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Ceratitis capitata

Resource Type
Common Name
Mediterranean fruit fly

The medfly has been an established lab organism for several decades, and is notable as being the closest non-drosophilid relative to Drosophila subject to genetic analysis, with broad chromosomal syntenic relationships established. It is also one of the most important agricultural pests worldwide due to its broad plant host range throughout tropical and sub-tropical regions.

Genetic studies have been driven by efforts to use genetic manipulation to improve the sterile insect technique which is used to control medfly and several other tephritid species through multi-tactical integrated pest management approaches. It was among the first non-drosophilid insects to have a polytene chromosomal genetic map created, having ~30 cloned genes mapped by in situ hybridization. It was also the first to have its germ-line efficiently transformed by a transposon-based vector system. It is now a model system for genetic manipulation in non-drosophilids, including functional genomics analysis, new vector systems for transgene stabilization, genomic targeting, and transgenic strains created for population control.

Data were generated as part of the Baylor College of Medicine's i5k pilot project.

Please cite the following publication when using this dataset:
Papanicolaou, Alexie, et al. "The whole genome sequence of the Mediterranean fruit fly, Ceratitis capitata (Wiedemann), reveals insights into the biology and adaptive evolution of a highly invasive pest species." Genome Biology 17.1 (2016): 192.


  1. Thomas GWC, Dohmen E, Hughes DST, Murali SC, Poelchau M, Glastad K, Anstead CA, Ayoub NA, Batterham P, Bellair M, Binford GJ, Chao H, Chen YH, Childers C, Dinh H, Doddapaneni HV, Duan JJ, Dugan S, Esposito LA, Friedrich M, Garb J, Gasser RB, Goodisman MAD, Gundersen-Rindal DE, Han Y, Handler AM, Hatakeyama M, Hering L, Hunter WB, Ioannidis P, Jayaseelan JC, Kalra D, Khila A, Korhonen PK, Lee CE, Lee SL, Li Y, Lindsey ARI, Mayer G, McGregor AP, McKenna DD, Misof B, Munidasa M, Munoz-Torres M, Muzny DM, Niehuis O, Osuji-Lacy N, Palli SR, Panfilio KA, Pechmann M, Perry T, Peters RS, Poynton HC, Prpic NM, Qu J, Rotenberg D, Schal C, Schoville SD, Scully ED, Skinner E, Sloan DB, Stouthamer R, Strand MR, Szucsich NU, Wijeratne A, Young ND, Zattara EE, Benoit JB, Zdobnov EM, Pfrender ME, Hackett KJ, Werren JH, Worley KC, Gibbs RA, Chipman AD, Waterhouse RM, Bornberg-Bauer E, Hahn MW, Richards S. Gene content evolution in the arthropods.. Genome biology. 2020 01 23; 21(1):15.
  2. Papanicolaou A, Schetelig MF, Arensburger P, Atkinson PW, Benoit JB, Bourtzis K, Castañera P, Cavanaugh JP, Chao H, Childers C, Curril I, Dinh H, Doddapaneni H, Dolan A, Dugan S, Friedrich M, Gasperi G, Geib S, Georgakilas G, Gibbs RA, Giers SD, Gomulski LM, González-Guzmán M, Guillem-Amat A, Han Y, Hatzigeorgiou AG, Hernández-Crespo P, Hughes DS, Jones JW, Karagkouni D, Koskinioti P, Lee SL, Malacrida AR, Manni M, Mathiopoulos K, Meccariello A, Munoz-Torres , Murali SC, Murphy TD, Muzny DM, Oberhofer G, Ortego F, Paraskevopoulou MD, Poelchau M, Qu J, Reczko M, Robertson HM, Rosendale AJ, Rosselot AE, Saccone G, Salvemini M, Savini G, Schreiner P, Scolari F, Siciliano P, Sim SB, Tsiamis G, Ureña E, Vlachos IS, Werren JH, Wimmer EA, Worley KC, Zacharopoulou A, Richards S, Handler AM. The whole genome sequence of the Mediterranean fruit fly, Ceratitis capitata (Wiedemann), reveals insights into the biology and adaptive evolution of a highly invasive pest species.. Genome biology. 2016 09 22; 17(1):192.
Organism Image
Image Credit
NameProgramDate Constructed
Ceratitis capitata whole genome assembly, NCBI releaseBaylor College of Medicine genome assembly pipeline, followed by NCBI GenBank and RefSeq processingMay 14th, 2012
JAMg Consensus Gene Set v1JAMgJul 1st, 2014
BCM annotation of the Ceratitis capitata assembly using Maker and additional analysesMAKEROct 1st, 2013
Ceratitis capitata Official Gene Set OGSv1reconsile_OGSs_to_masterJun 16th, 2017
Functional annotation of Ceratitis capitata Official Gene Set OGSv1AgBase functional annotation pipelineSep 30th, 2020
Whole genome assembly of Ceratitis capitataBaylor College of Medicine genome assembly pipelineJul 16th, 2013
Assembly Stats
Contig N50
Scaffold N50
GC Content
Other Information
Community Contact
Al Handler|