA10642.1;EFA05474.1;EFA09795.1;KYB29213.1;KYB25455.1 Reactome: R-HSA-901042 Calnexin/calreticulin cycle 1 EEZ98119.2 MetaCyc: PWY-2261 Ascorbate glutathione cycle 3 EEZ99479.1;EEZ99480.1;EFA00963.1 KEGG: 00510+3.2.1.106 N-Glycan biosynthesis 1 KYB25099.1 MetaCyc: PWY-6627 Salinosporamide A biosynthesis 2 EFA03250.2;EFA01001.1 MetaCyc: PWY-4041 Gamma-glutamyl cycle 4 KYB26172.1;KYB26171.1;EFA08906.2;EFA08621.1 MetaCyc: PWY-6788 Cellulose degradation II (fungi) 1 KYB27092.1 KEGG: 00620+1.2.4.1 Pyruvate metabolism 2 EFA00132.1;EFA00070.1 KEGG: 00680+2.7.1.11 Methane metabolism 2 KYB26002.1;EFA08228.2 Reactome: R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein 19 EFA11447.2;EEZ97868.2;EFA03584.1;EFA00581.2;EFA05993.1;EFA00605.1;EFA09537.1;EFA11141.2;KYB29624.1;EFA04928.2;KYB28630.1;EEZ98695.2;EFA01249.2;EFA01782.2;KYB28401.1;EFA03859.1;EFA07823.1;KYB29271.1;KYB29364.1 KEGG: 00232+1.14.14.1 Caffeine metabolism 1 EFA05733.1 Reactome: R-HSA-182218 Nef Mediated CD8 Down-regulation 3 EFA08618.1;EFA11263.1;EFA09781.1 KEGG: 00500+2.7.1.1 Starch and sucrose metabolism 4 EEZ97931.1;KYB29370.1;EEZ97932.2;KYB29371.1 Reactome: R-HSA-180746 Nuclear import of Rev protein 20 EFA03859.1;KYB28401.1;EFA01249.2;EFA01782.2;KYB29364.1;EFA07823.1;KYB29271.1;EFA04928.2;EEZ98695.2;KYB28630.1;EFA00605.1;EFA05993.1;KYB29624.1;EFA09537.1;EFA11141.2;EFA10538.1;EEZ97868.2;EFA11447.2;EFA00581.2;EFA03584.1 Reactome: R-HSA-4615885 SUMOylation of DNA replication proteins 23 EFA01344.2;EEZ97868.2;EFA11447.2;EFA03584.1;EFA07677.2;EFA00581.2;EFA05993.1;EFA00605.1;EFA00171.1;EFA09537.1;EFA11141.2;KYB29624.1;EFA04928.2;KYB28630.1;EEZ98695.2;EFA01782.2;EFA01249.2;KYB28401.1;EFA03859.1;EFA07823.1;KYB29271.1;EFA06042.1;KYB29364.1 MetaCyc: PWY-5667 CDP-diacylglycerol biosynthesis I 14 KYB29132.1;KYB29133.1;EEZ97656.1;EFA09975.1;KYB27110.1;EFA03942.2;EFA02132.1;EEZ97257.1;EFA04525.1;EFA04759.2;EFA04441.1;EFA06119.2;KYB27111.1;EEZ98249.2 KEGG: 00260+2.1.2.1 Glycine, serine and threonine metabolism 1 EFA09131.1 KEGG: 00680+4.2.1.11 Methane metabolism 3 EFA09610.1;EFA10506.1;EFA09609.1 KEGG: 00240+2.7.4.6 Pyrimidine metabolism 5 EFA03917.1;EEZ98594.1;KYB26165.1;EEZ99726.1;EFA07171.1 Reactome: R-HSA-167200 Formation of HIV-1 elongation complex containing HIV-1 Tat 30 EFA06469.1;EFA00018.1;KYB28470.1;EEZ97398.2;EFA00603.1;EFA00606.1;EFA07031.1;EFA12997.1;EEZ98144.2;EEZ98143.1;EFA02310.1;EFA04061.1;EFA10288.1;EFA07055.2;EFA07302.1;KYB25152.1;EFA05226.1;KYB25378.1;KYB26001.1;EFA06560.1;EFA10605.2;EFA08590.1;EFA03550.1;EFA03150.1;EFA00397.1;EFA07148.1;EFA00328.1;EFA05896.1;EFA05446.1;KYB25207.1 Reactome: R-HSA-5683371 Defective ABCB6 causes isolated colobomatous microphthalmia 7 (MCOPCB7) 1 EFA05094.1 MetaCyc: PWY-3162 L-tryptophan degradation V (side chain pathway) 1 EEZ98950.2 KEGG: 00010+1.1.1.27 Glycolysis / Gluconeogenesis 1 EFA01008.1 MetaCyc: PWY-5078 L-isoleucine degradation II 2 EEZ98004.1;EEZ98950.2 Reactome: R-HSA-5607761 Dectin-1 mediated noncanonical NF-kB signaling 43 KYB27557.1;KYB29360.1;EEZ99493.1;EFA13218.1;EFA02345.1;EFA08911.2;EFA02110.1;EFA06741.1;EFA06519.1;EFA11079.1;EFA08664.1;EEZ99274.1;EFA06200.1;KYB27556.1;EEZ97876.1;EFA03341.1;KYB26764.1;EFA02847.1;EFA09518.2;EFA07659.2;EFA05871.2;EFA08601.1;EFA05105.1;EFA03019.1;EFA02331.1;EEZ98185.1;EFA07261.2;EEZ97564.1;EFA08798.1;EFA09524.2;EFA05865.1;EFA04054.1;KYB24713.1;EEZ99004.1;EFA05833.1;EFA05370.2;KYB25309.1;EFA04284.1;EFA11744.1;KYB26545.1;EFA07110.1;KYB29359.1;EFA05912.1 Reactome: R-HSA-1295596 Spry regulation of FGF signaling 4 KYB29360.1;EFA10708.1;EFA02110.1;KYB29359.1 KEGG: 00290+2.6.1.42 Valine, leucine and isoleucine biosynthesis 1 EEZ98004.1 KEGG: 00513+2.4.1.258 Various types of N-glycan biosynthesis 1 EFA05490.1 Reactome: R-HSA-983695 Antigen activates B Cell Receptor (BCR) leading to generation of second messengers 2 EFA11212.2;KYB29732.1 KEGG: 00280+1.3.8.4 Valine, leucine and isoleucine degradation 1 EFA04754.2 KEGG: 00670+2.1.2.1 One carbon pool by folate 1 EFA09131.1 MetaCyc: PWY-7783 Plasmalogen degradation 23 KYB27219.1;EFA11812.1;EFA12460.1;KYB27221.1;KYB26689.1;KYB29358.1;EFA08691.1;EFA13468.1;EFA07968.1;EFA03430.2;KYB27220.1;EFA12193.1;EFA12278.1;EFA09107.1;EFA05083.2;EFA09487.1;EEZ99784.2;EFA12575.1;EFA07860.2;KXZ75683.1;EFA13680.1;EEZ98801.1;EFA12309.1 KEGG: 00790+1.14.16.4 Folate biosynthesis 1 EFA01002.1 Reactome: R-HSA-3134963 DEx/H-box helicases activate type I IFN and inflammatory cytokines production 1 EFA01304.1 Reactome: R-HSA-381183 ATF6 (ATF6-alpha) activates chaperone genes 3 EEZ98819.2;EFA09953.1;EFA01850.1 KEGG: 00230+4.6.1.2 Purine metabolism 9 EFA02701.2;KYB25768.1;EFA07684.2;KYB27920.1;EEZ98124.2;EFA02348.1;EFA09532.2;KYB25441.1;EFA01870.2 MetaCyc: PWY-6703 Preq0 biosynthesis 1 EFA13034.1 Reactome: R-HSA-390450 Folding of actin by CCT/TriC 8 EEZ98476.1;EEZ97857.1;EFA02100.1;EEZ99111.1;EFA02141.1;EEZ98562.1;EFA05810.1;EFA06459.1 KEGG: 04151+2.7.1.153 PI3K-Akt signaling pathway 1 EFA09848.2 MetaCyc: PWY-5497 Purine nucleobases degradation II (anaerobic) 5 EFA06106.1;EFA09131.1;EFA09973.1;EFA07236.1;EFA07809.2 Reactome: R-HSA-8963684 Tyrosine catabolism 4 EFA07806.1;EFA06896.1;EFA03251.1;EFA06443.1 Reactome: R-HSA-1251985 Nuclear signaling by ERBB4 6 EFA04103.1;KYB29228.1;EFA05049.2;EEZ98535.2;EFA07178.2;KYB27078.1 Reactome: R-HSA-445355 Smooth Muscle Contraction 10 KYB24968.1;EFA02701.2;KYB24970.1;KYB27920.1;KYB24967.1;EEZ97595.2;EEZ98124.2;EFA02348.1;EFA01870.2;KYB24969.1 MetaCyc: PWY-7909 Formaldehyde oxidation VII (THF pathway) 2 EFA07236.1;EFA07809.2 KEGG: 00910+6.3.1.2 Nitrogen metabolism 2 EEZ99821.1;EEZ97848.1 Reactome: R-HSA-388479 Vasopressin-like receptors 4 EFA07580.2;KYB27541.1;EFA04640.2;EFA09262.1 MetaCyc: PWY-7394 Urate conversion to allantoin II 3 EEZ99723.1;KYB28295.1;EFA02262.1 MetaCyc: PWY-6596 Adenosine nucleotides degradation I 6 EFA11857.1;EFA06084.2;EFA09973.1;KYB26469.1;EFA01792.1;KYB26470.1 KEGG: 00592+3.1.1.4 alpha-Linolenic acid metabolism 23 EFA12193.1;KYB27220.1;EFA03430.2;EFA05083.2;EFA09107.1;EFA12278.1;EFA08691.1;EFA13468.1;EFA07968.1;EEZ98801.1;EFA13680.1;EFA12309.1;EFA09487.1;KXZ75683.1;EFA12575.1;EFA07860.2;EEZ99784.2;EFA11812.1;KYB27219.1;KYB29358.1;EFA12460.1;KYB27221.1;KYB26689.1 MetaCyc: PWY-7663 Gondoate biosynthesis (anaerobic) 7 EFA05203.2;EFA05201.1;EFA05249.2;EFA05204.2;EFA11365.1;EEZ97866.2;EFA05248.1 Reactome: R-HSA-70635 Urea cycle 3 EFA11668.2;EEZ97516.1;EFA03145.1 KEGG: 00970+6.1.1.17 Aminoacyl-tRNA biosynthesis 3 EFA03776.2;KYB27531.1;KYB26720.1 KEGG: 00281+4.2.1.17+1.1.1.35 Geraniol degradation 3 EFA05073.1;EFA08151.1;EFA04382.1 Reactome: R-HSA-9649948 Signaling downstream of RAS mutants 6 EEZ99807.2;EFA10708.1;KYB26173.1;EFA08276.1;KYB28360.1;EFA05346.2 MetaCyc: PWY-7187 Pyrimidine deoxyribonucleotides de novo biosynthesis II 11 EFA03917.1;EFA11748.1;EFA04414.1;EFA03919.1;EEZ99726.1;EFA00847.2;EFA02095.1;EFA08206.2;EEZ98594.1;EFA07171.1;KYB26165.1 KEGG: 04070+2.7.1.150 Phosphatidylinositol signaling system 1 EFA00380.1 Reactome: R-HSA-4551295 Defective ALG11 causes ALG11-CDG (CDG-1p) 1 EFA05431.1 Reactome: R-HSA-6804757 Regulation of TP53 Degradation 10 KYB29360.1;EFA10417.1;EFA00152.1;EFA11787.2;EFA07964.1;EFA02105.1;EFA07762.1;EEZ99088.1;EFA02110.1;KYB29359.1 MetaCyc: PWY-1042 Glycolysis IV (plant cytosol) 17 KYB24934.1;KYB24935.1;EFA08228.2;EEZ99016.2;EFA07763.1;EFA08842.1;EFA10506.1;EFA09609.1;EFA08832.2;KYB26002.1;KYB25941.1;EFA04932.1;EFA09610.1;EEZ97193.2;EFA05374.1;EFA08517.1;EFA01748.1 KEGG: 04926+2.7.11.1 Relaxin signaling pathway 55 EEZ98563.1;KYB25762.1;EFA13584.2;KYB27402.1;EFA08613.1;KYB28374.1;KYB28438.1;EFA11019.1;EEZ99162.2;KYB28836.1;KYB28439.1;KYB29263.1;EFA11184.1;EFA04100.2;EFA02123.1;EFA07902.1;KYB26173.1;EFA06330.1;KYB27919.1;EFA05002.2;EFA00691.2;EFA11391.2;EFA00805.1;EFA00476.1;EFA10912.2;EFA00152.1;EFA10048.1;EFA08276.1;EFA07752.1;EFA00769.1;EFA08636.2;EFA11394.1;KYB27979.1;KYB28376.1;EFA01876.2;KYB28375.1;KYB28377.1;KYB27138.1;EFA05720.1;KYB28437.1;EFA07410.1;KYB28837.1;KYB27978.1;EEZ99828.2;KYB25791.1;EFA04406.2;EFA10720.1;EFA02342.2;EEZ97987.1;KYB29873.1;EFA11787.2;EEZ98574.2;EFA03058.1;EFA02105.1;EFA07964.1 MetaCyc: PWY-4321 L-glutamate degradation IV 2 KYB25522.1;KYB25521.1 MetaCyc: PWY-8040 Ansatrienin biosynthesis 1 EFA09643.1 KEGG: 00513+3.2.1.52 Various types of N-glycan biosynthesis 10 EFA08995.1;KYB25657.1;EFA06836.2;EFA05959.1;EFA11380.2;EFA07069.1;EFA06863.2;EFA05960.2;EEZ98597.1;EFA10268.1 Reactome: R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere 6 EFA13202.2;EFA09410.1;EFA06856.2;KYB24696.1;KYB24563.1;KYB24697.1 Reactome: R-HSA-162791 Attachment of GPI anchor to uPAR 6 EFA06039.1;EFA04314.1;KYB26647.1;EFA08175.1;EFA03225.1;EFA07117.1 KEGG: 00230+3.1.4.53 Purine metabolism 3 EFA10768.1;KYB25288.1;KYB25286.1 KEGG: 00520+5.4.2.3 Amino sugar and nucleotide sugar metabolism 1 EFA09778.2 Reactome: R-HSA-1170546 Prolactin receptor signaling 3 EFA02847.1;KYB27132.1;EFA05273.2 KEGG: 00240+1.17.4.1 Pyrimidine metabolism 3 EFA02202.1;EFA02203.1;EFA03825.1 KEGG: 00521+2.7.1.1 Streptomycin biosynthesis 4 KYB29370.1;EEZ97932.2;EEZ97931.1;KYB29371.1 KEGG: 00240+4.2.1.70 Pyrimidine metabolism 1 EFA03366.1 KEGG: 00520+4.2.1.47 Amino sugar and nucleotide sugar metabolism 1 EFA01082.1 Reactome: R-HSA-9617629 Regulation of FOXO transcriptional activity by acetylation 1 EFA02517.2 KEGG: 00515+2.4.1.109 Mannose type O-glycan biosynthesis 7 KYB26307.1;EFA03006.2;KYB27853.1;KYB27854.1;EEZ97998.1;EFA01829.1;EFA04002.2 KEGG: 00140+1.14.14.1 Steroid hormone biosynthesis 1 EFA05733.1 MetaCyc: PWY-6824 Justicidin B biosynthesis 1 EFA01243.1 Reactome: R-HSA-2559582 Senescence-Associated Secretory Phenotype (SASP) 17 KYB27187.1;EFA00073.1;KYB29359.1;EEZ97189.1;EFA01569.1;KYB25814.1;EEZ98737.1;EFA01854.1;EFA04231.1;EFA10708.1;EFA02110.1;KYB27271.1;EEZ99272.2;EEZ97989.1;KYB24563.1;EEZ98849.2;KYB29360.1 Reactome: R-HSA-1221632 Meiotic synapsis 4 KYB24563.1;KYB25791.1;EEZ97230.1;EEZ98702.1 MetaCyc: PWY-7347 Sucrose biosynthesis III 1 EFA07687.2 MetaCyc: PWY-7343 UDP-alpha-D-glucose biosynthesis I 1 EFA06874.2 MetaCyc: PWY-6749 CMP-legionaminate biosynthesis I 5 KYB25938.1;KYB28361.1;EFA09778.2;EFA10132.1;EEZ99805.2 KEGG: 00720+4.2.1.2 Carbon fixation pathways in prokaryotes 1 EFA03144.1 MetaCyc: PWY-5386 Methylglyoxal degradation I 2 EFA08581.1;EFA05578.1 KEGG: 00030+3.1.1.17 Pentose phosphate pathway 2 EFA10016.2;EFA03133.1 Reactome: R-HSA-164843 2-LTR circle formation 3 EFA03479.1;KYB26425.1;EFA07537.1 Reactome: R-HSA-163210 Formation of ATP by chemiosmotic coupling 12 EFA05714.1;EFA07499.1;EFA07449.2;EEZ99347.1;EFA07448.1;EFA07428.1;EFA01349.1;EFA04639.1;EFA09167.1;EFA07467.2;EEZ97751.1;EEZ99200.1 KEGG: 00720+4.2.1.17+1.1.1.35 Carbon fixation pathways in prokaryotes 3 EFA04382.1;EFA08151.1;EFA05073.1 Reactome: R-HSA-211733 Regulation of activated PAK-2p34 by proteasome mediated degradation 40 EFA06741.1;EFA06519.1;EFA11079.1;EFA08664.1;EFA06200.1;KYB27556.1;EEZ97876.1;EFA03341.1;KYB26764.1;KYB27557.1;KYB29360.1;EEZ99493.1;EFA13218.1;EFA02345.1;EFA08911.2;EFA02110.1;KYB24713.1;EFA05833.1;EEZ99004.1;EFA05370.2;EFA04284.1;KYB25309.1;KYB26545.1;EFA07110.1;KYB29359.1;EFA05912.1;EFA09518.2;EFA07659.2;EFA05871.2;EFA08601.1;EFA05105.1;EFA03019.1;EFA02331.1;EEZ98185.1;EFA07261.2;EEZ97564.1;EFA08798.1;EFA09524.2;EFA05865.1;EFA04054.1 Reactome: R-HSA-1538133 G0 and Early G1 3 EFA01741.1;EFA08856.2;EFA02434.1 Reactome: R-HSA-399719 Trafficking of AMPA receptors 4 KYB29108.1;KYB28360.1;EEZ98246.1;EEZ99807.2 Reactome: R-HSA-6802953 RAS signaling downstream of NF1 loss-of-function variants 1 EFA01244.2 Reactome: R-HSA-1482788 Acyl chain remodelling of PC 9 KYB29358.1;EEZ98801.1;EEZ99784.2;KYB27221.1;EFA05083.2;EFA03430.2;KYB27220.1;EFA08691.1;KYB27219.1 Reactome: R-HSA-69601 Ubiquitin Mediated Degradation of Phosphorylated Cdc25A 40 EFA05865.1;EFA04054.1;EFA08798.1;EFA09524.2;EFA07261.2;EEZ97564.1;EEZ98185.1;EFA02331.1;EFA05105.1;EFA03019.1;EFA08601.1;EFA09518.2;EFA05871.2;EFA07659.2;EFA05912.1;KYB29359.1;EFA07110.1;KYB26545.1;EFA04284.1;KYB25309.1;EFA05370.2;KYB24713.1;EFA05833.1;EEZ99004.1;EFA02110.1;EFA02345.1;EFA13218.1;EFA08911.2;EEZ99493.1;KYB29360.1;KYB27557.1;EFA03341.1;KYB26764.1;EEZ97876.1;KYB27556.1;EFA06200.1;EFA08664.1;EFA06519.1;EFA11079.1;EFA06741.1 Reactome: R-HSA-1989781 PPARA activates gene expression 41 EEZ97247.1;EFA12821.2;KYB27676.1;KYB27096.1;EFA10996.1;EFA02633.1;EEZ98716.2;EFA08543.1;EFA09953.1;EFA00809.1;EFA02017.1;EFA00806.2;KYB29566.1;EFA08558.1;KYB26838.1;EFA06304.1;EFA03598.1;KYB29567.1;KYB28595.1;EFA09949.2;EFA03597.1;EFA06850.2;EFA03097.1;EFA09832.1;KYB28596.1;EFA01132.1;EFA00475.1;EFA07012.2;EFA02517.2;EFA01136.1;EFA01959.1;EFA01850.1;EFA07303.1;EFA00114.1;EFA06636.1;EFA04179.1;EFA00473.1;EFA04844.1;EFA06894.2;EEZ97239.1;KYB25781.1 Reactome: R-HSA-73863 RNA Polymerase I Transcription Termination 16 KYB28470.1;EFA00018.1;EFA06469.1;EFA07031.1;EFA07284.1;EEZ99110.1;EFA08638.2;EFA07302.1;EFA02310.1;KYB26622.1;EFA07055.2;KYB25378.1;EFA03150.1;KYB26001.1;EFA00328.1;EFA05896.1 MetaCyc: PWY-6644 Fluoroacetate and fluorothreonine biosynthesis 2 EFA01001.1;EFA03250.2 Reactome: R-HSA-5419276 Mitochondrial translation termination 58 EFA01965.1;EFA06593.1;EEZ98314.1;EFA02474.1;EFA04074.1;EFA07822.2;KYB29134.1;EEZ98621.2;EFA07911.1;EFA00920.1;EFA07281.1;EFA09638.1;EFA01516.1;KYB25660.1;EFA00128.1;EFA01882.1;EFA08456.1;EFA04077.1;KYB26079.1;EEZ98734.1;EFA13662.2;EFA07188.1;EFA00323.1;EFA02054.1;KYB29135.1;EFA03160.1;EEZ99502.1;EFA11361.1;EFA10545.1;KYB29220.1;EFA12135.2;EFA10137.1;EFA08795.1;EFA07649.2;EFA06988.1;EEZ97275.1;KYB28774.1;KYB27767.1;KYB27088.1;EFA03392.1;EFA10018.1;EFA02562.2;KYB24820.1;EFA02162.2;EFA03754.1;EFA00783.1;KYB29057.1;EFA07359.2;EFA06934.1;EFA08204.1;EFA04432.1;KYB26787.1;KYB28924.1;EFA08827.1;KYB26858.1;KYB28841.1;EEZ98800.1;EFA06635.1 Reactome: R-HSA-162588 Budding and maturation of HIV virion 9 EEZ97653.2;EEZ99668.1;EFA03761.1;KYB29360.1;EFA03831.1;EFA04908.1;EFA02110.1;KYB29359.1;EFA07193.1 Reactome: R-HSA-5668541 TNFR2 non-canonical NF-kB pathway 40 KYB26545.1;KYB29359.1;EFA05912.1;EFA07110.1;KYB24713.1;EEZ99004.1;EFA05833.1;KYB25309.1;EFA04284.1;EFA05370.2;EFA07261.2;EEZ97564.1;EFA05865.1;EFA04054.1;EFA08798.1;EFA09524.2;EFA08601.1;EFA09518.2;EFA05871.2;EFA07659.2;EEZ98185.1;EFA02331.1;EFA05105.1;EFA03019.1;EEZ97876.1;KYB27556.1;EFA03341.1;KYB26764.1;EFA06519.1;EFA11079.1;EFA06741.1;EFA06200.1;EFA08664.1;EFA02110.1;KYB29360.1;KYB27557.1;EFA02345.1;EFA13218.1;EFA08911.2;EEZ99493.1 MetaCyc: PWY-5895 Menaquinol-13 biosynthesis 2 EFA05173.2;KYB27131.1 Reactome: R-HSA-5663213 RHO GTPases Activate WASPs and WAVEs 9 KYB25950.1;EFA03329.2;EFA03253.1;EFA10708.1;EFA05342.1;EFA10974.1;EFA09668.1;EFA13274.1;EFA05486.1 Reactome: R-HSA-174414 Processive synthesis on the C-strand of the telomere 5 EFA07958.1;KYB28925.1;EFA06042.1;KYB25721.1;KYB28926.1 Reactome: R-HSA-373752 Netrin-1 signaling 1 EFA07528.2 Reactome: R-HSA-2173795 Downregulation of SMAD2/3:SMAD4 transcriptional activity 4 EFA02110.1;KYB29359.1;EFA00829.2;KYB29360.1 MetaCyc: PWY-5469 Sesamin biosynthesis 1 EFA01243.1 Reactome: R-HSA-1475029 Reversible hydration of carbon dioxide 4 EFA00432.1;EEZ98484.1;EFA11790.2;KYB29101.1 Reactome: R-HSA-5632684 Hedgehog 'on' state 44 EFA08601.1;EFA09518.2;EFA07659.2;EFA05871.2;EFA02331.1;EEZ98185.1;EFA05105.1;EFA03019.1;EFA07261.2;EEZ97564.1;EFA05865.1;EFA04054.1;EFA08798.1;EFA09524.2;EEZ97432.2;KYB24713.1;KYB29272.1;EFA05833.1;EEZ99004.1;EFA04284.1;KYB25309.1;EFA05370.2;KYB26545.1;EFA05912.1;KYB29359.1;EFA07110.1;KYB29360.1;EFA09161.1;KYB27557.1;EFA13218.1;EFA02345.1;EFA08911.2;EEZ99493.1;EFA02110.1;EFA06519.1;EFA11079.1;EFA06741.1;EFA06200.1;EFA08664.1;KYB27556.1;EEZ97876.1;EFA03341.1;KYB28973.1;KYB26764.1 Reactome: R-HSA-167158 Formation of the HIV-1 Early Elongation Complex 27 EFA00328.1;EFA07148.1;EFA00397.1;KYB25207.1;EFA05446.1;EFA05896.1;KYB25378.1;EFA05226.1;KYB25152.1;EFA03150.1;EFA08590.1;EFA03550.1;KYB26001.1;EFA06560.1;EEZ98144.2;EEZ98143.1;EFA07302.1;EFA10288.1;EFA07055.2;EFA02310.1;EFA00018.1;KYB28470.1;EFA06469.1;EFA07031.1;EFA00606.1;EFA00603.1;EEZ97398.2 KEGG: 00280+1.1.1.31 Valine, leucine and isoleucine degradation 1 EFA06587.2 MetaCyc: PWY-6535 4-aminobutanoate degradation I 2 KYB25522.1;KYB25521.1 Reactome: R-HSA-196299 Beta-catenin phosphorylation cascade 4 EFA13272.2;KYB26642.1;KYB26383.1;EFA05992.2 MetaCyc: PWY-181 Photorespiration 1 EFA09131.1 KEGG: 00030+2.2.1.2 Pentose phosphate pathway 1 EEZ98187.1 MetaCyc: PWY-7717 3-hydroxy-4-methyl-anthranilate biosynthesis I 2 EEZ98408.1;KYB25672.1 KEGG: 00561+2.7.1.107 Glycerolipid metabolism 11 KYB29061.1;EEZ98328.2;KYB29047.1;KYB29049.1;KYB26618.1;KYB26617.1;EFA03802.2;KYB29048.1;KYB25925.1;KYB29060.1;EFA08801.2 MetaCyc: PWY-6482 Diphthamide biosynthesis I (archaea) 3 EEZ99477.1;EFA02050.1;EFA05560.1 MetaCyc: PWY-8060 2-deoxy-D-ribose degradation I 1 EFA12496.1 KEGG: 00565+3.1.1.4 Ether lipid metabolism 23 KYB27221.1;KYB26689.1;EFA12460.1;KYB29358.1;KYB27219.1;EFA11812.1;EFA12575.1;KXZ75683.1;EFA07860.2;EEZ99784.2;EFA09487.1;EFA12309.1;EFA13680.1;EEZ98801.1;EFA07968.1;EFA13468.1;EFA08691.1;EFA05083.2;EFA09107.1;EFA12278.1;KYB27220.1;EFA12193.1;EFA03430.2 Reactome: R-HSA-422356 Regulation of insulin secretion 2 EFA11212.2;KYB29732.1 Reactome: R-HSA-2470946 Cohesin Loading onto Chromatin 6 KYB29713.1;EFA11119.1;EFA06737.1;EEZ99030.1;EEZ97230.1;EEZ99210.2 Reactome: R-HSA-975155 MyD88 dependent cascade initiated on endosome 2 EFA01304.1;EFA02851.1 Reactome: R-HSA-2408550 Metabolism of ingested H2SeO4 and H2SeO3 into H2Se 1 EFA13134.1 KEGG: 00362+4.2.1.17 Benzoate degradation 1 EFA04382.1 KEGG: 00520+2.7.7.12 Amino sugar and nucleotide sugar metabolism 1 KYB28384.1 KEGG: 00564+2.3.1.51 Glycerophospholipid metabolism 6 EFA04525.1;KYB27111.1;EEZ97257.1;EFA02132.1;KYB27110.1;EEZ97656.1 Reactome: R-HSA-166058 MyD88:MAL(TIRAP) cascade initiated on plasma membrane 3 EFA02851.1;EFA07356.1;EFA01304.1 Reactome: R-HSA-216083 Integrin cell surface interactions 11 EFA04092.2;EFA10689.2;EFA09341.2;KYB28696.1;EFA09738.2;EFA03618.2;EFA08161.2;KYB26399.1;KYB27188.1;KYB25676.1;KYB28697.1 Reactome: R-HSA-165158 Activation of AKT2 1 EFA00152.1 Reactome: R-HSA-196783 Coenzyme A biosynthesis 4 KYB29463.1;EEZ97196.1;KYB29462.1;EFA13040.1 Reactome: R-HSA-114508 Effects of PIP2 hydrolysis 15 KYB26618.1;EFA11212.2;KYB26617.1;EFA07407.1;KYB29049.1;KYB29047.1;EEZ98328.2;KYB29061.1;KYB29732.1;EFA07406.1;EFA08801.2;KYB29060.1;KYB25925.1;EFA03802.2;KYB29048.1 KEGG: 00500+3.2.1.1 Starch and sucrose metabolism 6 EEZ98450.1;KYB29170.1;KYB29169.1;EEZ98206.2;EEZ98454.1;EEZ98451.1 KEGG: 00520+5.4.2.8 Amino sugar and nucleotide sugar metabolism 1 EFA07975.2 KEGG: 00562+3.1.3.25 Inositol phosphate metabolism 2 EFA12936.1;KYB25020.1 Reactome: R-HSA-1250196 SHC1 events in ERBB2 signaling 3 EFA07406.1;EFA07407.1;EFA01355.2 Reactome: R-HSA-163560 Triglyceride catabolism 8 KYB28159.1;KYB27758.1;EFA02512.1;KYB27335.1;KYB27757.1;EFA04316.2;EFA02685.2;EFA05189.1 KEGG: 00220+1.14.13.39 Arginine biosynthesis 2 EFA10400.2;KYB25321.1 Reactome: R-HSA-381676 Glucagon-like Peptide-1 (GLP1) regulates insulin secretion 7 EFA06381.2;KYB29732.1;KYB26602.1;KYB28779.1;EEZ99469.1;EFA11212.2;KYB25864.1 MetaCyc: PWY-5743 3-hydroxypropanoate cycle 9 EFA04508.1;EFA11790.2;EFA07129.2;EFA03463.2;EFA03586.1;EFA00432.1;KYB29101.1;EFA05436.2;EEZ98484.1 Reactome: R-HSA-1358803 Downregulation of ERBB2:ERBB3 signaling 5 KYB29359.1;EFA02110.1;KYB29360.1;EFA02105.1;EFA00158.1 Reactome: R-HSA-5663220 RHO GTPases Activate Formins 51 EFA07755.2;KYB27628.1;KYB26625.1;KYB25071.1;EFA06187.1;KYB25072.1;EEZ99331.1;EFA00411.1;EFA13202.2;EFA07500.2;EFA06856.2;KYB26929.1;EFA08385.2;EFA03253.1;EEZ99348.1;KYB25616.1;EEZ99070.2;EEZ97419.2;EFA11447.2;EFA06492.1;EFA09822.2;KYB26087.1;EFA07677.2;KYB26383.1;KYB27370.1;EEZ97487.2;EFA04506.2;EFA07823.1;KYB25235.1;EFA09410.1;EEZ97891.1;EFA04692.2;EFA07920.2;EEZ99037.2;EFA06663.1;KYB25744.1;KYB26086.1;KYB26085.1;KYB26642.1;EEZ97229.1;KYB29624.1;EFA09537.1;KYB25236.1;EFA00171.1;KYB27439.1;EFA11292.1;KYB25237.1;EFA04833.1;EFA09995.1;EFA05992.2;KYB26892.1 Reactome: R-HSA-5099900 WNT5A-dependent internalization of FZD4 3 EFA02270.2;EFA11263.1;EFA09781.1 Reactome: R-HSA-438066 Unblocking of NMDA receptors, glutamate binding and activation 4 KYB29108.1;KYB28360.1;EFA09715.1;EEZ99807.2 MetaCyc: PWY-6938 NADH repair 2 EFA06064.2;KYB29015.1 MetaCyc: PWY-7286 7-(3-amino-3-carboxypropyl)-wyosine biosynthesis 3 EFA12884.2;EFA10600.1;EFA10439.1 MetaCyc: PWY-6946 Cholesterol degradation to androstenedione II (cholesterol dehydrogenase) 3 EFA08151.1;EFA05073.1;EFA04382.1 Reactome: R-HSA-8939256 RUNX1 regulates transcription of genes involved in WNT signaling 2 KYB27618.1;EFA03630.2 MetaCyc: PWY-7767 L-leucine degradation IV (Stickland reaction) 1 EEZ98004.1 Reactome: R-HSA-70350 Fructose catabolism 2 EFA08779.1;EFA02735.1 MetaCyc: PWY-4302 Aerobic respiration III (alternative oxidase pathway) 4 EFA04683.1;EFA09226.1;EFA02829.1;EFA10709.2 Reactome: R-HSA-176408 Regulation of APC/C activators between G1/S and early anaphase 12 EEZ98737.1;EEZ98849.2;KYB25814.1;EFA01569.1;EEZ97989.1;EEZ99272.2;KYB27271.1;EEZ97189.1;KYB27187.1;EFA01854.1;EFA04231.1;EFA00073.1 MetaCyc: PWY-8001 Felinine and 3-methyl-3-sulfanylbutan-1-ol biosynthesis 4 KYB26172.1;EFA08621.1;KYB26171.1;EFA08906.2 Reactome: R-HSA-380320 Recruitment of NuMA to mitotic centrosomes 35 EFA07920.2;EEZ97891.1;EFA07171.1;KYB29312.1;EFA04833.1;EFA11292.1;EFA03783.1;KYB25597.1;EFA02278.2;EFA12394.2;EEZ97229.1;KYB28460.1;KYB25744.1;EFA06296.1;EFA05270.1;EFA06663.1;EFA04217.1;EEZ97959.1;EEZ99331.1;EEZ98528.1;EFA06187.1;KYB27666.1;KYB26625.1;KYB26030.1;EFA09822.2;EFA06332.2;EFA02136.2;KYB26566.1;EFA10255.2;KYB28459.1;EEZ99070.2;EFA05098.1;EEZ99348.1;EFA09381.2;KYB26929.1 KEGG: 00230+4.1.1.97 Purine metabolism 1 EFA02262.1 Reactome: R-HSA-5637810 Constitutive Signaling by EGFRvIII 1 EFA03198.1 MetaCyc: PWY-5366 Palmitoleate biosynthesis II (plants and bacteria) 7 EFA05203.2;EFA05204.2;EFA05249.2;EFA05201.1;EEZ97866.2;EFA11365.1;EFA05248.1 Reactome: R-HSA-6798163 Choline catabolism 24 KYB26873.1;EFA05530.2;KYB28432.1;EFA05513.1;KYB27092.1;EFA05528.1;EEZ99831.1;EFA08273.1;KYB25985.1;EFA02628.2;EEZ99834.1;EFA01987.2;EFA05536.1;EFA07378.1;KYB28064.1;EFA08835.1;EFA08274.1;EFA05531.1;KYB26872.1;EFA05525.2;EFA03070.1;EFA05534.2;KYB26474.1;EFA05532.1 Reactome: R-HSA-5602680 MyD88 deficiency (TLR5) 1 EFA01304.1 Reactome: R-HSA-75893 TNF signaling 2 EEZ98535.2;KYB29228.1 KEGG: 00230+1.17.1.4 Purine metabolism 1 EFA09973.1 KEGG: 00510+2.4.1.83 N-Glycan biosynthesis 1 EFA06224.2 Reactome: R-HSA-419037 NCAM1 interactions 4 KYB27418.1;KYB27419.1;EFA04092.2;KYB27188.1 Reactome: R-HSA-8866427 VLDLR internalisation and degradation 3 EFA11263.1;EFA06019.1;EFA09781.1 KEGG: 00270+4.1.1.50 Cysteine and methionine metabolism 1 EFA07994.1 MetaCyc: PWY-8004 Entner-Doudoroff pathway I 18 EEZ98809.1;EFA08842.1;KYB24934.1;EFA11310.1;EEZ99016.2;EFA07763.1;KYB27681.1;KYB24935.1;EFA03565.2;EFA05374.1;EFA08517.1;EFA08832.2;EFA10506.1;EFA09609.1;EEZ97193.2;EFA09610.1;KYB25941.1;EFA08071.1 Reactome: R-HSA-164378 PKA activation in glucagon signalling 18 EFA01439.2;EFA10712.2;KYB25553.1;KYB28779.1;EFA03954.2;EFA03628.1;KYB27523.1;KYB28863.1;KYB25554.1;KYB26602.1;KYB25555.1;KYB25552.1;EFA06381.2;EEZ99469.1;KYB25556.1;KYB27619.1;EFA03629.2;EFA03625.2 Reactome: R-HSA-75109 Triglyceride biosynthesis 6 KYB26367.1;EEZ99630.1;EFA04221.1;EFA00308.1;EEZ99510.1;EFA07054.2 MetaCyc: PWY-7836 Ganglio-series glycosphingolipids biosynthesis 1 EFA12048.1 Reactome: R-HSA-392154 Nitric oxide stimulates guanylate cyclase 7 EFA10400.2;EFA01870.2;KYB27920.1;KYB25321.1;EFA02348.1;EEZ98124.2;EFA02701.2 MetaCyc: PWY-7533 Gliotoxin biosynthesis 15 KYB26006.1;EFA00963.1;KYB26008.1;EEZ99479.1;EEZ99709.1;EEZ99578.1;KYB26007.1;EEZ99710.2;KYB28312.1;EFA08560.1;EEZ99480.1;KYB27246.1;KYB27245.1;EFA08612.1;EFA00437.1 Reactome: R-HSA-73780 RNA Polymerase III Chain Elongation 14 EFA01191.1;EFA02494.1;EFA05896.1;EFA07655.1;EFA09807.1;EEZ99545.1;EFA07935.1;EFA03150.1;EFA07031.1;EFA07284.1;KYB26001.1;KYB26491.1;KYB28470.1;EFA11622.1 KEGG: 00230+2.4.2.1 Purine metabolism 2 EFA03250.2;EFA01001.1 Reactome: R-HSA-5576892 Phase 0 - rapid depolarisation 23 EFA11006.2;EFA05958.2;EFA12820.2;EFA11577.2;KYB29720.1;EFA02558.2;KYB29592.1;KYB27055.1;EEZ99807.2;KYB29565.1;KYB29717.1;KYB29593.1;KYB29719.1;EEZ97400.2;KYB29718.1;KYB25145.1;KYB25144.1;KYB27418.1;KYB28360.1;KYB29721.1;KYB27419.1;KYB29722.1;EFA11116.2 Reactome: R-HSA-174403 Glutathione synthesis and recycling 7 EFA04528.1;EFA06615.2;EFA06614.2;EFA06494.1;EFA10955.1;EFA06495.2;EFA11426.1 Reactome: R-HSA-174437 Removal of the Flap Intermediate from the C-strand 11 EFA07958.1;EFA06042.1;EFA09711.2;KYB25721.1;EEZ99558.2;KYB28925.1;EFA09906.2;EFA12891.1;EFA06383.1;KYB27483.1;KYB28926.1 MetaCyc: PWY-5022 4-aminobutanoate degradation V 2 KYB25522.1;KYB25521.1 MetaCyc: PWY-1361 Benzoyl-coa degradation I (aerobic) 3 EFA04382.1;EFA08151.1;EFA05073.1 Reactome: R-HSA-9665246 Resistance of ERBB2 KD mutants to neratinib 1 EFA03198.1 KEGG: 00260+2.1.2.10 Glycine, serine and threonine metabolism 4 EFA02777.2;EFA01139.2;EFA10911.2;EFA05357.1 MetaCyc: PWY-7724 Icosapentaenoate biosynthesis III (8-desaturase, mammals) 21 KYB29211.1;EFA00084.1;EFA05977.1;KYB25453.1;EFA03551.1;EFA09483.1;EFA03752.1;EFA00083.2;KYB25229.1;EFA09796.1;KYB25454.1;EFA05473.2;EFA10643.2;EFA05143.1;EFA10642.1;EFA10641.2;EEZ97311.1;KYB29213.1;EFA09795.1;KYB25455.1;EFA05474.1 Reactome: R-HSA-8964572 Lipid particle organization 1 EFA00283.1 KEGG: 05235+3.1.3.16 PD-L1 expression and PD-1 checkpoint pathway in cancer 39 KYB25189.1;KYB28677.1;EFA06120.1;EFA13210.1;EFA03107.1;EFA10810.2;EFA11234.1;KYB25187.1;KYB28676.1;KYB28792.1;KYB27031.1;EFA00642.2;EFA01582.2;EFA04890.1;EFA07148.1;KYB27758.1;EFA09896.1;KYB26880.1;EFA04151.1;KYB27757.1;KYB25190.1;EEZ97359.1;EFA08945.1;EFA07329.1;EFA07805.1;KYB28159.1;EFA04777.2;EFA00145.2;EFA05539.2;KYB28443.1;EFA10433.2;EEZ99522.2;KYB28233.1;EFA10861.1;EFA02685.2;EFA05189.1;KYB25565.1;EFA03763.1;EFA02473.2 KEGG: 00230+3.5.4.4 Purine metabolism 2 EFA00425.1;EFA00339.1 MetaCyc: PWY-4841 UDP-alpha-D-glucuronate biosynthesis (from myo-inositol) 1 EFA05415.1 Reactome: R-HSA-6809371 Formation of the cornified envelope 20 KYB28092.1;EFA01613.1;EFA10583.2;EFA10582.1;EFA02315.1;EFA01688.2;EFA01620.1;EFA01373.2;EFA10585.2;KYB24612.1;KYB27895.1;KYB28090.1;EFA01617.1;KYB25638.1;EFA10581.1;EFA01616.1;KYB28546.1;KYB25440.1;KYB28089.1;KYB28091.1 Reactome: R-HSA-69541 Stabilization of p53 4 EFA11787.2;KYB29360.1;EFA02110.1;KYB29359.1 KEGG: 00290+4.3.1.19 Valine, leucine and isoleucine biosynthesis 1 EFA05892.1 MetaCyc: PWY-6363 D-myo-inositol (1,4,5)-trisphosphate degradation 2 EFA12936.1;KYB25020.1 MetaCyc: PWY-6277 Superpathway of 5-aminoimidazole ribonucleotide biosynthesis 5 EFA02192.2;EFA11870.2;EEZ97659.2;KYB25818.1;EEZ98112.1 MetaCyc: PWY-6583 Pyruvate fermentation to butanol I 3 EFA05073.1;EFA08151.1;EFA04382.1 Reactome: R-HSA-2173796 SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription 5 KYB29359.1;EFA02110.1;EEZ99094.1;KYB29360.1;EFA02211.1 Reactome: R-HSA-6782315 tRNA modification in the nucleus and cytosol 27 EFA00476.1;EFA09438.2;EEZ98974.2;EFA11366.1;KYB25335.1;EEZ98379.2;EEZ99485.2;EFA04205.1;KYB28647.1;EFA09124.2;KYB25336.1;KYB26719.1;EFA11905.1;EFA10424.2;EFA02961.2;EFA09658.1;EFA01122.1;EFA05938.1;KYB26720.1;EFA06561.1;EFA02043.1;EFA04885.1;EFA02997.1;EEZ97178.2;EFA02689.1;EFA08846.1;EFA00359.1 KEGG: 00380+1.14.13.9 Tryptophan metabolism 1 EEZ98408.1 Reactome: R-HSA-199418 Negative regulation of the PI3K/AKT network 1 EFA02105.1 Reactome: R-HSA-71403 Citric acid cycle (TCA cycle) 26 EFA11202.1;EFA08121.1;EFA09226.1;EFA05014.1;EFA03279.1;EFA03750.1;EFA04017.1;EFA03144.1;EEZ99263.1;EFA03278.1;EFA04299.1;EFA07230.2;EEZ99075.1;EFA10595.2;EFA07507.1;EFA04683.1;EFA11129.1;EFA04972.1;EEZ99264.1;EFA07160.1;EFA10709.2;EEZ99082.2;EFA09539.1;EFA10361.1;EFA02829.1;KYB27324.1 KEGG: 00350+2.6.1.1 Tyrosine metabolism 3 KYB27212.1;EFA04122.1;EFA03109.1 MetaCyc: PWY-7053 Docosahexaenoate biosynthesis I (lower eukaryotes) 2 EFA03551.1;EFA05143.1 MetaCyc: PWY-5695 Inosine 5'-phosphate degradation 5 EFA09973.1;EFA11857.1;EFA03250.2;EFA01001.1;EFA01792.1 Reactome: R-HSA-450604 KSRP (KHSRP) binds and destabilizes mRNA 12 EEZ99918.1;EFA07181.2;EFA07836.1;EEZ98806.1;EFA01958.1;EFA07855.1;EFA02571.1;EFA06447.1;EFA06999.1;EEZ97803.1;EFA05246.1;EFA06035.2 MetaCyc: PWY-6722 Candicidin biosynthesis 3 EFA05436.2;EFA03586.1;EFA07129.2 Reactome: R-HSA-5607763 CLEC7A (Dectin-1) induces NFAT activation 2 KYB29732.1;EFA11212.2 Reactome: R-HSA-8854518 AURKA Activation by TPX2 16 EFA02136.2;EFA06332.2;EFA03783.1;KYB25597.1;KYB26566.1;KYB28459.1;EFA05098.1;EFA10255.2;EFA09381.2;KYB28460.1;KYB25744.1;EEZ97959.1;EFA00031.1;EFA07920.2;KYB27666.1;EEZ98528.1 KEGG: 04070+2.7.1.137 Phosphatidylinositol signaling system 1 EEZ98191.1 Reactome: R-HSA-2672351 Stimuli-sensing channels 60 EEZ98785.2;EFA12114.2;EFA05242.1;KYB27211.1;EFA08874.1;KYB26140.1;EFA04691.1;EFA02215.1;KYB28387.1;EEZ97433.1;KYB26420.1;EFA00320.2;EFA04121.2;KYB29508.1;EFA11834.2;KYB29509.1;EEZ98137.2;EFA10172.2;KYB27860.1;KYB25719.1;KYB26357.1;KYB29360.1;EFA05509.2;KYB25129.1;EFA00686.2;KYB25718.1;EFA05375.2;EFA07756.1;KYB27034.1;EFA08980.2;EFA07906.1;EFA02110.1;KYB28301.1;KYB28006.1;EFA02214.1;KYB28433.1;EFA01725.2;KYB26862.1;KYB29485.1;EFA11788.2;EFA04922.2;EFA07961.1;KYB26842.1;KYB29359.1;KYB28426.1;EEZ97395.2;EFA02216.1;KYB27522.1;EFA04526.1;EFA05355.2;KYB29507.1;EFA08873.2;EFA08448.1;EEZ99829.2;KYB27274.1;EEZ97621.1;EFA05967.2;KYB27012.1;EFA05007.2;EEZ98825.2 Reactome: R-HSA-3656532 TGFBR1 KD Mutants in Cancer 3 EEZ97734.1;EFA07576.2;EFA05099.1 MetaCyc: PWY-5839 Menaquinol-7 biosynthesis 2 EFA05173.2;KYB27131.1 MetaCyc: PWY-5083 NAD/NADH phosphorylation and dephosphorylation 2 KYB26619.1;EFA08909.2 Reactome: R-HSA-179409 APC-Cdc20 mediated degradation of Nek2A 15 EFA01569.1;EEZ97989.1;KYB25814.1;KYB27187.1;EFA01854.1;EFA04231.1;EFA00073.1;EEZ99272.2;KYB29359.1;EFA02110.1;KYB27271.1;EEZ97189.1;EEZ98737.1;EEZ98849.2;KYB29360.1 Reactome: R-HSA-8849473 PTK6 Expression 1 EFA01004.2 Reactome: R-HSA-2206282 MPS IIIB - Sanfilippo syndrome B 2 EFA02249.1;KYB27868.1 MetaCyc: PWY-5739 GDP-D-perosamine biosynthesis 1 EFA01082.1 MetaCyc: PWY-5723 Rubisco shunt 13 EFA01628.1;EFA08842.1;EEZ97576.1;EEZ98187.1;EFA09610.1;KYB25941.1;EEZ97193.2;KYB24935.1;EEZ99016.2;KYB24934.1;EFA09609.1;EFA10506.1;EFA08832.2 Reactome: R-HSA-442720 CREB1 phosphorylation through the activation of Adenylate Cyclase 4 KYB28779.1;EEZ99469.1;KYB26602.1;EFA06381.2 Reactome: R-HSA-3000484 Scavenging by Class F Receptors 6 KYB29704.1;EFA11425.1;KYB26997.1;KYB29706.1;EFA11302.1;KYB29705.1 Reactome: R-HSA-9037629 Lewis blood group biosynthesis 5 EFA05857.2;EFA01784.2;EFA08198.2;EFA04106.1;EFA05856.1 Reactome: R-HSA-5675221 Negative regulation of MAPK pathway 11 EFA05992.2;KYB26383.1;EFA05346.2;EFA10433.2;KYB29360.1;EFA11234.1;EFA06120.1;KYB26642.1;EFA10708.1;EFA02110.1;KYB29359.1 KEGG: 00960+2.6.1.5 Tropane, piperidine and pyridine alkaloid biosynthesis 1 EFA03251.1 MetaCyc: PWY-7942 5-oxo-L-proline metabolism 5 EFA11426.1;KYB25675.1;EFA10955.1;KYB25674.1;EFA06046.2 Reactome: R-HSA-425381 Bicarbonate transporters 5 KYB27585.1;KYB28887.1;KYB27584.1;KYB27586.1;KYB27587.1 Reactome: R-HSA-8949215 Mitochondrial calcium ion transport 3 EFA08733.2;EFA09907.1;EFA03728.2 Reactome: R-HSA-2151201 Transcriptional activation of mitochondrial biogenesis 26 KYB26838.1;EFA05714.1;KYB29566.1;EFA08558.1;KYB26875.1;EFA06486.2;KYB27349.1;EFA08214.1;KYB27348.1;EFA00806.2;EFA11369.2;EFA09191.1;KYB25039.1;KYB28596.1;KYB25037.1;KYB26900.1;EFA02176.1;EFA10996.1;EEZ99054.2;EFA01361.1;KYB28595.1;KYB29567.1;EFA00172.2;EFA11222.2;EFA12821.2;EFA08534.1 KEGG: 00195+7.1.2.2 Photosynthesis 4 EFA07428.1;EFA05714.1;EFA02908.1;EFA10717.1 Reactome: R-HSA-5693571 Nonhomologous End-Joining (NHEJ) 14 EEZ99162.2;EFA07487.1;EEZ98007.1;EFA10575.1;EFA13677.2;KYB26425.1;EFA03479.1;EFA11787.2;EFA07537.1;EEZ97760.2;KYB24563.1;EFA04568.2;KYB24996.1;EFA05681.1 Reactome: R-HSA-2206296 MPS II - Hunter syndrome 1 EFA00827.1 Reactome: R-HSA-8941326 RUNX2 regulates bone development 2 EFA03630.2;KYB27618.1 MetaCyc: PWY-7234 Inosine-5'-phosphate biosynthesis III 3 EFA08776.1;EEZ98830.1;EEZ97680.1 MetaCyc: PWY-5331 Taurine biosynthesis I 1 EFA06970.1 MetaCyc: PWY-7442 Drosopterin and aurodrosopterin biosynthesis 3 EFA06106.1;EFA13034.1;EFA05403.1 Reactome: R-HSA-170670 Adenylate cyclase inhibitory pathway 14 KYB27523.1;KYB27619.1;KYB25556.1;EFA03628.1;EFA03954.2;KYB25554.1;KYB28863.1;EFA03625.2;EFA03629.2;KYB25552.1;KYB25555.1;EFA10712.2;EFA01439.2;KYB25553.1 MetaCyc: PWY-6333 Acetaldehyde biosynthesis I 1 EEZ98950.2 Reactome: R-HSA-5617833 Cilium Assembly 14 KYB26929.1;EFA06663.1;EEZ99348.1;KYB26625.1;EFA06187.1;EEZ97229.1;EEZ99070.2;EEZ99331.1;EFA00356.2;EEZ97891.1;EFA11292.1;KYB28942.1;EFA04833.1;EFA09822.2 MetaCyc: PWY-7111 Pyruvate fermentation to isobutanol (engineered) 1 EEZ98950.2 Reactome: R-HSA-196807 Nicotinate metabolism 8 KYB29062.1;EFA08909.2;KYB25712.1;EFA10127.2;EFA01802.1;KYB26619.1;EEZ98343.1;EFA06359.1 MetaCyc: PWY-6944 Androstenedione degradation 3 EFA08151.1;EFA05073.1;EFA04382.1 MetaCyc: PWY-7791 UMP biosynthesis III 2 EFA10197.1;EFA01834.2 MetaCyc: PWY-8072 Alanine racemization 1 EFA09643.1 Reactome: R-HSA-3878781 Glycogen storage disease type IV (GBE1) 1 EFA11030.1 KEGG: 00270+4.2.1.109 Cysteine and methionine metabolism 1 EFA07698.1 Reactome: R-HSA-175474 Assembly Of The HIV Virion 3 KYB29359.1;EFA02110.1;KYB29360.1 Reactome: R-HSA-5083633 Defective POMT1 causes MDDGA1, MDDGB1 and MDDGC1 4 KYB26306.1;EFA03006.2;KYB26307.1;EFA06291.1 Reactome: R-HSA-204174 Regulation of pyruvate dehydrogenase (PDH) complex 4 EFA00132.1;EFA06557.2;EFA00070.1;EFA06896.1 Reactome: R-HSA-68867 Assembly of the pre-replicative complex 19 EFA06929.1;EFA03095.1;EEZ97575.1;EFA00549.1;KYB29174.1;EFA12381.1;EFA05162.2;EFA10460.1;EEZ97925.1;EFA03157.1;EFA06648.2;EFA03620.1;KYB26668.1;EFA06449.1;EEZ97375.1;EFA06047.1;EFA13575.1;EFA11188.2;EFA06374.2 MetaCyc: PWY-7077 N-acetyl-D-galactosamine degradation 1 KYB27794.1 Reactome: R-HSA-434316 Fatty Acids bound to GPR40 (FFAR1) regulate insulin secretion 3 KYB29172.1;EEZ98203.2;KYB27786.1 Reactome: R-HSA-416572 Sema4D induced cell migration and growth-cone collapse 2 KYB27402.1;EFA04406.2 Reactome: R-HSA-72695 Formation of the ternary complex, and subsequently, the 43S complex 48 EFA07141.1;EEZ99099.1;EEZ97224.1;EFA05170.2;EFA07164.1;EFA06534.1;EFA13692.2;EFA04453.1;KYB29359.1;EEZ98852.1;EFA08069.1;EFA07317.1;EEZ99635.1;EFA06341.1;EFA09390.1;EFA04093.1;EFA02554.1;EFA10249.1;EFA01611.1;EEZ99942.1;EEZ97645.1;EFA09067.1;EFA08366.2;EEZ98728.1;EFA05373.1;EFA06382.1;EEZ97313.1;EFA10201.2;EEZ99023.1;EFA00935.2;EFA09970.1;EFA06707.1;EFA04159.1;KYB27801.1;KYB26424.1;EFA11293.1;EFA05867.1;EFA01765.1;KYB29360.1;KYB25876.1;EFA10123.1;EFA00209.1;EFA11360.1;EFA08849.1;EFA00505.1;EEZ98503.1;EFA02515.1;EFA03441.1 Reactome: R-HSA-1234176 Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha 41 EFA02110.1;KYB29360.1;KYB27557.1;EFA13218.1;EFA02345.1;EFA08911.2;EEZ99493.1;EFA07468.1;EEZ97876.1;KYB27556.1;EFA03341.1;KYB26764.1;EFA06519.1;EFA11079.1;EFA06741.1;EFA06200.1;EFA08664.1;EFA07261.2;EEZ97564.1;EFA05865.1;EFA04054.1;EFA08798.1;EFA09524.2;EFA08601.1;EFA09518.2;EFA07659.2;EFA05871.2;EEZ98185.1;EFA02331.1;EFA05105.1;EFA03019.1;KYB26545.1;KYB29359.1;EFA05912.1;EFA07110.1;KYB24713.1;EEZ99004.1;EFA05833.1;KYB25309.1;EFA04284.1;EFA05370.2 KEGG: 00230+2.4.2.7 Purine metabolism 1 EFA06669.1 Reactome: R-HSA-4793952 Defective MGAT2 causes MGAT2-CDG (CDG-2a) 1 EFA12804.1 KEGG: 00983+2.7.4.6 Drug metabolism - other enzymes 5 EFA03917.1;EEZ98594.1;EFA07171.1;EEZ99726.1;KYB26165.1 MetaCyc: PWY-5079 L-phenylalanine degradation III 1 EEZ98950.2 Reactome: R-HSA-9636467 Blockage of phagosome acidification 1 EFA08618.1 Reactome: R-HSA-69091 Polymerase switching 17 EFA06042.1;EFA04623.2;EFA07958.1;EFA12420.2;KYB28925.1;EFA03020.2;EFA07996.1;EFA02756.1;EFA03814.1;EFA07750.2;EFA09576.1;KYB25721.1;KYB25740.1;EFA08812.2;KYB28926.1;EFA10435.1;EFA08916.1 KEGG: 00900+5.3.3.2 Terpenoid backbone biosynthesis 1 EFA07280.1 Reactome: R-HSA-5627123 RHO GTPases activate PAKs 2 EFA13430.2;EFA03253.1 Reactome: R-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal 31 KYB27370.1;EFA07755.2;EFA04506.2;EEZ97487.2;KYB25071.1;KYB25072.1;KYB25235.1;EFA09410.1;EFA07823.1;EFA07920.2;EFA04692.2;EFA07500.2;EFA06856.2;EFA13202.2;KYB25744.1;KYB25616.1;KYB29624.1;KYB26642.1;EFA00171.1;KYB25236.1;EFA09537.1;EFA11447.2;KYB27439.1;EEZ97419.2;KYB25237.1;EFA06492.1;EFA09995.1;KYB26892.1;EFA07677.2;KYB26383.1;EFA05992.2 Reactome: R-HSA-1222556 ROS and RNS production in phagocytes 25 KYB29412.1;EFA02241.1;KYB28989.1;EFA03371.1;EFA06225.1;EFA02476.1;EFA01142.2;KYB25321.1;EFA08618.1;KYB29411.1;EFA11012.1;EEZ99208.1;KYB29409.1;EFA02908.1;EEZ98813.2;KYB29413.1;EEZ97227.1;EFA06700.2;EFA02242.2;EFA10717.1;EFA10400.2;EEZ99071.2;EFA05894.1;KYB29410.1;EEZ98406.2 Reactome: R-HSA-166208 mTORC1-mediated signalling 10 EFA08847.1;EEZ98728.1;EFA11293.1;EEZ97603.1;EFA12722.1;EFA07964.1;EEZ99978.2;EFA02668.2;EFA03068.1;EFA09095.1 KEGG: 00230+6.3.5.2 Purine metabolism 1 EFA09313.1 KEGG: 00970+6.1.1.18 Aminoacyl-tRNA biosynthesis 1 EEZ99471.1 Reactome: R-HSA-162658 Golgi Cisternae Pericentriolar Stack Reorganization 4 EFA10708.1;KYB27319.1;EFA06519.1;EFA08682.1 MetaCyc: PWY-6121 5-aminoimidazole ribonucleotide biosynthesis I 5 EEZ97659.2;EEZ98112.1;KYB25818.1;EFA02192.2;EFA11870.2 MetaCyc: PWY-7199 Pyrimidine deoxyribonucleosides salvage 3 EFA08865.1;EFA02095.1;EFA11748.1 MetaCyc: PWY-7798 Protein S-nitrosylation and denitrosylation 1 EEZ98950.2 KEGG: 00561+3.1.3.4 Glycerolipid metabolism 2 EFA07054.2;KYB26367.1 KEGG: 00740+3.6.1.9 Riboflavin metabolism 2 EFA04414.1;EFA03919.1 KEGG: 00900+2.5.1.58 Terpenoid backbone biosynthesis 1 EFA07131.1 MetaCyc: PWY-7849 Urate conversion to allantoin III 3 EFA02262.1;EEZ99723.1;KYB28295.1 KEGG: 00970+6.1.1.6 Aminoacyl-tRNA biosynthesis 1 EFA04272.1 KEGG: 00030+3.1.3.11 Pentose phosphate pathway 2 EEZ98675.1;KYB27612.1 Reactome: R-HSA-68884 Mitotic Telophase/Cytokinesis 1 EFA04570.1 Reactome: R-HSA-674695 RNA Polymerase II Pre-transcription Events 50 EFA12997.1;KYB29064.1;EEZ99586.2;EFA10288.1;KYB28470.1;EFA00018.1;EFA00606.1;EFA00603.1;EFA07031.1;EEZ97398.2;EFA00397.1;EFA00911.1;EFA07995.2;EFA05226.1;EFA02321.1;EFA05523.2;KYB25378.1;KYB25152.1;EFA03550.1;EFA03150.1;EFA11878.1;KYB26001.1;EFA10605.2;EEZ98143.1;EEZ98144.2;EFA07302.1;EFA03559.1;EFA02310.1;EFA07055.2;EFA04061.1;EEZ97886.2;EFA06469.1;EEZ99738.1;EFA03759.1;EFA05897.1;KYB29038.1;EFA06253.1;EFA00328.1;EFA03052.1;EFA07148.1;KYB25207.1;EFA03093.1;EFA05896.1;EFA05446.1;EEZ97432.2;EFA05606.1;KYB29037.1;EEZ97363.1;EFA08590.1;EFA06560.1 KEGG: 00250+2.4.2.14 Alanine, aspartate and glutamate metabolism 2 EEZ97659.2;EEZ98112.1 Reactome: R-HSA-71032 Propionyl-CoA catabolism 1 EFA03463.2 MetaCyc: PWY-6351 D-myo-inositol (1,4,5)-trisphosphate biosynthesis 8 KXZ75917.1;KYB27925.1;EFA05079.1;KYB28995.1;KYB28994.1;KYB27786.1;EFA12319.2;KXZ75916.1 KEGG: 00564+4.1.1.65 Glycerophospholipid metabolism 1 KYB29477.1 MetaCyc: PWY-7094 Fatty acid salvage 3 EFA04382.1;EFA05073.1;EFA08151.1 Reactome: R-HSA-1433557 Signaling by SCF-KIT 4 KYB24939.1;KYB24940.1;KYB24938.1;KYB29656.1 Reactome: R-HSA-3371511 HSF1 activation 5 EFA09711.2;EFA09906.2;EFA12891.1;EFA07465.1;KYB27483.1 MetaCyc: PWY-5963 Thio-molybdenum cofactor biosynthesis 1 EEZ98196.1 Reactome: R-HSA-6803157 Antimicrobial peptides 8 EFA05744.1;KYB28764.1;EFA01280.1;EFA12467.1;EFA01375.1;EFA11602.1;EFA01262.1;EFA01279.2 Reactome: R-HSA-2514853 Condensation of Prometaphase Chromosomes 9 EFA06967.1;EFA02258.2;EFA01238.1;EFA09978.2;KYB29684.1;EFA10063.2;EFA02834.2;EEZ97852.2;EFA00571.1 KEGG: 00250+3.5.1.2 Alanine, aspartate and glutamate metabolism 1 EFA11037.2 Reactome: R-HSA-918233 TRAF3-dependent IRF activation pathway 3 EFA07517.1;EFA06854.1;EFA02517.2 Reactome: R-HSA-196843 Vitamin B2 (riboflavin) metabolism 2 EFA06175.2;EEZ99554.1 Reactome: R-HSA-168271 Transport of Ribonucleoproteins into the Host Nucleus 19 EFA01249.2;EFA01782.2;KYB28401.1;EFA03859.1;KYB29271.1;EFA07823.1;KYB29364.1;EFA04928.2;KYB28630.1;EEZ98695.2;EFA05993.1;EFA00605.1;EFA11141.2;EFA09537.1;KYB29624.1;EFA11447.2;EEZ97868.2;EFA03584.1;EFA00581.2 Reactome: R-HSA-427652 Sodium-coupled phosphate cotransporters 1 KYB27717.1 KEGG: 00562+5.3.1.1 Inositol phosphate metabolism 1 EFA01748.1 MetaCyc: PWY-7437 Protein O-[N-acetyl]-glucosylation 4 EFA01003.1;KYB28293.1;KYB25389.1;KYB25388.1 Reactome: R-HSA-2160916 Hyaluronan uptake and degradation 12 EEZ98597.1;EFA05960.2;KYB26528.1;EFA07841.1;EFA06863.2;EFA07069.1;EFA05959.1;EFA11380.2;KYB26527.1;EFA07843.2;EFA07842.1;EFA06836.2 MetaCyc: PWY-5537 Pyruvate fermentation to acetate V 5 EFA11129.1;EFA11202.1;EFA03750.1;EFA05014.1;EFA07160.1 MetaCyc: PWY-6549 L-glutamine biosynthesis III 5 EFA10595.2;EEZ97848.1;EFA04299.1;EFA09539.1;EEZ99821.1 MetaCyc: PWY-7799 Arg/N-end rule pathway (eukaryotic) 6 KYB26774.1;EFA06576.1;EFA00780.2;EFA08318.1;EFA13129.1;EEZ97675.1 MetaCyc: PWY-7411 Phosphatidate biosynthesis (yeast) 11 EEZ97257.1;EFA09975.1;KYB27110.1;EFA02132.1;EEZ97656.1;KYB29133.1;KYB29132.1;EEZ98249.2;KYB27111.1;EFA06119.2;EFA04525.1 KEGG: 00380+1.11.1.6 Tryptophan metabolism 3 KYB28799.1;EEZ97708.2;EEZ97738.1 Reactome: R-HSA-8948700 Competing endogenous RNAs (ceRNAs) regulate PTEN translation 7 EFA11590.1;EFA09197.2;KYB25778.1;KYB26000.1;EFA08972.2;EFA04626.2;KYB25999.1 Reactome: R-HSA-420029 Tight junction interactions 2 KYB27803.1;KYB27802.1 MetaCyc: PWY-5367 Petroselinate biosynthesis 7 EFA05248.1;EEZ97866.2;EFA11365.1;EFA05204.2;EFA05201.1;EFA05249.2;EFA05203.2 Reactome: R-HSA-9657050 Defective OGG1 Localization 1 EFA06198.1 Reactome: R-HSA-373760 L1CAM interactions 1 EFA00894.1 Reactome: R-HSA-2559580 Oxidative Stress Induced Senescence 11 KYB25778.1;EFA02110.1;KYB29359.1;EFA10708.1;EFA10731.1;EFA09273.1;KYB24563.1;KYB29360.1;EFA00645.1;EFA08972.2;EFA11394.1 KEGG: 00620+4.1.1.32 Pyruvate metabolism 2 KYB26254.1;EFA06223.2